tbuckley/cabot-search huggingface dataset:
Low-Calorie Vegetarian Versus Mediterranean Diets for Reducing Body Weight and Improving Cardiovascular Risk Profile
Authors: Francesco Sofi, Monica Dinu, Giuditta Pagliai, Francesca Cesari, Anna Maria Gori, Alice Sereni, Matteo Becatti, Claudia Fiorillo, Rossella Marcucci, Alessandro Casini
Journal: Circulation (2018)

Only a few randomized dietary intervention studies that investigated the effects of lacto-ovo vegetarian diet (Vd) in clinically healthy omnivorous subjects are available.We randomly assigned to overweight omnivores with a low-to-moderate cardiovascular risk profile a low-calorie Vd compared with a low-calorie Mediterranean diet (MD), each lasting 3 months, with a crossover design. The primary outcome was the difference in body weight, body mass index, and fat mass changes between the 2 groups. Secondary outcomes were differences in circulating cardiovascular disease risk parameters changes between the 2 groups.One hundred eighteen subjects (mean age: 51.1 years, females: 78%) were enrolled. The total participation rate at the end of the study was 84.7%. No differences between the 2 diets in body weight were observed, as reported by similar and significant reductions obtained by both Vd (-1.88 kg) and MD (-1.77 kg). Similar results were observed for body mass index and fat mass. In contrast, significant differences between the 2 interventions were obtained for low-density lipoprotein cholesterol, triglycerides, and vitamin B12 levels. The difference between the Vd and MD groups, in terms of end-of-diet values, was recorded at 9.10 mg/dL for low-density lipoprotein cholesterol (P=0.01), 12.70 mg/dL for triglycerides (P<0.01), and 32.32 pg/mL for vitamin B12 (P<0.01). Finally, no significant difference was found between Vd and MD interventions in oxidative stress markers and inflammatory cytokines, except for interleukin-17, which improved only in the MD group. Forty-six participants during the Vd period and 35 during the MD period reached the target values for ≥1 cardiovascular risk factor.Both Vd and MD were effective in reducing body weight, body mass index, and fat mass, with no significant differences between them. However, Vd was more effective in reducing low-density lipoprotein cholesterol levels, whereas MD led to a greater reduction in triglyceride levels.URL: https://www.clinicaltrials.gov. Unique identifier: NCT02641834.
Editor’s Choice: Left in limbo
Authors: Tom Moberly
Journal: BMJ (2015)

For each of the past five years, the number of UK medical students applying to become doctors has exceeded the number of training places available to them. As a result, hundreds of medical students are left with uncertain futures. The BMA believes that the current situation, and the stress it places on medical students left in limbo in this way, is “deeply concerning.” This week …
How to appraise medical apps: a guideline based framework
Authors: Misha M Verkerk, David Bargiela
Journal: BMJ (2013)

It is important to know whether a medical app you are thinking of using is safe and suitable for its intended purpose, but there are no EU regulations on this. <b>Misha M Verkerk </b>and <b>David Bargiela</b> look at how recent US guidelines can help users and developers
Evaluating Thrombocytopenia During Heparin Therapy
Authors: Yu-Min Shen, Heather Wolfe, Stephen Barman
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diploma in Clinical Psychiatry (DCP) conducted by the Royal College of Physicians of Ireland
Authors: Gaurav Mehta
Journal: BMJ (2007)

Although the purpose of the diploma exam is to recognise competence in psychiatric care for doctors working in primary care, it is also suitable for psychiatry trainees who are interested in taking the exam for membership of the Royal College of Psychiatrists (MRCPsych).

I did the diploma in October 2005. I was in my second year of basic specialist training as a senior house officer in psychiatry.

I did it as practice for my part one MRCPsych exam and to gain an extra qualification.

I studied textbooks seriously for three months and did lots of multiple choice questions (MCQs). …
DIAGNOSTIC VALUE OF TRANSLUMINAL ATTENUATION GRADIENT FOR THE PRESENCE OF ISCHEMIA AS DEFINED BY FRACTIONAL FLOW RESERVE AND QUANTITATIVE POSITRON EMISSION TOMOGRAPHY
Authors: Michiel Bom, Roel Driessen, Wijnand Stuijfzand, Pieter Raijmakers, Cornelis Van Kuijk, Adriaan Lammertsma, Albert van Rossum, Niels Van Royen, Juhani Knuuti, Maija Mäki, Koen Nieman, James K. Min, Jonathon Leipsic, Ibrahim Danad, Paul Knaapen
Journal: Journal of the American College of Cardiology (2018)
Metabolic Predictors of Incident Coronary Heart Disease in Women
Authors: Nina P. Paynter, Raji Balasubramanian, Franco Giulianini, Dong D. Wang, Lesley F. Tinker, Shuba Gopal, Amy A. Deik, Kevin Bullock, Kerry A. Pierce, Justin Scott, Miguel A. Martínez-González, Ramon Estruch, JoAnn E. Manson, Nancy R. Cook, Christine M. Albert, Clary B. Clish, Kathryn M. Rexrode
Journal: Circulation (2018)

