tbuckley/cabot-search huggingface dataset:
AB0735 Evaluation of psychological state of patients with ankylosing spondylitis: regional registry as a tool for improvement of management
Authors: S Lapshina, D Abdulganieva, L Myasoutova
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> According to modern conception "T2T" a patient with ankylosing spondylitis (AS) takes an active part in the disease treatment that determines the importance of his psychological state. <h3>Objectives</h3> To evaluate interconnection between the psychological state of the patient with AS and the disease course. <h3>Methods</h3> Within the regional registry which is a part of epidemiological study of clinical diversity of AS in Russian population, 40 patients (32 males and 8 females) at the age of 21 to 56 years (average age 40,3±10,0) were examined. The average disease duration on the day of examination was 12,7±9,9 years, BASDAI - 5,54±1,8, BASFI – 5,34±2,48. Functional status (range of motion) was evaluated by means of BASMI. EQ-5D questionnaire was used for psychological state evaluation. <h3>Results</h3> A total of 17 (42,5%) patients had anxiety and depression: moderate – 15 (88,2%), severe – 2 (11,8%) responders. With the disease duration of less than 5 years propensity for depression and anxiety was noted by 6 out of 11 (54,5%) patients, 5 to 10 years – 2 out of 12 (16,7%), more than 10 years – 9 out of 17 (52,9%). In patients with mild disease activity anxious and depressive states were not observed, with moderate disease activity they were revealed in 3 out of 7 patients (42,8%), with severe activity – in 9 out of 21 (42,8%), with very severe activity – in 5 out of 10 (50%) responders. Among the patients without limitation of motion (BASFI) anxiety and depression was revealed in 2 out of 11 (18,2%), with moderate limitation –6 out of 18 (33,3%), with severe limitation –9 out of 11 (81,8%) patients. According to BASMI 1 out of 2 patients without limitation of motion had anxiety and depression, 6 out of 19 (31,5%) – with moderate limitation and 10 out of 19 (52,6%) with severe limitation. The direct correlation was revealed between EQ-5D score and BASFI (r=0,996) and between EQ-5D and BASDAI (r=0,855), concurrently such correlation was absent between BASMI and EQ-5D. Among the patients without anxious and depressive states 14 out of 23 (60,8%) patients take NSAIDs regularly while among the patients who noted propensity for anxiety and depression only 7 out of 17 (41,17%) take NSAIDs regularly. <h3>Conclusions</h3> Patients with short (less than 5 years) and long (more than 10 years) AS duration, severe disease activity and functional limitation are more prone to anxiety and depression. Patients with anxious and depressive states are less compliant with therapy which influences its efficacy. These data should be considered when the programs of AS patients9 management are developed. <h3>Disclosure of Interest</h3> None declared
Abstract 19511: Progesterone Reduces Isoproterenol-Induced pVTs in Male Transgenic Long QT Syndrome 2 (LQT2) Rabbits
Authors: Konstantinos Kossidas, Zhe Zheng, Katja E Odening, Manfred Zehender, Lorraine Schoffield, Chantel Taylor, Bryant Yang, Zachary Pfeiffer, Bum-Rak Choi, Gideon Koren
Journal: Circulation (2012)

Background: During childhood, boys with long QT syndrome (LQT) have a higher risk than girls for developing ventricular arrhythmia and sudden cardiac arrest. We have previously shown a pro-arrhythmic effect of estrogen (EST) and an anti-arrhythmic effect of progesterone (PROG) in transgenic female LQT2 rabbits. Here we study the effects of sex hormones in male LQT2 rabbits; hypothesizing that orchiectomy (ORCH) will increase the arrhythmogenic risk as compared to treatment with PROG or dihydrotestosterone (DHT). Methods: Orchiectomized LQT2 males were implanted with 90-day release pellets containing PROG (n=6), DHT (n=5), or placebo (ORCH) (n=6). All groups underwent dual voltage-calcium optical mapping ex vivo after 8 weeks of hormone-treatment. Results: During 8 weeks of hormone-treatment, no episodes of SCD occurred in any groups. Optical mapping revealed similar APD and APD dispersion in all groups (APD, ms, ORCH 239.9±29.2, DHT 251.4±15.7, PROG 253.0±19.9) (APD dispersion, ms, ORCH 30.7±6.8, DHT 33.1±5.70, PROG 34.1±6.0). Isoproterenol induced calcium and voltage oscillations during the second phase of the AP in all three groups (Fig.1), However, the duration of the induced pVT was longer in ORCH rabbits as compared to PROG (5.8±4.8 sec vs. 2.1±1.3 sec p&lt;0.05, n=6). By contrast, DHT had no beneficial effect (3.2±1.1 sec p=0.131 ORCH vs DHT n=5). Western blot analyses revealed that male rabbit heart express PROG nuclear receptors. Conclusion: Orchiectomy sensitized male LQT2 rabbits to isoproterenol-induced arrhythmias. PROG reduced the duration of pVT, but did not uncouple calcium and voltage oscillations as it does in ovariectomized female LQT2 rabbits.
