tbuckley/cabot-search huggingface dataset:
Abstract #2376: The establishment of a streptozocin-induced mouse pulmonary tumor model.
Authors: Toshiya Kuno, Masanao Yokohira, Nozomi Hashimoto, Satoshi Suzuki, Kousuke Saoo, Katsumi Imaida
Journal: Cancer Research (2009)

Object: Streptozocin (STZ), which is glycoside of methylnitrosourea, selectively destroys pancreatic beta cells and has been the agent of choice for the induction of diabetes mellitus in animals ever since. It is thought that STZ accumulate in pancreatic beta cells via GLUT2 glucose transporter in the plasma membrane. Recently, GLUT2 mRNA and protein were detected in human lung polarised cells. Thus, we investigated the effects of STZ in female A/J mice and evaluate the diabetic potency. Material and methods: Exp.1. Ten-week-old female A/J mice were divided into 3 groups, and group 1 was given intraperitoneal injections of STZ (50mg/kg bw.) for 4 consecutive days. Group 2 was given a single i.p. injection of STZ. Group 3 was served as an untreated control. Mice in groups 1 and 3 were sacrificed every 4 weeks, and group 2 was terminated 16 weeks after the treatment to determine the incidence and multiplicity of lung tumor. Exp.2. Ten-week-old female A/J mice were randamized into 3 groups, and group 1 was initiated with a single i.p. injection of STZ (50mg/kg bw.). Group 2 received a single i.p. injection of MNU (20mg/kg bw.; equivalent molar to 50mg/kg bw. STZ). Mice in group 3 was given an equal volume of citrate buffer. Mice were sacrificed to determine the incidence and multiplicity of lung tumors at weeks 16. Results: Exp.1. After the STZ treatment, blood glucose and serum HbA1c level of group 1 were significantly lager than those of groups 2 and 3. Incidence of lung proliferative lesions in group 1 was 100% at the 8, 12, and 16 weeks. Multiplicity and tumor size of group 1 were increased according to the time course. All mice in group 2 caused lung tumors without suffering diabetes. In STZ-induced tumors, we found no K- ras  gene codon 12 and/or 13 mutations. Exp.2. Incidence and multiplicity of lung tumor in Group 1 were significantly greater than those in group 2. Toxicities of liver, kidney, and pancreas were not observed in all groups. Conclusion: STZ is a selective lung carcinogen in A/J mice, and organ toxicities were not seen in dosage of 50mg/kg. This model is applicable to a short-term pulmonary tumor study and research for modulation effect of lung tumor by diabetes.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2376.
Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality
Authors: JoAnn E. Manson, Aaron K. Aragaki, Jacques E. Rossouw, Garnet L. Anderson, Ross L. Prentice, Andrea Z. LaCroix, Rowan T. Chlebowski, Barbara V. Howard, Cynthia A. Thomson, Karen L. Margolis, Cora E. Lewis, Marcia L. Stefanick, Rebecca D. Jackson, Karen C. Johnson, Lisa W. Martin, Sally A. Shumaker, Mark A. Espeland, Jean Wactawski-Wende
Journal: JAMA (2017)

