tbuckley/cabot-search huggingface dataset:
TCT-786 Antithrombotic Management for Atrial Fibrillation Patient Undergoing Transcatheter Aortic Valve Replacement
Authors: M Chadi Alraies, Homam Moussa Pacha, Kyle Buchanan, Toby Rogers, Edward Koifman, Arie Steinvil, Mohamad Soud, Petros Okubagzi, Linzhi Xu, Rebecca Torguson, Itshac Itsik Ben-Dor, Lowell Satler, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2017)
A chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2’-deoxycytidine treatment and oligonucleotide microarray
Authors: Satoshi Yamashita, Kazuki Moriguchi, Yoshimi Tsujino, Masae Tatematsu, Toshikazu Ushijima
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

1623 

To identify novel methylation-silenced genes in gastric cancers, we here performed a chemical genomic screening, a genome-wide search for genes up-regulated by treatment with a demethylating agent, 5-aza-2’-deoxycytidine (5-aza-dC). After treatment of a gastric cancer cell line, AGS, with 5-aza-dC at 1 μM, 579 genes were up-regulated at 16-fold or more, using an oligonucleotide microarray with 39,000 genes. From these genes, we selected 44 known genes on autosomes whose silencing in gastric cancer has not been reported. Thirty-two of them had CpG islands (CGIs) in their putative promoter regions, and the CGIs of all the 32 genes were found to be methylated in AGS by methylation-specific PCR. Analysis of 5 additional gastric cancer cell lines (MKN28, MKN45, HSC44, HSC57, KATOIII) showed that 27 genes were methylated in multiple gastric cancer cell lines. AGS cell line was expected to have 421 ± 75 (95 % confidence interval) methylation-silenced genes. Additionally, we analyzed methylation statuses of 16 potential tumor-related genes with promoter CGIs and up-regulation of 4-fold or more, and 14 of them were methylated in AGS. Methylation statuses of the 32 randomly selected and 16 potential tumor-related genes were analyzed in 10 primary gastric cancers, and 42 genes ( ABHD9 , ADFP , ALDH1A3 , ANXA5 , AREG , BDNF , BMP7 , CAV1 , CDH2 , CLDN3 , CTSL , EEF1A2 , F2R , FADS1 , FSD1 , FST , FYN , GPR54 , GREM1 , IGFBP3 , IGFBP7 , IRS2 , KISS1 , MARK1 , MLF1 , MSX1 , MTSS1 , NT5E , PAX6 , PLAGL1 , PLAU , PPIC , RBP4 , RORA , SCRN1 , TBX3 , TFAP2C , TNFSF9 , ULBP2 , WIF1 , ZNF177 , and ZNF559 ) were methylated in at least one primary gastric cancer. Although some of these genes could be causally related to development and progression of gastric cancers, it was likely that the majority do not have such roles, considering the large number of methylation-silenced genes. Therefore, potential tumor-related genes were selected based upon their known functions, chromosomal locations, methylation in primary samples, and expression in normal gastric mucosae. MTSS1/MIM/BEG4 (8q22) met all these criteria, and was a good candidate for a tumor-related gene. The usefulness of chemical genomic screening was also confirmed.
Vigilancia de la enfermedad de Lyme en Alemania, 2002-2003
Authors: W H Mehnert, G Krause
Journal: Eurosurveillance (2005)