Dermatologic Radiotherapy and Radioactive Quackery—Discovery and Tragedy at the Turn of the 20th Century
Authors: Kishore L. Jayakumar, Sara S. Samimi
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy
Authors: Ying Zhang, Raj Kurupati, Ling Liu, Xiang Yang Zhou, Gao Zhang, Abeer Hudaihed, Flavia Filisio, Wynetta Giles-Davis, Xiaowei Xu, Giorgos C. Karakousis, Lynn M. Schuchter, Wei Xu, Ravi Amaravadi, Min Xiao, Norah Sadek, Clemens Krepler, Meenhard Herlyn, Gordon J. Freeman, Joshua D. Rabinowitz, Hildegund C.J. Ertl
Journal: Cancer Cell (2017)
Dose Escalation of Antidepressants in Unipolar Depression: A Meta-Analysis of Double-Blind, Randomized Controlled Trials
Authors: Markus Dold, Lucie Bartova, Rainer Rupprecht, Siegfried Kasper
Journal: Psychotherapy and Psychosomatics (2017)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; As many patients with unipolar depression do not respond sufficiently to initial antidepressant monotherapy, a dose increase of the current administered antidepressant (dose escalation, high-dose treatment) is frequently carried out as next treatment measure. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We conducted a meta-analysis which included all double-blind randomized controlled trials (RCTs) comparing a dose increase of antidepressants directly to continuation of standard-dose treatment in unipolar depressive patients who were non- responders to standard-dose pharmacotherapy. A mean change in the Hamilton Rating Scale for Depression (HAM-D) total score was the primary outcome. Secondary outcomes were response rates and discontinuation rates due to any reason, inefficacy, and adverse effects. Hedges g and risk ratios were calculated as effect sizes. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Seven double-blind RCTs (8 study arms) representing 1,208 participants were included. Fluoxetine (&lt;i&gt;N&lt;/i&gt; [number of studies] = 2, &lt;i&gt;n&lt;/i&gt; [number of patients] = 448), sertraline (&lt;i&gt;N&lt;/i&gt; = 2, &lt;i&gt;n&lt;/i&gt; = 272), paroxetine (&lt;i&gt;N&lt;/i&gt; = 2, &lt;i&gt;n&lt;/i&gt; = 146), duloxetine (&lt;i&gt;N&lt;/i&gt; = 1, &lt;i&gt;n&lt;/i&gt; = 255), and maprotiline (&lt;i&gt;N&lt;/i&gt; = 1, &lt;i&gt;n&lt;/i&gt; = 87) were investigated. Dose escalation was not more efficacious in HAM-D total score reduction than maintaining standard-dose treatment, neither for the pooled antidepressant group (&lt;i&gt;N&lt;/i&gt; = 7, &lt;i&gt;n&lt;/i&gt; = 999; Hedges g = -0.04, 95% CI: -0.20 to 0.12; &lt;i&gt;p&lt;/i&gt; = 0.63) nor the individual antidepressants. No differences could be determined for response rates, all-cause discontinuation, and drop-outs due to inefficacy. Significantly more patients in the dose escalation group dropped out due to adverse effects than in the standard-dose continuation group. The metaregressions indicate no influence of baseline symptom severity or amounts of dose increments on effect sizes. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; According to our meta-analytic findings, dose escalation after initial non-response to standard-dose pharmacotherapy cannot be regarded as general evidence-based treatment option in unipolar depression.
