tbuckley/cabot-search huggingface dataset:
Assessing Factors Associated With Suicide Risk
Authors: Adam Francis Julian Rossiter, Prasanthi Sivakumaran
Journal: JAMA Psychiatry (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
PP04. UTILITY OF DTI AND WHITE FIBRE ANATOMY IN BRAIN TUMOUR SURGERY. A SINGLE CENTRE EXPERIENCE
Authors: Dr Ruichong Ma, Dr Natalie Voets, Mr Vasileios Apostolopoulos, Mr Richard Stacey, Mr Puneet Plaha
Journal: Neuro-Oncology (2017)

INTRODUCTION: Diffusion Tensor Imaging (DTI) is increasingly being utilised as an adjunct in the surgical management of intrinsic brain tumours. Whereas conventional Magnetic Resonance Imaging (MRI) techniques provide only anatomical information, DTI offers data on functional networks by enabling visualization of important white matter tracts in the brain. Importantly, DTI allows neurosurgeons to better guide their surgical approach and resection. Here, the authors illustrate, through various case examples, the various uses for DTI in surgical management of brain tumours. We have performed 131 preoperative MRI+DTI scans between 01/08/2014 and 30/03/2016. PREOPERATIVE SURGICAL PLANNING: DTI provides a visual representation white matter tracts superimposed on to a preoperative MRI in order to better plan operative trajectory in order to minimise the risk of neurological deficit. We provide case examples where the biopsy trajectory has changed after the addition of DTI to the preoperative planning MRI. In addition, we illustrate two cases of deep thalamic tumours which were resected endoscopically. The preoperative DTI imaging helped to plan the resection trajectory through the inferior temporal gyrus in order to avoid damage to the inferior longitudinal fasciculus, corticospinal tracts and corpus callosum. Both patients made a good recovery with postoperative MRI showing complete resection of an otherwise inoperable tumour. We finally illustrate a third where a thalamic tumour was deemed inoperable following review with DTI imaging. Intraoperative Guidance In addition to providing preoperative information to help surgical planning, DTI is also useful intraoperatively. Here we illustrate various cases where DTI has been used intraoperatively, along with cortical stimulation in order to guide the extent of resection in tumours that are close to eloquent areas. The preoperative DTI firstly provides information to the surgeon to decide if awake surgery is required and secondly, along with cortical stimulation, provides visual cues to guide the extent of resection. SUMMARY: Defining functional networks has changed the way we approach the brain tumour surgery. It allows the surgeon to have more meaningful discussion with patients about risks and benefits of surgery, provides information to help plan both whether the surgery should be done awake and the surgical trajectory to take. This has allowed for previously inoperable tumours to be resected without deficit but also helps define truly inoperable tumours. We highly recommend that DTI be used as part of the preoperative assessment of all intraaxial brain tumours.
Achieving Universal Coverage Without Turning to a Single Payer
Authors: Regina E. Herzlinger, Barak D. Richman, Richard J. Boxer
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Variant Philadelphia-Positive Chronic Myeloid Leukemia, der(9) Deletions and Response to Imatinib Mesylate: A Retrospective Multicentric Analysis from the French Fi-LMC Group.
