tbuckley/cabot-search huggingface dataset:
NCOG-20. GENETIC MARKERS AND CLINICAL CHARACTERISTICS RELATED TO NEUROCOGNITIVE OUTCOMES OF PEDIATRIC BRAIN TUMOR PATIENTS
Authors: Cassie Kline-Nunnally, Erin Felton, Caleb Edwards, Heather Fullerton, Joseph Torkildson, Karen Gauvain, David Samuel, Sabine Mueller
Journal: Neuro-Oncology (2017)

Pediatric brain tumors affect more than 50,000 children in the US with nearly 5,000 new diagnoses annually. Although neurocognitive outcomes for this population show lower scores when compared to population means, there is great variability among individuals. In the current study, we aim to investigate the impact of cognition-related genes, KLOTHO, ApoE4, BDNF, COMT, and KIBRA, on neurocognitive outcomes in pediatric brain tumor patients. Utilizing an existing cohort of pediatric brain tumor patients from a diverse brain tumor population, we performed single nucleotide polymorphism (SNP) genotyping for KLOTHO, ApoE4, BDNF, COMT, and KIBRA. Neurocognitive evaluations were completed for these same patients at baseline and follow-up intervals, using validated, computer-based CogState batteries. Mixed modeling was done to correlate individual SNPs with neurocognitive outcomes over time, adjusting a priori for time from radiation, age at diagnosis, hydrocephalus, seizures, chemotherapy/radiation exposure, sex, tumor type, and tumor location. Lowess smoothing regression was done to assess the impact of individual genes SNPs on neurocognition. Ninety-seven patients were included in the analyses (54 males; median age at diagnosis 7 years). Medulloblastoma was the most frequent diagnosis (29%). Time from radiation, hydrocephalus at diagnosis, and seizures at diagnosis most consistently impacted neurocognition across neurocognitive test batteries (as based on statistical significance at p-value<0.05 across gene SNPs and testing batteries). Using smoothing regression, ApoE4 carrier status consistently negatively impacted neurocognitive function over time, as seen by decreasing neurocognitive scores over time across all batteries. Time from radiation and hydrocephalus and/or seizures at diagnosis illustrated statistically significant impacts on neurocognitive outcomes of pediatric brain tumor patients. KLOTHO, BDNF, COMT, and KIBRA did not appear to impact neurocognition; however, ApoE4 warrants further investigation as a possible predictor of neurocognitive outcomes. Our study highlights factors that may be of importance in anticipatory guidance and potentially, treatment-planning for children with brain tumors.
P2.03-016 Clinical Utility of Liquid Biopsy for Detecting EGFR T790M Mutation Is Very Limited
Authors: T. Sakamoto, K. Yamane, N. Tanaka, M. Yanai, H. Izumi, K. Yamaguchi, K. Takeda, H. Makino, T. Igishi, A. Yamasaki, E. Simizu
Journal: Journal of Thoracic Oncology (2017)
Effect of an antimicrobial stewardship programme on antimicrobial utilisation and costs in patients with leukaemia: a retrospective controlled study
Authors: M. So, M.M. Mamdani, A.M. Morris, T.T.Y. Lau, R. Broady, U. Deotare, J. Grant, D. Kim, A.D. Schimmer, A.C. Schuh, S. Shajari, M. Steinberg, C.M. Bell, S. Husain
Journal: Clinical Microbiology and Infection (2017)
Health-related quality-of-life results for pembrolizumab versus chemotherapy in advanced, PD-L1-positive NSCLC (KEYNOTE-024): a multicentre, international, randomised, open-label phase 3 trial
Authors: Julie R Brahmer, Delvys Rodríguez-Abreu, Andrew G Robinson, Rina Hui, Tibor Csőszi, Andrea Fülöp, Maya Gottfried, Nir Peled, Ali Tafreshi, Sinead Cuffe, Mary O'Brien, Suman Rao, Katsuyuki Hotta, Jin Zhang, Gregory M Lubiniecki, Anne C Deitz, Reshma Rangwala, Martin Reck
Journal: The Lancet Oncology (2017)
Identification and management of Shigella infection in children with diarrhoea: a systematic review and meta-analysis
Authors: Kirkby D Tickell, Rebecca L Brander, Hannah E Atlas, Jeffrey M Pernica, Judd L Walson, Patricia B Pavlinac
Journal: The Lancet Global Health (2017)

