tbuckley/cabot-search huggingface dataset:
Soft and Moldable Mg‐Doped Liquid Metal for Conformable Skin Tumor Photothermal Therapy
Authors: Xuelin Wang, Wenhao Yao, Rui Guo, Xiaohu Yang, Jianbo Tang, Jie Zhang, Weiping Gao, Victoria Timchenko, Jing Liu
Journal: Advanced Healthcare Materials (2018)

As a class of emerging multifunctional soft materials, gallium-based liquid metal (LM) amalgams, metal/nonmetal particles dispersed in an LM environment, suggest a combination of intriguing properties. In this article, Mg particles in gallium-indium alloy for making new conceptual biomedical materials, which can adapt to any irregular skin surface, are introduced, and superior photothermal effect with a 61.5% photothermal conversion (PTC) increase with respect to that of the LM is realized. The formation of a new intermetallic phase Mg2 Ga5 and adjustable surface roughness, which guarantees a rapid temperature increase when illuminated by laser, are found to be responsible for the photothermal effect enhancement. The obtained soft metallic mixtures also possess excellent thermal conductivity, favorable formability, together with benign biocompatibility. The potential use of the currently produced LM mixtures for conformable photothermal therapy (PTT) of skin tumors, which is hard to precisely heat otherwise via conventional ways, is explored. The soft Mg-GaIn mixtures can adapt to irregular tumor shapes to achieve conformable and minimal invasive tumor treatment. In vivo experiments on skin-tumor-bearing mice show obvious tumor growth suppression and life span extension after PTT treatment. As a novel functional PTC material, the Mg-GaIn mixtures exhibit promising potentials in the coming clinical cancer theranostics.
Endoscopic ultrasound elastography of small solid pancreatic lesions: a multicenter study
Authors: Andre Ignee, Christian Jenssen, Paolo G. Arcidiacono, Michael Hocke, Kathleen Möller, Adrian Saftoiu, Uwe Will, Pietro Fusaroli, Julio Iglesias-Garcia, Ryan Ponnudurai, Maria C. Petrone, Barbara Braden, Eike Burmester, Yi Dong, Nathan S. Atkinson, Christoph F. Dietrich
Journal: Endoscopy (2018)

The prevalence of malignancy in patients with small solid pancreatic lesions is low; however, early diagnosis is crucial for successful treatment of these cases. Therefore, a method to reliably distinguish between benign and malignant small solid pancreatic lesions would be highly desirable. We investigated the role of endoscopic ultrasound (EUS) elastography in this setting.Patients with solid pancreatic lesions ≤ 15 mm in size and a definite diagnosis were included. Lesion stiffness relative to the surrounding pancreatic parenchyma, as qualitatively assessed and documented at the time of EUS elastography, was retrospectively compared with the final diagnosis obtained by fine-needle aspiration/biopsy or surgical resection.218 patients were analyzed. The average size of the lesions was 11 ± 3 mm; 23 % were ductal adenocarcinoma, 52 % neuroendocrine tumors, 8 % metastases, and 17 % other entities; 66 % of the lesions were benign. On elastography, 50 % of lesions were stiffer than the surrounding pancreatic parenchyma (stiff lesions) and 50 % were less stiff or of similar stiffness (soft lesions). High stiffness of the lesion had a sensitivity of 84 % (95 % confidence interval 73 % - 91 %), specificity of 67 % (58 % - 74 %), positive predictive value (PPV) of 56 % (50 % - 62 %), and negative predictive value (NPV) of 89 % (83 % - 93 %) for the diagnosis of malignancy. For the diagnosis of pancreatic ductal adenocarcinoma, the sensitivity, specificity, PPV, and NPV were 96 % (87 % - 100 %), 64 % (56 % - 71 %), 45 % (40 % - 50 %), and 98 % (93 % - 100 %), respectively.In patients with small solid pancreatic lesions, EUS elastography can rule out malignancy with a high level of certainty if the lesion appears soft. A stiff lesion can be either benign or malignant.
Abstract 16913: Greater Coronary Atheroma Regression in Women Compared With Men: A Pooled Analysis of Serial Intravascular Ultrasonography Trials Utilizing High-intensity Statin Therapy
Authors: Brian Stegman, Mingyuan Shao, Stephen Nichols, Mohamed Elshazly, Samir Kapadia, E. Marat Tuzcu, Steven Nissen, Rishi Puri
Journal: Circulation (2015)

