tbuckley/cabot-search huggingface dataset:
Resistencias a fármacos antimicrobianos en aislamientos de Salmonella enterica procedentes de casos de salmonelosis humana en Europa, año 2000: resultados de la vigilancia internacional multicéntrica
Authors: E J Threlfall, I. S.T. Fisher, C Berghold, P Gerner-Smidt, H Tschäpe, M Cormican, L Luzzi, F Schneider, W J B Wannet, J Machado, G Edwards
Journal: Eurosurveillance (2003)

El sistema de vigilancia Enter-net recibio los resultados de las pruebas de sensibilidad a antimicrobianos de aislamientos de mas de 27.000 casos de salmonelosis humana registrados en diez paises europeos en el ano 2000. Casi un 40% de los aislamientos eran resistentes como minimo a un antimicrobiano, y un 18% era multirresistente. Fueron frecuentes las resistencias a ampicilina, estreptomicina, sulfonamidas y tetraciclinas, con mas de un 20% de aislamientos resistentes a al menos uno de estos antimicrobianos. La resistencia clinica al ciprofloxacino fue rara, con solo un 0,5% de los aislamientos resistentes a dicho antibiotico (MIC g1,0 mg/l). La resistencia al acido nalidixico unida a una menor sensibilidad al ciprofloxacino (MIC 0,25-1,0 mg/l) fue mas frecuente, con un 14% de los aislamientos con estas propiedades. La resistencia a cefalosporinas de tercera generacion fue poco frecuente, con solo un 0,6% de aislamientos resistentes a la cefotaxima. En todos los paises, las resistencias multiples fueron mas frecuentes en Salmonella enterica serotipo Typhimurium, con un 51% del total de aislamientos resistentes. En Inglaterra y Gales, la resistencia multiple tambien fue prevalente en S. Virchow y S. Hadar, mientras que en otros paises la multirresistencia fue frecuente en serotipos como S. Blockley.
Impact of Pre-Procedural Blood Pressure on Long-Term Outcomes Following Percutaneous Coronary Intervention
Authors: Josephine Warren, Shane Nanayakkara, Nick Andrianopoulos, Angela Brennan, Diem Dinh, Matias Yudi, David Clark, Andrew E. Ajani, Christopher M. Reid, Laura Selkrig, James Shaw, Chin Hiew, Melanie Freeman, David Kaye, Bronwyn A. Kingwell, Anthony M. Dart, Stephen J. Duffy, Chris Reid, Nick Andrianopoulos, Angela Brennan, Diem Dinh, Chris Reid, Andrew Ajani, Stephen Duffy, David Clark, Melanie Freeman, Chin Hiew, Nick Andrianopoulos, Ernesto Oqueli, Angela Brennan, S.J. Duffy, J.A. Shaw, A. Walton, A. Dart, A. Broughton, J. Federman, C. Keighley, C. Hengel, K.H. Peter, D. Stub, W. Chan, J. Warren, J. O’Brien, L. Selkrig, R. Huntington, D.J. Clark, O. Farouque, M. Horrigan, J. Johns, L. Oliver, J. Brennan, R. Chan, G. Proimos, T. Dortimer, B. Chan, V. Nadurata, R. Huq, D. Fernando, A. Al-Fiadh, M. Yudi, H. Sugumar, J. Ramchand, H. Han, S. Picardo, L. Brown, E. Oqueli, C. Hengel, A. Sharma, B. Zhu, N. Ryan, T. Harrison, G. New, L. Roberts, M. Freeman, M. Rowe, G. Proimos, Y. Cheong, C. Goods, D. Fernando, A. Teh, S. Parfrey, J. Ramzy, A. Koshy, P. Venkataraman, D. Flannery, C. Hiew, M. Sebastian, T. Yip, Michael Mok, C. Jaworski, A. Hutchinson, C. Cimenkaya, P. Ngu, B. Khialani, H. Salehi, M. Turner, J. Dyson, B. McDonald, D. Van Den Nouwelant, K. Halliburton, C. Reid, N. Andrianopoulos, A.L. Brennan, D. Dinh, B.P. Yan, A.E. Ajani, R. Warren, D. Eccleston, J. Lefkovits, R. Iyer, R. Gurvitch, W. Wilson, M. Brooks, S. Biswas, J. Yeoh
Journal: Journal of the American College of Cardiology (2019)
Comprehensive next-generation sequencing to identify targetable genetic alterations in advanced breast cancer patients
Authors: KienThiam Tan, Yen-Jung Yen, Chun-Jung Chen, Ren-Shiang Jou, Yi-Ting Yang, Yen-Ting Liu, Hua-Chien Chen, Shu-Jen Chen
Journal: Annals of Oncology (2017)
The birth of @ISNeducation
Authors: Tejas Desai, Arvind Conjeevaram, Omar Taco, Sanjeev Nair, Sivakumar Sridharan, Rolando Claure-Del Granado, Brendon Lange Neuen, Krishnam Raju Penmatsa, Gopal Basu, Florian Buchkremer, Ernesto Lopez-Almaraz, Fernanda Arce Amare, Xavier Parada, Miguel Cota Vargas, Zoran Paunic, Francesco Iannuzzella, Amit Langote, Hector Madariaga, Sonia Rodriguez Ramirez, Sibel Gokcay Bek, Carlos Orantes, Ananda Chapagain, Garima Aggarwal, Mayuri Trivedi, Sidharth Kumar Sethi
Journal: Kidney International (2017)
Trends and variation in prescribing of low-priority treatments identified by NHS England: a cross-sectional study and interactive data tool in English primary care
Authors: Alex J Walker, Helen J Curtis, Seb Bacon, Richard Croker, Ben Goldacre
Journal: Journal of the Royal Society of Medicine (2018)

