tbuckley/cabot-search huggingface dataset:
Abstract 19025: Frailty Assessment in Early Invasive Percutaneous Coronary (PCI) Management of Non-ST-Elevation Acute Coronary Syndromes (NSTE-CS): Is Clinical Perception of Frailty Enough?
Authors: Tanvir K Kahlon, Sima Salahie, Karen Hagglund, Nancy Mesiha
Journal: Circulation (2016)

Introduction:  As our population ages, the role of frailty in CAD is increasingly clinically relevant. Approximately 12.4% of the US population with CAD is 65 years and older. It has been noted that females and the elderly are treated less aggressively in the setting of NSTE-CS.   Hypothesis:  Subjective assessment of frailty compared to objective measure of frailty shows a significant difference in PCI management of NSTE-CS in women versus men, in the elderly population.   Methods:  We conducted a retrospective review of patients 65 and older, from March 1, 2015 to December 31, 2015 that were admitted to an urban, multiracial tertiary care center for unstable angina or NSTEMI (n = 120). Primary endpoint of measured frailty compared with subjective assessment of frailty amongst the genders was assessed in the setting of NSTE-CS. Secondary endpoint of outcomes post - early intervention PCI in the frail were also assessed.   Results:  Females presented with a higher GRACE risk score compared with men with a mean of 132 ± 30, p    Conclusions:  Subjective and objective measure of frailty showed no statistically significant difference in our sample population. Gender showed no statistical difference in frailty scores or outcomes post PCI. Objectively high measures of frailty were associated with poorer outcomes overall with or without early PCI.
Abstract 17117: Progression of Vessel Healing and Neoatherosclerosis After Sirolimus-Eluting Stent Implantation: Comparisons of Serial Optical Coherence Tomography Findings Between Mid-and Late-Phase Follow-Up
Authors: Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Junya Shite, Tsuyoshi Osue, Ken-ichi Hirata
Journal: Circulation (2012)

Background ; A recent report has demonstrated a possible link between neointimal atherosclerotic change and late in-stent restenosis after sirolimus-eluting stent (SES) implantation. This study is to clarify the natural history of neoatherosclerosis after SES implantation by serial optical coherence tomography (OCT) evaluation.   Methods ; Sixty-four SES from 47 event-free patients were evaluated by OCT 6 months (mid-phase) and 5 years (late-phase) after implantation. In addition to standard OCT variables, the frequency of atherogenic neointima (AN) was evaluated. Atherogenic neointima was defined as neointima containing a diffuse border and a signal-poor region with invisible struts underneath due to marked signal attenuation.   Results ; The percentage of uncovered and malapposed struts significantly decreased from the mid- to the late-phase follow-up (5.0% to 0.7%, p   Conclusion ; Improved neointimal coverage without excess neointimal proliferation was observed by serial OCT analysis after SES implantation. The frequencies of uncovered and malapposed struts decreased over time, suggesting that continuous vessel healing occurred in the majority of SES 5 years after stenting. Atherogenic neointima was observed mostly at the late-phase follow-up, suggesting that neoatherosclerosis, which is associated with high serum triglyceride levels, progressed over time.