Introduction: High-intensity statin therapy (HIST) reduces cardiovascular events, however sex-related differences in treatment effects are not well characterized, possibly contributing to gender disparities in HIST use. Hypothesis: Sex-related differences in coronary atheroma regression exist following HIST. Methods: We undertook a patient-level post-hoc pooled analysis of 3 randomized trials utilizing serial coronary IVUS to test the anti-atherosclerotic effects of HIST in patients with coronary disease. Sex-related differences in changes (Δ) in coronary percent atheroma volume (PAV) were ascertained following 18-24 months of either atorvastatin 80 mg or rosuvastatin 40 mg. Results: In women (n=451) compared with men (n=1190), levels of on-treatment LDL-C (68±24 vs. 68±22mg/dl, p=0.62) were similar, however HDL-C (53±12 vs. 47±11 mg/dl, p&lt;0.01) and CRP [1.7 (0.9, 3.8) vs. 1.1 (0.6, 2.7) mg/l, p&lt;0.01] were higher. Compared with men, women harbored lower baseline PAV (34.8±8.7 vs. 38.3±8.8%, p&lt;0.001), yet demonstrated greater PAV regression (ΔPAV -1.07±0.26 vs. -0.66±0.23%, p=0.02). When achieved on-treatment LDL-C levels were &lt;70mg/dl, women demonstrated greater PAV regression than men (-1.49±0.21 vs. -0.97±0.13%, p=0.035), however had similar rates of PAV regression with on-treatment LDL-C levels ≥70 mg/dl (-0.63±0.25 vs. -0.42±0.16%, p=0.47). Sex-related differences in atheroma regression did not differ according to achieved levels of HDL-C, non-HDL-C or CRP (Figure). Multivariable analysis revealed female sex to independently associate with PAV regression (coefficient -0.66, p=0.017). Conclusion: Women systematically demonstrate greater degrees of coronary plaque regression compared with men following long-term HIST, especially in the setting of lower achieved LDL-C levels. Further research is required for elucidating mechanisms underpinning sex-related variations in plaque progression-regression.
HEV positivity in domesticated pigs and a relative risk of HEV zoonosis among occupationally exposed individuals in Vietnam
Authors: X.H. Nghiem, X.H. Pham, V.S. Trinh, P.G. Dao, T.B. Mai, T.A. Dam, H.S. Le, C.-T. Bock, T. Hoang, L.T. Nguyen, T.P. Velavan
Journal: Journal of Hepatology (2018)
Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease
Authors: Yongzhi Qiu, Byungwook Ahn, Yumiko Sakurai, Caroline E. Hansen, Reginald Tran, Patrice N. Mimche, Robert G. Mannino, Jordan C. Ciciliano, Tracey J. Lamb, Clinton H. Joiner, Solomon F. Ofori-Acquah, Wilbur A. Lam
Journal: Nature Biomedical Engineering (2018)
Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice
Authors: Xianhong Du, Zhuanchang Wu, Yong Xu, Yuan Liu, Wen Liu, Tixiao Wang, Chunyang Li, Cuijuan Zhang, Fan Yi, Lifen Gao, Xiaohong Liang, Chunhong Ma
Journal: Cellular and Molecular Immunology (2018)
Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis
Authors: Ji Dong, Yuqiong Hu, Xiaoying Fan, Xinglong Wu, Yunuo Mao, Boqiang Hu, Hongshan Guo, Lu Wen, Fuchou Tang
Journal: Genome biology (2018)

