tbuckley/cabot-search huggingface dataset:
Abstract 12485: Plasma Heparin Cofactor II Activities are Inversely Associated With Aberrant Glucose Metabolism in Humans and Mice
Authors: Ken-ichi Aihara, Sumiko Yoshida, Ryoko Uemoto, Kazue Ishikawa, Toshio Matsumoto
Journal: Circulation (2013)

Background:  Heparin cofactor II (HCII), a serine protease inhibitor, inactivates thrombin action. We previously showed that HCII is an antiatherogenic factor in humans and mice. In addition, we previously demonstrated that thrombin inactivation ameliorates insulin resistance in type 2 diabetic db/db mice. Therefore, we hypothesized that HCII is associated with glucose metabolism.   Methods and Results:  Plasma HCII activity and surrogate markers of glucose metabolism, including HbA1c, fasting plasma glucose (FPG) and homeostasis model assessment ratio (HOMA-R), were determined in elderly Japanese individuals (81 males and 69 females, mean age of 63.6 ± 10.7 years). Relationships between HCII and those surrogate markers were statistically evaluated after adjustment of age and sex. In addition, HCII+/- mice were fed normal or high-fat diet chow and analysed at the age of 25 weeks. There were significant inverse relationships between HCII and HbA1c value (r=0.246, p≤0.005), between HCII and FPG (r=0.203, p≤0.05) and between HCII and HOMA-R (r=0.167, p≤0.05). Moreover, HCII+/- mice fed a high-fat diet showed higher FPG (149.6 ± 11.2 vs 193.3 ± 8.2 mg/dl, p≤0.01) and HOMA-R (58.5 ± 8.1 vs 113.5 ± 27.7, p≤0.05) than those in HCII+/+ mice fed a high-fat diet. Gene expression levels of MCP-1, F4/80 and TNF-alpha were prominently increased in adipose tissue of HCII+/- mice compared to those in HCII+/+ mice.   Conclusions:  The present study demonstrated that heparin cofactor II is a novel regulating factor for glucose metabolism. Therefore, HCII may be a therapeutic target for diabetes as well as atherosclerotic diseases.
Traitement du diverticule de Zenker: comparaison rétrospective de la technique de la fenêtre par endoscopie souple et des approches chirurgicales
Authors: L Calavas, M Pioche, J Rivory, O Guillaud, JC Saurin, S Roman, T Ponchon
Journal: Endoscopy (2018)

Différentes options permettent de traiter un diverticule de Zenker (DZ) symptomatique, soit par cervicotomie, soit par endoscopie rigide ou souple. Au cours de l'endoscopie souple, nous utilisons une technique appelée la «technique de la fenêtre» pour optimiser le champ visuel. Notre étude a évalué cette technique au cours de l'endoscopie souple et comparé ces 3 approches.
Conditional Regulation of Gene Expression by Ligand-Induced Occlusion of a MicroRNA Target Sequence
Authors: Huihui Mou, Guocai Zhong, Matthew R. Gardner, Haimin Wang, Yi-Wen Wang, Dechun Cheng, Michael Farzan
Journal: Molecular Therapy (2018)

RNA switches that modulate gene expression with small molecules have a number of scientific and clinical applications. Here, we describe a novel class of small regulatory on switches based on the ability of a ligand-bound aptamer to promote stem formation between a microRNA target sequence (miR-T) and a complementary competing strand. Two on switch architectures employing this basic concept were evaluated, differing in the location of a tetracycline aptamer and the region of a miR-21 target sequence (miR-21-T) masked by its competing strand. Further optimizations of miR-21-T and its competing strand resulted in tetracycline-regulated on switches that induced luciferase expression by 19-fold in HeLa cells. A similar switch design based on miR-122-T afforded 7-fold regulation when placed in tandem, indicating that this approach can be extended to additional miR-T. Optimized on switches introduced into adeno-associated virus (AAV) vectors afforded 10-fold regulation of two antiviral proteins in AAV-transduced cells. Our data demonstrate that small-molecule-induced occlusion of a miR-T can be used to conditionally regulate gene expression in mammalian cells and suggest that regulatory switches built on this principle can be used to dose expression of an AAV transgene.
Pathogenicity and genetic characterisation of a novel reassortant, highly pathogenic avian influenza (HPAI) H5N6 virus isolated in Korea, 2017
Authors: Young-Il Kim, Young-Jae Si, Hyeok-Il Kwon, Eun-Ha Kim, Su-Jin Park, Norbert John Robles, Hiep Dinh Nguyen, Min-Ah Yu, Kwang-Min Yu, Youn-Jeong Lee, Myoung-Heon Lee, Young Ki Choi
Journal: Eurosurveillance (2018)

