tbuckley/cabot-search huggingface dataset:
Intravenous Alteplase for Mild Nondisabling Acute Ischemic Stroke
Authors: William J. Powers
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Repercusión del sangrado activo detectado mediante cápsula endoscópica
Authors: B Antolín Melero, J Santos Fernández, M Dura Gil, L Fernández Salazar, B Velayos, C Alonso Martin, B Burgueño Gómez, N Mora Cuadrado, JM González Hernández
Journal: Endoscopy (2017)

La cápsula endoscópica (CE) es una técnica mínimamente invasiva que permite la valoración total del intestino delgado con elevada sensibilidad, siendo una exploración de primera línea para el estudio de HDOO. Pretendemos estudiar los factores asociados y la evolución clínica de los pacientes a los que se les detecta sangrado activo mediante CE.
UPPER GASTROINTESTINAL BLEEDING ASSOCIATED WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
Authors: F Errabie, A Elmekkaoui, W Khannoussi, G Kharrasse, Z Ismaili
Journal: Endoscopy (2018)

The aim of our study is to evaluate the epidemiological, clinical, endoscopic and evolutionary characteristics of Upper gastrointestinal bleeding (UGIB) associated with Non-steroidal anti-inflammatory drugs (NSAIDs).
Abstract 69: Possible Involvement Of Proline-rich Tyrosine Kinase 2 (pyk2) In The Pathogenesis Of Kawasaki Disease
Authors: Chinatsu Suzuki, Akihiro Nakamura, Mitsuhiko Okigaki, Noriko Miura, Naohito Ohno, Tomoyo Yahata, Akiko Okamoto, Ayako Yoshioka, Yuki Kuchitsu, Kazuyuki Ikeda, Kenji Hamaoka
Journal: Circulation (2015)

Introduction: Although etiology of Kawasaki disease (KD) remains elusive, a line of recent experimental studies implies that some kinds of infectious stimuli are implicate in the vasculitis through uncontrolled innate immune systems such as pattern recognition receptor (PPR)-mediated inflammatory signaling. It has already known that Candida albicans water-soluble fraction (CAWS) inducing KD-like vasculitis in mice function through PRP. Furthermore, it is reported that proline-rich tyrosine kinase (Pyk2), which is molecule involved in the PRPs-dependent signaling pathways, plays an important role in activation of NF-κB. Therefore, we investigated a possible relevance of Pyk2 in the pathogenesis of KD. Methods: Pyk2-knock out (Pyk2-KO) and wild-type C57BL/6 mice (WT) were administered CAWS to induce KD-like vasculitis. Extension of the experimental vasculitis was immunohistochemically determined with anti-MPO antibody. CAWS-stimulated NF-κB activation was evaluated by quantifying nuclear translocation of NF-κB p65 subunit in peritoneal macrophages isolated from PYK2-KO and wild-type mice in vitro. Cytokines and chemokines across each mice were compared by cytokine array. Results: Pyk2-KO mice didn’t show any apparent defective phenotype. While marked inflammation was observed in the aortic root of CAWS-treated WT mice, such vasculitis was barely detected in CAWS-treated Pyk2-KO mice. CAWS-induced NF-κB activation was also less observed in macrophages from Pyk2-KO mice. There were differences in some cytokines and chemokines production between mice. Conclusion: We speculate that Pyk2 is involved in the pathogenesis of KD. Pyk2 might be a potential therapeutic target for KD.
Factores asociados con el éxito en intubación ileal en pacientes con anastomosis ileocólica
Authors: N García Morales, N Alonso Lázaro, D Álvarez De Sotomayor, M García Campos, C Satorres Paniagua, A Nevárez Heredia, M Ponce Romero, M Bustamante Balén, L Argüello Viúdez, V Pons Beltrán
Journal: Endoscopy (2017)

La exploración del íleon es fundamental en el seguimiento de algunos pacientes con anastomosis ileocólica, como ocurre en la valoración de la recurrencia en la Enfermedad de Crohn (EC). Se desconoce si existen factores asociados al éxito en la intubación ileal.
Abstract 14046: Cardiac Magnetic Resonance Imaging in Active and Borderline Biopsy-proven Myocarditis: Results From a Prospective Series
Authors: Alida L Caforio, Alessandro Schiavo, Martina Perazzolo Marra, Martina Testolina, Loira Leoni, Claudio Bilato, Renzo Marcolongo, Annalisa Angelini, Cristina Basso, Marco Panfili, Giambattista Isabella, Giuseppe Tarantini, Massimo Napodano, Gaetano Thiene, Gino Gerosa, Sabino Iliceto
Journal: Circulation (2013)

