tbuckley/cabot-search huggingface dataset:
Nintedanib plus docetaxel in routine clinical practice: VARGADO, a German prospective non-interventional study (NIS) reflecting routine treatment conditions in an evolving NSCLC treatment landscape
Authors: C. Grohe, I. Zander, K. Lüdtke-Heckenkamp, W. Blau, S. Krüger, C. Franke, H. Mueller-Huesmann, W.M. Brückl, N. Basara, D. Ukena, S. Lang, J. Atz, R. Kaiser
Journal: Annals of Oncology (2018)
P3.08-12 Long-Term Outcome After Adrenalectomy for Isolated Adrenal Metastasis in Otherwise Operable Patients With NSCLC - Two Institutions Study
Authors: D. Petrov, A. Semkov, D. Djuric, E. Naseva, G. Yankov, S. Shumarova, G. Todorov
Journal: Journal of Thoracic Oncology (2018)
P3.16-41 Postoperative Pembrolizumab for the Patients with Pathologic Stage I Adenocarcinoma with Solid or Micropapillary Pattern
Authors: S. Shin, S. Lee, Y. Choi, J.H. Cho, H.K. Kim, Y.S. Choi, J. Han, J. Sun, J.S. Ahn, M. Ahn, K. Park, J.I. Zo, Y.M. Shim, J. Kim
Journal: Journal of Thoracic Oncology (2018)
Abstract 18329: Unsupervised Hierarchical Cluster Analysis of Combined Metabolomic and Proteomic Profiling Data Sets From Participants in a Community-Based Cohort Study
Authors: Daniel H Katz, Mark D Benson, Qiong Yang, Michelle J Keyes, Dongxiao Shen, Sumita Sinha, Jordan E Morningstar, Debby Ngo, John F O’Sullivan, Xu Shi, Laurie A Farrell, Ramachandran S Vasan, Thomas J Wang, Robert E Gerszten
Journal: Circulation (2016)

Introduction: The integration of metabolomic and proteomic profiling data sets from large cohorts promises to identify novel molecular pathways and therapeutic targets in cardiovascular disease. We hypothesized that unsupervised hierarchical cluster analysis (HCA) of combined proteomic and metabolomic data sets would provide a framework for unbiased identification of novel protein-metabolite associations. Methods: We have previously measured 1129 proteins using the aptamer-based Somascan platform (Somalogic, Boulder, CO) and 239 metabolites using liquid chromatography tandem mass spectrometry in archived plasma samples collected from 899 participants of Exam 5 of the Framingham Heart Study Offspring Cohort. Data were normalized and standardized using the inverse transformation. HCA of all proteins and metabolites was performed with absolute Pearson correlation distance, followed by dendrogram formation using average agglomeration. This process was blinded to all clinical and demographic data. Adaptive bra...
Stem-cell based organ-on-a-chip models for diabetes research
Authors: Julia Rogal, Aline Zbinden, Katja Schenke-Layland, Peter Loskill
Journal: Advanced Drug Delivery Reviews (2018)

Diabetes mellitus (DM) ranks among the severest global health concerns of the 21st century. It encompasses a group of chronic disorders characterized by a dysregulated glucose metabolism, which arises as a consequence of progressive autoimmune destruction of pancreatic beta-cells (type 1 DM), or as a result of beta-cell dysfunction combined with systemic insulin resistance (type 2 DM). Human cohort studies have provided evidence of genetic and environmental contributions to DM; yet, these studies are mostly restricted to investigating statistical correlations between DM and certain risk factors. Mechanistic studies, on the other hand, aimed at re-creating the clinical picture of human DM in animal models. A translation to human biology is, however, often inadequate owing to significant differences between animal and human physiology, including the species-specific glucose regulation. Thus, there is an urgent need for the development of advanced human in vitro models with the potential to identify novel treatment options for DM. This review provides an overview of the technological advances in research on DM-relevant stem cells and their integration into microphysiological environments as provided by the organ-on-a-chip technology.
GW29-e1467 Assessment of the Association between Sex-specific Serum Gamma-glutamyltransferase and Incident of Hypertension in Non-Metabolic Syndrome Population: A Prospective Observational Study
Authors: Shengjie Wu, Dongjie Liang, Rui Zhou, Songjie Wang, Jian Zhou, Minghua Zheng, Weijian Huang
Journal: Journal of the American College of Cardiology (2018)
A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation
Authors: Sonia Ventura, Florencia Cano, Yashaswini Kannan, Felix Breyer, Michael J. Pattison, Mark S. Wilson, Steven C. Ley
Journal: The Journal of Experimental Medicine (2018)

