tbuckley/cabot-search huggingface dataset:
Abstract 3229: Prediagnostic biomarkers of metabolic dysregulation and cancer mortality
Authors: Tomi Akinyemiju
Journal: Cancer Research (2018)

Abstract INTRODUCTION: The obesogenic milieu is a pro-tumorigenic environment that promotes tumor initiation, angiogenesis and metastasis. In this prospective cohort, we examined the association between pre-diagnostic metabolic biomarkers, plasma adiponectin, resistin, leptin and lipoprotein (a), and the risk of cancer mortality. METHODS: Prospective data was obtained from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort of Blacks and Whites followed from 2003 through 2012 for cancer mortality. We determined the association between metabolism biomarkers (log-transformed and tertiles) and risk of cancer mortality using Cox Proportional Hazards models with robust sandwich estimators to calculate the 95% confidence intervals (CIs), and adjusted for baseline covariates, including age, gender, income, education, physical activity, BMI, smoking status, alcohol use, and comorbidity score. RESULTS: Among 1764 participants with available biomarker data, each SD higher log-leptin was associated with a 54% reduced risk of total cancer mortality (HR: 0.46, 95% CI: 0.23 – 0.92) and obesity-related cancer mortality (HR: 0.55, 95% CI: 0.39-0.79). Among Blacks only, each SD higher log-resistin was associated with a nearly 7-fold increased risk of cancer mortality (adjusted HR: 6.68, 95% CI: 2.10 – 21.21). There were no significant associations of adiponectin or Lp(a) and cancer mortality. CONCLUSIONS: Leptin is involved in long-term regulation of energy balance, while resistin is involved in chronic inflammation and LDL production. These findings highlight the biological mechanisms linking metabolic dysregulation with cancer mortality, and the influence of resistin on cancer mortality only among Blacks suggests that this hormone may be a useful biomarker of racial differences in cancer mortality that deserves further study. Citation Format: Tomi Akinyemiju. Prediagnostic biomarkers of metabolic dysregulation and cancer mortality [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3229.
Abstract 5264: A prospective study of dietary inflammatory index scores and colorectal cancer risk: The Singapore Chinese Health Study
Authors: Hung N. Luu, Renwei Wang, Nittin Shivappa, James R. Hébert, Woon-Puay Koh, Jian-Min Yuan
Journal: Cancer Research (2018)

Abstract Background. Colorectal cancer (CRC) has increased dramatically in Singapore during the past three decades and becomes the most common cancer when both sexes combined. Extensive evidence shown the specific component of diet may modulate inflammation and thus influence to disease endpoints, including CRC. We determine the association between diet inflammatory index (DII)TM, a literature-derived, population-based score, developed to assess the inflammatory potential of an individual's diet, and CRC risk in Singaporean Chinese, using data from the Singaporean Chinese Health Study (SCHS). Methods. A total of 61,321 SCHS study participants was included in the current analysis. The DII scores were calculated using validated food frequency questionnaires (FFQs). Cox proportional hazards model was performed to assess the association between DII scores and CRC risk. Results. There was a positive association between DII score and CRC risk in females (HRs and respective 95% CIs: 1.30 (1.02-1.64), 1.32 (1.03-1.67), and 1.20 (0.93-1.55) for Q2, Q3, Q4 vs. Q1). DII score was associated with increased risk of colon cancer (HRQ4vsQ1=1.35, 95% CI: 1.08-1.68; Ptrend=0.04) and this association appeared stronger in females. Among never-smokers, the highest quartile of DII was associated with statically significant 43% increased risk of developing CRC in women compared to those in the lowest quartile (HRQ4vsQ1=1.43, 95% CI: 1.01-2.02; Ptrend=0.03). There was also a dose-response association between DII scores with colon cancer in women among those with BMI less than 25 (HRQ4vsQ1=1.66, 95% CI: 1.03-2.68; Ptrend=0.04). Conclusions. Consumption of anti-inflammatory foods will reduce the risk of colorectal cancer, particularly among females and non-smokers. This will have substantial public health impact as prevention program should focus on promoting healthy and anti-inflammatory foods to reduce the risk of colorectal cancer. Citation Format: Hung N. Luu, Renwei Wang, Nittin Shivappa, James R. Hébert, Woon-Puay Koh, Jian-Min Yuan. A prospective study of dietary inflammatory index scores and colorectal cancer risk: The Singapore Chinese Health Study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5264.
Prognosis of Retrograde Dissection From the Descending to the Ascending Aorta
Authors: ShuichiroKaji, TakashiAkasaka, MinakoKatayama, AtsushiYamamuro, KenjiYamabe, KoichiTamita, MakiAkiyama, NozomiWatanabe, KazuoTanemoto, ShigefumiMorioka, KiyoshiYoshida
Journal: Circulation (2003)

