tbuckley/cabot-search huggingface dataset:
Occurrence of hepatocellular carcinoma in HIV/HCV co-infected patients treated with direct-acting antivirals
Authors: Hamid Hasson, Marco Merli, Emanuela Messina, Sherrie Bhoori, Stefania Salpietro, Giulia Morsica, Enrico Regalia, Sabrina Bagaglio, Adriano Lazzarin, Caterina Uberti-Foppa, Vincenzo Mazzaferro
Journal: Journal of Hepatology (2017)
Abstract 150: Determining Changes in Contractility, Myofilament Expression and Myofilament Sensitivity in the Developing Human Ventricle
Authors: Brian H Crawford, Talib Saafir, Gitanjali Baroi, Ming Shen, Ronald Joyner, Guoliang Ding, Mary Wagner
Journal: Circulation Research (2012)

As pediatric cardiac surgery is increasingly performed in the first year of life, the need for understanding contractility regulation becomes increasingly important. We examined contractility and myofilament changes in ventricular biopsies removed as part of the surgical correction of congenital heart defects from newborns (NB) (hypoplastic left heart syndrome, &lt; 1 wk old) and infants (IF) (tetralogy of Fallot, 3-12 mo old). Sarcomere shortening and calcium (Ca) transients were measured in isolated ventricular cells stimulated at 0.5 and 1 Hz. Increasing pacing frequency caused a significant increase in sarcomere shortening (p&lt; 0.05)in only the IF, but the Ca transient amplitude was relatively unchanged in both groups. Consistent with work in the developing rat heart, we found an isoform switch with increasing developmental age in myofilament proteins, troponin T (TnT) and troponin I (TnI). Western blot analysis revealed that total TnI (the sum of cardiac TnI (cTnI) and slow skeletal TnI (ssTnI)) was not significantly different between the two age groups. However, when comparing only the cTnI isoforms, we found that the NB had a significantly lower levels compared to the IF (11556±789 a.u. vs. 21770±1700 a.u., p&lt;0.001). Analysis of the RT-PCR revealed nearly significant lower levels of TnT isoform 1 in the IF group than the NB group (p=0.078), no significant difference in the levels of TnT isoform 2 (p= 0.536), and significantly higher levels of TnT isoform 3 in the IF group than the NB group (p= 0.039). We also observed developmental changes in myofilament sensitivity to calcium as assessed by measuring the gradient of the fura-2 cell length trajectory on phase-plane diagrams during the late relaxation of the twitch contraction. These results collectively suggest that contractility and myofilament changes, or the lack of changes, may serve as targets for clarifying elements associated with cardiac dysfunction in the developing human ventricle.
Bevacizumab and paclitaxel–carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial
Authors: Robert L Coleman, Mark F Brady, Thomas J Herzog, Paul Sabbatini, Deborah K Armstrong, Joan L Walker, Byoung-Gie Kim, Keiichi Fujiwara, Krishnansu S Tewari, David M O'Malley, Susan A Davidson, Stephen C Rubin, Paul DiSilvestro, Karen Basen-Engquist, Helen Huang, John K Chan, Nick M Spirtos, Raheela Ashfaq, Robert S Mannel
Journal: The Lancet Oncology (2017)
Characteristics of Fentanyl Overdose — Massachusetts, 2014–2016
Authors: Nicholas J. Somerville, Julie O’Donnell, R. Matthew Gladden, Jon E. Zibbell, Traci C. Green, Morgan Younkin, Sarah Ruiz, Hermik Babakhanlou-Chase, Miranda Chan, Barry P. Callis, Janet Kuramoto-Crawford, Henry M. Nields, Alexander Y. Walley
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Opioid overdose deaths in Massachusetts increased 150% from 2012 to 2015 (1). The proportion of opioid overdose deaths in the state involving fentanyl, a synthetic, short-acting opioid with 50-100 times the potency of morphine, increased from 32% during 2013-2014 to 74% in the first half of 2016 (1-3). In April 2015, the Drug Enforcement Agency (DEA) and CDC reported an increase in law enforcement fentanyl seizures in Massachusetts, much of which was believed to be illicitly manufactured fentanyl (IMF) (4). To guide overdose prevention and response activities, in April 2016, the Massachusetts Department of Public Health and the Office of the Chief Medical Examiner collaborated with CDC to investigate the characteristics of fentanyl overdose in three Massachusetts counties with high opioid overdose death rates. In these counties, medical examiner charts of opioid overdose decedents who died during October 1, 2014-March 31, 2015 were reviewed, and during April 2016, interviews were conducted with persons who used illicit opioids and witnessed or experienced an opioid overdose. Approximately two thirds of opioid overdose decedents tested positive for fentanyl on postmortem toxicology. Evidence for rapid progression of fentanyl overdose was common among both fatal and nonfatal overdoses. A majority of interview respondents reported successfully using multiple doses of naloxone, the antidote to opioid overdose, to reverse suspected fentanyl overdoses. Expanding and enhancing existing opioid overdose education and prevention programs to include fentanyl-specific messaging and practices could help public health authorities mitigate adverse effects associated with overdoses, especially in communities affected by IMF.
Independent board needed to promote research integrity, US panel says
Authors: Michael McCarthy
Journal: BMJ (2017)

