tbuckley/cabot-search huggingface dataset:
A REMOTE LIPID MANAGEMENT PROGRAM IMPROVES APPROPRIATE STATIN USE AND CHOLESTEROL LEVELS ACROSS A WIDE POPULATION OF HIGH CARDIOVASCULAR RISK PATIENTS
Authors: Mark D. Benson, Marian McPartlin, Lina Matta, Michael Kraft, Kira C. Barclay, Tiffany V. Bui, Robert W. Blackburn, David Zelle, Ana Mercurio-Pinto, Thomas Gaziano, Calum MacRae, Benjamin Scirica, Jorge Plutzky
Journal: Journal of the American College of Cardiology (2018)
Islet Interleukin-1β Immunoreactivity Is an Early Feature of Cystic Fibrosis That May Contribute to β-Cell Failure
Authors: Rebecca L. Hull, Ronald L. Gibson, Sharon McNamara, Gail H. Deutsch, Corinne L. Fligner, Charles W. Frevert, Bonnie W. Ramsey, Srinath Sanda
Journal: Diabetes Care (2018)

OBJECTIVE Cystic fibrosis–related diabetes (CFRD) is a common complication of cystic fibrosis (CF), increasing patient morbidity and mortality. Poor understanding of CFRD pathogenesis limits the development of targeted therapies to treat and/or prevent the disease. The aim of this study was to evaluate islet pathology, specifically, inflammation, amyloid deposition, and endocrine cell composition in subjects with CF with diabetes and with CF without diabetes. RESEARCH DESIGN AND METHODS A retrospective analysis of archived pancreas tissue collected at autopsy was conducted using pancreas tissue from subjects with CF and diabetes (CFRD) (n = 18) and CF without diabetes (CF-no DM) (n = 17). Two cohorts of control non-CF subjects were identified, each matched to CFRD and CF-no DM subjects for age, sex, and BMI (non-CF older, n = 20, and non-CF younger, n = 20), respectively. Immunohistochemistry was performed to assess interleukin-1β (IL-1β) and islet hormone (insulin, glucagon, somatostatin, and pancreatic polypeptide) immunoreactivity; histochemistry was performed to quantify amyloid deposition. RESULTS Islet IL-1β immunoreactivity was substantially increased in both CFRD and CF-no DM subjects compared with non-CF subjects and was common in young subjects with CF (≤10 years of age). In contrast, islet amyloid deposition was increased only in CFRD subjects. We also observe abnormal islet hormone immunoreactivity, characterized by increased glucagon immunoreactivity, in CF-no DM and CFRD subjects compared with non-CF subjects. CONCLUSIONS These findings reveal novel molecular pathways and therapeutic targets underlying islet pathology in CF subjects and may be important in developing new approaches to treat CFRD.
Getting Research Published: an A to Z of publication strategy
Authors: Zain Khalpey
Journal: BMJ (2005)

Elizabeth Wager

Radcliffe, 2005, £21.95, 152 pages

ISBN 1 85775 687 8

Rating: ⋆⋆⋆/5



Over the past decade, a track record of accepted peer reviewed publications has been essential to getting established in a subspecialty in the medical profession. This book breaks through the traditional scholastic texts of “how to get published,” providing an invaluable blueprint in medical publication strategy. It is succinct, covers breadth and depth, and is aimed at physicians like myself; it left me inspired and prepared to write. Elizabeth …
IS THERE A CORRELATION BETWEEN AORTIC VALVE GRADIENT AND RECOVERED/IMPROVED LEFT VENTRICULAR EJECTION FRACTION AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT?
Authors: Ike Ifedili, Tamunoinemi Bob-Manuel, Mark Heckle, Rami Khouzam, Uzoma Ibebuogu
Journal: Journal of the American College of Cardiology (2018)
Responsible officers must be “sufficiently close” to doctors whose language skills they test, MPs say
Authors: Abi Rimmer
Journal: BMJ (2014)

The General Medical Council must ensure that responsible officers have a “sufficiently close” relationship with any doctors they test for English language competence, MPs have said.