Shigella infections are a leading cause of diarrhoeal death among children in low-income and middle-income countries. WHO guidelines reserve antibiotics for treating children with dysentery. Reliance on dysentery for identification and management of Shigella infection might miss an opportunity to reduce Shigella-associated morbidity and mortality. We aimed to systematically review and evaluate Shigella-associated and dysentery-associated mortality, the diagnostic value of dysentery for the identification of Shigella infection, and the efficacy of antibiotics for children with Shigella or dysentery, or both.
P1.15-011 Longitudinal Mutation Monitoring in Plasma Without Matching Tumor Tissue by Deep Sequencing in Small Cell Lung Cancer (SCLC)
Authors: A. Rosenthal, M. Lange, S. Beckert, B. Hinzmann, C. Woestmann, B. Wehnl, M. Schneider, M. Meister, M. Thomas, T. Muley, A. Warth, S. Froehler, J. Palma, F.J. Herth
Journal: Journal of Thoracic Oncology (2017)
Analysis of clinical outcomes according to mutation subtype in EGFR-positive advanced non-small cell lung cancer (aNSCLC) patients treated with EGFR Tyrosine Kinases Inhibitors (TKIs) as first line
Authors: A. Veccia, S. Girlando, M. Dipasquale, M. Barbareschi, O. Caffo
Journal: Annals of Oncology (2017)
P1.06-040 Home-Based Pulmonary Rehabilitation in Advanced Non-Small Cell Lung Cancer Patients Treated by Oral Targeted Therapy: A Feasibility Study
Authors: Caroline Pagniez, Cecile Olivier, Alexandre Olislagers, Sophie Peres, Eric Wasielewski, Anne Baranzelli, Marie-Capucine Willemin, Xavier Dhalluin, Alexis Cortot, Anne Hoorelbeke, Arnaud Scherpereel
Journal: Journal of Thoracic Oncology (2017)
Importation d’un cas de rage canine en Aquitaine : recherche et prise en charge des contacts à risque, août 2004-mars 2005
Authors: V Servas, A Mailles, D Neau, C Castor, A Manetti, E Fouquet, J M Ragnaud, H Bourhy, M C Paty, N Melik, J Astoul, F Cliquet, M P Moiton, C François, M Coustillas, J C Minet, P Parriaud, I Capek, L Filleul
Journal: Eurosurveillance (2005)

En aout 2004, un diagnostic de rage etait confirme chez un chiot importe illegalement du Maroc a Bordeaux (France). Face au grand nombre de personnes et d’animaux ayant pu etre en contact avec le chiot, un important dispositif de recherche a ete mis en place et une alerte internationale a ete lancee pour retrouver et prendre en charge les contacts a risque. Cent quatre vingt sept personnes ont recu un traitement post-exposition dont 8 par serotherapie, et 57 animaux ayant eu un contact certain avec le chiot ont ete analyses. Six mois apres la mort de l’animal enrage aucune personne traitee ne presentait de signe de rage et aucun cas secondaire animal n’etait declare. La gestion de cette crise a mis en evidence le role indispensable d’un systeme d’alerte rapide a l’echelle europeenne. L’application stricte du controle sanitaire des animaux introduits dans les pays de l’UE est essentielle ainsi que l’information des voyageurs se rendant en zone d’enzootie rabique.
OA 13.06 Co-Expression of IDO1 and PD-L1 Indicates More Aggressive Features of Lung Adenocarcinoma
Authors: Y. Kozuma, K. Takada, G. Toyokawa, K. Kohashi, M. Shimokawa, F. Kinoshita, T. Matsubara, N. Haratake, S. Takamori, T. Akamine, F. Hirai, T. Tagawa, Y. Oda, Y. Maehara
Journal: Journal of Thoracic Oncology (2017)
P2.02-048 Survival Correlation Between TP53 Gene and PD-L1 Tumor Expression in Resected Non-Small Cell Lung Carcinoma
Authors: J. Sui, M.Y. Teo, S. Twomey, S. Rafee, J. Mcfadden, K. Gately, M. Barr, S. Gray, B. Hennessy, K. O’Byrne, S. Cuffe, S. Finn
Journal: Journal of Thoracic Oncology (2017)
Strategy of monitoring metastatic breast cancer (M-MBC) in clinical practice: more or less intensive?
Authors: M.G. Vitale, M. Bonotto, L. Gerratana, D. Basile, M. Bartoletti, G. Pelizzari, V. Fanotto, C. Lisanti, C. Bozza, M. Cinausero, D. Iacono, E. Poletto, S. Barban, I. Mansutti, A.M. Minisini, S. Russo, C. Andreetta, M. Mansutti, G. Fasola, F. Puglisi
Journal: Annals of Oncology (2017)
Abstract 19449: Upregulation of Cofilin-2 in Mouse Models Of DCM - Implications for SRF Signaling
Authors: Phillip Hoppe, Elisa Zille, Johanne Gantenberg, Matthias Eden, Christian Kuhn, Norbert Frey, Derk Frank
Journal: Circulation (2015)