Background: Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. Methods: We applied a liquid chromatography–tandem mass spectrometry metabolomics platform to measure 371 metabolites in a discovery set of postmenopausal women (472 incident CHD cases, 472 controls) with validation in an independent set of postmenopausal women (312 incident CHD cases, 315 controls). Results: Eight metabolites, primarily oxidized lipids, were significantly dysregulated in cases after the adjustment for matching and CHD risk factors in both the discovery and validation data sets. One oxidized phospholipid, C34:2 hydroxy-phosphatidylcholine, remained associated with CHD after further adjustment for other validated metabolites. Subjects with C34:2 hydroxy-phosphatidylcholine levels in the highest quartile had a 4.7-fold increase in CHD odds in comparison with the lowest quartile; C34:2 hydroxy-phosphatidylcholine also significantly improved the area under the curve ( P &lt;0.01) for CHD. The C34:2 hydroxy-phosphatidylcholine findings were replicated in a third replication data set of 980 men and women (230 cardiovascular events) with a stronger association observed in women. Conclusions: These data replicate known metabolite predictors, identify novel markers, and support the relationship between lipid oxidation and subsequent CHD.
Open University professional certificate in management
Authors: Simon Auty
Journal: BMJ (2006)

Credit: PHOTOS.COM



This is a very useful course for anyone interested in learning about management. There are many different management courses and some are more focused, for example, the health management course, and some are more generic like this course.

I did the course in 2002-2003.

In my job at that time I was involved in the development of a relatively new service and so was asked to attend many management oriented meetings such as steering groups and various boards. I did not really understand much of the management language being used and felt I needed more training in this area.

In addition I was working with different groups and teams and felt …
RECENT TEMPORAL TRENDS AND SEX DIFFERENCES IN BLEEDING COMPLICATIONS AFTER CORONARY INTERVENTION: A REPORT FROM THE NORTHERN NEW ENGLAND CARDIOVASCULAR DISEASE STUDY GROUP
Authors: Bina Ahmed, Thomas Ryan, Peter Ver Lee, James Flynn, Patrick Magnus, Harold Dauerman, Megan Coylewright, James Devries, Yi-Ling Huang, David Malenka
Journal: Journal of the American College of Cardiology (2018)
Revising our approach to conducting therapeutic clinical research in COPD
Authors: Gerard J. Criner
Journal: European Respiratory Journal (2018)

Chronic obstructive pulmonary disease (COPD) is a major worldwide cause of death, and a leading cause of chronic disability and driver of high healthcare expenditures [1]. Efficacy and effectiveness trials are needed to enable more effective treatment in COPD <http://ow.ly/da2o30hPPNW>
A COMPARISON OF ATRIAL FIBRILLATION MONITORING STRATEGIES IN PATIENTS AT HIGH RISK FOR ATRIAL FIBRILLATION AND STROKE: RESULTS FROM THE REVEAL AF STUDY
Authors: James A. Reiffel, Atul Verma, Peter Kowey, Jonathan Halperin, Bernard Gersh, Mitchell S.V. Elkind, Paul Ziegler, Lou Sherfesee, Rolf Wachter
Journal: Journal of the American College of Cardiology (2018)
Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life
Authors: Luiza K. Axelrud, Marcos L. Santoro, Daniel S. Pine, Fernanda Talarico, Ary Gadelha, Gisele G. Manfro, Pedro M. Pan, Andrea Jackowski, Felipe Picon, Elisa Brietzke, Rodrigo Grassi-Oliveira, Rodrigo A. Bressan, Eurípedes C. Miguel, Luis A. Rohde, Hakon Hakonarson, Zdenka Pausova, Sintia Belangero, Tomas Paus, Giovanni A. Salum
Journal: American Journal of Psychiatry (2018)

