tbuckley/cabot-search huggingface dataset:
Abstract 12846: Resuscitation of Out-of-Hospital Cardiac Arrest Without CPR: The 13-Year Experience of Progetto Vita
Authors: Alessandro Capucci, Daniela Aschieri, Federico Guerra, Valentina Pelizzoni, Stefano Nani, Giovanni Q Villani, Gust H Bardy
Journal: Circulation (2015)

Introduction: Cardiopulmonary resuscitation (CPR) currently represents standard of care in out-of-hospital cardiac arrest (OOHCA) despite the demonstration of its many side effects. To date, CPR has never been tested in a randomized, prospective clinical trial against an automated external defibrillator (AED) quick deployment, as such a trial is considered impossible for ethical reasons. Nevertheless, insights on the effective role of CPR when an AED is quickly available can be provided from the Progetto Vita of Piacenza, Italy: the first early defibrillation project established in Europe. Hypothesis: To compare differences in 13-year survival between OOHCA victims rescued by standard care and patients rescued by AED-only trained responders. Methods: Prospective, non-randomized parallel study comparing mortality when rescuers only used automated external defibrillators (AEDs) and did not perform CPR with mortality from the standard Emergency Medical Services (EMS) response, including CPR. Survival was followed over 13 years, from June 2001 to July 2014. Results: In 3366 OOHCAs, survival to hospital discharge occurred in 39 of the 95 patients treated with an AED only and in 193 of the 3271 patients treated by standard EMS (41.4% vs. 5.9%; p&lt;0.001) The Kaplan Meier estimates of survival after 13-years follow-up are 31.8% when AEDs only were used versus 2.4% for standard EMS response. Estimates of survival also are significantly better for Progetto Vita when survival was stratified by gender and location of cardiac arrest. Presence of a shockable rhythm at rescuers arrival was associated with a 16.8-fold increased chance of survival to discharge. Progetto Vita intervention was independently associated with a 2.8-fold increased chance of survival to discharge, regardless of minutes from dispatch to arrival, cardiac arrest location, rhythm presentation, and age. Conclusions: Progetto Vita demonstrates excellent long-term survival from out-of-hospital cardiac arrest without CPR use compared with standard resuscitation. The findings from the present study could provide solid "real-world" evidence for the broadscale dissemination of AEDs quickly available to layperson rescuers.
Time trends in overall survival (OS) gain in advanced non-small-cell lung cancer (NSCLC).
Authors: Everardo D. Saad, Marc E. Buyse, Jacek Jassem
Journal: Journal of Clinical Oncology (2013)

