tbuckley/cabot-search huggingface dataset:
Reply to Sasso <i>et al.</i>: Are All Steps Created Equal? Revisiting Pedometer Use during Pulmonary Rehabilitation for Individuals Living with Chronic Obstructive Pulmonary Disease
Authors: Claire M. Nolan, Matthew Maddocks, Jane L. Canavan, Sarah E. Jones, Veronica Delogu, Djeya Kaliaraju, Winston Banya, Samantha S. C. Kon, Michael I. Polkey, William D.-C. Man
Journal: American Journal of Respiratory and Critical Care Medicine (2017)
THE FRONTAL PLANE KNEE PROJECTION ANGLE IN ELITE MALE VOLLEYBALL ATHLETES IS INCREASED AFTER AN INCREMENTAL SHUTTLE RUN TEST UNTIL VOLUNTARY FATIGUE
Authors: Luciana Mendonça, Bittencourt Natália, Silva Davidson, Prado Luciano
Journal: British Journal of Sports Medicine (2017)

Background Knee valgus is associated with non-contact anterior cruciate ligament rupture and this injury commonly occurs at the end of competition and/or training sessions. Probably, muscle fatigue is associated to this injury occurrence. Clinically, knee valgus is easily identified by the quantification of frontal plane knee projection angle (FPKPA). Objective The purpose of this study was to compare FPKPA before and after a maximal, incremental shuttle-run testing protocol used to induce fatigue in elite male volleyball athletes. Design Cross-sectional study. Setting Sports Sciences Laboratory at the Universidade Federal de Minas Gerais. Patients (or Participants) Thirteen elite male volleyball athletes with a mean age of 27.69 (+7.85) years, body mass of 92.00 (+8.97) kilograms and height of 1.94 (0.06) meters participated in a preseason assessment. Interventions (or Assessment of Risk Factors) Fatigue was induced by performing a maximal-incremental shuttle-run test for the estimation of maximal aerobic power according to the protocol proposed by Ramsbotton et al . (1988). Main Outcome Measurements FPKPA was measured during single-leg squat and involved a line connecting antero-superior iliac spine, a middle point between knee condyles and a middle point between the malleolus. The athletes performed 3 single-leg squats and a mean of the 3 FPKPA on the dominant lower limb was analyzed. Results The dominant lower limb had a mean FPKPA of 3,18 o (±4.23) prior to and a mean FPKPA of 3.73 o (±4.03) after the fatigue protocol. A Studen's t-test analysis showed a statistical significant difference (p=0.019; mean difference=3.18; IC 95% of 0.62–5.74). Conclusions Elite male volleyball athletes had higher values of FPKPA on the dominant lower limb after a maximal, progressive exercise leading to fatigue. Probably, elite volleyball players may be under a higher risk of muscle-skeletal injuries under muscle fatigue conditions.
Brain volume reduction after whole-brain radiotherapy: quantification and prognostic relevance
Authors: Christian Hoffmann, Luitpold Distel, Stefan Knippen, Thomas Gryc, Manuel Alexander Schmidt, Rainer Fietkau, Florian Putz
Journal: Neuro-Oncology (2017)

