tbuckley/cabot-search huggingface dataset:
Aryl Hydrocarbon Receptor (AhR) Pathway Directly Controls Hematopoietic Proliferation in Chronic Myeloid Leukemia (CML) and Its Inhibition Allows Massive Expansion of Leukemic Progenitors and Stem Cells
Authors: Melanie Gentil, Patricia Hugues, Gladys Telliam, Ivan Sloma, Seda Baykal, Jerome Artus, Agnes Guerci, Hyacinthe Johnson Ansa, Adlen Foudi, Annelise Bennaceur-Griscelli, Ali G Turhan
Journal: Blood (2015)
Single Nucleotide Polymorphism (SNP) Discovery within the UGT1A Gene Complex: Allelic Frequencies and Ethnic Differences.
Authors: Jeeranut Sawattep, Thad A. Howard, Noppawan P. Morales, Yupin Sanvarinda, Pranee Fucharoen, Suthat Fucharoen, Russell E. Ware
Journal: Blood (2004)
Proteomics–Based Approach Predicts Molecular Response and Stratifies Responders to Tyrosine Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) Patients
Authors: Ayodele Alaiya, Naeem A. Chaudhri, Hafiz Malhan, Tarek Owaidah, Zakia Shinwari, Jonathan Fox, Fahad Alsharif, Said Mohamed, Walid Rasheed, Osman Ahmed Syed, Mahmoud D. Aljurf
Journal: Blood (2014)
Pooled Analysis of Elderly Patients with Newly Diagnosed AML Treated with Sapacitabine and Decitabine Administered in Alternating Cycles.
Authors: Farhad Ravandi, Tapan M. Kadia, Gautam Borthakur, William G. Wierda, Stuart L. Goldberg, Meir Wetzler, Parameswaran Venugopal, Karen Seiter, Judy Chiao, Hagop M. Kantarjian
Journal: Blood (2012)
Public-Private Partnership Speeds Investigator Access to Cancer Drugs
Authors: Jennifer Abbasi
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcomes after Initial Relapse of Multiple Myeloma: An International Myeloma Working Group Study
Authors: Shaji K Kumar, Jae Hoon Lee, Meletios A. Dimopoulos, Evangelos Terpos, Efstathios Kastritis, Wee Joo Chng, Artur J. Jurczyszyn, Hiroshi Handa, Shuji Ozaki, Xavier Leleu, Philippe Moreau, Juan José Lahuerta, Chaim Shustik, Daniel Dirck Waller, Meral Beksac, Ravi Vij, Kihyun Kim, Jin Seok Kim, Ashraf Z Badros, Melissa Alsina, Brian G. M. Durie
Journal: Blood (2015)
Human CD38 Is a Potential Therapeutic Target for Sekected Chronic Lymphocytic Leukemia cases.
Authors: Silvia Deaglio, Semra Aydin, Tiziana Vaisitti, Luciana Bergui, Giovanni D’Arena, Lisa Bonello, Ifigenia Saborit, Davide Rossi, Gianluca Gaidano, Giovanna Chiorino, Fabio Malavasi
Journal: Blood (2008)
Tcrαβ+/CD19+-Depletion in Hematopoietic Stem Cells Transplantation from Matched Unrelated and Haploidentical Donors Following Treosulfan or TBI-Based Conditioning in Pediatric Acute Lymphoblastic Leukemia Patients
Authors: Larisa Shelikhova, Zhanna Shekhovtsova, Dmitry Balashov, Elena Boyakova, Iakov Muzalevskyi, Elena Gutovskaya, Irina Shipitsina, Daria Shasheleva, Rimma Khismatullina, Sergey Blagov, Natalia Myakova, Andrey Abrosimov, Galina Novichkova, Alexey Maschan, Michael Maschan
Journal: Blood (2016)
Addressing Ethical Lapses in Research
Authors: Bernard Lo, Deborah Grady
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
LIF-LIF-R and SDF-1-CXCR4 Axes Regulate Overlapping and Complementary Steps of Metastasis of Rhabdomyosarcoma - Implication for Developing Better Antimetastatic Therapies.
Authors: Kasia Miekus, Marcin Wysoczynski, Ryan Reca, Gozdzik Jolanta, Bertolone J. Salvatore, Anna Janowska-Wieczorek, Mariusz Z. Ratajczak
Journal: Blood (2005)
Is Ashwell-Morell Receptor Mediated Hepatic Clearance of Platelet Clinically Relevant in Immune Thrombocytopenia (ITP)? a Retrospective Analysis of Platelet Kinetic Studies and Autoantibody Type Data
Authors: Silvia Cantoni, Monica Carpenedo, Domenico Sica Lanfranco, Michele Nichelatti, Massimo Milella, Angela Centroni, Roberto Cairoli
Journal: Blood (2015)
Results of Targeted Biopsy in Men with Magnetic Resonance Imaging Lesions Classified Equivocal, Likely or Highly Likely to Be Clinically Significant Prostate Cancer
Authors: Wulphert Venderink, Annemarijke van Luijtelaar, Joyce G.R. Bomers, Marloes van der Leest, Christina Hulsbergen-van de Kaa, Jelle O. Barentsz, J.P. Michiel Sedelaar, Jurgen J. Fütterer
Journal: European Urology (2017)
Comorbidities Index Is Not Predictive of Treatment Related Mortality in Patients (pts) Older Than 60 Years Treated with Reduced Intensity Conditioning and Allogeneic Stem Cell Transplantation (RIC-ALLO).
Authors: Luca Castagna, Sabine Furst, Jean El Cheikh, Catherine Faucher, Mohamad Mohty, Benjamin Esterni, Didier Blaise
Journal: Blood (2009)
Abstract ES4-1: Basic science of immunotherapy
Authors: KL Knutson
Journal: Cancer Research (2017)

