AN EVALUATION OF THE EFFECT OF CHOLINE AND INOSITOL ON THE CLINICAL COURSE AND SERUM LIPIDS IN PATIENTS WITH ANGINA PECTORIS
Authors: R S JACKSON, C F WILKINSON, L MEYERS, M S BRUNO, M R BENJAMIN
Journal: Annals of Internal Medicine (1955)

Article1 March 1955AN EVALUATION OF THE EFFECT OF CHOLINE AND INOSITOL ON THE CLINICAL COURSE AND SERUM LIPIDS IN PATIENTS WITH ANGINA PECTORISRAYMOND S. JACKSON, M.D., CHAS. F. WILKINSON JR., M.D., F.A.C.P., LAWRENCE MEYERS, M.D., F.A.C.P., MICHAEL S. BRUNO, M.D., MARTIN R. BENJAMIN, M.D.RAYMOND S. JACKSON, M.D., CHAS. F. WILKINSON JR., M.D., F.A.C.P., LAWRENCE MEYERS, M.D., F.A.C.P., MICHAEL S. BRUNO, M.D., MARTIN R. BENJAMIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-3-583 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe question of whether lipotropic agents might have an effect upon atherosclerosis has been the basis for a number of studies in animals and in man. Clinical investigations have followed along two general lines. Attempts at direct therapeutic evaluation have depended upon the administration of a test substance to patients who have recovered from a myocardial infarction, comparing their course with that of an untreated group of coronary survivors. Strict comparability of methods of managing the basic disease and all concomitant diseases in both the treated and control groups is a necessary part of such a clinical test.The alternate,...Bibliography1. Davidson JD: Diet and lipotropic agents in arteriosclerosis, Am. J. Med. 11: 736, 1951. CrossrefMedlineGoogle Scholar2. ZollWesslerBlumgart PMSHL: Angina pectoris. A clinical and pathologic correlation, Am. J. Med. 11: 331, 1951. CrossrefMedlineGoogle Scholar3. GreinerGoldMcKeenTravellBakstRinzlerBenjaminWarshawBobbKwittModellRothendlerMesseloffKramer THKJHSHZHLJALNIWHHCRML: A method for the evaluation of the effects of drugs on cardiac pain in patients with angina of effort, Am. J. Med. 9: 143, 1950. CrossrefMedlineGoogle Scholar4. Sperry WM: The Schoenheimer-Sperry method for determination of cholesterol, Rev. Ed., 1945, Department of Biochemistry, Psychiatric Institute, New York. Google Scholar5. SimonsenWertmanWestoverMehl DGMLMJW: The determination of serum phosphate by the molybdivanadate method, J. Biol. Chem. 166: 747, 1946. CrossrefMedlineGoogle Scholar6. JacksonWilkinson RSCF: The ratio between phospholipid and the cholesterols in plasma as an index of human atherosclerosis, Ann. Int. Med. 37: 1162, 1952. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RAYMOND S. JACKSON, M.D.; CHAS. F. WILKINSONJR., M.D., F.A.C.P.; LAWRENCE MEYERS, M.D., F.A.C.P.; MICHAEL S. BRUNO, M.D.; MARTIN R. BENJAMIN, M.D.*Presented as a Morning Lecture at the Thirty-fifth Annual Session of the American College of Physicians, Chicago, Illinois, April 8, 1954.From the Department of Medicine, Post Graduate Medical School, New York University, and the Fourth Medical (N.Y.U.) Division, Bellevue Hospital, New York.Funds for this study were furnished in part by the Wyeth Laboratories and the Lillia Babbit Hyde Foundation.†Lillia Babbit Hyde Research Fellow.The Wychol and the placebo were furnished by the Wyeth Laboratories. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySerum Lipids in Patients with Senile Macular Degeneration* *From the Department of Medicine, West Virginia University School of Medicine, and the Section of Ophthalmology, Yale University School of Medicine. This study was supported (in part) by grant H-6714(Cl) from the National Heart Institute. This work was performed during tenure (M. J. A.) of an established investigatorship of the American Heart Association.Research in Russia on Vitamins and AtherosclerosisStudies on the Effect of a Low Lipid Diet and Lipotropic Agents in Cerebral AtherosclerosisEFFECTS OF LIPOTROPES AND SITOSTEROL ON THE LEVEL OF BLOOD LIPIDS AND THE CLINICAL COURSE OF ANGINA PECTORIS† 1 March 1955Volume 42, Issue 3 Page: 583-594 Keywords Angina Atherosclerosis Graduate medical education Hospital medicine Lipids Myocardial infarction Patients ePublished: 1 December 2008 Issue Published: 1 March 1955 PDF downloadLoading ...