tbuckley/cabot-search huggingface dataset:
Effects of Sarcophine-diol on cell proliferation and apoptosis in human epidermoid carcinoma A431 cells
Authors: Xiaoying Zhang, Dustin Schrader, Ajay Bommareddy, Radhey Kaushik, Hesham Fahmy, Chandradhar Dwivedi
Journal: Cancer Research (2007)

4976   Sarcophine-diol (SD), one of the structural modifications of sarcophine, has shown chemopreventive effects on skin tumor developments in mice in our laboratory. Tumorigenesis is associated with cell uncontrolled growth and loss of apoptotic death of cells. The objective of this study was to determine effects of SD on cell proliferation and apoptosis in human epidermoid carcinoma A431 cells to elucidate possible mechanism of action.  BrdU incorporation assay was used for cell proliferation, fluorescence-activated cell sorting (FACS) analysis of Annexin V/propidium iodide (PI) stained cells was used for apoptosis and Western blot was used for determining caspase 3 level. The results showed that SD treatment at concentration of 100μM-400μM resulted in concentration- and a time-dependent decrease in cell proliferation in human epidermoid carcinoma A431 cells. SD treatment at concentration of 50μM-400μM induced a strong apoptosis in human epidermoid carcinoma A431 cells. SD treatment at 400μM can significantly (p   These results suggest that SD could be effective as chemopreventive agent for skin cancer by decreasing cell proliferation and inducing apoptosis though caspase dependent pathway. (Supported by Juhnke Funds from the SDSU Foundation and ASPET Individual Summer Fellowship and Joseph Nelson Undergraduate Mentorship.)
Recurrent Dysarthria and Ataxia in a Young Girl
Authors: Meghan Romba, Ernesto González-Giraldo, Michael Levy
Journal: JAMA Neurology (2017)

A girl with an unremarkable medical history presented with 1 week of drowsiness, double vision, and left cranial nerve VI and VII palsies and later presented with 2 weeks of dysarthria and progressive ataxia without change in mental status. What is your diagnosis?
Epidémie de trichophyties cutanées, une infection fongique due à Trichophyton tonsurans, dans une équipe française de judo de haut niveau
Authors: D. M. Poisson, Didier Rousseau, D Defo, E Estève
Journal: Eurosurveillance (2005)

Une epidemie de 49 cas de trichophyties cutanees, dues a Trichophyton tonsurans, est survenue entre octobre 2004 et avril 2005 dans une equipe de judo de haut niveau de 131 membres a Orleans, au centre de la France. L’equipe etait divisee en cinq groupes : le pole masculin cadet/junior (n=44), le pole feminin cadet/junior (n=33), le pole universitaire masculin (n=15), le pole universitaire feminin (n=21), et un groupe appele « pole technique », compose de judokas de haut niveau ayant termine leurs etudes (n=18). L’epidemie a concerne 86% du pole masculin cadet/junior, mais seulement six hommes du pole technique (33%) et cinq (7%) parmi les 69 autres membres de l’equipe (pole feminin cadet/junior et poles universitaires). L’article decrit cette epidemie et les resultats de l’investigation qui conduit a l’identification d’un facteur de risque connu pour le « pole technique » : le fait de partager une tondeuse a cheveux. Les garcons du pole masculin cadet/junior avaient une hygiene personnelle superieure a celle des autres groupes. Le taux d’attaque eleve au sein de ce groupe etait peut-etre associe a la vetuste des installations de douches dans le gymnase ou ils s’entrainaient qui les a conduits a ne prendre leur douche que plusieurs heures apres la fin de leur pratique quotidienne.
Connective tissue injury in calf muscle tears and return to play: MRI correlation
Authors: Ashutosh Prakash, Tom Entwisle, Michal Schneider, Peter Brukner, David Connell
Journal: British Journal of Sports Medicine (2017)

