tbuckley/cabot-search huggingface dataset:
Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies
Authors: Felipe B. Schuch, Davy Vancampfort, Joseph Firth, Simon Rosenbaum, Philip B. Ward, Edson S. Silva, Mats Hallgren, Antonio Ponce De Leon, Andrea L. Dunn, Andrea C. Deslandes, Marcelo P. Fleck, Andre F. Carvalho, Brendon Stubbs
Journal: American Journal of Psychiatry (2018)

The authors examined the prospective relationship between physical activity and incident depression and explored potential moderators.Prospective cohort studies evaluating incident depression were searched from database inception through Oct. 18, 2017, on PubMed, PsycINFO, Embase, and SPORTDiscus. Demographic and clinical data, data on physical activity and depression assessments, and odds ratios, relative risks, and hazard ratios with 95% confidence intervals were extracted. Random-effects meta-analyses were conducted, and the potential sources of heterogeneity were explored. Methodological quality was assessed using the Newcastle-Ottawa Scale.A total of 49 unique prospective studies (N=266,939; median proportion of males across studies, 47%) were followed up for 1,837,794 person-years. Compared with people with low levels of physical activity, those with high levels had lower odds of developing depression (adjusted odds ratio=0.83, 95% CI=0.79, 0.88; I2=0.00). Furthermore, physical activity had a protective effect against the emergence of depression in youths (adjusted odds ratio=0.90, 95% CI=0.83, 0.98), in adults (adjusted odds ratio=0.78, 95% CI=0.70, 0.87), and in elderly persons (adjusted odds ratio=0.79, 95% CI=0.72, 0.86). Protective effects against depression were found across geographical regions, with adjusted odds ratios ranging from 0.65 to 0.84 in Asia, Europe, North America, and Oceania, and against increased incidence of positive screen for depressive symptoms (adjusted odds ratio=0.84, 95% CI=0.79, 0.89) or major depression diagnosis (adjusted odds ratio=0.86, 95% CI=0.75, 0.98). No moderators were identified. Results were consistent for unadjusted odds ratios and for adjusted and unadjusted relative risks/hazard ratios. Overall study quality was moderate to high (Newcastle-Ottawa Scale score, 6.3). Although significant publication bias was found, adjusting for this did not change the magnitude of the associations.Available evidence supports the notion that physical activity can confer protection against the emergence of depression regardless of age and geographical region.
Jump load: capturing the next great injury analytic
Authors: Layla R Moran, Eric J Hegedus, Chris M Bleakley, Jeffrey B Taylor
Journal: British Journal of Sports Medicine (2018)

Monitoring athletes is fundamental to exploring the relationship between load and risk of injury. Traditionally, load monitoring in sport was limited to single metrics of external load such as running mileage, but this has recently advanced to quantification of multiple internal (eg, heart rate and rating of perceived exertion) and external loading variables (eg, running speed, watts produced, on-field impacts and number of accelerations). A 2016 consensus statement by the International Olympic Committee on load in sport and risk of injury highlighted that sport-specific guidelines for load management were lacking; empirical data must develop beyond a few select sports and populations.1 Forthcoming research must incorporate load measures relevant and specific to sports of interest.

