tbuckley/cabot-search huggingface dataset:
Assessing caregiver satisfaction with care on an acute palliative care unit.
Authors: Ernie Mak, Patricia Murphy-Kane, Camilla Zimmermann
Journal: Journal of Clinical Oncology (2017)

51 Background: Accreditation Canada has adopted four main values for hospice, palliative, and end-of-life services: dignity and respect; information sharing; partnership and participation; and collaboration . These domains, as well as communication and joint decision-making, are important for satisfaction of caregivers for patients with cancer, and can be measured using the FAMCARE questionnaire. We aimed to assess satisfaction of caregivers for patient admitted to an acute palliative care unit at a comprehensive cancer center in Toronto, Canada. Methods: The FAMCARE questionnaire was administered by a trained volunteer to self-identified caregivers of patients who were admitted for more than five days on the acute palliative care unit. A short, anonymous demographic survey accompanied the FAMCARE questionnaire to gather information on relationship to patient, ethnicity, patient length of stay, and location of residence. The survey package either was completed in the presence of the volunteer, or was left to be completed by the caregiver alone and collected later by the volunteer. Results were reviewed regularly at the quality committee of the palliative care service. Results: From September 2014 to March 2017, 90 caregivers completed the questionnaire. Most caregivers were female (69%), identified as Canadian or Caucasian (57%), and lived in Toronto (63%). In all, 57% were spouses while 31% were children of the patient. Most patients had been admitted between a week and a month (67%). Care was rated as “Satisfied” or “Very satisfied” most of the time on all items (range 81-100%). The availability of nurses and doctors (100% satisfied/very satisfied) and the way tests and treatments were followed-up (99%) were rated highest. Information given about side effects (81%) and referral to specialists (83%) were rated lowest. Conclusions: Despite the nature of the acute palliative care unit, where patients admitted tend to be very ill with complex symptoms and psychosocial issues, caregiver satisfaction was high. Future research will examine whether caregivers of different ethnicities value different aspects of cancer care.
Long-Term Visual Outcomes and Safety Profile of 27-Gauge Pars Plana Vitrectomy for Posterior Segment Disease
Authors: M. Ali Khan, Alexander Kuley, Christopher D. Riemann, Maria H. Berrocal, Rohit R. Lakhanpal, Jason Hsu, Arunan Sivalingam, Allen C. Ho, Carl D. Regillo
Journal: Ophthalmology (2017)
Enhancing the precision of genetic lineage tracing using dual recombinases
Authors: Lingjuan He, Yan Li, Yi Li, Wenjuan Pu, Xiuzhen Huang, Xueying Tian, Yue Wang, Hui Zhang, Qiaozhen Liu, Libo Zhang, Huan Zhao, Juan Tang, Hongbin Ji, Dongqing Cai, Zhibo Han, Zhongchao Han, Yu Nie, Shengshou Hu, Qing-Dong Wang, Ruilin Sun, Jian Fei, Fengchao Wang, Ting Chen, Yan Yan, Hefeng Huang, William T Pu, Bin Zhou
Journal: Nature Medicine (2017)
Evolving Delivery System and Market Factors and Their Influence on Physician Networks and Patient Care
Authors: James D. Reschovsky, Eugene C. Rich
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
2:32 a.m.
Authors: Sergio Waxman
Journal: Annals of Internal Medicine (2017)

