tbuckley/cabot-search huggingface dataset:
Traitement endoscopique de la dysplasie de haut grade et de l’adénocarcinome superficiel du cardia développés sur endobrachyoesophage
Authors: JM Canard, A de Leusse, L Palazzo, C Cellier, R Jian
Journal: Endoscopy (2004)

Introduction: La mucosectomie endoscopique permet le traitement curatif de la dysplasie de haut grade (DHG) et de l’adénocarcinome superficiel (ADK) du cardia développés sur endobrachy-ésophage (EBO). Buts: évaluer le traitement endoscopique par mucosectomie de la DHG et de l’ADK du cardia sur EBO en terme de: faisabilité des techniques, résultats, complications et taux de récidive. Patients et Méthodes: De septembre 1997 à juillet 2003, 21 patients (13 H, âge moyen 73 ans) présentaient un total de 24 lésions: DHG (33%) et ADK superficiel (67%) sur EBO. Il s’agissait en majorité de lésion de taille inférieure à 20 mm (75%) toutes classées au maximum T1 en échoendoscopie haute standard (62%) ou T1sm2 en mini sonde (38%). Une injection sous muqueuse préalable à la mucosectomie n’a été faite que chez les derniers patients (n = 4). La mucosectomie était réalisée selon la technique d’aspiration section sur bague (46%) ou de traction section (29%) avec un appareil à double canal ou par une technique combinée (25%). La mucosectomie était complétée d’une destruction des résidus tumoraux et par l’éradication de l’EBO par APC. Un contrôle endoscopique était réalisé à 3 mois puis tous les 6 mois. Résultats: La résection muqueuse (par fragments = 11, en bloc = 13) était techniquement possible chez tous les patients. Le traitement endoscopique de la lésion était considéré macroscopiquement complet chez tous les patients. Une complication précoce à type de perforation a été observée chez 2 patients, traitée médicalement pour l’un et chirurgicalement pour l’autre. Aucune hémorragie secondaire nécessitant une reprise endoscopique ou une transfusion n’a été notée. Chez 5 patients, un saignement au cours de la mucosectomie nécessitant un traitement endoscopique n’a pas été pas considéré comme une complication. L’analyse histologique objectivait une lésion infiltrante chez 1 patient. Après résection curative (n = 20, 95%) et après un suivi endoscopique médian de 23 mois (extrêmes: 3–42 mois), une récidive était notée chez 1 patient (5%). Conclusion: Le traitement endoscopique (mucosectomie et APC) de la DHG et de ADK superficiel du cardia sur EBO est un traitement curatif efficace compte tenu de l’excellent taux de résécabilité et du faible risque de récidive. La complication de perforation chez 2 patients a été notée dans la phase initiale de l’étude. Enfin, l’analyse histologique de l’envahissement tumoral permet de justifier un éventuel traitement complémentaire (chirurgie, radio chimiothérapie).
Large scale genomic reorganization of topological domains at the HoxD locus
Authors: Pierre J. Fabre, Marion Leleu, Benjamin H. Mormann, Lucille Lopez-Delisle, Daan Noordermeer, Leonardo Beccari, Denis Duboule
Journal: Genome biology (2017)

The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD genes in developing digits is controlled by regulatory elements located in the centromeric TAD (C-DOM) through long-range contacts. To assess the structure–function relationships underlying such interactions, we measured compaction levels and TAD discreteness using a combination of chromosome conformation capture (4C-seq) and DNA FISH. We assessed the robustness of the TAD architecture by using a series of genomic deletions and inversions that impact the integrity of this chromatin domain and that remodel long-range contacts. We report multi-partite associations between HoxD genes and up to three enhancers. We find that the loss of native chromatin topology leads to the remodeling of TAD structure following distinct parameters. Our results reveal that the recomposition of TAD architectures after large genomic re-arrangements is dependent on a boundary-selection mechanism in which CTCF mediates the gating of long-range contacts in combination with genomic distance and sequence specificity. Accordingly, the building of a recomposed TAD at this locus depends on distinct functional and constitutive parameters.
Are vitiligo treatments cost‐effective? A systematic review
Authors: E. McManus, T. Sach, N.J. Levell
Journal: British Journal of Dermatology (2017)

