tbuckley/cabot-search huggingface dataset:
slan+ Monocytes and Macrophages Mediate CD20-Dependent B-cell Lymphoma Elimination via ADCC and ADCP
Authors: William Vermi, Alessandra Micheletti, Giulia Finotti, Cristina Tecchio, Federica Calzetti, Sara Costa, Mattia Bugatti, Stefano Calza, Claudio Agostinelli, Stefano Pileri, Piera Balzarini, Alessandra Tucci, Giuseppe Rossi, Lara Furlani, Giuseppe Todeschini, Alberto Zamò, Fabio Facchetti, Luisa Lorenzi, Silvia Lonardi, Marco A. Cassatella
Journal: Cancer Research (2018)

Abstract Terminal tissue differentiation and function of slan+ monocytes in cancer is largely unexplored. Our recent studies demonstrated that slan+ monocytes differentiate into a distinct subset of dendritic cells (DC) in human tonsils and that slan+ cells colonize metastatic carcinoma-draining lymph nodes. Herein, we report by retrospective analysis of multi-institutional cohorts that slan+ cells infiltrate various types of non-Hodgkin lymphomas (NHL), particularly the diffuse large B-cell lymphoma (DLBCL) group, including the most aggressive, nodal and extranodal, forms. Nodal slan+ cells displayed features of either immature DC or macrophages, in the latter case ingesting tumor cells and apoptotic bodies. We also found in patients with DLBCL that peripheral blood slan+ monocytes, but not CD14+ monocytes, increased in number and displayed highly efficient rituximab-mediated antibody-dependent cellular cytotoxicity, almost equivalent to that exerted by NK cells. Notably, slan+ monocytes cultured in conditioned medium from nodal DLBCL (DCM) acquired a macrophage-like phenotype, retained CD16 expression, and became very efficient in rituximab-mediated antibody-dependent cellular phagocytosis (ADCP). Macrophages derived from DCM-treated CD14+ monocytes performed very efficient rituximab-mediated ADCP, however, using different FcγRs from those used by slan+ macrophages. Our observations shed new light on the complexity of the immune microenvironment of DLBCL and demonstrate plasticity of slan+ monocytes homing to cancer tissues. Altogether, data identify slan+ monocytes and macrophages as prominent effectors of antibody-mediated tumor cell targeting in patients with DLBCL. Significance: slan+ monocytes differentiate into macrophages that function as prominent effectors of antibody-mediated tumor cell targeting in lymphoma. Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/78/13/3544/F1.large.jpg. Cancer Res; 78(13); 3544–59. ©2018 AACR.
Abstract 16440: A Quantitative Appraisal of Recommendations Regarding Multi-vessel Intervention in ST-elevation Myocardial Infarction: Insights From the US Nationwide Inpatient Sample and an Updated Comprehensive Meta-analysis of Observational Data
Authors: Saurav Chatterjee, Robert W Yeh, Partha Sardar, Debabrata Mukherjee, Jay Giri
Journal: Circulation (2015)

