tbuckley/cabot-search huggingface dataset:
Evaluation des prothèses métalliques expansives dans le traitement des sténoses et fistules oesophagiennes: Expérience d'un service d'endoscopie digestive
Authors: S Ghani, A Sarhani, M Acharki, M Salihoun, N Kabbaj
Journal: Endoscopy (2018)

Les prothèses oesophagiennes métalliques sont indiquées essentiellement dans le traitement palliatif d'une dysphagie dans le cas d'un cancer inopérable ou récidivant de l'oesophage, en cas de fistule oeso-bronchique, ou plus rarement pour calibration des sténoses bénignes. Le but de notre travail est d'évaluer les indications et les résultats des prothèses métalliques expansives dans le traitement des sténoses et fistules oesophagiennes dans un service d'endoscopie digestive.
Exacerbation Risk and Type 2 Inflammation in Placebo Patients During a Phase 2b Study of Dupilumab in Patients With Uncontrolled Persistent Asthma
Authors: Mario Castro, Brian N. Swanson, Shyamalie Jayawardena, Jennifer D. Hamilton, Nikhil Amin, Gianluca Pirozzi, Neil M.H. Graham, Ariel Teper
Journal: Journal of Allergy and Clinical Immunology (2018)
EFFICACITE DES CLIPS OVESCO DANS LES PERFORATIONS COLIQUES IATROGENES PER ENDOSCOPIQUE: ETUDE RETROSPECTIVE MULTICENTRIQUE AU SEIN DU GROUPE GRAPHE (Groupe de Réflexion et d'Action des Praticiens Hospitaliers en Endoscopie)
Authors: Y Le Baleur, J Rivory, G Rahmi, JC Duchmann, J Branche, JB Chevaux, A Charachon, JM Gonzalez, J Jacques, S Koch, S Hakim, E Coron, S Leblanc, J Levy, P Bichard, J Privat, F Fumex, L Poincloux
Journal: Endoscopy (2018)

la perforation colique iatrogene per endoscopique reste une des complications les plus graves de la coloscopie diagnostique et thérapeutique de part la morbi mortalité induite. Les Macro clips OVESCO sont considérés comme equivalents à une suture chirurgicale depuis leur apparition en 2010 mais leur utilisation en pratique clinique a été peu évaluée à l'echelon national.
Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy
Authors: Simona Soverini, Manuela Mancini, Luana Bavaro, Michele Cavo, Giovanni Martinelli
Journal: Molecular Cancer (2018)

Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion gene resulting from the t(9;22)(q34;q11) chromosomal translocation, is thought to be the driver event responsible for initiation and maintenance of chronic myeloid leukemia (CML). BCR-ABL1 was one of the first tyrosine kinases to be implicated in a human malignancy and the first to be successfully targeted. Imatinib mesylate, the first tyrosine kinase inhibitor (TKI) to be approved for therapeutic use, was hailed as a magic bullet against cancer and remains one of the safest and most effective anticancer agents ever developed. Second- and third-generation TKIs were later introduced to prevent or counteract the problem of drug resistance, that may arise in a small proportion of patients. They are more potent molecules, but have been associated to more serious side effects and complications. Patients achieving stable optimal responses to TKI therapy are predicted to have the same life expectancy of the general population. However, TKIs do not ‘cure’ CML. Only a small proportion of cases may attempt therapy discontinuation without experiencing subsequent relapse. The great majority of patients will have to assume TKIs indefinitely – which raises serious pharmacoeconomic concerns and is now shifting the focus from efficacy to compliance and quality of life issues. Here we retrace the steps that have led from the biological acquisitions regarding BCR-ABL1 structure and function to the development of inhibitory strategies and we discuss drug resistance mechanism and how they can be addressed.
Nasal eosinophil correlation with aeroallergen sensitization in children
Authors: Beom joon Kim, Woori Bae, Kyunghoon KIM, Hyejin Lee, Eun Ae Yang, Hwan Soo Kim, Yoon Hong Chun, Jong-seo Yoon, Hyun Hee Kim, Jin Tack Kim
Journal: Journal of Allergy and Clinical Immunology (2018)
Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity
Authors: Ines Valenta, Zoltan V. Varga, Heather Valentine, Resat Cinar, Andrew Horti, William B. Mathews, Robert F. Dannals, Kimberley Steele, George Kunos, Richard L. Wahl, Martin G. Pomper, Dean F. Wong, Pal Pacher, Thomas H. Schindler
Journal: JACC. Cardiovascular imaging (2018)
Drainage de la vésicule biliaire par pose d'une prothèse d'apposition AXIOS™ sous échoendoscopie
Authors: J Privat, B Napoléon, F Pinard
Journal: Endoscopy (2018)