From June this year the GMC will be able to test the English language competence of doctors from other European Union countries.1

In a report on their 2013 accountability hearing with the GMC, MPs on …
What is the difference between a LAT post and a LAS post?
Authors: Alan Watson
Journal: BMJ (2004)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone (www.bmjcareers.com/advicezone) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site.
UTILITY OF SHOCK INDEX IN PATIENTS PRESENTING WITH ACUTE HEART FAILURE: MULTICENTER MULTINATIONAL OBSERVATIONAL STUDY
Authors: Ayman El-Menyar, Kadhim Sulaiman, Wael A. Almahmeed, Nidal Asaad, Hajar Albinali, Rajvir Singh, Jassim Al Suwaidi
Journal: Journal of the American College of Cardiology (2018)
Integrating hepatitis B, hepatitis C and HIV screening into tuberculosis entry screening for migrants in the Netherlands, 2013 to 2015
Authors: Janneke P Bil, Peter AG Schrooders, Maria Prins, Peter M Kouw, Judith HE Klomp, Maarten Scholing, Lutje PHM Huijbregts, Gerard JB Sonder, Toos CHFM Waegemaekers, Henry JC de Vries, Wieneke Meijer, Freke R Zuure, Alma Tostmann
Journal: Eurosurveillance (2018)

We evaluated uptake and diagnostic outcomes of voluntary hepatitis B (HBV) and C virus (HCV) screening offered during routine tuberculosis entry screening to migrants in Gelderland and Amsterdam, the Netherlands, between 2013 and 2015. In Amsterdam, HIV screening was also offered. Overall, 54% (461/859) accepted screening. Prevalence of chronic HBV infection (HBsAg-positive) and HCV exposure (anti-HCV-positive) in Gelderland was 4.48% (9/201; 95% confidence interval (CI): 2.37–8.29) and 0.99% (2/203; 95% CI: 0.27–3.52), respectively, all infections were newly diagnosed. Prevalence of chronic HBV infection, HCV exposure and chronic HCV infection (HCV RNA-positive) in Amsterdam was 0.39% (1/256; 95% CI: 0.07–2.18), 1.17% (3/256; 95% CI: 0.40–3.39) and 0.39% (1/256; 95% CI: 0.07–2.18), respectively, with all chronic HBV/HCV infections previously diagnosed. No HIV infections were found. In univariate analyses, newly diagnosed chronic HBV infection was more likely in participants migrating for reasons other than work or study (4.35% vs 0.83%; odds ratio (OR) = 5.45; 95% CI: 1.12–26.60) and was less likely in participants in Amsterdam than Gelderland (0.00% vs 4.48%; OR = 0.04; 95% CI: 0.00–0.69). Regional differences in HBV prevalence might be explained by differences in the populations entering compulsory tuberculosis screening. Prescreening selection of migrants based on risk factors merits further exploration.
Neglected or abused children still receive little help, causing problems in adulthood
Authors: Adrian O’Dowd
Journal: BMJ (2018)

Children who experience neglect, abuse, or other adverse childhood events often receive little support and have poorer mental and physical health later in life, MPs have been told.

The serious long term impact of a lack of preventive action to help children who have had adverse childhood experiences was underlined by several witnesses appearing before the House of Commons science and technology committee on 20 February.

The committee is holding an inquiry into early years intervention, looking at the strength of evidence linking adverse childhood experiences to long term negative outcomes, the evidence base for related interventions, and whether evidence is used effectively in policy making.

MPs asked about the evidence base …
Location or origin? What is critical for macrophage propagation of lung fibrosis?
Authors: Xiaofeng Zhou, Bethany B. Moore
Journal: European Respiratory Journal (2018)

Radiation-induced pulmonary fibrosis develops following radiotherapy for chest wall and lung malignancies, affects quality of life and is often lethal [1]. Similarly, idiopathic forms of lung fibrosis show progressive accumulation of extracellular matrix leading to respiratory insufficiency [2]. Currently, treatments for either radiation-induced or idiopathic forms of pulmonary fibrosis are limited and largely ineffective. Immunosuppressive therapies may be harmful in idiopathic pulmonary fibrosis [3], and are used in radiation-induced fibrosis with limited effect [4]. Growing evidence suggests macrophages are critical regulators of lung fibrosis [5]; however, the subtypes involved and mechanisms responsible are just beginning to be understood. Pulmonary macrophages are critical for innate immunity and response to pathogens or injury, but also play important roles in resolution of inflammation and wound healing. These versatile immune cells are composed of heterogeneous populations with different origins that reside in unique locations within the lung. Recruited lung macrophages are key in driving lung fibrosis, but the location varies with different forms of fibrosis <http://ow.ly/kTIq30ixgpR>
THE GAP IN EFFICACY AND SAFETY OF UNFRACTIONATED HEPARIN AND BIVALIRUDIN IS CLOSING WITH CONTEMPORARY PCI STRATEGIES FOR MYOCARDIAL INFARCTION: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Sukhchain Singh, Varun Kumar, Daniela Kovacs, Sandeep Khosla, Rohit Arora
Journal: Journal of the American College of Cardiology (2018)
The unmet medical need of pulmonary hypertension in idiopathic pulmonary fibrosis
Authors: Vincent Cottin, Laura C. Price, Claudia Valenzuela
Journal: European Respiratory Journal (2018)