Abstract While it remains unclear whether the immune system naturally evolved to prevent cancer, it is clear that many of its constituent cells and factors can greatly influence the clinical course of the disease in many different cancers, including breast cancer. Generally speaking, the immune system is a double edged sword and produces a broad array of both pro-tumor and anti-tumor factors. Of those which demonstrate anti-tumor activity, antigen-specific T cells (including both cytotoxic and helper T cells) are the most important as several studies have now shown that increased T cell infiltration is generally, and markedly, protective. More recent evidence also suggests that B cells can also be protective, particularly when producing tumor-specific antibodies or associated with intratumoral tertiary lymphoid structures. Thus, newer therapeutics being developed in academia and industry are being designed to directly augment adaptive immunity. The methods to manipulate the numbers of lymphocytes is growing and includes direct clonal expansion approaches such as vaccination and adoptive T cell therapy as well as more indirect methods that modulate cell intrinsic regulatory mechanisms (e.g. checkpoint and co-stimulatory pathways). In contrast, the pro-tumor activity of the immune system is largely mediated by the myeloid compartment of the immune system. While normal myeloid cells are not generally pro-tumorigenic, most tumors impair proper myeloid differentiation inducing intratumoral and systemic accumulation of defective myeloid cells which have profound tumor-promoting activity. This tumor-promoting activity of myeloid cells is mediated either through direct tumor growth-promoting activity (e.g. growth and angiogenic factors) or through blockade of adaptive immune response. Mechanisms by myeloid cells promote tumor growth appear to be diversified and are now only recently becoming understood, but nonetheless represent unique targets for therapeutic manipulation either alone in combination with other therapeutic modalities (e.g. checkpoint blockade). The basic underpinnings of tumor immunology are being rapidly identified and applied clinically to treat a variety of cancers and more recently breast cancer. This educational lecture will be a general overview of tumor immunology focusing on recent basic and therapeutic advances, highlighting those relevant to the field of breast cancer. Citation Format: Knutson KL. Basic science of immunotherapy [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr ES4-1.
Nitric Oxide Consumption and Pulmonary Hypertension in Patients with Paroxysmal Nocturnal Hemoglobinuria.
Authors: Anita Hill, Xunde Wang, Robert J. Sapsford, Rother P. Russell, Alison L. Farrell, Hilary A. Jessop, Gina M. McGawley, David L. Oxborough, Paul Pleasants, Stephen J. Richards, Louise M. Arnold, David M. Buchanan, Sara Rollinson, Mark T. Gladwin, Peter Hillmen
Journal: Blood (2005)
A Study of Twelve Southern California Communities with Differing Levels and Types of Air Pollution
Authors: JOHN M. PETERS, EDWARD AVOL, WILLIAM NAVIDI, STEPHANIE J. LONDON, W. JAMES GAUDERMAN, FRED LURMANN, WILLIAM S. LINN, HELENE MARGOLIS, EDWARD RAPPAPORT, HENRY GONG, DUNCAN C. THOMAS
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

