tbuckley/cabot-search huggingface dataset:
Annals Story Slam - Death of a Patient
Authors: Amy L. Davis
Journal: Annals of Internal Medicine (2018)

Web Exclusives17 July 2018Annals Story Slam - Death of a PatientFREEAmy L. Davis, DO, MSAmy L. Davis, DO, MSDrexel University School of Medicine, Philadelphia, Pennsylvania (A.L.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W18-0017 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Death of a Patient "Death of a Patient," by Amy L. Davis (Duration 6:48)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Drexel University School of Medicine, Philadelphia, Pennsylvania (A.L.D.)Corresponding Author: Amy L. Davis, DO, MS; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 July 2018Volume 169, Issue 2Page: SS1 ePublished: 17 July 2018 Issue Published: 17 July 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.Loading ...
Time to blood culture positivity: An independent predictor of infective endocarditis and mortality in patients with Staphylococcus aureus bacteraemia
Authors: S. Siméon, V. Le Moing, S. Tubiana, X. Duval, D. Fournier, J.-P. Lavigne, M.-L. Erpelding, C.-A. Gustave, S. Desage, C. Chirouze, F. Vandenesch, P. Tattevin, Catherine Chirouze, Elodie Curlier, Cécile Descottes-Genon, Bruno Hoen, Isabelle Patry, Lucie Vettoretti, Pascal Chavanet, Jean-Christophe Eicher, Sandrine Gohier-Treuvelot, Marie-Christine Greusard, Catherine Neuwirth, André Péchinot, Lionel Piroth, Marie Célard, Catherine Cornu, François Delahaye, Malika Hadid, Pascale Rausch, Audrey Coma, Florence Galtier, Philippe Géraud, Hélène Jean-Pierre, Vincent Le Moing, Catherine Sportouch, Jacques Reynes, Nejla Aissa, Thanh Doco-Lecompte, François Goehringer, Nathalie Keil, Lorraine Letranchant, Hepher Malela, Thierry May, Christine Selton-Suty, Nathalie Bedos, Jean-Philippe Lavigne, Catherine Lechiche, Albert Sotto, Xavier Duval, Emila Ilic Habensus, Bernard Iung, Catherine Leport, Pascale Longuet, Raymond Ruimy, Eric Bellissant, Pierre-Yves Donnio, Fabienne Le Gac, Christian Michelet, Matthieu Revest, Pierre Tattevin, Elise Thebault, François Alla, Pierre Braquet, Marie-Line Erpelding, Laetitia Minary, Sarah Tubiana, Michèle Bès, Jérôme Etienne, Taissia Lelekov-Boissard, Anne Tristan, François Vandenesch, Alex Van Belkum, Fernando Rivadeneira, Willem Vanwamel, Sandrine Barbas, Christine Delonca, Virginie Sussmuth, Anne Verchère
Journal: Clinical Microbiology and Infection (2018)
Abstract 14307: Periprocedural Stokes and Anticoagulation Management During AF Ablation: Results From the “Compare" Randomized Multicenter Trial
Authors: Luigi Di Biase, J. David Burkhardt, Pasquale Santangeli, Prasant Mohanty, Javier Sanchez, Rong Bai, Sanghamitra Mohanty, Chintan Trivedi, Antonio Dello Russo, Michela Casella, Richard Hongo, Salwa Beheiry, Steven Hao, Dhanunjay Lakkireddy, Madhu Reddy, Claude S Elayi, Gaetano Fassini, Claudio Tondo, Gemma Pelargonio, Rodney Horton, Maria Lucia Narducci, Jason Zagrodzky, Robert A Schweikert, Andrea Natale
Journal: Circulation (2013)

Introduction: Iatrogenic periprocedural thromboembolic (TE) events are insidious complications of catheter ablation for atrial fibrillation (AF). We sought to determine whether the type of AF and t...
Red Meat Allergy Associated With Coronary Artery Plaque
Authors: Rita Rubin
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The global response and unmet actions for HIV and sex workers
Authors: Kate Shannon, Anna-Louise Crago, Stefan D Baral, Linda-Gail Bekker, Deanna Kerrigan, Michele R Decker, Tonia Poteat, Andrea L Wirtz, Brian Weir, Marie-Claude Boily, Jenny Butler, Steffanie A Strathdee, Chris Beyrer
Journal: The Lancet (2018)
Mortality After Acute Myocardial Infarction in Hospitals That Disproportionately Treat Black Patients
Authors: JonathanSkinner, AmitabhChandra, DouglasStaiger, JulieLee, MarkMcClellan
Journal: Circulation (2005)

