tbuckley/cabot-search huggingface dataset:
変形性股関節症における構造修飾に対するアボカド-大豆不けん化物(Piascledine)作用の無作為化対照試験: ERADIAS研究
Authors: Maheu Emmanuel, Cadet Christian, Marty Marc, Moyse Dominique, Kerloch Isabelle, Coste Philippe, Dougados Maxime, Mazieres Bernard, Spector Tim D, Halhol Hafid, Grouin Jean-Marie, Lequesne Michel
Journal: Annals of the Rheumatic Diseases (2014)
Association of Efficacy of Resistance Exercise Training With Depressive Symptoms
Authors: Brett R. Gordon, Cillian P. McDowell, Mats Hallgren, Jacob D. Meyer, Mark Lyons, Matthew P. Herring
Journal: JAMA Psychiatry (2018)

<h3>Importance</h3> The physical benefits of resistance exercise training (RET) are well documented, but less is known regarding the association of RET with mental health outcomes. To date, no quantitative synthesis of the antidepressant effects of RET has been conducted. <h3>Objectives</h3> To estimate the association of efficacy of RET with depressive symptoms and determine the extent to which logical, theoretical, and/or prior empirical variables are associated with depressive symptoms and whether the association of efficacy of RET with depressive symptoms accounts for variability in the overall effect size. <h3>Data Sources</h3> Articles published before August 2017, located using Google Scholar, MEDLINE, PsycINFO, PubMed, and Web of Science. <h3>Study Selection</h3> Randomized clinical trials included randomization to RET (n = 947) or a nonactive control condition (n = 930). <h3>Data Extraction and Synthesis</h3> Hedges<i>d</i>effect sizes were computed and random-effects models were used for all analyses. Meta-regression was conducted to quantify the potential moderating influence of participant and trial characteristics. <h3>Main Outcomes and Measures</h3> Randomized clinical trials used validated measures of depressive symptoms assessed at baseline and midintervention and/or postintervention. Four primary moderators were selected a priori to provide focused research hypotheses about variation in effect size: total volume of prescribed RET, whether participants were healthy or physically or mentally ill, whether or not allocation and/or assessment were blinded, and whether or not the RET intervention resulted in a significant improvement in strength. <h3>Results</h3> Fifty-four effects were derived from 33 randomized clinical trials involving 1877 participants. Resistance exercise training was associated with a significant reduction in depressive symptoms with a moderate-sized mean effect ∆ of 0.66 (95% CI, 0.48-0.83;<i>z</i> = 7.35;<i>P</i> &lt; .001). Significant heterogeneity was indicated (total<i>Q</i> = 216.92,<i>df</i> = 53;<i>P</i> &lt; .001;<i>I</i><sup>2</sup> = 76.0% [95% CI, 72.7%-79.0%]), and sampling error accounted for 32.9% of observed variance. The number needed to treat was 4. Total volume of prescribed RET, participant health status, and strength improvements were not significantly associated with the antidepressant effect of RET. However, smaller reductions in depressive symptoms were derived from randomized clinical trials with blinded allocation and/or assessment. <h3>Conclusions and Relevance</h3> Resistance exercise training significantly reduced depressive symptoms among adults regardless of health status, total prescribed volume of RET, or significant improvements in strength. Better-quality randomized clinical trials blinding both allocation and assessment and comparing RET with other empirically supported treatments for depressive symptoms are needed.
Faecalibacterium improves pathogenesis of nonalcoholic steatohepatitis via controlling Treg induced gut-permeability
Authors: T. Kessoku, K. Imajo, Y. Honda, Y. Ogawa, W. Tomeno, M. Yoneda, T. Kato, T. Higurashi, S. Saito, A. Nakajima
Journal: Journal of Hepatology (2018)
Abstract 3309: Repeated Thermal Therapy Mobilizes CD34+ Cells and Improves Peripheral Artery Disease
Authors: Takuro Shinsato, Masaaki Miyata, Takashi Kihara, Tsuyoshi Fukudome, Takuro Kubozono, Yoshiyuki Ikeda, Shuichi Hamasaki, Chuwa Tei
Journal: Circulation (2007)

