tbuckley/cabot-search huggingface dataset:
Metastatic Calcinosis Cutis Associated With a Selective FGFR Inhibitor
Authors: David R. Carr, Llana Pootrakul, Hui-Zi Chen, Catherine G. Chung
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Androgen Receptor Expression and Breast Cancer Survival: Results From the Nurses’ Health Studies
Authors: Kevin H Kensler, Elizabeth M Poole, Yujing J Heng, Laura C Collins, Benjamin Glass, Andrew H Beck, Aditi Hazra, Bernard A Rosner, A Heather Eliassen, Susan E Hankinson, Eric P Winer, Myles Brown, Rulla M Tamimi
Journal: JNCI Journal of the National Cancer Institute (2018)

Abstract Background Hormone receptor signaling is critical in the progression of breast cancers, although the role of the androgen receptor (AR) remains unclear, particularly for estrogen receptor (ER)–negative tumors. This study assessed AR protein expression as a prognostic marker for breast cancer mortality. Methods This study included 4147 pre- and postmenopausal women with invasive breast cancer from the Nurses’ Health Study (diagnosed 1976–2008) and Nurses’ Health Study II (1989–2008) cohorts. AR protein expression was evaluated by immunohistochemistry and scored through pathologist review and as a digitally quantified continuous measure. Hazard ratios (HR) and 95% confidence intervals (CI) of breast cancer mortality were estimated from Cox proportional hazards models, adjusting for patient, tumor, and treatment covariates. Results Over a median 16.5 years of follow-up, there were 806 deaths due to breast cancer. In the 7 years following diagnosis, AR expression was associated with a 27% reduction in breast cancer mortality overall (multivariable HR = 0.73, 95% CI = 0.58 to 0.91) a 47% reduction for ER+ cancers (HR = 0.53, 95% CI = 0.41 to 0.69), and a 62% increase for ER− cancers (HR = 1.62, 95% CI = 1.18 to 2.22) (P heterogeneity &lt; .001). A log-linear association was observed between AR expression and breast cancer mortality among ER− cancers (HR = 1.14, 95% CI = 1.02 to 1.26 per each 10% increase in AR), although no log-linear association was observed among ER+ cancers. Conclusions AR expression was associated with improved prognosis in ER+ tumors and worse prognosis in ER− tumors in the first 5–10 years postdiagnosis. These findings support the continued evaluation of AR-targeted therapies for AR+/ER− breast cancers.
Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques
Authors: Matthew S. Parsons, Wen Shi Lee, Anne B. Kristensen, Thakshila Amarasena, Georges Khoury, Adam K. Wheatley, Arnold Reynaldi, Bruce D. Wines, P. Mark Hogarth, Miles P. Davenport, Stephen J. Kent
Journal: Journal of Clinical Investigation (2018)

A considerable body of evidence suggests that Fc-dependent functions improve the capacity of broadly neutralizing antibodies (BnAbs) to protect against and control HIV-1 infection. This phenomenon, however, has not been formally tested in robust cell-associated macaque simian-human immunodeficiency virus (SHIV) models with newer-generation BnAbs. We studied both the WT BnAb PGT121 and a LALA mutant of PGT121 (which has impaired Fc-dependent functions) for their ability to protect pigtail macaques from an i.v. high-dose cell-associated SHIVSF162P3 challenge. We found that both WT and LALA PGT121 completely protected all 12 macaques studied. Further, partial depletion of NK cells, key mediators of Fc-dependent functions, did not abrogate the protective efficacy of PGT121 in 6 macaques. Additionally, in animals with established SHIVSF162P3 infection, SHIV viremia levels were equally rapidly reduced by LALA and WT PGT121. Our studies suggest that the potent neutralizing capacity of PGT121 renders the Fc-dependent functions of the Ab at least partially redundant. These findings have implications for Ab-mediated protection from and control of HIV-1 infection.
Reply
Authors: Erin M. Wilfong, Kevin W. Bayram, Leslie J. Crofford
Journal: Arthritis & Rheumatology (2018)