We investigated influenza A(H5N6) viruses from migratory birds in Chungnam and Gyeonggi Provinces, South Korea following a reported die-off of poultry in nearby provinces in November 2017. Genetic analysis and virulence studies in chickens and ducks identified our isolate from December 2017 as a novel highly pathogenic avian influenza virus. It resulted from reassortment between the highly virulent H5N8 strain from Korea with the N6 gene from a low-pathogenic H3N6 virus from the Netherlands.
Oregon’s Death With Dignity Act—Reply
Authors: Charles Blanke, Lee Ellis, Frank Meyskens
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Do All Patients Need β-Blockers After a Heart Attack?
Authors: Jennifer Abbasi
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of event-specific tertiles to analyse the relationship between serum androgens and athletic performance in women
Authors: Amanda Menier
Journal: British Journal of Sports Medicine (2018)

Bermon and Garnier1 summarised their recent findings by stating that in 5 of 21 events, ‘female athletes with high testosterone levels benefit from a 1.8% to 4.5% competitive advantage over other female competitors with normal androgen levels’. As the authors did not divide female athletes into comparison groups based on a value of free testosterone (fT) determined a priori to be ‘high’, the study’s design does not allow for this conclusion. Given the authors contextualise the study using the Court of Arbitration for Sport’s (CAS) suspension of the International Association …
A randomized, placebo-controlled pilot trial of armodafinil for fatigue in patients with gliomas undergoing radiotherapy.
Authors: Eudocia Quant Lee, Alona Muzikansky, Santosh Kesari, Eric T. Wong, Camilo E. Fadul, David A. Reardon, Andrew David Norden, Lakshmi Nayak, Mikael L. Rinne, Brian Michael Alexander, Nils D. Arvold, Lisa M. Doherty, Debra C. LaFrankie, Julee Pulverenti, Katrina H. Smith, Sarah C. Gaffey, Samantha Hammond, Jan Drappatz, Patrick Y. Wen
Journal: Journal of Clinical Oncology (2014)