TPL-2 MAP 3-kinase promotes inflammation in numerous mouse disease models and is an attractive anti-inflammatory drug target. However, TPL-2-deficient (Map3k8 -/-) mice develop exacerbated allergic airway inflammation to house dust mite (HDM) compared with wild type controls. Here, we show that Map3k8D270A/D270A mice expressing kinase dead TPL-2 had an unaltered response to HDM, indicating that the severe airway inflammation observed in Map3k8 -/- mice is not due to blockade of TPL-2 signaling and rather reflects a TPL-2 adaptor function. Severe allergic inflammation in TPL-2-deficient mice was likely due to reduced levels of ABIN-2 (TNIP2), whose stability depends on TPL-2 expression. Tnip2E256K knock-in mutation, which reduced ABIN-2 binding to A20, augmented the HDM-induced airway inflammation, but did not affect TPL-2 expression or signaling. These results identify ABIN-2 as a novel negative regulator of allergic airway responses and importantly indicate that TPL-2 inhibitors would not have unwanted allergic comorbidities.
Preliminary result of p1/2 study of ramucirumab plus nivolumab in patients with pretreated advanced gastric carcinoma
Authors: Taito Esaki, Hirokazu Shoji, Daisuke Takahari, Hiroki Hara, Nozomu Machida, Kengo Nagashima, Kazunori Aoki, Kazufumi Honda, Takahiro Miyamoto, Narikazu Boku, Ken Kato
Journal: Annals of Oncology (2018)
ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture system
Authors: Masaharu Noi, Ken-Ichi Mukaisho, Saori Yoshida, Shoko Murakami, Shinya Koshinuma, Takeshi Adachi, Yoshisato Machida, Masashi Yamori, Takahisa Nakayama, Gaku Yamamoto, Hiroyuki Sugihara
Journal: International Journal of Oral Science (2018)

To screen for additional treatment targets against tongue cancer, we evaluated the contributions of extracellular signal-related kinase (ERK), AKT and ezrin in cancer development. Immunohistochemical staining showed that ERK and ezrin expressions were significantly higher in invasive squamous cell carcinoma than in carcinoma in situ. To investigate the roles of ERK and ezrin in cancer development, we used the non-woven silica fibre sheet CellbedTM with a structure resembling the loose connective tissue morphology in a novel 3D culture system. We confirmed that the 3D system using CellbedTM accurately mimicked cancer cell morphology in vivo. Furthermore, cell projections were much more apparent in 3D-cultured tongue cancer cell lines than in 2D cultures. Typically, under conventional 2D culture conditions, F-actin and cortactin are colocalized in the form of puncta within cells. However, in the 3D-cultured cells, colocalization was mainly observed at the cell margins, including the projections. Projections containing F-actin and cortactin colocalization were predicted to be invadopodia. Although suppressing ezrin expression with small interfering RNA transfection caused no marked changes in morphology, cell projection formation was decreased, and the tumour thickness in vertical sections after 3D culture was markedly decreased after suppressing ERK activity because both the invasion ability and proliferation were inhibited. An association between cortactin activation as well as ERK activity and invadopodia formation was detected. Our novel 3D culture systems using Cellbed™ are simple and useful for in vitro studies before conducting animal experiments. ERK contributes to tongue cancer development by increasing both cancer cell proliferation and migration via cortactin activation.
Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell lung cancer
Authors: Keqiang Zhang, Jinhui Wang, Lu Yang, Yate-Ching Yuan, Tommy R. Tong, Jun Wu, Xinwei Yun, Melissa Bonner, Rajendra Pangeni, Zheng Liu, Tiger Yuchi, Jae Y. Kim, Dan J. Raz
Journal: Molecular Cancer (2018)

