tbuckley/cabot-search huggingface dataset:
Rook's Textbook of Dermatology, 9th edn. ChristopherGriffiths, JonathanBarker, TanyaBleiker, RobertChalmers, DanielCreamer, eds. Publisher: Wiley-Blackwell, 2016; 4696 pp. ISBN: 978-1118441190. Price €654.49.
Authors: C. Paul
Journal: British Journal of Dermatology (2017)
Validation of the Baveno VI elastography criteria for the definition of compensated advanced chronic liver disease: an individual patient meta-analysis
Authors: E. Tsochatzis, J.B. Hiriart, M. Lupsor-Platon, F. Bronte, J. Boursier, F. Marra, A. Payance, E. Brodkin, L. Castera, G. Papatheodoridis, U. Arena, P. Cales, V. Calvaruso, V. de Ledinghen, M. Pinzani
Journal: Journal of Hepatology (2017)
Oxaliplatin-based neoadjuvant chemoradiation for locally advanced rectal cancer
Authors: S. S. Kazmi, M. Azfar, A. A. Syed, M. A. Yusuf
Journal: Journal of Clinical Oncology (2009)

e15102 Background: Preoperative chemoradiation improves local recurrence in patients with locally advanced rectal cancer 1 . The survival benefit of 5-FU based chemotherapy with radiation has been questioned 2 . Oxaliplatin based protocols have shown promise but the optimal regime remains to be defined 3,4 . We report our experience with addition of Oxaliplatin to neoadjuvant chemoradiation for rectal cancer. Methods: For this retrospective study, thirty-six consecutive patients referred for neoadjuvant chemoradiation for rectal cancer between May 2007 and March 2008 were identified. All patients had histologically proven adenocarcinoma, and were clinical stage T3/T4 or N+, except for one who was T2N0. Outcomes of interest were R0 resection rate and pathological complete response rate(pCR). Neoadjuvant treatment consisted of upto 4 cycles of CapOx(oxaliplatin 130 mg/m2, IV, D1, capecitabine (2,000 mg/m2/day, D1–14, q3 weeks), followed by capecitabine(1650mg/m2/day) with concurrent pelvic radiation(50.4Gy/28 fractions). Restaging to assess resectability was done at 4–6 weeks and definitive TME surgery was undertaken 6–8 weeks after end of chemoradiation Results: Thirty patients(oxaliplatin group) received at least 1 cycle of CapOx(range 1–8). Radical radiotherapy to 50.4Gy/28# was completed in 29/36 patients(81%). Surgical resection was undertaken in 24/36 patients(67%). Resection rate, R0 resection rate, pCR and local recurrence rate were 63%(19/30), 95%(18/19), 32%(6/19), and 5%(1/19) in the oxaliplatin group. In patients with low rectal cancer (0–5cm from anal verge), 16/26(62%) underwent resection. Sphincter sparing surgery was carried out in 7 patients, all of whom had received oxaliplatin, giving a sphincter sparing surgery rate of 64%(7/11) in the oxaliplatin group. Conclusions: Addition of oxaliplatin to neoadjuvant chemoradiation results in a significant number of patients achieving R0 resection, pCR and sphincter sparing surgery, compared to historical controls. No significant financial relationships to disclose.
