tbuckley/cabot-search huggingface dataset:
Cigarette Smoking and Incident Heart Failure
Authors: Daisuke Kamimura, Loretta R. Cain, Robert J. Mentz, Wendy B. White, Michael J. Blaha, Andrew P. DeFilippis, Ervin R. Fox, Carlos J. Rodriguez, Rachel J. Keith, Emelia J. Benjamin, Javed Butler, Aruni Bhatnagar, Rose M. Robertson, Michael D. Winniford, Adolfo Correa, Michael E. Hall
Journal: Circulation (2018)

Cigarette smoking has been linked with several factors associated with cardiac dysfunction. We hypothesized that cigarette smoking is associated with left ventricular (LV) structure and function, and incident heart failure (HF) hospitalization.
Demethylation increases the expression of type 3 inositol 1, 4, 5-trisphosphate receptor in hepatocytes
Authors: R.M. Florentino, A. França, A.C.M.L. Filho, M.C. Fonseca, A.G. Oliveira, C.X. Lima, P.V.T. Vidigal, M. de Fátima Leite
Journal: Journal of Hepatology (2018)
Abstract 14119: Fibulin-1 Plays a Role in Smooth Muscle Cell Migration and Intimal Thickening in the Ductus Arteriosus
Authors: Satoko Ito, Utako Yokoyama, Chiharu Yanai, Munetaka Masuda, Toshihide Asou, Yoshihiro Ishikawa
Journal: Circulation (2016)

Introduction: Closure of the ductus arteriosus (DA) consists of two processes, i.e., vasoconstriction and intimal thickening (IT). Premature infants with patent DA (PDA), in which IT is not suffici...
Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System)
Authors: Valeria Panebianco, Yoshifumi Narumi, Ersan Altun, Bernard H. Bochner, Jason A. Efstathiou, Shaista Hafeez, Robert Huddart, Steve Kennish, Seth Lerner, Rodolfo Montironi, Valdair F. Muglia, Georg Salomon, Stephen Thomas, Hebert Alberto Vargas, J. Alfred Witjes, Mitsuru Takeuchi, Jelle Barentsz, James W.F. Catto
Journal: European Urology (2018)
The intensive care unit course and outcome in acute-on-chronic liver failure are comparable to other populations
Authors: Philippe Meersseman, Lies Langouche, Johannie du Plessis, Hannelie Korf, Michaël Mekeirele, Wim Laleman, Frederik Nevens, Alexander Wilmer, Greet Van den Berghe, Schalk W. van der Merwe
Journal: Journal of Hepatology (2018)
Genetic Dissection of Neural Circuits: A Decade of Progress
Authors: Liqun Luo, Edward M. Callaway, Karel Svoboda
Journal: Neuron (2018)

Tremendous progress has been made since Neuron published our Primer on genetic dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical, neurophysiological, and perturbation studies have been carried out in a multitude of invertebrate and vertebrate organisms, linking neurons and circuits to behavioral functions. New methods allow systematic classification of cell types and provide genetic access to diverse neuronal types for studies of connectivity and neural coding during behavior. Here we evaluate key advances over the past decade and discuss future directions.
TCTAP C-126 Thrombus Management During Intervention for an Occluded Right Coronary Artery
Authors: Chang-Jen Chen, Chun-Yuan Chu, Wen-Hsien Lee, Po-Chao Hsu, Cheng-An Chiu, Ho-Ming Su, Tsung-Hsien Lin, Chee-Siong Lee, Heueh-Wei Yen, Wen-Chol Voon, Wen-Ter Lai, Sheng-Hsiung Sheu
Journal: Journal of the American College of Cardiology (2018)
Measuring the quality of breast cancer care: National variation in the use of radiation among women under age 70
Authors: S. B. Edge, A. Stewart, L. Patel-Parekh, G. Gay, B. Palis, C. Ko
Journal: Journal of Clinical Oncology (2007)

