tbuckley/cabot-search huggingface dataset:
Effect of a multifaceted social franchising model on quality and coverage of maternal, newborn, and reproductive health-care services in Uttar Pradesh, India: a quasi-experimental study
Authors: Sarah Tougher, Varun Dutt, Shreya Pereira, Kaveri Haldar, Vasudha Shukla, Kultar Singh, Paresh Kumar, Catherine Goodman, Timothy Powell-Jackson
Journal: The Lancet Global Health (2017)

BackgroundHow to harness the private sector to improve population health in low-income and middle-income countries is heavily debated and one prominent strategy is social franchising. We aimed to evaluate whether the Matrika social franchising model—a multifaceted intervention that established a network of private providers and strengthened the skills of both public and private sector clinicians—could improve the quality and coverage of health services along the continuum of care for maternal, newborn, and reproductive health.MethodsWe did a quasi-experimental study, which combined matching with difference-in-differences methods. We matched 60 intervention clusters (wards or villages) with a social franchisee to 120 comparison clusters in six districts of Uttar Pradesh, India. The intervention was implemented by two not-for-profit organisations from September, 2013, to May, 2016. We did two rounds (January, 2015, and May, 2016) of a household survey for women who had given birth up to 2 years previously. The primary outcome was the proportion of women who gave birth in a health-care facility. An additional 56 prespecified outcomes measured maternal health-care use, content of care, patient experience, and other dimensions of care. We organised conceptually similar outcomes into 14 families to create summary indices. We used multivariate difference-in-differences methods for the analyses and accounted for multiple inference.FindingsThe introduction of Matrika was not significantly associated with the change in facility births (4 percentage points, 95% CI −1 to 9; p=0·100). Effects for any of the other individual outcomes or for any of the 14 summary indices were not significant. Evidence was weak for an increase of 0·13 SD (95% CI 0·00 to 0·27; p=0·053) in recommended delivery care practices.InterpretationThe Matrika social franchise model was not effective in improving the quality and coverage of maternal health services at the population level. Several key reasons identified for the absence of an effect potentially provide generalisable lessons for social franchising programmes elsewhere.FundingMerck Sharp and Dohme Limited.
Targeting BRD4 Disables IL-15 Oncogenic Signaling in Cutaneous T-Cell Lymphoma Via Down Regulation of IL-15 Receptor Complex
Authors: Rebecca Kohnken, Jing Wen, Max Yano, Alex Hartlage, Leah Grinshpun, Michael A. Caligiuri, Pierluigi Porcu, Anjali Mishra
Journal: Blood (2016)
Reframing the Value Proposition of Coronary Artery Bypass Graft Bundles
Authors: Joshua M. Liao, Amol S. Navathe, Danny Chu
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Spiritual Care in Medicine
Authors: Lester Liao
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16233: Detection of Ischemic and Non-ischemic Cardiomyopathy by Gated Single Photon Emission Computed Tomography (SPECT) can be Improved by Novel Application of Phase Analysis Technique
Authors: Pavel Goykhman, Evelina Grayver, Regina Druz
Journal: Circulation (2012)

