tbuckley/cabot-search huggingface dataset:
AB1024 Ultrasound in giant cell arteritis: cut-off and pitfalls in the halo sign
Authors: E De Miguel, LM Beltran, I Monjo, F Deodati, WA Schmidt, J García-Puig
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> At the age of presentation of Giant Cell Arteritis (GCA) atherosclerosis is common. The ultrasonographic (US) appearance of athermanous plaque is usually easily differentiated from the hypoechoic halo of GCA. However, the US appearance of the increased of the intima-media-thickness (IMT) in an atherosclerotic carotid artery may have similar image appearance as the halo sign. We hypothesize that atherosclerosis could produce an increase of temporal artery (TA) IMT and cause false-positives halo sign. <h3>Objectives</h3> The aim of this study was to explore the better cut-off in the IMT of TA to minimise the number of false-positive GCA diagnosis caused by atherosclerosis. <h3>Methods</h3> Consecutive non selected patients, ≥50 years-old with high vascular risk according to European Guidelines on cardiovascular disease prevention, and without signs or symptoms of GCA, were included. <i>Ultrasonography of carotid artery:</i> Carotid US examinations were performed on a Mylab Seven (Esaote Medical Systems, Italy) with a 4–13 MHz linear-array. The system employed dedicated software radiofrequency-tracking technology to obtain IMT (QIMT®). <i>Ultrasonography of temporal superficial artery:</i> A color Doppler ultrasound (CDU) and grey scale measure of the IMT/halo sign in both TA and its branches was performed by a second experienced sonographer. A Mylab Twice equipment (Esaote, Geneve, Italy) was used, with a 22 MHz frequency for grey scale and a 12.5 MHz for CDU (color gain of 51, PRF of 2 kHz). The sonographer was blind to the clinical and carotid ultrasound IMT data. <h3>Results</h3> Forty patients were studied, 28 men (70%), with a mean age of 70,6±6,9 years. Three patients were active smokers and 27 ex-smokers. Arterial hypertension was present in 39 (97.5%), dyslipidaemia in 34 (85%) and diabetes in 19 (47.5%). The mean erythrocyte sedimentation rate was 13.6±11.0. The table shows that an IMT &gt;0.30 mm (halo sign) was seen in at least 1 TA branch of 18 patients (45%) with 33 TA branches affected (20.6%). An IMT cut-off &gt;0.34 mm, was present in 4 patients (10%). When at least two affected branches with this measure were required to make the US diagnosis (criteria recommended to improve specificity) only one patient (2.5%) produced a false-positive halo sign. <h3>Conclusions</h3> To the best of our knowledge, this is the first communication indicating that atherosclerosis is a potential cause of false-positive halo sign. We propose a cut-off of AT IMT &gt;0.34 mm in at least two branches to minimise the number of false positives in GCA diagnosis. <h3>Disclosure of Interest</h3> None declared
Acute Ischemic Stroke
Authors: H. Bart van der Worp, Jan van Gijn
Journal: New England Journal of Medicine (2007)

A 62-year-old man has sudden weakness of the left arm and leg and slurred speech. Except for untreated hypertension, his medical history is unremarkable. He is a current smoker with a smoking history of 45 pack-years. On arrival at the emergency department 1 hour 15 minutes after the onset of symptoms, he reports no headache or vomiting. His blood pressure is 180/100 mm Hg; his pulse is 76 beats per minute and is regular. How should this patient be evaluated and treated in the short term?
Early-Onset Sepsis Calculator—Risk of Delaying Treatment
Authors: Sharina Rajbhandari, Edmund F. La Gamma
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Sleep panic attacks: new clinical findings and theoretical implications
Authors: T A Mellman, T W Uhde
Journal: American Journal of Psychiatry (1989)

Forty-five panic disorder patients and 26 normal control subjects were surveyed regarding their histories of sleep panic attacks, insomnia, and vulnerability to exogenous panic stimuli. Sixty-nine percent (N = 31) of the patients reported having experienced sleep panic at some time in their lives, and 33% (N = 15) of the patients experienced recurrent sleep panic. The implications of these findings for the management of panic disorder are discussed.
Abstract 17616: Recurrent Copy Number Variants are Enriched in Bicuspid Aortic Valve and Affect Cardiac Developmental Genes
Authors: Siddharth Prakash, Neil A Hanchard, Dong-Chuan Guo, Kim L McBride, John W Belmont, Simon C Body, Dianna M Milewicz
Journal: Circulation (2015)

