tbuckley/cabot-search huggingface dataset:
Importance of Sex-Specific Regression Models to Estimate Synthetic Hematocrit and Extracellular Volume Fraction
Authors: Eng-How Lim, Thu-Thao Le, Jennifer Bryant, Yiu-Cho Chung, Boyang Su, Julian Gan, Derek J. Hausenloy, Stuart A. Cook, Calvin W.L. Chin
Journal: JACC. Cardiovascular imaging (2018)
ANASTOMOSIS OF THE LEFT VENTRICULAR ASSIST DEVICE OUTFLOW GRAFT TO THE AXILLARY ARTERY IN A PATIENT WITH A HOSTILE CHEST
Authors: Abdallah Sanaani, Srikanth Yandrapalli, Wilbert Aronow, Mohammad Karim, David Spielvogel, Masashi Kai, Julio Panza, Gregg Lanier
Journal: Journal of the American College of Cardiology (2018)
Microarray to reveal LncRNA profile and the role of lncCUEDC1 in BCSCs.
Authors: Fengchun Zhang, Ying chun Xu, Ning Yan
Journal: Journal of Clinical Oncology (2018)

3 Background: Recently, a growing amount of reports have shown that long non-coding RNAs (lncRNAs) are involved in breast cancer development, progression and metastasis. However, the correlation between lncRNAs and breast cancer stem cells (BCSCs) has been poorly explored. Methods: We initially isolated BCSCs from mammosphere-cultured cells; then, microarray analyses were carried out to detect the lncRNA signature in BCSCs. In addition, bioinformatics analyses, including Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG), were consulted to explore the functional roles of lncRNAs on BCSCs. Results: A total of 142 aberrantly expressed lncRNAs in BCSCs were identified, and of those lncRNAs, 25 were downregulated and 117 were upregulated compared to non-BCSCs. In addition, some of these lncRNAs were randomly selected and verified by RT-PCR and sanger sequencing. Notably, bioinformatics data showed that the lncRNAs that were detected were largely associated with stemness-related signalling pathways. Additionally, an interacting network between lncRNAs and its mRNAs was constructed to further depict the lncRNA functional activities. Furthermore, we found that lncCUEDC1 negatively regulated phenotype and biological functions of BCSCs in vitro. Conclusions: Our work establishes the lncRNAs signature in BCSCs for the first time. These findings provide us with evidence to explore the functionalities of lncRNAs in BCSCs and indicate that lncCUED1 is a prospective target for BCSCs.
ACUTE AND SHORT-TERM RESULTS OF TRANSCATHETER TREATMENT OF SEVERE TRICUSPID REGURGITATION USING THE EDGE-TO-EDGE REPAIR SYSTEM
Authors: Daniel Braun, Mathias Orban, Michael Nabauer, Andrea Englmaier, Thomas Stocker, Christian Hagl, Steffen Massberg, Joerg Hausleiter
Journal: Journal of the American College of Cardiology (2018)
Detection of Antibodies in Serum and Lymphocytes of Patients with Hemorraghic Fever with Renal Syndrome
Authors: Ekaterina E. Garanina, Egor V. Okhezin, Ekaterina V. Martynova, Venera G. Shakirova, Albert Rizvanov, Svetlana Khaiboullina
Journal: Blood (2017)
New Tobacco Products With Fewer Advertising Restrictions and Consequences for the Current Generation of Youths
Authors: Adam M. Leventhal, Jessica L. Barrington-Trimis
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials
Authors: Karen A. Hicks, Kenneth W. Mahaffey, Roxana Mehran, Steven E. Nissen, Stephen D. Wiviott, Billy Dunn, Scott D. Solomon, John R. Marler, John R. Teerlink, Andrew Farb, David A. Morrow, Shari L. Targum, Cathy A. Sila, Mary T. Thanh Hai, Michael R. Jaff, Hylton V. Joffe, Donald E. Cutlip, Akshay S. Desai, Eldrin F. Lewis, C. Michael Gibson, Martin J. Landray, A. Michael Lincoff, Christopher J. White, Steven S. Brooks, Kenneth Rosenfield, Michael J. Domanski, Alexandra J. Lansky, John J.V. McMurray, James E. Tcheng, Steven R. Steinhubl, Paul Burton, Laura Mauri, Christopher M. O’Connor, Marc A. Pfeffer, H.M. James Hung, Norman L. Stockbridge, Bernard R. Chaitman, Robert J. Temple
Journal: Circulation (2018)

