tbuckley/cabot-search huggingface dataset:
PS04.08 A Phase I Trial to Evaluate Concurrent or Sequential Ipilimumab, Nivolumab, and Stereotactic Body Radiotherapy in Stage IV NSCLC
Authors: M.J. Jelinek, J.M. Melotek, E.E. Vokes, R.R. Weichselbaum, S.J. Chmura, J.D. Patel
Journal: Journal of Thoracic Oncology (2017)
Pasteurized Milk as a Vehicle of Infection in an Outbreak of Listeriosis
Authors: David W. Fleming, Stephen L. Cochi, Kristine L. MacDonald, Jack Brondum, Peggy S. Hayes, Brian D. Plikaytis, Marion B. Holmes, A. Audurier, Claire V. Broome, Arthur L. Reingold
Journal: New England Journal of Medicine (1985)

Between June 30th and August 30th, 1983, 49 patients in Massachusetts acquired listeriosis. Seven cases occurred in fetuses or infants and 42 in immunosuppressed adults; 14 patients (29 per cent) died. Of 40 Listeria monocytogenes isolates available for testing, 32 were serotype 4b. Two case-control studies, one matching for neighborhood of residence and the other for underlying disease, revealed that the illness was strongly associated with drinking a specific brand of pasteurized whole or 2 per cent milk (odds ratio = 9, P less than 0.01 for the neighborhood-matched study; odds ratio = 11.5, P less than 0.001 for the illness-matched study). The association with milk was further substantiated by four additional analyses that suggested the presence of a dose-response effect, demonstrated a protective effect of skim milk, associated cases with the same product in an independent study in another state, and linked a specific phage type with the disease associated with milk. The milk associated with disease came from a group of farms on which listeriosis in dairy cows was known to have occurred at the time of the outbreak. Multiple serotypes of L. monocytogenes were isolated from raw milk obtained from these farms after the outbreak. At the plant where the milk was processed, inspections revealed no evidence of improper pasteurization. These results support the hypothesis that human listeriosis can be a foodborne disease and raise questions about the ability of pasteurization to eradicate a large inoculum of L. monocytogenes from contaminated raw milk.
Imaging pathophysiological changes in the lungs in IPF with xenon magnetic resonance imaging
Authors: Jim M Wild
Journal: Thorax (2017)

Although forced vital capacity is validated for the assessment of idiopathic pulmonary fibrosis (IPF) progression and prediction of mortality, the need for tests that are more sensitive to pathophysiological change in the lungs in IPF is well recognised for earlier diagnosis, longitudinal assessment and for better markers of therapy and prognosis.1 

Imaging in IPF in clinical radiological practice currently resides with structural computed tomography. The structural changes seen in IPF on computed tomography are regionally heterogeneous and represent different aspects of the pathology and lung disease evolution.2 Computed tomography is now being used more quantitatively with image segmentation and texture analysis to classify the different structural changes. These algorithms show prognostic promise,3 but it remains to be seen how sensitive they are to disease progression. There is a possibility that manifestation of structural changes on computed tomography is too late …
The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis
Authors: Puneet Puri, Suthat Liangpunsakul, Jeffrey E. Christensen, Vijay H. Shah, Patrick S. Kamath, Gregory J. Gores, Susan Walker, Megan Comerford, Barry Katz, Andrew Borst, Qigui Yu, Divya P. Kumar, Faridoddin Mirshahi, Svetlana Radaeva, Naga P. Chalasani, David W. Crabb, Arun J. Sanyal
Journal: Hepatology (2017)

