tbuckley/cabot-search huggingface dataset:
Abstract 11443: Higher Leptin Levels are Associated With Reduced Left Ventricular Mass and Left Ventricular Diastolic Stiffness in African American Women: Insights From the Genetic Epidemiology Network of Arteriopathy (GENOA) Study
Authors: Daisuke Kamimura, Takeki Suzuki, Wanmei Wang, Matthew D Deshazo, John E Hall, Michael D Winniford, Thomas H Mosley, Kenneth R Butler, Michael E Hall
Journal: Circulation (2016)

Background: Leptin has been associated with left ventricular (LV) hypertrophy and heart failure in some epidemiologic studies while other studies have demonstrated a beneficial effect on cardiac remodeling and function. We hypothesized that leptin may play a role in protecting the heart from developing LV hypertrophy and stiffening. Methods and Results: We evaluated 1172 African Americans with preserved LV ejection fraction (EF &gt;50%) from the Genetic Epidemiology Network of Arteriopathy (GENOA) Study (mean age 62.9 years, 72% women). LV diastolic stiffness was assessed by echocardiography using the diastolic wall strain (DWS) indicator. Associations between leptin levels and indices of LV structure and function were evaluated using generalized estimating equations (GEE) approach with Gaussian distribution accounting for clustering in siblings. All models were adjusted for possible confounders including age, body mass index, systolic blood pressure, blood pressure lowering medication, coronary heart disease, current smoking status and estimated glomerular filtration rate and stratified by sex because leptin levels were three times higher in women than men (p &lt;0.001). After adjustment, higher leptin levels were associated with lower LV mass and less LV diastolic stiffness (p &lt;0.05, for both) in women, while there were no statistically significant associations between leptin levels and LV structure and function in men. In women, there were interactions between leptin levels and body mass index quartiles on LV mass and LV diastolic stiffness (p &lt;0.05, for both). Higher leptin levels were associated with lower LV mass and LV diastolic stiffness more in obese rather than in lean women (Figure). Conclusions: Higher leptin levels were associated with lower LV mass and LV diastolic stiffness in obese African American women. Leptin may play an important role in protecting the heart from developing precursors to heart failure in obese African American women.
Comparison of ethylenediaminetetraacetic acid-treated desmoglein ELISA and conventional desmoglein ELISA in the evaluation of pemphigus vulgaris in remission
Authors: Maryam Daneshpazhooh, Hamidreza Mahmoudi, Kamran Balighi, Amir Teimourpour, Zohreh Khodashenas, Maryam Ghiasi, Hasan Khosravi, Cheyda Chams-Davatchi
Journal: Journal of the American Academy of Dermatology (2018)
Clinical Impact of p27Kip1 and CaSR Expression on Primary Hyperparathyroidism
Authors: Gozde Sengul Aycicek, Berna Imge Aydogan, Mustafa Sahin, Cevriye Cansız Ersoz, Serpil Dizbay Sak, Nilgun Baskal
Journal: Endocrine Pathology (2018)
OMENTAL PATCH FOR CLOSURE OF CAECUM PERFORATION DURING ENDOSCOPIC PIECEMEAL MUCOSAL RESECTION OF GRANULAR-LATERAL SPREADING TUMOR (LST-G) IN ULCERATIVE COLITIS PATIENT (WITH VIDEO)
Authors: F Auriemma, PA Galtieri, R Maselli, S Attardo, EC Ferrara, S Carrara, A Fugazza, A Anderloni, E Troncone, F Furfaro, R Semeraro, A Repici
Journal: Endoscopy (2018)

