tbuckley/cabot-search huggingface dataset:
Guías BICHAT para el manejo clínico de la brucelosis y de la brucelosis relacionada con el bioterrorismo
Authors: P Bossi, A Tegnell, A Baka, F van Loock, J Hendriks, A Werner, H Maidhof, G Gouvras
Journal: Eurosurveillance (2004)

El interes en la Brucella species como arma biologica radica en que es posible la transmision aerea del agente. Es un agente muy contagioso que se introduce a traves de las membranas mucosas, como la conjuntiva, la orofaringe, el tracto respiratorio y las abrasiones cutaneas. Se estima que basta con 10-100 organismos para que una dosis aerosolizada resulte infecciosa para el hombre. Los signos y sintomas son similares en todos los pacientes, cualquiera sea su via de transmision, y casi nunca son especificos. Los sintomas de pacientes infectados por aerosol son identicos a los de pacientes infectados por otras vias. Los tratamientos a base de doxiciclina y estreptomicina, o de doxiciclina y rifampicina, son eficaces para casi todas las formas de brucelosis. No es necesario recurrir a la cuarentena del paciente. Los tratamientos a base de trimetoprim-sulfametoxazol y fluoroquinolonas tambien son eficaces contra la Brucella, pero estan asociados a una tasa elevada de recaida cuando se utilizan como monoterapias. La combinacion de ofloxacino y rifampicina obtiene buenos resultados. Incluso si hay pocas pruebas que justifiquen su utilidad como medida profilactica tras la exposicion, se recomienda administrar un tratamiento de doxiciclina combinada con rifampicina durante un periodo de 3 a 6 semanas.
Abstract 16906: Effectiveness of Tracking and Reporting Patient Radiation Exposure
Authors: Donald Lappe, Scott Allison, Jose Benuzillo, Colleen Roberts, Deanna Welch, Steve Taysom, Keith White
Journal: Circulation (2016)

Introduction:  Despite the life-saving benefits of fluoroscopic cardiovascular imaging, there is extensive scientific evidence that cumulative radiation exposure from these procedures may raise individuals’ lifetime risk of developing cancer or other health problems. Here we describe and evaluate a radiation exposure (RE) reduction project developed and implemented at Intermountain Healthcare catheterization laboratories (cath lab).   Hypothesis:  Measuring and reporting RE at the provider and cath lab level for different cardiovascular imaging procedures such as catheter ablations has the potential to help clinicians manage and reduce cumulative RE.   Methods:  In 2011, Intermountain compiled RE, based upon calculating the effective dose (ED) in milliSieverts (mSv) from the measured dose area product (DAP) for electrophysiology studies (EPS) and catheter ablations performed at two Intermountain hospitals. RE variability at the provider and the cath lab level suggested we had an opportunity for improvement. A web-based application was developed for the collection of RE data. Cath lab and provider level RE reports were periodically reviewed during quality improvement meetings. EPS and catheter ablation RE data was combined and a before and after (Sep 2015 – Mar 2016) comparison was performed to evaluate the effectiveness of measuring and reporting RE data.   Results:  The baseline average RE among all 1072 EPS and catheter ablation cases at hospital A was 4.6 mSv while the baseline average RE at hospital B was 38.9 msv (n=897). Average RE after periodic review of radiation reports was 2.1 mSv for hospital A (n=310; p    Conclusion:  Collection, monitoring and reporting of radiation exposure data is an important component of patient safety and has the potential to reduce radiation exposure of fluoroscopic cardiovascular imaging procedures.
Pembrolizumab (pembro) vs standard of care (SOC) for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): Phase 3 KEYNOTE-040 trial
Authors: E.E. Cohen, K.J. Harrington, C. Le Tourneau, J. Dinis, L. Licitra, M-J. Ahn, A. Soria, J-P. Machiels, N. Mach, R. Mehra, B. Burtness, Y. Wang, A.J. Tuozzo, R. Swaby, D. Soulieres
Journal: Annals of Oncology (2017)
Pembrolizumab for patients with PD-L1–positive advanced carcinoid or pancreatic neuroendocrine tumors: Results from the KEYNOTE-028 study
Authors: J.M. Mehnert, H.S. Rugo, B.H. O'Neil, A. Santoro, J.H.M. Schellens, R.B. Cohen, T. Doi, P.A. Ott, M.J. Pishvaian, I. Puzanov, K.L. Aung, C. Hsu, C. Le Tourneau, J-C. Soria, E. Elez, K. Tamura, M. Gould, G. Zhao, K. Stein, S.A. Piha-Paul
Journal: Annals of Oncology (2017)
Dons de sang en Allemagne en 2000-2002 : le risque de transmission virale et l’impact du dépistage génomique viral (DGV)
Authors: Ruth Offergeld, D Faensen, S Ritter, O Hamouda
Journal: Eurosurveillance (2005)

