tbuckley/cabot-search huggingface dataset:
Helen Alexandra Breen
Authors: Jean Sandra Wilson
Journal: BMJ (2017)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Helen Alexandra Breen Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Effect of Carcinogens on Small Organisms. III. Cell-Division Rate and Population Levels of Methylcholanthrene-Adapted Paramecia
Authors: R. R. Spencer, M. B. Melroy
Journal: JNCI Journal of the National Cancer Institute (1941)

Journal Article Effect of Carcinogens on Small Organisms. III. Cell-Division Rate and Population Levels of Methylcholanthrene-Adapted Paramecia Get access R. R. Spencer, R. R. Spencer assistant chief Search for other works by this author on: Oxford Academic PubMed Google Scholar M. B. Melroy M. B. Melroy assistant bacteriologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 2, October 1941, Pages 185–191, https://doi.org/10.1093/jnci/2.2.185 Published: 01 October 1941
The effect of antiviral therapy on clinical outcome of HCV cirrhosis with portal hypertension: a prospective cohort study.
Authors: Pier Luigi Almasio, Donatella Ferraro, Vito Di Marco, Vincenza Calvaruso, Stefania De Lisi, Pietro Parisi, Di Marco, Almasio Pl, De Lisi S, Calvaruso, Ferraro D, Peralta S, Parisi P, Alaimo G, Alessi N, Di Stefano R, Crax A
Journal: Hepatology (2006)
Opioid Should Come Off the Market
Authors: Rebecca Voelker
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of the Difference in Body Mass Index at Transplantation from That at Diagnosis for Graft-Versus-Host Disease-Free, Relapse-Free Survival in Acute Myeloid Leukemia
Authors: Taiki Ando, Etsuko Yamazaki, Haruka Teshigawara, Eriko Ogusa, Yoshimi Ishii, Kazuho Miyashita, Kenji Motohashi, Takuya Miyazaki, Takayoshi Tachibana, Maki Hagihara, Kenji Matsumoto, Masatsugu Tanaka, Chizuko Hashimoto, Hideyuki Koharazawa, Katsumichi Fujimaki, Jun Taguchi, Hiroyuki Fujita, Heiwa Kanamori, Shin Fujisawa, Hideaki Nakajima
Journal: Blood (2016)
Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance Data Published Between April 1, 2016 and January 31, 2017 — United States
Authors: Kimberly Thomas, Ruth Jajosky, Ralph J. Coates, Geoffrey M. Calvert, Daniel Dewey-Mattia, Jaime Raymond, Simple D. Singh
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

The Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance Data Published Between April 1, 2016 and January 31, 2017 - United States, herein referred to as the Summary (Noninfectious), contains official statistics for nationally notifiable noninfectious conditions and disease outbreaks. This Summary (Noninfectious) is being published in the same volume of MMWR as the annual Summary of Notifiable Infectious Diseases and Conditions (1). Data on notifiable noninfectious conditions and disease outbreaks from prior years have been published previously (2,3).
Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
Authors: Ke Chen, Weikun Qian, Zhengdong Jiang, Liang Cheng, Jie Li, Liankang Sun, Cancan Zhou, Luping Gao, Meng Lei, Bin Yan, Junyu Cao, Wanxing Duan, Qingyong Ma
Journal: Molecular Cancer (2017)

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer preventive and therapeutic effects of metformin, one of the most widely prescribed medications for type 2 diabetes mellitus. However, its role in pancreatic cancer is not fully elucidated. Herein, we aimed to further study the preventive and therapeutic effects of metformin in genetically engineered mouse models of pancreatic cancer. LSL-KrasG12D/+; Pdx1-Cre (KC) mouse model was established to investigate the effect of metformin in pancreatic tumorigenesis suppression; LSL-KrasG12D/+; Trp53fl/+; Pdx1-Cre (KPC) mouse model was used to evaluate the therapeutic efficiency of metformin in PDAC. Chronic pancreatitis was induced in KC mice by peritoneal injection of cerulein. Following metformin treatment, pancreatic acinar-to-ductal metaplasia (ADM) and mouse pancreatic intraepithelial neoplasia (mPanIN) were decreased in KC mice. Chronic pancreatitis induced a stroma-rich and duct-like structure and increased the formation of ADM and mPanIN lesions, in line with an increased cytokeratin 19 (CK19)-stained area. Metformin treatment diminished chronic pancreatitis-mediated ADM and mPanIN formation. In addition, it alleviated the percent area of Masson's trichrome staining, and decreased the number of Ki67-positive cells. In KPC mice, metformin inhibited tumor growth and the incidence of abdominal invasion. More importantly, it prolonged the overall survival. Metformin inhibited pancreatic cancer initiation, suppressed chronic pancreatitis-induced tumorigenesis, and showed promising therapeutic effect in PDAC.
Is Pediatric Long-term Care the Next Frontier in Infection Prevention and Control?
Authors: Joanna Thomson, Samir S. Shah
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
A novel prognostic model for transplant-free survival in primary sclerosing cholangitis
Authors: Elisabeth M de Vries, Junfeng Wang, Kate D Williamson, Mariska M Leeflang, Kirsten Boonstra, Rinse K Weersma, Ulrich Beuers, Roger W Chapman, Ronald B Geskus, Cyriel Y Ponsioen
Journal: Gut (2017)

