tbuckley/cabot-search huggingface dataset:
Mucosectomie colorectale fragmentaire étendue pour des tumeurs dépassant 4cm: une alternative à la dissection sous-muqueuse?
Authors: P Ah Soun, A Desjeux, V Vitton, JC Grimaud, M Barthet
Journal: Endoscopy (2009)

Introduction: La résection de tumeurs pariétales étendue (&gt;4cm) en monobloc est impossible techniquement. La dissection sous-muqueuse (ESD) est proposée comme une alternative à la mucosectomie étendue par fragments. Le but de cette étude était d'évaluer la faisabilité et l'efficacité de la mucosectomie par fragments pour le traitement des tumeurs colorectales étendues (TCRE) &gt;4cm.
Test d'étanchéitéà l'hydrogène dilué: un outil non-invasif, rapide, quantitatif et spécifique, développé pour la chirurgie endoscopique transviscérale (NOTES)
Authors: X Dray, SK Redding, EJ Shin, JM Buscaglia, SA Giday, RJ Wroblewski, L Assumpcao, D Mukkai Krishnamurty, P Magno, MR Marohn, AN Kalloo, SV Kantsevoy
Journal: Endoscopy (2009)

Introduction: L'étanchéité d'une suture doit pouvoir être appréciée après chirurgie endoscopique transviscérale (NOTES) afin de prévenir la contamination postopératoire de la cavité péritonéale. L'hydrogène (H2) est un gaz non toxique, non inflammable à basse concentration, volatile et détectable. Objectif: Evaluer un test d'étanchéitéà l'H2 pour la NOTES transgastrique.
The Usefulness of IDUS-Guided Transpapillary Bile Duct Biopsy for the Diagnosis of Malignant Biliary Strictures
Authors: Moon Jong Ho
Journal: Endoscopy (2011)

Background/Aim: Tissue acquisition is the essential for the management of biliary strictures. Fluoroscopically guided transpapillary bile duct biopsy during ERCP may allow the diagnosis of malignancy with limitation by a low sensitivity. IDUS produces a high quality cross sectional image that is useful for the characterization of biliary stricture and can provide optimal biopsy forceps positioning. We compared the diagnostic yields of IDUS-guided transpapillary bile duct biopsy with those of fluoroscopically guided biopsy in tissue diagnosis of malignant biliary stricture.
Concomitant Genetic Alterations With Response to Treatment and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With <i>EGFR</i>-Mutant Advanced Non–Small Cell Lung Cancer
Authors: Shaodong Hong, Fangfang Gao, Sha Fu, Yan Wang, Wenfeng Fang, Yan Huang, Li Zhang
Journal: JAMA Oncology (2018)

This cohort study examines the association of concomitant genetics alterations with response to treatment with epidermal growth factor receptor tyrosine kinase inhibitors among patients with EGFR-mutant advanced non–small cell lung cancer.
Faisabilité de la ponction sous écho-endoscopie chez le malade ayant une prothèse biliaire en place pour un adénocarcinome de la tête du pancréas
Authors: A Aubert, P Lévy, P Ponsot, A Couvelard, F Maire, V Rebours, O Hentic-Dhomé, M Felce-Dachez, L Palazzo, MP Vullierme, P Hammel, P Ruszniewski
Journal: Endoscopy (2009)

Introduction: La sensibilité de la ponction sous écho-endoscopie (PEE) à l'aiguille fine est supérieure à 80% pour le diagnostic d'adénocarcinome du pancréas (ADKP). Elle est inconnue en cas d'ADKP avec endoprothèse biliaire (EPB) en place. Le but de ce travail rétrospectif était d'évaluer la performance diagnostique de la PEE dans cette situation.
LONG-TERM ADVERSE EVENTS DUE TO SELF-EXPANDABLE METALLIC STENTS IN PATIENTS WITH ADVANCED ESOPHAGEAL CANCER
Authors: G Sirin, AE Duman, H Yılmaz, Z Islamoglu, A Celebi, S Hülagu
Journal: Endoscopy (2018)

Self-expandable metallic stents (SEMS) are accepted as best palliative treatment option for patients with advanced esophageal cancer who has already dysphagia. Adverse events (AE), especially in patients who has longer survival expentancy are a major concern. We aimed that to assess the AE of patients with esophageal SEMS who survived longer than 6 months.
Endometriosis
Authors: S. Engemise, C. Gordon, J. C. Konje
Journal: BMJ (2010)

