tbuckley/cabot-search huggingface dataset:
Additive effect between prenatal depression and transepidermal water loss on atopic dermatitis via Th2 immune responses: COCOA study
Authors: Mi-young Lee, Dr.So-Yeon Lee, Si Hyeon Lee, Ji-Sun Yoon, Sungsu Jung, Hyun-ju Cho, Dong In Suh, Youn Ho Shin, Kyung Won Kim, Kangmo Ahn, Kyung-Sook Lee, Yee-Jin Shin, Soo-Jong Hong
Journal: Journal of Allergy and Clinical Immunology (2018)
Are there any guidelines for internal locum pay (registrar grade) to cover colleagues' absence from work? We seem to be paid less for internal locum on-calls than for our normal or regular on-calls.
Authors: Simon Eccles
Journal: BMJ (2004)

<i>Got a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone (www.bmjcareers.com/advicezone) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site.</i>
Inhibitory Effect of Rabbit Bile on Renin Angiotensinogen Reaction System
Authors: Kunio Hiwada, Tatsuo Kokubu, Yuichi Yamamura
Journal: Circulation (1970)

It was found that native bile from rabbit had a potent inhibitory effect on renin angiotensinogen reaction in vitro. This inhibitory effect of rabbit bile on angiotensin formation was shown to be attributable to both renin inhibitory active principle and renin substrate inactivating substanoe. Renin inhibitory active principle in bile was obtained in the fraction of the precipitate of 40% ammonium sulfate saturation and was heat-stable. The active principle differed from lysophospholipid renin inhibotor. It probably differed from heparin.
Increasing physician recognition and management of immune-mediated adverse events (imAEs): Results of a structured learning platform.
Authors: Zeshaan Rasheed, Caius Kim, Eugene Vissers, Aviva G. Asnis-Alibozek, Scott Joseph Antonia
Journal: Journal of Clinical Oncology (2018)

211 Background: Immunotherapies have significantly improved cancer outcomes across multiple tumor types, while concurrently introducing new and unique toxicities, requiring timely recognition and intervention. To advance physician knowledge of imAEs, an educational online platform was developed for use by AstraZeneca clinical trial investigators (PIs). Herein, we report the impact of this educational strategy on PIs’ knowledge and confidence in recognizing and managing imAEs. Methods: The web-based learning platform included 8 structured and interactive modules (mode of action, colitis, pneumonitis, rash, hepatitis, endocrinopathy, neurotoxicity and nephritis), each containing 3 lessons reviewing background, pathophysiology and diagnosis of individual imAEs, management strategies and expert videos. Pre- and post-training questions to test knowledge (n = 5) and confidence (n = 2) were offered. The platform launched in May 2016 and remains active. PIs participating in durvalumab and/or tremelimumab clinical trials are eligible for participation. Results: As of Jan 19 2017, 2372 PIs have been invited to participate, 356 accessed the platform, and 294 completed ≥1 lesson (57% mode of action, 62% colitis, 42% pneumonitis, 20% rash, 24% hepatitis, 18% endocrinopathy, 19% neurotoxicity, 15% nephritis). Although an overall high proportion of correctly answered questions was identified at the pre-training stage (73% of 2935 total questions, n = 169 PIs), accuracy increased by a mean of 11% (range -3‒27%) at the post-training stage (84%). In each module, there was ≥1 question (range 1‒3) for which correct answers increased by ≥15% post- vs pre-training. Overall, after learning, confidence levels in recognition and management of imAEs increased by 28% (57 to 85%, p &lt; 0.05; n = 35‒102 PIs) and 28% (51 to 79%, p &lt; 0.05; n = 28‒101 PIs), respectively. Conclusions: The number of PIs completing ≥1 lesson indicates a desire for imAE training. This educational initiative enhanced knowledge, and among PIs with suboptimal confidence pre-training, 1 in 2 reported increased confidence in imAE recognition and management, which may improve patient care and maximize treatment potential.
*How Life Is
Authors: Carol Snyder Halberstadt
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy of an over-the-scope clip for preventing adverse events after duodenal endoscopic submucosal dissection: a prospective interventional study
Authors: Tomoaki Tashima, Ken Ohata, Eiji Sakai, Yoshitsugu Misumi, Maiko Takita, Yohei Minato, Yasushi Matsuyama, Takashi Muramoto, Hitoshi Satodate, Hajime Horiuchi, Nobuyuki Matsuhashi, Kouichi Nonaka, Shomei Ryozawa
Journal: Endoscopy (2018)

