Long-Term Effectiveness of Sigmoidoscopy Screening in Women and Men
Authors: Øyvind Holme, Magnus Løberg, Mette Kalager, Michael Bretthauer, Geir Hoff
Journal: Annals of Internal Medicine (2018)

Letters6 November 2018Long-Term Effectiveness of Sigmoidoscopy Screening in Women and MenØyvind Holme, MD, PhD, Magnus Løberg, MD, PhD, Mette Kalager, MD, PhD, Michael Bretthauer, MD, PhD, and Geir Hoff, MD, PhDØyvind Holme, MD, PhDUniversity of Oslo Institute of Health and Society and Oslo University Hospital, Oslo, Norway (Ø.H., M.L., M.K., M.B.), Magnus Løberg, MD, PhDUniversity of Oslo Institute of Health and Society and Oslo University Hospital, Oslo, Norway (Ø.H., M.L., M.K., M.B.), Mette Kalager, MD, PhDUniversity of Oslo Institute of Health and Society and Oslo University Hospital, Oslo, Norway (Ø.H., M.L., M.K., M.B.), Michael Bretthauer, MD, PhDUniversity of Oslo Institute of Health and Society and Oslo University Hospital, Oslo, Norway (Ø.H., M.L., M.K., M.B.), and Geir Hoff, MD, PhDTelemark Hospital, Skien, Norway (G.H.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0512 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Drs. Shaukat and Church that sex- and age-based differences in CRC screening are important issues that deserve more attention. In addition to the NORCCAP (Norwegian Colorectal Cancer Prevention) trial and PLCO Cancer Screening Trial, flexible sigmoidoscopy was significantly less effective in women in the UK Flexible Sigmoidoscopy Screening trial. In this study, the HR for CRC incidence was 0.81 (95% CI, 0.73 to 0.89) in women and 0.70 (CI, 0.65 to 0.77) in men (P for interaction = 0.047) (1). As Drs. Shaukat and Church also note, long-term follow-up of the Minnesota fecal occult blood testing ...References1. Atkin W, Wooldrage K, Parkin DM, Kralj-Hans I, MacRae E, Shah U, et al. Long term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK Flexible Sigmoidoscopy Screening randomised controlled trial. Lancet. 2017;389:1299-1311. [PMID: 28236467] doi:10.1016/S0140-6736(17)30396-3 CrossrefMedlineGoogle Scholar2. Holme Ø, Schoen RE, Senore C, Segnan N, Hoff G, Løberg M, et al. Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials. BMJ. 2017;356:i6673. [PMID: 28087510] doi:10.1136/bmj.i6673 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Oslo Institute of Health and Society and Oslo University Hospital, Oslo, Norway (Ø.H., M.L., M.K., M.B.)Telemark Hospital, Skien, Norway (G.H.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-1441. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men Øyvind Holme , Magnus Løberg , Mette Kalager , Michael Bretthauer , Miguel A. Hernán , Eline Aas , Tor J. Eide , Eva Skovlund , Jon Lekven , Jörn Schneede , Kjell Magne Tveit , Morten Vatn , Giske Ursin , Geir Hoff , and Long-Term Effectiveness of Sigmoidoscopy Screening in Women and Men Aasma Shaukat and Timothy R. Church Metrics Cited byUKCTOCS update: applying insights of delayed effects in cancer screening trials to the long-term follow-up mortality analysisField carcinogenesis for risk stratification of colorectal cancer 6 November 2018Volume 169, Issue 9Page: 663-664KeywordsCancer preventionCancer screeningColonColorectal cancerDisclosureFlexible sigmoidoscopyHematologic testsRectumRelative risk ePublished: 6 November 2018 Issue Published: 6 November 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...