tbuckley/cabot-search huggingface dataset:
THU0726-HPR What characterises patients referred for surgical consultation due to carpometacarpal osteoarthritis?
Authors: EMH Gravas, R Nossum, REM Eide, A Klokkereide, KH Matre, M Olsen, S Darre, O Andreassen, N Osteras, I Kjeken
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Carpometacarpal osteoarthritis (CMC-OA) is a common joint condition, with a prevalence of 13% in people aged 41 to 50 years, increasing to 68% in people between 71 and 80 years. In the absence of disease-modifying interventions, non-pharmacological approaches are considered as core treatments for hand OA, while surgery is recommended for those with severe CMC-OA. <h3>Objectives</h3> To describe function and previous treatment in patients referred for surgical consultation due to CMC-OA. <h3>Methods</h3> Individuals referred for surgical consultation due to their CMC-OA at three Norwegian departments of rheumatology were invited to participate. Those who agreed attended a clinical assessment and reported their symptoms, disability and function using validated outcome measures including the Quick-Dash (0–100, 0=no disability) and the MAPHand (1–4, 1=no limitations). <h3>Results</h3> A total of 180 patients (mean age 63, range: 45 to 82; 79% women) were included. Thirty-six percent were referred for right hand, 43% for left hand, and 21% for bilateral surgery. Concerning previous treatment for hand OA, 21% (78% women) had received hand surgery, 22% (81% women) physical or occupational therapy, and 11% (95% women) had consulted a rheumatologist. Women consistently reported higher pain levels compared to men, had more finger joints with bony enlargements and significantly lower grip and pinch strength in both hands (Table). They also reported significantly more disability and activity limitations at Quick Dash; 38.6 versus 30.4, (p=0.006) and MAPHand; 2.0 versus 1.7 (p&lt;0.001), for women and men, respectively. However, for finger range of motion, men had slightly more flexion deficit and less palmar abduction in their left hand compared to women. <h3>Conclusions</h3> Among patients referred for surgical consultation due to CMC-OA, women self-reported lower hand function and scored poorer than men in observer based assessments. Even if conservative treatment is recommended before referral for surgery, only a few participants had received such treatment for their hand OA. <h3>Disclosure of Interest</h3> None declared
AB0632 Assessment of vegf and other cytokines in the tear of patients with systemic sclerosis
Authors: A Rentka, J Hársfalvi, K Köröskényi, G Szücs, Z Szekanecz, P Szodoray, A Berta, Ά Kemény-Beke
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Systemic sclerosis (SSc) is an autoimmune disease, characterized by widespread small vessel vasculopathy, immune dysregulation with production of autoantibodies, and progressive fibrosis. SSc may be associated with sicca syndrome. Changes in levels of proangiogenic and proinflammatory cytokines had already been determined largely in serum, however, the local inflammatory and cytokine milieu in the tear of SSc patients has not yet been evaluated. <h3>Objectives</h3> We wished to determine VEGF and other cytokine and chemokine levels in tear samples of SSc patients. <h3>Methods</h3> First, forty-three patients (40 female and 3 men, mean (SD) age 61 (48–74) years) with SSc and 27 healthy controls were enrolled in the VEGF study. Basal tear sample collection and tear velocity investigations were carried out followed by an ophthalmological examination. Total protein concentrations and VEGF levels were determined in tear samples. In the multiple cytokine study, unstimulated tear samples were collected from nine patients with SSc and 12 age- and gender-matched healthy controls. The relative levels of 102 different cytokines were determined by a cytokine array, and then absolute levels of four key cytokines were determined by a magnetic bead assay. <h3>Results</h3> In the first study, the mean collected tear fluid volume developed 10.4 L (1.6–31.2) in patients and 15.63 L (3.68–34.5) in control subjects. The mean total protein level was 6.9 g/L (1.8–12.3) and 4.1 g/L (0.1–14.1) in tear samples of SSc patients and controls, respectively. In patients with SSc, the mean VEGF tear concentration was 4.9 pg/L (3.5–8.1) compared to 6.15 pg/L (3.84–12.3) in healthy samples. Multicytokine-array studies