tbuckley/cabot-search huggingface dataset:
Abstract 10261: Musculoskeletal Pain in Cardiac Sonographers: A Multisite Case Control Study
Authors: Nicholas M Orme, Jeffrey B Geske, Sorin V Pislaru, John W Askew, Ryan J Lennon, Bradley R Lewis, Charanjit S Rihal, Mandeep Singh, Patricia A Pellikka
Journal: Circulation (2015)

Background: Transthoracic echocardiography is the mainstay of cardiac imaging and is highly dependent upon cardiac sonographers for whom image acquisition can be physically demanding and associated with musculoskeletal pain. Prior studies are limited by the absence of adequate control groups and a lack of adjustment for potential confounders. Objectives: The purpose of this study was to determine the prevalence and impact of work-related musculoskeletal pain in cardiac sonographers as compared to a large control group of non-invasive healthcare professionals with similar demographics. Methods: An electronic survey was administered to Mayo Clinic employees identified by human resources at six major patient care facilities in four different states. Results: There were 2682 employees within the departments of cardiology and radiology who were contacted and 1532 (57%) completed the survey. After exclusion of those who wear protective lead aprons, 517 employees comprised the control group and 66 cardiac sonographers made up the study group. Cardiac sonographers and the control group were similar in age, sex, BMI, length of employment and history of prior musculoskeletal pain. Cardiac sonographers reported work-related musculoskeletal pain more frequently than the control group (88% vs 40%; p&lt;0.001). This association persisted after multivariable adjustment for age, sex, body mass index, length of current employment and history of pre-existing musculoskeletal pain (OR 11.6; (95% CI 5.32, 25.5); p&lt;0.001). Cardiac sonographers were more likely to seek medical care for their work-related pain (55% vs 21%; p&lt;0.001) and to have missed work due to pain (35% vs 12%, p&lt;0.001). Conclusions: In this multi-site case control study, cardiac sonographers experienced significantly more work-related pain and missed more work due to pain than a large control group of non-invasive healthcare professionals with similar demographics.
Abstract P357: Ideal Cardiovascular Health Criteria are Inversely Related to Cardiovascular Disease and All-Cause Mortality in a Sample of Canadian Adults
Authors: Deirdre M Harrington, Amanda E Staiano, Bruce A Reeder, Susan J Elliott, Peter T Katzmarzyk
Journal: Circulation (2013)

Background: Ideal Cardiovascular (CV) Health is an AHA 2020 Impact Goal and consists of 7 health metrics which the public are encouraged to achieve. It is a relatively new definition of health so r...
Heterogeneous Virologic Response Rates to Interferon-Based Therapy in Patients with Chronic Hepatitis C: Who Responds Less Well?
Authors: Stefan Zeuzem
Journal: Annals of Internal Medicine (2004)

The introduction of new agents and regimens for the treatment of chronic hepatitis C, such as pegylated interferons and combination therapy with ribavirin, has resulted in substantial improvements in sustained virologic response rates. However, treatment remains a challenge, particularly for certain patient populations, because several virus-related and patient-related factors are associated with a lower virologic response to therapy. Hepatitis C virus genotype 1 and a high baseline viral load are the major viral factors associated with lower response. Patient-related factors include previous relapse or nonresponse to treatment, the presence of cirrhosis, African-American ethnicity, older age, contraindications to treatment, and obesity. This article reviews the data on interferon-based therapies among patients with lower chances for sustained virologic response and discusses the potential of the new pegylated interferons.
An insertion mutation in <i>HOXC13</i> underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction
Authors: A. Humbatova, R. Maroofian, M.-T. Romano, A. Tafazzoli, M. Behnam, N. Dilaver, N. Nouri, M. Salehi, S. Wolf, J. Frank, P. Kokordelis, R.C. Betz
Journal: British Journal of Dermatology (2017)
Aberrations in structure/distribution of microfilaments in Nickel/MCA transformed 10T1/2 mouse embryo cell lines bearing amplification of ECT-2 proto-oncogene
Authors: Aruni DeSilva, Hong Lee, Joseph Landolph
Journal: Cancer Research (2008)

