tbuckley/cabot-search huggingface dataset:
A CD123-Targeting Antibody-Drug Conjugate (ADC), IMGN632, Designed to Eradicate Acute Myeloid Leukemia (AML) Cells While Sparing Normal Bone Marrow Cells
Authors: Yelena Kovtun, Gregory Jones, Charlene Audette, Lauren Harvey, Baudouin Gerard, Alan Wilhelm, Chen Bai, Sharlene Adams, Victor S Goldmacher, Ravi Chari, Thomas Chittenden
Journal: Blood (2016)
Prevalence and clinical impact of rectal colonization by multidrug-resistant bacteria in critically ill patients with and without cirrhosis
Authors: V.E.P. Gonzalez, F. Marco, M. Arteaga, E. Reverter, A. Escorsell, A. Carpio, G. Mezzano, S. Rodríguez, A. Juanola, J. Mensa, P. Ginés, A. Soriano, J. Vila, J. Fernandez
Journal: Journal of Hepatology (2017)
Outlier in Analysis of Cancer Mortality by US County
Authors: Jaclyn M. Hall, Elizabeth A. Shenkman, Chiung-Shiuan Fu
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and safety of front-line bevacizumab (BEV), weekly paclitaxel (wPAC), and q3w carboplatin (C) in elderly patients (pts) with ovarian cancer (OC): Subgroup analysis of OCTAVIA.
Authors: Antonio Gonzalez-Martin, Laurence Gladieff, Bengt Tholander, Daniel Stroyakovsky, Martin Eric Gore, Hendrika M Oosterkamp, Alla Lisyanskaya, Andrés Redondo, Eric Teissier, Per Rosenberg, Julian Perez Ronco, Ulrich Freudensprung, Sandro Pignata
Journal: Journal of Clinical Oncology (2013)

5544 Background: Front-line BEV significantly improved PFS when combined with q3w paclitaxel and C in two randomized phase III OC trials. The single-arm OCTAVIA study combined two successful strategies, anti-angiogenic therapy and wPAC administration, demonstrating median PFS of 24 months at the primary analysis [IGCS 2012]. We report exploratory analyses of safety and efficacy in the subgroup of pts aged ≥65 y treated in OCTAVIA. Methods: Pts received 6–8 cycles of BEV (7.5 mg/kg, d1) + wPAC (80 mg/m 2 d1, 8, 15) + C (AUC 6, d1) iv q3w, with BEV q3w continued alone for a total of up to 17 cycles (1 y) as front-line therapy for newly diagnosed OC (FIGO stage I–IIa [grade 3/clear cell] or stage IIb–IV [any grade]). The primary endpoint was PFS. Results: Of the189 treated pts, 37 (20%) were aged ≥65 y (11% 65–&lt;70 y; 6% 70–&lt;75 y; 3% ≥75 y). Compared with pts aged &lt;65 y, the subgroup of pts aged ≥65 y included fewer pts with no residual disease after surgery (24% vs 34%) and more pts with grade 3 OC (62% vs 55%) or comorbidities at baseline (hypertension: 38% vs 17%; dyslipidemia: 14% vs 5%). Pts aged ≥65 y received a median of 6 chemotherapy cycles (range 1–8) and 17 BEV cycles (range 0–18). C or wPAC was given for ≥6 cycles to 86% and 68% of pts, respectively. AEs led to early discontinuation of C, wPAC, or BEV in 14%, 38%, and 14% of pts, respectively. After median follow-up of 26.5 months and events in 62%, median PFS was 20.5 mo (95% CI 17.8–29.1 mo) in the elderly subgroup. Seven pts (19%) had died, all from disease progression; the 1-y OS rate was 97.3%. The most common grade ≥3 AEs were hematologic (neutropenia 62%, thrombocytopenia 14%), with no major differences according to age. Overall, there was a numerically higher incidence of grade 3/4 AEs in pts aged ≥65 vs &lt;65 y (86% vs 76%, respectively), driven by non-hematologic AEs. The incidences of grade ≥3 AEs of special interest were similar in older and younger pts, except for hypertension (11% in pts ≥65 y vs 3% in pts &lt;65 y) and bleeding (3% vs 0%, respectively). Conclusions: BEV combined with wPAC and C is a feasible, well-tolerated, active front-line regimen, even in the small subgroup of pts aged ≥65 y, many of whom had comorbidities. Clinical trial information: NCT00937560.
LONG-TERM SURVIVAL OF PATIENTS WITH RESECTION OF PULMONARY METASTASES FROM COLORECTAL NEOPLASMS AS COMPARED TO NOT RESECTED ONES. A RETROSPECTIVE STUDY ON PATIENTS FOLLOWED FROM THE TIME OF FIRST RECURRENCE
Authors: Tampellini Marco, Ottone Azzurra, Bellini Elisa, Alabiso Irene, Leone Francesco, Miraglia Stefania, Alabiso Oscar, Aglietta Massimo, Dogliotti Luigi
Journal: Annals of Oncology (2011)
Hemoglobin S Screening Using the « Sickle Scan » - Biomedomics System. the Necker-Enfants Malades Hospital Experience
Authors: Louis MINE, Thao Nguyen-Khoa, Birch Allaf, Jean-Antoine Ribeil, Christelle Remus, Valérie Gauthereau, Sarah Enouz, Jason S. KIM, Xiaoxi Yang, Eliane Gluckman, Arnold Munnich, Marina Cavazzana, Robert Girot
Journal: Blood (2016)
Displaced middle-third clavicle fracture management in sport: still a challenge in 2018. Should you call the surgeon to speed return to play?
Authors: Greg A Robertson, Alexander M Wood, Christopher W Oliver
Journal: British Journal of Sports Medicine (2017)