Intestinal dysbiosis is implicated in alcoholic hepatitis (AH). However, changes in the circulating microbiome, its association with the presence and severity of AH, and its functional relevance in AH is unknown. Qualitative and quantitative assessment of changes in the circulating microbiome were performed by sequencing bacterial DNA in subjects with moderate AH (MAH) (n = 18) or severe AH (SAH) (n = 19). These data were compared with heavy drinking controls (HDCs) without obvious liver disease (n = 19) and non-alcohol-consuming controls (NACs, n = 20). The data were related to endotoxin levels and markers of monocyte activation. Linear discriminant analysis effect size (LEfSe) analysis, inferred metagenomics, and predictive functional analysis using PICRUSt were performed. There was a significant increase in 16S copies/ng DNA both in MAH (P < 0.01) and SAH (P < 0.001) subjects. Compared with NACs, the relative abundance of phylum Bacteroidetes was significantly decreased in HDCs, MAH, and SAH (P < 0.001). In contrast, all alcohol-consuming groups had enrichment with Fusobacteria; this was greatest for HDCs and decreased progressively in MAH and SAH. Subjects with SAH had significantly higher endotoxemia (P = 0.01). Compared with alcohol-consuming groups, predictive functional metagenomics indicated an enrichment of bacteria with genes related to methanogenesis and denitrification. Furthermore, both HDCs and SAH showed activation of a type III secretion system that has been linked to gram-negative bacterial virulence. Metagenomics in SAH versus NACs predicted increased isoprenoid synthesis via mevalonate and anthranilate degradation, known modulators of gram-positive bacterial growth and biofilm production, respectively.
A combination of soy isoflavone diet and radiation synergistically inhibits the growth of human prostate cancer xenografts
Authors: Kathleen Shiverick, Wengang Cao, Theresa Medrano, Charles Rosser
Journal: Cancer Research (2008)

429   Studies have reported that soy isoflavones inhibit growth in a number of carcinoma cell lines and may enhance radiotherapy. Our study investigated the interaction of a soy isoflavone diet (ISF) and radiation on PC-3 human prostate xenograft tumors, which are androgen-insensitive and do not express p53 or PTEN tumor suppressor genes.  Methods: Male nude mice on a soy-free control diet were injected with PC-3-prostate cancer cells into the hind flank. On day 5, half the mice were placed on a diet containing 0.5% soy isoflavone concentrate (ISF). On day 9, half the mice from each diet group were randomly irradiated to 2 Gy (XRT). Tumor sizes were monitored biweekly. Resected tumors were fixed in formalin and paraffin-embedded. Immunohistochemical staining was performed using antibodies against p21 CIP1 ,  Akt, phosphorylated-Akt (pAKT), VEGF, CD34 and PCNA. Results: Both the soy ISF diet and radiation treatment were well tolerated and significantly inhibited xenograft tumor growth. Compared with either treatment alone, the combination of soy ISF and radiation (2 Gy) further inhibited xenograft tumor growth. At 39 days, median tumor size was 659 mm 3  in soy-free controls, 283 mm 3  in mice treated with radiation (p=0.002), 384 mm 3  in mice on the ISF diet (p=0.018), and 201 mm 3  in mice treated with the combination (p  =0.0005). Immunohistochemical staining showed that radiation markedly decreased tumor cell density and the expression of nuclear PCNA and cytoplasmic VEGF. In contrast, the predominant effects of the ISF diet were markedly decreased staining for PCNA and phos-Akt, a major prosurvival mediator overexpressed in PC-3 tumor cells. The ISF diet further inhibited tumor cell proliferation with increased levels of p21 CIP1 , a major inhibitor of cyclin-dependent kinases and cell cycle progression. An anti-angiogenic effect of ISF was also seen with decreases in VEGF and microvessel CD34 staining in tumors. Combination ISF and XRT treatment further supressed cellular proliferation and tumor-induced neovascularity. Thus, inhibition of xenograft tumor growth by radiation and an ISF diet, respectively, involved distinct mechanisms within the tumor microenvironment. Conclusions:  Together, these findings indicate that the combination of soy ISF and radiation strongly inhibited the growth of human prostate tumors which is mediated by the inhibition of angiogenesis and cellular proliferation. The interactive effect of soy with radiation may involve a radiosensitizing effect of ISF as well as growth inhibition of cells that survive post-irradiation. (Supported by grants from NIH CA102386 and the Maren Foundation)
Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association
Authors: Mercedes R. Carnethon, Jia Pu, George Howard, Michelle A. Albert, Cheryl A.M. Anderson, Alain G. Bertoni, Mahasin S. Mujahid, Latha Palaniappan, Herman A. Taylor, Monte Willis, Clyde W. Yancy
Journal: Circulation (2017)

