tbuckley/cabot-search huggingface dataset:
Abstract 365: Change in Saturation of Oxygen and Patent Foramen Ovale in Postural Orthostatic Tachycardia Syndrome
Authors: Mu’taz F AbuAlSha’r, Ra’ed K Abu-Jajeh, Mo’yed N Ahmad, Chandralekha Ashangari, Stacy E Hamid, Amer Suleman
Journal: Circulation Research (2017)

Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a constellation of signs and symptoms that occurs when the patient stands upright. It affects primarily young women. On the other hand, PFO is a hidden condition that doesn’t cause signs and symptoms in most cases. Method: 331 POTS patients were randomly selected during the period of June 2014 to April 2016 from our clinic and they underwent PFO test. In addition to that, patients underwent tilt test with SPO2 recordings every 2 minutes until 10 minutes to calculate the change in SpO2 of that period of time. Results: Out of 331 patients, 292 patients were females (88%; n=292 age 32.48 ± 10.78), 39 patients were males (12%; n=39 age 28.87 ± 11.69). 136 patients (41%) had no drop in their SPO2 and 17 of 136 patients had positive(+) PFO test (Grade 1 PFO in 4 patients, Grade 2 PFO in 2 patients, Grade 3 PFO in 3 patients and Grade 4 PFO in 8 patients). 77 patients (23%) had a drop of 1% in their SPO2 and 11 of 77 patients had + PFO test (Grade 1 PFO in 3 patients, Grade 2 PFO in 1 patient, Grade 3 PFO in 2 patients and Grade 4 PFO in 5 patients). 46 patients (14%) had a drop of 2% in their SPO2 and 10 of 46 patients had + PFO test (Grade 1 PFO in 2 patients, Grade 3 PFO in 2 patients and Grade 4 PFO in 6 patients). 16 patients (5%) had a drop of 3% in their SPO2 and 3 of 16 patients had + PFO test (Grade 1 PFO in 1 patient, Grade 2 PFO in 1 patient, Grade 3 PFO in 1 patient). 9 patients (3%) had a drop of 4% in their SPO2 and 1 of 9 patients had + PFO test (Grade 2). 5 patients (1.5%) had a drop of 5% in their SPO2 and 2 out of 5 patients had + PFO test (Grade 1 PFO in 1 patient and Grade 4 PFO in 1 patient). 2 patients (0.6%) had a drop of 6% in their SPO2 and both of them had + PFO test (Grade 2 PFO in 1 patient, Grade 4 PFO in 1 patient). 40 patients (12%) had a rise in their SPO2 and 4 of 40 patients had + PFO test (Grade 2 PFO in 2 patients, Grade 3 PFO in 1 patient and Grade 4 PFO 1 patient). Conclusion: Our research results demonstrated that 15% of patients with POTS have PFO. Though orthodeoxia is relatively uncommon, this study demonstrated orthodeoxia in 59% of patients. Only 2% patients showed orthodeoxia of &gt;5%, but further studies should be done to define the clinical significance of the study.
Multiphoton imaging provides a superior optical biopsy to that of confocal laser endomicroscopy imaging for colorectal lesions
Authors: Jun Yan, Xiaoling Zheng, Zhangyuanzhu Liu, Wenju Liu, Dajia Lin, Dexin Chen, Kai Li, Wei Jiang, Zhiming Li, Ning Zuo, Gang Chen, Jianping Lu, Jianxin Chen, Guoxin Li, Chris Xu, Shuangmu Zhuo
Journal: Endoscopy (2018)

Abstract Background Confocal laser endomicroscopy (CLE) requires fluorescence agents, the use of which leads to blurred images and low diagnostic accuracy owing to fluorescein leakage. We aimed to explore whether multiphoton imaging (MPI) could serve as a better method of optical biopsy. Methods First, a pilot study was performed to set up the optical diagnostic criteria of MPI for benign or malignant colorectal lesions in 30 patients. Then, a blinded study was conducted to compare the sensitivity, specificity, and accuracy of MPI versus CLE imaging in 79 patients. Results In the pilot study, MPI revealed regular tissue architecture and cell morphology in the normal tissue, and irregular tubular structures, and cellular and nuclear pleomorphism in the abnormal tissue. In the blinded study, compared with CLE imaging, MPI significantly improved the diagnostic sensitivity, specificity, and accuracy of the optical biopsy (89.74 % vs. 61.54 %, P = 0.008; 92.5 % vs. 67.5 %, P = 0.009; and 91.14 % vs. 64.56 %, P = 0.001, respectively). Conclusions MPI can provide a superior optical biopsy to that of CLE imaging for colorectal lesions.
Establish enteral feeding
Authors: M. Edmonds
Journal: BMJ (1995)