e19144 Background: There is an ongoing debate about the adequacy of OS as primary endpoint (PEP) in phase III trials in various tumor types, including NSCLC (Soria Ann Oncol 2010). Moreover, median OS and post-progression survival are increasing in NSCLC (Hotta PLoS One 2011 and Hayashi Ann Oncol 2012). We assessed the frequency and time trends in OS gain in recent trials. Methods: We searched PubMed for phase III trials in advanced NSCLC published between January 1998 and December 2011 in 13 leading journals. The PEP was the endpoint stated explicitly, used for N calculation, or listed first. Gain in OS was ascertained when there were significant differences in any pairwise comparison on OS following the original authors’ definitions. Results: We retrieved 148 trials that enrolled a total of 70,716 patients in 325 trial arms. The median number of patients per arm was larger for the 2005-2011 period than for the 1998-2004 period (207 vs 150; P&lt;0.01). OS was used as PEP alone in 99 trials, and as one of the co-primary endpoints in 3 trials (the PEP could not be ascertained for one trial). There was no trend regarding the use of OS as PEP in the two periods compared, either overall (P=0.44) or in first line (P=0.41). Gain in OS according to trial features is shown in the Table. Conclusions: Significant gains in OS appear to decrease along the years, despite the growth in size of NSCLC trials and the continued use of OS as PEP. [Table: see text]
Retention, engagement, and adherence to pre-exposure prophylaxis for men who have sex with men and transgender women in PrEP Brasil: 48 week results of a demonstration study
Authors: Beatriz Grinsztejn, Brenda Hoagland, Ronaldo I Moreira, Esper G Kallas, Jose V Madruga, Silvia Goulart, Iuri C Leite, Lucilene Freitas, Luana M S Martins, Thiago S Torres, Ricardo Vasconcelos, Raquel B De Boni, Peter L Anderson, Albert Liu, Paula M Luz, Valdiléa G Veloso, Valvina Madeira Adão, Paulo R Alencastro, Ana Paula Amaral, Toni Araújo, Denivalda Araújo, Daniel Artur Bertevello, Cristiane Bressani, Sandra Wagner Cardoso, Robério Alves Carneiro, Renan Carvalho, Natália Barros Cerqueira, Leandro Cocolato, Marcus Vinícius M. da Costa, Rosângela Vitória Soares da Silva, Maria Cândida de Souza Dantas, Cristiane Regina V de Castro, Karine Milani da Silva Dias, Camila Sunaitis Donini, Aline Tatiane Lumertz dos Anjos, Arlene Augusta dos Santos, Rita de Cássia Elias Estrela, Nilo Martinez Fernandes, Lilian Ferrari, Josias Freitas, Tatiane da Silva Gomes, Maura L Gonzalez, Raphaela Goulart, José Roberto Granjeiro, Marcus Vinicius G Lacerda, Priscilla de Lima e Menezes, Gustavo Mizuno, Laylla Monteiro, Issler Moraes, Carlos Moreira, Denise Sales Mourão, Zelinda Bartolomei Nakagawa, Sandro Nazer, Maria Angelica Alcalá Neves, Roberta Schiavon Nogueira, Fatuma Odongo, Tiago Porto, Gladys Prado, Marcia Puerro, Gisele N. Reis, Valéria Ribeiro, Charlene Rocha, Camila Rodrigues, Rafael Salles, Mariana Sauer, Taís Sousa, Celso Oliveira Tavares, Claudia Satiko Tomiyama, Helena Tomiyama, Desirée Vieira, Vinicius Vieira, Larissa Villela, Daniel M. McMahon Waite, Nélio Zuccaro
Journal: The Lancet HIV (2018)
Metabolic and cardiovascular benefits of hydroxychloroquine in patients with rheumatoid arthritis: a systematic review and meta-analysis
Authors: Hui-Zi Li, Xiang-He Xu, Nan Lin, Hua-Ding Lu
Journal: Annals of the Rheumatic Diseases (2018)

With great interest, we read the paper recently published in the  Annals of the Rheumatic Diseases titled ‘Metabolic and cardiovascular benefits of hydroxychloroquine in patients with rheumatoid arthritis(RA): a systematic review and meta-analysis’.1 In the study, the authors revealed that hydroxychloroquine may benefit the metabolic profile and to a lesser extent cardiovascular events in patients with RA. We congratulate and applaud their significant work for clinical practice, but there are some worthwhile issues that need to be further explored.

First, the current meta-analysis was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis, but the protocol, which should have been predefined, was not registered in any platforms, such as the Cochrane Library, PROSPERO (https://www.crd.york.ac.uk/prospero/) and BMJ …
Genome-wide mapping of global-to-local genetic effects on human facial shape
Authors: Peter Claes, Jasmien Roosenboom, Julie D. White, Tomek Swigut, Dzemila Sero, Jiarui Li, Myoung Keun Lee, Arslan Zaidi, Brooke C. Mattern, Corey Liebowitz, Laurel Pearson, Tomás González, Elizabeth J. Leslie, Jenna C. Carlson, Ekaterina Orlova, Paul Suetens, Dirk Vandermeulen, Eleanor Feingold, Mary L. Marazita, John R. Shaffer, Joanna Wysocka, Mark D. Shriver, Seth M. Weinberg
Journal: Nature Genetics (2018)
Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells
Authors: Jiancheng Wang, Xin Liu, Yuan Qiu, Yue Shi, Jianye Cai, Boyan Wang, Xiaoyue Wei, Qiong Ke, Xin Sui, Yi Wang, Yinong Huang, Hongyu Li, Tao Wang, Ren Lin, Qifa Liu, Andy Peng Xiang
Journal: Journal of Hematology & Oncology (2018)