Popular multidirectional sports such as volleyball or basketball have significant jumping demands. Although we know the distinct movement patterns that can cause injuries during landing (ie, dynamic lower extremity valgus and stiff-legged landings),2 jumping and landing loads have been vastly understudied and we do not know when these movement strategies might transition from occasional aberrant mechanics to injurious …
Discovery of Inhibitors of NLRP3 inflammasome assembly for the treatment of NASH and liver fibrosis
Authors: J. Veal, C. Mcbride, M. Lazic, D. Povero, G. Ambrus, A. Santini, R. Stansfield, L. Trzoss, C.D. Johnson, J. Stafford, A. Feldstein
Journal: Journal of Hepatology (2018)
Admitting What We Do Not Know in Rheumatologic Disease—The First Step Toward Learning More
Authors: Liron Caplan, John FitzGerald
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Antiviral properties and liver specific delivery of a TLR1/2 ligand in HBV-infected in vitro and in vivo models
Authors: J. Lucifora, F. Fusil, L. Myriam, P. Capucine, M. Maud, D. Laura, A. Ludovic, B. Maud, F.-D. Suzanne, R. Michel, S. Daffis, S. Fletcher, F. Zoulim, A. Salvetti, F.L. Cosset, V. Bernard, D. Durantel
Journal: Journal of Hepatology (2018)
Lymphomas incidence in HIV/HCV coinfected versus HIV monoinfected patients over twenty-one years of follow up (1993–2014)
Authors: Á.M. de Cea, I. Rodríguez-Osorio, H. Meijide, J. Balinas, J.D. Pedreira, M. de Los Ángeles Castro Iglesias
Journal: Journal of Hepatology (2018)
Pharmacokinetics and pharmacodynamics of seladelpar, a potent and selective PPAR-delta, in patients with primary biliary cholangitis
Authors: P. Boudes, G. Michael, C. Bowlus, G. Hirschfield, D. Jones, J. Odin, D. Sheridan, N. Gitlin, S. Harrison, T. Hassanein, C. Levy, M. Shiffman, D. Thorburn, P.J. Thuluvath, J. Vierling, Y.-J. Choi, M. Varga, A. (Sasha) Steinberg, C. Mcwherter, R. Martin
Journal: Journal of Hepatology (2018)
The microbiome and autoimmunity: a paradigm from the gut–liver axis
Authors: Bo Li, Carlo Selmi, Ruqi Tang, M E Gershwin, Xiong Ma
Journal: Cellular and Molecular Immunology (2018)

Microbial cells significantly outnumber human cells in the body, and the microbial flora at mucosal sites are shaped by environmental factors and, less intuitively, act on host immune responses, as demonstrated by experimental data in germ-free and gnotobiotic studies. Our understanding of this link stems from the established connection between infectious bacteria and immune tolerance breakdown, as observed in rheumatic fever triggered by Streptococci via molecular mimicry, epitope spread and bystander effects. The availability of high-throughput techniques has significantly advanced our capacity to sequence the microbiome and demonstrated variable degrees of dysbiosis in numerous autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, multiple sclerosis and autoimmune liver disease. It remains unknown whether the observed differences are related to the disease pathogenesis or follow the therapeutic and inflammatory changes and are thus mere epiphenomena. In fact, there are only limited data on the molecular mechanisms linking the microbiota to autoimmunity, and microbial therapeutics is being investigated to prevent or halt autoimmune diseases. As a putative mechanism, it is of particular interest that the apoptosis of intestinal epithelial cells in response to microbial stimuli enables the presentation of self-antigens, giving rise to the differentiation of autoreactive Th17 cells and other T helper cells. This comprehensive review will illustrate the data demonstrating the crosstalk between intestinal microbiome and host innate and adaptive immunity, with an emphasis on how dysbiosis may influence systemic autoimmunity. In particular, a gut–liver axis involving the intestinal microbiome and hepatic autoimmunity is elucidated as a paradigm, considering its anatomic and physiological connections.
National outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to mixed salad leaves, United Kingdom, 2016
Authors: Maya Gobin, Jeremy Hawker, Paul Cleary, Thomas Inns, Daniel Gardiner, Amy Mikhail, Jacquelyn McCormick, Richard Elson, Derren Ready, Tim Dallman, Iain Roddick, Ian Hall, Caroline Willis, Paul Crook, Gauri Godbole, Drazenka Tubin-Delic, Isabel Oliver
Journal: Eurosurveillance (2018)