Colorectal perforation is a rare but severe event related to therapeutic interventions. European guidelines recommend that endoscopic closure should be considered depending on the type of perforation, its size and endoscopist expertise. We report the case of caecum perforation during piecemeal EMR of large granular lateral spreading tumor (LST-G) in ulcerative colitis patients, treated by omental patching.
Abstract 13642: Right Ventricular Strain in Pulmonary Arterial Hypertension: Comparison Between 2D Echocardiography and Cardiovascular Magnetic Resonance
Authors: Benjamin H Freed, Wendy Tsang, Nicole M Bhave, Lynn Weinert, Megan Yamat, Karin Dill, Kirk Spencer, Victor Mor-Avi, Amit R Patel, Mardi Gomberg-Maitland, Roberto M Lang
Journal: Circulation (2012)

Background: Right ventricular (RV) strain is a potentially useful prognostic marker in patients with pulmonary arterial hypertension (PAH). Two-dimensional (2D) speckle-tracking echocardiography (S...
CONSERVATIVE MANAGEMENT OF RARE COMPLICATION OF GAS IN LESSER SAC AFTER EUS GUIDED CYSTOGASTROSTOMY
Authors: V Abishek, M Swaminathan, V Leelakrishnan
Journal: Endoscopy (2018)

Pneumoperitoneum after EUS guided cystogastrostomy is a rare complication presenting as shoulder pain. This is due to gas in lesser sac. This complication was managed conservatively with faster recovery.
Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases
Authors: Md. Saddam Hussain, Vishwas Tripathi
Journal: Military Medical Research (2018)

Autoimmune disease management presents a significant challenge to medical science. Environmental factors potentially increase the risk of developing inflammatory and autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. Among various environmental stresses, cigarette smoke and hypoxia have both been reported to lead to an enhanced risk of inflammatory and autoimmune diseases. In this review, we shed light on all reported mechanisms whereby cigarette smoke and a hypoxic environment can induce inflammatory and autoimmune diseases and discuss how hypoxic conditions influence the cigarette smoke-induced threat of inflammatory and autoimmune disease development. Cigarette smoke and hypoxia both lead to increased oxidative stress and production of reactive oxygen species and other free radicals, which have various effects including the generation of autoreactive pro-inflammatory T cells and autoantibodies, reductions in T regulatory (Treg) cell activity, and enhanced expression of pro-inflammatory mediators [e.g., interleukin-6 (IL-6), interleukin-4 (IL-4) and interleukin-8 (IL-8)]. Accordingly, smoking and hypoxic environments may synergistically act as potent environmental risk factors for inflammatory and autoimmune diseases. To our knowledge, no studies have reported the direct association of cigarette smoke and hypoxic environments with the risk of developing inflammatory and autoimmune diseases. Future studies exploring the risk of autoimmune disease development in smokers at high altitudes, particularly military personnel and mountaineers who are not acclimatized to high-altitude regions, are required to obtain a better understanding of disease risk as well as its management.
Abstract 20890: Change in B-Type Natriuretic Peptide Level Holds Higher Positive Predictive Value Compared to Gene Expression Profiling Test for Cardiac Allograft Rejection
Authors: Arun Damodaran, Todd Dardas, Keith D Aaronson, David B Dyke, Scott L Hummel, Jennifer Cowger, Audrey H Wu, Todd M Koelling
Journal: Circulation (2010)

