tbuckley/cabot-search huggingface dataset:
THU0741-HPR Placebo and nocebo effects induced by contextual factors. a survey on beliefs and attitudes of italian musculoskeletal physiotherapists
Authors: G Rossettini, T Geri, A Palese, M Fiorio, A Viceconti, M Testa
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Context effects are well known and were described as integral part of the clinical setting (1). The conscious use of contextual factors (CF) has been recently proposed as an effective modality capable to influence the physiotherapy outcome by facilitation of placebo responses. (2) To date, the knowledge about CF adoption in clinical practice of physical therapists is absent. <h3>Objectives</h3> The aim of this study was to investigate frequency of use, beliefs and attitudes about contextual factors among Italian physical therapists specialized in manual therapy (OMTs) <h3>Methods</h3> An invitation to participate in an online survey was sent to 906 OMTs through the database of the Master in Musculoskeletal Rehabilitation (MRDM) of University of Genova by SurveyMonkey Software®. These likely correspond to more than 85% of the whole OMTs population in Italy. A 17 items questionnaire and two clinical scenarios assessed behaviour, beliefs and attitudes of OMTs about CF adoption in clinical practice and data were analysed by descriptive statistic. <h3>Results</h3> 906 OMTs were invited to participate in the survey and 558 responded (62%). The majority of OMTs uses CF in their practice frequently (52%). They believe that an actual effect of CF can occur in acute pain (57%), chronic pain (78%) and rheumatologic disorders (56%). OMTs consider the use of CF ethically acceptable when it exerts beneficial psychological effects and their effectiveness was shown during clinical experience (31%). They disagree on the adoption of CF when they are based on deception, undermine the trust between OMT and patients, create legal problems or produce side effects (17%). 38% of respondents do not communicate the use of CF to their patients and they adopt CF as addition to other physical therapy interventions with the aim of optimizing clinical responses (20%). Expectation and psychological mechanisms are believed to be the main aspects behind placebo and nocebo effects induced by CF (7%). <h3>Conclusions</h3> The use of CF is quite common among Italian OMTs and they mostly had positive attitudes towards their use and effectiveness. <h3>References</h3> Di Blasi Z, Harkness E, Ernst E, Georgiou A, Kleijnen J. Influence of context effects on health outcomes: a systematic review. Lancet. 2001 Mar 10;357(9258):757–62. Testa M, Rossettini G. Enhance placebo, avoid nocebo: How contextual factors affect physiotherapy outcomes. Man Ther. 2016;24:65–74. <h3>Disclosure of Interest</h3> None declared
Cancers of the Nasopharynx and Oropharynx and Formaldehyde Exposure
Authors: C H Tamburro, W J Waddell
Journal: JNCI Journal of the National Cancer Institute (1987)

Cancers of the Nasopharynx and Oropharynx and Formaldehyde Exposure Get access Carlo H. Tamburro, Carlo H. Tamburro Search for other works by this author on: Oxford Academic PubMed Google Scholar William J. Waddell William J. Waddell Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 79, Issue 3, September 1987, Page 605, https://doi.org/10.1093/jnci/79.3.605 Published: 01 September 1987
A Spontaneous Fibrosarcoma of the Foreleg and Paw in a G3H Mouse
Authors: Edwards, Jesse E., Dalton, Albert J., White, Julius, White, Thomas N.
