tbuckley/cabot-search huggingface dataset:
Prenatal Ultrasonography and the Incidence of Autism Spectrum Disorder
Authors: Sara Jane Webb, Pierre D. Mourad
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Un algorithme hautement sensible et hautement spécifique pour la détection d'angiodysplasies en vidéo-capsule endoscopique du grêle
Authors: R Leenhardt, P Vasseur, C Li, G Rahmi, F Cholet, JC Saurin, X Amiot, JM Delvaux, C Duburque, R Gérard, C Leandri, S Lecleire, JP Le Mouel, F Mesli, I Nion Larmurier, S Sacher-Huvelin, G Vanbiervliet, P Marteau, O Romain, A Histace, X Dray
Journal: Endoscopy (2018)

La vidéo capsule endoscopique (VCE) est un examen de référence pour l'exploration non invasive de l'intestin grêle. Néanmoins, chaque enregistrement comprenant en moyenne 50000 images de l'intestin grêle, l'interprétation d'une VCE s'avère fastidieuse et chronophage, et est associée à un risque non négligeable de lésions manquées. Le développement d'algorithmes de détection des lésions assistés par ordinateur est devenu un domaine actif de recherche en VCE. Les angiodysplasies (AGD) gastro-intestinales sont les lésions vasculaires de l'intestin grêle les plus fréquentes, et sont associées à un risque élevé de saignement digestif. L'objectif de cette étude était de développer un outil de diagnostic assisté par ordinateur pour la détection des AGD de l'intestin grêle en VCE.
Rapid Change in Fentanyl Prevalence in a Community-Based, High-Risk Sample
Authors: Andrea A. Jones, Kerry Jang, William J. Panenka, Alasdair M. Barr, G. William MacEwan, Allen E. Thornton, William G. Honer
Journal: JAMA Psychiatry (2018)

This prospective longitudinal analysis of people living in an impoverished neighborhood finds that fentanyl-positive urine samples increased rapidly during a 5-month period while opiate-positive samples declined.
Facteurs prédictifs de l'échec de traitement endoscopique des traumatismes des voies biliaires post-cholécystectomie
Authors: N El Khabiz, FZ Moumayez, G Kella Bennani, FZ Chabib, I Benelbarhdadi, FZ Ajana
Journal: Endoscopy (2018)

Le développement de l'endoscopie interventionnelle représente actuellement une alternative à une nouvelle intervention chirurgicale en cas de sténose biliaire bénigne après une cholécystectomie notamment par voie laparoscopique, Le but du traitement endoscopique sera de lever l'obstacle mécanique et de calibrer définitivement le canal biliaire. Y a-t-il de facteurs prédictifs d'échec de traitement endoscopique qui peuvent faire recourir le malade le risque d'une nouvelle intervention chirurgicale?
Indications de la coloscopie selon les critères de l'EPAGE II: Les indications sont-elles toutes pertinentes?
Authors: K Agar, L Hamzaoui, M Medhioub, S Jardak, K Amal, MM Azouz
Journal: Endoscopy (2018)

Avec l'émergence des cancers colorectaux, la coloscopie est devenue l'examen de référence pour le dépistage, le diagnostic et même le traitement endoscopique des polypes et certains cancers in situ. Mais, les indications deviennent parfois abusives vu la disponibilité de cet examen d'une part, et la crainte de passer à côté d'une pathologie néoplasique d'autre part.
New Insights into the Molecular Characteristics of Pulmonary Carcinoids and Large Cell Neuroendocrine Carcinomas, and the Impact on Their Clinical Management
Authors: Jules L Derks, Noémie Leblay, Sylvie Lantuejoul, Anne-Marie C. Dingemans, Ernst-Jan M Speel, Lynnette Fernandez-Cuesta
Journal: Journal of Thoracic Oncology (2018)
Abstract 03: Choice Architecture Increases WIC Fruit and Vegetable Purchases in a Latino Community: Randomized, Controlled Corner Store Intervention
Authors: Anne N Thorndike, Oliver-John M Bright, Melissa A Dimond, Ronald Fishman, Douglas E Levy
Journal: Circulation (2016)