Dysregulated histone methyltransferase G9a may represent a potential cancer therapeutic target. The roles of G9a in tumorigenesis and therapeutics are not well understood in non-small cell lung cancer (NSCLC). Here we investigated the impact of G9a on tumor growth and signaling pathways in NSCLC.Immunohistochemistry analyzed G9a expression in NSCLC tissues. Both siRNA and selective inhibitor were used to target G9a. The impact of targeting G9a on key genes, signaling pathways and growth were investigated in NSCLC cells by RNA sequencing analysis, rescue experiments, and xenograft models.Overexpression of G9a (≥ 5% of cancer cells showing positive staining) was found in 43.2% of 213 NSCLC tissues. Multiple tumor-associated genes including HP1α, APC2 are differentially expressed; and signaling pathways involved in cellular growth, adhesion, angiogenesis, hypoxia, apoptosis, and canonical Wnt signaling pathways are significantly altered in A549, H1299, and H1975 cells upon G9a knockdown. Additionally, targeting G9a by siRNA-mediated knockdown or by a selective G9a inhibitor UNC0638 significantly inhibited tumor growth, and dramatically suppressed Wnt signaling pathway in vitro and in vivo. Furthermore, we showed that treatment with UNC0638 restores the expression of APC2 expression in these cells through promoter demethylation. Restoring HP1α and silencing APC2 respectively attenuated the inhibitory effects on cell proliferation and Wnt signaling pathway in cancer cells in which G9a was silenced or suppressed.These findings demonstrate that overexpressed G9a represents a promising therapeutic target, and targeting G9a potentially suppresses growth and Wnt signaling pathway partially through down-regulating HP1α and epigenetically restoring these tumor suppressors such as APC2 that are silenced in NSCLC.
GW29-e0177 Increased risk of ischemic stroke associated with new-onset atrial fibrillation complicating acute coronary syndrome: a systematic review and meta-analysis
Authors: Jiachen Luo, Hongqiang Li, Xiaoming Qin, Baoxin Liu, Jinlong Zhao, None Maihe Guli, Zhiqiang Li, Yidong Wei
Journal: Journal of the American College of Cardiology (2018)
Abstract P128: Serum Lipid Levels at Adolescence can Predict Adult Dyslipidemia in South Korea - The Kangwha Study
Authors: Jung H Lee, Hyeon C Kim, Dae R Kang, Il Suh
Journal: Circulation (2017)

