tbuckley/cabot-search huggingface dataset:
NO RELATIONSHIP BETWEEN FLOOR TYPE AND MATCH INJURY PATTERNS IN GERMAN MEN'S PROFESSIONAL HANDBALL
Authors: Thomas Henke, Patrick Luig
Journal: British Journal of Sports Medicine (2017)

Background Injuries are likely to negatively affect both individual and team performance in German men's professional handball. The influence of different floor types on injury patterns has not been clearly established. Objective Analysis of match injury frequency and patterns in relation to floor types. Design Prospective observational cohort study. Setting Two highest German professional leagues in men's handball. Participants All first and second league handball players (n=818) of the 2014–2015 season. Assessment of Risk Factors Analysis of all injuries of these players that were registered by clubs or physicians with the VBG (German statutory accident insurance for the administrative sector) as part of the occupational accident reporting and that either led to the player's short-term disability (time-loss) and/or to medical treatment costs (medical-attention). Main Outcome Measurements Injury prevalence, injury incidence, injured body parts, type of injury, short-term disability. Results 641 of the 818 observed players (78.4%) were injured. In total 1,988 injuries were recorded. Of these, 798 injuries occurred during competitive match play (40.1%). The overall match incidence was 71.2 injuries/1,000 h. 51.0% of competitive matches were played on PVC, 36.0% on wood and 13.0% on linoleum. The injury incidences for these three floor types did not differ significantly (PVC: 67.4/1,000 h, linoleum: 73.4/1,000 h, wood: 72.8/1,000 h). Moreover, no significant difference was observed for injured body region, severity of injury or playing position with regard to the floor type. However, there were trends toward significance for very severe injuries (&gt;90 days time-loss) on PVC floors and goalkeeper injuries on linoleum floors. Conclusions There seems to be no direct relationship between floor types used in the two highest German men's handball leagues and match injury patterns. Further studies should eventually pay more attention to the floor conditions in handball arenas, especially in view of resin use, rather than to the floor type.
The total heart beats per 24 hours by ambulatory electrocardiography and the changes of heart rate by treadmill exercise test in sick sinus syndrome.
Authors: Akihiko Shimizu, Masahiko Fukatani, Kowei Kitano, Muneo Tanigawa, Chiaki Ueyama, Fumihiro Kiya, Katsusuke Yano, Kunitake. Hashiba
Journal: Circulation (1988)

To study the clinical implications of the total number of heart beats per 24 hours (THB), 24 hour ambulatory electrocardiography and treadmill test were performed by sixty patients with sick sinus syndrome (SSS, 58 +/- 12 years old) who underwent overdrive suppression test. Results were compared with thirty control subjects (58 +/- 12 years old). The THB was 74 +/- 11 thousand beats in the SSS group and 99 +/- 10 thousand beats in the control group. The THB and the maximal heart rate (MHR) achieved during the treadmill test were significantly lower in the SSS group than in the control group. However, the exercise duration in patients with SSS was similar to that of the control subjects. The exercise duration and the MHR were correlated to age, but not to the THB in the patients with SSS. There was no significant relationship between the total heart beats per 24 hours and the maximal sinus node recovery time (max. SNRT). We conclude that the THB, independent of the max. SNRT, can be a useful index in diagnosing and assessing the quantity of bradycardia in patients with SSS. The tolerance of exercise and the MHR were not correlated with the THB, in patients with SSS.
HIGH PREVALENCE AND INCIDENCE OF HEALTH PROBLEMS IN TALENTED DUTCH ATHLETES
Authors: Angelo Richardson, Ben Clarsen, Evert Verhagen, Janine Stubbe
Journal: British Journal of Sports Medicine (2017)

Background A thorough knowledge of the epidemiology of health problems in youth female elite sports is lacking, as most studies define health problems as time loss from participation. Objective To prospective investigate the burden of health problems in young female elite athletes. Design Descriptive epidemiology study. Setting Participants were involved in the Dutch national high-performance program of the Centre for Top sport and Education Amsterdam, the Netherlands. Patients (or Participants) Sixty young elite Dutch female athletes (mean age 16.6; SD=2.3 years) participating in soccer (N=23), basketball (N=22) and gymnastic (N=15) were prospectively followed during one competitive season. All athletes completed the study. Interventions (or Assessment of Risk Factors) During the pre-season period, age, height and body weight was recorded. To collect health problem data, all athletes were asked to complete the Oslo Sports Trauma Research Center Questionnaire on Health Problems every other week during the entire season. Main Outcome Measurements The prevalence and incidence density of all health problems was calculated. To calculate the relative impact of injuries between the various sporting groups, a cumulative severity score was calculated for each anatomical area. Results At any given time 47.9% of the athletes had an injury (95% CI 43.6% to 52.6%). The average injury incidence density was 8.6 per 1000 hours of athlete exposure. The average number of reported injuries per athlete per season was significantly higher in soccer athletes (4.3±2.7) than in basketball athletes (2.6±2.0) (p=0.03). Injuries located at the knee in basketball and soccer and injuries located at the heel in the gymnastic squad had the highest impact on sports participation. Conclusions The new injury methodology captured a more complete picture of the burden of health complaints in the athletes, in contrasts to what is found using standard surveillance methods.
New Painful Nodules in a Patient With Multiple Myeloma
Authors: Edison W. Tsui, Eunjung Choi, Kenneth R. Meehan
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abstract 263: Enhance Cd34+ Cell Therapy For Limb Ischemia Using Novel Bioactive Peptide Amphiphiles Nanofibers
Authors: Yang Yu, Eduard Sleep, Junlan Zhou, Douglas W Losordo, Samuel I Stupp, Gangjian Qin
Journal: Circulation Research (2014)