Authors: S. Corm, Franck Nicolini, S. Richebourg, F. Huguet, D. Rea, I. Tigaud, N. Dastugue, S. Raynaud, L. Legros, J. van den Akker, F.X. Mahon, F. Maloisel, C. Roche-Lestienne, A. Guerci, C. Preudhomme, V. Eclache
Journal: Blood (2006)
Abstract A24: ZAP-70 and SYK regulation in the B cell receptor pathway in chronic lymphocytic leukemia
Authors: Maria P. Frushicheva
Journal: Cancer Research (2017)

Abstract Recent discoveries of inhibitors for Syk (spleen tyrosine kinase) family protein kinases provide promising therapeutic options for patients with chronic lymphocytic leukemia (CLL). However, molecular mechanisms of these inhibitors in the B cell receptor (BCR) signaling pathway are not well understood. This study investigates functionality of Syk family protein kinases and their inhibitors in the BCR signaling pathway in CLL cells. In this work, we tested several computational models of ZAP-70 (ζ chain–associated protein kinase of 70 kD) and SYK regulation in the BCR signaling pathway to explain the observed differences in the clinical behaviors of ZAP-70+ / ZAP-70- phenotypes of CLL patients. Specifically, we characterized the effects of different ZAP-70 and SYK expression and phosphorylation levels on the BCR activation threshold. Using stochastic simulations of BCR signaling network, we reproduced the correlations between the observed and calculated trends quantitatively. We find that an increased ZAP-70 expression is correlated with decreased levels of phosphorylated ZAP-70 and SYK, depending on the amount of SYK that is expressed in cells. Our calculations also show that ZAP-70 is able to compensate for a missing SYK functionality with an increased BCR activation threshold in SYK-deficient B-CLL cells, similar to SYK-deficient B cells. Furthermore, our computational model predicts a dual inhibition of ZAP-70 and SYK for the treatment of ZAP-70+ patients, as a selective inhibition of either ZAP-70 or SYK results in disease relapse. Our findings uncover molecular mechanisms of ZAP-70 and SYK regulation in the BCR signaling pathway for the development of CLL immunotherapies. Citation Format: Maria P. Frushicheva. ZAP-70 and SYK regulation in the B cell receptor pathway in chronic lymphocytic leukemia. [abstract]. In: Proceedings of the AACR Special Conference on Engineering and Physical Sciences in Oncology; 2016 Jun 25-28; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2017;77(2 Suppl):Abstract nr A24.
Increasing the Use of Lithium and Clozapine in US Suicide Prevention—Reply
Authors: Michael F. Hogan
Journal: JAMA Psychiatry (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Pre-Screening for Low Methyl Guanine Methyltransferase (MGMT) Expression Results in High Response Rates to Temozolomide (TMZ) Therapy in AML and MDS Patients.
Authors: Joseph Brandwein, Jeannine Kassis, Brian Leber, Kang Howson-Jan, Mark D. Minden, Andre Galarneau, Jean-Francois Pouliot
Journal: Blood (2011)
Combined Fludarabine, Cyclophosphamide, and Alemtuzumab (FCC), an Active Regimen for Treated Patients with Chronic Lymphocytic Leukemia (CLL).
Authors: Marco Montillo, Sara Miqueleiz, Alessandra Tedeschi, Francesca Ricci, Eleonora Vismara, Denis Ciapanna, Valeria Belsito Petrizzi, Monica Crugnola, Mauro Spriano, Lilj Uziel, Angelo De Blasio, Pierangelo Spedini, Enrica Morra
Journal: Blood (2007)
Severity of Hypoxemia and Effect of High-Frequency Oscillatory Ventilation in Acute Respiratory Distress Syndrome
Authors: Maureen O. Meade, Duncan Young, Steven Hanna, Qi Zhou, Thomas E. Bachman, Casper Bollen, Arthur S. Slutsky, Sarah E. Lamb, Neill K. J. Adhikari, Spyros D. Mentzelopoulos, Deborah J. Cook, Sachin Sud, Roy G. Brower, B. Taylor Thompson, Sanjoy Shah, Alex Stenzler, Gordon Guyatt, Niall D. Ferguson
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Rationale: High-frequency oscillatory ventilation (HFOV) is theoretically beneficial for lung protection, but the results of clinical trials are inconsistent, with study-level meta-analyses suggesting no significant effect on mortality.Objectives: The aim of this individual patient data meta-analysis was to identify acute respiratory distress syndrome (ARDS) patient subgroups with differential outcomes from HFOV.Methods: After a comprehensive search for trials, two reviewers independently identified randomized trials comparing HFOV with conventional ventilation for adults with ARDS. Prespecified effect modifiers were tested using multivariable hierarchical logistic regression models, adjusting for important prognostic factors and clustering effects.Measurements and Main Results: Data from 1,552 patients in four trials were analyzed, applying uniform definitions for study variables and outcomes. Patients had a mean baseline PaO2/FiO2 of 114 ± 39 mm Hg; 40% had severe ARDS (PaO2/FiO2 <100 mm Hg). Mortality at 30 days was 321 of 785 (40.9%) for HFOV patients versus 288 of 767 (37.6%) for control subjects (adjusted odds ratio, 1.17; 95% confidence interval, 0.94–1.46; P = 0.16). This treatment effect varied, however, depending on baseline severity of hypoxemia (P = 0.0003), with harm increasing with PaO2/FiO2 among patients with mild-moderate ARDS, and the possibility of decreased mortality in patients with very severe ARDS. Compliance and body mass index did not modify the treatment effect. HFOV increased barotrauma risk compared with conventional ventilation (adjusted odds ratio, 1.75; 95% confidence interval, 1.04–2.96; P = 0.04).Conclusions: HFOV increases mortality for most patients with ARDS but may improve survival among patients with severe hypoxemia on conventional mechanical ventilation.