Introduction: Current recommendations based largely on observational data state that multi-vessel percutaneous coronary intervention (MVPCI) in STEMI at time of initial hospitalization may be harmful. Hypothesis: MVPCI is not associated with higher in-hospital mortality in a large contemporary national dataset, and has never been. Methods: We queried the Nationwide Inpatient Sample (NIS) which includes in-hospital outcomes for 20% of all hospitalizations across US to identify mortality associated with MV-PCI for STEMI in unadjusted, multi-variable and propensity adjusted models. Published observational studies comparing in-hospital mortality with MV-PCI in contrast with infarct-related artery (IRA) only PCI were also pooled. Odds ratios (OR) and respective 95% confidence intervals (CI) were reported in a random effects model. Results were validated with study sequential analyses. Results: From 2009-2012-there were 11,454 MVPCI and 157,011 single-vessel PCI (SVPCI) for STEMI patients in the NIS. Mortality was 1.91% for MVPCI Vs 8.9% for SVPCI in the unadjusted analysis (OR 0.20, 95% CI 0.17-0.23). In a multivariable model(OR 0.28, 95% CI 0.24-0.33) and 1:3 propensity matched model (1.91% vs. 5.32%, OR 0.28, 95% CI 0.24-0.32)results were similar. Our analysis of index hospitalization MVPCI versus infarct-related artery (IRA) - only PCI in the comprehensive meta-analysis of observational studies (19 studies, N=76,399), demonstrated no difference in in-hospital mortality with MVPCI (5.3%) compared with IRA-only PCI (5.06%)(OR 0.87, 95% CI 0.65-1.17; p=0.37).Study sequential analyses confirmed our results.(Figure) Conclusion: MVPCI is very rarely performed on the index hospitalization in a contemporary cohort of STEMI patients in the US reflecting adherence to current guidelines. Based on all available observational data, there does not appear to be early harm associated with MVPCI in STEMI.
Results of a randomised controlled trial of budesonide add-on therapy in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid
Authors: G. Hirschfield, L. Kupcinskas, P. Ott, U. Beuers, A.M. Bergquist, M. Färkkilä, M.P. Manns, A. Pares, U. Spengler, R. Greinwald, M. Proels, R. Poupon
Journal: Journal of Hepatology (2018)
Comorbidities in chronic hepatitis B patients currently treated with nucleos(t)ide analogues
Authors: S.(S.) Siakavellas, I. Goulis, S. Manolakopoulos, C. Triantos, Z. Kalliopi, E. Tsentemidou, H. Kranidioti, K. Zisimopoulos, C. Tsoulas, G. Dalekos, G. Papatheodoridis
Journal: Journal of Hepatology (2018)
P125Lack of neuregulin-1 expression is associated with CD31 shedding on cardiac microvascular endothelial cells of patients suffering from post-ischemic heart failure
Authors: V Syvannarath, M Morvan, G Even, G Franck, C Deschildre, L Deschamps, P Nataf, J B Michel, A Nicoletti, G Caligiuri
Journal: Cardiovascular Research (2018)
“All of Us” study begins to sequence and follow a million Americans
Authors: Owen Dyer
Journal: BMJ (2018)

The much anticipated All of Us programme, a large prospective study, will begin general recruitment on 6 May with events in seven US cities, the National Institutes of Health (NIH) has announced.1 Francis Collins, NIH director, called it “a national adventure that is going to transform medical care.”

Initially set to run for 10 years, the All of Us study will be exceptional not just for its million strong population but for the sheer quantity of …
A Modern Framework for Transfer of Simulation-Based Training to the Operating Room for Practicing Surgeons
Authors: Stephanie Zajac, Brian J. Dunkin
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Association Between Prescription Drug Monitoring Programs and Nonfatal and Fatal Drug Overdoses
Authors: David S. Fink, Julia P. Schleimer, Aaron Sarvet, Kiran K. Grover, Chris Delcher, Alvaro Castillo-Carniglia, June H. Kim, Ariadne E. Rivera-Aguirre, Stephen G. Henry, Silvia S. Martins, Magdalena Cerdá
Journal: Annals of Internal Medicine (2018)

Prescription drug monitoring programs (PDMPs) are a key component of the president's Prescription Drug Abuse Prevention Plan to prevent opioid overdoses in the United States.
Extended screening for infectious diseases among newly arrived asylum seekers from Africa and Asia, Verona province, Italy, April 2014 to June 2015
Authors: Dora Buonfrate, Federico Gobbi, Valentina Marchese, Chiara Postiglione, Geraldo Badona Monteiro, Giovanni Giorli, Giuseppina Napoletano, Zeno Bisoffi
Journal: Eurosurveillance (2018)