The management of clavicle fractures should be guided by fracture location (middle-third/lateral/medial) and fracture configuration (undisplaced/displaced/comminuted).1–5 Current management guidelines recommend surgical management for middle-third fractures, which are completely displaced, shortened by 2 cm or comminuted, as this can facilitate an earlier return to sport and improve final shoulder function.2 3 5 

Our systematic review assessed all clavicle fracture studies that recorded return to sport, to determine the effect of different treatment methods on return rates and times to sport.6 Twenty-three studies were included: 8 were prospective cohort studies, 15 were retrospective cohort studies.6 

Here we summarise the results from that systematic review, to determine the optimal management of middle-third clavicle fractures. Such information provides sport physicians and surgeons with an evidence-based treatment algorithm for these injuries, allowing optimisation of return rates and times to sport for affected athletes.

The systematic review was collated following a search of: CINAHAL, Cochrane, EMBASE, Google Scholar, Medline, PEDro, Scopus, SPORTDiscus, Web of …
MET Exon 14 Skipping Mutations in Lung Adenocarcinoma: Clinicopathologic Implications and Prognostic Values
Authors: Geun Dong Lee, Seung Eun Lee, Doo-Yi Oh, Dan-bi Yu, Hae Min Jeong, Jooseok Kim, Sungyoul Hong, Hun Soon Jung, Ensel Oh, Ji-Young Song, Mi-Sook Lee, Mingi Kim, Kyungsoo Jung, Jhingook Kim, Young Kee Shin, Yoon-La Choi, Hyeong Ryul Kim
Journal: Journal of Thoracic Oncology (2017)
Entecavir or tenofovir monotherapy prevents hepatitis B virus recurrence in liver transplant recipients: a 5-year follow-up study after hepatitis B immunoglobulin withdrawal
Authors: M.A. Manini, M. Bruce, G. Whitehouse, I. Carey, B. Wang, E. Gonsalkorala, A. Considine, M. Heneghan, P. Lampertico, K. Agarwal
Journal: Journal of Hepatology (2017)
666 human cost of “motorcycle mass transit”: report of 9,000 fatalities from urban road injury surveillance in a developing country
Authors: Rashid Jooma
Journal: BMJ (2016)