revealed shifted cytokine profile characterized by predominance of proinflammatory mediators in the tear samples of SSc patients. Out of the 102 analyzed proteins, nine were significantly increased in tears of patients with SSc. Based on the multiplex bead results, CRP, interferon-inducible protein 10 (IP-10) and monocyte chemoattractant protein-1 (mcp-1) levels were significantly higher in tears of patients with SSc compared to controls. <h3>Conclusions</h3> Impaired angiogenesis has been found by other investigators in SSc. This is reflected by lower VEGF levels in the tear samples of SSc patients compared to controls. The multi-cytokine array study revealed increased production of CRP and two important pro-inflammatory chemokines in the tear of SSc patients. Our current data depict a group of inflammatory mediators, which may play a significant role in ocular pathology of SSc. <h3>Disclosure of Interest</h3> None declared
Mental health services turned down help for 50 000 young people in England last year, report estimates
Authors: Zosia Kmietowicz
Journal: BMJ (2017)

Children and adolescents in England face barriers when seeking help for mental health problems, with access and waiting times for treatment varying across the country, a report by the think tank the Education Policy Institute has found.1 The institute sent freedom of information requests to all 67 providers of child and adolescent mental health …
Introduction: Session VIII
Authors: C. C. Little
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Introduction: Session VIII Get access C. C. Little C. C. Little Chairman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 3, December 1954, Pages 813–816, https://doi.org/10.1093/jnci/15.3.813 Published: 01 December 1954
FRI0453 Clinical and therapeutic characterization of a colombian cohort with spondyloarthropathies
Authors: MA Alzate, F Ramirez, F Vargas, D Hernandez-Parra, JC Salazar-Uribe, P Ortiz-Salazar, R Pineda
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Spondyloarthropathies (SpAs) are a group of auto-inflammatory diseases, with overlapping symptoms, that include ankylosing spondylitis (AS), psoriatic arthritis (PsA), undifferentiated spondyloarthritis (Und SpA), enteropathic arthritis, and reactive arthritis (1). <h3>Objectives</h3> To characterize the disease in a large Colombian cohort with SpAs, assessing differences in its classification, clinical manifestations, laboratory results, radiographic changes, and treatment, according to the type of SpA. <h3>Methods</h3> A cross-sectional study was conducted in 621 patients with SpAs, in whom sociodemographic, clinical and therapeutic characteristics were analyzed based on the type of diagnosis. Statistical association was examined by means of Chi-square tests, Fisher9s exact test, Mann-Whitney test, and logistic regression analyses. In all cases, a p value &lt;0.05 was considered significant. <h3>Results</h3> Out of the 621 patients included, AS was observed in 54,7%, PsA in 35,7%, and Und SpA in 9,5%. AS was positively associated to male gender (OR 2.05 95%IC 1.5–2.8), younger age at onset, axial involvement (OR 23.2 95%IC 15.2–35.5), uveitis (OR 3.8 95%IC 2.25–6.57), radiographic sacroilitis (OR 6.95 95%IC 3.02–16.02), and HLA-B27 positivity (OR 2.3 95%IC 1.5- 3.5). PsA was associated to female gender, older age at onset, arthritis, and peripheral involvement. According to the therapeutic approach, more use of conventional DMARD therapy was found in PsA and Und SpA, while more use of biology therapy in AS. <h3>Conclusions</h3> To our knowledge, this is the larger existing cohort with SpAs in Colombia. Understanding the natural history of disease is important to do an early diagnosis and treatment that could prevent irreversible disability. <h3>References</h3> Ehrenfeld M. Spondyloarthropathies. Best Pract Res Clin Rheumatol. 2012;26(1):135–45. <h3>Acknowledgements</h3> None. <h3>Disclosure of Interest</h3> None declared
THU0662 Comparing electronic collection of patient reported outcomes at home versus touch-screens in the waiting area among patients with arthritis in clinical practice: a randomised agreement study with online recruitment using danbio
Authors: AE Secher, B Glintborg, H Gudbergsen, NS Krogh, DV Jensen, IJ Sørensen, R Christensen, M Skougaard, ML Hetland
