tbuckley/cabot-search huggingface dataset:
Expérience de quatre années de section endoscopique par plasma argon de prothèses métalliques biliaires et digestives
Authors: G Vanbiervliet, JF Demarquay, X Hébuterne
Journal: Endoscopy (2004)

But: Nous avons précédemment décrit notre expérience dans l’utilisation du plasma argon pour la section des prothèses métalliques biliaires responsables de complications duodénales (hémorragie, perforation) [1]. Le but de cette étude était d’évaluer cette technique sur différents types d’endoprothèses métalliques auto-expansibles, en différents sites de pose et de la confronter aux nouvelles complications rencontrées par l’endoscopiste et le clinicien (obstruction secondaire tumorale ou non, migration, douleurs, hémorragies et perforation tardive). Patients et Méthodes: De janvier 2000 à août 2003, 22 patients ont bénéficié de section par plasma argon de prothèses métalliques dans notre unité d’endoscopie. Il s’agissait de 10 femmes (45%) et de 12 hommes (55%) (âge moyen 70,5 ans; extrêmes 46–96 ans). Une prothèse métallique biliaire Wallstent Unistep® non couverte (Boston Scientific, Ireland) en acier était en place chez 17 patients (pour 9 cancers de la tête pancréatique, 4 ampullomes, 3 cancers biliaires et une pancréatite chronique), une prothèse métallique biliaire couverte Wallstent Permalune® chez un patient (pour un cancer de la tête pancréatique), une prothèse digestive non couverte Enteral Wallstent® pyloro duodénale chez 2-malades [pour un cancer pancréatique et une carcinose péritonéale] et une endoprothèse Bard Memotherm® recto colique non couverte (Bard S.A, France) en nitinol chez 2 patients [pour cancers recto coliques sténosant]. La section par fulguration (80 W, 0.8 L/min) était effectuée sous anesthésie générale par Propofol®. Résultats: La section avec raccourcissement prothétique, était réalisée avec succès et sans complication immédiate ou retardée (suivi médian 15,8 mois; extrêmes 1–43) pour 8 patients de manière préventive (risque de lésion des muqueuses à proximité ou d’obstruction digestive secondaire), pour 6-malades présentant des ulcérations duodénales ou coliques avec 2 cas d’hémorragie, entraînant la disparition totale des lésions. Le traitement permettait l’accès au cholédoque pour 6 patients par désobstruction de la lumière duodénale (prothèse biliaire migrée, malpositionnée) et calmait significativement le ténesme rectal d’un patient (prothèse rectale impactée). Le seul échec était observé pour la prothèse biliaire couverte, la membrane en polyuréthane ne permettant pas la conduction du courant de section. Conclusion: Cette étude met en évidence la faisabilité, l’efficacité et l’innocuité de la section endoscopique par plasma argon des prothèses digestives et biliaires métalliques, en acier et en nitinol, non couvertes. La grande maniabilité de cette technique, sa disponibilité et son faible coût, nous font recommander cette approche endoscopique thérapeutique.