En Allemagne, les dons de sang et de plasma sont recueillis par plusieurs organismes, notamment la Croix-Rouge allemande, les services de transfusion publics et hospitaliers, les centres de transfusion prives, les etablissements commerciaux de dons de sang et les services de transfusion de l’armee. Chaque trimestre, les centres de transfusion doivent declarer au Robert Koch Institute, les donnees concernant les marqueurs d’infection afin de disposer des donnees epidemiologiques precises et mises a jour. La prevalence et l’incidence des infections virales importantes sont faibles dans la population des donneurs de sang en Allemagne, avec une tendance a la baisse depuis 1997 pour les infections de l’hepatite C, que ce soit chez les donneurs connus ou les nouveaux donneurs. La mise en place du depistage genomique viral (DGV) pour le virus de l’hepatite C (VHC), obligatoire depuis 1999, a considerablement ameliore la securite virale des produits sanguins. Pour le VIH, le DGV est devenu obligatoire en 2004, mais etait utilise avant cette date sur la base du volontarat dans la plupart des services de transfusion sanguine. Le benefice potentiel du DGV en minipool n’est pas evident dans le cas du virus de l’hepatite B (VHB) car les porteurs chroniques avec un taux viral tres faible pourraient faire un don sans etre identifies. Le risque residuel infectieux, durant la fenetre serologique, d’un don entrant dans un pool de sang peut etre estime par la formule mathematique suivante : taux d’incidence multiplie par le nombre de jours au cours desquels une infection peut etre presente mais non decelable – soit la duree de la fenetre serologique. En 2001/2002, sans le DGV, le risque d’une infection non detectee etait estime a 1 pour 2 770 000 pour le VIH, 1 pour 670 000 pour le VHC et 1 pour 230 000 pour le VHB. Avec le DGV en minipool, ce risque est de 1 pour 5 540 000 pour le VIH, 1 pour 4 400 000 pour le VHC et 1 pour 620 000 pour le VHB. Ces resultats montrent l’interet du DGV pour la reduction du risque infectieux, deja tres faible, des dons de sang.
Epidemia di infezioni da Clostridium histolyticum in soggetti che assumono droghe per via endovenosa in Inghilterra e Scozia
Authors: J S Brazier, M Gal, V Hall, T E Morris
Journal: Eurosurveillance (2004)