Objectives NHS England recently announced a consultation seeking to discourage the use of treatments it considers to be low-value. We set out to produce an interactive data resource to show savings in each NHS general practice and to assess the current use of these treatments, their change in use over time, and the extent and reasons for variation in such prescribing. Design Cross-sectional analysis. Setting English primary care. Participants English general practices. Main outcome measures We determined the cost per 1000 patients for prescribing of each of 18 treatments identified by NHS England for each month from July 2012 to June 2017, and also aggregated over the most recent year to assess total cost and variation among practices. We used mixed effects linear regression to determine factors associated with cost of prescribing. Results Spend on low-value treatments was £153.5 m in the last year, across 5.8 m prescriptions (mean, £26 per prescription). Among individual treatments, liothyronine had the highest prescribing cost at £29.6 m, followed by trimipramine (£20.2 m). Over time, the overall total number of low-value prescriptions decreased, but the cost increased, although this varied greatly between treatments. Three treatment areas increased in cost and two increased in volume, all others reduced in cost and volume. Annual practice level spending varied widely (median, £2262 per thousand patients; interquartile range £1439 to £3298). Proportion of patients over 65 was strongly associated with low-value prescribing, as was Clinical Commissioning Group. Our interactive data tool was deployed to OpenPrescribing.net where monthly updated figures and graphs can be viewed. Conclusions Prescribing of low-value treatments is extensive but varies widely by treatment, geographic area and individual practice. Despite a fall in prescription numbers, the overall cost of prescribing for low-value items has risen. Prescribing behaviour is clustered by Clinical Commissioning Group, which may represent variation in the optimisation efficiency of medicines, or in some cases access inequality.
Genome-Wide DNA Methylation Profiling of Chronic Lymphocytic Leukemia Subsets Carrying Stereotyped B Cell Receptors
Authors: Richard Rosenquist, Larry Mansouri, Sujata Bhoi, Giancarlo Castellano, Lesley Ann Sutton, Nikos Papakonstantinou, Ana Queirós, Panagiotis Baliakas, Sara Ek, Venera Kuci Emruli, Karla Plevova, Stavroula Ntoufa, Zadie Davis, Emma Young, Hanna Goransson-Kultima, Anders Isaksson, Karin E Smedby, Gianluca Gaidano, Anton W Langerak, Frederic Davi, Davide Rossi, David Oscier, Sarka Pospisilova, Paolo Ghia, Elias Campo, Kostas Stamatopoulos, Inaki Martin Subero
Journal: Blood (2017)
Industry Influence in Dermatology Clinical Practice Guideline Development
Authors: Kenneth A. Katz
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
TCT-394 Impact of Creating a Telemedicine-Guided, Population-Based, ST Elevation Myocardial Infarction (STEMI) Network on Revascularization Strategy, Cost and Mortality
Authors: Sameer Mehta, Carlos Campos, Alex Au-Yeung, Adam Yoculan, Isaac Yepes, Roberto Botelho, Francisco Fernandez, Rodolfo Vega, Marco Alcocer-Gamba, Juan Carlos Perez Alva, Marco Perin, Rodolfo Cardoso, Cesar Dusilek, Mario Torres, Daniel Rodriguez
Journal: Journal of the American College of Cardiology (2017)
TCT-732 Relationship Between Stent Diameter, Platelet Reactivity, and Adverse Events After PCI: Analysis from the ADAPT-DES study
Authors: Bjorn Redfors, Philippe Généreux, Bernhard Witzenbichler, Ajay Jayant Kirtane, Thomas McAndrew, Bruce Brodie, Michael Rinaldi, Timothy Henry, David Cox, Ernest Mazzaferri, Ori Ben-Yehuda, Roxana Mehran, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Medical Scribes in an Academic Dermatology Practice
Authors: Vinod E. Nambudiri, Alice J. Watson, Elizabeth A. Buzney, Thomas S. Kupper, Mitchell H. Rubenstein, Fei-Shiuann Clarissa Yang
Journal: JAMA Dermatology (2017)