Targeting the RON/MET/TAM signalling network in mesothelioma
Authors: A.-M. Baird, M. Jarzabek, L. Shiels, S. Raeppel, S. Finn, S. Cuffe, H.I. Pass, I. Schmitt-Opitz, A.T. Byrne, S.G. Gray
Journal: Annals of Oncology (2017)
Abstract #1544: STAT3 is critical for the regulation of HIF-1 in head and neck squamous cell carcinoma
Authors: Yan Zang, Claudia Velosa-Ramirez, Sufi Thomas, Erin Childs, William Gooding, Daniel Johnson, Jennifer Grandis, Stephen Lai
Journal: Cancer Research (2009)

Introduction: Dysregulation of signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1 (HIF-1) contributes to disease progression in a variety of human tumors. We examined the role of STAT3 in the oxygen-dependent and -independent regulation of HIF-1 activity in head and neck squamous cell carcinoma (HNSCC). Methods:A STAT3 oligonucleotide decoy was employed to disrupt STAT3 transcriptional function with subsequent assessment of HIF-1 function and cellular apoptosis in vitro. The effect of the STAT3 decoy on tumor growth and HIF-1\#945; expression was measured in an HNSCC xenograft model. Results: The induction of HIF-1\#945; expression and HIF-1 transcriptional activity following exposure to hypoxia or epidermal growth factor (EGF) was disrupted by the STAT3 decoy as compared to a mutant control decoy (p = 0.014; exact Wilcoxon test). Treatment of HNSCC cells with the STAT3 decoy led to increased cellular apoptosis, which could be prevented with the constitutive expression of a degradation-resistant HIF-1\#945; mutant (HIF-1\#945; /P564A). The STAT3 decoy also inhibited tumor growth in vivo (p = 0.0312; signed rank test) and resulted in decreased xenograft tumor expression of HIF-1\#945; (p = 0.0547; signed rank test). Conclusions: These findings demonstrate that STAT3 regulates HIF-1 in HNSCC under both oxygen-dependent (hypoxia) and -independent (EGF) conditions. Although there have been reports describing an interaction between HIF-1 and STAT3, our findings are the first to demonstrate the critical role of STAT3 in the overall regulation of HIF-1. These findings suggest that inhibiting STAT3 activity may be sufficient to target HIF-1 effectively in HNSCC.  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 1544.
Clinical outcome of cyberknife radiosurgery in brain metastases of non-small cell lung cancer: A single institutional experience
Authors: S.-W. Lee, Y.-S. Kim, Y.K. Won, S.J. Lee, J.H. Hong, Y.N. Kang, J.H. Kang, S.-H. Hong, S.J. Kim, Y.K. Kim
Journal: Annals of Oncology (2017)
RUNX1 Mutation in Cytogenetically Normal Acute Myeloid Leukemia : Clinical Implications, Co-Mutation Analysis
Authors: Seung-Shin Lee, Jae-Sook Ahn, Taehyung Kim, Hyeoung Joon Kim, Yeo-Kyeoung Kim, Seo-Yeon Ahn, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Hee Jung ParK, Seung Hyun Choi, Chul Won Jung, Jun-Ho Jang, Heeje Kim, Joon Ho Moon, Sang Kyun Sohn, Jong-Ho Won, Sung-Hyun Kim, Zhaolei Zhang, Dennis Dong Hwan Kim
Journal: Blood (2016)
Proteomic profile of cystic fibrosis sputum cells in adults chronically infected with <i>Pseudomonas aeruginosa</i>
Authors: Sally H. Pattison, David S. Gibson, Elinor Johnston, Samantha Peacock, Keith Rivera, Michael M. Tunney, Darryl J. Pappin, J. Stuart Elborn
Journal: European Respiratory Journal (2017)

Lung disease is the main cause of morbidity and mortality in cystic fibrosis (CF), and involves chronic infection and perturbed immune responses. Tissue damage is mediated mostly by extracellular proteases, but other cellular proteins may also contribute to damage through their effect on cell activities and/or release into sputum fluid by means of active secretion or cell death.We employed MudPIT (multidimensional protein identification technology) to identify sputum cellular proteins with consistently altered abundance in adults with CF, chronically infected with Pseudomonas aeruginosa, compared with healthy controls. Ingenuity Pathway Analysis, Gene Ontology, protein abundance and correlation with lung function were used to infer their potential clinical significance.Differentially abundant proteins relate to Rho family small GTPase activity, immune cell movement/activation, generation of reactive oxygen species, and dysregulation of cell death and proliferation. Compositional breakdown identified high abundance of proteins previously associated with neutrophil extracellular traps. Furthermore, negative correlations with lung function were detected for 17 proteins, many of which have previously been associated with lung injury.These findings expand our current understanding of the mechanisms driving CF lung disease and identify sputum cellular proteins with potential for use as indicators of disease status/prognosis, stratification determinants for treatment prescription or therapeutic targets.
