tbuckley/cabot-search huggingface dataset:
ECDC <i>Vibrio</i> Map Viewer: Tracking the Whereabouts of Pathogenic Species
Authors: Sharon Levy
Journal: Environmental Health Perspectives (2018)

Vibrio bacteria are found in marine and estuarine waters around the globe. 1 Several Vibrio species cause disease in humans. 1 The bacteria thrive in low-salinity waters, and growth booms when sea surface temperature (SST) exceeds 18 C (64 F). 2 A team at the European Centre for Disease Prevention and Control (ECDC) has developed a tool, the ECDC Vibrio Map Viewer, that uses real-time remotely sensed data on SST and sea surface salinity to predict the occurrence of environmental conditions that favor Vibrio proliferation.In a new study in Environmental Health Perspectives, the researchers demonstrate that the ECDC Vibrio Map Viewer accurately predicted habitat conditions in the coastal Baltic Sea that led to an outbreak of Vibrio infections in Sweden in the summer of 2014. 3 The most infamous member of the Vibrio family is toxigenic V. cholerae, the cause of pandemic cholera; infections with other pathogenic vibrios are relatively rare but can be life-threatening.The number of such Vibrio infections has risen in tandem with increasing SSTs in temperate and cold regions, including coastal Chile, Peru, the Baltic and North Seas, and the North Atlantic. 4,5ibrio-caused illnesses (known collectively as vibriosis) include gastroenteritis, wound infections, and septicemia. 6Patients who are immunocompromised or who have underlying conditions such as diabetes, HIV, or liver disease are more likely to suffer potentially fatal systemic infections. 6n July and August of 2014, SSTs on the Baltic coast of Sweden reached unprecedented highs, and the ECDC Vibrio Map Viewer
Loss to Follow-Up in Patients with Proliferative Diabetic Retinopathy after Panretinal Photocoagulation or Intravitreal Anti-VEGF Injections
Authors: Anthony Obeid, Xinxiao Gao, Ferhina S. Ali, Katherine E. Talcott, Christopher M. Aderman, Leslie Hyman, Allen C. Ho, Jason Hsu
Journal: Ophthalmology (2018)
Transplantation of Fetal Substantia Nigra and Adrenal Medulla to the Caudate Nucleus in Two Patients with Parkinson's Disease
Authors: I Madrazo, V León, C Torres, M C Aguilera, G Varela, F Alvarez, A Fraga, R Drucker-Colín, F Ostrosky, M Skurovich
Journal: New England Journal of Medicine (1988)
Questions About a Clinical Trial Evaluating the Addition of Cetuximab to Definitive Chemoradiation Therapy With Paclitaxel and Cisplatin for Patients With Esophageal Cancer
Authors: Jing Liu, Jinbo Yue
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Role of the HGF/c-MET tyrosine kinase inhibitors in metastasic melanoma
Authors: Lucia Demkova, Lucia Kucerova
Journal: Molecular Cancer (2018)

Metastatic disease in a cancer patient still remains a therapeutic challenge. Metastatic process involves many steps, during which malignant cells succeed to activate cellular pathways promoting survival in hostile environment, engraftment and growth at the distant site from the primary tumor. Melanoma is known for its high propensity to produce metastases even at the early stages of the disease. Here we summarize the most important molecular mechanisms which were associated with the melanoma metastasis. Then, we specifically focus on the signaling pathway mediated by hepatocyte growth factor (HGF) and its receptor c-Met, which play an important role during physiological processes and were been associated with tumorigenesis. We also focus on the effect of the small molecule inhibitors of the tyrosine kinase domain of the c-Met receptor and its effects on properties of melanoma cell. We summarize recent studies, which involved inhibition of the HGF/c-Met signaling in order to decrease melanoma growth and metastatic capacity.
REGISTERED NURSE-ADMINISTERED SEDATION WITH PROPOFOL IN PATIENTS UNDERGOING ENDOSCOPIC ULTRASONOGRAPHY (USE): PROSPECTIVE ANALYSIS
Authors: C Huertas, M Figa, M Hombrados, H Uchima, D Busquets, M Albert, C Luz Rosales, L Peries, L Gutiérrez, X Aldeguer
Journal: Endoscopy (2018)

To analyze the safety profile of supervised nurse-administered sedation with propofol in monotherapy in a cohort of patients undergoing USE in a hospital tertiary.
Exercise Remodels Heart in Middle Age
Authors: Anita Slomski
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic management of eosinophilic esophagitis presenting as a double lumen esophagus
Authors: Jose Santiago Garcia, John Duffy, Jacobo Ortiz-Fernandez-Sordo, Shivkumar Budihal, Adolfo Parra-Blanco, Krish Ragunath
Journal: Endoscopy (2020)