On Being a Doctor21 November 20172:32 a.m.Sergio Waxman, MD, MBASergio Waxman, MD, MBALahey Hospital & Medical Center, Burlington, Massachusetts (S.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M17-0175 Audio Reading - “2:32 a.m.” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "2:32 a.m.," by S. Waxman. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It is 2:32 in the morning. The sound of my pager pierces through the quiet in the house. I half jump off the bed, my heart pounding and my mind somewhat disoriented. I pick up the telephone at my side and start dialing. A muffled, rambling voice answers on the other side. “On my way,” I mumble and give up a sigh as I hang up. I manage to get dressed through the darkness as I tiptoe my way around. “Be careful!” I hear my wife whisper as I leave the bedroom and see her turning in bed back to ... Author, Article, and Disclosure InformationAffiliations: Lahey Hospital & Medical Center, Burlington, Massachusetts (S.W.)Corresponding Author: Sergio Waxman, MD, MBA, Lahey Hospital & Medical Center, 41 Mall Road, Burlington, MA 01805; e-mail, sergio.[email protected]org. PreviousarticleNextarticle Advertisement Audio Reading - “2:32 a.m.” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "2:32 a.m.," by S. Waxman. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byVoices from the Front Lines: An Analysis of Physicians’ Reflective Narratives about Flaws with the ‘System’Voices from the Front Lines: An Analysis of Physicians’ Reflective Narratives about Flaws with the ‘System’ 21 November 2017Volume 167, Issue 10Page: 752KeywordsBrainCoffeeEpinephrineFatigueGamesHeartSleepSmellThoraxWalking ePublished: 21 November 2017 Issue Published: 21 November 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
British Thoracic Society Clinical Statement on Pulmonary Arteriovenous Malformations
Authors: Claire L Shovlin, Robin Condliffe, James W Donaldson, David G Kiely, Stephen J Wort
Journal: Thorax (2017)

Pulmonary arteriovenous malformations (PAVMs) are structurally abnormal vascular communications that provide a continuous right-to-left shunt between pulmonary arteries and veins. Their importance stems from the risks they pose (>1 in 4 patients will have a paradoxical embolic stroke, abscess or myocardial infarction while life-threatening haemorrhage affects 1 in 100 women in pregnancy), opportunities for risk prevention, surprisingly high prevalence and under-appreciation, thus representing a challenging condition for practising healthcare professionals. The driver for the current Clinical Statement was the plethora of new data since previous hereditary haemorrhagic telangiectasia (HHT) guidelines generated in 2006 and a systematic Cochrane Review for PAVM embolisation in 2011. The British Thoracic Society (BTS) identified key areas in which there is now evidence to drive a change in practice. Due to the paucity of data in children, this Statement focused on adults over 16 years. The Statement spans the management of PAVMs already known to be present (interventional and medical), screening and diagnosis (for PAVMs and HHT) and follow-up of patients following a first diagnosis, intervention or negative screen for PAVMs. The Good Practice Points (in bold) were generated for a target audience of general respiratory, medical and specialist clinicians and were approved by the BTS Standards of Care Committee, before formal peer review and public consultation. The Statement spans embolisation treatment, accessory medical management and issues related to the likelihood of underlying HHT.
Assessment of the impact of the Hospital Anxiety and Depression Scale on the initiation of treatment in newly diagnosed cancer patients in a safety-net hospital.
Authors: Daulath Singh, Annapoorna Singh, Punita Grover, Mahathi Indaram, Nikki Malomo, An-Lin Cheng, Richard Arden Johnson, Sheshadri Madhusudhana
Journal: Journal of Clinical Oncology (2017)