Background: In 2009, the Special Supplemental Nutrition program for Women, Infants, and Children (WIC) increased access to healthy foods by providing cash-value vouchers for fruit/vegetables, but improving access alone is not sufficient to reduce disparities in food choices and obesity among low-income families. We hypothesized that making fresh produce more visible and of better quality in corner stores would increase their WIC fruit/vegetable sales. Methods: We conducted a randomized, controlled trial of 6 WIC-certified corner stores in a low-income, Latino community. Three stores were assigned to “choice architecture” intervention that increased visibility and quality of fresh fruit/vegetables. Primary outcome was WIC fruit/vegetable voucher (FVV) sales, comparing changes in sales trends from baseline (Dec. 2012-Oct. 2013) to follow-up (Dec. 2013-Apr. 2014) for intervention vs. control stores. Secondary outcomes, from customer exit surveys at all 6 stores (N=575), were changes between baseline and follow-up in self-reported fresh fruit/vegetable purchases by customers on WIC or Supplemental Nutrition Assistance Program (SNAP). Results: WIC FVV sales decreased in both intervention and control stores during baseline but increased in the 3 intervention stores after implementing choice architecture (Figure). In exit surveys, 23% of all corner store customers reported using WIC, and 37% used SNAP. Compared to baseline, intervention store customers on SNAP increased purchase of fruit/vegetables at follow-up more than SNAP customers at control stores (6% vs. -15%, p=0.007). For WIC customers, there was a similar but not statistically significant difference between intervention and control (18% vs. -2%, p=0.11). Conclusion: A simple choice architecture intervention increased purchases of fruit/vegetables by corner store customers using WIC. Policies that incentivize WIC-certified stores to stock and prominently display good quality fresh produce could improve healthy choices of low-income families.
Stat Bite
Authors: Lou Fintor
Journal: JNCI Journal of the National Cancer Institute (1992)

Stat BiteHIV-Related Non-Hodgkin's Lymphoma Get access Lou Fintor Lou Fintor Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 1, 1 January 1992, Page 9, https://doi.org/10.1093/jnci/84.1.9 Published: 01 January 1992
Stroke Risk in Patients With Reduced Ejection Fraction After Myocardial Infarction Without Atrial Fibrillation
Authors: João Pedro Ferreira, Nicolas Girerd, John Gregson, Ichraq Latar, Abhinav Sharma, Marc A. Pfeffer, John J.V. McMurray, Azmil H. Abdul-Rahim, Bertram Pitt, Kenneth Dickstein, Patrick Rossignol, Faiez Zannad
Journal: Journal of the American College of Cardiology (2018)
Apport de la manométrie oesophagienne tridimensionnelle au cours de la procédure de myotomie perorale endoscopique
Authors: M Barret, MA Guillaumot, C Leandri, S Leblanc, F Prat, S Chaussade
Journal: Endoscopy (2018)

La myotomie perorale endoscopique (POEM) est une technique largement utilisée dans le traitement de l'achalasie du sphincter inférieur de l'oesophage. Cependant, on observe environ 10% d'échecs primaires de ce traitement. Ces échecs pourraient être expliqués par une myotomie insuffisante sur le versant gastrique, du fait des difficultés de création du tunnel qui peuvent être rencontrées au-dessous du cardia. Nous avons évalué la faisabilité et l'intérêt d'un examen manométrique per-endoscopique au cours du POEM pour optimiser la longueur de la myotomie gastrique endoscopique.
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [I]: anti-tumor necrosis factor-α agents)
Authors: J.W. Baddley, F. Cantini, D. Goletti, J.J. Gómez-Reino, E. Mylonakis, R. San-Juan, M. Fernández-Ruiz, J. Torre-Cisneros
Journal: Clinical Microbiology and Infection (2018)
Quality of Life in Fit Elderly Patients with Chronic Lymphocytic Leukemia (CLL) Receiving Oral Fludarabine-Based Regimens As First Line Therapy: Australasian Leukaemia and Lymphoma Group (ALLG) CLL5 Trial
Authors: Suneet Sandhu, Devinder Gill, Paul David Turner, William E. P. Renwick, Maya Latimer, Naomi Mackinlay, Leanne Berkahn, David R Simpson, Philip Campbell, Cecily Forsyth, Gavin Cull, Rosemary Harrup, Giles Best, Mathias Bressel, Juliana Di Iulio, Bryone Jean Kuss, Stephen Mulligan
Journal: Blood (2015)
Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
Authors: Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A. Andrews, Paulina Stadnik, Agnel P. Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M. Huson, Thomas S. Jacques, Gregory James, Hannah Kondolf, Loshan Kangesu, Kim M. Keppler-Noreuil, Amjad Khan, Marjorie J. Lindhurst, Mark Lipson, Sahar Mansour, Justine O’Hara, Caroline Mahon, Anda Mosica, Celia Moss, Aditi Murthy, Juling Ong, Victoria E. Parker, Jean-Baptiste Rivière, Julie C. Sapp, Neil J. Sebire, Rahul Shah, Branavan Sivakumar, Anna Thomas, Alex Virasami, Regula Waelchli, Zhiqiang Zeng, Leslie G. Biesecker, Alex Barnacle, Maya Topf, Robert K. Semple, E. Elizabeth Patton, Veronica A. Kinsler
Journal: Journal of Clinical Investigation (2018)

Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels that lead to stroke, life-threatening bleeds, disfigurement, overgrowth, and/or pain. Therapeutic options are severely limited, and multidisciplinary management remains challenging, particularly for high-flow arteriovenous malformations (AVM).To investigate the pathogenesis of sporadic intracranial and extracranial VMs in 160 children in which known genetic causes had been excluded, we sequenced DNA from affected tissue and optimized analysis for detection of low mutant allele frequency.We discovered multiple mosaic-activating variants in 4 genes of the RAS/MAPK pathway, KRAS, NRAS, BRAF, and MAP2K1, a pathway commonly activated in cancer and responsible for the germline RAS-opathies. These variants were more frequent in high-flow than low-flow VMs. In vitro characterization and 2 transgenic zebrafish AVM models that recapitulated the human phenotype validated the pathogenesis of the mutant alleles. Importantly, treatment of AVM-BRAF mutant zebrafish with the BRAF inhibitor vemurafinib restored blood flow in AVM.Our findings uncover a major cause of sporadic VMs of different clinical types and thereby offer the potential of personalized medical treatment by repurposing existing licensed cancer therapies.This work was funded or supported by grants from the AVM Butterfly Charity, the Wellcome Trust (UK), the Medical Research Council (UK), the UK National Institute for Health Research, the L'Oreal-Melanoma Research Alliance, the European Research Council, and the National Human Genome Research Institute (US).
Intensive Glycemic Treatment During Type 1 Diabetes Pregnancy: A Story of (Mostly) Sweet Success!
Authors: Helen R. Murphy
Journal: Diabetes Care (2018)

Studies from Scotland and Canada confirm large increases in the incidence of pregnancies complicated by pregestational type 1 diabetes (T1D). With this increased antenatal workload comes more specialization and staff expertise, which may be important as diabetes technology use increases. While euglycemia remains elusive and obstetrical intervention (earlier delivery, increased operative deliveries) is increasing, there have been some notable successes in the past 5-10 years. These include a decline in the rates of congenital anomaly (Canada) and stillbirths (U.K.) and substantial reductions in both maternal hypoglycemia (both moderate and severe) across many countries. However, pregnant women with T1D still spend ∼30-45% of the time (8-11 h/day) hyperglycemic during the second and third trimesters. The duration of maternal hyperglycemia appears unchanged in routine clinical care over the past decade. This ongoing fetal exposure to maternal hyperglycemia likely explains the persistent rates of large for gestational age (LGA), neonatal hypoglycemia, and neonatal intensive care unit (NICU) admissions in T1D offspring. The Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT) found that pregnant women using real-time continuous glucose monitoring (CGM) spent 5% less time (1.2 h/day) hyperglycemic during the third trimester, with clinically relevant reductions in LGA, neonatal hypoglycemia, and NICU admissions. This article will review the progress in our understanding of the intensive glycemic treatment of T1D pregnancy, focusing in particular on the recent technological advances in CGM and automated insulin delivery. It suggests that even with advanced diabetes technology, optimal maternal dietary intake is needed to minimize the neonatal complications attributed to postprandial hyperglycemia.
Abstract 13585: Up Regulation of Autophagy in Hsp60 Mutant Heart is an Adaptive Response to Increased Oxidative Stress and Causes Cardiomyopathy
Authors: Hirokazu Enomoto, Shinji Makino, Nishant Mittal, Akinori Kimura, Takuro Arimura, Takeharu Hayashi, Takayuki Inomata, Keiichi Fukuda
Journal: Circulation (2014)