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Collection of patient-reported outcomes (PROs) is an important aspect of modern treatment strategies. Electronic capture in waiting areas by touch screens is part of routine care in the Danish DANBIO registry<sup>1</sup>. It is not known whether this data collection can be replaced with electronic data entry from home. <h3>Objectives</h3> To test the feasibility of online patient recruitment via touch screens and to investigate if electronic reporting of PROs from home (ELECTOR IT-platform) is comparable to reporting completed at the hospital among patients with rheumatoid arthritis (RA) or axial spondyloarthritis (AS). <h3>Methods</h3> Patients with RA or AS were recruited via touch screens and randomized to one of two groups by a pre-computed list generated through DANBIO; the first group completing the PROs at home and then at the hospital-site, and vice versa for the second group. All patients completed the Health Assessment Questionnaires (HAQ), the Visual Analogue Scales (VAS) for fatigue, pain and global health and the annual visit questions. Furthermore, AS patients completed the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the BAS Function Index (BASFI). Pearson9s Chi-square test, independent samples t-test and Mann-Whitney U test were calculated. Smallest detectable differences (SDDs), 95% confidence intervals (CIs) and intra-class correlation coefficients (ICCs) were calculated. Clinicaltrials.gov identifier: NCT02818478. <h3>Results</h3> A total of 952 patients received invitation, 45% accepted, 127 patients were contacted by phone, and 56 (44%) gave consent to participate. 22 patients with RA and 20 patients with AS completed the trial. All differences between scores from home vs hospital were smaller than SDD, and all were non-significant (p&lt;0.05), except for BASFI and BASDAI item 5. ICC ranged from 0.947–0.990 (p&lt;0.00001). Annual visit questions showed 96% concordance between the two methods. 50% of the patients preferred from home data entry over hospital and 10% vice versa. <h3>Conclusions</h3> Recruitment of patients for a randomized trial via touch screens was feasible. PROs collected from patients9 own devices at home generated results comparable to results obtained from the existing touch-screen solution and were preferred by the patients. <h3>References</h3> Schefte et al. (2010). <h3>Disclosure of Interest</h3> A. E. Secher: None declared, B. Glintborg Grant/research support from: AbbVie, H. Gudbergsen Speakers bureau: MSD and Pfizer, N. Krogh: None declared, D. Jensen: None declared, I. Sørensen: None declared, R. Christensen: None declared, M. Skougaard: None declared, M. Hetland Grant/research support from: AbbVie, BMS, MSD, Pfizer, UCB, Biogen, Orion
Mdm2 binds to and inhibits Nbs1 in a p53-independent manner
Authors: Alyssa C. Bouska, Christine M. Eischen
Journal: Cancer Research (2006)

4226  Mdm2 is best known for its direct regulation of the tumor suppressor p53, however, Mdm2 also has unresolved, p53-independent functions. Biochemical methods were used to identify novel p53-independent Mdm2-binding proteins. We identified an interaction of Mdm2 with Nbs1, Mre11, and Rad50, members of a DNA double-strand break repair complex. Mdm2 binds to the complex through a direct and specific association with Nbs1. Immunoprecipitation/western blotting, using Mdm2 deletion mutant constructs, localized the Nbs1 binding site in Mdm2 to its central domain. Similar experiments indicated that the central domain of Nbs1 was sufficient for Mdm2:Nbs1 association. Comet Assays (single-cell gel electrophoresis) performed under neutral conditions were used to analyze the DNA double-strand break response of Mdm2 overexpressing cells. Notably, Mdm2 overexpression inhibited DNA double-strand break repair. This delay was independent of p53 and ARF. Overexpressing the p53 binding domain of Mdm2 did not affect DNA repair. Additionally, Mdm2’s ubiquitin ligase domain and ubiquitin ligase activity were not required for inhibition of DNA repair. The delay in DNA repair was dependent on the Nbs1 binding domain in Mdm2. Mdm2 did not inhibit DNA repair in cells with mutant Nbs1. However, the inhibition of DNA repair by Mdm2 was restored in cells containing mutant Nbs1 upon reconstitution with wild type Nbs1, suggesting that wild type Nbs1 is necessary for Mdm2 to inhibit DNA repair. Therefore, Nbs1 is a novel, p53-independent, Mdm2 binding protein that links Mdm2 to the Nbs1/Mre11/Rad50-regulated DNA repair response.