There is currently no review of the economic evidence within vitiligo. What does this study add?-This study highlights the lack of economic evidence within vitiligo, particularly surrounding the cost-effectiveness of currently prescribed treatments.-It is important that this research paucity is addressed.Vitiligo is characterised by well demarcated, cutaneous, macular depigmentation, with worldwide prevalence estimated to be between 0.2-1.8%[1].Vitiligo treatments aim to encourage repigmentation and include topical corticosteroids, calcineurin inhibitors and NB-UVB phototherapy.Camouflage can also be prescribed to help mask the appearance of vitiligo, although this is frequently only prescribed for the face.
BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI
Authors: Satya K. Kota, Elizabeth Pernicone, David E. Leaf, Isaac E. Stillman, Sushrut S. Waikar, Savithri Balasubramanian Kota
Journal: Journal of the American Society of Nephrology (2017)

AKI is a major cause of morbidity and mortality and an important contributor to the development and progression of CKD. Molecular biomarkers that improve the detection and prognostication of AKI are therefore required. We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2), also known as parotid secretory protein, which we identified via a multiplex quantitative proteomics screen of acutely injured murine kidneys. In physiologic conditions, BPIFA2 is expressed specifically in the parotid glands and is abundant in salivary secretions. In our study, AKI induced Bpifa2 expression in the kidneys of mice within 3 hours. Furthermore, we detected BPIFA2 protein in plasma and urine in these models as early as 6 hours after injury. However, renal injury did not induce the expression of Bpifa2 in mice lacking Nur77, an immediate early gene expressed in the kidneys during AKI. Notably, patients with AKI had higher blood and urine levels of BPIFA2 than did healthy individuals. Together, our results reveal that BPIFA2 is a potential early biomarker of AKI.
Global Prospective Cohort Study of Factors Associated with Venous Thromboembolism in Patients with Lung Cancer Receiving Cancer Therapy
Authors: Nicole M. Kuderer, Marek S. Poniewierski, Eva Culakova, Gary H. Lyman, Alok A. Khorana, Ingrid Pabinger, Giancarlo Agnelli, Howard A. Liebman, Eric Vicaut, Guy Meyer, Frances A. Shepherd
Journal: Blood (2016)
Serum Iron Protects from Renal Postischemic Injury
Authors: Céline Vaugier, Mariane T. Amano, Jonathan M. Chemouny, Michael Dussiot, Claire Berrou, Marie Matignon, Sanae Ben Mkaddem, Pamella H.M. Wang, Aurélie Fricot, Thiago T. Maciel, Damien Grapton, Jacques R.R. Mathieu, Carole Beaumont, Marie-Noëlle Peraldi, Carole Peyssonnaux, Laurent Mesnard, Eric Daugas, François Vrtovsnik, Renato C. Monteiro, Olivier Hermine, Yelena Z. Ginzburg, Marc Benhamou, Niels O.S. Camara, Martin Flamant, Ivan C. Moura
Journal: Journal of the American Society of Nephrology (2017)

