tbuckley/cabot-search huggingface dataset:
Overexpression of Insulin-Like Growth Factor 1 Enhanced the Osteogenic Capability of Aging Bone Marrow Mesenchymal Stem Cells
Authors: Ching-Yun Chen, Kuo-Yun Tseng, Yen-Liang Lai, Yo-Shen Chen, Feng-Huei Lin, Shankung Lin
Journal: Theranostics (2017)

Many studies have indicated that loss of the osteoblastogenic potential in bone marrow mesenchymal stem cells (bmMSCs) is the major component in the etiology of the aging-related bone deficit.But how the bmMSCs lose osteogenic capability in aging is unclear.Using 2-dimentional cultures, we examined the dose response of human bmMSCs, isolated from adult and aged donors, to exogenous insulin-like growth factor 1 (IGF-1), a growth factor regulating bone formation.The data showed that the mitogenic activity and the osteoblastogenic potential of bmMSCs in response to IGF-1 were impaired with aging, whereas higher doses of IGF-1 increased the proliferation rate and osteogenic potential of aging bmMSCs.Subsequently, we seeded IGF-1-overexpressing aging bmMSCs into calcium-alginate scaffolds and incubated in a bioreactor with constant perfusion for varying time periods to examine the effect of IGF-1 overexpression to the bone-forming capability of aging bmMSCs.We found that IGF-1 overexpression in aging bmMSCs facilitated the formation of cell clusters in scaffolds, increased the cell survival inside the cell clusters, induced the expression of osteoblast markers, and enhanced the biomineralization of cell clusters.These results indicated that IGF-1 overexpression enhanced cells' osteogenic capability.Thus, our data suggest that the aging-related loss of osteogenic potential in bmMSCs can be attributed in part to the impairment in bmMSCs' IGF-1 signaling, and support possible application of IGF-1-overexpressing autologous bmMSCs in repairing bone defect of the elderly and in producing bone graft materials for repairing large scale bone injury in the elderly.
A 5'UTR Polymorphism in NT5E Gene Influences Outcome in Patients with Acute Myeloid Leukemia Undergoing Hematopoietic Stem Cell Transplantation with Fludarabine Based Conditioning Regimen
Authors: Ezhilpavai Mohanan, John C Panetta, Kavitha M Lakshmi, Anup Joseph Devasia, Nisham PN, Anu Korula, Fouzia NA, Aby Abraham, Biju George, Alok Srivastava, Vikram Mathews, Poonkuzhali Balasubramanian
Journal: Blood (2016)
Reply
Authors: Marc S. Ernstoff, Jan Fisher, John D. Seigne, Zbigniew M. Szczepiorkowski, Nancy A. Crosby, Alan R. Schned, Robert D. Harris, Richard J. Barth, John A. Heaney, Thomas Schwaab, Adrian Schwarzer, Benita Wolf, Randolph J. Noelle
Journal: Clinical Cancer Research (2009)
Short-Term Dynamic Psychotherapy
Authors: Ragnhild Husby, Alv A. Dahl, Carl-Ivar Dahl, Astrid Nøklebye Heiberg, Ola M. Olafsen, Lars Weisœth
Journal: Psychotherapy and Psychosomatics (1985)