Pulmonary hypertension (PH) is defined as a mean pulmonary artery pressure (PAP) greater or equal to 25 mmHg, and is a frequent complication in patients with idiopathic pulmonary fibrosis (IPF) [1], especially at an advanced stage of the disease, or when emphysema is associated, as in the syndrome of combined pulmonary fibrosis and emphysema [2]. At diagnosis, 8% to 15% of patients with IPF may already have precapillary PH [3], a proportion which rises up to 30% to 50% of patients at the time of evaluation for lung transplantation [4–7]. The frequency of PH further increases with comorbidities such as obstructive sleep apnoea, thromboembolism or cardiac diastolic dysfunction [8]. PH, when present, is associated with dramatic worsening of shortness of breath, greater oxygen requirements, more severe limitation to exercise capacity and increased mortality [4, 8–10]. PH in IPF (group 3 of the World Health Organization pulmonary hypertension classification [11]) is usually of mild or moderate haemodynamic severity, although 2–10% of patients have a mean PAP greater than 35–40 mmHg [3–5]. Prospective studies are needed for noninvasive detection of pulmonary hypertension in patients with IPF <http://ow.ly/Yydw30hoGqk>
GPs increasingly seek advice on estranged parents’ access to children’s medical records
Authors: Tom Moberly
Journal: BMJ (2013)

GPs who face requests from estranged parents for access to their children’s medical records are increasingly seeking professional advice, the Medical Protection Society (MPS) has said.

The MPS said that it was receiving more telephone calls seeking advice on requests for GPs to disclose information in children’s health records to the parents of children who are patients. The society received …
Abstract P2-02-17: Circulating tumor DNA analysis with ultra-high sensitivity sequencing in metastatic breast cancer
Authors: I Garcia-Murillas, P Proszek, C Fribbens, L Yuan, H Bye, M Hubank, J Jiang, S Yuang, J Palma, S Johnston, A Ring, N Turner
Journal: Cancer Research (2018)

Abstract Introduction. Circulating tumor DNA analysis has the potential to transform the clinical management of patients with breast cancer. We assessed the accuracy of ultra-high sensitivity ctDNA testing in patients with advanced breast cancer. Methods. From a prospective tissue collection study, we identified 25 patients with a contemporaneous metastatic tissue biopsy and plasma for ctDNA testing. Tumour DNA from the metastatic tissue biopsy was sequenced with a validated clinical hybrid capture panel, while plasma cell free DNA was sequenced with AVENIO ctDNA technology – a molecular barcoded duplex sequencing based on CAPPseq technology. Sample collection is on-going and results from the full concordance series will be presented at the conference. Results. Circulating tumour DNA was detectable in 87% (20/23) of patients, with at least one variant from tissue sequencing identified in plasma. There was overall high agreement between tissue and plasma sequencing. The sensitivity of plasma testing for variants identified in tumour, positive percent agreement, was 75% (24/32). Plasma testing revealed a diversity of sub-clonal mutations including polyclonal ESR1, polyclonal FGFR2 and FGFR3 mutations, rare KRAS mutations, and TSC1 and MSH2 inactivating mutations. Conclusions. Circulating tumour DNA testing with molecular barcoded duplex sequencing offers high sensitivity for tumour variant detection. The extent of sub-clonal resistance mutations identified emphasises the genetic diversity of advanced breast cancer. Citation Format: Garcia-Murillas I, Proszek P, Fribbens C, Yuan L, Bye H, Hubank M, Jiang J, Yuang S, Palma J, Johnston S, Ring A, Turner N. Circulating tumor DNA analysis with ultra-high sensitivity sequencing in metastatic breast cancer [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P2-02-17.
First victim, later aggressor: How the intestinal microbiota drives the pro-inflammatory effects of dietary emulsifiers?
Authors: Emilie Viennois, Benoit Chassaing
Journal: Gut Microbes (2018)

The intestinal tract is inhabited by a large and diverse community of bacteria, collectively referred to as the gut microbiota. Composed of 500–1000 distinct species, the intestinal microbiota plays an important role in immunity and metabolism. However, alterations in its composition are associated with a variety of inflammatory diseases including obesity, diabetes, and inflammatory bowel disease (IBD). Among many other factors, our diet impacts microbiota composition and function, in either beneficial or detrimental ways. In this addendum, we will discuss our recent findings on how dietary emulsifying agents can directly and detrimentally impact the microbiota, leading to inflammatory diseases and cancer.
Hypercholesterolemia induces T cell expansion in humanized immune mice
Authors: Jonathan D. Proto, Amanda C. Doran, Manikandan Subramanian, Hui Wang, Mingyou Zhang, Erdi Sozen, Christina C. Rymond, George Kuriakose, Vivette D’Agati, Robert Winchester, Megan Sykes, Yong-Guang Yang, Ira Tabas
Journal: Journal of Clinical Investigation (2018)