Health outcomes from the Women's Health Initiative Estrogen Plus Progestin and Estrogen-Alone Trials have been reported, but previous publications have generally not focused on all-cause and cause-specific mortality.
THU0384 The effect and safety of yisaipu (YISAIPU) in the treatment of patients with nonradiographic axial spondyloarthritis in china
Authors: M Zhao, G Shi, Y Tao, X Wang, S Cao, Z Lin, Z Liao, Q Kong, J Gu
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Axial spondyloarthritis (axSpA) is a chronic inflammatory disease, which includes AS and nr-axSpA. Anti-TNF-α agents, such as Yisaipu (Yisaipu) are frequently used in nr-axSpA patients in China, but the related data is limited. <h3>Objectives</h3> The aim of this research is to assess the efficacy and safety of Yisaipu in the treatment of patients with nr-axSpA in China. <h3>Methods</h3> The inclusion of study population consisted of 150 patients who met the ASAS criteria for axial SpA but not the modified New York radiographic criteria for AS, had a score of ≥4 on the BASDAI or a score of ≥2.1 on the ASDAS-CRP and had been treated unsuccessfully with ≥1 NSAIDs for 4-week. Patients were assigned to receive Yisaipu (made in China) 50 mg/week and continued background NSAID treatment for 24 weeks (open-label study). At week 24, the primary efficacy end point was the improvement of ASDAS-CRP. Secondary end points included ASAS 20, ASAS 40, ASAS 5/6, ASAS partial remission and BASDAI. Safety was evaluated during scheduled visits. <h3>Results</h3> 123 patients with active nr-axSpA were enrolled between April 19, 2014, and July 10, 2015. The mean age of the 123 nr-SpA patients was (25.3±5.9) years. The ASDAS-CRP and BASDAI decrease from 2.7±0.9 to 0.7±0.4, from 4.5±1.5 to 0.9±0.8, respectively between weeks 0 and 24. The patients achieved the ASDAS-CRP&lt;2.1 was 96.7%. ASDAS-CRP major and important improvement were achieved by 41.4%, 79.8%, respectively at weeks 24. ASAS 20, ASAS 40, ASAS5/6 and ASAS partial remission were achieved by 75.0%, 54.8%, 64.5%, 89.3%, respectively at weeks 24. Yisaipu-treatment was associated with statistically significant improvements in all parameters, including BASFI, BASMI, PGA, PhGA, ESR and CRP concentrations. Most adverse events in the open-label phase were mild or moderate in severity. <h3>Conclusions</h3> Yisaipu was effective and well-tolerated during the 24-week study period and was associated with a significant improvement in the signs and symptoms of active nr-axSpA. <h3>Disclosure of Interest</h3> None declared
SAT0553 Detection of serum level changes of matrix metalloprotienase-13 and inter leukin-1 beta during remission and flare-ups of primary osteoarthritis of the knees
Authors: Y Hussein Gazar, H Bassiouni
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> The diagnosis of osteoarthritis is currently based on radiographic criteria (eg, joint space width) and clinical symptoms (eg, pain and loss of function). The evaluation of new disease-modifying osteoarthritis drugs (DMOADs) is performed on the same basis, since the regulatory bodies currently require evidence for an impact on radiographic joint space narrowing (JSN) and an impact on symptoms However, the limitations of radiography have led to research into alternative parameters for monitoring osteoarthritis that could serve as biomarkers in drug development. <h3>Objectives</h3> Detection the serum level of MMP-13 and IL-1 β In OA of the knee during remission and exacerbation and if these Biomarkers can be validated as gold biomarkers in assessing OA progression and drug development in OA treatment. <h3>Methods</h3> This study was performed on 60 patients with knee osteoarthritis, 18 males (30%) and 42 females (70%), all diagnosed as osteoarthritis of one or both knees. Their ages ranged from (40 -65) years. The duration of their disease ranged from one to 15years. The control groups were 8 males (32%) and 17 females (68%). their ages ranged from (40–65) years. The patients were allowed to continue on the medications that they have pro inflammatory cytokines (IL-1β) and degradative enzymes (MMP-13) are measured. Clinical assessing for pain using visual analogue scale (0–10) Assessing for pain, stiffness and physical functions by:(A) the WOMAC osteoarthritis index(B) Lequesne9s algo functional index Asssesing the flare-ups using Knee Osteoarthritis Flare Ups Score (KOFUS). <h3>Results</h3> Patients who had 3 flare-ups (during one year follow up) showed the statistically significantly highest mean IL-1β &amp; MMP13 level. There was no statistically significant difference between patients with no flare-up, 1 flare-up and 2 flare-ups; all showed statistically significantly lower mean levels. There was a statistically significant positive (direct) correlation between IL-1β, disease duration, KL, VAS, stiffness score, pain score, functional score, WOMAC and KOFUS. An increase in all these variables is associated with an increase in IL-1β &amp; MMP13. <h3>Conclusions</h3> There is a potential role for IL1 beta and MMP 13 biomarkers in assessing the development in osteoarthritis. IL 1 β and MMP 13 were founded to be correlated positively in patients with knee OA this correlation sounded right as the expression of MMP 13 depends on the level of IL1 β. Although all medications groups failed to lower the level of IL 1 β and MMP 13,yet there was a numerical difference in favor of Diacerine and NSAID. patients on both Diacerine and NSAID had the lowerest rate of flare ups It is recommended that the early measurement of biomarkers may detect cases to progress and thus stronger treatment may be given for these groups. <h3>Disclosure of Interest</h3> None declared
Abstract 198: Aberrant Endothelial-myocardial Crosstalk Causes Hypertrophy in Noonan Syndrome With Multiple Lentigines
Authors: Jessica Lauriol, Janel R Cabrera, Gabriel C Segarra, Meaghan E Flessa, Lauren E Miller, Roderick Bronson, Kyu-Ho Lee, Maria I Kontaridis
Journal: Circulation Research (2015)

