tbuckley/cabot-search huggingface dataset:
INCREASED RESISTANCE AGAINST CIPROFLOXACINE AND METRONIDAZOLE IN CHOLANGITIS
Authors: D Illés, L Czakó
Journal: Endoscopy (2018)

Microbiological tests of bile samples collected during ERCP performed in patients with cholestasis and cholangitis were analysed at the First Department of Internal Medicine, University of Szeged, in 2006 and in 2016 as follows: rate of positive samples, type of pathogens, AB-resistance and efficacy of empirical AB treatment.
EUS (ENDOSCOPIC ULTRASOUND) – GUIDED CELIAC PLEXUS BLOCK (CPB) FOR PANCREATO-BILLIARY PAIN
Authors: M Kasi, K Ragunath, J Ortiz, H Tan, A Akinbamijo, P Ayuen, M James, G Aithal, S Venkatachalapathy
Journal: Endoscopy (2018)

The efficacy of EUS-CPB in the pain management of pancreatic cancer and chronic pancreatitis is 72% and 51% respectively. The efficacy of EUS-CPB in pancreato-biliary pain but with normal investigations has not yet been reported. We report the results of a single centre retrospective observational study on the efficacy and safety of EUS-CPB in the above condition.
‘What’s my risk of sustaining an ACL injury while playing football (soccer)?’ A systematic review with meta-analysis
Authors: Alicia M Montalvo, Daniel K Schneider, Paula L Silva, Laura Yut, Kate E Webster, Michael A Riley, Adam W Kiefer, Jennifer L Doherty-Restrepo, Gregory D Myer
Journal: British Journal of Sports Medicine (2018)

Objective To estimate the incidence proportion (IP) and incidence rate (IR) of ACL injury in football players. Design Systematic review with meta-analysis. Data sources PubMed, CINAHL and SPORTDiscus electronic databases were searched from inception to 20 January 2017. Eligibility criteria for selecting study Studies that reported the total number of participants/population by sex, total number of ACL injuries by sex and total person-time by sex were included. Results Twenty-eight studies were included. The IP and IR of ACL injury in female football players were 2.0% (95% CI 1.2% to 3.1%) and 2.0/10 000 athlete exposures (AEs) (95% CI 1.6 to 2.6; I 2 =91%) over a period of one season to 4 years. The IP and IR of ACL injury in male players were 3.5% (95% CI 0.7% to 8.2%) and 0.9/10 000 AEs (95% CI 0.7 to 1.1; I 2 =94%). Studies that evaluated matched cohorts of female and male players showed no difference in IP (relative risk=1.2; 95% CI 0.9 to 1.6; P=0.47) over a period of one season to 4 years. Women were at greater risk than men (incidence rate ratio (IRR)=2.2; 95% CI 1.6 to 3.1; I 2 =83%; P&lt;0.001). When accounting for participation level, the difference in IR between women and men was greatest for intermediate players (IRR=2.9; 95% CI 2.4 to 3.6) compared with amateur (IRR=2.6; 95% CI 1.4 to 4.8) and elite (IRR=2.0; 95% CI 1.1 to 3.4) players. Summary/conclusion Overall, more men sustained ACL injury in football. There was no difference in the relative risk of ACL injury between female and male football players in a window that spanned one season to 4 years. The IR of ACL injury among women was 2.2 times higher than the IR of ACL injury among men. The reported sex disparity in ACL injury was independent of participation level.
Sebaceous glands in the esophagus
Authors: U. Thalheimer, J. Wright, P. Maxwell, J. Firth, A. Millar
Journal: Endoscopy (2008)