Introduction: Bicuspid Aortic Valve (BAV) is the most common adult congenital heart defect. The spectrum of BAV ranges from chromosomal disorders such as Turner syndrome to sporadic isolated disease of unknown cause. We hypothesized that genomic copy number variants (CNVs) contribute causally to BAV. Methods: We conducted genome-wide SNP array analyses of BAV cases in six European American cohorts (3533 total subjects, 31% BAV, 45% female, ages 1-94 years) with sporadic or familial thoracic aortic aneurysms (37%), congenital left ventricular outflow tract obstructive defects (47%) or Turner syndrome (10%). Genotyping was performed on Illumina Omni microarrays, using PennCNV, Nexus and CNVPartition for CNV detection. Thresholds were set at a minimum of six consecutive SNPs for CNVs that were identified by at least two algorithms and intersect with known genes. A total of 1380 BAV cases were compared to 1065 cases with tricuspid aortic valves and 7013 dbGAP controls without a history of cardiovascular disease using association tests for rare CNVs as implemented in PLINK. Pathway and functional analyses of rare CNVs were performed using the ToppGene analysis suite. Genes within rare CNVs were prioritized by their connectivity to genes in the Notch pathway or established roles in human or animal cardiac phenotypes. Results: We identified 12 rare CNV regions that were recurrent in at least three different BAV groups and were absent or extremely rare (frequency &lt;0.1%) in controls. Four of these regions involved genes that cause aortic valve or outflow tract defects when mutated. The largest and most prevalent of the recurrent CNVs were at Xq28 (four duplications and two deletions), at 22q11.21, telomeric to the DiGeorge syndrome critical region (four deletions, three duplications), and at 7p15.2 (four deletions). The percentage of individuals harboring rare CNVs was significantly greater in BAV cases than in tricuspid or dbGAP controls. Conclusions: We identified multiple loci affected by rare CNVs in BAV subjects, demonstrating the genetic heterogeneity of BAV and implicating alterations of candidate genes at these loci in the pathogenesis of BAV.
Abstract 067: Long-Term Ivabradine Treatment Does Not Preserve Myocardial Perfusion and Coronary Reserve in Middle-Aged Rats with Large Myocardial Infarction
Authors: Eduard I Dedkov, Yevgen Bogatyryov, Daniela McCooey, Lance P Christensen, Robert J Tomanek
Journal: Circulation Research (2013)

Background: We have previously shown that 1-month treatment with ivabradine (IVA), the selective cardiac pacemaker I f current inhibitor, preserved myocardial perfusion and coronary perfusion reserve in post-MI middle-aged rats. However, the persistence of this cardioprotective effect after a prolonged period of IVA treatment remains to be determined. Methods: Acute MI was induced in 12-month-old male Sprague-Dawley rats by left coronary artery ligation. Twenty four hours later, the rats with a confirmed large transmural MI (&gt;50% of the left ventricular (LV) free wall) were randomly assigned in two experimental groups. In a first group, rats were treated with IVA i.p. via osmotic pumps in a dose of 10.5 mg/kg/day for 3 months (MI+IVA). In a second group, rats received placebo treatment (5% dextrose) during the same time period (MI). Sham-operated rats served as an age-matched control. At the end of experimental period, myocardial perfusion (baseline and maximal coronary conductance per 100g of tissue) and coronary perfusion reserve (fold increase between baseline and maximal coronary conductance) were determined in non-infarcted LV free wall and interventricular septum by using the neutron-activated stable isotope-labeled microsphere technique. Results: During 3 months of IVA treatment, heart rate in MI+IVA rats was consistently reduced compared to untreated MI rats by mean of 30.6%. Nevertheless, we found that the infarct size and the extent of LV remodeling were relatively comparable between MI and MI+IVA rats three months after surgery. Moreover, the levels of baseline and maximal coronary conductance were similar in LV free wall and septum between two experimental groups. Consequently, IVA-treated rats revealed no difference in coronary perfusion reserve as compared to untreated post-MI animals (2.22±0.46 vs. 2.59±0.41 in LV free wall and 2.30±0.59 vs. 2.68±0.44 in septum, respectively). However, the rats of both post-MI groups had markedly reduced levels of maximal coronary blood flow as compared to non-infarcted controls (p≤0.01). Conclusion: Our data demonstrate that long-term IVA treatment does not provide sustainable improvement in LV myocardial perfusion and coronary perfusion reserve in middle-aged rats following large MI.
老化と緑内障における線維柱帯の機能変化へのDNA損傷から【Powered by NICT】
Authors: Sacca Sergio Claudio, Gandolfi Stefano, Bagnis Alessandro, Manni Gianluca, Damonte Gianluca, Traverso Carlo Enrico, Izzotti Alberto
Journal: Ageing Research Reviews (2016)
Abstract 12824: Comparison of Tissue Doppler-Derived and Speckle Tracking-Derived Parameters for the Estimation of Left Ventricular Filling Pressure: A Multicenter Study in Japan
Authors: Taichi Hayashi, Satoshi Yamada, Masahiro Nakabachi, Hiroyuki Iwano, Mamoru Sakakibara, Kazunori Okada, Daisuke Murai, Hisao Nishino, Kenya Kusunose, Kiyotaka Watanabe, Tomoko Ishizu, Kazuaki Wakami, Hirotsugu Yamada, Kaoru Dohi, Yoshihiro Seo, Nobuyuki Ohte, Taisei Mikami, Hiroyuki Tsutsui
Journal: Circulation (2014)