Renal transplants remain a medical challenge, because the parameters governing allograft outcome are incompletely identified. Here, we investigated the role of serum iron in the sterile inflammation that follows kidney ischemia-reperfusion injury. In a retrospective cohort study of renal allograft recipients (n=169), increased baseline levels of serum ferritin reliably predicted a positive outcome for allografts, particularly in elderly patients. In mice, systemic iron overload protected against renal ischemia-reperfusion injury-associated sterile inflammation. Furthermore, chronic iron injection in mice prevented macrophage recruitment after inflammatory stimuli. Macrophages cultured in high-iron conditions had reduced responses to Toll-like receptor-2, -3, and -4 agonists, which associated with decreased reactive oxygen species production, increased nuclear localization of the NRF2 transcription factor, increased expression of the NRF2-related antioxidant response genes, and limited NF-κB and proinflammatory signaling. In macrophage-depleted animals, the infusion of macrophages cultured in high-iron conditions did not reconstitute AKI after ischemia-reperfusion, whereas macrophages cultured in physiologic iron conditions did. These findings identify serum iron as a critical protective factor in renal allograft outcome. Increasing serum iron levels in patients may thus improve prognosis of renal transplants.
More than a decade follow-up in patients with severe or difficult-to-treat asthma: The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) II
Authors: Bradley E. Chipps, Tmirah Haselkorn, Brandee Paknis, Benjamin Ortiz, Eugene R. Bleecker, Farid Kianifard, Aimee J. Foreman, Stanley J. Szefler, Robert S. Zeiger
Journal: Journal of Allergy and Clinical Immunology (2017)
05.02 Differentiating patient responses in rheumatoid arthritis – systems analysis of key molecular networks
Authors: Kate Killick, Walter Kolch, Des Higgins, Trudy McGarry, Carl Orr, Alice M Walsh, Sunil Nagpal, Ursula Fearon, Douglas J Veale
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Rheumatoid Arthritis (RA) is a progressive autoimmune disease characterised by synovial hyperplasia resulting in destruction of adjacent articular cartilage and bone. While new therapeutic strategies over the last 15 years represent an advance in treatment, a significant proportion of patients do not respond, have sub-optimal responses or suffer adverse effects. Therefore identification of baseline markers that can predict clinical response along with new therapies will allow for better treatment stratification for RA patients. <h3>Materials and methods</h3> Peripheral blood mononuclear cells were obtained from patients with RA at baseline. Patients were followed clinically and categorised into responders (n=10) vs non responders (n=9) based on clinical disease outcome. mRNA was isolated from PBMC and RNAseq performed. Ingenuity<sup>®</sup> Pathway Analysis (IPA) software was used to examine gene enrichment within differentially expressed genes. Interaction network analysis and identification of key hub nodes was performed using InnateDB and Cytoscape. <h3>Results</h3> Initial analysis identified differential expression of 155 genes between responders vs non responders. IPA pathway and Gene Ontology analysis demonstrated these were associated with several relevant pathways eg, antigen presentation, with top GO functions related to autoimmune disease, specifically RA. Differential gene expression was associated with leukocyte trafficking and alterations in extracellular matrix components, which was further confirmed by additional IPA network analysis of the RA dataset, identifying a key Inflammatory response/cell movement network. Potential upstream target regulators of these pathways incude <i>TREM-1</i>, <i>IL-17A</i> and <i>HIF1A</i>, which are known to be significantly involved in regulating synovial proliferation in the RA joint. Finally an interaction network analysis identifed <i>CXCL5</i>, <i>ADAMTSL4</i>, <i>CSTB</i>, <i>PPBP</i>, <i>CBLB</i>, <i>ELANE</i>, <i>PTGDS</i>, <i>CXCL2</i>, <i>SP1</i>, <i>CXCL1</i> as key hub genes preferentially connected to the 155 differentially expressed genes. <h3>Conclusion</h3> These data demonstrate differential gene expression and gene networks in responders vs non responder patients, specifically associated with leukocyte trafficking and synovial extravasation. However, given the small sample size, these results need to be validated in independent cohorts. Understanding differences in responder vs nonresponder patients at baseline represents an opportunity to both better understand the mechanisms of current drugs and investigate new therapeutic targets in those who don't respond to current treatment.
IS MOVEMENT OF LOWER EXTREMITY DURING SPORTS MANEUVERS SIMILAR?
Authors: Yukio Urabe, Moriyama Nobuaki, Morita Miho, Suzuki Yuta, Maeda Noriaki
Journal: British Journal of Sports Medicine (2017)

Background Anterior cruciate ligament (ACL) injury occurs in left leg more frequently than right leg. Authors have developed new screening test using a situationally bicycle to detecting malalignment represented by a toe-out which may cause ACL injuries during sports. Objective To measure foot abduction (toe-out) angle during pedalling movement in collegiate athletes and to examine whether pedalling movement can detect by comparing with those during running. Design Repeated measures design. Setting Laboratory setting. Patients (or Participants) A total of 120 collegiate basketball athletes with no orthopaedic diagnosis in lower extremities participated in this study. This study was approved by the institutional review board of Graduate School of Biomedical and Health Sciences, Hiroshima University (ID:1335). Interventions (or Assessment of Risk Factors) Pedalling movement and running. Main Outcome Measurements Foot abduction (toe-out) angle during pedalling was calculated based on video images. To compare foot abduction angle between during pedaling and straight running and circle running (clockwise and counterclockwise) was also measured. Results Higher foot abduction angle was observed in right feet (5.7°±3.5°) compared with those in left feet (4.5°±2.9°) during pedalling (p&lt;0.05). The same difference was observed in straight running (p&lt;0.05). Especially, during circle running, foot adduction angle of outside feet was larger compared with inside feet (p&lt;0.05). In addition, the angle of right feel during counterclockwise circle running was larger compared with that of left feet during clockwise running (p&lt;0.05). Conclusions The result of this study showed that foot abduction angle during pedalling movement was similar to that during running. Foot abduction angle of right was larger compared with that of left. This tendency was remarkable during circle ruining. Although, this result is contradict to the fact that ACL injury during sports occurs more frequently in left legs compared with right legs, it deserves further discussion.
Whole-genome sequencing of Campylobacter jejuni isolated from Danish routine human stool samples reveals surprising degree of clustering
Authors: K.G. Joensen, K.G. Kuhn, L. Müller, J.T. Björkman, M. Torpdahl, J. Engberg, H.M. Holt, H.L. Nielsen, A.M. Petersen, S. Ethelberg, E.M. Nielsen
Journal: Clinical Microbiology and Infection (2017)
Abstract 12657: Transcatheter Pulmonary Valve Implantation - Results in 25 Patients
Authors: Elzbieta K Biernacka, Marcin Demkow, Mateusz Spiewak, Miroslaw Kowalski, Jolanta Misko, Piotr Hoffman, Witold Ruzyllo
Journal: Circulation (2011)

