tbuckley/cabot-search huggingface dataset:
L'épidémie de poliomyélite en Albanie, 1996
Authors: M L Ciofi Degli Atti, R Prevots, A Sallabanda, P Malfait, E Diamantil, B Aylward, D Greco, S Wassilak
Journal: Eurosurveillance (1997)

Entre avril et novembre 1996, une grande epidemie de polio est survenue en Albanie, pays qui etait exempt de polio depuis 1985. Bien que l'Albanie n'eut pas declare de cas de polio pendant cette periode, le risque d'introduction et de circulation d'un poliovirus sauvage avait augmente. Ce risque provenait de problemes qui etaient survenus dans la maintenance de la chaine du froid pour les stocks de vaccins, d'une diminution de la couverture de la vaccination par le vaccin attenue oral (VPO) au debut des annees 90 a l'epoque de la transition politique, et de l'ouverture des frontieres entrainant une migration massive depuis 1992, et donc des contacts plus faciles avec des populations venant de pays ou la polio est endemique. Afin de controler ce risque, des Journees Nationales de Vaccination contre la polio (JNV) ont ete organisees dans toute l'Albanie en avril et mai 1996, ciblees sur les jeunes enfants jusqu'a l'âge de cinq ans ; une couverture de 98% a ainsi ete atteinte.
New Tool to Aid Zika Diagnostics
Authors: Rebecca Voelker
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GW28-e1030 Endothelial and Platelet microparticles in cardiac syndrome X
Authors: Yousef Rasmi, Fereshteh Ghaffari, None ShahramSeyedi, MirHossein SeyedMohammadzad, Alireza Rostamzadeh, Elmira Roshani
Journal: Journal of the American College of Cardiology (2017)
Molecular Biomarker to Assist in Diagnosing Abdominal Sepsis upon ICU Admission
Authors: Brendon P. Scicluna, Maryse A. Wiewel, Lonneke A. van Vught, Arie J. Hoogendijk, Augustijn M. Klarenbeek, Marek Franitza, Mohammad R. Toliat, Peter Nürnberg, Janneke Horn, Marc J. Bonten, Marcus J. Schultz, Olaf L. Cremer, Tom van der Poll
Journal: American Journal of Respiratory and Critical Care Medicine (2017)
Reaparición de la difteria en Europa
Authors: M Rey, O Patey, F Vincent-Ballereau
Journal: Eurosurveillance (1996)

Dado que los ninos son vacunados sistematicamente, la difteria ha sido eliminada en la mayoria de los estados europeos y el reciente resurgimiento de una gran epidemia en los Nuevos Estados Independientes (NEI) de la antigua URSS constituye algo inesperado. El resurgimiento de la difteria en los NEI suscita las siguientes preguntas: ?Se propagara la epidemia? ?De que manera puede controlarse? ?Constituye una amenaza para los demas paises europeos? ?Estan los paises europeos lo suficientemente protegidos contra una reaparicion de la difteria?
Abstract P356: Association Between Sleep Disturbances and Dyslipidaemia: Systematic Review and Meta-analysis of Prospective Studies
Authors: Marlot Kruisbrink, Wendy Robertson, Chen Ji, Michelle A Miller, J M Geleijnse, Francesco P Cappuccio
Journal: Circulation (2017)