Results of a Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Trifluridine/Tipiracil (TAS-102) Monotherapy in Asian Patients With Previously Treated Metastatic Colorectal Cancer: The TERRA Study
Authors: Jianming Xu, Tae Won Kim, Lin Shen, Virote Sriuranpong, Hongming Pan, Ruihua Xu, Weijian Guo, Sae-Won Han, Tianshu Liu, Young Suk Park, Chunmei Shi, Yuxian Bai, Feng Bi, Joong Bae Ahn, Shukui Qin, Qi Li, Changping Wu, Dong Ma, Donghu Lin, Jin Li
Journal: Journal of Clinical Oncology (2017)

Purpose Trifluridine/tipiracil (TAS-102) was effective in patients with metastatic colorectal cancer (mCRC) in a phase II Japanese trial. This regional trial evaluated the efficacy and safety of trifluridine/tipiracil in Asian patients with mCRC with or without exposure to biologic therapy. Patients and Methods This randomized, double-blind, placebo-controlled, phase III trial was conducted at 30 sites in China, the Republic of Korea, and Thailand. Patients ≥ 18 years old with histologically or cytologically confirmed adenocarcinoma of the colon or rectum and known KRAS status who were refractory or intolerant to two or more prior chemotherapy regimens were enrolled. Eligible patients were randomly assigned (2:1 ratio; minimization method) to receive trifluridine/tipiracil (twice per day orally; 5 days on and 2 days off for 2 weeks, followed by 14 days off per cycle) or placebo. The primary end point was overall survival (intent-to-treat population). Results Between October 16, 2013, and June 15, 2015, 406 patients were randomly assigned to receive trifluridine/tipiracil (n = 271) or placebo (n = 135). Risk of death was significantly lower in the trifluridine/tipiracil arm than in the placebo arm (hazard ratio for death, 0.79; 95% CI, 0.62 to 0.99; log-rank P = .035). Median overall survival was significantly longer in the trifluridine/tipiracil than in the placebo arm (7.8 months [95% CI, 7.1 to 8.8 months] v 7.1 months [95% CI, 5.9 to 8.2 months], respectively), for a median survival follow-up time of 13.8 months (95% CI, 13.1 to 15.3 months) compared with 13.4 months (95% CI, 11.6 to 17.3 months), respectively. The incidence of serious adverse events was similar between the arms (trifluridine/tipiracil, n = 63 [23.2%]; placebo, n = 32 [23.7%]). No treatment-related deaths were reported. Conclusion Trifluridine/tipiracil has a statistically significant survival benefit compared with placebo in Asian patients with mCRC refractory or intolerant to standard chemotherapies, regardless of exposure to biologic therapy. The safety profile is similar to previous reports.
Confocal super-resolution imaging of the glomerular filtration barrier enabled by tissue expansion
Authors: David Unnersjö-Jess, Lena Scott, Sonia Zambrano Sevilla, Jaakko Patrakka, Hans Blom, Hjalmar Brismar
Journal: Kidney International (2017)

The glomerular filtration barrier, has historically only been spatially resolved using electron microscopy due to the nanometer-scale dimensions of these structures. Recently, it was shown that the nanoscale distribution of proteins in the slit diaphragm can be resolved by fluorescence based stimulated emission depletion microscopy, in combination with optical clearing. Fluorescence microscopy has advantages over electron microscopy in terms of multiplex imaging of different epitopes, and also the amount of volumetric data that can be extracted from thicker samples. However, stimulated emission depletion microscopy is still a costly technique commonly not available to most life science researchers. An imaging technique with which the glomerular filtration barrier can be visualized using more standard fluorescence imaging techniques is thus desirable. Recent studies have shown that biological tissue samples can be isotropically expanded, revealing nanoscale localizations of multiple epitopes using confocal microscopy. Here we show that kidney samples can be expanded sufficiently to study the finest elements of the filtration barrier using confocal microscopy. Thus, our result opens up the possibility to study protein distributions and foot process morphology on the effective nanometer-scale.