Background : We developed a form of thermal therapy that differers from the traditional sauna. We reported that repeated thermal therapy upregulated eNOS protein and augmented ischemia-induced angiogenesis in a mouse model of hindlimb ishemia. Furthermore, we demonstrated that repeated thermal therapy improved limb ischemia in patients with peripheral artery disease (PAD). To investigate the underlying mechanism of thermal therapy for the treatment of PAD, we examined whether thermal therapy could mobilize blood-derived progenitor cells for local vascular regeneration. Method : We enrolled 6 patients with PAD and 4 patients with spinal canal stenosis (SCS) as a control. They were treated with a far infrared-ray dry sauna at 60 degrees centigrade for 15 minutes and then kept on bed rest with a blanket for 30 minutes, daily for 6 weeks. The leg pain was scored with a visual analogue scale (10: severest pain, 0: no pain). Ankle-brachial pressure index (ABI) and distance of 6-minute walking were measured before and 6 weeks after repeated thermal therapy. To detect the shift of circulating CD34+ progenitor cells in the periphery with higher sensitivity, we established the use of quantitative real-time polymerase chain reaction (PCR) for CD34 messenger RNA using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene as an internal control. Results : After 6 weeks of thermal therapy, the leg pain score, ABI, and distance of 6- minute walking were significantly improved in patients with PAD, while did not change in patients with SCS. Circulating CD34+ cell numbers were determined biweekly by quantitative real-time PCR before and after the initiation of repeated thermal therapy. In successfully treated patients with PAD, the number of cells increased 1.8-fold from 2.0 ± 1.5 (x10 −4 ) before thermal therapy to 3.6 ± 2.3 (x10 −4 ) after thermal therapy (p=0.018), while the number of cells in patients with SCS was 2.5 ± 0.6 (x10 −4 ) before thermal therapy and 2.5 ± 0.7 (x10 −4 ) after thermal therapy (no significant difference). Conclusion : Repeated thermal therapy mobilized circulating endothelial progenitor cells and improved limb ischemia in patients with PAD. This therapy is a novel, safe, and highly promising strategy for treating PAD.
First concussion did not increase the risk of subsequent concussion when patients were managed appropriately
Authors: Ian Shrier, Alexendre Piché, Russell J Steele
Journal: British Journal of Sports Medicine (2018)

Some studies suggest that having a concussion during athletic activities increases the risk (as expressed through ‘rate ratios’) of subsequent concussion,1 potentially because of incomplete recovery after brain trauma. However, these analyses are flawed for causal interpretation because participants with one concussion likely have different inherent risks compared with those with no concussions.2 The issue is clinically important because patients may decide to return to their sport if their risk of concussion is simply due to the body type, sport and their personal style of play (ie, unchanged compared with prior to the injury) versus being at twice or thrice the risk of the first concussion because the concussion has caused permanent damage.

To address whether a first concussion causally increases the risk of subsequent concussion, we analysed data from Cirque du Soleil (CdS) artists who had two or more concussions.2 3 We provide methodological details in the online supplementary appendix. The analysis in this paper is a matched analysis comparing risk of first concussion to risk of second concussion in the same individuals, thus controlling for different inherent risks similar to case-cross-over designs.4 These matched strategies assume that the increased risk for a …
Case 13-1976
Authors: Carl A. Olsson, Austin L. Vickery
Journal: New England Journal of Medicine (1976)