Prevalence of hepatitis B virus and hepatitis C virus infection among six ethnic groups living in Amsterdam, the Netherlands – The HELIUS study
Authors: F. Zuure, J. Bil, M. Visser, G. van Rijckevorsel, M. Snijder, P. Blom, G. Sonder, J. Schinkel, M. Prins
Journal: Journal of Hepatology (2017)
Reply to Heatley and Bell
Authors: T.  Rabenstein, S.  Naegele-Jackson, E.  G.  Hahn, M.  Sackmann, J.  Maiss
Journal: Endoscopy (2003)

The letter to the Editor by Dr. Heatley and Prof. Bell refers to an article published by our group in Endoscopy several months ago [1]. On the basis of studies that were published between 1993 and 1998, they argue that it is inappropriate in feasibility studies of tele-endoscopy to focus exclusively on the picture quality. They state that it is ”important to take in wider considerations, such as cost, flexibility, availability, medical practices, audio requirements, etc.”. In our view, however, a new technology should initially be evaluated in high-quality feasibility studies that examine the focal point, and secondly in comparative studies to demonstrate its equality or superiority to existing techniques. In addition, it is important to take into account appropriate clinical applications and the demand for a new technique.
Metabolic signatures of chronic hepatitis C evolution revealed by transcriptome profiling of virus-specific CD8 cells across different stages of HCV infection
Authors: V. Barili, P. Fisicaro, B. Montanini, G. Acerbi, F. Guerrieri, A. Orlandini, E. Negri, C. Mori, M.C. Cavallo, M. Massari, G. Missale, M. Levrero, S. Ottonello, C. Ferrari
Journal: Journal of Hepatology (2017)
Pharmacokinetics, safety and antiviral activity of CMX157, a novel prodrug of tenofovir, administered as ascending multiple doses to healthy volunteers and Hepatitis B virus-infected subjects
Authors: T. Tanwandee, S. Chatsiricharoenkul, S. Thongsawat, W. Sukeepaisarnjaroen, P. Tangkijvanich, P. Komolmit, A. Avihingsanon, T. Piratvisuth, P. Sunthi, T. Mahasanprasert, T. Matkovits, M. Conover, J. Cobb, C. Canizares, J. Sullivan-Bolyai
Journal: Journal of Hepatology (2017)
Severity strata for Eczema Area and Severity Index (<scp>EASI</scp>), modified<scp>EASI</scp>, Scoring Atopic Dermatitis (<scp>SCORAD</scp>), objective<scp>SCORAD</scp>, Atopic Dermatitis Severity Index and body surface area in adolescents and adults with atopic dermatitis
Authors: R. Chopra, P.P. Vakharia, R. Sacotte, N. Patel, S. Immaneni, T. White, R. Kantor, D.Y. Hsu, J.I. Silverberg
Journal: British Journal of Dermatology (2017)

Scoring systems for assessing the signs of atopic dermatitis (AD) are complex and difficult to interpret. Severity strata are helpful to interpret these assessments properly.To confirm previously reported strata for the Eczema Area and Severity Index (EASI), Scoring Atopic Dermatitis (SCORAD) and the objective component of SCORAD (oSCORAD), and to develop strata for the modified EASI (mEASI), Atopic Dermatitis Severity Index (ADSI) and body surface area (BSA) for use in adults with AD.Skin examination was performed in 673 adolescents and adults (age ≥ 13 years) with diagnosed AD, in a dermatology practice setting. Strata were selected using an anchoring approach based on a four-point Investigator's Global Assessment of severity (clear of active skin lesions, mild, moderate or severe disease).We determined potential severity strata for EASI (0 clear, 0·1-5·9 mild, 6·0-22·9 moderate, 23·0-72 severe; κ = 0·69), mEASI (0-0·9 clear, 1-8·9 mild, 