Purpose: To assess the results of transcatheter pulmonary valve implantation (TPVI) in pts with pulmonary conduits and patched right ventricular outflow tract (RVOT). Methods: TPVI with routine pre...
ASSOCIATION BETWEEN FRONTAL PLANE KNEE CONTROL AND ACUTE LOWER EXTREMITY INJURIES
Authors: Anu Räisänen, Kati Pasanen, Tron Krosshaug, Pekka Kannus, Tommi Vasankari, Jari Parkkari
Journal: British Journal of Sports Medicine (2017)

Background Single-leg squat (SLS) is a clinical tool used to assess knee control. Previous studies have proposed that knee valgus motion in the SLS could be related to injury risk, but this association has not been previously examined. Objective The objective of this study was to investigate the association between acute lower extremity injuries and frontal plane knee control in young athletes. Design This study is part of a prospective cohort study (PROFITS-study). As part of the baseline test battery, we measured frontal plane projection angles during SLS. We also measured the athlete's height and weight, and the athletes filled out a questionnaire describing their time-loss injuries during the past 12 months. We registered new time-loss injuries in the following 12 months on a weekly basis. Only athletes free from lower extremity injuries during the 12 months prior to baseline were included in the analyses. Setting Research institute, youth sports. Participants Ten local basketball and ten local floorball teams were invited to the study. Out of these, 9 basketball and 9 floorball teams agreed to participate. Only athletes who were 21 years or younger and were free from injury during baseline were eligible. Complete data were obtained from 306 athletes. Assessment of Risk Factors A generalized linear mixed model was used to analyse the potential risk factors. Main Outcome Measurements Acute time loss lower extremity injuries sustained during the 12 month period after baseline. Results Displaying a frontal plane projection angle greater than 1 standard deviation above the mean (&gt;23.8°) in the SLS was associated with a higher risk of lower extremity injuries (OR 5.57, 95% CI 1.61–19.32) and ankle injuries (OR 2.37, 95% CI 1.13–4.98). Conclusions Based on this study, athletes who display large frontal plane projection angles during the SLS have an elevated risk of lower extremity injuries.
Neurotensin Receptor 1 Antagonist SR48692 Improves Response to Carboplatin by Enhancing Apoptosis and Inhibiting Drug Efflux in Ovarian Cancer
Authors: Jin Liu, Mikaël Agopiantz, Joël Poupon, Zherui Wu, Pierre-Alexandre Just, Bruno Borghese, Evelyne Ségal-Bendirdjian, Guillaume Gauchotte, Anne Gompel, Patricia Forgez
Journal: Clinical Cancer Research (2017)

Purpose: The high affinity receptor 1 (NTSR1) and its agonist, neurotensin (NTS), are correlated with tumor cell aggressiveness in most solid tumors. As chemoresistance and tumor aggressiveness are often related, we decided to study the role of the NTSR1 complex within platinum-based chemotherapy responses. In an ovarian model, we studied carboplatin because it is the main standard of care for ovarian cancer.Experimental Design: Experimental tumors and in vitro studies were performed using SKOV3 and A2780 cells treated with carboplatin, with or without a very specific NTSR1 antagonist, SR48692. We measured the effects of these treatments on cell apoptosis and apoptosis-related proteins, platinum accumulation in the cell and nucleus, and the expression and localization of platinum transporters. NTS and NTSR1 labeling was measured in patients with ovarian cancer.Results: SR48692 enhanced the response to carboplatin in ovarian cancer cells and experimental tumors. When SR48692 is combined with carboplatin, we noted a major improvement of platinum-induced DNA damage and cell death, as well as a decrease in tumor growth. The relationship of these results to clinical studies was made by the detection of NTS and NTSR1 in 72% and 74% of ovarian cancer, respectively. Furthermore, in a large series of high-grade ovarian cancer, NTSR1 mRNA was shown to correlate with higher stages and platinum resistance.Conclusions: This study strongly suggests that the addition of NTSR1 inhibitor in combination with platinum salt-based therapy will improve the response to the drug. Clin Cancer Res; 23(21); 6516-28. ©2017 AACR.
マクロ多孔性足場からのデキサメタゾンの局所放出は抗炎症性M2マクロファージの促進による島移植生着を促進する【Powered by NICT】
Authors: Jiang Kaiyuan, D Weaver Jessica, Li Yangjunyi, Chen Xiongjian, Liang Jiapu, L Stabler Cherie
Journal: Biomaterials (2017)
Abstract 14223: Atrial Fibrillation, Clinical Outcomes, and Post-discharge Natriuretic Peptide Trajectory Among Patients Hospitalized for Heart Failure: Findings From the ASTRONAUT Trial
Authors: Stephen J Greene, Gregg C Fonarow, Haris Subacius, Aldo P Maggioni, Faiez Zannad, Scott D Solomon, Eldrin F Lewis, Michael Böhm, Mihai Gheorghiade
Journal: Circulation (2015)