2226   Inhalation of Ni refinery dusts from Ni-containing sulfidic ores combined with cigarette smoking induces respiratory cancer in humans. Nickel subsulfide (Ni 3 S 2)  and green NiO induce respiratory cancer by the inhalation route in rats. We previously showed Ni 3 S 2 , green NiO, and black NiO, were phagocytosed into, and induced morphological, A. I., and neoplastic transformation in, C3H/10T1/2 mouse embryo cells, and 130 genes were differentially expressed between non-transformed and one MCA/four Ni-transformed 10T1/2 cell lines. Ni/MCA-transformed cell lines displayed a) ect-2 gene amplification and higher steady-state levels of ect-2 (rho GDP/GTP exchange factor gene) mRNA/protein; higher steady-state levels of b) calnexin mRNA/protein and c) Wdr 1 (stress-inducible gene) mRNA; and d) decreased levels of mRNAs from DRIP/TRAP-80 and β-2-centaurin genes. We hypothesized that in Ni-transformed cell lines, amplification of the ect-2 gene and higher steady-state levels of rho-GTP, would alter the structure and distribution of microfilaments, which would lead to aberrations in expression of 16 genes and contribute to cell transformation. To test this hypothesis, we studied the structure and distribution of actin microfilaments in non-transformed 10T1/2 cells and in Ni/MCA transformed 10T1/2 cell lines. We stained cells with a fluorescent derivative of phalloidin, a fungal toxin that binds to microfilaments of mammalian cells, then examined cells by fluorescent confocal microscopy. In non-transformed 10T1/2 cells, actin was arranged in long, thin fibers that stretched from the membranes to the nuclei and were distributed homogeneously throughout the cell. In contrast, in one MCA-transformed cell line, large areas of cells were devoid of microfilaments. In three cell lines transformed by crystalline NiS (NiS3A, NiS3B, and NiS7A) and in one transformed by green (high temperature) NiO (NiO2C3), the microfilaments were aggregated into clumps in some areas. Other areas of the cells were devoid of microfilaments. Dis-aggregation and/or clumping of microfilaments in transformed cell lines changed the shape of the transformed cells, rounding them, and altering their contact with the extra-cellular matrix. This would then lead to differential expression of 16 genes in the transformed cell lines, over-expression of eight genes and under-expression of eight genes, contributing to induction/maintenance of the transformed state. Supported by grant R01 ES03341/NIEHS (P. I., JRL), and Training Grants 5T32 CA09320/NCI. (P.I., JRL) and 5T32 AI078078/NIAID.
Domestic fungal exposure and asthma morbidity among asthmatic children living in NYC homes damaged by Hurricane Sandy
Authors: Maureen Little, Luis M. Acosta, Christopher D'Andrea, Adnan Divjan, Karen C. Dannemiller, Edward A. Sobek, Angela R. Lemons, Brett J. Green, Matthew Perzanowski
Journal: Journal of Allergy and Clinical Immunology (2018)
A phase I/II trial of vorinostat (SAHA) in combination with rituximab‐CHOP in patients with newly diagnosed advanced stage diffuse large B‐cell lymphoma (DLBCL): SWOG S0806
Authors: Daniel O. Persky, Hongli Li, Lisa M. Rimsza, Paul M. Barr, Leslie L. Popplewell, Charles L. Bane, Ann Von Gehr, Michael LeBlanc, Richard I. Fisher, Sonali M. Smith, Jonathan W. Friedberg
Journal: American Journal of Hematology (2017)

Loss of major histocompatibility Class II expression (MHCII) in diffuse large B-cell lymphoma (DLBCL) correlates with decreased survival. MHCII transcription is in part regulated by histone acetylation. We tested the hypothesis that combination of histone deacetylase inhibitor (HDACI) with standard chemotherapy would improve outcomes in DLBCL in part through increased MHCII expression. S0806 was a single arm phase I/II trial of vorinostat given at 400 mg po daily on days 1-9 (subsequently amended to days 1-5 due to toxicity), combined with R-CHOP given on day 3 of a 21-day cycle for 8 cycles, with primary phase II endpoint of 2-year progression free survival (PFS). With 72 evaluable patients, at median follow up of 3 years, 2-year PFS estimate was 73%, and OS estimate was 86%. Considering that the regimen fell short of predefined efficacy improvement and was associated with high rates of febrile neutropenia (38%) and sepsis (19%), it cannot be recommended for general use. Consistent with our hypothesis, patients with low MCHII expression on S0806 had numerically superior outcomes compared to those from trial S0433 which did not use an HDACI, but the difference was not statistically significant. Current studies are focused on finding biomarkers of response to HDACI.
Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial
Journal: BMJ (2017)

