tbuckley/cabot-search huggingface dataset:
Abstract #1339: Methylation of p16 CpG island associated with malignant transformation of oral epithelial dysplasia: a prospective cohort study
Authors: Jie Cao, Yan Gao, Jing Zhou, Hongwei Wu, Dajun Deng
Journal: Cancer Research (2009)

Background: Identification of malignant potential of oral epithelial dysplasia (OED) is virtually impossible on histopathological grounds alone. Inactivation of  p16  gene by CpG methylation is an early frequent event during carcinogenesis. To investigate predictive value of  p16  methylation on malignant potential of OED, we carried out a prospective cohort study. Methods: 101 patients with histologically proven mild or moderate OED were included in the present study. Baseline information of  p16  methylation of the OED lesions from 93 cases was obtained by methylation-specific PCR. The average followup time was 45.8 months. Progression of the OED lesions was examined histologically during the double-blind followup survey, with the compliance of 83.9% (78/93). SPSS13.0 software was used to do univariate and multivariate analysis. All P-values were two-sided. Results:  p16  methylation was detectable in OED lesions from 32 of 78 (41.0%) enrolled patients. OED related squamous cell carcinomas were observed in 22 patients (28.2%) during the followup histologically. Canceration rate (43.8%, 14/32) in patients with the  p16 -methylated OED was significant higher than that (17.4%, 8/46) in cases with the  p16 -unmethylated OED (odds ratio [OR] =3.7; adjusted  P =0.013), especially for patients at the baseline age of more than 60 yrs (OR=12.0;  P  p16  methylation were 63.6% (14/22) and 67.9% (38/56), respectively. Conclusion:  p16  methylation was correlated with canceration of OED independently and a potential biomarker for prediction of malignant transformation of mild or moderate OED.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 1339.
KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis
Authors: Meera Murgai, Wei Ju, Matthew Eason, Jessica Kline, Daniel W Beury, Sabina Kaczanowska, Markku M Miettinen, Michael Kruhlak, Haiyan Lei, Jack F Shern, Olga A Cherepanova, Gary K Owens, Rosandra N Kaplan
Journal: Nature Medicine (2017)
AB0442 Real-life experience with belimumab in systemic lupus erythematosus (SLE): control of disease activity and flares in a multicenter cohort
Authors: A Fanouriakis, C Adamichou, S Koutsoviti, A Klagou, C Tsalapaki, S Konsta, D Dimopoulou, S Ntali, D Vassilopoulos, P Konstantopoulou, A Elezoglou, P Sidiropoulos, A Erden, G Bertsias, D Boumpas
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Data on the efficacy of belimumab in SLE mainly originate from large randomized clinical trials, whereas reports from real-life clinical practice are lacking. <h3>Objectives</h3> To describe the clinical experience from the use of belimumab in Greece since the approval of the drug. <h3>Methods</h3> Multicentre observational study of patients receiving belimumab, with documentation of disease activity (SLEDAI-2K index), achievement of low disease activity states [remission (SLEDAI-2K=0) and lupus low disease activity state (LLDAS)], accrual of irreversible damage (SLICC damage index, SDI), number and severity of flares, and side-effects. Analyses were performed at quarterly intervals and only patients with at least 3 months of follow-up were included in the study. <h3>Results</h3> A total of 56 patients were included [53 women (94.6%), mean (SD) age 46.3 (12.7) years]. Evidence of serologic activity (low C3/C4 and/or high anti-ds DNA) was evident in 30 patients (53.5%). Most frequent manifestations were arthritis (82.1%), inflammatory rash (73.2%), active hair loss (57.1%), mucosal ulcers (26.8%) and leukopenia (10.7%). Median (range) duration of follow-up was 9.1 (2.9 - 34.6) months. We observed a significant decrease in the SLEDAI-2K, physician global assessment (PGA) and daily prednisone dose over time, starting as early as 3 months after belimumab initiation (Table 1). This effect was significantly more pronounced in patients who were serologically active (SA) at baseline, even after exclusion of the serologic component of the SLEDAI [median (range) <i>clinical</i> SLEDAI-2K for SA patients: 7 (1–24) at baseline vs. 2 (0–16) at 6 months and 2 (0–16) at 12 months, p&lt;0.0001 and p=0.013, respectively; for serologically inactive patients: 6 (2–23) at baseline vs. 6 (0–14) at 6 months and 5 (0–18) at 12 months, p=0.017 and p=0.024, respectively]. For patients with ≥12 months of follow-up (n=20), belimumab treatment resulted in a significant decrease in flare rate [median (range) total number of flares for the 12 months before and after belimumab treatment, 3 (0–7) and 0 (0–2), respectively, p&lt;0.0001). 10 patients (17.8%) discontinued belimumab due to inefficacy after a median (range) 7.1 (5.5 - 20.4) months of therapy and 5 patients discontinued due to planned pregnancy. There were no drug discontinuations due to side-effects. <h3>Conclusions</h3> In real-life clinical settings, belimumab is efficacious in controlling disease activity of SLE and permitting tapering of glucocorticoid dose. Similar to data from RCTs, this effect seems to be more pronounced in serologically active patients. <h3>Disclosure of Interest</h3> None declared
アルファ粒子放射線療法:大規模固体腫瘍は拡散に勝る標的化のために【Powered by NICT】
Authors: Zhu Charles, Sempkowski Michelle, Holleran Timothy, Linz Thomas, Bertalan Thomas, Josefsson Anders, Bruchertseifer Frank, Morgenstern Alfred, Sofou Stavroula
Journal: Biomaterials (2017)
Multivariate and network meta-analysis of multiple outcomes and multiple treatments: rationale, concepts, and examples
Authors: Richard D Riley, Dan Jackson, Georgia Salanti, Danielle L Burke, Malcolm Price, Jamie Kirkham, Ian R White
Journal: BMJ (2017)

