tbuckley/cabot-search huggingface dataset:
Adapting US service learning projects to other cultures: dementia and memory care in the Dominican Republic
Authors: Christine A Tisone, Idethia S Harvey
Journal: The Lancet Global Health (2018)

BackgroundCaring for older populations with dementia is a global challenge. The cultural context in which ageing occurs is an important factor that influences treatment and daily care strategies for those with dementia, including location (home or health-care facility) and choice of caretakers (family members or health-care personnel). We adapted a successful US memory care service learning project for university students in the USA to pilot test in the Dominican Republic.Methods18 health majors from Texas A&M University participated in a special topics course dedicated to culture, ageing, and dementia. The group spent 2 weeks in Jarabacoa, Dominican Republic, immersed in the culture, studying, and volunteering at a local assisted-living facility. Five memory care sessions (3-h each) were held with the same 25 residents over the 2-week period. The principal activities were spice-painting (a technique which triggers the olfactory sense and stimulates parts of the brain associated with long-term memory) and life story interviews.FindingsThe staff and residents of the assisted-living facility demonstrated great appreciation for our presence and for the engaging activities. Staff reported that they do not have the human resources necessary to conduct similar activities. Furthermore, they confirmed that, within the Dominican culture, most older people are cared for in their homes, and that there is a stigma associated with sending loved ones to this type of facility. This affects the resources available to the facility. Student evaluations and reflective essays completed after their experience indicated enthusiasm for the project (100% highly satisfied), personal growth, and appreciation for the cultural immersion opportunity.InterpretationIn May, 2018, we will adapt the project to better fit the needs of the Dominican health system by partnering with a Dominican university, thus creating a sustainable volunteer system. We will also expand to include families in the area that are caring for their older relatives with dementia in their homes, by conducting home visits and community education sessions; in this way, families can learn the memory care activities and conduct them on their own.FundingNone.
Are Medicaid Work Requirements Legal?
Authors: Nicholas Bagley
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The “RENAISSANCE” Trial: Effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction—A phase III trial of the German AIO/CAO-V/CAOGI.
Authors: Daniel Wilhelm Mueller, Stefan Paul Moenig, Arndt Vogel, Sylvie Lorenzen, Nils Homann, Christoph Reissfelder, Claus Bolling, Wolfgang Blau, Wolff H. Schmiegel, Patrick Michl, Karel Caca, Matthias Schwarzbach, Ralf Hofheinz, Claus Roedel, Manish A. Shah, Mitsuru Sasako, Wolf O. Bechstein, Hauke Lang, Claudia Pauligk, Salah-Eddin Al-Batran
Journal: Journal of Clinical Oncology (2017)

TPS4140 Background: Recent data indicates that surgical resection may bring a benefit for select patients with metastatic gastric / esophagogastric junction cancer. However, no data obtained in randomized trials is available up to now. The current RENAISSANCE trial investigates this long-lasting question about the role of surgical intervention in limited-metastatic gastric / esophagogastric junction cancer. Methods: This is a prospective, multicenter, randomized, investigator initiated phase III trial. In this study, previously untreated patients with limited metastatic stage (retroperitoneal lymph node metastases only or a maximum of one incurable organ site that is potentially resectable or locally controllable with or without retroperitoneal lymph nodes) will receive 4 cycles of FLOT (docetaxel 50 mg/m²; oxaliplatin 85 mg/m²; leucovorin 200 mg/m²; 5-FU 2,600 mg/m²), and if Her2+ with trastuzumab. Patients without disease progression after 4 cycles are randomized 1:1 to receive additional chemotherapy cycles or surgical resection of primary and metastases followed by subsequent chemotherapy. 271 patients are to be allocated to the trial, of which at least 176 patients will be randomized. The primary endpoint is overall survival; main secondary endpoints are quality of life parameters as assessed by EORTC-QLQ-C30 questionnaire, progression free survival and surgical morbidity and mortality. Recruitment has already started; currently (Feb 2017) 21 patients have been enrolled. EudraCT: 2014-002665-30. Clinical trial information: NCT02578368.
Were Wolves Meet Dermatology
Authors: Randy Atkins, Mi Hye Song, Ashley Sturgeon
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
MPs quiz doctors over views on training funds and private sector involvement in medical training
Authors: Ingrid Torjesen
Journal: BMJ (2012)

Medical professional bodies and unions giving evidence to the parliamentary select committee on health yesterday were united in their call for training budgets to be ringfenced to prevent money being siphoned off for service provision.

