tbuckley/cabot-search huggingface dataset:
Cancer-related fatigue in cancer survivors (CS) with no active treatment.
Authors: Maria Soriano, Alejandro Alvarez-Bustos, Javier Ramos, Carmen Piquin, Pablo Osorio, Javier Ros, Miguel Ramírez, Lourdes Gutierrez Sanz, Beatriz Nuñez García, Raquel Gomez-Bravo, Lidia Brea, Carmen Fiuza-Luces, Alejandro Lucia, Itziar Pagola, Hector Cebolla, Ana Ruiz-Casado
Journal: Journal of Clinical Oncology (2017)

238 Background: Fatigue is a subjective experience that should be systematically assessed at the initial visit, at regular intervals and as clinically indicated. Quality of fatigue management should be included in institutional continuous quality improvement projects. The PERFORM questionnaire (PQ) was developed among Spanish speaking patients for the assessment of fatigue. Methods: Outpatients recruited for projects in which physical condition and physical activity (PA) were evaluated, rated their fatigue severity on the PQ (12-60, being 60 no fatigue). PHUEM-01 evaluated early colon CS after finishing adjuvant treatment (AT). PHUEM-02 early breast CS at the end of AT. PH-UEM-03 evaluated colorectal CS (localized and metastatic) at the time of diagnosis. MS-04 evaluated fatigue at the time of diagnosis of different tumors (localized and metastatic). Physical condition was evaluated through the one-mile walk test (VO 2MAX ) and handgrip dynamometer. Heart rate was measured as a sign of autonomic dysfunction. PA was objectively evaluated through accelerometers generating weekly MVPA information. Results: 262 CS (63% women) were recruited, (110 breast, 119 colorectal, 14 other), mean age 60. 30% of survivors reported no fatigue. Mean PERFORM score 48,34; VO 2max 25.5 ml/kg/min; handgrip 29,14 kg; HR 75 bpm. Women, younger CS, CS with worse physical condition, higher BMI, higher HR and less active CS reported more fatigue (only sex, handgrip strength and weekly PA were statistically significant for the overall population). Breast CS reported higher scores of fatigue than colorectal CS (p &lt; 0.000). For breast CS there was an association between fatigue and HR which was not seen in the overall population. Metastatic colorectal did not report worse scores of fatigue than CS with localized tumors. Conclusions: As a subjective symptom, fatigue is unpredictable and its severity and interference with daily activities can be bothersome in an unexpected population (young CS, early stages) with no active treatment. More physically active and fitter CS are less fatigued. Mechanisms underlying cancer-related fatigue could be different for different tumors. More research in prevalence, evaluation, mechanisms and management of fatigue is needed.
New indications for fully covered lumen-apposing metal stents: biliary stenting to treat post-sphincterotomy bleeding or ampullary stenosis
Authors: Gianfranco Donatelli, Jean-Loup Dumont, Serge Derhy, Bruno Meduri, Stavros Dritsas, Brice Gayet, David Fuks
Journal: Endoscopy (2017)

Stenting with standard biliary fully covered self-expandable metal stents (FCSEMSs) has been reported as successful treatment for complications after biliary sphincterotomy such as bleeding, perforation, or stenosis [1]. However, in some situations, such as a dilated common bile duct (CBD) or large sphincterotomy, these stents are not watertight, which can lead to persistent bleeding and leakage, or a malfunction [1] [2]. A new, shaped, large covered stent could be an interesting solution, with maximal radial and axial force achieving adequate local compression to allow calibration of a stenosis, hemostasis, or a watertight seal to be created [3] [4]. Here, we report our early experience with the use of these new stents in the CBD in two patients ([Video 1]).
Reply to the letter to the editor ‘Re-aligning the ASCO and ESMO clinical benefit frameworks or modern cancer therapies’
Authors: N.I. Cherny, U. Dafni, J. Bogaerts, N.J. Latino, G. Pentheroudakis, J.-Y. Douillard, J. Tabernero, C. Zielinski, M.J. Piccart, E.G.E. de Vries
Journal: Annals of Oncology (2017)
On the nature of structure in structural priming
Authors: Nayoung Kwon, Yoonhyoung Lee
Journal: Behavioral and Brain Sciences (2017)

Abstract Like Branigan &amp; Pickering (B&amp;P), we agree that processing evidence is important for linguistic theorization; however, without much evidence of priming of hierarchical argument structure independent of linear ordering, the nature of “structure” in structural priming remains unclear. Consequently, it is an empirical question whether structural priming and acceptability judgments tap into cognitive processes of a similar nature.
PCR method for detection of EGFR exon 19 deletion in NSCLC
Authors: Michio Sugita, Eiji Nakajima, Harubumi Kato, Paul Bunn, Wilbur Franklin, Fred Hirsch
Journal: Cancer Research (2007)