Congenital heart disease (CHD) is the most common birth defect worldwide; however, underlying mechanisms remain unknown. Loss-of-function mutations in PTPN11, the gene encoding the protein tyrosine phosphatase SHP2, are implicated in CHD and cause Noonan Syndrome with Multiple Lentigines (NSML). NSML presents with multiple cardiac defects, including hypertrophy. Here, we found that the NSML-associated adult-onset cardiac hypertrophy stems from aberrant signaling originating from developing endocardium. Embryonic NSML hearts showed diminished trabeculation and valvular hyperplasia, defects recapitulated in endocardial-, but not myocardial- or neural crest-, specific NSML mice. NSML hearts also developed ventricular septal defects, a phenotype reproduced only in myocardial-specific NSML hearts, suggesting NSML mutations have both cell autonomous and non-autonomous functions in cardiac development. Importantly, endocardial-specific expression of NSML was sufficient to induce adult-onset cardiac hypertrophy. Mechanistically, we observed aberrant AKT activity in NSML embryos, with decreased downstream FOXP1/FGF and NOTCH1/EPHB2 signaling, two pathways necessary for reciprocal crosstalk between developing endocardium and myocardium. Taken together, our data provide the first functional and disease-based evidence to suggest that critical mechanisms exist to control endocardial-myocardial crosstalk, the aberrant regulation of which may lead to CHD and adult-onset cardiac disease.
THU0252 Nailfold capillaroscopy in systemic lupus erythematosus: a systematic review and critical appraisal
Authors: S Wijnant, F Ingegnoli, K Melsens, K Thevissen, F De Keyser, S Decuman, E Deschepper, O Distler, U Müller-Ladner, Y Piette, V Riccieri, N Ughi, E Vandecasteele, M Cutolo, V Smith
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a rheumatic disease with common vascular involvement. Nailfold capillaroscopic changes have been described in SLE. Although, until today there is no clear role yet for capillaroscopy in classifying or staging the disease. <h3>Objectives</h3> To systematically review and critically appraise the literature on capillaroscopic changes described in SLE. <h3>Methods</h3> A sensitive search, on behalf of the EULAR study group on microcirculation in Rheumatic Diseases, was developed in Web Of Science, PubMed and Embase to identify all original research studies in which SLE patients had capillaroscopy. Two reviewers identified titles, abstracts and full texts. Exclusion criteria were: ACR criteria for SLE were not met, less than 5 patients were included in the study, there was no information on capillaroscopy in SLE, no original research or non-English language. All included articles underwent quality appraisal. Results were summarised according to density, dimensions, morphology, haemorrhages, semi quantitative assessment, qualitative assessment (see table) and correlation of capillaroscopic changes with clinical and laboratory parameters. <h3>Results</h3> From 172 articles captured, 36 articles were included in this review. The following capillaroscopic parameters were significantly more prevalent in SLE patients compared to healthy controls (see table): tortuous capillaries, abnormal morphology, haemorrhages, nailfold capillaroscopic score, "non-specific patterns" and "scleroderma like pattern". Hairpin shaped capillaries were significantly more prevalent in healthy controls compared to SLE patients. For clinical and laboratory parameters, Raynaud9s phenomenon (RP), gangrene and 24 hours proteinuria were significantly correlated with capillaroscopic changes. <h3>Conclusions</h3> This first systematic review on capillaroscopy in SLE attests conclusive significant differences in morphology, haemorrhages, semi quantitative assessment, qualitative assessment and some clinical and laboratory parameters. Further large scale research is ongoing through the EULAR study group on microcirculation in Rheumatic Diseases to further define its role. <h3>Disclosure of Interest</h3> None declared
Tethering IL2 to Its Receptor IL2Rβ Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells
Authors: Youssef Jounaidi, Joseph F. Cotten, Keith W. Miller, Stuart A. Forman
Journal: Cancer Research (2017)