This publication describes uniform definitions for cardiovascular and stroke outcomes developed by the Standardized Data Collection for Cardiovascular Trials Initiative and the US Food and Drug Administration (FDA). The FDA established the Standardized Data Collection for Cardiovascular Trials Initiative in 2009 to simplify the design and conduct of clinical trials intended to support marketing applications. The writing committee recognizes that these definitions may be used in other types of clinical trials and clinical care processes where appropriate. Use of these definitions at the FDA has enhanced the ability to aggregate data within and across medical product development programs, conduct meta-analyses to evaluate cardiovascular safety, integrate data from multiple trials, and compare effectiveness of drugs and devices. Further study is needed to determine whether prospective data collection using these common definitions improves the design, conduct, and interpretability of the results of clinical trials.
Abstract MP57: Unfavorable Perceived Neighborhood Environment Associates With Lower Levels of Routine Healthcare Utilization: Data From the Dallas Heart Study, 2007-2009
Authors: Joniqua Ceasar, Colby Ayers, Marcus Andrews, Sophie Claudel, Kosuke Tamura, Sandeep Das, Ian Neeland, Tiffany M Powell-Wiley
Journal: Circulation (2018)

Background: It is well documented that perceived neighborhood environment is associated with cardiovascular (CV) health factors but little is known about how neighborhood environment perception (NEP) relates to routine healthcare utilization, a likely determinant of CV health outcomes. Methods: Using cross-sectional Dallas Heart Study data, we examined the relationship between NEP and routine healthcare utilization. NEP was defined via total score and sub-scores using factor analysis [perceived neighborhood violence, physical environment (i.e. aesthetics), and social cohesion; higher score=more unfavorable perception]. Routine healthcare utilization was based on self-reported time since last visit to a healthcare provider for routine checkup. We used linear regression to determine the relationship between NEP scores and routine healthcare visits, adjusting for age, sex, race/ethnicity, income, education, health insurance status, CV disease burden, and neighborhood deprivation index (NDI). Results: Within the study population (N=1756; 58% black, 27% white and 15% Hispanic), those who reported more recent routine visits were found to be older, more educated and have higher income. When adjusting for confounders (Table), more unfavorable NEP was associated with less frequent routine healthcare visits. Specifically, individuals who perceived a more unfavorable neighborhood physical environment or greater violence level reported greater time since last routine visit. There was no relationship between perceived social cohesion and healthcare usage. Conclusions: Unfavorable NEP was found to significantly relate to decreased routine healthcare utilization even when accounting for health insurance, CV disease and NDI. Furthermore, unfavorable perceived neighborhood violence and physical environment are associated with less routine healthcare utilization. Our findings suggest that NEP may act as a barrier to routine preventive healthcare and ideal CV health outcomes in at-risk communities.
Turning frustration into action
Authors: Tom Moberly
Journal: BMJ (2014)

Rising workload pressure, attacks on pay and pensions, and the denigration of the medical profession by politicians and the media are leaving many doctors exasperated. Many in the profession believe that these three forces are undermining morale and may be generating huge workforce problems for the next generation. Doctors’ anger over these issues was clear at last month’s annual representative meeting of the BMA (http://careers.bmj.com/careers/advice/view-article.html?id=20018302 …
Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients With Crohn’s Disease
Authors: Nan Lan, Luca Stocchi, Jean H. Ashburn, Tracy L. Hull, Scott R. Steele, Conor P. Delaney, Bo Shen
Journal: Clinical Gastroenterology and Hepatology (2018)
Ultrasound Molecular Imaging of Atherosclerosis for Early Diagnosis and Therapeutic Evaluation through Leucocyte-like Multiple Targeted Microbubbles
Authors: Fei Yan, Yu Sun, Yang Mao, Meiying Wu, Zhiting Deng, Shuai Li, Xin Liu, Li Xue, Hairong Zheng
Journal: Theranostics (2018)