Recent studies have questioned the value of adding whole-brain radiotherapy (WBRT) to stereotactic radiosurgery (SRS) for brain metastasis treatment. Neurotoxicity, including radiation-induced brain volume reduction, could be one reason why not all patients benefit from the addition of WBRT. In this study, we quantified brain volume reduction after WBRT and assessed its prognostic significance. Brain volumes of 91 patients with cerebral metastases were measured during a 150-day period after commencing WBRT and were compared with their pretreatment volumes. The average daily relative change in brain volume of each patient, referred to as the "brain volume reduction rate," was calculated. Univariate and multivariate Cox regression analyses were performed to assess the prognostic significance of the brain volume reduction rate, as well as of 3 treatment-related and 9 pretreatment factors. A one-way analysis of variance was used to compare the brain volume reduction rate across recursive partitioning analysis (RPA) classes. On multivariate Cox regression analysis, the brain volume reduction rate was a significant predictor of overall survival after WBRT (P < 0.001), as well as the number of brain metastases (P = 0.002) and age (P = 0.008). Patients with a relatively favorable prognosis (RPA classes 1 and 2) experienced significantly less brain volume decrease after WBRT than patients with a poor prognosis (RPA class 3) (P = 0.001). There was no significant correlation between delivered radiation dose and brain volume reduction rate (P = 0.147). In this retrospective study, a smaller decrease in brain volume after WBRT was an independent predictor of longer overall survival.
02.03 Influence of free fatty acids on osteoblasts and osteoclasts in rheumatic diseases
Authors: Klaus Frommer, Andreas Schäffler, Uwe Lange, Stefan Rehart, Jürgen Steinmeyer, Markus Rickert, Ulf Müller-Ladner, Elena Neumann
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Increased amounts of visceral fat are often associated with lower bone density. Also, in obese patients an increased risk of osteoarthritis can be seen in non-weight bearing joints. Chronically elevated free fatty acid (FFA) levels as occurring in obesity may therefore also play a role in bone loss. We hence analysed if and how FFA influence cells of bone metabolism in rheumatic diseases. <h3>Methods</h3> Primary osteoblasts (OB) were isolated from cancellous bone of OA and RA patients undergoing knee joint surgery. Osteoclasts (OC) were differentiated from peripheral blood mononuclear cells (PBMC). OB and OC were stimulated with the saturated FFA palmitic acid (PA) and the unsaturated FFA linoleic acid (LA). Protein secretion was quantified by immunoassays, mRNA expression by real-time PCR. Mineralization activity was quantified using Alizarin Red S staining, differentiated OC were quantified by counting TRAP-positive multinuclear cells. Toll-like receptor (TLR) 4 and TLR2 were blocked by neutralising antibodies. <h3>Results</h3> Stimulation with PA or LA increased OB secretion of the proinflammatory cytokine IL6 (up to 9-fold ↑) and the chemokines IL-8 (up to 221-fold ↑), GRO-α (from below detection level to detectable levels) and MCP1 (up to 16-fold ↑). RANKL and OPG were not influenced by FFA on protein and mRNA level. In osteoblasts, activity (ALP/collagen type I) and differentiation markers (e.g. osteocalcin) as well as production of inorganic matrix were not altered by FFA stimulation. TLR4 but not TLR2 blockade significantly reduced PA-induced IL-8 secretion by OB. Secretion of IL-8 by RA OC was increased by FFA, while MMP-9 was reduced. The mRNA expression of osteoclast activity markers (CLCN7, CTSK, TCIRG) remained unchanged. However, the number of TRAP positive multinuclear cells formed from RA PBMC was decreased (by around 50%). <h3>Conclusions</h3> The pro-inflammatory effect of certain FFA on osteoblasts and osteoclasts may indirectly contribute to bone loss, while the reduction of mature OC after FFA stimulation suggests an inhibitory effect on bone resorption. In osteoblasts, FFA signalling is at least in part mediated by TLR4, but not by TLR2.
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors
Authors: Jiazhi Sun, De-An Wang, Rishi Jain, Steve Paquette, Eileen Ennis, Michelle Blaskovich, Laura Baldini, Domenico Coppola, Andrew D. Hamilton, Said M. Sebti
Journal: Cancer Research (2004)

4533   Angiogenesis is a complex process that depends on several growth factors including those such as VEGF that are involved in initiation of the formation of new blood vessels and those such as PDGF that are involved in vessel maintainence. Therefore, interfering with both processes may be necessary for efficient inhibition of angiogenesis and tumor growth. We designed GFB-204 a synthetic molecule that potently blocks binding of PDGF and VEGF to their receptors (200-500nM) and subsequently inhibits PDGFR and Flk-1 tyrosine phosphorylation and stimulation of the mitogen-activated kinases Erk1/2. GFB-204 is selective for PDGF and VEGF and does not inhibit EGF, IGF-1 and FGF-stimulation of Erk1/2. GFB-204 inhibits human endothelial cell migration and capillary network formation in vitro and angiogenesis in vivo. Finally, treatment of mice with GFB-204 suppresses human tumor growth and angiogenesis in nude mouse xenografts. These studies have far-reaching implications for the treatment of cancer.
Declining Clinical Course of Psychotic Disorders Over the Two Decades Following First Hospitalization: Evidence From the Suffolk County Mental Health Project
Authors: Roman Kotov, Laura Fochtmann, Kaiqiao Li, Marsha Tanenberg-Karant, Eduardo A. Constantino, Joan Rubinstein, Greg Perlman, Eva Velthorst, Anne-Kathrin J. Fett, Gabrielle Carlson, Evelyn J. Bromet
Journal: American Journal of Psychiatry (2017)

