tbuckley/cabot-search huggingface dataset:
Risk of Thromboembolism in Patients with Paroxysmal Nocturnal Hemoglobinuria Presenting with Both Clinical Symptoms and Elevated Hemolysis
Authors: Jong-Wook Lee, Jun Ho Jang, Jin Seok Kim, Sung-Soo Yoon, Je Hwan Lee, Yeo-Kyeoung Kim, Deog-Yeon Jo, Jooseop Chung, Sang Kyun Sohn
Journal: Blood (2012)
Clinical Evidence That Oct-4+ ssea-4+ Very Small Embryonic Like Stem Cells (VSEL) Are Mobilized into Peripheral Blood in Patients with Acute Myocardial Infarction (AMI): A Novel Prognostic Indicator
Authors: Wojciech Wojakowski, Michal Tendera, Magdalena Kucia, Ewa K Zuba-Surma, Edyta Paczkowska, Joanna Ciosek, Maciek Halasa, Marek Krol, Maciej Kazmierski, Andrzej Ochala, Janina Ratajczak, Mariusz Z Ratajczak
Journal: Blood (2008)
C-Terminal Deletion Mutation of CD20 in B-Cell Malignancy Is Related to a Risk of Relapse and Resistance to Chimeric Anti-CD20 Antibody Therapy.
Authors: Yasuhito Terui, Yuji Mishima, Natsuhiko Sugimura, Kiyotsugu Kojima, Ryoko Kuniyoshi, Akiko Rokudai, Yuko Mishima, Masahiro Yokoyama, Kengo Takeuchi, Kiyohiko Hatake
Journal: Blood (2006)
Association of A313g Glutathione S-Transferase P1 (GSTP1) Inborn Polymorphism with Susceptibility to De Novo MDS
Authors: Sophia Zachaki, Chryssa Stavropoulou, Aggeliki Daraki, Marina Kalomoiraki, Panagoula Kollia, Vassiliki Aleporou, Gabriel Pantelias, Emmanuel Kanavakis, Constantina Sambani
Journal: Blood (2012)
Improving the Rotterdam European Randomized Study of Screening for Prostate Cancer Risk Calculator for Initial Prostate Biopsy by Incorporating the 2014 International Society of Urological Pathology Gleason Grading and Cribriform growth
Authors: Monique J. Roobol, Jan F.M. Verbeek, Theo van der Kwast, Intan P. Kümmerlin, Charlotte F. Kweldam, Geert J.L.H. van Leenders
Journal: European Urology (2017)
Thalidomide in Relapsed or Refractory Patients with Multiple Myeloma: Monotherapy or Combination Therapy? A Report from Systematic Reviews.
Authors: Axel Glasmacher, Corinna Hahn, Florian Hoffmann, Kerstin Furkert, Marie von Lilienfeld-Toal, Katjana Orlopp, Ralph Naumann, Hartmut Goldschmidt, Ingo G.H. Schmidt-Wolf, Marcus Gorschlueter
Journal: Blood (2005)
Does Polyoma (BK) Virus Contribute to Development of Hemorrhagic Cystitis (HC) in Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation (UD HSCT) Recipients? A Prospective Evaluation.
Authors: Poliana A. Patah, Nicholas A. Szewczyk, Lisa Gilman, Alison Gulbis, Joyce Neumann, Julia A. Walker, Demetrios Petropoulos, Maha El-Zimaity, Paolo Anderlini, Jeffrey Tarrand, Richard E. Champlin, Marcos de Lima
Journal: Blood (2006)
Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture
Authors: Wei Zhu, Xin Qu, Jie Zhu, Xuanyi Ma, Sherrina Patel, Justin Liu, Pengrui Wang, Cheuk Sun Edwin Lai, Maling Gou, Yang Xu, Kang Zhang, Shaochen Chen
Journal: Biomaterials (2017)
Low initial cell dose and escalating dose regimen is the best method of administering unmanipulated donor lymphocytes for relapsed chronic myelogenous leukemia.
Authors: C Guglielmi, W Arcese, F Dazzi, R Brand, D Bunjes, LF Verdonck, A Schattenberg, HJ Kolb, P Ljungman, A Devergie, A Bacigalupo, M Gomez, M Michallet, A Elmaagacli, A Gratwohl, J Apperley, D Niederwieser
Journal: Blood (2002)
A Common Single Nucleotide Polymorphism in the Chromosome 7q22.3 Region, Which Is Frequently Deleted in Myeloid Malignancies, Is Associated with Mean Platelet Volume and Platelet Function in Healthy Individuals
Authors: Nicole Soranzo, Marloes R. Tijssen, Augusto Rendon, Christine Meisinger, Chris I. Jones, Christian Gieger, Nicholas A. Watkins, Stephan Menzel, Holger Prokisch, Jonathan Stephens, Angela Doering, Wendy N. Erber, Simon C. Potter, Philippa Burns, Jennifer Jolley, Mario Falchi, Stephen F. Garner, Angela Rankin, Swee Lay Thein, H-Erich Wichmann, Alison H. Goodall, Thomas Illig, Tim D. Spector, Panos Deloukas, Willem H. Ouwehand
Journal: Blood (2008)
Factors Associated with Worsening Proliferative Diabetic Retinopathy in Eyes Treated with Panretinal Photocoagulation or Ranibizumab
Authors: Susan B. Bressler, Wesley T. Beaulieu, Adam R. Glassman, Jeffrey G. Gross, Lee M. Jampol, Michele Melia, Mark A. Peters, Michael E. Rauser
Journal: Ophthalmology (2017)
Supporting relatives and carers at the end of a patient’s life
Authors: M Berry, E Brink, J Harris, K E Sleeman
Journal: BMJ (2017)