Cardiovascular diseases resulting from atherosclerosis have become a serious threat to human health. It is well-known that an ongoing inflammatory response is involved during atherosclerosis progression that ultimately results in the accumulation of lipids and formation of plaques. Monitoring the pathological changes during the inflammatory response will be of great significance for early diagnosis and therapeutic evaluation of atherosclerosis. Targeted contrast-enhanced ultrasonography has been shown to be a promising noninvasive imaging technique for evaluating the degree of atherosclerosis and may potentially be translated to clinical imaging in the future. However, inadequate cell adhesion of targeted microbubbles (MBs) in large arterial vessels still remains a great challenge. Methods: By mimicking the leucocytes that are recruited to the vessel wall during the initiation of atherosclerosis through selectin-dependent arrest and cell adhesion molecule-mediated firm cell adhesion, we developed VCAM-1/ICAM-1/P-selectin-targeted MBVIS by integrating VCAM-1 and ICAM-1 antibodies and synthetic polymeric sialyl Lewis X (sLex) onto the MB surface. Results: The resulting MBVIS had a high affinity to inflammatory bEnd.3 cells in both static and dynamic flow conditions. Significantly enhanced ultrasound imaging signals were achieved by MBVIS in detecting the atherosclerosis progress when compared with the single- or dual-targeted MBs. Taking advantage of the artificial MBVIS, less ultrasound imaging signals were found in the atorvastatin-treated, but not placebo-treated, ApoE-deficient mice with atherosclerosis, revealing a potential therapeutic efficacy of atorvastatin for early stage atherosclerosis. This was further confirmed by histologic staining examination. Conclusions: Our study provides a promising ultrasound molecular imaging probe for early-stage diagnosis and therapeutic evaluation of atherosclerosis.
David Oliver: Do bed and chair sensors really stop falls in hospital?
Authors: David Oliver
Journal: BMJ (2018)

In December a coroner’s narrative verdict was widely covered in the media. “Frail hospital patients put at risk for want of basic equipment costing less than £100, coroner warns,” reported the Telegraph .1 The verdict concerned Ken Swift, 80, a retired nurse who had been admitted to York Hospital with pneumonia. He fell from his hospital bed and sustained a hip fracture, which the coroner said was likely to have contributed to his death.

Bed and chair sensors had been recommended as part of Swift’s care plan. These devices trigger an alarm or warning light if patients leave their bed or chair for a few seconds. Staff can then, in theory, respond quickly and intervene to prevent a fall or assist the …
Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma
Authors: Ayano Kabashima, Petra Hirsova, Steven F. Bronk, Matthew C. Hernandez, Mark J. Truty, Sumera I. Ilyas, Scott H. Kaufmann, Gregory J. Gores
Journal: Journal of Hepatology (2018)
Flu vaccination: an opt-out system for healthcare workers
Authors: Noah C V Blackmore
Journal: BMJ (2018)

McCartney makes a valid point about the questionable effectiveness of the flu vaccine, but she provides little substantive evidence of the negative effects of vaccination.1 She quotes the 2016-17 effectiveness of 41% in adults under 65, which would have been sufficient to provide herd immunity in many recent influenza outbreaks …
LOW LEVEL LASER PHOTOBIOMODULATION STABILIZES AORTIC SMOOTH MUSCLE CELL MITOCHONDRIAL MEMBRANE POTENTIAL: RELEVANCE TO THE PREVENTION OF PROGRESSION OF ABDOMINAL AORTIC ANEURYSM
Authors: Lilach Gavish, Ronen Beeri, Dan Gilon, Chen Rubinstein, S. David Gertz
Journal: Journal of the American College of Cardiology (2018)
Abstract 12072: Damage to Coating Polymer Can Cause Serious Complications After Drug-Eluting Stent Implantation: A Pathological Study in Human Coronary Arteries
Authors: Katsumi Inoue, Masao Imai, Takeshi Kimura
Journal: Circulation (2016)

Introduction: Polymer coating is indispensable to optimize controlled drug release kinetics following drug-eluting stent (DES) implantation. However, how it can be damaged during the stenting procedure and the subsequent clinico-pathological events are not well studied. Hypothesis: We histopathologically assessed the hypothesis that damage to polymer coating can hinder DES efficacy. Methods: The study sample comprised 32 DES-implanted lesions obtained by autopsy from 2.5 to 49 months after stenting: 27 with durable polymers (Cypher, 12; Taxus, 6; Endeavor, 4; and Xience, 5) and 5 with biodegradable polymers coated only on the abluminal surface (Nobori, 3 and Ultimaster, 2). Tortuous lesions accounted for 60% and calcified lesions for 88%. We examined microscopically at least six slices from each lesion. Results: Polymer cracking or delamination was observed in about 6% of Cypher struts and 4% of Taxus struts. In two Cypher-implanted lesions with stent thrombosis occurring beyond one year after stent implantation, significant detachment of polymer fragments phagocytosed by giant cells was observed, and their arterial walls were aneurysmally dilated with extensive inflammatory infiltration of the intima, media, and adventitia, predominantly consisting of T cells, eosinophils, and considerable giant cells. In Xience-implanted lesions, polymer damage was little. In contrast, in most Endeavor-implanted lesions, large spallings of the polymer were found, and numerous phagocytosed polymer remnants scattered in the thickened neointima. In Nobori- or Ultimaster-implanted calcified lesions within 4 months after the procedure, remarkable detachment of polymer coating resulted in severe inflammatory reaction consisting of macrophages and lymphocytes. Conclusions: Polymer disruption may result in nonuniform drug distribution that may allow neointimal hyperplasia in the DES-implanted lesions. Moreover, polymer cracking may induce adverse and interrelated effects such as local inflammation and amplified cellular response, followed by very late stent thrombosis. Compared with polymer around the stent struts, delamination of abluminal polymer might occurr more easily when it is delivered through a calcified coronary artery.
Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway
Authors: Ema Yoshioka, Vipin Shankar Chelakkot, Maria Licursi, Suzette G Rutihinda, Jayoti Som, Leena Derwish, Justin J King, Theerawat Pongnopparat, Karen Mearow, Mani Larijani, Ann M Dorward, Kensuke Hirasawa
Journal: Theranostics (2018)