Despite the high cure rate of T cell acute lymphoblastic leukemia (T-ALL), drug resistance to chemotherapy remains a significant clinical problem. Bone marrow mesenchymal stem cells (MSCs) protect leukemic cells from chemotherapy, but the underlying mechanisms are poorly understood. In this study, we aimed to uncover the mechanism of MSC-induced chemoresistance in T-ALL cells, thus providing a promising clinical therapy target.Cell viability was determined using the viability assay kit CCK-8. The mitochondrial ROS levels were detected using the fluorescent probe MitoSOX™ Red, and fluorescence intensity was measured by flow cytometry. In vitro, MSCs and Jurkat cells were cocultured. MSCs were labeled with green fluorescent protein (GFP), and Jurkat cells were labeled with the mitochondria-specific dye MitoTracker Red. Bidirectional mitochondrial transfer was detected by flow cytometry and confocal microscopy. The mechanism of mitochondria transfer was analyzed by inhibitor assays. Transcripts related to Jurkat cell/MSC adhesion in the coculture system were assessed by qRT-PCR. After treatment with a neutralizing antibody against a key adhesion molecule, mitochondria transfer from Jurkat cells to MSCs was again detected by flow cytometry and confocal microscopy. Finally, we verified our findings using human primary T-ALL cells cocultured with MSCs.Chemotherapeutic drugs caused intracellular oxidative stress in Jurkat cells. Jurkat cells transfer mitochondria to MSCs but receive few mitochondria from MSCs, resulting in chemoresistance. This process of mitochondria transfer is mediated by tunneling nanotubes, which are protrusions that extend from the cell membrane . Moreover, we found that most Jurkat cells adhered to MSCs in the coculture system, which was mediated by the adhesion molecule ICAM-1. Treatment with a neutralizing antibody against ICAM-1 led to a decreased number of adhering Jurkat cells, decreased mitochondria transfer, and increased chemotherapy-induced cell death.We show evidence that mitochondria transfer from Jurkat cells to MSCs, which is mediated by cell adhesion, may be a potential therapeutic target for T-ALL treatment.
Shortening the Time to Manufacture CAR+ T Cells with Sleeping Beauty System Supports T-Cell Engraftment and Anti-Tumor Effects in Patients with Refractory CD19+ Tumors
Authors: Partow Kebriaei, Helen Huls, Susan Lynn Neel, Simon Olivares, Aaron F Orozco, Shihuang Su, Sourindra N Maiti, Amy Smith, Elenanor De Groot, Hagop M. Kantarjian, Maro Ohanian, Katy Rezvani, Elizabeth J Shpall, Richard E Champlin, Laurence J N Cooper, Harjeet Singh
Journal: Blood (2017)
Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy
Authors: Jeffrey R. Ashton, Katherine D. Castle, Yi Qi, David G. Kirsch, Jennifer L. West, Cristian T. Badea
Journal: Theranostics (2018)