This study examines the implementation of a multipractice quality improvement pilot program evaluating medical scribe impact on dermatologist documentation time and physician satisfaction.
Large cell neuroendocrine carcinoma of the lung: chemotherapy regimen depends on how “large” your diagnostic criteria are
Authors: Giulio Rossi, Lucia Longo, Fausto Barbieri, Federica Bertolini, Paolo Spagnolo
Journal: European Respiratory Journal (2017)

We read with great interest the article by Derks et al . [1] on the efficacy of different chemotherapeutic regimens in a large series of 128 patients with stage IV large cell neuroendocrine carcinoma (LCNEC) of the lung. As outlined by the authors, in 2005, we dealt with the same dilemma when analysing 83 surgically resected LCNECs collected at two different institutions [2]. In our study, patients with metastatic disease treated either in an adjuvant setting or post-surgery with platinum/etoposide, a conventional regimen for small cell lung cancer (SCLC), showed a significant clinical benefit in terms of overall survival compared to patients treated with chemotherapeutic regimens used for non-small cell lung cancer (NSCLC). In contrast, Derks et al . [1] showed that patients with metastatic LCNEC receiving platinum/gemcitabine, a regimen commonly used in NSCLC, displayed a longer overall survival than those receiving SCLC-oriented chemotherapy. In our view, a number of reasons, discussed herein, may account for the apparent discrepancies between these and other studies [3]. In our study [2], LCNEC cases eventually represented less than one-quarter (83 (23.8%) out of 348) of all lung cancer cases identified based on morphological examination alone. In addition, although we applied strict diagnostic criteria, some cases required a consensus diagnosis among all three thoracic pathologists involved in the histological review, highlighting the difficulties encountered when making a diagnosis of LCNEC, even amongst expert pathologists [4]. In agreement with the last two World Health Organization (WHO) classifications of lung tumours [5] suggesting to limit/avoid the diagnosis of LCNEC on cytology/small biopsy, we included only surgically resected cases ( i.e . none of our original cases was in stage IV at the time of the diagnosis). Conversely, Derks et al . [1] and another recent study by Naidoo et al. [6] included only stage IV LCNEC cases diagnosed on biopsy. Diagnostic criteria influence the correct chemotherapy in LCNEC <http://ow.ly/MSPR30ePZNK>
TCT-460 Clinical Impact of Complete Coronary Revascularization by Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion in the First and Newer Drug-Eluting Stent Generation Era
Authors: Renato Valenti, Angela Migliorini, Andrea Bernardini, Maria Grazia De gregorio, Raffaele Martone, Maria Raffaella Aicale, Sofia Morini, Ruben Vergara, Martina Berteotti, Nazario Carrabba, David Antoniucci
Journal: Journal of the American College of Cardiology (2017)
Children still wait too long to get mental healthcare, finds review
Authors: Susan Mayor
Journal: BMJ (2017)