The heat shock response in neurons and astroglia and its role in neurodegenerative diseases
Authors: Rebecca San Gil, Lezanne Ooi, Justin J. Yerbury, Heath Ecroyd
Journal: Molecular Neurodegeneration (2017)

Protein inclusions are a predominant molecular pathology found in numerous neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington's disease. Protein inclusions form in discrete areas of the brain characteristic to the type of neurodegenerative disease, and coincide with the death of neurons in that region (e.g. spinal cord motor neurons in amyotrophic lateral sclerosis). This suggests that the process of protein misfolding leading to inclusion formation is neurotoxic, and that cell-autonomous and non-cell autonomous mechanisms that maintain protein homeostasis (proteostasis) can, at times, be insufficient to prevent protein inclusion formation in the central nervous system. The heat shock response is a pro-survival pathway induced under conditions of cellular stress that acts to maintain proteostasis through the up-regulation of heat shock proteins, a superfamily of molecular chaperones, other co-chaperones and mitotic regulators. The kinetics and magnitude of the heat shock response varies in a stress- and cell-type dependent manner. It remains to be determined if and/or how the heat shock response is activated in the different cell-types that comprise the central nervous system (e.g. neurons and astroglia) in response to protein misfolding events that precede cellular dysfunctions in neurodegenerative diseases. This is particularly relevant considering emerging evidence demonstrating the non-cell autonomous nature of amyotrophic lateral sclerosis and Huntington's disease (and other neurodegenerative diseases) and the destructive role of astroglia in disease progression. This review highlights the complexity of heat shock response activation and addresses whether neurons and glia sense and respond to protein misfolding and aggregation associated with neurodegenerative diseases, in particular Huntington's disease and amyotrophic lateral sclerosis, by inducing a pro-survival heat shock response.
Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure
Authors: Tianzhou Wu, Jiang Li, Li Shao, Jiaojiao Xin, Longyan Jiang, Qian Zhou, Dongyan Shi, Jing Jiang, Suwan Sun, Linfeng Jin, Ping Ye, Lingling Yang, Yinyun Lu, Tan Li, Jianrong Huang, Xiaowei Xu, Jiajia Chen, Shaorui Hao, Yuemei Chen, Shaojie Xin, Zhiliang Gao, Zhongping Duan, Tao Han, Yuming Wang, Jianhe Gan, Tingting Feng, Chen Pan, Yongping Chen, Hai Li, Yan Huang, Qing Xie, Shumei Lin, Lanjuan Li, Jun Li
Journal: Gut (2017)

The definition of acute-on-chronic liver failure (ACLF) based on cirrhosis, irrespective of aetiology, remains controversial. This study aimed to clarify the clinicopathological characteristics of patients with hepatitis B virus-related ACLF (HBV-ACLF) in a prospective study and develop new diagnostic criteria and a prognostic score for such patients.The clinical data from 1322 hospitalised patients with acute decompensation of cirrhosis or severe liver injury due to chronic hepatitis B (CHB) at 13 liver centres in China were used to develop new diagnostic and prognostic criteria.Of the patients assessed using the Chronic Liver Failure Consortium criteria with the exception of cirrhosis, 391 patients with ACLF were identified: 92 with non-cirrhotic HBV-ACLF, 271 with cirrhotic HBV-ACLF and 28 with ACLF with cirrhosis caused by non-HBV aetiologies (non-HBV-ACLF). The short-term (28/90 days) mortality of the patients with HBV-ACLF were significantly higher than those of the patients with non-HBV-ACLF. Total bilirubin (TB) ≥12 mg/dL and an international normalised ratio (INR) ≥1.5 was proposed as an additional diagnostic indicator of HBV-ACLF, and 19.3% of patients with an HBV aetiology were additionally diagnosed with ACLF. The new prognostic score (0.741×INR+0.523×HBV-SOFA+0.026×age+0.003×TB) for short-term mortality was superior to five other scores based on both discovery and external validation studies.Regardless of the presence of cirrhosis, patients with CHB, TB ≥12 mg/dL and INR ≥1.5 should be diagnosed with ACLF. The new criteria diagnosed nearly 20% more patients with an HBV aetiology with ACLF, thus increasing their opportunity to receive timely intensive management.
