tbuckley/cabot-search huggingface dataset:
QLIF-02. NEURO-ONCOLOGY BURNOUT: IMPACT OF PROFESSIONAL STRESSORS AND JOB SATISFACTION
Authors: Alvina A Acquaye, Elizabeth Vera, Shlomit Yust-Katz, Barbara J O’Brien, Terri Armstrong
Journal: Neuro-Oncology (2017)

Burnout is prevalent among cancer care providers and has three dimensions: emotional exhaustion, depersonalization and low personal accomplishment. Exposure to professional stress and lack of satisfaction is associated with burnout. Professions within neuro-oncology work with a complex patient population with significant morbidity and mortality. The impact of identified stressors and satisfaction have not been previously explored in neuro-oncology professionals. The Neuro-Oncology Burnout and Career Satisfaction survey was completed by 326 healthcare professionals (physicians (72%), allied health professionals (16%) and basic scientists (10%)) via a web-based portal. Qualitative analysis was applied to explore identified stressors and satisfaction. Three predominant themes emerged on stressors: 1) work demands, 2) personal challenges in work/life balance and emotional intelligence, and 3) aspects of caring for brain tumor patients. Several factors including multiple demands, administrative burden, issues with peers/staff/administration and personal uncertainties contributed to the development of work demands (80%) as a common stressful theme. Each profession reported different stressful influencers, i.e. external funding for basic scientists, lack of support staff resonated with allied health and physicians endorsed lack of time to adhere to multiple demands. Job satisfaction included five identified areas in aspects of one’s position: research involvement, work atmosphere, personal aspects, patient interactions, and training of residents/medical students/fellows. Identified aspects associated with satisfaction included relationships with patient/families by direct care providers and family/patient gratitude while basic scientists identified research outcomes. The multiple factors contributing to stressful aspects of one’s position form a framework of interconnected patterns that could model risk factors associated with provider burnout. Understanding subjective concerns that exacerbate burnout and satisfaction provides a guide for future implementation of efficient strategies within organizations that can mitigate burnout and detect initial warning signs to target.
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression
Authors: Jeff W. Kwak, Jennifer Laskowski, Howard Y. Li, Maria V. McSharry, Trisha R. Sippel, Bonnie L. Bullock, Amber M. Johnson, Joanna M. Poczobutt, Alexander J. Neuwelt, Stephen P. Malkoski, Mary C. Weiser-Evans, John D. Lambris, Eric T. Clambey, Joshua M. Thurman, Raphael A. Nemenoff
Journal: Cancer Research (2017)

The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression. Here we report mechanistic insights into this association in multiple immunocompetent orthotopic models of lung cancer. After tumor engraftment, we observed systemic activation of the complement cascade as reflected by elevated levels of the key regulator C3a. Notably, growth of primary tumors and metastases was both strongly inhibited in C3-deficient mice (C3-/- mice), with tumors undetectable in many subjects. Growth inhibition was associated with increased numbers of IFNγ+/TNFα+/IL10+ CD4+ and CD8+ T cells. Immunodepletion of CD4+ but not CD8+ T cells in tumor-bearing subjects reversed the inhibitory effects of C3 deletion. Similarly, antagonists of the C3a or C5a receptors inhibited tumor growth. Investigations using multiple tumor cell lines in the orthotopic model suggested the involvement of a C3/C3 receptor autocrine signaling loop in regulating tumor growth. Overall, our findings offer functional evidence that complement activation serves as a critical immunomodulator in lung cancer progression, acting to drive immune escape via a C3/C5-dependent pathway.Significance: This provocative study suggests that inhibiting complement activation may heighten immunotherapeutic responses in lung cancer, offering findings with immediate implications, given the existing clinical availability of complement antagonists. Cancer Res; 78(1); 143-56. ©2017 AACR.
Asprosin is a centrally acting orexigenic hormone
Authors: Clemens Duerrschmid, Yanlin He, Chunmei Wang, Chia Li, Juan C Bournat, Chase Romere, Pradip K Saha, Mark E Lee, Kevin J Phillips, Mahim Jain, Peilin Jia, Zhongming Zhao, Monica Farias, Qi Wu, Dianna M Milewicz, V Reid Sutton, David D Moore, Nancy F Butte, Michael J Krashes, Yong Xu, Atul R Chopra
Journal: Nature Medicine (2017)
EPID-04. DETERMINING THE PRESENCE OF HUMAN CYTOMEGALOVIRUS PROTEINS IN GLIOBLASTOMA
Authors: Kayla Bassett, Nicholas Blondin
Journal: Neuro-Oncology (2017)