Clinical characteristics and predictors of mortality in cirrhotic patients with candidemia and intra-abdominal candidiasis: a multicenter study
Authors: Matteo Bassetti, Maddalena Peghin, Alessia Carnelutti, Elda Righi, Maria Merelli, Filippo Ansaldi, Cecilia Trucchi, Cristiano Alicino, Assunta Sartor, Pierluigi Toniutto, Joost Wauters, Wim Laleman, Carlo Tascini, Francesco Menichetti, Roberto Luzzati, Pierluigi Brugnaro, Alessio Mesini, Stefania Raviolo, Francesco G. De Rosa, Leonel Lagunes, Jordi Rello, George Dimopoulos, Arnaldo L. Colombo, Marcio Nucci, Antonio Vena, Emilio Bouza, Patricia Muñoz, Mario Tumbarello, Raffaella Losito, Ignacio Martin-Loeches, Claudio Viscoli
Journal: Intensive Care Medicine (2017)
Red Blood Cell Deformability, Age, Ethnicity and Susceptibility to Malaria in Africa
Authors: Benoît Henry, Camille Roussel, Papa Alioune Ndour, Mario Carucci, Julien Duez, Aurélie Fricot, Florentin Aussenac, Hilaire Akpovi, David Courtin, Jérôme Clain, Yves Colin Aronovicz, André Garcia, Audrey Sabbagh, Pierre A Buffet
Journal: Blood (2016)
A Novel Strategy for Combining Immunotherapy with High Dose Chemotherapy and Auto-Transplantation in High Risk Multiple Myeloma.
Authors: Susann Szmania, Michele Cottler-Fox, Nancy Rosen, Sanjaya Viswamitra, Amberly Moreno, Mindy Pomtree, Bart Barlogie, Guido Tricot, Frits van Rhee
Journal: Blood (2004)
Abstract P4-12-15: Triple-negative breast cancers (TNBCs) rich in infiltrating stromal plasma cells have improved disease-free survival and overall survival
Authors: PJ McIntire, X Cui, PS Ginter, L Irshaid, Z Chen, SJ Shin
Journal: Cancer Research (2017)

Abstract Background Tumor-infiltrating lymphocytes (TILs) have emerged as a prognostic indicator in patients with TNBC. Furthermore, lymphocyte-predominant breast cancer (LPBC), defined as those containing ≥50% stromal TILs has been shown to be associated with better prognosis. While cell-mediated immunity has received much of the credit for anti-tumor responses, the International TILs Working Group recommends that the assessment of stromal density of TILs should incorporate all mononuclear cells including plasma cells. Very little is known about the role of humoral immunity, particularly the role of plasma cells in the anti-tumoral response in breast cancer. We sought to evaluate the prognostic value of plasma cells in the setting of stromal TIL assessment of TNBC. Design Morphologic assessment of TILs was performed on a representative H&amp;E slide of 76 cases of primary TNBC. For each case, the stromal density of TILs was estimated and then classified as LPBC or non-LPBC using a cutoff of ≥50% for the former. Also, the plasma cell intensity defined as the mean percentage of stromal plasma cells of five 40x high power microscopic fields of TILs was recorded at 5% increments. Statistical analyses were performed using disease-free survival (DFS) and overall survival (OS) (range: 16 to 196 months, mean: 110 months) as primary endpoints. Results Plasma cell intensity was dichotomized at 12.5% and predictive of OS [.21, 95% confidence interval (CI) .05-.93, P = 0.0401)]. A positive dose related response trended toward significance for each 5% increase in plasma cell intensity (.97, 95% CI .93-1.01, P = 0.1168). Disease-free survival also trended positively towards significance (.39, 95% CI .13-1.20, P = 0.0991). When comparing LPBC, tumors rich in plasma cells (&amp;gt;12.5% of TILs) trended