Cardiac magnetic resonance (CMR) with T2-weighted STIR (T2W) and T1-weighted late gadolinium enhancement (LGE) sequences is widely used in the non-invasive diagnosis of myocarditis, but its role in...
Salvage pembrolizumab added to kinase inhibitor therapy for the treatment of anaplastic thyroid carcinoma
Authors: Priyanka C. Iyer, Ramona Dadu, Maria Gule-Monroe, Naifa L. Busaidy, Renata Ferrarotto, Mouhammed Amir Habra, Mark Zafereo, Michelle D. Williams, G. Brandon Gunn, Horiana Grosu, Heath D. Skinner, Erich M. Sturgis, Neil Gross, Maria E. Cabanillas
Journal: Journal for ImmunoTherapy of Cancer (2018)

<h3>Background</h3> Anaplastic thyroid carcinoma (ATC) is a rare but deadly form of thyroid cancer. Kinase inhibitors kinase inhibitors have shown clinical efficacy in the management of ATC, however, eventually these tumors acquire resistance to KI and patients succumb to their disease. Salvage therapy in this setting is limited. As ATC tumors diffusely express the programmed cell death protein ligand (PD-L1), anti- programmed cell death protein (PD-1) drugs such as pembrolizumab offer therapeutic potential. We sought to explore the efficacy of adding pembrolizumab to kinase inhibitors&nbsp;at progression in ATC. <h3>Methods</h3> We retrospectively reviewed the charts of ATC patients initiated on pembrolizumab in combination with KI at the time of progression on kinase inhibitors at MD Anderson Cancer Center between August 2016 and August 2017. Efficacy was evaluated with best overall response (BOR) using RECISTv1.1 criteria. Progression free survival (PFS) from the start of pembrolizumab and overall survival (OS) from the start of kinase inhibitors, as well as from the time of addition of pembrolizumab were calculated. <h3>Results</h3> Twelve patients were treated with combination kinase inhibitors plus pembrolizumab at the time of progression on their KI therapy. Median age at initiation of pembrolizumab was 60&nbsp;years (range 47–84&nbsp;years). BOR was as follows: 5/12 (42%) had partial response, 4/12 (33%) had stable disease and 3/12 (25%) had progressive disease. Median OS from the start of kinase inhibitor was 10.43&nbsp;months (95% CI = 6.02, 14.83, range 5.4–40&nbsp;months). Median OS and PFS from the addition of pembrolizumab were 6.93&nbsp;months (95% CI = 1.7, 12.15, range 3–15.9&nbsp;months) and 2.96&nbsp;months (95% CI = 2.2, 3.7, range 0.57–13.14&nbsp;months), respectively. Fatigue, anemia and hypertension were the most common AEs encountered on these combinations. Therapy had to be discontinued in 2 patients due to drug induced rash and altered mental status likely from progression of disease. <h3>Conclusion</h3> In a subset of ATC patients, pembrolizumab may be an effective salvage therapy added to kinase inhibitors at the time of progression on these drugs. However, better treatment strategies aimed at incorporating immunotherapy in patients with ATC should be explored. Frontline combination of KI with immunotherapy should be studied in prospective clinical trials.
The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials
Authors: Maryam Akbari, Vahidreza Ostadmohammadi, Kamran B. Lankarani, Reza Tabrizi, Fariba Kolahdooz, Seyed Reza Khatibi, Zatollah Asemi
Journal: Metabolism (2018)
Sixty seconds on . . . exercise
Authors: Ingrid Torjesen
Journal: BMJ (2018)

Yes. 10 000 steps a day, religiously. I always get off the bus a stop early on the way to work, and I walk to the pub when I’m catching up with my mates to make sure I hit the target.

