tbuckley/cabot-search huggingface dataset:
FRI0160 Evaluation of inflammatory cardiovascular (CV) risk factors in pre- and post-menopausal female patients with rheumatoid arthritis (RA)
Authors: OO Garmish, V Levchenko, V Kovalenko
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Objectives</h3> To assess inflammatory factors and peripheral vessels involvement as markers of cardiovascular risk in female patients with RA <h3>Methods</h3> 105 female patients who fulfill ACR/EULAR 2010 criteria were examined. Laboratory assessments consisted of biochemistry and hematology analysis, measuring of CRP level, rheumatoid factor, anti-CCP level, total cholesterol, HDL, LDL, thyroglobulin, apoliprotein, A1, apoliprotein B, uric acid, HbA1c, microalbuminuria. DAS28 was used in characterizing RA activity. CV risk was defined per mSCORE. Tibial artery and carotid artery ultrasonography examination included the measurement of cIMT in 3 points, detection of focal plaques in the extracranial carotid tree, blood flow velocity and morphology of the intima was performed <h3>Results</h3> 83.3% reproductive age patients were without CV risk, 11.1% experienced middle level and 5.6% low level of CV risk on mSCOR. In 96.1% postmenopausal patients moderate, high and very high CV risk was detected. According to multiple logistic regression analysis we identified CV risk factors: high CRP and DAS28, swollen joint count, LDL cholesterol level, menopause, thickness of cIMT and tibial artery. Were identify a significant correlation between tibial artery thickness and age, BMI, RA duration, systolic and diastolic blood pressure, cholesterol, menopause (p&lt;0.01, χ2=26.18). Also, we identified a significant relationship between tibial artery thickness and changes of the intima morphology (χ2=31,64; p&lt;0,01), carotid plaques (χ2=26,179; p&lt;0,01), sclerosis of the heart valves (χ2=25,78; p&lt;0,01). A less significant relationship was between cIMT (χ2=8,507; p&lt;0,01). The DAS28, age (p&lt;0.001), thickness of cIMT and tibial artery (p&lt;0.001) are predictive factors for the development of carotid plaques. The predictive factors for tibial artery thickness in female patients &lt;45 age are: high CRP (p&lt;0.004) and DAS28 (p&lt;0.03), anti-CCP positivity (p&lt;0.04), Vps internal carotid artery (p&lt;0.04) <h3>Conclusions</h3> The results of our study indicate that high CRP and DAS28 score, swollen joint count, LDL cholesterol level, menopause, thickness of cIMT and tibial artery associated with the increased cardiovascular risk. Tibial artery thickness and Vps internal carotid artery may be assessed like the new predictive factors of CV diseases in RA female patient <h3>Acknowledgements</h3> None <h3>Disclosure of Interest</h3> None declared
AB0339 Comorbidities and risk factors of cardiovascular diseases in rheumatoid arthritis patients
Authors: LV Khimion, None Klymas, IM Naishtetik
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> It is well known, that atherosclerosis associated cardiovascular diseases in many cases determine the life expectancy in RA patients. At the same time, risk factors which promote the development of premature atherosclerosis, including comorbidities, remain uncertain. <h3>Objectives</h3> to analyze comorbid conditions in RA patients under age of 50 years and assess their impact on the vascular wall (evaluated by ultrasound investigation of the carotid arteries). <h3>Methods</h3> The study was conducted at the Department of Family Medicine, Shupyk NMAPE at the Kyiv Regional Clinical Hospital. The study included 126 RA patients, aged from 18 to 49 years (women - 102 (81%), men - 24 (19%), average age 43.82±8.8 years, who provided written consent to participate in research. As a control group 30 persons without any autoimmune diseases (women - 25 (83.3%) men - 5 (16.7%), average age 42.4±8.6 years) were examined. All RA patients and control group underwent comprehensive clinical, laboratory and instrumental examination to identify comorbid conditions including evaluation of atherogenesis by use of ultrasound examination of the carotid arteries with intima-media thickness (IMT) measurement and atherosclerosis plagues (AP) assessment. <h3>Results</h3> The