We investigated a large outbreak of Escherichia coli O157 in the United Kingdom (UK) with 165 cases between 31 May and 29 July 2016. No linked cases were reported in other countries. Cases were predominately female (n = 128) and adult (n = 150), 66 attended hospital and nine had features of haemorrhagic uraemic syndrome. A series of epidemiological studies (case–control, case–case, ingredients-based and venue-based studies) and supply chain investigations implicated mixed salad leaves from Supplier A as the likely outbreak vehicle. Whole genome sequencing (WGS) indicated a link with strains from the Mediterranean and informed the outbreak control team to request that Supplier A cease distributing salad leaves imported from Italy. Microbiological tests of samples of salad leaves from Supplier A were negative. We were unable to confirm the source of contamination or the contaminated constituent leaf although our evidence pointed to red batavia received from Italy as the most likely vehicle. Variations in Shiga toxin-producing E. coli surveillance and diagnosis may have prevented detection of cases outside the UK and highlights a need for greater standardisation. WGS was useful in targeting investigations, but greater coverage across Europe is needed to maximise its potential.
CRISPR interference-based specific and efficient gene inactivation in the brain
Authors: Yi Zheng, Wei Shen, Jian Zhang, Bo Yang, Yao-Nan Liu, Huihui Qi, Xia Yu, Si-Yao Lu, Yun Chen, Yu-Zhou Xu, Yun Li, Fred H. Gage, Shuangli Mi, Jun Yao
Journal: Nature Neuroscience (2018)
Metabolically Healthy Obesity, Transition to Metabolic Syndrome, and Cardiovascular Risk
Authors: Morgana Mongraw-Chaffin, Meredith C. Foster, Cheryl A.M. Anderson, Gregory L. Burke, Nowreen Haq, Rita R. Kalyani, Pamela Ouyang, Christopher T. Sibley, Russell Tracy, Mark Woodward, Dhananjay Vaidya
Journal: Journal of the American College of Cardiology (2018)
NGM282, an engineered analogue of FGF19, significantly improves markers of bile acid synthesis, hepatic injury and fibrosis in PSC patients: Results of a phase 2, multicenter, randomized, doubleblind, placebo-controlled trial
Authors: G. Hirschfield, O. Chazouillères, J. Ph Drenth, D. Thorburn, S. Harrison, C. Landis, M.J. Mayo, A. Muir, J.F. Trotter, M. Karsdal, M. Jaros, L. Ling, K.H. Kim, S. Rossi, R.M. Somaratne, A. Depaoli, U. Beuers
Journal: Journal of Hepatology (2018)
Survival outcomes in HER2-positive invasive lobular breast carcinoma.
Authors: Carlos Hernando Barcenas, Kenneth R. Hess, Yann Delpech, Lajos Pusztai, Gabriel N. Hortobagyi, Sharon Hermes Giordano, Francisco J. Esteva
Journal: Journal of Clinical Oncology (2012)