Introduction:  BNP levels have been shown to be associated with cardiac rejection, but the predictive value of changes in BNP has not been well-defined. The Allomap gene-expression profiling (GEP) test, owing to its high negative predictive value of 98.9% but relatively low positive predictive value of 4% at a score of >=34, has been suggested as a method to rule-out rejection.   Hypothesis:  We assessed the hypothesis that changes in BNP may be equivalent to GEP as a diagnostic test to predict cardiac allograft rejection.   Methods:  BNP and biopsy results were obtained for 205 subjects who underwent 4007 endomyocardial biopsy procedures. Biopsies analyzed were more than 180 days post-transplant (median 506 days, IQR 303 – 924 days), with a previous biopsy of grade  =3A (REJ). We used a repeated measures logistic regression model to assess the association of change in BNP (parameterized categories) with REJ.   Results:  There were 53 episodes of REJ in 1544 biopsies analyzed. Median change in BNP (dBNP) for those with REJ was 13.5 pg/mL (IQR -31 to 121 pg/mL) and among those with grade  =250 pg/mL was associated with REJ (OR 11.0, p  =250 remained a powerful predictor of REJ (OR 10.3, p =250pg/mL for REJ had a positive predictive value (PPV) of 26% (95% CI 18–34%) and negative predictive value (NPV) of 97% (95% CI 96.6–97.4%). We adjusted our prevalence of REJ (3.4%) to that seen in the CARGO study (1.7%), which changed our PPV to 14% (95% CI 8–21%) and NPV to 98.5% (95% CI 98.2–98.8%).   Conclusions:  Change in BNP >=250pg/mL is independently associated with a high risk of Grade >=3A rejection. dBNP  th  the price) compared to the GEP test.
Traitement endoscopique par colle biologique des fistules anastomotiques colo-rectales post-chirurgicales. Résultats à long terme
Authors: JC Valats, P Bauret
Journal: Endoscopy (2009)

Introduction: La chirurgie colo-rectale se complique de fistules dans 5 à 15% des cas selon les séries. L'application de colle biologique par endoscopie a été proposée pour le traitement de ces fistules. Nous rapportons l'expérience de notre centre.
INCIDENCE AND OUTCOMES OF ENDOSCOPIC ESOPHAGEAL VARICEAL LIGATION-INDUCED ULCER BLEEDING
Authors: S Machlab, J da Costa, D Horta, P Ruiz, J Profitós, M Vergara, M Miquel, M Casas, B Dalmau, E Brullet, F Junquera, V Puig-Diví, E Martínez-Bauer, R Campo, P García-Iglesias, J Sánchez-Delgado
Journal: Endoscopy (2018)

Retrospective multicenter study. Patients treated with elective band ligation between January 2013 and December 2015 in three centers were included and each treatment session was analyzed. Clinical, endoscopic and analytical variables were collected.
BILIARY CAST SYNDROME AFTER OLT: A SINGLE-CENTRE CASE SERIES AND LITERATURE REVIEW
Authors: M Cintolo, A Tringali, E Forti, L De Carlis, L Belli, A De Gasperi, L Dioscoridi, C Laura, G Bonato, M Mutignani
Journal: Endoscopy (2018)

No clear data are available about long-term outcomes after endotherapy for Biliary Cast Syndrome (BCS) after OLT
Clinical utility of colon cancer molecular subtypes: Validation of two main colorectal molecular classifications on the PETACC-8 phase III trial cohort.
Authors: Laetitia Marisa, Mira Ayadi, Ralyath Balogoun, Camilla Pilati, Karine Le Malicot, Come Lepage, Jean-François Emile, Ramon Salazar, Daniela Ellen Aust, Alex Duval, Janick Selves, Dominique Esperance Guenot, Gerard A. Milano, Jean-François Seitz, Julien Taieb, Valerie Boige, Aurelien De Reynies, Pierre Laurent-Puig
Journal: Journal of Clinical Oncology (2017)

