tbuckley/cabot-search huggingface dataset:
Potentially Avoidable Surgical Intensive Care Unit Admissions and Disposition Delays
Authors: Navpreet K. Dhillon, Ara Ko, Eric J. T. Smith, Mayumi Kharabi, Joseph Castongia, Michael Nurok, Bruce L. Gewertz, Eric J. Ley
Journal: JAMA Surgery (2017)

High health care costs encourage initiatives that avoid overuse of resources and identify opportunities to promote appropriate care.To investigate the causes of potentially avoidable surgical intensive care unit (SICU) admissions and disposition delays to determine whether targeted interventions could decrease these stays.This prospective, observational study focused on potentially avoidable SICU days, as determined by observers with input from the rounding intensivists at a 24-bed open SICU at an urban, academic hospital. The preintervention phase occurred from April 6 through June 21, 2015; after implementation of targeted interventions, the postintervention phase occurred from April 4 through June 28, 2016. Data collected included demographic characteristics, reason for admission, and length of stay. All patients admitted to the SICU during the preintervention and postintervention phases were included in the analysis.Based on results collected in the preintervention phase, targeted interventions were designed and implemented from July 1, 2015, through March 31, 2016, including (1) reducing SICU care for minor traumatic brain injury, (2) optimizing postoperative airway management, (3) enhancing communication between services regarding transfers to the SICU, (4) identifying and facilitating more timely end-of-life conversations and supportive care consultations, and (5) encouraging early disposition of patients to floor beds.Changes in the proportion of potentially avoidable SICU days owing to potentially avoidable admissions and/or disposition delays.A total of 459 patients (253 men [55.1%] and 206 women [44.9%]; median age, 62 years [interquartile range, 46-75 years]) were admitted during the preintervention and postintervention phases. Of 261 patients admitted during the preintervention period and 245 during the postintervention period, median SICU and hospital length of stay remained unchanged. A reduction was noted in the percentage of postintervention SICU days owing to potentially avoidable admissions (152 of 1168 days [13%] vs 118 of 1338 days [8.8%]; P = .001) and disposition delays (138 of 1168 days [11.8%] vs 97 of 1338 days [7.2%]; P < .001). During the postintervention period, decreases were noted in the SICU days related to the most common sources of potentially avoidable admissions (SICU stay ≤24 hours, airway concerns, and somnolence) and disposition delays (end-of-life decisions and floor bed unavailable) as well as in the overall rate of potentially avoidable days (269 of 1168 days [23%] vs 205 of 1338 days [15.3%]; P < .001).Nearly one-fourth of SICU days could be categorized as potentially avoidable. Targeted interventions resulted in a significant reduction of potentially avoidable SICU days.
Oligometastatic Stomach Carcinoma From Lung Squamous Cell Carcinoma Detected by 18F-FDG PET/CT
Authors: Wei Wang, Leilei Yuan, Ying Kan, Jigang Yang
Journal: Clinical Nuclear Medicine (2017)

Metastasis from squamous cell carcinoma of the lung to the stomach is extremely rare. F-FDG PET/CT demonstrated intense F-FDG uptake in the lower lobe of the left lung, stomach, and mediastinal lymph node in a 61-year-old man. Lower lobe of the left lung resection, mediastinal lymphadenectomy, partial gastrectomy, and esophagogastric anastomosis was performed. Immunohistochemical studies revealed squamous cell lung carcinoma in the left lung and metastatic carcinoma of gastric and lymph nodes. The present case further demonstrated the value of F-FDG PET/CT in the staging of malignant disease.
Abstract 278: Exercise Training Ameliorates LV Dysfunction in Mice with a Calcium Influx Mediated Cardiomyopathy
Authors: Larry A Barr, Hongyu Zhang, Catherine A Makarewich, Remus M Berretta, Jeffery D Molkentin, Steven R Houser
Journal: Circulation Research (2013)

