tbuckley/cabot-search huggingface dataset:
Abstract 18955: Detection of Chest Compressions Using Transthoracic Impedance
Authors: A. R Ramachandran, Jason Coult, Peter Kudenchuk, Jennifer Blackwood, Lawrence Sherman, Thomas Rea
Journal: Circulation (2015)

Objective: Real-time detection of chest compressions during resuscitation can provide essential feedback to rescuers about CPR quality. Accelerometer technology can accurately detect compressions, but requires added equipment and expense. Conversely, the transthoracic chest impedance signal is recorded by nearly all defibrillators, and offers a more available means to characterize chest compressions. This work aims to develop and test an algorithm to accurately detect chest compressions using frequency characteristics of the impedance signal. Methods: To train the chest compression detection algorithm, 6-second impedance clips were taken from a convenience sample of 82 out-of-hospital cardiac arrest patients. Data from a separate group of 173 patients were used as a validation set to determine performance, using concurrently collected accelerometer data as the reference for true chest compressions. Clips were collected randomly during either compressions or pauses. Clips with transitions between compressions and pauses were excluded. The detection algorithm used bandpass filtering to eliminate ventilations and artifact outside normal chest compression frequencies. Spectral peak analysis between 1-4 Hz was employed to eliminate harmonics of the fundamental chest compression frequency and detect true compressions. Results: Of 1258 6-second clips from the 173 patients in the validation dataset (846 with chest compressions and 412 without), the sensitivity and specificity of the impedance-based compression detection algorithm were 98.7% [97.7, 99.4] and 96.4% [94.1, 98.0], respectively. Conclusion: An impedance-based algorithm can detect chest compressions with high accuracy using frequency analysis, and provides a potentially valuable tool for assessing resuscitation quality.
Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function
Authors: Matthew C. Altman, Stephen R. Reeves, Andrew R. Parker, Elizabeth Whalen, Kira M. Misura, Kaitlyn A. Barrow, Richard G. James, Teal S. Hallstrand, Steven F. Ziegler, Jason S. Debley
Journal: Journal of Allergy and Clinical Immunology (2017)
TCT-670 Treating LAD Disease with a Long Stent may be Associated with Increased Cardiac Mortality Independent of Other Ischemic Events
Authors: Akiko Fujino, Akiko Maehara, Yangbo Liu, Pieter Smits, Clemens von Birgelen, Martin Leon, Patrick Serruys, Gary Mintz, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Tissue adhesive FK506–loaded polymeric nanoparticles for multi–layered nano–shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model
Authors: Tung Thanh Pham, Tiep Tien Nguyen, Shiva Pathak, Shobha Regmi, Hanh Thuy Nguyen, Tuan Hiep Tran, Chul Soon Yong, Jong Oh Kim, Pil–Hoon Park, Min Hui Park, Young Kyung Bae, Jeong Uk Choi, Youngro Byun, Cheol–Hee Ahn, Simmyung Yook, Jee–Heon Jeong
Journal: Biomaterials (2017)
TCT-803 Safety and efficacy of bioresorbable coronary devices in clinical practice: 1-year final results from the multicenter prospective REPARA registry
Authors: Felipe Hernandez, Eduardo Pinar Bermudez, Eduardo Molina, Jose Diaz, Hipolito Gutierrez, Neus Salvatella, Xavier Carrillo, Javier Zueco, Joan Antoni Gomez-Hospital, Andres Iñiguez, Cristóbal A. Urbano Carrillo, Pedro Canas da Silva, Armando Perez de Prado, Pablo Salinas, Juan Sanchis Fores, Jose Rumoroso, Pablo Pinon, Pablo Avanzas, Jose Ramon Lopez Minguez, Monica Masotti, Alfonso Torres, Raul Moreno, Iñigo Lozano, Joan Bassaganyas, Juan H. Alonso Briales, Juan Francisco Oteo Dominguez, Joao Costa, Leire Andraka, Antonio Serra, Bruno Garcia, Ricardo Santos, Vasco Gama Ribeiro, Dinis Martins, Jose de la Torre Hernandez
Journal: Journal of the American College of Cardiology (2017)
Smoking paradox in the development of psoriatic arthritis among patients with psoriasis: a population-based study
Authors: Uyen-Sa D T Nguyen, Yuqing Zhang, Na Lu, Qiong Louie-Gao, Jingbo Niu, Alexis Ogdie, Joel M Gelfand, Michael P LaValley, Maureen Dubreuil, Jeffrey A Sparks, Elizabeth W Karlson, Hyon K Choi
Journal: Annals of the Rheumatic Diseases (2017)

