tbuckley/cabot-search huggingface dataset:
Safety of Estradiol Treatment in Perimenopausal Asymptomatic Women
Authors: Justine Hugon-Rodin, Gaelle Amand, Geneviéve Plu-Bureau
Journal: JAMA Psychiatry (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Caffeine-catalyzed gels
Authors: Angela M. DiCiccio, Young-Ah Lucy Lee, Dean L. Glettig, Elizabeth S.E. Walton, Eva L. de la Serna, Veronica A. Montgomery, Tyler M. Grant, Robert Langer, Giovanni Traverso
Journal: Biomaterials (2018)

Covalently cross-linked gels are utilized in a broad range of biomedical applications though their synthesis often compromises easy implementation. Cross-linking reactions commonly utilize catalysts or conditions that can damage biologics and sensitive compounds, producing materials that require extensive post processing to achieve acceptable biocompatibility. As an alternative, we report a batch synthesis platform to produce covalently cross-linked materials appropriate for direct biomedical application enabled by green chemistry and commonly available food grade ingredients. Using caffeine, a mild base, to catalyze anhydrous carboxylate ring-opening of diglycidyl-ether functionalized monomers with citric acid as a tri-functional crosslinking agent we introduce a novel poly(ester-ether) gel synthesis platform. We demonstrate that biocompatible Caffeine Catalyzed Gels (CCGs) exhibit dynamic physical, chemical, and mechanical properties, which can be tailored in shape, surface texture, solvent response, cargo release, shear and tensile strength, among other potential attributes. The demonstrated versatility, low cost and facile synthesis of these CCGs renders them appropriate for a broad range of customized engineering applications including drug delivery constructs, tissue engineering scaffolds, and medical devices.
Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer
Authors: Bowen Liu, Tianjiao Wang, Huawei Wang, Lu Zhang, Feifei Xu, Runping Fang, Leilei Li, Xiaoli Cai, Yue Wu, Weiying Zhang, Lihong Ye
Journal: Journal of Hematology & Oncology (2018)