Organogenesis is crucial for proper organ formation during mammalian embryonic development. However, the similarities and shared features between different organs and the cellular heterogeneity during this process at single-cell resolution remain elusive. We perform single-cell RNA sequencing analysis of 1916 individual cells from eight organs and tissues of E9.5 to E11.5 mouse embryos, namely, the forebrain, hindbrain, skin, heart, somite, lung, liver, and intestine. Based on the regulatory activities rather than the expression patterns, all cells analyzed can be well classified into four major groups with epithelial, mesodermal, hematopoietic, and neuronal identities. For different organs within the same group, the similarities and differences of their features and developmental paths are revealed and reconstructed. We identify mutual interactions between epithelial and mesenchymal cells and detect epithelial cells with prevalent mesenchymal features during organogenesis, which are similar to the features of intermediate epithelial/mesenchymal cells during tumorigenesis. The comprehensive transcriptome at single-cell resolution profiled in our study paves the way for future mechanistic studies of the gene-regulatory networks governing mammalian organogenesis.
Lipofuscin is detected in early stages of the disease in liver biopsies of patients with Non-Alcoholic Fatty Liver Disease
Authors: R. Morrison, R. Forlano, N. Giannakeas, A. Tzallas, M. Tsipouras, J. Lloyd, M. Yee, M. Thursz, P. Manousou, R.D. Goldin
Journal: Journal of Hepatology (2018)
Virologic control increased overall survival after radiofrequency ablation of hepatocellular carcinoma developed on hepatitis related cirrhosis
Authors: M. Allaire, S. Rekik, L. Richard, A. Mamana, E. Guyot, N. Gisèle, B. Valerie, Véronique Grando, M. Ziol, P. Nahon, N. Ganne-Carrié, O. Sutter, E. Audureau, O. Seror, J. Charles Nault
Journal: Journal of Hepatology (2018)
Pulmonary Hypertension in Patients With Severe Aortic Stenosis: Prognostic Impact After Transcatheter Aortic Valve Replacement
Authors: Brunilda Alushi, Frederik Beckhoff, David Leistner, Marcus Franz, Markus Reinthaler, Barbara E. Stähli, Andreas Morguet, Hans R. Figulla, Torsten Doenst, Francesco Maisano, Volkmar Falk, Ulf Landmesser, Alexander Lauten
Journal: JACC. Cardiovascular imaging (2018)
Long-Term Cardiac, Vascular and Hypertensive Safety of Bosutinib in Patients with Philadelphia Chromosome-Positive (Ph+) Leukemia Resistant or Intolerant to Prior Therapy
Authors: Jorge E. Cortes, Dong-Wook Kim, Hagop M. Kantarjian, Michael J. Mauro, Jean M. Aguiar, Fiona An, Eric Leip, Carlo Gambacorti-Passerini, Tim H. Brummendorf
Journal: Blood (2017)
Early Weight Gain in Pregnancy and Infant Birth Weight—Reply
Authors: Ravi Retnakaran, Shi Wu Wen, Hongzhuan Tan
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Effect of Endocuff-assisted colonoscopy on adenoma detection rate: meta-analysis of randomized controlled trials
Authors: Nicolas Williet, Quentin Tournier, Chloé Vernet, Olivier Dumas, Leslie Rinaldi, Xavier Roblin, Jean-Marc Phelip, Mathieu Pioche
Journal: Endoscopy (2018)

Abstract Background Yield of Endocuff-assisted colonoscopy (EAC) compared with standard colonoscopy is conflicting in terms of adenoma detection rate (ADR). A meta-analysis of randomized controlled trials (RCTs) appears necessary. Methods PubMed and Google Scholar were searched in December 2017. Abstracts from Digestive Disease Week and United European Gastroenterology Week meetings were also searched to 2017. All RCTs comparing EAC with standard colonoscopy were included. Analysis was conducted by using the Mantel–Haenszel models. Heterogeneity was quantified using the I 2 test. Results Of the 265 articles reviewed, 12 RCTs were included, with a total of 8376 patients (EAC group 4225; standard colonoscopy group 4151). In the meta-analysis, ADR was significantly increased in the EAC group vs. the standard colonoscopy group (41.3 % vs. 34.2 %; risk ratio [RR] = 1.20, 95 % confidence interval [CI] 1.06 to 1.36; P = 0.003; I 2 = 79 %), especially for operators with low-to-moderate ADRs (&lt; 35 %): RR = 1.51, 95 %CI 1.35 to 1.69; P &lt; 0.001; I 2 = 43 %). In contrast, this benefit was not reached for operators with high ADRs (&gt; 45 %): RR = 1.01, 95 %CI 0.93 to 1.09; P = 0.87; I 2 = 0.0 %). The mean number of adenomas per patient tended to be higher with EAC (mean difference = 0.11 adenomas/patient, 95 %CI – 0.17 to 0.38). Similar results were shown for polyp detection rates (61.6 % vs. 51.4 %; RR = 1.20, 95 %CI 1.06 to 1.36; P = 0.004). Use of the Endocuff did not impact the cecal intubation rate (95.1 % vs. 95.7 %; P = 0.08), or the procedure time compared with standard colonoscopy. Adverse events related to Endocuff were rare and exclusively mild mucosal erosion (4.0 %; 95 %CI 2.0 % to 8.0 %). Conclusion With moderate-quality evidence, this study showed an improvement in ADR with EAC without major adverse events, especially for operators with low-to-moderate ADRs.
Acute-on-chronic liver failure is characterised by hepatocyte gasdermin D cleavage and release of the pro-inflammatory Damage Associated Molecular Pattern (DAMP) IL-α
Authors: U. Soffientini, N. Beaton, A. Habtesion, E. Weiss, V. Paradis, A. Nadar, N. Davies, R. Williams, S. Chokshi, R. Moreau, R. Jalan, G. Mehta
Journal: Journal of Hepatology (2018)
Abstract 13761: Single Nucleotide Polymorphism of Mlx Gene Causes Txnip Accumulation and Inflammasome Formation, Thereby Promoting the Development of Takayasu Arteritis
Authors: Natsuko Tamura, Yasuhiro Maejima, Mitsuaki Isobe
Journal: Circulation (2015)