A new US report calls for the creation of an independent advisory board to help scientists, scientific institutions, journals, and other participants tackle research misconduct and reduce questionable practices, which, while they might not represent misconduct, harm research enterprise.1

The report was prepared by a committee convened by the US National Academies of Sciences, Engineering, and Medicine to deal with growing concerns that, despite efforts to promote integrity, serious misconduct continues to be reported, the number of journal article retractions has risen, and a substantial …
One-Step Quantitative Molecular Approach for Detection of BCR/ABL1 Rearrangement and for Monitoring of Minimal Residual Disease in CML Patients: An Inter Laboratory Study
Authors: Filomena Daraio, Maria Teresa Bochicchio, Barbara Izzo, Claudia Venturi, Santa Errichiello, Francesca Crasto, Giovanna Rege-Cambrin, Roberta Lorenzatti, Carmen Fava, Fausto Castagnetti, Fabrizio Pane, Giovanni Martinelli, Giuseppe Saglio, Enrico Marco Gottardi
Journal: Blood (2016)
Laparoscopic and luminal endoscopic cooperative surgery can be a standard treatment for submucosal tumors of the stomach: a retrospective multicenter study
Authors: Tatsuo Matsuda, Souya Nunobe, Toshiyuki Kosuga, Hiroshi Kawahira, Noriyuki Inaki, Shuji Kitashiro, Nobutsugu Abe, Isao Miyashiro, Sayaka Nagao, Masahiko Nishizaki, Naoki Hiki
Journal: Endoscopy (2017)

<b>Background and study aims</b> We have developed a combined laparoscopic and luminal endoscopic surgery technique for resection of gastric submucosal tumors (SMTs) that can be performed without excessive resection of the stomach. In a multicenter retrospective study we aimed to evaluate the feasibility and safety of laparoscopic and endoscopic cooperative surgery (LECS) for gastric SMT resection. <b>Patients and methods </b>Between October 2007 and December 2011, 126 patients with gastric SMTs underwent LECS at 8 institutions. Patient demographics, tumor histopathologic characteristics, and operative and follow-up data were reviewed. <b>Results </b>16 tumors (12.7 %) were located in the upper third of the stomach, 88 (69.8 %) in the middle third, 5 (4.0 %) in the lower third, and 17 (13.5 %) at the esophagogastric junction. The mean (standard deviation [SD]) operation time for LECS was 190.2 (66.8) min, with a mean estimated blood loss of 15.1 (38.6) mL. In 2 cases (1.6 %), the procedure was converted to open surgery because of intra-abdominal adhesions or stenosis. Morbidity was found in 6 cases (4.8 %), including 2 leakage, 2 gastric stasis, 1 fever, and 1 cystitis. Histologically, a gastrointestinal stromal tumor (GIST) was found in 86 (68.3 %) cases. The median follow-up period was 54.7 months; no local or distant tumor recurrence was observed and all patients were alive. <b>Conclusions </b>LECS proved to be a safe and feasible procedure for the resection of gastric SMTs, with a reasonable operation time, low bleeding, and an acceptable complication rate in this multicenter study in Japan.
Sensorimotor contingencies do not replace internal representations, and mastery is not necessary for perception
Authors: Ernst Niebur
Journal: Behavioral and Brain Sciences (2001)