Journal: JNCI Journal of the National Cancer Institute (1942)

Journal Article A Spontaneous Fibrosarcoma of the Foreleg and Paw in a G3H Mouse Get access Jesse E. Edwards, Jesse E. Edwards research fellow Search for other works by this author on: Oxford Academic PubMed Google Scholar Albert J. Dalton, Albert J. Dalton cytologist Search for other works by this author on: Oxford Academic PubMed Google Scholar Julius White, Julius White senior biochemist Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas N. White Thomas N. White associate biophysicist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 3, Issue 2, October 1942, Pages 191–198, https://doi.org/10.1093/jnci/3.2.191 Published: 01 October 1942
FRI0643 Enthesitis and foot disability in patients with ankylosing spondylitis
Authors: A Serce, A Bal, D Dulgeroglu, A Cakci
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Enthesitis is a primary clinical feature of ankylosing spondylitis (AS). Lower extremity enthesopathy may cause foot pain and functional disability. Detection of enthesitis by using physical examination may be insufficient. Musculoskeletal ultrasonography is a noninvasive and low-cost method for detecting enthesitis readily. <h3>Objectives</h3> The aims of this study were to evaluate enthesitis by using musculoskeletal ultrasonography and foot disability in patients with AS, to compare healthy controls, and to determine the correlation of enthesitis score and foot function with disease activity and functional status. <h3>Methods</h3> In this study, 101 patients with AS and 42 healthy controls were examined for enthesal site abnormalities by using gray-scale ultrasonography. The findings were assessed by using the Glasgow Ultrasound Enthesitis Scoring System (GUESS). The foot function index (FFI), which comprised of pain, disability, and activity limitation subscales, was measured in all the patients with AS and healthy controls for assessment of foot function. Disease activity and functional status were assessed using the Bath AS Disease Activity Index (BASDAI) and Bath AS Functional Index (BASFI), respectively, in patients with AS. <h3>Results</h3> The median GUESS score was 8.00 (1.00–23.00), and, the median total FFI and scores in all the pain, disability, and activity limitation subscales were 14.70 (0.00–75.20), 16.60 (0.00–82.80), 16.10 (0.00–84.40), and 4.00 (0.00–60.00), respectively in patients with AS. The GUESS score, total FFI, and all the subscales scores were significantly higher in the patients with AS than in the controls (p=0.00). GUESS score showed no correlation with BASDAI and BASFI. In patients with AS, total FFI and scores for all subscales showed positive correlations between BASDAI and BASFI, respectively (p=0.00, <i>r</i>=0,66; p=0.00, <i>r</i>=0,0,50; p=0.00, <i>r</i>=0,59; p=0.00, <i>r</i>=0,31; p=0.00, <i>r</i>=0,60; p=0.00, <i>r</i>=0,54; p=0.00, <i>r</i>=0.57; p=0.00, <i>r</i>=0.50). <h3>Conclusions</h3> The severities of enthesitis and foot disability were higher in patients with AS. Patients with AS may undergo ultrasonographic examination for enthesal foot involvement. Foot disability is related with disease activity and function. Foot involvement and disability should be evaluated comprehensively and managed properly. <h3>References</h3> Balint PV, Kane D, Wilson H, McInnes IB, Sturrock RD. Ultrasonography of enthesal insertions in the lower limb in spondyloarthropathy. Ann Rheum Dis 202;61:905–910. Borman P, Koparal S, Babaoğlu S, Bodur H. Ultrasound detection of entheseal insertions in the foot of patients with spondyloarthropathy. Clin Rheumatol 2006;25:373–377. <h3>Disclosure of Interest</h3> None declared
FRI0556 Long-term effects of back extensor strengthening exercises on quality of life in women with osteoporosis
Authors: SA Raeissadat, A Khalili, L Sedighipour, M Heidari Almasi
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> A correlation exists between bone mineral density and physical activity level, suggesting that exercise may increase peak bone mass. Back extensor strength has been of major importance and had a strong effect on quality of life in this population. <h3>Objectives</h3> The aim of the present study was to evaluate the long-term effect of back extensor strengthening exercises on health-related quality of life (QOL) in women with osteoporosis. <h3>Methods</h3> In this randomized clinical trial, 183 women with osteoporosis were treated with pharmacotherapy and weight-bearing and balance-training exercises. The case group additionally performed back extensor exercises at home. Patients filled out the Persian version of the Short Form (SF-36) QOL questionnaire at baseline and 6 months post treatment. <h3>Results</h3> At the end, all physical and mental parameters of the SF-36 questionnaire improved significantly in the case group, except for one subscale of mental health, compared to the control group. In the control group, only some physical health dimensions (bodily pain, role limitation, physical function, vitality), and mental health status as a mental health subscale improved. <h3>Conclusions</h3> considering a major impact of back extensor exercises on improving QOL in women with osteoporosis over the long term, these exercises should be prescribed in routine management of these patients. <h3>Disclosure of Interest</h3> None declared
FRI0679 Whole spine and SIJ MRI of psoriatic arthritis patients: descriptive study of the spine, and sacroiliac joints involvement in a cross sectional large cohort
Authors: V Furer, M Stark, H Matz, D Levartovsky, J Wollman, I Wigler, H Sarbagil-Maman, D Paran, I Kaufman, M Anouk, S Borok, R Zemah, A Broyde, G Flusser, I Druckmann, O Elkayam, I Eshed
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Detection of axial disease has important implications. Data on the structural changes of the spine and SIJ in PsA is mainly based on plain XR and MRI of SIJ. The prevalence and distribution of spinal changes in PsA as detected by MRI is largely unknown. <h3>Objectives</h3> To evaluate acute and structural changes in spine and SIJ by whole spine MRI performed in a consecutive clinical cohort of PsA. <h3>Methods</h3> Adult PsA (CASPAR criteria) patients were enrolled in the study. All underwent clinical exam, CRP, HLA-B27 tests, and MRI of the entire spine and SIJ. Spinal sagittal T1-W, STIR and semi-coronal T1-W and T2-W with fat saturation sequences of the SIJ were performed. The spine was scored for the presence of syndesmophytes, bone marrow edema (BME)/fatty corners and enthesitis. SIJS were scored (Berlin score) for the presence of BME, fatty replacement, erosions, sclerosis, and ankylosis. Findings were further categorized into active sacroiliitis (ASAS<sup>1</sup>), structural sacroiliitis, and spinal findings compatible with SpA (≥3 BME or ≥4 fatty corners<sup>2</sup>). All MRIs were evaluated by an experienced musculoskeletal radiologist, blinded to clinical data. Data were analyzed by SPSS Version 20.0. <h3>Results</h3> Ninety six patients completed the study.(Table1) Active/structural/total sacroiliitis was detected in 26%/11.5%/37.5% of patients, respectively. Spinal SpA was demonstrated in 15.6%.(Table 2) Isolated spinal changes were detected in 2.1% of the cohort. Presence of inflammatory back pain (IBP) by ASAS correlated with the prevalence of active sacroiliitis (p 0.024) and SpA (axial/SIJ) (p 0.003). The extent of psoriasis severity (PASI) correlated with both SIJ and whole spine SpA changes. (<i>p 0.02 for both</i>) Gender differences or biologic therapy did not affect the prevalence of SIJ or spine involvement. <h3>Conclusions</h3> In the present PsA cohort, active and structural sacroiliitis was more prevalent vs typical spinal SpA changes. In particular, there was a paucity of SpA changes in the cervical spine. The most prominent axial findings included fatty corners and syndesmophytes. IBP presence and extensive skin disease correlated with SpA axial and SIJ changes. <h3>References</h3> Lambert RG. Ann Rheum Dis. 2016,75. Hermann KG. Ann Rheum Dis 2012.71. <h3>Disclosure of Interest</h3> None declared
DnaSP 6: DNA Sequence Polymorphism Analysis of Large Data Sets
Authors: Julio Rozas, Albert Ferrer-Mata, Juan Carlos Sánchez-DelBarrio, Sara Guirao-Rico, Pablo Librado, Sebastián E Ramos-Onsins, Alejandro Sánchez-Gracia
Journal: Molecular Biology and Evolution (2017)

We present version 6 of the DNA Sequence Polymorphism (DnaSP) software, a new version of the popular tool for performing exhaustive population genetic analyses on multiple sequence alignments. This major upgrade incorporates novel functionalities to analyze large data sets, such as those generated by high-throughput sequencing technologies. Among other features, DnaSP 6 implements: 1) modules for reading and analyzing data from genomic partitioning methods, such as RADseq or hybrid enrichment approaches, 2) faster methods scalable for high-throughput sequencing data, and 3) summary statistics for the analysis of multi-locus population genetics data. Furthermore, DnaSP 6 includes novel modules to perform single- and multi-locus coalescent simulations under a wide range of demographic scenarios. The DnaSP 6 program, with extensive documentation, is freely available at http://www.ub.edu/dnasp.