frequency of identified comorbid conditions and diseases in RA patients and control group are presented in Table 1. The average number of comorbid diseases/conditions per RA patient significantly exceeded its number in controls (4.13 and 1.67 respectively, p&lt;0.05); most frequently among RA patients was determined: dyslipidemia (60.32%), nonalcoholic fatty liver disease (61.11%), chronic cholecystitis (36.51%), cholesterosis of the gallbladder (30.16%), hypertension (37.30%), autoimmune thyroiditis (27.77%), spinal osteoarthritis (33.33%). Results of the carotid ultrasonography and assessment of atherosclerosis surrogate markers (IMT, AP) showed higher severity of atherosclerotic process in patients with RA compared to controls; the most important risk factors for increasing IMT and atherosclerotic plaques in carotid arteries were dyslipidemia, autoimmune thyroiditis with hypothyroidism and nonalcoholic fatty liver disease. <h3>Conclusions</h3> Patients with RA have a higher frequency of comorbid conditions and diseases than controls without RA; some of comorbidities have significant influence on atherogenesis; RA patients require a multidisciplinary and holistic approach for effective management of their health related problems. <h3>References</h3> Characteristics of comorbid stennov u hvorih on rheumatoid arthritis. Characteristics of comorbid conditions in patients with rheumatoid arthritis. Family Medicine 2015;3(59):219-222. <h3>Disclosure of Interest</h3> None declared
Occurrence, characterisation and antimicrobial resistance pattern of Staphylococcus aureus strains isolated from dairy products in southern Italy.
Authors: La . Salandra G, E. Goffredo, C. Pedarra, M.C. Nardella, A. Parisi, A. Dambrosio, N.C. Quaglia, G.V. Celano, G Normanno
Journal: Clinical Microbiology and Infection (2006)
臓器分布とクリアランスPEG化還元グラフェン酸化物及び生物学的結果の検出のためのRaman分光法【Powered by NICT】
Authors: Syama Santhakumar, Paul Willi, Sabareeswaran Arumugam, Mohanan Parayanthala Valappil
Journal: Biomaterials (2017)
In PCI-treated ACS, switching from aspirin + a newer P2Y12 blocker to aspirin + clopidogrel reduced adverse events
Authors: Angela Lowenstern, L. Kristin Newby
Journal: Annals of Internal Medicine (2017)

Source Citation Cuisset T, Deharo P, Quilici J, et al. Benefit of switching dual antiplatelet therapy after acute coronary syndrome: the TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study. Eur Heart J. 2017 May 16. [Epub ahead of print]. 28510646
SP0187 Associations of pain-related cognitions with the discordance between subjective and objective physical function in fibromyalgia: the al-Άndalus project
Authors: F Estévez-Lόpez
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> In fibromyalgia, there is a disagreement between patients9 self-reports and performances; i.e., subjective and objective status, respectively. <h3>Objectives</h3> First, to test the discordance between subjective and objective measures of physical function. Second, to determine whether catastrophizing and self-efficacy are independently associated with this discordance. <h3>Methods</h3> Four hundred and five fibromyalgia females and 193 age-matched female controls. Participants filled out the Pain Catastrophizing Scale, Chronic Pain Self-efficacy Scale, and physical functioning subscales of the Revised Fibromyalgia Impact Questionnaire (FIQR) and Short Form-36 (SF-36) health survey. Objective physical function was measured with a battery of performance-based tests (e.g., 6-min walk test). Subjective and objective physical function were expressed as deviation from the general population in standard deviation (<i>SD</i>) units using means and <i>SD</i> of the control group. <h3>Results</h3> Fibromyalgia participants reported a worse physical function than performed (<i>p</i>&lt;.001). We found a consistent association of higher catastrophizing with greater discordance between subjective and objective physical function. A significant association of higher self-efficacy with lower discordance was only found when subjective physical function was reported on the SF-36 but not on the FIQR. <h3>Conclusions</h3> Although both are markedly impaired, subjective physical function is more impaired than objective physical function in fibromyalgia. Catastrophizing is associated with this discordance. In rehabilitation settings, physical function of fibromyalgia females should be evaluated by both subjective and objective assessments to fully understand their physical function. <h3>Acknowledgements</h3> This work was supported by the Spanish Ministry of Economy and Competitiveness [I+D+i DEP2010–15639, I+D+i DEP2013–40908-R, and BES-2014–067612]. <h3>Disclosure of Interest</h3> None declared