Background— African Americans are more likely to be seen by physicians with less clinical training or to be treated at hospitals with longer average times to acute reperfusion therapies. Less is known about differences in health outcomes. This report compares risk-adjusted mortality after acute myocardial infarction (AMI) between US hospitals with high and low fractions of elderly black AMI patients. Methods and Results— A prospective cohort study was performed for fee-for-service Medicare patients hospitalized for AMI during 1997 to 2001 (n=1 136 736). Hospitals (n=4289) were classified into approximate deciles depending on the extent to which the hospital served the black population. Decile 1 (12.5% of AMI patients) included hospitals without any black AMI admissions during 1997 to 2001. Decile 10 (10% of AMI patients) included hospitals with the highest fraction of black AMI patients (33.6%). The main outcome measures were 90-day and 30-day mortality after AMI. Patients admitted to hospitals disproport...
Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial
Authors: Janusz A Z Jankowski, John de Caestecker, Sharon B Love, Gavin Reilly, Peter Watson, Scott Sanders, Yeng Ang, Danielle Morris, Pradeep Bhandari, Claire Brooks, Stephen Attwood, Rebecca Harrison, Hugh Barr, Paul Moayyedi, Krish Ragunath, Bashir Rameh, Grant Fullarton, Art Tucker, Ian Penman, Colin Rodgers, James Neale, Cathryn Edwards, Adelyn Wise, Stephen Jones, Nicholas Church, Kishor Vaidya, Sherzad Balata, John Todd, Michael Gibbons, David Johnston, Mark Anderson, Gareth Davies, William Dickey, Andrew Murdock, Graham Turner, Andrew Goddard, Stephen Gore, Chris Haigh, Timothy Harding, Lucina Jackson, Iain Murray, Joy Worthingon, Thomas Lee, Peik Loon Lim, James McLoughlin, Christopher Macdonald, Philip Mairs, David Monk, Sean Preston, Stirling Pugh, Howard Smart, Ashraf Soliman, Peter Isaacs, David Aldulaimi, Nigel Trudgill, Julian Teare, Abduljalil Benhamida, Andrew Bell, Robert Boulton-Jones, Tawfique Daneshmend, Hisaharu Suzuki, Sue Cullen, Rebecca Fitzgerald, Rupert Ransford, Mohammad Mesbahur Rahman, Giovanni Domenico Tebala, Michael Hallissey, Carrie Kelly, Tamas Hickish, Ali Taha, Johan Rademaker, Mark Whitehead, Sean Kelly, Perminder Phull, Naveen Sharma, Ian Perry, Vankatraman Sankara-Raman, Haythem Ali, Iqbal Khan, Howard Curtis, Martin Wadley, Adam Stone, Sumesh Sukumaran, Andrew Higham, Stephen Lewis, Adam Haycock, Bernhard Usselmann, Simon Douglas Johnston, Tony Tham, Stewart Campbell, Andrew Douds, Jason Dunn, Ian Sargeant, Mark Narain, Nick Maynard, Andrew Chilton, Susi Green, Duncan Loft, Bart Decadt, Michael Mendall, Mathis Heydtmann, Neil Fisher
Journal: The Lancet (2018)

Oesophageal adenocarcinoma is the sixth most common cause of cancer death worldwide and Barrett's oesophagus is the biggest risk factor. We aimed to evaluate the efficacy of high-dose esomeprazole proton-pump inhibitor (PPI) and aspirin for improving outcomes in patients with Barrett's oesophagus.
Clonal hematopoiesis in patients with rheumatoid arthritis
Authors: Paula Savola, Sofie Lundgren, Mikko A. I. Keränen, Henrikki Almusa, Pekka Ellonen, Marjatta Leirisalo-Repo, Tiina Kelkka, Satu Mustjoki
Journal: Blood Cancer Journal (2018)