Introduction: Despite the recent advance of genetic studies, genetic causes of hereditary dilated cardiomyopathy (DCM) are still unknown in most cases. Heat shock protein 60 (Hsp60) is a well-known chaperonin, responsible for correct folding and transportation of cytoplasmic protein to mitochondria. This study is aimed to investigate whether dysfunction of Hsp60 leads to cardiomyopathy in a fish model. Methods: We previously developed a zebrafish mutant, nbl, which has a missense mutation in hsp60, leading to the loss of function. To evaluate the phenotype of cardiomyopathy in nbl, we performed RT-PCR, western blot and immunohistochemistry of the hearts. Results: Homozygous nbl embryos showed lower survival rate (65%), compared to 81% in wild-type (WT) embryos, when subjected to 33°C (stress condition). We observed pericardial edema in 92% of nbl homozygous mutants. Also, nbl homozygotes showed sudden death at around 8 months post fertilization (mpf), when grown in non-stress condition. At 8 mpf, nbl mutants showed dilated heart and high expression of reactive oxygen species (ROS). Both mRNA and protein levels of Hsp60 were similar in nbl homozygotes and WT, at 3 mpf but, much higher expression of Hsp60 in nbl homozygotes was observed at 6 mpf, beginning of death of nbl homozygous mutants. Electron microscopy analysis showed dark mitochondria, disrupted sarcomeric structure and higher number of autophagosomes in nbl homozygote hearts at 8 mpf. We, then, analyzed autophagy related genes and found that atg5, atg3 and gabarap mRNAs were increased in nbl homozygotes, suggesting the increased autophagy might underlie the pathogenesis of DCM. Furthermore, analysis of genetically unrelated patients with familial DCM, who had no mutations in the known DCM-causing genes, identified an hsp60 mutation in one DCM family in which two of four mutation prone individuals died suddenly. Over expression of nbl mutation or DCM-associated hsp60 mutation, but not normal hsp60, increased autophagosomes in Hela cells carrying GFP-LC3. Conclusions: Functional loss of Hsp60 increased oxidative stress in the heart, which leads to increased autophagy and confer the susceptibility to cardiomyopathy.
Predictors of accelerated decline in lung function in adult-onset asthma
Authors: Hanneke Coumou, Guus A. Westerhof, Selma B. de Nijs, Aeilko H. Zwinderman, Elisabeth H. Bel
Journal: European Respiratory Journal (2018)

Little is known about the prognosis of adults with new-onset asthma. Cross-sectional studies suggest that these patients may exhibit accelerated decline in forced expiratory volume in 1 s (FEV 1 ). However, risk factors for accelerated decline in lung function have not yet been identified. We aimed to identify these risk factors in a prospective 5-year follow-up study in 200 adults with newly diagnosed asthma. In the current study, clinical, functional and inflammatory parameters were assessed annually for 5 years. Linear mixed-effects models were used to identify predictors. Evaluable lung function sets of 141 patients were available. Median (interquartile range) change in post-bronchodilator FEV 1 was −17.5 (−54.2 to +22.4) mL per year. Accelerated decline in FEV 1 was defined by the lower quartile of decline (&gt;54.2 mL per year). Nasal polyps, number of blood and sputum eosinophils, body mass index, and level of exhaled nitric oxide were univariably associated with decline in lung function. Only the latter two were independently associated. Using cut-off values to identify patients at highest risk showed accelerated decline in FEV 1 in all patients with combined exhaled nitric oxide fraction ( F eNO ) ≥57 ppb and body mass index (BMI) ≤23 kg·m −2 . We conclude that adults with new-onset asthma with both high levels of exhaled nitric oxide and low BMI are at risk of accelerated decline in lung function.
Heart Failure Stimulates Tumor Growth by Circulating Factors
Authors: Wouter C. Meijers, Manuel Maglione, Stephan J.L. Bakker, Rupert Oberhuber, Lyanne M. Kieneker, Steven de Jong, Bernhard J. Haubner, Wouter B. Nagengast, Alexander R. Lyon, Bert van der Vegt, Dirk J. van Veldhuisen, B. Daan Westenbrink, Peter van der Meer, Herman H.W. Silljé, Rudolf A. de Boer
Journal: Circulation (2018)

