tbuckley/cabot-search huggingface dataset:
Abstract 18668: Integration of Proteomic and Metabolomic Plasma Profiles in a Community-Based Cohort
Authors: Mark D Benson, Dongxiao Shen, Jordan Morningstar, Michelle J Keyes, Deborah Ngo, John O’Sullivan, Xu Shi, Laurie Farrell, Sumita Sinha, Ramachandran S Vasan, Thomas J Wang, Robert E Gerszten
Journal: Circulation (2016)

Introduction:  Circulating proteins and metabolites play key roles as markers and effectors of cardiometabolic diseases. We hypothesized that integrating these data sets may identify novel circulating protein-metabolite associations and provide new insight into molecular pathways that underlie cardiometabolic and vascular disease.   Methods:  Aptamer-based proteomic profiling of 1,129 analytes in plasma samples from 923 Framingham Heart Study Offspring participants (mean age 56 +/- 12 years, 52% women) was performed using the Somascan platform. Targeted metabolomic profiling of 217 analytes was performed by liquid chromatography tandem mass spectrometry, as previously reported. Pearson correlations between log-transformed protein and metabolite concentrations were assessed using PROC CORR in SAS, adjusting for age, sex, and the homeostatic model assessment.   Results:  We identified over 5,000 unadjusted protein-metabolite associations with high levels of significance (Bonferroni-corrected threshold P-value  -7 ). Our analysis identified protein-metabolite relationships known to define key biological pathways. For example, Apolipoprotein E (ApoE) was most highly associated with triacylglyerols (TAGs) of varying fatty acid chain length and degrees of saturation, the most significant of which was a TAG with 50 carbons and 4 double bonds (P=5x10 -48 ). Similarly, thyroid stimulating hormone was most strongly negatively associated with thyroxine (P-value 4x10 -18 ). By contrast, we identified hundreds of novel correlations between plasma levels of metabolites and key cardiometabolic proteins such as Apo E (for example, with the branched chain amino acids valine, P=2x10 -11 ; leucine, P=7x10 -10 ; and isoleucine, P=1x10 -9 ), PCSK9 (with 3-aminoisobutyric acid, P=7x10 -11 ), and adiponectin (with 2-aminoadipic acid, P=1x10 -26 ). These associations remained highly significant when adjusted for age, sex, and insulin resistance.   Conclusions:  The integration of protein and metabolite profiling data sets from large community-based cohorts can be used to identify novel protein-metabolite associations. These associations may offer new tools to elucidate the molecular pathways that underlie cardiometabolic and vascular disease.
Practices’ viability is threatened by Capita’s failings, warns BMA
Authors: Abi Rimmer
Journal: BMJ (2017)

The viability of general practices is threatened by failings by the private company Capita, which provides primary care support services for NHS England, the BMA has warned.

In a letter sent on 30 October to Simon Stevens, chief executive of NHS England, the BMA highlighted what it called Primary Care Services England’s “ongoing issues due to poor delivery” by Capita. However, Capita said that the BMA’s letter did not accurately reflect its role and involvement in providing the services.

Richard Vautrey, chair of the BMA’s general practitioners committee, wrote that significant issues were affecting the practice support system, which had been “causing much distress to practices and putting patients at risk” for over two years.

In the letter, Vautrey said that the BMA was very concerned about preparations for Capita to run new systems for cervical screening and for …
Vigilancia de la resistencia a antibióticos de Salmonella
Authors: A Brisabois, I Cazin, J Breuil, E Collatz
Journal: Eurosurveillance (1997)

Recientemente, la Organizacion Mundial de la Salud destaco el preocupante aumento registrado en la incidencia de cepas de Salmonella resistentes a los antibioticos como consecuencia del uso de antibioticos en la cria intensiva. En Francia, hasta hace pocos anos, no se habia aislado practicamente ningun caso de salmonella resistente a antibioticos en la practica clinica y el tratamiento con antibioticos (no administrado sistematicamente) de la salmonelosis era raramente emprendido. Sin embargo, en las ultimas dos decadas, el centro de serotipia del Centro Nacional de Estudios Veterinarios y Alimentarios (Centre National d'Etudes Veterinaires et Alimentaires -CNEVA-) de Paris ha estudiado la resistencia a los antibioticos de las cepas recibidas. De forma paralela, el CNEVA de Lyon ha establecido una red de vigilancia destinada a controlar la resistencia antimicrobiana de bacterias patogenas comunmente aisladas en el ganado y, en particular, de cepas de salmonella.
Protein Informatics-based analysis of the mechanism of action of Peninsularinone: A novel solid-tumor selective anticancer drug
Authors: Balanehru Subramanian, Joe Media, Alex Nakeff, Frederick Valeriote
Journal: Cancer Research (2006)