Objectives: To assess the longitudinal evidence of the relationship between sleep disturbances (of quantity and quality) and dyslipidaemia in the general population and to quantify such relationships. Methods: We performed a systematic search of PubMed and EMBASE (up to July 2016), complemented with manual searches. Studies were included if they were prospective, had sleep quantity and/or quality at baseline and either incident cases of dyslipidaemia or changes in any of the lipid fractions assessed prospectively. Relative risks (95% CIs) were extracted and pooled using a random effect model. Sub-group analyses by lipid type and cumulative meta-analysis by publication date were also performed. Heterogeneity and publication bias were assessed. Results: 13 studies were identified (4 on quality, 11 on duration). There was heterogeneity in the sleep quality aspects and types of lipids assessed. Classification of sleep duration (per hour/groups) and outcome reporting (changes, risks, differences) also varied widely. In the pooled analysis of sleep duration (6 studies, 16 cohort samples; 30,021 participants; follow-up 2.6-10 years), short sleep was associated with a risk of 1.01 (95% CI: 0.93-1.10) of developing dyslipidaemia, with moderate heterogeneity (I 2 =56%, p=0.003) andpublication bias (p=0.035). Long sleep was associated with a risk of 0.98 (95% CI: 0.87-1.10) for dyslipidaemia, with heterogeneity (I 2 =63%, p&lt;0.001) and no publication bias (p=0.248). However, subgroup analyses suggested a trend for higher TChol in short sleepers (1.10; 0.99-1.22; p=0.07) and lower TChol in long sleepers (0.91; 0.81-1.01; p=0.087). Cumulative meta-analysis shows a general trend towards no effect for both short and long sleep duration with dyslipidaemia. Conclusion: The results do not support a significant relationship between sleep duration and the development of dyslipidaemia. However, heterogeneity in the reporting of both exposure and outcomes and some publication bias limit the interpretation.
The immature electrophysiological phenotype of iPSC-CMs still hampers in vitro drug screening: Special focus on I K1
Authors: Birgit Goversen, Marcel A.G. van der Heyden, Toon A.B. van Veen, Teun P. de Boer
Journal: Pharmacology & Therapeutics (2017)

Preclinical drug screens are not based on human physiology, possibly complicating predictions on cardiotoxicity. Drug screening can be humanised with in vitro assays using human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, in contrast to adult ventricular cardiomyocytes, iPSC-CMs beat spontaneously due to presence of the pacemaking current If and reduced densities of the hyperpolarising current IK1. In adult cardiomyocytes, IK1 finalises repolarisation by stabilising the resting membrane potential while also maintaining excitability. The reduced IK1 density contributes to proarrhythmic traits in iPSC-CMs, which leads to an electrophysiological phenotype that might bias drug responses. The proarrhythmic traits can be suppressed by increasing IK1 in a balanced manner. We systematically evaluated all studies that report strategies to mature iPSC-CMs and found that only few studies report IK1 current densities. Furthermore, these studies did not succeed in establishing sufficient IK1 levels as they either added too little or too much IK1. We conclude that reduced densities of IK1 remain a major flaw in iPSC-CMs, which hampers their use for in vitro drug screening.
An insight into the complex roles of metallothioneins in malignant diseases with emphasis on (sub)isoforms/isoforms and epigenetics phenomena
Authors: Sona Krizkova, Marta Kepinska, Gabriella Emri, Tomas Eckschlager, Marie Stiborova, Petra Pokorna, Zbynek Heger, Vojtech Adam
Journal: Pharmacology & Therapeutics (2017)
OReO/ENGOT Ov-38: A phase IIIb trial of olaparib maintenance retreatment in patients with epithelial ovarian cancer
Authors: E. Pujade-Lauraine, N. Colombo, R. Glasspool, B. Asselain, T. Huzarski, J. Korach, F. Marme, M.R. Mirza, A. Redondo, G. Scambia, C. Blakeley, A. Milner, F. Selle, I. Vergote
Journal: Annals of Oncology (2017)
Absence d’infection chez les contacts asymptomatiques du cas index de SRAS en France
Authors: S Le Vu, Y Yazdanpanah, D Bitar, J Emmanuelli, I Bonmarin, J C Desenclos
Journal: Eurosurveillance (2006)

