tbuckley/cabot-search huggingface dataset:
Identifying Trends in Undiagnosed Diabetes in U.S. Adults by Using a Confirmatory Definition
Authors: Elizabeth Selvin, Dan Wang, Alexandra K. Lee, Richard M. Bergenstal, Josef Coresh
Journal: Annals of Internal Medicine (2017)

Background: A common belief is that one quarter to one third of all diabetes cases remain undiagnosed. However, such prevalence estimates may be overstated by epidemiologic studies that do not use confirmatory testing, as recommended by clinical diagnostic criteria. Objective: To provide national estimates of undiagnosed diabetes by using a confirmatory testing strategy, in line with clinical practice guidelines. Design: Cross-sectional study. Setting: National Health and Nutrition Examination Survey results from 1988 to 1994 and 1999 to 2014. Participants: U.S. adults aged 20 years and older. Measurements: Confirmed undiagnosed diabetes was defined as elevated levels of fasting glucose (≥7.0 mmol/L [≥126 mg/dL]) and hemoglobin A1c (≥6.5%) in persons without diagnosed diabetes. Results: The prevalence of total (diagnosed plus confirmed undiagnosed) diabetes increased from 5.5% (9.7 million adults) in 1988 to 1994 to 10.8% (25.5 million adults) in 2011 to 2014. Confirmed undiagnosed diabetes increased during the past 2 decades (from 0.89% in 1988 to 1994 to 1.2% in 2011 to 2014) but has decreased over time as a proportion of total diabetes cases. In 1988 to 1994, the percentage of total diabetes cases that were undiagnosed was 16.3%; by 2011 to 2014, this estimate had decreased to 10.9%. Undiagnosed diabetes was more common in overweight or obese adults, older adults, racial/ethnic minorities (including Asian Americans), and persons lacking health insurance or access to health care. Limitation: Cross-sectional design. Conclusion: Establishing the burden of undiagnosed diabetes is critical to monitoring public health efforts related to screening and diagnosis. When a confirmatory definition is used, undiagnosed diabetes is a relatively small fraction of the total diabetes population; most U.S. adults with diabetes (about 90%) have received a diagnosis of the condition. Primary Funding Source: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases and National Heart, Lung, and Blood Institute.
Anticancer Activity and Tolerance of Treatments Received Beyond Progression in Men Treated Upfront with Androgen Deprivation Therapy With or Without Docetaxel for Metastatic Castration-naïve Prostate Cancer in the GETUG-AFU 15 Phase 3 Trial
Authors: Pernelle Lavaud, Gwenaëlle Gravis, Stéphanie Foulon, Florence Joly, Stéphane Oudard, Frank Priou, Igor Latorzeff, Loïc Mourey, Michel Soulié, Remy Delva, Ivan Krakowski, Brigitte Laguerre, Christine Théodore, Jean Marc Ferrero, Philippe Beuzeboc, Muriel Habibian, Frédéric Rolland, Gael Deplanque, Damien Pouessel, Sylvie Zanetta, Jean François Berdah, Jerome Dauba, Marjorie Baciuchka, Christian Platini, Claude Linassier, Nicole Tubiana-Mathieu, Jean Pascal Machiels, Claude El Kouri, Alain Ravaud, Etienne Suc, Jean Christophe Eymard, Ali Hasbini, Guilhem Bousquet, Stéphane Culine, Jean-Marie Boher, Gabrielle Tergemina-Clain, Clémence Legoupil, Karim Fizazi
Journal: European Urology (2017)
New Generation Nanomedicines Constructed from Self-Assembling Small-Molecule Prodrugs Alleviate Cancer Drug Toxicity
Authors: Hangxiang Wang, Zhongjie Lu, Lijiang Wang, Tingting Guo, Jiaping Wu, Jianqin Wan, Liqian Zhou, Hui Li, Zhen Li, Donghai Jiang, Penghong Song, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng
Journal: Cancer Research (2017)