How people die remains in the memory of those who live on" -Cicely Saunders All doctors, irrespective of their specialty or the setting in which they work, will care for patients who die.Around half of all deaths occur in hospitals. 1 Evidence suggests that the quality of communication around this process is poorer in hospitals than in other settings, according to responses from relatives who have experienced bereavement. 2Over half of NHS complaints concern care of the dying. 3 Practice PRACTICE What you need to knowEffective support can make a considerable difference to the relatives of people who are dying; helping to allay fears, reducing stress and anxiety, and minimising suffering in bereavement.Clear communication around practical considerations (death certificate, funeral arrangements, information around autopsy, etc) and psychosocial support (normalising grief, cultural and spiritual considerations) is key.Doctors need to familiarise themselves with local systems and protocols.Written communication in addition to verbal is beneficial.PRACTICE
An action-specific effect on perception that avoids all pitfalls
Authors: Jessica K Witt, Mila Sugovic, Nathan L Tenhundfeld, Zachary R King
Journal: Behavioral and Brain Sciences (2016)

Abstract The visual system is influenced by action. Objects that are easier to reach or catch look closer and slower, respectively. Here, we describe evidence for one action-specific effect, and show that none of the six pitfalls can account for the results. Vision is not an isolate module, as shown by this top-down effect of action on perception.
Pregnancy after bariatric surgery: screening for gestational diabetes
Authors: Safwaan Adam, Basil Ammori, Handrean Soran, Akheel A Syed
Journal: BMJ (2017)

Safer alternatives are needed to traditional test

Obesity affects a quarter of adult women in the UK, western Europe, and Canada, and a third in the US. More women than men have bariatric surgery every year,1 and most are of childbearing age. Of 12 869 women in the UK who had primary bariatric surgery in 2011-13, 8469 (66%) were younger than 50.1 Furthermore, fertility in obese women generally improves after bariatric surgery as menstrual irregularity and ovulatory problems resolve with weight loss.23 Thus, increasing numbers of women with obesity start or complete their families after bariatric surgery.

Despite weight loss after surgery, many women still require screening for gestational diabetes mellitus during pregnancy. A history of bariatric surgery has important implications for the choice of test since an oral glucose tolerance test can trigger dumping syndromes, with serious adverse effects.