A 44-year-old woman with a 2-year history of gastroesophageal reflux was referred to our endoscopy unit for investigation. She was taking over-the-counter ranitidine to treat her symptoms. On examination, the patient was overweight. Her past medical history revealed only borderline hypertension. She did not have dysplipidemia, she did not smoke, and she consumed alcohol only occasionally. Endoscopy showed yellow plaques in the esophagus, interpreted as possible Candida infection, and multiple cystic polyps in the gastric fundus, but the single esophageal biopsy that was taken reported only mild inflammation. A repeat endoscopy once again showed numerous yellowish papules in the esophagus ([Fig. 1]) and multiple biopsies were obtained at this examination.
Healthy eating and reduced risk of total and cause-specific deaths among African Americans and low-income adults in the southeastern United States
Authors: D Yu, JS Sonderman, Maciej S Buchowski, JK McLaughlin, X-O Shu, M Steinwandel, LB Signorello, X Zhang, MK Hargreaves, WJ Blot, W Zheng
Journal: PLoS Medicine (2014)
IDENTIFICATION OF CLINICAL, GENETIC AND ENDOSCOPIC PREDICTORS OF INCIDENT COLORECTAL CANCER IN LYNCH SYNDROME UNDER COLONOSCOPY SCREENING
Authors: A Sanchez Garcia, M Navarro, L Moreno, T Ocaña, F Rodríguez-Moranta, L Rodríguez-Alonso, A Soriano, T Ramon y Cajal, G Llort, C Yagüe, MD Picó, R Jover, A Lopez-Fernandez, E Martinez Castro, C Alvarez, X Bessa, L Rivas, J Cubiellas, D Rodriguez-Alcalde, A Dacal, M Herraiz, C Garau, L Bujanda, L Cid, C Poves, M Garzon, A Pizarro, I Salces, M Ponce, M Carrillo-Palau, E Aguirre, E Saperas, A Suarez, V Piñol, R Lleuger, E Martinez-Bauer, C Romero, A Gisbert, G Jung, S Carballal, L Rivero, M Pellisé, J Balmaña, J Brunet, A Castells, G Capellà, L Moreira, M Serra, F Balaguer
Journal: Endoscopy (2018)

Lynch syndrome (LS) families have a high risk of colorectal cancer (CRC) development. Colonoscopy every < 3 years decreases CRC incidence and mortality. However, recent studies show that up to 40% develop CRC during colonoscopy follow-up. Our aim is to assess the clinic-pathological, genetic and endoscopy quality measures that are predictors of CRC during colonoscopy surveillance in LS carriers.
Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus
Authors: Teri M. Greiling, Carina Dehner, Xinguo Chen, Kevin Hughes, Alonso J. Iñiguez, Marco Boccitto, Daniel Zegarra Ruiz, Stephen C. Renfroe, Silvio M. Vieira, William E. Ruff, Soyeong Sim, Christina Kriegel, Julia Glanternik, Xindi Chen, Michael Girardi, Patrick Degnan, Karen H. Costenbader, Andrew L. Goodman, Sandra L. Wolin, Martin A. Kriegel
Journal: Science Translational Medicine (2018)

Commensal bacterial orthologs of the human autoantigen Ro60 may trigger cross-reactive T and B cells that initiate and sustain chronic autoimmunity in lupus.
Abstract 17833: Role of 3-mercaptopyruvate Sulfur Transferase in Cardiac Ischemia/Reperfusion Injury
Authors: Sofia-Iris Bibli, Constantinos H Davos, Zhen Li, Athanasia Chatzianastasiou, Aimilia Varela, Antonia Katsouda, Noriyuki Nagahara, David J Lefer, Andreas Papapetropoulos
Journal: Circulation (2017)

Introduction:  Hydrogen sulfide (H 2 S) is endogenously produced by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfur transferase (3MST). CSE contributes significantly to cardiac H 2 S and exerts protective roles in ischemia/reperfusion (I/R) injury and heart failure. Recently, 3MST has attracted significant attention as a source of H 2 S; however, its function in the heart remains unknown.   Hypothesis:  3MST localizes in the cytosol and mitochondria, a key organelle for energy production and cardiomyocyte survival. We, thus, investigated the role of 3MST in the setting of myocardial I/R injury.   Methods and Results:  3MST transcripts were 2.5-fold higher compared to CSE in the murine heart. 3MST was localized mainly in cardiomyocytes and smooth muscle cells. More than 60% of 3MST expressed in cardiomyocytes was co-localized with mito-tracker. Despite complete absence of 3MST protein, free H 2 S and sulfane sulfur levels were not different between 3MST KO and wild-type (WT) mice. 3MST KO exhibited no differences in heart rate, fractional shortening, ejection fraction, intraventricular septum length, left ventricular (LV) end-diastolic diameter, end-systolic diameter and posterior wall thickness. CBS, CSE, endothelial nitric oxide synthase and soluble guanylate cyclase were expressed to similar levels in 3MST KO and WT, while cGMP-dependent protein kinase was elevated in 3MST mice. Male, but not female, 3MST KO mice subjected to 30 min ischemia (LAD ligation) followed by 2 hrs of reperfusion exhibited reduced myocardial infarct size (29± 3% vs. 43 ± 3 %, p  2 O 2  compared to the GFP-infected cells.   Conclusions:  We conclude that 3MST, unlike CSE, negatively impacts cardiomyocyte survival following ischemia/reperfusion. Thus, 3MST inhibition may represent a novel target for cardioprotection.
Rise and fall of outbreak-specific clone inside endemic pulsotype of Salmonella 4,[5],12:i:-; insights from high-resolution molecular surveillance in Emilia-Romagna, Italy, 2012 to 2015
Authors: Marina Morganti, Luca Bolzoni, Erika Scaltriti, Gabriele Casadei, Elena Carra, Laura Rossi, Paola Gherardi, Fabio Faccini, Norma Arrigoni, Anna Rita Sacchi, Marco Delledonne, Stefano Pongolini
Journal: Eurosurveillance (2018)