Abstract Background Duodenal endoscopic submucosal dissection (ESD) remains technically challenging, with a high risk of severe adverse events. Because exposure of the duodenal post-ESD mucosal defect to pancreatic juice and bile acid reportedly induces delayed perforation and bleeding, we examined whether defect closure using an over-the-scope clip (OTSC) system was useful for preventing postoperative adverse events. Methods From April 2016 to February 2017, a total of 50 consecutive patients with superficial non-ampullary duodenal epithelial tumors (SNADETs) larger than 10 mm, with no more than semi-circumferential spread, were prospectively enrolled in this study. All of the lesions were treated by experienced ESD operators and the post-ESD mucosal defect was closed using OTSCs. Results All of the SNADETs were completely removed by ESD, with an R0 resection rate of 88.0 %. The mean procedure and closure times were 67.3 ± 58.8 minutes and 9.8 ± 7.2 minutes, respectively. Although complete defect closure was achieved in 94.0 % of the patients (47/50), two patients required surgical conversion. Delayed perforation occurred in only one patient (2.1 %), who did not have successful closure of the defect, as misplacement of the OTSC exposed the muscle layer. Meanwhile, delayed bleeding occurred in three patients (6.3 %); however, the bleeding was easily controlled using endoscopic coagulation. The mean duration of postoperative hospitalization was 5.5 ± 7.2 days. Conclusions Prophylactic defect closure using OTSCs may be effective in reducing severe adverse events after duodenal ESD.
Patient-Centered Outcomes and Resuscitation Fluids
Authors: John Myburgh
Journal: New England Journal of Medicine (2018)

During the past 50 years, the use of intravenous resuscitation fluids in critically ill patients has been based on physiological principles rather than on evidence from clinical trials.1 None of the current proprietary resuscitation fluids have been formally evaluated for safety and efficacy, and only a handful of the other drugs commonly used in acute care, such as vasopressors, antiarrhythmic drugs, and antibiotics, have been formally evaluated for efficacy and safety despite their established roles in clinical practice. In the past decade, results from randomized, controlled trials have shown that the type of resuscitation fluid used in critically ill patients . . .
INCREMENTAL VALUE OF SPECTRAL DETECTOR CT USING LOW-CONTRAST FOR PRE-TAVR CT ANGIOGRAPHY
Authors: Amer Alaiti, Steven Van Hedent, Anas Fares, Rahul Thomas, Ahmad Alkhalil, Nils Grosse HoKamp, Sandeep Patel, Riki Kessner, Amar Dhanantwar, Mani Vembar, Pablo Ros, David Wilson, Mani Vembar, Robert Gilkeson, Sanjay Rajagopalan, Guilherme Attizzani, Hiram Bezerra
Journal: Journal of the American College of Cardiology (2018)
Doctors should undergo manual handling training
Authors: Rachel Hooke
Journal: BMJ (2006)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Doctors should undergo manual handling training Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Pharmacologic inhibition of STAT5 in acute myeloid leukemia
Authors: Bettina Wingelhofer, Barbara Maurer, Elizabeth C. Heyes, Abbarna A. Cumaraswamy, Angelika Berger-Becvar, Elvin D. de Araujo, Anna Orlova, Patricia Freund, Frank Ruge, Jisung Park, Gary Tin, Siawash Ahmar, Charles-Hugues Lardeau, Irina Sadovnik, Dávid Bajusz, György Miklós Keserű, Florian Grebien, Stefan Kubicek, Peter Valent, Patrick T. Gunning, Richard Moriggl
Journal: Leukemia (2018)

The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK driving the pathogenesis of acute myeloid leukemia (AML). Since STAT5 is a critical mediator of diverse malignant properties of AML cells, direct targeting of STAT5 is of significant clinical value. Here, we describe the development and preclinical evaluation of a novel, potent STAT5 SH2 domain inhibitor, AC-4-130, which can efficiently block pathological levels of STAT5 activity in AML. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. Notably, AC-4-130 substantially impaired the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo. Furthermore, AC-4-130 synergistically increased the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol. Overall, the synergistic effects of AC-4-130 with TK inhibitors (TKIs) as well as emerging treatment strategies provide new therapeutic opportunities for leukemia and potentially other cancers.
Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme
Authors: Sze Kiat Tan, Chiara Pastori, Clara Penas, Ricardo J. Komotar, Michael E. Ivan, Claes Wahlestedt, Nagi G. Ayad
Journal: Molecular Cancer (2018)

Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary brain tumor. Despite surgical resection followed by radiotherapy and chemotherapy, the median survival rate is approximately 14 months. Although experimental therapies are in clinical trials for GBM, there is an urgent need for a peripheral GBM biomarker for measuring treatment response. As we have previously demonstrated that the long noncoding RNA HOX Transcript Antisense Intergenic RNA, or HOTAIR, is dysregulated in GBM and required for GBM cell proliferation, we hypothesized that HOTAIR expression may be utilized as a peripheral biomarker for GBM. HOTAIR expression was measured in serum from 43 GBM and 40 controls using quantitative real-time PCR (qRT-PCR). The PCR products were subsequently subcloned into pCR™4-TOPO®TA vectors for DNA sequencing. A ROC curve was also generated to examine HOTAIR’s prognostic value. The amount of HOTAIR in serum exosomes and exosome-depleted supernatant was calculated by qRT-PCR. The relative HOTAIR expression was also investigated in 15 pairs of GBM serum and tumors. We detected HOTAIR in serum from GBM patients. HOTAIR levels in serum samples from GBM patients was significantly higher than in the corresponding controls (P < 0.0001). The area under the ROC curve distinguishing GBM patients from controls was 0.913 (95% CI: 0.845–0.982, P < 0.0001), with 86.1% sensitivity and 87.5% specificity at the cut-off value of 10.8. HOTAIR expression was significantly correlated with high grade brain tumors. In addition, Pearson correlation analysis indicated a medium correlation of serum HOTAIR levels and the corresponding tumor HOTAIR levels (r = 0.734, P < 0.01). We confirmed via sequencing that the amplified HOTAIR from serum contained the HOTAIR sequence and maps to the known HOTAIR locus at 12q13. The serum-derived exosomes contain HOTAIR and the purified exosomes were validated by western blot and nanoparticle tracking analysis. Importantly, our results demonstrate that serum HOTAIR can be used as a novel prognostic and diagnostic biomarker for GBM.
Scottish GPs call for end to “unsustainable” workload and support move towards separate GP contract
Authors: Abi Rimmer
Journal: BMJ (2014)

GPs in Scotland face increasing workload pressures and difficulties in recruiting, the chairman of the BMA’s General Practitioners Committee for Scotland has said.

Alan McDevitt said that workload, recruitment, and retention were among the main concerns raised by GPs at the Scottish local medical committees’ conference in Glasgow last week. GPs also backed a motion calling for a “Scottish” GP contract.

Speaking to BMJ Careers after the conference, McDevitt said, “To be honest, GPs are pretty much on the edge, and I think we’re going to have real problems keeping young doctors in general practice, and keeping old ones as well. People who are [currently] GPs …
Older appraisers are more lenient when assessing feedback, researchers find
Authors: Abi Rimmer
Journal: BMJ (2016)

Older appraisers were more lenient when assessing feedback from patients and colleagues, researchers have found.

The research, published in the British Journal of General Practice , found that older GP appraisers tended to be more lenient than younger appraisers when interpreting multisource feedback (MSF).1 MSF on a doctor’s practice is obtained from colleagues and patients as …
Functional Outcome After Intracranial Presuure Monitoring—Reply
Authors: Tellen D. Bennett, Tom H. Greene, Heather T. Keenan
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Late life crisis
Authors: Richard Sturge
Journal: BMJ (2004)

After 26 years as a north London rheumatologist, it dawned on me that retirement was only two years away. Then what? Proust, Open University, and more time with Radio 4 didn't hold much appeal. Neither did locum work. Even my passion for climbing mountains had palled as I found I could no longer keep up with the “young.” But my concerns were less about fading physical prowess than declining mental agility. Was I still capable of learning?

So last August, with the cautious connivance of my wife, I tested the water by leaving my NHS post and enrolling on a three month course in tropical medicine. I was terrified that I might not be able to stand the pace, but I soon relaxed in the company of the finest bunch of people I've ever worked with, most of them half my age. I was almost prostrate with fear about the exam (the first I had sat for more than 30 years), despite rumours that nobody had actually failed it since 1999. I remain …
Abstract P2-09-26: Frequency and mechanisms of elevated somatic mutation burden in metastatic breast cancer and response to immune checkpoint blockade
Authors: EF Cobain, DR Robinson, Y-M Wu, R Lonigro, P Vats, E Rabban, C Kumar-Sinha, AF Schott, JB Smerage, A Morikawa, ML Burness, CH Van Poznak, J Griggs, M Wicha, DF Hayes, AM Chinnaiyan
Journal: Cancer Research (2018)