The two most common primary bariatric procedures, Roux-en-Y gastric bypass (54%) and sleeve gastrectomy (20%),1 can both cause …
BUNGEE JUMPING INHIBITS INNATE IMMUNITY BUT ACTIVATES COAGULATION AND VASCULAR ENDOTHELIUM
Authors: J. de Metz, D. J. van Westerloo, G. Choi, E. Lowenberg, J. Truijen, A. F. de Vos, E. Endert, M. Levi, M. J. Peppelenbosch, T. van der Poll
Journal: Intensive Care Medicine (2009)
Response Adapted Therapy Using Single Agent Lenalidomide in Older Adults with Newly Diagnosed Standard Risk Multiple Myeloma
Authors: Rachid Baz, Melissa Alsina, Kenneth H. Shain, Jennifer Paleveda, Nancy Hillgruber, Elizabeth Finley-Oliver, Leonel Ochoa, Taiga Nishihori, William Dalton, Daniel Sullivan
Journal: Blood (2012)
Iodofiltic Acid I 123 (BMIPP) Fatty Acid Imaging Improves Initial Diagnosis in Emergency Department Patients With Suspected Acute Coronary Syndromes
Authors: Michael C. Kontos, Vasken Dilsizian, Fred Weiland, Gordon DePuey, John J. Mahmarian, Ami E. Iskandrian, Timothy M. Bateman, Gary V. Heller, Karthik Ananthasubramaniam, Yong Li, Jonathan L. Goldman, Tom Armor, Katherine A. Kacena, Norman D. LaFrance, Ernest V. Garcia, John W. Babich, James E. Udelson
Journal: Journal of the American College of Cardiology (2010)
Comprehensive genomic profiling (CGP) of advanced cancers to identify MET exon 14 alterations that confer sensitivity to MET inhibitors.
Authors: Garrett Michael Frampton, Siraj Mahamed Ali, Mark Rosenzweig, Jonathan Wade Goldman, Carrie B. Lee, Jared Weiss, Jose A. Bufill, Ravi Salgia, Mohammad Jahanzeb, Kartik Konduri, Patrick M. Forde, Deborah Morosini, Jeffrey S. Ross, Sai-Hong Ignatius Ou, Roman Yelensky, Vincent A. Miller, Philip J. Stephens
Journal: Journal of Clinical Oncology (2015)

11007 Background: Amplifications and activating mutations in the c-MET proto-oncogene are known oncogenic drivers that have proven responsive to targeted therapy. Alterations affecting the splice sites of MET exon 14 have been identified, which cause exon skipping, MET activation, and predict sensitivity to MET inhibitors in vitro. We undertook comprehensive genomic profiling (CGP) of a large series of advanced cancers to identify MET exon 14 alterations. Methods: DNA was typically extracted from 40 microns of FFPE sections from 34,735 cases examined between April 2012 and January 2015. CGP was performed on hybridization-captured, adaptor ligation based libraries to a mean coverage depth of > 500x. All classes of genomic alterations (GA) were evaluated. Results: CGP of 34,735 patients identified 200 cases harboring METex14 alterations. The alterations had diverse sequence composition, with > 100 distinct sequence variants represented. The 200 patients had a median age of 68.2 years (range 15-83), with 86 males and 114 females. The cases were comprised of lung carcinoma (173), carcinomas of unknown primary (14), brain glioma (6), and one each of adrenal cortical carcinoma, hepatocellular carcinoma, melanoma, Merkel cell carcinoma renal cell carcinoma, rhabdomyosarcoma, sarcoma NOS, and synovial sarcoma. The majority were stage IV. Identification of this alteration via CGP in routine clinical care has led to treatment with MET inhibitors such as crizotinib, and to durable partial responses or better exceeding 3 months in histiocytic sarcoma (1), sarcomatoid lung carcinoma (1), and nsclc (1+). Multiple patients (5+) have initiated treatment on either crizotinib or MET inhibitors in clinical development, and additional outcome data will be reported. Conclusions: MET exon 14 alterations define a hereto unrecognized population of advanced cancers. Early reports of patients demonstrate cases harboring such alterations are responsive to multiple small molecule MET inhibitors. This finding expands the population of advanced cancer patients who can derive benefit from MET-targeted therapies.
Molecular Lesions Associated with Loss of Heterozygosity Identified in CMML.
Authors: Anna M. Jankowska, Hideki Makishima, Rebecca D Ganetzky, Monika Jasek, Heather Cazzolli, Courtney Prince, Manuel Afable, Christine O'Keefe, Ramon V. Tiu, Heesun J. Rogers, Eric D. Hsi, Mikkael A. Sekeres, Michael A McDevitt, Jaroslaw P. Maciejewski
Journal: Blood (2009)
The Potential for Lost Productivity and Daily Activity Impairment in Patients with Follicular (FL) and Other Indolent Non-Hodgkin’s Lymphoma (NHL).
Authors: Matthew C. Cheung, Kevin R. Imrie, Jessica Friedlich, Rena Buckstein, Lisa K. Hicks, Yael Zaretsky, Brigette Hales, Eugenia Piliotis, Nicole Mittmann
Journal: Blood (2006)
Cord Blood Derived CD34+ and AC133+ Progenitor Cells Ex-Vivo Expanded in the Presence of Tetraethylenepentamine: Reproducibility among Cord Blood Units.
Authors: F. Grynspan, T. Peled, N. Rosenheimer-Goudsmid, L. Hana, N. Hasson, J. Mandel, E. Landau, E. Glukhman, A. Harel, D. Yudin, S. Adi, E. Olesinski, Y. Daniely, A. Hasson, D. Harati, A. Nagler, E. Fibach, E. Shpall
Journal: Blood (2004)
Giant thymic cyst mimicking a unilateral pleural effusion
Authors: Anita Nguyen, Hameed Habib, Wael I Awad
Journal: Thorax (2017)