Background  Many of the burgeoning megacities in developing countries have witnessed poorly planned urban sprawls. The absence of a coherent mass public transport system encourages the acquisition of inexpensive motorcycles for commuting and this has distorted the traffic mix. In Karachi the proportion of motorcycles on the road has risen from 34% of registered vehicles to 55% over the past decade. We have sought to assess the impact of this on road use fatalities by analysis of data captured by ongoing road traffic injury surveillance based in 5 city hospitals.  Methods  The recorded road-use deaths were those dying within 30 days of being admitted to hospital and included cases brought dead to the EDs or the mortuaries of the hospitals. The case information included gender, age, number of vehicles involved in the crash, road-user type (motorcycle rider or pillion rider), helmet use and injury scoring.  Results  During 8 years, 2007–2014, motorcycle occupants accounted for 3901 of the 9192 fatalities and over the study period these increased from 36% to 53% of the recorded road deaths (p   Conclusions  An escalating socio-economic tragedy is being played out in the urban centres of many developing countries by the juxtaposition of poor public transport and availability of inexpensive motorcycles. Our study suggests that while the implementation of mass transit schemes are awaited, strategies that segregate traffic and reduce speeds should be prioritised along with strict enforcement of helmet laws.
Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129
Authors: Wen-Bo Zeng, Hai-Fei Jiang, Ya-Dong Gang, Yi-Ge Song, Zhang-Zhou Shen, Hong Yang, Xiao Dong, Yong-Lu Tian, Rong-Jun Ni, Yaping Liu, Na Tang, Xinyan Li, Xuan Jiang, Ding Gao, Michelle Androulakis, Xiao-Bin He, Hui-Min Xia, Ying-Zi Ming, Youming Lu, Jiang-Ning Zhou, Chen Zhang, Xue-Shan Xia, Yousheng Shu, Shao-Qun Zeng, Fuqiang Xu, Fei Zhao, Min-Hua Luo
Journal: Molecular Neurodegeneration (2017)

Herpes simplex virus type 1 strain 129 (H129) has represented a promising anterograde neuronal circuit tracing tool, which complements the existing retrograde tracers. However, the current H129 derived tracers are multisynaptic, neither bright enough to label the details of neurons nor capable of determining direct projection targets as monosynaptic tracer.Based on the bacterial artificial chromosome of H129, we have generated a serial of recombinant viruses for neuronal circuit tracing. Among them, H129-G4 was obtained by inserting binary tandemly connected GFP cassettes into the H129 genome, and H129-ΔTK-tdT was obtained by deleting the thymidine kinase (TK) gene and adding tdTomato coding gene to the H129 genome. Then the obtained viral tracers were tested in vitro and in vivo for the tracing capacity.H129-G4 is capable of transmitting through multiple synapses, labeling the neurons by green florescent protein, and visualizing the morphological details of the labeled neurons. H129-ΔTK-tdT neither replicates nor spreads in neurons alone, but transmits to and labels the postsynaptic neurons with tdTomato in the presence of complementary expressed TK from a helper virus. H129-ΔTK-tdT is also capable to map the direct projectome of the specific neuron type in the given brain regions in Cre transgenic mice. In the tested brain regions where circuits are well known, the H129-ΔTK-tdT tracing patterns are consistent with the previous results.With the assistance of the helper virus complimentarily expressing TK, H129-ΔTK-tdT replicates in the initially infected neuron, transmits anterogradely through one synapse, and labeled the postsynaptic neurons with tdTomato. The H129-ΔTK-tdT anterograde monosynaptic tracing system offers a useful tool for mapping the direct output in neuronal circuitry. H129-G4 is an anterograde multisynaptic tracer with a labeling signal strong enough to display the details of neuron morphology.
Identification of Targetable <i>ALK</i> Rearrangements in Pancreatic Ductal Adenocarcinoma
Authors: Aatur D. Singhi, Siraj M. Ali, Jill Lacy, Andrew Hendifar, Khanh Nguyen, Jamie Koo, Jon H. Chung, Joel Greenbowe, Jeffrey S. Ross, Marina N. Nikiforova, Herbert J. Zeh, Inderpal S. Sarkaria, Anil Dasyam, Nathan Bahary
Journal: Journal of the National Comprehensive Cancer Network (2017)