394  Back ground. The response rate of non-small cell lung carcinoma to EGFR tyrosine kinase inhibitors (TKI) is approximately 10%. Recently, somatic mutations in EGFR exon 18-21 (TK domain) have been associated with response to TKI treatment but only deletions in exon 19 have been predictive of survival. It therefore may be important to identify exon 19 mutations in selecting patients for targeted treatment. Direct sequencing to identify EGFR TK domain mutations is time consuming and cost inefficient. We have developed a simple, PCR-based method to detect exon 19 deletion mutations as a potentially cost effective and sensitive method for identifying those NSCLC patients for whom TKI treatment may offer survival benefit.  Materials and Methods. A total of 9 NSCLC lines, 5 with known mutations (H827, H1650, H2279, H3255 and HCC4006) and 4 without mutations (H157, H460, H520 and A549) 4 clinical tumor samples were tested in this pilot study. Tumor tissue was microdissected under stereoscopic microscopy from formalin-fixed paraffin-embedded sections and DNA was extracted from tumor cells with DNeasy (Qiagen). A semi-nested PCR procedure was employed to amplify exon 19 DNA in which the first round primers (27 cycles) were placed in the introns encompassing the whole of exon 19. Template from the first round was amplified with two additional primer sets, one encompassing a 126 bp segment containing all exon 19 deletions so far reported and second primer set in which one primer was set across the most common mutation (del E746-750A). PCR products were separated on 2.5% low range ultra agarose (Bio-Rad) and visualized by UV transillumination of gels stained with ethidium bromide.  Results. Successful detection of known mutations was achieved in samples as small as 40 picograms of purified DNA and at mutant to wild type DNA copy ratios (M/W) of 1/600. The M/W in PCR products was not consistent even in cell lines with deletion. All of the known deletions present in the cell lines were detected by this assay and none of the non-mutant tumors were positive (100% concordance with published data). The assay detected mutations in 2 of the 4 clinical samples tested. In one cell line and one clinical sample, the detected deletion was of an uncommon type.  Conclusions. This PCR-based EGFR deletion assay is sensitive for all known mutations in exon 19. It can be performed on paraffin embedded tissue samples rapidly and may be economical for large scale screening of clinical samples.
E' in aumento il numero delle infezioni gonococciche identificate dalla rete RENAGO
Authors: V Goulet, P Sednaoui, A Laporte, C Billy, J C Desenclos
Journal: Eurosurveillance (2000)

In Francia, la sorveglianza delle infezioni sessualmente trasmesse (IST) e basata principalmente sulle notifiche di laboratorio, poiche le IST non sono tra le malattie notificate dai medici (1). Nel 1986, e stata creata la rete RENAGO (Reseau National du Gonocoque) con lo scopo di monitorare l'andamento nazionale delle infezioni gonococciche e la sensibilita dei ceppi di Neisseria gonorrhoeae agli antibiotici. Fino al 1992, la rete e stata composta da 100 laboratori e, dal 1993, quando la rete e stata estesa in maniera da comprendere laboratori specializzati (quelli in collaborazione con le cliniche di medicina genitourinaria - GUM - o con medici specializzati in IST), ne ha coinvolti circa 200.
Yield, quality, kinetics and thermodynamics studies on extraction of Thevetia peruviana oil from its oil bearing seeds
Authors: J. M. Jabar, L. Lajide, A. O. Adetuyi, B. J. Owolabi, I. O. Bakare, T. G. Abayomi, A. L. Ogunneye
Journal: Journal of Clinical Oncology (2015)

The present research shows possibility of extracting Thevetia peruviana oil from its oil bearing seeds by cold and soxhlet extraction methods, using petroleum ether as extracting solvent at room temperature and 40 to 60°C respectively. Characterisation of the oil showed that the percentage oil yield, acid value, saponification value and viscosity increased as temperature of soxhlet extraction increased, while the specific gravity and iodine value of the extracted oil decreased at high temperature of extraction in soxhlet extraction method. Cold extraction showed improved quality and oil yield, in comparison with oil obtained from soxhlet extraction method. The kinetics of the oil extracted from soxhlet extraction method was derived from mass transfer rate equation and was found to fit well with only pseudo-second order kinetic of volumetric mass transfer rate coefficient 0.04 h-1. The thermodynamics study of the extracted oil showed that âˆ†H and âˆ†S were positive while âˆ†G was negative, indicating that T. peruviana oil extraction process was endothermic, spontaneous and irreversible with exception to extraction at 40 and 45°C.