La enfermedad de Lyme o borreliosis de Lyme es una infeccion potencialmente grave, frecuente en Alemania, pero con escasa informacion sobre su incidencia, su distribucion y sus manifestaciones clinicas. Esta enfermedad no es de declaracion obligatoria en Alemania, pero seis de los 16 estados alemanes - Berlin, Brandenburg, Mecklenburg-Vorpommern, Sachsen, Sachsen-Anhalt y Thuringen, la incluyeron en su sistema de notificacion obligatoria. Los esfuerzos hechos en estos estados para monitorizar los casos confirmados a traves de la declaracion constituyen una contribucion importante para comprender la epidemiologia de esta enfermedad en Alemania. El siguiente informe resume el analisis de los casos de enfermedad de Lyme declarados al Instituto Robert-Koch en 2002-2003. 
La incidencia media de la enfermedad de Lyme en los seis estados del este de Alemania aumento un 31%, pasando de 17,8/100.000 en 2002 a 23,3/100.000 en 2003. La distribucion por grupos de edad de los pacientes puso de manifiesto dos picos de incidencia : en ninos de cinco a nueve anos, y en las personas mayores, entre 60 y 64 anos en 2002 y de 65 a 69 en 2003. El 55% de los pacientes eran mujeres en los dos anos. Cerca de un 86% de los casos se declararon entre los meses de mayo y octubre. Un eritema migratorio afecto a 2.697 pacientes (89,3%) en 2002 y a 3.442 (86,7%) en 2003. 
Cuando una enfermedad se transmite por un vector, como la enfermedad de Lyme, el riesgo de infeccion depende del grado y de la duracion del contacto entre los humanos y las garrapatas infectadas por Borrelia burgdorferi. Puesto que las garrapatas infectadas se encuentran probablemente en toda Alemania, la situacion de los otros diez estados alemanes debe ser similar a la descrita en nuestro estudio.
TCT-778 Valve-In-Valve (ViV) Transcatheter Aortic Valve Replacement (TAVR): A Comparison of Failed Stentless and Stented Surgical Bio-prosthetic Aortic Valve
Authors: Charles Choi, Vivian Cheng, Waqas Qureshi, Daniel Green, Neal Kon, Ted Kincaid, Sanjay Gandhi, Robert Applegate, David Zhao
Journal: Journal of the American College of Cardiology (2017)
Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations
Authors: Yuri Milaneschi, Femke Lamers, Wouter J. Peyrot, Bernhard T. Baune, Gerome Breen, Abbas Dehghan, Andreas J. Forstner, Hans J. Grabe, Georg Homuth, Carol Kan, Cathryn Lewis, Niamh Mullins, Matthias Nauck, Giorgio Pistis, Martin Preisig, Margarita Rivera, Marcella Rietschel, Fabian Streit, Jana Strohmaier, Alexander Teumer, Sandra Van der Auwera, Naomi R. Wray, Dorret I. Boomsma, Brenda W. J. H. Penninx
Journal: JAMA Psychiatry (2017)

The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode.To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP] and leptin).This multicenter study assembled genome-wide genotypic and phenotypic measures from 14 data sets of the Psychiatric Genomics Consortium. Data sets were drawn from case-control, cohort, and population-based studies, including 26 628 participants with established psychiatric diagnoses and genome-wide genotype data. Data on BMI were available for 15 237 participants. Data were retrieved and analyzed from September 28, 2015, through May 20, 2017.Lifetime DSM-IV MDD was diagnosed using structured diagnostic instruments. Patients with MDD were stratified into subgroups according to change in the DSM-IV A/W symptoms as decreased or increased.Data included 11 837 participants with MDD and 14 791 control individuals, for a total of 26 628 participants (59.1% female and 40.9% male). Among participants with MDD, 5347 (45.2%) were classified in the decreased A/W and 1871 (15.8%) in the increased A/W subgroups. Common genetic variants explained approximately 10% of the heritability in the 2 subgroups. The increased A/W subgroup showed a strong and positive genetic correlation (SE) with BMI (0.53 [0.15]; P = 6.3 × 10-4), whereas the decreased A/W subgroup showed an inverse correlation (-0.28 [0.14]; P = .06). Furthermore, the decreased A/W subgroup had a higher polygenic risk for increased BMI (odds ratio [OR], 1.18; 95% CI, 1.12-1.25; P = 1.6 × 10-10) and levels of CRP (OR, 1.08; 95% CI, 1.02-1.13; P = 7.3 × 10-3) and leptin (OR, 1.09; 95% CI, 1.06-1.12; P = 1.7 × 10-3).The phenotypic associations between atypical depressive symptoms and obesity-related traits may arise from shared pathophysiologic mechanisms in patients with MDD. Development of treatments effectively targeting immunometabolic dysregulations may benefit patients with depression and obesity, both syndromes with important disability.
TCT-419 Long-term clinical outcomes of patients presenting with in-stent restenosis after drug-eluting stent implantation for unprotected left main coronary artery. A pooled analysis of the ISAR-LEFT MAIN and ISAR-LEFT MAIN 2 randomized trials
Authors: Erion Xhepa, Sebastian Kufner, Salvatore Cassese, Robert Byrne, Michael Joner, Tareq Ibrahim, Gjin Ndrepepa, Klaus Tiroch, Marco Valgimigli, Ralph Toelg, Massimiliano Fusaro, Heribert Schunkert, Karl-Ludwig Laugwitz, Adnan Kastrati
Journal: Journal of the American College of Cardiology (2017)
Decommissioning care: The need for rigorous multifaceted evaluations of decisions to withdraw health services
Authors: Aziz Sheikh
Journal: PLoS Medicine (2017)