Resistance to tamoxifen (TAM) frequently occurs in the treatment of estrogen receptor positive (ER+) breast cancer. Accumulating evidences indicate that transcription factor HOXB13 is of great significance in TAM resistance. However, the regulation of HOXB13 in TAM-resistant breast cancer remains largely unexplored. Here, we were interested in the potential effect of HBXIP, an oncoprotein involved in the acceleration of cancer progression, on the modulation of HOXB13 in TAM resistance of breast cancer.The Kaplan-Meier plotter cancer database and GEO dataset were used to analyze the association between HBXIP expression and relapse-free survival. The correlation of HBXIP and HOXB13 in ER+ breast cancer was assessed by human tissue microarray. Immunoblotting analysis, qRT-PCR assay, immunofluorescence staining, Co-IP assay, ChIP assay, luciferase reporter gene assay, cell viability assay, and colony formation assay were performed to explore the possible molecular mechanism by which HBXIP modulates HOXB13. Cell viability assay, xenograft assay, and immunohistochemistry staining analysis were utilized to evaluate the effect of the HBXIP/HOXB13 axis on the facilitation of TAM resistance in vitro and in vivo.The analysis of the Kaplan-Meier plotter and the GEO dataset showed that mono-TAM-treated breast cancer patients with higher HBXIP expression levels had shorter relapse-free survivals than patients with lower HBXIP expression levels. Overexpression of HBXIP induced TAM resistance in ER+ breast cancer cells. The tissue microarray analysis revealed a positive association between the expression levels of HBXIP and HOXB13 in ER+ breast cancer patients. HBXIP elevated HOXB13 protein level in breast cancer cells. Mechanistically, HBXIP prevented chaperone-mediated autophagy (CMA)-dependent degradation of HOXB13 via enhancement of HOXB13 acetylation at the lysine 277 residue, causing the accumulation of HOXB13. Moreover, HBXIP was able to act as a co-activator of HOXB13 to stimulate interleukin (IL)-6 transcription in the promotion of TAM resistance. Interestingly, aspirin (ASA) suppressed the HBXIP/HOXB13 axis by decreasing HBXIP expression, overcoming TAM resistance in vitro and in vivo.Our study highlights that HBXIP enhances HOXB13 acetylation to prevent HOXB13 degradation and co-activates HOXB13 in the promotion of TAM resistance of breast cancer. Therapeutically, ASA can serve as a potential candidate for reversing TAM resistance by inhibiting HBXIP expression.
Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study
Authors: Angela Huttner, Selidji Todagbe Agnandji, Christophe Combescure, José F Fernandes, Emmanuel Bache Bache, Lumeka Kabwende, Francis Maina Ndungu, Jessica Brosnahan, Thomas P Monath, Barbara Lemaître, Stéphane Grillet, Miriam Botto, Olivier Engler, Jasmine Portmann, Denise Siegrist, Philip Bejon, Peter Silvera, Peter Kremsner, Claire-Anne Siegrist, Sanjeev KRISHNA, Marylyn M. ADDO, Stephan BECKER, Verena KRÄHLING, Patricia NJUGUNA, Marie-Paule KIENY, Rafi AHMED, Jenna ANDERSON, Floriane AUDERSET, Luisa BORGIANNI, Annalisa CIABATTINI, Marielle C. HAKS, Ali HARANDI, Donald Gray HEPPNER, Alice GERLINI, Donata MEDAGLINI, Tom H.M. OTTENHOFF, David PEJOSKI, Mark PAGE, Gianni POZZI, Francesco SANTORO, Sheri DUBEY, José F. FERNANDES, Helder NAKAYA, Fiona OROURKE, Gianni POZZI, Sylvia ROTHENBERGER
Journal: The Lancet Infectious Diseases (2018)
Highly Variable Frequencies of Donor Antigen-Specific Naive Cells May Dictate the Immunogenicity of Minor Histocompatibility Antigens after Hematopoietic Stem Cell Transplantation
Authors: Anna Kuchmiy, Savely Sheetikov, Dmitrii Romaniuk, Anna Postovskaya, Sergey Filkin, Nadia Bykova, Grigory Efimov, Valeriy G. Savchenko
Journal: Blood (2017)
Abstract 11597: Voluntary and Occupational Physical Activity Have Different Effects on Mortality
Authors: Martin Bahls, Sebastian Baumeister, Henry Völzke, Sven Gläser, Michael Leitzmann, Stephan B Felix, Marcus Dörr
Journal: Circulation (2015)

Introduction: Animal studies suggest oppositional effects for voluntary and involuntary physical activity (PA). To assess this in humans, we used distinct domains of PA (sports, leisure time, work) as well as physical fitness and associated these variables with all-cause, cardiovascular (CVD) and cancer mortality in a large population-based cohort. Methods: Data of 2,925 participants from the Study of Health in Pomerania (SHIP-1) were used [median age: 48 (interquartile range (IQR): 35, 62) years (y), 52% [[female symbol]]]. All-cause and cause-specific mortality was determined after a median follow-up of 7.0 y (IQR: 5.6 - 6.2). A Sports index (SI), Leisure Time index (LTI) and Work index (WI) were assessed using a modified Baecke questionnaire. Maximal oxygen consumption (VO2peak), oxygen consumption at the anaerobic threshold (VO2@AT), and maximal work load (Wmax) were measured on a bicycle ergometer during symptom-limited cardiopulmonary exercise testing (CPET). Cox models were adjusted for sex, age, smoking, alcohol consumption, years of schooling, income, and body mass index. Results: A total of 156 subjects died due to all-cause, 53 due to CVD and 50 due to cancer after follow-up. After adjustment, SI [hazard ratio (HR) per SD: 0.27; 95%-confidence interval (CI): 0.13; 0.55] and LTI (HR per SD: 0.34; 95%-CI: 0.15; 0.77) were associated with a reduced risk of all-cause mortality. WI was not associated with all-cause mortality. SI was associated with reduced risk of CVD mortality (HR: 0.26; 95%-CI: 0.07; 0.96). All CPET measures were significantly related to reduced risk of all-cause and cancer mortality (VO2peak - all-cause HR per SD: 0.007; 95%-CI: 0.001; 0.057 and cancer HR per SD: 0.011; 95%-CI: 0.005; 0.210; VO2@AT - all-cause HR per SD: 0.047; 95%-CI: 0.001; 0.028 and cancer HR per SD: 0.052; 95%-CI: 0.004; 0.073; Wmax - all-cause HR per SD: 0.012; 95%-CI: 0.002; 0.074 and cancer HR per SD: 0.01; 95%-CI: 0.0007; 0.166). Conclusion: Voluntary PA was associated with a reduced risk for all-cause and CVD mortality, while occupational PA was not. Exercise capacity was inversely related to all-cause and cancer mortality. Our results indicate that the benefits of PA may be limited to voluntary PA. Thus, questionnaires need to differentiate between voluntary and occupational PA.
Bystro: rapid online variant annotation and natural-language filtering at whole-genome scale
Authors: Alex V. Kotlar, Cristina E. Trevino, Michael E. Zwick, David J. Cutler, Thomas S. Wingo
Journal: Genome biology (2018)