Arthritis & RheumatologyVolume 71, Issue 4 p. 652-653 Letters Reply Erin M. Wilfong MD, PhD, Corresponding Author Erin M. Wilfong MD, PhD erin.m.wilfong@vumc.org orcid.org/0000-0002-6584-1578 Vanderbilt University Medical Center Nashville, TN and University of California San FranciscoSearch for more papers by this authorKevin W. Bayram MD, Kevin W. Bayram MD Vanderbilt University Medical Center, Nashville, TNSearch for more papers by this authorLeslie J. Crofford MD, Leslie J. Crofford MD Vanderbilt University Medical Center, Nashville, TNSearch for more papers by this author Erin M. Wilfong MD, PhD, Corresponding Author Erin M. Wilfong MD, PhD erin.m.wilfong@vumc.org orcid.org/0000-0002-6584-1578 Vanderbilt University Medical Center Nashville, TN and University of California San FranciscoSearch for more papers by this authorKevin W. Bayram MD, Kevin W. Bayram MD Vanderbilt University Medical Center, Nashville, TNSearch for more papers by this authorLeslie J. Crofford MD, Leslie J. Crofford MD Vanderbilt University Medical Center, Nashville, TNSearch for more papers by this author First published: 19 November 2018 https://doi.org/10.1002/art.40782Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume71, Issue4April 2019Pages 652-653 RelatedInformation
Novel Techniques in the Surgical Management of Hepatocellular Carcinoma
Authors: Vasileia Ntomi, Anna Paspala, Dimitrios Schizas
Journal: Liver Cancer (2018)

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with cirrhosis preceding its development in most cases. Surgical resection remains the primary therapeutic option despite the recent emergence of locoregional therapies. Novel surgical techniques are being proposed to overcome the limitations of traditional anatomical open liver resection. Laparoscopic resection is a safe and effective alternative to open liver resection, especially for left lateral or peripheral segment tumors. It is associated with less postoperative morbidity, intraoperative blood loss, and medial hospital stay with no difference in oncological outcomes. Robotic-assisted liver resection overcomes the technically difficult resection of tumors located at the posterosuperior segments with similar outcomes to laparoscopic resection. Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure allows resection in patients with HCC, and associated major vascular resection or small future liver remnant (FLR) with long-term results yet to be announced. For patients with small solitary tumors or poor liver function, nonanatomical liver resection is a feasible therapeutic option due to minimal postoperative morbidity and similar oncological results of anatomical resection.
Tobacco Use in the Myeloproliferative Neoplasms: Patient Behavior, Opinions, and Care
Authors: Robyn M. Scherber, Holly L. Geyer, Gina Mazza, Blake T. Langlais, Amylou C. Dueck, Jeanne Palmer, Leslie Padrnos, Angela Fleischman, Ruben A. Mesa
Journal: Blood (2018)
Current Results of Lentiglobin Gene Therapy in Patients with Severe Sickle Cell Disease Treated Under a Refined Protocol in the Phase 1 Hgb-206 Study
Authors: John F. Tisdale, Julie Kanter, Markus Y. Mapara, Janet L. Kwiatkowski, Lakshmanan Krishnamurti, Manfred Schmidt, Alexandra L. Miller, Francis J. Pierciey, Weiliang Shi, Jean-Antoine Ribeil, Mohammed Asmal, Alexis A. Thompson, Mark C. Walters
Journal: Blood (2018)
Overall Survival in Acquired Pure Red Cell Aplasia in Adults Following Immunosuppressive Therapy: Preliminary Results from the Nationwide Cohort Study (PRCA2016)
Authors: Naohito Fujishima, Makoto Hirokawa, Kenichi Sawada, Shinji Nakao, Yuji Yonemura, Akira Matsuda, Norio Komatsu, Hideo Harigae, Akiko Saito, Kaoru Tohyama, Itaru Matsumura, Mineo Kurokawa, Shunya Arai, Kinuko Mitani
Journal: Blood (2018)
Evaluation of Endocrine Complications in Beta-Thalassemia Intermedia Patients: A Cross Sectional Multi-Center Study
Authors: Mehran Karimi, Tahereh Zarei, Sezaneh Haghpanah, Azita Azarkeivan, Christos Kattamis, Vassilis Ladis, Yurdanur Kilinc, Shahina Daar, Saif Alyaarubi, Duaa Yasseen, Mohamed A Yassin, Ashraf Tawfiq Soliman, Duran Canatan, Maha Obiedat, Hala Remawi, Demetris Mariannis, Constantinos Christodoulides, Soteroula Christou, Ploutarchos Tzoulis, Vincenzo De Sanctis
Journal: Blood (2018)
Airway microbiome in adult survivors of extremely preterm birth: the EPICure study
Authors: Sylvia A.D. Rofael, Timothy D. McHugh, Rachael Troughton, Joanne Beckmann, David Spratt, Neil Marlow, John R. Hurst
Journal: European Respiratory Journal (2018)