39 out-patients, 19 men and 20 women with a neurotic personality structure, evaluated by at least 2 therapists, were treated with short-term dynamic psychotherapy. 33 patients were followed up 2 years after the end of treatment with a semi-structured, problem-oriented interview, scored by 3 therapists according to a follow-up form developed for the study. Sufficient reliability was demonstrated for the follow-up form. 11 of 36 patients (31 %), followed up 2 years after the end of treatment, obtained a high score on the dynamic result variable, and 24 (67%) on symptom relief. It could be established that these changes were mostly due to the therapy given. Variables pertaining patients' ability to relate to another person correlated with outcome. This is consistent with what Malan found in his two studies.
The ICM research agenda on extracorporeal life support
Authors: Alain Combes, Dan Brodie, Yih-Sharng Chen, Eddy Fan, José P. S. Henriques, Carol Hodgson, Philipp M. Lepper, Pascal Leprince, Kunihiko Maekawa, Thomas Muller, Sebastian Nuding, Dagmar M. Ouweneel, Antoine Roch, Matthieu Schmidt, Hiroo Takayama, Alain Vuylsteke, Karl Werdan, Laurent Papazian
Journal: Intensive Care Medicine (2017)
Rare Case of Patient with HIV Related Plasmablastic Lymphoma Presenting with Bilateral Parotid Involvement and Hypergammalobulemia
Authors: Damien Hansra, Jorge Antunez de Mayolo, Lisellete Morin, Frank Aranda, Oscar Herrera, Abelardo Arango, Jason Kosove, Maureen Cioffi-Lavina
Journal: Blood (2016)
A Novel Oncolytic Reovirus Immune Priming Strategy Dramatically Enhances the Efficacy of Anti-PD-L1 Antibody Therapy Against Multiple Myeloma
Authors: Kevin R. Kelly, Claudia M. Espitia, Weiguo Zhao, Valeria Visconte, Matt Coffey, Jennifer S. Carew, Steffan T. Nawrocki
Journal: Blood (2016)
Dr Matthew Cross: epidemiology and risk factors for injury in professional rugby union
Authors: Matthew J Cross
Journal: British Journal of Sports Medicine (2017)

The aim of my PhD (figure 1) was to investigate the injury epidemiology and risk factors for injury in professional Rugby Union. I wanted to provide evidence-based guidance to medical practitioners and coaches on concussion management and training periodisation.

### Concussion

Concussive injury is a common occurrence in collision sports, but the evidence base for informing the content and the duration of current graduated return to play guidelines was limited.1 In addition, it had been suggested that premature return to play from concussion could possibly increase the risk of adverse long-term neurological consequences.2 

### Training load

We know that an injury is likely to impact on an individual’s ability to train and compete. Higher injury burden has also been associated with poorer team success in professional football codes.3 4 A player or team’s training load has been shown to be an …
Informed consent training for medical oncology fellows: Checklist-based simulation exercise.
Authors: Nathan M. Shumway, Jennifer Jill Dacus, Kate Ida Lathrop, Elizabeth P. Hernandez, Maria Miller, Anand B. Karnad
Journal: Journal of Clinical Oncology (2014)

e20671 Background: Discussing informed consent (IC) is essential for quality cancer care. While essential elements of IC are clearly defined, there is little data to guide how best to teach IC to medical oncology fellows’ (MOF). A PI project was conducted using a simulation (SIM) exercise to assess the MOF skills in obtaining IC to enhance our teaching of the subject. Methods: Program directors from 2 training sites in San Antonio, TX created a 30-minute SIM lab using standardized patients (SP) and the use of checklists (CKL) for obtaining IC. MOF from both institutions were asked to obtain IC for chemotherapy in a patient with Stage III seminoma. Half the MOF were given an IC checklist prior to their SIM encounter that included 18 side effects (SE) for discussion recommended by ASCO along with 12 essential elements (EE) for IC. All encounters were videotaped and data recorded by 2 faculty. Results: 17 MOF (6 PGY-4s, 6 PGY-5s, and 5 PGY-6s) participated. Video review was available for 15 MOF, and 8/15 were given CKL prior to their encounter. The median number of SE (18 items) discussed was 11 (IQR=7-12) for the entire group. The median number of SE discussed in the CKL group was significantly higher than those without a CKL, 12 (11-14) vs. 9 (6-11); (p=0.04). The median number of EE (12 items) discussed for the entire group was 8 (5-11). The median number of EE discussed in CKL group trended higher than the group without CKL (8 vs 6.5, p=0.06). While 66% of MOF discussed alternatives, only 33% discussed the risks of those alternatives, and only 20% of MOF informed patients they could stop chemotherapy at any time. Fertility was discussed in 47% of all encounters (n=15). Among those with CKL, 71% discussed fertility compared 25% without CKL (p=0.07). Only 13% of MOF discussed risk of secondary malignancy. No MOF discussed sexual SE (0/15). At the conclusion of the encounter, 7% (1/15) of MOF offered the patient a copy of the IC. Conclusions: Using SP and CKL, we were able to objectively measure aspects of our MOF knowledge of the IC process. CKL led to improved SE and EE discussions. Our project suggests that we should focus our efforts on teaching MOF how to discuss alternative therapy, risks, as well SE regarding fertility, sexuality, and risk of secondary malignancy.
Annals Story Slam - Perspective From Abroad
Authors: Stephen J. Gluckman
Journal: Annals of Internal Medicine (2017)