Introduction: Several studies have examined tracking pattern of lipid profile level during long follow-up periods in Western countries. However, there have been few such studies in East Asia. Hypothesis: We assessed the hypothesis that there exists tracking pattern of lipid profile level from adolescence to adulthood, and lipid measurements in adolescence can predict adult dyslipidemia in South Korea. Methods: The Kangwha Study was a community-based prospective cohort study that started in 1986 in Kangwha County, South Korea . A total of 400 participants (54% women) whose serum total cholesterol, triglyceride, and high density lipoprotein (HDL) cholesterol level were measured at least once during adolescence (1992-1996), and repeatedly measured at least once during adulthood (2005-2015) were enrolled in our study. Body mass index, waist circumstance, and blood pressure were measured at all measurements. Family history of cardiovascular disease, smoking history, and presence of adult dyslipidemia were checked at adulthood. The tracking pattern of lipid profile level was determined by tracking coefficients (low: &lt;0.30; moderate: 0.30-0.59; moderately high: 0.60-0.89; high: ≥0.90). The tracking coefficients were calculated by Generalized Estimating Equation. The predictability of adult dyslipidemia was assessed by multiple logistic regression and area under curve (AUC) value. Additional analyses were performed to find out whether repeated lipid measurements during adolescence can enhance the predictability of adult dyslipidemia or not. Results: The presence of adult dyslipidemia was 26.3% (105 of 400). Mean age of study participants at enrollment is 13.8 years (SD, 1.6 years), and that at adulthood is 30.1 years (SD, 3.7 years). When adjusted for age, body mass index, waist circumstance, and blood pressure, the tracking coefficient of total cholesterol was 0.59 (95% confidence interval (CI), 0.54-0.63), that of triglyceride was 0.39 (95% CI, 0.28-0.49), and that of HDL cholesterol was 0.51 (95% CI, 0.46-0.55). The AUC value of our multiple logistic regression model on adult dyslipidemia without lipid profile levels at adolescence was 0.77 (95% CI, 0.72-0.83), and that with lipid profile levels at adolescence was 0.80 (95% CI, 0.75-0.85). P value for AUC comparison was significant (p=0.02). In additional analyses, using the average lipid profile levels in multiple lipid measurements at adolescence did not significantly improve the AUC value (p&gt;0.09). Conclusion: In conclusion, moderate tracking patterns of serum lipid profile level were shown in this study. Serum lipid profile measurements at adolescence could help the prediction of adult dyslipidemia. The results of this study supported the need of lipid profile screening at adolescence.
ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS
Authors: Jone López-Erauskin, Takahiro Tadokoro, Michael W. Baughn, Brian Myers, Melissa McAlonis-Downes, Carlos Chillon-Marinas, Joshua N. Asiaban, Jonathan Artates, Anh T. Bui, Anne P. Vetto, Sandra K. Lee, Ai Vy Le, Ying Sun, Mélanie Jambeau, Jihane Boubaker, Deborah Swing, Jinsong Qiu, Geoffrey G. Hicks, Zhengyu Ouyang, Xiang-Dong Fu, Lino Tessarollo, Shuo-Chien Ling, Philippe A. Parone, Christopher E. Shaw, Martin Marsala, Clotilde Lagier-Tourenne, Don W. Cleveland, Sandrine Da Cruz
Journal: Neuron (2018)

Through the generation of humanized FUS mice expressing full-length human FUS, we identify that when expressed at near endogenous murine FUS levels, both wild-type and ALS-causing and frontotemporal dementia (FTD)-causing mutations complement the essential function(s) of murine FUS. Replacement of murine FUS with mutant, but not wild-type, human FUS causes stress-mediated induction of chaperones, decreased expression of ion channels and transporters essential for synaptic function, and reduced synaptic activity without loss of nuclear FUS or its cytoplasmic aggregation. Most strikingly, accumulation of mutant human FUS is shown to activate an integrated stress response and to inhibit local, intra-axonal protein synthesis in hippocampal neurons and sciatic nerves. Collectively, our evidence demonstrates that human ALS/FTD-linked mutations in FUS induce a gain of toxicity that includes stress-mediated suppression in intra-axonal translation, synaptic dysfunction, and progressive age-dependent motor and cognitive disease without cytoplasmic aggregation, altered nuclear localization, or aberrant splicing of FUS-bound pre-mRNAs.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiIxMmRlZWFhNjg5NDM0ZDhkYzQwZmE3YTVkYjk0MDk3ZiIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4NjcxNzg2fQ.oWGg-0E0QC7xiVxxAdRu5p48JozVzEK08FcO4VcvSnGO-rRCfxnGxjjfpXUlmU_dGxJKbamAvz8CX7Z9P64Il-BEEQzawip8NDZqvj7IsVahdMCTEHzxJ3Gj6LVXt5SLjTw1tdAdnf7xZz9sxSptk012izHRwJM57W5gwpoBzVLNjfGhDL19Y9NHfSjrWb3qsCXlhzjuYGqyQDzUTjSJy6Y3x9pFQKS-zc1brUgdfHwtTTtN2YedKrWQr5RA4LVDG1245liEAPG8iYYBb-hV3Exg6UE7QqlZhYWmUMeCCFTRiaOQ7GFOquiRRbSrvy_VGyxIBz2wH46YiVmFXb4UWA(mp4, (114.81 MB) Download video
Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice
Authors: Naomi Benne, Janine van Duijn, Fernando Lozano Vigario, Romain J.T. Leboux, Peter van Veelen, Johan Kuiper, Wim Jiskoot, Bram Slütter
Journal: Journal of Controlled Release (2018)