In the current issue of PLOS Medicine, Terry Haines and colleagues report on 2 trials undertaken in acute medical and surgical wards in Australia to study the highly topical question of whether withdrawing weekend allied health services leads to detrimental health outcomes [1].Their trials offer a clear answer to an important health policy question and, more importantly, also provide the first published example of the use of a novel "incremental removal and reinstatement" cluster randomised, noninferiority, stepped-wedge design that can help reframe deliberations on disinvestment of care.Instead of focusing on potential cost-cutting measures, these trials offer a more nuanced assessment of value-based care whilst simultaneously providing a rigorous, unbiased assessment of the impact of radical restructuring of healthcare provision.
Lung, Bladder, and Kidney Cancer Mortality 40 Years After Arsenic Exposure Reduction
Authors: Allan H Smith, Guillermo Marshall, Taehyun Roh, Catterina Ferreccio, Jane Liaw, Craig Steinmaus
Journal: JNCI Journal of the National Cancer Institute (2017)

Region II in northern Chile (population 442 570) experienced a sudden major increase in arsenic water concentrations in 1958 in the main city of Antofagasta, followed by a major reduction in exposure when an arsenic removal plant was installed in 1970. It provides a unique opportunity to study latency effects of exposure to arsenic, and this is the first study with mortality data up to 40 years after exposure reduction. We previously identified high mortality rates in Region II up to the year 2000. Here we present rate ratios (RRs) for Region II compared with all the rest of Chile from 2001 to 2010, and with unexposed Region V (population 1 539 852) for all years from 1950 to 2010. All statistical tests were one-sided. From 2001 to 2010, comparing Region II with the rest of Chile, lung and bladder mortality were still greatly elevated (RR = 3.38, 95% confidence interval [CI] = 3.19 to 3.58, P < .001 for lung cancer in men; RR = 2.41, 95% CI = 2.20 to 2.64, P < .001 for lung cancer in women; RR = 4.79, 95% CI = 4.20 to 5.46, P < .001 for bladder cancer in men; RR = 6.43, 95% CI = 5.49 to 7.54, P < .001 for bladder cancer in women). Kidney cancer mortality was also elevated (RR = 1.75, 95% CI = 1.49 to 2.05, P < .001 for men; RR = 2.09, 95% CI = 1.69 to 2.57, P < .001 for women). Earlier short latency acute myocardial infarction mortality increases had subsided. Lung, bladder, and kidney cancer mortality due to arsenic exposure have very long latencies, with increased risks manifesting 40 years after exposure reduction. Our findings suggest that arsenic in drinking water may involve one of the longest cancer latencies for a human carcinogen.
Somatostatin in bleeding oesophageal varices
Authors: S A Jenkins, I N Baxter
Journal: BMJ (1996)

county demanded that "swabs" be taken of all wards.Much reassurance was needed before they agreed to continue working * A patient colonised with methicillin resistant S aureus rang up in tears.Friends and relatives had refused to visit him and accused him of spreading a lethal infection.The patient had serious medical problems, and this was putting him under severe additional stress.Although the programme made many valid points about the increased pressure that these bacteria impose on hospitals, we fear that the overall image was distorted.The message that many of the public, and health care workers, received is that people colonised with these organisms are a danger to society and must be isolated, avoided, and labelled as unclean.This perception is erroneous and dangerous.Three years of work by one of us (JH) in educating nurses and other health care workers about a rational policy regarding methicillin resistant S aureus has been at least partly undermined.The producers of the programme should think hard about the message they have impressed on the public: stories about "doomsday killer bugs" may make good copy, but they cause much needless fear, suspicion, and panic.
Oncogenetic mutations combined with MRD improve outcome prediction in pediatric T-cell acute lymphoblastic leukemia
Authors: Arnaud Petit, Amélie Trinquand, Sylvie Chevret, Paola Ballerini, Jean-Michel Cayuela, Nathalie Grardel, Aurore Touzart, Benoit Brethon, Hélène Lapillonne, Claudine Schmitt, Sandrine Thouvenin, Gerard Michel, Claude Preudhomme, Jean Soulier, Judith Landman-Parker, Guy Leverger, Elizabeth Macintyre, André Baruchel, Vahid Asnafi
Journal: Blood (2017)
Pigeon tick bite: A neglected cause of idiopathic nocturnal anaphylaxis
Authors: G. Rolla, E. Heffler, M. Boita, V. Doyen, M. Mairesse, M. Cvackova, S. Debarbieux, J. Kleine‐Tebbe, M. Ollert, M. Raulf, A. J. Bircher, C. Hilger
Journal: Allergy (2017)