	                                                                                                       

	Key words: Extraction, irreversible, kinetic, thermodynamic, quality.
In suspected PE, 2% of patients with a Wells score &gt; 4 and negative CT pulmonary angiography had VTE at 3 months
Authors: Michael A. Kohn
Journal: Annals of Internal Medicine (2017)

Source Citation van der Hulle T, van Es N, den Exter PL, et al. Is a normal computed tomography pulmonary angiography safe to rule out acute pulmonary embolism in patients with a likely clinical probability? A patient-level meta-analysis. Thromb Haemost. 2017;117:1622-9. 28569924
Abstract 16739: A Simplified Dichotomous Phenotypic Classification of Bicuspid Aortic Valve Using the Orientation of Coronary Arteries Shows Better Association With Type of Valvulopathy and Combined Aortopathy
Authors: Byung Joo Sun, Sahmin Lee, Jeong Yoon Jang, Hanul Choi, Xin Jin, Ji Hye Lee, Se Hun Kang, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song
Journal: Circulation (2015)

Background: Recently introduced dichotomous phenotypic classification of bicuspid aortic valve (BAV) showed potential association between BAV phenotype and patterns of valvulopathy or aortopathy. However its potential advantage needs to be compared with the conventional BAV classification in a large patient population. Methods: In 486 consecutive patients (309 male, 58±14 years) who underwent aortic valve (AV) surgery (n=483) or aortic surgery (n=146), BAV phenotype was classified using echocardiography. Dichotomous classification was based on the orientation of coronary arteries: AP (both coronary arteries originating from the anterior cusp) and RL (each coronary artery originating from each cusp). Conventional classification (type 1 - 4) was based on the fused cusp (Figure). We analyzed the associations between the BAV phenotype and 1) indication of AV surgery (aortic stenosis [AS] vs. regurgitation [AR]), and 2) implementation of aortic surgery. Results: BAV-AP (n=271, 56%) was more common than BAV-RL (n=215, 44%). Using conventional classification, fused cusps were indistinguishable in 15% (type 4). Indications of AV surgery included dominant AS (n=352), AR (n=96), and infective endocarditis (IE; n=35). Aortic surgeries were performed for aortic aneurysm (n=135), IE with abscess (n=9), dissection (n=1), and coarctation (n=1). Patients with BAV-RL type presented lower frequency of male (55% vs. 70%, P=0.001), AV surgery for dominant AS (82% vs. 66%, P&lt;0.001), and more frequent aortic surgery (36% vs. 25%, P=0.007) compared to those with BAV-AP. In multivariate analyses, the BAV-RL in dichotomous classification showed more clear association with 1) surgery for dominant AS and 2) aortic surgery compared to the corresponding groups in conventional classification (Figure). Conclusions: New classification can overcome the ambiguity of the conventional classification and shows better association with type of valvulopathy and combined aortopathy.
P3.02b-033 Filter Paper as Specimen Storage and Transport Medium of EGFR Mutation Testing Collected from Lung Cancer Patients in Remote Areas of Indonesia
Authors: Asep Ridwanuloh, Jamal Zaini, Sita Andarini, Achmad Hudoyo, Heriawaty Hidajat, Ahmad Utomo, Najmiatul Masykura
Journal: Journal of Thoracic Oncology (2017)
Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection
Authors: Yuan Wang, Xin Tan, Hai Gao, Hui Yuan, Rong Hu, Lixin Jia, Junming Zhu, Lizhong Sun, Hongjia Zhang, Lianjun Huang, Dong Zhao, Pei Gao, Jie Du
Journal: Circulation (2017)