Gold nanoparticles (AuNPs) are emerging as promising agents for both cancer therapy and computed tomography (CT) imaging.AuNPs absorb x-rays and subsequently release low-energy, short-range photoelectrons during external beam radiation therapy (RT), increasing the local radiation dose.When AuNPs are near tumor vasculature, the additional radiation dose can lead to increased vascular permeability.This work focuses on understanding how tumor vascular permeability is influenced by AuNP-augmented RT, and how this effect can be used to improve the delivery of nanoparticle chemotherapeutics.Methods: Dual-energy CT was used to quantify the accumulation of both liposomal iodine and AuNPs in tumors following AuNP-augmented RT in a mouse model of primary soft tissue sarcoma.Mice were injected with non-targeted AuNPs, RGD-functionalized AuNPs (vascular targeting), or no AuNPs, after which they were treated with varying doses of RT.The mice were injected with either liposomal iodine (for the imaging study) or liposomal doxorubicin (for the treatment study) 24 hours after RT.Increased tumor liposome accumulation was assessed by dual-energy CT (iodine) or by tracking tumor treatment response (doxorubicin).Results: A significant increase in vascular permeability was observed for all groups after 20 Gy RT, for the targeted and non-targeted AuNP groups after 10 Gy RT, and for the vascular-targeted AuNP group after 5 Gy RT.Combining targeted AuNPs with 5 Gy RT and liposomal doxorubicin led to a significant tumor growth delay (tumor doubling time ~ 8 days) compared to AuNP-augmented RT or chemotherapy alone (tumor doubling time ~3-4 days).Conclusions: The addition of vascular-targeted AuNPs significantly improved the treatment effect of liposomal doxorubicin after RT, consistent with the increased liposome accumulation observed in tumors in the imaging study.Using this approach with a liposomal drug delivery system can increase specific tumor delivery of chemotherapeutics, which has the potential to significantly improve tumor response and reduce the side effects of both RT and chemotherapy.
Validation of The Asthma Adherence Management Model (AAMM)
Authors: Andrew G. Weinstein, Deborah A. Gentile, Anil Singh, David P. Skoner, Jennifer Maiolo, Rihab Sharara, Kiet Ma, Tariq Cheema, Erica Butler, Allison Kong
Journal: Journal of Allergy and Clinical Immunology (2018)
Analysis of airway pathology in COPD using a combination of computed tomography, micro-computed tomography and histology
Authors: Naoya Tanabe, Dragoş M. Vasilescu, Miranda Kirby, Harvey O. Coxson, Stijn E. Verleden, Bart M. Vanaudenaerde, Daisuke Kinose, Yasutaka Nakano, Peter D. Paré, James C. Hogg
Journal: European Respiratory Journal (2018)

The small conducting airways are the major site of obstruction in chronic obstructive pulmonary disease (COPD). This study examined small airway pathology using a novel combination of multidetector row computed tomography (MDCT), micro-computed tomography (microCT) and histology. Airway branches visible on specimen MDCT were counted and the dimensions of the third- to fifth-generation airways were computed, while the terminal bronchioles (designated TB), preterminal bronchioles (TB-1) and pre-preterminal bronchioles (TB-2) were examined with microCT and histology in eight explanted lungs with end-stage COPD and seven unused donor lungs that served as controls. On MDCT, COPD lungs showed a decrease in the number of 2–2.5 mm diameter airways and the lumen area of fifth-generation airways, while on microCT there was a reduction in the number of terminal bronchioles as well as a decrease in the luminal areas, wall volumes and alveolar attachments to the walls of TB, TB-1 and TB-2 bronchioles. The combination of microCT and histology showed increased B-cell infiltration into the walls of TB-1 and TB-2 bronchioles, and this change was correlated with a reduced number of alveolar attachments in COPD. Small airways disease extends from 2 mm diameter airways to the terminal bronchioles in COPD. Destruction of alveolar attachments may be driven by a B-cell-mediated immune response in the preterminal bronchioles.
Identification of a novel predictive genomic biomarker for response to combination bevacizumab in metastatic colorectal cancer (mCRC).
Authors: Annette T. Byrne, Dominiek Smeets, Ian S. Miller, Sudipto Das, Bram Boeckx, Jeroen Depreeuw, Timo Gaiser, Johannes Betge, Ana Barat, Verena Murphy, Bruce Moran, Bozena Fender, Rut Klinger, Matthias Philip Ebert, Nicole C.T. van Grieken, Bauke Ylstra, William M. Gallagher, Jochen Prehn, Darran O'Connor, Diether Lambrechts
Journal: Journal of Clinical Oncology (2017)