Representatives of the BMA, the Royal College of Nursing, the public sector trade union Unison, and the Community Practitioners’ and Health Visitors’ Association of the union Unite were invited to tell MPs on the Health Committee their views of the government’s plans to restructure the provision of training, increase the involvement of employers in training and workforce decisions, and involve the private sector in provision of training.

MPs asked the four witnesses their views on the provision of funding. All agreed that funding for training needed to be ringfenced to protect it from being diverted …
Agreement is reached on draft framework for new consultants’ contract
Authors: Caroline White
Journal: BMJ (2013)

The BMA and the government’s negotiating body, NHS Employers, have published a draft framework for a possible formal renegotiation of the contract for consultants working in England and Northern Ireland.

The publication of the draft heads of terms follows on from exploratory talks held between the two organisations, including representatives from the devolved nations.

The draft of the heads of terms principally focuses on three key areas: exploration of contractual …
New Human Insulin Analog Approved
Authors: Rebecca Voelker
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Possible Underestimation of the Provision of Palliative Care—Reply
Authors: Yael Schenker, Robert Arnold
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
A STEP FORWARD IN THE MINIMALIST STRATEGY FOR TRANSFEMORAL TRANSCATHETER AORTIC VALVE IMPLANTATION WITH THE EDWARDS SAPIEN-XT PROSTHESIS: FEASIBILITY AND SAFETY OF EARLY DISCHARGE
Authors: Guillaume Avinee, Carlos Rodriguez, Joseph Nader, Guillaume Viart, Guillaume Cellier, Anaelle Abisror, Matthieu Godin, Christophe Tron, Eric Durand, G. Alain Cribier, Helene Eltchaninoff
Journal: Journal of the American College of Cardiology (2015)
Is IT the end for doctors?
Authors: Thomas Foley
Journal: BMJ (2016)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Is IT the end for doctors? Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Peli1 Modulates the Subcellular Localization and Activity of Mdmx
Authors: Dawei Li, Omid Tavana, Shao-Cong Sun, Wei Gu
Journal: Cancer Research (2018)

Mdm2 and Mdmx, both major repressors of p53 in human cancers, are predominantly localized to the nucleus and cytoplasm, respectively. The mechanism by which subcellular localization of Mdmx is regulated remains unclear. In this study, we identify the E3 ligase Peli1 as a major binding partner and regulator of Mdmx in human cells. Peli1 bound Mdmx in vitro and in vivo and promoted high levels of ubiquitination of Mdmx. Peli1-mediated ubiquitination was degradation-independent, promoting cytoplasmic localization of Mdmx, which in turn resulted in p53 activation. Consistent with this, knockdown or knockout Peli1 in human cancer cells induced nuclear localization of Mdmx and suppressed p53 activity. Myc-induced tumorigenesis was accelerated in Peli1-null mice and associated with downregulation of p53 function. Clinical samples of human cutaneous melanoma had decreased Peli1 expression, which was associated with poor overall survival. Together, these results demonstrate that Peli1 acts as a critical factor for the Mdmx-p53 axis by modulating the subcellular localization and activity of Mdmx, thus revealing a novel mechanism of Mdmx deregulation in human cancers.Significance: Peli1-mediated regulation of Mdmx, a major inhibitor of p53, provides critical insight into activation of p53 function in human cancers. Cancer Res; 78(11); 2897-910. ©2018 AACR.
Recruitment problems are creating a two tier system in emergency department staffing, college warns
Authors: Tom Moberly
Journal: BMJ (2015)

Problems in persuading emergency medicine doctors to work in some areas of the country have created a two tier system of staffing in UK emergency departments, the College of Emergency Medicine has warned.

Kevin Reynard, a vice president of the college, raised the issue at its conference this month. He noted “many problems with recruitment across the country” when it came to filling non-training grade posts in emergency medicine.

“We …
Department of Health announces first clinical commissioning groups to be authorised
Authors: Helen Jaques
Journal: BMJ (2012)

The first 35 clinical commissioning groups (CCGs) set to be authorised by the NHS Commissioning Board have been announced.

The groups will be signed off by the board in the first wave of authorisations in July this year and will take on full responsibility for clinical commissioning in April 2013.

