tbuckley/cabot-search huggingface dataset:
Abstract 024: Metabolomics and Incident Hypertension in African Americans from the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Yan Zheng, Bing Yu, Danny Alexander, Thomas H Mosley, Gerardo Heiss, Jennifer A Nettleton, Eric Boerwinkle
Journal: Circulation (2013)

Introduction: Development of hypertension is influenced by genes, environmental effects and their interactions, and the human metabolome is a measurable manifestation of gene x environment interaction. We explored the metabolomic antecedents of hypertension in a sample of African Americans (AAs) in the ARIC study. Methods: We examined 896 (565 females, aged 45-64 years) baseline normotensives, whose serum metabolome was measured by gas chromatography-mass spectrometry/ liquid chromatography-mass spectrometry. The analyses presented here focus on 204 metabolites having high 4-6 week intra-individual repeatability (reliability coefficients ≥ 0.60). We used principal-components analyses (PCA) to identify patterns in these metabolomic data. Weibull parametric models considering interval censored data were used to assess the hazard ratio of developing hypertension. The analyses adjusted for age, gender, leisure-time physical activity, smoking status, alcohol intake, diabetes status, BMI, and estimated glomerular filtration rate in the full model. An additional model adjusted for the previous variables plus baseline systolic and diastolic BP. We used a modified Bonferroni correction accounting for the correlations among metabolites to determine statistical significance (p &lt;3.9×10-4) in the analysis of association between an individual metabolite and hypertension. Results: During 10-years of follow-up, 38% of baseline normotensives developed hypertension (N=344; incidence rate: 63.94 per 1000 person-years). Each SD of baseline 4-hydroxyhippurate, a product of gut microbial fermentation, was associated with 17% higher risk of hypertension (p=2.5×10-4), which remained significant after adjusting for baseline BP (p=3.8×10-4). PCA showed three interpretable metabolomic patterns: sex steroids, alpha amino acids and branched-chain amino acids. The sex steroids pattern mainly consisted of androstenediol and pregnendiol disulfate, and it was significantly associated with risk of incident hypertension independent of all factors in the full model (highest versus lowest quintile HR, 1.72; 95% CI, 1.05 to 2.82; p for trend=0.03). Stratified analyses suggested this association was consistent in both genders. Conclusions: In our study of ARIC AAs with 204 reliable metabolites, one metabolite (4-hydroxyhippurate) and one pattern of sex steroids were identified as biomarkers of incident hypertension independent of measured traditional risk factors. Metabolomic analyses such as these may identify novel biomarkers or pathways in the etiology of hypertension and point to new prevention strategies.
Nosocomial Pneumonia Elicits an Endothelial Proteinopathy: Evidence for a Source of Neurotoxic Amyloids in Critically Ill Patients
Authors: Mike T. Lin, Ron Balczon, Jean-Francois Pittet, Brant M. Wagener, Stephen A. Moser, K. Adam Morrow, Sarah Voth, C. Michael Francis, Silas Leavesley, Jessica Bell, Diego F. Alvarez, Troy Stevens
Journal: American Journal of Respiratory and Critical Care Medicine (2018)
AB0976 Efficacy of intra-articular injection of prp- drived growth factor (PRP WITHOUT PLATELET AND WBC) versus hyaluronic acid on pain and function of patients with knee osteoarthritis: a single-blinded randomised clinical trial
Authors: S.A. Raeissadat, A. gharooee ahangar, S.M. Rayegani
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Knee osteoarthritis is the most common joint disease. <h3>Objectives</h3> We aimed to compare the efficacy and safety of intra-articular injection of PRP-drived growth factor versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis. <h3>Methods</h3> In this single-blinded randomised clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of PRP-drived growth factor in 3 weeks or 3 weekly injections of HA. Our primary outcome was the mean change from baseline until 2 and 6 months post intervention in scores of visual analogue scale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lequesne index. <h3>Results</h3> A total of 69 patients entered final analysis. The mean age of patients was 58.2 ± 7.41 years and 81.2% were women. Total WOMAC index decreased from 42.9 ± 13.51 to 26.8 ± 13.45 and 24.4 ± 16.54 at 2 and 6 months in the PRGF group (within subjects p = 0.001), and from 38.8 ± 12.62 to 27.8 ± 11.01 and 27.4 ± 11.38 at 2 and 6 months in the HA group (within subjects p = 0.001), respectively (between subjects p = 0.631). There was no significant difference between PRP-drived growth factor and HA groups in patients' satisfaction and minor complications of injection, whereas patients in HA group reported significantly lower injection-induced pain. 7.4±1.48 At 2 month 5.9±2.65 20.6±8.04 1.2±1.39 27.8±11.01 4.8±1.80 At 6 month 5.9±2.79 20.1±7.77 1.3±1.48 27.4±11.38 4.8±2.39 P value within groups 0.0001 0.0001 0.0001 0.0001 0.0001 P value Between Groups 0.847 0.894 0.189 0.985 0.648 <h3>Conclusions</h3> In 6 months follow up, PRP-drived growth factor and HA, both are effective options to decrease pain and improvement of function in patients with mild to moderate knee osteoarthritis. <h3>References</h3> [1] Raeissadat, SA, Babaee, M, Rayegani, SM. An overview of platelet products (PRP, PRGF, PRF, etc.) in the Iranian studies [published onlineahead of print July 28, 2017]. Futur Sci OA. doi:10.4155/fsoa-2017-0045. [2] Raeissadat, SA, Rayegani, SM, Babaee, M, Ghorbani, E. The effect of platelet-rich plasma on pain, function, and quality of life of patients with knee osteoarthritis. Pain Res Treat. 2013;2013:165967. Google Scholar [3] Raeissadat, SA, Rayegani, SM, Hassanabadi, H. Knee osteoarthritis injection choices: platelet-rich plasma (PRP) versus hyaluronic acid (a one-year randomized clinical trial). Clin Med Insights Arthritis Musculoskelet Disord. 2015;8:1–8. [4] Raeissadat SA, Rayegani SM, Moridnia M, Dehgolan SR. Intra articular ozone or hyaluronic acid injection: which one is superior in patients with knee osteoarthritis? a 6-month randomized clinical trial.Annals of the Rheumatic Diseases2017;76(Suppl 2):1547–1548. <h3>Disclosure of Interest</h3> None declared
Need for Automated Interactive Genomic Interpretation and Ongoing Reanalysis
Authors: Mahdi Sarmady, Ahmad Abou Tayoun
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Abstract 12536: Changes In Pulsed Tissue Doppler Parameters Following Anthracycline-based Chemotherapy
Authors: José M Serrano, Carmen Cristobal, Alejandro Curcio, Pedro Talavera, MarÍa Luaces, Rosa M Jiménez, Catherine Graupner, Luis J Morales, Iria González, Juan A Guerra, Joaquin J Alonso
Journal: Circulation (2012)