Background— Ca 2+ influx through L-type Ca 2+ channels (LTCCs) induces Ca 2+ release from the SR to induce and regulate cardiac contraction. We have characterized a mouse model with cardiac-specific expression of the β2a subunit of the LTCC (β2a), leading to pathological hypertrophy due to excessive LTCC Ca 2+ entry. Chronic exercise causes physiological hypertrophy in normal hearts. We determined if swim training improved or further deranged the performance of β2a mice. Methods and Results— β2a (n=12) and WT (n=20) mice were swim trained for 21 consecutive days. ECHO was performed at beginning and end of swim training. Ejection fraction (EF) and fractional shortening (FS) increased significantly with swim training in WT animals. (EF pre-swim: 57±2.02% vs. post-swim: 70±2.88%; FS pre-swim: 30±1.34% vs. post-swim: 39±2.42%). β2a mice were hypercontractile before swimming and had no significant change after training (EF pre-swim: 70±1.75% vs. post-swim: 74.06±2.72%; FS pre-training: 38±2.38% vs. post-training: 42±2.22%). Contractile performance was significantly greater in β2a mice versus WT before but not after training. There was a significant increase in HW/BW [mg/gm] ratio in trained WT (n=8) versus sedentary WT (n=8) (swim: 5.75±0.19 vs. sed: 4.63±0.2) but training did not cause additional hypertrophy in β2a (n=8) versus sedentary (n=7) (swim: 5.98±0.31 vs. sed: 5.96±0.25). Isolated WT and β2a hearts were placed on a Langendorff apparatus and a balloon was inserted into the LV to record isovolumic pressure. Each heart underwent 15 min of ischemia followed by 30 min of reperfusion. End diastolic pressure (EDP) increased in all hearts during ischemia. There were no protective effects of training on ischemia-induced increases in EDP in WT hearts. EDP increased more in sedentary β2a during ischemia but this effect was eliminated in trained β2a hearts. LV developed pressure (LVDP) fell with ischemia and partially recovered with reperfusion. LVDP recovery was significantly greater in trained versus sedentary WT hearts. Swim training also significantly improved LVDP recovery in β2a hearts. Conclusions— Chronic exercise training reduces pathological hypertrophy and damaging effects of ischemia in a murine model of LTCC overexpression.
A gene encoding maize caffeoyl-CoA O-methyltransferase confers quantitative resistance to multiple pathogens
Authors: Qin Yang, Yijian He, Mercy Kabahuma, Timothy Chaya, Amy Kelly, Eli Borrego, Yang Bian, Farid El Kasmi, Li Yang, Paulo Teixeira, Judith Kolkman, Rebecca Nelson, Michael Kolomiets, Jeffery L Dangl, Randall Wisser, Jeffrey Caplan, Xu Li, Nick Lauter, Peter Balint-Kurti
Journal: Nature Genetics (2017)
Next-generation sequencing to monitor the spread of antimicrobial resistance
Authors: Michael Otto
Journal: Genome Medicine (2017)

Next-generation sequencing is increasingly being used to monitor current and historic events related to the emergence and spread of antimicrobial resistance. In a recent publication, researchers analyzed the rise of methicillin-resistant Staphylococcus aureus in the 1960s, emphasizing that adaptations conferring antibiotic resistance might pre-date the introduction of novel antibiotic derivatives. Other researchers have evaluated the role of transmission within a healthcare network, using the example of extended-spectrum beta-lactamase-resistant Escherichia coli.Please see related Genome Biology Research article: www.dx.doi.org/10.1186/s13059-017-1252-9 and Genome Medicine Research article: www.dx.doi.org/10.1186/s13073-017-0457-6.
The incorporation of rituximab (R) and liposomal doxorubicin (LD) into CODOX-m/IVAC for untreated Burkitt lymphoma (BL): Final results of a prospective multicenter phase II study.
Authors: Andrew M. Evens, Kenneth Robert Carson, Chadi Nabhan, Nahida Islam, Borko Jovanovic, Paul M. Barr, Paolo Fabrizio Caimi, Lillia Gallot, Stephanie A. Gregory, Leo I. Gordon
Journal: Journal of Clinical Oncology (2012)