THU0281 Long-term prognosis and predictingfactors of chinese patients with systemic lupus erythematosus: a multi-center cohort study from cstar registry
Authors: M Li, Z Wang, Y Wang, X Zeng
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Objectives</h3> To investigate the long-term outcomes, both mortality and damage, and related prognostic factors of patients with systemic lupus erythematosus (SLE) in the CSTAR (Chinese SLE Treatment and Research group) registry cohort. <h3>Methods</h3> All of the patients were enrolled from April 2009 to February 2010. They were followed up at clinic and were telephone interviewed at the endpoint. Demographic data, clinical manifestations, activity (SLEDAI-2K), damage scores (SLLIC/Damage Index), and medications were collected. Data were censored at the last clinic visit or telephone interview. Survival rates were studied by Kaplan-Meier method, and COX proportional hazard model was adopted to perform the analysis of predicting factors for mortality. <h3>Results</h3> A total of 2104 patients were recruited at baseline, and 1494 patients were successfully followed up. The cumulative 1, 3 and 5-year survival ratesfrom diagnosis were 99.0%, 98.1% and 97.1%. 78 patients died during follow-up, and the main death causes were infection (34.6%), active disease (26.9%), cardiovascular and cerebrovascular events (6.41%) and malignancy (5.13%). At entry, 247 patients presented with irreversible organ damage and it increased to 398 patients at the endpoint. The major accumulated organ damages were renal (25.9%), musculoskeletal (20.2%), neuropsychiatric (12.4%), and pulmonary (10.8%) damage. Cox regressionshowed that male, late onset age (≥50y), onset to diagnosis time ≥1 year, previous organ damage, renal involvement, pulmonary arterial hypertension, neuropsychiatric involvement, serositis and the number of involved organ systems ≥3predict for higher mortality. <h3>Conclusions</h3> Long-term survival rates have improved for Chinese SLE patients. Early diagnosis, preventing fromthe emerging systemic organ involvements and organ damagecould be the treating target for the management of SLE patients in China. <h3>Disclosure of Interest</h3> None declared
Abstract 4175: Quantitative Assessment of Myocardial Blood Flow Using Adenosine Triphosphate Stress Multidetector-row Computed Tomography in Coronary Artery Disease
Authors: Fumiaki Shikata, Hiroshi Imagawa, Teruhito Kido, Akira Kurata, Hiroshi Higashino, Yuma Inoue, Masahiro Ryugo, Mitsugi Nagashima, Teruhito Mochizuki, Kanji Kawachi
Journal: Circulation (2008)

Introduction: The purpose of this study was to test the hypothesis that cardiac multidetector-row computed tomography (MDCT) technology can assess myocardial perfusion quantitatively using adenosine triphosphate (ATP) load technique. Methods: Ten patients (median age 71 (range 65–79) years) who were scheduled for surgical revascularization, underwent cardiac electrocardiography-gated MDCT using ATP-load technique. The patients with unstable angina and myocardial infraction were excluded. Myocardial infarction was detected by late gadolinium enhancement MRI which was assessed before MDCT. Myocardial blood flow (MBF) was estimated from the slope of the linear regression equation with Patlak plots analysis. MBF results were compared to the presence of stenoses more than 75% on coronary angiography (CAG) and moderate to severe myocardium ischemia on stress thallium-201 myocardial perfusion scintigraphy (MPS). Results: The overall mean MBF was 1.64±0.61 ml/g/min. Mean MBF in territories with stenosis on CAG was 0.81±0.49 ml/g/min, while mean MBF in territories without stenosis was 1.83±0.64 ml/g/min (p&lt;0.01). Mean MBF in territories with moderate to severe ischemia on MPS was 0.76±0.49 ml/g/min, while mean MBF in territories without ischemia was 2.15±0.66ml/g/min (p&lt;0.01). When the cut off value of MBF was set at 1.5 ml/g/min, there was good correlation between MBF vs CAG, and MBF and MPS. MBF vs CAG: sensitivity=71.4%, specificity=82.6%; MBF vs MPS: sensitivity=85.7%, specificity=87.0%. Conclusions: This study proposed the possibility of MDCT to quantify myocardial blood flow using ATP in coronary artery disease. Our data suggested that the ATP stress MDCT has an advantage in the assessment of CAD to evaluate both coronary artery stenoses and myocardial perfusion information in one modality.