Accurately selecting relevant alleles in large sequencing experiments remains technically challenging. Bystro ( https://bystro.io/ ) is the first online, cloud-based application that makes variant annotation and filtering accessible to all researchers for terabyte-sized whole-genome experiments containing thousands of samples. Its key innovation is a general-purpose, natural-language search engine that enables users to identify and export alleles and samples of interest in milliseconds. The search engine dramatically simplifies complex filtering tasks that previously required programming experience or specialty command-line programs. Critically, Bystro’s annotation and filtering capabilities are orders of magnitude faster than previous solutions, saving weeks of processing time for large experiments.
国内薬用植物園で植培されるカンゾウ属植物の調査と優良品種選抜のための基礎研究.1 地上部のHPLCパターンと成分による比較
Authors: 芝野真喜雄, 松本吉広, 草野源次郎, 柴田敏郎
Journal: Nature Medicine (1996)
Therapeutic encounters and the elicitation of community care
Authors: Leander Steinkopf, Mícheál de Barra
Journal: Behavioral and Brain Sciences (2018)

Abstract Singh's analysis of shamanism is regarded as a contribution to the evolutionary study of healing encounters and evolutionary medicine. Shamans must create convincing healing spectacles, while sick individuals must convincingly express symptoms and suffering to motivate community care. Both have a shared interest in convincing onlookers. This is not restricted to shamanic treatment, but is still true in modern medical care.
Evidence-Based Rationale for Use of Inferior Vena Cava Filters
Authors: Eric K. Hoffer
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Rapid Deployment Versus Conventional Bioprosthetic Valve Replacement for Aortic Stenosis
Authors: Stephan Ensminger, Buntaro Fujita, Timm Bauer, Helge Möllmann, Andreas Beckmann, Raffi Bekeredjian, Sabine Bleiziffer, Sandra Landwehr, Christian W. Hamm, Friedrich W. Mohr, Hugo A. Katus, Wolfgang Harringer, Thomas Walther, Christian Frerker
Journal: Journal of the American College of Cardiology (2018)
Abstract P361: Inflammatory Burden May Partially Mediate the Relationship Between Everyday Discrimination and Carotid Plaque Height in Midlife Women
Authors: Natalie Suder Egnot, Emma Barinas-Mitchell, Trevor Orchard, Christina Wassel, Maria Brooks, Suresh Mulukutla, Rebecca Thurston
Journal: Circulation (2018)