Diabetic gastroparesis refractory to medical treatment is a rare but major management problem. Its previously poor prognosis, however, has been improved recently by the use of percutaneous endoscopic gastrojejunostomy with enteral feeding.1

In patients presenting with intractable vomiting it is important in the planning of management that the cause of vomiting is clearly established. Features in this case which point to a diagnosis of gastroparesis are the history of vomiting food that had been consumed a few days earlier, the large amount of residue in the stomach on gastroscopy in the absence of mechanical obstruction or mucosal abnormalities, delayed gastric emptying on scintigraphic studies, difficulties in diabetic control resulting from …
Stroke Rehab Lacking
Authors: Bridget Kuehn
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LEARNING ERCP WITH THE BOŠKOSKI-COSTAMAGNA MECHANICAL SIMULATOR: A SINGLE TRAINEE'S EXPERIENCE
Authors: D Gregoire, G Rateb
Journal: Endoscopy (2018)

Obtaining sufficient competence for ERCP practice requires long training and entails some well-known risks for patients. Numerous mechanical or electronic training modules have been developed recently to enhance ERCP learning curve with interesting results. In this study we have evaluated the impact of exposure to the Boškoski-Costamagna mechanical simulator on an ERCP trainee's learning curve.
Fluoxetine and extrapyramidal side effects
Authors: D M Coulter, P I Pillans
Journal: American Journal of Psychiatry (1995)

The authors' goal was to determine whether fluoxetine is associated with extrapyramidal side effects.They assessed the notifications of extrapyramidal manifestations in patients given fluoxetine in the New Zealand Intensive Medicines Monitoring Programme, a national system that monitored adverse reactions associated with fluoxetine over a 4-year period, and determined whether these adverse reactions were causally related to fluoxetine.In reports of adverse reactions in 5,555 patients given fluoxetine throughout New Zealand, there were 15 notifications of extrapyramidal events probably or possibly caused by fluoxetine. Fluoxetine was the only psychotropic agent used for seven of the 15 patients; two patients were also taking lithium, four were taking neuroleptics, two were taking tricyclic antidepressants, and one was taking metoclopramide.The authors conclude that fluoxetine may be associated with extrapyramidal reactions. These may occur with fluoxetine alone or fluoxetine may facilitate the reaction in patients receiving psychotropic medication or dopamine receptor blocking drugs.
Assessment of the Risk of Rhabdomyolysis and Myopathy During Concomitant Treatment with Ticagrelor and Statins
Authors: Dorota Danielak, Marta Karaźniewicz-Łada, Franciszek Główka
Journal: Drugs (2018)

The introduction of ticagrelor, one of the first directly-acting oral antiplatelet drugs, provided new possibilities in the prevention of thrombotic events in patients with acute coronary syndromes (ACS). Current guidelines recommend ticagrelor in dual antiplatelet therapy with aspirin over clopidogrel for prevention of stent thrombosis in patients with ACS. Moreover, in the management of ACS, lipid-lowering treatment with high-intensity statin therapy is advised for secondary prevention of cardiovascular events over the long term. Despite the apparent advantages of combined antiplatelet and lipid-lowering treatments, a possible interaction between statins and ticagrelor may lead to myopathy and rhabdomyolysis. In this review, relevant information was gathered on the ticagrelor-statin interaction that might lead to this life-threatening condition. This review focuses on the most widely used statins—simvastatin, atorvastatin, and rosuvastatin. Possible mechanisms of this interaction are discussed, including CYP3A4 isoenzymes, organic anion transporter polypeptide (OATPs), P-glycoprotein and glucuronidation. PubMed database was searched for relevant case reports and all data gathered from the introduction of ticagrelor to March 2018 are presented and discussed. In summary, co-administration of statins and ticagrelor was found to be relatively safe in routinely prescribed doses. However, caution should be exercised, especially in elder populations.
Neuromedin U directly induces degranulation of skin mast cells, presumably via <scp>MRGPRX</scp>2
Authors: Yoshimi Matsuo, Yuhki Yanase, Reiko Irifuku, Shunsuke Takahagi, Shoji Mihara, Kaori Ishii, Tomoko Kawaguchi, Akio Tanaka, Kazumasa Iwamoto, Haruka Watanuki, Kazuyuki Furuta, Satoshi Tanaka, Asuka Inoue, Junken Aoki, Michihiro Hide
Journal: Allergy (2018)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Treatment of tardive dyskinesia with lecithin
Authors: I V Jackson, E A Nuttall, I O Ibe, J Perez-Cruet
Journal: American Journal of Psychiatry (1979)

