tbuckley/cabot-search huggingface dataset:
Weight-adjusted Intravenous Reslizumab in Severe Asthma with Inadequate Response to Fixed-Dose Subcutaneous Mepolizumab
Authors: Manali Mukherjee, Fernando Aleman Paramo, Melanie Kjarsgaard, Brittany Salter, Gayatri Nair, Nicola LaVigne, Katherine Radford, Roma Sehmi, Parameswaran Nair
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Rationale: Clinical benefits of fixed-dose 100-mg subcutaneous (SC) mepolizumab in prednisone-dependent patients are modest when sputum eosinophilia is not adequately controlled.Objectives: This study compared treatment response of weight-adjusted intravenous (IV) reslizumab in patients previously treated with 100-mg SC mepolizumab.Methods: Ten prednisone-dependent patients with asthma (sputum eosinophils >3% and blood eosinophils >300 cells/μl), who had previously received mepolizumab (100 mg SC dosed every 4 wk [Q4W]) for at least 1 year, received two infusions of placebo (Q4W) followed by four infusions of 3.0 mg/kg reslizumab Q4W in a single-blind, placebo-controlled sequential trial. Primary outcomes were reduction of eosinophils in sputum and blood. Additional outcomes included FEV1, asthma control questionnaire, eosinophil peroxidase, IL-5, sputum and blood innate lymphoid cells group 2, eosinophil progenitor cells, and autoimmune responses.Measurements and Main Results: IV reslizumab attenuated sputum eosinophils by 91.2% (P = 0.002), blood eosinophil counts by 87.4% (P = 0.004), and sputum eosinophil peroxidase levels by 65.5% (P = 0.03) compared with placebo. Attenuation of both local and systemic eosinophilia was associated with statistically significant improvements in FEV1 (P = 0.004) and asthma control questionnaire five-question instrument scores (P = 0.006). Decrease in percent sputum eosinophil was greater with reslizumab (by 42.7%) compared with mepolizumab (by 5.0%) and this was associated with greater improvement in asthma control questionnaire (P = 0.01; analysis of covariance of Δ between before and after treatment, mepolizumab vs. reslizumab, adjusted for baseline prednisone). Changes in sputum IL-5 and anti–eosinophil peroxidase IgG after anti–IL-5 therapy were predictors of response.Conclusions: Weight-adjusted IV reslizumab was superior to fixed-dose SC mepolizumab in attenuating airway eosinophilia in prednisone-dependent patients with asthma, with associated improvement in asthma control.Clinical trial registered with www.clinicaltrials.gov (NCT 02559791).
Case 28-2017
Authors: Steven M. Holland, Virginia M. Pierce, Randheer Shailam, Krzysztof Glomski, Jocelyn R. Farmer
Journal: New England Journal of Medicine (2017)

A 13-month-old girl presented with pneumonia. Imaging studies revealed splenomegaly, splenic lesions, and diffuse lymphadenopathy. Three months later, her mother presented with right hip pain and a lytic lesion in the femoral neck. Diagnoses were made.