Bronchopulmonary dysplasia (BPD) is a major complication of preterm birth that leads to lifelong respiratory morbidity. The EPICure study has investigated the longitudinal health outcomes of infants born extremely preterm (EP; <26 weeks gestation). Our aim was to characterise the airway microbiome in young adults born extremely preterm, with and without neonatal BPD, in comparison to matched term-born controls.Induced sputum was collected from 92 young adults aged 19 years (51 EP and 41 controls). Typical respiratory pathogens were detected using quantitative PCR. 16S rRNA gene sequencing was completed on 74 samples (29 EP with BPD; 9 EP without BPD; and 36 controls).The preterm group with BPD had the least diverse bacterial communities. The relative abundance of Bacteriodetes, particularly Prevotella melaninogenica was significantly lower in the preterm group compared to controls. This decline was balanced by a nonsignificant increase in Firmicutes. Total Prevotella relative abundance correlated with forced expiratory volume in 1 s z-score (ρ=0.272; p<0.05). Typical respiratory pathogen loads and prevalence were similar between groups.In conclusion, extremely preterm birth is associated with a significant dysbiosis in airway microbiome in young adulthood regardless of neonatal BPD status. This is characterised by a shift in the community composition away from Bacteriodetes as manifested in a significant drop in Prevotella relative abundance.
Arbovirus surveillance: first dengue virus detection in local Aedes albopictus mosquitoes in Europe, Catalonia, Spain, 2015
Authors: Carles Aranda, Miguel J. Martínez, Tomas Montalvo, Roger Eritja, Jessica Navero-Castillejos, Eva Herreros, Eduard Marqués, Raúl Escosa, Irene Corbella, Esther Bigas, Lluís Picart, Mireia Jané, Irene Barrabeig, Núria Torner, Sandra Talavera, Ana Vázquez, Mari Paz Sánchez-Seco, Núria Busquets
Journal: Eurosurveillance (2018)

Dengue has emerged as the most important viral mosquito-borne disease globally. The current risk of dengue outbreaks in Europe appeared with the introduction of the vector Aedes albopictus mosquito in Mediterranean countries. Considering the increasing frequency of dengue epidemics worldwide and the movement of viraemic hosts, it is expected that new autochthonous cases will occur in the future in Europe. Arbovirus surveillance started in Catalonia in 2015 to monitor imported cases and detect possible local arboviral transmission. During 2015, 131 patients with a recent travel history to endemic countries were tested for dengue virus (DENV) and 65 dengue cases were detected. Twenty-eight patients with a febrile illness were viraemic, as demonstrated by a positive real-time RT-PCR test for DENV in serum samples. Entomological investigations around the viraemic cases led to the detection of DENV in a pool of local Ae. albopictus captured in the residency of one case. The sequence of the DENV envelope gene detected in the mosquito pool was identical to that detected in the patient. Our results show how entomological surveillance conducted around viraemic travellers can be effective for early detection of DENV in mosquitoes and thus might help to prevent possible autochthonous transmission.
Efficacy of regorafenib in metastatic colorectal cancer: A multi-institutional retrospective study
Authors: M.S. Bazarbashi, M.A. Elshenawy, M.S. Kandil, M. Zahir, A. Shaheen, A. Gad, O. Alshaer, A.M. Alzahrani, A. Eldali, A. Aljubran
Journal: Annals of Oncology (2018)
Reply to ‘Selective effects of heterozygous protein-truncating variants’
Authors: Christopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan, David Nusinow, Kaitlin E. Samocha, Anne O’Donnell-Luria, Daniel G. MacArthur, Mark J. Daly, David R. Beier, Shamil R. Sunyaev
Journal: Nature Genetics (2018)
Epidemiological changes of acute/recent human immunodeficiency virus type 1 infection in Barcelona, Spain (1997–2015): a prospective cohort study
Authors: D. Nicolás, J. Ambrosioni, E. de Lazzari, A. Suarez, C. Manzardo, F. Agüero, M.M. Mosquera, J. Costa, C. Ligero, M.Á. Marcos, S. Sánchez-Palomino, E. Fernández, M. Plana, S. Yerly, J.M. Gatell, J.M. Miró
Journal: Clinical Microbiology and Infection (2018)
Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability
Authors: Zhaomeng Wang, Mengchi Sun, Tian Liu, Zisen Gao, Qing Ye, Xiao Tan, Yanxian Hou, Jin Sun, Dun Wang, Zhonggui He
Journal: Asian Journal of Pharmaceutical Sciences (2018)