Anaphylaxis is a serious systemic allergic reaction with rapid onset and potentially life-threatening. We report in detail a case of severe nocturnal anaphylaxis due to pigeon tick bite showing the diagnostic value of the extract and the recombinant allergen in the diagnostic procedures (basophil activation test, IgE immunoblot, and experimental ImmunoCAP). Apart from the presented case, we describe that during the last 10 years, we have collected 28 cases of allergy to Argas reflexus from several European countries. We suspect that this allergy is underdiagnosed because of the lack of diagnostic reagents. Because of the growing number of pigeons in Middle and Southern Europe cities, some cases of idiopathic anaphylaxis could potentially be caused by A. reflexus in those countries. The identification of pigeon ticks as a trigger of anaphylaxis would greatly improve medical care and advice for these patients as the parasite can be exterminated by eradication measures to avoid further incidents.
Aumento del número de infecciones gonocócicas identificadas por la red RENAGO
Authors: V Goulet, P Sednaoui, A Laporte, C Billy, J C Desenclos
Journal: Eurosurveillance (2000)

En Francia, la vigilancia de las enfermedades de transmision sexual (ETS) se fundamenta, principalmente, en las declaraciones de los laboratorios puesto que las ETS no figuran entre las enfermedades declaradas por los medicos (1). La red RENAGO (Red Nacional de Vigilancia de Infecciones Gonococicas; Reseau National du Gonocoque) se establecio en 1986 para monitorizar las tendencias nacionales de las infecciones gonococicas y estudiar la sensibilidad de Neisseria gonorrhoea a los antibioticos. Hasta 1992, la red constaba de unos 100 laboratorios y desde 1993 ha incluido otros 200; en ese ano, la red se amplio con la inclusion de laboratorios especializados (laboratorios que colaboran con clinicas antivenereas o con medicos especialistas en ETS).
Comparing The Ease Of Use, Preference And Satisfaction Of Accuhaler/Diskus And Elpenhaler In Patients With Asthma Or Chronic Obstructive Pulmonary Disease
Authors: Job J.A.M. van der Palen, P. van der Valk, M. Goosens, K. Groothuis-Oudshoorn, M. Brusse-Keizer
Journal: American Journal of Respiratory and Critical Care Medicine (2013)
Administering xCT Inhibitors Based on Circadian Clock Improves Antitumor Effects
Authors: Fumiyasu Okazaki, Naoya Matsunaga, Kengo Hamamura, Kayoko Suzuki, Takaharu Nakao, Hiroyuki Okazaki, Masahiko Kutsukake, Shiro Fukumori, Yasuhiro Tsuji, Hideto To
Journal: Cancer Research (2017)

Clock genes encoding transcription factors that regulate circadian rhythms may inform chronomodulated chemotherapy, where time-dependent dose alterations might affect drug efficacy and reduce side effects. For example, inhibiting the essential cystine transporter xCT with sulfasalazine induces growth arrest in cancer cells. Although the anticancer effects of sulfasalazine have been studied extensively, its effects on transcriptional control of xCT expression have not been studied. Here, we show that sulfasalazine administration during the period of increased xCT expression improves its anticancer effects and that the Clock gene itself induces xCT expression and regulates its circadian rhythm. Our findings highlight the clinical potential of chronomodulated chemotherapy and the importance of xCT-mediated transcriptional regulation in the utility of such strategies. Cancer Res; 77(23); 6603-13. ©2017 AACR.
OA02.01 Comparison of iRECIST to RECIST1.1 for Following Response to Anti-PD1 Therapy in Patients with Non-Small Cell Lung Cancer (NSCLC)
Authors: S. Katz, M. Hammer, S. Bagley, C. Aggarwal, J. Bauml, A. Nachiappan, C. Simone, C. Langer
Journal: Journal of Thoracic Oncology (2017)
Abstract 76: Clinical Usefulness Of Serum Procalcionin Level In Kawasaki Disease Children.
Authors: Hee Joung Choi, Tae Chan Kwon
Journal: Circulation (2015)