Organisations such as the National Institute for Health and Care Excellence require the synthesis of evidence from existing studies to inform their decisions—for example, about the best available treatments with respect to multiple efficacy and safety outcomes. However, relevant studies may not provide direct evidence about all the treatments or outcomes of interest. Multivariate and network meta-analysis methods provide a framework to address this, using correlated or indirect evidence from such studies alongside any direct evidence. In this article, the authors describe the key concepts and assumptions of these methods, outline how correlated and indirect evidence arises, and illustrate the contribution of such evidence in real clinical examples involving multiple outcomes and multiple treatments
Communication as the Key to Breast Conservation
Authors: Julie A. Margenthaler, Amy E. Cyr
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Major report backs overhaul of US dietary guideline process
Authors: Jacqui Wise
Journal: BMJ (2017)

The process for updating the US national dietary guidelines should be comprehensively redesigned, with more rigorous evaluation of the evidence and greater transparency, concludes a new report from the National Academies of Sciences, Engineering and Medicine.1

The Dietary Guidelines for Americans , issued every five years, are hugely influential in driving nutrition policy in the United States and worldwide. However, they have been heavily criticized in recent years, and concerns have been raised in the US Congress about their trustworthiness.

In 2015 The BMJ ran a highly critical review saying that the expert report underpinning the dietary guidelines failed to take account of all the relevant scientific evidence.2 In response, more than 180 researchers, including all the members of the 2015 guideline committee, signed a letter calling on The BMJ to retract the article. After a formal post-publication review The BMJ decided against retraction.3