Background: Heart failure (HF) survival has improved, and nowadays, many patients with HF die of noncardiac causes, including cancer. Our aim was to investigate whether a causal relationship exists between HF and the development of cancer. Methods: HF was induced by inflicting large anterior myocardial infarction in APC min mice, which are prone to developing precancerous intestinal tumors, and tumor growth was measured. In addition, to rule out hemodynamic impairment, a heterotopic heart transplantation model was used in which an infarcted or sham-operated heart was transplanted into a recipient mouse while the native heart was left in situ. After 6 weeks, tumor number, volume, and proliferation were quantified. Candidate secreted proteins were selected because they were previously associated both with (colon) tumor growth and with myocardial production in post–myocardial infarction proteomic studies. Myocardial gene expression levels of these selected candidates were analyzed, as well as their proliferative effects on HT-29 (colon cancer) cells. We validated these candidates by measuring them in plasma of healthy subjects and patients with HF. Finally, we associated the relation between cardiac specific and inflammatory biomarkers and new-onset cancer in a large, prospective general population cohort. Results: The presence of failing hearts, both native and heterotopically transplanted, resulted in significantly increased intestinal tumor load of 2.4-fold in APC min mice (all P &lt;0.0001). The severity of left ventricular dysfunction and fibrotic scar strongly correlated with tumor growth ( P =0.002 and P =0.016, respectively). We identified several proteins (including serpinA3 and A1, fibronectin, ceruloplasmin, and paraoxonase 1) that were elevated in human patients with chronic HF (n=101) compared with healthy subjects (n=180; P &lt;0.001). Functionally, serpinA3 resulted in marked proliferation effects in human colon cancer (HT-29) cells, associated with Akt-S6 phosphorylation. Finally, elevated cardiac and inflammation biomarkers in apparently healthy humans (n=8319) were predictive of new-onset cancer (n=1124) independently of risk factors for cancer (age, smoking status, and body mass index). Conclusions: We demonstrate that the presence of HF is associated with enhanced tumor growth and that this is independent of hemodynamic impairment and could be caused by cardiac excreted factors. A diagnosis of HF may therefore be considered a risk factor for incident cancer.
Abstract 18258: High-intensity Interval Training Improves Aerobic Capacity and Metabolic Risk Factors in Older Adults: A Randomized Controlled Trial
Authors: Chueh-Lung Hwang, Jeung-Ki Yoo, Han-Kyul Kim, Moon-Hyon Hwang, Eileen M Handberg, Demetra D Christou
Journal: Circulation (2015)

Introduction: Aging is associated with increased cardiovascular disease risk including reduced aerobic capacity and increased metabolic risk factors. Aerobic exercise training improves the risk for cardiovascular disease. The optimal exercise regimen for older adults, however, remains unknown. We tested the hypothesis that high-intensity interval training (HIIT) would be more effective than isocaloric moderate-intensity continuous training (MICT) in improving aerobic capacity and metabolic risks factors in older adults. Methods: Thirty eight sedentary older adults (age 65±1.0 yrs; mean±SE), free of cardiovascular disease, were randomly assigned to HIIT (n=13), MICT (n=13) or non-exercise control group (n=12). HIIT consisted of cycling at alternating intensities of 90 and 70% maximal heart rate for 40 minutes while MICT consisted of cycling at 70% maximal heart rate for 47 minutes. HIIT and MICT were performed on Airdyne bicycles, 4 days/week for 8 weeks, under supervision. Aerobic capacity was assessed by peak oxygen consumption during an incremental treadmill test. Metabolic risk factors included fasting lipid profile, glucose, insulin, and insulin resistance (homeostasis model assessment; HOMA-IR). Body composition was assessed using dual-energy x-ray absorptiometry. All measures were obtained at baseline and following the intervention. Results: Peak oxygen consumption increased by 2.8 ml/kg/min (23.0±1.6 vs. 25.7±1.5, pre- vs. post-intervention; P &lt;0.05) in HIIT, but did not change in MICT and control group (26.0±1.5 vs. 26.2±1.4 and 23.5±1.4 vs. 24.0±1.4, respectively; P &gt;0.05). Insulin and HOMA-IR improved only in HIIT (-1.9±0.6μU/ml and -0.42±0.16, P &lt;0.05; respectively) and these changes were negatively associated with the change in peak oxygen consumption (r=-0.37, P &lt;0.05 for both). Overall, lipids, body weight, body fat, and fat-free mass did not change in response to the intervention in any of the groups (P&gt;0.05). Conclusions: HIIT but not MICT improves aerobic capacity and glucose control in healthy older adults without affecting lipids or body composition.