The dilated cardiomyopathy (DCM) is a major cause for heart failure. A causative genetic background is suspected in up to 50% of all DCM cases. However, the underlying molecular pathways remain incompletely understood. Here we analyze a calsarcin-1 deficient (CS1ko) mouse line as a model for DCM. These mice showed strong upregulation of fetal genes (e.g., Nppa, Nppb ) and the calcineurin-dependent gene Rcan1.4. Interestingly, we could not detect any signes of hypertrophy. In addition, there was no increase of fibrosis in CS1ko mice compared to wildtype controls. A screening experiment revealed upregulation of Cofilin2 (Cfl2), an actin depolymerisation factor and member of the ADF/Cofilin family, in Cs1ko mice (2.6-fold, p&lt;0.002), whereas its inactive, phosphorylated form (Ser3) remained unchanged. We also found increased amounts of Cfl2 in MLP-/- (1,8-fold p&lt;0.05) and Calcineurin TG mice (2.7-fold p&lt;0.01) suggesting a general role for Cfl2 in DCM. As Cfl2 is a known regulator of actin dynamics we investigated the role of Cfl2 in SRF signaling. Using an SRF-responsive luciferase reporter, overexpression of Cfl2 together with RhoA as activator of SRF signaling lead to an increase of SRF activity in C2C12 myoblasts (14-fold vs. 5.8-fold with RhoA alone, p&lt;0.001). SiRNA-mediated knockdown of Cfl2 yielded opposite effects (0.96-fold vs. 4.6-fold, p&lt;0.001). In the heart Cfl2 is predominantly expressed in cardiac myocytes as compared to fibroblasts. Overexpression of Cfl2 in cardiomyocytes (NRVCM) revealed an increase of Nppa and Nppb , which could be further increased by co-stimulation with phenylephrine (PE). In contrast to these findings, cell size analysis revealed a Cfl2-mediated decrease in cell size with and without PE, while knockdown of Cfl2 did not influence cellular hypertrophy. Taken together, our data imply a role for Cfl2 in the pathogenesis of DCM. Cs-1ko mice show a dilated phenotype, strong upregulation of the fetal gene program without a change in cell size. This correlates with the findings of overexpression of Cfl2 in NRVCM. Furthermore, increased Cfl2 levels induce SRF activity with potential influence on cardiomyocyte function. Further analyses are required to delineate the involved molecular pathways.
Control versus cognition: the changing paradigm of adjuvant therapy for resected brain metastasis
Authors: Vinai Gondi, Minesh P Mehta
Journal: Neuro-Oncology (2017)