Web Exclusives2 May 2017Annals Story Slam - Perspective From AbroadFREEStephen J. Gluckman, MDStephen J. Gluckman, MDFrom University of Pennsylvania, Philadelphia, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W17-0040 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Perspective From Abroad "Perspective From Abroad," by Dr. Stephen Gluckman (Duration 8:30)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: From University of Pennsylvania, Philadelphia, Pennsylvania.Current Author Address: Stephen J. Gluckman, MD, niversity of Pennsylvania, Philadelphia, PA; e-mail, stephen.[email protected]upenn.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 May 2017Volume 166, Issue 9Page: SS1 ePublished: 2 May 2017 Issue Published: 2 May 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.Loading ...
Haemostasis in Immune Trombocytopenia Patients Responders to Agonists of Thrombopoietin Receptor
Authors: Nora Butta, Ihosvany Fernandez Bello, María Teresa Álvarez Román, Monica Martín Salces, Raul Justo Sanz, Elena Monzon Manzano, María Isabel Rivas Pollmar, Sergio Rivas Muñoz, Miguel Canales, Victor Jiménez Yuste
Journal: Blood (2016)
Emergence of carbapenemase-producing Acinetobacter ursingii in The Netherlands
Authors: E. Sieswerda, R.P. Schade, T. Bosch, J. de Vries, M.E.D. Chamuleau, E.G. Haarman, L. Schouls, K. van Dijk
Journal: Clinical Microbiology and Infection (2017)
Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish
Authors: Neil I Bower, Katarzyna Koltowska, Cathy Pichol-Thievend, Isaac Virshup, Scott Paterson, Anne K Lagendijk, Weili Wang, Benjamin W Lindsey, Stephen J Bent, Sungmin Baek, Maria Rondon-Galeano, Daniel G Hurley, Naoki Mochizuki, Cas Simons, Mathias Francois, Christine A Wells, Jan Kaslin, Benjamin M Hogan
Journal: Nature Neuroscience (2017)
Comparison of the mutational landscape of breast cancer during pregnancy and non-pregnant controls
Authors: S. Loibl, N. Pfarr, K. Weber, S. Villegas-Angel, A. Stenzinger, J. Furlanetto, J. Budczies, F. Marmé, C. Denkert, W. Weichert
Journal: Annals of Oncology (2017)
Interim Data from a Randomized, Placebo Controlled, Phase 1 Study of Aln-AS1, an Investigational RNAi Therapeutic for the Treatment of Acute Hepatic Porphyria
Authors: Eliane Sardh, Pauline Harper, Nabil Al-Tawil, Manisha Balwani, Karl Anderson, Joseph Bloomer, D. Montgomery Bissel, Robert J. Desnick, Charles J. Parker, John D. Phillips, Herbert L. Bonkovsky, Craig Penz, Amy Chan, Chang-Heok Soh, William Querbes, Amy Simon, Penelope Stein, David C. Rees
Journal: Blood (2016)
Chronic Fluid Overload and Mortality in ESRD
Authors: Carmine Zoccali, Ulrich Moissl, Charles Chazot, Francesca Mallamaci, Giovanni Tripepi, Otto Arkossy, Peter Wabel, Stefano Stuard
Journal: Journal of the American Society of Nephrology (2017)