<h3>Background</h3> Intracranial fusiform aneurysms are less common than saccular aneurysms, but are associated with higher mortality and morbidity. We conducted this study to determine the safety and efficacy of the pipeline embolization device (PED) to treat intracranial fusiform aneurysms. <h3>Methods</h3> This was a multicenter, retrospective, and observational study. Data for this study came from the PLUS study conducted from 2014 to 2019 across 14 centers in China. Univariate and multivariable logistic regression analyses were performed to evaluate predictors of the occlusion rate and complication. <h3>Results</h3> A total of 1171 consecutive patients with 1322 intracranial aneurysms participated in this study. Among the participants, 104 patients with 109 fusiform aneurysms were eligible for this analysis (mean age 49 years, 36.5% women, aneurysm mean size 14.7 mm, 55% in the posterior circulation, and 6% in the basilar artery). Mean follow-up time was 9.0 months (range 3–36 months). The last DSA angiographic follow-up was available for 85 patients, and 58 aneurysms (68.2%) were completely occluded. The overall complication rate and mortality were 17.3% and 2.8%, respectively. Multivariate analysis demonstrated that age (OR=1.007, p=0.037) and cerebral atherosclerosis (OR=1.441, p=0.002) were associated with incomplete occlusion of fusiform aneurysms after PED treatment. <h3>Conclusion</h3> PEDs may be an effective treatment for intracranial fusiform aneurysms, with a favorable occlusion rate. However, because these treatments have a relatively high rate of complications, PED treatment for fusiform aneurysms should be carefully and strictly controlled. Our analysis showed that PEDs with adjunctive coiling did not significantly improve the occlusion rate of fusiform aneurysms.
COLLAGENOUS GASTRITIS WITH DYSPLASIA
Authors: J Espinel, M Eugenia Pinedo, C Alvarez Cañas
Journal: Endoscopy (2018)

Collagenous gastritis (GC) is a rare and idiopathic form of chronic gastritis. The presenting symptoms of the pediatric type are usually abdominal pain and anemia due to digestive bleeding. On endoscopy, nodular mucosa changes are seen in the stomach. In adults, the main clinical symtom is diarrhea due to its greater association with collagenous colitis.
Defining Postoperative Opioid Needs Among Preoperative Opioid Users—Reply
Authors: Rebecca E. Scully, Louis L. Nguyen
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 (Cas12a) nucleases in rice
Authors: Xu Tang, Guanqing Liu, Jianping Zhou, Qiurong Ren, Qi You, Li Tian, Xuhui Xin, Zhaohui Zhong, Binglin Liu, Xuelian Zheng, Dengwei Zhang, Aimee Malzahn, Zhiyun Gong, Yiping Qi, Tao Zhang, Yong Zhang
Journal: Genome biology (2018)

Targeting specificity has been a barrier to applying genome editing systems in functional genomics, precise medicine and plant breeding. In plants, only limited studies have used whole-genome sequencing (WGS) to test off-target effects of Cas9. The cause of numerous discovered mutations is still controversial. Furthermore, WGS-based off-target analysis of Cpf1 (Cas12a) has not been reported in any higher organism to date.
“THE DOUBLE TROUBLE”: SEQUENTIAL SAME-SESSION, EUS-GUIDED TREATMENT OF DUODENAL AND BILIARY STENOSIS
Authors: I Tarantino, D Ligresti, L Barresi, F Cipolletta, A Granata, M Traina
Journal: Endoscopy (2018)

Patients with peri-ampullary malignancies may present concomitantly with both Gastric Outlet Obstruction (GOO) and biliary obstruction. Standard access to the biliary tree with ERCP may fail due to malignant luminal compromise. With the recent advent of interventional EUS and dedicated devices like Lumen Opposing Metal Stent (LAMS), EUS-guided management of both GOO and biliary obstruction is now possible.
NOVEL FENESTRATED ENDOSCOPIC SPHINCTEROTOMY FACILITATES HIGH DUCT CLEARANCE OF LARGE COMMON BILE DUCT STONES 10 TO 20MM IN SIZE IN PATIENTS WITH NAïVE AMPULLAS
Authors: F Janjua, C Moran, F Zeb, G Courtney, A Aftab
Journal: Endoscopy (2018)