2004 Background: Fatigue is a common symptom among glioma patients and affects quality of life. Armodafinil, a wakefulness-promoting medication, benefits patients with fatigue of various causes. This study evaluates the effects of armodafinil on fatigue in glioma patients undergoing radiation therapy (RT). Methods: Eligibility criteria included age ≥ 18; Karnofsky Performance Status (KPS) ≥ 60; grade 2-4 glioma undergoing RT to a total dose of 50-60 Gy with or without chemotherapy. Patients were randomized 1:1 to armodafinil (A) or placebo (P). Fatigue assessments were made at baseline, Day 22, Day 43, and Day 56 with the FACIT-F Fatigue Scale, Brief Fatigue Inventory (BFI), and Cancer Fatigue Scale (CFS). The primary aim is to detect a difference in the 42-day change in FACIT-F fatigue subscale scores between the two groups using a 2-sample Wilcoxon statistic. Secondary outcomes include a 42-day change in CFS and BFI. Results: Data is available for 77 of the 80 patients (40 in A and 37 in P). In the armodafinil arm, median age was 56 (25-79), median KPS was 90 (70-100), 57.5% had glioblastoma (GBM), 35% had anaplastic glioma (AG), 7.5% had another glioma histology. In the placebo arm, median age was 54 (19-78), median KPS was 90 (70-100), 51.4% had GBM, 32.4% had AG, and 16.2% had another glioma histology. The median 42-day change in the FACIT-F fatigue subscale scores in the armodafinil arm was 2 (range -40 to 26) and in the placebo arm was -6.665 (range -65 to 28) with Wilcoxon p-value of 0.066. There was a statistically significant improvement in fatigue in the armodafinil arm vs. the placebo arm based on median 42-day change in the BFI (Wilcoxon p-value of 0.008). Toxicity was rare and similar between arms. There were no cardiac toxicities attributed to treatment. One patient experienced insomnia in the armodafinil arm. Conclusions: Treatment with armodafinil is well tolerated in glioma patients undergoing RT. There is a trend towards fatigue reduction in the armodafinil group. Updated results will be presented. Study Sponsored by: Cephalon, Inc., a wholly owned subsidiary of Teva Pharmaceuticals, and the National Brain Tumor Society. Clinical trial information: NCT00766467.
Services Provided by Internal Medicine Physicians Compared With Emergency Physicians: Flawed Data
Authors: Rebecca Parker
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Plastome-wide comparison reveals new SNV resources for the authentication of Dendrobium huoshanense and its corresponding medicinal slice (Huoshan Fengdou)
Authors: Zhitao Niu, Jiajia Pan, Qingyun Xue, Shuying Zhu, Wei Liu, Xiaoyu Ding
Journal: Acta Pharmaceutica Sinica B (2018)

Dendrobium species and their corresponding medicinal slices have been extensively used as traditional Chinese medicine (TCM) in many Asian countries. However, it is extremely difficult to identify Dendrobium species based on their morphological and chemical features. In this study, the plastomes of D. huoshanense were used as a model system to investigate the hypothesis that plastomic mutational hotspot regions could provide a useful single nucleotide variants (SNVs) resource for authentication studies. We surveyed the plastomes of 17 Dendrobium species, including the newly sequenced plastome of D. huoshanense. A total of 19 SNVs that could be used for the authentication of D. huoshanense were detected. On the basis of this comprehensive comparison, we identified the four most informative hotspot regions in the Dendrobium plastome that encompass ccsA to ndhF, matK to 3'trnG, rpoB to psbD, and trnT to rbcL. Furthermore, to established a simple and accurate method for the authentication of D. huoshanense and its medicinal slices, a total of 127 samples from 20 Dendrobium species including their corresponding medicinal slices (Fengdous) were used in this study. Our results suggest that D. huoshanense and its medicinal slices can be rapidly and unequivocally identified using this method that combines real-time PCR with the amplification refractory mutation system (ARMS).
Abstract 12557: The Impact of Spinal Cord Injury and Exercise Training on Cerebrovascular Function: Preliminary Results
Authors: Dong-Il Kim, Matthew Lapointe, Jason W Hamner, J. Andrew Taylor, Can Ozan Tan
Journal: Circulation (2016)

Background: Spinal cord injured (SCI) individuals are at higher risk of cerebrovascular disease, including stroke, suggesting that they cannot maintain steady cerebral perfusion. This may be due to disruption of nervous vascular control and/or prolonged inactivity and consequent deconditioning. If inactivity plays a significant role, appropriate exercise may reverse this decline. However, the relation between SCI and cerebrovascular function, and the impact of exercise is not well established. Methods: We studied cerebral blood flow responses to progressive increases in arterial CO 2 (via rebreathing) in 9 individuals with SCI (C5 - T10, &gt;7 months post-injury). Vasoreactivity was derived from the relation between end-tidal CO 2 and cerebrovascular conductance. Five of the individuals were enrolled in 3-months hybrid-functional electrical stimulation-rowing exercise training program. Results: Vasoreactivity was somewhat lower in individuals with SCI compared to able-bodied controls (0.021±0.003 vs 0.030+0.009, p =0.28), and was related to the level of injury (R 2 =0.51, p =0.03), such that individuals with higher level injuries had lower vasoreactivity. Exercise training improved vasoreactivity (by ~25% overall), and the extent of improvement was strongly related to injury duration (R 2 =0.70, p =0.07) but not level (R 2 =0.06), such that longer injury duration was associated with a bigger improvement. Conclusions: Given that individuals with higher injuries are more inactive compared to those with lower injuries, these preliminary data suggest that the decline in cerebrovascular function after SCI may primarily be due to prolonged inactivity and may be reversed by appropriate exercise. These results may have implications for sustained physical inactivity and cumulative cerebrovascular risk in general population.
Abstract #LB-122: Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma
Authors: Xue Xiao, Gong Yang, Imelda Mercado-Uribe, Paul Chiao, Louis Dubeau, Jinsong Liu
Journal: Cancer Research (2009)