Background:  Gated SPECT is often abnormal with patchy perfusion pattern in the non-ischemic cardiomyopathy patients. Phase analysis is a novel technique that allows to predict responses to cardiac resynchronization therapy. We investigated if phase analysis differentiates ischemic vs. non-ischemic cardiomyopathy independently of the perfusion.   Methods:  Fifty-eight consecutive patients (2009-2011) with gated SPECT, heart failure and left ventricular ejection fraction (EF) ≤ 35% were age and gender matched into ischemic and non-ischemic cardiomyopathy groups based on coronary angiography and medical records. Gated SPECT studies were processed using Emory Toolbox (Atlanta, GA) with automated derivation of summed stress (SSS), rest (SRS), difference (SDS) scores, perfusion deficit size (PDS), EF, and phase analysis parameters of peak phase, phase standard deviation (SD), histogram bandwidth, skewness, and kurtosis. Sensitivity and specificity for detection of ischemic cardiomyopathy were determined for phase SD ≥ 43 degrees and bandwidth ≥ 135 degrees.   Results:  Mean age was 57.8±9.8 years, 34 men, 24 women. There were more diabetic (20/29 vs. 10/29, p=0.0086) and dyslipidemic (27/29 vs. 14/29, p=0.0002) patients in the ischemic cardiomyopathy group, with insignificantly lower EF: 33.9±9.7 vs. 35.4±7.5. Significant differences between the groups are in the Table. Sensitivity and specificity of detecting ischemic cardiomyopathy independently of perfusion were 79% and 59% for phase SD, and 83% and 66% for histogram bandwidth.   Conclusion:  Non-ischemic cardiomyopathy patients with heart failure were found to have abnormal perfusion pattern on gated SPECT, although with smaller and less severe defects than ischemic cardiomyopathy patients. A novel technique of phase analysis showed good sensitivity and specificity in determining the cause of cardiomyopathy independently of perfusion. The derivation of optimal cut offs is currently in progress.
Adult Stem Cells in Vascular Remodeling
Authors: Dong Wang, LeeAnn K. Li, Tiffany Dai, Aijun Wang, Song Li
Journal: Theranostics (2017)

Understanding the contribution of vascular cells to blood vessel remodeling is critical for the development of new therapeutic approaches to cure cardiovascular diseases (CVDs) and regenerate blood vessels. Recent findings suggest that neointimal formation and atherosclerotic lesions involve not only inflammatory cells, endothelial cells, and smooth muscle cells, but also several types of stem cells or progenitors in arterial walls and the circulation. Some of these stem cells also participate in the remodeling of vascular grafts, microvessel regeneration, and formation of fibrotic tissue around biomaterial implants. Here we review the recent findings on how adult stem cells participate in CVD development and regeneration as well as the current state of clinical trials in the field, which may lead to new approaches for cardiovascular therapies and tissue engineering.
Augmenting the Reduced Intensity Conditioning (RIC) Regimen of Fludarabine (FLU) and Melphalan (MEL) by Addition of Total Marrow and Lymph Node Irradiation (TMLI) Using Helical Tomotherapy in Patients (pts) with Advanced Hematological Malignancies.
Authors: Joseph Rosenthal, Jeffrey Wong, Anthony Stein, Ellen Bolotin, Chatchada Karanes, Leslie Popplwell, Auayporn Nademanee, Firoozeh Sahebi, Margaret O’Donnell, Maria Delioukina, George Somlo, Anna Pawlowska, Debbie Hitt, Marianna Shakhnovits, Stephen Forman
Journal: Blood (2007)
Physical activity for the ageing athlete: the importance of maintaining musculoskeletal health
Authors: Mark E Batt
Journal: British Journal of Sports Medicine (2017)

The term ‘athlete’ has many differing definitions, connotations and stereotypes. For many years, sport and exercise medicine physicians have treated every patient as an athlete to a greater or lesser extent with associated functional, work, sport and social expectations and demands. As we age alongside our patients, we empathise with their changing needs and abilities. People are living longer, but many do so in poor health and with reduced quality of life due to the presence of chronic diseases. Ageing is associated with multi-system decline, including musculoskeletal conditions. In the UK, the greatest cause of pain and disability are musculoskeletal conditions such as osteoarthritis and back pain, and these remain under-recognised as a public health priority.1 The presence of two or more long-term ailments (physical or mental), so called multi-morbidity, is increasingly common in patients from both high-income and low/middle-income economies. Indeed, in the UK, there are 15 million people living with one or more long-term condition accounting for 50% of general practitioner appointments, 70% of hospital bed days and 70% of health and social care …
Expression and activation status of CREB in non-small cell lung cancer
Authors: Hye-Sook Seo, Kounga Cheon, Ignacio I. Wistuba, Ja-Seok Koo
Journal: Cancer Research (2005)