599 The National Quality Forum (NQF) recently adopted accountability cancer quality measures. Careful specification of target populations makes it so that omission of recommended therapy should be uncommon. One measure is use of radiation (RT) with breast conserving therapy (BCT) for women under age 70. This study examines nationwide use of RT in 2003–04 to determine the extent of variation and the need for improvement within these tight specifications. Methods: Data from 1,303 hospitals reporting to the National Cancer Data Base (NCDB) on women under age 70 treated with BCT in 2003–04 for invasive breast cancer were examined for factors associated with the use of RT in a multivariate model. The attributable provider unit was the reporting hospital. Results: Overall among 90,611 women under age 70, RT was reported with BCT in 74.5%. RT began within 6 months diagnosis in 54% and 1 yr in 74.2%. On multivariable analysis ( Table 1 ), RT was significantly less likely among African American and Hispanic vs. Caucasian women, those with less vs. more education, with no insurance or Medicaid vs. managed care, those with Charlson comorbidity &gt; 0, women treated outside the Great Lakes/Midwest census regions, and treated at hospitals in the lower vs. higher quartiles of case volume. RT was administered to 73% of women in non-urban hospitals, and to 82% of women in urban hospitals. RT was administered to 75% and 77% of women age 50 - 59 and 60 - 69, respectively, compared to 68% and 72% of women age &lt; 40 and 40 - 49. Conclusions: Despite limiting measurement to populations that should clearly receive RT with BCT, there are significant variations associated with patient and institutional characteristics. Reporting cancer care quality data is important, and the use of RT with BCT is a key quality measure for improvement and provider accountability. [Table: see text] No significant financial relationships to disclose.
Functional immune characterization of HIV-associated non-small-cell lung cancer
Authors: D.J. Pinato, A. Kythreotou, F.A. Mauri, E. Suardi, E. Allara, R.J. Shiner, A.U. Akarca, P. Trivedi, N. Gupta, A. Dalla Pria, T. Marafioti, P. Oliveri, T. Newsom-Davis, M. Bower
Journal: Annals of Oncology (2018)
Orthodontic tooth separation activates the hypothalamic area in the human brain
Authors: Yoshiko Ariji, Hisataka Kondo, Ken Miyazawa, Masako Tabuchi, Syuji Koyama, Yoshitaka Kise, Akifumi Togari, Shigemi Gotoh, Eiichiro Ariji
Journal: International Journal of Oral Science (2018)

An animal experiment clarified that insertion of an orthodontic apparatus activated the trigeminal neurons of the medulla oblongata. Orthodontic tooth movement is known to be associated with the sympathetic nervous system and controlled by the nucleus of the hypothalamus. However, the transmission of both has not been demonstrated in humans. The purpose of this study were to examine the activated cerebral areas using brain functional magnetic resonance imaging (MRI), when orthodontic tooth separators were inserted, and to confirm the possibility of the transmission route from the medulla oblongata to the hypothalamus.Two types of alternative orthodontic tooth separators (brass contact gauge and floss) were inserted into the right upper premolars of 10 healthy volunteers. Brain functional T2*-weighted images and anatomical T1-weighted images were taken.The blood oxygenation level dependent (BOLD) signals following insertion of a brass contact gauge and floss significantly increased in the somatosensory association cortex and hypothalamic area.Our findings suggest the possibility of a transmission route from the medulla oblongata to the hypothalamus.
Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus–induced type 2 responses and immunopathology
Authors: Melissa H. Bloodworth, Mark Rusznak, Connor C. Pfister, Jian Zhang, Lisa Bastarache, Sandra Alvarez Calvillo, James D. Chappell, Kelli L. Boyd, Shinji Toki, Dawn C. Newcomb, Matthew T. Stier, Weisong Zhou, Kasia Goleniewska, Martin L. Moore, Tina V. Hartert, Kevin D. Niswender, R. Stokes Peebles
Journal: Journal of Allergy and Clinical Immunology (2018)
Key mutational patterns in HBsAg C-terminus profoundly affect HBsAg levels in HBeAg-negative chronic HBV genotype D infection
Authors: R. Salpini, A. Battisti, L. Carioti, D.D. Carlo, O. Anastasiou, U.S. Gill, L. Colagrossi, A. Bertoli, M. Aragri, L. Fabeni, V. Fini, L. Piermatteo, A. Iuvara, V. Malagnino, C. Cerva, M. Lichtner, C.M. Mastroianni, G.M.D. Sanctis, P. Maurizio, M. Marignani, C. Pasquazzi, N. Iapadre, T. Mari, G. Parruti, J. Vecchiet, L. Sarmati, M. Andreoni, M. Angelico, S. Grelli, P. Kennedy, J. Verheyen, F.C. Silberstein, C.F. Perno, V. Svicher
Journal: Journal of Hepatology (2018)
Anti–Epidermal Growth Factor Vaccine Antibodies Enhance the Efficacy of Tyrosine Kinase Inhibitors and Delay the Emergence of Resistance in EGFR Mutant Lung Cancer Cells
Authors: Jordi Codony-Servat, Silvia García-Roman, Miguel Ángel Molina-Vila, Jordi Bertran-Alamillo, Ana Giménez-Capitán, Santiago Viteri, Andrés F Cardona, Erik D’Hondt, Niki Karachaliou, Rafael Rosell
Journal: Journal of Thoracic Oncology (2018)
Evolving Payer Coverage Policies on Genomic Sequencing Tests
Authors: Kathryn A. Phillips
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes
Authors: Sandhya R. Panch, Michael E. Bozik, Thomas Brown, Michelle Makiya, Calman Prussin, Donald G. Archibald, Gregory T. Hebrank, Mary Sullivan, Xiaoping Sun, Lauren Wetzler, JeanAnne Ware, Michael P. Fay, Cynthia E. Dunbar, Steven I. Dworetzky, Paneez Khoury, Irina Maric, Amy D. Klion
Journal: Blood (2018)
Abstract 16161: Bone Marrow Characteristics are Associated With Changes in Infarct Size Following STEMI: A Biorepository Evaluation From the CCTRN TIME Trial
Authors: Robert C Schutt, Barry H Trachtenberg, John P Cooke, Jay H Traverse, Timothy D Henry, Carl J Pepine, James T Willerson, Emerson C Perin, Stephen G Ellis, David X Zhao, Aruni Bhatnagar, Brian H Johnstone, Dejian Lai, Micheline Resende, Ray F Ebert, Joseph C Wu, Shelly L Sayre, Robert D Simari, Lem Moye', Christopher R Cogle, Doris A Taylor
Journal: Circulation (2014)