Abstract 11891: Nitroglycerin Improves Microcirculation During and After Cardiopulmonary Resuscitation in a Porcine Model of Cardiac Arrest
Authors: Changqing Miao, Zhengfei Yang, Cai Wen, Xiaozhu Zhai, Tao Yu, Mary A Peberdy, Joseph P Ornato, Wanchun Tang
Journal: Circulation (2016)

Introduction: We have previously demonstrated that vasopressors administered during cardiopulmonary resuscitation (CPR) significantly decrease microcirculatory flow. In the present study, we investigated the effects of nitroglycerin on the macrocirculation macro and microcirculation and microcirculation during and after CPR in a porcine model of cardiac arrest (CA). Hypothesis: Nitroglycerin improves microcirculation but without undesirable effects on the macrocirculation during and after resuscitation. Methods: Ten male domestic pigs weighing 40±2 kg were utilized. Ventricular fibrillation was electrically induced and untreated for 5 min. The animals were then randomized to receive NTG (N group) or saline (C group). Coincident with the start of CPR, NTG (5 μg/kg) or saline was administrated into the right atrium. Defibrillation was attempted by a single 150 J shock after 5 min of CPR. Hemodynamics were recorded continuously and sublingual microcirculation was assessed with the orthogonal polarisation spectral (OPS) at baseline (BL), 1, 5 min of CPR and 1, 5 min after resuscitation. Results: All animals were resuscitated successfully resuscitated. There were no differences in coronary perfusion pressure (CPP), end-tidal carbon dioxide (ETCO 2 ) between the two groups (Figure 1). Sublingual perfused vessel density (PVD) and microcirculatory flow index (MFI) were significantly better in NTG treated animals than those of control animals during and after CPR. Conclusion: Administration of nitroglycerin at the onset of CPR improves microcirculation without undesirable effects on macrocirculation during and after resuscitation.
Pattern of Mutational Changes in Patients with Chronic Phase CML Who Are Treated with Frontline TKI and Transform to Blast Phase CML
Authors: Preetesh Jain, Rashmi Kanagal-Shamanna, Hagop M. Kantarjian, F. Anthony San Lucas, Ahmad Ghorab, Elias J. Jabbour, Issa Ghayas, Koji Sasaki, Tapan Kadia, Zeev Estrov, Farhad Ravandi, Jorge E. Cortes
Journal: Blood (2017)
The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning
Authors: Zikai Zhou, An Liu, Shuting Xia, Celeste Leung, Junxia Qi, Yanghong Meng, Wei Xie, Pojeong Park, Graham L. Collingridge, Zhengping Jia
Journal: Nature Neuroscience (2017)
The Effect of Telemedicine Follow-up Care on Diabetes-Related Foot Ulcers: A Cluster-Randomized Controlled Noninferiority Trial
Authors: Hilde Smith-Strøm, Jannicke Igland, Truls Østbye, Grethe S. Tell, Marie F. Hausken, Marit Graue, Svein Skeie, John G. Cooper, Marjolein M. Iversen
Journal: Diabetes Care (2017)

OBJECTIVE To evaluate whether telemedicine (TM) follow-up of patients with diabetes-related foot ulcers (DFUs) in primary health care in collaboration with specialist health care was noninferior to standard outpatient care (SOC) for ulcer healing time. Further, we sought to evaluate whether the proportion of amputations, deaths, number of consultations per month, and patient satisfaction differed between the two groups. RESEARCH DESIGN AND METHODS Patients with DFUs were recruited from three clinical sites in western Norway (2012–2016). The cluster-randomized controlled noninferiority trial included 182 adults (94/88 in the TM/SOC groups) in 42 municipalities/districts. The intervention group received TM follow-up care in the community; the control group received SOC. The primary end point was healing time. Secondary end points were amputation, death, number of consultations per month, and patient satisfaction. RESULTS Using mixed-effects regression analysis, we found that TM was noninferior to SOC regarding healing time (mean difference –0.43 months, 95% CI −1.50, 0.65). When competing risk from death and amputation were taken into account, there was no significant difference in healing time between the groups (subhazard ratio 1.16, 95% CI 0.85, 1.59). The TM group had a significantly lower proportion of amputations (mean difference –8.3%, 95% CI –16.3%, –0.5%), and there were no significant differences in the proportion of deaths, number of consultations, or patient satisfaction between groups, although the direction of the effect estimates for these clinical outcomes favored the TM group. CONCLUSIONS The results suggest that use of TM technology can be a relevant alternative and supplement to usual care, at least for patients with more superficial ulcers.