Introduction: Self-reported experiences of discrimination have been associated with greater risk of incident cardiovascular events and all-cause mortality across racial/ethnic groups. However, questions remain regarding the potential mechanisms through which perceived discrimination may influence cardiovascular risk. Furthermore, the relationship between self-reported discrimination with markers of subclinical cardiovascular disease (CVD) such as atherosclerotic plaque presence, burden, and characteristics remains unclear. We hypothesized that perceived discrimination is associated with subclinical measures of carotid atherosclerosis indicative of greater CVD risk and that inflammation is a mechanism contributing to this relationship. Methods: Late peri- and postmenopausal women without clinical CVD (n=300) completed the Everyday Discrimination Scale, developed in order to assess day-to-day experiences of interpersonal mistreatment, and underwent B-mode ultrasound to assess carotid atherosclerosis. Associations between everyday discrimination and measures of carotid plaque presence, burden (total number of plaques, total plaque area), and characteristics (maximum height, grey-scale median, and calcification) were evaluated using linear and logistic regression models adjusted for demographics, as well as CVD and psychosocial risk factors. Overall circulating inflammatory burden, comprising C-reactive protein, interleukin-6, and fibrinogen was identified via exploratory factor analysis and was evaluated as a potential mediator of the relationship between everyday discrimination and subclinical CVD through the ratio of the natural indirect effect and the total effect by inverse probability weighting. Results: The sample was predominately white (72% white (n=216); 22% black (n=66)), nearly half the women (n=138) had at least one carotid plaque, and 40% (n=120) reported experiencing high levels of everyday discrimination. After adjustment, women who reported high levels of discrimination had a maximum carotid plaque height 0.29 mm higher (p=0.03) than those who reported lower levels of discrimination. Circulating inflammatory burden was identified as a partial mediator of the relationship between high discrimination and carotid plaque height explaining 31% of the relationship. There were no significant associations of plaque presence, burden, or other plaque characteristics with discrimination, and the results did not vary by race/ethnicity. Conclusions: These findings add to the growing evidence that perceived discrimination may be associated with elevated cardiovascular disease risk among women of various racial/ethnic groups. These results suggest that increased inflammatory burden may be a mechanism through which experiences of discrimination may be associated with the development of atherosclerosis in midlife women.
CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma
Authors: Daisuke Shiraishi, Yukio Fujiwara, Hasita Horlad, Yoichi Saito, Toyohisa Iriki, Junko Tsuboki, Pan Cheng, Naomi Nakagata, Hiroshi Mizuta, Hirofumi Bekki, Yasuharu Nakashima, Yoshinao Oda, Motohiro Takeya, Yoshihiro Komohara
Journal: Cancer Research (2018)

Recent findings have shown the significance of CD163-positive macrophages in tumor progression, yet there have been few studies on the function of CD163 in macrophages. Here, we uncover the role of CD163 in macrophage activation using CD163-deficient mice and human samples. We detected CD163 in 62 undifferentiated pleomorphic sarcoma samples, in which a high percentage of CD163-positive macrophages was associated with decreased overall survival and higher histologic grade. We observed macrophage-induced tumor cell proliferation in cocultures of human monocyte-derived macrophages and leiomyosarcoma (TYLMS-1) and myxofibrosarcoma (NMFH-1) cell lines, which was abrogated by silencing of CD163. Tumor development of sarcoma (MCA205 and LM8) cells in CD163-deficient mice was significantly abrogated in comparison with wild-type (WT) mice. Coculture with WT peritoneal macrophages significantly increased proliferation of MCA205 cells but decreased in the presence of CD163-deficient macrophages. Production of IL6 and CXCL2 in CD163-deficient macrophages was suppressed in comparison with WT macrophages, and overexpression of CD163 in CD163-deficient macrophages induced production of IL6 and CXCL2. Silencing of IL6 but not CXCL2 abrogated macrophage-induced proliferation of MCA205 cells. Taken together, our results show that CD163 is involved in protumoral activation of macrophages and subsequent development and progression of tumors in mice and humans.Significance: Macrophage CD163-mediated induction of IL6 promotes tumor development and progression in murine and human malignant tumors. Cancer Res; 78(12); 3255-66. ©2018 AACR.
Polyethylene glycol functionalized carbon nanotubes/gelatin-chitosan nanocomposite: An approach for significant drug release
Authors: Sadia Sharmeen, A.F.M. Mustafizur Rahman, Mostakima M. Lubna, Kh Samaher Salem, Rafiqul Islam, Mubarak A. Khan
Journal: Bioactive Materials (2018)