AB1220-HPR The level of adherence of rheumatology patients in slovenia
Authors: D Stanković, M Pavic Nikolic, A Hočevar
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Patient adherence is one of the central factors associated with the control of patient9s symptoms, good functional ability and longevity. Health care professionals have significant role in their daily practice to improve the adherence to medications. <h3>Objectives</h3> We aimed to assess the adherence of patients treated at our secondary/tertiary rheumatology center. <h3>Methods</h3> Data were collected in a prospective manner. We investigated the level of self-reported adherence to treatment in 115 consecutive patients (81 women; mean age (SD) of 56.5±14.7 years) with systemic inflammatory diseases in December 2016. We used the 19-item questionnaire-Compliance-Rheumatology (CQR). <h3>Results</h3> We found optimal adherence in 52% of patients: the average (SD) adherence rate was 71.1±9.42. We didn9t find any significant differences between adherent and nonadherent patients regarding patient age, gender, the diagnosis of rheumatic disease and disease duration time, however, patients with higher education level (at least graduate level) were more compliant than those without any formal education (p=0.006). In addition there was no association between adherence and the type of medication (csDMARD, bDMARD) (p=0.39). Patient data are presented in the table 1. <h3>Conclusions</h3> Our study showed lower adherence rate than expected. To improve patient adherence we should work more in the future on providing additional knowledge and support to patients. <h3>Acknowledgements</h3> Special thanks to our colleagues Tadeja Šušteršič and Albina Stanovnik. <h3>Disclosure of Interest</h3> None declared
Sustained effectiveness and cost-effectiveness of the Healthy Activity Programme, a brief psychological treatment for depression delivered by lay counsellors in primary care: 12-month follow-up of a randomised controlled trial
Authors: Benedict Weobong, Helen A. Weiss, David McDaid, Daisy R. Singla, Steven D. Hollon, Abhijit Nadkarni, A-La Park, Bhargav Bhat, Basavraj Katti, Arpita Anand, Sona Dimidjian, Ricardo Araya, Michael King, Lakshmi Vijayakumar, G. Terence Wilson, Richard Velleman, Betty R. Kirkwood, Christopher G. Fairburn, Vikram Patel
Journal: PLoS Medicine (2017)

The Healthy Activity Programme (HAP), a brief behavioural intervention delivered by lay counsellors, enhanced remission over 3 months among primary care attendees with depression in peri-urban and rural settings in India. We evaluated the sustainability of the effects after treatment termination, the cost-effectiveness of HAP over 12 months, and the effects of the hypothesized mediator of activation on clinical outcomes.
FRI0111 Anti-citrullinated protein antibody reactivities in treatment naÏve early rheumatoid arthritis
Authors: MK Jonsson, AH Hensvold, M Hansson, L Mathsson-Alm, A-B Aga, J Sexton, B-TS Fevang, S Lillegraven, AI Catrina, EA Haavardsholm
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> An increase in the number of anti-citrullinated protein antibodies (ACPA) reactivities precede RA onset, and may be involved in the pathogenesis of the disease. The presence of ACPA is associated with radiographic progression in RA, and it has been suggested that ACPAs with different reactivities may be associated with different phenotypes of RA. <h3>Objectives</h3> To assess the prevalence of baseline ACPA reactivities in an inception cohort of early RA patients, including subgroups based on anti-CCP/RF status, and to compare the findings to healthy controls. <h3>Methods</h3> 217 DMARD-naïve early RA patients from the ARCTIC trial (1) were analysed. Radiographs were scored according to van der Heijde Sharp (vdHS) score. Anti-CCP status was analysed by FEIA (pos. if ≥10 IU/mL) and RF by ELISA (pos. if ≥25 IU/mL). ACPA titres (AU/ml) were considered pos. if above the 98-perc. of values in 619 non-RA subjects. Analysis of 13 ACPA reactivities targeting citrullinated peptides from fibrinogen, alpha-1 enolase, vimentin, fillagrin and histone was performed at baseline in patients and 94 controls (blood donors matched for age/gender/smoking), using a multiplex chip-based assay (2). <h3>Results</h3> Baseline characteristics