Smoking is associated with an increased risk of psoriatic arthritis (PsA) in the general population, but not among patients with psoriasis. We sought to clarify the possible methodological mechanisms behind this paradox.
Shotgun proteomic analysis of 1500 laser captured microdissected cells from breast tumor tissue using a short stack SDS-PAGE/in-gel digestion and LC-MS/MS
Authors: Eduardo Dias, Lisa Zimmerman, Amy-Joan Ham, Daniel Liebler, Carlos Arteaga, Melinda Sanders
Journal: Cancer Research (2007)

LB-378  Background: Proteomic evaluation of clinical samples has enormous potential to decipher the complex molecular events underlying neoplastic transformation. The development of assays for the analysis of tissue is often confounded by the presence of multiple cell types within the sample as well as the small size of most biopsy tissue. In addition, tumor may be present only focally within the biopsy. The use of laser capture microdissection (LCM) allows for the isolation of a nearly pure cell population from heterogeneous tissues, markedly enhancing the specificity of subsequent analyses. Unfortunately, the number of cells typically dissected by LCM usually limits proteome coverage to primarily abundant proteins, severely compromising biomarker discovery potential achievable by standard proteomic platforms. We present here an improved technique for facilitating sample clean-up and analysis of small numbers of cells isolated by LCM utilizing a short-stack SDS-PAGE and tandem mass spectrometry.  Methods: Cells from human breast tumors were LCM-acquired (Arcturus Pix Cell II) from a frozen tissue section. Proteins were isolated from LCM-acquired cells by boiling the thermoplastic membrane in SDS sample loading buffer and then run into a 10-20% Tricine precast gel approximately 1.5-2 cm, followed by in-gel trypsin digestion and peptide extraction. The peptides resulting from approximately 4000 cells were fractionated first by strong cation exchange (SCX) chromatography and each fraction was subsequently analyzed by reverse-phase liquid chromatography-tandem mass spectrometry (LC-MS-MS) on a Thermo LTQ ion trap instrument. Data were searched against the UniRef100 human database using the SEQUEST algorithm. False positive rates were estimated using reverse database searching.  >Results: Cells collected from breast tumor tissue using LCM were analyzed using LC-MS-MS. One dimensional analysis using only reversed-phase separation of the LCM digests identified 1650 peptides and a total of 230 proteins identified by 2 or more unique peptides. Fractionation using SCX prior to LC-MS-MS, identified 7813 peptides and 1071 proteins with at least two peptide hits from an equivalent of ~800 cells. False positive rates for these data at both the protein and peptide level were well below 3 and 1%, respectively. Based on function, the identified proteins cover a wide range of biological functions as well as distribution within cells.  >Discussion: These results demonstrate that a surprisingly large number of proteins can be identified in shotgun analyses of lysates prepared from as few as 1500 LCM-acquired cells and highlight the potential feasibility of this approach to in-depth proteomic analysis of human tumor samples.
Brote de sarampión en niños menores de 15 meses en La Rioja, España, 2005-2006
Authors: M Perucha, E Ramalle-Gómara, M E Lezaun, A Blanco, C Quiñones, M Blasco, M A Gonzalez, C Cuesta, J E Echevarria, M M Mosquera, F de Ory
Journal: Eurosurveillance (2006)