Sustained fluid overload (FO) is considered a major cause of hypertension, heart failure, and mortality in patients with ESRD on maintenance hemodialysis. However, there has not been a cohort study investigating the relationship between chronic exposure to FO and mortality in this population. We studied the relationship of baseline and cumulative FO exposure over 1 year with mortality in 39,566 patients with incident ESRD in a large dialysis network in 26 countries using whole-body bioimpedance spectroscopy to assess fluid status. Analyses were applied across three discrete systolic BP (syst-BP) categories (<130, 130-160, and >160 mmHg), with nonoverhydrated patients with syst-BP=130-160 mmHg as the reference category; >200,000 FO measurements were performed over follow-up. Baseline FO value predicted excess risk of mortality across syst-BP categories (<130 mmHg: hazard ratio [HR], 1.51; 95% confidence interval [95% CI], 1.38 to 1.65; 130-160 mmHg: HR, 1.25; 95% CI, 1.16 to 1.36; >160 mmHg: HR, 1.30; 95% CI, 1.19 to 1.42; all P<0.001). However, cumulative 1-year FO exposure predicted a higher death risk (P<0.001) across all syst-BP categories (<130 mmHg: HR, 1.94; 95% CI, 1.68 to 2.23; 130-160 mmHg: HR, 1.51; 95% CI, 1.35 to 1.69; >160 mmHg: HR, 1.62; 95% CI, 1.39 to 1.90). In conclusion, chronic exposure to FO in ESRD is a strong risk factor for death across discrete BP categories. Whether treatment policies that account for fluid status monitoring are preferable to policies that account solely for predialysis BP measurements remains to be tested in a clinical trial.
Redox Responsive Hyaluronic Acid Nanogels for Treating RHAMM (CD168) Over-expressive Cancer, both Primary and Metastatic Tumors
Authors: Chenchen Yang, Cheng Li, Peng Zhang, Wei Wu, Xiqun Jiang
Journal: Theranostics (2017)

It remains a substantial challenge to targetedly deliver drug to both primary tumors and metastatic lesions employing a single nanoparticle delivery system. Here aiming at the receptor for hyaluronic acid mediated motility (RHAMM or CD168), a specific receptor for hyaluronic acid (HA), the bioreductive responsive HA nanogels loaded doxorubicin were prepared. The targeting effects of HA nanogels in high RHAMM-expressed cancer cells, primary and metastatic tumors were investigated. It was found that HA nanogels show a strong
Ascertainment Bias in Statin Use and Alzheimer Disease Incidence
Authors: D. Michal Freedman, Ruth M. Pfeiffer
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients
Authors: Sameer Agnihotri, Aaron S. Gajadhar, Christian Ternamian, Thierry Gorlia, Kristin L. Diefes, Paul S. Mischel, Joanna Kelly, Gail McGown, Mary Thorncroft, Brett L. Carlson, Jann N. Sarkaria, Geoffrey P. Margison, Kenneth Aldape, Cynthia Hawkins, Monika Hegi, Abhijit Guha
Journal: Journal of Clinical Investigation (2012)
Prevalence of Helicobacter pylori: An Irish Experience in a Dublin Associated Teaching Hospital over a Six Year Period
Authors: VO Chan, SG Veerappan, O Thornton, M Dobson, B Ryan, N Breslin, H O'Connor, P Crotty, C O'Morain
Journal: Endoscopy (2006)

Aims: To determine age-specific and change in prevalence of Helicobacter pylori (HP) over a 6 year period.
BURNS AND SCALDS.
Authors: C. K. COLE
Journal: JAMA (1897)

In our work as railroad surgeons we are often called upon to treat burns and scalds in their various forms and degrees, and nearly as often find an unsatisfactory state of affairs regarding the condition of the patient. The severity of the burn, its first treatment by rough hands, and the time since the infliction of the injury are all important factors. These, together with some hints as to methods of treatment, will be considered. Often we find a patient begrimed from head to foot with coal dust, oil and cinders, suffering with a severe burn, received hours before, with the injured member drenched in machine or engine oil and wrapped in dirty, oily waste, and an internal drenching of whisky or brandy. This condition must be met promptly, and here begins the tiresome task of cleansing and rendering the parts aseptic. These are the times that try our patience.
The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation
Authors: Samir M. Parikh
Journal: Journal of the American Society of Nephrology (2017)

Systemic inflammation is a hallmark of commonly encountered diseases ranging from bacterial sepsis to sterile syndromes such as major trauma. Derangements in the host vasculature contribute to the cardinal manifestations of sepsis in profound ways. Recent studies of control pathways regulating the vascular endothelium have illuminated how this single cell layer toggles between quiescence and activation to affect the development of shock and multiorgan dysfunction. This article focuses on one such control pathway, the Tie2 receptor and its ligands the angiopoietins, to describe a growing body of genetic, biochemical, mechanistic, and human studies that implicate Tie2 as a critical switch. In health, activated Tie2 maintains the endothelium in a quiescent state characterized by dynamic barrier function and antiadhesion against circulating leukocytes. In sepsis and related diseases, expression of the angiopoietins becomes markedly imbalanced and Tie2 signaling is greatly attenuated. These rapid molecular changes potentiate pathophysiologic responses throughout the body, resulting in injurious vascular leakage and organ inflammation. The Tie2 axis, therefore, may be a promising avenue for future translational studies.
Initiation of Trastuzumab by Women Younger Than 64 Years for Adjuvant Treatment of Stage I–III Breast Cancer
Authors: Huei-Ting Tsai, Claudine Isaacs, Filipa C. Lynce, Suzanne C. O'Neill, Chunfu Liu, Marc D. Schwartz, Nandini Selvam, Yingjun Zhou, Arnold L. Potosky
Journal: Journal of the National Comprehensive Cancer Network (2017)