Purpose: Procalcitonin (PCT) is one of acute phase reactants such as C-reactive protein (CRP), and is likely to elevate in systemic inflammation, especially bacterial infection. As we know, the CRP level rise in the patients with high fever including Kawasaki disease (KD) and bacterial infection. So we investigated the clinical usefulness of serum PCT level in Kawasaki disease (KD), which is a systemic inflammation caused by vasculitis. Method: From August 2013 to June 2014, a total 336 patients were studied serum PCT level during hospitalization. We enrolled 41 patients of KD, 83 patients with viral infection, and 21 patients with bacterial infection. Result: The patients with KD had significantly higher mean age (24.4±18.1 months), mean body weight (12.1±3.9 Kg), and mean duration of fever prior to admission (4.4±1.8 days) than other patients (p&lt;0.05). The serum PCT level, white blood cell (WBC) and platelet count, neutrophil proportion, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were significantly higher in KD patients than viral infection patients (p&lt;0.05). Although not statistically significant, the serum PCT level was lower in KD patients than bacterial infection patients, whereas the CRP was higher in KD patients than bacterial infection patients. No significant difference in serum PCT level was showed between complete KD patients and incomplete KD patients. Also there was no significant difference in serum PCT level between responders to an initial intravenous immunoglobulin treatment and nonresponders. Conclusion: Serum PCT level may help to differentiate KD from viral infection, but we did not find a significant difference in PCT level between KD and bacterial infection. And the utility of PCT level as clinical marker in KD may be limited.
The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure
Authors: Antoni Bayes-Genis, Julio Núñez, Faiez Zannad, João Pedro Ferreira, Stefan D. Anker, John G. Cleland, Kenneth Dickstein, Gerasimos Filippatos, Chim C. Lang, Leong L. Ng, Piotr Ponikowski, Nilesh J. Samani, Dirk J. van Veldhuisen, Aeilko H. Zwinderman, Marco Metra, Josep Lupón, Adriaan A. Voors
Journal: Journal of the American College of Cardiology (2017)
TCT-569 In-Stent Restenosis Lesion Morphology Related to New Stent Underexpansion As Evaluated by Optical Coherence Tomography
Authors: Dong Yin, Gary Mintz, Lei Song, Tetsumin Lee, Ajay Jayant Kirtane, Manish Parikh, Jeffrey W. Moses, Khady Fall, Allen Jeremias, Fernando Sosa, Elizabeth Haag, Ziad Ali, Richard Shlofmitz, Akiko Maehara
Journal: Journal of the American College of Cardiology (2017)
TCT-168 TIcaGrEloR and ABSORB Bioresorbable Vascular Scaffold implantation for recovery of vascular function after successful Chronic Total Occlusion recanalization
Authors: Salvatore Brugaletta, Josep Gomez Lara, Juan Caballero-Borrego, Luis Ortega-Paz, Luis Teruel Gila, Miriam Jimenez, Rafael Romaguera, Vicente Alcalde Martinez, Marcos Ñato, Eduardo Molina, Joan Antoni Gomez-Hospital, Concepcion Correa Vilchez, Angel Cequier, Manel Sabate
Journal: Journal of the American College of Cardiology (2017)
Trichinellose humaine à Trichinella britovi dans le sud de la France après consommation de viande de sanglier congelée
Authors: M Gari-Toussaint, N Tieulié, J L Baldin, J Dupouy-Camet, P Delaunay, J G Fuzibet, Y Le Fichoux, E Pozio, P Marty
Journal: Eurosurveillance (2005)

Six patients ont ete contamines par Trichinella britovi dans le sud de la France apres avoir consomme de la viande de sanglier congelee a -35°C pendant 7 jours. L’examen microscopique d’un echantillon de muscle congele a permis de mettre en evidence la presence de rares larves encapsulees de Trichinella , identifiees comme appartenant a l’espece T. britovi. Des regles prophylactiques individuelles s'imposent pour les consommateurs de viande de sanglier, telles que la cuisson suffisante de la viande (au minimum un chauffage a cœur a 65°C pendant au moins une minute) conformement aux recommandations de la Commission Internationale de la Trichinellose, ou au moins quatre semaines de congelation a - 20°C.
TCT-757 Culprit Lesion Composition in Patients with ST-segment Elevation Myocardial Infarction assessed by Optical Coherence Tomography
Authors: Kirstine Hansen, Lisbeth Antonsen, Akiko Maehara, Michael Maeng, Julia Ellert, None lars jakobsen, Niels Holm, Ole Ahlehoff, Troels Thim, Karsten Veien, Christian Oliver Fallesen, Evald Christiansen, Lisette Okkels Jensen
Journal: Journal of the American College of Cardiology (2017)
TCT-634 Multivessel Disease in STEMI patients: A meta-analysis comparing complete vs. incomplete percutaneous revascularization
Authors: Hector Garcia-Garcia, Alexandre Hideo-Kajita, Kayode Kuku, Solomon Beyene, Viana Azizi, Yael Meirovich, Gebremedhin Melaku, Ahn Bui, Aaphtaab Dheendsa, Echo Brathwaite, Sameer Desale, Michael Lipinski, Ron Waksman
Journal: Journal of the American College of Cardiology (2017)