Protoporphyrin IX (PpIX) is an endogenous fluorescent molecule that selectively accumulates in cancer cells treated with the heme precursor 5-aminolevulinic acid (5-ALA).This cancer-specific accumulation of PpIX is used to distinguish tumor from normal tissues in fluorescence-guided surgery (FGS) and to destroy cancer cells by photodynamic therapy (PDT).In this study, we demonstrate that oncogenic Ras/mitogen-activated protein kinase kinase (MEK) pathway can modulate PpIX accumulation in cancer cells.Methods: To identify Ras downstream elements involved in PpIX accumulation, chemical inhibitors were used.To demonstrate the increase of PpIX accumulation by MEK inhibition, different human normal and cancer cell lines, BALB/c mice bearing mammary 4T1 tumors and athymic nude mice bearing human tumors were used.To identify the mechanisms of PpIX regulation by MEK, biochemical and molecular biological experiments were conducted.Results: Inhibition of one of the Ras downstream elements, MEK, promoted PpIX accumulation in cancer cells treated with 5-ALA, while inhibitors against other Ras downstream elements did not.Increased PpIX accumulation with MEK inhibition was observed in different types of human cancer cell lines, but not in normal cell lines.We identified two independent cellular mechanisms that underlie this effect in cancer cells.MEK inhibition reduced PpIX efflux from cancer cells by decreasing the expression level of ATP binding cassette subfamily B member 1 (ABCB1) transporter.In addition, the activity of ferrochelatase (FECH), the enzyme responsible for converting PpIX to heme, was reduced by MEK inhibition.Finally, we found that in vivo treatment with MEK inhibitors increased PpIX accumulation (2.2to 2.4-fold) within mammary 4T1 tumors in BALB/c mice injected with 5-ALA without any change in normal organs.Similar results were also observed in a human tumor xenograft model. Conclusion:Our study demonstrates that inhibition of oncogenic Ras/MEK significantly enhances PpIX accumulation in vitro and in vivo in a cancer-specific manner.Thus, suppressing the Ras/MEK pathway may be a viable strategy to selectively intensify PpIX fluorescence in cancer cells and improve its clinical applications in FGS.
Accuracy of Dermoscopic Criteria for the Diagnosis of Melanoma In Situ
Authors: Aimilios Lallas, Caterina Longo, Marco Manfredini, Elisa Benati, Graziella Babino, Chiara Chinazzo, Zoe Apalla, Chryssoula Papageorgiou, Elvira Moscarella, Athanassios Kyrgidis, Giuseppe Argenziano
Journal: JAMA Dermatology (2018)