Concurrent and sequential initiation of ovarian function suppression with chemotherapy in premenopausal women with endocrine-responsive early breast cancer: an exploratory analysis of TEXT and SOFT
Authors: M.M. Regan, B.A. Walley, P.A. Francis, G.F. Fleming, I. Láng, H.L. Gómez, M. Colleoni, C. Tondini, G. Pinotti, M. Salim, S. Spazzapan, V. Parmar, T. Ruhstaller, E.A. Abdi, R.D. Gelber, A.S. Coates, A. Goldhirsch, O. Pagani
Journal: Annals of Oncology (2017)

BackgroundRecent breast cancer treatment guidelines recommend that higher-risk premenopausal patients should receive ovarian function suppression (OFS) as part of adjuvant endocrine therapy. If chemotherapy is also given, it is uncertain whether to select concurrent or sequential OFS initiation.Design and methodsWe analyzed 1872 patients enrolled in the randomized phase III TEXT and SOFT trials who received adjuvant chemotherapy for hormone receptor-positive, HER2-negative breast cancer and upon randomization to an OFS-containing adjuvant endocrine therapy, initiated gonadotropin-releasing-hormone-agonist triptorelin. Breast cancer-free interval (BCFI) was compared between patients who received OFS concurrently with chemotherapy in TEXT (n = 1242) versus sequentially post-chemotherapy in SOFT (n = 630). Because timing of trial enrollment relative to adjuvant chemotherapy differed, we implemented landmark analysis re-defining BCFI beginning 1 year after final dose of chemotherapy (median, 15.5 and 8.1 months from enrollment to landmark in TEXT and SOFT, respectively). As a non-randomized treatment comparison, we implemented comparative-effectiveness propensity score methodology with weighted Cox modeling.ResultsDistributions of several clinico-pathologic characteristics differed between groups. Patients who were premenopausal post-chemotherapy in SOFT were younger on average. The median duration of adjuvant chemotherapy was 18 weeks in both groups. There were 231 (12%) BC events after post-landmark median follow-up of about 5 years. Concurrent use of triptorelin with chemotherapy was not associated with a significant difference in post-landmark BCFI compared with sequential triptorelin post-chemotherapy, either in the overall population (HR = 1.11, 95% CI 0.72–1.72; P = 0.72; 4-year BCFI 89% in both groups), or in the subgroup of 692 women <40 years at diagnosis (HR = 1.13, 95% CI 0.69–1.84) who are less likely to develop chemotherapy-induced amenorrhea.ConclusionBased on comparative-effectiveness modeling of TEXT and SOFT after about 5 years median follow-up, with limited statistical power especially for the subgroup <40 years, neither detrimental nor beneficial effect of concurrent administration of OFS with chemotherapy on the efficacy of adjuvant therapy that includes chemotherapy was detected.Clinicaltrials.govNCT00066690 and NCT00066703.
Shared Understanding With Patients
Authors: Neal Maskrey, Andrea Gordon
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
06.11 Anti-tnf-α vaccination protects from experimental arthritis without negatively affecting resistance to mycobacterium tuberculosis infection
Authors: Eric Assier, Nadia Belmellat, Luca Semerano, Bernhard Ryffel, Patrice Decker, Valérie Quesniaux, Marie-Christophe Boissier
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> TNF-α-blocking therapy is a successful treatment strategy for rheumatoid arthritis (RA), but is associated with reduced resistance to tuberculosis. We have developed a vaccine against mouse TNF-α (TNF-KLH) which protects mice from collagen-induced arthritis (CIA) and collagen-antibodies-induced arthritis (CAIA). We aimed at modelizing the infectious risk/benefit ratio of TNF-α neutralisation by comparing different strategies of TNF-α targeting in experimental <i>Mycobacterium tuberculosis</i> infection. <h3>Materials and methods</h3> 4 groups (TNF-KLH, etanercept, KLH, PBS) of 10 C57BL/6 mice were compared with TNF deficient mice (TNF -/-). Vaccines were emulsified in IFA before i.m. administration (days −44, –31, −17 and −4). Other treatments were given from D0. All groups were infected at day 0 by 10<sup>4</sup> cfu of <i>Mycobacterium tuberculosis</i> (H37Rv virulent strain). Mouse groups were divided in two arms: one was euthanized 28 days post-infection, the lasting mice were euthanized 56 days post-infection. Bacterial burden was evaluated in lungs. Cellular infiltration was studied by immunohistological analysis. <h3>Results</h3> A sustained anti-TNF-α antibody production was obtained in vaccinated mice. At day 28 of Mycobacteria infection, bacterial burden, organ weights, neutrophils and B cells infiltration were similar between TNF-KLH, KLH and PBS groups. At this time point, histological analysis showed higher surface of granuloma in liver of etanercept and TNF-/- groups than TNF-KLH group. At day 56 post infection, etanercept group presented higher surface of liver and lung granuloma than TNF-KLH and KLH groups. These observations were in accordance with a progression of the disease in etanercept group, whereas such effect was not retrieved in TNF-KLH and immunocompetent groups (KLH, PBS). <h3>Conclusion</h3> Our results indicate that anti-TNF-α vaccination could protect mice from inflammatory arthritis without deeply altering host immunity against infection, suggesting the existence of two distinct pathophysiologic thresholds for TNF-α inhibition, one for arthritis improvement, the other for infection facilitation. These thresholds might be dependend on the TNF inhibition strategy.