La rubéole en Angleterre, Ecosse et Pays de Galles
Authors: P Tookey
Journal: Eurosurveillance (2004)

La vaccination contre la rubeole pour les jeunes filles d'âge scolaire a ete introduite en 1970 au Royaume-Uni, suivie d'autres mesures dans les annees 1970 : le test prenatal et la vaccination postpartum pour les femmes susceptibles de contracter la maladie. La vaccination Rougeole-oreillons-rubeole (ROR) a grande echelle pour les enfants de 12 a 15 mois a debute en 1988 ; le programme de vaccination pour les filles d'âge scolaire a ete arrete en 1996 pour etre remplace par une deuxieme dose de ROR pour les enfants d'âge pre-scolaire. En revanche la vaccination apres accouchement des femmes non immunisees identifiees par le test prenatal reste programmee. En 1988, la rubeole est devenue une maladie a declaration obligatoire, dont la surveillance est effectuee par des rapports cliniques et biologiques. Des donnees sont disponibles sur les interruptions de grossesse liees a la rubeole, les naissances d'enfants atteints de rubeole congenitale (RC), la susceptibilite a la rubeole dans des sous-groupes de population et les vaccinations. Les notifications de cas de rubeole ont baisse d'environ 50 par an entre 1971-75 a un peu plus de 20 par an en 1986-90, et les interruptions de grossesse sont passees d'une moyenne de 750 par an a 50. Depuis 1991, environ 40 nouveaux-nes presentant une RC ont ete declares; les meres avaient ete contaminees a l'etranger pour le tiers d'entre elles, dans leur pays d'origine pour la plupart (infections importees), un tiers etaient nees a l'etranger mais avaient ete contaminees au Royaume-Uni, et un tiers etaient nees au Royaume-Uni. Les femmes vivant au Royaume-Uni mais nees a l'etranger sont beaucoup plus susceptibles a la rubeole que les femmes nees au Royaume-Uni. Bien que la circulation du virus de la rubeole soit actuellement tres reduite, la prise de vaccin ROR a chute de plus de 10% depuis 1995. Si le virus recommencait a circuler, les femmes immigrees auraient un risque accru d'etre contaminees par la rubeole pendant leur grossesse.
Multiband mucosectomy for the treatment of challenging non-pedunculated colorectal polyps
Authors: Joaquín Rodríguez-Sánchez, Eva De la Santa Belda, Pilar Olivencia Palomar, Margarita Úbeda Muñoz, José Olmedo Camacho
Journal: Endoscopy (2017)

Endoscopic mucosal resection is the gold standard treatment for non-pedunculated colorectal polyps; however, some specific situations (location behind folds, scarred or flat morphology) can make this technique challenging. We aimed to assess the efficacy and safety of multiband mucosectomy (MBM) for resection of non-pedunculated colorectal polyps.This was a retrospective study of patients in whom MBM was performed to resect large non-pedunculated colorectal polyps. All procedures were carried out using the Shooter multiband ligator kit (Cook Medical, Limerick, Ireland). A 3-month follow-up colonoscopy was performed in all patients.10 patients underwent MBM for resection of 10 large (median 33.5 mm) non-pedunculated polyps. A total of 45 MBM sessions were carried out to resect all of the lesions using on average one rubber band per 1.5 cm2 of resected tissue. Complete resection was possible in 9 out of 10 lesions, although en bloc resection was only feasible in one lesion. Follow-up colonoscopy revealed residual adenoma in just one patient. No major complications were registered.In this small series of patients, MBM proved to be a safe and effective endoscopic resection technique for challenging non-pedunculated colorectal polyps.