3937  cAMP response element binding protein (CREB) is a transcription factor which is involved in differentiation, cell survival, proliferation and development. To determine the expression level and activation status of CREB in non-small cell lung cancer (NSCLC), we performed immunohistochemical analysis (IHC) using antibodies specific to CREB and phosphorylated CREB at Ser-133 (p-CREB) on tissue specimens (total 85 cases) obtained from various types of lung cancer consisting of adenocarcinoma (40), squamous cell carcinoma (40), and bronchioloalveolar carcinoma (5). We also performed IHC using lung tissue microarray composed of 161 cases of NSCLC. To compare the expression of CREB and p-CREB levels, between normal and tumor samples, immunocytochemistry on normal adjacent lung tissues (18 cases) were performed in parallel. We observed that both CREB and p-CREB were stained significantly greater level in lung tumor than in adjacent normal tissues. We also found that both CREB and p-CREB levels were slightly higher in squamous cell lung carcinoma than in adenocarcinoma. Further Western blot analysis using cell lysates from cultured normal human tracheobronchial epithelial (NHTBE) cells and several NSCLC cell lines showed over-expression of active form of CREB in NSCLC cell lines, in consistent with the immunohistochemical data using NSCLC tissue specimens. Since it has been well documented that many target genes of CREB involved in lung tumorigenesis, these results suggest that over-expression of active CREB play a role in lung cancer development. Hence, the silencing of the expression or inactivation of CREB may hold promise for lung cancer prevention as well as its treatment. Supported by State of Texas Tobacco Settlement Funds.
Rest and return-to-sport recommendations following sport-related concussion (PEDro synthesis)
Authors: Arun Prasad Balasundaram, Anthony G Schneiders, S John Sullivan
Journal: British Journal of Sports Medicine (2017)

McLeod TC, Lewis JH, Whelihan K, Bacon CE. Rest and return to activity after sport-related concussion: a systematic review of the literature. J Athl Train 2017; 52: 262–287.

The international Concussion in Sport group consensus statement advocates rest (physical and cognitive) until the resolution of symptoms following sport-related concussion. It also recommends that athletes follow a graduated stepwise progressive protocol to safely return-to-sport (RTS).1 There is currently insufficient evidence1 for implementation of ‘Rest’ and/or ‘Graduated RTS protocol’ for concussion management, nor precise evidence-informed guidelines in terms of timing, quantity and duration for these interventions.

The aim of the systematic review was to synthesise the literature related to rest and RTS/activity recommendations following sport-related concussion.

The articles were retrieved using the search terms such as brain concussion, mild traumatic brain injury, physical and cognitive rest and return-to-activity. The databases were explored from the time of inception until October 2015, and these included the Cochrane Central Register of Controlled Trials, CINAHL, SPORTDiscus, Educational Resources Information …
Efficacy Against Human Prostate Cancer by Prostate-specific Membrane Antigen-specific, Transforming Growth Factor-β Insensitive Genetically Targeted CD8+ T-cells Derived from Patients with Metastatic Castrate-resistant Disease
Authors: Qiang Zhang, Brian T. Helfand, Benedito A. Carneiro, Weijun Qin, Ximing J. Yang, Chung Lee, Weipeng Zhang, Francis J. Giles, Massimo Cristofanilli, Timothy M. Kuzel
Journal: European Urology (2017)
Plectin controls biliary tree architecture and stability in cholestasis
Authors: Marketa Jirouskova, Katerina Nepomucka, Gizem Oyman-Eyrilmez, Alzbeta Kalendova, Helena Havelkova, Lenka Sarnova, Karel Chalupsky, Bjoern Schuster, Oldrich Benada, Petra Miksatkova, Martin Kuchar, Ondrej Fabian, Radislav Sedlacek, Gerhard Wiche, Martin Gregor
Journal: Journal of Hepatology (2017)
68Ga-PSMA Avid Primary Adenocarcinoma of the Lung With Complementary Low 18F-FDG Uptake
Authors: Mads Ryø Jochumsen, Lars Christian Gormsen, Gitte Lund Nielsen
Journal: Clinical Nuclear Medicine (2017)