Twenty years ago, Patchell and colleagues 1 demonstrated that whole-brain radiotherapy (WBRT) mitigates relapse both in the surgical bed and elsewhere in the brain and prevents death from neurologic causes in patients with resected brain metastasis.Therefore, postoperative WBRT became the standard of care.With advances in surgical technique, some have questioned the need for WBRT.Emerging data have highlighted the adverse cognitive effects of WBRT, leading to trials of postoperative stereotactic radiosurgery (SRS), hypothesized to yield equivalent local control but higher risk of distant brain relapse compared with WBRT, and in theory providing an appropriate balance between intracranial control and cognition.Mahajan and colleagues 2 reported on a single-institution randomized trial of observation versus SRS for patients who underwent resection of 1-3 brain metastases.SRS yielded no overall survival or neurologic death benefit but reduced the 12-month surgical bed relapse rate from 57% to 29% (P = 0.015), confirming that adjuvant SRS yields modest surgical bed control benefit without improving survival.Brown and colleagues 3 reported results from a multi-institutional phase III trial (N107C) of SRS versus WBRT for patients undergoing resection of one brain metastasis.This trial was more reflective of community-based neurosurgical and radiosurgical practices.There was no survival difference between the modalities.WBRT yielded a 20% improvement in 12-month surgical bed control (SRS 60% vs WBRT 80%, P = 0.00068).Overall intracranial control (37% vs 72% at 12 months, P < 0.0001) and median time to any intracranial progression (6.4 vs 27.5 mo) also favored WBRT.The trade-off of these benefits from WBRT was an approximate 3-week shortening in median cognitive deterioration-free survival (3.7 mo for SRS vs 3 mo, P = 0.00068) and a 33% increase in 6-month cognitive deterioration (one standard deviation decline in at least one cognitive test).Collectively, these studies suggest that following resection for brain metastasis, SRS relative to observation yields no overall survival or neurologic death benefit but diminishes surgical bed failure; and, relative to WBRT, does not improve survival, decreases surgical bed control and time to intracranial failure, but improves time to and incidence of cognitive decline.Therefore, treatment selection requires a comprehensive and balanced discussion of trade-offs with patients.Overall survival
P3.02-047 Testing EGFR and ALK in Large Cell Neuroendocrine Carcinoma of the Lung. Looking for Biological Features in Rare Tumors
Authors: T. García Manrique, A.M. Vallejo Benítez, E. Rodriguez Zarco, A. García Escudero, D. Vicente Baz
Journal: Journal of Thoracic Oncology (2017)
La vigilancia del linfogranuloma venéreo rectal en Francia, 2004-2005
Authors: M Herida, B de Barbeyrac, P Sednaoui, C Scieux, N Lemarchand, G Kreplak, M Clerc, J Timsit, V Goulet, J C Desenclos, C Semaille
Journal: Eurosurveillance (2006)

El linfogranuloma venereo (LGV) es una infeccion de transmision sexual (ITS) causada por las cepas de Chlamydia trachomatis pertenecientes a lo genotipo L1, L2 o L3. 
En enero de 2004, se publico una alerta sobre un brote de LGV en hombres homosexuales en los Paises Bajos. Los primeros casos de LGV rectal en Francia se diagnosticaron en marzo de 2004, y la vigilancia centinela de esta enfermedad se implemento en abril de 2004. 
La mayoria de los centros participantes estaban situados en Paris o Burdeos. La vigilancia incluia solamente los casos confirmados de LGV rectal. Se mandaron muestras rectales PCR positivas a C. trachomatis al Centro nacional de referencia de Chlamydia para su genotipado. Los datos epidemiologicos basicos proporcionados por los clinicos y los resultados de la genotipificacion se enviaron al Institut de veille sanitaire (InVS), donde se registraron de forma anonima. 
Un numero total de 328 cepas rectales de C. trachomatis aisladas en varones se genotiparon antes de final de diciembre de 2005, y 244 (74%) de ellas pertenecian al genotipo L2. No fue identificado ningun genotipo L1 o L3. 
Cuarenta y seis casos fueron diagnosticados retrospectivamente. La edad mediana de los pacientes afectados por el LGV era 39 anos. Se conocia el estatus VIH en 96 pacientes : 82/96 (85%) estaban co-infectados por el VIH. La mayoria de los casos de LGV se diagnosticaron en la region de Paris (92%). Entre las cepas no-LGV (26%) de C. trachomatis, los genotipos Da y G fueron los mas frecuentes. 
Al igual que para la sifilis recientemente, la emergencia del LGV en Europa afecta principalmente los hombres homosexuales infectados por el VIH. El cribado y el tratamiento de las ITS deberian incluirse en el seguimiento clinico de todos los varones homosexuales infectados por el VIH.
Um serviço médico de plantão como base para a vigilância sentinela da gripe
Authors: J Turner, H Kelly
Journal: Eurosurveillance (2005)