towards longer DFS (.17, 95% CI .02-1.62, P = 0.1226) when compared to plasma cell poor LPBC. Conclusion In addition to the cell-mediated immune response in TNBC, our findings suggest that humoral immunity may also play a role in predicting recurrence and survival in these patients. Our findings suggest that inclusion of an additional parameter of plasma cell intensity may be prognostically valuable in TIL assessment of TNBC. Citation Format: McIntire PJ, Cui X, Ginter PS, Irshaid L, Chen Z, Shin SJ. Triple-negative breast cancers (TNBCs) rich in infiltrating stromal plasma cells have improved disease-free survival and overall survival [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P4-12-15.
Is Excessive Resource Utilization an Adverse Event?
Authors: Josué A. Zapata, Andrew R. Lai, Christopher Moriates
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of Brugada ECG Pattern in Thailand From a Population-Based Cohort Study
Authors: Pattara Rattanawong, Tachapong Ngarmukos, Eugene H. Chung, Wasawat Vutthikraivit, Prapaipan Putthapiban, Weera Sukhumthammarat, Prin Vathesatogkit, Piyamitr Sritara
Journal: Journal of the American College of Cardiology (2017)
Abstract P272: Relationship of Potato Consumption, Total and by Preparation Method With Blood Pressure and Body Mass Index: The International Population Study on Macronutrients and Blood Pressure (INTERMAP) US Study
Authors: Kamalita Pertiwi, Linda M Oude Griep, Jeremiah Stamler, Queenie Chan, Johanna M Geleijnse, Lyn M Steffen, Beatriz Rodriguez, Martha L Daviglus, Linda Van Horn, Paul Elliott
Journal: Circulation (2017)

Background: Limited evidence from prospective US cohort studies suggests that higher potato intake is associated with a higher risk of hypertension and obesity. Different preparation methods affect the nutritional composition of potatoes and are related to different dietary choices that may influence associations with blood pressure and body mass index (BMI). Objective: To investigate potato consumption, total and by preparation method, in relation to blood pressure and BMI. Methods: We used cross-sectional data of 2,195 participants aged 40 to 59 in 1996-1997 from the United States samples of the population-based INTERMAP study. During four visits, four in-depth multipass 24-hour dietary recalls and eight blood pressure measurements were collected. Reported potato intakes were categorized as fried and non-fried potatoes, using the USDA food grouping system. Potato intakes (g/1000 kcal) were averaged over four days. Regression coefficients per 2SD higher intake were estimated using multivariate linear regression analyses with adjustments for age, sex, sample, lifestyle and disease factors, and other food groups. To assess influence on the association, diet quality (by Dietary Approaches to Stop Hypertension adherence score), BMI, urinary sodium and potassium were added separately to the previous model. Results: Median intake of total, non-fried, and fried potatoes were 40 g/d, 23 g/d and 8 g/d, respectively. Total and non-fried potato intakes were not associated with blood pressure. The association between fried potatoes and blood pressure varied by sex (P for interaction=0.03). In women, higher fried potato intake (2SD: 20 g/1000 kcal) was associated with a +3.00 mmHg (95%CI: 1.29, 4.71) higher systolic and +1.26 mmHg (95%CI: 0.15, 2.38) higher diastolic blood pressure, which prevailed after additional, but