Sensorimotor contingencies are certainly of great importance for perception but they are no substitute for the internal representation of perceived information. I argue that internal, non-iconic representations of perceptions must, and do, exist and that sensorimotor contingencies are an integral part of them. Further, I argue that mastery of the sensory apparatus or environment is not a prerequisite for perception and that perception is possible in the absence of any control over the perceptual process.
Image Integration to Guide Wireless Endocardial LV Electrode Implantation for CRT
Authors: Jonathan M. Behar, Ben Sieniewicz, Peter Mountney, Daniel Toth, Maria Panayiotou, Simon Claridge, Kawal Rhode, Christopher Aldo Rinaldi
Journal: JACC. Cardiovascular imaging (2017)

Suboptimal left ventricular (LV) lead placement in myocardial scar (fibrosis) is associated with cardiac resynchronization therapy (CRT) nonresponse [(1)][1]. Image guidance (echocardiography and cardiac magnetic resonance [CMR]) avoiding fibrosis and targeting late mechanical activation may improve
Hepatitis B : Antiviral effect of entecavir 1 mg monotherapy in chronic hepatitis B: failure in prior treatment to nucleos(t)ide analogues (초)
Authors: Kwang Hun Ko, Byung Seok Lee, Seul Young Kim, Il Soon Jung, Kyu Seop Kim, Eaum Seok Lee, Seok Hyun Kim, Heon Young Lee
Journal: Clinical and Molecular Hepatology (2011)
Tax on sugary drinks in California cuts sales by 10%
Authors: Jacqui Wise
Journal: BMJ (2017)

Sales of sugar sweetened drinks in Berkeley, California, fell by almost 10% after the introduction of an excise tax, research published in PLoS Medicine has shown.1

In November 2014 Berkeley introduced a tax of one US cent per fluid ounce on beverages with added caloric sweeteners, which added on average 68 cents (£0.54; €0.64) to a $2 bottle of soda and 12 cents to a $1 can. In the first full year of the tax the city raised $1 416 973 (about $12 per capita), and this money is being used for child nutrition and community health programmes.

Berkeley was …
Impact of virologic factors on recurrence-free survival in HBV-related hepatocellular carcinoma after surgical resection: Post hoc analysis from a prospective study with long-term follow-up.
Authors: Nai-Jung Chiang, Miin-Fu Chen, Chin-Fu Hsiao, Po-Huang Lee, Pei-Jer Chen, Li-Tzong Chen
Journal: Journal of Clinical Oncology (2013)

e15032 Background: To investigate the impact of virologic factors on recurrence of post-operative hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in a prospective study population with long-term follow-up. Methods: 183 patients who had participated an adjuvant trial with detectable HBV DNA and of genotype B and/or C and negative for anti-hepatitis C antibody were included. All analyses were censored upon Dec 30 st , 2010. Results: The genotype distribution was B in 99 (54.1%), and C or mixed B+C (C/B+C) in 84 (45.9%). Genotype C/B+C infected patients had significantly higher incidence of HBeAg-seropositivity, high baseline HBV viral load, elevated serum ALT level, and underlying cirrhosis than patients with genotype B infection. The median time-to-recurrence (TTR) was 94.9 months and 33 months for genotype B and C/B+C infected patients, respectively (p=0.0495), and that for viral titer &lt;10 4 and ≥10 4 copies/mL was 129.8 and 39.9 months, respectively (p=0.059). Tumor size &gt;5 cm (p=0.008), presence of venous invasion (p=0.007) and moderately or poorly differentiation (p=0.039) were adverse prognostic factors for TTR in multivariate Cox’s regression analysis, but neither HBV DNA titer nor genotype. Of patients with tumor size ≤5 cm, HBV genotype C/B+C and baseline HBV viral load ≥10 4 copies/mL are significant adverse prognostic factors for TTR. On the other hand, microvascular invasion but not viral factor was prognostically significant for tumor size &gt;5 cm subpopulation. Compared with patients with neither genotype C/B+C infection nor baseline viral load ≥10 4 copies/mL, the relative risk for TTR of patients with either and both of the virological risk factors was 2.581 (p=0.068) and 3.384 (p=0.019), respectively, for the entire study cohort. Conclusions: HBV genotype and baseline viral load are associated with risk of recurrence in post-operative HCC, especially in patients with tumor ≤5 cm. Adjuvant anti-viral therapy may be more likely benefit to curatively resected small HBV-related HCC patients, which is currently tested in TCOG1206 trial.
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
Authors: Kiran Yanamandra, Tirth K. Patel, Hong Jiang, Suzanne Schindler, Jason D. Ulrich, Adam L. Boxer, Bruce L. Miller, Diana R. Kerwin, Gilbert Gallardo, Floy Stewart, Mary Beth Finn, Nigel J. Cairns, Philip B. Verghese, Ilana Fogelman, Tim West, Joel Braunstein, Grace Robinson, Jennifer Keyser, Joseph Roh, Stephanie S. Knapik, Yan Hu, David M. Holtzman
Journal: Science Translational Medicine (2017)