Le premier cas francais de syndrome respiratoire aigu severe (SRAS) a ete diagnostique en mars 2003. Nous avons mis en place une etude sero-epidemiologique afin de savoir si les personnes asymptomatiques en contact avec ce patient durant sa periode contagieuse avaient ete infectees. Un questionnaire et un echantillon de sang pour tester la presence d’anticorps diriges contre le coronavirus responsable du SRAS ont ete recueillis aupres de 37 personnes eligibles. Aucun serum n’a ete retrouve positif vis-a-vis du virus du SRAS chez ces personnes contacts asymtomatiques. Ce resultat confirme la pertinence d’une definition de cas du SRAS basee sur des criteres cliniques et epidemiologiques.
A retrospective study of endocrine therapy in high grade serous ovarian carcinoma
Authors: B. Stanley, R.L. Hollis, J.D. Towler, X. Yan, H.D.S.M. Nunes, T. Rye, S. Herrington, M. Churchman, M. MacKean, F. Nussey, C. Gourley
Journal: Annals of Oncology (2017)
Intracerebral microdialysis for determination of the neuropharmacokinetics and neuropharmacodynamics of temozolomide in patients with primary or metastatic brain tumors
Authors: J. Portnow, B. Badie, B. Xi, A. Liu, D. Hovda, D. Hirt, T. W. Synold
Journal: Journal of Clinical Oncology (2007)

2074 Background: Microdialysis (MD) is a technique for continuously analyzing concentrations of endogenous chemicals and drugs in the extracellular fluid (ECF) of a body tissue. The purpose of this study is to apply MD to the determination of the neuropharmacokinetics (nPK) and neuropharmacodynamics (nPD) of temozolomide (TMZ) following systemic administration. Methods: After surgical debulking, a MD catheter is placed in peritumoral brain tissue. Artificial cerebrospinal fluid (CSF) is continuously perfused at a rate of 1 μl/min. Fused CT/MRI scans confirm correct placement of the catheter in non-enhancing brain. Starting 24 hrs after surgery, patients are given a dose of TMZ (150 mg/m 2 ), and serial ECF and plasma samples are collected over 24 hrs. TMZ concentrations are determined by LC/MS/MS. In vitro recovery of TMZ via the MD catheter has been determined to be 87±5.5% at a flow rate of 1 μl/min. Prior to and 24 hrs post TMZ, additional ECF samples are collected for analysis of glucose, glutamate, lactate, and pyruvate, which are measured using a CMA 600 Analyzer®. Results: Four patients have been enrolled. There have been no grade 3 or 4 catheter-related adverse events. Mean peak TMZ concentrations in brain ECF and plasma are 0.4±0.2 and 5.5±1.4 μg/ml, respectively. Mean TMZ AUC in brain ECF and plasma are 3.2±1.6 and 18.2±4.6 μg/mLxhr, with an average ECF/plasma AUC ratio of 18±4%. Mean basal levels of glucose, glutamate, lactate, and pyruvate in ECF are 0.4±0.3, 34±66, 3±4, 69±62 mM, respectively. No consistent changes were seen in these nPD markers 24 hrs after TMZ. Conclusions: Concentrations of TMZ in brain ECF obtained by MD are similar to published data of TMZ concentrations in the CSF (Clin Cancer Res 2004;10:3728–36). Baseline values of markers of brain tissue metabolism are consistent with previous data in patients with brain tumors (J Neuro-Oncol 2003; 61:151–60). Intracerebral MD is an important tool that can be applied to nPK/nPD studies of new and targeted agents for the treatment of brain tumors. (Supported by CA01727) No significant financial relationships to disclose.
Phase II randomized trial of capecitabine + radiation therapy with/without bevacizumab as preoperative treatment for patients with resectable locally advanced rectal adenocarcinoma: Final results of 3 and 5-year disease free survival, distant relapse free survival and overall survival
Authors: C. Gravalos, J. Capdevila, L. Layos, C. Pericay, M. Martínez-Villacampa, C. López López, F. Losa, M.J. Safont, A. Gómez-España, V. Alonso, P. Escudero, J. Gallego, B. García-Paredes, A. Palacios, S. Biondo, R. Salazar, E. Aranda Aguilar
Journal: Annals of Oncology (2017)
Efficacy of anamorelin in advanced non-small cell lung cancer (NSCLC) patients with anorexia/cachexia and modified Glasgow Prognostic Score (mGPS) of 2: Pooled analysis of two phase 3 trials
Authors: S. Kaasa, B. Laird, M. Fallon, D. McMillan, R. Skipworth, D. Currow, R. Giorgino
Journal: Annals of Oncology (2017)
Actionable molecular alterations in advanced biliary tract carcinomas: Preliminary data from the ProfiLER program (NCT01774409)
Authors: P. Cassier, C. de la Fouchardiere, P. Guibert, D. Pissaloux, C. Pacaux, C. Terret, L. Eberst, M. Sarabi, V. Attignon, Q. Wang, V. Corset, D. Perol, J-Y. Blay, F. Desseigne
Journal: Annals of Oncology (2017)
HELICS: un proyecto europeo para la estandarización de la vigilancia de infecciones adquiridas en hospitales, 1994-1995
Authors: R Mertens, J. M.J van den Berg, J Fabry, O. B Jepsen
Journal: Eurosurveillance (1996)