No. I don’t go very fast because I don’t want to get hot and sweaty. It wouldn’t be fair on my work colleagues or my …
Severe problems with interhospital transfer of critically ill children will continue
Authors: A. Sharples, O. Dearlove
Journal: BMJ (1996)

proportion of patients requiring high depend- ency and intensive care.To accommodate the additional emergency caseload we have returned about one third of elective cases, scheduled for high dependency care on the unit, direct to the ward.This has put additional strain on the ward staff.Cancellations of elective surgery requiring postoperative intensive care have unavoidably increased.Our experience highlights the underprovision of intensive care beds in the south east ofEngland.We welcome the recent announcement by the secre- tary of state for health of increased provision of intensive care services,' but in the neurosciences we think that it may be too little too late.
Risk of cardiovascular morbidity and mortality following TNF-blockade. Preliminary results of an ongoing Swedish monitoring-programme of biologics in RA
Authors: J Askling, C M Fored, L Brandt, E Baecklund, L Bertilsson, L Coster, P Geborek, L T Jacobsson, S Lindblad, J Lysholm, Solbritt Rantapää-Dahlqvist, T Saxne, N Feltelius, L Klareskog
Journal: Annals of the Rheumatic Diseases (2005)

Risk of cardiovascular morbidity and mortality following TNF-blockade. Preliminary results of an ongoing Swedish monitoring-programme of biologics in RA
Abstract 13592: M-Mode versus 2D Echocardiography-based Measurements of LV Dimensions: Different Reference Thresholds
Authors: Sherif F Nagueh, Katrina K Poppe, Julius M Gardin, Håvard Dalen, Gillian A Whalley
Journal: Circulation (2013)

LV dimensions and wall thickness by M-Mode echocardiography (echo) appear to be larger than 2D based measurements. This has implications for determining upper limits of normal for measurements acqu...
Análisis del resangrado en hemorragia digestiva alta: factores de riesgo
Authors: R Jiménez-Rosales, F Valverde-López, E Fernández-Fernández, JG Martínez-Cara, F Vadillo-Calles, P Abellán-Alfocea, EJ Ortega-Suazo, E Redondo-Cerezo
Journal: Endoscopy (2017)

La hemorragia digestiva alta (HDA) está asociada a mortalidad y morbilidad significativas. El resangrado aparece en el 10 – 20% de los pacientes y supone un incremento de la mortalidad; siendo la definición de factores predictivos de éste de vital importancia.
CLINICAL OUTCOMES OF EUS-GUIDED ETHANOL ABLATION IS BETTER THAN THOSE OF THE NATURAL COURSE OF PANCREATIC CYSTS
Authors: JK Ryu, KN Shim, YT Kim, YB Yoon
Journal: Endoscopy (2018)

Endoscopic ultrasonography-guided ethanol ablation therapy for pancreatic cystic tumors is a minimally invasive treatment but still is an experimental therapy. The aim of this study was to compare the clinical outcomes of EUS-guided ethanol ablation with those of the natural course (NC) of pancreatic cysts.
A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis
Authors: Masoud Tahmasian, Khadijeh Noori, Fateme Samea, Mojtaba Zarei, Kai Spiegelhalder, Simon B. Eickhoff, Eus Van Someren, Habibolah Khazaie, Claudia R. Eickhoff
Journal: Sleep Medicine Reviews (2018)
Prostate Cancer Diagnostics Using a Combination of the Stockholm3 Blood Test and Multiparametric Magnetic Resonance Imaging
Authors: Henrik Grönberg, Martin Eklund, Wolfgang Picker, Markus Aly, Fredrik Jäderling, Jan Adolfsson, Martin Landquist, Erik Skaaheim Haug, Peter Ström, Stefan Carlsson, Tobias Nordström
Journal: European Urology (2018)
PREDICTIVE FACTORS OF HIDDEN DEEP INFILTRATIVE CARCINOMA IN COLONIC LESIONS DERIVED FOR ENDOSCOPIC MUCOSAL RESECTION
Authors: M Sánchez Alonso, M Úbeda Muñoz, P Olivencia Palomar, E de la Santa Belda, J Olmedo Camacho, J Rodríguez Sánchez
Journal: Endoscopy (2018)

Tiny areas of deep infiltrating carcinoma in colorectal lesions can go unnoticed even on detailed examination with chromoendoscopy. Therefore, suspicion of this drawback should be taken into account in decision making. So, it is compulsory needed to determine predictive factors related to deep hidden infiltrating carcinoma (DHIC).
Incidencias técnicas (IT) durante la inserción transmural guiada por ecoendoscopia de Prótesis de Aposición Luminal (PAL) tipo Axios®
Authors: S Sevilla Ribota, J García Alonso, R Sánchez Ocaña, I Peñas Herrero, N Mora, I Becerro, R Torres Yuste, M Cimavilla, C De La Serna Higuera, M Pérez-Miranda
Journal: Endoscopy (2017)