1386   The application of data mining and predictions, based on computational biology, of the extensive amount of information generated by proteomic profiling methods, to decipher the mechanism of newly discovered anticancer drug action and study its molecular effects within tumor cells, is novel and challenging. We have developed a strategy termed “Molecular Brushing”, that blends the data generated using PowerBlot™ and relates the protein expression changes to the observed antiproliferative effect of novel anticancer agents. We used this approach to understand the mechanism of Peninsularinone, a novel anticancer agent, initially discovered in our Drug Discovery and Development Program and moving towards clinical trial. Peninsularinone was provided by Dr. James Chesney, Tapestry Pharmaceutiacls, Inc., (Boulder, CO). Proliferating HCT-116 human colon adenocarcinoma cells were treated for 24h with 0.1 μg/ml of Peninsularinone and differential protein expression analysis done against DMSO treated HCT-116 cells. Key drug-modulated proteins were assessed for molecular pathway identification and potential surrogate marker identification. Differential protein expression analysis of 860 proteins was performed using PowerBlot™. Fourteen proteins (1.6%) were up-regulated in their expression levels and thirty-five proteins (4.1%) were down-regulated >1.25 fold from the 3x3 matrix analysis. Proteins were visually plotted into a molecular pathway map and at least six major pathways were identified to be modulated through Peninsularinone’s action at the proteomic level that include: G-protein (receptor) coupled signal transduction, receptor-mediated endocytosis, beta-catenin pathway, Fas/APO-apoptosis, TNF-mediated apoptosis and DNA replication. Protein informatics analysis suggests that Peninsularinone’s anti-proliferative activity is influenced by a decrease in the expression of key proteins involved in cell cycle progression (e.g. Cyclin D, PRb) while those proteins that are mostly increased in their expression (e.g. PKR, Caveolin 1) are involved in enhancing its cytotoxicity. Thus transforming raw experimental data obtained from promising agents into understandable, and computationally-trackable protein interaction networks provides the foundation for accelerated drug discovery and development of novel anticancer agents.
Implementation of Rotavirus Surveillance and Vaccine Introduction — World Health Organization African Region, 2007–2016
Authors: Jason M. Mwenda, Rachel M. Burke, Keith Shaba, Richard Mihigo, Mable Carole Tevi-Benissan, Mutale Mumba, Joseph Nsiari-Muzeyi Biey, Dah Cheikh, Alain Poy, MSc, Felicitas R. Zawaira, Negar Aliabadi, Jacqueline E. Tate, Terri Hyde, Adam L. Cohen, Umesh D. Parashar
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Rotavirus is a leading cause of severe pediatric diarrhea globally, estimated to have caused 120,000 deaths among children aged <5 years in sub-Saharan Africa in 2013 (1). In 2009, the World Health Organization (WHO) recommended rotavirus vaccination for all infants worldwide (2). Two rotavirus vaccines are currently licensed globally: the monovalent Rotarix vaccine (RV1, GlaxoSmithKline; 2-dose series) and the pentavalent RotaTeq vaccine (RV5, Merck; 3-dose series). This report describes progress of rotavirus vaccine introduction (3), coverage (using estimates from WHO and the United Nations Children's Fund [UNICEF]) (4), and impact on pediatric diarrhea hospitalizations in the WHO African Region. By December 2016, 31 (66%) of 47 countries in the WHO African Region had introduced rotavirus vaccine, including 26 that introduced RV1 and five that introduced RV5. Among these countries, rotavirus vaccination coverage (completed series) was 77%, according to WHO/UNICEF population-weighted estimates. In 12 countries with surveillance data available before and after vaccine introduction, the proportion of pediatric diarrhea hospitalizations that were rotavirus-positive declined 33%, from 39% preintroduction to 26% following rotavirus vaccine introduction. These results support introduction of rotavirus vaccine in the remaining countries in the region and continuation of rotavirus surveillance to monitor impact.
TCT-746 Outcomes by Total Stent Length in ACS PCI with Second Generation Drug-Eluting Stents: Results from the PROMETHEUS Study
Authors: Asha Mahajan, Jaya Chandrasekhar, Samantha Sartori, Usman Baber, Birgit Vogel, Sabato Sorrentino, Clayton Snyder, Annapoorna Kini, Sunil Rao, Samir Kapadia, Timothy Henry, Mark Effron, William Weintraub, Sandra Weiss, Craig Strauss, Anthony DeFranco, Catalin Toma, Stuart Keller, Brian Baker, Stuart Pocock, Roxana Mehran
Journal: Journal of the American College of Cardiology (2017)
Abstract #5588: Tumor epidermal growth factor receptor (EGFR) inhibition modulates the tumor microenvironment via vascular normalization and augments chemotherapy and radiotherapy efficacy
Authors: George Cerniglia, Nabendu Pore, Jeffrey Tsai, Chandra Sehgal, William Lee, Amit Maity
Journal: Cancer Research (2009)