Objective: Alzheimer’s disease is a heritable neurodegenerative disorder in which early-life precursors may manifest in cognition and brain structure. The authors evaluate this possibility by examining, in youths, associations among polygenic risk score for Alzheimer’s disease, cognitive abilities, and hippocampal volume. Method: Participants were children 6–14 years of age in two Brazilian cities, constituting the discovery (N=364) and replication samples (N=352). As an additional replication, data from a Canadian sample (N=1,029), with distinct tasks, MRI protocol, and genetic risk, were included. Cognitive tests quantified memory and executive function. Reading and writing abilities were assessed by standardized tests. Hippocampal volumes were derived from the Multiple Automatically Generated Templates (MAGeT) multi-atlas segmentation brain algorithm. Genetic risk for Alzheimer’s disease was quantified using summary statistics from the International Genomics of Alzheimer’s Project. Results: Analyses showed that for the Brazilian discovery sample, each one-unit increase in z-score for Alzheimer’s polygenic risk score significantly predicted a 0.185 decrement in z-score for immediate recall and a 0.282 decrement for delayed recall. Findings were similar for the Brazilian replication sample (immediate and delayed recall, β=−0.259 and β=−0.232, both significant). Quantile regressions showed lower hippocampal volumes bilaterally for individuals with high polygenic risk scores. Associations fell short of significance for the Canadian sample. Conclusions: Genetic risk for Alzheimer’s disease may affect early-life cognition and hippocampal volumes, as shown in two independent samples. These data support previous evidence that some forms of late-life dementia may represent developmental conditions with roots in childhood. This result may vary depending on a sample’s genetic risk and may be specific to some types of memory tasks.
Don’t impose new contract on junior doctors, royal college urges Hunt
Authors: Abi Rimmer
Journal: BMJ (2016)

The president of the Royal College of Paediatrics and Child Health has written to the health secretary to urge him to rethink his decision to impose a new contract on junior doctors.

Neena Modi wrote to Jeremy Hunt on 14 July, to congratulate him on his re-appointment as secretary of state for health. In the letter she said she was also writing …
A phase 3b safety study of fixed-dose durvalumab + tremelimumab or durvalumab monotherapy in advanced solid malignancies (STRONG): Urothelial and non-urothelial urinary tract carcinoma module A.
Authors: Guru Sonpavde, Solange Peters, Luke T. Nordquist, Terufumi Kato, Paulo Andre Miranda, Qin Wang, Mark A. Socinski
Journal: Journal of Clinical Oncology (2018)

TPS538 Background: Despite initial high response rates to current SoC first-line chemotherapy, most patients with locally advanced or metastatic urothelial carcinoma (UC) eventually experience disease progression. With no defined SoC second-line therapies, prognosis remains poor. Durvalumab is a selective, high affinity, engineered human IgG1 mAb that blocks programmed cell death ligand-1 binding to programmed cell death-1 and CD80. Most current Phase 3 trials of durvalumab were initiated using weight-based dosing (mg/kg) regimens. STRONG (NCT03084471), a Phase 3b safety study of durvalumab alone or in combination with the anti-CTLA-4 agent tremelimumab is being conducted to expand understanding of the safety of fixed dosing in patients with advanced solid tumors. Module A of the study is enrolling patients with UC and non-urothelial carcinoma of the urinary tract (any histology) for treatment with durvalumab in the second-line setting post-chemotherapy. Other study modules will include durvalumab + tremelimumab combination arms. Methods: This is an open-label, multicenter study. Module A will enroll approximately 1200 patients to receive durvalumab monotherapy 1,500 mg i.v. q4w until disease progression or unacceptable toxicity. The study opened for enrolment on 17 April 2017 and is expected to be completed within 5 years. Patients must have histologically or cytologically confirmed disease that has progressed during or after nonplatinum or platinum-based chemotherapy either for metastatic disease or progressive disease less than 12 months after adjuvant or neo-adjuvant chemotherapy, and ECOG performance status 0–2. The primary objective is to assess the safety of durvalumab in terms of incidence, severity, nature, seriousness, intervention, outcome and causality (including immune-relatedness) of adverse events of special interest (AESIs). Secondary objectives include additional assessment of safety and tolerability, the frequency of treatment interruption and discontinuation, and overall survival. Clinical trial information: NCT03084471.
INCREMENTAL VALUE OF EXTRACELLULAR VOLUME ASSESSMENT BY CARDIOVASCULAR MAGNETIC RESONANCE IMAGING IN RISK STRATIFYING PATIENTS WITH SUSPECTED MYOCARDITIS
Authors: Christoph Gräni, Loïc Bière, Christian Eichhorn, Kyoichi Kaneko, Vikram Agarwal, Ayaz Aghayev, Michael Steigner, Ron Blankstein, Michael Jerosch-Herold, Raymond Kwong
Journal: Journal of the American College of Cardiology (2018)
I am an international A level student hoping to study medicine at Oxford. The website says that I would have to attend an initial interview. What are the tutors looking for in an ideal candidate and how can I prepare?
Authors: Brian Angus
Journal: BMJ (2005)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone (www.bmjcareers.com/advicezone) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site.
大動脈バンディングの結果、マウスにおいて心肥大と心機能不全を阻害する選択的エストロジェン受容体モジュレータ・ラロキシフェン
Authors: Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Minamino T, Asakura M, Kim J, Liao Y, Asano Y, Shintani Y, Okada K, Fujita M, Hirata A, Tsukamoto O, Hori M, Kitakaze M
Journal: Journal of the American College of Cardiology (2003)
Mitral Valve Prolapse
Authors: T. Sloane Guy, Arthur C. Hill
Journal: Annual Review of Medicine (2012)