<b>Objective</b>&nbsp;To determine whether being upright in the second stage of labour in nulliparous women with a low dose epidural increases the chance of spontaneous vaginal birth compared with lying down. <b>Design</b>&nbsp;Multicentre pragmatic individually randomised controlled trial. <b>Setting</b>&nbsp;41 UK hospital labour wards. <b>Participants</b>&nbsp;3093 nulliparous women aged 16 or older, at term with a singleton cephalic presentation and in the second stage of labour with epidural analgesia. <b>Interventions</b>&nbsp;Women were allocated to an upright or lying down position, using a secure web based randomisation service, stratified by centre, with no masking of participants or clinicians to the trial interventions. <b>Main outcome measures</b>&nbsp;The primary outcome was spontaneous vaginal birth. Women were analysed in the groups into which they were randomly allocated, regardless of position recorded at any time during the second stage of labour (excluding women with no valid consent, who withdrew, or who did not reach second stage before delivery). Secondary outcomes included mode of birth, perineal trauma, infant Apgar score &lt;4 at five minutes, admission to a neonatal unit, and longer term included maternal physical and psychological health, incontinence, and infant gross developmental delay. <b>Results</b>&nbsp;Between 4 October 2010 and 31 January 2014, 3236 women were randomised and 3093 (95.6%) included in the primary analysis (1556 in the upright group and 1537 in the lying down group). Significantly fewer spontaneous vaginal births occurred in women in the upright group: 35.2% (548/1556) compared with 41.1% (632/1537) in the lying down group (adjusted risk ratio 0.86, 95% confidence interval 0.78 to 0.94). This represents a 5.9% absolute increase in the chance of spontaneous vaginal birth in the lying down group (number needed to treat 17, 95% confidence interval 11 to 40). No evidence of differences was found for most of the secondary maternal, neonatal, or longer term outcomes including instrumental vaginal delivery (adjusted risk ratio 1.08, 99% confidence interval 0.99 to 1.18), obstetric anal sphincter injury (1.27, 0.88 to 1.84), infant Apgar score &lt;4 at five minutes (0.66, 0.06 to 6.88), and maternal faecal incontinence at one year (1.18, 0.61 to 2.28). <b>Conclusions</b>&nbsp;Evidence shows that lying down in the second stage of labour results in more spontaneous vaginal births in nulliparous women with epidural analgesia, with no apparent disadvantages in relation to short or longer term outcomes for mother or baby. <b>Trial registration</b>&nbsp;Current Controlled Trials ISRCTN35706297.
Dose-escalated intensity modulated radiotherapy (IMRT) and increased radiation doses to subventricular zones (SVZ) in treatment outcomes of patients with glioblastoma multiforme (GBM).
Authors: Melvin Chua, Grace Kusumawidjaja, Patricia Gan, Daniel HY Tan, Eu Tiong Chua, Chee Kian Tham, Fuh Yong Wong
Journal: Journal of Clinical Oncology (2014)