This research work blooms the new idea of developing a safe and controlled drug releasing matrix using multi-walled carbon nanotubes (MWCNTs). In aqueous solution, uniform and highly stable dispersion of MWCNTs was obtained after secondary functionalization with polyethylene glycol (PEG) which was studied by Fourier transmission infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). Solution casting method was used to prepare MWCNTs/gelatin-chitosan nanocomposite films and the effect of MWCNTs on physico-mechanical, thermal and water uptake properties of the nanocomposites were evaluated. Incorporation of MWCNTs into the porous gelatin-chitosan matrix showed interesting stiffness and dampness along with developed microfibrillar structures within the pore walls intended at being used in tissue engineering of bone or cartilage. A common antibiotic drug, ciprofloxacin was incorporated into nanocomposite matrix. The evaluation of the effect of MWCNTs on drug release rate by dissolution test and antimicrobial susceptibility test was performed. Sharp release of the drug was found at early stages (∼1 h), but the rate was reduced afterwards, showing a sustained release. It was observed that for all microorganisms, the antibacterial activities of drug loaded MWCNTs/gelatin-chitosan nanocomposites were higher than that of drug loaded gelatin-chitosan composite films containing no MWCNTs. Comparative statistical studies by ANOVA techniques also showed remarkable difference between the antibacterial activities, exhibited by MWCNTs-incorporated and non-incorporated composite films.
One-Hour Plasma Glucose Compared With Two-Hour Plasma Glucose in Relation to Diabetic Retinopathy in American Indians
Authors: Ethan Paddock, Helen C. Looker, Paolo Piaggi, William C. Knowler, Jonathan Krakoff, Douglas C. Chang
Journal: Diabetes Care (2018)

OBJECTIVEWe compared the ability of 1-and 2-h plasma glucose concentrations (1h-PG and 2h-PG, respectively), derived from a 75-g oral glucose tolerance test (OGTT), to predict retinopathy.1h-PG and 2h-PG concentrations, measured in a longitudinal study of an American Indian community in the southwestern U.S., a population at high risk for type 2 diabetes, were analyzed to assess the usefulness of the 1h-PG to identify risk of diabetic retinopathy (DR). RESEARCH DESIGN AND METHODSCross-sectional (n = 2,895) and longitudinal (n = 1,703) cohorts were assessed for the prevalence and incidence of DR, respectively, in relation to deciles of 1h-PG and 2h-PG concentrations.Areas under the receiver operating characteristic (ROC) curves for 1h-PG and 2h-PG were compared with regard to predicting DR, as assessed by direct ophthalmoscopy. RESULTSPrevalence and incidence of DR, based on direct ophthalmoscopy, changed in a similar manner across the distributions of 1h-PG and 2h-PG concentrations.ROC analysis showed that 1h-PG and 2h-PG were of similar value in identifying prevalent and incident DR using direct ophthalmoscopy.1h-PG cut points of 230 and 173 mg/dL were comparable to 2h-PG cut points of 200 mg/dL (type 2 diabetes) and 140 mg/dL (impaired glucose tolerance), respectively.CONCLUSIONS 1h-PG is a useful predictor of retinopathy risk, has a predictive value similar to that of 2h-PG, and may be considered as an alternative glucose time point during an OGTT.Hyperglycemia assessed by the oral glucose tolerance test (OGTT) is a well-accepted method for identifying individuals with type 2 diabetes and those at risk of developing type 2 diabetes (1).Current World Health Organization (WHO) (2) or American Diabetes Association (ADA) criteria (1) do not use 1-h plasma glucose (1h-PG) to identify those at elevated risk for a diagnosis of type 2 diabetes.However, the potential contribution of 1h-PG was previously appreciated, as shown by inclusion of 1h-PG in the 1979 National Diabetes Data Group criteria for identifying impaired glucose tolerance (IGT) and diabetes (3).Although some investigators preferred using 1h-PG