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a 5-year survival of 8%. Current therapeutic regimens are largely ineffective and underscore the need for novel treatment strategies. Chromosomal rearrangements involving the anaplastic lymphoma kinase (ALK) gene have been identified in several neoplasms. In addition, ALK protein inhibitors have proven efficacy in patients with ALK-rearranged tumors. However, ALK translocations in PDAC have not been described. Through comprehensive genomic profiling of 3,170 PDACs, we identified 5 cases (0.16%) that harbored an ALK fusion gene: an exon 6 EML4–exon 20 ALK translocation (n=3), an exon 13 EML4–exon 20 ALK translocation (n=1), and an exon 3 STRN–exon 20 ALK translocation (n=1). Among the most prevalent PDAC-related genes, activating KRAS mutations were absent in all 5 cases, who were <50 years of age. Among patients aged <50 years in our study cohort, ALK translocations constituted 1.3% of PDACs. Four of 5 patients were treated with an ALK inhibitor, and 3 of these patients demonstrated stable disease, radiographic response, and/or normalization of serum CA 19-9. Although rare, ALK fusions occur in PDAC, and screening for ALK rearrangements should be considered in young patients with PDAC.
Montgomery and informed consent: where are we now?
Authors: Sarah W Chan, Ed Tulloch, E Sarah Cooper, Andrew Smith, Wojtek Wojcik, Jane E Norman
Journal: BMJ (2017)

The Montgomery case in 2015 was a landmark for informed consent in the UK. Two years on, Sarah Chan and colleagues discuss the consequences for practising doctors

The Montgomery v Lanarkshire case of March 20151 drew fresh attention to informed consent. Nadine Montgomery, a woman with diabetes and of small stature, delivered her son vaginally; he experienced complications owing to shoulder dystocia, resulting in hypoxic insult with consequent cerebral palsy. Her obstetrician had not disclosed the increased risk of this complication in vaginal delivery, despite Montgomery asking if the baby’s size was a potential problem. Montgomery sued for negligence, arguing that, if she had known of the increased risk, she would have requested a caesarean section. The Supreme Court of the UK announced judgment in her favour in March 2015. The ruling overturned a previous decision by the House of Lords,2 which had been law since at least the mid 1980s.3 It established that, rather than being a matter for clinical judgment to be assessed by professional medical opinion, a patient should be told whatever they want to know, not what the doctor thinks they should be told.