e13031 Background: Despite the landmark improvement of survival outcomes with the advent of temozolomide (TMZ) and radiotherapy (RT) in patients with GBM, primary tumor control remains suboptimal, with recurrences mostly occurring within the high dose irradiated region (60 Gy). This study investigates if dose escalated RT (70 Gy), delivered using IMRT, improves tumor control and survival outcomes in patients with GBM. Methods: Patients with surgically resected or biopsy proven GBM were eligible for dose escalated IMRT. A simultaneous boost technique was used to deliver 70 Gy and 60 Gy in 30 fractions over 6 weeks to the clinical target volumes (CTV70, CTV60). CTV70 was the tumor bed ± contrast enhancing region with 0.5 cm margin, while CTV60 was defined similarly with a wider margin of 2.0 cm. A further 0.5 cm expansion of both CTVs derived the final treated volumes. Patients received concurrent and adjuvant TMZ with IMRT. Results: 49 patients were analysed with a median follow up of 60 months. Median PFS and OS were 7.9 (95% CI = 5.0-10.9) and 15.4 (11.9-19.0) months, respectively. Primary tumor relapse was definitive in 32 patients. Of these, 68.8% (22/32) were in-field, 28.1% (9/32) marginal, 3.1% (1/32) distal, defined as >80%, 20-80%, and <20% of recurrence volume within the 70 Gy isodose, respectively. All recurrences were in-field relative to the 60 Gy isodose. Radiation dose to the SVZ was quantified. Mean doses (Gy) were 60.6 (range 33.4-69.8), 39.5 (19.4-61.2), 49.1 (28.3-64.3) to the ipsilateral, contralateral, and composite SVZ, respectively. There was no positive association between SVZ doses and PFS (HR = 1.05, ipsilateral, 95% CI = 0.88-1.24; 1.143, contralateral, 0.94-1.39; 0.80, composite, 0.57-1.12). No grade 3 toxicity was reported for the cohort. Conclusions: Dose escalated hypofractionated IMRT with TMZ did not seemingly improve patient survival. Despite dose escalation, GBM remains radio-resistant with the majority of tumors recurring within the 70 Gy treated volume. Although dose escalated IMRT resulted in increased SVZ doses (>40 Gy), this was not associated with a prolonged PFS, contrary to published reports.
Cancer patients admitted to intensive care unit- A six year experience of a single South American center.
Authors: Marcelo Rocha De Sousa Cruz, Rodrigo Rovere, Giuliano Santos Borges, Maria Eduarda Pires de Souza, Adma Silva de Lima, Alysson Rafael Fabris, Danielle Louise Cidral, Yasmine Rodrigues Chamse Ddine, Sara Fernanda Hilgert
Journal: Journal of Clinical Oncology (2015)

e12617 Background: Literature about critically ill cancer patients admitted to an intensive care unit is scarce. The decision to recommend an intensive care unit (ICU) admission is complex (1) and usually involves many subjective factors, making it an intricate issue for both medical oncologists and intensive care physicians. is clearly shifting and newer admission parameters should be established. We have performed a retrospective search of all the patients with an diagnosed malignancy admitted to our ICU from 2008 to 2014 in order to establish factors associated with outcomes. Methods: A retrospective search has been performed in our intensive care unit. Every single admitted adult patient was screened and patients diagnosed either previously or during inpatient care. To compare the frequencies within a distribution, we used the Chi square adherence test. To compare tumour types we have used the Student t test for independent samples. To correlate the length of stay in hospital at the age of patients was used linear correlation Person. If P value was < 0.05 then a significant correlation was established. Results: We surveyed a total of 165 patients of which 79 (47.9%) were female and 86 (52.1 %) were male, and second the Chi square grip both sexes showed similar amounts (P = 0.5858). According to the Student's t test for independent samples held in the sub table 2 the sample indicates no significant differences between men and women to the length of time and the age of patients, since in both cases the P-value > 0.05. Conclusions: As previously exposed, it becomes more and more clear that the natural history of cancer patients is swiftly changing to better outcomes during the last decades, given best supportive care (7) and life prolonging drugs newly available. Given the high heterogeneity of patients, it is a difficult task to design definitive guidelines about cancer affected individuals admittance in an ICU. In spite of that, clearly old clinical standards should not be used nowadays. We believe that no single criterium such as age or stage of the disease should be taken as absolute. Instead, decisions shoud be based on clinical judgement on every individual case.
Influenza A(H3N2) virus variants and patient characteristics during a summer influenza epidemic in Taiwan, 2017
Authors: Tsung-Pei Tsou, Chia-Ping Su, Wan-Ting Huang, Ji-Rong Yang, Ming-Tsan Liu
Journal: Eurosurveillance (2017)