250 Background: Distress is a universal symptom in oncologic patients which negatively impact the quality of life and survival. It interferes with the ability to cope with the diagnosis and is a risk factor for non-adherence with treatment. The Hospital Anxiety and Depression Scale (HADS), is used at our institution for distress screening. The aim of our study is to assess the impact of distress, measured by the HADS score, on initiation of treatment in newly diagnosed cancer patients. Methods: We conducted a retrospective chart review of patients with a new diagnosis of cancer, between March 1 st , 2014 and December 31 st , 2015; who had been evaluated for distress at their first oncology clinic visit. We included only patients who were treated with chemotherapy or chemoradiation, with curative intent. Poisson regression analysis was conducted to investigate the relationship between HADS to treatment initiation while including age, sex, race, insurance status, cancer type, and stage as covariates in the model. Results: A total of 101 patients met the inclusion criteria. The mean age was 54 years, 63% were female and 37% were male. The majority were Caucasians (53%), followed by African-Americans (36%). 56% of the population had Medicaid, and 26% had Medicare and private insurance. The most common cancers were – breast (30%), gastrointestinal (20%), gynecologic (15%) and lung (11%). 64% received chemotherapy and 36% were treated with chemoradiation. We grouped patients into 3 categories based on the HADS score – category 1 with score ≤7 (28%), category 2 with score 8-10 (17%) and category 3 with score ≥11 (55%). The median time to treatment initiation was 28 days. Multivariate Poisson regression analysis did not show any correlation between the HADS score and treatment initiation. Subscales analyses showed that higher depression scores correlate with a delay in treatment initiation (p-value 0.01), while the anxiety scores had no influence (p-value 0.57). Conclusions: In our study, the initial total HADS score did not affect the treatment initiation. Interestingly, depression had an influence on the initiation of treatment in newly diagnosed cancer patients.
Clinical Features, Management, and Outcomes of Immune Checkpoint Inhibitor–Related Cardiotoxicity
Authors: Marion Escudier, Jennifer Cautela, Nausicaa Malissen, Yann Ancedy, Morgane Orabona, Johan Pinto, Sandrine Monestier, Jean-Jacques Grob, Ugo Scemama, Alexis Jacquier, Nathalie Lalevee, Jeremie Barraud, Michael Peyrol, Marc Laine, Laurent Bonello, Franck Paganelli, Ariel Cohen, Fabrice Barlesi, Stephane Ederhy, Franck Thuny
Journal: Circulation (2017)

niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Statins and risk of decompensation in hepatitis B virus–related and hepatitis C virus–related cirrhosis: Methodological issues
Authors: Chun‐Yu Lin
Journal: Hepatology (2017)

Potential conflict of interest: Nothing to report. TO THE EDITOR: We read the article by Chang et al.,1 in which the authors used a nationwide database and reported that statin use is associated with lower decompensation rates in both hepatitis B virus–related and hepatitis C virus–related cirrhosis. Their findings support the use of statins in the prevention of decompensation in patients with cirrhosis. However, several methodological issues need to be clarified before extrapolating their results to patients with hepatitis B virus–related or hepatitis C virus–related cirrhosis. First, the authors adopted the method of new user design in their work and arbitrarily defined the date of first statin prescription as the index date for the statin users. In contrast, statin nonusers were followed up from the date of cirrhosis diagnosis. Although this approach can avoid misclassified immortal time, excluded immortal time may introduce selection bias (another form of immortal time bias).2 It has been shown that results can be biased toward a protective effect of treatment by either misclassified immortal time or excluded immortal time.3 They also did not report the mean interval between the date of diagnosis of cirrhosis and the date of first statin prescription, which would influence the magnitude of bias. Second, hepatotoxicity is a concern in the prescription of statins in patients with chronic liver disease. In real‐world practice, many physicians are reluctant to initiate statins in patients with an out‐of‐range liver enzyme value.4 Statin users in this study may just represent groups with better liver function reserve and slower progression of fibrosis compared to statin nonusers. Although propensity score matching was used to minimized confounding by indication of statin and the authors included 14 covariates in their logistic regression model to calculate propensity scores, some of the confounding mentioned above may still exist between statin users and nonusers due to a lack of important laboratory data such as liver enzyme and bilirubin levels in their database. We agree that statin use may be beneficial in patients with liver cirrhosis; however, the results of this study may amplify the advantage of these drugs due to selection bias and incomplete control over the confounding factors between statin users and nonusers.
A Pilot Digital Tele-Exercise Program In Children With Cystic Fibrosis
Authors: J Chen, S Radom-Aizik, A Sladkey, J Nam, TT Vu, E Nussbaum, DM Cooper
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