The aim of our study was to assess a group of patients with calf muscle tears and evaluate the integrity of the connective tissue boundaries and interfaces. Further, we propose a novel MRI grading system based on integrity of the connective tissue and assess any correlation between the grading score and time to return to play. We have also reviewed the anatomy of the calf muscles.We retrospectively evaluated 100 consecutive patients with clinical suspicion and MRI confirmation of calf muscle injury. We evaluated each calf muscle tear with MRI for the particular muscle injured, location of injury within the muscle and integrity of the connective tissue structure at the interface. The muscle tears were graded 0-3 depending on the degree of muscle and connective tissue injury. The time to return to play for each patient and each injury was found from the injury records and respective sports doctors.In 100 patients, 114 injuries were detected. Connective tissue involvement was observed in 63 out of 100 patients and failure (grade 3 injury) in 18. Mean time to return to play with grade 0 injuries was 8 days, grade 1 tears was 17 days, grade 2 tears was 25 days and grade 3 tears was 48 days (p<0.001).The integrity of the connective tissue can be used to estimate and guide the time to return to play in calf muscle tears.
Politiques de vaccination contre le virus de l’herpès zoster et stratégies de surveillance en Europe
Authors: A Pinot de Moira, A Nardone
Journal: Eurosurveillance (2005)

En Europe l’incorporation de la vaccination contre le virus de l’herpes zoster (VHZ) dans le calendrier vaccinal des enfants est une option de plus en plus frequente. L’etude suivante fait partie de l’analyse concernant le VHZ menee dans le cadre du Reseau europeen de surveillance serologique 2 (ESEN2).Y sont decrites les politiques de vaccination passive actuelles, ainsi que les strategies d’immunisation active en cours et a l’etude, et les systemes de surveillance des maladies dues au virus de l’herpes zoster dans les pays participant au reseau ESEN. 
Un questionnaire a ete elabore et envoye aux 23 pays participants. Actuellement, un vaccin contre le VHZ est commercialise dans 14 des 20 pays participant a ESEN. L’Allemagne est le seul pays a avoir inclu le vaccin anti VHZ dans son programme de vaccination pediatrique en routine. Trois autres pays recommandent la vaccination contre le VHZ chez les enfants, et cinq pays ont le projet d’inclure ce vaccin en routine pour les enfants. Cependant, sur les huit pays ayant introduit cette vaccination pour les enfants, ou en instance de le faire, seuls six ont une declaration obligatoire de la varicelle basee sur les cas, et seuls deux pays ont des donnees de surveillance de soins primaires pour l’herpes zoster.
Increased risk of death for men given blood transfusions from previously pregnant women, study shows
Authors: Jacqui Wise
Journal: BMJ (2017)

Men given blood transfusions from women who have previously been pregnant have an increased mortality risk compared with men who receive a transfusion from a male donor or from a woman without a history of pregnancy, an analysis published in JAMA has shown.1

The researchers speculate that the association may be because of immunological changes that occur during pregnancy or a difference in iron status between women who have ever been pregnant and male donors. But they said that further studies are needed to replicate their findings, determine their …
A completely biological “off-the-shelf” arteriovenous graft that recellularizes in baboons
Authors: Zeeshan H. Syedain, Melanie L. Graham, Ty B. Dunn, Timothy O’Brien, Sandra L. Johnson, Robert J. Schumacher, Robert T. Tranquillo
Journal: Science Translational Medicine (2017)

Prosthetic arteriovenous grafts (AVGs) conventionally used for hemodialysis are associated with inferior primary patency rates and increased risk of infection compared with autogenous vein grafts. We tissue-engineered an AVG grown from neonatal human dermal fibroblasts entrapped in bovine fibrin gel that is then decellularized. This graft is both "off-the-shelf" (nonliving) and completely biological. Grafts that are 6 mm in diameter and about 15 cm in length were evaluated in a baboon model of hemodialysis access in an axillary-cephalic or axillary-brachial upper arm AVG construction procedure. Daily antiplatelet therapy was given. Grafts underwent both ultrasound assessment and cannulation at 1, 2, 3, and 6 months and were then explanted for analysis. Excluding grafts with cephalic vein outflow that rapidly clotted during development of the model, 3- and 6-month primary patency rates were 83% (5 of 6) and 60% (3 of 5), respectively. At explant, patent grafts were found to be extensively recellularized (including smoothelin-positive smooth muscle cells with a developing endothelium on the luminal surface). We observed no calcifications, loss of burst strength, or outflow stenosis, which are common failure modes of other graft materials. There was no overt immune response. We thus demonstrate the efficacy of an off-the-shelf AVG that is both acellular and completely biological.
Brote de gastroenteritis por Salmonella bongori 48:z35:- en Sicilia
Authors: A Nastasi, C Mammina, L Salsa
Journal: Eurosurveillance (1999)