Chez les patients à haut risque chirurgical pour la cholécystectomie, le drainage percutané est considéré comme le traitement de remplacement habituel.
CSF oxytocin in anorexia nervosa and bulimia nervosa: clinical and pathophysiologic considerations
Authors: M A Demitrack, M D Lesem, S J Listwak, H A Brandt, D C Jimerson, P W Gold
Journal: American Journal of Psychiatry (1990)

Oxytocin is a hypothalamic neuropeptide with both centrally and peripherally directed pathways. Data from experimental animals indicate that oxytocin impairs consolidation of aversively conditioned behaviors and is released after feeding or experimental gastric distension. The authors report that the mean CSF oxytocin level of five underweight women with restricting anorexia, but not 12 underweight bulimic anorexic women or 35 normal-weight women with bulimia nervosa, was significantly lower than the level of 11 control subjects. Restricting anorexic patients' low CSF oxytocin levels may reflect their persistently low food intake, and this behavior may exacerbate their tendency for perseverative preoccupation with adverse consequences of food intake.
Lower limb biomechanics in femoroacetabular impingement syndrome: a systematic review and meta-analysis
Authors: Matthew G King, Peter R Lawrenson, Adam I Semciw, Kane J Middleton, Kay M Crossley
Journal: British Journal of Sports Medicine (2018)

Objective (1) Identify differences in hip and pelvic biomechanics in patients with femoroacetabular impingement syndrome (FAIS) compared with controls during everyday activities (eg, walking, squatting); and (2) evaluate the effects of interventions on hip and pelvic biomechanics during everyday activities. Design Systematic review. Data sources Medline, CINAHL, EMBASE, Scopus and SPORTDiscus until February 2017. Methods Primary aim: studies that investigated hip or pelvic kinematics and/or joint torques of everyday activities in patients with FAIS compared with the asymptomatic contralateral limb or a control group. Secondary aim: studies that evaluated effects of conservative or surgical interventions on patients with FAIS using pre-post or controlled clinical trial designs. Biomechanical data must have been collected using three-dimensional motion capture devices. Reporting quality was assessed using the Epidemiological Appraisal Instrument and data were pooled (standardised mean difference (SMD), 95% CI) where populations and primary outcomes were similar. Results Fourteen studies were included (11 cross-sectional and three pre/post intervention), varying between low and moderate reporting quality. Patients with FAIS walked with a lower: peak hip extension angle (SMD −0.40, 95% CI −0.71 to −0.09), peak internal rotation angle (−0.67, 95% CI −1.19 to −0.16) and external rotation joint torque (−0.71, 95% CI −1.07 to −0.35), and squatted to a lesser depth with no difference in hip flexion range. Pre/post intervention data were limited in number and quality, and to surgical cohorts. Conclusion This review suggests that patients with FAIS may demonstrate hip biomechanical impairments during walking and squatting, with minimal literature available to comment on other tasks. Clinical relevance The information presented in the review provides insight into the biomechanical differences associated with FAIS; however, the between-group differences were small to moderate. This information may aid in the development of management strategies for people with the condition. PROSPEROregistration number CRD42016038677.
Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: the DURAPOP randomised clinical trial
Authors: Philippe Montravers, Florence Tubach, Thomas Lescot, Benoit Veber, Marina Esposito-Farèse, Philippe Seguin, Catherine Paugam, Alain Lepape, Claude Meistelman, Joel Cousson, Antoine Tesniere, Gaetan Plantefeve, Gilles Blasco, Karim Asehnoune, Samir Jaber, Sigismond Lasocki, Herve Dupont
Journal: Intensive Care Medicine (2018)
Co-treatment with vorinostat and Aurora kinase inhibitor MK-0457 exerts synergistic antileukemia activity against AML and CML cells, including those expressing mutant Bcr-AblT315I
Authors: Warren Fiskus, Yongchao Wang, Rajeshree Joshi, Rekha Rao, Pearl Lee, Yonghua Yang, Kelly Eaton, Jianguang Chen, Ravindra Kolhe, Pravina Fernandez, Anand Jillella, Carolyn Buser, Kapil Bhalla
Journal: Cancer Research (2008)