Abstract The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies for dose intensification to improve efficacy must also address tolerability. In addressing this issue, we have investigated a novel combinatorial strategy of reconstructing a drug molecule and using sequential drug-induced nanoassembly to fabricate supramolecular nanomedicines (SNM). Using cabazitaxel as a target agent, we established that individual synthetic prodrugs tethered with polyunsaturated fatty acids were capable of recapitulating self-assembly behavior independent of exogenous excipients. The resulting SNM could be further refined by PEGylation with amphiphilic copolymers suitable for preclinical studies. Among these cabazitaxel derivatives, docosahexaenoic acid–derived compound 1 retained high antiproliferative activity. SNM assembled with compound 1 displayed an unexpected enhancement of tolerability in animals along with effective therapeutic efficacy in a mouse xenograft model of human cancer, compared with free drug administered in its clinical formulation. Overall, our studies showed how attaching flexible lipid chains to a hydrophobic and highly toxic anticancer drug can convert it to a systemic self-deliverable nanotherapy, preserving its pharmacologic efficacy while improving its safety profile. Cancer Res; 77(24); 6963–74. ©2017 AACR.
TCT-247 Re-infarction and mortality after STEMI in octogenarian population
Authors: Dominika Klimczak, Mariusz Tomaniak, Maria Tovar, Marcella De Paolis, Joost Daemen, Jeroen Wilschut, Peter de Jaegere, Felix Zijlstra, Nicolas Van Mieghem, Roberto Diletti
Journal: Journal of the American College of Cardiology (2017)
Gait retraining: out of the lab and onto the streets with the benefit of wearables
Authors: Christopher Napier, Jean-Francois Esculier, Michael A Hunt
Journal: British Journal of Sports Medicine (2017)

Movement retraining can correct faulty movement patterns.1 However, as with any treatment, retraining needs to be activity specific—there are various types of ‘retraining’ and the treatment needs to match the movement fault.2 As experts at analysis and rehabilitation of movement, the concept of gait retraining fits well into a sport physiotherapist’s tool kit. The advent of readily accessible high-speed motion capture technology to assess and provide feedback on running patterns allows practitioners to incorporate gait retraining in their clinics. Furthermore, wearable technology makes it possible to measure many metrics ‘in the field’ that were previously only quantifiable in the lab. The purpose of this editorial is to discuss the potential of wearable technology to monitor and give feedback of gait outside of a lab and clinic setting.

Traditionally, gait retraining using real-time biofeedback has been conducted in specialised lab settings with variable degrees of success depending on the targeted outcomes and the form of feedback.3 Sport physiotherapists have primarily applied it to treat injured runners, for instance, those with patellofemoral pain.1 4 …
TCT-486 Acute Thrombogenicity and Inflammation in Response to a Durable Fluoropolymer Everolimus-Eluting Stent Relative to a Durable BioLinx polymer Zotarolimus-Eluting Stent
Authors: Sho Torii, Frank Kolodgie, Qi Cheng, Eduardo Acampado, Laura Perkins, Syed Hossainy, Stephen Pacetti, Aloke Finn, Renu Virmani
Journal: Journal of the American College of Cardiology (2017)
A Europa frente à resistência antimicrobiana
Authors: M J Struelens
Journal: Eurosurveillance (2004)

Neste numero, Witte e colegas descrevem a emergencia, desde 2002, na Alemanha, de casos de infeccoes adquiridas na comunidade por Staphylococcus aureus resistentes a meticilina (c-MRSA) produtores de leucocidina de Panton-Valentine. Este artigo mostra indicios da rapida disseminacao geografica na Europa desta variante emergente e muito virulenta de um patogene ja conhecido.
TCT-561 Long-term Outcome with Jetstream Atherectomy with or without Drug Coated Balloons in Treating denovo Femoropopliteal Arteries
Authors: Nicolas W. Shammas, Gail Shammas, Sue Jones-Miller, Bassel Bou Dargham, Andrew Shammas, Subhash Banerjee, Rayan Jo Rachwan, Ghassan Daher, W John Shammas
Journal: Journal of the American College of Cardiology (2017)
Chromatin Conformation Links Distal Target Genes to CKD Loci
Authors: Maarten M. Brandt, Claartje A. Meddens, Laura Louzao-Martinez, Noortje A.M. van den Dungen, Nico R. Lansu, Edward E.S. Nieuwenhuis, Dirk J. Duncker, Marianne C. Verhaar, Jaap A. Joles, Michal Mokry, Caroline Cheng
Journal: Journal of the American Society of Nephrology (2017)