OBJECTIVE: Despite significant interest in bone marrow cell mononuclear cell (BMC) therapy for ischemic heart disease, current techniques have shown only modest benefit. However, select patients show improvements after autologous BMC therapy for unknown reasons. The purpose of this study was to identify BMC characteristics associated with infarct size reduction following STEMI. METHODS: This study evaluated prospectively the cohort of patients enrolled in the CCTRN TIME trial who agreed to their BMCs being stored and used for further analyses at the CCTRN Biorepository. Analyses were pre-specified and the core laboratories were blinded to clinical data and treatment assignments. The changes in infarct size between baseline (three days after PCI) and 6 months was measured by cMRI. BMC product underwent phenotype analysis using FACS identifying cells expressing CD45, CD34, CD31, CD133, CXCR4, CD3, CD11, CD14, and CD19 and functional analysis with the CFU-Hill, ECFC and CFU-F assays. RESULTS: Quantification of BMC characteristics and infarct size was available in 101 patients. The patients’ mean age was 56.5 years, with a mean screening ejection fraction of 37% and mean baseline cMRI ejection fraction of 45%. At 6 months, 75 (74.3%) patients had reductions in infarct size (mean -21.0% ± 17.6%). Multiple regression analysis revealed that, regardless of treatment allocation, an increased percentage of BMC that expressed CD31 (p=0.046) was associated with greater reductions in infarct size. Greater reductions in infarct size also were associated with more rapid growth rates for BMC functional assays (CFU-Hill, ECFC) (p=0.033, p=0.032, respectively). CONCLUSIONS: This study demonstrates a correlation between characteristics of BMCs in the acute STEMI phase and subsequent changes in infarct size. These data suggest that resident BMCs (specifically, endothelial precursors) play an important role in regenerating infarcted myocardium irrespective of treatment with autologous BMC transplantation.
Validation of Non-Invasive MRI-based Assessment of Central Blood Pressure in a Population of Repaired Coarctation Patients
Authors: Arna van Engelen, Jorge Mariscal Harana, Torben Schneider, Mateusz Florkow, Peter Harcourt Charlton, Bram Ruijsink, Hubrecht de Bliek, Israel Valverde Perez, Marietta Charakida, Kuberan E Pushparajah, Rene Michael Botnar, Jordi Alastruey-Arimon
Journal: Circulation (2017)
Good to Begin Well, Better to End Well
Authors: June K. Robinson
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
A New Framework for Patient Engagement in Cancer Clinical Trials Cooperative Group Studies
Authors: Patricia A Deverka, Rick Bangs, Karma Kreizenbeck, Deborah M Delaney, Dawn L Hershman, Charles D Blanke, Scott D Ramsey
Journal: JNCI Journal of the National Cancer Institute (2018)