Background and aim Epidemiology of human non-typhoid salmonellosis is characterised by recurrent emergence of new clones of the pathogen over time. Some clonal lines of Salmonella have shaped epidemiology of the disease at global level, as happened for serotype Enteritidis or, more recently, for Salmonella 4,[5],12:i:-, a monophasic variant of serotype Typhimurium. The same clonal behaviour is recognisable at sub-serotype level where single outbreaks or more generalised epidemics are attributable to defined clones. The aim of this study was to understand the dynamics of a clone of Salmonella 4,[5],12:i:- over a 3-year period (2012–15) in a province of Northern Italy where the clone caused a large outbreak in 2013. Furthermore, the role of candidate outbreak sources was investigated and the accuracy of multilocus variable-number tandem repeat analysis (MLVA) was evaluated. Methods: we retrospectively investigated the outbreak through whole genome sequencing (WGS) and further monitored the outbreak clone for 2 years after its conclusion. Results: The study showed the transient nature of the clone in the population, possibly as a consequence of its occasional expansion in a food-processing facility. We demonstrated that important weaknesses characterise conventional typing methods applied to clonal pathogens such as Salmonella 4,[5],12:i:-, namely lack of accuracy for MLVA and inadequate resolution power for PFGE to be reliably used for clone tracking. Conclusions : The study provided evidence for the remarkable prevention potential of whole genome sequencing used as a routine tool in systems that integrate human, food and animal surveillance.
Association of higher proliferation of Ki67 with unfavorable prognostic factors and shorter survival in breast cancer.
Authors: Saadettin Kilickap, Yalcin Kaya, Birsen Yucel, Ersin Tuncer, Sahande Elagoz
Journal: Journal of Clinical Oncology (2012)

e11083 Background: The prognostic value of Ki67 expression level is yet unclear in breast cancer (BC). The aim of this study was to investigate the association between Ki67 expression levels and other prognostic factors in BC. Methods: Demographic, clinical and pathological features of the pts were retreived from the hospital records. Results: In this study, 163 pts with BC were analyzed. The mean age of the pts was 53.4±12.2 years. Median Ki67 level was 20% in this study. Ki67-high tumors were significantly associated with high grade (p&lt;0.001), lymphovascular invasion (p=0.001), estrogen receptor negativity (ER-) (p=0.035), Her2 (+) (p=0.001), advanced stage (p&lt;0.001) and lymph node involvement (LNI) (p&lt;0.003) of the tumor. There was no relationship between the age, perineural invasion, progesterone receptor and Ki67 positivity. Lower Ki67 levels were significantly associated with longer median relaps-free survival (RFS) compared to those of higher Ki67 levels (p=0.008). The overall survival (OS) was longer in pts with lower Ki67 levels than those with higher levels (p=0.017). Conclusions: High Ki67 expression was associated with ER-, Her2 (+), higher grade and LNI in BC. The level of Ki67 expression was a prognostic factor predicting the RFS and OS in BC pts. [Table: see text]
Abstract 024: Plasma Free Fatty Acids and Risk of Dementia: The Cardiovascular Health Study
Authors: Majken K Jensen, Petra Buzkova, Annette L Fitzpatrick, W. T. Longstreth, Lewis H Kuller, Oscar L Lopez, David S Siscovick, Jorge R Kizer, Joachim H Ix, Luc Djoussé, Kenneth J Mukamal
Journal: Circulation (2018)