3580 Background: Somatic copy number alterations (SCNA) are genomic alterations evident in cancers including mCRC. These alterations support biomarker discovery, allowing identification of variants that can be used to predict response to therapy. Herein, we studied the impact of SCNAs on mCRC patient response to bevacizumab (BVZ). Methods: SCNA data was assembled from mCRC tumors in the TCGA cohort (n = 676), from the CAIRO 2 study [n = 143] and from the ANGIOPREDICT cohort (n = 258) [Betge et al. Digestion 2016 94(3):129-137]. GISTIC v2.0 was used to identify the most frequent and overrepresented chromosomal aberrations. A region was considered deleted if the logR value was &lt; 0.1 and amplified when the logR was &gt; 0.1. A cutoff q-value of 0.25 was used to select significantly overrepresented SCNAs. To further explore the impact of new ANGIOPREDICT clusters and consensus molecular subtypes (CMS), [Guinney J et al Nat Med. 2015 21(11):1350-6], a panel of seven xenografts representing each CMS subtype was treated with FOLFOX (40mg/kg 5-FU, 13.4mg/kg folinic acid &amp; 2.4mg/kg oxaliplatin) + B20 antibody (mouse avastin, 10mg/kg) for 4 weeks. Results: Unsupervised hierarchical clustering classified all 1077 tumors into 3 consensus SCNA subgroups termed ‘ANGIOPREDICT’ clusters 1-3. Concordance between CMS and ANGIOPREDICT clusters was evident: CMS1 - Cluster 1 78%, CMS3 - Cluster 1 50%. CMS2 - Cluster 2/3 92% and CMS4 - Cluster 2/3 84%. Tumors with intermediate or high copy number instability (ANGIOPREDICT cluster 2 &amp; 3) showed improved progression free survival (PFS): 369d vs. 227d p = 1.36e -7 ) whereas tumors with low copy number alterations displayed a poor response to BVZ therapy (PFS: 147d vs 152d p = 0.906). Xenografts corresponding to CMS 2&amp;4/ ANGIOPREDICT cluster 2-3 showed improved response to FOLFOX + B20 therapy and increased PFS (p &lt; 0.001) vs. CMS1&amp;3/ ANGIOPREDICT cluster 1. Conclusions: For the first time, in a large test and validation cohort including retrospectively collected and randomized controlled trial patient samples, we have identified a predictive genomic biomarker for BVZ therapy in mCRC. We have further demonstrated the utility of CMS subtyping to stratify patients to BVZ .
IgE Sensitization to the Food Allergen Galactose-α-1,3-Galactose is Associated with Coronary Atherosclerosis
Authors: Jeffrey M. Wilson, Anh T. Nguyen, Alexander J. Schuyler, Scott P. Commins, Angela M. Taylor, Thomas A.E. Platts-Mills, Coleen A. McNamara
Journal: Journal of Allergy and Clinical Immunology (2018)
Enterovirus D68 and acute flaccid myelitis—evaluating the evidence for causality
Authors: Kevin Messacar, Edwin J Asturias, Alison M Hixon, Coretta Van Leer-Buter, Hubert G M Niesters, Kenneth L Tyler, Mark J Abzug, Samuel R Dominguez
Journal: The Lancet Infectious Diseases (2018)
Sliding hip screw versus cannulated cancellous screws for fixation of femoral neck fracture in adults: A systematic review
Authors: Jian-xiong Ma, Ming-jie Kuang, Fei Xing, Yun-long Zhao, Heng-ting Chen, Lu-kai Zhang, Zheng-rui Fan, Chao Han, Xin-long Ma
Journal: International Journal of Surgery (2018)
HIV latency in isolated patient CD4 <sup>+</sup> T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing
Authors: Steven A. Yukl, Philipp Kaiser, Peggy Kim, Sushama Telwatte, Sunil K. Joshi, Mai Vu, Harry Lampiris, Joseph K. Wong
Journal: Science Translational Medicine (2018)