3509 Background: The molecular subtyping of colon cancers (CC) has been the subject of several recent publications, leading to an international consensus. The clinical relevance of these molecular classifications remains to be evaluated on large prospective patient cohorts using a tool that can be widely used on formalin-fixed paraffin-embedded (FFPE) samples. Methods: We aimed to evaluate the clinical relevance of two molecular subtyping systems, CMS (Guinney et al. 2015) and CCMST (Marisa et al. 2013), on the PETACC-8 cohort, a randomized phase III trial comparing adjuvant FOLFOX with or without cetuximab in patients with stage III CC. For each of these two classification systems, a predictor tool was developed and adapted to FFPE samples. The NanoString nCounter platform was used to screen 196 genes. Predictors were built from 249 frozen tumor samples previously used to build our classification system and 61 new paired FFPE/frozen samples. Both predictors were then applied to 1781 PETACC-8 FFPE samples. Subtypes associations to clinical and molecular features were analyzed. Results: The CMS predictor assigned 297 samples to CMS1 (17%), 585 to CMS2 (34%), 68 to CMS3 (4%) and 770 to CMS4 (45%). CMS were significantly associated with several molecular and clinical features, including MSI status (49% in CMS1, p &lt; 0.001), CIMP status (47% in CMS1, p &lt; 0.001), KRAS mutation (75% in CMS3, p &lt; 0.001), BRAF mutation (34% in CMS1, p &lt; 0.001), tumor location (less proximal tumors in CMS2, p &lt; 0.001), validating the predictor tool developed. The classification was significantly associated to prognosis in multivariate analysis, CMS4 subtype having a shorter overall survival (hazard ratio = 1.7, p= 0.021). A deleterious effect of cetuximab was observed in CMS1 (p &lt; 0.05). Similar results were obtained with the CCMST classification. Conclusions: We validated molecular CC subtyping predictors for both CMS and CCMST classifications on PETACC-8 FFPE samples. The prognostic value of CMS and CCMST classifications was confirmed, stem-like tumors being associated with a poor prognosis. These results pave the avenue for widely use of the CC molecular classification in clinical routine.
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations
Authors: Jun Gong, Alexander Chehrazi-Raffle, Srikanth Reddi, Ravi Salgia
Journal: Journal for ImmunoTherapy of Cancer (2018)

Early preclinical evidence provided the rationale for programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) blockade as a potential form of cancer immunotherapy given that activation of the PD-1/PD-L1 axis putatively served as a mechanism for tumor evasion of host tumor antigen-specific T-cell immunity. Early-phase studies investigating several humanized monoclonal IgG4 antibodies targeting PD-1 and PD-L1 in advanced solid tumors paved way for the development of the first PD-1 inhibitors, nivolumab and pembrolizumab, approved by the Food and Drug Administration (FDA) in 2014. The number of FDA-approved agents of this class is rapidly enlarging with indications for treatment spanning across a spectrum of malignancies. The purpose of this review is to highlight the clinical development of PD-1 and PD-L1 inhibitors in cancer therapy to date. In particular, we focus on detailing the registration trials that have led to FDA-approved indications of anti-PD-1 and anti-PD-L1 therapies in cancer. As the number of PD-1/PD-L1 inhibitors continues to grow, predictive biomarkers, mechanisms of resistance, hyperprogressors, treatment duration and treatment beyond progression, immune-related toxicities, and clinical trial design are key concepts in need of further consideration to optimize the anticancer potential of this class of immunotherapy.
Assessment of training needs and development of a simulation based training programme for semi-automated robotic colonoscopy
Authors: M. Kopczynska, S. Smits, R. Hopps, N. Warren, S. Goddard, X. Ye, S. Dolwani
Journal: Gut (2017)

Early diagnosis of colorectal cancer results in better patient outcomes. Reported barriers to screening amongst non-responders, delays in diagnostic pathways, and current constraints in colonoscopy capacity contribute to delays in diagnosis. We hypothesise that changing the diagnostic paradigm through primary care based semi-automated robotic colonoscopy may improve access and engagement. This project involved development of a training programme with a simulation training model to understand the specific training needs and methods of fulfilling these for the potential ultimate users of primary care based robotic colonoscopy.
Questions About a Clinical Trial Evaluating the Addition of Cetuximab to Definitive Chemoradiation Therapy With Paclitaxel and Cisplatin for Patients With Esophageal Cancer
Authors: Antoine Adenis, Florian Lordick
Journal: JAMA Oncology (2018)