Describimos un brote de sarampion en La Rioja (Espana) que comenzo en diciembre de 2005 y que afecto fundamentalmente a lactantes menores de 15 meses y por tanto no vacunados con triple virica (MMR). Los casos fueron notificados a traves del sistema de Enfermedades de Declaracion Obligatoria y se confirmaron por laboratorio. Se clasificaron en sospechosos y confirmados, segun las definiciones del Plan Nacional de Eliminacion del Sarampion. En el periodo comprendido entre el 14 de diciembre de 2005 y el 19 de febrero de 2006 se investigaron 29 casos sospechosos de sarampion (18 confirmados). El periodo medio de incubacion fue de 13,8 dias (minimo 9, maximo 18). De los 18 casos confirmados, solo dos eran adultos. Se recomendo la vacunacion MMR en los contactos familiares y en los ninos entre 6 y 14 meses que acudian a las guarderias donde aparecieron casos. En estas guarderias se adelanto la segunda dosis de MMR en menores de tres anos. En todos los ninos de 9 a 14 meses de La Rioja se recomendo adelantar la primera dosis de vacuna. Durante un brote epidemico de sarampion, los ninos de seis o mas meses de edad, sin vacunacion previa frente a triple virica, deben recibir una primera dosis tan pronto como sea posible, y los que tengan una primera dosis, deben recibir una segunda lo mas rapido posible, siempre que haya pasado un minimo de un mes entre ambas dosis.
Valganciclovir for the Early Prophylaxis of Cytomegalovirus (CMV) Infection after Allogeneic Stem Cell Transplantation.
Authors: Carlos Bachier, Paul Shaughnessy, Donna Wall, Michael Grimley, George Carrum, Cesar Freytes, Natalie Callander, Tracey Walsh, C. Fred LeMaistre
Journal: Blood (2004)
Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI
Authors: Heather M. Perry, Liping Huang, Rebecca J. Wilson, Amandeep Bajwa, Hiromi Sesaki, Zhen Yan, Diane L. Rosin, David F. Kashatus, Mark D. Okusa
Journal: Journal of the American Society of Nephrology (2017)

The proximal tubule epithelium relies on mitochondrial function for energy, rendering the kidney highly susceptible to ischemic AKI. Dynamin-related protein 1 (DRP1), a mediator of mitochondrial fission, regulates mitochondrial function; however, the cell-specific and temporal role of DRP1 in AKI in vivo is unknown. Using genetic murine models, we found that proximal tubule–specific deletion of Drp1 prevented the renal ischemia-reperfusion–induced kidney injury, inflammation, and programmed cell death observed in wild-type mice and promoted epithelial recovery, which associated with activation of the renoprotective β -hydroxybutyrate signaling pathway. Loss of DRP1 preserved mitochondrial structure and reduced oxidative stress in injured kidneys. Lastly, proximal tubule deletion of DRP1 after ischemia-reperfusion injury attenuated progressive kidney injury and fibrosis. These results implicate DRP1 and mitochondrial dynamics as an important mediator of AKI and progression to fibrosis and suggest that DRP1 may serve as a therapeutic target for AKI.
scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing
Authors: Gal Avital, Roi Avraham, Amy Fan, Tamar Hashimshony, Deborah T. Hung, Itai Yanai
Journal: Genome biology (2017)

The interaction between a pathogen and a host is a highly dynamic process in which both agents activate complex programs. Here, we introduce a single-cell RNA-sequencing method, scDual-Seq, that simultaneously captures both host and pathogen transcriptomes. We use it to study the process of infection of individual mouse macrophages with the intracellular pathogen Salmonella typhimurium. Among the infected macrophages, we find three subpopulations and we show evidence for a linear progression through these subpopulations, supporting a model in which these three states correspond to consecutive stages of infection.
New Insights into Graft-Versus-Host Disease and Graft Rejection
Authors: Eric Perkey, Ivan Maillard
Journal: Annual Review of Pathology Mechanisms of Disease (2017)