Background: Pulsed Tissue Doppler Imaging (TDI) is a validated tool for the assessment of systolic and diastolic function. Data about changes in pulsed-TDI parameters in patients (Pts) following An...
Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer
Authors: Amilcar Flores-Morales, Tobias B. Bergmann, Charlotte Lavallee, Tanveer S. Batth, Dong Lin, Mads Lerdrup, Stine Friis, Anette Bartels, Gitte Kristensen, Agnieszka Krzyzanowska, Hui Xue, Ladan Fazli, Klaus H. Hansen, Martin A. Røder, Klaus Brasso, José M. Moreira, Anders Bjartell, Yuzhuo Wang, Jesper V. Olsen, Colin C. Collins, Diego Iglesias-Gato
Journal: Clinical Cancer Research (2018)

An increasing number of castration-resistant prostate cancer (CRPC) tumors exhibit neuroendocrine (NE) features. NE prostate cancer (NEPC) has poor prognosis, and its development is poorly understood.Experimental Design: We applied mass spectrometry-based proteomics to a unique set of 17 prostate cancer patient-derived xenografts (PDX) to characterize the effects of castration in vivo, and the proteome differences between NEPC and prostate adenocarcinomas. Genome-wide profiling of REST-occupied regions in prostate cancer cells was correlated to the expression changes in vivo to investigate the role of the transcriptional repressor REST in castration-induced NEPC differentiation.An average of 4,881 proteins were identified and quantified from each PDX. Proteins related to neurogenesis, cell-cycle regulation, and DNA repair were found upregulated and elevated in NEPC, while the reduced levels of proteins involved in mitochondrial functions suggested a prevalent glycolytic metabolism of NEPC tumors. Integration of the REST chromatin bound regions with expression changes indicated a direct role of REST in regulating neuronal gene expression in prostate cancer cells. Mechanistically, depletion of REST led to cell-cycle arrest in G1, which could be rescued by p53 knockdown. Finally, the expression of the REST-regulated gene secretagogin (SCGN) correlated with an increased risk of suffering disease relapse after radical prostatectomy.This study presents the first deep characterization of the proteome of NEPC and suggests that concomitant inhibition of REST and the p53 pathway would promote NEPC. We also identify SCGN as a novel prognostic marker in prostate cancer.
Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients
Authors: Kore Schlottau, Leonie Forth, Klemens Angstwurm, Dirk Höper, Daniel Zecher, Friederike Liesche, Bernd Hoffmann, Victoria Kegel, Daniel Seehofer, Sabine Platen, Bernd Salzberger, Uwe G Liebert, Hans-Helmut Niller, Barbara Schmidt, Kaspar Matiasek, Markus J Riemenschneider, Christoph Brochhausen, Bernhard Banas, Lutz Renders, Philipp Moog, Silke Wunderlich, Christian L Seifert, Ana Barreiros, Axel Rahmel, Jutta Weiss, Dennis Tappe, Christiane Herden, Jonas Schmidt-Chanasit, Martin Schwemmle, Dennis Rubbenstroth, Jürgen Schlegel, Corinna Pietsch, Donata Hoffmann, Jonathan Jantsch, Martin Beer
Journal: New England Journal of Medicine (2018)