2558   Aurora A and B kinases are serine/threonine kinases with critical roles in the mitosis of eukaryotic cells. Deregulation and overexpression of Aurora kinases is linked to tumorigenesis. MK-0457 is a pan-aurora kinase inhibitor, which functionally exhibits an anti-mitosis phenotype that mimics Aurora B inhibition. MK-0457 is also significantly active against Bcr-Abl and FLT-3 tyrosine kinases. In the present studies, we determined that treatment with the Aurora kinase inhibitor MK-0457 inhibits the activity of Aurora kinases in the cultured acute myeloid leukemia HL-60, OCI-AML3 and K562, as well as in primary human AML and CML cells. This was represented by decreased phosphorylation by Aurora kinase substrates, including serine (S) 10 on histone H3 and survivin. MK-0457 treatment induced multipolar spindle formation and aberrant mitosis (detected by confocal immunofluorescent microscopy), DNA endo-reduplication (by flow cytometry) and apoptosis of HL-60, OCI-AML3 and K562 cells. Treatment with MK-0457 also depleted the levels of autophosphorylated Bcr-Abl, pSTAT5 and pCrkL in the CML cells. MK-0457 treatment induced apoptosis of murine BaF3 cells with ectopic overexpression of either wild type or mutant forms of Bcr-Abl, including Bcr-AblT315I, which is resistant to the Bcr-Abl kinase inhibitors imatinib, dasatinib and nilotinib. By inhibiting histone deacetylase (HDAC) 6, the pan- (HDAC) inhibitor vorinostat induces acetylation and inhibition of hsp90 chaperone function, resulting in depletion of wild type or mutant forms of Bcr-Abl, as well as of c-Raf and AKT in CML cells. As compared to treatment with either agent alone, co-treatment with vorinostat and MK-0457 resulted in more attenuation of the activity and levels of Bcr-Abl and Aurora kinases in K562 and Aurora kinases in HL-60 and OCI-AML3 cells. This was associated with synergistic apoptotic effects of the combination in K562, HL-60 and OCI-AML3 cells, as well as in BaF3 cells with ectopic overexpression of wild type or Bcr-AblT315I, as determined by isobologram analyses. Finally, co-treatment with MK-0457 and vorinostat induced more loss of cell viability of primary AML and imatinib refractory CML cells than treatment with either agent alone. Again, this was associated with evidence for simultaneous inhibition of Bcr-Abl and Aurora kinases. These findings highlight MK-0457 and vorinostat as a rational and synergistic combination, worthy of in vivo testing against human leukemia cells, especially against Bcr-AblT315I expressing CML.
Causes d'échec à la coloscopie totale: étude rétrospective sur 5 ans
Authors: AG Eyi Nguema, A El Farouki, I Haraki, S Oubaha, Z Samlani, K Krati
Journal: Endoscopy (2018)