Clonal hematopoiesis (CH) is a phenomenon in which somatic mutations originating from hematopoietic progenitors are detected in peripheral blood cells 1,2 .The prevalence of CH increases with age, and CH can be detected in 10-25% of healthy, elderly individuals [1][2][3][4] .Very sensitive methods may allow somatic mutation detection in blood cells in 95% of 50-60-year olds 5 .CH confers risk for myeloid malignancy and death 1,2 .In addition, recent data has suggested that CH is also a risk factor for cardiovascular disease 1,6,7 .In mice, Tet2 loss-offunction in myeloid cells alone promoted atherosclerosis and proinflammatory cytokine production 6 .Proinflammatory and dysregulated immune responses play roles in the pathogenesis of multiple diseases.As an example, rheumatoid arthritis (RA) is a chronic autoimmune disease which leads to joint destruction.Despite improved disease outcomes with modern treatments, RA patients have increased risk for death and cardiovascular disease.CH has not been studied in the context of RA previously, except for one study containing self-reported disease history of arthritis 3 .Aplastic anemia (AA) and hypoplastic myelodysplastic syndrome (hMDS) are characterized by hypocellular bone marrow and peripheral-blood cytopenias, and are difficult to distinguish 8 .Although T cells cause hematopoietic stem cell destruction in AA, cytogenetic abnormalities occur in 4-11%, and CH occurs in up to 50% of AA cases 8 .AA confers a substantial risk for hematological malignancy 8 .
Abstract 18942: Coronary CT Angiography versus Stress Imaging for Initial Risk Stratification (CT-FIRST): A Randomized Prospective Trial on Downstream Resource Utilization
Authors: Todd C Villines, Rosco Gore, Jody Bindeman, Michael Cheezum, Binh Nguyen, Patrick J Devine, Allen J Taylor
Journal: Circulation (2013)

Introduction: Noninvasive stress myocardial imaging studies are commonly utilized to evaluate patients with chest pain. While coronary computed tomographic angiography (CTA) is highly accurate for the diagnosis of coronary artery disease (CAD), its comparative effectiveness versus stress imaging on downstream resource utilization is undefined. Hypothesis: We assessed the hypothesis that coronary CTA may be associated with lower downstream resource utilization as compared to stress imaging. Methods: We randomized 240 adults without prior CAD who were clinically referred for stress imaging (single photon emission computed tomography [SPECT] or stress echocardiography) to subsequent 64-slice CTA versus stress imaging alone (1:1). CTA readers were blinded to clinical and stress test results and patients were prospectively followed over 24 months for the primary outcome of mean per-patient downstream clinical evaluations and additional cardiac testing (composite) for the initial anginal complaint. Results: Patient were of mean age 52 ± 9 years (58% male) with mean pre-test probability (Diamond-Forrester) of 44 ± 20%. Most (67%) underwent SPECT (86% exercise), with 37% undergoing exercise stress echocardiography. Stress imaging studies demonstrated ischemia in 5% of subjects. Coronary CTA was normal in 52% with 40%, 5% and 1% having mild (&lt;50%), moderate (50-69%) and severe (&gt;70%) stenosis, respectively. Most patients (67%) underwent no further posttest evaluation. Coronary CTA was associated with significantly fewer total downstream encounters (0.4; 95% CI -0.5-1.4) versus no CTA (1.3; 0.9-1.6; p=0.02) and fewer clinic and emergency room visits per-subject (0.29 vs. 1.03; p=0.04). Downstream stress tests, catheterizations, revascularizations and acute coronary events were similar between groups. Discrepancies between CTA and stress imaging were rare (3 abnormal SPECT with normal CTA) and 9% of CTA patients required follow-up for incidental findings. There were no significant differences in aspirin or statin medication utilization. Conclusions: Among a stable symptomatic cohort with low CAD prevalence undergoing stress imaging, coronary CTA was associated with incrementally lower rates of downstream clinical evaluations.
Transient Occlusion of the Middle Cerebral Artery by Macroembolism During Carotid Stenting for Traumatic Dissection of the Common Carotid Artery
Authors: EisukeFurui, YoshikazuOkamoto, ShinyaKida, JunkohYamashita, OsamuMatsui, MasahitoYamada
Journal: Circulation (2005)
Abstract 256: Xpln a New Target Protein in the Pathogenesis of Cardiac Dysfunction
Authors: Mirjam Seiz, H.a. Katus, M. Voelkers
Journal: Circulation Research (2017)