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CAN ENDOSCOPIC ULTRASOUND (EUS) BE USEFUL IN THE STUDY OF AMPULLARY LESIONES (AL)? CASE-SERIE STUDY OF 33 PATIENTS
Authors: M Rodríguez Carrasco, C Cuadrado Tiemblo, M Pérez Carreras, M Algara San Nicolás, JC Marín Gabriel, A Del Pozo García, A Pérez Barrios, JB Díaz Tasende, A Pérez Campos, G Castellano Tortajada
Journal: Endoscopy (2018)

Imaging evaluation of ampullary region poses a diagnostic challenge due to its high complex anatomy, specially in the differential diagnosis of benign/malignant AL. Owing to its high-spatial-resolution images, EUS is proposed as the most accurate technique for this purpose. The aim of this study was: 1. To evaluate the indications and overall diagnostic accuracy of EUS ± guided fine needle aspiration (FNA) on the evaluation of AL; 2. To compare EUS-FNA diagnostic accuracy with cytological brushing/histological biopsy.
A POPULATION BASED STUDY OF INTRAMUCOSAL (TIS) COLORECTAL CARCINOMAS DIAGNOSED BETWEEN 2009 AND 2013
Authors: J Briant, M Cariou, F Cholet, A Billot-Grasset, L Doucet, JB Nousbaum, M Robaszkiewicz
Journal: Endoscopy (2018)

The aim of our study was to analyze clinico-pathological characteristics and management of all Tis colorectal adenocarcinomas diagnosed in a population based study between 2009 and 2013.
Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength
Authors: Kevin W. Kelley, Lucile Ben Haim, Lucas Schirmer, Giulia E. Tyzack, Michaela Tolman, John G. Miller, Hui-Hsin Tsai, Sandra M. Chang, Anna V. Molofsky, Yongjie Yang, Rickie Patani, Andras Lakatos, Erik M. Ullian, David H. Rowitch
Journal: Neuron (2018)

Diversified neurons are essential for sensorimotor function, but whether astrocytes become specialized to optimize circuit performance remains unclear. Large fast α-motor neurons (FαMNs) of spinal cord innervate fast-twitch muscles that generate peak strength. We report that ventral horn astrocytes express the inward-rectifying K+ channel Kir4.1 (a.k.a. Kcnj10) around MNs in a VGLUT1-dependent manner. Loss of astrocyte-encoded Kir4.1 selectively altered FαMN size and function and led to reduced peak strength. Overexpression of Kir4.1 in astrocytes was sufficient to increase MN size through activation of the PI3K/mTOR/pS6 pathway. Kir4.1 was downregulated cell autonomously in astrocytes derived from amyotrophic lateral sclerosis (ALS) patients with SOD1 mutation. However, astrocyte Kir4.1 was dispensable for FαMN survival even in the mutant SOD1 background. These findings show that astrocyte Kir4.1 is essential for maintenance of peak strength and suggest that Kir4.1 downregulation might uncouple symptoms of muscle weakness from MN cell death in diseases like ALS.
Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline
Authors: Jeanin van Hooft, Emo van Halsema, Geoffroy Vanbiervliet, Regina Beets-Tan, John DeWitt, Fergal Donnellan, Jean-Marc Dumonceau, Robert Glynne-Jones, Cesare Hassan, Javier Jiménez-Perez, Søren Meisner, V. Muthusamy, Michael Parker, Jean-Marc Regimbeau, Charles Sabbagh, Jayesh Sagar, Pieter Tanis, Jo Vandervoort, George Webster, Gianpiero Manes, Marc Barthet, Alessandro Repici
Journal: Endoscopy (2014)