Abstract 68 Ga-PSMA PET/CT scan on a 70-year-old man with recently diagnosed prostate cancer revealed a spiculating nodule in the apex of the left lung with intense 68 Ga-PSMA uptake. The nodule had no pathological 18 F-FDG uptake and turned out to be a primary adenocarcinoma of the lung. Cases with complementary pattern of uptake in 18 F-FDG and 68 Ga-PSMA in metastatic clear cell renal carcinoma and in well-differentiated hepatocellular carcinoma have previously been reported; however, this case illustrates that this unusual pattern can also be present in primary lung cancer.
Hyperparathyroidism Caused by Coexisting Parathyroid Hyperplasia and Ectopic Parathyroid Adenomas
Authors: Peng Xie, Jianmin Huang
Journal: Clinical Nuclear Medicine (2017)

Tc sestamibi parathyroid scan was performed in a 35-year-old man with chronic renal failure to evaluate the cause of increased serum parathyroid hormone. Both early and delayed images showed intense activity overlapping the left upper pole of the thyroid, which was proven to be nodular parathyroid hyperplasia after parathyroidectomy. However, the levels of serum parathyroid hormone remained elevated postsurgically. A repeat sestamibi study revealed abnormal activity in the left upper mediastinum, which could also be subtly seen on initial sestamibi study. A retrosternal lesion was resected, which was confirmed as an ectopic parathyroid adenoma by pathological examination.
Negative Capability and the Art of Medicine
Authors: Jack Coulehan
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brote de legionelosis en un municipio
Authors: A M Correia, G Gonçalves, J Reis, J M Cruz, J A Castro e Freitas
Journal: Eurosurveillance (2001)

Once casos de legionelosis, residentes todos en un mismo municipio, fueron ingresados en un hospital regional del norte de Portugal. Las investigaciones preliminares sugerian una relacion con las fiestas anuales celebradas en dicho municipio. No se aislo Legionella pneumophila en ninguna de las fuentes de infeccion sospechosas, pero los resultados de un estudio de casos y controles apuntaron a un aerosol, producido por una fuente decorativa de la plaza mayor durante la noche de un concierto de rock, como probable vehiculo de la infeccion. La prevalencia de tabaquismo fue superior en los casos que en los controles.
The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy
Authors: Jodi A McKenzie, Rina M Mbofung, Shruti Malu, Min Zhang, Emily Ashkin, Seram Devi, Leila Williams, Trang Tieu, Weiyi Peng, Sunila Pradeep, Chunyu Xu, Soraya Zorro Manrique, Chengwen Liu, Lu Huang, Yuan Chen, Marie-Andree Forget, Cara Haymaker, Chantale Bernatchez, Nikunj Satani, Florian Muller, Jason Roszik, Ashish Kalra, Timothy Heffernan, Anil Sood, Jianhua Hu, Rodabe Amaria, R Eric Davis, Patrick Hwu
Journal: JNCI Journal of the National Cancer Institute (2017)

