tbuckley/cabot-search huggingface dataset:
Abstract 13486: Patient and Procedural Factors Are Associated With Autonomic and Endothelial Dysfunction in Adolescent and Young Adult Fontan Survivors
Authors: Bryan H Goldstein, Bradley S Marino, Zhiqian Gao, Philip R Khoury, Michelle A Amos, Wayne A Mays, Gruschen R Veldtman, Andrew N Redington, Elaine M Urbina
Journal: Circulation (2016)

Introduction: Vascular dysfunction is associated with diminished functional capacity and quality of life in adolescent and young adult Fontan survivors. Patient and procedural factors associated with diminished endothelial and autonomic function have not been established. Methods: Cross-sectional single-institution study of Fontan survivors ages 8-25 years. Anthropometric characteristics were obtained. Endothelial function was assessed with brachial flow mediated dilation (FMD) and peripheral arterial tonometry reactive hyperemia index (lnRHI; EndoPAT). Autonomic function was assessed by heart rate variability (HRV; SphygmoCor). Records were reviewed for anatomic, hemodynamic and surgical characteristics, which served as predictor variables while vascular measures served as outcome variables. Bivariate predictors (p&lt;0.1) were candidates for inclusion in multivariable models. Model development utilized linear regression techniques. Results: Sixty patients (52% male, 90% Caucasian) completed the protocol with a mean age of 13.9 ± 4.1 years and duration of Fontan circulation of 9.9 ± 4.2 years. Median weight was 43.5 (IQR 31.4, 58.3) kg and BMI was 18.7 (16.1, 22.6) kg/m 2 . A single left ventricle was present in 65%. Mean FMD was 10.2 ± 5.5% and lnRHI was 0.236 ± 0.398. Median HRV was 41.2 (29.4, 52.0) ms. Major determinants of FMD included height, total # of surgeries and stage I palliation length of stay (LOS) (R 2 0.29, p&lt;0.001), whereas determinants of lnRHI included prior Norwood procedure, systolic blood pressure, resting heart rate and oxygen saturation (SaO 2 ), mixed venous SaO 2 and cardiac index (CI) at pre-Fontan catheterization (cath) and total # of hospitalizations (R 2 0.27, p=0.01). Major determinants of HRV included total duration of surgical circulatory arrest, CI at pre-Fontan cath and Fontan completion LOS (R 2 0.39, p=0.006). Traditional cardiovascular risk factors including weight and BMI were not independent determinants. Conclusions: Multiple patient and procedural factors are associated with diminished endothelial and autonomic function in adolescent and young adult Fontan survivors. Targeted intervention of modifiable risk factors may improve long-term vascular health and functional status.
Low-Fat vs Low-Carbohydrate Diets and Weight Loss
Authors: Lu Qi, George A. Bray, Frank M. Sacks
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Brain proton magnetic resonance spectroscopy (1H-MRS) in Alzheimer's disease: changes after treatment with xanomeline, an M1 selective cholinergic agonist
Authors: A Satlin, N Bodick, W W Offen, P F Renshaw
Journal: American Journal of Psychiatry (1997)

Higher than normal cellular levels of the phospholipid catabolic intermediate glycerophosphocholine have been found in postmortem brain tissue of persons with Alzheimer's disease. Proton magnetic resonance spectroscopy (1H-MRS) can detect a choline resonance that is largely due to glycerophosphocholine. The authors tested the hypothesis that treatment with xanomeline, an M1 selective muscarinic cholinergic agonist, would be associated with a decrease in the 1H-MRS choline resonance.Patients with mild to moderate Alzheimer's disease received placebo or xanomeline for 6 months. 1H-MRS spectra were collected at baseline and after treatment discontinuation for 12 patients, two taking placebo and 10 taking xanomeline at a dose of 25 mg t.i.d. (N = 4), 50 mg t.i.d. (N = 3), or 75 mg t.i.d. (N = 3).For the combined group of patients taking xanomeline, there was a significant decrease in the choline/creatine ratio from baseline to endpoint.Treatment of Alzheimer's disease with a cholinergic agonist is associated with a decrease in the MRS choline resonance. Xanomeline may reduce breakdown of cholinergic neuron membranes by reducing the cellular requirement for free choline for acetylcholine synthesis.
Tratamiento de la oclusión colónica mediante uso de prótesis colónica
Authors: AA Maynard, CE Ramirez Salazar De Vela, M Masachs Peracaula, M Abu-Suboh Abadia, J Armengol Bertoli, A Benages Curell, MD Castillo Cejas, J Guevara Cubas, M Pigrau Pastor, D Sihuay Diburga, J Dot Bach, JR Armengol Miro
Journal: Endoscopy (2017)