Epithelial ovarian cancers are a heterogeneous group of cancers with several distinct histotypes and grades. NF-\#312;B can function as an oncogene or tumor suppressor depending on cancer types. The role of NF-\#954;B in low-grade serous ovarian cancer, however, has never been tested. We sought to elucidate the function of NF-\#954;B in an ovarian cancer cell line, HOC-7, which is derived from a well-differentiated (low-grade) papillary serous carcinoma. DNA sequencing analysis revealed a KRAS mutation in this cell line. Introduction of a dominant negative mutant, I\#312;B\#945;M resulted in cell proliferation and inhibition of apoptosis. Western blot analysis indicated increased expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL, reduced expression of the pro-apoptotic proteins Bax, Bad, and Bid. An in vivo animal assay performed on BALB/athymic nude mice showed that injection of HOC-7 induced subcutaneous tumor growth, but the tumor was completely regressed within 2 weeks. HOC-7/I\#312;B\#945;M cells caused sustained tumor growth and delayed regression, compared with control cells. These data suggested that knock-down of NF-\#312;B by I\#312;B\#945;M promoted sustained tumor growth and delayed tumor regression in HOC-7 cells. Our results demonstrated that NF-\#954;B may function as a tumor suppressor by facilitating regression of low grade ovarian serous carcinoma through pro-apoptotic pathway.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-122.
LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML
Authors: Monica Cusan, Sheng F. Cai, Helai P. Mohammad, Andrei Krivtsov, Alan Chramiec, Evangelia Loizou, Matthew D. Witkin, Kimberly N. Smitheman, Daniel G. Tenen, Min Ye, Britta Will, Ulrich Steidl, Ryan G. Kruger, Ross L. Levine, Hugh Y. Rienhoff, Richard P. Koche, Scott A. Armstrong
Journal: Blood (2018)
Coordinated Epithelial and Eosinophil Inflammatory Pathways Underpin Upper Respiratory Tract Viral Infection (URI) Triggered Asthma Exacerbations
Authors: Matthew C. Altman, Denise Babineau, Elizabeth Whalen, Michelle A. Gill, Baomei Shao, Andrew H. Liu, Brett Jepson, Rebecca S. Gruchalla, George T. O'Connor, Jacqueline A. Pongracic, Carolyn M. Kercsmar, Gurjit K. Khurana Hershey, Edward M. Zoratti, Christine Cole Johnson, Stephen J. Teach, Meyer Kattan, Leonard B. Bacharier, Avraham Beigelman, Steve M. Sigelman, Peter J. Gergen, Lisa M. Wheatley, Scott Presnell, Alkis Togias, William W. Busse, Daniel J. Jackson
Journal: Journal of Allergy and Clinical Immunology (2018)
Cholédocoduodénostomie échoendoscopiquement guidée avec les prothèses d'apposition Hot Axios. Résultats de l'ensemble des procédures françaises depuis la commercialisation
Authors: B Napoléon, J Privat, F Pinard, F Fumex, J Jacques, JC Valats, A Chaoui, U Chaput, F Cholet, B Godart, P Grandval, R Legros
Journal: Endoscopy (2018)