Atherosclerosis is the predominant underlying pathology of many types of cardiovascular disease and is one of the leading causes of death worldwide. It is characterized by the retention of oxidized low-density lipoprotein (ox-LDL) in lipid-rich macrophages (foam cells) in the intima of arteries. Autoantigens derived from oxLDL can be used to vaccinate against atherosclerosis. However, a major challenge is the induction of antigen-specific Tregs in a safe and effective way. Here we report that liposomes containing the anionic phospholipid 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) induce Tregs that are specific for the liposomes' cargo. Mechanistically, we show a crucial role for the protein corona that forms on the liposomes in the circulation, as uptake of DSPG-liposomes by antigen-presenting cells is mediated via complement component 1q (C1q) and scavenger receptors (SRs). Vaccination of atherosclerotic mice on a western-type diet with DSPG-liposomes encapsulating an LDL-derived peptide antigen significantly reduced plaque formation by 50% and stabilized the plaques, and reduced serum cholesterol concentrations. These results indicate that DSPG-liposomes have potential as a delivery system in vaccination against atherosclerosis.
Quality-of-life (QoL) results from RAINFALL: A randomized, double-blind, placebo (PL)-controlled phase III study of cisplatin (Cis) plus capecitabine (Cape) or 5FU with or without ramucirumab (RAM) as first-line therapy for metastatic gastric or gastroesophageal junction (G-GEJ) cancer
Authors: I. Chau, S.-E. Al-Batran, A. Luft, R.D. Kowalyszyn, C.A. Hernandez, P. Pfeiffer, E. Wojcik, G. Bodoky, A. Madi, B. Brenner, F. De Vita, G. Folprecht, K. Peltola, S. Lorenzen, C. Denlinger, A. Liepa, M. Das, R. Wei, C.S. Fuchs
Journal: Annals of Oncology (2018)
隐性 XLI: 神经系统疾病的高患病率
Authors: B. Rodrigo-Nicolás, E. Bueno-Martínez, A. Martín-Santiago, J. Cañueto, A. Vicente, A. Torrelo, L. Noguera-Morel, A. Duat-Rodríguez, C. Jorge-Finnigan, I. Palacios-Álvarez, J.L. García-Hernández, D.F. Sebaratnam, R. González-Sarmiento, A. Hernández-Martín
Journal: British Journal of Dermatology (2018)