The objective of our study is to determine if human cytomeglovirus (HCMV) is present in glioblastoma multiforme (GBM) tumor samples in our patient population, using an immunohistochemistry (IHC) technique. The primary outcome will be assessing the proportion of GBM tumor samples that harbor HCMV proteins IE1 and pp65. GBM is the most common malignant brain tumor in adults. There is substantial controversy over whether HCMV is present in GBM, and if present, what role it may play in the disease. IE1 and pp65 are HCMV-specific viral proteins, and if present in human tissue, indicate the presence of HCMV. Prior studies on the detection of HCMV proteins in glioblastoma have yielded inconsistent results. 21 patients diagnosed with glioblastoma at our institution have been enrolled into the study. Tumor samples were available for testing from all patients. IHC tests for IE1 and pp65 proteins were performed using standard methodology in tumor and control samples. Among 21 GBM tumors, 6 (29%) were positive for pp65, and 1 (3%) was positive for both pp65 and IE1. The remainder of cases were negative. Testing for the presence of HCMV proteins in GBM is feasible in a community-based setting. HCMV proteins can be detected in some GBM tumors. The role of these proteins in disease pathogenesis is unclear. Further study of this finding is indicated.
Rapporto sul Sixth International Meeting of the European Laboratory Working Group on Diphtheria, Bruxelles, Belgio
Authors: S Lai, A Efstratiou
Journal: Eurosurveillance (2002)

Parallelamente alla recrudescenza della difterite osservata nell'Europa dell'Est negli ultimi dieci anni, si e potuta constatare l'apparizione di infezioni causate da ceppi di Corynebacterium diphtheriae non- tossigenici e di C. diphtheriae non-tossigenici, ma portatori del gene della tossina. Dato che questi ceppi possono manifestarsi come infezioni sintomatiche di diverso grado di gravita, conviene valutare il loro significato clinico ed epidemiologico. La persistenza di C. diphtheriae tossigenico e non-tossigenico in circolazione, insieme alla variabilita dei genotipi e dei biotipi, implica l'introduzione di misure innovative per vaccinare la popolazione. La misura piu efficace per proteggere i gruppi di popolazione attualmente piu vulnerabili (gli adulti) rimane quella di somministrare una dose di richiamo alla popolazione adulta. Inoltre, l'attuazione di un buon sistema di sorveglianza, una efficace profilassi antibiotica e un aggiornato programma vaccinale, devono andare di pari passo con il proseguimento degli studi sierologici che permettono di monitorare lo stato immunitario della popolazione. Le comunicazioni al Sixth International Meeting of the European Laboratory Working Group on Diphtheria, hanno fornito una panoramica della microbiologia e dell'epidemiologia della difterite nei nuovi stati indipendenti della ex Unione Sovietica. Hanno anche permesso una rassegna internazionale aggiornata degli aspetti epidemiologici, clinici e microbiologici.
Sorveglianza della prevalenza dell'HIV e dei comportamenti degli uomini che hanno rapporti sessuali con altri uomini a Barcellona, Spagna
Authors: K Pérez, A Rodes, J Casabona Barbarà
Journal: Eurosurveillance (2002)

Diversi studi su uomini che hanno rapporti sessuali con altri uomini hanno recentemente rivelato un aumento dell'incidenza dell'HIV e di infezioni sessualmente trasmesse, come pure di comportamenti a rischio. Ma l'ottimismo che riguarda i nuovi trattamenti antiretrovirali puo portare nel prossimo futuro a un maggiore rilassamento delle misure protettive.
NCOG-01. PATIENT-REPORTED COGNITIVE CONCERNS AND QUALITY OF LIFE IN BRAIN METASTASES
Authors: Nadine Richard, David Shultz, Normand Laperriere, Alejandro Berlin, Tatiana Conrad, Barbara-Ann Millar, Mark Bernstein, Paul Kongkham, Gelareh Zadeh, Kim Edelstein
Journal: Neuro-Oncology (2017)