Se han descrito anecdóticamente diversas IT durante la inserción de PAL, pero no están caracterizadas y se desconoce su frecuencia y relevancia.
Abstract 466: Cardiac Activation of β-catenin in Mice Leads to Prolongation of QRS and Susceptibility to Arrhythmia by Inhibiting Na <sup>+</sup> Channel Activity Through Suppression of Na <sub>V</sub> 1.5 Expression
Authors: Rong Huo, Chaowei Hu, Yan Lu, Ning Wang, Bo Ye, Arjun Deb, Faqian Li, Haodong Xu
Journal: Circulation Research (2017)

Introduction: In vitro studies showed that activation of β-catenin suppresses Na V 1.5 expression by inhibiting SCN5a promoter activity, leading to a decrease of Na + channel activity. How β-catenin regulates cardiac electrophysiological phenotype is unknown. Hypothesis: We hypothesized that cardiac activation of β-catenin regulates electrophysiological phenotype by suppressing Na V 1.5 expression. Methods: Adult mice with cardiac-specific, tamoxifen-induced deletion of β-catenin exon3 , leading to cardiac activation of β-catenin (β-catenin exon3 -/- ) were generated, and the effects of cardiac activation of β-catenin on the electrophysiological remodeling were assessed by electrocardiogram (ECG) recording. Class Ic antiarrhythmic reagent, flecainide, was administered to evaluate susceptibility to ventricular tachycardia (VT). Cardiac structure and function were evaluated by histologic and echocardiographic examinations, respectively. Western blot and qRT-PCR were performed to determine the levels of Na V 1.5 and β-catenin expression in mouse hearts. Whole-cell recording technique was utilized to record Na + currents and action potentials (APs) from ventricular myocytes. Results: Histologic and echocardiographic examinations showed that β-catenin exon3 -/- mice had normal cardiac structure and function. Compared to wild type (WT) mice, the ratio of heart/body weight was not changed and the duration of QRS was significantly prolonged in β-catenin exon3 -/- mice. VT was induced by flecainide in 60% of β-catenin exon3 -/- mice but not in WT mice. Western blot and qRT-PCR showed that Na V 1.5 protein and mRNA were significantly decreased in β-catenin exon3 -/- hearts, compared to WT hearts. Maximal upstroke velocity and amplitude of APs and Na + currents were significantly decreased in β-catenin exon3 -/- ventricular myocytes, compared to WT cells. Conclusion: Cardiac activation of β-catenin leads to prolongation of QRS and susceptibility to VT by decreasing Na V 1.5 expression and Na + channel activity.
Current and future treatment of hidradenitis suppurativa
Authors: K.R. van Straalen, S. Schneider‐Burrus, E.P. Prens
Journal: British Journal of Dermatology (2018)

This scholarly review on the current and future treatment of hidradenitis suppurativa (HS) focuses on medical and surgical treatment options, while novel pipeline drugs are also discussed. Treatment goals are to limit the incidence and duration of flares, reducing inflammation and suppuration, achieving local cure after surgery and, most importantly, to improve the quality of life of patients with HS. The type of medication and/or surgery should be chosen based on the stage of the disease and the degree of inflammation. However, the lack of a simple scoring system and the lack of clear surgical outcome definitions hamper the interpretation of treatment efficacy and the comparison between different treatment strategies. The therapeutic pipeline for HS is gradually expanding, and will probably lead to a broader panel of more effective therapeutic options.
Precisión diagnóstica y estimación de intervalos de seguimiento por usuarios inexpertos mediante la clasificación NICE en pacientes con pólipos colónicos &lt; 8 mm
Authors: I Manzano Santamaría, FJ García Alonso, A Guardiola Arévalo, A Gutiérrez Martín, M Alguacil Cuéllar, FJ Parra Villanueva, P Plaza Roig, MJ Reyes Larriba, A Posada Restrepo, F Bermejo
Journal: Endoscopy (2017)

Se han propuesto estrategias de resect and discard y diagnose and disregard en pólipos ≤5 mm. Para su implantación, se exige una precisión diagnóstica elevada mediante técnicas de cromoendoscopia.
DSM-III-R criteria for posttraumatic stress disorder
Authors: E A Brett, R L Spitzer, J B Williams
Journal: American Journal of Psychiatry (1988)