To study possible chronic respiratory effects of air pollutants, we initiated a 10-yr prospective cohort study of Southern California children, with a study design focused on four pollutants: ozone, particulate matter, acids, and nitrogen dioxide (NO2). Twelve demographically similar communities were selected on the basis of historic monitoring information to represent extremes of exposure to one or more pollutants. In each community, about 150 public school students in grade 4, 75 in grade 7, and 75 in grade 10 were enrolled through their classrooms. Informed consent and written responses to surveys about students' lifetime residential histories, historic and current health status, residential characteristics, and physical activity were obtained with the help of the parents. In the first testing season, 3,676 students returned questionnaires. We confirmed associations previously reported between respiratory morbidity prevalence and the presence of personal, demographic, and residential risk factors. Rates of respiratory illness were higher for males, those living in houses with pets, pests, mildew, and water damage, those whose parents had asthma, and those living in houses with smokers. Wheeze prevalence was positively associated with levels of both acid (odds ratio [OR] = 1.45; 95% confidence interval [CI], 1.14–1.83) and NO2 (OR = 1.54; 95% CI, 1.08–2.19) in boys. We conclude, based on this cross-sectional assessment of questionnaire responses, that current levels of ambient air pollution in Southern California may be associated with effects on schoolchildren's respiratory morbidity as assessed by questionnaire.
Comorbidities, age, and outcomes among intensively treated patients with acute myeloid leukemia (AML).
Authors: Bernard Tawfik, Timothy S. Pardee, Scott Isom, Sarunas Sliesoraitis, Allison Winter, Julia Lawrence, Bayard L. Powell, Heidi D. Klepin
Journal: Journal of Clinical Oncology (2014)

e18024 Background: Little is known about how specific comorbidities affect outcomes among adults receiving intensive therapy for AML. Our goal was to characterize comorbidities by age and investigate their association with outcomes. Methods: We retrospectively analyzed consecutive patients with newly diagnosed AML treated with intensive therapy at Wake Forest Baptist Health from 2002-2009. Comorbidities diagnosed prior to start of chemotherapy were identified by ICD-9 codes and confirmed by chart review. Comorbidity burden was analyzed using the modified Charlson Comorbidity Index (CCI). Prevalent comorbid conditions were also analyzed individually. Outcomes were overall survival (OS) and 30-day mortality from time of chemotherapy initiation. Additional covariates included cytogenetics, age, hemoglobin, bilirubin, creatinine, insurance type and body mass index. Cox proportional hazards models were used to evaluate OS while logistic regression was used to evaluate 30-day mortality. Results: Among 280 AML patients, 146 were ≥60 years old (median age 70.3 yrs, 46% female, median survival 9.0 months) while 134 were <60 years (median age 44.3 yrs, 51% female, median survival 23.3 months). The most common regimens included anthracycline+cytarabine+etoposide (43% older versus 81% younger patients) and anthracycline+cytarabine (37% older versus 9% younger patients). Older patients had higher comorbidity burden (CCI≥1 in 59% versus 27%, p<0.001). Prevalent comorbid conditions differed by age (diabetes 19% versus 8%; cardiovascular disease 13% versus 5% for older versus younger respectively). The CCI was not associated with OS or 30-day mortality in either age group in multivariate analyses. Among older patients diabetes was associated with higher 30-day mortality (28.6% vs. 10.1% diabetic vs. non diabetic patients respectively, p = 0.03). After controlling for age and cytogenetic risk group presence of diabetes increased the odds of 30-day mortality by 4.9, (CI 1.6-15.1) Conclusions: Diabetes is adversely associated with 30-day survival in older AML patients receiving intensive therapy. If validated, this line of research may inform clinical decision-making and interventions to improve outcomes.
Patient and family engaged care—going beyond tactical buzzwords
Authors: Summer V Allen, Kerri Sparling, Victor M Montori
Journal: BMJ (2017)

Aim for better care, not simply more engagement

A scientific advisory panel convened by the National Academy of Medicine in the US has released a new framework for building and sustaining patient and family engaged care (PFEC).1 It described PFEC as “care planned, delivered, managed, and continuously improved in active partnership with patients and their families (or care partners as defined by the patient) to ensure integration of their health and healthcare goals, preferences, and values. It includes explicit and partnered determination of goals and care options, and it requires ongoing assessment of the care match with patient goals.”