612 Background: HER2-positive (HER2+) invasive lobular breast carcinoma (ILC) is a rare entity and survival outcomes are not well characterized. Methods: We retrospectively searched for breast cancer patients treated at MD Anderson Cancer Center between 1992 and 2010 with a diagnosis of early stage (I-III) HER2+ILC or with HER2+ invasive mixed ductal/lobular carcinoma (MIX). With the purpose of comparing survival outcomes, we looked for patients with a diagnosis of HER2-negative [HER2(-)] ILC, HER2(-)MIX, and HER2+ invasive ductal carcinomas (IDC). We obtained data on demographics, estrogen (ER) and progesterone (PR) receptor status, tumor grade, chemotherapy received and survival status. A multivariate analysis using a Cox proportional hazards regression was performed to compare disease-free survival (DFS) and overall survival (OS) between the following groups: 1) HER2+ILC vs. HER2(-)ILC; 2) HER2+MIX vs. HER2(-)MIX; 3) HER2+ILC vs. HER2+MIX; 4) HER2+ILC vs. HER2+IDC; 5) HER2+MIX vs. HER2+IDC. Results: The number of patients identified for each group was: HER2+ILC (N= 67), HER2(-)ILC (N= 1260), HER2+MIX (N= 92), HER2(-)MIX (N= 932), HER2+IDC (N= 3080). Specifically for both the HER2+ILC and HER2+MIX groups, 24% patients were stage I, 43% stage II and 33% stage III. The median age at diagnosis was 53 years (y) in HER2+ILC, and 49 y in HER2+MIX. The ER/PR were both negative in 16% of HER2+ILC patients, and in 25% of HER2+MIX. While 80% of patients in these two groups received chemotherapy, 36% of HER2+ILC patients received trastuzumab compared to 50% of HER2+MIX. The median follow up was 60 months in the HER2+ILC group and 53 months in the HER2+MIX group. DFS and OS were not statistically different between all groups compared. However, the subgroup of ER/PR negative HER2+MIX patients had a better OS compared to ER/PR/HER2 negative (triple negative) MIX patients (Hazard ratio = 0.4, 0.2 – 0.9, p= 0.026). Conclusions: HER2+ILC and HER2+MIX are rare clinical entities and their survival outcomes may not differ from the more common HER2(-)ILC, HER2(-)MIX and HER2+IDC. ER/PR negative HER2+MIX may have an OS advantage over triple negative MIX tumors.
239Single-cell sequencing of the healthy and diseased heart reveals Ckap4 as a new modulator of fibroblasts activation
Authors: M M Gladka, B Molenaar, H De Ruiter, D Versteeg, H Tsui, GPA Lacraz, S Van Der Elst, MMH Huibers, A Van Oudenaarden, E Van Rooij
Journal: Cardiovascular Research (2018)
P567Effect of AIMp1/p43 protein on heart function in hypertension
Authors: N A Dorofeyeva, O Y Tsuvariev, A I Kornelyuk, V F Sagach
Journal: Cardiovascular Research (2018)

phosphorylation on the inhibitory Ser377 in response to inflammatory stimuli.Endothelial cell-specific CSE deletion reduced H2S bioavailability by 70%, increased 5-fold L-cystathionine circulating levels and resulted in endothelial cell dysfunction in murine aortas, elevated monocyte adhesion and accelerated atherosclerosis.Overall, reduced H2S bioavailability in the murine and human vascular wall resulted in the loss of sulfhydration of the RNA binding protein HuR, which potentiated the homodimerization of HuR and its capacity to bind to the 3' UTR of its targets CD62E and CTSS.Conclusion: H2S produced by CSE, constitutively S-sulfhydrates HuR to inhibit its activity and limit the expression of its pro-atherogenic protein targets.L-cystathionine may serve as a biomarker of endothelial cell dysfunction and a prognostic marker of CSE activity and atherosclerosis development. P565Vascular endothelial cells exposed to oxidized HDL increases LOX-1 destination at the plasma membrane through a mechanism involving ROS/NOX/NF-kB/LOX-1 pathway
High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML
Authors: Sanjay S. Patel, Frank C. Kuo, Christopher J. Gibson, David P. Steensma, Robert J. Soiffer, Edwin P. Alyea, Yi-Bin A. Chen, Amir T. Fathi, Timothy A. Graubert, Andrew M. Brunner, Martha Wadleigh, Richard M. Stone, Daniel J. DeAngelo, Valentina Nardi, Robert P. Hasserjian, Olga K. Weinberg
Journal: Blood (2018)
Changes in serum levels of the novel mac-2 binding protein glycosylation isomer and risk of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleos(t)ide analogues
Authors: Y.-C. Hsu, T. Jun, M.-L. Yeh, Y.-T. Huang, M.-L. Yu, M. Nguyen, Y. Tanaka
Journal: Journal of Hepatology (2018)
P357Nrf2 sequesters Keap1 preventing endothelial dysfunction
Authors: A Kopacz, D Kloska, D Cysewski, J Dulak, A Jozkowicz, A Grochot-Przeczek
Journal: Cardiovascular Research (2018)