这项来自西班牙的研究涉及一组称为鱼鳞病的遗传病,在该病中皮肤呈异常鳞屑状。这里研究的特定类型是由 X 染色体上的缺陷基因引起并且通常影响男性,而女性携带者具有正常皮肤,因此便有了此名称:X 连锁隐性鱼鳞病 (XLI)。患有 XLI 的人缺乏类固醇硫酸酯酶 (STS),这是正常皮肤去角质所需的酶。受影响的男孩可能会很健康,但可能患有隐睾。通过医院数据库,作者确定了 30 名患有 XLI 的男性,并从医疗记录和电话访谈中获取信息,旨在了解这种相对罕见疾病的临床特征。29 名患者有正常的手掌,这是区分 XLI 与其他类型鱼鳞病的有用标记。10% 的患者接受了治疗隐睾的手术,30% 的患者患有注意力缺陷多动障碍 (ADHD),13% 的患者患有癫痫,这三个数字均高于一般人群(分别为 3%,7% 和 1%)。XLI 患者的癫痫发生在缺失整个 STS 基因的患者中,可能是由邻近基因的损伤引起的。相比之下, ADHD 发生在 STS 基因内具有小突变的男孩中,并且可能由 STS 缺乏对神经心理功能的直接生化作用引起。这些患者均无自闭症或智力障碍。有趣的是,其他研究表明,广泛用于治疗 ADHD 的药物哌甲酯可以逆转由 STS 缺乏引起的生化缺陷。正如德国 Traupe 教授在随附的评论中指出的那样, XLI 比我们之前想象的要复杂得多。
Decentered Crowdfunded Clinical Studies—Open a New Era of Medical Research
Authors: Huichuan Yu, Yanxin Luo
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Impact of liver tumor burden on therapeutic effect of 177Lu-dotatate treatment in NETTER-1 study
Authors: J. Strosberg, A. Hendifar, J.C. Yao, M. Kulke, T. O’Dorisio, M. Caplin, R.P. Baum, P. Kunz, T. Hobday, E. Wolin, E.S. Mittra, K. Oberg, P. Ruszniewski, B. Polack, B. He, D. Barton, P. Santaro, E. Krenning
Journal: Annals of Oncology (2018)
M7824 (MSB0011359C), a bifunctional fusion protein targeting PD-L1 and TGF-β, in patients (pts) with advanced SCCHN: Results from a phase I cohort
Authors: B.C. Cho, A. Daste, A. Ravaud, S. Salas, N. Isambert, E. McClay, A. Awada, C. Borel, J. Gulley, L. Ojalvo, C. Helwig, P.A. Rolfe, N. Penel
Journal: Annals of Oncology (2018)
EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease
Authors: David C. Thomas, Louis-Marie Charbonnier, Andrea Schejtman, Hasan Aldhekri, Eve L. Coomber, Elizabeth R. Dufficy, Anne E. Beenken, James C. Lee, Simon Clare, Anneliese O. Speak, Adrian J. Thrasher, Giorgia Santilli, Hamoud Al-Mousa, Fowzan S. Alkuraya, Talal A. Chatila, Kenneth G.C. Smith
Journal: Journal of Allergy and Clinical Immunology (2018)
Abstract 11210: Long-Term Survival After Coronary Artery Bypass Grafting: On-Pump versus Off-Pump Strategies
Authors: Jae Suk Yoo, Joon Bum Kim, Sung-Cheol Yun, Jae Woong Lim, Sung-Ho Jung, Suk Jung Choo, Hyun Song, Cheol Hyun Chung, Jae Won Lee
Journal: Circulation (2013)

Background: The influence of cardiopulmonary bypass strategies during coronary artery bypass grafting (CABG) on long-term survival has not been evaluated in a reasonably sized cohort. Methods: We e...
Detection of Hepatic Encephalopathy on 18F-FDG PET/CT Brain Images in a Patient With Decompensated Liver Cirrhosis
Authors: Kousik Vankadari, Bhagwant Rai Mittal, Rajender Kumar, Harmandeep Singh, Anish Bhattacharya, Radha Krishan Dhiman
Journal: Clinical Nuclear Medicine (2018)

Abstract We present a case of decompensated liver cirrhosis with ascites, which had history of asterixis, impaired balance with swaying gait along with mild irritability since 1 month. 18 F-fluorodeoxyglucose PET/CT (FDG-PET/CT) performed to rule out malignancy did not reveal any abnormal FDG avid lesion suspicious for malignancy but showed hypermetabolism in the bilateral basal ganglia and thalamus with reduced metabolism in cerebral cortices and cerebellum, suggesting hepatic encephalopathy.
An Intravenous Fish Oil–Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease
Authors: Lorenzo Anez‐Bustillos, Duy T. Dao, Alexis K. Potemkin, Antonio R. Perez‐Atayde, Bram P. Raphael, Alexandra N. Carey, Daniel S. Kamin, Jay R. Thiagarajah, McGreggor Crowley, Kathleen M. Gura, Mark Puder
Journal: Hepatology (2018)

Anez‐Bustillos, Lorenzo; Dao, Duy T.; Potemkin, Alexis K.; Perez‐Atayde, Antonio R.; Raphael, Bram P.; Carey, Alexandra N.; Kamin, Daniel S.; Thiagarajah, Jay R.; Crowley, McGreggor; Gura, Kathleen M.; Puder, Mark Author Information
Initial treatment in patients (pts) diagnosed with non-small cell lung cancer (NSCLC) in Denmark from 2005-2015: The SCAN-LEAF study
Authors: J.B. Sørensen, S. Ekman, P. Horvat, D. Layton, J. Kim, M. Rosenlund, A. Juarez-Garcia, M. Daumont, H.C. Jacobs, L. Lacoin, O.T. Brustugun, M. Planck
Journal: Annals of Oncology (2018)