AB0462 Vitamin d supplementation significantly reduces cholesterol in sle
Authors: M Petri, LS Magder
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> The benefit of vitamin D on SLE global and renal activity have now been proven by both cohort studies and a clinical trial. The benefits on cardiovascular risk factors, however, are less well understood. <h3>Objectives</h3> We present the first longitudinal study on hyperlipidemia. <h3>Methods</h3> A within-person aanalysis addressed the question of whether a person tends to have higher cholesterol when her vitamin D is lower than her average vitamin D. To assess this, for each visit, we calculated the difference between the vitamin D level at that visit and the person9s average of vitamin D. Differences in the range of vitamin D &lt;50 ng/mL were distinguished from differences in the range above 50 ng/mL. Then we modelled the relationship between these differences in vitamin D and the difference between the person9s cholesterol at each visit and the person9s average cholesterol. <h3>Results</h3> This means that at a particular clinic visit, if a person9s vitamin D is higher than the person9s mean vitamin D by 10 ng/mL and the person has vitamin D below 40 ng/mL, then the expected cholesterol will decrease by 3.4 mg/dL. There is no significant effect of higher vitamin D among those whose mean vitamin D exceeds 50. <h3>Conclusions</h3> Vitamin D supplementation (in those whose level is below 40 ng/mL) has a significant benefit on total cholesterol that is independent of age, sex, ethnicity, Plaquenil, prednisone and body mass index. Vitamin D supplementation - as it also helps systolic blood pressure - is both important for SLE activity and for reduction of cardiovascular disease. <h3>Disclosure of Interest</h3> None declared
Endoscopic ultrasound-guided choledochoduodenostomy with novel use of contrast-enhanced harmonic imaging
Authors: Kosuke Minaga, Mamoru Takenaka, Ken Kamata, Takeshi Miyata, Kentaro Yamao, Hajime Imai, Masatoshi Kudo
Journal: Endoscopy (2017)

Since it was first described in 2001 [1], endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) has been increasingly used as an alternative for biliary decompression after failed endoscopic retrograde cholangiopancreatography (ERCP). EUS-CDS has an overall technical success rate of more than 90 % [2] [3], but puncturing the common bile duct (CBD) can be challenging in patients with hemobilia because it presents as a heterogeneous echogenicity. Here, we present a patient for whom EUS-CDS was successfully performed under contrast-enhanced harmonic EUS (CH-EUS) guidance.
Sex, drugs and rock ‘n roll
Authors: Johannes Zwerver, Suzan de Jonge
Journal: British Journal of Sports Medicine (2017)

The Dutch are very proud to be known as open-minded people. We don’t feel uncomfortable talking about ribald things as sex, drugs and rock ‘n roll. However, the Netherlands are much more than just that.

During the Dutch Golden Age, trade, science and art from Holland were among the most acclaimed in the world. The VOC (Verenigde Oostindische Compagnie/United East Indies Company) was an innovative company with international trade in many countries all over the world. Merchants explored the world and were searching for bright spots for successful trading.

Nowadays, the VSG (Vereniging voor Sportgeneeskunde/Dutch Sports Medicine Association) is pre-eminent in the field of Sport & Exercise Medicine. Due to the enormous efforts of the VSG, sport and exercise medicine has now been recognised as a medical specialty in the Netherlands and well-trained sport and exercise physicians practise in a growing number of Dutch and overseas hospitals.