A 24-year-old woman presented to hospital with a 3-day history of right-sided chest pain and worsening shortness of breath. On examination, stony dullness of the right side of the chest was noted. Blood tests showed raised inflammatory markers (erythrocyte sedimentation rate 87 mm/hour, C-reactive protein 338 mg/L), but the remainder of the investigations were unremarkable. A chest radiograph was reported as showing a large right-sided pleural effusion with atelectasis of the right lower lobe (figure 1A), with a recommendation for percutaneous drainage by the radiologists. A percutaneous pleural pigtail catheter was inserted, but only 200 mL of fluid was drained; this showed reactive mesothelial and inflammatory cells, but no evidence of malignancy and negative cultures. A CT scan of the chest subsequently revealed a 21×16 cm cyst almost filling the right hemithorax (figure 1B–D). The patient was discussed at the multi-disciplinary team …
The Role of PET Scan Imaging In Waldenstrom Macroglobulinemia
Authors: Ranjit Banwait, Federico Campigotto, Edie Weller, Brianna Harris, Dilek Yarar, Aldo M. Roccaro, Meghan Rourke, Renee Leduc, Xavier Leleu, Irene M. Ghobrial
Journal: Blood (2010)
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis
Authors: Rui Wang, Bobae V Kim, Madelon van Wely, Neil P Johnson, Michael F Costello, Hanwang Zhang, Ernest Hung Yu Ng, Richard S Legro, Siladitya Bhattacharya, Robert J Norman, Ben Willem J Mol
Journal: BMJ (2017)