La coloscopie joue un rôle prépondérant dans la prise en charge des lésions précancéreuses colorectales. La performance de cet examen est principalement liée à la qualité de la préparation colique. Le but de notre travail était de déterminer la fréquence des coloscopies incomplètes toutes indications confondues, et les raisons de l'exploration incomplète.
Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications
Authors: Koen Van den Berge, Fanny Perraudeau, Charlotte Soneson, Michael I. Love, Davide Risso, Jean-Philippe Vert, Mark D. Robinson, Sandrine Dudoit, Lieven Clement
Journal: Genome biology (2018)

Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go undetected and induce an excess of zero read counts, leading to power issues in differential expression (DE) analysis. This has triggered the development of bespoke scRNA-seq DE methods to cope with zero inflation. Recent evaluations, however, have shown that dedicated scRNA-seq tools provide no advantage compared to traditional bulk RNA-seq tools. We introduce a weighting strategy, based on a zero-inflated negative binomial model, that identifies excess zero counts and generates gene- and cell-specific weights to unlock bulk RNA-seq DE pipelines for zero-inflated data, boosting performance for scRNA-seq.
Validity and Responsiveness of Urticaria Activity and Impact Measure (U-AIM), a New Patient-Reported Tool to Assess Disease Activity and Impact in Patients with Chronic Spontaneous/Idiopathic Urticaria (CSU/CIU)
Authors: Marcus Maurer, Evgeniya N. Antonova, Susan D. Mathias, Ross D. Crosby, James L. Zazzali
Journal: Journal of Allergy and Clinical Immunology (2018)
La ligature endoscopique des varices oesophagiennes chez l'enfant dans une unité d'endoscopie pour adulte: Résultats préliminaires d'une étude prospective
Authors: A Sarhani, S Ghani, M Salihoun, M Acharki, N Kabbaj
Journal: Endoscopy (2018)

L'hémorragie digestive par rupture de varices oesophagiennes (VO) est une complication redoutable de l'hypertension portale. L'examen endoscopique, en plus de son intérêt diagnostique, a un intérêt thérapeutique incontournable. Nous rapportant à travers ce travail notre expérience en tant qu'une unité d'endoscopie digestive pour adulte dans la ligature des varices oesophagiennes (LVO) chez l'enfant.
Increased Incidence of Pseudoaneurysm Bleeding With Lumen-Apposing Metal Stents Compared to Double-Pigtail Plastic Stents in Patients With Peripancreatic Fluid Collections
Authors: Bryan Brimhall, Samuel Han, Philip D. Tatman, Toshimasa J. Clark, Sachin Wani, Brian Brauer, Steven Edmundowicz, Mihir S. Wagh, Augustin Attwell, Hazem Hammad, Raj J. Shah
Journal: Clinical Gastroenterology and Hepatology (2018)
Hypersensitivity Reactions To Low Molecular Weight Heparins: A Case Series
Authors: Wendy Vargas Porras, Ana Gonzalez Moreno, Ana M. Nieto, Maria Dolores Alonso Diaz de Durana, Monica Rodriguez, María Del Mar Moro, Aura P. Silva Barajas, Sabela Perez Codesido
Journal: Journal of Allergy and Clinical Immunology (2018)
Cigarette Brand Preference and Pro-Tobacco Advertising Among Middle and High School Students — United States, 2012–2016
Authors: Siobhan N. Perks, Brian Armour, Israel T. Agaku
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Nearly all adult smokers first try cigarettes before age 18 years (1), and adolescents can show symptoms of nicotine dependence within days to weeks of the onset of occasional cigarette smoking (2). Having a usual cigarette brand among adolescent smokers could reflect exposure and receptivity to pro-tobacco advertising and tobacco product appeal (1). To identify usual cigarette brands smoked among U.S. middle and high school students who were current (past 30-day) cigarette smokers, CDC analyzed data from the 2012-2016 National Youth Tobacco Survey (NYTS). Marlboro, Newport, and Camel were the most commonly reported brands smoked during 2012-2016; in 2016, these three were the brands usually smoked for 73.1% and 78.7% of current cigarette smokers in middle and high school, respectively. These three brands also were the three most commonly identified as having a "favorite cigarette ad" in 2012. Efforts to reduce youth exposure to pro-tobacco advertising could help reduce youth smoking (1,3).
Capturing resting T cells: the perils of PLL
Authors: Ana Mafalda Santos, Aleks Ponjavic, Marco Fritzsche, Ricardo A. Fernandes, Jorge Bernardino de la Serna, Martin J. Wilcock, Falk Schneider, Iztok Urbančič, James McColl, Consuelo Anzilotti, Kristina A. Ganzinger, Meike Aßmann, David Depoil, Richard J. Cornall, Michael L. Dustin, David Klenerman, Simon J. Davis, Christian Eggeling, Steven F. Lee
Journal: Nature Immunology (2018)
First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
Authors: Rizwan Romee, Sarah Cooley, Melissa M. Berrien-Elliott, Peter Westervelt, Michael R. Verneris, John E. Wagner, Daniel J. Weisdorf, Bruce R. Blazar, Celalettin Ustun, Todd E. DeFor, Sithara Vivek, Lindsey Peck, John F. DiPersio, Amanda F. Cashen, Rachel Kyllo, Amy Musiek, András Schaffer, Milan J. Anadkat, Ilana Rosman, Daniel Miller, Jack O. Egan, Emily K. Jeng, Amy Rock, Hing C. Wong, Todd A. Fehniger, Jeffrey S. Miller
Journal: Blood (2018)
Abstract #5397: The HDAC inhibitor SNDX-275 synergizes with erlotinib and induces mesenchymal to epithelial transition in pancreatic carcinoma
Authors: Veronika Franekova, Samir Witta, Paul A. Bunn, Fred Hirsch
Journal: Cancer Research (2009)

