Calcium Intake and Cardiovascular Disease Risk
Authors: Ian R. Reid, Alison Avenell, Andrew Grey, Mark J. Bolland
Journal: Annals of Internal Medicine (2017)

Letters2 May 2017Calcium Intake and Cardiovascular Disease RiskIan R. Reid, MD, Alison Avenell, MD, MBBS, Andrew Grey, MD, and Mark J. Bolland, MBChB, PhDIan R. Reid, MDFrom University of Auckland, Auckland, New Zealand, and University of Aberdeen, Aberdeen, United Kingdom.Search for more papers by this author, Alison Avenell, MD, MBBSFrom University of Auckland, Auckland, New Zealand, and University of Aberdeen, Aberdeen, United Kingdom.Search for more papers by this author, Andrew Grey, MDFrom University of Auckland, Auckland, New Zealand, and University of Aberdeen, Aberdeen, United Kingdom.Search for more papers by this author, and Mark J. Bolland, MBChB, PhDFrom University of Auckland, Auckland, New Zealand, and University of Aberdeen, Aberdeen, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0135 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their review of calcium intake and cardiovascular disease, Chung and colleagues (1) did not perform a meta-analysis of randomized controlled trials (RCTs) as their title suggests. They identified only 2 trials reporting the effects of calcium plus vitamin D on cardiovascular events and 3 trials of calcium alone, whereas we have reported data on myocardial infarction or stroke from 13 studies of calcium with or without vitamin D (4 trials of calcium plus vitamin D and 11 trials of calcium monotherapy, with 2 studies comparing both calcium and calcium plus vitamin D with placebo) (2). For ...References1. Chung M, Tang AM, Fu Z, Wang DD, Newberry SJ. Calcium intake and cardiovascular disease risk: an updated systematic review and meta-analysis. Ann Intern Med. 2016;165:856-66. [PMID: 27776363]. doi:10.7326/M16-1165 LinkGoogle Scholar2. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. 2011;342:d2040. [PMID: 21505219] doi:10.1136/bmj.d2040 CrossrefMedlineGoogle Scholar3. Lewis JR, Radavelli-Bagatini S, Rejnmark L, Chen JS, Simpson JM, Lappe JM, et al. The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: a collaborative meta-analysis of randomized controlled trials. J Bone Miner Res. 2015;30:165-75. [PMID: 25042841] doi:10.1002/jbmr.2311 CrossrefMedlineGoogle Scholar4. Bolland MJ, Leung W, Tai V, Bastin S, Gamble GD, Grey A, et al. Calcium intake and risk of fracture: systematic review. BMJ. 2015;351:h4580. [PMID: 26420387] doi:10.1136/bmj.h4580 CrossrefMedlineGoogle Scholar5. Jørgensen AW, Hilden J, Gøtzsche PC. Cochrane reviews compared with industry supported meta-analyses and other meta-analyses of the same drugs: systematic review. BMJ. 2006;333:782-85. [PMID: 17028106] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Auckland, Auckland, New Zealand, and University of Aberdeen, Aberdeen, United Kingdom.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0135. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCalcium Intake and Cardiovascular Disease Risk Mei Chung , Alice M. Tang , Zhuxuan Fu , Ding Ding Wang , and Sydne Jennifer Newberry Calcium Intake and Cardiovascular Disease Risk Mei Chung , Alice M. Tang , and Sydne Jennifer Newberry Calcium Intake and Cardiovascular Disease Risk Aisawan Petchlorlian Calcium Intake and Cardiovascular Disease Risk Joshua R. Lewis and Richard L. Prince Calcium Intake and Cardiovascular Disease Risk Elizabeth J. Samelson Metrics Cited byNutritional Supplements and Skeletal HealthDrug use is associated with lower plasma magnesium levels in geriatric outpatients; possible clinical relevanceAssociation Among Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults A Cohort StudyFan Chen, MS, MPH, Mengxi Du, MS, MPH, Jeffrey B. Blumberg, PhD, Kenneth Kwan Ho Chui, PhD, MPH, Mengyuan Ruan, MS, Gail Rogers, MA, Zhilei Shan, MD, PhD, Luxian Zeng, MD, MPH, and Fang Fang Zhang, MD, PhDHigh calcium intake in men not women is associated with all-cause mortality risk: Melbourne Collaborative Cohort StudyCalcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytesCalcium and vitamin D in human health: Hype or real?Calcium and Cardiovascular Disease 2 May 2017Volume 166, Issue 9Page: 684-685KeywordsCalciumCardiovascular disease riskDisclosureMyocardial infarctionObservational studiesRandomized trialsRelative riskResearch designRisk managementVitamin D ePublished: 2 May 2017 Issue Published: 2 May 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...