Background and aim Management of health issues presented by newly arrived migrants is often limited to communicable diseases even though other health issues may be more prevalent. We report the results of infectious disease screening proposed to 462 recently-arrived asylum seekers over 14 years of age in Verona province between April 2014 and June 2015. Methods: Screening for latent tuberculosis (TB) was performed via tuberculin skin test (TST) and/or QuantiFERON-TB Gold in-tube assay and/or chest X-ray. An ELISA was used to screen for syphilis. Stool microscopy was used to screen for helminthic infections, and serology was also used for strongyloidiasis and schistosomiasis. Screening for the latter also included urine filtration and microscopy. Results: Most individuals came from sub-Saharan Africa (77.5%), with others coming from Asia (21.0%) and North Africa (1.5%). The prevalence of viral diseases/markers of human immunodeficiency virus (HIV) infection was 1.3%, HCV infection was 0.85% and hepatitis B virus surface antigen was 11.6%. Serological tests for syphilis were positive in 3.7% of individuals. Of 125 individuals screened for TB via the TST, 44.8% were positive and of 118 screened via the assay, 44.0% were positive. Of 458 individuals tested for strongyloidiasis, 91 (19.9%) were positive, and 76 of 358 (21.2%) individuals from sub-Saharan Africa were positive for schistosomiasis. Conclusions: The screening of viral diseases is questionable because of low prevalence and/or long-term, expensive treatments. For opposing reasons, helminthic infections are probably worth to be targeted by screening strategies in asylum seekers of selected countries of origin.
Comparison of efficacy between sorafenib monotherapy vs. transarterial chemoembolization – sorafenib sequential therapy in hepatocellular carcinoma patients with extrahepatic metastatis – An interim analysis of randomized controlled trial
Authors: H.J. Yim, S.J. Suh, Y.K. Jung, S.B. Cho, W.J. Chung, Y.S. Kim, S.H. Bae, J.Y. Park
Journal: Journal of Hepatology (2018)
Development of self-renewing 3D organoid culture from human fetal biliary tree stem cells (hBTSCs) as a potential system for regenerative medicine and disease modelling
Authors: S. Safarikia, V. Cardinale, G. Carpino, D. Costantini, S. DI Matteo, L. Nevi, D. Bosco, E. Gaudio, D. Alvaro
Journal: Journal of Hepatology (2018)
Predicting Outcomes in Idiopathic Pulmonary Fibrosis Using Automated Computed Tomographic Analysis
Authors: Joseph Jacob, Brian J. Bartholmai, Srinivasan Rajagopalan, Coline H. M. van Moorsel, Hendrik W. van Es, Frouke T. van Beek, Marjolijn H. L. Struik, Maria Kokosi, Ryoko Egashira, Anne Laure Brun, Arjun Nair, Simon L. F. Walsh, Gary Cross, Joseph Barnett, Angelo de Lauretis, Eoin P. Judge, Sujal Desai, Ronald Karwoski, Sebastien Ourselin, Elisabetta Renzoni, Toby M. Maher, Andre Altmann, Athol U. Wells
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Rationale: Quantitative computed tomographic (CT) measures of baseline disease severity might identify patients with idiopathic pulmonary fibrosis (IPF) with an increased mortality risk. We evaluated whether quantitative CT variables could act as a cohort enrichment tool in future IPF drug trials.Objectives: To determine whether computer-derived CT measures, specifically measures of pulmonary vessel–related structures (VRSs), can better predict functional decline and survival in IPF and reduce requisite sample sizes in drug trial populations.Methods: Patients with IPF undergoing volumetric noncontrast CT imaging at the Royal Brompton Hospital, London, and St. Antonius Hospital, Utrecht, were examined to identify pulmonary function measures (including FVC) and visual and computer-derived (CALIPER [Computer-Aided Lung Informatics for Pathology Evaluation and Rating] software) CT features predictive of mortality and FVC decline. The discovery cohort comprised 247 consecutive patients, with validation of results conducted in a separate cohort of 284 patients, all fulfilling drug trial entry criteria.Measurements and Main Results: In the discovery and validation cohorts, CALIPER-derived features, particularly VRS scores, were among the strongest predictors of survival and FVC decline. CALIPER results were accentuated in patients with less extensive disease, outperforming pulmonary function measures. When used as a cohort enrichment tool, a CALIPER VRS score greater than 4.4% of the lung was able to reduce the requisite sample size of an IPF drug trial by 26%.Conclusions: Our study has validated a new quantitative CT measure in patients with IPF fulfilling drug trial entry criteria—the VRS score—that outperformed current gold standard measures of outcome. When used for cohort enrichment in an IPF drug trial setting, VRS threshold scores can reduce a required IPF drug trial population size by 25%, thereby limiting prohibitive trial costs. Importantly, VRS scores identify patients in whom antifibrotic medication prolongs life and reduces FVC decline.
Multicentre study evaluating matrix-assisted laser desorption ionization–time of flight mass spectrometry for identification of clinically isolated Elizabethkingia species and analysis of antimicrobial susceptibility
Authors: Y.-H. Cheng, C.-L. Perng, M.-J. Jian, Y.-H. Cheng, S.-Y. Lee, J.-R. Sun, H.-S. Shang
Journal: Clinical Microbiology and Infection (2018)
The effectiveness of a pharmacological intervention for defatting of primary human hepatocytes and its effect on other cell types of the liver: a precursor in-vitro study to the defatting of steatotic human livers using normothermic machine perfusion
Authors: Y. Boteon, L. Wallace, R. Bhogal, A. Boteon, R. Laing, G. Reynolds, D.F. Mirza, H. Mergental, S. Afford
Journal: Journal of Hepatology (2018)
P376The administration of a mitochondrial antioxidant protects against the cardiac consequences associated with obesity in rats
Authors: G Marin-Royo, S Jimenz-Gonzalez, R Jurado-Lopez, I E Avila-Heredia, E Lagunas, M Luaces, F Islas, M L Nieto, V Cachofeiro
Journal: Cardiovascular Research (2018)
Patient (pt) characteristics and treatment patterns in the radium (Ra)-223 REASSURE observational study
Authors: S. Baldari, V. Annibale, S. Lastoria, M. Tucci, E. Borsatti, F. Monari, G. Paganelli, E. Verri, P. Muto, S. Panareo, A. Mosca, G. Storto, A. Bagnato, M. Farsad, D. Bilancia, P. Marchetti, C. Sternberg, G. Procopio, E. Seregni, R. Valdagni
Journal: Annals of Oncology (2017)
Why Bioethics Should Be Concerned With Medically Unexplained Symptoms
Authors: Diane O'Leary
Journal: The American Journal of Bioethics (2018)