“All the emerging clinical commissioning groups have made fantastic progress to prepare themselves …
Editor’s Choice: Gathering evidence and acting on it
Authors: Tom Moberly
Journal: BMJ (2015)

More young doctors want some extra life in their work-life balance, more medical fathers want to reduce their working hours, and more women are working as doctors. These three factors, and many more, have meant that the number of doctors wanting to take up less than full time (LTFT) training has risen across all specialties. This has been recognised by …
Laparoscopy and endoscopy cooperative surgery for gastric tumor.
Authors: Ozawa Hiroki, Hirofumi Kawakubo, Shuhei Mayanagi, Kazumasa Fukuda, Osamu Goto, Rieko Nakamura, Koichi Suda, Norihito Wada, Naohisa Yahagi, Yuko Kitagawa
Journal: Journal of Clinical Oncology (2018)

168 Background: Laparoscopic wedge resection is widely performed for managing gastric submucosal tumors (SMTs) that measure ≤5 cm in diameter. Laparoscopy and endoscopy cooperative surgery (LECS) is performed to ensure a sufficient margin while avoiding deformation or stenosis. Methods: We conducted a retrospective review of the data of 76 patients who underwent LECS for SMTs or early gastric cancers at our institution between April 2012 and July 2017. While Non-exposed Endoscopic Wall-inversion Surgery (NEWS) was performed for tumors with a major axis diameter of ≤5 cm and minor axis diameter of ≤3 cm, for other tumors, we adopted classical LECS or used the combination of laparoscopic approaches to neoplasia with non-exposure technique (CLEAN-NET). Results: The tumor was located in the upper-/middle-/lower-third of the stomach in 49/20/7 cases. The mean operation time was 201.7 ± 66.2 min, and the mean blood loss was 4.7 ± 12.8 ml. The mean tumor size was 28.6 ± 11.6 mm. The histological tumor types included GIST (n = 38), leiomyoma (n = 14), schwannoma (n = 6), early gastric cancer (n = 8) and others (n = 10). The surgical procedure consisted of classical LECS/CLEAN-NET/NEWS in 17/15/44 cases; all early gastric cancers were treated by NEWS. The mean length of postoperative hospital stay was 8.7 ± 3.9 days. The mean serum levels of C-reactive protein on POD1 and POD3 were 3.2 ± 1.9 and 4.4 ± 3.4 mg/dl, respectively. The postoperative complications were anastomotic stenosis (n = 1), delayed gastric emptying (n = 3), pneumonia (&gt;Grade II by the Clavien-Dindo classification) (n = 1) and exacerbation of GERD (&gt;Grade II by the Clavien-Dindo classification) (n = 3). In the patient group that developed complications, the postoperative resumption of water intake was later, and the postoperative hospital stay was longer as compared to the group without complications (p = 0.04, 0.028). No relationship was observed between the likelihood of development of complications and the tumor location. Conclusions: Use of minimally invasive surgical procedures such as LECS could minimize the extent of gastric resection without deformation, stenosis. We consider that for surgical complications the LECS approach can be employed, regardless of the tumor location.
B7-H3 Negatively Modulates CTL-Mediated Cancer Immunity
Authors: Kimio Yonesaka, Koji Haratani, Shiki Takamura, Hitomi Sakai, Ryoji Kato, Naoki Takegawa, Takayuki Takahama, Kaoru Tanaka, Hidetoshi Hayashi, Masayuki Takeda, Sigeki Kato, Osamu Maenishi, Kazuko Sakai, Yasutaka Chiba, Takafumi Okabe, Keita Kudo, Yoshikazu Hasegawa, Hiroyasu Kaneda, Michiko Yamato, Kenji Hirotani, Masaaki Miyazawa, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Clinical Cancer Research (2018)