A 19-year-old man was referred to our unit with a 5-year history of dysphagia and food impaction. Upper endoscopy revealed a concentric stricture in the proximal esophagus, which underwent subsequent balloon dilation to 15 mm. Strikingly, a well-established mucosal septum was identified below the stricture, forming a double-lumen esophagus (DLE) that partially obstructed the esophagus ([Fig. 1]). Biopsies from the mid and distal esophagus revealed inflammation, and high dose proton pump inhibitors were started.
Regenerative Medicine: Hierarchical Design of Tissue Regenerative Constructs (Adv. Healthcare Mater. 6/2018)
Authors: Jonas C. Rose, Laura De Laporte
Journal: Advanced Healthcare Materials (2018)

In article number 1701067, Laura De Laporte and Jonas C. Rose review the strategy of hierarchical design of regenerative materials, which closely mimics nature. Thereby, as shown in the image, biochemical (blue), mechanical (grey), and structural (green) cues on different length scales (roots) are combined into macroscopic constructs via advanced fabrication techniques. The biomaterials are dynamic as they respond to the interactions with cells over time (seasons) in order to form functional tissue.
PREDICTIVE FACTORS OF FALSE-POSITIVE FECAL IMMUNOCHEMICAL TEST RESULTS
Authors: C Mangas, E Santana, J Cubiella, A Suárez, I Portillo, A Seoane, M Ponce, P Díez, E Quintero, M Herráiz, M Pellisé, Á Ferrández, V Hernández, Á Pizarro, R Jover
Journal: Endoscopy (2018)

Colorectal cancer (CRC) screening aims the reduction of the incidence and mortality of CRC, and fecal immunochemical test (FIT) is one of the main screenings methods. Since it was introduced, the number of colonoscopies has increased, so the burden of procedures as well. False-positive FIT results (FP-FIT) increase the unnecessary procedures and there is scarce evidence about the FP-FIT rate in Spain. So the aim of this study was to evaluate the FP-FIT rate and the factors related to it.
Hair Loss Associated With Cucurbit Poisoning
Authors: Philippe Assouly
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Sixty seconds on . . . prostate cancer
Authors: Nigel Hawkes
Journal: BMJ (2018)

As reluctant as surgeons are to do nothing, an important trial published last year put a crimp in their confidence. PIVOT followed 731 men with early prostate cancer who were randomised to prostatectomy or observation and followed up for almost 20 years. It found that surgery didn’t lead to lower mortality from all causes or from prostate cancer.1

That’s …
Drilling and Production Activity Related to Unconventional Gas Development and Severity of Preterm Birth
Authors: Kristina Walker Whitworth, Amanda Kaye Marshall, Elaine Symanski
Journal: Environmental Health Perspectives (2018)

Background: Studies of unconventional gas development (UGD) and preterm birth (PTB) have not presented risk estimates by well development phase or trimester. Objective: We examined phase and trimester-specific associations between UGD activity and PTB. Methods: We conducted a case–control study of women with singleton births in the Barnett Shale area, Texas, from 30 November 2010 to 29 November 2012. We individually age- and race/ethnicity-matched five controls to each PTB case (n=13,328) and truncated controls' time at risk according to the matched case's gestational age. We created phase-specific UGD-activity metrics: a) inverse squared distance–weighted (IDW) count of wells in the drilling phase ≤0.5 mi (804.7 meters) of the residence and b) IDW sum of natural gas produced ≤0.5 mi of the residence. We also constructed trimester- and gestation-specific metrics. Metrics were categorized as follows: zero wells (reference), first, second, third tertiles of UGD activity. Analyses were repeated by PTB severity: extreme, very, and moderate (<28, 28 to<32, and 32 to<37 completed weeks). Data were analyzed using conditional logistic regression. Results: We found increased odds of PTB in the third tertile of the UGD drilling {odds ratio (OR)=1.20 [95% confidence interval (CI): 1.06, 1.37]} and UGD-production [OR=1.15 (1.05, 1.26)] metrics. Among women in the third tertile of UGD-production, associations were strongest in trimesters one [OR=1.18 (1.02, 1.37)] and two [OR=1.14 (0.99, 1.31). The greatest risk was observed for extremely PTB [third tertile ORs: UGD drilling, 2.00 (1.23, 3.24); UGD production, 1.53 (1.03–2.27)]. Conclusions: We found evidence of differences in phase- and trimester-specific associations of UGD and PTB and indication of particular risk associated with extremely preterm birth. Future studies should focus on quantifying specific chemical and nonchemical stressors associated with UGD. https://doi.org/10.1289/EHP2622
Abstract 19854: Whole Genome Sequences and Plasma Lipids in 2,255 Participants
Authors: Pradeep Natarajan, Seyedeh M Sekavat, Andrea Ganna, Andres Metspalu, Benjamin Neale, Tonu Esko, Sekar Kathiresan
Journal: Circulation (2016)