Biomedical diagnostic science is a great deal less successful than we've been willing to acknowledge in bioethics, and this fact has far-reaching ethical implications. In this article I consider the surprising prevalence of medically unexplained symptoms, and the term's ambiguous meaning. Then I frame central questions that remain answered in this context with respect to informed consent, autonomy, and truth-telling. Finally, I show that while considerable attention in this area is given to making sure not to provide biological care to patients without a need, comparatively little is given to the competing, ethically central task of making sure never to obstruct access to biological care for those with diagnostically confusing biological conditions. I suggest this problem arises from confusion about the philosophical value of vagueness when it comes to the line between biological and psychosocial needs.
Can HCV be eliminated among HIV-infected MSM in Berlin? Modeling a setting with increasing incidence and high treatment rates
Authors: N. Martin, K. Jansen, M. an der Heiden, C. Boesecke, A. Boyd, K. Schewe, A. Baumgarten, T. Lutz, S. Christensen, A. Thielen, S. Mauss, J. Rockstroh, P. Ingiliz
Journal: Journal of Hepatology (2018)
Relationship between hepatitis B core-related antigen and chronic hepatitis B outcome in HBeAg negative patients: a 10-year longitudinal study
Authors: W. Pan To, D. Wong, L.-Y. Mak, W.-K. Seto, K.-S. Cheung, Y. Yue, J. Fung, C. Lung Lai, M.-F. Yuen
Journal: Journal of Hepatology (2018)
Two cases of generalized pustular psoriasis complicated by IgG4-related disease
Authors: H. Miyazawa, Y. Fujita, H. Iwata, Y. Ishikawa, S. Nishio, K. Ishijima, Y. Shinmei, T. Takeichi, K. Goto, R. Oi, M. Akiyama, H. Shimizu
Journal: British Journal of Dermatology (2018)
Progress in Understanding and Treating SCN2A-Mediated Disorders
Authors: Stephan J. Sanders, Arthur J. Campbell, Jeffrey R. Cottrell, Rikke S. Moller, Florence F. Wagner, Angie L. Auldridge, Raphael A. Bernier, William A. Catterall, Wendy K. Chung, James R. Empfield, Alfred L. George, Joerg F. Hipp, Omar Khwaja, Evangelos Kiskinis, Dennis Lal, Dheeraj Malhotra, John J. Millichap, Thomas S. Otis, Steven Petrou, Geoffrey Pitt, Leah F. Schust, Cora M. Taylor, Jennifer Tjernagel, John E. Spiro, Kevin J. Bender
Journal: Trends in Neurosciences (2018)
Health in a bar of soap
Authors: Alison Shepherd
Journal: BMJ (2018)