Las prótesis metálicas autoexpandibles constituyen una alternativa terapéutica en el manejo de la oclusión colónica. Su indicación más frecuente es paliativa o como puente terapéutico a la cirugía. También son utilizadas para la compresión extrínseca o metastásica de otras etiologías.
The Treatment of Thrombophlebitis
Authors: Irving S. Wright
Journal: JAMA (1963)

INFLAMMATION in and around a vein in which there is clot formation is known as thrombophlebitis. When the inflammation primarily involves the outer walls of the vein without the development of thrombosis, we term this condition "periphlebitis." Usually, after a short time, a clot does form and the diagnosis then is thrombophlebitis. However, if a clot forms first due to stasis, as in a postoperative condition, and little or no inflammation of the wall occurs, the condition may be termed phlebothrombosis during the early phase. Usually, as time passes, the venous wall will be involved and thus the diagnosis is thrombophlebitis. It is often difficult to determine the exact stage of development by clinical observation alone. In fact, several stages of this process may be present simultaneously, and, at present, our feeling is that the treatment should be essentially the same. <h3>Classification and Etiology</h3> There are many causes of
Perceptual theories that emphasize action are necessary but not sufficient
Authors: John R. Pani
Journal: Behavioral and Brain Sciences (2001)

Theories that make action central to perception are plausible, though largely untried, for space perception. However, explaining object recognition, and high-level perception generally, will require reference to representations of the world in some form. Nonetheless, action is central to cognition, and explaining high-level perception will be aided by integrating an understanding of action with other aspects of perception.
Abstract 16640: Conductive Biomaterial Enhanced Electrical Propagation Across a Left Ventricular Scar After a Myocardial Infarction
Authors: Sheng He, Jun Wu, Wenjuan Yin, Zhengbo Shao, Richard D Weisel, Ren-Ke Li
Journal: Circulation (2016)

Introduction: After an MI, hydrogels such as chitosan have been used clinically to stabilize the LV free wall and prevent dilation. We chemically modified chitosan with the charge-carrying conducti...
Ablación con radiofrecuencia guiada por ecoendoscopia de quistes mucinosos y tumores neuroendocrinos pancreáticos: Un estudio piloto
Authors: C De La Serna Higuera, ST Law, B Madrigal, M Cimavilla, R Torres, H Núñez, P Diez, P Gil, M Pérez-Miranda
Journal: Endoscopy (2017)

La ablación por radiofrecuencia guiada mediante ecoendoscopia (ARF-EE) constituye una alternativa mínimamente invasiva en pacientes con tumores pancreáticos no candidatos a cirugía. Existen publicados casos aislados de ARF-EE con buena respuesta. Sin embargo se desconoce eficacia y seguridad real y tipos de lesiones tratables mediante esta técnica.
¿Mejora un menú específico sin residuos la limpieza de 4 L de PEG no fraccionados en las colonoscopias de primera mitad de la mañana?
Authors: JM Pérez Pozo, F Martínez-Alcalá García, D Martínez Mendoza, J Oliva Contero
Journal: Endoscopy (2017)

En ocasiones, los pacientes, no realizan de forma adecuada la dieta pobre en residuos previa a la colonoscopia. Por otro lado, fraccionar la preparación de 4 l de PEG en las colonoscopias realizadas con sedación de la primera mitad de la mañana resulta difícil, al precisar tomar la última dosis de madrugada.
Abstract 17614: Genome-Wide Association Study of Aspirin Responsiveness in African Americans
Authors: Rehan Qayyum, Diane M Becker, Lisa R Yanek, Nauder Faraday, Bhoom Suktitipat, Rasika Mathias, Lewis C Becker
Journal: Circulation (2011)