PFEC should influence clinical decisions and policy making about the organisation and delivery of care, from the clinical encounter to the boardroom. The authors expect the framework to lower costs and to guide and catalyse collaborative actions to improve healthcare culture, care, and health outcomes. But this useful, hopeful, and potentially seminal report raises some concerns that give us, activists for engaged patient centred care, some pause.

The framework …
Acute Bilineal Leukemia Is a Very Rare Entity in Childhood
Authors: Ester Mejstrikova, Lucie Slamova, Eva Fronkova, Jana Volejnikova, Katerina Muzikova, Jiri Domansky, Jaroslav Sterba, Ondrej Zapletal, Zuzana Zemanova, Libuse Lizcova, Elena Vodickova, Jan Zuna, Jan Trka, Jan Stary, Ondrej Hrusak
Journal: Blood (2011)
Incidentally Detected Penile Metastases in a Patient of Carcinoma Urinary Bladder on Follow-up FDG PET/CT
Authors: Girish Kumar Parida, Sarthak Tripathy, Shambo Guha Roy, Abhinav Singhal, Chandanjyoti Das, Shamim Ahmed Shamim
Journal: Clinical Nuclear Medicine (2017)

Penis is an extremely uncommon site for metastases to occur and is often associated with very grave prognosis. Most of the secondary tumors originating in the penis have primaries from prostate, urinary bladder, and gastrointestinal tract. We hereby report a 65-year-old man, known case of carcinoma urinary bladder, who came for FDG PET/CT for metastatic workup. PET/CT study revealed FDG-avid mass lesion in the root and shaft of the penis, making it suggestive of metastases, which was confirmed later by MRI correlation.
Chronic Obstructive Pulmonary Disease Readmissions and Other Measures of Hospital Quality
Authors: Seppo T. Rinne, Jose Castaneda, Peter K. Lindenauer, Paul D. Cleary, Harold L. Paz, Jose L. Gomez
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Rationale: The Centers for Medicare and Medicaid Services recently implemented financial penalties to reduce hospital readmissions for select conditions, including chronic obstructive pulmonary disease (COPD). Despite growing pressure to reduce COPD readmissions, it is unclear how COPD readmission rates are related to other measures of quality, which could inform efforts on common organizational factors that affect high-quality care.Objectives: To examine the association between COPD readmissions and other quality measures.Methods: We analyzed data from the 2015 Centers for Medicare and Medicaid Services annual files, downloaded from the Hospital Compare website. We included 3,705 hospitals nationwide that had publically reported data on COPD readmissions. We compared COPD readmission rates to other risk-adjusted measures of quality, including readmission and mortality rates for other conditions, and patient reports about care experiences.Measurements and Main Results: There were modest correlations between COPD readmission rates and readmission rates for other medical conditions, including heart failure (r = 0.39; P < 0.01), acute myocardial infarction (r = 0.30; P < 0.01), pneumonia (r = 0.38; P < 0.01), and stroke (r = 0.29; P < 0.01). In contrast, we found low correlations between COPD readmission rates and readmission rates for surgical conditions, as well as mortality rates for all measured conditions. There were significant correlations between COPD readmission rates and all patient experience measures.Conclusions: These findings suggest there may be common organizational factors that influence multiple disease-specific outcomes. As pay-for-performance programs focus attention on individual disease outcomes, hospitals may benefit from in-depth assessments of organizational factors that affect multiple aspects of hospital quality.
Dyspnoea and an unusual chest radiograph
Authors: James SB Kho, David C Howlett
Journal: BMJ (2017)

A 70 year old man presents with shortness of breath over several months. What does his chest radiograph show (fig 1⇓), and what are the most common causes of this condition?



