Abstract A19: Dietary-fiber and fecal fiber contents including pH in rural Africans with colorectal cancer
Authors: Mohammed Faruk, Sani Ibrahim, Ahmed Adamu, Abdulmumini Hassan Rafindadi, Yahaya Ukwenya, Yawale Iliyasu, Abdullahi Adamu, Mohammed Sani Shehu, Danladi Amodu Ameh, Sirajo Mohammed Aminu, Saad Aliyu Ahmed, John Idoko, Atara Ntekim, Aishatu Maude Suleiman, Khalid Zahir Shah, Kasimu Umar Adoke
Journal: Cancer Research (2017)

Abstract Studies have shown improved/increased intake of dietary fiber and low fecal pH are associated with a lowered risk for colorectal cancer. This study aimed to compare dietary fiber intake, fecal neutral detergent fiber (NDF) content, acid detergent fiber (ADF), cellulose, hemicellulose, lignin and fecal pH level of colorectal cancer patients and matched apparently healthy control group in rural Africans in Zaria, Nigeria. Twenty-one subjects of mean age 44.7 years who are diagnosed with colorectal cancer by histology and 14 apparently healthy matched control groups with mean age 45.2 years were recruited for this study. A predefined semi structured food frequency questionnaire (FFQ) was used to access the dietary fiber intake by the subjects. The fecal NDF content was analyzed by extracting 1 g of fecal sample with a mixture of ethanol/ether and refluxed with decalin and sodium sulphite. The extract was suctioned and washed with acetone to yield the total NDF. The NDF was refluxed with an acid detergent solution and dried overnight to yield the ADF. The differences in the NDF and ADF gave the total hemicelluloses. The differences in the weight of the ADF post-treatment with permanganate solution yielded the total lignin. The differences in weight of the permanganate residue post-treatment with 72% Sulphuric acid gave the cellulose content. A pH meter calibrated with buffers of pH 4 and 7 was used to measure the fecal pH of all the subjects. Results from the FFQ show all subjects consumed variety of dietary fiber food in significant amount. However, there was a significant difference in the fecal NDF, ADF, hemicellulose, lignin and cellulose contents from the colorectal cancer patients when compared with the control group (p &amp;lt;0.05). So also was there a significant difference in fecal pH between the two groups (p &amp;lt;0.05). Consumption of dietary fiber rich foodstuffs alone may not be adequate for prevention against colorectal cancer incidence in some rural Africans in Zaria. There is a need to look into other associating factors which, might have been contributing to colorectal cancer incidence/increase in rural African population. Citation Format: Mohammed Faruk, Sani Ibrahim, Ahmed Adamu, Abdulmumini Hassan Rafindadi, Yahaya Ukwenya, Yawale Iliyasu, Abdullahi Adamu, Mohammed Sani Shehu, Danladi Amodu Ameh, Sirajo Mohammed Aminu, Saad Aliyu Ahmed, John Idoko, Atara Ntekim, Aishatu Maude Suleiman, Khalid Zahir Shah, Kasimu Umar Adoke. Dietary-fiber and fecal fiber contents including pH in rural Africans with colorectal cancer [abstract]. In: Proceedings of the AACR International Conference: New Frontiers in Cancer Research; 2017 Jan 18-22; Cape Town, South Africa. Philadelphia (PA): AACR; Cancer Res 2017;77(22 Suppl):Abstract nr A19.