Children and young adults with mental health problems are not receiving the care they need because of long delays and fragmented services, a major review has found.1

“It’s been 20 years since the government commissioned its Every Child Matters initiative, and yet so many young people are still waiting too long for the right help at the right time,” said Bernadka Dubicka, chair of the child and adolescent faculty at the Royal College of Psychiatrists, commenting on the review’s findings.

She welcomed the Care Quality Commission’s review of mental health services for young people in England, which was commissioned by the government, and said that she hoped it would “result in urgent further investment in child mental health.”

The review analysed …
Abstract 17179: The Optimal Time of Percutaneous Coronary Intervention for Non-Culprit Vessel in Acute Myocardial Infarction Patients With Multivessel Disease
Authors: Inna Kim, Hae Chang Jeong, Ki Yuk Jang, Myung-Ho Jeong, Ju Han Kim, Young Joon Hong, Doo Sun Sim, Keun Ho Park, Ki Bae Seung, Youngkeun Ahn
Journal: Circulation (2013)

Objectives:  To determine the optimal time of percutaneous coronary intervention (PCI) for non-culprit vessel in acute myocardial infarction (AMI) patients with multivessel disease (MVD).   Background:  HORIZONS-AMI trial reported that staged PCI was related with better prognosis than single PCI. However, the optimal time of the second-stage PCI for non-culprit vessel is not clear.   Methods:  A total of 2,630 patients with AMI with MVD from 9 centers of 2 universities were registered in prospective COREA-AMI registry (COnvergent REgistry of catholic and chonnAm university for Acute MI) from Jan 2004 through Dec 2009. Out of these, we selected 1,397 patients treated by multivessel PCI. The eligible patients were divided by 5 groups according to the time interval from primary PCI to second stage PCI: group I (0 day, single PCI for culprit and non-culprit artery), group II (1-3 days after), group III (4-7 days after), group IV (8-14 days after), and group V (more than 15 days after). The endpoint was incidence of major adverse cardiac events (MACE) including cardiac death, re-MI, re-PCI during 1 year.   Results:  Study population was consisted with 753 patients with ST-segment elevation MI (STEMI) and 644 patients with non-STEMI. 982 patients were male, and their mean age was 64.2 years old. The composite of MACEs were significantly lowest in group III (p   Conclusions:  Performing the second stage PCI for non culprit vessel 4-7 days after primary PCI associated with lowest incidences of MACEs in AMI patient with MVD.
Situation actuelle de la poliomyélite en Europe face à l'objectif d'éradication
Authors: S Wassilak, G Oblapenko, S Dittmann
Journal: Eurosurveillance (1997)