Introduction:  Plasma lipids are heritable risk factors for coronary heart disease. High-coverage whole genome sequences allow enumeration of DNA sequence variants of all types (point mutations, structural variants) in different genomic locations (coding, non-coding), and across full range of frequencies (common, rare).   Hypothesis:  Common and rare DNA sequence variants in coding and non-coding sequence associate with plasma lipids.   Methods:  We performed whole genome sequencing to 30X in 2,255 participants from the Estonian Biobank. We tested the association of plasma lipids with DNA sequence variants using three models: 1) common variant association analysis; 2) rare variant association analysis in coding sequence (allele frequency    Results:  Across 2,255 participants, whole genomes sequencing identified 32.4 million DNA sequence variants (29.8 million single nucleotide polymorphisms, 2.6 million insertions-deletions). Common variant analyses replicated established associations at APOE with LDL cholesterol, CETP with HDL cholesterol, LPA with lipoprotein(a) cholesterol, and APOA5 and LPL with triglycerides. Rare variant analysis in coding sequence replicated associations at Mendelian genes, such as LDLR and APOB for LDL cholesterol. Using chromHMM annotations from ENCODE and Roadmap in a hepatocyte cell line, we identified rare variants at enhancers within 20 kilobases of the transcription start site of the 301 genes. When grouping non-coding variants by gene, the following genes demonstrated associations with nominal p-value    Conclusions:  Whole genome sequences allow for the analysis and discovery of rare, regulatory variants associated with plasma lipids.
Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti–Tumor Necrosis Factor Therapy in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis With Clinically Inactive Disease
Authors: Daniel J. Lovell, Anne L. Johnson, Bin Huang, Beth S. Gottlieb, Paula W. Morris, Yukiko Kimura, Karen Onel, Suzanne C. Li, Alexei A. Grom, Janalee Taylor, Hermine I. Brunner, Jennifer L. Huggins, James J. Nocton, Kathleen A. Haines, Barbara S. Edelheit, Michael Shishov, Lawrence K. Jung, Calvin B. Williams, Melissa S. Tesher, Denise M. Costanzo, Lawrence S. Zemel, Jason A. Dare, Murray H. Passo, Kaleo C. Ede, Judyann C. Olson, Elaine A. Cassidy, Thomas A. Griffin, Linda Wagner‐Weiner, Jennifer E. Weiss, Larry B. Vogler, Kelly A. Rouster‐Stevens, Timothy Beukelman, Randy Q. Cron, Daniel Kietz, Kenneth Schikler, Kara M. Schmidt, Jay Mehta, Dawn M. Wahezi, Tracy V. Ting, James W. Verbsky, B. Anne Eberhard, Steven Spalding, Chen Chen, Edward H. Giannini
Journal: Arthritis & Rheumatology (2018)

Objective To determine the frequency, time to flare, and predictors of disease flare upon withdrawal of anti–tumor necrosis factor (anti‐ TNF ) therapy in children with polyarticular forms of juvenile idiopathic arthritis ( JIA ) who demonstrated ≥6 months of continuous clinically inactive disease. Methods In 16 centers 137 patients with clinically inactive JIA who were receiving anti‐ TNF therapy (42% of whom were also receiving methotrexate [ MTX ]) were prospectively followed up. If the disease remained clinically inactive for the initial 6 months of the study, anti‐ TNF was stopped and patients were assessed for flare at 1, 2, 3, 4, 6, and 8 months. Life‐table analysis, t ‐tests, chi‐square test, and Cox regression analysis were used to identify independent variables that could significantly predict flare by 8 months or time to flare. Results Of 137 patients, 106 (77%) maintained clinically inactive disease while receiving anti‐ TNF therapy for the initial 6 months and were included in the phase of the study in which anti‐ TNF therapy was stopped. Stopping anti‐ TNF resulted in disease flare in 39 (37%) of 106 patients by 8 months. The mean/median ± SEM time to flare was 212/250 ± 9.77 days. Patients with shorter disease duration at enrollment, older age at onset and diagnosis, shorter disease duration prior to experiencing clinically inactive disease, and shorter time from onset of clinically inactive disease to enrollment were found to have significantly lower hazard ratios for likelihood of flare by 8 months ( P &lt; 0.05). Conclusion Over one‐third of patients with polyarticular JIA with sustained clinically inactive disease will experience a flare by 8 months after discontinuation of anti‐ TNF therapy. Several predictors of lower likelihood of flare were identified.
IS DIFFICULT CANNULATION THE MAIN RISK FACTOR FOR POST-ERCP PANCREATITIS DESPITE OF PROPHILACTIC PANCREATIC STENT? A RETROSPECTIVE SINGLE-CENTER STUDY
Authors: V Sandru, M Ilie, O Plotogea, B Ungureanu, I Moroi, G Balan, G Constantinescu
Journal: Endoscopy (2018)