Six patients with moderate or severe tardive dyskinesia participated in a 14-day double-blind crossover comparison of placebo with 50 g/day of lecithin. There were no side effects, and Abnormal Involuntary Movement Scale (AIMS) ratings of videotaped examinations indicated significant improvement in the dyskinesias of all subjects during the lecithin trial, even with concomitant administration of a constant dose of neuroleptic medication to five patients.
Experiencia de 5 años en enteroscopia en un hospital de tercer nivel
Authors: Y García De La Rosa, P Estévez Boullosa, A Martínez, D Martínez, A Rincón, L De Castro, JA Hermo, I Martín-Granizo, L Cid, I Rodríguez-Prada
Journal: Endoscopy (2017)

La enteroscopia es una herramienta endoscópica segura y eficaz para intervenciones diagnósticas y terapéuticas. En la literatura las indicaciones más frecuentes son la sospecha de hemorragia de intestino delgado tanto visible como oculta, y los hallazgos endoscópicos más frecuentes son lesiones vasculares y erosiones-úlceras.
Abstract 18985: Extracellular Volume Fraction Evaluated by T1-Mapping Determines Left Ventricular Stiffness and is Associated With Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction
Authors: Taku Omori, Kaoru Dohi, Naoki Fujimoto, Shiro Nakamori, Masaki Ishida, Naoto Kumagai, Yasutaka Ichikawa, Kakuya Kitagawa, Norikazu Yamada, Hajime Sakuma, Masaaki Ito
Journal: Circulation (2016)

Introduction: In patients with heart failure with preserved ejection fraction (HFpEF), increased left ventricular (LV) stiffness can be a potential therapeutic target. However, noninvasive assessme...
Conditional Survival as a Pragmatic Resource for Cancer Survivors and Health Care Professionals
Authors: Charles R. Thomas
Journal: JAMA Oncology (2018)

Causes of Death and Conditional Survival Estimates of Medium-and Long-term Survivors of Pancreatic AdenocarcinomaMost patients who undergo resection of pancreatic ductal adenocarcinoma (PDAC) die within 5 years. [1]2][3][4][5] Five-year survivors remain at risk for PDAC-related death, 1,2,4,5 and recurrences more than 15 years after diagnosis are reported. 4 A study reporting conditional survival (CS) extended only 6.5 years after diagnosis. 3Reported 10-year survival rates range from 3.9% in a National Cancer Database (NCDB) study to 12% to 13% in singleinstitution studies. 1,5,6 In the NCDB study, the risk of death decreased for 6 years and then remained fairly constant at 10% per year in years 7 to 15, which was double that of an age-and sexmatched general population. 6 Limited prognostic information exists for 5-to 15-year survivors.We used the Surveillance, Epidemiology, and End Results (SEER) database (http://www.seer.cancer.gov) to quantify yearly risks of death due to PDAC vs other causes and calculate CS estimates extending 21 years after diagnosis.
Evolutionary history of human colitis-associated colorectal cancer
Authors: Ann-Marie Baker, William Cross, Kit Curtius, Ibrahim Al Bakir, Chang-Ho Ryan Choi, Hayley Louise Davis, Daniel Temko, Sujata Biswas, Pierre Martinez, Marc J Williams, James O Lindsay, Roger Feakins, Roser Vega, Stephen J Hayes, Ian P M Tomlinson, Stuart A C McDonald, Morgan Moorghen, Andrew Silver, James E East, Nicholas A Wright, Lai Mun Wang, Manuel Rodriguez-Justo, Marnix Jansen, Ailsa L Hart, Simon J Leedham, Trevor A Graham
Journal: Gut (2018)

IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic CRC (S-CRC). Here we have dissected the evolutionary history of CA-CRC using multiregion sequencing.
Study did not consider treatment efficacy
Authors: L. F Gram, P. Kragh-Sorensen, G. Isacsson, U. Bergman
Journal: BMJ (1995)

populations, with variable doses and durations, which creates further difficulty in interpreting such data.We therefore conclude that it is not possible to state with certainty which of the seven most commonly prescribed non-steroidal antiinflammatory drugs is the safest; six of these seven have similar profiles of adverse events.
Striatal D2 dopaminergic receptors assessed with positron emission tomography and [76Br]bromospiperone in untreated schizophrenic patients
Authors: J L Martinot, P Peron-Magnan, J D Huret, B Mazoyer, J C Baron, J P Boulenger, C Loc'h, B Maziere, V Caillard, H Loo
Journal: American Journal of Psychiatry (1990)

Striatal D2 dopaminergic receptors of 12 drug-free schizophrenic patients and 12 normal subjects were investigated with positron emission tomography and [76Br]bromospiperone. Patients were classified according to DSM-III criteria, and their clinical symptoms were rated according to Andreasen's negative and positive symptom scales. The ratio of striatal to cerebellar radioactivity was taken as an index of striatal D2 dopamine receptor density. There was no significant difference between the control subjects and the overall schizophrenic group and no significant relationship between this index and the symptom ratings. However, state-dependent variables could partly account for the striatal D2 receptor density variability.
Capacitación en la técnica “peroral endoscopic myotomy” (POEM) en modelo animal
Authors: P Miranda García, JA Moreno Monteagudo, F De La Morena Lopez, J Mendoza Jimenez-Ridruejo, C Santander Vaquero
Journal: Endoscopy (2017)

La miotomía peroral endoscópica (POEM) es una técnica utilizada en el tratamiento de trastornos motores esofágicos, es compleja y requiere un alto nivel de aprendizaje. Presentamos nuestra experiencia en etapa preclínica.
Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors
Authors: Susan J. Curry, Alex H. Krist, Douglas K. Owens, Michael J. Barry, Aaron B. Caughey, Karina W. Davidson, Chyke A. Doubeni, John W. Epling, Alex R. Kemper, Martha Kubik, C. Seth Landefeld, Carol M. Mangione, Michael Silverstein, Melissa A. Simon, Chien-Wen Tseng, John B. Wong
Journal: JAMA (2018)

<h3>Importance</h3> Cardiovascular disease (CVD) is the most common cause of death among adults in the United States. Treatment to prevent CVD events by modifying risk factors is currently informed by the Framingham Risk Score, the Pooled Cohort Equations, or similar CVD risk assessment models. If current CVD risk assessment models could be improved by adding more risk factors, treatment might be better targeted, thereby maximizing the benefits and minimizing the harms. <h3>Objective</h3> To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on using nontraditional risk factors in coronary heart disease risk assessment. <h3>Evidence Review</h3> The USPSTF reviewed the evidence on using nontraditional risk factors in CVD risk assessment, focusing on the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) level, and coronary artery calcium (CAC) score; the health benefits and harms of CVD risk assessment and treatment guided by nontraditional risk factors combined with the Framingham Risk Score or Pooled Cohort Equations compared with using either risk assessment model alone; and whether adding nontraditional risk factors to existing CVD risk assessment models improves measures of calibration, discrimination, and risk reclassification. <h3>Findings</h3> The USPSTF found adequate evidence that adding the ABI, hsCRP level, and CAC score to existing CVD risk assessment models results in small improvements in discrimination and risk reclassification; however, the clinical meaning of these changes is largely unknown. Evidence on adding the ABI, hsCRP level, and CAC score to the Pooled Cohort Equations is limited. The USPSTF found inadequate evidence to assess whether treatment decisions guided by the ABI, hsCRP level, or CAC score, in addition to risk factors in existing CVD risk assessment models, leads to reduced incidence of CVD events or mortality. The USPSTF found adequate evidence to conceptually bound the harms of early detection and interventions as small. The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of using the ABI, hsCRP level, or CAC score in risk assessment for CVD in asymptomatic adults to prevent CVD events. <h3>Conclusions and Recommendation</h3> The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ABI, hsCRP level, or CAC score to traditional risk assessment for CVD in asymptomatic adults to prevent CVD events. (I statement)
Revisión de una serie de gastroscopias con hemostasia en úlceras gastroduodenales realizadas a lo largo de dos años en un hospital secundario de Madrid
Authors: M Calvo Íñiguez, S Kheiri Vázquez, C Golmayo Flethes, C Pérez Santamaría, D Fuentes Núñez, MT García Gallego, L Igualada Escribano, P García Centeno, A Castellano López, E Poves Martínez
Journal: Endoscopy (2017)