Co-amorphous solid dispersion (C-ASD) systems have attracted great attention to improve the solubility of poorly soluble drugs, but the selection of an appropriate stabilizer to stabilize amorphous forms is still a huge challenge. Herein, C-ASD system of two clinical combined used drugs (lacidipine (LCDP) and spironolactone (SPL)) as stabilizers to each other, was prepared by solvent evaporation method. The effects of variation in molar ratio of LCDP and SPL (3:1, 1:1, 1:3, 1:6, and 1:9) on the drug release characteristics were explored. Polarized light microscopy (PLM), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were employed to evaluate the solid states. Prepared C-ASDs were further studied for their stability under the high humidity (RH 92.5%). Further analysis of C-ASDs via Fourier-transform infrared spectroscopy (FTIR) and Raman spectroscopy confirmed that hydrogen bond interactions between the two drugs played a significant role in maintaining the stability of the C-ASDs systems. Moreover, molecular dynamic (MD) simulations provided a clear insight into the stability mechanism at the molecular level. This study demonstrated the novel drug-drug C-ASDs systems is a promising formulation strategy for improved dissolution rate and enhanced physical stability of poorly soluble drugs.
Oncogenic-Drivers Dictate Immune Responses to Control Disease Progression in Acute Myeloid Leukaemia
Authors: Rebecca Austin, Megan Bywater, Jasmin Straube, Leanne T Cooper, Madeleine Headlam, Keyur Dave, Matthias Braun, Tobias Bald, Fernando Guimaraes, Sebastien Jacquelin, Matthew Witkowski, Iannis Aifantis, Geoffrey R Hill, Mark J Smyth, Steven W. Lane
Journal: Blood (2018)
Cisplatin and pemetrexed synergises with immunotherapy to result in cures in established murine malignant mesothelioma
Authors: Anna Nowak, Sathish Mahendran, Robbert van der Most, Richard Lake
Journal: Cancer Research (2008)

2073  The aim of this study is to evaluate the contribution of intact adaptive cellular immunity to pemetrexed cytotoxicity and the efficacy of combining pemetrexed and cisplatin with immunotherapy with CD40 activation in a murine model of malignant mesothelioma. We previously demonstrated synergy between the nucleoside analogue gemcitabine and immunotherapy in small tumors. Pemetrexed is an antimetabolite with multiple targets in the folate metabolism pathway. The murine mesothelioma cell line AB1-HA was originally generated through peritoneal asbestos inoculation and transfected with the hemagglutinin (HA) neo-antigen to allow analysis of antigen-specific anti-tumor responses using CD4+ or CD8+ lymphocytes from HA-specific TCR transgenic mice. In vitro growth inhibition was assessed by MTT assays. In vivo tumor growth was assessed using a subcutaneous flank model in athymic nude and wild-type (wt) BALB/c mice. Chemotherapy was given i.p. at the MTD previously determined (gemcitabine 120 μg/g 3rd daily x 5; cisplatin 4μg/g q7d x 3 and pemetrexed 60 μg/g days 1-3 q7d). FGK 45 (activating anti-CD40 antibody) was given 3 times 100μg i.v. starting 2 days after the end of chemotherapy. AB1-HA was approximately 5-fold more sensitive to gemcitabine than pemetrexed in vitro. In vivo in athymic nude mice, gemcitabine decreased tumor outgrowth as compared with untreated control mice (p
GMC checks 3000 doctors’ credentials after fraudulent psychiatrist practised for 23 years
Authors: Clare Dyer
Journal: BMJ (2018)

The General Medical Council is urgently reviewing the qualifications of around 3000 doctors after it emerged that a psychiatrist was able to practise for 23 years in the UK with fraudulent credentials.