Backround: mTOR (mammalian target of rapamycin) is an essential multiprotein complex in cells. It consists in two different complexes, mTORC1 and mTORC2, each with distinct cellular functions. mTORC1 is important for protein synthesis, whereas mTORC2 influences cell survival. Both are important for maintaining cell homeostasis. A negative feedback mechanism between the mTORC1/mTORC2 is indispensable for controlled activity of the protein complex. Adrenergic overstimulation of mTORC1 contributes to severity of myocardial damage, including cardiac hypertrophy and heart failure. Thus the regulatory influence of mTORC2 seems to be important for physiological mTORC1 activation. Hypothesis: The activation of mTORC2 affects the pathogenesis of cardiac dysfunction. Therefore XPLN, a new found mTORC2 Inhibitor, could prove as a pivotal regulator protein for the mTOR complex and cardiac function. Methods: Combined pharmacological and molecular biological methods were used for disruption of the mTORC1/mTORC2 equilibrium. The experiments were performed in cultured cardiac myocytes as well as in human samples. Gain and loss of function of XPLN was used for demonstrating it′s relevance on mTORC2 regulation and the functionally consequence of mTORC1/mTORC2 interconnection. The importance of the mTORC equilibrium was demonstrated by application of pathological growth factors (Phenylephrine). mTORC2 inhibition after XPLN overexpression resulted in mTORC1 activation, hypertrophic cell formation and cardiac stress. Conversely, knockdown of XPLN results in shifting toward mTORC2 activation with significant reduction in BNP expression. Conclusion: The regulatory influence of mTORC2 is essential for physiological mTORC1/mTORC2 activation. Disruption of this equilibrium results in myocardial stress. We demonstrate XPLN as a potent mTORC2 inhibitor with significant influence on the mTORC2 regulation. Furthermore we could show it′s relevant consequences in cell survival and the extensive effects on mTORC1 activation. Therefore XPLN is an essential regulator protein in the pathogenesis of cardiac dysfunction and could prove as a new target protein for medical treatment.
Author Correction: Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates
Authors: Marnix Lameijer, Tina Binderup, Mandy M. T. van Leent, Max L. Senders, Francois Fay, Joost Malkus, Brenda L. Sanchez-Gaytan, Abraham J. P. Teunissen, Nicolas Karakatsanis, Philip Robson, Xianxiao Zhou, Yuxiang Ye, Gregory Wojtkiewicz, Jun Tang, Tom T. P. Seijkens, Jeffrey Kroon, Erik S. G. Stroes, Andreas Kjaer, Jordi Ochando, Thomas Reiner, Carlos Pérez-Medina, Claudia Calcagno, Edward A. Fisher, Bin Zhang, Ryan E. Temel, Filip K. Swirski, Matthias Nahrendorf, Zahi A. Fayad, Esther Lutgens, Willem J. M. Mulder, Raphaël Duivenvoorden
Journal: Nature Biomedical Engineering (2018)
Evidence Against the Use of Fluoroquinolones in Patients With Aortic Pathology
Authors: Gilbert R. Upchurch
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Allergic conversion of protective mucosal immunity against nasal bacteria in patients with chronic rhinosinusitis with nasal polyposis
Authors: Kazuya Takeda, Shuhei Sakakibara, Kazuo Yamashita, Daisuke Motooka, Shota Nakamura, Marwa Ali El Hussien, Jun Katayama, Yohei Maeda, Masanobu Nakata, Shigeyuki Hamada, Daron M. Standley, Masaki Hayama, Takashi Shikina, Hidenori Inohara, Hitoshi Kikutani
Journal: Journal of Allergy and Clinical Immunology (2018)
Human <i>CPA1</i> mutation causes digestive enzyme misfolding and chronic pancreatitis in mice
Authors: Eszter Hegyi, Miklós Sahin-Tóth
Journal: Gut (2018)