9·0-29·9 moderate, 30·0-90 severe; κ = 0·71), oSCORAD (0-7·9 clear, 8·0-23·9 mild, 24·0-37·9 moderate, 38·0-83 severe; κ = 0·70), SCORAD (0-9·9 clear, 10·0-28·9 mild, 29·0-48·9 moderate, 49·0-103 severe; κ = 0·68), ADSI (0-1·9 clear, 2-5·9 mild, 6·0-8·9 moderate, 9·0-15 severe; κ = 0·55) and BSA (0 clear, 0·1-15·9 mild, 16·0-39·9 moderate, 40·0-100 severe; κ = 0·66). oSCORAD values > 0 were found in clear skin due to the presence of xerosis, which is scored in oSCORAD. Similarly, SCORAD values > 0 were found in clear skin due to the scoring of xerosis, pruritus and sleeplessness. Similarly, mEASI and ADSI scores > 0 occurred in patients with clear skin due to scoring of pruritus.We recommend using these strata for interpretation of their respective measures in clinical trials of AD. There are important differences between the five assessments, which profoundly impact the interpretation of their scores.
Expression and circulating levels of lymphangiogenic parameters in renal cell cancer: Implication for antiangiogenic treatments
Authors: R. Mouawad, E. Comperat, J. P. Spano, H. Izzedine, F. Cajfinger, G. Deray, F. Capron, D. Khayat
Journal: Journal of Clinical Oncology (2009)

e16144 Background: Vascular endothelial growth factors C, VEGF-D and VEGFR-2, R-3, are overexpressed in different malignancies and associated with lymph node metastasis and poor prognosis. In renal cell cancer (RCC) lymphatic tumor spread exist but data focusing on lymphangiogenesis are rare. Since the VEGF-C/VEGF-D/VEGFR-2, R-3 axis appears to be the signaling pathway for tumor-induced lymphangiogenesis and an attractive target for therapeutic intervention; we analyzed the expression and the presence of the soluble forms in 30 RCC patients and results were correlated with clinicopathological parameters. Methods: Tumor and sera from 30 RCC patients (20 clear cell (ccRCC)&amp;10 papillary (pRCC) were included in this study. The expressions of VEGFR-2,R-3 &amp;VEGF-C,-D expressions on tumor were evaluated by immunohistochemestry. Using ELISA assays, sVEGFR-2, R-3 &amp;sVEGF-C,-D were measured in sera of RCC patients in comparison to 20 healthy controls. Results: In overall patients, a high expression of VEGF-C,-D and their receptors were observed in more than 55%of the patients as compared to the negative control. Regarding circulating VEGF-C,-D, R2, R-3 they were variable in all samples from either patients or healthy donors. Only median sVEGF- R3 level was significantly higher (p=0.005) in RCC patients as compared to healthy donors. VEGF-C and VEGF-D expression was significantly correlated (r’=0.43, p=0.02) with each other but not with the expression of its receptors. An inverse correlation between Flt-4 expression &amp; its soluble form was noted (r=-0.33 p=0.040). The expression of VEGF-C, VECF-D and sVEGFR-3 were significantly higher in pRCC than ccRCC (p=0.02, 0.01 and 0.035 respectively). The expression of VEGFR-2,VEGFR-3 were not different between the subgroups (p=0.11). Furthermore, no correlation with clinicopathological parameters was shown in either overall patients or in the two subgroups. Conclusions: we showed that in RCC the lymphangiogenic factors are expressed or present as soluble form, a different expression pattern in ccRCC and pRCC existe. Therefore, further studies are necessary to determine if lymphangiogenesis can play a role as a prognostic tool or a target for therapeutic intervention in renal cell carcinoma. No significant financial relationships to disclose.