JNK were not causally linked to the upregulation of Flt1 and Angpt2.We demonstrated that PKCinduced transcription of Angpt2 and Flt1 involved the transcription factor Ets1, as a combined knockdown of Fzd5 and Ets1 completely blocked the enhanced Angpt2 expression, and reduced the upregulation of Flt1 by almost 50% (both n¼4, P<0.05).In addition, an intervention with knockdown of Ets1 on top of the Fzd5 knockdown also partially rescued the poor angiogenic phenotype observed in the 3D co-culture model (n¼6, P<0.05), indicating that this transcription factor was critically involved in suppressing angiogenesis in absence of Fzd5.Conclusions: The current study provides evidence for a pro-angiogenic role of Fzd5, which was shown to be involved in endothelial tubule formation, cell cycle progression and migration, and does so by repression of PKC/Ets1-mediated transcription of Flt1 and Angpt2.
Three Rotavirus Outbreaks in the Postvaccine Era — California, 2017
Authors: Rachel M. Burke, Jacqueline E. Tate, Nora Barin, Carly Bock, Michael D. Bowen, David Chang, Rashi Gautam, George Han, John Holguin, Thalia Huynh, Chao-Yang Pan, Rebecca Quenelle, Catherine Sallenave, Cindy Torres, Debra Wadford, Umesh Parashar
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Before the introduction of rotavirus vaccine in 2006, rotavirus was the most common cause of severe diarrhea among U.S. children (1).Currently, two rotavirus vaccines are licensed for use in the United States, both of which have demonstrated good field effectiveness (78%-89%) against moderate to severe rotavirus illness (2), and the use of these vaccines has substantially reduced the prevalence of rotavirus in the United States (3).However, the most recent national vaccine coverage estimates indicate lower full rotavirus vaccine-series completion (73%) compared with receipt of at least 3 doses of vaccines containing diphtheria, tetanus, and pertussis antigens (95%), given on a similar schedule to rotavirus vaccines (4).In the postvaccine era in the United States, rotavirus activity persists in a biennial pattern (3).This report describes three rotavirus outbreaks that occurred in California in 2017.One death was reported; however, the majority of cases were associated with mild to moderate illness, and illness occurred across the age spectrum as well as among vaccinated children.Rotavirus vaccines are designed to mimic the protective effects of natural infection and are most effective against severe rotavirus illness (2).Even in populations with high vaccination coverage, some rotavirus infections and mild to moderate illnesses will occur.Rotavirus vaccination should continue to be emphasized as the best means of reducing disease prevalence in the United States.
CRISPR/Cas9 for cancer research and therapy
Authors: Tianzuo Zhan, Niklas Rindtorff, Johannes Betge, Matthias P. Ebert, Michael Boutros
Journal: Seminars in Cancer Biology (2018)

CRISPR/Cas9 has become a powerful method for making changes to the genome of many organisms. First discovered in bacteria as part of an adaptive immune system, CRISPR/Cas9 and modified versions have found a widespread use to engineer genomes and to activate or to repress the expression of genes. As such, CRISPR/Cas9 promises to accelerate cancer research by providing an efficient technology to dissect mechanisms of tumorigenesis, identify targets for drug development, and possibly arm cells for cell-based therapies. Here, we review current applications of the CRISPR/Cas9 technology for cancer research and therapy. We describe novel Cas9 variants and how they are used in functional genomics to discover novel cancer-specific vulnerabilities. Furthermore, we highlight the impact of CRISPR/Cas9 in generating organoid and mouse models of cancer. Finally, we provide an overview of the first clinical trials that apply CRISPR/Cas9 as a therapeutic approach against cancer.
Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas
Authors: Christopher W. Mount, Robbie G. Majzner, Shree Sundaresh, Evan P. Arnold, Meena Kadapakkam, Samuel Haile, Louai Labanieh, Esther Hulleman, Pamelyn J. Woo, Skyler P. Rietberg, Hannes Vogel, Michelle Monje, Crystal L. Mackall
Journal: Nature Medicine (2018)
Novel link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD
Authors: C. Caussy, C. Hsu, L. Min-Tzu, L. Amy, R. Bettencourt, V. Ajmera, B. Shirin, J. Hooker, S. Ethan, L. Richards, N. Schork, B. Schnabl, B. David, C. Sirlin, C. Chi-Hua, R. Loomba
Journal: Journal of Hepatology (2018)
UK agrees deal to promote healthcare technologies in India
Authors: Sanjeet Bagcchi
Journal: BMJ (2018)