The authors describe the changes in DSM-III criteria for posttraumatic stress disorder (PTSD) that have been included in DSM-III-R. DSM-III-R includes specification of generic characteristics of traumatic stressors, clearer organization of symptoms around three dimensions of stress response (reexperiencing, avoidance and numbing, and physiological arousal), inclusion of symptoms specific to children, and specification of onset and duration of the disorder. The importance of these changes in the evolution of the diagnosis of PTSD is discussed.
CASE REPORT OF RECURRENT ACQUIRED VON WILLEBRAND FACTOR DEFICIENCY WITH HISTORY OF SEVERAL ENDOSCOPY EXAMINATIONS AND SMALL BOWEL RESECTIONS
Authors: M Fazekas, K Mullner, H Szekely, V Papp, P Miheller, L Madacsy, Z Tulassay, D Lippai
Journal: Endoscopy (2018)

A 59 years old man with overt gastrointestinal bleeding and iron-deficiency anemia visited our referral center with a history of several episodes of melena during 2010 – 2015. In 2012, he was operated upon and two short segments of small intestine were resected, surgical sample confirmed a prior CE diagnosis of angiodysplasia. After operation, gastrointestinal bleeding stopped for 2 years. In 2015 the patient experienced another episode of melena. Upper gastrointestinal endoscopy was negative for bleeding, lower gastrointestinal endoscopy was indicative of severe small intestinal bleeding. Subsequent CE examination showed one proximal and possible two distal bleeding areas with likelihood of several small intestinal angiodysplasias. During surgery two small bowel segments were again resected with histology specimens of angiodysplasia.
2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis
Authors: Anne-Kathrin Rausch Osthoff, Karin Niedermann, Jürgen Braun, Jo Adams, Nina Brodin, Hanne Dagfinrud, Tuncay Duruoz, Bente Appel Esbensen, Klaus-Peter Günther, Emailie Hurkmans, Carsten Bogh Juhl, Norelee Kennedy, Uta Kiltz, Keegan Knittle, Michael Nurmohamed, Sandra Pais, Guy Severijns, Thijs Willem Swinnen, Irene A Pitsillidou, Louise Warburton, Zhivko Yankov, Theodora P M Vliet Vlieland
Journal: Annals of the Rheumatic Diseases (2018)

Regular physical activity (PA) is increasingly promoted for people with rheumatic and musculoskeletal diseases as well as the general population. We evaluated if the public health recommendations for PA are applicable for people with inflammatory arthritis (iA; Rheumatoid Arthritis and Spondyloarthritis) and osteoarthritis (hip/knee OA) in order to develop evidence-based recommendations for advice and guidance on PA in clinical practice. The EULAR standardised operating procedures for the development of recommendations were followed. A task force (TF) (including rheumatologists, other medical specialists and physicians, health professionals, patient-representatives, methodologists) from 16 countries met twice. In the first TF meeting, 13 research questions to support a systematic literature review (SLR) were identified and defined. In the second meeting, the SLR evidence was presented and discussed before the recommendations, research agenda and education agenda were formulated. The TF developed and agreed on four overarching principles and 10 recommendations for PA in people with iA and OA. The mean level of agreement between the TF members ranged between 9.8 and 8.8. Given the evidence for its effectiveness, feasibility and safety, PA is advocated as integral part of standard care throughout the course of these diseases. Finally, the TF agreed on related research and education agendas. Evidence and expert opinion inform these recommendations to provide guidance in the development, conduct and evaluation of PA-interventions and promotion in people with iA and OA. It is advised that these recommendations should be implemented considering individual needs and national health systems.
Análisis de eficacia y seguridad en el uso rutinario de OTSC (Over-The-Scope Clip) en una unidad de endoscopia referente y centro terciario
Authors: AG Sumalla, F Bas-Cutrina, CF Consiglieri Alvarado, M Miró Martín, H Aranda Danso, L Farran Teixidó, JB Gornals Soler
Journal: Endoscopy (2017)

La aplicación de OTSC parece ser efectiva tanto en el sellado de orificios como medida antimigratoria de prótesis.
Antimicrobial Nanomedicine: Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives (Adv. Healthcare Mater. 13/2018)
Authors: Hüseyin Enis Karahan, Christian Wiraja, Chenjie Xu, Jun Wei, Yilei Wang, Liang Wang, Fei Liu, Yuan Chen
Journal: Advanced Healthcare Materials (2018)

Graphene materials have shown a fast growth as a new family of antibacterial agents in the last decade. The last five years of these investigations focused on the practical aspects. In article 1701406, Hüseyin Enis Karahan, Jun Wei, Yuan Chen and co-workers, outline the research progress in nanobiomedical applications of graphenes focusing on wound dressings, infection-protective implant surfaces, antibiotic-like formulations, and light-induced therapies.