Purpose: Studies have reported disparities by age and race in the initiation of adjuvant trastuzumab for the initial treatment of older women with early-stage breast cancer, but less is known about its initiation in younger patients. Therefore, we assessed temporal trends and clinical and demographic factors associated with trastuzumab initiation in a large, population-based cohort of patients aged <64 years in 5 states. Methods: Using a cancer registry and claims-linked data set of 13,398 women with incident invasive breast cancer from 2006 to 2011, we identified 934 patients aged <64 years with HER2-positive stage I–III breast cancer. We assessed trastuzumab initiation within the first 9 months after diagnosis and conducted logistic regression analyses to assess sociodemographic and clinical factors associated with trastuzumab initiation. Results: From 2006 to 2011, trastuzumab initiation steadily increased in patients with node-positive (from 65% to 91%) and node-negative (from 39% to 75%) breast cancers. Several tumor-related factors were associated with trastuzumab initiation, including high histologic grades (adjusted odds ratio [aOR], 6.43; 95% CI, 3.27–12.65; and aOR, 3.25; 95% CI, 1.66–6.36, for grades 3 and 2, respectively), node-positive status (aOR, 1.88; 95% CI, 1.28–2.78; P=.001), tumor size >2 cm (aOR, 1.50; 95% CI, 1.04–2.16; P=.03), and hormone receptor–negative status (aOR, 1.51; 95% CI, 1.01–2.26; P=.04). We found a null effect of race. Conclusions: Adjuvant trastuzumab therapy for early-stage breast cancer has been widely disseminated among women aged <64 years. The initiation of this targeted therapy was associated with higher-risk features, consistent with practice guidelines.
Early Relapse Following ASCT for Patients with MM: Identification of Predictor Factors in the Era of Novel Agents
Authors: Victor Jimenez-Zepeda, Peter Duggan, Paola Neri, Ahsan Chaudhry, Jason Tay, Joanne Luider, Fariborz Rashid-Kolvear, Nizar J. Bahlis
Journal: Blood (2016)
David Oliver: Fighting pyjama paralysis in hospital wards
Authors: David Oliver
Journal: BMJ (2017)

The momentum of Nottingham University Hospitals’ social media campaign “End PJ Paralysis” has been growing,1 with clinical teams around the country joining in and reports appearing in the national media.2

Its starting premise is that we should get more hospital inpatients out of nightwear, out of bed, and into their day clothes to speed their recovery and help minimise harms from prolonged immobility.

The perils of bed rest as treatment for hospital inpatients were recognised in the 1940s by Richard Asher, in his seminal essay The Dangers of Going to Bed ,3 and they were elegantly …
Addendum: RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci
Authors: Susannah L Hewitt, Bu Yin, Yanhong Ji, Julie Chaumeil, Katarzyna Marszalek, Jeannette Tenthorey, Giorgia Salvagiotto, Natalie Steinel, Laura B Ramsey, Jacques Ghysdael, Michael A Farrar, Barry P Sleckman, David G Schatz, Meinrad Busslinger, Craig H Bassing, Jane A Skok
Journal: Nature Immunology (2010)
Clinical Retrospective Analysis of 42 Patients with Primary Bone Lymphoma Treated at Maisonneuve-Rosemont Hospital
Authors: Katie Guo, Melissa Boileau, Bernard Fortin, Francine Aubin, Tony Petrella, Marc Isler, Sophie Mottard, Sandra Cohen, Luigina Mollica, Julie Beaudet, Isabelle Fleury
Journal: Blood (2016)