Abstract Objective To compare the effectiveness of alternative first line treatment options for women with WHO group II anovulation wishing to conceive. Design Systematic review and network meta-analysis. Data sources Cochrane Central Register of Controlled Trials, Medline, and Embase, up to 11 April 2016. Study selection Randomised controlled trials comparing eight ovulation induction treatments in women with WHO group II anovulation: clomiphene, letrozole, metformin, clomiphene and metformin combined, tamoxifen, gonadotropins, laparoscopic ovarian drilling, and placebo or no treatment. Study quality was measured on the basis of the methodology and categories described in the Cochrane Collaboration Handbook. Pregnancy, defined preferably as clinical pregnancy, was the primary outcome; live birth, ovulation, miscarriage, and multiple pregnancy were secondary outcomes. Results Of 2631 titles and abstracts initially identified, 54 trials reporting on 7173 women were included. All pharmacological treatments were superior to placebo or no intervention in terms of pregnancy and ovulation. Compared with clomiphene alone, both letrozole and the combination of clomiphene and metformin showed higher pregnancy rates (odds ratio 1.69, 95% confidence interval 1.33 to 2.14; 1.71, 1.28 to 2.27; respectively). Letrozole led to higher live birth rates when compared with clomiphene alone (1.67, 1.11 to 2.49). Metformin led to lower multiple pregnancy rates compared with clomiphene alone (0.22, 0.05 to 0.93). Conclusions In women with WHO group II anovulation, letrozole and the combination of clomiphene and metformin are superior to clomiphene alone in terms of pregnancy. Compared with clomiphene alone, letrozole is the only treatment showing a significantly higher rate of live birth. Systematic review registration PROSPERO CRD42015027579. Readers’ note This is the second version of this paper. The original version was corrected following the retraction of two studies and removal of another which were ineligible (references 40, 41, and 75 of the original paper). These studies are not shown in this version. A tracked changes version of the original version is attached as a supplementary file to the correction notice, which explains the issue further.
Individualizing IPSS Risk Assessment in Myelodysplastic Syndromes, by Additionally Taking into Account Age, Gender and French-American-British (FAB) Classification - A Multicenter Analysis.
Authors: Thomas Noesslinger, Heinz Tuechler, Ulrich Germing, Peter Valent, Otto Krieger, Detlev Haase, Reinhard Stauder, Michael Pfeilstocker
Journal: Blood (2006)
Reduced-Intesity Allogeneic HSCT in Hematologic Malignancies: Influence of Underlying Diagnosis and Prior Autograft on Outcome.
Authors: Jayesh Mehta, Leo Gordon, Martin Tallman, Jane Winter, Stephanie Williams, Olga Frankfurt, Andrew Evens, David Grinblatt, Lynne Kaminer, Richard Meagher, Kamran Rashid, Donna Grabowski, Seema Singhal
Journal: Blood (2006)
Germ-Line Genetic Variations in TP53 and Risk for Pediatric Acute Lymphoblastic Leukemia.
Authors: Toralf Bernig, Laurie Burdette, Thomas Lehrnbecher, Ulrike B. Graubner, Monique L. den Boer, Rob Pieters, Gritta E. Janka-Schaub, Stephen J. Chanock
Journal: Blood (2004)
Race-dependent association of sulfidogenic bacteria with colorectal cancer
Authors: Cemal Yazici, Patricia G Wolf, Hajwa Kim, Tzu-Wen L Cross, Karin Vermillion, Timothy Carroll, Gaius J Augustus, Ece Mutlu, Lisa Tussing-Humphreys, Carol Braunschweig, Rosa M Xicola, Barbara Jung, Xavier Llor, Nathan A Ellis, H Rex Gaskins
Journal: Gut (2017)