Immunotherapy has increasingly become a staple in cancer treatment. However, substantial limitations in the durability of response highlight the need for more rational therapeutic combinations. The aim of this study is to investigate how to make tumor cells more sensitive to T-cell-based cancer immunotherapy.Two pairs of melanoma patient-derived tumor cell lines and their autologous tumor-infiltrating lymphocytes were utilized in a high-throughput screen of 850 compounds to identify bioactive agents that could be used in combinatorial strategies to improve T-cell-mediated killing of tumor cells. RNAi, overexpression, and gene expression analyses were utilized to identify the mechanism underlying the effect of Topoisomerase I (Top1) inhibitors on T-cell-mediated killing. Using a syngeneic mouse model (n = 5 per group), the antitumor efficacy of the combination of a clinically relevant Top1 inhibitor, liposomal irinotecan (MM-398), with immune checkpoint inhibitors was also assessed. All statistical tests were two-sided.We found that Top1 inhibitors increased the sensitivity of patient-derived melanoma cell lines (n = 7) to T-cell-mediated cytotoxicity (P < .001, Dunnett's test). This enhancement is mediated by TP53INP1, whose overexpression increased the susceptibility of melanoma cell lines to T-cell cytotoxicity (2549 cell line: P = .009, unpaired t test), whereas its knockdown impeded T-cell killing of Top1 inhibitor-treated melanoma cells (2549 cell line: P < .001, unpaired t test). In vivo, greater tumor control was achieved with MM-398 in combination with α-PD-L1 or α-PD1 (P < .001, Tukey's test). Prolonged survival was also observed in tumor-bearing mice treated with MM-398 in combination with α-PD-L1 (P = .002, log-rank test) or α-PD1 (P = .008, log-rank test).We demonstrated that Top1 inhibitors can improve the antitumor efficacy of cancer immunotherapy, thus providing the basis for developing novel strategies using Top1 inhibitors to augment the efficacy of immunotherapy.
Varlitinib to demonstrate anti-tumour efficacy in patient-derived hepatocellular carcinoma xenograft models.
Authors: Chih-Yi Hsieh, Lisa Ooi, Richard Weijie Ong, Bertil Lindmark, Mark McHale, Hung The Huynh
Journal: Journal of Clinical Oncology (2016)

e15598 Background: Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-HER inhibitor that selectively binds to HER1 (IC50 = 7 nM), HER2 (IC50 = 2 nM) and HER4 (IC50 = 4 nM). Hepatocellular carcinoma (HCC) is the most common form of liver cancer and currently sorafenib is the only drug approved for advanced HCC. In the pivotal studies, sorafenib increased the median survival by only three months and there is an urgent need for additional HCC therapies. Several studies have implicated dysregulation of HER signaling in HCC and there is strong scientific rationale for testing of pan-HER therapies in HCC. Methods: We tested the anti-tumour activity of Varlitinib as a single agent in patient-derived HCC xenograft in SCID mice (HCC29-0909A) with co-expression of HER1, HER2 and HER3 recepors. Dosing with Varlitinib commenced when the tumours reached the size of approximately 100-150 mm3. Bi-dimensional measurements are performed twice a week and tumour volumes are calculated based on the following formula: Tumour volume = [(Length) x (Width2) x (p/6)]. Results: Varlitinib treatment potently inhibited tumour growth with complete tumor regression observed at dosing of 100 mg/kg BID. In addition, Varlitinib was well tolerated at all dose levels. Western blot analysis of tumour lysates taken after five days of Varlitinib treatment revealed that phosphorylation of HER1-3, RAS/RAF/MEK/MAPK, p70S6K, S6 ribosomal, 4EBP1, Cdk-2, Cdc-2 and retinoblastoma were strongly inhibited. Furthermore Varlitinib treatment resulted in a significant reduction in survivin and a concomittant increase in Caspase 3 cleavage products. Conclusions: Our data suggest that Varlitinib potently inhibited cancer cell proliferation and induced apoptosis. In the clinical setting Varlitinib has already demonstrated impressive efficacy in breast cancer, gastric cancer, cholangiocarcinoma and colorectal carcinoma with a greatly improved toxicity profile compared to irreversible pan-Her inhibitors such as Neratinib and Dacomitinib. Given the robust and tolerable anti-tumour activity of Varlitinib in PDX models of HCC, ASLAN Pharmaceticals will progress Varlitinib into phase 2 studies in HCC in 2016.
Daily Products Containing Paraben and Triclosan Use and Allergic Diseases In Tokyo, 2016-2017: a Cross-Sectional Study
Authors: Mitsui Motoko, Yamamoto Kiwako, Hirota Ryoji, Muto Go, Nakamura Takeshi, Yuma Fukutomi, Nakamura Hiroyuki, Yukihiro Ohya
Journal: Journal of Allergy and Clinical Immunology (2018)