Misdiagnosis of acute aortic dissection (AAD) can lead to significant morbidity and death. Soluble ST2 (sST2) is a cardiovascular injury-related biomarker. The extent to which sST2 is elevated in AAD and whether sST2 can discriminate AAD from other causes of sudden-onset severe chest pain are unknown.We measured plasma concentrations of sST2 (R&D Systems assay) in 1360 patients, including 1027 participants in the retrospective discovery set and 333 patients with initial suspicion of AAD enrolled in the prospective validation cohort. Measures of discrimination for differentiating AAD from other causes of chest pain were calculated.In the acute phase, sST2 levels were higher in patients with AAD than those with either acute myocardial infarction in the first case-control discovery set within 24 hours of symptom onset or with patients with pulmonary embolism in the second discovery set (medians of 129.2 ng/mL versus 14.7 with P<0.001 for AAD versus acute myocardial infarction and 88.6 versus 9.3 with P<0.001 for AAD versus pulmonary embolism). In the prospective validation set, sST2 was most elevated in patients with AAD (median [25th, 75th percentile]: 76.4 [49.6, 130.3]) and modestly elevated in acute myocardial infarction (25.0 [15.5, 37.2]), pulmonary embolism (14.9 [10.2, 30.1]), and angina patients (21.5 [13.1, 27.6], all P<0.001 versus AAD). The area under receiver operating characteristic curve for patients with AAD versus all control patients within 24 hours of presenting at the emergency department was 0.97 (0.95, 0.98) for sST2, 0.91 (0.88, 0.94) for D-dimer, and 0.50 (0.44, 0.56) for cardiac troponin I, respectively. At a cutoff level of 34.6 ng/mL, sST2 had a sensitivity of 99.1%, specificity of 84.9%, positive predictive value of 68.7%, negative predictive value of 99.7%, positive likelihood ratio of 6.6, and negative likelihood ratio of 0.01.Among patients with suspected aortic dissection in the emergency department, sST2 showed superior overall diagnostic performance to D-dimer or cardiac troponin I. Additional study is needed to determine whether sST2 might be a useful rule-out marker for AAD in the emergency room.
Flu vaccine reduces children’s admissions for respiratory complications, study shows
Authors: Susan Mayor
Journal: BMJ (2017)

Young children who are vaccinated against influenza are less likely to be admitted to hospital for respiratory complications of flu infection than children who are not vaccinated, a large Canadian study has reported.

“Influenza can cause serious illness, especially in young children, but there hasn’t been a lot of research that has examined the magnitude of the influenza …
Survival Without Cardiac Transplantation Among Children With Dilated Cardiomyopathy
Authors: Rakesh K. Singh, Charles E. Canter, Ling Shi, Steven D. Colan, Debra A. Dodd, Melanie D. Everitt, Daphne T. Hsu, John L. Jefferies, Paul F. Kantor, Elfriede Pahl, Joseph W. Rossano, Jeffrey A. Towbin, James D. Wilkinson, Steven E. Lipshultz
Journal: Journal of the American College of Cardiology (2017)
Walking: a best buy for public and planetary health
Authors: Fiona C Bull, Adrianne E Hardman
Journal: British Journal of Sports Medicine (2017)

This special issue of the  British Journal of Sports Medicine marks the 21st anniversary of the publication of the seminal review paper Walking to Health by Morris and Hardman, which presented an elegant synthesis of the health benefits of walking, a broad and complex field of scientific enquiry.1 It concisely summarised the extensive physiological, metabolic and other health-related impacts of different patterns of walking across all ages, and also positioned this knowledge in the wider context of national public health efforts by providing practical and policy-relevant recommendations. The simplicity of its title reflects its core finding—walking is good for health. At all ages, for primary and secondary prevention, to save healthcare costs, for individuals to live their lives with the full potential of good health, to create better communities and to improve the environment, walking offers a solution.

Providing guidance on how to use science in practical actions and to inform public policy may seem very contemporary, and for some an uncomfortable necessity, but communicating science so it could inform policy was a hallmark of the authors’ contribution to their respective fields of social epidemiology and exercise science. Those new to this field are encouraged to find time to read the original paper, in particular to see just how much we already knew back then. In 1997 as a final-year doctorate student, the first author (FCB) distinctly recalls the arrival of this review article by way of a library request. Back then, and certainly in Australia, not all journal articles were as readily available as they are today. Reading it was both rewarding and reinforcing because integrating the discipline of exercise science with the field …
Alargando horizontes, abrindo portas
Authors: S Handysides
Journal: Eurosurveillance (1999)

Este numero do Eurosurveillance inclui um artigo cuja publicacao no boletim requer alguma explicacao. A asma nao e uma doenca infecciosa mas as infeccoes virais agudas sao, reconhecidamente, um factor desencadeante de crises asmaticas e as pessoas que sofrem de asma estao mais susceptiveis a ataques prolongados de ‘bronquite aguda’, cujo tratamento pode ser diferente do aplicado na bronquite aguda de pessoas sem asma.
Abstract 21075: Heat Shock Factor 1 Modulates Exosomes Biogenesis and Cargo
Authors: Sudhish Sharma, Grace Bigham, Progyaparamita Saha, Rachana Mishra, Sonia Draggulin-Otto, Philip Zachary-Brohawn, Laxminarayan Korutla, Prashanth Vallabhajosyula, Sotirios Karathanasis, Sunjay Kaushal
Journal: Circulation (2017)