Export Genome-wide association studies (GWASs) have identified many genetic risk factors for CKD. However, linking common variants to genes that are causal for CKD etiology remains challenging. By adapting self-transcribing active regulatory region sequencing, we evaluated the effect of genetic variation on DNA regulatory elements (DREs). Variants in linkage with the CKD-associated single-nucleotide polymorphism rs11959928 were shown to affect DRE function, illustrating that genes regulated by DREs colocalizing with CKD-associated variation can be dysregulated and therefore, considered as CKD candidate genes. To identify target genes of these DREs, we used circular chromosome conformation capture (4C) sequencing on glomerular endothelial cells and renal tubular epithelial cells. Our 4C analyses revealed interactions of CKD-associated susceptibility regions with the transcriptional start sites of 304 target genes. Overlap with multiple databases confirmed that many of these target genes are involved in kidney homeostasis. Expression quantitative trait loci analysis revealed that mRNA levels of many target genes are genotype dependent. Pathway analyses showed that target genes were enriched in processes crucial for renal function, identifying dysregulated geranylgeranyl diphosphate biosynthesis as a potential disease mechanism. Overall, our data annotated multiple genes to previously reported CKD-associated single-nucleotide polymorphisms and provided evidence for interaction between these loci and target genes. This pipeline provides a novel technique for hypothesis generation and complements classic GWAS interpretation. Future studies are required to specify the implications of our dataset and further reveal the complex roles that common variants have in complex diseases, such as CKD.
Abstract 19057: Disruption of Endothelial Frizzled 5 Signalling Inhibits Angiogenesis and Induces PKC-Mediated Upregulation of Vascular Regression Associated Genes
Authors: Maarten Brandt, Christian G van Dijk, Ihsan Chrifi, Marianne C Verhaar, Dirk J Duncker, Caroline Cheng
Journal: Circulation (2016)

Introduction: The process of neo vessel formation is tightly regulated and imbalances in signalling can be a causative or a progressive factor in many vascular defect associated diseases. In previo...
An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors
Authors: Yong-Chen Lu, Zhili Zheng, Paul F. Robbins, Eric Tran, Todd D. Prickett, Jared J. Gartner, Yong F. Li, Satyajit Ray, Zulmarie Franco, Valery Bliskovsky, Peter C. Fitzgerald, Steven A. Rosenberg
Journal: Molecular Therapy (2017)

The adoptive transfer of neoantigen-reactive tumor-infiltrating lymphocytes (TILs) can result in tumor regression in patients with metastatic cancer. To improve the efficacy of adoptive T cell therapy targeting these tumor-specific mutations, we have proposed a new therapeutic strategy, which involves the genetic modification of autologous T cells with neoantigen-specific T cell receptors (TCRs) and the transfer of these modified T cells back to cancer patients. However, the current techniques to isolate neoantigen-specific TCRs are labor intensive, time consuming, and technically challenging, not suitable for clinical applications. To facilitate this process, a new approach was developed, which included the co-culture of TILs with tandem minigene (TMG)-transfected or peptide-pulsed autologous antigen-presenting cells (APCs) and the single-cell RNA sequencing (RNA-seq) analysis of T cells to identify paired TCR sequences associated with cells expressing high levels of interferon-γ (IFN-γ) and interleukin-2 (IL-2). Following this new approach, multiple TCRs were identified, synthesized, cloned into a retroviral vector, and then transduced into donor T cells. These transduced T cells were shown to specifically recognize the neoantigens presented by autologous APCs. In conclusion, this approach provides an efficient procedure to isolate neoantigen-specific TCRs for clinical applications, as well as for basic and translational research.
TCT-444 The prognostic significance of complete revascularization across all indications for percutaneous coronary intervention: an analysis of 28,632 patients with multivessel disease from the British Columbia Cardiac Registry
Authors: Peter Moore, Navin Chandra, Imad Nadra, Simon Robinson, None Eric Fretz, Lilian Ding, Sean Hardiman, Anthony Fung, Eve Aymong, Albert Chan, Steven Hodge, David Wood, Anthony Della Siega, Bilal Iqbal
Journal: Journal of the American College of Cardiology (2017)
Abstract 12533: Pulmonary Hypertension due to Left Atrium Stenosis Caused Intrapulmonary Venous Arterialization in Rats
Authors: Yoshitaka Fujimoto, Takashi Urashima, Toru Akaike, Yoichiro Kusakari, Susumu Minamisawa
Journal: Circulation (2016)