Many organisations (in particular the General Medical Council, who intervened to make submissions in the case) said that the Montgomery decision had simply enabled UK law to catch up with current GMC guidance; others hailed it “the most important UK judgment on informed consent for 30 years.”4 Doctors have expressed their concerns about its potentially radical effects on patient care and clinical practice.5 We held a public debate in 2015, including doctors, lawyers, and medical students, which showed renewed tension between the professional discretion of doctors and patients’ choices6; indeed, the verdict has been characterised as supporting patient autonomy over medical paternalism.378 …
ZIRCON: pharmacokinetics, safety, and efficacy of ombitasvir/ paritaprevir/ritonavir ± dasabuvir ± ribavirin in adolescents with genotype 1 or 4 hepatitis C virus infection
Authors: D.H. Leung, B. Yao, R.M. Viani, R.P. Gonzalez-Peralta, M.M. Jonas, S.J. Lobritto, M.R. Narkewicz, E. Sokal, C. Fortuny, E. Hsu, S. Wirth, A. Del Valle-Segarra, J. Zha, L. Larsen, L. Liu, D.L. Shuster, D.E. Cohen, P. Rosenthal
Journal: Journal of Hepatology (2017)
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Authors: Ahmet Zehir, Ryma Benayed, Ronak H Shah, Aijazuddin Syed, Sumit Middha, Hyunjae R Kim, Preethi Srinivasan, Jianjiong Gao, Debyani Chakravarty, Sean M Devlin, Matthew D Hellmann, David A Barron, Alison M Schram, Meera Hameed, Snjezana Dogan, Dara S Ross, Jaclyn F Hechtman, Deborah F DeLair, JinJuan Yao, Diana L Mandelker, Donavan T Cheng, Raghu Chandramohan, Abhinita S Mohanty, Ryan N Ptashkin, Gowtham Jayakumaran, Meera Prasad, Mustafa H Syed, Anoop Balakrishnan Rema, Zhen Y Liu, Khedoudja Nafa, Laetitia Borsu, Justyna Sadowska, Jacklyn Casanova, Ruben Bacares, Iwona J Kiecka, Anna Razumova, Julie B Son, Lisa Stewart, Tessara Baldi, Kerry A Mullaney, Hikmat Al-Ahmadie, Efsevia Vakiani, Adam A Abeshouse, Alexander V Penson, Philip Jonsson, Niedzica Camacho, Matthew T Chang, Helen H Won, Benjamin E Gross, Ritika Kundra, Zachary J Heins, Hsiao-Wei Chen, Sarah Phillips, Hongxin Zhang, Jiaojiao Wang, Angelica Ochoa, Jonathan Wills, Michael Eubank, Stacy B Thomas, Stuart M Gardos, Dalicia N Reales, Jesse Galle, Robert Durany, Roy Cambria, Wassim Abida, Andrea Cercek, Darren R Feldman, Mrinal M Gounder, A Ari Hakimi, James J Harding, Gopa Iyer, Yelena Y Janjigian, Emmet J Jordan, Ciara M Kelly, Maeve A Lowery, Luc G T Morris, Antonio M Omuro, Nitya Raj, Pedram Razavi, Alexander N Shoushtari, Neerav Shukla, Tara E Soumerai, Anna M Varghese, Rona Yaeger, Jonathan Coleman, Bernard Bochner, Gregory J Riely, Leonard B Saltz, Howard I Scher, Paul J Sabbatini, Mark E Robson, David S Klimstra, Barry S Taylor, Jose Baselga, Nikolaus Schultz, David M Hyman, Maria E Arcila, David B Solit, Marc Ladanyi, Michael F Berger
Journal: Nature Medicine (2017)
Optimizing Progenitor Cell Mobilization in Patients with Myeloma: Effect of a Pre-Emptive Day 4 Plerixafor-Based Mobilization Algorithm
Authors: Omotayo O. Fasan, Saad Z Usmani, Danyu Sun, Ryan Jacobs, Carlos Lee, Jigar Trivedi, Eric Chow, Dragos Plesca, Manisha Bhutani, Belinda R. Avalos, Edward A. Copelan
Journal: Blood (2016)
THE EPIDEMIOLOGY OF FOWL CHOLERA
Authors: Thomas P. Hughes, Ida W. Pritchett
Journal: The Journal of Experimental Medicine (1930)

1. In the experiments here presented, P. avicida proved incapable of inciting fowl cholera when introduced directly into the alimentary tract. On the other hand, when administered into the upper respiratory passages, it induced typical disease. 2. When P. avicida was introduced into the nasal passages of controlled, selected chickens, some died of typical septicemic cholera, a few developed chronic pneumonias and other conditions and succumbed, a few developed localized upper respiratory inflammations, such as rhinitis, roup, and wattle involvement, while yet a few others became "healthy" nasal carriers. Usually, however, more than 50 per cent resisted infection. Repeated titrations of this sort gave, in general, uniform results, save that in spring and summer the per cent mortality decreased. 3. P. avicida was recovered from a number of cases of "spontaneous" roup, rhinitis, and wattle disease. 4. Groups of chickens reacted similarly to doses of virulent P. avicida varying from 20,000,000 to 20,000. Outside these limits, dosage exercised a marked influence on mortality.
Transplantation of T Cell Depleted Haploidentical HSCT Following Non-Myeloablative (NMA) Conditioning: Combining the Power of Megadose Transplants with Post Transplant Cyclophosphamide (PTCY)
Authors: Franco Aversa, Esther BacharLustig, Lucia Prezioso, Sabrina Bonomini, Noga Or Geva, Alessandro Monti, Ilenia Manfra, Chiara Schifano, Federica Galaverna, Yael Zlotnikov Klionsky, Yair Reisner
Journal: Blood (2016)
Evaluation of the CLIF-C ACLF score in critically ill cirrhotic patients in intensive care units in Europe and North America: a multicenter cohort study
Authors: C.J. Karvellas, E. Garcia-Lopez, J. Fernandez, F. Saliba, E. Sy, R. Jalan, M. Pavesi, T. Gustot, G. Mezzano, J.J. Ronco, V. Arroyo
Journal: Journal of Hepatology (2017)
Medical Education and the Minority Tax
Authors: Kali D. Cyrus
Journal: JAMA (2017)