<h3>Objective</h3> Colorectal cancer (CRC) incidence is higher in African Americans (AAs) compared with non-Hispanic whites (NHWs). A diet high in animal protein and fat is an environmental risk factor for CRC development. The intestinal microbiota is postulated to modulate the effects of diet in promoting or preventing CRC. Hydrogen sulfide, produced by autochthonous sulfidogenic bacteria, triggers proinflammatory pathways and hyperproliferation, and is genotoxic. We hypothesised that sulfidogenic bacterial abundance in colonic mucosa may be an environmental CRC risk factor that distinguishes AA and NHW. <h3>Design</h3> Colonic biopsies from uninvolved or healthy mucosa from CRC cases and tumour-free controls were collected prospectively from five medical centres in Chicago for association studies. Sulfidogenic bacterial abundance in uninvolved colonic mucosa of AA and NHW CRC cases was compared with normal mucosa of AA and NHW controls. In addition, 16S rDNA sequencing was performed in AA cases and controls. Correlations were examined among bacterial targets, race, disease status and dietary intake. <h3>Results</h3> AAs harboured a greater abundance of sulfidogenic bacteria compared with NHWs regardless of disease status. <i>Bilophila wadsworthia</i>-specific <i>dsrA</i> was more abundant in AA cases than controls. Linear discriminant analysis of 16S rRNA gene sequences revealed five sulfidogenic genera that were more abundant in AA cases. Fat and protein intake and daily servings of meat were significantly higher in AAs compared with NHWs, and multiple dietary components correlated with a higher abundance of sulfidogenic bacteria. <h3>Conclusions</h3> These results implicate sulfidogenic bacteria as a potential environmental risk factor contributing to CRC development in AAs.
Synthetic Lethal RNAi Screen of the Human Kinome with Cytarabine in Myeloid Leukemias.
Authors: Raoul Tibes, James Bogenberger, Tanner Hagelstrom, Megan E. Buechel, Keertivibha Bhagavatula, Ashish Choudhary, David Azrosa
Journal: Blood (2009)
Melphalan 200 Mg/m2 (Mel200) Versus Melphalan 100 Mg/m2 (Mel100) in Newly Diagnosed Myeloma Patients: A Prospective, Randomized Phase III Study
Authors: Mario Boccadoro, Sara Bringhen, Maria Teresa Petrucci, Antonietta Falcone, Anna Marina Liberati, Roberto Ria, Mariella Grasso, Marco Montanaro, Patrizia Pregno, Andrea Nozza, Francesco Pisani, Tommaso Caravita, Clotilde Cangialosi, Elisabetta Calabrese, Alessandra Larocca, Federica Cavallo, Marina Ruggeri, Pellegrino Musto, Robert Foà, Antonio Palumbo
Journal: Blood (2008)
Results of a Phase I/II Study of DFP-10917, a Nucleoside Analog, Given By Continuous Infusion (CI) in Patients (pts) with Relapsed or Refractory Acute Leukemia
Authors: Hagop Kantarjian, Elias Jabbour, Guillermo Garcia-Manero, Tapan Kadia, Courtney DiNardo, Naval Daver, Gautam Borthakur, Nitin Jain, Jane Waukau, Monica Kwari, Barry Douglas Anderson, Kenzo Iizuka, Cheng Jin, William Plunkett
Journal: Blood (2015)
Cost-Effectiveness of Posaconazole vs Fluconazole in the Prevention of Invasive Fungal Infections among Patients with Graft-Versus-Host Disease (GVHD) in the US.
Authors: Amy K. O’Sullivan, Milton C. Weinstein, Ankur Pandya, David Thompson, Amelia Langston, John Perfect, George Papadopoulos
Journal: Blood (2007)
The Ki67/CD138 Ratio Independently Predicts Overall Survival in the Upfront Treatment of Newly Diagnosed Multiple Myeloma
Authors: Tomer M Mark, Peter Forsberg, Ihsane Ouansafi, Adriana C Rossi, Roger N Pearse, Karen Pekle, Arthur Perry, Morton Coleman, David Jayabalan, Ruben Niesvizky, Scott A Ely
Journal: Blood (2014)
HCP-11WHAT DO YOUNG ADULTS DIAGNOSED WITH CANCER INTEND TO DO WITH UNRESTRICTED GRANT FUNDING?
Authors: Celeste Leach, Kurt Jaeckle
Journal: Neuro-Oncology (2015)

BACKGROUND: In 2012, 41% of young adults in the U.S. enrolled in college. Many have predetermined career goals, but plans may change following a cancer diagnosis. Depletion of financial resources by medical and travel expenses often prompts a search for funding. However, there are limited patient-reported data regarding the purpose for requests of financial support, and how this might relate to career goals of young adults following a cancer diagnosis. METHODS: Demographic data, personal statements, and physician letters were obtained from young (15-30 yr) adults with cancer, applying for unrestricted grant support to a non-profit organization (Nicki Leach Foundation). Demographic data included: age, sex, histologic subtype; treating location [West (W); South (S); Midwest (MW); Northeast (NE)]; type of facility [university (U); academic medical center (AMC); community medical center (CMC)]; independence for activities of daily living (ADL); and time from diagnosis. Patients were asked to specify the primary purpose for use of funding. Descriptive statistical methods were performed. All patients provided written consent for use of data. RESULTS: 247 pts were studied. Mean age was 20 yrs (S.D.-2.97, range, 15-29); 63% were female, and 37% males. Mean time from diagnosis was 20.5 mos. (S.D.-2.97, range 1-245). Patients were from 40 different states (Midwest-30%; South-29%; Northeast-24%; West-17%), and 161 different treatment facilities (CMC-39%; U-36%; AMC-25%). The most frequent cancers included: leukemia (30%); CNS tumors (17%); lymphoma (13%); sarcoma (12%) or other (28%). Most (85%) declared independence for ADL. The most common patient-reported purposes for requesting funding included: college expenses (70%); living expenses (16%); medical expenses (7%); computers (6%); automobiles (2%); or other educational expenses (2%). CONCLUSIONS: In our analysis, 70% of young adults with cancer request financial support for college. We postulate that young patients are not dissuaded from pursuing educational and career goals, despite the uncertainty introduced by a cancer diagnosis.