Introduction: Pulmonary hypertension (PH) due to left heart diseases (PH-LHD) is known as the most frequent cause of PH. Although pulmonary artery hypertension have been intensively investigated, the pathological mechanism and treatment of PH-LHD still remain unclear because of the lack of an adequate animal model of PH-LHD. Objective: The aim of this study was to investigate the pathophysiological characters of a novel rat model of PH-LHD caused by left atrium stenosis (LAS). Methods: Five-week-old male Sprague-Dawley rats were randomly divided into the two groups: the LAS and sham-operated control (SOC) groups. Through open heart surgery under anesthesia, LAS was generated by clipping the LA using HORIZON TM ligation clip (n=5). Thymectomy was only done in SOC group (n=5). Echocardiography was performed every 2 weeks after operation, and hemodynamic measurements and tissues were collected 10 weeks after operation. Results: Left ventricular (LV) inflow velocity measured by echocardiography was higher in LAS than in SOC group (2.2±0.2 and 1.1±0.03 m/s, p &lt;0.01). Right ventricular (RV) pressure and RV pressure/LV pressure ratio were significantly increased in LAS than in SOC group (40.6±14.4 and 18.0±5.0 mmHg, p &lt;0.01, 0.52±0.10 and 0.22±0.09, p &lt;0.01, respectively). In addition, RV was weighted more in LAS than in SOC group (242±28 and 164±36 mg, p &lt;0.01). Histological examination revealed that not only pulmonary arteriopathy with isolated medial hypertrophy, but also pulmonary venous arterialization in LAS group. Pulmonary venous media was significantly thickened in all of LAS rats when compared with that in SOC group. Furthermore, α-smooth muscle actin, ephrin-B2, and EphB4 (ephrin-B2 cognate receptor) were significantly increased in LAS group by immunohistological and real-time PCR analyses. Conclusions: We succeeded in establishing a novel, reliable rat model of PH-LHD by generating LAS for the first time in the world. Although PH was relatively mild, the PH-LHD model rats demonstrated the characteristic intrapulmonary venous arterialization and should be utilized to further investigate the mechanism of PH-LHD.
Competing interests in journal editors
Authors: Virginia Barbour
Journal: BMJ (2017)

Individuals are almost incapable of determining whether their own conflicts of interest or competing interests might affect their judgment. To mitigate bias in published work (or the perception of bias in that work), journals are increasingly tightening their requirements for authors and reviewers to declare and publish competing interests. The study by Liu and colleagues (doi:10.1136/bmj.j4619)1 opens up a new front in the debate—reporting payments by drug and device companies to US doctors who are also editors of academic journals.
TCT-344 Clinical Outcomes of Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients Stratified by STS Score: Results from the SURTAVI Trial
Authors: Patrick Serruys, Mohammad Abdelghani, Jeffrey J. Popma, Michael J. Reardon, Neal Kleiman, Juan Crestanello, Scott Lillly, Ad Van Boven, Piet Willem Boonstra, Nicolo Piazza, Nicolas Van Mieghem, A. Pieter Kappetein
Journal: Journal of the American College of Cardiology (2017)
TCT-833 Influence of Angina on Outcomes After Revascularization in Patients with Left Main Coronary Artery disease: Insights from the EXCEL Trial
Authors: Serge Doucet, Marc Jolicoeur, A. Pieter Kappetein, Yiran Zhang, Joseph Sabik, Patrick Serruys, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
TCT-627 Electrocardiographic parameters, peak of cardiac markers and diagnosis delay in patients with acute left circumflex occlusion
Authors: Pedro Pérez-Díaz, Alfonso Jurado-Román, Ignacio Sanchez-Perez, María Thiscal López Lluva, Ramón Maseda Uriza, Jesus Piqueras-Flores, Fernando Lozano
Journal: Journal of the American College of Cardiology (2017)
Job change facilitates healing in a cohort of patients with occupational hand eczema
Authors: T.K. Carøe, N.E. Ebbehøj, J.P.E. Bonde, S.G. Vejlstrup, T. Agner
Journal: British Journal of Dermatology (2017)