Emerging data suggest that hypercholesterolemia has stimulatory effects on adaptive immunity and that these effects can promote atherosclerosis and perhaps other inflammatory diseases. However, research in this area has relied primarily on inbred strains of mice whose adaptive immune system can differ substantially from that of humans. Moreover, the genetically induced hypercholesterolemia in these models typically results in plasma cholesterol levels that are much higher than those in most humans. To overcome these obstacles, we studied human immune system-reconstituted mice (hu-mice) rendered hypercholesterolemic by treatment with adeno-associated virus 8-proprotein convertase subtilisin/kexin type 9 (AAV8-PCSK9) and a high-fat/high-cholesterol Western-type diet (WD). These mice had a high percentage of human T cells and moderate hypercholesterolemia. Compared with hu-mice that had lower plasma cholesterol, the PCSK9-WD mice developed a T cell-mediated inflammatory response in the lung and liver. Human CD4+ and CD8+ T cells bearing an effector memory phenotype were significantly elevated in the blood, spleen, and lungs of PCSK9-WD hu-mice, whereas splenic and circulating regulatory T cells were reduced. These data show that moderately high plasma cholesterol can disrupt human T cell homeostasis in vivo. This process may not only exacerbate atherosclerosis, but also contribute to T cell-mediated inflammatory diseases in the hypercholesterolemia setting.
OUTCOMES OF JUNCTIONAL ECTOPIC TACHYCARDIA ABLATION IN ADULT POPULATION: A MULTICENTER EXPERIENCE
Authors: Tawseef Dar, Bharath Yarlagadda, Mohit Turagam, Vaishnavi Veerapaneni, Valay Parikh, Madhu Reddy, Donita Atkins, Sudharani Bommana, Luigi Di Biase, Vijay Swarup, Rakesh Gopinathannair, Andrea Natale, Seth Sheldon, Dhanunjaya R. Lakkireddy
Journal: Journal of the American College of Cardiology (2018)
In vitro and in vivo delivery of siRNA via VIPER polymer system to lung cells
Authors: Daniel P. Feldmann, Yilong Cheng, Rima Kandil, Yuran Xie, Mariam Mohammadi, Hartmann Harz, Akhil Sharma, David J. Peeler, Anna Moszczynska, Heinrich Leonhardt, Suzie H. Pun, Olivia M. Merkel
Journal: Journal of Controlled Release (2018)
EFFECTS OF ADVANCED HEART FAILURE TREATMENT ON MORTALITY IN PATIENTS WITH A SYSTEMIC RIGHT VENTRICLE
Authors: Mikael G. Dellborg, Kristofer Skoglund, Joel Heimdahl, Ulf Thilen, Bengt Johansson, Christina Christersson, Eva Mattsson, Peter Eriksson
Journal: Journal of the American College of Cardiology (2018)
Cost-effectiveness of denosumab (D) versus zoledronic acid (Z) for skeletal-related event (SRE) reduction in bone-metastatic prostate cancer (mPC) in the United Kingdom.
Authors: Marc Botteman, John A. Carter, Peter Fishman, David Chandiwana, Manjinder Bains, Sonya J. Snedecor
Journal: Journal of Clinical Oncology (2012)