Purpose: Anti-programmed-death-1 (PD-1) immunotherapy improves survival in non-small cell lung cancer (NSCLC), but some cases are refractory to treatment, thereby requiring alternative strategies. B7-H3, an immune-checkpoint molecule, is expressed in various malignancies. To our knowledge, this study is the first to evaluate B7-H3 expression in NSCLCs treated with anti-PD-1 therapy and the therapeutic potential of a combination of anti-PD-1 therapy and B7-H3 targeting.Experimental Design: B7-H3 expression was evaluated immunohistochemically in patients with NSCLC (n = 82), and its relationship with responsiveness to anti-PD-1 therapy and CD8+ tumor-infiltrating lymphocytes (TILs) was analyzed. The antitumor efficacy of dual anti-B7-H3 and anti-programmed death ligand-1 (PD-L1) antibody therapy was evaluated using a syngeneic murine cancer model. T-cell numbers and functions were analyzed by flow cytometry.Results: B7-H3 expression was evident in 74% of NSCLCs and was correlated critically with nonresponsiveness to anti-PD-1 immunotherapy. A small number of CD8+ TILs was observed as a subpopulation with PD-L1 tumor proportion score less than 50%, whereas CD8+ TILs were still abundant in tumors not expressing B7-H3. Anti-B7-H3 blockade showed antitumor efficacy accompanied with an increased number of CD8+ TILs and recovery of effector function. CD8+ T-cell depletion negated antitumor efficacy induced by B7-H3 blockade, indicating that improved antitumor immunity is mediated by CD8+ T cells. Compared with a single blocking antibody, dual blockade of B7-H3 and PD-L1 enhanced the antitumor reaction.Conclusions: B7-H3 expressed on tumor cells potentially circumvents CD8+-T-cell-mediated immune surveillance. Anti-B7-H3 immunotherapy combined with anti-PD-1/PD-L1 antibody therapy is a promising approach for B7-H3-expressing NSCLCs. Clin Cancer Res; 24(11); 2653-64. ©2018 AACR.
Shared neural coding for social hierarchy and reward value in primate amygdala
Authors: Jérôme Munuera, Mattia Rigotti, C. Daniel Salzman
Journal: Nature Neuroscience (2018)

The social brain hypothesis posits that dedicated neural systems process social information. In support of this, neurophysiological data have shown that some brain regions are specialized for representing faces. It remains unknown, however, whether distinct anatomical substrates also represent more complex social variables, such as the hierarchical rank of individuals within a social group. Here we show that the primate amygdala encodes the hierarchical rank of individuals in the same neuronal ensembles that encode the rewards associated with nonsocial stimuli. By contrast, orbitofrontal and anterior cingulate cortices lack strong representations of hierarchical rank while still representing reward values. These results challenge the conventional view that dedicated neural systems process social information. Instead, information about hierarchical rank-which contributes to the assessment of the social value of individuals within a group-is linked in the amygdala to representations of rewards associated with nonsocial stimuli.
Projects in controlled environments (PRINCE2). Two levels: foundation and practitioner
Authors: Rachel Hooke
Journal: BMJ (2007)

FURTHER INFORMATION 

Also see: Office of Government Commerce—www.ogc.gov.uk/methods\_prince\_2.asp ADM Group—www.apmgroup.co.uk

Project managers in any industry. Doctors with a project management role, including research. I would not recommend it for doctors who are not involved with projects or management.

November 2006. I had been in management for several years, having originally been a senior house officer.

At the time, I was a project manager for a national pilot for the junior doctors' Working Time Directive for 2009. I was expected …
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice
Authors: Sarah J. Mitchell, Michel Bernier, Miguel A. Aon, Sonia Cortassa, Eun Young Kim, Evandro F. Fang, Hector H. Palacios, Ahmed Ali, Ignacio Navas-Enamorado, Andrea Di Francesco, Tamzin A. Kaiser, Tyler B. Waltz, Ning Zhang, James L. Ellis, Peter J. Elliott, David W. Frederick, Vilhelm A. Bohr, Mark S. Schmidt, Charles Brenner, David A. Sinclair, Anthony A. Sauve, Joseph A. Baur, Rafael de Cabo
Journal: Cell Metabolism (2018)
MA in clinical education
Authors: David Mendel
Journal: BMJ (2010)

I took a Master of Arts (MA) in clinical education at the Institute of Education, University of London.

The course is appropriate for practitioners of all disciplines involved in education within a clinical environment, including dentists and nurses as well as doctors from primary and secondary care.

I started in autumn 2007, during my 25th year as a principal in general practice. I was in the first cohort of students to take the course, which was launched that term as a collaboration between the Institute of Education and the London Deanery.

I wished to deepen my understanding of the theory and practice of clinical education and enhance the quality of the teaching I could provide to learners and the educational courses …