PHYSIOLOGICAL REACTIONS OF THE THYROID STIMULATING HORMONE OF THE PITUITARY. II. THE EFFECT OF NORMAL AND PATHOLOGICAL HUMAN THYROID TISSUES ON THE ACTIVITY OF THE THYROID STIMULATING HORMONE
Authors: Rulon W. Rawson, Ruth M. Graham, Charlotte B. Riddell
Journal: Annals of Internal Medicine (1943)

Article1 September 1943PHYSIOLOGICAL REACTIONS OF THE THYROID STIMULATING HORMONE OF THE PITUITARY. II. THE EFFECT OF NORMAL AND PATHOLOGICAL HUMAN THYROID TISSUES ON THE ACTIVITY OF THE THYROID STIMULATING HORMONERULON W. RAWSON, RUTH M. GRAHAM, CHARLOTTE B. RIDDELLRULON W. RAWSONSearch for more papers by this author, RUTH M. GRAHAMSearch for more papers by this author, CHARLOTTE B. RIDDELLSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-3-405 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONMany investigators1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13have demonstrated an impressive similarity between changes induced in laboratory animals treated with the thyroid stimulating hormone of the pituitary (TSH), and the clinical entity, Graves' disease. Such changes include hyperplasia of the thyroid, tachycardia, weight loss, increase in oxygen consumption, and exophthalmos. On the basis of such observations one might be tempted to conclude that the pituitary is a factor in the etiology of clinical thyrotoxicosis. However, one serious objection to such a conclusion is the fact that several investigators14, 15, 16, 17, 18...Bibliography1. UHLENHUTHSCHWARTZBACH ES: Anterior lobe substance, the thyroid stimulator. The effect of anterior lobe substance on the thyroid gland, Proc. Soc. Exper. Biol. and Med., 1928, xxvi, 152. CrossrefGoogle Scholar2. UHLENHUTH E: The thyreoactivator hormone. Its isolation from the anterior lobe of the bovine pituitary gland and its effects on the thyroid gland, Trans. Am. Assoc. for the Study of Goiter, 1936, page 25. Google Scholar3. LOEBBASSETT LRB: Effect of hormones of anterior pituitary on thyroid gland in guinea pig, Proc. Soc. Exper. Biol. and Med., 1929, xxvi, 860. CrossrefGoogle Scholar4. 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