Safety and efficacy of a fixed-dose combination regimen of grazoprevir, ruzasvir, and uprifosbuvir with or without ribavirin in participants with and without cirrhosis with chronic hepatitis C virus genotype 1, 2, or 3 infection (C-CREST-1 and C-CREST-2, part B): two randomised, phase 2, open-label trials
Authors: Eric Lawitz, Maria Buti, John M Vierling, Piero L Almasio, Savino Bruno, Peter J Ruane, Tarek I Hassanein, Beat Muellhaupt, Brian Pearlman, Ligita Jancoriene, Wei Gao, Hsueh-Cheng Huang, Aimee Shepherd, Brynne Tannenbaum, Doreen Fernsler, Jerry J Li, Anjana Grandhi, Hong Liu, Feng-Hsiu Su, Shuyan Wan, Frank J Dutko, Bach-Yen T Nguyen, Janice Wahl, Michael N Robertson, Eliav Barr, Wendy W Yeh, Rebeca M Plank, Joan R Butterton, Eric M Yoshida
Journal: The Lancet. Gastroenterology & hepatology (2017)
Human Perinatal‐Derived Biomaterials
Authors: Marc C. Moore, Aurore Van De Walle, Jerry Chang, Cassandra Juran, Peter S. McFetridge
Journal: Advanced Healthcare Materials (2017)

Human perinatal tissues have been used for over a century as allogeneic biomaterials. Due to their advantageous properties including angiogenecity, anti-inflammation, anti-microbial, and immune privilege, these tissues are being utilized for novel applications across wide-ranging medical disciplines. Given continued clinical success, increased adoption of perinatal tissues as a disruptive technology platform has allowed for significant penetration into the multi-billion dollar biologics market. Here, we review current progress and future applications of perinatal biomaterials, as well as associated regulatory issues.
Silicone‐Based Adhesives with Highly Tunable Adhesion Force for Skin‐Contact Applications
Authors: Bong Kuk Lee, Jin Hwa Ryu, In‐Bok Baek, Yarkyeon Kim, Won Ick Jang, Sang‐Hyeob Kim, Yong Sun Yoon, Seung Hwan Kim, Seong‐Gu Hong, Sangwon Byun, Han Young Yu
Journal: Advanced Healthcare Materials (2017)

Abstract A fundamental approach to fabricating silicone‐based adhesives with highly tunable adhesion force for the skin‐contact applications is presented. Liquid blends consisting of vinyl‐multifunctional polydimethylsiloxane (V‐PDMS), hydride‐terminated PDMS (H‐PDMS), and a tackifier composed of a silanol‐terminated PDMS/MQ resin mixture and the MQ resin are used as the adhesive materials. The peel adhesion force of addition‐cured adhesives on the skin is increased by increasing the H‐PDMS molecular weights and the tackifier content, and decreasing the H‐PDMS/V‐PDMS ratio. There is an inverse relationship between the adhesion force and the Young's modulus. The low‐modulus adhesives with a low H‐PDMS/V‐PDMS ratio exhibit enhanced adhesion properties. The low‐modulus adhesives with the high MQ resin content show significantly enhanced adhesion properties. These adhesives exhibit a wide range of modulus (2–499 kPa), and their adhesion force (0.04–5.38 N) is superior to commercially available soft silicone adhesives (0.82–2.79 N). The strong adhesives (&gt;≈2 N) provide sufficient adhesion for fixing the flexible electrocardiogram (ECG) device to the skin in most daily activity. The human ECG signals are successfully recorded in real time. These results suggest that the silicone‐based adhesives should be useful as an atraumatic adhesive for the skin‐contact applications.