Background— Natural history of aortic dissection (AD) with intimal tear in the descending or abdominal aorta and retrograde extension into the ascending aorta (retrograde AD) remains unknown. The purpose of this study was to elucidate medium-term prognosis of patients with retrograde AD. Methods and Results— Study population consisted of 109 patients with acute type A AD. There were 27 patients (25%) with retrograde AD and 82 patients (75%) with intimal tear in the ascending aorta (antegrade AD). In antegrade AD patients, 60 patients underwent surgery and 22 patients were treated medically. In retrograde AD patients, 14 patients showed localized crescentic high attenuation area along the ascending aortic wall without enhancement in computed tomography. Transesophageal echocardiography revealed complete thrombosis of false lumen (FL) in the ascending aorta (retrograde thrombosed). The remaining 13 patients showed incomplete or no thrombosis (retrograde nonthrombosed). All retrograde nonthrombosed AD patien...
Abstract 1214: Nasopharyngeal carcinoma clinical stage, histologic grade and biomarker status at presentation are usually of poor prognostic characteristics: A clinicopathologic study in a low-resource setting
Authors: Aralola A. Olusanya, Gabriel O. Ogun, Adebolajo Adeyemo
Journal: Cancer Research (2018)

Abstract Introduction: Nasopharyngeal carcinoma (NPC) is the 8th commonest malignancy in men and the commonest head and neck tumor in Ibadan Cancer Registry (IBCR). Methods: Clinical files and records of all nasopharyngeal carcinoma diagnosed at the Department of Pathology, University College Hospital affiliated with IBCR between January 2007 and December 2016 were reviewed for demographic data, clinical presentation, clinical stage, histologic grade, LMP-1 and EGFR status. Results: A total of 71 cases of nasopharyngeal carcinoma were diagnosed during the study period, comprising 44 males and 27 females with a male:female ratio of 1.6. Age ranged from 12 years to 80 years, the modal age group was 40-49 and the modal age was 45 years. Sixty-three percent of cases were non-keratinizing undifferentiated tumors, 31% were non-keratinizing differentiated, 4.2% were keratinizing tumors and 1.4% basaloid squamous cell carcinoma. In all, non-keratinizing undifferentiated tumors constituted 64% of tumors in males and 63% in females. Conversely, non-keratinizing differentiated tumor was commoner in males, accounting for 34% of tumors compared to only 26% in females. Also, keratinizing tumor was twice as common in females than males; there was only a single basaloid squamous cell carcinoma recorded. The age group 30-39 years had the highest incidence of non-keratinizing undifferentiated tumor while non-keratinizing differentiated tumor was more common in the 40-49 age group. Patients presented most frequently with stage II disease, which accounted for 62% of cases. About 20% of these patients presented with stage IV disease. Nasal and aural symptoms accounted for the commonest presenting complaint, occurring in 38% of patients. Thirty-six percent presented with nasal symptoms alone while 13% had a combination of nasal, aural and visual symptoms; this group was mainly patients with stage IV disease. LMP-1 positivity was observed in as many as 99% of all cases. EGFR was positive in 94% of cases, indicating that NPCs are usually of poor prognosis in our practice setting at presentation. Conclusion: In our practice, nasopharyngeal carcinoma is characterized by late-stage presentation, high-grade histologic characteristics and have biomarker indicators of poor prognosis. Citation Format: Aralola A. Olusanya, Gabriel O. Ogun, Adebolajo Adeyemo. Nasopharyngeal carcinoma clinical stage, histologic grade and biomarker status at presentation are usually of poor prognostic characteristics: A clinicopathologic study in a low-resource setting [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1214.
Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease
Authors: Christopher M. Cook, Yousif Ahmad, James P. Howard, Matthew J. Shun-Shin, Amarjit Sethi, Gerald J. Clesham, Kare H. Tang, Sukhjinder S. Nijjer, Paul A. Kelly, John R. Davies, Iqbal S. Malik, Raffi Kaprielian, Ghada Mikhail, Ricardo Petraco, Firas Al-Janabi, Grigoris V. Karamasis, Shah Mohdnazri, Reto Gamma, Rasha Al-Lamee, Thomas R. Keeble, Jamil Mayet, Sayan Sen, Darrel P. Francis, Justin E. Davies
Journal: Journal of the American College of Cardiology (2018)