Kraepelin considered declining course a hallmark of schizophrenia, but others have suggested that outcomes usually stabilize or improve after treatment initiation. The authors investigated this question in an epidemiologically defined cohort with psychotic disorders followed for 20 years after first hospitalization.
Despite Increasing Size of Unrelated Donor (URD) Registries and the Global Cord Blood (CB) Inventory Racial Disparities in Access to URD and CB Grafts Persist: A Prospective 10 Year Analysis of 1,112 Patients
Authors: Kirsten Boughan, Parastoo B. Dahi, Sean Devlin, Courtney Byam, Yeon Yoo, Christopher Mazis, Eric Davis, Melissa Nhaissi, Jennifer Paulson, Deborah Wells, Candice Cooper, Doris M Ponce, Sergio Giralt, Esperanza B. Papadopoulos, Nancy A. Kernan, Andromachi Scaradavou, Juliet N. Barker
Journal: Blood (2016)
18F-FDG PET/CT of Secondary Epithelioid Angiosarcoma of the Proximal Femur in a Patient With Polyostotic Fibrous Dysplasia
Authors: Michiyuki Hakozaki, Hitoshi Yamada, Osamu Hasegawa, Kazuo Watanabe, Shinichi Konno
Journal: Clinical Nuclear Medicine (2017)

Fibrous dysplasia rarely transforms into a secondary malignancy. We present the PET/CT findings at pretreatment and posttreatment in an exceedingly rare case of epithelioid angiosarcoma of the bone secondary to polyostotic fibrous dysplasia.
THREE-DIMENSIONAL ANALYSIS OF SCAPULAR KINEMATICS DURING ARM ELEVATION IN BASEBALL PLAYERS WITH SCAPULAR DYSKINESIS: COMPARISON OF DOMINANT AND NON-DOMINANT ARMS
Authors: Ho-Dong Yu, Jin-Young Park
Journal: British Journal of Sports Medicine (2017)

Background The knowledge of 3-dimensional (3D) scapular kinematics is essential for understanding the pathological lesions of shoulder and elbow in throwing athletes. To date, a number of studies about alterations of static scapular position, dynamic scapular motion, or scapular dyskinesis have been conducted, yet none of them have identified consistent pattern of altered scapular kinematics in throwing athletes. Ojective To analyze the 3D scapular kinematics of dominant and non-dominant arms in baseball players with a pathological condition of shoulder or elbow. Design Cross-Sectional Study. Setting Baseball players from middle school to professional players. Patients (or Participants) 319 baseball players who visited our clinic with the pathological condition of shoulder or elbow from December 2011 to August 2015. Interventions (or Assessment of Risk Factors) The CT scan was performed using a 64-channel multidetector CT system in a prone position with the arms at the side of the body and at 150° forward elevation with the palms toward the body. Main Outcome Measurements From 3D computed tomography, angular values of the scapula were compared between dominant and non-dominant arms with statistical analysis. Results The scapular position of dominant arms showed significantly more AT, less ST at rest and more UR, IR and less ST, PRO, AT at 150° full FE compared to the non-dominant arms. The angular increment of scapular UR, IR, PRO, and AT during arm elevation increased significantly between the paired arms. Conclusions When compared to the non-dominant arms, UR, AT and PRO with the arm at 150° FE of dominant symptomatic arms in baseball players tilted towards positive compensation while IR altered towards negative decompensation. In addition, the motion of the scapula increases significantly in dominant symptomatic arms, compared to the non-dominant arms.
NCI mpact: National Cancer Institute molecular profiling-based assignment of cancer therapy.
Authors: Shivaani Kummar, Mickey Williams, Chih-Jian Lih, Alice P. Chen, Larry Rubinstein, Ramya Antony, Eric Polley, Yingdong Zhao, Barbara A. Conley, Richard Simon, James H. Doroshow
Journal: Journal of Clinical Oncology (2014)