C61 SUPPURATIVHUHGDISlASES IN CKILDRfH / Thcm.ttkPOStei Seulon!Tw~ay. M.ty llJ9:1S ~:I SPM / /UN II. li.1118  70% maximum HR for > 1 S minutes per session. Results from the system usability survey suggestedl that the exercise platform was easy to use by most participants without parental guidance. A jOr'edomlnant theme that emerged from the qualit.a live survey was me general enjoyment of the group experience. For example, participants cited seeing their frie«'lds and instructor and chatting with people during the workout as advantages of the Sludy. All pan fcipants but one desired to cootinue the exercise p109ram. Conclusions: Digital tele~xercise deUvery is a promi$ing approach t o promoting exercise in children with CF. By using an Online ~atform, we were able to overcome the cross-Infection risk and transportation challenges, and encoorage participation through the convenience of streamed exercise sessions directly to the participant. Although they were located in diffE!f'ent cities. participants enjoyed exercising in a group setting that mimicked in-person training and allowed the children and insuuetOf' to interact with one another. further investigation is warranted to evaluate the physiologic effects of digital tele-exercise on fitness and disease management In CF. This absttact is funded by: Mem0tialCare Foondatlon AmJ A•splr CrltCar• Med 2 0 17;19S:A6141 lntttMt addnss.: www.aujo\lmab.ort Online Abstracts luuoe
Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics
Authors: E. Stoffel, H. Maier, E. Riedl, M.-C. Brüggen, B. Reininger, M. Schaschinger, C. Bangert, E. Guenova, G. Stingl, P.M. Brunner
Journal: British Journal of Dermatology (2017)

Psoriasiform and eczematous eruptions are the most common dermatological adverse reactions linked to anti-tumour necrosis factor (TNF)-α therapy. Yet, a detailed characterization of their immune phenotype is lacking.To characterize anti-TNF-α-induced inflammatory skin lesions at a histopathological, cellular and molecular level, compared with psoriasis, eczema (atopic dermatitis) and healthy control skin.Histopathological evaluation, gene expression (quantitative real-time polymerase chain reaction) and computer-assisted immunohistological studies (TissueFAXS) were performed on 19 skin biopsies from patients with inflammatory bowel disease (n = 17) and rheumatoid arthritis (n = 2) with new-onset inflammatory skin lesions during anti-TNF-α-therapy.Although most biopsies showed a psoriasiform and/or spongiotic (eczematous) histopathological architecture, these lesions were inconsistent with either psoriasis or eczema on a molecular level using an established chemokine (C-C motif) ligand 27/inducible nitric oxide synthase classifier. Despite some differences in immune skewing depending on the specific histopathological reaction pattern, all anti-TNF-α-induced lesions showed strong interferon (IFN)-γ activation, at higher levels than in psoriasis or eczema. IFN-γ was most likely produced by CD3/CD4/Tbet-positive T helper 1 lymphocytes.New-onset anti-TNF-α-induced eruptions previously classified as psoriasis or spongiotic dermatitis (eczema) exhibit a molecular profile that is different from either of these disorders.
Terbinafine induced liver injury may be asymptomatic: need for regular monitoring
Authors: A. Khurana, K. Sardana, V. Bhardwaj
Journal: British Journal of Dermatology (2017)

We read with interest the article by Kramer et al entitled “Clinical presentation of terbinafine-induced severe liver injury and the value of laboratory monitoring: a critically appraised topic”. 1 We would like to bring to focus our experience in this regard. With increasing concerns of reduced susceptibility to terbinafine2 and an upsurge of recalcitrant cutaneous dermatophytoses, dermatologists in India have been using higher doses of terbinafine for cutaneous dermatophytoses, as used in the early literature with this drug (upto 500mg/day in single or divided doses) 3; and for longer periods of time.