Introduction: Heart failure (HF) clinical trials have used change in NT-proBNP as a surrogate endpoint, but the influence of atrial fibrillation/ flutter (AFF) on this endpoint is unclear. We investigated the association of AFF with change in NT-proBNP and clinical outcomes following HF hospitalization. Methods: Characteristics and outcomes of 1,358 patients from the ASTRONAUT trial were compared by presence/ absence of AFF on baseline ECG. Patients with history of AFF but without AFF on ECG were excluded. Full factorial repeated measures design using AFF and study randomization was used to predict NT-proBNP changes from baseline to 1, 6, and 12 months. Survival analysis was used to examine the correlation between AFF and outcomes. Results: Patient characteristics and outcomes are displayed in the Table. Among placebo patients, AFF was associated with higher NT-proBNP level at all time points, but larger reductions from baseline levels (p for interaction &lt;0.01). These differences became non-significant after accounting for other clinical characteristics. The ability of aliskiren to lower NT-proBNP over time differed by AFF status (p for interaction &lt;0.01, Figure). After adjustment for patient characteristics, AFF was not associated with cardiovascular mortality/ HF hospitalization or all-cause death at 12 months (all p≥0.15). Conclusions: Absolute levels and change from baseline in NT-proBNP over time differ in HF patients with and without AFF. The ability of a study drug to lower NT-proBNP may depend on the AFF prevalence in the population. AFF was not independently associated with clinical outcomes in this cohort.
A STUDY TO EVALUATE THE EFFECTS OF A NEUROMUSCULAR INJURY PREVENTION PROGRAMME (GAA 15) IN ADOLESCENT MALES PARTICIPATING IN HURLING
Authors: Sean Kelly, Clare Lodge, Paul Miley
Journal: British Journal of Sports Medicine (2017)

Background Adolescents involvement in organised sport has never been more popular with post primary school students in Ireland, however, this increased level of activity has reportedly caused concern regarding the potential risk and severity of sporting injuries. Objective The aim of the current investigation was to assess and critically analyse the application and implementation of a neuromuscular injury prevention programme (GAA 15) in adolescent males participating in hurling at post primary school level. Design Randomised control trial. Setting Second level post primary schools youth sport. Patients (or Participants) 518 male subjects aged 13–18.5 years were recruited from fourteen post primary schools, seven schools participated in the intervention group and seven in the control group. Interventions (or Assessment of Risk Factors) The intervention group implemented an injury prevention warm-up programme, namely the GAA 15, before every training session and matches. The control group adopted their normal warm-up behaviour prior to matches and training. Main Outcome Measurements Epidemiological injury rate ratio (IRR) and injury proportion (IP) was compared between the two groups. Results Hurling training injury rates of 16.51/1000 hrs. (95% CI: 9.9–23.1) and 9.16/1000 hrs. (95% CI: 5.5–12.8) were recorded for the control and intervention groups respectively. Match injury rates of 36.32/1000 hrs. (95% CI: 21.1–51.5) and 25.62/1000 hrs. (95% CI: 16.9–34.4) were reported for the control and intervention groups. Lower extremity injuries made up 75% of all injuries recorded with the hamstring being the most frequently injured body part. Hurling training lower extremity injuries were reduced by 45% and match injuries by 29% in the intervention group when compared to the control group. Conclusions Following this investigation, it can be concluded that positive outcomes can be achieved from the implementation of a neuromuscular injury prevention warm-up, namely the GAA 15, to reduce lower extremity injuries in adolescent males participating in hurling.