Background: CD34+ cells have shown unprecedented promise for ischemic tissue repair in recent clinical trials; however, their recruitment, retention, and survival in the injured tissue remain one of the major barriers to the success of this novel therapeutic strategy. Methods and Results: In this study, we have developed a self-assembling bioactive peptide amphiphile (PA) nanofiber that displays the integrin-recognized cell adhesion epitope RGDS and tested this novel scaffold material for therapeutic delivery, retention, and functional support of human CD34+ cells in a mouse model of critical hind-limb ischemia (CLI). In culture, PA nanofibers, but not non-bioactive nanostructures or nanostructures with scrambled DGRS epitope, significantly enhanced the adhesion and survival of human CD34+ cells under a number of cellular stresses. In CLI nude mice, intramuscular injection of human CD34+ cells contained in the RGDS nanostructures led to a significantly better blood perfusion, motor ability, limb salvage, and treadmill endurance when compared with those of CD34+ cells contained in DGRS nanostructures, cells alone or RGDS alone. Histology analyses revealed a better viability and retention of CD34+ cells in the limb tissue of the RGDS nanostructures/CD34+ cells group than in the RGDS nanostructures alone or cells alone group. In consistent with the improved functional recovery, the density of capillaries in the ischemic limb of RGDS nanostructures/CD34+ cells group was significantly greater than in other groups. Conclusions: Our data demonstrate that integrin-specific binding epitope RGDS nanostructure enhances viability, adhesion, and angiogenic capability of human CD34+ cells. This pre-clinical study provides a rationale for further investigation of combining RGDS PAs with human CD34+ cells to enhance the effectiveness of cell therapy for ischemic limb disease.
Unexpected Fibrosing Mediastinitis Shown on FDG PET/CT in a Patient With IgG4-Related Disease
Authors: Ying Kan, Leilei Yuan, Wei Wang, Jigang Yang
Journal: Clinical Nuclear Medicine (2017)

A 66-year-old man presented to our hospital because of abdominal pain for 5 days. A contrast abdominal CT raised the possibility of pancreatic carcinoma. FDG PET/CT showed increased FDG accumulation not only in the pancreas and the retroperitoneum, but also in the posterior mediastinum, which was not typical of pancreatic carcinoma. The patient was subsequently diagnosed having immunoglobulin G4-related disease following the histopathologic examination.
GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder
Authors: Robert C. Young, Benoit H. Mulsant, Martha Sajatovic, Ariel G. Gildengers, Laszlo Gyulai, Rayan K. Al Jurdi, John Beyer, Jovier Evans, Samprit Banerjee, Rebecca Greenberg, Patricia Marino, Mark E. Kunik, Peijun Chen, Marna Barrett, Herbert C. Schulberg, Martha L. Bruce, Charles F. Reynolds, George S. Alexopoulos, Laura D. Evans, Sibel Klimstra, Nabil Kotbi, Michelle Gabriele, Christine Jacobson, Joseph Kwentus, Lauren Marangell, Kristin Cassidy, Philipp Dines, Luis Ramirez, Michael Thase, Bijan Etemad, Ruben Gur, Paul Moberg, David Oslin, Joel Streim, Thomas TenHave, David Weiss, Patrick Connelly, Tracey Holsinger, K.R.R. Krishnan, Mike Mani, Jody Miller, Richard Weisler, James Emanuel, Adriana Hyams, Dielle Miranda, Bruce Pollock, Tarek K. Rajii, Kari Seals, Ellen Whyte, Elizabeth Zachariah
Journal: American Journal of Psychiatry (2017)