While treatment options for brain metastases continue to evolve, prognosis remains poor for morbidity and survival. Quality of life (QOL) is increasingly emphasized and assessed via patient-reported outcomes. Although studies show most patients are cognitively impaired on objective testing, few have explored patients' subjective cognitive concerns in relation to other aspects of QOL. A cross-sectional sample of brain metastasis patients completed measures assessing subjective cognitive functioning in multiple domains as well as functional limitations, illness intrusiveness (i.e., interference in valued activities and relationships), existential distress, anxiety and depression. Seventy patients completed the survey; 40% were treated with SRS alone, 19% with WBRT±SRS, 7% with surgery and/or focal radiation only, and 34% had not yet received CNS-directed therapy. Patients ranged in age from 31-87; 64% were female. Prevalence of self-reported cognitive impairments varied by domain, with attention and processing speed most common (19% of patients each), followed by executive, memory and language functions (14, 11 and 9%). These cognitive concerns did not relate to patients' age or differ by sex, but were associated with symptoms of anxiety (r's = 0.365 to 0.527, p's < .005), depression (r's = 0.508 to 0.650, p's < .001), existential distress (r's = 0.338 to 0.541, p's < .01) and illness intrusiveness (r's = 0.333 to 0.442, p's < .05). Processing speed and attentional deficits were additionally linked to limitations in instrumental activities (r's = 0.262 and 0.272, p's < .05). Patients who had undergone surgery and/or focal radiation reported greater cognitive impairment than other CNS treatment groups. Results show a significant association between brain metastasis patients' subjective cognitive concerns and QOL, and an effect of CNS treatment on patient-reported cognitive outcomes. These data may be used to develop supportive care initiatives for brain metastasis patients.
P3.03-016 Morphometric Genotyping Identifies Lung Cancer Cells Harboring Target Mutations; Cell-CT® Platform Detects Gene Abnormalities
Authors: A. Nelson, M. Meyer, D. Sussman, R. Katdare, C. Presley, F. Lakers, C. Hamilton, D. Wilbur, R. Mastrangelo, M. Doherty
Journal: Journal of Thoracic Oncology (2017)
RARE-36. PATTERNS OF RELAPSE AFTER SUCCESSFUL COMPLETION OF INITIAL THERAPY IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA
Authors: Mallika P Weant, John Kirkpatrick, Margaret Johnson, Anastasie Dunn-Pirio, Patrick Healy, James E Herndon, Eric S Lipp, Eric Fountain, Annick Desjardins, Dina Randazzo, Henry S Friedman, Katherine B Peters
Journal: Neuro-Oncology (2017)

Primary central nervous system lymphoma (PCNSL) is a subtype of non-Hodgkin’s lymphoma that involves the brain, spinal cord or leptomeninges, without evidence of systemic disease. This rare disease accounts for ~3% of all primary central nervous system (CNS) tumors. Methotrexate-based regimens are the standard of care for this disease with overall survival rates ranging from 14 to 55 months. Relapse after apparent complete remission can occur. We sought to understand the outcomes of patients who relapsed. This is an IRB-approved investigation of patients treated at our institution between 12/31/2004 and 10/12/2016. All cases of PCNSL were retrospectively identified as part of a database registry and data were evaluated for demographic information, absence or presence of relapse, location of relapse, treatment regimens, and median time to relapse. Forty-four patients were identified with a diagnosis of PCNSL. Mean age at diagnosis was 63.1 yrs (range 20-86, SD=13.2 yrs). Of the 44 patients, 28 patients successfully completed an initial treatment regimen without recurrence or toxicity requiring a change in therapy. Relapse occurred in 11 patients with the location of relapse being in the CNS only (n=5), eye only (n=1), outside CNS only (n=3), or a combination of CNS and outside CNS (n=2). Sites of relapse outside of the CNS included testes (n=1), lung (n=1), adrenal gland (n=1), kidney/adrenal gland (n=1), and retroperitoneum (n=1). Median time to relapse from successful completion of therapy (95% CI) was 12.9 months (95% CI: 4.8-48.6 months). After successful initial treatment, PCNSL can relapse and this relapse can occur in the CNS and outside the CNS. Vigilant monitoring of off-treatment patients with a history of PCNSL is necessary to guide early diagnosis of relapse and to initiate aggressive treatment.
Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies
Authors: Kelly M. Hainline, Chelsea N. Fries, Joel H. Collier
Journal: Advanced Healthcare Materials (2017)