Occupational hand eczema is a frequent and often chronic disease and knowledge of the consequences of change of profession is sparse. To compare severity of hand eczema and health‐related quality of life (HR‐QoL) in patients who after 5 years were still in the same profession and those who were not. The study is a register‐based cohort study including patients with recognized occupational hand eczema in Denmark in 2010 and 2011. Outcomes were eczema‐related parameters and Dermatology Life Quality Index (DLQI) scores obtained from a follow‐up questionnaire after 5 years. A total of 1496 participants were included in the study. More participants who changed profession or left the labour market reported complete healing of hand eczema at follow‐up, compared with participants still in the same profession [odds ratio (OR) 1·62, 95% confidence interval (CI) 1·06–2·47 and OR 2·85, 95% CI 1·83–4·42, respectively], in addition to increased improvement at follow‐up (OR 1·91, 95% CI 1·44–2·54 and OR 1·51, 95% CI 1·09–2·10, respectively). However, DLQI scores for participants who changed profession or left the labour market had increased at follow‐up [incidence rate ratio (IRR) 1·12 (95% CI 0·98–1·28 and IRR 1·29, 95% CI 1·11–1·51, respectively]. The results from subgroup analyses of patients with irritant or allergic occupational hand eczema did not differ markedly. Change of work procedures was positively associated with improvement (OR 2·31, 95% CI 1·51–3·54), and did not markedly influence DLQI. Change of profession has a beneficial effect on eczema parameters, but a negative effect on HR‐QoL, indicated by increased DLQI scores. Change of work procedures while staying in the same profession positively influenced improvement, with no marked influence on HR‐QoL, and should be considered as an alternative to job change.
Thomas Maurice Little
Authors: Katherine Little
Journal: BMJ (2017)

Thomas Maurice Little (“Maurice”), who has died aged 75, was a dedicated and skilled paediatrician, a committed volunteer for several charities, and a loving husband and father. He was born near Enniskillen, Northern Ireland, during the second world war, to Emily (nee Ross) and John Little, who were dairy farmers. After attending Portora Royal School in Enniskillen, Maurice read medicine at Queen’s University, Belfast. After graduating he left leaving Northern Ireland to work in Liverpool. …
Importación de un caso de rabia canina en Aquitania : investigación y manejo de los contactos a riesgo, Agosto 2004-Marzo 2005
Authors: V Servas, A Mailles, D Neau, C Castor, A Manetti, E Fouquet, J M Ragnaud, H Bourhy, M C Paty, N Melik, J Astoul, F Cliquet, M P Moiton, C François, M Coustillas, J C Minet, P Parriaud, I Capek, L Filleul
Journal: Eurosurveillance (2005)