While familial studies have established that inter-individual variability in platelet response to aspirin (ASA) is partly due to genetic variation, a genome-wide association study (GWAS) has not been reported in African Americans. Fasting blood samples were obtained from healthy African Americans (N=868) with family history of premature coronary artery disease. Optical aggregation was measured in platelet-rich plasma (PRP) after samples were stimulated with collagen (1, 2, 5 µg/mL), ADP (2, 10 µmol/L), or epinephrine (2, 10 µmol/L) before and after 14-days of ASA therapy. A cohort of European ancestry (N=1236) provided replication. In each cohort, age- and sex-adjusted linear mixed effects models adjusting for family structure were used to test for association between each SNP and each phenotype under an additive model. We analyzed data with adjustment for pre-ASA platelet studies to examine the pure effect of ASA and without adjustment which is likely to be closer to the clinically observed effect. We sought region-based replication with adjustment for the number of LD blocks in HapMap CEU population. We observed SNPs in 3 regions (2 intronic and 1 intergenic) that crossed GWAS threshold of significance (p&lt;5 x 10 -8 ). A SNP in the PEAR1 gene, rs12041331, was significantly associated with most doses of the three agonists and this association remained significant after adjusting for pre-ASA platelet studies (Table). In the replication cohort, rs12041331 was also nominally significant. SNPs close to the other two GWAS-significant SNPs were nominally significant in the replication cohort after adjusting for the LD structure. In this first GWAS of platelet response to ASA therapy in African Americans, we show a relationship between post-ASA platelet reactivity and 3 regions, and replicate these findings in an independent sample. Both PEAR1 and CRB1 are expressed in platelets and are good candidates for follow-up studies examining ASA responsiveness.
ENDOSCOPIC TREATMENT OF PATIENTS WITH HIGH-RISK EARLY ESOPHAGEAL CANCER
Authors: M Kollar, J Krajciova, J Maluskova, A Pazdro, T Harustiak, D Kodetova, Z Vackova, J Spicak, J Martinek
Journal: Endoscopy (2018)

The aim of this study was to assess outcomes of endoscopic treatment in patients with 'high-risk' early esophageal cancer (EEC). 'High-risk' cancer was defined as any cancer with sm invasion or mucosal cancer with at least one of the following: poor differentiation, invasion to blood or lymphatic vessels and high tumor cell dissociation. The main outcome measurement was tumor-free survival.
Management of Relapsed and Refractory Hodgkin Lymphoma in 2018
Authors: Sarah C. Rutherford, John P. Leonard
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Prophylactic angiographic embolisation in high-risk peptic ulcer bleeding after achieved endoscopic control: maximising outcomes
Authors: Romaric Loffroy, Marc Bardou
Journal: Gut (2018)

We read with great interest the article by Lau et al recently published in Gut and evaluating the role of prophylactic angiographic arterial embolisation performed after achieved endoscopic haemostasis in the management of patients with high-risk ulcer bleeding.1 We have several comments. First of all, we would like to congratulate the authors for their study which represents the largest multicentre randomised controlled trial to date reporting results of additional embolisation in selected high-risk patients with peptic ulcer bleeding. The authors’ hypothesis was that added angiographic embolisation performed within 12 hours from successful endoscopic therapy may reduce the rate of rebleeding in patients with bleeding from high-risk peptic ulcers. Unfortunately, the authors failed to demonstrate any statistically significant impact of added …
EXAMINATION OF THE EFFICACY OF THE CAPSULE ENDOSCOPY IN ELDERLY PEOPLE
Authors: S Kurokawa, T Suwa, Y Makiguchi, F Hata, T Yajima
Journal: Endoscopy (2018)