Objective Most prognostic models for primary sclerosing cholangitis (PSC) are based on patients referred to tertiary care and may not be applicable for the majority of patients with PSC. The aim of this study was to construct and externally validate a novel, broadly applicable prognostic model for transplant-free survival in PSC, based on a large, predominantly population-based cohort using readily available variables. Design The derivation cohort consisted of 692 patients with PSC from the Netherlands, the validation cohort of 264 patients with PSC from the UK. Retrospectively, clinical and biochemical variables were collected. We derived the prognostic index from a multivariable Cox regression model in which predictors were selected and parameters were estimated using the least absolute shrinkage and selection operator. The composite end point of PSC-related death and liver transplantation was used. To quantify the models’ predictive value, we calculated the C-statistic as discrimination index and established its calibration accuracy by comparing predicted curves with Kaplan-Meier estimates. Results The final model included the variables: PSC subtype, age at PSC diagnosis, albumin, platelets, aspartate aminotransferase, alkaline phosphatase and bilirubin. The C-statistic was 0.68 (95% CI 0.51 to 0.85). Calibration was satisfactory. The model was robust in the sense that the C-statistic did not change when prediction was based on biochemical variables collected at follow-up. Conclusion The Amsterdam-Oxford model for PSC showed adequate performance in estimating PSC-related death and/or liver transplant in a predominantly population-based setting. The transplant-free survival probability can be recalculated when updated biochemical values are available.
ONC212 Is a Potent Member of the Imipridone Class of Anti-Cancer Compounds That Induces p53-Independent Apoptosis in Hematological Malignancies
Authors: Takenobu Nii, Jo Ishizawa, Ran Zhao, Jianfang Zeng, Dhruv Chachad, Kensuke Kojima, Marina Konopleva, Richard Eric Davis, Joshua E Allen, Martin Stogniew, Michael Andreeff
Journal: Blood (2016)
Management of a rare cause of significant acute upper gastrointestinal bleeding: gastric lipoma resected by hybrid endoscopic submucosal dissection
Authors: Nikolaos Koukias, Alberto Murino, Andrea Telese, Laura Gaeta, Niall Power, Michael Rathbone, Edward Despott
Journal: Endoscopy (2017)

Gastric lipomas are rare, benign, slow-growing subepithelial tumors. Most lipomas remain asymptomatic and are detected incidentally at endoscopy. Large lipomas, however, may very rarely cause significant upper gastrointestinal (GI) bleeding and warrant removal [1].
Monodispersed Bioactive Glass Nanoclusters with Ultralarge Pores and Intrinsic Exceptionally High miRNA Loading for Efficiently Enhancing Bone Regeneration
Authors: Yumeng Xue, Yi Guo, Meng Yu, Min Wang, Peter X. Ma, Bo Lei
Journal: Advanced Healthcare Materials (2017)

Abstract Bioactive glass nanoparticles (BGNs) have attracted much attention in drug delivery and bone tissue regeneration, due to the advantages including biodegradation, high bone‐bonding bioactivity, and facile large‐scale fabrication. However, the wide biomedical applications of BGNs such as efficient gene delivery are limited due to their poor pore structure and easy aggregation. Herein, for the first time, this study reports novel monodispersed bioactive glass nanoclusters (BGNCs) with ultralarge mesopores (10–30 nm) and excellent miRNA delivery for accelerating critical‐sized bone regeneration. BGNCs with different size (100–500 nm) are fabricated by using a branched polyethylenimine as the structure director and catalyst. BGNCs show an excellent apatite‐forming ability and high biocompatibility. Importantly, BGNCs demonstrate an almost 19 times higher miRNA loading than those of conventional BGNs. Additionally, BGNCs–miRNA nanocomplexes exhibit a significantly high antienzymolysis, enhance cellular uptake and miRNA transfection efficiency, overpassing BGNs and commercial Lipofectamine 3000. BGNCs‐mediated miRNA delivery significantly improves the osteogenic differentiation of bone marrow stromal stem cells in vitro and efficiently enhances bone formation in vivo. BGNCs can be a highly efficient nonviral vector for various gene therapy applications. The study may provide a novel strategy to develop highly gene‐activated bioactive nanomaterials for simultaneous tissue regeneration and disease therapy.
High-dose a randomized antithrombin III in severe sepsis - A randomized controlled trial.
Authors: B Waren, A Eid, P Singer, S Pillay, P Carl, Ivan Novak, Pavel Chalupa, A Atherstone, I Penzes, A Kübler, S Knaub, H-O Keinecke, H Heinrichs, F Schindel, M Juers, RC Bone, SM Opal
Journal: JAMA (2001)
Wound healing in epidermolysis bullosa
Authors: L. Bruckner‐Tuderman, J.E. Mellerio
Journal: British Journal of Dermatology (2017)