AB1228-HPR In absence of specific advice, what do they eat and avoid? does it matter? diet evaluation of indian (ASIAN) patients of RA in a community rheumatology clinic
Authors: T Kianifard, M Saluja, A Chopra
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Diet in RA is generally considered to be inadequate/inappropriate. Rheumatologists often neglect this important patient concern. ACR/EULAR guidelines do not provide adequate advice. Ayurveda (ancient India medicine system) with highly restricted diet is popular with Indian patients. <h3>Objectives</h3> To evaluate diet adequacy in patients of RA in our setting <h3>Methods</h3> 139 consenting patients (ACR 1987 classified)on long term supervised care and 165 unmatched healthy subjects (mean age 37.7 years) were interviewed in no particular order as per protocol; cross sectional design. A 10 day diet recall period and a-priori validated questionnaires was used. National (India) recommended daily allowance (RDA) and diet analysis (web based and food composition tables) methods were used.Standard CRF captured clinical data [mean pain VAS 4.6 cms,mean HAQ score (Indian version) 6.5]. Standard statistical analysis (SPSS) was done; significant p&lt;0.05. <h3>Results</h3> Table 1 (women) and 2 (men) show average daily energy expenditure and consumption of selected food items, RDA and p values (on comparison: P (1) for patient versus control, P (2) for patient versus RDA: p by Mann Whitney). Compared to RDA, patient consumption was significantly higher for most of the items except K; includes calcium, phosphorus, zinc, iron, folic acid, vitamin B group (data not shown in Tables). When compared to healthy subjects, consumption was significantly lower for female patients but not different for men (except for K). Reduction in diet K in RA group was more pronounced for women. All patients tested normokalemic (mean serum K+ 4.37 mEq/l). No meaningful correlation between diet components and disease measures (data not shown).Food avoidance patterns identified a-priori did not seem to impact disease measures (data not shown). 44% RA and 77% controls consumed vegetarian diet (excluding eggs). Patient dependence for diet recall and measure was the important limiation. <h3>Conclusions</h3> The diet of RA patients seemed adequate except for an intriguingly low K. We speculate that patients eat lesser vegetables and fruits that source K. K sub serves several physiological functions that may be deranged in RA and contribute to disease progression. This would need further investigation. <h3>Acknowledgements</h3> In contrary to our expectations and reassuringly, the diet of RA patients seemed adequate except for an intriguingly low potassium which should be investigated. We speculate that patients eat lesser vegetables and fruits that source potassium. <h3>Disclosure of Interest</h3> None declared
FRI0657 Comparative study of parotid ultrasonography and parotid gland ect in predicting the pathological biopsy of the salivary gland in patients with primary sjÖgren's syndrome
Authors: C Xiaomei, L Cong, W Lijun, L Cainan, S Yamei
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Objectives</h3> To investigate the value of Parotid Ultrasonography and parotid gland radionuclide imaging in predicting salivary gland biopsy of primary Sjögren9s syndrome (pSS). <h3>Methods</h3> Sixty - five patients with primary Sjogren 9s syndrome and 38 patients with non - Sjogren9 s syndrome were enrolled in the Department of Rheumatology and Immunology, Xinjiang Uygur Autonomous Region People 9s Hospital from October, 2015 to June, 2016. All patients were accpted the check of Parotid Ultrasonography, Parotid Gland ECT and labial gland biopsy. The data were analyzed statistically. <h3>Results</h3> The sensitivity and specificity of Parotid Ultrasonography in pSS were 65% and 76%, respectively. The area under the ROC curve was 0.936±0.024 for the diagnosis of pSS. The positive predictive rate of parotid gland ultrasonography was 84.0% and the negative predictive rate was 94.4%. Parotid scintigraphy in pSS in the sensitivity of 80.0%, specificity of 69.1%. The positive predictive rate of parotid gland radionuclide imaging for labial gland biopsy was 78.9% and the negative predictive rate was 87.5%. The diagnostic value of Parotid Ultrasonography in pSS group is superior to that of parotid gland radionuclide imaging, which can effectively reduce the complication of invasive operation. <h3>Conclusions</h3> The diagnosis of pSS by parotid gland ultrasonography is superior to that of parotid gland radionuclide examination. For patients with atypical clinical manifestations who are negative for anti-SSA and/or anti-SSB antibodies, there is no need for a labial biopsy of the labial glands to reduce the number of complications associated with unwanted invasive procedures. <h3>Disclosure of Interest</h3> None declared