TPS2642 Background: There is growing interest in matching targeted agents to genetic aberrations found in tumors of patients in early phase trials. MPACT is a randomized trial designed to assess whether response rate (CR+PR) and progression-free survival (PFS) are improved following treatment with agents chosen based on the presence of specific mutations in patient tumors compared to treatment regimens assigned from the complementary set not prospectively identified to target one of their mutations. Methods: Eligible adult patients have refractory solid tumors that had progressed following at least one line of standard therapy (std) and/or for which no std has been shown to improve survival. Patients are required to undergo tumor biopsy, which will be sequenced in a CLIA-certified lab for the presence of specific actionable mutations of interest (aMOIs) in 20 genes belonging to 3 pathways: DNA repair, PI3K, and RAS/RAF (total of 391 aMOIs). Patients in whom an aMOI is detected will be randomized 2:1 into Arms A or B using a rules-based, locked algorithm: Arm A will receive an agent prospectively identified to target that mutation/pathway; Arm B will receive an agent from the complementary set (not prospectively identified to target one of their mutations). Patients in Arm B will be allowed to cross over at time of disease progression to a treatment regimen based on their mutational analysis. Targeted drugs are administered at recommended Phase 2 doses and schedules: ABT-888 (PARP inhibitor) with temozolomide, or MK-1775 (Wee1 inhibitor) plus carboplatin for defects in the DNA repair pathway; everolimus (mTOR inhibitor) for mutations in the PI3K pathway; trametinib DMSO (MEK inhibitor) for mutations in the RAS pathway. A total of 180 evaluable patients will be randomized; the comparison of response rates will have 88% power to detect an overall difference of 20% vs. 5% objective response, conducted at the 1-sided, 0.04 significance level. The comparison of PFS will have 90% power to detect an increase of 80% in median PFS, conducted at the 1-sided, 0.01 significance level. The trial is currently open and accruing at the NIH Clinical Center in Bethesda, Maryland. Clinical trial information: NCT01827384.
Note on Benzoylarginineamidase Activity in Extracts of Rat Liver and Hepatoma
Authors: Jesse P. Greenstein, Florence M. Leuthardt
Journal: JNCI Journal of the National Cancer Institute (1947)

Note on Benzoylarginineamidase Activity in Extracts of Rat Liver and Hepatoma Get access Jesse P. Greenstein, Jesse P. Greenstein chief biochemist Search for other works by this author on: Oxford Academic PubMed Google Scholar Florence M. Leuthardt Florence M. Leuthardt junior biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 8, Issue 2, October 1947, Pages 77–78, https://doi.org/10.1093/jnci/8.2.77 Published: 01 October 1947 Article history Published: 01 October 1947 Received: 06 October 1947
コア‐多シェルナノキャリア:軟X線顕微分光法により調査したデキサメタゾンの輸送と放出
Authors: K Yamamoto, A Klossek, R Flesch, T Ohigashi, E Fleige, F Rancan, J Frombach, A Vogt, U Blume-Peytavi, P Schrade, S Bachmann, R Haag, S Hedtrich, M Schaefer-Korting, N Kosugi, E Ruehl
Journal: Journal of Controlled Release (2016)
01.13 Igf1R signalling contributes to T cell dependent inflammation in rheumatoid arthritis
Authors: Malin C Erlandsson, Sofia Töyrä Silfverswärd, Mitra Nadali, Mattias ND Svensson, Ing-Marie Jonsson, Karin ME Andersson, Maria I Bokarewa
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Signalling through insulin-like growth factor (IGF) 1 receptor is essential for cell survival, but may turn pathogenic in uncontrolled tissue growth in tumours. In rheumatoid arthritis (RA), the IGF-1R signalling is activated supporting expansion of the inflamed synovia. <b>The aim</b> of the present study was to understand the place of IGF-1R expression and signalling for development of adaptive immune responses in the setting of prospective RA cohort and in experimental arthritis. <h3>Material and methods</h3> Clinical associations of IGF1R expression in leukocytes of the peripheral blood were studied in 84 female RA patients with mean disease duration 8 years, all treated with methotrexate at the time of enrolment. Consequences of the IGF1R signalling inhibition for arthritis were studied in mBSA immunised Balb/c mice treated with NT157 compound promoting degradation of IRS-1/2. <h3>Results</h3> In RA patients, high expression of IGF1R in leukocytes was associated with and systemic inflammation as verified by higher transcription factor NF-kB, serum levels of IL-6 and erythrocyte sedimentation rate, and higher pain perception. Additionally, phosphorylated IGF1R and STAT3 enriched T cells infiltrate in RA synovia. Treatment with NT157 inhibited the phosphorylation of IGF1R and STAT3 in synovia, and alleviated arthritis and erosions in mice. It also reduced expression of IGF1R in spleen T cells and despaired ERK and Akt signalling. This limited the ability of mBSA-specific T cells to produce IL-6, IFNg and IL-17. The reduction of IL-6 and IL-17 levels was associated with changed RoRgt/FoxP3 balance. <h3>Conclusion</h3> IGF1R signalling contributes to T cell dependent inflammation in arthritis. Inhibition of IGF1R signalling alleviates arthritis by restricting IL-6 dependent formation of Th17 cells and may open for new treatment strategies in RA.
Inflammatory features of infrapatellar fat pad in rheumatoid arthritis versus osteoarthritis reveal mostly qualitative differences
Authors: Anja Jacoba de Jong, Inge R. Klein-Wieringa, Joanneke C Kwekkeboom, René E.M. Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay
Journal: Annals of the Rheumatic Diseases (2017)