Background: Plasma free fatty acids (FFAs) are a byproduct of lipolysis largely derived from adipose tissue. High plasma FFA levels have toxic effects on a variety of organs central to cardiometabolic disease. Whether FFAs associates with cognitive decline or dementia remains unknown. Objective: To assess the association of plasma FFAs with risk of cognitive decline and dementia. Methods: Plasma FFAs were measured in participant samples from the 1992-1993 study visit of the Cardiovascular Health Study (CHS) (mean age 74 yrs; 59% female; 14% African American [AA]; 24% APOE4 carriers). A total of 3,242 non-demented participants were followed with adjudication for dementia through 1998-1999 (n=456 cases). In addition, cognitive decline was assessed annually among all CHS participants using the 100-point modified Mini-Mental State examination (3MSE; n=4,417) and the Digital Symbol Substitution Test (DSST; n=4,254). Results: Higher plasma FFAs levels were positively associated with risk of dementia (Figure: Log-rank p-value=0.04). In Cox regression analysis adjusted for demographics, FFAs remained associated with risk of dementia (HR per SD [0.20 mEq/L] =1.10; 95% CI, 1.00-1.22). In fully adjusted models that included lifestyle factors, medical history, C-reactive protein, LDL-C, HDL-C, and 3MSE at baseline, the hazard ratio per SD was 1.13 (1.01-1.26), with a particularly strong association observed among AA participants (HR=1.49 [1.10-2.01], p interaction=0.08). FFA levels did not differ by APOE genotype, and adjustment for genotype did not influence results. FFA levels from the baseline visit were also associated with a decline in both cognitive assessments over 6 years of follow-up, with significant time x FFA interactions (p=0.04 for 3MSE and p=0.002 for DSST). We observed no interactions with APOE genotype or race for cognitive outcomes. Conclusions: In non-demented older men and women, higher plasma FFA levels are associated with faster cognitive decline and higher risk of dementia over the subsequent years.
Cytokine induced killer cells-assisted delivery of chlorin e6 mediated self-assembled gold nanoclusters to tumors for imaging and immuno-photodynamic therapy
Authors: Fangfang Xia, Wenxiu Hou, Yanlei Liu, Wentao Wang, Yu Han, Meng Yang, Xiao Zhi, Chenlu Li, Daizong Qi, Tianliang Li, Jesus Martinez de la Fuente, Chunlei Zhang, Jie Song, Daxiang Cui
Journal: Biomaterials (2018)
Association of Cerebrospinal Fluid Biomarkers of Central Nervous System Injury With Neurocognitive and Brain Imaging Outcomes in Children Receiving Chemotherapy for Acute Lymphoblastic Leukemia
Authors: Yin Ting Cheung, Raja B. Khan, Wei Liu, Tara M. Brinkman, Michelle N. Edelmann, Wilburn E. Reddick, Deqing Pei, Angela Panoskaltsis-Mortari, Deokumar Srivastava, Cheng Cheng, Leslie L. Robison, Melissa M. Hudson, Ching-Hon Pui, Kevin R. Krull
Journal: JAMA Oncology (2018)