Recently, the therapeutic benefits of percutaneous coronary intervention (PCI) have been challenged in patients with stable coronary artery disease (SCD). The authors examined the impact of PCI on exercise responses in the coronary circulation, the microcirculation, and systemic hemodynamics in patients with SCD. A total of 21 patients (mean age 60.3 ± 8.4 years) with SCD and single-vessel coronary stenosis underwent cardiac catheterization. Pre-PCI, patients exercised on a supine ergometer until rate-limiting angina or exhaustion. Simultaneous trans-stenotic coronary pressure-flow measurements were made throughout exercise. Post-PCI, this process was repeated. Physiological parameters, rate-limiting symptoms, and exercise performance were compared between pre-PCI and post-PCI exercise cycles. PCI reduced ischemia as documented by fractional flow reserve value (pre-PCI 0.59 ± 0.18 to post-PCI 0.91 ± 0.07), instantaneous wave-free ratio value (pre-PCI 0.61 ± 0.27 to post-PCI 0.96 ± 0.05) and coronary flow reserve value (pre-PCI 1.7 ± 0.7 to post-PCI 3.1 ± 1.0; p < 0.001 for all). PCI increased peak-exercise average peak coronary flow velocity (p < 0.0001), coronary perfusion pressure (distal coronary pressure; p < 0.0001), systolic blood pressure (p = 0.01), accelerating wave energy (p < 0.001), and myocardial workload (rate-pressure product; p < 0.01). These changes observed immediately following PCI resulted from the abolition of stenosis resistance (p < 0.0001). PCI was also associated with an immediate improvement in exercise time (+67 s; 95% confidence interval: 31 to 102 s; p < 0.0001) and a reduction in rate-limiting angina symptoms (81% reduction in rate-limiting angina symptoms post-PCI; p < 0.001). In patients with SCD and severe single-vessel stenosis, objective physiological responses to exercise immediately normalize following PCI. This is seen in the coronary circulation, the microcirculation, and systemic hemodynamics.
One-Year Outcomes after PCI Strategies in Cardiogenic Shock
Authors: Holger Thiele, Ibrahim Akin, Marcus Sandri, Suzanne de Waha-Thiele, Roza Meyer-Saraei, Georg Fuernau, Ingo Eitel, Peter Nordbeck, Tobias Geisler, Ulf Landmesser, Carsten Skurk, Andreas Fach, Alexander Jobs, Harald Lapp, Jan J. Piek, Marko Noc, Tomaž Goslar, Stephan B. Felix, Lars S. Maier, Janina Stepinska, Keith Oldroyd, Pranas Serpytis, Gilles Montalescot, Olivier Barthelemy, Kurt Huber, Stephan Windecker, Lukas Hunziker, Stefano Savonitto, Patrizia Torremante, Christiaan Vrints, Steffen Schneider, Uwe Zeymer, Steffen Desch
Journal: New England Journal of Medicine (2018)

Among patients with acute myocardial infarction, cardiogenic shock, and multivessel coronary artery disease, the risk of a composite of death from any cause or severe renal failure leading to renal-replacement therapy at 30 days was found to be lower with percutaneous coronary intervention (PCI) of the culprit lesion only than with immediate multivessel PCI. We evaluated clinical outcomes at 1 year.
Improving on Tail-of-the-Curve Evaluation With the American Society of Clinical Oncology Value Framework—Reply
Authors: Omer Ben-Aharon, Daniel A. Goldstein
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Response to: ’Dual target strategy: a proposal to mitigate the risk of overtreatment and enhance patient satisfaction in rheumatoid arthritis' by Ferreira <i>et al</i>
Authors: Robert B M Landewé
Journal: Annals of the Rheumatic Diseases (2018)

I thank Dr Ferreira and colleagues1 for their thoughtful response to Overdiagnosis and Overtreatment ,2 which I entirely agree with and to which I will briefly comment, since their proposal may have important clinical connotations. They argue among others that patient-reported outcomes should better be separated from objective measures for disease activity since the former do not always reflect the inflammatory process itself, a valid argument.