En la decada de los '90 varios paises europeos empezaron a crear redes nacionales o regionales para la vigilancia de infecciones adquiridas en hospitales. La mayoria de estas redes se basaban en el modelo ofrecido por el 'National Nosocomial Infection Surveillance System' (NNIS, o Sistema Nacional de Vigilancia de Infecciones Nosocomiales) de los 'US Centers for Disease Control and Prevention' (CDC, o Centros para el Control y la Prevencion de Enfermedades de EE.UU.), el proyecto EURONIS patrocinado por la UE (Infecciones Nosocomiales en Unidades de Cuidados Intensivos de Europa) o la iniciativa DANOP/WHOCARE, coordinada por la Oficina Regional de la OMS de Europa y el 'Statens Seruminstitut' de Copenhague.
Abstract 1213: Arginase Inhibition Decreases Vascular Stiffness and Increases NO production In Apo E Knock-out Mice
Authors: Alexandre M Benjo, Gaurav Gupta, Sungwoo Ryu, Hyun K Lim, Lakshmi Santhanam, Kevin Ssoucy, Jayson Sohi, Laxmi Pellakuru, Mirinda Anderson, Artin A Shoukas, Gary Gersternblith, Daniel Nyhan, Dan E Berkowitz
Journal: Circulation (2006)

Background: We have previously demonstrated that OxLDL increases arginase (Arg) activity and decreases endothelial NO in human aortic endothelial cells Hypothesis: Vascular Arg activity is increase...
Reply to Letter: Outbreaks caused by parvovirus B19
Authors: G Gonçalves, A M Correia, P Palminha, Helena Rebelo-Andrade, A Alves
Journal: Eurosurveillance (2005)

We are grateful for the comments provided by Kelly and Leydon, and Bernard J Cohen. They seem to share our previously expressed opinion that ’in the context of measles and rubella elimination programs, study protocols should include data collection procedures and laboratory tests able to confirm or discard the diagnosis of B19 infections.’ [1]. They have provided a useful commentary with relevant information and references.
Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion
Authors: Marcus A. Carden, Meredith E. Fay, Xinran Lu, Robert G. Mannino, Yumiko Sakurai, Jordan C. Ciciliano, Caroline E. Hansen, Satheesh Chonat, Clinton H. Joiner, David K. Wood, Wilbur A. Lam
Journal: Blood (2017)
Novas tendências de hepatite viral aguda, encontradas por clínicos gerais Belgas
Authors: D Devroey, V van Casteren, R Vranckx
Journal: Eurosurveillance (1997)