Little is known about treatment-related neurotoxic mechanisms in children with acute lymphoblastic leukemia (ALL) treated with chemotherapy only.To examine concentration of cerebrospinal fluid (CSF) biomarkers of brain injury at ALL diagnosis and during cancer therapy and to evaluate associations with long-term neurocognitive and neuroimaging outcomes and relevant genetic polymorphisms.This prospective cohort study included 235 patients with ALL who received a chemotherapy-only protocol. Patients provided CSF samples after diagnosis and throughout treatment. At 5 or more years after the diagnosis, 138 (69.7%) of 198 eligible survivors participated in long-term follow-up assessments. Children were treated from June 1, 2000, through October 31, 2010. Follow-up was completed on October 21, 2014, and data were analyzed from August 1, 2015, through September 30, 2016.Plasma concentration of high-dose intravenous methotrexate sodium and number of triple intrathecal chemotherapy injections.The CSF samples were assayed at 5 points from diagnosis to reinduction for biomarkers of myelin degradation (myelin basic protein [MBP]), neuronal damage (nerve growth factor [NGF] and total and phosphorylated tau protein), astrogliosis (glial fibrillary acidic protein [GFAP]), and neuroinflammation (chitotriosidase). DNA was genotyped for polymorphisms in drug metabolism, oxidative stress, and neurodevelopment. Leukoencephalopathy was evaluated by brain imaging. At 5 or more years after the diagnosis, survivors completed neurocognitive testing and brain imaging of white matter integrity.Among the 235 patients with CSF samples (120 boys [51.1%] and 115 girls [48.9%]; mean [SD] age at diagnosis, 6.8 [4.7] years), MBP and GFAP levels were elevated at baseline and through consolidation. The number of intrathecal injections was positively correlated with NGF level increase at consolidation (r = 0.19; P = .005). Increases in GFAP (risk ratio [RR], 1.23; 95% CI, 1.09-1.40), MBP (RR, 1.06; 95% CI, 1.01-1.11), and total tau (RR, 1.76; 95% CI, 1.11-2.78) levels were associated with a higher risk for leukoencephalopathy and higher apparent diffusion coefficient in frontal lobe white matter 5 years after diagnosis (standardized estimate, 0.05; P < .001). Increase in total tau at consolidation was associated with worse attention (omissions z score estimate, -0.20; P = .04).Glial injury may be present at diagnosis of ALL. Neuronal injury was associated with intrathecal chemotherapy. The CSF biomarkers may be useful in identifying individuals at risk for worse neurologic outcomes, particularly those with genetic susceptibility to poor brain function.
DOES A ONE-DAY QUALITY IMPROVEMENT CONFERENCE ON SCREENING COLONOSCOPY INFLUENCE THE ADR?
Authors: B Majcher, D Penz, E Waldmann, A Hinterberger, A Dokladanska, A Szymanska, A Asaturi, M Trauner, M Ferlitsch
Journal: Endoscopy (2018)

Positive impact of different training strategies on quality of screening colonoscopy was showed in prior studies (Kaminiski et al, Gut 2016). These trainings lasted for longer period.
IN VIVO DIAGNOSTIC ACCURACY OF THE NICE CLASSIFICATION FOR PREDICTING DEEP INVASION IN COLONIC LESIONS
Authors: I Puig, M López-Cerón, A Arnau, O Rosiñol, M Cuatrecasas, A Herreros-de-Tejada, A Fernández, F Vida, O Nogales Rincón, L De Castro, J López-Vicente, P Vega, M Álvarez-González, J González Santiago, M Hernández-Conde, P Díez-Redondo, L Rivero Sánchez, A Gimeno-García, A Burgos, J García-Alonso, E Martínez-Bauer, B Peñas, G Muñoz, I Peligros, A Tardio Baiges, C González Lois, L Guerra Pastrian, S García Hernández, A Caminoa, T Zamora Martínez, L Elbouayadl, M López Carreira, A Casalots Casado, N Carames Díaz, M Iglesias, S del Carmen, M López-Ibáñez, M Pantaleón, M Solano, A Álvarez, S Soto, P Estévez, M Serra-Burriel, M Bustamante, D Rodríguez Alcalde, M Pellisé
Journal: Endoscopy (2018)

The NICE 3 category in the NBI International Colorectal Endoscopic classification was designed to predict deep submucosal invasion in colorectal lesions for which surgery is indicated.
SUCCESS AND FAILURES OF DOUBLE-BALLOON ENTEROSCOPY IN DIAGNOSTIC AND TREATMENT OF PEUTZ-JEGHERS SYNDROME
Authors: A Varabei, A Makhmudov, A Subach, T Chakhovich, N Lahodzich
Journal: Endoscopy (2018)

To evaluate possibilities of double-balloon enteroscopy (DBE) in patients who have undergone operations for enteric intussusception.
EFFICACY OF A THREE-DAY TRAINING COURSE IN ESD USING A LIVE PORCINE MODEL: A PROSPECTIVE EVALUATION
Authors: N Chapelle, N Musquer, E Metivier-Cesbron, D Luet, C Volteau, M Le Rhun, E Coron
Journal: Endoscopy (2018)