Presentation of CaseA 35-year-old black man was admitted to the hospital because of hypertension.He was well until 20 years previously, when he was first found to have hypertension. Four years later he was begun on hypotensive medications, but with poor compliance on several regimens. Eight years before entry he received a course of penicillin because of syphilis.Five years before admission the patient was seen at this hospital for evaluation of hypertension. The blood pressure ranged from 150–160/110–120 mm Hg. The results of routine studies, including the creatinine clearance and an intravenous pyelographic examination, were normal except that . . .
Pre-treatment risk stratification in primary biliary cholangitis: a predictive model to guide first-line combination therapy
Authors: M. Carbone, A. Nardi, G. Carpino, M. Heneghan, D. Thorburn, S. Taylor-Robinson, A. Bathgate, M. Zuin, P.M. Battezzati, A. Floreani, E.G. Giannini, M.F. Donato, M. Marzioni, D. Alvaro, L. Miele, F. Marra, H. Ainsworth, L. Muratori, G. Bonato, V. Ronca, L. Cristoferi, D. Stocken, V. Cardinale, G. Hirschfield, G.J.M. Alexander, R. Sandford, D. Jones, P. Invernizzi, G. Mells
Journal: Journal of Hepatology (2018)
Erratum: Corrigendum: Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
Authors: Tianhong Wang, Guilian Niu, Marcin Kortylewski, Lyudmila Burdelya, Kenneth Shain, Shumin Zhang, Raka Bhattacharya, Dmitry Gabrilovich, Richard Heller, Domenico Coppola, William Dalton, Richard Jove, Drew Pardoll, Hua Yu
Journal: Nature Medicine (2004)
Effectiveness of sofosbuvir and ledipasvir/sofosbuvir based regimens in hepatitis C virus genotype 3 infection: real-world data from Georgian hepatitis C elimination program
Authors: T. Tsertsvadze, N. Chkhartishvili, A. Abutidze, L. Sharvadze, V. Kerashvili, G. Kamkamidze, M. Zakalashvili, B. Skaggs, L. Gvinjilia, S. Shadaker, M. Nasrullah, A. Gamkrelidze, V. Kvaratskhelia, S. Zeuzem, N. Afdhal, S. Arora, K. Thornton, F. Averhoff
Journal: Journal of Hepatology (2018)
The anti-inflammatory receptor TREM2 protects the liver from cholestatic injury in mice
Authors: I. Labiano, A. Esparza-Baquer, O. Sharif, P. Milkiewicz, M. Milkiewicz, E. Hijona, R. Jimenez-Aguero, M. Marzioni, D.A. Mann, L. Bujanda, J. Banales, M.J. Perugorria
Journal: Journal of Hepatology (2018)
Responding to Those Who Hope for a Miracle: Practices for Clinical Bioethicists
Authors: Trevor M. Bibler, Myrick C. Shinall, Devan Stahl
Journal: The American Journal of Bioethics (2018)

Significant challenges arise for clinical care teams when a patient or surrogate decision-maker hopes a miracle will occur. This article answers the question, "How should clinical bioethicists respond when a medical decision-maker uses the hope for a miracle to orient her medical decisions?" We argue the ethicist must first understand the complexity of the miracle-invocation. To this end, we provide a taxonomy of miracle-invocations that assist the ethicist in analyzing the invocator's conceptions of God, community, and self. After the ethicist appreciates how these concepts influence the invocator's worldview, she can begin responding to this hope with specific practices. We discuss these practices in detail and offer concrete recommendations for a justified response to the hope for a miracle.
Jimmie C. Holland, MD: In Memoriam (1928–2017)
Authors: David W. Kissane
Journal: Cancer Research (2018)

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On December 24, 2017, the cancer research community lost an internationally acclaimed pioneer of psycho-oncology, Jimmie C. Holland. She had served on the AACR's Program Committee for many years, was Chair of the AACR Task Force on Survivorship Research, and was honored with
TCTAP C-056 PTCA with Stent to Left Main-LAD, LAD (Mid) Lesion with Cutting Edge Buddy Wire Technique, RCA with Thrombus in Patient with Prior Coronary Artery Bypass Graft Surgery and Prior PCI
Authors: Raghav Sharma, Kapil K. Chattree
Journal: Journal of the American College of Cardiology (2018)
Freed, after 15 years in jail for a stillbirth
Authors: Alison Shepherd
Journal: BMJ (2018)

The Center for Reproductive Rights in El Salvador/Oscar Rivera

A Salvadoran woman who said she had had a stillbirth—but who was in prison for nearly 15 years for murdering her child—walks free after the country’s Supreme Court reduced her sentence.