Comorbidity and other predictors of survival in veterans with colorectal cancer (CRC) at different stages.
Authors: Fengming Zhong, Ying Margie Tang, Victor Tsu-Shih Chang, Neal Patel, Nneoma Olivia Okoronkwo, Melanie L. Gonzalez, Trent P Wang, Tanganyika Barnes, Emma R Paz-Querubin, Basil Kasimis
Journal: Journal of Clinical Oncology (2013)

e14625 Background: We analyzed comorbidity and other predictors of survival for patients (pts) with different stages of CRC. Methods: In an IRB-approved protocol, we reviewed the records of pts diagnosed with CRC at a VA medical center from 01/01/2003 to 12/31/2011 for demographics, stage, grade, ECOG performance status (PS), CEA, Hemoglobin (HGB), and Albumin (ALB) at diagnosis (dx). Comorbidity was assessed with the Charlson Comorbidity Index (CCI), the Cumulative Illness Rating Scales (CIRS), and the Kaplan-Feinstein Index (KFI). Statistical analyses were performed with SAS 9.2/Stata 11.0. We compared the pts with curative stage (0-III) vs late stage (IV) CRC. Results: There were 279 men. 156 pts (55.9%) were Caucasians, 106 pts (38%) African Americans, 15 pts (5.4%) Hispanics, and 2 pts (0.7%) Asians. The median (M) age at dx was 70 (45-90) years. 132 pts (47.3%) were deceased. 209 pts were curative stage at dx, 54 pts late stage and 16 pts unknown stage. Age and race were not different between the two stage groups. The late group had higher histological grades (P&lt;0.001). In univariate analysis, age, stage, grade, ECOG PS, HGB, ALB, CCI, CIRS16, CIRS 17, CIRS 19, and KFI are significant predictors of survival for all stage pts. Significant predictors for curative stage pts are age, ECOG PS, HGB, CCI, CIRS16, CIRS17, and CIRS 18, and for late stage pts are grade, ECOG PS, ALB, and CCI. Significant factors by multivariate analysis are summarized in the table. Conclusions: These findings from this larger population confirm our earlier findings (ASCO 2012 e14125). Grade, stage, ECOG PS, and CIRS 19 (very severe comorbidity) are important independent survival predictors for veterans with CRC. Independent predictors for curative stage pts are ECOG PS and CIRS 16 (comorbidity severity summary score), and for late stage pts are ALB, CCI and CIRS 19. The late stage pts had higher grades. Further studies are needed to confirm this observation. Supported by NJCCR. [Table: see text]
Jab1/CSN5 mediates protein degradation of the Rad9/Rad1/Hus1 complex
Authors: Jin Huang, Chongyuan Lu, Xu Cao, Mei Wan
Journal: Cancer Research (2007)

1101   Instability of the genome in cells is an important contributor to heritable and somatic genetic changes that drive tumorigenic processes. To ensure the stability of their genomes, cells activate checkpoint signaling pathways in response to DNA damage and replication stress. The Rad1-Rad9-Hus1 (9-1-1) complex serves a dual role as a DNA-damage sensor in checkpoint signaling and as a mediator and platform for DNA repair. However, the intercellular mechanisms that regulate 9-1-1 complex level in mammalian cells are poorly understood. Jab1/CSN5, the fifth component of the COP9 signalosome complex, plays a central role in the degradation of multiple proteins in mammalian cells and is emerging as an important regulator in cancer development. Here we tested the hypothesis that Jab1/CSN5, regulates of the degradation of the 9-1-1 complex via the 26S proteosome pathway. We demonstrated that overexpression of Jab1/CSN5 enhanced chromosomal aberration and gene mutation rate in cells. We also provide evidence that Jab1 physically associates with the 9-1-1 complex. This association is mediated through direct interaction between Jab1 and Rad1. Jab1/CSN5 causes the translocation of the 9-1-1 complex from the nucleus to the cytoplasm, mediating rapid degradation of the 9-1-1 complex via the ubiquitin-proteasome pathway. The interaction of Jab1 with 9-1-1 complex is enhanced by UV exposure and hydroxyurea treatment, and the degradation of 9-1-1 complex by Jab1/CSN5 is increased significant under these replication stresses. These results indicate that Jab1/CSN5 is an important regulator for 9-1-1 complex stability control in cells, and may provide a novel mechanism underlying Jab1/CSN5-associated tumorigenesis.