Epidermolysis bullosa (EB) is a group of inherited diseases characterised by recurrent skin blistering due to impaired epidermal or dermo-epidermal adhesion. In some subtypes, damage to internal organs causes serious comorbidities, and an increased risk of early and aggressive squamous cell carcinoma (SCC) characterizes recessive dystrophic EB (RDEB). It is likely that EB will only be cured by mutation-correction interventions, but until that goal becomes a reality we need to pool and extend knowledge about wound management and other strategies to improve quality of life for people with EB.

This article is protected by copyright. All rights reserved.
Minimal Residual Disease (MRD) Status in FCR-Treated CLL Patients at the End of Treatment Influences Progression Free Survival (PFS), Results of the Ctrial-IE (ICORG) 07-01/ CLL Ireland Study, with Mutational Analysis Providing Additional Insight
Authors: Niamh Appleby, Fiona M Quinn, David O'Brien, Smyth Liam, Johanna Kelly, Imelda Parker, Kathleen Scott, Mary R Cahill, Gerard Crotty, Helen Enright, Brian Hennessy, Andrew Hodgson, Maeve Leahy, Hilary M O'Leary, Michael E O'Dwyer, Amjad Hayat, Elisabeth A. Vandenberghe
Journal: Blood (2016)
Diary of a First-Year Doctoring Student
Authors: Alicia I. Rolin
Journal: Annals of Internal Medicine (2017)

Ad Libitum18 July 2017Diary of a First-Year Doctoring StudentAlicia I. RolinAlicia I. RolinFrom Providence, Rhode Island.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-2523 Audio Reading - “Diary of a First-Year Doctoring Student” Audio. Virginia L. Hood, MD, Annals Associate Editor, reads "Diary of a First-Year Doctoring Student," by A.I. Rolin. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail SeptemberHands clammy, I put the stethoscope in my ears. Backwards. Blushing, I try again. While I hear no heartbeat, I know without a doubt that the patient is alive—she is happily talking to me as I stare at my stethoscope in confusion. I cannot tell if the issue is with my set up of the instrument or my positioning on the body.To the man who tells me he has only had sex with ... Author, Article, and Disclosure InformationAffiliations: From Providence, Rhode Island.Current Author Addresses: Alicia I. Rolin, Warren Alpert Medical School, Brown University, 222 Richmond Street, Providence, RI 02903; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “Diary of a First-Year Doctoring Student” Audio. Virginia L. Hood, MD, Annals Associate Editor, reads "Diary of a First-Year Doctoring Student," by A.I. Rolin. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 18 July 2017Volume 167, Issue 2Page: 140KeywordsBlood pressureChildrenEmotionsFemale contraceptionHand strengthNervesPregnancyStomachSystematic reviewsThorax ePublished: 18 July 2017 Issue Published: 18 July 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Topical Corticosteroid Phobia in Atopic Dermatitis
Authors: Alvin W. Li, Emily S. Yin, Richard J. Antaya
Journal: JAMA Dermatology (2017)

Topical corticosteroid (TCS) phobia refers to the negative feelings and beliefs related to TCSs experienced by patients and patients' caregivers. This phenomenon may be a major contributing factor in treatment failure in patients with atopic dermatitis, yet it has been sparsely described in the literature.To systematically assess the nomenclature, prevalence, origins, and effect on treatment adherence of TCS phobia in atopic dermatitis.A literature search was conducted using specific eligibility criteria across electronic databases, including Ovid (MEDLINE, EMBASE), PubMed, and Web of Science, for articles published from January 1, 1946, to October 31, 2016. Included articles must have assessed TCS phobia in patients with atopic dermatitis or their caregivers. Quality ratings of studies were based on a modified version of the Oxford Centre for Evidence-Based Medicine quality rating scheme for individual studies.Of the 490 articles identified by literature search, 16 met the eligibility criteria. All studies were cross-sectional. Topical corticosteroid phobia prevalence ranged from 21.0% (95% CI, 15.8%-26.2%) to 83.7% (95% CI, 81.9%-85.5%). There was significant variation in how phobia was defined, ranging from concern to irrational fear. Questionnaires used to assess for TCS phobia included 1 to 69 questions. In the 2 studies that compared nonadherence between a phobia group and a nonphobia group, patients in both phobia groups were found to have a significantly higher rate of nonadherence (49.4% vs 14.1% and 29.3% vs 9.8%). The sources from which patients were receiving information about corticosteroids included physicians, friends and relatives, broadcast media, print media, and the internet.Features of TCS phobia are commonly reported by patients across cultures and may be associated with a higher rate of nonadherence. Patients with TCS phobia and the sources from which patients are receiving information about corticosteroids may be targetable for intervention to increase adherence to treatment regimens. The nomenclature and assessment methods for TCS phobia used in studies, however, lack standardization, precluding quantitative comparison and extrapolation of data. Additional research, using standardized definitions and methods of assessment, is needed to better characterize this phenomenon and evaluate the efficacy of potential interventions.
Abstract 14863: Iron Overload May be a Novel Risk Factor for Long-term Progression of Coronary Atherosclerosis
Authors: Keisuke Yasumura, Masami Nishino, Naotaka Okamoto, Akihiro Tanaka, Naoki Mori, Daisuke Nakamura, Masamichi Yano, Nobuhiko Makino, Yasuyuki Egami, Ryu Shutta, Jun Tanouchi
Journal: Circulation (2016)