Supramolecular materials composed of proteins and peptides have been receiving considerable attention toward a range of diseases and conditions from vaccines to drug delivery. Owing to the relative newness of this class of materials, the bulk of work to date has been preclinical. However, examples of approved treatments particularly in vaccines, dentistry, and hemostasis demonstrate the translational potential of supramolecular polypeptides. Critical milestones in the clinical development of this class of materials and currently approved supramolecular polypeptide therapies are described in this study. Additional examples of not-yet-approved materials that are steadily advancing toward clinical use are also featured. Spherical assemblies such as virus-like particles, designed protein nanoparticles, and spherical peptide amphiphiles are highlighted, followed by fiber-forming systems such as fibrillizing peptides, fiber-forming peptide-amphiphiles, and filamentous bacteriophages.
MA 11.05 Targeted DNA- and RNA-Based Next-Generation Sequencing for Identifying MET Exon 14 Alterations in Pulmonary Sarcomatoid Carcinoma
Authors: L. Gao, Y. Li, B. Liu, L. Deng, L. Li, D. Ma, J. Li, G. Cheng, J. Ying, Z. Jiang
Journal: Journal of Thoracic Oncology (2017)
Gene Editing Provides Clues to Why Cancer Immunotherapy Often Fails
Authors: Tracy Hampton
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
La surveillance européenne de la légionellose associée aux voyages
Authors: C Joseph
Journal: Eurosurveillance (2004)

Lorsqu'une maladie est acquise dans un pays mais diagnostiquee et declaree dans un autre, une cooperation internationale est indispensable pour la controler, mener une investigation et eviter la survenue d'autres cas. Le programme europeen de surveillance de la legionellose associee aux voyages (EWGLINET) mis en place en 1987 pour repondre a ces situations a montre son efficacite dans le partage d'informations et la coordination des actions.
NIMG-86. THE STORY OF BITHALAMIC GLIOMAS: A SPECIAL EMPHASIS ON MASS INTERMEDIA
Authors: Bhanu Gogia, Prashant Rai, Vinodh Kumar, L Anne Hayman
Journal: Neuro-Oncology (2017)

To describe the pattern of spread of bithalamic tumors and possibly tailor the existing treatment modalities. Bilateral thalamic tumors are different from their counterparts presenting as unilateral thalamic gliomas. These are known to have poor prognosis, irrespective of their histopathology. There are two views regarding the origin. According to one view, bithalamic tumors arise on one side of thalamic nuclei and spread to the other side with time, while according to another view they arise by sprouting of tumors from the subependymal region of the third ventricle. We retrospectively studied the MR Imaging of 9 patients with gliomas involving thalamus bilaterally. We used FLAIR sequence in all 9 cases, in order to select a point of origin and locate massa intermedia. Additional data such as demographic details, the presence of obstructive hydrocephalus and tumoral enhancement patterns were also noted. The median age of the patients (3F, 6M) was 16 y/o. Six out of 9 patients had hydrocephalus, with massa intermedia noted in 6 cases whereas it was not appreciated in 3 cases due to the tumor size. Bilateral involvement of the thalamus was noted in 7 patients on their initial scan, 1 patient had tumor confined to the cavum velum interpositum, which caused the abnormal signal in the thalamus bilaterally and 1 patient had left sided unilateral glioma which later progressed to the right side. Bithalamic tumors share a poor prognosis. Massa intermedia seems to be a possible route of spread of tumor from one thalamus to the other and subependymal region of the third ventricle may be contributing. These views open a newer channel for prophylactic radiation covering MI and third ventricle to prevent the intact thalamus and hence improve the prognosis of the patients.
TMIC-51. EGFR AND EGFRvIII UPREGULATE MACROPHAGE INFILTRATION IN GLIOBLASTOMA THROUGH TLR2
Authors: Zhenyi An, William Weiss
Journal: Neuro-Oncology (2017)