8080 Background: Two-year survival rates remain &lt;65-70% for adult BL. Further, there is a paucity of data examining the addition of R with CODOX-M/IVAC. Methods: 25 patients (pts) with classic BL enrolled onto this phase II study (3/07-4/11). Pts were classified as low risk (LR) or high risk (HR); LR received 3 CODOX-M, while HR had 4 alternating CODOX-M/IVAC (Mead et al, Blood 2008). LD (40 mg/m 2 ) was used in lieu of doxorubicin, while intravenous R (500 mg/m 2 ) was given days 0 + 8 of CODOX-M and days 0 + 6 of IVAC cycles. Ejection fraction (EF) was assessed at baseline, s/p 2 cycles and completion. Results: Median age was 44 years (yrs) (23-70). There were 20 HR and 5 LR pts; 3 HR and 1 LR pt were HIV+. 15% of HR pts had + CNS disease. In addition, 35% of HR pts had bulk &gt;10 cm and 40% had bone marrow involvement. 24/25 pts were evaluable for toxicity and response. Therapy was completed at a median of 13 weeks (11-20) for HR pts and 10 weeks for LR (9-12). Myelosuppression (62% grade 4 thrombocytopenia, 4% grade 4 anemia) and mucositis (33% grade 3, 13% grade 4) appeared comparable with prior CODOX-M/IVAC data. Other grade 3 toxicities were infection (38%), neutropenic fever (29%), transaminitis (33%), diarrhea (8%), creatinine (8%), seizure (4%), vomiting (4%). Notably, there was no grade 3 or 4 neuropathy. Two grade 2 and three grade 3 cardiac events occurred (all depressed EF, no clinical CHF). Two of the three grade 3 cardiac events occurred in pts age &gt;65 yrs. Among all pts, the median change in EF at baseline vs study end was -2% (-22% to +11%). The overall response rate (modified Cheson with FDG-PET) after 2 cycles was 100% with a 67% complete remission rate. At a median follow-up of 2.3 yrs, 2-year PFS and OS rates for all pts were 86% and 86%, respectively (LR 2-yr PFS and OS: both 100%; HR 2-yr PFS and OS: both 82%). Furthermore, 2-yr PFS and OS for HR, HIV-negative BL were 91% and 91%, respectively (disease-specific survival: 100%). Conclusions: The integration of R and LD into CODOX-M/IVAC for adult BL is feasible and associated with similar tolerability compared with prior reports. Moreover, this regimen was associated with excellent survival rates, especially for HIV-negative BL.
Abstract 203: Sodium Hydrogen Exchanger Isoform Switching And Kchip2 Upregulation In Elderly Porcine Atria
Authors: Ritu Kant, Zhaoyang Hu, Jaideep K Malhotra, Trine Krogh-Madsen, David J Christini, Paul M Heerdt, Geoffrey W Abbott
Journal: Circulation Research (2013)

Aging-associated changes in the heart contribute to a wide variety of cardiovascular diseases. The aging atrium becomes increasingly more susceptible to development of atrial fibrillation, and even its pharmacological response to therapeutic drugs alters over time. Changes in structure, function, and pharmacology of the heart can potentially be tied to specific changes in gene expression with aging. Here, seeking molecular correlates of myocardial aging processes, we performed global “whole transcript” analysis of 25,388 genes using 572,667 probes to compare the left atrium (LA) transcriptomes of young adult (9 months old) versus elderly (10 years old) female Sinclair swine. The two genes exhibiting the largest increase in LA expression with aging were NHE2 (9.2-fold; n = 3-4; P = 0.00001) and KCNIP2 (3.8-fold; n = 3-4; P = 0.0002). Real-time qPCR recapitulated the NHE2 results and revealed strongest upregulation with aging in LA, and age-independent expression in the ventricles. NHE2 encodes sodium hydrogen exchanger isoform 2, which was previously considered to not be expressed in mammalian heart, the favored cardiac isoform being NHE1. NHE1 is considered to be important for reperfusion injury after ischemia but, surprisingly, has been a relatively disappointing therapeutic target in clinical trials. Here, we found NHE1 transcript expression in all chambers, but no upregulation in aging heart, raising the possibility that NHE2 upregulation could negatively impact the pharmacological responsiveness of aging tissue to NHE1-specific inhibitors. KCNIP2 encodes potassium channel beta subunit KChIP2, which tightly regulates Ito density. Real-time qPCR indicated equal KCNIP2 upregulation with aging in the LA and RA, and aging-independent expression in the ventricles. In silico modeling predicted the increased KCNIP2 observed here would increase Ito sufficiently to shorten the atrial refractory period, an established substrate for atrial fibrillation. In sum, the findings uncover potential molecular substrates for aging-associated changes in cardiac function, and suggest possible novel therapeutic avenues for aging-related cardiovascular diseases.
MACRA and Cardiology—The Devil Is in the Details
Authors: Lauren G. Gilstrap, Karen E. Joynt
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Evaluation of Breast-Cancer Therapy as a Guide to Control Programs
Authors: James W. Hawkins
Journal: JNCI Journal of the National Cancer Institute (1944)