are presented in the table. The figure shows the prevalence of ACPA reactivities in the subgroups, with median [IQR] number of antibody reactivities in all patients 7 [3,10], compared to 0 [0,0] in controls (p&lt;0.001). The corresponding numbers were 8 [5,10] and 0 [0,1] for the anti-CCP+ vs. anti-CCP- patients (p&lt;0.001), and 8 [5,10] and 2 [0,7.5] for the RF+ vs. RF- patients (p&lt;0.001). Positivity for ACPA reactivities was seen mainly in the anti-CCP+ and RF+ patients, but also occurred more frequently in RF- and anti-CCP- patients (table) than in controls (anti-CCP- vs controls p=0.037, RF- vs controls p&lt;0.001). <h3>Conclusions</h3> Prevalence of ACPA reactivities differed in subgroups of DMARD-naïve early RA patients according to anti-CCP and RF status. All RA subgroups, including RF- and anti-CCP- patients, had higher prevalence of ACPA reactivities compared to healthy controls. <h3>References</h3> Haavardsholm et al BMJ 2016. Hansson et al Arthr Res Ther 2012. <h3>Disclosure of Interest</h3> M. Jonsson: None declared, A. Hensvold: None declared, M. Hansson: None declared, L. Mathsson-Alm Employee of: Thermo Fisher Scientific, A.-B. Aga: None declared, J. Sexton: None declared, B.-T. Fevang Grant/research support from: Novartis, S. Lillegraven: None declared, A. Catrina: None declared, E. Haavardsholm Grant/research support from: AbbVie, MSD, Pfizer, Roche, UCB
THU0443 Hyperuricemia is associated with increased coronary artery calcification in men but not women
Authors: MI Dehlin, P Drivelegka, V Sigurdardottir, O Angerås, LT Jacobsson, H d'Elia Forsblad
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Hyperuricemia is closely associated to cardiovascular disease although it has not been defintively established whether it is a marker or a causative agent. Serum uric acid (sUa) is strongly linked to the metabolic syndrome, hypertension (HT), dyslipidemia (DL) and higher BMI and higher levels are seen in men compared to women. Coronary artery calcification (CAC) is associated with future risk of atherosclerotic CV events in addition to these traditional cardiovascular risk factors (CVRF). CACs are present in atherosclerotic arteries and can be quantified and scored non-invasively by computed tomography. The Swedish CArdioPulmonarybioImage Study (SCAPIS) extensively characterizes a Swedish cohort of 30 000 men and women aged between 50 and 64 years. A comprehensive pilot study in 1111 individuals was completed in 2012. In this pilot study we have examined the relation between CACs and sUa <h3>Objectives</h3> Examine the association bewteen sUa and CAC in men and women seperately. <h3>Methods</h3> In the SCAPIS pilot study we identified 1106 (552 males) individuals who were screened for traditional CVDRFs, such as HT, DL, diabetes mellitus (DM), smoking, physical activity (PA), educational level (EDU), BMI, high sensitive CRP (hsCRP). CACs, reflecting calcification of coronary arteries, was determined according to Agatston<sup>1</sup>. We measured sUa and related quartiles to CACs with multiple logistic regression analyses adjusting for traditional CVDRFs. CAC was defined positive if ≥1. <h3>Results</h3> Age, BMI, smoking status, hsCRP, HT and DL showed no differences between sex while presence of CAC and diabetes was twice as common in men (Table 1). The three upper quartiles of sUa, (&gt;306 μmol/L), all significantly (p&lt;0.05) predicted presence of CACs in men even adjusting for HT, DL, DM, smoking, PA, EDU, BMI, hsCRP and age in multivariate logistic regression, but not in women (Table 2). <h3>Conclusions</h3> Higher levels of sUa is associated with presence of CACs in men but not in women. This may merely reflect the earlier onset of atherosclerosis in men or possibly suggest biological differences in the effect of sUa on calcification of coronary arteries between sexes. <h3>References</h3> Agatston AS et al Quantification of coronary artery calcium using ultrafast computed tomography J Am Coll Cardiol 1990. <h3>Disclosure of Interest</h3> None declared
THU0283 Resilience and associated factors among women with systemic lupus erythematosus
Authors: P Munguía-Realpozo, M García-Carrasco, J Leόn-Vázquez, MF Balcazar-Vargas, EA Jiménez-Herrera, I Etchegaray-Morales, C Mendoza Pinto