La Salmonella bongori 48:z35:- se aislo por primera vez en 1966 en una lagartija de Chad y se clasifico como una cepa bioquimicamente atipica del subgenero I de Kauffmann (1). Posteriormente, se identificaron otras cepas con distintas formulas antigenicas, pero con propiedades bioquimicas similares, y se asignaron al ‘grupo bongor’ del genero salmonella (2). Ultimamente, por sus caracteristicas geneticas y bioquimicas, se ha definido a la S. bongori como una especie de salmonella distinta (3).
Abstract 132: A Novel Hydrogen Sulfide (H <sub>2</sub> S) Prodrug, SG1002, Protects Against Myocardial Oxidative Damage and Hypertrophic Signaling via Induction of Cystathionine &amp;#914;-Synthase (CBS) and Antioxidant Proteins
Authors: Kazi N Islam, Erminia Donnarumma, Erinn Donnelly, David J Lefer
Journal: Circulation Research (2016)

Background: Endogenously produced H 2 S is critical for cardiovascular homeostasis. Therapeutic strategies aimed at increasing H 2 S levels have proven cardioprotective in models of acute myocardial infarction and heart failure (HF). The present study was under taken to investigate the effects of a novel H 2 S prodrug, SG1002, on stress induced hypertrophic signaling in murine HL1 cardiomyocytes. Methods: HL1 cells were maintained either in serum starvation (1%) or serum containing (10%) media followed by treatment either with SG1002 or H 2 O 2 , or endothelin-1 (ET-1)/phenylephrine (Phe) or in combination. Treated cells were analyzed for specific experimental needs. Results: SG1002 significantly increased cellular levels of the H 2 S producing enzyme, CBS, as well as production of H 2 S and nitrosothiol in HL1 cells cultured both in serum starvation or serum containing media. SG1002 significantly inhibited H 2 O 2 and ET-1/Phe induced oxidative stress in both culture media as measured by advanced protein oxidation products and MDA levels. Expression of ANP and BNP were markedly attenuated by SG1002 treatment. Cells cultured in media supplemented with serum containing H 2 O 2 /(ET-1 or Phe) or in 1% serum exhibited decreased levels of CBS, SOD1, and catalase. When the HL1 cells were coincubated with SG1002 cellular damage from oxidative stress was significantly attenuated accompanied by an increase in CBS expression. Conclusion: Our data clearly demonstrate that SG1002 attenuates myocardial cellular damage via increasing antioxidant proteins. SG1002 directly increases H 2 S levels and upregulates CBS. Studies are currently underway to evaluate the clinical utility of SG1002 in HF.
Abstract 12493: Comparison of Prehospital Stroke Scales
Authors: Denisse Sequeira, Christian Martin-Gill, Francis X Guyette, Ashutosh P Jadhav
Journal: Circulation (2015)

Introduction: Stroke is a major cause of death and disability. The availability of time dependent therapies for stroke makes accurate triage critical. Recent data demonstrates superior outcomes in large vessel occlusion (LVO) after the adjunctive use of endovascular therapy. A sufficiently accurate pre-hospital scale is needed to appropriate LVO patients to the closest endovascular-capable center. Various prehospital stroke scales have been described in an attempt to help identify strokes. The objective of this study was to compare the sensitivity and specificity of the four most commonly used stroke scales, CPSS, LAPSS, LAMS and RACE in terms of their accuracy in identifying strokes and stroke severity. The National Institute of Health Stroke Scale serves as the gold standard for comparison. Methods: Retrospective cohort study of a total of 1,293 patients transported from 2010 to 2013 by STAT MedEvac. Subjects had a suspected stroke, a prehospital NIHSS and a discharge diagnosis of stroke. The prehospital data were recorded in EMS charts by the EMS provider and used to establish scores for each of the four stroke scales analyzed. The hospital record was used to identify ischemic stroke (final discharge diagnosis) and the presence of LVO. Stroke identification and severity was determined by using the best cut off points for each of the scales. Using STATA12 the receiver operating characteristics were calculated for each scale. Conclusions: Prehospital stroke scales differ significantly in sensitivity and specificity for stroke and LVO identification with most scores having low sensitivity for both stroke and LVO detection. Although the commonly used CPSS has a fairly high sensitivity its specificity is low which could lead to a potential over-triage of patients. The results of the study show that none of these scales has sufficient accuracy to identify strokes and eliminate stroke mimics. A new tool is needed to improve prehospital stroke and LVO.
Historial de los brotes de triquinosis ligados al consumo de carne de caballo, 1975-1998
Authors: T Ancelle
Journal: Eurosurveillance (1998)