Journal Article Evaluation of Breast-Cancer Therapy as a Guide to Control Programs Get access James W. Hawkins James W. Hawkins passed assistant surgeon National Cancer Institute, National Institute of Health, United States Public Health Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 5, April 1944, Pages 445–460, https://doi.org/10.1093/jnci/4.5.445 Published: 01 April 1944
LV Mass Independently Predicts Mortality and Need for Future Revascularization in Patients Undergoing Diagnostic Coronary Angiography
Authors: Ahmed Abdi-Ali, Robert J.H. Miller, Danielle Southern, Mei Zhang, Yoko Mikami, Merril Knudtson, Bobak Heydari, Andrew G. Howarth, Carmen P. Lydell, Mathew T. James, Stephen B. Wilton, James A. White
Journal: JACC. Cardiovascular imaging (2017)
Etv2 as an essential regulator of mesodermal lineage development
Authors: Naoko Koyano-Nakagawa, Daniel J. Garry
Journal: Cardiovascular Research (2017)

The 'master regulatory factors' that position at the top of the genetic hierarchy of lineage determination have been a focus of intense interest, and have been investigated in various systems. Etv2/Etsrp71/ER71 is such a factor that is both necessary and sufficient for the development of haematopoietic and endothelial lineages. As such, genetic ablation of Etv2 leads to complete loss of blood and vessels, and overexpression can convert non-endothelial cells to the endothelial lineage. Understanding such master regulatory role of a lineage is not only a fundamental quest in developmental biology, but also holds immense possibilities in regenerative medicine. To harness its activity and utility for therapeutic interventions, it is essential to understand the regulatory mechanisms, molecular function, and networks that surround Etv2. In this review, we provide a comprehensive overview of Etv2 biology focused on mouse and human systems.
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease
Authors: Kelly R. Stevens, Margaret A. Scull, Vyas Ramanan, Chelsea L. Fortin, Ritika R. Chaturvedi, Kristin A. Knouse, Jing W. Xiao, Canny Fung, Teodelinda Mirabella, Amanda X. Chen, Margaret G. McCue, Michael T. Yang, Heather E. Fleming, Kwanghun Chung, Ype P. de Jong, Christopher S. Chen, Charles M. Rice, Sangeeta N. Bhatia
Journal: Science Translational Medicine (2017)

An engineered microenvironment supports expansion of adult human engineered liver tissue after implantation in a mouse model of liver injury.
Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines
Authors: Emilie Alirol, Teodora E. Wi, Manju Bala, Maria Luiza Bazzo, Xiang-Sheng Chen, Carolyn Deal, Jo-Anne R. Dillon, Ranmini Kularatne, Jutta Heim, Rob Hooft van Huijsduijnen, Edward W. Hook, Monica M. Lahra, David A. Lewis, Francis Ndowa, William M. Shafer, Liz Tayler, Kimberly Workowski, Magnus Unemo, Manica Balasegaram
Journal: PLoS Medicine (2017)

Emilie Alirol and colleagues discuss the development of new treatments for gonorrhea.
CARDIOVASCULAR INCIDENTS, INCLUDING SUDDEN CARDIAC ARRESTS, IN PROFESSIONAL MALE FOOTBALL PLAYERS WITH NEGATIVE PRE-PARTICIPATING CARDIAC SCREENING RESULTS AN 8-YR FOLLOW-UP STUDY
Authors: Hilde Moseby Berge, Thor Einar Andersen, Roald Bahr
Journal: British Journal of Sports Medicine (2017)