The UK and Indian governments have agreed a joint deal to expand research and roll out artificial intelligence and digital health technologies across India.

The UK government is reportedly investing £1m (€1.14m; $1.4m) in the project—which is expected to develop a business worth nearly £50m for the digital health industry in the UK—by enabling participation of British enterprises that deal with innovative healthcare technologies.

There are also plans to …
Glomerular filtration rate evaluation in patients with cirrhosis, which equation shall be used in clinical daily practice?
Authors: S. Monteiro, M. Bibi, R. Lucas, J. Gandara, V. Lopes, D. Valadares, S. Ferreira, C.S. Macedo, M.T. Gomes, C. Rosário, H.P. Miranda, F.G.C. Nery
Journal: Journal of Hepatology (2018)
Severe bleeding is a rare event in patients receiving lumen-apposing metal stents for the drainage of pancreatic fluid collections
Authors: Sebastian Zeissig, Stefan Sulk, Stefan Brueckner, Katja Matthes, Margarete Hohmann, Stephanie Reichel, Mark Ellrichmann, Alexander Arlt, Uwe Will, Jochen Hampe
Journal: Gut (2018)

Pancreatic fluid collections (PFCs) including pancreatic pseudocysts (PPCs) and walled-off necrosis (WON) frequently develop in the context of pancreatitis. Lumen-apposing self-expanding metal stents (LAMS) are increasingly used for the endoscopic management of infected and symptomatic PFCs since they facilitate direct endoscopic inspection and necrosectomy of WONs.1–3 However, two reports recently published in Gut 4 5 demonstrated high rates of haemorrhage associated with LAMS that were observed in up to 25% of patients and often occurred in a delayed manner with serious and fatal bleeding episodes reported. These data raised important concerns about the safety of LAMS and the optimal management of patients with infected or symptomatic PFCs.

As a limitation, the reports by Bang et al 4 and Stecher et al 5 were based on relatively small group sizes of 12 and 46 LAMS-treated patients, respectively. To investigate whether the reported safety signals are similarly observed in …
Risks and Benefits of Adjuvant Radiotherapy After Inguinal Lymphadenectomy in Node-positive Penile Cancer: A Systematic Review by the European Association of Urology Penile Cancer Guidelines Panel
Authors: Richard Robinson, Lorenzo Marconi, Ekelechi MacPepple, Oliver W. Hakenberg, Nick Watkin, Yuhong Yuan, Thomas Lam, Steven MacLennan, Temitope E. Adewuyi, Alberto Coscione, Suks S. Minhas, Eva M. Compérat, Andrea Necchi
Journal: European Urology (2018)
Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood
Authors: Brooke Tata, Nour El Houda Mimouni, Anne-Laure Barbotin, Samuel A. Malone, Anne Loyens, Pascal Pigny, Didier Dewailly, Sophie Catteau-Jonard, Inger Sundström-Poromaa, Terhi T. Piltonen, Federica Dal Bello, Claudio Medana, Vincent Prevot, Jerome Clasadonte, Paolo Giacobini
Journal: Nature Medicine (2018)