En 1988, l'Assemblee Mondiale de la Sante a fixe l'objectif d'une eradication mondiale de la poliomyelite due au poliovirus sauvage pour l'an 2000. Les strategies de la campagne sont d'atteindre et de maintenir un niveau eleve de couverture de la vaccination de routine dans toute la population ; de permettre une vaccination supplementaire par le biais de campagnes de masse appelees Journees Nationales de Vaccination (JNV) pour les jeunes enfants sans tenir compte de leur statut vaccinal anterieur ; de realiser des operations de vaccination de proximite renforcees dans les groupes a haut risque ; et d'entreprendre une surveillance active des paralysies flasques aigues (PFA) pour detecter rapidement tous les cas possibles de poliomyelite et fournir des donnees virologiques permettant de confirmer l'absence de circulation du poliovirus sauvage. L'eradication de la poliomyelite a ete certifiee dans la Region des Ameriques de l'OMS en 1994. Ce rapport presente la situation actuelle pour atteindre ce but dans la region Europe de l'OMS (51 etats membres comprenant les Nouveaux Etats Independants (NEI) de l'ex-Union Sovietique, la Turquie et Israel).
Abstract 19225: Sustained Release of VEGF via PLGA Nanoparticles Improves Vascularization in vitro and in vivo
Authors: Yasin Oduk, Ramaswamy Kannappan, Wuqiang Zhu, Jianyi Zhang
Journal: Circulation (2016)

Introduction: Vascular endothelial growth factor (VEGF) has a leading role in the angiogenic process and is a promising agent to promote revascularization in the infarcted heart. Several clinical t...
TCT-118 Leaflet Thrombosis Following Transcatheter Aortic Valve-in-Valve Implantation: A Comparative Modeling Study of SAPIEN 3 and CoreValve in PERIMOUNT Magna Surgical Bioprosthesis
Authors: Koohyar Vahidkhah, Mostafa Abbasi, Mohammad Barakat, Danny Dvir, Ali Azadani
Journal: Journal of the American College of Cardiology (2017)
Exaggerated report of benefits in a flawed long term statin treatment study
Authors: David Diamond, Malcolm Kendrick, Luca Mascitelli
Journal: BMJ (2017)

The BMJ reports on the findings of a study on long term (20 year) treatment with a statin in the WOSCOPS trial by Vallejo-Vaz et al.12 The news article and publication report that, in this primary prevention trial, pravastatin reduced deaths from heart disease by 28% in men with high levels of LDL cholesterol. But 28% …
<i>In vivo</i> Zika virus detection in human skin
Authors: N. Cordel, V. Hébert, A. Vega Rua, C. Herrmann-Storck
Journal: British Journal of Dermatology (2017)

Zika virus (ZIKAV) a Flavivirus mainly transmitted by Aedes aegypti and Aedes albopictus mosquitoes has been responsible for an extensive epidemic affecting people in more than 56 countries since its emergence in Brazil in 2015 (1). Evidence of the neuroinvasiveness and the tropism of ZIKAV for placenta trophoblasts has turned an infection, originally known for its mildness, into a major world public health concern due to the severity and dissemination of associated disorders (i.e.: congenital Zika syndrome and Guillain Barre syndrome) (2). Despite a commonly short viremia of low intensity the spread of ZIKAV infection is primarily due to vectorial transmission rather than to vertical or sexual transmission which have recently been evidenced (3-5).

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Development and psychometric validation of a patient-reported outcome measure to assess fears in rheumatoid arthritis and axial spondyloarthritis: the Fear Assessment in Inflammatory Rheumatic diseases (FAIR) questionnaire
Authors: Laure Gossec, Pierre Chauvin, Alain Saraux, Christophe Hudry, Gabrielle Cukierman, Thibault de Chalus, Caroline Dreuillet, Vincent Saulot, Sabine Tong, Françoise Russo-Marie, Jean-Michel Joubert, Francis Berenbaum
Journal: Annals of the Rheumatic Diseases (2017)