Introduction: Cardiac Progenitor cells (CPCs, identified by ckit+/CD45-/lin-) are being used in 21 clinical trials (recruiting and completed) to restore heart function and promote tissue regeneration in response to injury and their exosomes (EXO) has been identified to be critical for their functional activity. Hypothesis: We hypothesized that heat shock factor 1 (HSF1) modulates EXO biogenesis from CPCs and their enrichment with therapeutic miRs. Methods and Results: EXOs were isolated from cultured CPCs, generated from the biopsies of right atrial appendage (RAA) at the time of cardiac surgery from neonatal (nCPCs, &lt; 1 month) and adult (aCPCs, &gt; 40 years) patients with normal functioning myocardium using size exclusion chromatography (CL-2B). EXOs were analyzed by transmission electron microscopy, Nanosight (LM10) and the flow cytometry for EXO markers as CD63 and ALIX. Our results showed that physiological changes as ageing affects EXOs biogenesis and their functional potential as nCPCs generate significantly more EXOs than aCPCs. HSF1 overexpression in aCPCs significantly enhanced their EXO biogenesis. nCPCs derived EXOs (nEXOs) are significantly more effective (nEXOs 62.14±2.9% vs aEXO 56 ± 3.6%, p&lt;0.05) to improve cardiac function and tissue repair in a myocardial infarction (MI) model in rats as compared to aCPCs derived EXOs. In a rat MI model, using florescent labelled HLA-A antibodies, nEXOs were identified to be retained for longer duration in rat serum as compared to aEXOs, which correlated with myocardial functional recovery. miRNA sequencing of EXOs identified significantly higher expression of cardio protective miRs like miR199a, 146a, 454, 590, 130a in nEXOs as compared to aEXOs. We also identified that HSF1 overexpression in aCPCs significantly enriched them with miR199a, miR130a and miR590 suggesting that HSF1 can affect EXO biogenesis and its miR Cargo. The results of large scale production of EXOs using hollow fibre systems will also be presented. Conclusion: We showed that nEXOs are functionally more active and modulation of HSF1 can affect EXOs biogenesis and its cargo from CPCs. These results also suggest that nEXOs has the potential to be utilized as an off the shelf cell-free therapy.
Experimental design and quantitative analysis of microbial community multiomics
Authors: Himel Mallick, Siyuan Ma, Eric A. Franzosa, Tommi Vatanen, Xochitl C. Morgan, Curtis Huttenhower
Journal: Genome biology (2017)

Studies of the microbiome have become increasingly sophisticated, and multiple sequence-based, molecular methods as well as culture-based methods exist for population-scale microbiome profiles. To link the resulting host and microbial data types to human health, several experimental design considerations, data analysis challenges, and statistical epidemiological approaches must be addressed. Here, we survey current best practices for experimental design in microbiome molecular epidemiology, including technologies for generating, analyzing, and integrating microbiome multiomics data. We highlight studies that have identified molecular bioactives that influence human health, and we suggest steps for scaling translational microbiome research to high-throughput target discovery across large populations.
Prevalence and association of microsatellite instability with PD-L1 expressions in colorectal cancer patients treated in an Indonesian private hospital
Authors: A. Sudoyo, A.N. Kurniawan, A. Budiyati, G. Kusumo, T.P. Putra, A. Utama, F. Rexana, A.R. Utomo
Journal: Annals of Oncology (2017)
Real-world experience with FOLFIRINOX and gemcitabine plus nab-paclitaxel in the treatment of pancreatic cancer in Japan
Authors: O. Maeda, Y. Yokoyama, J. Yamaguchi, A. Ota, A. Matsuoka, S. Morita, M. Inoue, T. Mizutani, T. Shimokata, H. Urakawa, A. Mitsuma, M. Nagino, Y. Ando
Journal: Annals of Oncology (2017)
P2.07-020 Distinct Immune Status in Patients with Adenocarcinoma and Squamous Cell Carcinoma: Implication for Immunotherapy of NSCLC
Authors: N. Hradilova, O. Palata, L. Sadilova, D. Myšíková, H. Mrazkova, R. Lischke, R. Špíšek, I. Adkins
Journal: Journal of Thoracic Oncology (2017)
Mismatch repair deficiency (MMRD) and PD-L1 expression in high grade glioma (HGG) patients from Siloam Hospital Jakarta Indonesia
Authors: D. Patricia, J. July, E.J. Wahjoepramono, G. Prayogi, Z.G. Wuisan, D. Budhiarko, T.P. Putra, N. Masykura, A.R. Utomo
Journal: Annals of Oncology (2017)