Background The aim of preparticipation cardiac screening of athletes is to detect cardiovascular disease at an early stage to prevent sudden cardiac death and sudden cardiac arrest. Few studies focus on consequences of false negative findings. Objective The main objective of this study was to identify cardiovascular incidents in a cohort of male professional football players with negative screening results. Design Retrospective eight years follow-up study. Setting Follow-up of systematic preparticipation cardiac screening completed prior to the 2008 football season of 604 players cleared for full participation in the Norwegian professional leagues, including player and family history, electrocardiography and echocardiography. Patients (or Participants) All players who suffered severe cardiovascular incidents during 8 years of follow-up. Interventions (or Assessment of Risk Factors) Media search with key words football and cardiovascular incidents in Norway from January 1st 2008 until February 13th 2016. We collected medical records from players with disease and compared preparticipation cardiac screening results with outcome. Main Outcome Measurements Players from the original cohort who suffered sudden cardiac death or arrest, angina pectoris or myocardial infarction, transitory ischemic attack, cerebral haemorrhage or infarction, atrial flutter or fibrillation, blood clot, myocarditis or pericarditis. Results Six players with negative screening results, median age 30 years (27–36), had experienced cardiovascular incidents during follow-up. Three players had suffered sudden cardiac arrest, one myocardial infarction, one transitory ischemic attack and one atrial flutter. Four of the incidents happened during or straight after a match, and one during training. Conclusions More than 1 in 100 players with negative screening results suffered severe cardiovascular incidents, included three sudden cardiac arrests, within 8 yrs of follow up. Mandatory preparticipation cardiovascular screening of professional soccer teams in Norway was not able to prevent this.
Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease
Authors: Mareike Franke, Bettina Baeßler, Jan Vechtel, Claudia Dafinger, Martin Höhne, Lori Borgal, Heike Göbel, Friederike Koerber, David Maintz, Thomas Benzing, Bernhard Schermer, Thorsten Persigehl
Journal: Kidney International (2017)
The use of fluorescent in situ hybridization for detection of the t(2;5)(p23;q35) translocation in anaplastic large-cell lymphoma
Authors: P.W.M. Johnson, J. Leek, K. Swinbank, B. Angus, P. Roberts, A.F. Markham, P.J. Selby, K.A. MacLennan
Journal: Annals of Oncology (1997)
Dendritic cell–targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation
Authors: Jocelyn T. Kim, Yarong Liu, Rajan P. Kulkarni, Kevin K. Lee, Bingbing Dai, Geoffrey Lovely, Yong Ouyang, Pin Wang, Lili Yang, David Baltimore
Journal: Science Immunology (2017)

Dendritic cell (DC) activation and antigen presentation are critical for efficient priming of T cell responses. Here, we study how lentiviral vectors (LVs) deliver antigen and activate DCs to generate T cell immunization in vivo. We report that antigenic proteins delivered in vector particles via pseudotransduction were sufficient to stimulate an antigen-specific immune response. The delivery of the viral genome encoding the antigen increased the magnitude of this response in vivo but was irrelevant in vitro. Activation of DCs by LVs was independent of MyD88, TRIF, and MAVS, ruling out an involvement of Toll-like receptor or RIG-I-like receptor signaling. Cellular DNA packaged in LV preparations induced DC activation by the host STING (stimulator of interferon genes) and cGAS (cyclic guanosine monophosphate-adenosine monophosphate synthase) pathway. Envelope-mediated viral fusion also activated DCs in a phosphoinositide 3-kinase-dependent but STING-independent process. Pseudotransduction, transduction, viral fusion, and delivery of cellular DNA collaborate to make the DC-targeted LV preparation an effective immunogen.
The Plasma Concentration of MUC5B Is Associated with Clinical Outcomes in Paraquat-poisoned Patients
Authors: Andrew A. Monte, Hao Sun, Anna Malin Rapp-Olsson, Fahim Mohamed, Indika Gawarammana, Nicholas A. Buckley, Christopher M. Evans, Ivana V. Yang, David A. Schwartz
Journal: American Journal of Respiratory and Critical Care Medicine (2017)
Revisiting the definition of estrogen receptor positivity in HER2-negative primary breast cancer
Authors: T. Fujii, T. Kogawa, W. Dong, A.A. Sahin, S. Moulder, J.K. Litton, D. Tripathy, T. Iwamoto, K.K. Hunt, L. Pusztai, B. Lim, Y. Shen, N.T. Ueno
Journal: Annals of Oncology (2017)
Interrogating the “unsequenceable” genomic trinucleotide repeat disorders by long-read sequencing
Authors: Qian Liu, Peng Zhang, Depeng Wang, Weihong Gu, Kai Wang
Journal: Genome Medicine (2017)

Microsatellite expansion, such as trinucleotide repeat expansion (TRE), is known to cause a number of genetic diseases. Sanger sequencing and next-generation short-read sequencing are unable to interrogate TRE reliably. We developed a novel algorithm called RepeatHMM to estimate repeat counts from long-read sequencing data. Evaluation on simulation data, real amplicon sequencing data on two repeat expansion disorders, and whole-genome sequencing data generated by PacBio and Oxford Nanopore technologies showed superior performance over competing approaches. We concluded that long-read sequencing coupled with RepeatHMM can estimate repeat counts on microsatellites and can interrogate the "unsequenceable" genomic trinucleotide repeat disorders.