Clinicians treating older patients with bipolar disorder with mood stabilizers need evidence from age-specific randomized controlled trials. The authors describe findings from a first such study of late-life mania.The authors compared the tolerability and efficacy of lithium carbonate and divalproex in 224 inpatients and outpatients age 60 or older with bipolar I disorder who presented with a manic, hypomanic, or mixed episode. Participants were randomly assigned, under double-blind conditions, to treatment with lithium (target serum concentration, 0.80-0.99 mEq/L) or divalproex (target serum valproate concentration, 80-99 μg/mL) for 9 weeks. Participants with an inadequate response after 3 weeks received open adjunctive risperidone. The authors hypothesized that divalproex would be better tolerated and more efficacious than lithium. Tolerability was assessed based on a measure of sedation and on the proportions of participants achieving target concentrations. Efficacy was assessed with the Young Mania Rating Scale (YMRS).Attrition rates were similar for lithium and divalproex (14% and 18% at week 3 and 51% and 44% at week 9, respectively). The groups did not differ significantly in sedation. Participants in the lithium group tended to experience more tremor. Similar proportions of participants in the lithium and divalproex groups achieved target concentrations (57% and 56%, respectively). A longitudinal mixed model of improvement (change from baseline in YMRS score) favored lithium (change in score, 3.90; 97.5% CI=1.71, 6.09). Nine-week response rates did not differ significantly between the lithium and divalproex groups (79% and 73%, respectively). The need for adjunctive risperidone was low and similar between groups (17% and 14%, respectively).Both lithium and divalproex were adequately tolerated and efficacious; lithium was associated with a greater reduction in mania scores over 9 weeks.
The Identification of Therapeutic Targets in Lung Cancer Based on Transcriptomic and Proteomic Characterization of Cancer-Testis Antigens
Authors: Dijana Djureinovic, Björn Hallström, Johanna Sofia Margareta Mattsson, Linnea La Fleur, Johan Botling, Linn Fagerberg, Hans Brunnstrom, Simon Ekman, Elisabeth Stahle, Hirsh Koyi, Mats Lambe, Eva Branden, Cecilia Lindskog, Fredrik Ponten, Mathias Uhlen, Patrick Micke
Journal: Journal of Thoracic Oncology (2015)
THU0213 Comparative efficacy and safety of baricitinib 2 MG and 4 MG in patients with active rheumatoid arthritis: a bayesian network meta-analysis of randomized controlled trials
Authors: YH Lee, YH Seo, GG Song
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Baricitinib is a potent, selective JAK1 and JAK2 inhibitor. Baricitinib has been investigated in phase II and phase III studies of active patients with rheumatoid arthritis (RA). who showed an inadequate response to disease-modifying antirheumatic drugs (DMARDs), including methotrexate (MTX) and biologics. However, due to the lack of adequate multiple comparisons, the comparative efficacy and safety of baricitinib in various treatment regimens with different dosages or in combination with DMARDs or MTX remains unclear. <h3>Objectives</h3> This study aimed to assess the relative efficacy and safety of once-daily baricitinib 2 mg and 4 mg administration in patients with active RA. <h3>Methods</h3> We performed a literature search using MEDLINE, EMBASE, the Cochrane Controlled Trials Register, and the EULAR and ACR conference proceedings. In this network meta-analysis, randomized controlled trials (RCTs) examining the efficacy and safety of baricitinib in patients with active RA were included. A Bayesian network meta-analysis was conducted to combine the direct and indirect evidence from the RCTs. <h3>Results</h3> Seven RCTs involving 3,461 patients met the inclusion criteria. There were 10 pairwise comparisons, including 7 direct comparisons and 5 interventions. The ACR20 response rate was significantly higher in the baricitinib 4 mg in combination with disease-modifying antirheumatic drugs (DMARD) group than in the placebo+DMARD group (OR 3.13, 95% CrI 2.32–4.33). Compared with the placebo+DMARD group, the baricitinib 4 mg, baricitinib 2 mg+DMARD, and adalimumab 40 mg+MTX groups showed a significantly higher ACR20 response rate. The ranking probability based on the surface under the cumulative ranking curve (SUCRA) indicated that baricitinib 4 mg+DMARD was likely to elicit the best ACR20 response rate (SUCRA =0.7930), followed by baricitinib 4 mg (SUCRA =0.7034), baricitinib 2 mg+DMARD (SUCRA =0.6304), adalimumab 40 mg+MTX (SUCRA =0.3687), and placebo+DMARD (SUCRA =0.0045). By contrast, the safety based on the number of treatment-emergent adverse events (TEAEs) did not differ significantly among the 5 interventions. <h3>Conclusions</h3> Baricitinib 2 mg and 4 mg administered once daily was an efficacious intervention for active RA that had no significant risk of TEAE development. <h3>Acknowledgements</h3> None <h3>Disclosure of Interest</h3> None declared
Implications of Coronary Artery Calcium Testing for Treatment Decisions Among Statin Candidates According to the ACC/AHA Cholesterol Management Guidelines
Authors: Jonathan C. Hong, Ron Blankstein, Leslee J. Shaw, William V. Padula, Alejandro Arrieta, Jonathan A. Fialkow, Roger S. Blumenthal, Michael J. Blaha, Harlan M. Krumholz, Khurram Nasir
Journal: JACC. Cardiovascular imaging (2017)
The Benefit Model for Prevention of Cardiovascular Disease
Authors: George Thanassoulis, Michael J. Pencina, Allan D. Sniderman
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
LOOKING BEYOND RECURRENCE; CURRENT METHODS FOR REPORTING MULTIPLE INDIVIDUAL INJURY IN STUDIES OF TEAM BALL SPORTS
Authors: Lauren Fortington, Henk van der Worp, Inge van den Akker-Scheek, Caroline Finch
Journal: British Journal of Sports Medicine (2017)