Rheumatoid arthritis (RA) and osteoarthritis (OA) are characterised by joint destruction. In both diseases, inflammation is implicated; however, RA is generally associated with more inflammation in synovium1 and synovial fluid (SF)2–4 compared with OA. The infrapatellar fat pad (IFP), an adipose tissue located in the knee joint, has been proposed to contribute to disease progression in OA. Although IFP of OA has been extensively characterised and identified as a source of inflammation in the joint,5–7 only scarce information is available on IFP in patients with RA. Therefore, our aim was to get a first insight into the possible contribution of IFP to the inflammatory processes in the RA joint.

To this end, we compared leftover IFP and synovium from patients with RA (n=20: 80% women, mean (SD) age 64 (10.7) years, median (range) body mass index (BMI) 26.9 (18) kg/m2) and patients with primary knee OA (n=51: 62% women, mean (SD) age 66 (8.9) years, median (range) BMI 28.9 (15) kg/m2); all were undergoing knee joint replacement surgery. The study was approved by the local medical ethical committee. Fat-conditioned medium (FCM) and adipocyte-conditioned medium (ACM) were generated as previously described.5 Adipokines and cytokines were measured in FCM …
グリオーマに対する相乗化学療法/放射線療法を促進するためのドキソルビシンキャリアとしての低酸素誘発および低酸素高めたリポソームの開発【Powered by NICT】
Authors: Liu Hongmei, Xie Yandong, Zhang Yafei, Cai Yifan, Li Baiyang, Mao Honglin, Liu Yingguo, Lu Jun, Zhang Longzhen, Yu Rutong
Journal: Biomaterials (2017)
Development of mimotopes of tumor-associated antigens and their use in a novel immunosensor to detect differential circulating antibodies in patients with prostate cancer and benign prostatic hyperplasia.
Authors: Luiz Goulart, Ana Paula Freschi, Adriana Neves, Juliana Almeida, Fausto Capparelli, Carlos Prudencio, Guilherme Souza, Rone Cardoso, Danielo Freitas
Journal: Cancer Research (2007)

4315   Actually, the prostate specific antigen (PSA) is the only useful molecule to detect prostatic diseases, but with very low specificity for prostate cancer diagnostics. Therefore, the identification of new antigens associated with prostate cancer may provide new biomarkers and novel tools for the development of specific diagnostics and treatment modalities. This investigation aimed the identification of recombinant peptides in phage display libraries that are able to discriminate prostate cancer (PCa) from benign prostatic hyperplasia (BPH). Specific pathogen-free chickens were immunized with total proteins of tumor prostatic tissues, and produced specific IgY that were purified by HyTrap chromatographic columns and later used for peptides’ selection. Twenty-nine specific peptides were generated among 480 clones sequenced. The selected clones were further characterized through bioinformatics with subsequent dot-immunoblotting and ELISA assays in order to verify their reactivity and specificity. We were able to identify biological targets that were differently expressed in sera of patients with benign prostatic hyperplasia or prostate cancer. Among the 29 peptides, twenty-three clones presented specific reactivity with patients’ groups, with seventeen clones associated with BPH and six clones with PCa, with important implications for the immune response associated with the tumor process. Additionally, we have developed an immunosensor based on colored latex microspheres and exclusion chromatographic columns, where microagglutinates of the antigen-antibody complex were separated by size. Red colored latex microspheres activated with aldehyde groups were coupled with filamentous bacteriophages displaying the selected mimotopes in fusion with its pIII protein surface, which has favored the formation of the antigen-antibody or peptide-protein complexes, amplifying the optical detection during the chromatographic separation of the microagglutinates. This new technology has proven to be fast, very sensitive and specific for detection of circulating antibodies of patients with PCa and BPH.