Na Belgica, a rede de medicos-sentinela constituida por clinicos gerais foi estabelecida em 1979 e monitoriza uma ampla gama de doencas infecciosas e nao-infecciosas (1,2). Estes sistemas de vigilâncias tem sido testados e tem provado ser eficazes (3,4) e sao, presentemente, aplicados em varios paises (5). A rede de medicos-sentinela estudou primeiro a incidencia de hepatite viral aguda sintomatica entre 1982 e 1984 (6,7). Os casos clinicos foram investigados pelo Centro Nacional para a Hepatite Viral, o qual analisou amostras de sangue de doentes clinicamente suspeitos de ter hepatite viral aguda (8). Os resultados laboratoriais foram extrapolados para a populacao Belga, a fim de estimar a incidencia dos tipos diferentes de hepatite viral aguda (9).
Redes internacionais de vigilância e princípios de colaboração
Authors: I. S.T. Fisher, O N Gill
Journal: Eurosurveillance (2001)

Com a multiplicacao e o desenvolvimento das redes internacionais de vigilância das doencas transmissiveis, surgem varias questoes sobre a transmissao de dados e informacoes pessoais. A natureza confidencial dos dados partilhados e a divulgacao dos dados a nivel internacional, dentro e fora da rede, constituem fontes potenciais de conflitos. Para resolver estes problemas, a Enter-net desenvolveu os 'Principios de Colaboracao' que se destinam a ser aplicados a todos os participantes da rede e a outros participantes que possam estar envolvidos. Estes principios propoem solucoes para as questoes relacionadas com o acesso as bases de dados criadas dentro da estrutura da rede, a qualidade e confidencialidade dos dados em circulacao, a responsabilidade individual na identificacao de um produto incriminado em caso de surto e, mesmo, a transmissao de informacoes para fora da rede. O objectivo principal destes principios, que sao revistos regularmente, e o de optimizar a deteccao precoce e gestao de surtos transmitidos pelos alimentos e a execucao das medidas necessarias para a saude publica. No entanto, considerando a natureza dos problemas, alguns destes principios sao igualmente relevantes para outras redes de vigilância.
Abstract P045: Public Attitudes to Government Intervention to Improve Children’s Diets
Authors: Narelle M Berry, Patricia Carter, Rebecca Nolan, Eleonora Dal Grande, Sue Booth
Journal: Circulation (2016)

Introduction: Globally the prevalence of overweight and obesity in children is increasing. For effective population level dietary intervention comprehensive packages, including policy action across food environments, food supply chains and behaviour change communication are required to ensure that it is easy for both adults and children to make healthy food choices. The World Health Organization has called on governments to implement recommendations on the marketing of foods and beverages to children. Public support of government intervention is likely to influence government action in this area: thus this study aimed to explore public attitudes to government intervention in the area of unhealthy food marketing to children and related matters. Methods: Data for this study were collected using a computer-assisted telephone interview. Households were randomly selected and the person aged ≥18 years with the most recent birthday was selected for interview. Respondents were asked to report their agreement on a five point Likert scale ranging from strongly agree to strongly disagree on questions relating to the role of government in: regulating food advertising to children, educating parents on healthy eating, and in requiring manufacturers to make food healthier, and their opinion on current food advertising practices. Data are presented as the proportion of respondents who agreed/strongly agreed with each statement. Results: A total of 3911 adults responded to this survey (2008: n=1910, 2011: n=2001) and overall there was high agreement with most survey statements: 87.0% of respondents strongly agreed/agreed that governments should regulate the way food or drink is marketed to children; 92.9% strongly agreed/agreed that governments should help educate families on healthy eating; 85.7% strongly agreed/agreed that governments should require manufacturers to make children’s food healthier; and 75.9% strongly agreed/agreed that there is too much advertising of unhealthy food during children’s television viewing time. When asked how governments should intervene, 60.8% of respondents strongly agreed/agreed on a total ban on advertising unhealthy foods and 86.4% strongly agreed/agreed on a ban on advertising of unhealthy food at times when children watch television. Conclusions: The results of this study demonstrate that there is high public support for governments to intervene to decrease unhealthy food marketing to children. Despite this, governments have been reluctant to act and more effort is needed to harness public opinion to influence and inform policy development.
Preventing congenital rubella infection in the European Region of WHO: 2010 target
Authors: J. S. Spika, F X Hanon, S Wassilak, R G Pebody, N Emiroglu
Journal: Eurosurveillance (2004)