Allogeneic transplantation of foreign organs or tissues has lifesaving potential, but can lead to serious complications. After solid organ transplantation, immune-mediated rejection mandates the use of prolonged global immunosuppression and limits the life span of transplanted allografts. After bone marrow transplantation, donor-derived immune cells can trigger life-threatening graft-versus-host disease. T cells are central mediators of alloimmune complications and the target of most existing therapeutic interventions. We review recent progress in identifying multiple cell types in addition to T cells and new molecular pathways that regulate pathogenic alloreactivity. Key discoveries include the cellular subsets that function as potential sources of alloantigens, the cross talk of innate lymphoid cells with damaged epithelia and with the recipient microbiome, the impact of the alarmin interleukin-33 on alloreactivity, and the role of Notch ligands expressed by fibroblastic stromal cells in alloimmunity. While refining our understanding of transplantation immunobiology, these findings identify new therapeutic targets and new areas of investigation.
TCT-162 Surgical Bioprosthesis Size Definition and Hemodynamic Performance following Aortic Valve-in-Valve: Insights from the Valve-in-Valve International Data (VIVID) Registry
Authors: Massimo Napodano, Vinayak Bapat, Antonio Landi, Matheus Simonato dos Santos, Mauricio Cohen, Yaron Arbel, James McCabe, Richard Smalling, Santiago Garcia, Michael J. Reardon, Ankur Kalra, Oscar Mendiz, Tony Walton, Noah Jones, Arun Thukkani, Gidon Perlman, Adnan Chhatriwalla, Danny Dvir
Journal: Journal of the American College of Cardiology (2017)
Aménagement hospitalier et prise en charge des patients atteints de fièvre hémorragique virale ou de variole à l’Institut Lazzaro Spallanzani, Rome, Italie
Authors: G Ippolito, E Nicastri, M R Capobianchi, A Di Caro, N Petrosillo, V Puro
Journal: Eurosurveillance (2005)

Les cas americains de charbon en 2001 et l’epidemie recente du syndrome respiratoire aigu severe ont souligne la necessite de preparation et de reponse aux infections emergentes ou re-emergentes naturellement et aux agents pathogenes dissemines volontairement. 
Le rapport suivant decrit le modele de reponse de l’Institut national pour les maladies infectieuses (INMI, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Rome, Italie) pour la prise en charge de patients atteints – ou suspectes - de variole ou de fievre hemorragique virale (FHV), que ce soit dans un contexte d’une emission deliberee du virus ou d’une infection survenue naturellement. 
En Italie, l’INMI est l’etablissement hospitalier de reference en termes de plan de preparation et de reponse aux agents infectieux lies au bioterrorisme. Toutes les chambres individuelles et doubles sont equipees de pression d’air negative, de portes blindees, de filtres HEPA (high efficiency particulate air), ainsi que d’un sas d’accueil entierement equipe. De plus, une unite de haute securite avec un laboratoire attenant pour les premiers tests de diagnostic destinee aux cas sporadiques necessitant un isolement de haute securite. Pour le transport les patients, l’institut dispose de deux ambulances totalement equipees et de deux civieres en milieu sterile avec une section a pression negative. Les tests diagnostiques moleculaires et traditionnels sont realises actuellement dans les laboratoires de niveau de securite P3/P4. 
Poursuivre l’education et la formation du personnel soignant, l’application stricte des pratiques de controle des infections et la mise a disposition d’un equipement adapte pour la protection du personnel : l’ensemble de ces ressources permettent une prise en charge de ces patients hautement contagieux, et le maintien d’une equipe reactive et correctement formee pour reagir face a des epidemies a grande echelle.
TCT-315 Safety and Feasibility of Low Dose Compared With Standard Dose Radiation for Cardiac Catheterization and Intervention
Authors: Mohamed Teleb, Aymen Albaghdadi, Ahmed Ibrahim, Debabrata Mukherjee, Harsh Agrawal, Juan Marmol-Velez, Tariq Siddiqui, Subrata Kar
Journal: Journal of the American College of Cardiology (2017)
Safety, pharmacokinetics, and antitumor response of depatuxizumab mafodotin as monotherapy or in combination with temozolomide in patients with glioblastoma
Authors: Hui K Gan, David A Reardon, Andrew B Lassman, Ryan Merrell, Martin van den Bent, Nicholas Butowski, Zarnie Lwin, Helen Wheeler, Lisa Fichtel, Andrew M Scott, Erica J Gomez, JuDee Fischer, Helen Mandich, Hao Xiong, Ho-Jin Lee, Wijith P Munasinghe, Lisa A Roberts-Rapp, Peter J Ansell, Kyle D Holen, Priya Kumthekar
Journal: Neuro-Oncology (2017)