Introduction: Transition from epithelial to mesenchymal phenotype (EMT) is a critical step in cancer cell invasion, migration and resistance to the epidermal growth factor receptor inhibitors (EGFR). In this study we evaluated the effect of the histone deacetylase inhibitor (HDACi) SNDX-275 in inducing the expression of E-cadherin and the growth inhibitory effect when combined with erlotinib in pancreatic cancer cell lines. Methods: 9 pancreatic cancer cell lines were used in this study. Protein expression was analyzed using immunohistochemistry (IHC) and western blot analysis (WB). RNA expression was evaluated using real time RT-PCR. The growth inhibitory effects of the SNDX-275 and erlotinib each alone or in combination was analyzed using the MTT assay. Results: 6 out of the 9 cell lines were sensitive and 3 were resistant to erlotinib (growth inhibition >50% and    Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5397.
Mechanism of Hyperkalemia-Induced Metabolic Acidosis
Authors: Autumn N. Harris, P. Richard Grimm, Hyun-Wook Lee, Eric Delpire, Lijuan Fang, Jill W. Verlander, Paul A. Welling, I. David Weiner
Journal: Journal of the American Society of Nephrology (2018)

Background Hyperkalemia in association with metabolic acidosis that are out of proportion to changes in glomerular filtration rate defines type 4 renal tubular acidosis (RTA), the most common RTA observed, but the molecular mechanisms underlying the associated metabolic acidosis are incompletely understood. We sought to determine whether hyperkalemia directly causes metabolic acidosis and, if so, the mechanisms through which this occurs. Methods We studied a genetic model of hyperkalemia that results from early distal convoluted tubule (DCT)–specific overexpression of constitutively active Ste20/SPS1-related proline-alanine–rich kinase (DCT-CA-SPAK). Results DCT-CA-SPAK mice developed hyperkalemia in association with metabolic acidosis and suppressed ammonia excretion; however, titratable acid excretion and urine pH were unchanged compared with those in wild-type mice. Abnormal ammonia excretion in DCT-CA-SPAK mice associated with decreased proximal tubule expression of the ammonia-generating enzymes phosphate-dependent glutaminase and phosphoenolpyruvate carboxykinase and overexpression of the ammonia-recycling enzyme glutamine synthetase. These mice also had decreased expression of the ammonia transporter family member Rhcg and decreased apical polarization of H + -ATPase in the inner stripe of the outer medullary collecting duct. Correcting the hyperkalemia by treatment with hydrochlorothiazide corrected the metabolic acidosis, increased ammonia excretion, and normalized ammoniagenic enzyme and Rhcg expression in DCT-CA-SPAK mice. In wild-type mice, induction of hyperkalemia by administration of the epithelial sodium channel blocker benzamil caused hyperkalemia and suppressed ammonia excretion. Conclusions Hyperkalemia decreases proximal tubule ammonia generation and collecting duct ammonia transport, leading to impaired ammonia excretion that causes metabolic acidosis.
Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation
Authors: Elena Viganò, Jay Gunawardana, Anja Mottok, Tessa Van Tol, Katina Mak, Fong Chun Chan, Lauren Chong, Elizabeth Chavez, Bruce Woolcock, Katsuyoshi Takata, David Twa, Hennady P. Shulha, Adèle Telenius, Olga Kutovaya, Stacy S. Hung, Shannon Healy, Susana Ben-Neriah, Karen Leroy, Philippe Gaulard, Arjan Diepstra, Robert Kridel, Kerry J. Savage, Lisa Rimsza, Randy Gascoyne, Christian Steidl
Journal: Blood (2018)
Associations Between Marijuana Use and Cardiovascular Risk Factors and Outcomes
Authors: Divya Ravi, Mehrnaz Ghasemiesfe, Deborah Korenstein, Thomas Cascino, Salomeh Keyhani
Journal: Annals of Internal Medicine (2018)

Marijuana use is increasing in the United States, and its effect on cardiovascular health is unknown.To review harms and benefits of marijuana use in relation to cardiovascular risk factors and clinical outcomes.PubMed, MEDLINE, EMBASE, PsycINFO, and the Cochrane Library between 1 January 1975 and 30 September 2017.Observational studies that were published in English, enrolled adults using any form of marijuana, and reported on vascular risk factors (hyperglycemia, diabetes, dyslipidemia, and obesity) or on outcomes (stroke, myocardial infarction, cardiovascular mortality, and all-cause mortality in cardiovascular cohorts).Study characteristics and quality were assessed by 4 reviewers independently; strength of evidence for each outcome was graded by consensus.13 and 11 studies examined associations between marijuana use and cardiovascular risk factors and clinical outcomes, respectively. Although 6 studies suggested a metabolic benefit from marijuana use, they were based on cross-sectional designs and were not supported by prospective studies. Evidence examining the effect of marijuana on diabetes, dyslipidemia, acute myocardial infarction, stroke, or cardiovascular and all-cause mortality was insufficient. Although the current literature includes several long-term prospective studies, they are limited by recall bias, inadequate exposure assessment, minimal marijuana exposure, and a predominance of low-risk cohorts.Poor- or moderate-quality data, inadequate assessment of marijuana exposure and minimal exposure in the populations studied, and variation in study design.Evidence examining the effect of marijuana on cardiovascular risk factors and outcomes, including stroke and myocardial infarction, is insufficient.National Heart, Lung, and Blood Institute. (PROSPERO: CRD42016051297).
Mise en place de fiducials surrénaliens sous contrôle écho-endoscopique (EE) et radioscopique avant radiothérapie stéréotaxique (RTS): intérêt, faisabilité et sécurité à propos de 6 cas consécutifs (Première série rapportée)
Authors: P Guibert, C Carrie, M Sarabi, F Desseigne, C de la Fouchardière, S Négrier, V Avrillon, EM Neidhart, P Rochefort, C Moncharmont, L Claude, I Martel-Lafay
Journal: Endoscopy (2018)

La radiothérapie guidée par l'image (IGRT) utilise les techniques d'imagerie moderne pour cibler et suivre la tumeur lors des mouvements respiratoires, ce qui autorise une diminution des marges autour de ce volume tumoral et une meilleure épargne des tissus de voisinage, tout en délivrant de fortes doses à la tumeur.