Impact of the Clinical Frailty Scale on Outcomes After Transcatheter Aortic Valve Replacement
Authors: Tetsuro Shimura, Masanori Yamamoto, Seiji Kano, Ai Kagase, Atsuko Kodama, Yutaka Koyama, Etsuo Tsuchikane, Takahiko Suzuki, Toshiaki Otsuka, Shun Kohsaka, Norio Tada, Futoshi Yamanaka, Toru Naganuma, Motoharu Araki, Shinichi Shirai, Yusuke Watanabe, Kentaro Hayashida, Fumiaki Yashima, Taku Inohara, Yuki Kakefuda, Takahide Arai, Ryo Yanagisawa, Makoto Tanaka, Takashi Kawakami, Yuichiro Maekawa, Kohno Takashi, Akihiro Yoshitake, Yasunori Iida, Masataka Yamazaki, Hideyuki Shimizu, Yoshitake Yamada, Masahiro Jinzaki, Hikaru Tsuruta, Yuji Itabashi, Mitsushige Murata, Michiyuki Kawakami, Shogo Fukui, Motoaki Sano, Keiichi Fukuda, Soh Hosoba, Hirotomo Sato, Tomohiko Teramoto, Masashi Kimura, Mitsuru Sago, Tatsuya Tsunaki, Shoko Watarai, Masanao Tsuzuki, Keisuke Irokawa, Kazuki Shimizu, Toshihiro Kobayashi, Yasuhide Okawa, Masaki Miyasaka, Yusuke Enta, Koki Shishido, Tomoki Ochiai, Tsuyoshi Yamabe, Kenichiro Noguchi, Shigeru Saito, Hiroyoshi Kawamoto, Hirokazu Onishi, Hiroto Yabushita, Satoru Mitomo, Sunao Nakamura, Masahiro Yamawaki, Yui Akatsu, Yosuke Honda, Takuro Takama, Akihito Isotani, Masaomi Hayashi, Norihiko Kamioka, Mizuki Miura, Takashi Morinaga, Tomohiro Kawaguchi, Mariko Yano, Michiya Hanyu, Yoshio Arai, Hideki Tsubota, Masafumi Kudo, Yuki Kuroda, Akihisa Kataoka, Hitofumi Hioki, Yugo Nara, Hideyuki Kawashima, Fukuko Nagura, Makoto Nakashima, Kazuya Sasaki, Junichi Nishikawa, Tomoki Shimokawa, Tadanori Harada, Ken Kozuma
Journal: Circulation (2017)

The semiquantitative Clinical Frailty Scale (CFS) is a simple tool to assess patients' frailty and has been shown to correlate with mortality in elderly patients even when evaluated by nongeriatricians. The aim of the current study was to determine the prognostic value of CFS in patients who underwent transcatheter aortic valve replacement.We utilized the OCEAN (Optimized Catheter Valvular Intervention) Japanese multicenter registry to review data of 1215 patients who underwent transcatheter aortic valve replacement. Patients were categorized into 5 groups based on the CFS stages: CFS 1-3, CFS 4, CFS 5, CFS 6, and CFS ≥7. We subsequently evaluated the relationship between CFS grading and other indicators of frailty, including body mass index, serum albumin, gait speed, and mean hand grip. We also assessed differences in baseline characteristics, procedural outcomes, and early and midterm mortality among the 5 groups.Patient distribution into the 5 CFS groups was as follows: 38.0% (CFS 1-3), 32.9% (CFS4), 15.1% (CFS 5), 10.0% (CFS 6), and 4.0% (CFS ≥7). The CFS grade showed significant correlation with body mass index (Spearman's ρ=-0.077, P=0.007), albumin (ρ=-0.22, P<0.001), gait speed (ρ=-0.28, P<0.001), and grip strength (ρ=-0.26, P<0.001). Cumulative 1-year mortality increased with increasing CFS stage (7.2%, 8.6%. 15.7%, 16.9%, 44.1%, P<0.001). In a Cox regression multivariate analysis, the CFS (per 1 category increase) was an independent predictive factor of increased late cumulative mortality risk (hazard ratio, 1.28; 95% confidence interval, 1.10-1.49; P<0.001).In addition to reflecting the degree of frailty, the CFS was a useful marker for predicting late mortality in an elderly transcatheter aortic valve replacement cohort.