Abstract IL2 is an immunostimulatory cytokine for key immune cells including T cells and natural killer (NK) cells. Systemic IL2 supplementation could enhance NK-mediated immunity in a variety of diseases ranging from neoplasms to viral infection. However, its systemic use is restricted by its serious side effects and limited efficacy due to activation of T regulatory cells (Tregs). IL2 signaling is mediated through interactions with a multi-subunit receptor complex containing IL2Rα, IL2Rβ, and IL2Rγ. Adult natural killer (NK) cells express only IL2Rβ and IL2Rγ subunits and are therefore relatively insensitive to IL2. To overcome these limitations, we created a novel chimeric IL2-IL2Rβ fusion protein of IL2 and its receptor IL2Rβ joined via a peptide linker (CIRB). NK92 cells expressing CIRB (NK92CIRB) were highly activated and expanded indefinitely without exogenous IL2. When compared with an IL2-secreting NK92 cell line, NK92CIRB were more activated, cytotoxic, and resistant to growth inhibition. Direct contact with cancer cells enhanced the cytotoxic character of NK92CIRB cells, which displayed superior in vivo antitumor effects in mice. Overall, our results showed how tethering IL2 to its receptor IL2Rβ eliminates the need for IL2Rα and IL2Rβ, offering a new tool to selectively activate and empower immune therapy. Cancer Res; 77(21); 5938–51. ©2017 AACR.
The altered PD-1/PD-L1 pathway delivers the ‘one-two punch’ effects to promote the Treg/Th17 imbalance in pre-eclampsia
Authors: Yonghong Zhang, Zhaozhao Liu, Mei Tian, Xiaohui Hu, Liling Wang, Jinlu Ji, Aihua Liao
Journal: Cellular and Molecular Immunology (2017)
Behavior of Thymus Tissue Transplanted to a Skin Wound
Authors: Thelma B. Dunn
Journal: JNCI Journal of the National Cancer Institute (1945)

Journal Article Behavior of Thymus Tissue Transplanted to a Skin Wound Get access Thelma B. Dunn Thelma B. Dunn research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 5, Issue 4, February 1945, Pages 285–288, https://doi.org/10.1093/jnci/5.4.285 Published: 01 February 1945
THU0159 Rheumatoid arthritis may not influence eating behaviours characteristics
Authors: N Bulut, ME Tezcan
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Patients with rheumatoid arthritis (RA) have an increased risk of obesity and cardiovascular disease compared with the general population (1). Eating behaviours may play an important role in obesity and cardiovascular disease. <h3>Objectives</h3> We hypothesised that RA patients have impaired eating behaviours that may have a role in obesity. For evaluating this hypothesis, we compared eating behaviours of patients with RA, osteoarthritis (OA) and healthy controls. <h3>Methods</h3> One hundred and fifty-seven RA patients (M/F: 23/134) who fulfilled the 2010 American College of Rheumatology (ACR) RA classification criteria, 31 hand OA patients (M/F: 1/30) who fulfilled 1990 ACR hand OA criteria and 60 healthy controls (M/F: 9/51) were enrolled to the study who applied to Kartal Dr. Lutfi Kirdar Training and Research Hospital Rheumatology outpatient clinic. Eating behaviours was assessed by the Three-Factor Eating Questionnaire (TFEQ).Demographic data, smoking status, co-morbidities, anthropometric measurements, VAS pain score were analyzed. <h3>Results</h3> There were no differences between three groups in demographic features and anthropometric measurements (table1). Moreover, there were no differences between three groups in cognitive restraint and emotional eating scores.Although,healthy controls had significantly higher uncontrolled eating scores than the RA group (p&lt;0.05), uncontrolled eating scores of all three groups were lower than Turkish people average scores (2) (table2). <h3>Conclusions</h3> This was the first study using the TFEQ in patients with RA. In our study, we found that disease features of RA may had no effect on eating behaviors. <h3>References</h3> Kitas GD, Erb N. Tackling ischemic heart disease in rheumatoid arthritis. Rheumatology (Oxford). 2003;42(5):607–13. Kıraç D, Kaspar EÇ, Avcılar T, Çakır ÖK, Ulucan K, Kurtel H, ve ark. Obeziteyle ilişkili beslenme alışkanlıklarının araştırılmasında yeni bir yöntem "Üç Faktörlü Beslenme Anketi". MÜSBED. 2015;5(3):162–9. <h3>Acknowledgements</h3> None. <h3>Disclosure of Interest</h3> None declared
Abstract 286: Role of ATP-sensitive Potassium Channel Openers in Prevention of Atrial Fibrillation
Authors: Cevher Ozcan, Zhenping Li
Journal: Circulation Research (2016)