For the past two decades, the National Cancer Institute (NCI) has supported the involvement of patient advocates in both internal advisory activities and funded research projects to provide a patient perspective. Implementation of the inclusion of patient advocates has varied considerably, with inconsistent involvement of patient advocates in key phases of research such as concept development. Despite this, there is agreement that patient advocates have improved the patient focus of many cancer research studies. This commentary describes our experience designing and pilot testing a new framework for patient engagement at SWOG, one of the largest cancer clinical trial network groups in the United States and one of the four adult groups in the NCI's National Clinical Trials Network (NCTN). Our goal is to provide a roadmap for other clinical trial groups that are interested in bringing the patient voice more directly into clinical trial conception and development. We developed a structured process to engage patient advocates more effectively in the development of cancer clinical trials and piloted the process in four SWOG research committees, including implementation of a new Patient Advocate Executive Review Form that systematically captures patient advocates' input at the concept stage. Based on the positive feedback to our approach, we are now developing training and evaluation metrics to support meaningful and consistent patient engagement across the SWOG clinical trial life cycle. Ultimately, the benefits of more patient-centered cancer trials will be measured in the usefulness, relevance, and speed of study results to patients, caregivers, and clinicians.
Durable response in the markers of cholestasis through 36 months of open-label extension study of obeticholic acid in primary biliary cholangitis
Authors: M. Trauner, F. Nevens, M. Shiffman, J.P.H. Drenth, C. Bowlus, V.M.V. Blasco, P. Andreone, R. Pencek, E.S. Malecha, L. Macconell, D. Shapiro
Journal: Journal of Hepatology (2018)
miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer
Authors: Jina Ko, Neha Bhagwat, Taylor Black, Stephanie S. Yee, Young-Ji Na, Stephen Fisher, Junhyong Kim, Erica L. Carpenter, Ben Z. Stanger, David Issadore
Journal: Cancer Research (2018)

Abstract Improved diagnostics for pancreatic ductal adenocarcinoma (PDAC) to detect the disease at earlier, curative stages and to guide treatments is crucial to progress against this disease. The development of a liquid biopsy for PDAC has proven challenging due to the sparsity and variable phenotypic expression of circulating biomarkers. Here we report methods we developed for isolating specific subsets of extracellular vesicles (EV) from plasma using a novel magnetic nanopore capture technique. In addition, we present a workflow for identifying EV miRNA biomarkers using RNA sequencing and machine-learning algorithms, which we used in combination to classify distinct cancer states. Applying this approach to a mouse model of PDAC, we identified a biomarker panel of 11 EV miRNAs that could distinguish mice with PDAC from either healthy mice or those with precancerous lesions in a training set of n = 27 mice and a user-blinded validation set of n = 57 mice (88% accuracy in a three-way classification). These results provide strong proof-of-concept support for the feasibility of using EV miRNA profiling and machine learning for liquid biopsy. Significance: These findings present a panel of extracellular vesicle miRNA blood-based biomarkers that can detect pancreatic cancer at a precancerous stage in a transgenic mouse model. Cancer Res; 78(13); 3688–97. ©2018 AACR.
Inconsistent with the data: Support for the CLASH model depends on the wrong kind of latitude
Authors: Darren Burke, Danielle Sulikowski, Ian Stephen, Robert Brooks
Journal: Behavioral and Brain Sciences (2017)

We argue that the CLASH model makes a number of questionable assumptions about the harshness and unpredictability of low-latitude environments, calling into question the life history strategy approach used, and that it is inconsistent with more nuanced global patterns of violence. We suggest an alternative account for less violence at high latitudes, based on a greater need for cooperation.
A Multicenter, Prospective, Randomized, Controlled Trial Of Endobronchial Valve Treatment Vs Standard Of Care In Heterogeneous Emphysema (transform)
Authors: S. V. Kemp, D. J Slebos, A. Kirk, M. Kornaszewska, K. Carron, L. Ek, H. Mal, C. Pison, N. J. Downer, Gustav Broman, K. Darwiche, J. Rao, R. H Hubner, V. Trosini-Desert, R. Eberhardt, F. J. F. Herth, E. Derom, C. H. Marquette
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