Le infezioni clostridiali in soggetti che assumono droghe per via endovenosa rappresentano nel Regno Unito un fenomeno relativamente nuovo evidenziatosi nel 2000, quando furono registrati casi di gravi infezioni e decessi determinati dal Clostridium novyi. Nel periodo che va da dicembre del 2003 ad aprile del 2004, l'Anaerobe Reference Laboratory ha ricevuto da nove diversi ospedali in Inghilterra e Scozia dodici segnalazioni di un isolato estremamente raro, il Clostridium histolyticum, responsabile di infezione in soggetti che assumevano droghe per via endovenosa. La tipizzazione molecolare di questi isolati con due metodi differenti, l'elettroforesi su gel a campo pulsante e la ribotipizzazione mediante PCR, ha messo in evidenza che gli isolati sono indistinguibili e hanno un'origine comune, molto probabilmente un lotto di eroina che e stato recentemente distribuito in tutto il Regno Unito.
Multi-gene panels: new clinical experience in hereditary breast and ovarian cancer
Authors: T. Ramon y Cajal, A. Lasa, G. Llort, C. Lopez, C. Yagüe, M. Cornet, A. Gisbert, D. Fisas, N. Calvo, A. Vethencourt, A. Barba, S. Quero, E. Martinez, I. Hernan, A. Ruiz, A. Arcusa, E. Saigi, A. Barnadas, J. Surralles
Journal: Annals of Oncology (2017)
Safety, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of PF 06801591, an anti-PD1 antibody administered intravenously (IV) or subcutaneously (SC)
Authors: S. Hu-Lieskovan, M. Johnson, F.S. Braiteh, J. Grilley-Olson, J. Chou, J. Davda, B. Jin, A. Forgie, D. Rassam, S. Youssef
Journal: Annals of Oncology (2017)
Abstract 19800: 18F-FDG PET/CT in the Diagnosis and Management of Continuous Flow Left Ventricular Assist Device Infections: The Rotterdam Experience
Authors: Sakir Akin, Rahat Muslem, Alina A Constantinescu, Olivier C Manintveld, Ozcan Birim, Jasper J Brugts, Alexander P Maat, Alida C Fröberg, Ad J Bogers, Kadir Caliskan
Journal: Circulation (2016)

Introduction:  Infections in left ventricular assist devices (LVAD’s) are associated with high mortality and morbidity. Unfortunately, differentiating between deep and superficial infections could be very cumbersome. In this case series, we describe our single center experience using  18 F-FDG PET/CT in the diagnosis and management of LVAD infections.   Methods:  Between 2011 and 2016, we reviewed all consecutive HeartMate II (n=51) patients in our tertiary referral center.  18 F-FDG PET/CT was done in 9 patients (7 males; mean age 53 ± 15 years) with suspected LVAD infections.   Results:  The median duration of LVAD support was 134 days [range 24-645 days] before  18 F-FDG PET/CT was performed. The mean age was 54 ± 15 years with 78% males. The primary indications for LVAD implantation were bridge-to-transplant (8/9) and destination therapy (1/9). Nine patients with suspected LVAD infection, either pump or driveline with 33% has positive blood cultures, 44 % had positive wound cultures. In 33% we performed the  18 F-FDG PET/CT at short term (within 90 days postoperative) and in 67% the  18 F-FDG PET/CT was performed at longer term follow-up. In all,  18 F-FDG PET/CT was performed to establish and determine the extent of LVAD infections, within 67% there were unexpected extensive deep infections. In 2/9 patients,  18 F-FDG PET/CT could rule out any LVAD infections, both very early (24 and 29 days) in the postoperative phase.   Conclusions:  In this case series of nine LVAD patients,  18 F-FDG PET/CT imaging differentiated excellently between deep and superficial LVAD infections as earlier as 3 weeks post-implantation.
Dihydroergotamine mesylate-loaded dissolving microneedle patch made of polyvinylpyrrolidone for management of acute migraine therapy
Authors: Cetin Tas, Jessica C. Joyce, Hiep X. Nguyen, Padmanabhan Eangoor, Jennifer S. Knaack, Ajay K. Banga, Mark R. Prausnitz
Journal: Journal of Controlled Release (2017)
Circumferential rectal laterally spreading tumor resected by endoscopic submucosal dissection in a Western center
Authors: José Rodrigues, Pedro Barreiro, Joana Carmo, Lídia Ramos, Cristina Chagas
Journal: Endoscopy (2017)