We recently reported an acceptable safety and pharmacokinetic profile of depatuxizumab mafodotin (depatux-m), formerly called ABT-414, plus radiation and temozolomide in newly diagnosed glioblastoma (arm A). The purpose of this study was to evaluate the safety and pharmacokinetics of depatux-m, either in combination with temozolomide in newly diagnosed or recurrent glioblastoma (arm B) or as monotherapy in recurrent glioblastoma (arm C).In this multicenter phase I dose escalation study, patients received depatux-m (0.5-1.5 mg/kg in arm B, 1.25 mg/kg in arm C) every 2 weeks by intravenous infusion. Maximum tolerated dose (MTD), recommended phase II dose (RP2D), and preliminary efficacy were also determined.Thirty-eight patients were enrolled as of March 1, 2016. The most frequent toxicities were ocular, occurring in 35/38 (92%) patients. Keratitis was the most common grade 3 adverse event observed in 6/38 (16%) patients; thrombocytopenia was the most common grade 4 event seen in 5/38 (13%) patients. The MTD was set at 1.5 mg/kg in arm B and was not reached in arm C. RP2D was declared as 1.25 mg/kg for both arms. Depatux-m demonstrated a linear pharmacokinetic profile. In recurrent glioblastoma patients, the progression-free survival (PFS) rate at 6 months was 30.8% and the median overall survival was 10.7 months. Best Response Assessment in Neuro-Oncology responses were 1 complete and 2 partial responses.Depatux-m alone or in combination with temozolomide demonstrated an acceptable safety and pharmacokinetic profile in glioblastoma. Further studies are currently under way to evaluate its efficacy in newly diagnosed (NCT02573324) and recurrent glioblastoma (NCT02343406).
Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera
Authors: Arne Homann, Niels Röckendorf, Arno Kromminga, Andreas Frey, Thomas A Platts-Mills, Uta Jappe
Journal: Theranostics (2017)

Biological drugs like therapeutic antibodies are widely used for the treatment of various diseases like inflammatory disorders and cancer.A drawback of these novel treatments is the substantial proportion of patients experiencing adverse reactions such as loss-of-drug effect or hypersensitivity reactions.These reactions are associated with pre-existing and/or developing anti-drug antibodies.Especially IgE development is a risk factor for life-threatening systemic anaphylaxis.Methods: In order to characterize the individual drug-specific serum IgE, an IgE cross-reactivity immune profiling (ICRIP) assay was developed.Individual IgG epitopes of anti-drug antibodies against adalimumab were identified by epitope mapping via peptide microarray.Results: ICRIP analyses of sera from patients treated with the therapeutic antibodies adalimumab (ADL) and infliximab (IFX) reveal individual, distinct IgE binding patterns.IgG epitopes were identified mostly located in the variable region of ADL.Conclusions: Using ICRIP and peptide microarrays for pharmacovigilance of the TNF-α blockers IFX and ADL, risk factors and biomarkers before and during therapy shall be identified.These diagnostic systems provide the basis for a safe and efficacious therapy decision for each patient in cases of adverse drug reactions mediated by different types of anti-drug antibodies.
Abstract 17441: Social Support is Important, but Self-Care Confidence is the Key for Better Treatment Adherence in Patients With Chronic Heart Failure Admitted With an Acute Exacerbation
Authors: Muna Hammash, Timothy Crawford, Celeste Shawler, Debra Moser
Journal: Circulation (2016)