Physical activity during adolescence and the development of cam morphology: a cross-sectional cohort study of 210 individuals
Authors: Antony Palmer, Scott Fernquest, Mo Gimpel, Richard Birchall, Andrew Judge, John Broomfield, Julia Newton, Mark Wotherspoon, Andrew Carr, Sion Glyn-Jones
Journal: British Journal of Sports Medicine (2017)

Introduction Cam morphology is a strong risk factor for the development of hip pain and osteoarthritis. It is increasingly thought to develop in association with intense physical activity during youth; however, the aetiology remains uncertain. The study aim was to characterise the effect of physical activity on morphological hip development during adolescence. Methods Cross-sectional study of individuals aged 9–18 years recruited from Southampton Football Club Academy (103 male) with an age-matched control population (52 males and 55 females). Assessments included questionnaires and 3 Tesla MRI of both hips. Alpha angle, epiphyseal extension and epiphyseal tilt were measured on radial images. Results Alpha angle and epiphyseal extension increased most rapidly between ages 12 and 14 years. Soft-tissue hypertrophy at the femoral head-neck junction preceded osseous cam morphology and was first evident at age 10 years. The greatest increase and highest absolute values of alpha angle and epiphyseal extension were colocalised at 1 o’clock. Maximum alpha angles were 6.7 degrees greater in males than females (p=0.005). Compared with individuals who play no regular sport, alpha angles were 4.0 degrees higher in individuals who play sport for a school or club (p=0.041) and 7.7 degrees higher in individuals competing at a national or international level (p=0.035). There was no association with leg dominance . Conclusions Sporting activity during adolescence is strongly associated with the development of cam morphology secondary to epiphyseal hypertrophy and extension with a dose-response relationship. Males participating in competitive sport are at particularly elevated risk of developing cam morphology and secondary hip pathology.
Prevalence and treatment outcome of extensively drug-resistant tuberculosis plus additional drug resistance from the National Clinical Center for Tuberculosis in China: A five-year review
Authors: Yu Pang, Jie Lu, Fengmin Huo, Yifeng Ma, Liping Zhao, Yunxu Li, Qian Liang, Naihui Chu, Mengqiu Gao, Hairong Huang
Journal: Journal of Infection (2017)
Relevance of Spatial Heterogeneity of Immune Infiltration for Predicting Risk of Recurrence After Endocrine Therapy of ER+ Breast Cancer
Authors: Andreas Heindl, Ivana Sestak, Kalnisha Naidoo, Jack Cuzick, Mitchell Dowsett, Yinyin Yuan
Journal: JNCI Journal of the National Cancer Institute (2017)

Despite increasing evidence supporting the clinical utility of immune infiltration in the estrogen receptor-negative (ER-) subtype, the prognostic value of immune infiltration for ER+ disease is not well defined.