Objective Chronic pancreatitis is a progressive, relapsing inflammatory disorder of the pancreas, which often develops in the background of genetic susceptibility. Recently, loss-of-function mutations in CPA1 , which encodes the digestive enzyme carboxypeptidase A1, were described in sporadic early onset cases and in hereditary pancreatitis. Mutation-induced misfolding of CPA1 and associated endoplasmic reticulum (ER) stress was suggested as potential disease mechanism; however, in vivo evidence has been lacking. The objective of the present study was to create a mouse model that recapitulates features of CPA1 -associated chronic pancreatitis. Design We knocked-in the most frequently occurring p.N256K human CPA1 mutation to the mouse Cpa1 locus. Mutant mice were characterised with respect to pancreas pathology and ER stress and compared with C57BL/6N and CPA1 null control mice. Results In the CPA1 N256K mutant mice, we observed hallmarks of chronic pancreatitis that included progressive acinar cell atrophy, inflammatory cell infiltration, fibrosis and acinar-ductal metaplasia. In contrast, similarly to the C57BL/6N mice, the CPA1 null control strain exhibited no signs of pancreatic disease. Mutation p.N256K induced misfolding of mouse CPA1 and resulted in elevated expression of ER stress markers Hspa5 (BiP) and Ddit3 (CHOP) both in cell culture and mutant mice. Conclusion The results offer categorical evidence that CPA1 mutations elicit enzyme misfolding and cause chronic pancreatitis via an ER stress-related mechanism.
Novel Bioinformatics Approach Identifies Transcriptional Profiles of Lineage-Specific Transposable Elements at Distinct Loci in the Human Dorsolateral Prefrontal Cortex
Authors: Guia Guffanti, Andrew Bartlett, Torsten Klengel, Claudia Klengel, Richard Hunter, Gennadi Glinsky, Fabio Macciardi
Journal: Molecular Biology and Evolution (2018)

Expression of transposable elements (TE) is transiently activated during human preimplantation embryogenesis in a developmental stage- and cell type-specific manner and TE-mediated epigenetic regulation is intrinsically wired in developmental genetic networks in human embryos and embryonic stem cells. However, there are no systematic studies devoted to a comprehensive analysis of the TE transcriptome in human adult organs and tissues, including human neural tissues. To investigate TE expression in the human Dorsolateral Prefrontal Cortex (DLPFC), we developed and validated a straightforward analytical approach to chart quantitative genome-wide expression profiles of all annotated TE loci based on unambiguous mapping of discrete TE-encoded transcripts using a de novo assembly strategy. To initially evaluate the potential regulatory impact of DLPFC-expressed TE, we adopted a comparative evolutionary genomics approach across humans, primates, and rodents to document conservation patterns, lineage-specificity, and colocalizations with transcription factor binding sites mapped within primate- and human-specific TE. We identified 654,665 transcripts expressed from 477,507 distinct loci of different TE classes and families, the majority of which appear to have originated from primate-specific sequences. We discovered 4,687 human-specific and transcriptionally active TEs in DLPFC, of which the prominent majority (80.2%) appears spliced. Our analyses revealed significant associations of DLPFC-expressed TE with primate- and human-specific transcription factor binding sites, suggesting potential cross-talks of concordant regulatory functions. We identified 1,689 TEs differentially expressed in the DLPFC of Schizophrenia patients, a majority of which is located within introns of 1,137 protein-coding genes. Our findings imply that identified DLPFC-expressed TEs may affect human brain structures and functions following different evolutionary trajectories. On one side, hundreds of thousands of TEs maintained a remarkably high conservation for ∼8 My of primates' evolution, suggesting that they are likely conveying evolutionary-constrained primate-specific regulatory functions. In parallel, thousands of transcriptionally active human-specific TE loci emerged more recently, suggesting that they could be relevant for human-specific behavioral or cognitive functions.
Hepatocellular Carcinoma as a Complication of Vascular Disease of the Liver After Fontan Procedure
Authors: Chiara Mazzarelli, Mary D. Cannon, Mark Hudson, Nigel Heaton, Debashis Sarker, Pauline Kane, Alberto Quaglia, Abid Suddle
Journal: Hepatology (2018)

Mazzarelli, Chiara; Cannon, Mary D.; Hudson, Mark; Heaton, Nigel; Sarker, Debashis; Kane, Pauline; Quaglia, Alberto; Suddle, Abid Author Information