Administration of an anti-tau antibody to transgenic mice expressing human tau and to patients with tauopathy increased the concentration of tau in plasma.
TCTAP C-105 Step Wise of Stent Delivery After Wire Crossing CTO: Another Challenge Situation
Authors: Johan Senihardja, Bambang Budiono, Benny Mulyanto Setiadi, Agnes Lucia Panda, Janry Anton Pangemanan, Rizki Francis Pandelaki, Monique Priscilla Fransiska Rotty, Soetandar Widjaja, Iman Suhartono
Journal: Journal of the American College of Cardiology (2017)
Impact of DNA methylation and gene expression profile on treatment initiation and treatment free survival in early stage CLL.
Authors: Ritu Gupta, Lata Rani, Nitin Mathur, Ajay Gogia, Durai Sundar, Atul Sharma, Lalit Kumar
Journal: Journal of Clinical Oncology (2015)

e22073 Background: The contribution of epigenetic silencing of genes by aberrant methylation has been reported to be important in chronic lymphocytic leukemia (CLL). In the present study, gene methylation patterns were correlated with gene expression profile to identify genes which are differentially methylated and expressed in CLL and evaluated for their impact on treatment initiation and treatment free survival (TFS) in early stage CLL. Methods: Methylation status was assessed in PBMC from 14 treatment naïve CLL patients using 1x244k methylation array and gene expression status in 21 patients using 8x60K gene expression arrays (Agilent Technologies). CD19+ cells from 3 normal healthy controls were used as control. The genes showing differential expression in CLL were compared with their methylation status. Of these, 22 genes were evaluated in 93 early stage (0-II) CLL patients using RQ-PCR. The differences in the gene expression were compared using Mann-Whitney rank sum test, the relative risk of treatment initiation using Chi-square statistic and TFS using Kaplan-Meier survival analysis (SigmaPlot v13.0 software). A p-value of less than 5% was considered significant. Results: A total of 3196 genes were hypermethylated and 1020 genes hypomethylated; 1738 genes were upregulated and 2185 genes were downregulated in CLL. 119 genes with hypermethylation were down-regulated and included the genes involved in cell cycle regulation, p53 and TGF-b signaling pathways. Of the 22 genes evaluated by RQ-PCR, PAX9, CLLU1, LPL were overexpressed and CRY1, ADAM29 under expressed in UM CLL. With a median follow-up of 52 months, 36 patients progressed and were treated. SPRY1, CLLU1, PAX9, PMEPA, BLK and LPL were overexpressed in treated group. The relative risk of treatment initiation was higher with high expression of PAX9, PMEPA, CLLU1 and LPL. The TFS was significantly shorter in patients with high expression of CRY1 and PAX9. Conclusions: Our results show that the methylation patterns influence expression of genes involved in oncogenesis. Apart from CLLU1 and LPL, PAX9, CRY1, SPRY1, BLK and PMEPA were found to be of prognostic relevance in early stage CLL.
Outcomes of DLBCL Patients Entering Surveillance (without maintenance) after Immunochemotherapy in a Large Observational Study
Authors: Grzegorz S. Nowakowski, Matthew J Maurer, Carrie A Thompson, William R. Macon, Susannah Howlett, Thomas M. Habermann, Umar Farooq, Luis Porrata, Sergei Syrbu, Stephen Ansell, Thomas E. Witzig, James R Cerhan, Brian K Link
Journal: Blood (2016)
The Theory of Event Coding (TEC)'s framework may leave perception out of the picture
Authors: J. Scott Jordan
Journal: Behavioral and Brain Sciences (2001)

