Unraveling the Epidemiology of Oral Human Papillomavirus Infection
Authors: Patti E. Gravitt
Journal: Annals of Internal Medicine (2017)

Editorials21 November 2017Unraveling the Epidemiology of Oral Human Papillomavirus InfectionPatti E. Gravitt, PhD, MSPatti E. Gravitt, PhD, MSGeorge Washington University, Washington DC (P.E.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M17-2628 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The burden of oral cancer in the United States has been evolving for at least 2 decades. Gains in head and neck cancer control afforded by a period effect of reduced tobacco exposure have been displaced by competing cohort effects of increasing sexual exposure to human papillomavirus (HPV) infection and subsequent increases in HPV-associated head and neck cancer, particularly oropharyngeal cancer (1). The male predominance of oropharyngeal cancer in the United States is paralleled by a much higher prevalence of oral HPV infection and a stronger relationship between number of sexual partners and oral HPV prevalence in men than women ...References1. Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011;29:4294-301. [PMID: 21969503] doi:10.1200/JCO.2011.36.4596 CrossrefMedlineGoogle Scholar2. Chaturvedi AK, Graubard BI, Broutian T, Pickard RK, Tong ZY, Xiao W, et al. NHANES 2009-2012 Findings: Association of Sexual Behaviors with Higher Prevalence of Oral Oncogenic Human Papillomavirus Infections in U.S. Men. Cancer Res. 2015;75:2468-77. [PMID: 25873485] doi:10.1158/0008-5472.CAN-14-2843 CrossrefMedlineGoogle Scholar3. Sonawane K, Suk R, Chiao EY, Chhatwal J, Qiu P, Wilkin T, et al. Oral human papillomavirus infection: differences in prevalence between sexes and concordance with genital human papillomavirus infection, NHANES 2011 to 2014. Ann Intern Med. 2017;167:714-24. doi:10.7326/M17-1363 LinkGoogle Scholar4. Patel EU, Rositch AF, Gravitt PE, Tobian AAR. Concordance of Penile and Oral Human Papillomavirus Infections Among Men in the United States. J Infect Dis. 2017;215:1207-1211. [PMID: 28329127] doi:10.1093/infdis/jix116 CrossrefMedlineGoogle Scholar5. Steinau M, Hariri S, Gillison ML, Broutian TR, Dunne EF, Tong ZY, et al. Prevalence of cervical and oral human papillomavirus infections among US women. J Infect Dis. 2014;209:1739-43. [PMID: 24319284] doi:10.1093/infdis/jit799 CrossrefMedlineGoogle Scholar6. Ryser MD, Rositch A, Gravitt PE. Modeling of US Human Papillomavirus (HPV) Seroprevalence by Age and Sexual Behavior Indicates an Increasing Trend of HPV Infection Following the Sexual Revolution. J Infect Dis. 2017;216:604-611. [PMID: 28931221] doi:10.1093/infdis/jix333 CrossrefMedlineGoogle Scholar7. Liu G, Hariri S, Bradley H, Gottlieb SL, Leichliter JS, Markowitz LE. Trends and patterns of sexual behaviors among adolescents and adults aged 14 to 59 years, United States. Sex Transm Dis. 2015;42:20-6. [PMID: 25504296] doi:10.1097/OLQ.0000000000000231 CrossrefMedlineGoogle Scholar8. Gravitt PE. The known unknowns of HPV natural history. J Clin Invest. 2011;121:4593-9. [PMID: 22133884] doi:10.1172/JCI57149 CrossrefMedlineGoogle Scholar9. Liu SH, Cummings DA, Zenilman JM, Gravitt PE, Brotman RM. Characterizing the temporal dynamics of human papillomavirus DNA detectability using short-interval sampling. Cancer Epidemiol Biomarkers Prev. 2014;23:200-8. [PMID: 24130223] doi:10.1158/1055-9965.EPI-13-0666 CrossrefMedlineGoogle Scholar10. Beachler DC, Sugar EA, Margolick JB, Weber KM, Strickler HD, Wiley DJ, et al. Risk factors for acquisition and clearance of oral human papillomavirus infection among HIV-infected and HIV-uninfected adults. Am J Epidemiol. 2015;181:40-53. [PMID: 25480823] doi:10.1093/aje/kwu247 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: George Washington University, Washington DC (P.E.G.)Grant Support: By grant R01 CA190366 from the National Cancer Institute.Disclosures: Author has disclosed no conflicts of interest. Form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-2628.Corresponding Author: Patti E. Gravitt, PhD, MS, Milken Institute School of Public Health, George Washington University, Science and Engineering Hall, 800 22nd Street Northwest, Washington, DC 20052; e-mail, [email protected]edu.This article was published at Annals.org on 17 October 2017. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA clinician’s dilemma: what should be communicated to women with oncogenic genital HPV and their partners regarding the risk of oral viral transmission?Human papillomaviruses: diversity, infection and host interactionsHigh prevalence of human papillomavirus and European variants of HPV 16 infecting concomitantly to cervix and oral cavity in HIV positive women 21 November 2017Volume 167, Issue 10Page: 748-749KeywordsCancer preventionEpidemiologyGenital anatomyHead and neck cancersHealth surveysHuman papillomavirusHuman papillomavirus infectionHuman sexual behaviorNutritionOral health ePublished: 17 October 2017 Issue Published: 21 November 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...