Electronic recording system (EndoRaad) was used to identify all patients that met our inclusion criteria: CBD stone ≥10 mm and ≤20 mm. Exclusion criteria: previous sphincterotomy, biliary strictures and where the intention was to provide biliary drainage alone and not duct clearance (pregnancy, coagulopathy and patients deemed too frail for intervention). Demographics, duct clearance rates (at index and subsequent procedures), number and size of CBD stones, and anatomical variants were recorded. SPSS v22 was used for statistical analysis.
Randomized phase II trial of autologous dendritic cell vaccines versus autologous tumor cell vaccines in metastatic melanoma: 5-year follow up and additional analyses
Authors: Robert O. Dillman, Andrew N. Cornforth, Gabriel I. Nistor, Edward F. McClay, Thomas T. Amatruda, Carol Depriest
Journal: Journal for ImmunoTherapy of Cancer (2018)

<h3>Background</h3> Despite improved survival following checkpoint inhibitors, there is still a potential role for anti-cancer therapeutic vaccines. Because of biological heterogeneity and neoantigens resulting from each patient's mutanome, autologous tumor may be the best source of tumor-associated antigens (TAA) for vaccines. Ex vivo loading of autologous dendritic cells with TAA may be associated with superior clinical outcome compared to injecting irradiated autologous tumor cells. We conducted a randomized phase II trial to compare autologous tumor cell vaccines (TCV) and autologous dendritic cell vaccines (DCV) loaded with autologous TAA. <h3>Methods</h3> Short-term autologous tumor cell lines were established from metastatic tumor. Vaccines were admixed with 500 micrograms of GM-CSF and injected weekly for 3&nbsp;weeks, then at weeks 8, 12,16, 20, and 24. The primary endpoint was overall survival. Secondary objectives were identification of adverse events, and results of delayed type hypersensitivity (DTH) reactions to intradermal tumor cell injections. <h3>Results</h3> Forty-two patients were randomized. All were followed from randomization until death or for five years; none were lost to follow-up. DCV was associated with longer survival: median 43.4 versus 20.5&nbsp;months (95% CI, 18.6 to &gt; 60 versus 9.3 to 32.3&nbsp;months) and a 70% reduction in the risk of death (hazard ratio = 0.304, <i>p</i> = 0.0053, 95% CI, 0.131 to 0.702). Tumor DTH reactions were neither prognostic nor predictive. The most common treatment-related adverse events were mild to moderate local injection site reactions and flu-like symptoms; but grade 2 treatment-related adverse events were more frequent with TCV. Serum marker analyses at week-0 and week-4 showed that serum markers were similar at baseline in each arm, but differed after vaccination. <h3>Conclusions</h3> This is the only human clinical trial comparing DCV and TCV as platforms for autologous TAA presentation. DCV was associated with minimal toxicity and long-term survival in patients with metastatic melanoma. DTH to autologous tumor cells was neither prognostic for survival nor predictive of benefit for either vaccine. <h3>Trial registration</h3> Clinical trials.gov NCT00948480 retrospectively registered 28 July 2009.
EARLY ONSET COLORRECTAL CANCER: PHENOTYPICAL FEATURES AND ENDOSCOPIC FOLLOW-UP AFTER SURGERY
Authors: Á Cañete Ruiz, J Arribas Anta, D Rueda, S Tapial, C Narvaez, A Vivas, JC Marín Gabriel, JB Díaz Tasende, G Castellano Tortajada, J Perea García
Journal: Endoscopy (2018)

To describe clinical and molecular characteristics of Early Onset Colorectal Cancer (EOCRC, < 45 years) and to identify high-risk groups for recurrence during surveillance after surgery.
MEDICAL MALPRACTICE IN ENDOSCOPY: WHAT ARE WE GETTING WRONG?
Authors: S Budihal, J Mayberry
Journal: Endoscopy (2018)

Endoscopy is not risk free and complications are well documented. Information regarding claims in endoscopy is scarce and little is known about the causes for legal redress. This study aimed to investigate the nature of medico-legal claims in relation to endoscopy in the UK.
In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease
Authors: F. Carli, M. Gaggini, C. Rosso, C. Saponaro, C. Barbieri, V.D. Latta, E. Buzzigoli, D. Ciociaro, M.L. Abate, M. Marietti, R. Younes, E. Bugianesi, A. Gastaldelli
Journal: Journal of Hepatology (2018)
ENDOSCOPIC FULL-THICKNESS RESECTION IN THE COLON – FIRST EXPERIENCE
Authors: P Falt, T Hucl, P Fojtik, P Drastich, J Martinek, R Andelova, L Voska, J Spicak, O Urban
Journal: Endoscopy (2018)