Objectives To develop and validate an outcome measure for assessing fears in patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA). Methods Fears were identified in a qualitative study, and reformulated as assertions with which participants could rate their agreement (on a 0–10 numeric rating scale). A cross-sectional validation study was performed including patients diagnosed with RA or axSpA. Redundant items (correlation &gt;0.65) were excluded. Internal consistency (Cronbach’s α) and factorial structure (principal component analysis) were assessed. Patients were classified into fear levels (cluster analysis). Associations between patient variables and fear levels were evaluated using multiple logistic regression. Results 672 patients were included in the validation study (432 RA, 240 axSpA); most had moderate disease activity and were prescribed biologics. The final questionnaire included 10 questions with high internal consistency (α: 0.89) and a single dimension. Mean scores (±SD) were 51.2 (±25.4) in RA and 60.5 (±22.9) in axSpA. Groups of patients with high (17.2%), moderate (41.1%) and low (41.7%) fear scores were identified. High fear scores were associated with high Arthritis Helplessness Index scores (OR 6.85, 95% CI (3.95 to 11.87)); high Hospital Anxiety and Depression Scale anxiety (OR 5.80, 95% CI (1.19 to 4.22)) and depression (OR 2.37, 95% CI (1.29 to 4.37)) scores; low education level (OR 3.48, 95% CI (1.37 to 8.83)); and high perceived disease activity (OR 2.36, 95% CI (1.10 to 5.04)). Conclusions Overall, 17.2% of patients had high fear scores, although disease was often well controlled. High fear scores were associated with psychological distress. This questionnaire could be useful both in routine practice and clinical trials.
TCT-59 Prevalence, predictors and outcomes of bleeding complications in peripheral vascular interventions for lower extremities: Insights from the NCDR PVI registry
Authors: Bhaskar Bhardwaj, John Spertus, Kevin Kennedy, Schuyler Jones, David Safley, Thomas Tsai, Herbert Aronow, Amit Vora, Yashashwi Pokharel, Robert R. Attaran, Dmitriy Feldman, Adam Salisbury
Journal: Journal of the American College of Cardiology (2017)
Reply to Nelson Martinez Merizalde Balarezo, Mark Monroe Rivera, and Romina A. Tejada's Letter to the Editor re: Maud Rijnders, Ronald de Wit, Joost L. Boormans, Martijn P.J. Lolkema, Astrid A.M. van der Veldt. Systematic Review of Immune Checkpoint Inhibition in Urological Cancers. Eur Urol. 2017;72:411–23. Beyond the Survival Rate, Health-related Quality of Life is Important
Authors: Maud Rijnders, Ronald de Wit, Joost L. Boormans, Martijn P.J. Lolkema, Astrid A.M. van der Veldt
Journal: European Urology (2017)
Food protein‐induced enterocolitis syndrome by fish: Not necessarily a restricted diet
Authors: S. Infante, G. Marco‐Martín, M. Sánchez‐Domínguez, A. Rodríguez‐Fernández, V. Fuentes‐Aparicio, A. Alvarez‐Perea, P. Cabrera‐Freitag, C. Morales‐Cabeza, J. M. Zubeldia, L. Zapatero
Journal: Allergy (2017)

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity usually due to cow's milk or soy. Recent researches show that fish is 1 of the most important triggers of FPIES in the Mediterranean countries. Due to the risk of multiple-food FPIES, avoiding foods in the same category or that often occur together may be reasonable. The aim of this study was to evaluate the evolution and follow-up of FPIES related to fish over a period of 20 years. We describe the clinical features of our population, discuss different approaches to oral food challenges, and analyze the possibility of introducing the culprit fish or other nonrelated fish to avoid unnecessary restricted diets.
David Oliver: Challenging the victim narrative about NHS doctors
Authors: David Oliver
Journal: BMJ (2017)

In July, I posted some tweets arguing that doctors still have high professional status, public respect, secure and relatively well paid careers, and a great deal of hard power and soft influence. I said that doctors shouldn’t describe themselves using the language of hapless, impotent victims of the state.

Plenty of doctors agreed with me, often those who had taken on difficult service leadership roles with all of the challenges those entail. And plenty disagreed vehemently.

Years of below-inflation pay rises, the mistreatment of whistleblowers and the inefficacy of mechanisms to protect them, and the government’s indefensible, demoralising attitude to junior doctors during last year’s contract stand-off were all cited as evidence of our disempowerment. They certainly contribute to doctors’ sense of being less influential than we once were—or were expecting …