In response to widespread criticism, Congress asked the National Academies of Sciences, Engineering and Medicine to evaluate the entire process used to develop …
AB0024 A novel real-time imaging technique to characterize mechanisms of cell death in neutrophils
Authors: S Gupta, DW Chan, KJ Zaal, E Ralston, MJ Kaplan
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Neutrophils play a key role in the pathogenesis of autoimmune diseases through various mechanisms including the formation of neutrophil extracellular traps (NETs). NETosis, a recently described distinct form of program neutrophil cell death, is characterized by reactive oxygen species generation, chromatin and nuclear decondensation, membrane rupture and extrusion of a meshwork of chromatin bound to granule peptides. <h3>Objectives</h3> Techniques to assess and quantitate NETosis in an unbiased, reproducible and efficient way are lacking. We developed a new method to automatically quantify the percentage of neutrophils undergoing NETosis using real-time quantitative live-cell analysis with IncuCyte ZOOM™ (Essen BioScience, Inc.) platform and a dual-dye system dependent on membrane integrity to stain DNA, to image neutrophils and characterize their mechanisms of cell death. <h3>Methods</h3> Neutrophils were isolated from healthy controls using density gradient methods and their DNA was stained with a membrane permeable NUCLEAR-ID Red DNA dye. Neutrophils were plated and incubated with various stimuli to induce NETosis (PMA, ionomycin and/or SLE sera), apoptosis (Staurosporin) or necroptosis (TNF with a pan-caspase inhibitor, Z-VAD) and with Sytox, a membrane-impermeable DNA dye. Three 20x magnification images from different areas per well were captured at 10-minute intervals. A processing definition was set and optimized to count all neutrophils (NUCLEAR-ID stained) at baseline and neutrophils undergoing cell death (Sytox stained) at three hours using fluorescence intensity and stained area size (Figure 1). <h3>Results</h3> Percentage of neutrophils undergoing cell death using various stimuli was highly reproducible. Characterization of changes in nuclear morphology, quantified by the processing definition, distinguished between NETosis, apoptosis and necroptosis. Findings were confirmed and counts correlated with previously established method using immunofluorescence microscopy. <h3>Conclusions</h3> This novel real time assay distinguishes types of neutrophil cell death and quantifies NETosis in a rapid, accurate and reproducible way. This technique may facilitate studies in neutrophil biology. <h3>Disclosure of Interest</h3> None declared
Film: Indian film-maker tackles hypochondriasis
Authors: Sanjit Bagchi
Journal: BMJ (2006)

A film currently showing in India deals with an often ignored but growing health issue in the country—hypochondriasis. Shaadi se Pehle (which means “before the marriage” in Hindi) depicts the havoc that the condition can cause in the life of a successful businessman. Aashish Kapoor (elegantly played by Indian actor Akshaye Khanna) is a talented advertising executive, well known for coming up with creative ideas at the agency where he works. But, despite doing so well professionally, he constantly feels unwell even though he has no obvious illness. His hypochondriasis and constant concerns about his health gradually start to change his life. He tries a range of different medicines and his behaviour changes to that of someone who is sick.

Despite consulting a doctor who confirms that he's perfectly healthy, Kapoor remains unconvinced. Things escalate still further when he overhears the doctor making a phone call about another patient and mistakenly thinks it is about him, so starts believing that he has end-stage cancer. Fearing that he hasn't got much longer to live, the now very depressed man decides to leave his girlfriend, even though he loves her deeply, so that she can have a better life. His life sinks into a trough of depression, dominated by thoughts about death.​death.



Figure 1

“Think positively, live life”



But—as in all good Bollywood films—there is a happy ending. Kapoor is eventually convinced by his doctor that he does not have cancer. He realises that his negative thoughts are making him ill and acts on his doctor's advice: “Think positively, live life.” In true romantic style, he regains his girlfriend's love.

In a relatively poor, developing country such as India, people pay less importance to psychiatric conditions than to physical illnesses. Psychiatric problems are now increasing sharply and there have been a large number of suicides in recent years. It has been projected that developing countries will suffer a major increase in the burden of mental illness over the next two decades. Hypochondriasis—defined as a persistent, non-delusional preoccupation with fears of having severe physical disease despite appropriate medical evaluation and reassurance—may seem relatively minor, but it can seriously impair patients' quality of life. It may also be associated with other psychiatric disorders and so should not be ignored.

Shaadi se Pehle wraps up some useful factual information about hypochondriasis in a humorous format. Apart from some cinematic exaggeration in places, the film accurately portrays the “nitty-gritty” of the condition from an Indian perspective. Films are considered a powerful medium for mass communication in India, so Kapoor's story should improve public awareness about hypochondriasis. It also reminds health professionals of the need to look out for, and help patients to manage, this common but overlooked condition.
SP0163 Interventions to improve medication adherence in patients with inflammatory arthritis
Authors: JE Vriezekolk
Journal: Annals of the Rheumatic Diseases (2017)

Non-adherence to medication in rheumatic diseases is a major concern for patient9s health, because incorrect use can result in <i>less</i> therapeutic benefits of treatment, including more disease activity and increased radiological damage. As a consequence, non-adherence may lead to more disability and lower health-related quality of life. Using Lowe9s taxonomy<sup>1</sup>, the current state of evidence around medication adherence interventions will be presented. Examples of promising intervention strategies will be highlighted. <h3>References</h3> Lowe et al. (2011) Development of a taxonomy of interventions to organise the evidence on consumers9 medicine use. <h3>Disclosure of Interest</h3> None declared
STP savings plans are “not credible,” think tanks warn
Authors: Tom Moberly
Journal: BMJ (2017)

Plans to reduce NHS costs in London are “not credible,” and more radical cuts to services may need to be considered to deliver savings, leading healthcare think tanks have warned.