The aim of this study is to examine other potential patient- and procedure-related risk factors besides difficult cannulation and despite of prophylactic pancreatic stents insertion.
Striking Racial/Ethnic Disparities in Liver Cancer Incidence Rates and Temporal Trends in California, 1988–2012
Authors: Christopher Pham, Tse-Ling Fong, Juanjuan Zhang, Lihua Liu
Journal: JNCI Journal of the National Cancer Institute (2018)

Hepatocellular carcinoma (HCC) is characterized by disparate risk patterns by race/ethnicity. We examined HCC incidence patterns and temporal trends among detailed racial/ethnic populations, including disaggregated Asian-American subgroups.
Moral agency among the ruins
Authors: David Dunning
Journal: Behavioral and Brain Sciences (2018)

Doris suggests thought-provoking directions for rehabilitating moral agency within a self that is unaware and incoherent. These directions suggest more radical proposals. First, moral reasoning may serve many different functions beyond merely expressing a person's values. Second, social collaboration may not focus on moral reasoning as much as it does on the "defeaters" of that agency. Ultimately, moral agency may not reside in the individual but in social communities or within external situations.
PSEUDO-TUMORAL HEPATOBILIARY DISTOMATOSIS DIAGNOSED AFTER ENDOSCOPIC BILIARY SPHINCTEROTOMY (CASE REPORT)
Authors: K Loubaris, H Seddik, S Jamal, A Aomari, S Morabit, H Boutallaka, F Bouhamou, I El Koti, A Benkirane
Journal: Endoscopy (2018)

The aim is to report an observation of hepatobiliary distomatosis in its pseudo-tumoral form treated by endoscopic sphincterotomy.
Etude de l'efficacité du ballon gastrique sur la perte de poids avec une prise en charge pluridisciplinaire
Authors: V Costil
Journal: Endoscopy (2009)

Introduction: Le but principal de cette étude est de montrer l'efficacité du ballon gastrique sur la perte de poids, la baisse de l'indice de masse corporelle (IMC) et de l'excès de poids, à la dépose, puis 6 mois et un an après la dépose. Le but secondaire est la comparaison de l'efficacité de deux types de ballons (ballon BIB et ballon Héliosphère).
Serious infection across biologic-treated patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis
Authors: Andrew I Rutherford, Sujith Subesinghe, Kimme L Hyrich, James B Galloway
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Objectives</h3> To compare the incidence of serious infection (SI) across biologic drugs used to treat rheumatoid arthritis (RA) using data from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA). <h3>Methods</h3> The BSRBR-RA is a prospective observational cohort study. This analysis included patients with RA starting a new biologic. The primary outcome was SI defined as an infectious event requiring admission to hospital, intravenous antibiotics or resulting in death. Event rates were calculated and compared across biologics using Cox proportional hazards with adjustment for potential confounders. Secondary outcomes were the rate of infection by organ class and 30-day mortality following infection. <h3>Results</h3> This analysis included 19 282 patients with 46 771 years of follow-up. The incidence of SI was 5.51 cases per 100 patient years for the entire cohort (95% CI 5.29 to 5.71). Compared with etanercept, tocilizumab had a higher risk of SI (HR 1.22, 95% CI 1.02 to 1.47) and certolizumab pegol a lower risk of SI (HR 0.75, 95% CI 0.58 to 0.97) in the fully adjusted model. The 30-day mortality following SI was 10.4% (95% CI 9.2% to 11.6%). <h3>Conclusions</h3> The rate of SI was lower with certolizumab pegol than etanercept in the primary analysis but the result was no longer significant in several sensitivity analyses performed suggesting residual confounding may account for the observed difference. From these results, it would be wrong to conclude that certolizumab pegol has a lower rate of SI than other biologics; however, the risk does not appear to be significantly higher as has previously been suggested.
Manipulation, oppression, and the deep self
Authors: Manuel R. Vargas
Journal: Behavioral and Brain Sciences (2018)

This essay considers various kinds of manipulation cases (local and global, dispositional and situational), and how Doris's Deep Self-style theory of responsibility fares in light of them. Agents acting with preferences adaptively formed under oppression are an especially interesting challenge for this sort of view, and the article considers what options may be available to Doris and others.