Abstract Background: Immune checkpoint blockade (ICB) is effective in the treatment of various malignancies. Thus far, however, results in breast cancer have been mixed. Elevated tumor mutational load, and subsequent increased likelihood of forming immunogenic neoantigens, has been correlated with response to ICB. Mutational load observed in breast cancers varies widely. However, most studies have assessed mutational load using primary tumors. Few studies have explored the frequency of high mutational load, molecular mechanisms accounting for this phenomenon, and its potential impact on response to ICB in metastatic breast cancer (MBC). Methods: From 2011-2016, 124 patients (pts) with MBC of varying subtypes underwent research biopsy of their metastatic disease for whole genome, exome and transcriptome sequencing of tumor and matched normal sample through the Michigan Oncology Sequencing Center (Mi-OncoSeq). Those pts with elevated somatic mutation load were defined as having greater than 10 mutations per megabase of targeted sequencing and mutational signatures accounting for high mutation load were noted. Pts treated subsequently with ICB were followed to assess response. Results: Twelve MBC pts had high mutation load (10% of cohort). Eight pts had estrogen receptor (ER) positive MBC and 4 pts had metastatic triple negative breast cancer (TNBC). In 5 cases, a clear mutational signature accounting for high mutation load was evident. Two TNBC cases harbored an APOBEC mutational signature in addition to 1 TNBC and 2 ER positive tumors displaying a microsatellite instability signature (MSI-H). Among the tumors with MSI-H signature, 1 case was associated with a pathogenic germline alteration in MLH1. Two pts were subsequently treated with ICB on a clinical trial. One pt came off study after 3 months due to progressive brain metastases and another had partial response to therapy lasting 7 months. Conclusions: Elevated somatic mutation burden in MBC is observed in approximately 10% of pts, and is detected in both ER positive and TNBC. Since high mutation burden has been associated with increased likelihood of response to ICB, identification of this genomic feature could have important therapeutic implications for MBC pts. Citation Format: Cobain EF, Robinson DR, Wu Y-M, Lonigro R, Vats P, Rabban E, Kumar-Sinha C, Schott AF, Smerage JB, Morikawa A, Burness ML, Van Poznak CH, Griggs J, Wicha M, Hayes DF, Chinnaiyan AM. Frequency and mechanisms of elevated somatic mutation burden in metastatic breast cancer and response to immune checkpoint blockade [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P2-09-26.
Detection of KRAS mutation, MSI and TP53 status in Indonesian CRC patients with its association to PD-L1 expression
Authors: G.D. Kusumo, T.P. Putra, A.D. Budiyati, F. Rexana, A. Sudoyo, A.N. Kurniawan, A.R. Utomo, A. Utama
Journal: Annals of Oncology (2018)
Antigen‐Free Radionuclide‐Embedded Gold Nanoparticles for Dendritic Cell Maturation, Tracking, and Strong Antitumor Immunity
Authors: Sang Bong Lee, Young Ju Lee, Sung Jin Cho, Sang Kyoon Kim, Sang‐Woo Lee, Jaetae Lee, Dong‐Kwon Lim, Yong Hyun Jeon
Journal: Advanced Healthcare Materials (2018)

Abstract Dendritic cell (DC)‐based cancer immunotherapy requires efficient maturation of DCs and sensitive monitoring of DCs localized in the lymph nodes that activate T cells. This paper reports a robust and simple surface chemistry for highly sensitive and stable radionuclide‐embedded gold nanoparticles (Poly‐Y‐RIe‐AuNPs) prepared with oligotyrosine‐modified AuNPs with additional Au shell formation as a promising positron emission tomography/computed tomography imaging agent. The multiple oligotyrosine binding sites modified on AuNPs provide excellent stability for conjugated radioisotopes by forming an Au shell. They can be heavily conjugated with radioisotope iodine, which enables sensitive tracking of DCs in the lymphatic system. More importantly, it is found that the maturation of DCs is possible solely with Poly‐Y‐RIe‐AuNPs without any additional stimulus for DC maturation. DCs matured by Poly‐Y‐RIe‐AuNPs induce antitumor immunity to cervical cancer comparable to that produced from DCs pulsated with tumor lysates. These results demonstrate that the peptide‐based surface chemistry of Poly‐Y‐RIe‐AuNPs is a simple and straightforward method to produce a highly sensitive and stable nuclear medicine imaging agent that also improves the efficiency of current antitumor immunotherapies.
DH will consider juniors’ rejection of new contract, Hunt says
Authors: Abi Rimmer
Journal: BMJ (2016)

The Department of Health for England will consider the outcome of a BMA ballot on the proposed new contract for junior doctors, the health secretary has said.

On Tuesday 5 July the BMA announced that 58% of junior doctors who took part in the ballot had voted to reject the proposals for a new contract. The ballot received responses from 37 000 junior doctors and medical students, a 68% response rate.1 After the result …