The accuracy of melanoma-specific dermoscopic criteria has been tested mainly in studies including invasive tumors. Scarce evidence exists on the usefulness of these criteria for the diagnosis of melanoma in situ (MIS).To investigate the diagnostic accuracy of dermoscopic criteria for the diagnosis of MIS.A diagnostic accuracy study with retrospective patient enrollment was conducted in 3 centers specializing in skin cancer diagnosis and management. A total of 1285 individuals with histopathologically diagnosed MIS or other flat, pigmented skin tumors that were histopathologically diagnosed or monitored for at least 1 year were included. Dermoscopic images of MIS and other flat, pigmented skin tumors were evaluated by 3 independent investigators for the presence of predefined criteria. Evaluators were blinded to the clinic dermoscopic and histopathologic diagnosis.Frequencies of dermoscopic criteria per diagnosis were calculated. Crude odds ratios, adjusted odds ratios, and corresponding 95% CIs were calculated by univariate and multivariate logistic regression, respectively.A total of 1285 patients were included in the study (642 [50%] male); mean age was 45.9 years (range, 9-91 years). Of a total of 1285 lesions obtained from these patients, 325 (25.3%) were MIS; 574 (44.7%) were nevi (312 [24.3%] excised and 262 [20.4%] not excised); 67 (5.2%) were seborrheic keratoses, solar lentigines, or lichen planus-like keratoses; 91 (7.1%) were pigmented superficial basal cell carcinomas; 26 (2.0%) were pigmented intraepithelial carcinomas; 100 (7.8%) were Reed nevi; and 102 (7.9%) were invasive melanomas with a Breslow thickness less than 0.75 mm. The most frequent dermoscopic criteria for MIS were regression (302 [92.9%]), atypical network (278 [85.5%]), and irregular dots and/or globules (163 [50.2%]). The multivariate analysis revealed 5 main positive dermoscopic indicators of MIS: atypical network (3.7-fold; 95% CI, 2.5-5.4), regression (4.7-fold; 95% CI, 2.8-8.1), irregular hyperpigmented areas (5.4-fold; 95% CI, 3.7-8.0), prominent skin markings (3.4-fold; 95% CI, 1.9-6.1), and angulated lines (2.2-fold; 95% CI, 1.2-4.1). When compared only with excised nevi, 2 of these criteria remained potent MIS indicators, namely, irregular hyperpigmented areas (4.3-fold; 95% CI, 2.7-6.8) and prominent skin markings (2.7-fold; 95% CI, 1.3-5.7).Clinicians should take into consideration the aforementioned dermoscopic indicators for the diagnosis of MIS.
Biofunctional Mg coating on PEEK for improving bioactivity
Authors: Xiaoming Yu, Muhammad Ibrahim, Zongyuan Liu, Huazhe Yang, Lili Tan, Ke Yang
Journal: Bioactive Materials (2018)

High purity Mg was successfully coated on polyetheretherketone (PEEK) by vapor deposition method in order to improve the bioactivity including antibacterial property of PEEK implant. The morphology and elemental composition of the coating were characterized by scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS), showing that the coating was mainly composed of Mg at deposition temperature of 175 °C, 185 °C, 200 °C and 230 °C. The higher the substrate temperature was, the larger the Mg particle size was. The coating degraded and gradually peeled off from the surface of PEEK after up to 21 days' immersion. It was found that the degradation of Mg coating could strongly kill
Medical record keeping: clarity, accuracy, and timeliness are essential
Authors: Wedad Abdelrahman, Abdelrahman Abdelmageed
Journal: BMJ (2014)

Medical records form a permanent account of the care a patient has received. <b>Wedad Abdelrahman </b>and<b> Abdelrahman Abdelmageed </b>explain why it is important that these records are well maintained
SYSTEMIC ENDOTHELIAL DYSFUNCTION AND INCREASED GDF-15 PLASMA LEVELS INPATIENTS WITH PSEUDOEXFOLIATIVE GLAUCOMA
Authors: Evangelos Oikonomou, Evgenia Bourouki, Alexios Antonopoulos, Gerasimos Siasos, Sotirios Tsalamandris, Marilita Moschos, Nikolaos Gouliopoulos, Theodore Paraskevopoulos, Nikolaos Papageorgiou, Effimia Zacharia, Konstantinos Mpatzias, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2018)
The use of gold nanorods as a new vaccine platform against schistosomiasis
Authors: Natan R.G. Assis, Anderson J. Caires, Bárbara C. Figueiredo, Suellen B. Morais, Fábio S. Mambelli, Fábio V. Marinho, Luís O. Ladeira, Sergio C. Oliveira
Journal: Journal of Controlled Release (2018)
Consultant pay proposals could destabilise workforce, warn anaesthetists
Authors: Helen Jaques
Journal: BMJ (2013)

Plans to change consultants’ pay and bonuses could disproportionally affect anaesthetists and destabilise the specialty’s workforce, say the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland.

The two bodies said that “radical” proposals from the Review Body on Doctors’ and Dentists’ Remuneration (DDRB) were unfair in the face of a three year pay freeze and increases in pension contributions. They argued that the proposed changes would be a major disincentive to doctors to engage in the wider NHS at local and national levels.

They suggested that the proposed changes to …