Background: We conducted a multicenter study in Japan to compare tissue Doppler echocardiography-derived and speckle tracking echocardiography (STE)-derived parameters of left ventricular (LV) diastolic function for the estimation of LV filling pressure. Methods: Seventy-eight patients (age 59±14 years, 59 male) with structural heart diseases including angina pectoris (n=34), old myocardial infarction (n=15), dilated cardiomyopathy (n=13), hypertrophic cardiomyopathy (n=8), and hypertensive heart disease (n=8) were studied according to the same protocol in 5 university hospitals in Japan. LV mean diastolic pressure (MDP) was measured by using a micromanometer-tipped catheter. Early-diastolic mitral annular velocity (e′) was measured at septal and lateral side of the annulus and averaged, and the ratio of early-diastolic transmitral velocity to e′ (E/e′) was calculated. Global longitudinal strain was measured using STE in 3 apical views and averaged on a frame-by-frame basis to construct a time-strain curve as well as a time-strain rate (SR) curve. Then, the absolute value of peak longitudinal strain (LS), early-diastolic peak SR (LSR E ), and that during isovolumic relaxation (IVR) period (LSR IVR ) were measured. Similarly, peak circumferential strain (CS), early-diastolic peak circumferential SR (CSR E ), and that during IVR (CSR IVR ) were measured from 3 short-axis views. Results: E/e′ weakly correlated with MDP (r=0.50, p&lt;0.001). E/LSR IVR and E/CSR IVR did not correlate with MDP, whereas there was a significant but weak correlation between E/LSR E and MDP (r=0.50, p&lt;0.001) or between E/CSR E and MDP (r=0.41, p&lt;0.001). In contrast, there was a good correlation between E/LS and MDP (r=0.70, p&lt;0.001) or between E/CS and MDP (r=0.62, p&lt;0.001). Especially, the correlation between E/LS and MDP was statistically better than that between E/e′ and MDP (p&lt;0.01). Conclusions: STE-derived longitudinal parameters better correlated with MDP than circumferential parameters. Especially, E/LS was better than E/e′ for estimating LV filling pressure.
Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6
Authors: Susanna Canali, Chia‐Yu Wang, Kimberly B. Zumbrennen‐Bullough, Abraham Bayer, Jodie L. Babitt
Journal: American Journal of Hematology (2017)