Population-wide reductions in cardiovascular disease incidence and mortality have not been shared equally by African Americans. The burden of cardiovascular disease in the African American community remains high and is a primary cause of disparities in life expectancy between African Americans and whites. The objectives of the present scientific statement are to describe cardiovascular health in African Americans and to highlight unique considerations for disease prevention and management.The primary sources of information were identified with PubMed/Medline and online sources from the Centers for Disease Control and Prevention.The higher prevalence of traditional cardiovascular risk factors (eg, hypertension, diabetes mellitus, obesity, and atherosclerotic cardiovascular risk) underlies the relatively earlier age of onset of cardiovascular diseases among African Americans. Hypertension in particular is highly prevalent among African Americans and contributes directly to the notable disparities in stroke, heart failure, and peripheral artery disease among African Americans. Despite the availability of effective pharmacotherapies and indications for some tailored pharmacotherapies for African Americans (eg, heart failure medications), disease management is less effective among African Americans, yielding higher mortality. Explanations for these persistent disparities in cardiovascular disease are multifactorial and span from the individual level to the social environment.The strategies needed to promote equity in the cardiovascular health of African Americans require input from a broad set of stakeholders, including clinicians and researchers from across multiple disciplines.
Rheumatoid arthritis, γδ T cells and bisphosphonates
Authors: Maurizio Rossini, Giovanni Adami, Ombretta Viapiana, Luca Idolazzi, Angelo Fassio, Alessandro Giollo, Cristian Caimmi, Giovanni Orsolini, Davide Gatti
Journal: Annals of the Rheumatic Diseases (2017)

We read with great interest the results of the study of Mo et al .1 The authors suggest that γδ T cells are involved in the pathogenesis of rheumatoid arthritis (RA). The study showed a significant reduction, in patients with RA, of peripheral total γδ T cells (particularly Vδ2 T cells, the major population of peripheral blood γδ T cells). The percentage of peripheral Vδ2 T cells of RA was negatively correlated with the levels of inflammatory markers, including C-reactive protein, erythrocyte sedimentation rate as well as the Disease Activity Score in 28 joints. The peripheral reduction of Vδ2 …
Impressive response to immunotherapy in a metastatic gastric cancer patient: could somatic copy number alterations help patient selection?
Authors: Gustavo dos Santos Fernandes, Daniel da Motta Girardi, Luiza Dib Batista Bugiato Faria, João Paulo Giacomini Bernardes, Renata de Almeida Coudry
Journal: Journal for ImmunoTherapy of Cancer (2017)

<h3>Background</h3> Metastatic gastric cancer (GC) is an incurable and aggressive disease with a poor prognosis. Immunotherapy is an attractive approach for treating patients with cancer, and studies using immunotherapy have shown promising results in melanoma, kidney and non-small cell lung cancers, among others. <h3>Case presentation</h3> We present a case of a 50-year-old woman with metastatic GC whose cancer had progressed after first-line chemotherapy and who received pembrolizumab as an experimental treatment. Molecular analyses showed that her tumor was negative for PD-L1 expression, contained microsatellite stability and several focal somatic copy number alterations. The patient experienced an almost complete response after eleven cycles of treatment. Her symptoms related to the disease disappeared, and the medication was well tolerated. <h3>Conclusions</h3> Despite reports of promising responses in some patients, immunotherapy is not suitable for all patients; therefore, we explored the molecular characteristics that could explain the exceptional response and clinical benefits observed in our patient.
Abstract 15686: Electron Tomography and Live Tissue Confocal Imaging Reveal Contrasting Ultrastructural Abnormalities in Calcium Release Units of CPVT Mouse Models Due to Calsequestrin and Ryanodine Receptor Mutations
Authors: Ramesh Iyer, Manuela Lavorato, Clara Franzini-Armstrong
Journal: Circulation (2016)