Maira Veronica Figueroa was aged 19 when she was raped and became pregnant, but before reaching full term she …
Physical activity reduces risk of depression at any age, finds study
Authors: Susan Mayor
Journal: BMJ (2018)

Physical activity reduces the risk of developing depression in people of all ages, a large meta-analysis has reported.1

“Our robust analysis of over a quarter of a million people found consistent evidence that people who are more active are less likely to develop depression in the future,” said study author Brendon Stubbs, from the Institute of Psychiatry at King’s College London, UK.

He added, “We found that higher levels of physical activity were protective from …
Fatal Falls Overboard in Commercial Fishing — United States, 2000–2016
Authors: Samantha L. Case, Jennifer M. Lincoln, Devin L. Lucas
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Commercial fishing is one of the most dangerous jobs in the United States, with a 2016 work-related fatality rate (86.0 deaths per 100,000 full-time equivalent workers) 23 times higher than that for all U.S. workers (3.6) (1). Sinking vessels cause the most fatalities in the industry; however, falling from a fishing vessel is a serious hazard responsible for the second highest number of commercial fishing-associated fatalities (2,3). CDC's National Institute for Occupational Safety and Health (NIOSH) analyzed data on unintentional fatal falls overboard in the U.S. commercial fishing industry to identify gaps in the use of primary, secondary, and tertiary prevention strategies. During 2000-2016, a total of 204 commercial fishermen died after unintentionally falling overboard. The majority of falls (121; 59.3%) were not witnessed, and 108 (89.3%) of these victims were not found. Among 83 witnessed falls overboard, 56 rescue attempts were made; 22 victims were recovered but were not successfully resuscitated. The circumstances, rescue attempts, and limited use of lifesaving and recovery equipment indicate that efforts to reduce these preventable fatalities are needed during pre-event, event, and post-event sequences of falls overboard. Vessel owners could consider strategies to prevent future fatalities, including lifeline tethers, line management, personal flotation devices (PFDs), man-overboard alarms, recovery devices, and rescue training.
Safety of Programmed Death–1 Pathway Inhibitors Among Patients With Non–Small-Cell Lung Cancer and Preexisting Autoimmune Disorders
Authors: Giulia C. Leonardi, Justin F. Gainor, Mehmet Altan, Sasha Kravets, Suzanne E. Dahlberg, Lydia Gedmintas, Roxana Azimi, Hira Rizvi, Jonathan W. Riess, Matthew D. Hellmann, Mark M. Awad
Journal: Journal of Clinical Oncology (2018)