WaterAid

Chanthou teaches her children, Sovannreach, 7, and Narong, 3, how to wash their hands after receiving soap from Tuol Snoul Health Centre in Cambodia.

The family are part of a project developed by the global health charities WaterAid and PATH aimed at encouraging governments to combine …
Evaluation of Intussusception after Monovalent Rotavirus Vaccination in Africa
Authors: Jacqueline E. Tate, Jason M. Mwenda, George Armah, Bhavin Jani, Richard Omore, Ayesheshem Ademe, Hilda Mujuru, Evans Mpabalwani, Bagrey Ngwira, Margaret M. Cortese, Richard Mihigo, Hope Glover-Addy, Mwajabu Mbaga, Francis Osawa, Amezene Tadesse, Bothwell Mbuwayesango, Julia Simwaka, Nigel Cunliffe, Benjamin A. Lopman, Goitom Weldegebriel, Daniel Ansong, David Msuya, Billy Ogwel, Thomas Karengera, Portia Manangazira, Bruce Bvulani, Catherine Yen, Felicitas R. Zawaira, Clement T. Narh, Lazaro Mboma, Peter Saula, Fasil Teshager, Halle Getachew, Rebecca M. Moeti, Christabel Eweronu-Laryea, Umesh D. Parashar
Journal: New England Journal of Medicine (2018)