AB0510 Neuropsychiatric manifestations and disease activity in polish cohort of systemic lupus erythematosus patients
Authors: K Pawlak-Bus, M Spalek, P Leszczynski
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Neuropsychiatric systemic lupus erythematosus (NPSLE) is defined as wide range of neurological and psychiatric symptoms due to inflammation and ischemic processes. It is difficult to recognize primary NPSLE because of multiple central and peripheral symptoms. <h3>Objectives</h3> The aim of the study was to identified and classified the group of NPSLE patients with evaluation of disease activity. <h3>Methods</h3> We observed clinical neuropsychiatric (NP) manifestations in the cohort of 128 Polish patients with SLE. All patients with suspicion of NP symptoms had neuropsychological and imaging examinations. Symptoms of NPSLE were observed in 38 (30%) patients (34 female and 4 male) with average age 38±6 years (range 18–61 yrs), average disease duration 6,6±5,6 years (range 1,0 - 18,0 yrs). Patients were treated with oral and pulse glucocorticoids (GC) and 89% of them standard immunosuppressive drugs (CYC, MMF, AZA,MTX, CsA). As a background therapy 82% of these patients were on chloroquine or hydroksychloroquine (CQ/HCQ). All patients were assessed according to Systemic Lupus Erythematosus Disease Activity Index by SLEDAI (version 2000), Physical Global Assessment (PGA) and damage index (SDI). <h3>Results</h3> Central and peripheral NPSLE symptoms were recognized and categorized (Tab 1). All NPSLE patients had symptoms from central nervous system, but only 16% (n=6) of them had peripheral lupus manifestations. Mean SLEDAI score at NP event was very high 29±9,6, but mean SLEDAI score without NP symptoms was 15±8,3 and was connected with musculoskeletal, mucocutaneous, renal and hematological domains respectively n=29, 76%; n=23, 60%; n=11, 29%; n=8, 21%. Low disease activity was estimated at 3% of patients examined.Most of lupus patients (n=37, 97%) had moderate or high disease activity regardless of NP symptoms. In our study group lupus patients during NPSLE symptoms were immunologically active with increased anti-dsDNA antibodies (n=30, 78%) and/or lower complements C3 and/or C4 levels (n=21, 55%). <h3>Conclusions</h3> In Polish lupus cohort we observed more frequently lupus-related primary neuropsychiatric symptoms from central nervous system, especially cognitive dysfunctions, mood disorders, cerebrovascular events. Clinical activity of NPSLE patients was rather high and definitely most of patients were immunologically active despite aggressive immunosuppressive treatment and with standard background therapy. <h3>Disclosure of Interest</h3> None declared
Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies
Authors: J Mark FitzGerald, Eugene R Bleecker, Andrew Menzies-Gow, James G Zangrilli, Ian Hirsch, Paul Metcalfe, Paul Newbold, Mitchell Goldman
Journal: The Lancet Respiratory Medicine (2017)
A Precision Medicine Approach Incorporating Both Molecular and In Vitro Functional Data to Treat Patients with Relapsed/Refractory Acute Myeloid Leukemia
Authors: Pamela S. Becker, Sylvia Chien, Timothy J Martins, Andrew Herstein, Cody Hammer, Taylor Sekizaki, Vivian Oehler, C. Anthony Blau, Bradley A Patay, Andrew Carson, Paul C. Hendrie, Roland B. Walter, Mary-Elizabeth M. Percival, Soheil Meschinchi, Katherine Tarlock, Ryan D Cassaday, Kelda Gardner, Heather Smith, Andrea M. Perdue, Frederick R. Appelbaum, Jerald P. Radich, Elihu H. Estey
Journal: Blood (2016)
AB0081 Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase
Authors: D Damgaard, ME Bjørn, CH Nielsen
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Protein citrullination is catalysed by pepdidylarginine deiminase (PAD) and plays an important pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA), and possibly in other inflammatory diseases. PAD activity is dependent on calcium and reducing conditions. <h3>Objectives</h3> To determine the ability of H<sub>2</sub>O<sub>2</sub> and reactive oxygen species (ROS) induced by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase to regulate PAD activity. <h3>Methods</h3> Activity of recombinant human (rh) PAD2, rhPAD4 and PADs released from phorbol 12-myristate 13-acetate (PMA)-stimulated leucocytes was measured using an in-house PAD activity assay detecting citrullination of fibrinogen. PAD2 released from cells was measured using a luminex-based assay. The NADPH oxidase inhibitor diphenyleneiodonium (DPI) was used to inhibit ROS production in cells. <h3>Results</h3> At concentrations above 40 μM, H<sub>2</sub>O<sub>2</sub> inhibited the catalytic activity of reduced rhPAD2 and rhPAD4. The inhibitory effect increased with increasing H<sub>2</sub>O<sub>2</sub> concentration, reaching complete abrogation at 600 μM. PMA-stimulated leucocytes showed markedly higher PAD activity following inhibition of ROS formation with DPI. At a concentration of 10,000 μM, exogenously added H<sub>2</sub>O<sub>2</sub> inhibited the catalytic activity of PAD released from PMA-stimulated leukocytes. <h3>Conclusions</h3> The ROS H<sub>2</sub>O<sub>2</sub> directly inhibits enzymatic activity of PAD, and generation of ROS by NADPH oxidase down-regulates the activity of PAD released from stimulated leucocytes. This mechanism may play an important role in preventing hypercitrullination of proteins and thereby generation of self-antigens in RA. <h3>Disclosure of Interest</h3> None declared