Purpose Although programmed death (PD)-1 pathway inhibitors are now used in nearly all patients with advanced non-small-cell lung cancer (NSCLC), the large number of patients with NSCLC and concurrent autoimmune disease (AID) have been universally excluded from immunotherapy clinical trials. Therefore, the safety of PD-1 and PD-ligand 1 (PD-L1) inhibitors in patients with NSCLC and underlying AID is currently unknown. Methods As part of a multi-institutional effort, we retrospectively collected clinicopathologic data from patients with NSCLC and a history of AID who received monotherapy with either a PD-1 or a PD-L1 (herein referred to as PD-[L]1) inhibitor. Qualifying AIDs included but were not limited to: rheumatologic, neurologic, endocrine, GI, and dermatologic conditions. Results We identified 56 patients with NSCLC and an AID who received a PD-(L)1 inhibitor. At the time of treatment initiation, 18% of patients had active AID symptoms and 20% were receiving immunomodulatory agents for their AID. A total of 55% of patients developed an AID flare and/or an immune-related adverse event (irAE). Exacerbation of the AID occurred in 13 patients (23% of the whole cohort), four of whom required systemic corticosteroids. Immune-related adverse events occurred in 21 patients (38%). Among irAEs, 74% were grade 1 or 2 and 26% were grade 3 or 4; eight patients required corticosteroids for irAE management. PD-(L)1 therapy was permanently discontinued in eight patients (14%) because of irAEs. The overall response rate to immunotherapy in this population was 22%. Conclusion In patients with NSCLC with AID treated with a PD-(L)1 inhibitor, exacerbation of AID occurred in a minority of patients. The incidence of irAEs was similar to reported rates in clinical trials where patients with AID were excluded. Adverse events were generally manageable and infrequently led to permanent discontinuation of immunotherapy.
Cu isotope ratio shifts in common bile duct ligated mice and correlates with the degree of cholestatic-induced liver disease
Authors: S.V. Campenhout, M. Costas-Rodríguez, A.A.M.B. Hastuti, S. Raevens, A. Geerts, X. Verhelst, F. Vanhaecke, H.V. Vlierberghe, L. Devisscher
Journal: Journal of Hepatology (2018)
QOL-04. LONGITUDINAL ASSESSMENT OF ATAXIA IN CHILDREN FOLLOWING SURGICAL RESECTION OF POSTERIOR FOSSA TUMOURS
Authors: Helen Hartley, Barry Pizer, Steven Lane, Lisa Bunn, Bernie Carter, Elizabeth Cassidy, Ram Kumar
Journal: Neuro-Oncology (2018)

To report the natural history of ataxia in the first two years following surgical resection of a posterior fossa tumour (PFT). 20 children (mean age 9.9 years, range 5-15 years) who had undergone resection of a posterior fossa tumour were assessed using the Scale for the Assessment and Rating of Ataxia (SARA), Brief Ataxia Rating Scale (BARS) and the Pediatric Evaluation of Disability Index (PEDI) at the following time points; initial post-operative period, then at 3 months, 1 and 2 years post operatively. The assessments demonstrated a rapid improvement in ataxia between initial and 3 months post-operative assessments, quantified by both the SARA and BARS (mean reduction in scores 4.8, 4.6 respectively). There were additional gradual improvements at 1 year (mean reduction SARA 0.6, BARS 0.2) and 2 years post operatively (mean reduction SARA 0.9, BARS 0.9). Return of function behaved similarly, quantified by a rapid increase in PEDI scores between initial and 3 month assessments (mean increase in score 26) and gradual increases at 1 and 2 years (mean increase 2, 2.5 respectively). There was a trend for children with medulloblastoma to demonstrate higher ataxia scores than children with low grade gliomas (mean initial post-operative scores 13.4 and 8.5 respectively). The largest change in ataxia scores and functional mobility scores (PEDI) is demonstrated within the first 3 months post operatively. Ongoing gradual improvement in ataxia and mobility function was observed at 2 years. These results have implications for management of children with PFT.
Additional Risk Factors for Breast Implant–Associated Anaplastic Large Cell Lymphoma—Reply
Authors: Ashley N. Leberfinger, Donald R. Mackay, Dino J. Ravnic
Journal: JAMA Surgery (2018)

In Reply We thank Altundag and Fleury for their interest in our article.1 The pathogenesis of this rare disease entity is still under investigation. However, all cases with detailed implant history have been linked to textured implants.
International consensus report on the diagnosis and management of rhinitis
Authors: VJ Lund, A Aaronson, J Bousquet, R Dahl, RJ Davies, R Gerth van Wijk, K Holmberg, E Juniper, IS MacKay, L Malm, N Mygind, M Okuda, C Ortolani, HM Schanker, SL Spector, Paul Van Cauwenberge, Wayoff
Journal: Allergy (1994)
ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein)
Authors: Yohann Rautureau, Vanessa Deschambault, Marie-Ève Higgins, Daniel Rivas, Mélanie Mecteau, Pascale Geoffroy, Géraldine Miquel, Kurunradeth Uy, Rocio Sanchez, Véronique Lavoie, Geneviève Brand, Audrey Nault, Pierre-Marc Williams, Maria Laura Suarez, Nolwenn Merlet, Line Lapointe, Natacha Duquette, Marc-Antoine Gillis, Samaneh Samami, Gaétan Mayer, Philippe Pouliot, Adeline Raignault, Foued Maafi, Mathieu R. Brodeur, Sylvie Levesque, Marie-Claude Guertin, Marie-Pierre Dubé, Éric Thorin, David Rhainds, Éric Rhéaume, Jean-Claude Tardif
Journal: Circulation (2018)