Introduction: We have previously conducted genome-wide association study of Takayasu arteritis(TA) and revealed that single nucleotide polymorphism (SNP) of MLX ,a gene encoding MLX transcription factor, was markedly associated with clinical phenotypes of TA. Recently, we also have shown that SNP of the MLX (rs665268), a missense mutation of MLX that alters the 139 th glutamine to arginine (Q139R) on MLX facilitates the heterodimer formation of MLX with MondoA, which in turn promoting transcription of the thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of thioredoxin. However, it remains unknown how upregulation of TXNIP caused by SNP of MLX is associated with the pathogenesis of TA. Hypothesis: Accumulation of TXNIP caused by mutation of MLX-Q139R plays an important role in the development of TA. Methods and Results: The protein level of NLRP3, a major component of inflammasome, as well as that of TXNIP was significantly accumulated (TXNIP: 4.5 fold, NLRP3: 3.8 fold) in human aortic smooth muscle cells(hASMCs) transfected with MLX-Q139R plasmid than compared to those in transfected with wild-type MLX plasmid. Immunostaining demonstrated that both NLRP3 and TXNIP accumulated more prominently in the SMCs of aortas of TA than in normal aortas, suggesting that increased level of TXNIP by MLX-Q139R mutation is associated with accumulation of NLRP3 in hASMCs. To address the consequence of MLX-Q139R mutation on inflammatory cells, we isolated human peripheral blood mononuclear cells (hPBMCs) from TA patients and normal subjects. Treatment of IL-12 significantly enhanced the protein level of both TXNIP and caspase-1, another main component of inflammasome, in T lymphocytes differentiated from hPBMCs of TA patients compared to those from normal subjects. We conducted in vitro proliferation assays of hASMCs co-cultured with hPBMCs. hASMCs significantly proliferated when hPBMCs from normal subjects were co-cultured, and this proliferation was more prominent when hASMCs were co-cultured with hPBMCs from TA patients. Conclusion: The increase of TXNIP caused by MLX-Q139R mutation promotes inflammasome formation in both hASMCs and hPBMCs, thereby facilitating proliferation of hASMCs, a pathological manifestation seen in the aortas of TA.
Cancer Treatment: Two‐Photon‐Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment (Adv. Healthcare Mater. 7/2018)
Authors: Jonas G. Croissant, Jeffrey I. Zink, Laurence Raehm, Jean‐Olivier Durand
Journal: Advanced Healthcare Materials (2018)

Two-photon-absorbing (2hνA) nanoparticles provide safer cancer treatment opportunities than current therapies lacking spatial and temporal selectivity thanks to their 3D spatial resolution and very low scattering. In article number 1701248, Jonas G. Croissant and co-workers describe porous and nonporous 2hνA silica, organosilica, and gold-silica nanoparticles for bio-imaging, drug delivery, and photodynamic therapy via photolysis, energy transfer, and electron transfer mechanisms.
HER2 Amplification in Tumors Activates PI3K/Akt Signaling Independent of HER3
Authors: Ana Ruiz-Saenz, Courtney Dreyer, Marcia R. Campbell, Veronica Steri, Nate Gulizia, Mark M. Moasser
Journal: Cancer Research (2018)

Current evidence suggests that HER2-driven tumorigenesis requires HER3. This is likely due to the unique ability of HER3 to activate PI3K/Akt pathway signaling, which is not directly accessible to HER2. By genetic elimination of HER3 or shRNA knockdown of HER3 in HER2-amplified cancer cells, we find residual HER2-driven activation of PI3K/Akt pathway signaling that is driven by HER2 through direct and indirect mechanisms. Indirect mechanisms involved second messenger pathways, including Ras or Grb2. Direct binding of HER2 to PI3K occurred through p-Tyr1139, which has a weak affinity for PI3K but becomes significant at very high expression and phosphorylation. Mutation of Y1139 impaired the tumorigenic competency of HER2. Total elimination of HER3 expression in HCC1569 HER2-amplified cancer cells significantly impaired tumorigenicity only transiently, overcome by subsequent increases in HER2 expression and phosphorylation with binding and activation of PI3K. In contrast to activation of oncogenes by mutation, activation by overexpression was quantitative in nature: weak intrinsic activities were strengthened by overexpression, with additional gains observed through further increases in expression. Collectively, these data show that progressive functional gains by HER2 can increase its repertoire of activities such as the activation of PI3K and overcome its dependency on HER3.Significance: The intrinsic ability of HER2 to activate PI3K correlates with increased HER2 expression and can supplant the dependency upon HER3 for growth in HER2-amplified cancers. Cancer Res; 78(13); 3645-58. ©2018 AACR.
Tumor Lysis Syndrome
Authors: Arjun Gupta, Joseph A. Moore
Journal: JAMA Oncology (2018)