Mitral valve prolapse is defined as abnormal bulging of the mitral valve leaflets into the left atrium during ventricular systole. Mitral valve prolapse is a common condition that is a risk factor for mitral regurgitation, congestive heart failure, arrhythmia, and endocarditis. Myxomatous degeneration is the most common cause of mitral prolapse in the United States and Europe, and progression of myxomatous mitral prolapse is the most common cause of mitral regurgitation that requires surgical treatment. Myxomatous degeneration appears to have genetic etiology. The genetics of myxomatous degeneration is complex and not fully worked out; it appears to be heterogeneous with multi-gene, multi-chromosomal autosomal dominance with incomplete penetrance. The molecular disorder of myxomatous degeneration appears to consist of a connective tissue disorder with altered extracellular matrix status and involves the action of matrix metalloproteinase, cysteine endoproteases, and tenomodulin. Treatment of mitral prolapse with regurgitation is complex, and the technological advances that are currently in development will be challenging and controversial.
A medic and TV presenter
Authors: Salma Naheed
Journal: BMJ (2006)

Some people might know David Bull as a panellist on Channel 59s <i>The Wright Stuff</i>, others from his days at <i>Newsround</i>, <i>Richard and Judy</i>, or <i>Watchdog</i>. After qualifying as a doctor, David Bull sought a career in television. He tells <i>BMJ Careers</i> about getting there, as well as his career9s highs and lows
Australian exam “shambles” forces registrars into resits
Authors: Paul Smith
Journal: BMJ (2018)

Over 1000 registrars will have to retake their medical exams after an IT meltdown forced the Royal Australasian College of Physicians to abort its online test.

It was the first time the college had used computers for its Written Divisional exam, which registrars must pass to progress to advanced training.

The exam was held at test centres in 16 cities in Australia and New Zealand on 19 February. But an “unknown technical fault” prevented some candidates from logging back on after the lunch break.

One doctor, who did not want to be named, said that an error message flashed up on her screen as she finished the first part of the exam. “They couldn’t tell me what …
Beginnings and endings⇓
Authors: Nicola Sharp
Journal: BMJ (2004)

“I've made a big mistake this time.” Douglas stood on Penelope's front door step.

Penelope held on to her bump. Christopher clung to her legs.

“I said I've mucked up again,” said Douglas.

“I heard you,” said Penelope.

“I took a job as a hospital manager and it all went wrong,” said Douglas.

“What did you expect?” asked Penelope.

“You always give me good advice,” said Douglas.

“If I had any good advice, I'd use it myself,” said Penelope. She clasped her bump. “Ooooeeeurgh.”

“Are you all right?” asked Douglas.

“Just go away.”

“But are you in labour?”

“I'm only 29 weeks.”

\* * *|

“I've been looking at some dates.” Hubert thumbed through his desk diary.

“We must not be seen together,” said Martha.

“But David saw us together last week.”

“It mustn't happen again.”

“And I've told Ellen I want a divorce.”

“Why?”

“Because we're going to get married.”

“I'm married to David.”

“We will get married next summer, when our divorces have come through. I've been looking at possible dates for our wedding.”

“I'm not going to marry you.”

“I suppose we could live together.”

“No.”

“I can't live without you.”

“You will have to. After David saw us together I realised what …
FEASIBILITY OF TRANSCAVAL ACCESS FOR THE DELIVERY OF MECHANICAL CIRCULATORY SUPPORT IN CARDIOGENIC SHOCK
Authors: Majed Afana, Mahmoud Altawil, Mir Basir, Mohammad Alqarqaz, Khaldoon Alaswad, Marvin Eng, William W. O’Neill, Robert Lederman, Adam Greenbaum
Journal: Journal of the American College of Cardiology (2018)
Guidelines for Adult Stroke Rehabilitation and Recovery
Authors: Michelle Gittler, Andrew M. Davis
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
I am thinking of working as a cruise doctor. Could this adversely affect my chances of specialist training and career progression?
Authors: Alon Duby
Journal: BMJ (2005)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone (www.bmjcareers.com/advicezone) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site.
PREDICTORS OF SYSTOLIC HEART FAILURE AND MORTALITY FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION: A SINGLE-CENTER COHORT
Authors: Tanya Doctorian, Hyungjin Kim, Deepika Narasimha, Tigran Khachatryan, Amar Desai, Dennys Estevez, Kenneth Jutzy, Anthony A. Hilliard, Islam Abudayyeh, Liset Stoletniy, Pedro Baron, Antoine Sakr
Journal: Journal of the American College of Cardiology (2018)