Hepcidin is a key iron regulatory hormone that controls expression of the iron exporter ferroportin to increase the iron supply when needed to support erythropoiesis and other essential functions, but to prevent the toxicity of iron excess. The bone morphogenetic protein (BMP)-SMAD signaling pathway, through the ligand BMP6 and the co-receptor hemojuvelin, is a central regulator of hepcidin transcription in the liver in response to iron. Here, we show that dietary iron loading has a residual ability to induce Smad signaling and hepcidin expression in Bmp6-/- mice, effects that are blocked by a neutralizing BMP2/4 antibody. Moreover, BMP2/4 antibody inhibits hepcidin expression and induces iron loading in wildtype mice, whereas a BMP4 antibody has no effect. Bmp2 mRNA is predominantly expressed in endothelial cells of the liver, where its baseline expression is higher, but its induction by iron is less robust than Bmp6. Mice with a conditional ablation of Bmp2 in endothelial cells exhibit hepcidin deficiency, serum iron overload, and tissue iron loading in liver, pancreas and heart, with reduced spleen iron. Together, these data demonstrate that in addition to BMP6, endothelial cell BMP2 has a non-redundant role in hepcidin regulation by iron.
Towards a three-dimensional framework of centrally regulated and goal-directed exercise behaviour: a narrative review
Authors: Andreas Venhorst, Dominic Micklewright, Timothy D Noakes
Journal: British Journal of Sports Medicine (2017)

The Central Governor Model (CGM) ignited a paradigm shift from concepts of catastrophic failure towards central regulation of exercise performance. However, the CGM has focused on the central integration of afferent feedback in homeostatic control. Accordingly, it neglected the important role of volitional self-regulatory control and the integration of affective components inherently attached to all physiological cues. Another limitation is the large reliance on the Gestalt phenomenon of perceived exertion. Thus, progress towards a comprehensive multidimensional model of perceived fatigability and exercise regulation is needed. Drawing on Gate Control Theory of pain, we propose a three-dimensional framework of centrally regulated and goal-directed exercise behaviour, which differentiates between sensory, affective and cognitive processes shaping the perceptual milieu during exercise. We propose that: (A) perceived mental strain and perceived physical strain are primary determinants of pacing behaviour reflecting sensory-discriminatory processes necessary to align planned behaviour with current physiological state, (B) core affect plays a primary and mediatory role in exercise and performance regulation, and its underlying two dimensions hedonicity and arousal reflect affective-motivational processes triggering approach and avoidance behaviour, and (C) the mindset-shift associated with an action crisis plays a primary role in volitional self-regulatory control reflecting cognitive-evaluative processes between further goal-pursuit and goal-disengagement. The proposed framework has the potential to enrich theory development in centrally regulated and goal-directed exercise behaviour by emphasising the multidimensional dynamic processes underpinning perceived fatigability and provides a practical outline for investigating the complex interplay between the psychophysiological determinants of pacing and performance during prolonged endurance exercise.
Abstract #4705: Activation of c-Jun NH2-terminal kinase (JNK) and induction of cytotoxic effect in human lung cancer cells by the small compound oncrasin-60 (NSC-743380)
Authors: Xiaoli Wei, Wei Guo, Shuhong Wu, Li Wang, Yiling Lu, Jinsong Liu, Bingliang Fang
Journal: Cancer Research (2009)

Oncrasin-60 (NSC-743380) is an analogue of oncrasin-1 which we recently identified to be able to induce synthetic lethality with oncogenic K-Ras. Testing on the panel of NCI-60 cancer cell lines derived from various tissues and organs by National Cancer Institute (NCI) Developmental Therapeutics Program showed that oncrasin-60 is highly active against a number of cell lines derived from lung, colon, breast, ovary, and kidney cancers. For a number of sensitive cells, the median 50% growth-inhibitory concentration (GI50) was about 10 nM. To characterize the mechanisms of action, we used reverse-phase protein microarray assay (RPPA) to determine molecular signaling changes induced by oncrasin-60. The sensitive lung cancer cell line H460 was treated with oncrasin-60, harvested overtime, and tested for molecular changes of 77 protein biomarkers by RPPA. The results showed that mitogen-activated protein kinases (MAPK), P38 MAPK, JNK and ERK, were all persistently activated by oncrasin-60 in oncrasin-sensitive cancer cell lines but not in resistant cells. For example, JNK activation in sensitive cells was observed in 30 min after treatment and persisted for at least 15 h. Subsequent study showed that the JNK-specific inhibitor SP600125 effectively blocked the cell killing effect or apoptosis induced by oncrasin-60, whereas inhibitors of P38 MAPK or ERK had not obvious effect. Pretreatment with SP600125 markedly blocked oncrasin-60-induced phosphorylation of JNK and c-JUN. Oncrasin-60 induced cleavages of poly-(ADP-ribose) polymerase (PARP) and caspase-8 were also attenuated in the presence of SP600125. The oncrasin-60-induced apoptosis was also diminished by transfecting sensitive cells with a dominant negative JNK-1. These results demonstrate that sustained JNK activation is critical in oncrasin-60-induced cell death.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4705.
Note on the Transfer of the Strain C3H Milk Influence Through Successive Generations of Strain C Mice
Authors: Howard B. Andervont
Journal: JNCI Journal of the National Cancer Institute (1941)