Clinical impact of induction chemotherapy followed by surgery for gastric cancer with positive peritoneal cytology.
Authors: Masaki Aizawa, Atsushi Matsuki, Hiroshi Yabusaki, Atsushi Nashimoto
Journal: Journal of Clinical Oncology (2014)

4050 Background: The gastric cancer patients with peritoneal metastasis have poor survival. Nevertheless, the survival rate in patients who accompany with positive peritoneal cytology as only the evidence of distant metastasis has been superior to that in patients with overt peritoneal dissemination. In such patients, the combination of preoperative chemotherapy and surgery may enable to perform potentially R0 resection. The aim of this study was to verify the clinical significance of R0 resection following the clearance of free cancer in the peritoneal cavity. Methods: The retrospective study was conducted using a prospectively maintained database. A total of 53 gastric cancer patients with free cancer cells in the peritoneal cavity, as evaluated by staging laparoscopy between January 2001 and December 2010, but no other evidence of distant metastasis, which underwent induction chemotherapy (mostly S-1+cisplatin regimen) followed by surgery were identified. Then, the correlation between clinicopathological features and the prognosis was assessed by COX proportional hazards analysis. Results: The MST and 5-year OS rate of the 53 study participants were 19.7 months and 25.6%, respectively. In 28 patients, the peritoneal cytology converted from positive to negative after the induction chemotherapy, and microscopically margin negative gastrectomy was performed subsequently. The MST of 31.4 months and 5-year OS rate of 36.1% of these patients were significantly more favorable than the corresponding values of 12.7 months and 15.0% in the patients who failed to diminish the free cancer cell in the peritoneal cavity (P< 0.001). Multivariate survival analysis identified the residual tumor (HR: 3.419, 95%CI: 1.695-6.895, p=0.001) as well as macroscopic Type 4 tumor (HR: 2.636, 95%CI: 1.022-6.798, p=0.04) as an independent prognostic factor. Conclusions: The conversion of positive peritoneal cytology by induction chemotherapy might improve the prognosis. The results suggested an adequate impact to accept the induction chemotherapy followed by surgery with curative intent for gastric cancer patients with positive peritoneal cytology as only the evidence of metastasis.
Discovery of Predictive Gene Signatures for Tumor Sensitivity to MDM2 Inhibition in Development of a Novel MDM2 Inhibitor DS-3032b
Authors: Jo Ishizawa, Kenji Nakamaru, Takahiko Seki, Koichi Tazaki, Kensuke Kojima, Dhruv Chachad, Courtney D DiNardo, Sherry Pierce, Keyur P. Patel, Archie Tse, R Eric Davis, Arvind Rao, Michael Andreeff
Journal: Blood (2016)
Hepatitis C virus clearance after direct-acting antivirals in cirrhotic patients by stages of liver impairment: the ITAL-C network study
Authors: A.M. Ippolito, M. Milella, V. Messina, F. Conti, R. Cozzolongo, F. Morisco, G. Brancaccio, M. Barone, T. Santantonio, M. Fasano, C. Masetti, P. Tundo, A. Smedile, V. Carretta, P. Gatti, A.P. Termite, M.R. Valvano, G. Bruno, C. Fabrizio, P. Andreone, M. Zappimbulso, G.B. Gaeta, N. Napoli, L. Fontanella, G. Lauletta, G. Cuccorese, A. Metrangolo, R. Francavilla, E. Ciracì, S. Rizzo, A. Andriulli
Journal: Journal of Hepatology (2017)
Impact of hepatic steatosis and controlled attenuation parameter (CAP) on accuracy of fibrosis staging using transient elastography