Identification of H3K4me1-associated proteins at mammalian enhancers
Authors: Andrea Local, Hui Huang, Claudio P. Albuquerque, Namit Singh, Ah Young Lee, Wei Wang, Chaochen Wang, Judy E. Hsia, Andrew K. Shiau, Kai Ge, Kevin D. Corbett, Dong Wang, Huilin Zhou, Bing Ren
Journal: Nature Genetics (2017)
Association between Loss of Skeletal Muscle Mass and Mortality and Tumor Recurrence in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Authors: Ke-Vin Chang, Jin-De Chen, Wei-Ting Wu, Kuo-Chin Huang, Chia-Tzu Hsu, Der-Sheng Han
Journal: Liver Cancer (2017)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Hepatocellular carcinoma (HCC) has multiple prognostic factors, and there is an increase in knowledge about the body composition and physical status of patients with HCC. The present meta-analysis aimed to explore whether loss of skeletal muscle mass is associated with mortality and tumor recurrence in patients with HCC. &lt;b&gt;&lt;i&gt;Method:&lt;/i&gt;&lt;/b&gt; A systematic search was conducted for published literature using PubMed, Embase, and Scopus. We included cohort or case-control studies investigating patients with HCC. The primary and secondary outcomes were the associations of loss of skeletal muscle mass with overall survival and tumor recurrence, respectively, expressed by a summary hazard ratio (HR) and 95% confidence interval (CI). &lt;b&gt;&lt;i&gt;Result:&lt;/i&gt;&lt;/b&gt; A total of 13 studies comprising 3,111 patients were included. The summary HRs calculated by either univariate or multivariate analysis both suggested a significant association between sarcopenia and all-cause mortality (crude HR = 2.04, 95% CI: 1.74-2.38; adjusted HR = 1.95, 95% CI: 1.60-2.37). Similarly, loss of skeletal muscle mass was associated with tumor recurrence (crude HR = 1.85, 95% CI: 1.44-2.37; adjusted HR = 1.76, 95% CI: 1.27-2.45). The stratified analysis showed that treatment types and inclusion of body mass index or body weight in the Cox regression model did not modify both clinical outcomes. With an increase in cut-off values of muscle mass on computed tomography images (especially for male patients), there was an insignificant trend of stronger associations between loss of skeletal muscle mass and all-cause mortality. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Loss of skeletal muscle mass is associated with increased all-cause mortality and tumor recurrence in patients with HCC. Further prospective studies incorporating measurements of muscle strength and physical function are warranted to see whether inclusion of both parameters better predicts the outcome than use of muscle mass only.
Early relapse after autologous hematopoietic cell transplantation remains a poor prognostic factor in multiple myeloma but outcomes have improved over time
Authors: S K Kumar, A Dispenzieri, R Fraser, F Mingwei, G Akpek, R Cornell, M Kharfan-Dabaja, C Freytes, S Hashmi, G Hildebrandt, L Holmberg, R Kyle, H Lazarus, C Lee, J Mikhael, T Nishihori, J Tay, S Usmani, D Vesole, R Vij, B Wirk, A Krishnan, C Gasparetto, T Mark, Y Nieto, P Hari, A D'Souza
Journal: Leukemia (2017)
Abstract 8898: Gender Difference in Right Ventricular Diastolic Function in Normal Subjects
Authors: Takenori Otsuka, Makoto Suzuki, Hisao Yoshikawa, Gou Hashimoto, Youko Ishikawa, Takako Ishida, Tsukasa Osaki, Naoshi Itou, Tsuyoshi Ono, Masato Yamamoto, Masato Nakamura, Kaoru Sugi
Journal: Circulation (2011)

Background: Normative Doppler values and determinants for gender difference of right ventricular diastolic function in healthy subjects have not been fully elucidated. The purpose of this study is to verify the difference of right ventricular diastolic function between men and women at each age. Method: One hundred sixty nine male and 221 female in healthy subject, aged 20 to 90, were examined by both tricuspid inflow velocity and tricuspid annulus velocity by tissue Doppler imaging. All subjects were divided into 7 groups as 20s, 30s, 40s, 50s, 60s,70s, 80s depend on their age. Results :The tricuspid E velocity was significantly decreased with age(p&lt;0.0001). But E velocitywas no differences significantly in all generation between men and women. The tricuspid A velocity was significantly increased with age(p&lt;0.0001). But A velocity was no differences significantly in all generation between men and women (Table). Ratio of tricuspid E and A velocity (E/A) was significantly decreased with age.But no differences were observed in ratio of E/A in all generation between men and women. (20s: 2.0±0.6 vs 2.5±0.6 p=0.03,30s: 1.9±0.5 vs 2.1±0.5 p=NS, 40s: 1.6±0.4 vs 1.9±0.5 p=NS, 50s: 1.3±0.3 vs 1.5±0.4p=NS, 60s: 1.2±0.2 vs 1.2±0.3 p=NS, 70s: 1.1±0.3 vs 1.1±0.3 p=NS, 80s: 1.2±0.3vs 1.2±0.3 p=NS, total: 1.4±0.5 vs 1.5±0.6 p=NS). Early diastole velocity of tricuspid annulus (Ea) by tissue Doppler method was significantly decreased with age (p&lt;0.0001). But Ea was no differences significantly in all generation between men and women (Table). Conclusions: Our results provide the normative Doppler values of right ventricular diastolic function for age decades. The assessment of right ventricular diastolic function obtained from Doppler method should be considered their age. There was no differences significantly of right ventricular diastolic function between men and women.