A vigilância da gripe nos paises da Uniao Europeia comprende uma rede sentinela de medicos gerais que declaram os casos de sindromes gripais (Influenza-like illness, ILI), o recolho de amostras para as analises virologicas e as declaracoes de diagnosticos de gripe enviadas pelos laboratorios. Em Victoria, Australia, existe um sistema semelhante de vigilância sentinela, as ILI que sao definidas por occurencia de febre, tosse e cansaco, e as temporadas de gripe que sao definidas por limiares. Portanto, a coordinacao dos medicos gerais sentinela pode ser muito cara, em tempo e dinheiro. Durante as duas ultimas temporadas gripais, um servico de medicos de plantao foi utilizado como sistema sentinela para a vigilância da gripe. Nao se conhece outro sistema egual em nenhuma parte do mundo. As comparacoes retrospectivas e prospectivas mostraram que os padroes de vigilância de ILI dos medicos gerais sentinela sao semelhantes aos do servico de medicos de plantao. Gracas a sua rapidez e flexibilidade, variedade de pacientes e a sua distribuicao geografica, a vigilância feita por um servico de medicos de guarda pode substituir a vigilância sentinela, e alem disso, desempenhar um papel importante no reconhecimento dos padroes de doencas emergentes. Isto muito provavelmente seja certo nao so em Australia, mas tambem nos paises da Uniao Europeia.
P1.03-041 Exploitation of the Cancer Stem Cell Marker ALDH1 Within the Vitamin a/Retinoic Acid Axis Promotes Re-Sensitization of Cisplatin Resistant NSCLC
Authors: L. Mac Donagh, S. Gray, M. Gallagher, B. Ffrench, C. Gasch, S. Finn, S. Cuffe, K. O’Byrne, M. Barr
Journal: Journal of Thoracic Oncology (2017)
OA 05.02 Osimertinib vs SoC EGFR-TKI as First-Line Treatment in Patients with EGFRm Advanced NSCLC (FLAURA): Plasma ctDNA Analysis
Authors: J. Gray, I. Okamoto, V. Sriuranpong, J. Vansteenkiste, F. Imamura, J.S. Lee, Y. Pang, M. Cobo, K. Kasahara, R. Hodge, B. Lentrichia, S. Dearden, S. Ramalingam
Journal: Journal of Thoracic Oncology (2017)
EXTH-73. MUTANT ISOCITRATE DEHYDROGENASE EXPRESSION CORRELATES WITH SENSITIVITY TO THE HISTONE DEACETYLASE INHIBITOR BELINOSTAT POTENTIALLY THROUGH INCREASED APOPTOSIS
Authors: Tony Zhang, Chi-Ming Chang, Younghyoun Yoon, Hyunsuk Shim, Hui-Kuo Shu
Journal: Neuro-Oncology (2017)

Mutant isocitrate dehydrogenase 1 (mtIDH1) is commonly found in adult gliomas, particularly the lower grade variety, and appears predictive of therapeutic response. Despite better outcomes in tumors harboring these mutations, mtIDH1, through production of the onco-metabolite 2-hydroxyglutarate (2HG), appears sufficient to drive astrocyte transformation potentially through alterations in the epigenetic state of tumor cells. Inhibitors of histone deacetylases (HDACis) are drugs that affect the epigenetic status potentially reverting chromatin structure of tumor cells to a non-transforming configuration. Therefore, we hypothesized that gliomas that harbor mtIDH1 may show enhanced response to epigenetic drugs such as HDACis. To test this hypothesis, mtIDH1 was exogenously expressed in an immortalized normal human astrocyte line as well as the LN229 glioma cell line. Both constitutive and inducible expression of mtIDH1 was accomplished in these lines with confirmation of expression by western blot and production of 2HG in the media by mass spectrometry. Treatment with the HDACi belinostat (BeleodaqTM, Spectrum Pharmaceuticals) readily increases acetylation of histone H4 and tubulin in our cell lines. Moreover, this drug can cross the blood-brain barrier and we have demonstrated its single agent activity in a rodent orthotopic glioma model. Using our isogenic cell lines differing in mtIDH1 expression, we found by MTS assay that growth inhibition with belinostat treatment was significantly more pronounced when mtIDH1 was present. In assessing potential mechanisms for differential response to belinostat, we found higher drug-induced apoptosis by Annexin V assay in our cell lines expressing mtIDH1. Furthermore, the induction of caspase activity by belinostat was consistently 2-fold higher as measured by colorimetric assay in the mtIDH1 expressors compared with corresponding controls. Our data suggest that gliomas with mtIDH1 may be particularly sensitive to HDACis such as belinostat. Clinical testing of this drug in brain tumors harboring mtIDH1 such as lower grade gliomas may be warranted.
Genotyping Natural Killer Immune Checkpoints to Discover Biomarkers of Response
Authors: Nai-Kong Cheung, Katharine C. Hsu
Journal: Clinical Cancer Research (2017)