As part of work commissioned by the London mayor Sadiq Khan, the King’s Fund, and the Nuffield Trust analysed plans published by the five London based sustainability and transformation partnerships (STPs). The think tanks concluded that, without appropriate action, the NHS in London would face a gap of £4.1bn (€4.5bn; $5.4bn) by 2020-21 between the funding it receives and the …
SAT0064 High MMP3 serum levels are associated with extensive structural damage in patients with early, treatment naive rheumatoid arthritis (RA): two years prospective clinical and ultrasonographic study
Authors: SZ Prodanovic, G Radunovic, M Sefik-Bukilica, M Zlatanovic, K Simic-Pasalic, S Seric, N Damjanov
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Objectives</h3> To investigate the association of high baseline MMP-3 serum levels with hands and feet joints structural damage progression, estimated by ultrasonography (US), in patients with early, treatment "naïve" RA without X-ray visible erosions. <h3>Methods</h3> Sixty-three pts. (9 males and 54 females; mean age 53.4 yrs 21–81±14.1) with early RA (EULAR/ACR 2010 criteria) and symptom duration of ≤12 months (mean duration of 3.8 months) had baseline serum MMP-3 levels tested. Patients had been DMARDs/glucocorticoid naïve, without visible X-ray erosions at the study entry. The subsequent structural joints damages, that were estimated by high frequency linear probe by ESAOTE My Lab 70 machine, as well as clinical markers of disease activity, in the first 2 years were followed. The presence of bone erosion was analyzed at the wrist, MCP2 and MCP5 joints of both hands, as well as at MTP5 joints according to OMERACT US group definition. In order to estimate progression of preexisting erosion the total volume (TV) of bone erosion were calculated by multiplying three diameters (mm): a-the length of erosion; diameter b- the width and diameter c-the depth of erosion. Anova statistical method was performed in data processing. <h3>Results</h3> 46 pts. had basal serum MMP-3 level higher than normal (MMP-3 positive). The 504 joints were assessed summary by US on each visit. The 122 bone erosions in total (1.9 per patient) were depicted at baseline and 213 bone erosions (4.3 per patient) at follow-up visit in whole group. After 24 months MMP3 positive pts. had significantly higher total number of US erosions than MMP-3 negative (3.8 vs. 2.4, p=0.039). The total volume of bone erosion (mm<sup>3</sup>) was higher in MMP-3 positive than MMP-3 negative pts. after 24 months of treatment, but without statistical significance (18.6 vs. 8.9, p=0.07). MMP-3 positive pts. had a significantly higher value of ESR, CRP and DAS28 than MMP-3 negative pts. at the baseline visit (53.6 vs.25.9, p=0.002; 36.6 vs. 9.5, p=0.005; 6.0 vs. 4.8, p=0.002, respectively). All of those parameters were significantly decreased after 24 months in a group of MMP-3 positive compared to MMP-3 negative pts. (p=0.009, p=0.021, p=0.028, respectively). <h3>Conclusions</h3> After 2-year of follow-up, US assessment showed a significantly higher number of new bone erosions in patients with early, treatment "naïve" RA and baseline MMP3 levels higher than normal (MMP3 positive) compared to patients with normal baseline levels of MMP3, as well as a biger TV of bone erosions but not statistically significant. The parameters of RA activity (ESR, CRP, DAS28) significantly correlated with baseline MMP-3 levels of higher than normal. <h3>Disclosure of Interest</h3> None declared
The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study
Authors: J. Bousquet, S. Arnavielhe, A. Bedbrook, J. Fonseca, M. Morais Almeida, A. Todo Bom, I. Annesi‐Maesano, D. Caimmi, P. Demoly, P. Devillier, V. Siroux, E. Menditto, G. Passalacqua, C. Stellato, M. T. Ventura, A. A. Cruz, F. Sarquis Serpa, J. da Silva, D. Larenas‐Linnemann, M. Rodriguez Gonzalez, M. T. Burguete Cabañas, K. C. Bergmann, T. Keil, L. Klimek, R. Mösges, S. Shamai, T. Zuberbier, M. Bewick, D. Price, D. Ryan, A. Sheikh, J. M. Anto, J. Mullol, A. Valero, T. Haahtela, E. Valovirta, W. J. Fokkens, P. Kuna, B. Samolinski, C. Bindslev‐Jensen, E. Eller, S. Bosnic‐Anticevich, R. E. O'Hehir, P. V. Tomazic, A. Yorgancioglu, B. Gemicioglu, C. Bachert, P. W. Hellings, I. Kull, E. Melén, M. Wickman, M. van Eerd, G. De Vries
Journal: Allergy (2017)