A 78-year-old patient without relevant past medical history underwent colonoscopy for chronic diarrhea. Examination identified a laterally spreading tumor (LST), mixed-granular-type (nodules up to 1 cm) in the rectum, from the pectin line to the rectosigmoid transition. The LST covered 100 % of the circumference of this segment ([Fig. 1]). Endoscopic evaluation was compatible with an adenomatous lesion with preserved pit pattern (Kudo IIIL/IV classification), without unequivocal endoscopic suspicion of invasive lesion (NICE 2; JNET 2B). After multidisciplinary evaluation, endoscopic resection by endoscopic submucosal dissection (ESD) was decided.
NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR
Authors: Hui Feng, Erik M Lenarcic, Daisuke Yamane, Eliane Wauthier, Jinyao Mo, Haitao Guo, David R McGivern, Olga González-López, Ichiro Misumi, Lola M Reid, Jason K Whitmire, Jenny P-Y Ting, Joseph A Duncan, Nathaniel J Moorman, Stanley M Lemon
Journal: Nature Immunology (2017)
ULTRA clinical trial: Prospective comparative clinical outcome analysis of three different RAS/BRAF sensitivity mutational cut-offs. A Phase II study of the Spanish TTD Group
Authors: R. Salazar, D. Azuara, J.M. Viéitez, D. Paez, C. Santos, E. Falcó, E. Elez, C. López López, M. Valladares-Ayerbes, L. Robles, P. Garcia-Alfonso, C. Buges, G. Duran Ogaya, M.A. Salud Salvia, V. Navarro, G. Capella, E. Aranda Aguilar
Journal: Annals of Oncology (2017)
Stem Cell Secretome and Its Effect on Cellular Mechanisms Relevant to Wound Healing
Authors: Se-Ra Park, Jae-Wan Kim, Hee-Sook Jun, Joo Young Roh, Hwa-Yong Lee, In-Sun Hong
Journal: Molecular Therapy (2017)

Stem cells introduced to site of injury primarily act via indirect paracrine effects rather than direct cell replacement of damaged cells. This gives rise to understanding the stem cell secretome. In this study, in vitro studies demonstrate that the secretome activates the PI3K/Akt or FAK/ERK1/2 signaling cascades and subsequently enhances the proliferative and migratory abilities of various types of skin cells, such as fibroblasts, keratinocytes, and vascular epithelial cells, ultimately accelerating wound contraction. Indeed, inhibition of these signaling pathways with synthetic inhibitors resulted in the disruption of secretome-induced beneficial effects on various skin cells. In addition, major components of the stem cell secretome (EGF, basic FGF, and HGF) may be responsible for the acceleration of wound contraction. Stimulatory effects of these three prominent factors on wound contraction are achieved through the upregulation of PI3K/Akt or FAK/ERK1/2 activity. Overall, we lay the rationale for using the stem cell secretome in promoting wound contraction. In vivo wound healing studies are warranted to test the significance of our in vitro findings.
La rete spagnola di sorveglianza della multiresistenza ai farmaci della tubercolosi
Authors: S Samper, M. J. Iglesias, O Tello
Journal: Eurosurveillance (2000)

In Spagna, e stata istituita dal gennaio 1998 una rete di sorveglianza per monitorare la diffusione della tubercolosi multiresistente ai farmaci (MDR-TB). Si basa sulla tipizzazione genomica e vi partecipano circa il 90% dei laboratori del servizio sanitario nazionale. Circa il 30% dei 94 pazienti multiresistenti partecipanti allo studio del 1998, mostravano un identico profilo di tipizzazione. Il 20% dei pazienti si sono reinfettati con HIV, un rapporto simile a quello osservato nei pazienti con tubercolosi sensibile ai farmaci. Lo scopo della rete e organizzare un sistema di allerta precoce per MDR-TB a livello nazionale.
The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies: a review
Authors: Shirley Yin-Yu Pang, Kay-Cheong Teo, Jacob Shujui Hsu, Richard Shek-Kwan Chang, Miaoxin Li, Pak-Chung Sham, Shu-Leong Ho
Journal: Translational Neurodegeneration (2017)