Introduction: The ATP-sensitive potassium (K ATP ) channel dysfunction causes susceptibility to adrenergic atrial fibrillation (AF). However, the therapeutic efficacy of K ATP activation in primary prevention of AF is not known. We hypothesized that K ATP channel opening drugs prevent AF with effective metabolic and mechanosensitive gating of K ATP channels and preserving electro-anatomical stability in atria by regulating oxidative and metabolic states. Methods: This hypothesis was tested in a novel mouse model of AF, cardiac specific LKB1 knockout (KO) mice. Male and female LKB1 KO mice were treated with K ATP channel openers, nicorandil (15 mg/kg/day) and diazoxide (10 mg/kg/day). Control group included untreated littermates of the study group. Incidence of AF, structural and electrophysiological property of atria and sex-based differences were analyzed at the 3 months of age in all groups. Results: The incidence of spontaneous AF was significant reduced in LKB1 KO male mice with nicorandil (0%, n=5) and diazoxide (33%, n=6) treatment compare to untreated mice (84.6%, n=13) (p&lt;0.05). The treatment was also effective in female LKB1 KO mice as AF occurred in 37.5% of nicorandil (n=8) and 40% of diazoxide (n=5) (p&lt;0.05) treated mice as oppose to 71% of untreated mice (n=24). The K ATP openers, particularly nicorandil, were more effective in male mice preventing AF. There was 100% risk reduction with nicorandil in male mice compare to 39% with diazoxide. Nicorandil demonstrated 52% risk reduction in female mice while it was 56% with diazoxide treatment. Prevention of AF was associated with preservation of atrial structural and electrical property including size, heart rate and conduction intervals. Biatrial enlargement was significantly prevented by K ATP openers compare to untreated mice. Incidence of AF was significantly higher in male mice than female with or without treatment. Conclusions: Activation of sarcolemmal and mitochondrial K ATP channels prevents AF by preserving electro-anatomical property of atria and decreasing susceptibility to AF. Metabolic regulation of K ATP is essential in AF. Thus, the K ATP openers are novel upstream therapy for primary prevention of AF in vulnerable population.
Oral surgeon whose misconduct was “serious, persistent, and shocking” is struck off
Authors: Clare Dyer
Journal: BMJ (2017)

A consultant maxillofacial surgeon who harmed patients by carrying out inappropriate surgery—including using an experimental material to rebuild bone—without obtaining informed consent has been struck off the UK medical register.

Roger Bainton was accused of inappropriately treating 11 patients and failing to properly inform them of the risks and benefits of proposed procedures.

In 2000 Bainton was reprimanded by a General Medical Council professional conduct committee that found him guilty of serious misconduct in the death of 33 year old Aberdeen patient Iain Duncan. Duncan had suffered a heart attack when Bainton left him …
AB0723 Technical aids agreed among specialists for the management of comorbidity in patients with axial spondyloarthritis: the gecoax project
Authors: C González, R Curbelo, JC Torre-Alonso, E Collantes, S Castañeda, MV Hernández, A Urruticoechea-Arana, JC Nieto, J García, MΆ Abad, J Ramírez, C Suárez, R Dalmau, MD Martín-Arranz, L Leόn, JC Hermosa, JC Obaya, T Otόn, L Carmona
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> The management of comorbidity in patients with axial spondyloarthritis (Ax-SpA) needs improvement; the implementation of clinical practice guidelines is still deficient and heterogeneous. <h3>Objectives</h3> To prioritise comorbidities in Ax-SpA and to elaborate practical aids for their identification and follow-up. <h3>Methods</h3> A multidisciplinary panel [10 rheumatologists (6 experts in Ax-SpA), 2 family doctors, 1 internist, 1 cardiologist, 1 gastroenterologist, 1 psychologist and 3 methodologists] prioritised, in a discussion group, a list of comorbidities based on frequency and impact. Each comorbidity was discussed largely and systematic reviews were performed to support or discard items. In a second meeting, items to be included were presented, discussed, and those with lower priority disregarded. <h3>Results</h3> The panel produced a checklist for health professionals and another for patients. Each item is supported by arguments and references. Table 1 shows, schematically, the items included in the checklists. <h3>Conclusions</h3> These checklists are intended to facilitate the systematic evaluation of co-morbidity associated with Ax-SpA, thus allowing an earlier detection and better control and management of these patients by the rheumatologist. <h3>Acknowledgements</h3> This project was funded by Merck Sharp &amp; Dohme Spain. Merck Sharp &amp; Dohme had no influence on either the development of the project or the final content of the abstract. <h3>Disclosure of Interest</h3> None declared