Hommel et al. propose that action planning and perception utilize common resources. This implies perception should have intention-relative content. Data supporting this implication are presented. These findings challenge the notion of perception as “seeing.” An alternative is suggested (i.e., perception as distal control) that may provide a means of integrating representational and ecological approaches to the study of organism-environment coordination.
Increasing Resident Autonomy Without Compromising Patient Safety
Authors: Rebecca L. Gunter, Jacob A. Greenberg
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Role of p38 MAPK and Tie2 in the Pathogenesis of MDS and Their Inhibition by Dual Inhibitor ARRY-614.
Authors: Shannon L Winski, LouAnn Cable, Grant Hogeland, Suzy Brown, Dan Weaver, Jenn Garrus, Susan Rhodes, Lara Maloney, Ann Marie Ptaszynski, H. Jean Khoury, Mikkael A. Sekeres, Rami S. Komrokji, Guillermo Garcia Manero, David Chantry
Journal: Blood (2012)
Histone Deacetylase Inhibitors Potentiate the Lethality of the Irreversible Proteasome Inhibitor Carfilzomib In Mantle Cell Lymphoma Cells In Vitro and In Vivo
Authors: Girija Dasmahapatra, Dmitry Lembersky, Jonathan W. Friedberg, Richard I Fisher, Paul Dent, Steven Grant
Journal: Blood (2010)
CELLULAR MECHANISMS OF PROTEIN METABOLISM IN THE NEPHRON
Authors: Jean Oliver, Muriel MacDowell, Yin Chen Lee
Journal: The Journal of Experimental Medicine (1954)

When proteins pass the glomerular filter they are in part directly absorbed by the epithelial cells of the proximal convolution of the nephron with no apparent alteration of the cytological pattern. If the capacity of the tubule cells to thus absorb protein from the tubule fluid is exceeded either by the amount or the nature of the protein the accessory mechanism of droplet formation occurs. This accessory mechanism is an intracellular process in which cytoplasmic elements, the mitochondria with their enzymes, and the absorbed protein combine to form droplets. As the droplets form and then disappear from the renal cells their evolution presents a constantly changing picture depending on the varying nature of their protein and cytoplasmic content. The droplet is therefore not a cytological structure of fixed characteristics (hyaline droplet) but a locus of metabolic activity and varied structural aspect.
Physician Adherence to Breast Cancer Screening Recommendations
Authors: Deborah Grady, Rita F. Redberg
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Review: Metformin is linked to reduced mortality in type 2 diabetes with comorbid CKD and CHF
Authors: Sina Jasim, Steven A Smith
Journal: Annals of Internal Medicine (2017)

Source Citation Crowley MJ, Diamantidis CJ, McDuffie JR, et al. Clinical outcomes of metformin use in populations with chronic kidney disease, congestive heart failure, or chronic liver disease: a systematic review. Ann Intern Med. 2017:166;191-200. 28055049
Prevalence of Celiac Disease Autoimmunity Among Adolescents and Young Adults in China
Authors: Juanli Yuan, Chunyan Zhou, Jinyan Gao, Jingjing Li, Fenglian Yu, Jun Lu, Xin Li, Xiaozhong Wang, Ping Tong, Zhihua Wu, Anshu Yang, Yonghong Yao, Sarah Nadif, Heng Shu, Xu Jiang, Yujie Wu, Luud Gilissen, Hongbing Chen
Journal: Clinical Gastroenterology and Hepatology (2017)