A Multicenter, Prospective, Randomized, Controlled Trial Of Endobronchial Valve Treatment Vs Standard Of Care In Heterogeneous Emphysema (transform)
Dual therapy for Aβ amyloidosis in AD: A successful one-two combo
Authors: Tirth K. Patel, David M. Holtzman
Journal: The Journal of Experimental Medicine (2018)

In this issue, Chiang et al. (https://doi.org/10.1084/jem.20171484) make a notable contribution to Alzheimer disease (AD) therapeutics in a thorough and rigorous study demonstrating superior efficacy of dual therapy against Aβ in a mouse model of amyloid β deposition.
Is obtention of partial response (PR) in front line chemotherapy critical to improve outcome of metastatic soft tissue sarcoma (MSTS) patients (pts)
Authors: A. le Cesne, I. Judson, D. Crowther, R. Somers, T. Tursz, J. Keizer, Q.G.C.M. van Hoesel, J.Y. Blay, H. Frisch, M. van Glabbeke, A. van Oosterom, J. Verweij
Journal: Annals of Oncology (1998)
Tofacitinib in steroid-dependent relapsing polychondritis
Authors: Alexey D Meshkov, Pavel I Novikov, Evgeny V Zhilyaev, Ilia David J Ilevsky, Sergey V Moiseev
Journal: Annals of the Rheumatic Diseases (2018)

Relapsing polychondritis (RP) is a rare progressive inflammatory condition involving cartilaginous structures, predominantly those of the ears, nose and laryngotracheobronchial tree. The McAdam’s diagnostic criteria require meeting three out of six of the following: recurrent chondritis of both auricles, nonerosive inflammatory polyarthritis, chondritis of nasal cartilages, ocular inflammation (conjunctivitis, keratitis, scleritis and/or uveitis), chondritis of respiratory tract, cochlear and/or vestibular damage (neurosensory hearing loss, tinnitus or vertigo).1 Systemic corticosteroids remain the mainstay of treatment for RP. Immunosuppressive agents (eg, methotrexate, azathioprine, dapsone, cyclophosphamide, etc) have been frequently used for the treatment of more severe and steroid-resistant manifestations of RP. The administration of biologics in patients with RP has been also described.2 3 

In the recently published French multicentre retrospective cohort study, Moulis et al reported 41 patients with RP treated with 105 biological agents, including tumour necrosis factor (TNF) inhibitors, tocilizumab, anakinra, rituximab and abatacept.4 The reasons for initiating biological therapy were corticosteroid dependence, corticosteroid resistance or intolerance to methotrexate. …
PD-L1 Expression Heterogeneity in Non–Small Cell Lung Cancer: Defining Criteria for Harmonization between Biopsy Specimens and Whole Sections
Authors: Enrico Munari, Giuseppe Zamboni, Gianluigi Lunardi, Luigi Marchionni, Marcella Marconi, Marco Sommaggio, Matteo Brunelli, Guido Martignoni, George J. Netto, Mohammad O. Hoque, Francesca Moretta, Maria Cristina Mingari, Maria Cristina Pegoraro, Alessandro Inno, Simona Paiano, Alberto Terzi, Alberto Cavazza, Giulio Rossi, Francesca Romana Mariotti, Paola Vacca, Lorenzo Moretta, Giuseppe Bogina
Journal: Journal of Thoracic Oncology (2018)
Neutral Theory and the Somatic Evolution of Cancer
Authors: Vincent L Cannataro, Jeffrey P Townsend
Journal: Molecular Biology and Evolution (2018)

Kimura's neutral theory argued that positive selection was not responsible for an appreciable fraction of molecular substitutions. Correspondingly, quantitative analysis reveals that the vast majority of substitutions in cancer genomes are not detectably under selection. Insights from the somatic evolution of cancer reveal that beneficial substitutions in cancer constitute a small but important fraction of the molecular variants. The molecular evolution of cancer community will benefit by incorporating the neutral theory of molecular evolution into their understanding and analysis of cancer evolution-and accepting the use of tractable, predictive models, even when there is some evidence that they are not perfect.