Introduction: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a disease characterized by life-threatening ventricular arrhythmias (VA). Major CPVT mutations involve two proteins of ...
Long-term Effect of Biomineralized Insulin Nanoparticles on Type 2 Diabetes Treatment
Authors: Yun Xiao, Xiaoyu Wang, Ben Wang, Xueyao Liu, Xurong Xu, Ruikang Tang
Journal: Theranostics (2017)

Intracellular insulin may exhibit a long-term effect in regulating protein synthesis, DNA synthesis, and gene transcription.However, the intracellular delivery of insulin is a great challenge.Here, we describe how a simple biomineralization modification of insulin can transport it into intact cells on a large scale, leading to a long-term therapeutic effect on diabetes mellitus.Using insulin-resistant HepG2 cell and diabetic KKAy mice as models, in vitro and in vivo assessments have demonstrated that biomineralized insulin nanoparticles can trigger glucose metabolism, and this improvement extends after the treatment.The potential exists to improve the current treatment of type 2 diabetes mellitus through biomineralized modifications of insulin.This study provides a new paradigm of biomimetic nanotechnology for biomedical applications.
Recycling drug screen repurposes hydroxyurea as a sensitizer of glioblastomas to temozolomide targeting de novo DNA synthesis, irrespective of molecular subtype
Authors: Jian Teng, Seyedali Hejazi, Lotte Hiddingh, Litia Carvalho, Mark C de Gooijer, Hiroaki Wakimoto, Marco Barazas, Marie Tannous, Andrew S Chi, David P Noske, Pieter Wesseling, Thomas Wurdinger, Tracy T Batchelor, Bakhos A Tannous
Journal: Neuro-Oncology (2017)

Abstract Background Glioblastoma (GBM) is the most common and most aggressive primary malignant brain tumor. Standard-of-care treatment involves maximal surgical resection of the tumor followed by radiation and chemotherapy (temozolomide [TMZ]). The 5-year survival rate of patients with GBM is &amp;lt;10%, a colossal failure that has been partially attributed to intrinsic and/or acquired resistance to TMZ through O6-methylguanine DNA methyltransferase (MGMT) promoter methylation status in the tumor. Methods A drug screening aimed at evaluating the potential recycling and repurposing of known drugs was conducted in TMZ-resistant GBM cell lines and primary cultures of newly diagnosed GBM with different MGMT promoter methylation status, phenotypic/genotypic background and subtype, and validated with sphere formation, cell migration assays, and quantitative invasive orthotopic in vivo models. Results We identified hydroxyurea (HU) to synergize with TMZ in GBM cells in culture and in vivo, irrespective of MGMT promoter methylation status, subtype, and/or stemness. HU acts specifically on the S-phase of the cell cycle by inhibiting the M2 unit of enzyme ribonucleotide reductase. Knockdown of this enzyme using RNA interference and other known chemical inhibitors exerted a similar effect to HU in combination with TMZ both in culture and in vivo. Conclusions We demonstrate preclinical efficacy of repurposing hydroxyurea in combination with TMZ for adjuvant GBM therapy. This combination benefit is of direct clinical interest given the extensive use of TMZ and the associated problems with TMZ-related resistance and treatment failure.
Novel curcumin mimics: Potential anticancer drugs against human glioblastoma multiforme
Authors: Yongchel Ahn, Cheon-Soo Park, HyukJai Jang, JiHwan Lee, Mikyong Byun, Byung-Gon Park, Woon-Seob Shin, Yoon-Sun Park, Seokjoon Lee, Daeho Kwon
Journal: Annals of Oncology (2017)
TCT-840 Impact of Insulin-treated Diabetes Mellitus on Clinical Outcomes of Patients After Stent Implantation for Left Main Coronary Artery: a Report from the Multicenter AOI LMCA Stenting Registry
Authors: Kazuki Matsushita, Masanobu Ohya, Kazushige Kadota, Mamoru Toyofuku, Takeshi Morimoto, Hirooki Higami, Yasushi Fuku, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2017)
Do admission glucose levels aid in predicting mortality associated with community-acquired pneumonia?
Authors: Douwe F. Postma, Cornelis H. van Werkhoven, Darren P.R. Troeman, Sanjay U.C. Sankatsing, Jan Jelrik Oosterheert, Marc J.M. Bonten
Journal: European Respiratory Journal (2017)