This article is protected by copyright. All rights reserved.
Engineering Approaches to Assessing Hydration Status
Authors: David C. Garrett, Nyssa Rae, Jared R. Fletcher, Sasha Zarnke, Sarah Thorson, David B. Hogan, Elise C. Fear
Journal: IEEE Reviews in Biomedical Engineering (2017)

Dehydration is a common condition characterized by a decrease in total body water. Acute dehydration can cause physical and cognitive impairment, heat stroke and exhaustion, and, if severe and uncorrected, even death. The health effects of chronic mild dehydration are less well studied with urolithiasis (kidney stones) the only condition consistently associated with it. Aside from infants and those with particular medical conditions, athletes, military personnel, manual workers, and older adults are at particular risk of dehydration due to their physical activity, environmental exposure, and/or challenges in maintaining fluid homeostasis. This review describes the different approaches that have been explored for hydration assessment in adults. These include clinical indicators perceived by the patient or detected by a practitioner and routine laboratory analyses of blood and urine. These techniques have variable accuracy and practicality outside of controlled environments, creating a need for simple, portable, and rapid hydration monitoring devices. We review the wide array of devices proposed for hydration assessment based on optical, electromagnetic, chemical, and acoustical properties of tissue and bodily fluids. However, none of these approaches has yet emerged as a reliable indicator in diverse populations across various settings, motivating efforts to develop new methods of hydration assessment.
Developmental psycholinguistics teaches us that we need multi-method, not single-method, approaches to the study of linguistic representation
Authors: Caroline F. Rowland, Padraic Monaghan
Journal: Behavioral and Brain Sciences (2017)

Abstract In developmental psycholinguistics, we have, for many years, been generating and testing theories that propose both descriptions of adult representations and explanations of how those representations develop. We have learnt that restricting ourselves to any one methodology yields only incomplete data about the nature of linguistic representations. We argue that we need a multi-method approach to the study of representation.
P3.02a-028 Anaplastic Lymphoma Kinase Fusion Oncogene Positive Non-Small Cell Lung Cancer - The Experience of an Institution
Authors: Sérgio Azevedo, Li Bei, Joana Cunha, Cristina Oliveira, Ana Rodrigues, Inés Pousa, Isabel Azevedo, Júlio Oliveira, Marta Soares
Journal: Journal of Thoracic Oncology (2017)
It is time to replace publish or perish with get visible or vanish: opportunities where digital and social media can reshape knowledge translation
Authors: Christian J Barton, Mark A Merolli
Journal: British Journal of Sports Medicine (2017)

Knowledge translation (KT) is defined as ‘the synthesis, exchange and application of knowledge by relevant stakeholders to accelerate the benefits of global and local innovation in strengthening health systems and improving people’s health’.1 We acknowledge the growing number of theories, models and frameworks to guide researchers and policy makers on all the complexities of KT.2 The aim of this analysis is to discuss how journal publishers, researchers and health professionals can use digital innovation (ie, application of new technologies to existing practices and problems) to reshape the KT path in healthcare. 

### Digital innovation

The application of new technologies to existing practices and problems (eg, using digital social media to facilitate knowledge translation).

We will outline (1) how digital innovation has already changed journal publishing, (2) the current digital and social media landscape with its limitations and (3) highlight opportunities to reshape the KT path in a rapidly evolving area. We intend to guide journal publishers, researchers and other stakeholders to help ensure they do not become irrelevant in the face of digital innovation.

The lead author of this review recently summarised the 300-year-old traditional academic journal publishing process into two broad steps—(1) research completion and (2) journal publication.3 These two steps do not adequately facilitate KT in any discipline. Therefore, he proposed two novel steps to improve efficiency and reach by embracing digital innovation: (3) multimedia creation and (4) social media dissemination (see figure 1).3 These digital innovations are not the sole answer to bridging the current evidence practice gap.4 5 However, based on our analysis, we believe digital innovation has been underused in KT, especially when compared with mainstream media. Of note, a number of media organisations have failed or drastically downsized in the past few years. Our ‘call to action’ to journal publishers and …