We report a summer influenza epidemic caused by co-circulation of multiple influenza A(H3N2) variants in clade 3C.2a. Compared with other clades, a putative clade 3C.2a.3a was more commonly isolated from severely ill patients; 3C.2a.4 was more commonly isolated in outbreak cases. Time from vaccination to illness onset was significantly shorter in severely ill patients infected with clade 3C.2a.3; characteristics and outcomes of patients infected with different clades were similar. No resistance to antiviral medications was found.
Periconceptional Folate Supplementation and the Risk of Autism Following Antiepileptic Drug Exposure
Authors: Kimford J. Meador
Journal: JAMA Neurology (2017)

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18F-FDG PET/CT in Diagnostic and Prognostic Evaluation of Patients With Suspected Recurrence of Chondrosarcoma
Authors: Shelvin Kumar Vadi, Bhagwant Rai Mittal, Arun Kumar Reddy Gorla, Ashwani Sood, Rajender Kumar Basher, Apurva Sood, Nandita Kakkar, Ramesh K. Sen
Journal: Clinical Nuclear Medicine (2017)

The aim of the study was to analyze the diagnostic and prognostic utility of F-FDG PET/CT to predict the disease-specific survival (DSS) with FDG uptake and tumor grade in recurrent chondrosarcoma.Retrospective analysis of FDG PET/CT findings in 31 previously treated patients (46 studies) with mean follow-up period of 40.7 ± 23.9 months (range, 3-77 months) from the date of first PET/CT study was done. Kaplan-Meier DSS analysis was made with respect to tumor grade, FDG uptake at the recurrent primary sites, and a combination of grade and FDG uptake as parameters.Recurrence (local and distant) was shown in 28 (60.8%) of 46 FDG PET/CT studies with sensitivity and specificity of 88.9% and 78.9%, respectively. The median SUVmax at the recurrent primary sites differed significantly (P = 0.008) among 3 tumor grade groups, with higher median SUVmax in higher grades. There was significant difference in median SUVmax among different grade groups except between grade II and grade III. Recurrent primary site SUVmax cutoff at 6.15 derived from the receiver operating characteristic curve yielded significant difference (P < 0.001) in mean DSS time. Significant difference in survival was noted between 3 different tumor grade groups (P = 0.016). The combination of SUVmax and grade improved the survival prediction than with grade alone.In recurrent chondrosarcoma, the recurrent primary site FDG uptake and grade were found to be reliable prognostic factors with respect to DSS. PET/CT in recurrence setting has the potential to predict tumor grade and survival and may assist in clinical management.
Abstract 18181: Intravascular Coagulation During Prolonged Cardiac Arrest
Authors: Ryan A Coute, Nicole L Werner, Alvaro Rojas-Pena, Stephanie Rakestraw, Fares Alghanem, M. Hakam Tiba, Robert H Bartlett, Robert W Neumar
Journal: Circulation (2016)

Background: A potential barrier to the success of extracorporeal cardiopulmonary resuscitation (ECPR) after prolonged cardiac arrest is the “no-reflow phenomenon”, and intravascular coagulation is ...
Aortic stiffness is associated with aortic and coronary calcification in older adults
Authors: Rachel H. Mackey, Kim Sutton-Tyrrell, Lewis H. Kuller, Barbara L. Naydeck, Anne B. Newman
Journal: Circulation (2001)

P23     Aortic stiffness increases with age and blood pressure, even  when the population prevalence of atherosclerosis is low. The extent to  which atherosclerosis may exacerbate the aortic stiffening of aging  remains unclear. Aortic stiffness was measured by carotid to femoral  pulse wave velocity (PWV) and atherosclerosis by coronary artery  calcification score (CCS) and aortic calcification score (ACS) by  electron beam tomography in 484 participants (42% men, 23% black)  aged 70-96 years (mean=79.4) from the Pittsburgh site of the  Cardiovascular Health Study. The distributions of PWV (898, 851,  366-2183 cm/sec) (mean, median, range), CCS (676, 327, 0-4954) and ACS  (5183, 3040, 0-57,950) were log-transformed when used as continuous  variables. Median PWV and ACS were not different by gender but CCS was  higher for men than women (median 637 vs. 187, p