AB0533 Juvenile and juvenile-onset systemic lupus erythematosus patients: clinical characteristics, disease activity and damage
Authors: TA Gheita, RE Gheith, HS El-Fishawy, DMR Bahgat, AM El-Din Nour
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> The diagnosis of systemic lupus erythematosus (SLE) in children is challenging as the heterogeneous manifestations and disease impact on the child9s growth highlighted the importance of timely diagnosis and management. <h3>Objectives</h3> The aim of the present study was to assess and compare the clinical characteristics, disease activity and damage between juvenile (JSLE) and juvenile-onset (JO-SLE) Egyptian patients. <h3>Methods</h3> Seventy-eight SLE patients (26 JSLE and 52 JO-SLE) were included in this study. Disease activity was assessed using the SLE Disease Activity Index (SLEDAI) and organ damage using the Systemic Lupus International Collaborating Clinics (SLICC) index. <h3>Results</h3> The mean age of the JSLE children was 13.25±2.09 years and 23.17±4.26 years for JO-SLE cases. JO-SLE cases were older at disease onset with a higher female-to-male ratio. There were no noticeable gender differences. There was a significantly higher frequency of serositis, nephritis and hematological involvement in the JO-SLE (57.7%, 76.9% and 73.1%) compared to the JSLE cases (15.4%; 30.8% and 30.8%) (p&lt;0.001 for all). The erythrocyte sedimentation rate, creatinine and proteinuria were significantly increased in JO-SLE while alkaline phosphatase was higher in JSLE cases. In JO-SLE cases, SLEDAI significantly increased (5.96±6.18 <i>vs</i> 3.12±1.97; p=0.003) and the SLICC tended to increase compared to the JSLE children. More JO-SLE cases received hydroxychloroquine and azathioprine. <h3>Conclusions</h3> The existence of differences in clinical phenotype has been confirmed, between JSLE and JO-SLE especially as regards serositis, nephritis and heamatological affection. The disease damage was comparable which denotes that the maximum organ involvement occurs in childhood with an almost stationary course. Rheumatologists caring for children with SLE must be aware of the greater risk of major haematological and renal involvement as well as important long-term morbidity. <h3>Disclosure of Interest</h3> None declared
Arsenic in Dermatology—From Dermatologic Therapy to Carcinogen
Authors: Connie R. Shi, Vinod E. Nambudiri
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand
Authors: Sang W. Kang, Sang C. Lee, So H. Park, Juyang Kim, Hyeon H. Kim, Hyeon-Woo Lee, Su K. Seo, Byoung S. Kwon, Hong R. Cho, Byungsuk Kwon
Journal: Cancer Research (2017)

CD137 (4-1BB) is a T-cell costimulatory molecule, and agonstic CD137 antibodies are currently being evaluated in the clinic as cancer immunotherapy. Recently, it was found that CD137-/- mice or mice injected with agonistic anti-CD137 antibodies exhibit heightened antitumor responses, contrary to expectations based on other knowledge of CD137 function. Here, we report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results. Specifically, CD137L suppressed intratumoral differentiation of IL12-producing CD103+ DC and type 1 tumor-associated macrophages (TAM). Differentiation of these cell types is important because they are required to generate IFNγ-producing CD8+ cytotoxic T lymphocytes (Tc1). Notably, CD137L blockade increased levels of IL12 and IFNγ, which promoted intratumoral differentiation of IFNγ-producing Tc1, IL12-producing CD103+ DC, and type 1 TAM within tumors. Our results offer an explanation for the paradoxical effects of CD137 blockade, based on differential immunomodulatory effects of CD137 signaling and reverse signaling in T cells and DC, respectively. Further, they show how CD137L blockade can seed a forward-feedback loop for activation of CD103+ DC/type 1 TAM and Tc1 that can create a self-perpetuating cycle of highly effective immunosurveillance. Cancer Res; 77(21); 5989-6000. ©2017 AACR.