Fatal Zoonotic Viral Infection after Transplantation Evidence of Borna disease virus 1 infection in humans is limited; in this report, donor-derived Borna virus encephalitis is shown to occur in three solid-organ transplant recipients.
Abstract IA24: Are tumors predictable? Inherited immune variation constrains tumor evolution
Authors: Rachel Marty, Saghar Kaabinejadian, David Rossel, Michael J. Slifker, Joris Van de Haar, Hattice Billur Engin, Nicola de Prisco, Trey Ideker, William H. Hildebrand, Joan Font-Burgada, Hannah Carter
Journal: Clinical Cancer Research (2018)

Abstract Recent studies have characterized the extensive somatic alterations that arise during cancer, and various studies have probed rare inherited mutations that lead to early-onset cancer syndromes. However, little is understood about the role of genetic background in “sporadic” adulthood cancers. The somatic evolution of a tumor may be significantly affected by inherited polymorphisms carried in the germline. The region encoding the Major Histocompatibility Complex Class I (MHC-I) is one of the most variable regions in the human population. MHC-I is a molecule that exposes the intracellular protein content of a cell on the cell surface, allowing T cells to detect mutated or foreign peptides. Each individual carries six MHC-I alleles that define the set of peptides that can be effectively presented for immune surveillance. We hypothesized that individual variation in MHC-I could create personal gaps in immune surveillance, generating individual-specific susceptibility for cells to acquire specific oncogenic mutations. We tested this hypothesis through the development and application of a residue-centric patient presentation score to 1,018 recurrent oncogenic mutations in 9,176 cancer patients. This analysis found that cancer-causing mutations were more likely to be observed when a patient’s genotype-based scores suggested poor MHC-I based presentation of those mutations. Mutations that were poorly presented by most patients were also more likely to reach high frequency among tumors. Thus the landscape of oncogenic mutations observed in clinically diagnosed tumors is shaped by MHC-I genotype-restricted immunoediting during tumor formation, and individual MHC-I genotype provides information about the mutations likely to emerge in tumors that develop later in life. Citation Format: Rachel Marty, Saghar Kaabinejadian, David Rossel, Michael J. Slifker, Joris Van de Haar, Hattice Billur Engin, Nicola de Prisco, Trey Ideker, William H. Hildebrand, Joan Font-Burgada, Hannah Carter. Are tumors predictable? Inherited immune variation constrains tumor evolution [abstract]. In: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; Jan 8-11, 2018; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(17_Suppl):Abstract nr IA24.
Abstract 21281: Cardiosphere-Derived Cell and Mesenchymal Stem Cell Extracellular Vesicles Contain Distinct RNA Cargo
Authors: Ann-Sophie Walravens, Lauren Kelly, Kiel Peck, Linda Marbán, Geoffrey de Couto, Luis R.-Borlado
Journal: Circulation (2017)