The World Health Organisation (WHO) Regional Office for Europe has recently published a strategic plan and surveillance guidelines for measles and congenital rubella infection. The strategy prioritises measles control activities but encourages the introduction of rubella vaccine when measles vaccine coverage has reached &amp;gt;90 %; although, many western European countries with suboptimal measles vaccine coverage are already using the combined measles, mumps and rubella (MMR) vaccine. Women in these countries may have an especially high risk of having an infant with congenital rubella syndrome. WHO is seeking to improve the surveillance for rubella and congenital rubella syndrome as a means to obtain better information on the burden of these diseases and engage policy decision makers in the need to support the WHO European Region's strategies for rubella.
An outbreak of Adenovirus type 8 Keratoconjunctivitis in a nursing home in Madrid
Authors: J M Sendra Gutierrez, D Martin Rios, I Casas, P Sáez, A Tovar, C Moreno
Journal: Eurosurveillance (2004)

This work describes and analyses an outbreak of epidemic keratoconjunctivitis which occurred in 2001 and 2002 in a nursing home for the elderly in Leganes (an area of Madrid). This is the first such published case in Spain with these characteristics and this serotype identification. Sociodemographic characteristics, epidemic curve and attack rates are described. Comparisons of the data were carried out using a chi2 test for qualitative variable and t-test for quantitative. Factors associated with the illness are explored by means of contingency tables and logistic regression models. One hundred and two cases were detected, with an attack rate of 36.4% for residents, and 12.9% for workers, not considering spatial or professional differences. The epidemic curve showed an interpersonal transmission pattern. Multivariate analysis identified the following risk factors in the residents: able to wander freely through the building, urinary incontinence and use of shared bathroom. In 34.6% of the conjunctival samples, adenovirus serotype 8 was detected with identical genomic sequence. Establishment of hygienic sanitary guidance adapted for the cleaning of such establishments and contact with residents as well as early diagnosis and good coordination of human and material resources are key factors in the prevention and control of these outbreaks in closed communities.
Detection of esophageal cancer patients using circulating serum microRNA from the result of comprehensive analysis
Authors: K. Kato, K. Sudo, N. Boku, S. Abe, Y. Saito, K. Koyanagi, H. Daiko, J. Kawauchi, S. Takizawa, H. Sakamoto, S. Niida, F. Takeshita, J. Matsuzaki, T. Ochiya
Journal: Annals of Oncology (2017)
Osimertinib vs standard of care (SoC) EGFR-TKI as first-line therapy in patients (pts) with EGFRm advanced NSCLC: FLAURA
Authors: S. Ramalingam, T. Reungwetwattana, B. Chewaskulyong, A. Dechaphunkul, K.H. Lee, F. Imamura, N. Nogami, Y. Ohe, Y. Cheng, B.C. Cho, E.K. Cho, J.F. Vansteenkiste, P.J. Voon, C. Zhou, J. Gray, R. Hodge, Y. Rukazenkov, J-C. Soria
Journal: Annals of Oncology (2017)
Should pancreatic cancer be included in BRCA1/2 testing criteria?
Authors: M. Venturelli, A. Toss, S. Pipitone, I. Marchi, E. Tenedini, V. Medici, E. Tagliafico, E. Razzaboni, F. Spaggiari, E. De Matteis, S. Cascinu, L. Cortesi
Journal: Annals of Oncology (2017)