Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement
Authors: Giuseppe Gargiulo, Davide Capodanno, Corrado Tamburino, Bruno Trimarco, Giovanni Esposito
Journal: Annals of Internal Medicine (2017)

Letters18 April 2017Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve ReplacementGiuseppe Gargiulo, MD, Davide Capodanno, MD, PhD, Corrado Tamburino, MD, PhD, Bruno Trimarco, MD, PhD, and Giovanni Esposito, MD, PhDGiuseppe Gargiulo, MDFrom Federico II University, Naples, and Ferrarotto Hospital, University of Catania, Catania, Italy.Search for more papers by this author, Davide Capodanno, MD, PhDFrom Federico II University, Naples, and Ferrarotto Hospital, University of Catania, Catania, Italy.Search for more papers by this author, Corrado Tamburino, MD, PhDFrom Federico II University, Naples, and Ferrarotto Hospital, University of Catania, Catania, Italy.Search for more papers by this author, Bruno Trimarco, MD, PhDFrom Federico II University, Naples, and Ferrarotto Hospital, University of Catania, Catania, Italy.Search for more papers by this author, and Giovanni Esposito, MD, PhDFrom Federico II University, Naples, and Ferrarotto Hospital, University of Catania, Catania, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0104 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Drs. Zhang and Xu that long-term outcomes represent the most-awaited information from future studies comparing TAVI with SAVR. Indeed, our study sets long-term mortality as a secondary exploratory end point to refrain from overinterpretation, and our conclusions focus on early and midterm follow-up considerations. Drs. Zhang and Xu should note our statement that the effects of TAVI on long-term mortality remain unclear and may reflect the individual underlying risk and the TAVI approach used. Our review is transparent in reporting that only matched studies with significant heterogeneity related to study design drove the observed nonsignificant ...References1. Siontis GC, Praz F, Pilgrim T, Mavridis D, Verma S, Salanti G, et al. Transcatheter aortic valve implantation vs. surgical aortic valve replacement for treatment of severe aortic stenosis: a meta-analysis of randomized trials. Eur Heart J. 2016;37:3503-12. [PMID: 27389906] doi:10.1093/eurheartj/ehw225 CrossrefMedlineGoogle Scholar2. Stewart LA, Clarke M, Rovers M, Riley RD, Simmonds M, Stewart G, et al; PRISMA-IPD Development Group. Preferred Reporting Items for Systematic Review and Meta-Analyses of individual participant data: the PRISMA-IPD Statement. JAMA. 2015;313:1657-65. [PMID: 25919529] doi:10.1001/jama.2015.3656 CrossrefMedlineGoogle Scholar3. Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted? Stat Med. 2002;21:1559-73. [PMID: 12111920] CrossrefMedlineGoogle Scholar4. Thompson SG, Higgins JP. Treating individuals 4: can meta-analysis help target interventions at individuals most likely to benefit? Lancet. 2005;365:341-6. [PMID: 15664231] CrossrefMedlineGoogle Scholar5. Lambert PC, Sutton AJ, Abrams KR, Jones DR. A comparison of summary patient-level covariates in meta-regression with individual patient data meta-analysis. J Clin Epidemiol. 2002;55:86-94. [PMID: 11781126] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Federico II University, Naples, and Ferrarotto Hospital, University of Catania, Catania, Italy.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-0060. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTranscatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement Giuseppe Gargiulo , Anna Sannino , Davide Capodanno , Marco Barbanti , Sergio Buccheri , Cinzia Perrino , Piera Capranzano , Ciro Indolfi , Bruno Trimarco , Corrado Tamburino , and Giovanni Esposito Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement Xinlin Zhang and Biao Xu Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement Marat Fudim , Gerald S. Bloomfield , and Zainab Samad Metrics Cited byTranscatheter Aortic Valve Implantation Futility Risk Model Development and Validation Among Treated Patients With Aortic Stenosis 18 April 2017Volume 166, Issue 8Page: 606KeywordsAortic valve replacementDisclosureForecastingHemodynamicsMortalityRandomized trials ePublished: 18 April 2017 Issue Published: 18 April 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...