Increases the search of gastrointestinal disease in the elderly, the need for the search of the small intestine disease is increasing. In the elderly, using small bowel capsule endoscopy (CE), it was to evaluate the efficacy.
Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia
Authors: Chelsea L. Dieck, Gannie Tzoneva, Farhad Forouhar, Zachary Carpenter, Alberto Ambesi-Impiombato, Marta Sánchez-Martín, Renate Kirschner-Schwabe, Scott Lew, Jayaraman Seetharaman, Liang Tong, Adolfo A. Ferrando
Journal: Cancer Cell (2018)
Oral Sodium Sensor for Hypertension Management
Authors: Jennifer Abbasi
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EUS-GUIDED DRAINAGE OF PERIPANCREATIC FLUID COLLECTIONS WITH LUMEN-APPOSING METAL STENTS: PRELIMINARY RESULTS OF A PROSPECTIVE MULTICENTER STUDY IN GREECE
Authors: AD Sioulas, I Karoumpalis, D Kypraios, I Scotiniotis, G Vlachonikolou, K Rosiou, A Vezakis, D Xynopoulos, K Triantafyllou, A Polydorou, IS Papanikolaou
Journal: Endoscopy (2018)

Endoscopic ultrasound (EUS)-guided transmural drainage using lumen-apposing metal stents (LAMSs) is a promising approach for symptomatic peripancreatic fluid collections (PFCs). We aim to assess their use in terms of technical success, clinical success and adverse events (AEs).
Prevención mediante clips hemostáticos de la hemorragia post-polipectomía en colonoscopias de cribado de cáncer de colon y recto
Authors: J García-Cano Lizcano, M Suárez Matías, M Muñiz Muñoz, C Murillo Matamoros, M Viñuelas Chicano, M Del Moral, L Valiente González, T Martínez Pérez, R Martínez Fernández, CJ Gómez Ruiz
Journal: Endoscopy (2017)

La hemorragia post-polipectomía es la complicación más frecuente de la polipectomía colónica. El sangrado diferido conlleva un gasto considerable en recursos, además de las molestias ocasionadas a pacientes y sus familiares. Se han descrito varios métodos para prevenir el sangrado diferido. El uso profiláctico de hemoclips parece reducir el riesgo de sangrado.
Good cop, bad cop: anaerobes in cystic fibrosis airways
Authors: Lindsay J. Caverly, John J. LiPuma
Journal: European Respiratory Journal (2018)

<b>The role(s) that anaerobic bacterial species play in the complex microbial communities inhabiting the airways of people with cystic fibrosis has been the subject of several recent investigations. These studies have demonstrated seemingly conflicting results.</b>http://ow.ly/Qom630kB9DG
Effect of oral fluticasone on refractory peptic esophageal stricture – a new therapeutic method
Authors: A. Cai, S. Yarandi, R. Kung, J. Brown, H. Xu, Q. Cai
Journal: Endoscopy (2014)

Correction to: Effect of oral fluticasone on refractory peptic esophageal stricture – a new therapeutic methodEndoscopy 2012; 44(S 02): E408-E409DOI: 10.1055/s-0032-1310257
Microbiota‐Dependent Involvement of Th17 Cells in Murine Models of Inflammatory Arthritis
Authors: Heather Evans‐Marin, Rebecca Rogier, Sergei B. Koralov, Julia Manasson, Debbie Roeleveld, Peter M. van der Kraan, Jose U. Scher, Marije I. Koenders, Shahla Abdollahi‐Roodsaz
Journal: Arthritis & Rheumatology (2018)