The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping symptoms. It does not take into account the disease etiology or the highly variable clinical course even amongst patients diagnosed with the same disorder. The advent of next generation sequencing (NGS) has allowed for a system-wide, unbiased approach to identify all gene variants in the genome simultaneously. With the plethora of new genes being identified, genetic rather than phenotype-based classification of Mendelian diseases such as spinocerebellar ataxia (SCA), hereditary spastic paraplegia (HSP) and Charcot-Marie-Tooth disease (CMT) has become widely accepted. It has also become clear that gene variants play a role in common and predominantly sporadic neurodegenerative diseases such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). The observation of pleiotropy has emerged, with mutations in the same gene giving rise to diverse phenotypes, which further increases the complexity of phenotype-genotype correlation. Possible mechanisms of pleiotropy include different downstream effects of different mutations in the same gene, presence of modifier genes, and oligogenic inheritance. Future directions include development of bioinformatics tools and establishment of more extensive public genotype/phenotype databases to better distinguish deleterious gene variants from benign polymorphisms, translation of genetic findings into pathogenic mechanisms through in-vitro and in-vivo studies, and ultimately finding disease-modifying therapies for neurodegenerative disorders.
Death by Gun Violence—A Public Health Crisis
Authors: Howard Bauchner, Frederick P. Rivara, Robert O. Bonow, Neil M. Bressler, Mary L. (Nora) Disis, Stephan Heckers, S. Andrew Josephson, Melina R. Kibbe, Jay F. Piccirillo, Rita F. Redberg, John S. Rhee, June K. Robinson
Journal: JAMA Surgery (2017)

The shooting in Las Vegas, Nevada, that left 59 people dead, 10 times that number wounded, and thousands of people with the psychological distress from being present at the scene during and after the massacre has once again raised the issue of what we as a nation can and should do about guns.The solution lies in not just focusing on Las Vegas and the hundreds of other mass shootings that have occurred in the United States in the last 14 months, but rather to underscore that on average almost 100 people die each day in the United States from gun violence.The 36 252 deaths from firearms in the United States in 2015 1 exceeded the number of deaths from motor vehicle traffic crashes that year (36 161). 1 That same year, the US Centers for Disease Control and Prevention reported that 5 people died from terrorism.Since 1968, more individuals in the United States have died from gun violence than in battle during all the wars the country has fought since its inception. 2uns do not make individuals, their families, or homes safer and they result in far more deaths to loved ones than to an intruder intending to cause harm. 3Often forgotten is that 60.7% of the gun deaths in 2015 in the United States were suicides. 1Means used to attempt suicide matter; guns will result in suicidal deaths well over 90% of the time, whereas ingestion of pills or wrist cutting will be unsuccessful more than 90% of the time.The majority of people who try to commit suicide but survive the attempt will not go on to die from suicide 4 ; if the attempt is with a gun, there will be no second chance at life.The journals of the JAMA Network are dedicated to improving the health of people across the globe.We do so by addressing the most important public health problems harming people and publishing the best science that can be done.The journals have published important work on gun violence; in the past year this has included studies on differences in gun use during terrorist attacks in the United States compared with other countries, 5 the effect of exposure to gun violence in the media on children's interest in real guns,
GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8
Authors: Michal P. Wandel, Claudio Pathe, Emma I. Werner, Cara J. Ellison, Keith B. Boyle, Alexander von der Malsburg, John Rohde, Felix Randow
Journal: Cell Host & Microbe (2017)

