Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs
Authors: Shixing Tang, Haiying Wang
Journal: Annals of Internal Medicine (2018)

Letters16 January 2018Presence of Human Hepegivirus-1 in a Cohort of People Who Inject DrugsShixing Tang, MD, PhD and Haiying Wang, PhDShixing Tang, MD, PhDSouthern Medical University, Guangzhou, China (S.T., H.W.)Search for more papers by this author and Haiying Wang, PhDSouthern Medical University, Guangzhou, China (S.T., H.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0526 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As researchers investigating human hepegivirus-1 (HHpgV-1) in China, we found Kandathil and colleagues' article (1) about this virus in patients co-infected with hepatitis C virus (HCV) and HIV-1 of great interest and have several comments.First, the authors found that 10.9% of U.S. injection drug users had positive results for HHpgV-1 RNA. This prevalence is much higher than in the United Kingdom (1.7%) (2) and even higher than what we found in China (5.7%), indicating the importance of determining high-risk populations or subpopulations as well as regions in which HHpgV-1 infection is epidemic.Second, it is believed ...References1. Kandathil AJ, Breitwieser FP, Sachithanandham J, Robinson M, Mehta SH, Timp W, et al. Presence of human hepegivirus-1 in a cohort of people who inject drugs. Ann Intern Med. 2017;167:1-7. [PMID: 28586923]. doi:10.7326/M17-0085 LinkGoogle Scholar2. Bonsall D, Gregory WF, Ip CL, Donfield S, Iles J, Ansari MA, et al. Evaluation of viremia frequencies of a novel human pegivirus by using bioinformatic screening and PCR. Emerg Infect Dis. 2016;22:671-8. [PMID: 26982117] doi:10.3201/eid2204.151812 CrossrefMedlineGoogle Scholar3. Kapoor A, Kumar A, Simmonds P, Bhuva N, Singh Chauhan L, Lee B, et al. Virome analysis of transfusion recipients reveals a novel human virus that shares genomic features with hepaciviruses and pegiviruses. MBio. 2015;6:e01466-15. [PMID: 26396247] doi:10.1128/mBio.01466-15 CrossrefMedlineGoogle Scholar4. Berg MG, Lee D, Coller K, Frankel M, Aronsohn A, Cheng K, et al. Discovery of a novel human pegivirus in blood associated with hepatitis C virus co-infection. PLoS Pathog. 2015;11:e1005325. [PMID: 26658760] doi:10.1371/journal.ppat.1005325 CrossrefMedlineGoogle Scholar5. Wang H, Wan Z, Xu R, Guan Y, Zhu N, Li J, et al. A novel human pegivirus HPgV-2 (HHpgV-1) is tightly associated with HCV infection and HCV/HIV-1 co-infection. Clin Infect Dis. 2017. [PMID: 29020289] doi:10.1093/cid/cix748 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Southern Medical University, Guangzhou, China (S.T., H.W.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0526. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPresence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs Abraham J. Kandathil , Florian P. Breitwieser , Jaiprasath Sachithanandham , Matthew Robinson , Shruti H. Mehta , Winston Timp , Steven L. Salzberg , David L. Thomas , and Ashwin Balagopal Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs Abraham J. Kandathil , David L. Thomas , and Ashwin Balagopal Presence of Human Hepegivirus-1 in a Cohort of People Who Inject Drugs Daniel Candotti , Xuelian Deng , Tingting Li , Syria Laperche , and Virginie Sauvage Metrics Cited byInfection of human pegivirus 2 (HPgV-2) is associated with hepatitis C virus but not hepatitis B virus infection in people who inject drugs 16 January 2018Volume 168, Issue 2Page: 157-158KeywordsBloodDrugsHIV-1Hepatitis BHepatitis C virusInjecting drug usersPopulation statisticsRNAViral loadViral replication ePublished: 16 January 2018 Issue Published: 16 January 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...