En Agosto de 2004, se confirmo un diagnostico de rabia en un cachorro canino importado ilegalmente de Marruecos a Burdeos (Francia). Debido al gran numero de personas y animales que posiblemente estuvieron en contacto con este perro, se llevaron a cabo importantes medidas de seguimiento, asi como una alerta internacional para buscar y tratar los contactos a riesgo. 
Ciento ochenta y siete personas recibieron un tratamiento post-exposicion, de los cuales ocho fueron por seroterapia, y se analizaron 57 animales que habian tenido un contacto confirmado con el cachorro. Seis meses despues de la muerte del animal rabioso, ninguna persona tratada presento sintomas de rabia y no fue declarado ningun caso secundario animal. El manejo de esta crisis pone de manifiesto la importancia de un sistema de alerta rapida al nivel europeo. Es esencial la aplicacion estricta del control sanitario de animales introducidos en los paises de la UE, asi como proporcionar la informacion necesaria a los residentes europeos que viajen a zonas de rabia enzootica.
Testicular Tumour Size and Rete Testis Invasion as Prognostic Factors for the Risk of Relapse of Clinical Stage I Seminoma Testis Patients Under Surveillance: a Systematic Review by the Testicular Cancer Guidelines Panel
Authors: Joost L. Boormans, Javier Mayor de Castro, Lorenzo Marconi, Yuhong Yuan, M. Pilar Laguna Pes, Carsten Bokemeyer, Nicola Nicolai, Ferran Algaba, Jan Oldenburg, Peter Albers
Journal: European Urology (2017)
TCT-590 Results and Outcome Predictors of Impella-protected PCI in High Risk Patients: A Two-centre Experience
Authors: Francesco Burzotta, Giulio Russo, Flavio Ribichini, Anna Piccoli, Domenico D'Amario, Lazzaro Paraggio, Leonardo Previ, Gabriele Pesarini, Italo Porto, Antonio Maria Leone, Giampaolo Niccoli, Cristina Aurigemma, Diana Verdirosi, Carlo Trani, Filippo Crea
Journal: Journal of the American College of Cardiology (2017)
Successful treatment of SAPHO syndrome with apremilast
Authors: S. Adamo, J. Nilsson, A. Krebs, U. Steiner, A. Cozzio, L.E. French, A.G.A. Kolios
Journal: British Journal of Dermatology (2017)

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a rare disease with inflammatory osteoarticular and skin involvement. The pathogenesis of SAPHO syndrome remains unclear, but evidence suggests it may be an autoinflammatory disease triggered upon exposure to infectious agents in genetically predisposed individuals. Induction of the interleukin (IL)‐23/T helper 17 axis in addition to neutrophil activation seem to play a key role, and therapies targeting these immunological pathways, including tumour necrosis factor (TNF) inhibitors, ustekinumab, secukinumab and the IL‐1 inhibitor anakinra, are potential treatment options that need further investigation. Here we report a case of a 24‐year‐old woman with SAPHO syndrome who presented at our clinic with palmoplantar pustulosis and sternoclavicular joint involvement. Previous treatments with topical steroids and keratolytics combined with nonsteroidal anti‐inflammatory drugs, intravenous methylprednisolone, methotrexate and sulfasalazine had all failed to improve symptoms. Therapy with etanercept was not tolerated, and because of a previous demyelinating peripheral neuropathy, further treatment with TNF inhibitors was avoided. We initiated ustekinumab 45 mg, which improved skin manifestations but not joint pain. Dose escalation to 90 mg initially improved joint pain, but the dose had to be reduced to 45 mg again because of increased infections. During subsequent 45‐mg ustekinumab treatment, joint pain exacerbated so we switched to adalimumab which caused an exacerbation of the disease, so we switched to secukinumab, which improved skin and joint symptoms significantly but was associated with a pustular hypersensitivity reaction. Finally, we began treatment with apremilast, a pan‐cytokine approach, resulting in stabilization of the skin and joint symptoms without side‐effects. To our knowledge, this is the first case report of apremilast as a treatment for SAPHO syndrome.
ACC/AATS/AHA/ASE/EACTS/HVS/SCA/SCAI/SCCT/SCMR/STS 2017 Appropriate Use Criteria for the Treatment of Patients With Severe Aortic Stenosis
Authors: Robert O. Bonow, Alan S. Brown, Linda D. Gillam, Samir R. Kapadia, Clifford J. Kavinsky, Brian R. Lindman, Michael J. Mack, Vinod H. Thourani
Journal: Journal of the American College of Cardiology (2017)