In this VSG edition, we take you on a …
THU0225 Role of the IL-12/IL-35 balance in SJÖGREN'S syndrome
Authors: O Fogel, E Rivière, R Seror, G Nocturne, S Boudaoud, B Ly, J-E Gottenberg, V Le Guern, J-J Dubost, J Nititham, K Taylor, P Chanson, P Dieudé, L Criswell, C Miceli, X Mariette
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> An interferon (IFN) signature is involved in the pathogenesis of primary Sjögren9s syndrome (pSS), but whether the signature is type 1 or 2 remains controversial. Mouse models and genetic studies suggested the involvement of T helper 1 and type 2 IFN pathways. Likewise, polymorphisms of interleukin 12A gene (<i>IL-12A</i>), which encodes for IL-12p35, have been associated with pSS. IL-12p35 subunit is shared by 2 heterodimers, IL-12 and IL-35. <h3>Objectives</h3> To confirm the genetic association of <i>IL-12A</i> polymorphism and pSS and elucidate the involvement of the IL-12/IL-35 balance in pSS by functional studies. <h3>Methods</h3> The genetic study involved 673 patients with pSS from 2 French pSS cohorts and 585 healthy French controls. Functional studies were performed on sorted monocytes, stimulated or not. IL-12A mRNA and IL-12 and IL-35 protein levels were assessed by qRT-PCR and by ELISA and a multiplex kit for IL-35 and IL-12, respectively. <h3>Results</h3> We confirmed the association of the <i>IL-12A</i> rs485497 polymorphism and pSS and found an increased serum protein level of IL-12p70 in pSS patients carrying the risk allele (p=0.016). Serum level of IL-12p70 was greater in patients than controls (p=0.0001), especially patients with more active disease (p=0.05); conversely IL-35 level was decreased in patients (p=0.0001) especially in patients with a more active disease (p=0.05). <h3>Conclusions</h3> Our findings emphasize the involvement of the IL-12/IL-35 balance in the pathogenesis of pSS. Serum IL-35 level was associated with low disease activity, in contrast to serum IL-12p70 level, which was rather associated with a more active disease. <h3>Acknowledgements</h3> We thank Dr Odile Devergne (Université Paris Descartes, AP-HP, Hôpital Necker, Paris) for her expertise on the IL-35 ELISA kit to ensure the quality and reproducibility of this test. The authors thank the following investigators of the ASSESS cohort prospective cohort of patients with Sjögren9s syndrome (all in France) who recruited the patients and conducted follow-up: A. L. Fauchais (Limoges), S. Rist (Orleans), V. Le Guern (Paris), G. Hayem (Paris), J. Sibilia (Strasbourg), J. Morel (Montpellier), A. Saraux (Brest), A. Perdriger (Rennes), X. Puechal (Le Mans), E Hachulla (Lille) and V. Goeb (Rouen). The authors thank Dr J. Benessiano, S Tubiana and all staff members of the Bichat Hospital Biological Resource Center (Paris) for their help in centralizing and managing biologic data collection from the French ASSESS, <h3>Disclosure of Interest</h3> None declared
OP0013 Pulmonary manifestations in juvenile onset mixed connective tissue disease after long-term disease duration – a norwegian case-control study
Authors: SO Hetlevik, TM Aaløkken, MB Lund, B Flatø, EB Nordal, M Rygg, V Lilleby
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Pulmonary manifestations in mixed connective tissue disease (MCTD) are common and a major cause of morbidity and mortality [1]. Data on lung involvement in patients with juvenile onset MCTD (JMCTD) are scarce. <h3>Objectives</h3> The aim of this study was 1) to compare pulmonary function abnormalities in a nationwide representative Norwegian JMCTD cohort with that of matched controls, 2) investigate occurrence of interstitial lung disease (ILD) in JMCTD and 3) to evaluate possible associations between pulmonary findings and disease related variables. <h3>Methods</h3> Inclusion criteria were fulfillment of the Kasukawa or Alarcon-Segovia criteria and symptom-onset before 18 years. The control group was randomly drawn from the national population register, after matching for age and gender. Fifty-two patients with JMCTD were examined after mean disease duration 16.2 years, 44 (85%) were female. Patients and controls performed pulmonary function tests (PFT) and a 6 min walk test (6MWT). The patients had a high-resolution CT (HRCT) of the lungs. <h3>Results</h3> Abnormal PFT were found in 24 patients (46%) and in 12 controls (23%) (p=0.01) (table 1). More patients than controls had abnormal FVC (11 patients and 0 controls, p&lt;0.01) and FEV1 (12 patients and 2 controls, p&lt;0.01). Diffusing capacity for carbon monoxide adjusted for alveolar volume was abnormal in 12 patients and 8 controls (p=0.34). One patient and 3 controls had a pathological FEV1/FVC (less than 70% of predicted, p 0.62). HRCT showed ILD in 15 patients (29%). The extent of lung parenchyma involved was median 2% (range 1–75) in the patients with ILD. Two patients had more than 20% of lung parenchyma involved (graph 1). The most common abnormalities were reticular patterns, being present in 13 patients (25%). 