Abstract 19996: Cardiac Mesenchymal Stem Cells With High Endogenous Gata4 Promoter Activity Have Superior Capacity to Elicit Cardiac Repair
Authors: Yingjie Wang, Jack Rubinstein, Xiaolong Wang, Il-man Kim, Muhammad Ashraf, Neal Weintraub, Yaoliang Tang
Journal: Circulation (2016)

Introduction:  Given the limited success to date in using non-specific membrane makers, in identifying cardiac stem cells, the significance of finding a much more potential cardiac mesenchymal stem cell (C-MSC) maker from transcription factors in nuclear is very important.   Hypothesis:  We want to test the feasibility of using GATA4, an early cardiac-specific transcription factor, as biomarker to identify a subpopulation of C-MSC that could be highly efficacious for cardiovascular repair.   Methods:  A lentiviral vector in which the expression of eGFP reporter is driven by a 1kb fragment of the mouse GATA4 promoter was constructed. Murine C-MSC with high GFP intensity were sorted by FACS.   Results:  Western blot shows that the C-MSC population with high GFP intensity exhibits higher GATA4 protein expression as compared with unsorted C-MSC. Interestingly, we observed that sorted GATA4high C-MSC also exhibit higher HIF-1α protein expression as compared with unsorted C-MSC. We compared hypoxia- and serum deprivation induced-apoptosis between sorted GATA4high and unsorted C-MSC by TUNEL staining. We found that the GATA4high exhibited lower rate of TUNEL positivity as compared with unsorted C-MSC, suggesting GATA4high C-MSC are more resistant to hypoxia- and serum deprivation-induced apoptosis in comparison with unsorted C-MSC. In mouse model of myocardial infarction by permanent left coronary ligation, GATA4high C-MSC or unsorted C-MSC was injected into the border zone area. Left ventricular ejection fraction (EF) were serially (days 1 and 14) assessed using echocardiography. At day 1, no differences in EF were observed between GATA4high C-MSC and unsorted C-MSC group (n=9, ns). At day 14, left ventricular ejection fraction in GATA4high C-MSC cell-treated group was improved about 11.2% compared with the unsorted C-MSC group (n=9, P   Conclusions:  Our results suggest that GATA4high, as compared with unsorted C-MSC, exhibit enhanced survival capacity which will consequently lead to improvement of heart contractile function in the infarcted heart, therefore, GATA4high C-MSC can be considered as a much more potential progenitor for heart repair.
Is Surgical Clip Placement Necessary in all Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy, and Could This Have Financial Implications for Local Trusts?
Authors: S. Chambers, E. Griffin, L. Jenkins, S. Ayaani, H. Al-Omishy, S. Robertson, M. Sreenivas, A. Tomlins, K. McEvoy
Journal: International Journal of Surgery (2017)