La hemorragia digestiva alta no varicosa supone la principal causa de sangrado digestivo. La etiología más frecuente es la enfermedad péptica. El tratamiento endoscópico, junto con el médico de soporte, constituye la terapia de elección.
TIGIT immune checkpoint blockade restores CD8+ T-cell immunity against multiple myeloma
Authors: Camille Guillerey, Heidi Harjunpää, Nadège Carrié, Sahar Kassem, Tricia Teo, Kim Miles, Sophie Krumeich, Marianne Weulersse, Marine Cuisinier, Kimberley Stannard, Yuan Yu, Simone A. Minnie, Geoffrey R. Hill, William C. Dougall, Hervé Avet-Loiseau, Michele W. L. Teng, Kyohei Nakamura, Ludovic Martinet, Mark J. Smyth
Journal: Blood (2018)
Optimal Multimodal Treatment for Desmoplastic Small Round Cell Tumors—Reply
Authors: Aung Myint Tun, Wai Lin Thein, Elizabeth Guevara
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Evaluation Of Acadesine, a Drug Stimulating Cell Autophagy, In Azacitidine(AZA)-Resistant Myelodysplastic Syndromes (MDS)
Authors: Thomas Cluzeau, Guillaume Robert, Jean Michel Karsenti, Frederic Luciano, Nicolas Mounier, Jill Patrice Cassuto, Lionel Ades, Sophie Raynaud, Pierre Fenaux, Patrick Auberger
Journal: Blood (2013)
News
Authors: C Cookson
Journal: BMJ (1993)

The World Health Organization (WHO), at a meeting in Geneva in November 1993, launched a campaign that will coordinate efforts of the pharmaceutical industry, academic research institutes, and drug regulatory bodies to find a vaginal antiviral agent that will either inactivate the human immunodeficiency virus (HIV) or prevent its attachment to vaginal cells, without harming the genital tract or killing sperm. Spermicides, such as nonoxynol 9, which kill HIV in test tubes may increase HIV transmission by harming the vaginal lining. However, this may be due to the carrier substance. Clinical research, using a protocol designed by the WHO and international regulatory authorities, will begin examining existing vaginal microbicides. Other candidates include sulphated polysaccharides and reverse transcriptase inhibitors. Included are comments by Dr. Michael Merson and Prof. Don Jefferies. The meeting was organized by the United Kingdom's Medical Research Council and Department of Health.
Rentabilidad de la ECO-PAAF para lesiones sólidas pancreáticas sin citólogo en sala
Authors: B Merchán Gómez, JM Esteban López-Jamar, M Vazquez Romero, JL Mendoza Hernández, L Redero Brioso, E Rey Diaz-Rubio
Journal: Endoscopy (2017)

La punción-aspiración con aguja fina guiada por ecoendoscopia (ECO-PAAF) ha demostrado tener buena rentabilidad en el diagnóstico de masas pancreáticas cuando se dispone de estudio por citólogo en sala (ROSE). Sin embargo, el rendimiento es inferior cuando no se dispone de ROSE.