Authors: T. Karlas, D. Petroff, M. Sasso, J.-G. Fan, Y.-Q. Mi, V. de Lédinghen, M. Kumar, M. Lupsor-Platon, K.-H. Han, A.C. Cardoso, G. Ferraioli, W.-K. Chan, V.W.-S. Wong, R.P. Myers, K. Chayama, M. Friedrich-Rust, M. Beaugrand, F. Shen, J.-B. Hiriart, S.K. Sarin, R. Badea, K.S. Jung, P. Marcellin, C. Filice, S. Mahadeva, G.L.-H. Wong, P. Crotty, K. Masaki, J. Bojunga, P. Bedossa, V. Keim, J. Wiegand
Journal: Journal of Hepatology (2017)
Cancer Screening, Overdiagnosis, and Regulatory Capture
Authors: H. Gilbert Welch
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Ischaemic-reperfusion injury and different risk factors for acute kidney injury in donation after circulatory death liver transplantation. UK single centre study
Authors: I. Umbro, F. Tinti, F. Evison, M. Kalisvaart, A. Sharif, B. Gunson, A.P. Mitterhofer, J. Ferguson, P. Muiesan
Journal: Journal of Hepatology (2017)
Exercise therapy for functional capacity in chronic diseases: an overview of meta-analyses of randomised controlled trials
Authors: Tero Pasanen, Samppa Tolvanen, Ari Heinonen, Urho M Kujala
Journal: British Journal of Sports Medicine (2017)

Objective To summarise all meta-analyses of randomised controlled trials that have evaluated the effects of exercise therapy on functional capacity in patients with chronic diseases. Design Umbrella review of meta-analyses of randomised controlled trials. Data sources We systematically searched the CENTRAL, CINAHL, DARE, Medline, OTSeeker, PEDro, SPORTDiscus, ProQuest Nursing &amp; Allied Health Database, Web of Science, Scopus, OpenGrey and BMC Proceedings from database inception to 1 September 2016. Eligibility criteria for selecting studies We included meta-analyses that compared the effects of exercise therapy with no treatment or usual care in adults with non-communicable chronic diseases and included outcomes related to functional capacity. We excluded meta-analyses with less than 100 patients. Results Eighty-five meta-analyses with 22 different chronic diseases were included. The exercise interventions resulted in statistically significant (p&lt;0.05) improvements for 126 of 146 (86%) functional capacity outcomes, compared with the control group. The standardised mean differences were small in 64 (44%), moderate in 54 (37%) and large in 28 (19%) of the 146 functional capacity outcomes. The results were similar for aerobic exercise, resistance training, and aerobic and resistance training combined. There were no significant differences in serious adverse effects between the intervention and control groups in any of the meta-analyses. Conclusion Exercise therapy appears to be a safe way to improve functional capacity and reduce disability in individuals with chronic disease.
Point shear wave elastography (ElastPQ) is a reliable non-invasive tool for the diagnosis and characterisation of portal hypertension
Authors: M. Rosselli, D. Roccarina, D. Patch, M. Sekhar, A. Majumdar, J. O’Beirne, D. Thorburn, E. Tsochatzis, M. Pinzani
Journal: Journal of Hepatology (2017)
MESENTERIC FIBROSIS IN PATIENTS WITH SMALL BOWEL CARCINOID TUMOURS: IMPACT ON QUALITY OF LIFE AND SURVIVAL
Authors: Raj Srirajaskanthan, C. Toumpanakis, A. Sogbodjor, K. Desai, A. Krepska, L. Marelli, M. Winslett, G. Ogunbyi, M. Caplin
Journal: Gut (2009)
The severity of steatosis does not influence liver stiffness measurements in patients with Non-Alcoholic Fatty Liver Disease
Authors: R. Forlano, J. Maurice, B.H. Mullish, N. Angkathunyakul, E. Goldin, G. Serviddio, M. Yee, N. Giannakeas, A.T. Tzallas, M.G. Tsipouras, S. Khan, S. Taylor-Robinson, R.D. Goldin, M. Thursz, P. Manousou
Journal: Journal of Hepatology (2017)