HIV latency may not be governed by a lack of transcriptional initiation, but rather by blocks to RNA elongation, polyadenylation, and splicing.
Technological Advances, Biologic Rationales, and the Associated Success of Chemotherapy With Hyperthermia in Improved Outcomes in Patients With Sarcoma
Authors: Mark W. Dewhirst, David Kirsch
Journal: JAMA Oncology (2018)

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Le traitement des rectites radiques Hémorragiques par la coagulation au plasma d'argon
Authors: F Miyabe, F Rouibaa, S Berrag, F Nejjari, S Jamal, M Tamzaourte, A Aourarh
Journal: Endoscopy (2018)

La rectite radique chronique est une complication de la radiothérapie pour des tumeurs pelviennes malignes. Une complication fréquente et parfois grave est la rectite radique hémorragique. La Coagulation au Plasma d'Argon (CPA) est une technique d'électrocoagulation qui semble être une alternative efficace et peu coûteuse.
Epidemiology of Adult <i>DSM-5</i> Major Depressive Disorder and Its Specifiers in the United States
Authors: Deborah S. Hasin, Aaron L. Sarvet, Jacquelyn L. Meyers, Tulshi D. Saha, W. June Ruan, Malka Stohl, Bridget F. Grant
Journal: JAMA Psychiatry (2018)

No US national data are available on the prevalence and correlates of DSM-5-defined major depressive disorder (MDD) or on MDD specifiers as defined in DSM-5.To present current nationally representative findings on the prevalence, correlates, psychiatric comorbidity, functioning, and treatment of DSM-5 MDD and initial information on the prevalence, severity, and treatment of DSM-5 MDD severity, anxious/distressed specifier, and mixed-features specifier, as well as cases that would have been characterized as bereavement in DSM-IV.In-person interviews with a representative sample of US noninstitutionalized civilian adults (≥18 years) (n = 36 309) who participated in the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions III (NESARC-III). Data were collected from April 2012 to June 2013 and were analyzed in 2016-2017.Prevalence of DSM-5 MDD and the DSM-5 specifiers. Odds ratios (ORs), adjusted ORs (aORs), and 95% CIs indicated associations with demographic characteristics and other psychiatric disorders.Of the 36 309 adult participants in NESARC-III, 12-month and lifetime prevalences of MDD were 10.4% and 20.6%, respectively. Odds of 12-month MDD were significantly lower in men (OR, 0.5; 95% CI, 0.46-0.55) and in African American (OR, 0.6; 95% CI, 0.54-0.68), Asian/Pacific Islander (OR, 0.6; 95% CI, 0.45-0.67), and Hispanic (OR, 0.7; 95% CI, 0.62-0.78) adults than in white adults and were higher in younger adults (age range, 18-29 years; OR, 3.0; 95% CI, 2.48-3.55) and those with low incomes ($19 999 or less; OR, 1.7; 95% CI, 1.49-2.04). Associations of MDD with psychiatric disorders ranged from an aOR of 2.1 (95% CI, 1.84-2.35) for specific phobia to an aOR of 5.7 (95% CI, 4.98-6.50) for generalized anxiety disorder. Associations of MDD with substance use disorders ranged from an aOR of 1.8 (95% CI, 1.63-2.01) for alcohol to an aOR of 3.0 (95% CI, 2.57-3.55) for any drug. Most lifetime MDD cases were moderate (39.7%) or severe (49.5%). Almost 70% with lifetime MDD had some type of treatment. Functioning among those with severe MDD was approximately 1 SD below the national mean. Among 12.9% of those with lifetime MDD, all episodes occurred just after the death of someone close and lasted less than 2 months. The anxious/distressed specifier characterized 74.6% of MDD cases, and the mixed-features specifier characterized 15.5%. Controlling for severity, both specifiers were associated with early onset, poor course and functioning, and suicidality.Among US adults, DSM-5 MDD is highly prevalent, comorbid, and disabling. While most cases received some treatment, a substantial minority did not. Much remains to be learned about the DSM-5 MDD specifiers in the general population.