Zholia Alemi joined the UK medical register in 1992 under an exemption that allowed certain graduates from British Commonwealth countries to obtain registration on the basis of their qualification without having to pass the standard, two part assessment of their medical knowledge and skills, the Professional and Linguistic Assessment Board exam.

Alemi presented what appeared to be a primary medical qualification from the University of Auckland in New Zealand, a letter from the university confirming her graduation, and a reference …
Abstract 18991: Exploitation of Exosomes for Myoangigenesis
Authors: Min Gong, Min Wang, Jiapeng Wang, Yigang Wang, Muhammad Ashraf, Meifeng Xu
Journal: Circulation (2017)

Background: It is well known that exosomes (EXO) play an important role in cell-cell communication and cellular functions. We hypothesized that specific myoangiogenic miRs (e.g. miR-30a) can be con...
Association of Interpersonal Violence With Women’s Health
Authors: Rebecca C. Thurston, Elizabeth Miller
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Folate-dactolisib conjugates for targeting tubular cells in polycystic kidneys
Authors: Haili Shi, Wouter N. Leonhard, Niels J. Sijbrandi, Mies J. van Steenbergen, Marcel H.A.M. Fens, Joep B. van de Dikkenberg, Javier Sastre Toraño, Dorien J.M. Peters, Wim E. Hennink, Robbert Jan Kok
Journal: Journal of Controlled Release (2018)

The aim of the present study was to develop folic acid (FA) conjugates which can deliver the kinase inhibitor dactolisib to the kidneys via folate receptor-mediated uptake in tubular epithelial cells. Dactolisib is a dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) and is considered an attractive agent for treatment of polycystic kidney disease. The ethylenediamine platinum(II) linker, herein called Lx, was employed to couple dactolisib via coordination chemistry to thiol-containing FA-spacer adducts to yield FA-Lx-dactolisib conjugates. The dye lissamine was coupled via similar linker chemistry to folate to yield fluorescent FA-Lx-lissamine conjugates. Three different spacers (PEG5-Cys, PEG27-Cys or an Asp-Arg-Asp-Asp-Cys peptide spacer) were used to compare the influence of hydrophilicity and charged groups in the spacer on interaction with target cells and in vivo organ distribution of the final conjugates. The purity and identity of the final products were confirmed by UPLC and LC-MS analysis, respectively. FA-Lx-dactolisib conjugates were stable in serum and culture medium, while dactolisib was released from the conjugates in the presence of glutathione. All three type of conjugates were internalized efficiently by HK-2 cells and uptake could be blocked by an excess of folic acid in the medium, demonstrating FR mediated uptake. FA-Lx-dactolisib conjugates showed nanomolar inhibition of the PI3K pathway (Akt phosphorylation) and mTOR pathway (S6 phosphorylation) in cultured kidney epithelial cells (HK-2 cells). After intraperitoneal administration, all three types conjugates accumulated extensively in kidneys of iKsp-Pkd1del mice with polycystic kidney disease. In conclusion, folate conjugates were successfully prepared by platinum(II) coordination chemistry and accumulated in a target-specific manner in kidney cells and polycystic kidneys. The folate conjugate of dactolisib thus may have potential for targeted therapy of polycystic kidney disease.
Petition against “cruel” and “ridiculous” guidance on access to medicinal cannabis attracts 400 000 signatures
Authors: Clare Dyer
Journal: BMJ (2018)

The parents of severely epileptic children have launched a campaign to try to get the strict new guidelines for the provision of medicinal cannabis revised after some found that doctors were reluctant to prescribe the recently legalised medication.

In a letter to the Times , the families of 12 children said that they still faced the “cruel and ridiculous” prospect of being forced to go abroad for treatment, even though cannabis based medication has been made legal in the UK after an earlier campaign.12

One of the signatories, Hannah Deacon, the mother of 6 year old Alfie Dingley, has gathered around 400 000 signatures on a new petition urging a …