e15189 Background: D reduced SREs vs Z in a phase III trial, but no significant differences in overall survival, disease progression, or serious adverse events were reported. The cost-effectiveness of D vs Z in mPC was assessed from a UK payer perspective. Methods: A literature-based Markov model estimated quality-adjusted life-years (QALYs), number and costs of SREs, and drug/administration costs for mPC pts receiving D or Z for 27 mo (trial timeframe) and 60 mo (extended lifetime analysis). Current list prices/injection (£309.86 for D; £174.14 for Z) were used in the base case. As the model’s analytical horizon starts June 2012 and extends beyond generic Z availability in May 2013, a generic Z price (53% &lt; list price, per data for other now-generic bisphosphonates) was used beyond May 2013 in scenario analysis. In other analyses, discounted prices (–30%) were used for both D and Z to assess the effect of price reductions on cost/QALY. Clinical inputs were selected to reproduce trial outcomes. QALYs were estimated by assigning utility weights to time spent in health states (no SRE; SRE; post-SRE; death). SRE costs were £250 to ≥ £6,000/event. Results: Although D may result in fewer SREs, higher QALYs, and lower SRE-related costs (Table), higher acquisition cost of D results in substantially higher costs and may be cost-ineffective in every pricing scenario. Similar results were found for the 27-mo analysis. Conclusions: The incremental cost/QALY gained with D vs Z ranged from £50,000 to £215,000 (&gt; traditional £30,000 threshold), thus raising important questions about D’s value in mPC. [Table: see text]
Caval Valve Implantation for Treatment of Severe Tricuspid Regurgitation
Authors: Alexander Lauten, Henryk Dreger, Joachim Schofer, Eberhard Grube, Frederik Beckhoff, Philipp Jakob, Jan-Malte Sinning, Karl Stangl, Hans R. Figulla, Michael Laule
Journal: Journal of the American College of Cardiology (2018)
Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice
Authors: Shenhai Gong, Tian Lan, Liyan Zeng, Haihua Luo, Xiaoyu Yang, Na Li, Xiaojiao Chen, Zhanguo Liu, Rui Li, Sanda Win, Shuwen Liu, Hongwei Zhou, Bernd Schnabl, Yong Jiang, Neil Kaplowitz, Peng Chen
Journal: Journal of Hepatology (2018)
Diploma of the Royal College of Ophthalmologists, London (DRCOphth)
Authors: Jayasis Bandyopadhyay
Journal: BMJ (2005)

Any medically qualified personnel with a General Medical Council approved degree. You must also have one year's full time ophthalmology experience to be eligible for the exam.

In November 2002, during my first year as a locum senior house officer in ophthalmology. I had more than two years of ophthalmology experience in India.

Because I wanted to get the feel of an objective structured clinical examination (OSCE) exam before going in for the Part 2 exam. Moreover, a …
Appearance of an Unusual Cerebellar Lesion
Authors: Magda Zanelli, Maria Cecilia Mengoli, Elisabetta Froio
Journal: JAMA Neurology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
More paediatric consultants are needed in community to ease service pressure, college says
Authors: Marika Davies
Journal: BMJ (2015)

More paediatric consultants are needed in the community to ease pressure on services, the Royal College of Paediatrics and Child Health has said.

The college’s 2013 workforce census report provided a snapshot of how the UK’s paediatric services are structured.1 The report showed that more needed to be done to take pressure off acute services, to deliver more care outside hospitals, and to ensure that more child health experts work in community settings.

Hilary Cass, the college’s president, said, “We …
HYPERLIPIDEMIA PARADOX: HYPERLIPIDEMIA LOWERS THE RISK OF DEATH AND ATTENUATES THE MORTALITY RISK OF OTHER COMORBID CONDITIONS AFTER HOSPITALIZATION FOR ACUTE MYOCARDIAL INFARCTION AND HEART FAILURE
Authors: Mohammed Yousufuddin, Jessica Shultz, Lawrence Keenan, Taylor Doyle, Ahmmad Eimad, Tammy Olson, Paul Takahashi, M. Hassan Murad
Journal: Journal of the American College of Cardiology (2018)
Comment on Santema et al. Hyperbaric Oxygen Therapy in the Treatment of Ischemic Lower-Extremity Ulcers in Patients With Diabetes: Results of the DAMO2CLES Multicenter Randomized Clinical Trial. Diabetes Care 2018;41:112–119
Authors: Enoch Huang
Journal: Diabetes Care (2018)

The DAMO2CLES [Does Applying More Oxygen (O2) Cure Lower Extremity Sores?] study (1) is the only prospective multicenter trial evaluating the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of ischemic diabetic foot ulcers (DFUs). By involving 10 hyperbaric facilities across the Netherlands and Belgium, this protocol captures a cross-section of the standard care (SC) in the region with regard to ischemic DFUs but falls victim to variable clinical practice patterns. The authors state that there was adherence to DFU best practice management (2) but did not state how different sites used transcutaneous oxygen monitoring, cellular tissue products, or total contact casting. Recruitment was difficult, which …
Long-Acting β-Agonist/Inhaled Corticosteroid in Patients with Chronic Obstructive Pulmonary Disease with Cardiovascular Disease or Risk: A Factorial Analysis of the SUMMIT Clinical Trial
Authors: Bartolome Celli, Julie A. Anderson, Robert Brook, Peter Calverley, Courtney Crim, Andrew P. Holmes, Fernando J. Martinez, David E. Newby, Julie Yates, Jørgen Vestbo
Journal: American Journal of Respiratory and Critical Care Medicine (2018)