Note on the Transfer of the Strain C3H Milk Influence Through Successive Generations of Strain C Mice Get access Howard B. Andervont Howard B. Andervont biologist principal National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 3, December 1941, Pages 307–308, https://doi.org/10.1093/jnci/2.3.307 Published: 01 December 1941
Production of Malignancy in Vitro. V. Results of Injections of Cultures into Mice
Authors: Wilton R. Earle, Anderson Nettleship, Edward L. Schilling, Thomas H. Stark, Nancy R. Straus, Mary F. Brown, Emma Shelton
Journal: JNCI Journal of the National Cancer Institute (1943)

Journal Article Production of Malignancy in Vitro. V. Results of Injections of Cultures into Mice Get access Wilton R. Earle, Wilton R. Earle senior cytologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Anderson Nettleship, Anderson Nettleship passed assistant surgeon (R) National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward L. Schilling, Edward L. Schilling technical assistance National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas H. Stark, Thomas H. Stark National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Nancy R. Straus, Nancy R. Straus National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary F. Brown, Mary F. Brown National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Emma Shelton Emma Shelton National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 2, October 1943, Pages 213–227, https://doi.org/10.1093/jnci/4.2.213 Published: 01 October 1943
CARTO guided extensive encircling PV isolation後の左房起源の心房頻拍
Authors: 嶋野祐之, 坪井直哉, 吉田幸彦, 小椋康弘, 鈴木博彦, 山下健太郎, 村松崇, 海野一雅, 松下邦洋
Journal: Circulation (2004)
Effects of Antiretroviral Therapy to Prevent HIV Transmission to Women in Couples Attempting Conception When the Man Has HIV Infection — United States, 2017
Authors: John T. Brooks, Jennifer F. Kawwass, Dawn K. Smith, Dmitry M. Kissin, Margaret Lampe, Lisa B. Haddad, Sheree L. Boulet, Denise J. Jamieson
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Existing U.S. guidelines recommend that men with human immunodeficiency virus (HIV) infection should achieve virologic suppression* with effective antiretroviral therapy (ART) before attempting conception (1). Clinical studies have demonstrated that effective ART profoundly reduces the risk for HIV transmission (2-4). This information might be useful for counseling couples planning a pregnancy in which the man has HIV infection and the woman does not (i.e., a mixed HIV-status couple, often referred to as a serodiscordant couple).
Replication and validation of genetic polymorphisms associated with survival after allogeneic blood or marrow transplant
Authors: Ezgi Karaesmen, Abbas A. Rizvi, Leah M. Preus, Philip L. McCarthy, Marcelo C. Pasquini, Kenan Onel, Xiaochun Zhu, Stephen Spellman, Christopher A. Haiman, Daniel O. Stram, Loreall Pooler, Xin Sheng, Qianqian Zhu, Li Yan, Qian Liu, Qiang Hu, Amy Webb, Guy Brock, Alyssa I. Clay-Gilmour, Sebastiano Battaglia, David Tritchler, Song Liu, Theresa Hahn, Lara E. Sucheston-Campbell
Journal: Blood (2017)
カスタマイズされた生物医学的応用のためのヒアルロン酸とその誘導体【Powered by NICT】
Authors: Kim Hyemin, Jeong Hyeonseon, Han Seulgi, Beack Songeun, Hwang Byung Woo, Shin Myeonghwan, Oh Seung Soo, Hahn Sei Kwang
Journal: Biomaterials (2017)