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Resilience is the human capacity to respond positively to adverse situations, enabling individuals to achieve, maintain, or recover physical or emotional health after devastating illness, losses, or other stressful situations. Resilience may be an important factor in health promotion. <h3>Objectives</h3> The aim of this study was to evaluate resilience and possible associated factors in patients with systemic lupus erythematosus (SLE). <h3>Methods</h3> In a cross-sectional study, 123 SLE women and 133 age-matched controls were evaluated using the Spanish version of Wagnild and Young9s Resilience Scale (WYRS, 1993). SLE patients underwent a structured interview to collect sociodemographic data, including socioeconomic status measured by the Graffar method. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to measure depressive symptoms. <h3>Results</h3> The median age and duration disease of SLE women was 45 (IQR: 34–54) years and 11 (IQR: 8–15) years, respectively. Thirty-three percent had depressive symptoms (CESD score ≥16). Resilience scores did not differ between patients and controls (median 80 IQR: 75–87 vs.80 IQR: 74–85;p=0.38). However, patients with SLE had a higher personal competence factor than controls. Personal competence factor correlated negatively with age and socioeconomic status (R= -0.220, p: 0.05 and R= -0.357, p&lt;0.001) and positively with educational level (R=0.324, p&lt;0.001). Less resilience (lower WYRS scores) correlated with depressed mood (higher CESD scores) (R= -0.537, p&lt;0.001). <h3>Conclusions</h3> Resilience in patients with SLE did not differ from that of controls. Age, socioeconomic status and depressive symptoms correlated with low resilience. Educational level correlated with higher resilience. <h3>References</h3> Windle G, Bennett K, Noyes J. A methodological review of resilience measurement scales. Health Qual Life Outcomes. 2011; 9(8): 1–18. Pousa DA, Revoredo LS, Vilar MJ and Chavez EM. Resilience and Treatment Adhesion in Patients with Systemic Lupus Erythematosus. Open Rheumatol J. 2014; 8: 1–8. <h3>Acknowledgements</h3> We would like to thank David Buss for his valuable guidance and advice during this project. <h3>Disclosure of Interest</h3> None declared
AB0975 Incidence of infections with biological therapies in paraguayan children with juvenile idiopathic arthritis: biobadaguay (biological therapies adverse events paraguayan-uruguayan register)
Authors: Z Morel, P De Abreu, I Acosta, G Avila, S Cabrera
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Biological Therapies (BT) are important in the therapeutic arsenal of rheumatic diseases; however there is an increased risk of infections with their use. <h3>Objectives</h3> To determine the frequency and type of infections in Paraguayan patients with Juvenile Idiopathic Arthritis (JIA), included in the BIOBADAGUAY Register. <h3>Methods</h3> A prospective observational study of patients with JIA treated with BT, included in the BIOBADAGUAY Register. Patients at the onset of BT were included. The change and/or discontinuation of BT and the occurrence of adverse events (AEs) were recorded. Infectious events as affected organ, type, severity, outcome and need of temporary or permanent suspension of the biological agent were analyzed. <h3>Results</h3> 59 patients with JIA and 69 BT were identified between May 2012 and December 2016. Female: 63% (37), Men: 37% (22). The mean age was 10 (3–18) years old. Mean disease progression of 2.8 (0.2–12) years from the diagnosis to BT beginning. JIA subtypes: poliarticular negative RF (27%), oligoarticular (27%: extended 22% and persistent 5%), enthesitis related arthritis (21%), systemic (12%), poliarticular positive RF (7%), psoriatic (3%), other (indeterminate) (3%). Biologic treatments: Adalimumab (ADM) 41 (59%), Etanercept (ETN) 19 (28%), Tolicizumab (TCZ) 9 (13%). There were 83 AEs of all treatments, 80 (96%) no serious and 3 (4%) severe with 1 death. Infections and infestations 54 (65%) of AEs were recorded. Of all TB infections: the 94% (51) were not serious and the 63% (34) required temporal discontinuation. Most infectious recovered without sequelae, except one death due to pneumonia (Table 1). <h3>Conclusions</h3> 1) Infections and infestations (65%) were the AEs more frequently observed. 2) Of al Infections, respiratory tract iwere the most frequently observed. 3) Most of the infections were not serious and recovered without sequela. 4) The most frequently agent involved in infectious events was ADM (52% of all infections); even so it is most frequently administered agent. 5) Increased number of patients, greater diversity of treatment as well as a longer data to corroborate the observation period is required. <h3>Disclosure of Interest</h3> None declared
Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection
Authors: Mo‐Yuan Shen, Jie‐Fu Chen, Chun‐Hao Luo, Sangjun Lee, Cheng‐Hsuan Li, Yung‐Ling Yang, Yu‐Han Tsai, Bo‐Cheng Ho, Li‐Rong Bao, Tien‐Jung Lee, Yu Jen Jan, Ya‐Zhen Zhu, Shirley Cheng, Felix Y. Feng, Peilin Chen, Shuang Hou, Vatche Agopian, Yu‐Sheng Hsiao, Hsian‐Rong Tseng, Edwin M. Posadas, Hsiao‐hua Yu
Journal: Advanced Healthcare Materials (2017)

Abstract A glycan‐stimulated and poly(3,4‐ethylene‐dioxythiophene)s (PEDOT)‐based nanomaterial platform is fabricated to purify circulating tumor cells (CTCs) from blood samples of prostate cancer (PCa) patients. This new platform, phenylboronic acid (PBA)‐grafted PEDOT NanoVelcro, combines the 3D PEDOT nanosubstrate, which greatly enhances CTC capturing efficiency, with a poly(EDOT‐PBA‐ co ‐EDOT‐EG3) interfacial layer, which not only provides high specificity for CTC capture upon antibody conjugation but also enables competitive binding of sorbitol to gently release the captured cells. CTCs purified by this PEDOT NanoVelcro chip provide well‐preserved RNA transcripts for the analysis of the expression level of several PCa‐specific RNA biomarkers, which may provide clinical insights into the disease.
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product
Authors: Maria V. Liberti, Ziwei Dai, Suzanne E. Wardell, Joshua A. Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, Mahya Mehrmohamadi, Marc O. Johnson, Neel S. Madhukar, Alexander A. Shestov, Iok I. Christine Chio, Olivier Elemento, Jeffrey C. Rathmell, Frank C. Schroeder, Donald P. McDonnell, Jason W. Locasale
Journal: Cell Metabolism (2017)
Positive Captopril Renography Without Renal Artery Stenosis but a Renal Cell Carcinoma
Authors: Ping-Ju Hsieh, Yen-Shu Kuo, Meng-Lin Chen, Ching-Ling Lin, Hung-Yi Su
Journal: Clinical Nuclear Medicine (2017)

Abstract A positive captopril renography indicates that patient's hypertension is renin dependent, most commonly caused by renal artery stenosis. The authors reported a case of positive captopril renography; however, CT demonstrated that renal arteries were intact, but there was a huge chromophobe renal cell carcinoma. Renin-dependent hypertension was relieved soon after nephrectomy. It is an uncommon cause of positive captopril renography.
SP0078 Can imaging be a predictor of psoriatic disease?
Authors: M Østergaard
Journal: Annals of the Rheumatic Diseases (2017)

Early detection of inflammatory joint diseases is very important to allow prompt initiation of effective therapies. Identifying patients with early arthritic disease can be challenging by conventional clinical, laboratory and radiographic methods, and more advanced imaging modalities such as computed tomography (CT), magnetic resonance imaging, ultrasonography (US) and various nuclear medicine techniques can provide additional information. This talk describes the current knowledge on the value of different imaging modalities for 1) predicting development of psoriatic disease in undifferentiated patients 2) predicting development of psoriatic arthritis (PsA) in patients with psoriasis with and without musculoskeletal pain and 3) predicting the disease course in patients with PsA. <h3>Disclosure of Interest</h3> None declared
Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail
Authors: Boris Julg, Po-Ting Liu, Kshitij Wagh, William M. Fischer, Peter Abbink, Noe B. Mercado, James B. Whitney, Joseph P. Nkolola, Katherine McMahan, Lawrence J. Tartaglia, Erica N. Borducchi, Shreeya Khatiwada, Megha Kamath, Jake A. LeSuer, Michael S. Seaman, Stephen D. Schmidt, John R. Mascola, Dennis R. Burton, Bette T. Korber, Dan H. Barouch
Journal: Science Translational Medicine (2017)

A combination of HIV-1–specific broadly neutralizing antibodies is necessary to protect rhesus monkeys against a mixed SHIV challenge.