Amplification of the EGFR gene is identified in over half of glioblastoma (GBM) patients, with about a third of EGFR-amplified tumors co-amplify EGFRvIII, a tumor-derived allele that is constitutively active. We previously reported that co-expression of EGFR and EGFRvIII promoted growth of glioblastoma tumors in vivo, identifying activated STAT3 as contributing to growth in a tumor-intrinsic manner. Those observations prompted us to analyze transcriptional profiles of glioblastoma cells to identify additional genes and pathways driven by EGFR and EGFRvIII. We found that in GBM cells co-expressing EGFR and EGFRvIII, a large group of cytokines were induced. Cytokines driven by EGFR and EGFRvIII induced macrophage infiltration in vitro and in intracranial tumors. The chemokine CCL2/MCP1 played a critical role in EGFR and EGFRvIII-induced macrophage infiltration. CRISPR/Cas9 mediated deletion of CCL2 in cells expressing EGFR and EGFRvIII decreased macrophage attraction in vitro and in intracranial tumors. Furthermore, EGFR and EGFRvIII signaled through TLR2 to drive CCL2 expression and macrophage recruitment. CRISPR/Cas9 mediated deletion of TLR2 in cells expressing EGFR and EGFRvIII decreased macrophage attraction and significantly prolonged survival of mice bearing intracranial tumors. In GBM patient samples, expression of TLR2 positively correlated with expression of CCL2. Patients with low levels of TLR2 in their tumors had improved survival compared to those with high expression of TLR2. This study provides new insights into the function of TLR2 in EGFR and EGFRvIII-amplified GBM, and provides novel therapeutic strategies for EGFR/EGFRvIII+ GBM patients.
NCOG-11. COGNITIVE FUNCTIONS AND VARIANTS IN GENES ASSOCIATED WITH AGING AND INFLAMMATION IN BRAIN TUMOR PATIENTS
Authors: Denise Correa, Jaya Satagopan, Maria Kryza-Lacombe, Siok Leong, Sofia Dimitriadoy, Kelli O’Connell, Lisa DeAngelis, Irene Orlow
Journal: Neuro-Oncology (2017)

Cognitive dysfunction is common in patients with brain tumors treated with radiotherapy (RT) and chemotherapy (CT). We reported previously that single nucleotide polymorphisms (SNPs) in the APOE, COMT and BDNF genes may influence cognitive outcome in this clinical population. In this study, we assessed whether additional genes with known associations with aging, Alzheimer’s disease and inflammation may contribute to cognitive dysfunction in brain tumor survivors. One hundred and fifty patients with brain tumors participated in the study: ninety had been treated with RT ± CT, fifty-seven had CT alone, and three had no therapy. All patients completed neuropsychological tests of attention, executive functions and memory, and provided a blood sample for genotyping. We used a Bayesian penalized multivariate regression approach to estimate the associations between the SNPs and cognitive outcome, adjusting for age, education, tumor location, treatment with RT ± CT, time since treatment completion, and APOE epsilon є-4 allele. We quantified the strength of association between a SNP and a cognitive test score using a novel measure referred to as the posterior association summary (PAS) that takes value between 0 (= no association) and 1 (= very strong association). Several SNPs previously reported in association with age-related cognitive decline and Alzheimer’s disease (PDE7A rs10808746, CD2AP rs9349407, ABCC1 rs8187858, APOE rs405697) and inflammation (IL-1A rs1800587, IL-1 rs1143634, IL-6 rs1474348) were strongly associated with tests of attention, executive functions and memory (PAS ≥ 0.95). Several additional SNPs that mapped to the ABCA7, CD33, COMT, IL-6, MS4A4E, PDE7A, PICALM, SERPINA3 and SORC1 genes were also associated with tests of attention and executive functions with PAS ≥ 0.90. The findings provide new evidence that polymorphisms in genes associated with aging, Alzheimer’s disease and inflammation may be functionally relevant and influence cognitive outcome in patients with brain tumors.