Background: Iron deficiency is reported to be associated with poor quality of life, impaired exercise tolerance, and mortality independent of hematopoietic effects in the patient with heart failure...
Patient care is at risk from inadequate handovers, GMC finds
Authors: Abi Rimmer
Journal: BMJ (2017)

Patient care at hospitals in the East Midlands is potentially at risk because of inadequate handovers between teams of doctors, a General Medical Council review has found.1

On 19 July the GMC published a report on medical education and training throughout the East Midlands after visits to five local education providers, two medical schools, and Health Education England’s local office in the region from October to December 2016. At the time around 3013 doctors were training in the East Midlands, the report found.

It said that trainees at Sherwood Forest Hospitals NHS Trust and United Lincolnshire Hospitals NHS Trust had told the GMC that handovers at the trusts lacked continuity of care and may be unsafe for patients.

“At both Pilgrim Hospital and …
Abstract 329: The Human Pericardial Fluid is Enriched With Cardiovascular-expressed Micrornas and Exosomes Able to Elicit Therapeutic Responses
Authors: Cristina Beltrami, Saran Shantikumar, Andrew Shearn, Abas Laftha, Cha Rajakaruna, Gianni D Angelini, Costanza Emanueli
Journal: Circulation Research (2015)

Cells release functionally active microRNAs (miRs) into extracellular vesicles (EVs: exosomes and microparticles). In vitro, EVs shuttle miRs and other molecules between cells. The functional relevance of EVs in the context of human physiopathology is still debated. We hypothesize that the pericardial fluid (PF) mediates myocardium cell-to-cell communication through EVs exchanges. Here, we aimed to (1) characterize human PF EVs and exosomal miRs; (2) investigate if PF EVs exert a biological function. PF, plasma, thoracic aorta (TA) and right atrium appendage (RAA) samples were collected as leftovers from aortic valve replacement surgery. A miR array identified PF miRs expression. The top expressed cardiovascular miRs were measured (RT-qPCR) in TA and RAA (to validate expression in patients cardiovascular tissues), PF and plasma, and exosomes enriched from PF and plasma. EVs concentration and size distribution in PF and plasma were quantified by a nanoparticle tracking analysis system. The exosome functional activity was tested in human endothelial cells (ECs) and in a mouse model of limb ischemia (LI). A pool of cardiovascular miRs (including miR-21 and -29a), were enriched in the PF in comparison to plasma, suggesting that the PF/plasma concentration gradients of cardiovascular miRs were caused by the trafficking of these miRs from the myocardium and thoracic vessels to the PF. This gradient was reverted for the negative control miR-122 (produced by the liver and undetectable in the PF). Exosomes were abundant in the PF, even if less concentrated than in plasma. PF-exosome treatment of ECs exposed to hypoxia significantly decreased cell apoptosis and increased cell proliferation (P&lt;0.01 vs PBS). Local PF-exosomes delivery increased post-LI ischemic blood flow recovery (P&lt;0.01 vs PBS). By contrast, plasma-exosomes were not effective (P=NS vs PBS). We have provided the first characterization of EVs and exosomal miRs in the human PF and for first identified a therapeutic potential of PF- exosomes from cardiovascular patients. Future studies will be tailored to exploit the properties PF-exosome in regenerative medicine.
John Moorhouse Heaton
Authors: Miles Clapham
Journal: BMJ (2017)

John Moorhouse Heaton started his professional life as an ophthalmologist. He spent two years in the Royal Air Force as a medical officer and became acting squadron leader. He introduced an innovative psychological treatment for pilots with stress induced eye strain. His first book was The Eye (1968), on the phenomenology of vision.

After 10 years in …