Diabetes mellitus increases the risk of and mortality associated with community-acquired pneumonia (CAP) [1]. Hyperglycaemia negatively impacts both the innate and adaptive immune response, which could lead to decreased bacterial clearance and increased mortality from infection [2]. This can be extended to non-diabetic patients as well: hyperglycaemia on admission is an independent risk factor for higher complication rates, longer length of stay, and higher mortality in diabetics and non-diabetics with CAP [3–6]. Hypoglycaemia on admission has also been associated with an independent increased risk of mortality in patients with CAP [7, 8]. Currently, two severity scoring systems are widely used for predicting CAP mortality: the pneumonia severity index (PSI) and CURB-65 score (confusion, urea >7 mmol·L−1, respiratory rate ≥30 breaths·min−1, blood pressure <90 mmHg (systolic) or ≤60 mmHg (diastolic), age ≥65 years) [5, 9]. Admission glucose levels (AGL) are part of the PSI, as a categorical variable for hyperglycaemia, but not of CURB-65. We, therefore, investigated whether AGL contributes to these severity scores when both hypo- and hyperglycaemic states are appropriately modelled. Admission glucose levels do not improve discrimination of current severity scores in community-acquired pneumonia <http://ow.ly/Dyrz30f7Bwi> We would like to thank the members of the CAP-START study group for securing the conduct of the study in all participating hospitals. Additional thanks to Tim P. Morris, MRC Clinical Trials Unit at University College London, for his guidance on applying fractional polynomial estimation and selection in a multiple imputation context.
TCT-15 A First-in-Man Study of the Bioheart Sirolimus-Eluting Bioresorbable Vascular Scaffold in Patients with Coronary Artery Disease: Six-Month Clinical and Imaging Outcomes
Authors: Yongjian Wu, Zhongwei Sun, Lijian Gao, Shubin Qiao, Haibo Liu, Fenghuan Hu, Changdong Guan, Bo Xu
Journal: Journal of the American College of Cardiology (2017)
TCT-4 Prognostic Impact of Non-Culprit Chronic Total Occlusions in Infarct-Related Cardiogenic Shock: Results of the Randomized IABP-SHOCK II Trial
Authors: Mohammed Saad, Georg Fuernau, Steffen Desch, Ingo Eitel, Suzanne de Waha, Janine Pöss, Holger Thiele
Journal: Journal of the American College of Cardiology (2017)
Azacytidine is effective in the therapy related myelodysplastic syndrome
Authors: Hirofumi Yamauchi, Masahiro Yokoyama, Yuko Mishima, Noriko Nishimura, Kyoko Ueda, Yoshiharu Kusano, Norihito Inoue, Anna Takahashi, Yasuhito Terui, Kiyohiko Hatake
Journal: Annals of Oncology (2017)
Efficacy and safety of AAV2 gene therapy in children with aromatic L-amino acid decarboxylase deficiency: an open-label, phase 1/2 trial
Authors: Yin-Hsiu Chien, Ni-Chung Lee, Sheng-Hong Tseng, Chun-Hwei Tai, Shin-ichi Muramatsu, Barry J Byrne, Wuh-Liang Hwu
Journal: The Lancet Child & Adolescent Health (2017)
Molecular mechanism of Gd@C 82 (OH) 22 increasing collagen expression: Implication for encaging tumor
Authors: Jing Liu, Seung-gu Kang, Peng Wang, Yue Wang, Xiaonan Lv, Ying Liu, Fei Wang, Zonglin Gu, Zaixing Yang, Jeffrey K. Weber, Ning Tao, Zhihai Qin, Qing Miao, Chunying Chen, Ruhong Zhou, Yuliang Zhao
Journal: Biomaterials (2017)
Incidence des marqueurs viraux et évaluation des risques dans la population des donneurs de sang en Suisse de 1996 à 2003
Authors: C Niederhauser, P Schneider, M Fopp, A Ruefer, G Lévy
Journal: Eurosurveillance (2005)