Endoscopic submucosal dissection (ESD) is the method of choice for “en-bloc” resection of superficial tumors. European countries are late in implementing this method, and current guidelines recommend training on animal models. The objective of our study was to prospectively evaluate the efficiency of an ESD training course using live anaesthetized pigs.
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
Authors: Gillian Douglas, Ashley B Hale, Jyoti Patel, Surawee Chuaiphichai, Ayman Al Haj Zen, Victoria S Rashbrook, Lucy Trelfa, Mark J Crabtree, Eileen McNeill, Keith M Channon
Journal: Cardiovascular Research (2018)

GTP cyclohydrolase I catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases (NOS). Both eNOS and iNOS have been implicated in the progression of atherosclerosis, with opposing effects in eNOS and iNOS knockout mice. However, the pathophysiologic requirement for BH4 in regulating both eNOS and iNOS function, and the effects of loss of BH4 on the progression of atherosclerosis remains unknown.Hyperlipidemic mice deficient in Gch1 in endothelial cells and leucocytes were generated by crossing Gch1fl/flTie2cre mice with ApoE-/- mice. Deficiency of Gch1 and BH4 in endothelial cells and myeloid cells was associated with mildly increased blood pressure. High fat feeding for 6 weeks in Gch1fl/flTie2CreApoE-/- mice resulted in significantly decreased circulating BH4 levels, increased atherosclerosis burden and increased plaque macrophage content. Gch1fl/flTie2CreApoE-/- mice showed hallmarks of endothelial cell dysfunction, with increased aortic VCAM-1 expression and decreased endothelial cell dependent vasodilation. Furthermore, loss of BH4 from pro-inflammatory macrophages resulted in increased foam cell formation and altered cellular redox signalling, with decreased expression of antioxidant genes and increased reactive oxygen species. Bone marrow chimeras revealed that loss of Gch1 in both endothelial cells and leucocytes is required to accelerate atherosclerosis.Both endothelial cell and macrophage BH4 play important roles in the regulation of NOS function and cellular redox signalling in atherosclerosis.
Abstract 21316: Mitochondrial DNA Copy Number and Ventricular Remodeling: Multi-Ethnic Study of Atherosclerosis
Authors: Bharath Ambale Venkatesh, Mohammad Ostovaneh, Susan Heckbert, Jose Vargas, Donna Arnett, Stephen Rich, Kent Taylor, Gregory Hundley, Wendy Post, Antoinette Gomes, David Bluemke, Colin Wu, Dan Arking, Eliseo Guallar, Joao A Lima
Journal: Circulation (2017)

Introduction: The effect of mitochondrial DNA copy number (mtDNA-CN), which reflects energy reserves and oxidative stress, on left ventricular (LV) remodeling in the general population may provide insights into heart failure development. Hypothesis: Lower mtDNA-CN values from blood samples will be associated with concentric remodeling. Methods: Longitudinal analyses of MESA participants with mtDNA-CN and MRI-measured LV mass to volume ratio (MVR) at baseline and the 10-year follow-up (n=2735) were performed. mtDNA-CN was estimated using 25 high-quality mitochondrial single nucleotide polymorphisms from the Affymetrix 6.0 array. Analyses were adjusted for age, sex, and field center, and standardized. LV mass and volumes were measured from cine images. Concentric remodeling was assessed by higher MVR. The association of mtDNA-CN with MVR, adjusted for the ASCVD/AHA risk score as a time-varying covariate, was assessed with mixed-effects models. Longitudinal change in MVR and LV ejection fraction (LVEF) was assessed with an interaction term of mtDNA-CN and time. Results: Population average age (SD) was 60 (9) years, with 48% males, 42% Caucasians, 12% Chinese, 22% African-American and 21% Hispanics. Mean MVR was 0.95 (0.18) g/ml at baseline and 1.05 (0.23) g/ml at follow-up. Lower mtDNA-CN was associated with higher MVR values (coef=-0.006, p=0.01, Fig 1), as well as greater longitudinal change in slope of this association (interaction term coef =-0.008, p=0.03) with small effect sizes (Cohens f2= -0.018 and -0.019 respectively). The longitudinal change reflected greater increase in concentric remodeling in those with low mtDNA-CN at baseline. mtDNA-CN values were not associated with LVEF. Conclusions: Lower mtDNA-CN was associated with both high levels at baseline and longitudinally increasing levels of concentric remodeling in a multiethnic population free of CVD at baseline. Altered myocardial energy reserves may contribute to concentric remodeling