Fig 1  Chest radiograph



The chest radiograph shows pericardial calcification. Given his symptoms, consider echocardiography, as pericardial calcification is associated with constrictive pericarditis. Although it is often idiopathic, recognised causes of constrictive pericarditis include …
Should we commit to eradicating malaria worldwide?
Authors: Bruno Moonen, Clive Shiff
Journal: BMJ (2017)

Bruno Moonen cannot accept the iniquitous alternative, but Clive Shiff believes the necessary huge investment could be better spent

The World Health Organization,1 the Roll Back Malaria Partnership,2 and the United Nations3 all have a vision of a malaria-free world. The world has already committed to malaria eradication, albeit without a target date. More importantly, malaria endemic regions are setting ambitious elimination targets, showing a clear demand for, and commitment to, regional elimination and, eventually, global eradication.456

### Equitable and sustainable

For malaria, eradication is the only equitable and sustainable solution. Half of the world has already eliminated malaria,7 and, as Melinda Gates put it in 2007: “Any goal short of eradicating malaria is accepting malaria; it’s making peace with malaria; it’s rich countries saying: ‘We don’t need to eradicate malaria around the world as long as we’ve eliminated malaria in our own countries.’ That's just unacceptable.”8

The alternative, indefinite control, is not sustainable. Maintaining financial commitment, especially when the burden becomes low, is challenging, and history has shown that when programmes are not adequately funded malaria will resurge.9 Indefinite control would require constant investment in research and development to stay ahead of an ever evolving parasite and vector. Countries that eliminate, on the other hand, are more likely to remain malaria-free.10

The challenges in the polio endgame, operationally and financially, are obvious reasons for pause. As Chris Whitty, chief scientific adviser to the UK Department of Health, noted: “Trying and failing [to achieve] eradication is costly, pulls resources from other priorities, breeds cynicism, and may destroy good control programmes. The key, therefore, is not to call for it where we cannot achieve it, and, for most diseases, we cannot.”11

However, failures in control because of inconsistent funding are equally expensive,9 and …
Somatic TP53 mutations characterize preleukemic stem cells in acute myeloid leukemia
Authors: Ridhima Lal, Karin Lind, Ellen Heitzer, Peter Ulz, Kristina Aubell, Karl Kashofer, Jan M. Middeke, Christian Thiede, Eduard Schulz, Angelika Rosenberger, Sybille Hofer, Birgit Feilhauer, Beate Rinner, Vendula Svendova, Michael G. Schimek, Frank G. Rücker, Gerald Hoefler, Konstanze Döhner, Armin Zebisch, Albert Wölfler, Heinz Sill
Journal: Blood (2017)
Prognostic Impact of Delayed Platelet Engraftment after Allogeneic Hematopoietic Stem Cell Transplantation for Hematological Malignancy
Authors: Heiwa Kanamori, Jun Aoki, Eriko Ogusa, Akiko Negoro, Satoshi Koyama, Takayoshi Tachibana, Masatsugu Tanaka, Hideaki Nakajima
Journal: Blood (2016)
Mitotic Spindle Assembly Inhibition Through Aurora A (MLN8237) Plus Vincristine Is Synthetic Lethal and Synergizes with Rituximab As a Curative Therapy in Aggressive B-Cell Non-Hodgkin Lymphoma
Authors: Daruka Mahadevan, Laurence Cooke, Amy Stejskal, Ann Manziello, Carla Morales, Daniel O. Persky, Richard I Fisher, Thomas P. Miller, Wenqing Qi
Journal: Blood (2011)
Abstract P5-02-02: Combined use of elastography and color doppler ultrasound for the evaluation of breast masses detected at screening ultrasound in women with dense breasts
Authors: SH Lee, JM Chang, N Cho, A Yi, SH Choi, SH Kook, JH Youk, EJ Son, J Chung, ES Cha, HR Koo, JS Park, AJ Chu, KH Ko, HY Choi, EB Ryu, W Han, WK Moon
Journal: Cancer Research (2017)

Abstract This abstract was withdrawn by the authors.
CDC Grand Rounds: Public Health Strategies to Prevent Neonatal Abstinence Syndrome
Authors: Jean Y. Ko, Sara Wolicki, Wanda D. Barfield, Stephen W. Patrick, Cheryl S. Broussard, Kimberly A. Yonkers, Rebecca Naimon, John Iskander
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Neonatal abstinence syndrome (NAS) is a drug withdrawal syndrome that most commonly occurs in infants after in utero exposure to opioids, although other substances have also been associated with the syndrome (1). NAS usually appears within 48-72 hours of birth with a constellation of clinical signs, including central nervous system irritability (e.g., tremors), gastrointestinal dysfunction (e.g., feeding difficulties), and temperature instability (1) (Box 1). Opioid exposure during pregnancy might result from clinician-approved use of prescription opioids for pain relief; misuse or abuse of prescription opioids; illicit use (e.g., heroin); or medication-assisted treatment (MAT) of opioid use disorder (2) (Box 2).