Our classic vision on signs and symptoms in diseases like rheumatoid arthritis (RA) has always been rather unidimensional, with which I mean that we implicitly assign most signs and symptoms reported by patients to the inflammatory (immunological) dysregulations. This has always worked well in clinical trials because patients with high levels of …
Abstract 15013: A Rise in Systolic Pulmonary Arterial Pressure at Low Level of Exercise Predicts Prognosis in Asymptomatic Patients With Organic Mitral Regurgitation -Results From the PROGRAM Study
Authors: Oumhani Toubal, Haifa Mahjoub, Christophe Thébault, Catherine Bélanger, Nancy Côté, Marie-Annick Clavel, Julien Magne, Abdelaziz Dahou, Kim O’Connor, Jonathan Beaudouin, Mathieu Bernier, Florent Le Ven, Philippe Pibarot
Journal: Circulation (2016)

Introduction: The optimal timing of mitral valve surgery in asymptomatic patients with chronic severe organic mitral regurgitation (MR) is controversial. Exercise-induced pulmonary arterial hyperte...
Evaluation of the stage IB designation of the 7th edition of the AJCC Staging System.
Authors: Nikolaos Andreas Dallas, Min Yi, Kelly Hunt, Ruchita R. Shah, Henry Mark Kuerer, Jennifer Keating Litton, Yun Wu, Abigail Suzanne Caudle, Funda Meric-Bernstam, Aysegul A. Sahin, Elizabeth Ann Mittendorf
Journal: Journal of Clinical Oncology (2012)

1130 Background: Recent data from large cooperative group trials have questioned the relevance of small volume metastases identified in the sentinel lymph nodes (SLN) of early stage breast cancer patients. The 7 th ed. of the AJCC staging system differentiates node negative patients (stage IA) from those with micrometastases (stage IB) or macrometastases (stage II or III). This study was undertaken to determine the utility of the stage IB designation. Methods: Review of a prospectively maintained database identified 3474 patients who underwent SLN biopsy between 1993 and 2007. Clinicopathologic and outcomes data were recorded and patients staged according to the 7 th ed. AJCC system. Recurrence-free (RFS), disease-specific (DSS) and overall survival (OS) were determined using the Kaplan-Meier method and compared using the log-rank test. Results: AJCC stage distribution included: 2246 (65%) stage IA, 207 (6%) stage IB, 685 (20%) stage IIA, 209 (6%) stage IIB, and 127 (3%) stage III. For patients with stage IB disease, SLN micrometastasis was identified by H&amp;E in 173 (84%) and immunohistochemistry (IHC) in 34 (16%); suggesting that 16% would have been staged IA if enhanced evaluation had not been performed. Median follow-up was 6.1 yrs (range 0-17.2). The 5-yr RFS,DSS and OS rates for patients with stage IB disease were 98.0%, 99.5%, and 95.9% respectively, which did not differ significantly from patients with stage IA disease who had 5-year RFS,DSS and OS rates of (97.5%, p=.9), (98.8%, p=.7) and (96.2%, p=.8). When all stage I patients (IA and IB) were evaluated by ER status or grade (grade 1 vs 2 vs 3), these biologic factors were able to significantly discriminate patients with respect to RFS, DSS and OS. Conclusions: Differentiating patients with micrometastases from node negative patients does not stratify patients with respect to survival. Biologic factors (ER status and grade) are better discriminants of survival than the presence of small volume nodal metastases in patients with early stage disease. These data do not support routine use of IHC or alterations in adjuvant therapy decisions based on identification of SLN micrometastases.
Abstract 15490: Immunogenic Verification of MHC-homo iPS Cell-derived Cardiomyocytes Transplantation to an MHC-matched Non-human Primate Ischemic Cardiomyopathy Model: Pre-clinical Study for Allogenic Therapy Using iPS Cells
Authors: Noriyuki Kashiyama, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Shigeo Masuda, Takuji Kawamura, Ai Kawamura, Shohei Yoshida, Takayoshi Ueno, Koichi Toda, Toru Kuratani, Yoshiki Sawa
Journal: Circulation (2015)