2 patients (4%) had ground glass attenuation.We could not find correlations between the extent of ILD and PFT or 6MWT. There were no significant differences in PFT values or other disease related variables between the patients with and without ILD. <h3>Conclusions</h3> Patients with JMCTD had significantly reduced pulmonary function after mean 16.2 years disease duration compared to matched controls. However, overall lung function was only moderately reduced. The occurrence of ILD assessed with HRCT was 29%, but the majority of patients with ILD had mild disease. To our knowledge, this is the first systematic case-control study of pulmonary manifestations in JMCTD. <h3>References</h3> Gunnarsson R, Aalokken TM, Molberg O, et al. Prevalence and severity of interstitial lung disease in mixed connective tissue disease: a nationwide, cross-sectional study. Ann Rheum Dis 2012;71:1966–72. <h3>Disclosure of Interest</h3> None declared
Oral all-trans retinoic acid plus danazol versus danazol as second-line treatment in adults with primary immune thrombocytopenia: a multicentre, randomised, open-label, phase 2 trial
Authors: Fei-Er Feng, Ru Feng, Min Wang, Jia-Min Zhang, Hao Jiang, Qian Jiang, Jin Lu, Hui Liu, Jun Peng, Ming Hou, Jian-Liang Shen, Jing-Wen Wang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, Xiao-Hui Zhang
Journal: The Lancet Haematology (2017)
SP0076 How and when to assess the cervical facet joints + demo
Authors: DA Bong
Journal: Annals of the Rheumatic Diseases (2017)

At any given time, 10% of the adult population will be affected by neck pain. Although similar in incidence to low back pain, its has less of a socio-economic impact and uncommonly progresses to neurologic deficit. Pain may result from degenerative, traumatic or inflammatory processes involving the diarthrodial facet (zygapophyseal) joints and/or the facet (medial branch of the dorsal dorsal rami) nerves. Although routinely evaluated by radiography, magnetic resonance imaging and computed tomography, high-resolution musculoskeletal ultrasound (MSKUS) imaging and guidance has become increasingly popular, particularly among pain management specialists, in the evaluation and treatment of these structures owing to its safety, portability, superior resolution and direct real-time visualization. This presentation will discuss the unique anatomy and sonoanatomy of the cervical spine and its innervation/vascularization with particular focus on the facet joints and nerves and the use of MSKUS in the evaluation and treatment of the facet joint/nerve with review of available evidence. Examination technique and sonoanatomic findings will be demonstrated. <h3>Disclosure of Interest</h3> None declared
Prevalence and timing of TP53 mutations in del(17p) myeloma and effect on survival
Authors: M Chin, J I Sive, C Allen, C Roddie, S J Chavda, D Smith, P Blombery, K Jones, G L Ryland, R Popat, A Rismani, S D'Sa, N Rabin, R E Gale, K L Yong
Journal: Blood Cancer Journal (2017)

The recent remarkable advances in multiple myeloma (MM) therapy and outcomes have had mixed impact on patients with adverse risk genetics, many of whom continue to have inferior outcomes. This applies particularly to deletion of chromosome 17p13 [del(17p)], found in ≈10% of newly diagnosed MM (ND) and at higher prevalence in advanced disease.1, 2, 3, 4, 5 The TP53 gene is located within the minimally deleted region on 17p13, and is thought to confer the adverse risk in a haploinsufficient manner.6 The incidence of TP53 mutations in ND is ≈3% but also increases with disease progression,7, 8 and is associated with shorter survival.9 Although TP53 mutations are uncommon in the absence of del(17p), approximately one third of del(17p) MM patients are reported to have a TP53 mutation, and this increases in refractory disease to more than 50%.8, 10