Introduction: Cardiosphere-derived cells (CDCs) possess regenerative, immunomodulatory and cardioprotective characteristics when delivered to the heart post-myocardial infarction (MI). CDCs derived from different donors possess variable regenerative potency in a MI model. We previously demonstrated that human CDC-derived extracellular vesicles (CDC-EVs) recapitulate the effects of CDCs in acute and chronic in vivo MI models. We are testing the hypothesis that a distinct cargo profile defines the functional efficacy between CDC-EVs and mesenchymal stem cell-derived EVs (MSC-EVs). Also, we assessed the immunomodulatory role of CDC-EVs derived from potent and non-potent CDCs in comparison with MSC-EVs. Methods: CDCs or MSCs were cultured in serum-free medium for 15 days and the conditioned media was concentrated by ultrafiltration to isolate EVs. The miRNeasy Serum/Plasma kit was used to extract total RNA from EVs followed by small RNA sequencing (NextSeq 500, Illumina) (CDC-EVs, n =12; MSC-EVs, n =4). We performed an in vitro and in vivo macrophage assay to assess the immunomodulatory role of EVs. Results: RNA sequencing analysis of CDC-EVs and MSC-EVs revealed a greater overall abundance of Y-RNA fragments and miRNA in CDC-EVs. Examining the specific Y-RNA classes, we found that MSC-EVs contained an expression profile with lower Y4 (p&lt;0.05) but higher Y5 (p&lt;0.05) Y-RNA fragments. Four miRNAs (miR-146a, miR-151, miR-409, miR-423) were highly enriched in CDC-EVs while miR-10a and miR-4792 were more abundant in MSC-EVs. EVs from potent CDCs showed a stronger upregulation of anti-inflammatory genes in activated macrophages ( in vitro ) and prevented accumulation of macrophages ( in vivo ) when compared with EVs obtained from non-potent CDCs or MSCs. Conclusions: We demonstrated that CDC-EVs contain a unique RNA cargo set that can differentiate CDC-EVs from MSC-EVs. The higher presence of Y-RNA in CDC-EVs as compared to MSC-EVs could be responsible for the ability of CDCs to regulate stem cell activation and tissue regeneration. The highly enriched panel of miRNAs observed in CDC-EVs and the ability to reduce the inflammatory reaction by macrophages, in contrast to MSC-EVs, suggest that they may support some of the functional benefits observed post-MI.
Can primary tumor markers of cancer-initiating cells predict lymph node positivity in breast cancer patients?
Authors: Anees B. Chagpar, Veronique Neumeister, Donald R. Lannin, David Rimm
Journal: Journal of Clinical Oncology (2012)

1121 Background: Cancer initiating cells, characterized by ALDH1 positivity and/or colocalization of ALDH1 and CD44, have been shown to be associated with poor prognosis in breast cancer patients. The prognostic value of these tumor markers with respect to prediction of lymph node (LN) status remains unclear. Methods: Tissue microarrays from a cohort of 223 breast cancer patients diagnosed between 2003 and 2007 were evaluated using the AQUA method for quantitative immunofluorescence for CD44 and ALDH1. These data, along with other clinicopathologic data, were correlated with LN positivity. Results: The median patient age of the cohort was 56 (range; 26-89), with a median tumor size of 1.5 cm. 72 (32.0%) patients were LN positive. The median number of LNs excised was 3 (range; 1-27). Of the LN positive patients, the median number of positive LNs was 1.5 (range; 1-24). Levels of CD44, ALDH1, and ALDH1 colocalizing with CD44 did not correlate with number of positive LNs (Spearman rho coefficients: -0.042, 0.131, and 0.058, respectively), nor overall LN status. Tumor size and lymphovascular invasion (LVI) were the only factors found to be significantly correlated with LN status. Conclusions: While ALDH1 colocalized with CD44 has been found to be associated with poor prognosis in breast cancer patients, these markers do not predict LN status. Given that the only factors that reliably predict LN status are tumor size and LVI, further work is required to find primary tumor markers that may predict LN status in order to spare patients axillary surgery. [Table: see text]
Abstract 19289: Left Bundle Branch Block in Patients With Acute Myocardial Infarction: Presentation, Treatment and 20-Years Trends in Outcome From the Acute Myocardial Infarction in Switzerland (amis) Plus Registry
Authors: Juan F. Iglesias, Sophie Degrauwe, Franz R Eberli, Hans Rickli, Philip Urban, René Simon, Dragana Radovanovic, Paul Erne
Journal: Circulation (2016)