Tumor Lysis SyndromeTumor lysis syndrome (TLS) is a condition that occurs when a large number of cancer cells die within a short period, releasing their contents in to the blood.How Does TLS Affect the Body?When cancer cells break down quickly in the body, levels of uric acid, potassium, and phosphorus rise faster than than the kidneys can remove them.This causes TLS.Excess phosphorus can "sop up" calcium, leading to low levels of calcium in the blood.Changes in blood levels of uric acid, potassium, phosphorus, and calcium can affect the functioning of several organs, especially the kidneys, and also the heart, brain, muscles, and gastrointestinal tract.
Respiratory mortality of childhood, adolescent and young adult cancer survivors
Authors: Miranda M Fidler, Raoul C Reulen, Chloe J Bright, Katherine E Henson, Julie S Kelly, Meriel Jenney, Antony Ng, Jeremy Whelan, David L Winter, Clare Frobisher, Michael M Hawkins
Journal: Thorax (2018)

Background Exposure to radiation and/or chemotherapy during cancer treatment can compromise respiratory function. We investigated the risk of long-term respiratory mortality among 5-year cancer survivors diagnosed before age 40 years using the British Childhood Cancer Survivor Study (BCCSS) and Teenage and Young Adult Cancer Survivor Study (TYACSS). Methods The BCCSS comprises 34 489 cancer survivors diagnosed before 15 years from 1940 to 2006 in Great Britain. The TYACSS includes 200 945 cancer survivors diagnosed between 15 years and 39 years from 1971 to 2006 in England and Wales. Standardised mortality ratios and absolute excess risks were used. Findings Overall, 164 and 1079 respiratory deaths were observed in the BCCSS and TYACSS cohorts respectively, which was 6.8 (95% CI 5.8 to 7.9) and 1.7 (95% CI 1.6 to 1.8) times that expected, but the risks varied substantially by type of respiratory death. Greatest excess numbers of deaths were experienced after central nervous system (CNS) tumours in the BCCSS and after lung cancer, leukaemia, head and neck cancer and CNS tumours in the TYACSS. The excess number of respiratory deaths increased with increasing attained age, with seven (95% CI 2.4 to 11.3) excess deaths observed among those aged 50+ years in the BCCSS and three (95% CI 1.4 to 4.2) excess deaths observed among those aged 60+ years in the TYACSS. It was reassuring to see a decline in the excess number of respiratory deaths among those diagnosed more recently in both cohorts. Conclusions Prior to this study, there was almost nothing known about the risks of respiratory death after cancer diagnosed in young adulthood, and this study addresses this gap. These new findings will be useful for both survivors and those involved in their clinical management and follow-up.
2018 ACC/HRS/NASCI/SCAI/SCCT Expert Consensus Document on Optimal Use of Ionizing Radiation in Cardiovascular Imaging: Best Practices for Safety and Effectiveness
Authors: John W. Hirshfeld, Victor A. Ferrari, Frank M. Bengel, Lisa Bergersen, Charles E. Chambers, Andrew J. Einstein, Mark J. Eisenberg, Mark A. Fogel, Thomas C. Gerber, David E. Haines, Warren K. Laskey, Marian C. Limacher, Kenneth J. Nichols, Daniel A. Pryma, Gilbert L. Raff, Geoffrey D. Rubin, Donnette Smith, Arthur E. Stillman, Suma A. Thomas, Thomas T. Tsai, Louis K. Wagner, L. Samuel Wann
Journal: Journal of the American College of Cardiology (2018)
J Dennis Wilson
Authors: Chris Nolan
Journal: BMJ (2018)

J Dennis Wilson qualified in Belfast, Northern Ireland, and completed his training as an endocrinologist at the Royal Victoria Hospital in 1979. He completed an MD at Queen’s that same year and moved to Melbourne as a clinical fellow at the medical research centre, Prince Henry’s Hospital. Dennis was appointed staff endocrinologist at the Woden Valley Hospital in Canberra in 1980. He was clinical director of endocrinology from 1990 and continued …