Intestinal microbiota are associated with the development of inflammatory arthritis. The aim of this study was to dissect intestinal mucosal immune responses in the preclinical phase of arthritis and determine whether the presence of Th17 cells, beyond involvement of the cytokine interleukin-17 (IL-17), is required for arthritis development, and whether the involvement of Th17 cells in arthritis depends on the composition of the host microbiota.Mucosal T cell production of IL-17, interferon-γ, tumor necrosis factor α (TNFα), IL-22, and granulocyte-macrophage colony-stimulating factor (GM-CSF) was analyzed by flow cytometry and Luminex assay before arthritis onset in mice immunized to develop collagen-induced arthritis (CIA). Pathogenic features of arthritis in mice with CIA and mice with antigen-induced arthritis were compared between Th17 cell-deficient (CD4-Cre+ Rorcflox/flox ) and Th17 cell-sufficient (CD4-Cre- Rorcflox/flox ) mice. In addition, the impact of intestinal microbiota on the Th17 cell dependence of CIA was assessed.Lamina propria CD4 T cells were activated before the onset of arthritis in mice with CIA, with marked up-regulation of several cytokines, including IL-17A, TNFα, and GM-CSF. CD4-Cre+ Rorcflox/flox mice showed a specific reduction in intestinal mucosal levels of Th17 cells and partially reduced levels of IL-17-producing CD8 T cells. However, total levels of IL-17A, mostly produced by γδ T cells and neutrophils, were unaffected. The severity of arthritis was significantly reduced in Th17 cell-deficient mice, suggesting that Th17 cells have additional, IL-17A-independent roles in inflammatory arthritis. Accordingly, antigen-stimulated T cells from Th17 cell-deficient mice produced less IL-17A, IL-17F, and GM-CSF. Importantly, the dependence of CIA on the involvement of Th17 cells was mitigated in the presence of an alternative microbiome.These data from murine models suggest that activation of mucosal immunity precedes the development of arthritis, and also that Th17 cells have a microbiota-dependent role in arthritis. Therefore, a microbiome-guided stratification of patients might improve the efficacy of Th17-targeted therapies.
Fourteen new specialist treatments get routine NHS funding
Authors: Jacqui Wise
Journal: BMJ (2018)

NHS England has approved routine funding for 14 new specialised treatments, including a heart implant to reduce risk of stroke, a surgical procedure that will improve the mobility of children with cerebral palsy, and drugs for cancer, haemophilia, osteoporosis, and familial hypercholesterolaemia.1

The treatments were assessed by the Clinical Priorities Advisory Group, chaired by Nick Partridge and made up of doctors, specialists, and patients’ representatives. The group assesses drugs, medical devices, and treatments according to their clinical effectiveness, benefit to patients, and value for money. It considers recommendations from clinical reference groups and teams covering specialised commissioning responsibilities.

The group has approved funding for left atrial appendage occlusion, which is an alternative treatment for patients with atrial fibrillation who cannot take an oral anticoagulant. It …
Cough and Bronchial Responsiveness in Firefighters at the World Trade Center Site
Authors: John H Lange
Journal: New England Journal of Medicine (2003)

to the editor: Prezant and colleagues (Sept. 12 issue) 1 describe cough and bronchial responsiveness in firefighters at the World Trade Center. They attribute the observed sinusitis, bronchial hyperreactivity, and bronchial responsiveness to dust inhalation. Although the dust had settled after six days, the peak incidence of disability occurred in late October and early November. This points to an illness with two phases, with World Trade Center cough representing a late-phase reaction. If this is to be an adequate explanation, we must account for sinusitis, bronchial hyperreactivity, and bronchial responsiveness among healthy firefighters exposed to the dust from the collapsed buildings. Aspergillus is known to cause allergic bronchopulmonary aspergillosis and allergic sinusitis. A well-known risk factor is building demolition. 2
Implementación de la disección submucosa endoscopica con sistema de hidrodisección ERBEJET® y endobisturí HybridKnife: Serie de 189 casos
Authors: F Ramos-Zabala, A Domínguez-Pino, L Moreno-Almazán, FJ Pérez-Rodríguez, J Rodríguez-Pascual, A Alzina-Pérez, M García-Mayor, J Vásquez-Guerrero, C Gil-Páez, E Gento-Peña
Journal: Endoscopy (2017)

La disección submucosa endoscópica (DSE) es difícil de implantar en Occidente debido a la larga curva de aprendizaje y al riesgo de complicación. En la mayoría de los centros europeos se utiliza el mismo material que desarrollaron los expertos japoneses creadores de la técnica. El sistema de hidrodisección ERBEJET®, desarrollado en Europa, no es un procedimiento validado en Japón.