Introduction: Adherence to treatment is crucial to improve outcomes in patients with heart failure (HF). Social support is associated with adherence, but the mechanism of this association is not we...
PS02.20 Subsequent Therapies Post-Afatinib Among Patients with EGFR Mutation-Positive (EGFRm+) NSCLC in LUX-Lung 3, 6 and 7
Authors: L.V. Sequist, Y. Wu, M. Schuler, T. Kato, J.C. Yang, H. Tanaka, T. Hida, S. Lu, K. Park, L. Paz-Ares, S. Laurie, J. Bennouna, D. Moro Sibilot, A. Märten, W. Tang, E. Ehrnrooth, N. Yamamoto, K. Nakagawa
Journal: Journal of Thoracic Oncology (2017)
The utility of early intervention of palliative care and nutrition support in cancer outpatient's receiving chemotherapy
Authors: Akiko Tanikawa, Naoko Hosono, Yoshiaki Sasagawa, Mika Hayase, Miki Kobayashi, Chihaya Takano, Mayumi Urai, Maiko Kodama, Yasuo Hirono, Katayama Kanji
Journal: Annals of Oncology (2017)
Surgical vs Endoscopic Management of T1 Esophageal Adenocarcinoma: A Modeling Decision Analysis
Authors: Jacqueline N. Chu, Jin Choi, Angela Tramontano, Christopher Morse, David Forcione, Norman S. Nishioka, Julian A. Abrams, Joel H. Rubenstein, Chung Yin Kong, John M. Inadomi, Chin Hur
Journal: Clinical Gastroenterology and Hepatology (2017)
Abstract 15661: Impairment of Thyroid Function in Patients With Fontan Circulation
Authors: Seiko Kuwata, Clara Kurishima, Akiko Yana, Yoichi Iwamoto, Hirofumi Saiki, Hirotaka Ishido, Satoshi Masutani, Hideaki Senzaki
Journal: Circulation (2016)

Background:  An increase in central venous pressure (CVP) and decrease in cardiac output (CI) in Fontan circulation may have adverse effects on thyroid function due to congestion and low perfusion of the thyroid gland. Because thyroid hormones play important roles in the regulation of the cardiovascular system, thyroid dysfunction may be involved in the pathophysiology of Fontan circulation. We investigated the pathophysiological relationships between Fontan hemodynamics and thyroid function.   Methods and Results:  Thirty-seven consecutive patients who had undergone a Fontan operation (median year after the surgery: 4.2 years) had cardiac catheterization and blood tests for thyroid function. One patient treated with amiodarone was excluded from the analysis. Of these, 9 patients (25%) had subclinical thyroid dysfunction defined as elevated thyroid stimulating hormone (TSH) level, but normal thyroid hormone levels. The levels of TSH were significantly correlated with CVP (P 2 =0.3), and patients with subclinical hypothyroidism showed significantly elevated levels of gamma-glutamyl transferase, an indicator of liver congestion, compared to the remaining patients (125.6±12.2 vs. 67.6±4.6 IU/L, P   Conclusion:  Venous congestion in Fontan patients may cause thyroid dysfunction, and impaired thyroid function can be responsible for decreased ventricular function and cardiac output in Fontan patients. These novel findings suggest that thyroid function should be routinely monitored after Fontan surgery, and that thyroid hormone replacement therapy may be an effective treatment option to improve Fontan hemodynamics.