Comparison of Five Major Guidelines for Statin Use in Primary Prevention
Authors: Martin Bødtker Mortensen, Børge Nordestgaard
Journal: Annals of Internal Medicine (2018)

Letters3 July 2018Comparison of Five Major Guidelines for Statin Use in Primary PreventionMartin Bødtker Mortensen, MD, PhD and Børge Nordestgaard, MD, DMScMartin Bødtker Mortensen, MD, PhDHerlev and Gentofte Hospital and Copenhagen University Hospital, Herlev, Denmark (M.B.M., B.N.) and Børge Nordestgaard, MD, DMScHerlev and Gentofte Hospital and Copenhagen University Hospital, Herlev, Denmark (M.B.M., B.N.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0182 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Drs. Lindblad and Korownyk that initiation of statin therapy for primary prevention of ASCVD should be based on shared decision making between the patient and the physician, carefully taking into account potential benefits, harms, and patient preferences (1). We are aware that, after such discussion, some patients will choose not to start statin therapy despite being eligible according to guideline recommendations.The aim of our study was to directly compare recommendations for statin eligibility from 5 major international statin guidelines. We show that these recommendations differ markedly, with major consequences on the number of persons ...References1. Martin SS, Sperling LS, Blaha MJ, Wilson PWF, Gluckman TJ, Blumenthal RS, et al. Clinician-patient risk discussion for atherosclerotic cardiovascular disease prevention: importance to implementation of the 2013 ACC/AHA guidelines. J Am Coll Cardiol. 2015;65:1361-8. [PMID: 25835448] doi:10.1016/j.jacc.2015.01.043 CrossrefMedlineGoogle Scholar2. Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2017;38:2459-72. [PMID: 28444290] doi:10.1093/eurheartj/ehx144 CrossrefMedlineGoogle Scholar3. Mortensen MB, Falk E. Limitations of the SCORE-guided European guidelines on cardiovascular disease prevention. Eur Heart J. 2017;38:2259-63. [PMID: 27941016] doi:10.1093/eurheartj/ehw568 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Herlev and Gentofte Hospital and Copenhagen University Hospital, Herlev, Denmark (M.B.M., B.N.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-0681. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComparison of Five Major Guidelines for Statin Use in Primary Prevention in a Contemporary General Population Martin Bødtker Mortensen and Børge Grønne Nordestgaard Comparison of Five Major Guidelines for Statin Use in Primary Prevention Adrienne J. Lindblad and Christina Korownyk Comparison of Five Major Guidelines for Statin Use in Primary Prevention Philippe Giral Metrics Cited byThe burden of cholesterol accumulation through the lifespan: why pharmacological intervention should start earlier to go further?Statins for Primary Prevention in the ElderlyLipid-Lowering Therapy for Primary Cardiovascular Prevention in Older Adults. Consensus Statement of the Russian Association of Gerontologists and Geriatricians, National Society on Atherosclerosis, Russian Society of Cardiology, Association of Clinical PharmacologistsStatins for Primary Prevention in Those Aged 70 Years and Older: A Critical Review of Recent Cholesterol Guidelines 3 July 2018Volume 169, Issue 1Page: 67-68KeywordsAtherosclerotic cardiovascular diseaseConflicts of interestDecision makingDisclosureLow density lipoproteinMolecular epidemiologyMortalityRandomized trialsStatinsTreatment guidelines ePublished: 3 July 2018 Issue Published: 3 July 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...