I sat down at the large conference room table surrounded by the other medical students, some of whom I recognized from earlier stops on the residency interview trail. As they continued their conversations, I looked around, realizing I was once again the only interviewee who is black. I kept gazing around the room, only to find more faces staring back that did not look like me. Hanging grandly from the walls were faces, painted in watercolor, framed in bronze, and undoubtedly of really important men … really important white men.
Validity criteria for the diagnosis of fatty liver by M probe-based controlled attenuation parameter
Authors: Vincent Wai-Sun Wong, Salvatore Petta, Jean-Baptiste Hiriart, Calogero Cammà, Grace Lai-Hung Wong, Fabio Marra, Julien Vergniol, Anthony Wing-Hung Chan, Antonino Tuttolomondo, Wassil Merrouche, Henry Lik-Yuen Chan, Brigitte Le Bail, Umberto Arena, Antonio Craxì, Victor de Lédinghen
Journal: Journal of Hepatology (2017)
An evaluation of survival of ovarian cancer patients with clear cell carcinoma versus serous carcinoma treated with platinum therapy: A Gynecologic Oncology Group experience.
Authors: John H. Farley, William E. Brady, Michael J. Birrer, David Marc Gershenson, Gini F. Fleming
Journal: Journal of Clinical Oncology (2013)

5534 Background: We examined disparities in prognosis between patients with ovarian clear cell carcinoma (OCCC) and serous epithelial ovarian cancer (SOC). Methods: Data from stage I-IV epithelial ovarian cancer (EOC) patients who participated in 12 randomized GOG protocols using platinum-based chemotherapy were reviewed. Proportional hazards models adjusted for age and stratified by protocol, treatment arm, stage, performance status (PS), and race were used to compare progression-free survival (PFS) and overall survival (OS) by cell type (clear cell versus serous). Results: There were 10,803 patients enrolled, 1272 were not eligible: leaving 9,531, of whom 544 (6%) had OCCC, 7,054 (74%) had SOC, and 1,933 (20%) had other; only the OCCC and SOC are considered here. OCCC were significantly younger, more often of Asian race, stage I, good PS, and optimally surgically debulked than SOC patients. Prior to adjustment, OCCC had better PFS and OS due to better prognostic factors. There was no significant difference in PFS or OS for early stage OCCC patients compared to high-grade (HG) SOC patients. For late stage patients, OCCC had poorer PFS and OS compared to SOC, OS HR= 1.66 (1.43, 1.91; p &lt; 0.001). For both optimal, HR = 1.34 (1.10, 1.63; p = 0.003) and suboptimal, HR = 3.18 (2.13, 4.75; p &lt; 0.001) OCCC had a significantly poorer OS than SOC. After adjusting for age and stratified by protocol and treatment arm, stage, performance status, and race, OCCC had a significantly decreased OS, HR= 1.53 (1.33,1.76; p &lt; 0.001). In early stage cases, there was a significantly decreased treatment effect on PFS for consolidative therapy with weekly taxol versus observation in SOC compared to OCCC (p = 0.048). Conclusions: This is one of the largest analyses to date of OCCC treated in a uniform manner . OCCC patients have better PFS and OS compared to SOC; this, is due to their better prognostic factors. There was no observed difference in PFS or OS for early stage OCCC versus HGSOC. In late-stage patients, OCCC was significantly associated with decreased OS which was true for both optimal and suboptimally debulked patients. Finally, treatment effect was influenced by histology.
Irreversible inhibition of ornithine aminotransferase mediates hepatocellular carcinoma suppression is a result of inhibition of glutamine and beta-catenin and suppression of regulatory T cells: a novel mechanism for treatment of primary liver cancer
Authors: T. Khoury, D. Rotnemer-Golinkin, L. Zolotarev, J.I. Juncosa, R.B. Silverman, Y. Ilan
Journal: Journal of Hepatology (2017)