Interferon exposure boosts cell-autonomous immunity for more efficient pathogen control. But how interferon-enhanced immunity protects the cytosol against bacteria and how professionally cytosol-dwelling bacteria avoid clearance are insufficiently understood. Here we demonstrate that the interferon-induced GTPase family of guanylate-binding proteins (GBPs) coats Shigella flexneri in a hierarchical manner reliant on GBP1. GBPs inhibit actin-dependent motility and cell-to-cell spread of bacteria but are antagonized by IpaH9.8, a bacterial ubiquitin ligase secreted into the host cytosol. IpaH9.8 ubiquitylates GBP1, GBP2, and GBP4 to cause the proteasome-dependent destruction of existing GBP coats. This ubiquitin coating of Shigella favors the pathogen as it liberates bacteria from GBP encapsulation to resume actin-mediated motility and cell-to-cell spread. We conclude that an important function of GBP recruitment to S. flexneri is to prevent the spread of infection to neighboring cells while IpaH9.8 helps bacterial propagation by counteracting GBP-dependent cell-autonomous immunity.
GW28-e0755 Non-Invasive measurement of the pulmonary artery wedge pressure and the left ventricular end diastolic pressure
Authors: Thach Nguyen, Khanh Duong, Bui Pham Thai Hoa, Nguyen Minh Tri Nhan, Le Thi Thuy Linh, Gianluca Rigatelli
Journal: Journal of the American College of Cardiology (2017)
Precision Trial Designer: A computational tool to assist in the design of genomics-driven trials in oncology
Authors: L. Mazzarella, G. Melloni, A. Guida, G. Curigliano, E. Botteri, A. Esposito, M. Kamal, C. Le Tourneau, A. Magi, L. Riva, P. Pelicci
Journal: Annals of Oncology (2017)
Manufacture of Platelets from Human Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells: Functional Comparison to Concentrate Platelets
Authors: Keiichi Tozawa, Yukako Ono-Uruga, Masaki Yazawa, Taisuke Mori, Noriko Takizawa, Mitsuru Murata, Shinichiro Okamoto, Yasuo Ikeda, Yumiko Matsubara
Journal: Blood (2016)
Psychiatric adverse events during treatment with brodalumab: Analysis of psoriasis clinical trials
Authors: Mark G. Lebwohl, Kim A. Papp, Lauren B. Marangell, John Koo, Andrew Blauvelt, Melinda Gooderham, Jashin J. Wu, Shipra Rastogi, Susan Harris, Radhakrishnan Pillai, Robert J. Israel
Journal: Journal of the American Academy of Dermatology (2017)
Loading‐Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late‐Stage Osteoarthritis
Authors: Haoruo Jia, Xiaoyuan Ma, Yulong Wei, Wei Tong, Robert J. Tower, Abhishek Chandra, Luqiang Wang, Zeyang Sun, Zhaochun Yang, Farid Badar, Kairui Zhang, Wei‐Ju Tseng, Ina Kramer, Michaela Kneissel, Yang Xia, X. Sherry Liu, James H. C. Wang, Lin Han, Motomi Enomoto‐Iwamoto, Ling Qin
Journal: Arthritis & Rheumatology (2017)

To establish an unbiased, 3-dimensional (3-D) approach that quantifies subchondral bone plate (SBP) changes in mouse joints, and to investigate the mechanism that mediates SBP sclerosis at a late stage of osteoarthritis (OA).A new micro-computed tomography (micro-CT) protocol was developed to characterize the entire thickness of the SBP in the distal femur of a normal mouse knee. Four mouse models of severe joint OA were generated: cartilage-specific Egfr-knockout (Egfr-CKO) mice at 2 months after surgical destabilization of the medial meniscus (DMM), Egfr-CKO mice with aging-related spontaneous OA, wild-type (WT) mice at 10 months after DMM, and WT mice at 14 weeks after DMM plus hemisectomy of the meniscus (DMMH) surgery. As an additional model, mice with knockout of the sclerostin gene (Sost-KO) were subjected to DMMH surgery. Knee joints were examined by micro-CT, histology, and immunohistochemical analyses.Examination of the mouse distal femur by 3-D micro-CT revealed a positive correlation between SBP thickness and the loading status in normal knees. In all 4 mouse models of late-stage OA, SBP sclerosis was restricted to the areas under severely eroded articular cartilage. This was accompanied by elevated bone formation at the bone marrow side of the SBP and a drastic reduction in the levels of sclerostin in osteocytes within the SBP. Unlike in WT mice, no further increase in the thickness of the SBP was observed in response to DMMH in Sost-KO mice.Since focal stress on the SBP underlying sites of cartilage damage increases during late stages of OA, these findings establish mechanical loading-induced attenuation of sclerostin expression and elevation of bone formation along the SBP surface as the major mechanisms characterizing subchondral bone phenotypes associated with severe late-stage OA in mice.
Frequency of p190 and p210 BCR-ABL Fusions Genes in Acute Lymphoblastic Leukemia in a Long Group of Adults and Childhood
Authors: Rosa Maria Arana-Trejo, Gregorio Ignacio, Raquel Amador-Sánchez, Jorge Cruz-Rico, Maria-Paula Hernández, Israel Saldivar, Yolanda Lugo, Juan-Carlos Solís-Poblano, Oscar Pérez, Monica Tejeda, Alberto Artristian, Luis Solís-Anaya
Journal: Blood (2016)