INJURY PREVENTION IN YOUNG ATHLETES: INFLUENCE OF PREVENTION-SUPERVISION ON COMPLIANCE
Authors: Josefine Stoll, Juliane Mueller, Steffen Mueller, Michael Cassel, Frank Mayer
Journal: British Journal of Sports Medicine (2017)

Background Prevention programs are reducing the risk of injuries. The success of these programs is dependent on a high compliance. However, it is unclear which kind of supervision lead to a high compliance in young athletes. Objective To compare the influence of different kinds of prevention-supervision during prevention training on compliance in young athletes. Design Controlled trial. Setting University Potsdam, Medical Examination Center of the German Olympic Sports Federation. Patients (or Participants) 173 young athletes (m/f: 108/68; 13.4±0.4 yrs, 164.±58.6 cm, 52.3±9.0 kg) from different sports were included. Interventions (or Assessment of Risk Factors) Athletes participated in a back pain prevention program (duration: 45 weeks; 4 exercises, 3 times/week, progression every 15 weeks). Following the initial introduction to the program, athletes were divided into 3 groups (G1: N=30; G2: N=54; G3: N=89). In G1 the coach, in G2 the coach and the athlete was responsible to execute the prevention program. In addition to G2, a therapist supervised the program once per week in G3. The number of prevention sessions was documented (paper &amp; pencil) by coach (G1), athlete (G2) and athlete/therapist (G3). Main Outcome Measurements The number of response per athlete (documented sessions) and the training-sessions per week was analysed. Data are presented descriptively followed by analysis of group differences (ANOVA; post-hoc Tukey, α =0.05). Results All athletes in G1 responded and documented the training-session/week with a frequency of 2.0±0.4 sessions/week. In G2 53 athletes (2.5±0.7 sessions/week) and in G3 75 athletes (2.7±0.8 sessions/week) responded. Statistically significant differences could be shown between G1 and G2 (p=0.0005) and between G1 and G3 (p=0.058). There were no group differences between G2 and G3 (p=0.15). Conclusions For a targeted high compliance in prevention training, a supervised implementation seems necessary. Good teamwork between coach, athlete and therapist seems to be mandatory. A personal responsibility of the athlete is relevant.
A statistical framework for analyzing deep mutational scanning data
Authors: Alan F. Rubin, Hannah Gelman, Nathan Lucas, Sandra M. Bajjalieh, Anthony T. Papenfuss, Terence P. Speed, Douglas M. Fowler
Journal: Genome biology (2017)

Deep mutational scanning is a widely used method for multiplex measurement of functional consequences of protein variants. We developed a new deep mutational scanning statistical model that generates error estimates for each measurement, capturing both sampling error and consistency between replicates. We apply our model to one novel and five published datasets comprising 243,732 variants and demonstrate its superiority in removing noisy variants and conducting hypothesis testing. Simulations show our model applies to scans based on cell growth or binding and handles common experimental errors. We implemented our model in Enrich2, software that can empower researchers analyzing deep mutational scanning data.
抗体10-1074はHIV-1感染者でウイルス血症を抑制する
Authors: Caskey Marina, Schoofs Till, Settler Allison, Karagounis Theodora, Nogueira Lilian, Oliveira Thiago Y, Cohen Yehuda Z, Shimeliovich Irina, Unson‐O’Brien Cecilia, Levin Rebeka, Witmer‐Pack Maggi, Schlesinger Sarah J, Nussenzweig Michel C, Gruell Henning, Weiland Daniela, Klein Florian, Lehmann Clara, Gillor Daniel, Kuemmerle Tim, Wyen Christoph, Faetkenheuer Gerd, Kreider Edward F, Learn Gerald H, Hahn Beatrice H, Murrell Ben, Ignacio Caroline, Pfeifer Nico, Robles Alexander, Seaman Michael S, Eren Kemal, Kiss Szilard, West Anthony P, Bjorkman Pamela J, Mouquet Hugo, Zingman Barry S, Gulick Roy M, Keler Tibor
Journal: Nature Medicine (2017)
腫瘍標的超音波撮像と超音波誘発薬剤送達のための化学的ガス発生ナノ粒子【Powered by NICT】
Authors: Min Hyun Su, Son Sejin, You Dong Gil, Lee Tae Woong, Lee Jangwook, Lee Sangmin, Yhee Ji Young, Lee Jaeyoung, Han Moon Hee, Park Jae Hyung, Kim Sun Hwa, Choi Kuiwon, Park Kinam, Kim Kwangmeyung, Kwon Ick Chan
Journal: Biomaterials (2016)