The purpose of the study was to evaluate feasibility, safety and efficiency of endoscopic full-thickness resection (FTR) in the colon.
Abstract 021: Greater Calcium Density of Coronary Artery Plaque is Protective for Cardiovascular Events. The Multi-Ethnic Study of Atherosclerosis
Authors: Michael H Criqui
Journal: Circulation (2013)

Background— Coronary artery calcium (CAC) measured by computed tomography (CT) has strong predictive value for incident cardiovascular disease (CVD) events. The standard CAC score is the Agatston, which is the product of the within slice CAC plaque area and a plaque specific density factor of 1, 2, 3, or 4, summed for all CT slices. Thus, the Agatston score is weighted upward for greater CAC density. However, data from both observational studies and randomized trials suggest increased CAC density per se may be protective for CVD. Methods— In a multi-ethnic population of 3398 men and women with Agatston scores &gt; 0 at baseline, we derived a formula using the individual Agatston scores and the volume scores to create a per participant CAC density score. We then analyzed the independent associations of CAC volume and CAC density with incident hard CVD, defined as MI, resuscitated cardiac arrest, cardiac death, stroke, or stroke death, Results— During a median of 7.6 years of follow-up, there were 265 hard CVD events, 175 of which were coronary heart disease (CHD) events. In a proportional hazards model including the General Framingham Risk Score (GFRS) and both the CAC volume and CAC density score, the CAC volume score showed a strong independent association with incident CVD, with a hazard ratio per natural log standard deviation increase of 1.62, p&lt;.0001. Conversely, the CAC density score showed an independent association that was strongly protective for CVD, with a hazard ratio per standard deviation increase of 0.72, p&lt;.0003. Multivariate quartile analyses showed that at any given volume score, a density score in the 4 th quartile (range 3.2 to 4.0) decreased the risk of a CVD event by 51%, p=.002. The density score showed no significant interactions with either sex or ethnicity. The addition of the volume score to the model containing the GFRS increased the area under the ROC curve (AUC) from 0.664 to 0.6869, p=.015, and further addition of the density score increased the AUC to .6994, p=.023. Separate analyses limited to CHD events showed similar results. Conclusions— At any given volume of CAC, increased density in calcified coronary plaques is protective for incident CVD, consistent with the concept that calcium deposition may increase the stability of atherosclerotic plaques. CAC scoring systems should be modified to weight downward for density rather than upward, and thus improve CVD risk prediction.
COMPARISON BETWEEN AN ASYMMETRIC AND SYMMETRIC SPLIT-DOSE REGIMEN OF POLYETHYLENE GLYCOL PLUS BISACODYL FOR BOWEL PREPARATION FOR SCREENING COLONOSCOPY: A RANDOMIZED NON INFERIORITY CLINICAL TRIAL
Authors: G de Nucci, P Andreozzi, R Reati, D Morganti, D Redaelli, E Domenico Mandelli, I Arena, M Devani, B Omazzi, C Bezzio, S Saibeni, G Manes
Journal: Endoscopy (2018)

Bowel cleansing has a critical role to increase quality and effectiveness of colonoscopy. International guidelines recommend the use of split dose regimens of PEG solutions. The adoption of split dose regimens in clinical practice remains sub-optimal, in particular in early morning.
FACTORS INFLUENCING THE MISSED DIAGNOSIS OF EARLY GASTRIC CANCER OR HIGH-GRADE DYSPLASIA
Authors: M Agapov, K Khalin, L Zvereva
Journal: Endoscopy (2018)

Endoscopy plays very important role in the diagnosis of gastric cancer. Unfortunately, early gastric cancer and HGD are often associated with subtle mucosal changes and can be easily overlooked. The aim of the current study was to determine the procedure and physician-related factors that influence the missed diagnosis of early gastric cancer or HGD.
Erratum: Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure due to ischemic versus dilated cardiomyopathy (Circulation Research (1992) 71 (18-26))
Authors: A. M. Brillantes, P. Allen, T. Takahashi, S. Izumo, A. R. Marks
Journal: Circulation Research (1992)
CONVERSION FACTOR FOR PREDICTING ADENOMA DETECTION RATE FROM POLYP DETECTION RATE VARY ACCORDING TO COLONOSCOPY INDICATION AND GENDER OF ENDOSCOPED INDIVIDUALS
Authors: G Vojtechova, S Suchanek, O Ngo, B Buckova, T Grega, M Voska, O Majek, M Zavoral
Journal: Endoscopy (2018)