Background Participants of team ball sports will commonly experience more than one injury over a period of participation. Recording/reporting this can be difficult but it is necessary to provide the most accurate estimates of sports injury incidence. Objective To identify the current methods used to report more than one individual injury in studies of injury incidence in team ball sports. Design Systematic review of literature. Setting Studies of injury incidence in team ball sports. Patients (or Participants) Studies were included if they: reported incidence of all injuries (not specific to one injury type) over the whole time period (e.g. not game-injuries only); were conducted with participants of team ball sports; collected data prospectively; had a follow-up time of &gt;1 calendar-year or ≥2 consecutive-seasons; collected data in a defined cohort (e.g. club, school); used an individual identifier in the collection of data. Interventions (or Assessment of Risk Factors) None. Main Outcome Measurements Number of included studies, definitions of injury and summary of how multiple individual injuries were reported. Results There were 71 studies included, from which the most common presentation of data was pooled injury counts summarised across teams/seasons (n=34). Where multiple injuries were reported (n=37), most studies (n=20) were limited to recurrent injuries only (exact same body part and type.) Eleven studies presented the mean number of injuries per athlete for a specified time (season, study-duration), eight studies reported the range of injuries in athletes. Used infrequently was a measure of risk of injury in subsequent seasons or a statement that some athletes had &gt;1 injury in the season. Conclusions Injury prevention relies on accurate incidence estimates. Ongoing development of methodology in this area is encouraged to advance understanding of the causal underpinnings of sports injuries, and their prevention.
認知症発症前の構造的神経画像:微細構造障害と灰白質萎縮からマクロスケールコネクトミクスへの変化【Powered by NICT】
Authors: Mak Elijah, Gabel Silvy, Mirette Habib, Su Li, Williams Guy B, Waldman Adam, Wells Katie, Ritchie Karen, Ritchie Craig, O’Brien John
Journal: Ageing Research Reviews (2017)
08.08 Podocytes internalise dna-antibody complexes
Authors: Anja Römer-Hillmann, Elisabeth Jung, Annika Engbers, Marcel Reinhardt, Hedda Wardemann, Thomas Pap, Annett Jacobi
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Podocytes are postmitotic visceral epithelial cells, located at the Bowmans capsule of the kidney building up the slit diaphragm with their foot processes to filtrate the blood and keep valuable large proteins in the vessels. In Systemic Lupus Erythematosus (SLE) different organs are affected by autoantibodies which results in chronic inflammation and a high percentage of patients develop Lupus nephritis (LN) resulting in podocyte damage and disruption of the slit diaphragm. The risk for LN correlates directly with the level of anti-double stranded DNA antibodies (adsDNAabs). In this study, we wanted to identify the direct effect of adsDNAabs on podocytes. <h3>Methods</h3> We established an <i>in vitro</i> system to investigate the specific impact of monoclonal antibodies and their immune complexes directly on podocytes (AB8 cell line). Monoclonal antibodies were generated by transfecting HEK293T cell line with Ig heavy and corresponding light chain encoding plasmid DNA obtained from single B cells of patients with SLE and LN. Podocytes were incubated with the produced monoclonal antibodies and the internalisation process and functional consequences were analysed by immunofluorescence, Western Blot, FACS and electron microscopy. For comparison, primary human podocytes were isolated from LN patient urine and analysed by immunofluorescence. <h3>Results</h3> The recombinantly produced adsDNAabs from LN patients were specific against nuclear structures and build complexes with double stranded DNA, essential for the internalisation by cultivated podocytes. Interestingly, viability and migratory capacity were not influenced by the exposure to adsDNAabs for 48 hour. The internalised antibodies were enclosed by membranous structures and reach the cytosol via clathrin dependent endocytosis. The process of internalisation was time and dose dependent and reversible. Furthermore, internalised antibody complexes could also be detected in primary human LN podocytes. <h3>Conclusion</h3> In our <i>in vitro</i> model the specific uptake of adsDNAabs was observed, in line with human LN data. Podocytes from patients with LN show IgG positive aggregates in the cytosol. The internalisation depends on the complex formation of the antibodies with dsDNA and could be important part of the LN pathogenesis.