Background: Pharmacogenomic studies have shown that ADCY9 genotype determines the effects of the CETP (cholesteryl ester transfer protein) inhibitor dalcetrapib on cardiovascular events and atherosclerosis imaging. The underlying mechanisms responsible for the interactions between ADCY9 and CETP activity have not yet been determined. Methods: Adcy9 -inactivated ( Adcy9 Gt/Gt ) and wild-type (WT) mice, that were or not transgenic for the CETP gene (CETPtg Adcy9 Gt/Gt and CETPtg Adcy9 WT ), were submitted to an atherogenic protocol (injection of an AAV8 [adeno-associated virus serotype 8] expressing a PCSK9 [proprotein convertase subtilisin/kexin type 9] gain-of-function variant and 0.75% cholesterol diet for 16 weeks). Atherosclerosis, vasorelaxation, telemetry, and adipose tissue magnetic resonance imaging were evaluated. Results: Adcy9 Gt/Gt mice had a 65% reduction in aortic atherosclerosis compared to WT ( P &lt;0.01). CD68 (cluster of differentiation 68)-positive macrophage accumulation and proliferation in plaques were reduced in Adcy9 Gt/Gt mice compared to WT animals ( P &lt;0.05 for both). Femoral artery endothelial-dependent vasorelaxation was improved in Adcy9 Gt/Gt mice (versus WT, P &lt;0.01). Selective pharmacological blockade showed that the nitric oxide, cyclooxygenase, and endothelial-dependent hyperpolarization pathways were all responsible for the improvement of vasodilatation in Adcy9 Gt/Gt ( P &lt;0.01 for all). Aortic endothelium from Adcy9 Gt/Gt mice allowed significantly less adhesion of splenocytes compared to WT ( P &lt;0.05). Adcy9 Gt/Gt mice gained more weight than WT with the atherogenic diet; this was associated with an increase in whole body adipose tissue volume ( P &lt;0.01 for both). Feed efficiency was increased in Adcy9 Gt/Gt compared to WT mice ( P &lt;0.01), which was accompanied by prolonged cardiac RR interval ( P &lt;0.05) and improved nocturnal heart rate variability ( P =0.0572). Adcy9 inactivation–induced effects on atherosclerosis, endothelial function, weight gain, adipose tissue volume, and feed efficiency were lost in CETPtg Adcy9 Gt/Gt mice ( P &gt;0.05 versus CETPtg Adcy9 WT ). Conclusions: Adcy9 inactivation protects against atherosclerosis, but only in the absence of CETP activity. This atheroprotection may be explained by decreased macrophage accumulation and proliferation in the arterial wall, and improved endothelial function and autonomic tone.
Pan-genotypic loop-mediated isothermal amplification assay for HBV: a simple, rapid and affordable point-of-care test to semi-quantify HBV DNA
Authors: J. Vanhomwegen, A. Kwasiborski, V. Sauvage, L. Boizeau, D. Hoinard, D. Candotti, S. Laperche, Y. Shimakawa
Journal: Journal of Hepatology (2018)
DOUBLE BALLOON ASSISTED ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP) IN PATIENTS WITH ROUX-EN-Y ANASTOMOSIS
Authors: LE Zamora Nava, AL Miranda Lora, G Grajales-Figueroa, AI Ramírez Polo, F Valdovinos Andraca
Journal: Endoscopy (2018)

Evaluate outcomes and safety of double balloon assisted endoscopic retrograde cholangiopancreatography in patients with Roux-en-Y anastomosis.