Abstract Immune checkpoints have been a focus of immunotherapy in the recent decade. Killer cell immunoglobulin-like receptors (KIR) and their cognate human leukocyte antigen (HLA) class I ligands have evolved as checkpoints to ensure self-tolerance of natural killer cells. Both KIR and HLA genetic profiles are potential biomarkers of immunotherapy outcome. Clin Cancer Res; 24(1); 3–5. ©2017 AACR. See related article by Erbe et al., p. 189
Evolution épidémiologique des infections à méningocoque en Espagne, 1989-1997
Authors: S Mateo, R Cano, C García
Journal: Eurosurveillance (1997)

Dans les annees 1980, en Espagne, les infections a meningocoque se caracterisaient par une predominance du serotype B (1). Mais, depuis le debut des annees 1990, un nombre croissant de souches de serotype C a ete isole dans certaines localites a l'ouest du pays (2), sans etre accompagne au debut d'une hausse de l'incidence.
Ponto da situação pela OMS sobre a gripe tipo A (H5N1) em Hong Kong
Authors: D Lavanchy
Journal: Eurosurveillance (1998)

Os virus da gripe dividem-se em tipos A, B, e C, sendo o tipo A ainda dividido em subtipos. 
Os tipos A e B circulam nas populacoes humanas e modificam-se constantemente, originando a necessidade de, todos os anos, modificar as vacinas. Por vezes, surge um novo virus da gripe ao qual ninguem e imune, porque nao houve, anteriormente, nenhuma exposicao a ele.
Sharing long term follow-up of breast cancer survivors with family physician: a province of Lecco experience
Authors: F. Villa, I. Colombo, A. Crippa, G. De Martini, M. Lafranconi, S. Dell'Oro, I. Vittimberga, J. Arnoffi, F.M. Guida, S. Villa, M. Anghilieri, C. Viganò, P. Ferrando, G. De Nittis, V. Valsecchi, A. Ardizzoia
Journal: Annals of Oncology (2017)
TMIC-33. POTENTIAL OF MAGNETIC HYPERTHERMIA TO STIMULATE AN IMMUNE RESPONSE IN GLIOBLASTOMA
Authors: Thomas Carter, Giulia Agliardi, Matthew Ellis, Fang-Yu Lin, Clare Jones, Mathew Robson, Angela Richard-Londt, Paul Southern, Quentin Pankhurst, Rafael T M de Rosales, Cordula Gruettner, R Barbara Pedley, Tammy Kalber, Sebastian Brandner, Paul Mulholland, Kerry Chester
Journal: Neuro-Oncology (2017)

Glioblastoma, the most common primary adult brain malignancy, is an aggressive tumour with a median survival of around one year. Despite decades of research there has been minimal improvement in prognosis and innovative new treatments are urgently required. We aimed to focus on the tumour microenvironment (TME) and designed a novel therapeutic approach, using nanotechnology to achieve in-situ tumour vaccination mediated by localised hyperthermia, in combination with immune checkpoint inhibition. In-situ heating was generated using superparamagnetic iron-oxide nanoparticles (SPIONs) stimulated by an alternating magnetic field (AMF). In-vivo experiments utilised the immunocompetent GL261 glioblastoma model and included: (i) Intratumoural injection of 89Zr-labelled SPIONs to evaluate in-vivo fate using PET imaging; (ii) Evaluation of SPION in-vivo heating ability using thermal imaging; (iii) Tumour growth and timed immunohistochemical (IHC) response analysis and (iv) Fluorescence activated cell sorting (FACS) analysis of the tumour infiltrating lymphocyte (TIL) populations following treatment. SPIONs remained within the tumour following injection and retained ability to generate AMF-induced heat for at least 72 hours post injection. Digital image analysis of IHC demonstrated a specific, localised, heat-shock protein response following hyperthermia. Furthermore, tumour growth inhibition was observed up to one week following treatment. Finally, tumour FACS analysis revealed an influx of activated cytotoxic T-cells alongside an increase in proliferating regulatory T-cells following treatment. SPION mediated hyperthermia is achievable in-vivo and can generate TME changes suggestive of an anti-tumour immune response. Future analysis of immune checkpoint expression in the TIL populations will be used to guide combinatorial approaches.
Proton therapy patterns of care among pediatric and adult patients with CNS tumors
Authors: Yolanda D Tseng, William Hartsell, Henry Tsai, Shahed Badiyan, Chiachien J Wang, Carl Rossi, Rupesh Kotecha, Sujay Vora, Carlos Vargas, Gary Larson, Lia M Halasz
Journal: Neuro-Oncology (2018)