A novel IKAROS haploinsufficiency kindred with unexpectedly late and variable B-cell maturation defects
Authors: Delfien J. Bogaert, Hye Sun Kuehn, Carolien Bonroy, Katherine R. Calvo, Joke Dehoorne, Arnaud V. Vanlander, Marieke De Bruyne, Urszula Cytlak, Venetia Bigley, Frans De Baets, Elfride De Baere, Sergio D. Rosenzweig, Filomeen Haerynck, Melissa Dullaers
Journal: Journal of Allergy and Clinical Immunology (2017)
AB0732 Spondyloarthritis in the democratic republic of congo
Authors: P Lebughe, K de Vlam, R Westhovens, J-M Mbuyi-Muamba, J-J Malemba
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> While spondyloarthritis (SpA) is intensively studied in the Western world, data are scarce in sub-Saharan Africa. <h3>Objectives</h3> To determine the spectrum of SpA in outpatients with rheumatological complaints attending two rheumatology practices in Kinshasa, Democratic Republic of Congo. <h3>Methods</h3> A descriptive cross-sectional study over six months (December 1st, 2012 till May 31th, 2013) in consecutive patients attending the two rheumatology practices of Kinshasa; diagnosis was based on Amor or the ESSG criteria, and a clinical evaluation by a rheumatologist. Sacroiliac joint radiographic lesions were scored with the modified New York criteria. BASDAI and BASFI were evaluated in axial SpA. <h3>Results</h3> One hundred five patients (10.7%) were diagnosed among 984 rheumatologic outpatients with a sex ratio (male to female) of 1.4. The average age at the onset of the disease was 41.3±12.4 years. Non-radiographical axial spondyloarthritis was the most frequent subtype (4.98%) followed by reactive arthritis (4.27%). Other subtypes were: ankylosing spondylitis (1.02%), psoriatic arthritis (0.1%), SAPHO syndrome (0.1%) and IBD associated arthritis (0.1%). Mean BASDAI and BASFI in axial SpA were 42.7/100 and 46.4/100 respectively. Peripheral enthesitis was found in 43% of SpA patients and uveitis (10.4%) was the most frequent extra-articular manifestation. We did not detect any family history. Median erythrocyte sedimentation rate and C reactive protein were 37 (range: 7–110) mm/h and 22 (range: 4–48) mg/l respectively. <h3>Conclusions</h3> This hospital-based study suggests a substantial occurrence of some subtypes of SpA in central Africa. A population-based study is needed. <h3>References</h3> Malemba JJ, Mbuyi-Muamba JM. Clinical and epidemiological features of rheumatic diseases in patients attending the university hospital in Kinshasa. Clin Rheumatol. 2008;27:47–54. Stolwijk C, van Onna M, Boonen A, van Tubergen A. Global Prevalence of Spondyloarthritis: A Systematic Review and Meta-Regression Analysis. Arthritis Care Res (Hoboken). 2015 Dec 29. <h3>Acknowledgements</h3> The authors would like to thank Dr Thierry Lusiense for helping with acquisition of data from the Rheumatology unit at Provincial General Hospital Kinshasa. <h3>Disclosure of Interest</h3> None declared
What are the risks of oestrogens in women assigned male at birth and how should they be monitored?
Authors: Jacq Hawkins
Journal: BMJ (2017)

As a general practitioner, I am uncertain about hormonal treatment and its monitoring in patients with gender dysphoria. Barrett mentions that women who were assigned male at birth do not need screening mammography because their risk of breast cancer is very low as their hormonal treatment does not include progestogens.1 What are the other risks …