Mobile technology has been used to appraise allergic rhinitis control, but more data are needed. To better assess the importance of mobile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score ranging from 0 to 4 of the Allergy Diary was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity and Activity Impairment in allergy) in 1288 users in 18 countries. This study showed that quality-of-life data (EQ-5D visual analogue scale and WPA-IS Question 9) are similar in users without rhinitis and in those with mild rhinitis (scores 0-2). Users with a score of 3 or 4 had a significant impairment in quality-of-life questionnaires.
THU0603 Disease burden of knee osteoarthritis patients undergoing joint replacement compared to matched controls: a population-based analysis of a dutch medical claims database
Authors: JTH Nielen, A Boonen, PC Dagnelie, B van den Bemt, P Emans, F Lafeber, WE van Spil, F de Vries, P Welsing
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Knee osteoarthritis (OA) is a progressive joint disease generally associated with increasing pain. In severe symptomatic knee OA, knee prosthesis (KP) can improve health-related quality of life. In the Netherlands, the incidence of KPs and KP revisions has increased, but health care costs related to these procedures over time and their determinants are unknown.<sup>1</sup> <h3>Objectives</h3> To provide estimates of age and sex-specific incidence of KPs, revision KPs, and prosthesis complications in patients with knee OA. To determine average annual health care costs of patients undergoing KP compared with matched controls in the Netherlands, and to understand drivers of costs. <h3>Methods</h3> All KPs in knee OA patients in the Achmea Health Database were identified and matched by age, sex, and region to a maximum of four controls. Incidence rates of KPs, KP revisions, and their complications (/1000 persons) from 2006–2013 were determined. Annual health care cost and excess costs compared to matched controls, preceding, during and after surgery were calculated and associated factors evaluated using longitudinal regression analysis. <h3>Results</h3> The incidence of KPs, KP revisions, and complications increased between 2006 and 2013. This increase was strongest in younger age categories and in men (Table 1). Annual health care costs slightly increased up to the year of surgery, with highest costs in the year of surgery. Post-surgery costs remained slightly higher than pre-surgery costs. High post-surgery costs were mainly associated with subsequent KPs. Other factors associated with high excess costs were younger age, female gender, and complications. <h3>Conclusions</h3> These results underscore the increasing burden associated with severe knee OA, especially in younger age categories. Improved guidelines aimed at avoiding complications and revisions are required to counteract this trend. <h3>References</h3> Dutch Arthroplasty Register (LROI). Arthroplasty in the Picture, Annual Report of the Dutch Arthroplasty Register. 2014. <h3>Disclosure of Interest</h3> None declared
Relapse Risk Score after Allogeneic Stem Cell Transplantation for MDS Patients. an EBMT Study from the MDS Subcommittee of Chronic Malignancies Working Party (CMWP)
Authors: Nicolaus Kröger, Hein Putter, Liesbeth De Wreede, Anja van Biezen, Dimitris Ziagkos, Liisa Volin, Johan Maertens, Jürgen Finke, Per T. Ljungman, Nigel H. Russell, Ibrahim Yakoub-Agha, Michel Schaap, Charles Craddock, Ghulam J Mufti, Patrice Chevallier, Jakob R Passweg, Noel Milpied, Didier Blaise, Jean-Henri Bourhis, Tobias Gedde-Dahl, Carlos Richard Espiga, Jan J. Cornelissen, Gudrun Göhring, Johannes Schetelig, Theo de Witte, Marie Robin
Journal: Blood (2016)