Introduction: Derivatives of allogeneic induced pluripotent stem cell (iPSC) are promising in clinical application of iPSC-based cardiac regeneration therapy. Although major histocompatibility complex (MHC)-matched allogeneic implantation (MMAI) is theoretically useful in minimizing immune rejection against the graft, graft survival or therapeutic efficacy of MMAI is poorly understood. Hypothesis: We herein hypothesized that MMAI of iPSC-derived cardiomyocytes (CM)-sheet may be therapeutically effective in a non-human primate ischemic cardiomyopathy model. Methods: iPSCs constitutively expressing GFP were established from Macaca fascicularis with homozygous MHC haplotypes, named “HT1”. Cardiomyogenic differentiation was induced in vitro. Heterozygous HT1 Macaca fascicularis ischemic model was made by ligation of left anterior descending artery (LAD) for 2 weeks, followed by transplantation of the derivatives containing 1.0х107 cells to the cardiac surface as MMAI with tacrolimus, mycophenolate mofetil and prednisolone given. Results: LAD ligation for 2 weeks successfully resulted in decrease of left ventricular ejection fraction (LVEF, 50.4±0.5% to 24.9±1.6%), increase of LV end-systolic volume (ESV, 3.2±0.4 mL to 8.2±0.4 mL) and LV global wall stress (GWS, 106±8 kdyne/cm2 to 203±22 kdyne/cm2). At 4 weeks after transplantation, GFP intensity of the graft was 3.6-fold greater in the MMAI group than the sham, although GFP intensity was not different between the two at 2 months, as assessed by stereomicroscope. LVEF, LVESV and GWS were recovered in the MMAI group at 1 month after the transplantation and then preserved until 5 months (LVEF; 32.4% and 33.8%, LVESV; 7.1 and 7.8 mL, GWS; 156.4 and 165.9 kdyne/cm2, respectively), whereas the sham group showed progressive functional deterioration at 1 and 5 months (LVEF; 20.9% and 21.5%, LVESV; 9.2 and 11.6 mL, GWS; 218.6 and 265.3 kdyne/cm2, respectively). Conclusions: Ischemic cardiomyopathy model was established in a non-human primate, for which MHC-homo-iPSCs-CM sheets were successfully transplanted as MMAI, inducing functional recovery with persistent presence of the graft. It was suggested that MHC-homo-iPSCs may be useful to realize iPSC-based cardiac regenerative therapy.
Association of Nausea and Vomiting in Pregnancy With Prenatal Marijuana Use
Authors: Kelly C. Young-Wolff, Varada Sarovar, Lue-Yen Tucker, Lyndsay A. Avalos, Amy Conway, Mary Anne Armstrong, Nancy Goler
Journal: JAMA Internal Medicine (2018)

This observational study of a health care system population assessed whether prenatal marijuana use is elevated among women with nausea and vomiting in pregnancy who underwent universal screening for marijuana use.
Abstract 21351: Intravascular Ultrasound-Guided vs. Angiography-Guided Intervention in Coronary CTO: Report From a Seven Year National Data
Authors: Prashant Patel, Nirali Patel, Sopan Lahewala, Shilpkumar Arora, Byomesh Tripathi, Varun Kumar, Apurva Badheka
Journal: Circulation (2017)

Background: Intravascular ultrasound (IVUS) has been used for a long time to guide percutaneous coronary intervention in different subsets of coronary lesions and could be used to navigate guidewire within the CTO segment. However, previously published national data demonstrating the role of IVUS in CTO appears sparse. Methods: HCUP’s Nationwide Inpatient Sample (NIS) database from 2008-2014 was utilized to identify CTO (414.2), IVUS (00.24) and PCI using appropriate ICD-9 codes. Logistic regression analysis was used to adjust for confounders for our outcome variable of inpatient mortality. Result: 878112 CTO admissions were identified during study period, of which 47.6% went for revascularization with PCI (26.7% female, 69.8% white, and 51.1% age ≥ 65). IVUS was used in 5.4 %(22730) of these CTO PCI. Univariate anlaysis revealed significantly different distribution of baseline risk factors (Table 1a). In hospital mortality was lower (1.86% vs 2.99%, p&lt;0.0001) in IVUS group. Cost of care was higher in IVUS group while there was no difference in length of stay. After adjusting for confounders, in our multivariable analsis, use of IVUS was associated with reduced odds (0.64, CI 0.49-0.84, p=0.0012) of in hospital mortality(Table 1b). Conclusion: Intravascular ultrasound imaging was associated with lower in-hospital mortality compared to conventional angiographic approach in recanalization of CTO in this large national representative sample. Further research exploring role of IVUS in other outcomes such as procedural complications may establish it as an intergral part of CTO PCI.