separate, adjustments for BMI, diet quality, urinary sodium and potassium. Potato chips contributed predominantly (79%) to fried potato intake and accounted for the direct association of fried potatoes and blood pressure (+3.77 mmHg systolic (95%CI: 1.92, 5.62), and +1.80 mmHg diastolic (95%CI: 0.62, 2.98)). The association between fried potatoes and blood pressure was not found in men. In the total population, higher fried potato intake was positively associated with BMI (+0.62, 95%CI: 0.14, 1.09) but attenuated after adjustment for diet quality. Total and non-fried potatoes were not associated with BMI. Conclusions: In contrast to non-fried potato intake, fried potato consumption was directly related to blood pressure in women. This finding is in line with results of previous US cohort studies and suggests that the association of potatoes with blood pressure may depend on preparation method.
Retreatment with brentuximab vedotin in CD30‑positive hematologic malignancies: A phase II study.
Authors: Nancy Bartlett, Pauline Brice, Robert W. Chen, Michelle A. Fanale, Ajay K. Gopal, Jeffrey Matous, Joseph David Rosenblatt, Laurie E. Grove, Andres Forero-Torres
Journal: Journal of Clinical Oncology (2012)

8027 Background: Brentuximab vedotin comprises an anti-CD30 antibody conjugated by a protease-cleavable linker to a microtubule-disrupting agent, MMAE. In pivotal phase 2 studies in patients (pts) with relapsed/refractory Hodgkin lymphoma (HL) or systemic anaplastic large cell lymphoma (sALCL), objective response rates were 75% and 86% and median durations of response were 6.7 and 12.6 mo, respectively. A phase 2 study was initiated to investigate if pts who have previously responded to brentuximab vedotin could achieve another remission with retreatment (ClinicalTrials.gov #NCT00947856). Methods: Pts had a CD30-positive hematologic malignancy, achieved an objective response (per Cheson 2007) with prior brentuximab vedotin treatment, and experienced relapse after discontinuing treatment. Brentuximab vedotin was administered IV 1.8 mg/kg every 21 days; antitumor activity was assessed by the investigator. Results: 14 HL pts and 8 sALCL (5 ALK-negative) pts were enrolled (median age 34 yr, range 16–72). Pts had received a median of 4 prior chemotherapy regimens (range 2–12). Median time since the previous brentuximab vedotin treatment was 6.9 mo (range 1–44). Median number of retreatment cycles was 7 (range 1+ to 32+). Adverse events (AEs) in &gt;25% of pts were nausea (41%), fatigue (36%), peripheral sensory neuropathy (36%), and diarrhea (27%). The most common Grade 3/4 AEs were anemia, fatigue, and hyperglycemia (3 pts each). Of the 11 pts who had pre-existing peripheral neuropathy, 3 (27%) had worsening with retreatment. Best clinical responses in pts with HL were 3 CR, 5 PR, 3 SD, 3 PD. Among pts with sALCL, 5 achieved a CR, 1 had PD, and 2 were not yet evaluated. Of the 8 pts with CR in retreatment, previous best responses to brentuximab vedotin treatment were 4 PR and 4 CR. Median duration of retreatment response was 10.8 mo (range 0+ to 10.8), and in pts who achieved CR, the median duration of response was not reached (range 0+ to 10.5 mo); 11 pts remain on retreatment. Conclusions: Retreatment with brentuximab vedotin was generally well tolerated. Objective responses were observed (13 of 20; 65%) in this heavily pretreated population. Enrollment to the phase 2 retreatment study is ongoing.