Introduction: Current guidelines recommend urgent reperfusion therapy, preferably primary percutaneous coronary intervention (pPCI), in patients with ongoing myocardial ischemia and persistent ST-segment elevation (STE) or new or presumed new left bundle branch block (LBBB). Whether new or presumed new LBBB should be managed as a STE-equivalent in contemporary clinical practice remains controversial. Methods: We analyzed data from on a large, nationwide, prospective, multicenter registry of patients admitted with acute myocardial infarction (AMI) in Switzerland (AMIS). Descriptive statistics and multivariate logistic regression were used to compare baseline characteristics, treatment and outcomes between patients with STE and new or presumed new LBBB. Results: From 1997 to June 2016, 29114 patients with AMI (STE, 91.8%; LBBB, 6.2%) were included. Compared to the STE patients, patients with LBBB were older, with higher cardiovascular risk profile, greater burden of pre-existing comorbidities, longer reperf...
Treatment of male pattern alopecia with platelet-rich plasma: A double-blind controlled study with analysis of platelet number and growth factor levels
Authors: Bruno L. Rodrigues, Silmara A.L. Montalvão, Rebeca B.B. Cancela, Francesca A.R. Silva, Aline Urban, Stephany C. Huber, José Luiz R.C. Júnior, José Fábio S.D. Lana, Joyce M. Annichinno-Bizzacchi
Journal: Journal of the American Academy of Dermatology (2018)
Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline
Authors: David J. Feller-Kopman, Chakravarthy B. Reddy, Malcolm M. DeCamp, Rebecca L. Diekemper, Michael K. Gould, Travis Henry, Narayan P. Iyer, Y. C. Gary Lee, Sandra Z. Lewis, Nick A. Maskell, Najib M. Rahman, Daniel H. Sterman, Momen M. Wahidi, Alex A. Balekian
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Section:ChooseTop of pageAbstract <<ContentsSummary of Recommendation...IntroductionMethodsRecommendations for Speci...DiscussionReferencesCITING ARTICLES
Abstract 15944: ALDH1A3 Regulates Chromatin Remodeling and Smooth Muscle Proliferative Genes in PAH
Authors: Dan Li, Zhixin Zhao, Ningyi Shao, Jan Hennigs, Kazuya Miyagawa, Marlene Rabinovitch
Journal: Circulation (2017)

Pulmonary arterial hypertension (PAH) is a life-threatening disease that is not effectively cured by current therapies. It is characterized by progressive occlusion of the vascular lumen owing to t...
Abstract 20449: Differential Effects of Hookah and Cigarette Smoking on Endothelial Function: Role of Charcoal Combustion
Authors: Mary Rezk-Hanna, O’Neil Mason, Ryan Rosenberry, Donald Tashkin, Neal L Benowitz, Lynn V Doering, Wendie Robbins, Linda Sarna, Robert Elashoff, Ronald Victor
Journal: Circulation (2016)

Introduction: Hookah (water pipe) smoking is a new global epidemic of tobacco abuse affecting youth. While hookah smokers endorse social media claims that hookah is healthier than cigarettes, there...
Abstract 20631: Mechanistic Validation of the 2016 American Society of Echocardiography Guidelines for Assessment of Diastolic Dysfunction
Authors: Ythan H Goldberg, David Megyessi, Mischa Flam, Daniel M Spevack, Martin Sundqvist, Martin Ugander
Journal: Circulation (2016)

Introduction: The American Society for Echocardiography 2016 guidelines for assessment of diastolic dysfunction (DD) are based on a phenomenological rather than direct mechanistic assessment. The P...
Abstract P219: Plasma Uric Acid and Risk of Type 2 Diabetes: The Influence of a Uric Acid Related Dietary Pattern and Metabolic Risk Factors
Authors: Ivonne Sluijs, Joline W Beulens, Daphne L van der A, Annemieke M Spijkerman, Matthias B Schulze, Yvonne T van der Schouw
Journal: Circulation (2012)

Background: Current evidence suggests a positive relation of uric acid with diabetes risk, but it is still unclear whether this association is independent of other risk factors such as obesity and diet. Objective: To investigate whether plasma uric acid concentrations are independently associated with incident type 2 diabetes, and to investigate the role of a uric acid related dietary pattern in this association. Methods: We used a case-cohort study, nested in the European Prospective Investigation into Cancer and Nutrition - Netherlands (EPIC-NL) study. The study included 2318 subcohort members and 845 incident diabetes cases, with a mean follow-up of 10 years. At baseline, blood samples were taken and diet was assessed using a validated food frequency questionnaire. A dietary pattern was obtained with reduced rank regression. Diabetes was mainly self-reported, and verified against general practitioner records. Results: Mean plasma uric acid concentrations were 275 and 217 µmol/L for males and females respectively. After adjustment for age, sex, measures of adiposity, hypertension, biochemical markers and other confounders, uric acid related to a statistically significant higher risk of diabetes (HR 1.59 [95%CI: 1.06, 2.40]). A uric acid related dietary pattern (high: alcohol, meat , French fries, sugared soft drinks, snacks, low-fibre bread, low: soy products, tea) did not influence the relation. Conclusions: This study supports that high uric acid concentrations increase risk of diabetes, independent of risk factors such as obesity and diet.