La triquinosis es una enfermedad parasitaria que se transmite a los seres humanos por consumo de carne cruda o poco cocinada de animales contaminados por larvas del genero Trichinella. En la naturaleza, el ciclo biologico implica a la mayoria de los carnivoros, omnivoros y numerosos roedores. Los animales domesticos tambien pueden estar infectados, sobre todo los cerdos (1).
Un'epidemia di cheratocongiuntivite da Adenovirus tipo 8 in una casa di riposo a Madrid, 2001-2002
Authors: J M Sendra Gutierrez, D Martin Rios, I Casas, P Sáez, A Tovar, C Moreno
Journal: Eurosurveillance (2004)

Questo lavoro descrive e analizza un'epidemia di cheratocongiuntivite avvenuta nel 2001 e nel 2002 in una casa di riposo per anziani a Leganes (un'area di Madrid). E' il primo caso pubblicato in Spagna con queste caratteristiche e l'identificazione di questo sierotipo. 
Sono descritte le caratteristiche sociodemografiche, la curva epidemica e i tassi di attacco. I confronti fra i dati sono stati eseguiti usando il test del ?2 per le variabili qualitative e il t test per quelle quantitative. I fattori associati alla malattia sono stati analizzati per mezzo di tabelle di contingenza e modelli di regressione logistica.
Sono stati scoperti 102 casi, con un tasso di attacco del 36,4% per i residenti e 12,9% per gli operatori, senza considerare differenze spaziali o professionali. La curva epidemica ha mostrato un profilo di trasmissione interpersonale. L'analisi multivariata ha identificato i seguenti fattori di rischio tra i residenti: capacita di girare liberamente per la struttura, incontinenza urinaria e uso di bagno in comune. Nel 34,6% dei campioni congiuntivali, e stato ritrovato adenovirus di sierotipo 8 con sequenza genomica identica.
Fattori chiave per la prevenzione e il controllo di queste epidemie in comunita chiuse sono l'istituzione di una guida igienico-sanitaria per la pulizia di tali strutture e il contatto con i residenti, come pure una diagnosi precoce e un buon coordinamento delle risorse umane e materiali.
Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX
Authors: Joseph Lau, Kuo-Shyan Lin, François Bénard
Journal: Theranostics (2017)

Theranostics is the integration of diagnostic information with pharmaceuticals to increase effectiveness and safety of cancer treatments.Nuclear medicine provides a non-invasive means to visualize drug target expression across primary and metastatic sites, and assess pharmacokinetics and efficacy of companion therapeutic agents.This is significant given the increasing recognition of the importance of clonal heterogeneity in treatment response and resistance.Carbonic anhydrase IX (CA-IX) has been advocated as an attractive diagnostic and therapeutic biomarker for targeting hypoxia in solid malignancies.CA-IX confers cancer cell survival under low oxygen tension, and is associated with increased propensity for metastasis.As such, CA-IX is overexpressed in a broad spectrum of cancers.Different classes of antigen recognition molecules targeting CA-IX including monoclonal antibodies, peptides, small molecule inhibitors, and antibody mimetics have been radiolabeled for imaging and therapeutic applications.cG250, a chimeric monoclonal antibody, has been labeled with an assortment of radionuclides ( 124 I, 111 In, 89 Zr, 131 I, 90 Y, and 177 Lu) and is the most extensively investigated CA-IX radiopharmaceutical.In recent years, there have been tremendous advancements made by the research community in developing alternatives to cG250.Although still in preclinical settings, several small molecule inhibitors and antibody mimetics hold great promise in improving the management of aggressive and resistant cancers.
TCT-429 Comparison of the clinical performance between COMBO and Xience stent at one year follow-up in all-comers patients
Authors: Deborah Kalkman, Ruben Tijssen, Joelle Elias, Ivo M. van Dongen, Robin Kraak, Pier Woudstra, M. Beijk, Jan Tijssen, Jan Piek, Jose PS. Henriques, Robbert de Winter, Joanna Wykrzykowska
Journal: Journal of the American College of Cardiology (2017)
Vaccination antigrippale en Europe :comment toucher les populations cibles et optimiser les vaccinations
Authors: S Cotter, F Ryan, H Hegarty, T. J McCabe, E Keane
Journal: Eurosurveillance (2003)