Parmi les risques connus lies a la transfusion sanguine, la transmission des virus pathogenes est consideree comme l’un des plus serieux et une serie de mesures ont ete mises en place avec succes au cours des deux dernieres decennies pour le reduire. Aujourd’hui, le risque de transmission d’infections virales par les produits sanguins est tres faible dans les pays developpes. L’etude presentee analyse, entre 1996 et 2003, l’incidence du VIH, du virus de l’hepatite B (VHB) et du virus de l’hepatite C (VHC) chez 99% des donneurs de sang connus des services de transfusion sanguine de la Croix-Rouge Suisse, ainsi que l’estimation du risque de ces marqueurs viraux. Au cours de cette periode, le taux d‘incidence du VHC n’a cesse de diminuer, alors que le taux d’incidence du VIH et du VHB n’a pas diminue de maniere significative. De 2001 a 2003, derniere periode calculee, le risque residuel etait estime a 1 pour 1 900 000 pour le VIH, 1 pour 2 200 0000 pour le VHC, et 1 pour 115 000 pour le VHB. Ces resultats concordent avec les etudes internationales montrant, entre 1996 et 2003, un risque residuel estime pour le VHB plus eleve que pour le VHC et le HIV.
TCT-251 Abnormal glucose metabolism and adverse event rates 12 months after treatment with contemporary drug-eluting stents: Insights from the BIO-RESORT Silent Diabetes study
Authors: Marlies Kok, Clemens von Birgelen, Paolo Zocca, Marc Hartmann, K. Gert van Houwelingen, Martin Stoel, Frits de Man, J.Hans Louwerenburg, Marije Lowik, Gert Kant, Cees Doelman, Gerard C.M. Linssen, Liefke van der Heijden, Carine J.M. Doggen, Kenneth Tandjung
Journal: Journal of the American College of Cardiology (2017)
TCT-401 Associations Between Baseline Atrial Fibrillation And Risk Of 1-Year Outcomes After Transcatheter Aortic Valve Replacement: Results From The WIN-TAVI Registry
Authors: Alaide Chieffo, Anna Sonia Petronio, Julinda Mehilli, Jaya Chandrasekhar, Samantha Sartori, Thierry Lefevre, Piera Capranzano, Didier Tchetche, Alessandro Iadanza, Gennaro Sardella, Nicolas Van Mieghem, Nicolas Dumonteil, Chiara Fraccaro, Daniela Trabattoni, Ghada Mikhail, Samin Sharma, Maria-Cruz Ferrer Gracia, Peter Kievit, Usman Baber, Clayton Snyder, Madhav Sharma, Marie-Claude Morice, Roxana Mehran
Journal: Journal of the American College of Cardiology (2017)
Abstract 14517: Adaptive Cluster Analysis of Individual Patient Level Adherence From Electronically Monitored Medication Adherence Predicts Hospitalization Rates in Heart Failure Patients
Authors: Jia-rong Wu, George Knafl, Debra K Moser
Journal: Circulation (2016)

Background: Electronic monitoring (EM) of medication use is the gold standard measure of medication adherence with the capacity to explore patient’s patterns of medication taking over time. However...