La cholédocoduodénostomie sous échoendoscopie (CDE) est une alternative au drainage radiologique percutané en cas de tumeur duodénopancréatique obstruant la voie biliaire (VBP) avec échec de cathétérisme biliaire (CPRE). Le geste est techniquement difficile avec un taux de succès de 94% pour un taux de complication de 19% (1). Un nouveau modèle de prothèse d'apposition entièrement couverte couplée à un cystotome (Hot Axios Boston Scientific) simplifie et sécurise la procédure. Les résultats de la première étude rétrospective internationale sont prometteurs (2). Le but de notre étude est d'évaluer rétrospectivement les résultats de l'ensemble des procédures effectuées en France depuis la commercialisation du produit en avril 2016.
Résection par dissection sous-muqueuse des carcinomes épidermoïdes de l'oesophage: évaluation des résultats à long terme
Authors: D Lorenzo, M Barret, S Leblanc, B Terris, F Beuvon, R Coriat, S Chaussade, F Prat
Journal: Endoscopy (2018)

La dissection sous muqueuse endoscopique est devenue le standard de la prise en charge des carcinomes épidermoïdes superficiels de l'oesophage, en tant que procédure de stadification comme en tant que traitement potentiellement curatif. Cependant, les données issues de centres occidentaux sont rares.
Invasive aspergillosis with pulmonary and central nervous system involvement during ibrutinib therapy for relapsed chronic lymphocytic leukaemia: case report
Authors: A.M. Peri, L. Bisi, A. Cappelletti, E. Colella, L. Verga, C. Borella, S. Foresti, G.M. Migliorino, A. Gori, A. Bandera
Journal: Clinical Microbiology and Infection (2018)
Abstract 12284: Hospital Patient Satisfaction Scores and 30-day Readmission and Mortality Rates of Heart Failure Patients
Authors: Mohamed G Hussein, Rehan Qayyum
Journal: Circulation (2015)

Introduction: Heart failure (HF) is associated with significant mortality and hospital readmissions. High quality health care is associated with improved outcomes in HF patients. A widely used metric to assess the quality of health care provided by hospitals is patient satisfaction. However, the relationship between a hospital’s patient satisfaction scores and that hospital’s mortality rate and readmissions for HF patients is unclear. Methods: We used most recent publicly available data from the Hospital Compare website to examine the relationship between patient satisfaction and 30-day unplanned readmissions and mortality for HF patients. Readmission and mortality rates are reported after adjusting for clinical risk factors. We used multivariable linear regression to explore the relationship between patient satisfaction and HF readmissions and mortality adjusting for hospital and local characteristics (hospital ownership, provision of emergency services, teaching hospital status, survey response rate, percentage insured and poverty). Results: Of the 3595 hospitals, 965(27%) were teaching hospitals. Mean (SD) survey response rate was 31.6%(7.3), satisfaction 69.8%(8.7), readmission rate 22.7(1.6) and mortality rate 12.0(1.5). In unadjusted regression, lower 30-day readmission rate but higher mortality rate were associated with high patient satisfaction (-1.4%/unit increase in readmission rate, p&lt;0.001 and 0.2%/unit increase in mortality rate, p=0.03). After adjusting for potential confounders, the readmission rate remained a strong negative predictor of patient satisfaction (-0.75%, P&lt;0.001), however, there was no significant association with mortality (-0.09%, P=0.26). Conclusions: We found that 30-day readmission rate, but not mortality rate, in HF patients is a strong negative predictor of patient satisfaction with hospitals. Strategies aimed at reducing HF readmissions may increase patient satisfaction with hospitals.
Traitement de l'empierrement et des gros calculs cholédociens au sein d'un service marocain: Taux de succès, complications et facteurs associés
Authors: S Jamal, H Seddik, S Berrag, K Loubaris, F Bouhamou, S Morabit, H Boutallaka, A Aomari, R Berraida, I El Koti, A Benkirane
Journal: Endoscopy (2018)

La sphinctérotomie biliaire endoscopique est efficace dans le traitement de la lithiase de la voie biliaire principale permettant d'obtenir une vacuité complète de celle-ci dans 85 à 90% des cas. Toutefois ces résultats peuvent être limités par la présence de gros calculs ou d'un empirement cholédocien.