Une etude a ete menee pour evaluer la couverture vacci-nale antigrippale chez les groupes a risque, et les pratiques de vaccination dans les pays europeens. Les donnees de 26 pays ont ete collectees par questionnaires envoyes aux experts nationaux de
Abdominal Splenosis Mimicking Peritoneal Metastasis in Prostate-Specific Membrane Antigen PET/CT, Confirmed With Selective Spleen SPECT/CT
Authors: Emre Demirci, Duygu Has Simsek, Levent Kabasakal, Mehmet Mülazimoğlu
Journal: Clinical Nuclear Medicine (2017)

Abstract 68 Ga–prostate-specific membrane antigen (PSMA) PET/CT is a rapidly evolving diagnostic technique to image prostate cancer. In contrast to the name PSMA, various tissues show 68 Ga-PSMA uptake in PET/CT imaging. We present a case of a 68-year-old man with prostate cancer who underwent Ga-PSMA PET/CT. Along with metastatic lymph nodes, multiple nodular lesions within the peritoneal spaces of all 4 quadrants of the abdomen showed high PSMA expression. Because of a history of splenic rupture, a 99m Tc-labeled heat-denatured erythrocyte scintigraphy and SPECT were performed. Peritoneal lesions showed high uptake, confirming widespread peritoneal splenosis.
Safety and tolerability of the anti-IGF-I receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in patients with advanced solid tumors
Authors: Michael Pollak, P Eisenberg, D Karp, R Cohen, H Kreisman, A Adjei, C Langer, C. Melvin, D Yin, A Gualberto
Journal: Cancer Research (2007)

LB-343  Background: The paradigm of using therapeutic antibodies to target growth factor receptors is now well established in Oncology; a key example is targeting the HER2 receptor with trastuzumab. Experimental data provide a strong rationale for targeting the insulin-like growth factor I receptor (IGF-IR). Preclinical models involving genetic approaches to attenuate IGF-IR signaling suggest that this pathway is a key activator of the AKT pathway in many tumor types, and that ablation of IGF-IR signaling can induce apoptoisis and/or chemosensitize certain cancer cells to a degree similar to or greater than that achieved by targeting other tyrosine kinase receptors. CP-751,871 is a fully human, IgG2 monoclonal antibody that induces a rapid and selective downregulation of the insulin like growth factor I receptor (IGF-IR). Pre-clinical studies provide evidence that this antibody reduces neoplastic growth and sensitizes cancer cells to cytotoxic agents. We report clinical trial results concerning the safety, tolerability, pharmacokinetics and pharmacodynamics of CP-751,871 in combination with paclitaxel (T), carboplatin (C) in patients with advanced solid tumors. Methods: Patients received T (200 mg/m2), C (AUC of 6) and escalating doses of CP-751,871 (0.05-10 mg/kg) every 3 weeks for up to 6 cycles; patients with response or stable disease could receive extended CP-751,871 therapy. Results: Seven cohorts with a total of 30 patients, including 23 NSCLC patients, were enrolled. No dose limiting toxicities were identified and the maximal feasible dose cohort of 10 mg/kg was extended to 12 patients. One case of grade 3 GGT elevation attributed to CP-751,871 was reported. Grade 2 adverse events attributed to CP-751,871 were: muscle pain (reported in 2 patients), diarrhea (2 patients), anemia (2 patients), asthenia (1 patient) and orthostatic hypotension (1 patient). The most common grade 1 toxicities were fatigue (4 patients), anorexia (2 patients), headache (2 patients) and diarrhea (2 patients). CP-751,871 exposure parameters increased with dose, and preliminary pharmacokinetic data are consistent with target-mediated disposition and show that IGF-I and IGF-IR levels were modulated in a dose-dependent manner, with elevations in IGF-I levels and reduction in IGF-IR levels consistent with active in vivo IGF-IR targeting. Responses were seen in this phase I study, and one NSCLC patient continues on study at cycle 30. Conclusions: CP-751,871 is well tolerated in combination with chemotherapy. Phase II studies are justified, and their design will be described.
Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial
Authors: Nancy L. Bartlett, Brian A. Costello, Betsy R. LaPlant, Stephen M. Ansell, John G. Kuruvilla, Craig B. Reeder, Lim S. Thye, Daniel M. Anderson, Kilannin Krysiak, Cody Ramirez, Jing Qi, Barry A. Siegel, Malachi Griffith, Obi L. Griffith, Felicia Gomez, Todd A. Fehniger
Journal: Blood (2017)