Postlicensure evaluations have identified an association between rotavirus vaccination and intussusception in several high- and middle-income countries. We assessed the association between monovalent human rotavirus vaccine and intussusception in lower-income sub-Saharan African countries.Using active surveillance, we enrolled patients from seven countries (Ethiopia, Ghana, Kenya, Malawi, Tanzania, Zambia, and Zimbabwe) who had intussusception that met international (Brighton Collaboration level 1) criteria. Rotavirus vaccination status was confirmed by review of the vaccine card or clinic records. The risk of intussusception within 1 to 7 days and 8 to 21 days after vaccination among infants 28 to 245 days of age was assessed by means of the self-controlled case-series method.Data on 717 infants who had intussusception and confirmed vaccination status were analyzed. One case occurred in the 1 to 7 days after dose 1, and 6 cases occurred in the 8 to 21 days after dose 1. Five cases and 16 cases occurred in the 1 to 7 days and 8 to 21 days, respectively, after dose 2. The risk of intussusception in the 1 to 7 days after dose 1 was not higher than the background risk of intussusception (relative incidence [i.e., the incidence during the risk window vs. all other times], 0.25; 95% confidence interval [CI], <0.001 to 1.16); findings were similar for the 1 to 7 days after dose 2 (relative incidence, 0.76; 95% CI, 0.16 to 1.87). In addition, the risk of intussusception in the 8 to 21 days or 1 to 21 days after either dose was not found to be higher than the background risk.The risk of intussusception after administration of monovalent human rotavirus vaccine was not higher than the background risk of intussusception in seven lower-income sub-Saharan African countries. (Funded by the GAVI Alliance through the CDC Foundation.).
Analysis of DNA methylation in cancer: location revisited
Authors: Alexander Koch, Sophie C. Joosten, Zheng Feng, Tim C. de Ruijter, Muriel X. Draht, Veerle Melotte, Kim M. Smits, Jurgen Veeck, James G. Herman, Leander Van Neste, Wim Van Criekinge, Tim De Meyer, Manon van Engeland
Journal: Nature Reviews Clinical Oncology (2018)
Primary biliary cholangitis in Spain: fewer symptoms and milder disease at presentation, but similar therapeutic response over the years
Authors: A. Reig, L.P. Llovet, M.R. Gomez, F. Sáez-Royuela, E. Fábrega, J. Salmerón, D. Horta, A. Castano-Garcia, A. Albillos, R.J. Andrade, M. Sala, J.A. Carrión, E.G. Domínguez, N. Chahri, I. Conde, A.G. Moya, M.H. Conde, M. Diago, A. Pares
Journal: Journal of Hepatology (2018)
Depression and anxiety in patients with cancer
Authors: Alexandra Pitman, Sahil Suleman, Nicholas Hyde, Andrew Hodgkiss
Journal: BMJ (2018)

### What you need to know

Advances in cancer treatments mean that half of people now diagnosed with cancer can expect to survive for at least 10 years,1 defining many cancers as long term conditions. Psychiatric illnesses such as depression and anxiety are common, but often neglected, complications of cancer, influencing quality of life, adherence to treatment, cancer survival, and treatment costs.23 Depression and anxiety affect up to 20% and 10% of patients with cancer respectively, regardless of the point in the cancer trajectory, and whether in curative or palliative treatment.4 Geographical variations in the diagnosis and treatment of depression or anxiety in cancer settings implies under-recognition of these problems.5 Depression is associated with poor adherence to cancer treatment and poor cancer survival,6 and the increased risk of suicide in all patients with cancer7 is a concern.

This clinical update outlines the prevalence, aetiology, and management of depression and anxiety in patients with cancer to raise awareness among doctors of the need to address the psychiatric consequences of cancer.

### Sources and selection criteria

We conducted tumour-specific and treatment-specific PubMed searches, and used NICE …
Eficacia y seguridad de terapia de vacío endoluminal en el tratamiento de dehiscencias anastomóticas colorrectales. Serie de casos
Authors: M Fraile López, A Gómez Outomuro, M Torner Simó, A Castaño García, R Fernández Velázquez, MA Palacio Galán, OL González Bernardo, C Riesgo Rubio, A Toledo Soriano, A Suárez González
Journal: Endoscopy (2017)

La terapia de vacío endoluminal (Endo-SPONGE®) es un método mínimamente invasivo para el tratamiento de dehiscencias anastomóticas colorrectales bajas. Consiste en una esponja de poros abiertos de poliuretano conectada a un tubo de drenaje y una botella de bajo vacío. La presión negativa localizada facilita el drenaje de la cavidad, controla el edema y estimula el tejido de granulación favoreciendo el cierre de la fístula.
Effect of B-blockers on the systemic hemodynamics of decompensated cirrhosis and survival
Authors: E. Alvarado, B. Cuyas, M. García Guix, A. Ardevol, R. Montañés, M. Poca, M. Concepciòn, S. Bazaga, G. Iborra, C. Aracil, X. Torras, C. Guarner, C. Villanueva
Journal: Journal of Hepatology (2018)