AB1207-HPR Patient satisfaction in a rheumatoid arthritis specialized center
Authors: S Henao, F Rodriguez, P Santos-Moreno, L Villarreal, M Cabrera, A Malpica, D Buitrago-Garcia
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> According to the Beryl Institute9s, patient experience (PX) is "the sum of all interactions, shaped by an organization9s culture, that influence patient perceptions, across the continuum of care"; nowadays patient satisfaction is considered as one of the quality for performance in health systems (1). In order to provide a multidisciplinary quality care to patients with RA in centers of excellence (CoEs) under the coordination of a rheumatologist, provide comprehensive management of patients with this pathology, ensuring approachability to medical appointments and treatment, in order to get better clinical outcomes and improve patient safety and satisfaction of the health services provided. <h3>Objectives</h3> To measure levels of satisfaction of RA patients treated at a specialized center and to evaluate patient service. <h3>Methods</h3> In a RA specialized center during a 24 month period we performed a satisfaction survey in order to evaluate the health services provided. We evaluated the timing on attention, appointment assignment, information provided, the treatment received by the healthcare team, facilities among others. Patients evaluated the services provided in a scale from 1 to 4, were 1 was very bad, 2 regular, 3 good and 4 excellent. Descriptive epidemiology was performed for each variable presented. <h3>Results</h3> We collected 1125 surveys during 2015 and 2016, 45% considered to have a timely care, the mean of waiting time for an appointment was 9 min ± 8; regarding the appointment assignment 96% of the patients evaluated it as good or excellent (mean 3.5±0.7), 80% considered that the information provided was clear and useful, 90% reported to receive a kind and friendly treatment and to considered the facilities as good or excellent. When we evaluated the satisfaction regarding the health care team 50% of patients evaluated the rheumatologist, nurse, nutritionist, physical therapist, psychologist and physiatrist as good and 40% as excellent. <h3>Conclusions</h3> Although we found that our patients are highly satisfied, there is a large opportunity to improve our services. Also, this evidence can support further research projects in order to increase the patient9s satisfaction. <h3>References</h3> Th VP. Creating the ideal patient experience. Journal of medicine and life. 2016;9(4):380–385. <h3>Disclosure of Interest</h3> None declared
AB0461 Benefits of vitamin d in sle depend on the organ system
Authors: M Petri, LS Magder
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Low 25-OH Vitamin D is associated with SLE. Both a randomized clinical trial and a longitudinal cohort study proved that supplementation reduced SLE disease activity. <h3>Objectives</h3> We examined whether Vitamin D benefits in SLE are dependent on the organ system. <h3>Methods</h3> Vitamin D and SLEDAI components were measured at each cohort visit starting in 2010 and 16,519 visits of 1,345 different patients were included. The patients were 92% female, 50% Caucasian, 41% African American. Organ-specific disease activity was defined as a set of binary variables based on SLEDAI. If the patient received any score for any component, then the patient was defined as having that type of activity. Interestingly, after adjustment for repeated measures and covariates, the relationship between vitamin D and immunologic disease activity totally disappeared. However, for skin activity, there was a significantly elevated risk among those in the very extreme levels of vitamin D. For Renal Disease Activity, there was a significantly higher rate of renal disease activity among those with low levels of vitamin D. In addition, there was a clear trend such that the higher the vitamin D, the lower the risk of renal disease activity. We then conducted a "within person" analysis. In this analysis, each person serves as his own control, and the question is: "When a person has a vitamin D level lower than his/her average, are they more likely to have renal disease activity". Note, this analysis implicitly adjusts for race, sex, and all variables (measured and unmeasured) that are invariant within a person. The results are shown in Table 2. For Renal, it appears (based on the within-person analysis), that increasing vitamin D results in a reduction in renal activity. Based on other analyses, it is clear this drop was mostly among those in the vitamin D deficiency range. <h3>Conclusions</h3> Low vitamin D is associated with cutaneous and renal SLE activity, but not with immunologic (low C3 or high anti-DNA) activity, in adjusted analyses. <h3>Disclosure of Interest</h3> None declared
THU0772-HPR Variation in rheumatology nursing care in the netherlands: a survey among nurses
Authors: Y Eijk-Hustings Van