Adenoma detection rate (ADR) is the primary quality indicator for colonoscopy; however, it is difficult to obtain in terms of time and personnel. Polyp detection rate (PDR) is an alternative indicator easily evaluated from administrative data. The main aim of the study was to assess whether PDR and ADR are correlated and to determine the conversion factor to predict ADR from PDR in preventive (screening and FOBT+) colonoscopies.
Nanomedicine Approaches Against Parasitic Worm Infections
Authors: Pengyang Li, Pamela E. Rios Coronado, Xóchitl R. R. Longstaff, Alexander J. Tarashansky, Bo Wang
Journal: Advanced Healthcare Materials (2018)

Abstract Nanomedicine approaches have the potential to transform the battle against parasitic worm (helminth) infections, a major global health scourge from which billions are currently suffering. It is anticipated that the intersection of two currently disparate fields, nanomedicine and helminth biology, will constitute a new frontier in science and technology. This progress report surveys current innovations in these research fields and discusses research opportunities. In particular, the focus is on: (1) major challenges that helminth infections impose on mankind; (2) key aspects of helminth biology that inform future research directions; (3) efforts to construct nanodelivery platforms to target drugs and genes to helminths hidden in their hosts; (4) attempts in applying nanotechnology to enable vaccination against helminth infections; (5) outlooks in utilizing nanoparticles to enhance immunomodulatory activities of worm‐derived factors to cure allergy and autoimmune diseases. In each section, achievements are summarized, limitations are explored, and future directions are assessed.
BLI (BLUE LIGHT IMAGING)™ SYSTEM FOR REAL-TIME HISTOLOGY PREDICTION OF SUBCENTIMETRIC COLORECTAL POLYPS
Authors: E Rondonotti, S Paggi, A Amato, G Mogavero, A Andrealli, G Apinzi, F Radaelli
Journal: Endoscopy (2018)

The study aim was to compare the accuracy of BLI (Blue light imaging™) system using the NICE (Narrow-band Imaging International Colorectal Endoscopic) classification, with high-definition white light (HDWL) in the histology prediction of subcentimetric colonic polyps.
TRANSGASTRIC SUBMUCOSAL TUNNELING ENDOSCOPIC MYOTOMY
Authors: OV Hernández Mondragón, JM Blancas Valencia, MA Barragán Valarezo, OM Solórzano Pineda
Journal: Endoscopy (2018)

We present the case of a 80 year old male who presented with previous diagnosis of achalasia type I in 2015. He responded to esophageal dilation program, but early 2017 he presented again with dysphagia, nausea, vomiting, weight loss.
A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53
Authors: Chao Mao, Xiang Wang, Yating Liu, Min Wang, Bin Yan, Yiqun Jiang, Ying Shi, Yi Shen, Xiaoli Liu, Weiwei Lai, Rui Yang, Desheng Xiao, Yan Cheng, Shuang Liu, Hu Zhou, Ya Cao, Weishi Yu, Kathrin Muegge, Herbert Yu, Yongguang Tao
Journal: Cancer Research (2018)

Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that the cytosolic lncRNA P53RRA is downregulated in cancers and functions as a tumor suppressor by inhibiting cancer progression. Chromatin remodeling proteins LSH and Cfp1 silenced or increased P53RRA expression, respectively. P53RRA bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 1 and 871 of P53RRA and the RRM interaction domain of G3BP1 (aa 177-466). The cytosolic P53RRA-G3BP1 interaction displaced p53 from a G3BP1 complex, resulting in greater p53 retention in the nucleus, which led to cell-cycle arrest, apoptosis, and ferroptosis. P53RRA promoted ferroptosis and apoptosis by affecting transcription of several metabolic genes. Low P53RRA expression significantly correlated with poor survival in patients with breast and lung cancers harboring wild-type p53. These data show that lncRNAs can directly interact with the functional domain of signaling proteins in the cytoplasm, thus regulating p53 modulators to suppress cancer progression.
Accuracy of endoscopic ultrasound in the diagnosis of pancreas divisum in a busy clinical setting
Authors: R Vaughan, I Mainie, B Hoffman, R Hawes, J Romagnuolo
Journal: Endoscopy (2006)

Background: ERCP is of the gold standard for identifying pancreas divisum (PD), however it is associated with a small risk of procedure-related pancreatitis. EUS is capable of tracing the course of the pancreatic ductal system and may have a role in the diagnosis of PD without such procedure related complications.