This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). This Guideline was also reviewed and endorsed by the Governing Board of the American Society for Gastrointestinal Endoscopy (ASGE). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was adopted to define the strength of recommendations and the quality of evidence. <b>Main recommendations</b> The following recommendations should only be applied after a thorough diagnostic evaluation including a contrast-enhanced computed tomography (CT) scan. <b>1</b> Prophylactic colonic stent placement is not recommended. Colonic stenting should be reserved for patients with clinical symptoms and imaging evidence of malignant large-bowel obstruction, without signs of perforation (strong recommendation, low quality evidence). <b>2</b> Colonic self-expandable metal stent (SEMS) placement as a bridge to elective surgery is not recommended as a standard treatment of symptomatic left-sided malignant colonic obstruction (strong recommendation, high quality evidence). <b>3</b> For patients with potentially curable but obstructing left-sided colonic cancer, stent placement may be considered as an alternative to emergency surgery in those who have an increased risk of postoperative mortality, i. e. American Society of Anesthesiologists (ASA) Physical Status ≥ III and/or age > 70 years (weak recommendation, low quality evidence). <b>4</b> SEMS placement is recommended as the preferred treatment for palliation of malignant colonic obstruction (strong recommendation, high quality evidence), except in patients treated or considered for treatment with antiangiogenic drugs (e. g. bevacizumab) (strong recommendation, low quality evidence).
ENDOSCOPIC MANAGEMENT OF COLONIC INTUSSUSCEPTION BY ESD- CASE SERIES
Authors: S Kumar Korrapati, M Mahadik, P Nemade, J Bapaye, A Bapaye
Journal: Endoscopy (2018)

Intussusception is telescoping of one bowel segment into another. Intussusception is rare in adults1. Colonic involvement represents up to 50% of cases2. Due to the high rates of malignancy and recurrence in adult intussusception, it has traditionally been considered an indication for surgery. We report our single center experience in management of adult colonic intussusception by Endoscopic Submucosal Dissection (ESD).
Péritonéoscopie par voie transvaginale: A propos d'un cas
Authors: E Bories, E Lambaudi, M Bannier, F Caillol, C Pesenti, S Cambon, D Francon, M Giovannini, G Houvenaeghel
Journal: Endoscopy (2009)

Introduction: La Chirurgie Endoscopique Transluminale par les voies naturelles (NOTES) est une nouvelle conception de chirurgie mini-invasive couplant les techniques de coelioscopie et d'endoscopie interventionnelle. Cette nouvelle technique ouvre la possibilité de réaliser des laparoscopies sans incision cutanée évitant ainsi les greffes néoplasiques des orifices de trocart et les cicatrices cutanées, surtout pour des patients ayant un mauvais pronostic. Nous rapportons ici notre première expérience de laparoscopie par voie transvaginale.
TRANSORAL OUTLET REDUCTION (TORE) BY ENDOSCOPIC SUTURING IN PATIENTS WITH WEIGHT REGAIN AFTER ROUX-EN-Y GASTRIC BYPASS. PRELIMINARY OUTCOMES OF FEASIBILITY, EFFICACY AND SAFETY
Authors: S Bacchiddu, E Espinet Coll, J Nebreda Duran, G López-Nava Breviere, M Galvao-Neto, P Diaz Galan, JA Gómez Valero, C Vila Lolo, I Bautista-Castaño, A Juan-Creix Comamala
Journal: Endoscopy (2018)

The aim of this study was to evaluate the technical feasibility, and safety and efficacy outcomes, in the short-medium term, of transoral outlet reduction (TORe), by means of an endoscopic suture device in patients with weight regain after Roux-en-Y gastric bypass (RYGB).
THE CLINICOPATHOLOGICAL FEATURES OF GASTRIC NEOPLASMS IN PATIENTS WITH FAP
Authors: K Nakano, A Chino, M Arai, H Kawachi, A Ishiyama, S Saito, J Fujisaki
Journal: Endoscopy (2018)

In familial adenomatous polyposis (FAP), fundic gland polyp (FGP), adenoma and adenocarcinoma (AC) are recognized as extracolonic manifestations in the stomach. Despite the lack of concrete evidence, Helicobacter pylori infection is believed to affect gastric neoplasm development in FAP. Here, we examined the clinicopathological features of gastric neoplasms in patients with FAP.