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> EULAR recommendations for the role of nurse aim at guaranteeing a certain standard of care for people with rheumatic musculoskeletal diseases (RMDs) and at optimising the use of nursing competencies [1]. In the Netherlands, these recommendations seem well implemented. There are specialised nurses (SNs); nurses trained at a secondary vocational or Bachelor level, followed by a one-year educational program in rheumatology, and nurse practitioners (NPs), trained on a Master Level. SNs provide information, education and (psychosocial) support, but also monitoring of disease, supervised by a rheumatologist. NPs are trained and legally authorised to provide integral medical (e.g. prescribing) and nursing care independently. Informal discussions among rheumatology nurses suggest a variation in roles, and tasks of SNs and NPs, and of care organisation in rheumatology practices. <h3>Objectives</h3> The objective of this study was to explore current roles and tasks of SNs and NPs, and care organisation in order to visualise potential variation. <h3>Methods</h3> A web-based questionnaire, based on literature [2] and existing task descriptions was disseminated among all members of the Dutch Nurses Association, unit Rheumatology (n=257). The questions were in closed-ended, multiple choice, likert-scales and open-ended format as appropriate. Data were analysed descriptively. Subgroup analyses were carried out for SNs and NPs. <h3>Results</h3> In total 84 nurses, 75 SNs and 9 NPs responded. Characteristics, roles and main tasks are presented in Table 1.The majority of the SNs, 96.4%, and 100% of the NPs work at the outpatient clinic, providing individual face-to-face consultations or telephone support. <h3>Conclusions</h3> Differences in roles, tasks and available time for consultations visualise variation in care organisation and in the content of rheumatology nursing care, also within the SN and NP group respectively. Further research on these differences is necessary but they show inequity of care for people with RMDs in the Netherlands and also suggests suboptimal use of nursing competencies. <h3>References</h3> van Eijk-Hustings Y, et al. EULAR recommendations for the role of the nurse in the management of chronic infl ammatory arthritis. Ann Rheum Dis. 2012;71:13–19. Ryan S, et al. Characterizing the clinical practice and professional behaviour of rheumatology nurse specialists: a pilot study. Musculoskelet. 2010;8(3):136–42. <h3>Acknowledgements</h3> Funded by Dutch Rheumatology Nurses Association, unit Rheumatology. <h3>Disclosure of Interest</h3> None declared
Effects of memory and sleep on functional status in cancer survivors.
Authors: Molly Geraghty, Shanice Cox, Eileen R Giglia, Ashley Jean-Pierre, Harisa Saphic, Michael Grandner, Pascal Jean-Pierre
Journal: Journal of Clinical Oncology (2015)

e20642 Background: Cognitive functioning (e.g., memory performance) is important to an individual’s functional abilities. Sleep impairments have implications for both cognitive function and sleep. However, studies on the relationships among sleep, functional status, and cognitive functioning (e.g., memory) in cancer survivors are lacking. In the present study, we assessed the relationships among memory, sleep, and functional status. Methods: We examined data from cancer survivors, 41-64 years, who completed the 2007-2008 NHANES. Sample size ranged from 265 to 504, based on responses addressing functional status limitation in 23 activities of daily functioning. Sleep duration was categorized as “Very Short” ( < 5 hours), “Short” (5-6 hours), “Normal” (7-8 hours), or “Long” ( ≥ 9 hours). Cognitive dysfunction was operationalized as reports of experiencing confusion/memory problems. Weighted logistic regression (LR) analyses predicted likelihood of reporting limitations according to sleep duration (reference=Normal). Effects of cognitive dysfunction were assessed in a separate LR model. We adjusted for age, sex, race/ethnicity, education level, BMI, overall health status, and depressed mood. Results: Very Short sleep was associated with greater likelihood of limitations in 8 out of 23 functional status variables (p < 0.001-0.02). Long sleep was associated with difficulties standing up (p < 0.001). Cognitive dysfunction mediated the relationships between Very Short sleep and chores/standing for a long time. The proportion of mediation was > 20% for relationships with chores/walking, and 10-19% for relationships with walking up 10 steps, getting in/out of bed, standing/sitting for a long time, going out. Conclusions: Sleep was statistically significantly associated with functional and work limitations. Cognitive dysfunction mediated the relationship between sleep and functional status in cancer survivors. These results may indicate a negative effect of cognitive problems on functional status in cancer survivors. Future studies are needed to systematically describe these findings.