Manipulating the tumor microenvironment (TME) to increase perfusion and oxygenation provides a way to enhance tumor response to chemo/radiotherapy. The EGFR inhibitor, erlotinib, decreases tumor expression of hypoxia-inducible factor 1 (HIF-1alpha) and vascular endothelial growth factor (VEGF) in vitro and in vivo. Hypothesizing that these effects of erlotinib on tumor cells and the decrease in VEGF secretion would lead indirectly to vascular normalization and improve tumor oxygenation, we investigated its effects on the TME. Erlotinib treatment of nude mice implanted with human carcinoma xenografts (i) decreased the vascular permeability and altered the morphology of tumor vessels and improved tumor vascular perfusion, and (ii) decreased tumor hypoxia, measured by the nitroimidazole EF5, and increased blood O2 saturation, measured by optical spectroscopy. We predicted these changes would increase chemotherapy delivery and efficacy and improve tumor radiosensitivity. Therefore, we performed tumor regrowth studies using erlotinib and either cisplatin or radiotherapy. Erlotinib followed by cisplatin led to a synergistic delay in tumor growth compared to either treatment by itself, and this sequencing had a much greater effect on tumor growth than did the reverse order. Erlotinib followed by radiation had a greater effect on inhibiting tumor regrowth than did radiation alone, although the effect was not synergistic. Our studies show that targeting tumor cells with EGFR inhibitors and, potentially, other agents, may modulate the TME to improve chemo/radiosensitivity. They have clinical implications about the sequencing and timing of these agents with conventional therapy and suggest ways to monitor their effects on the TME in the clinic using non-invasive imaging.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5588.
TCT-295 Role of OCT in identifying sub-optimal stent positioning and predicting MACE in a head to head comparison with angiography. A CLIO-PCI II sub-study
Authors: Laura Gatto, Marco Golino, Chiara Russo, Valeria Marco, Alessio La Manna, Francesco Burzotta, Massimo Fineschi, Francesco Amico, Alessandro Di Giorgio, Alberto Boi, Enrico Romagnoli, Mario Albertucci, Francesco Prati
Journal: Journal of the American College of Cardiology (2017)
Phase II trial of Panitumumab for patients with KRAS exon2 wild type mCRC after progression on Cetuximab: HGCSG1101
Authors: Ayumu Hosokawa, Satoshi Yuki, Kazuaki Harada, Yasushi Tsuji, Kazuteru Hatanaka, Atsushi Sato, Yoshimitsu Kobayashi, Hiroyuki Okuda, Yuh Sakata, Yoshito Komatsu
Journal: Annals of Oncology (2017)
Immunohaematological complications in patients with sickle cell disease after haemopoietic progenitor cell transplantation: a prospective, single-centre, observational study
Authors: Elizabeth S Allen, Kshitij Srivastava, Matthew M Hsieh, Courtney D Fitzhugh, Harvey G Klein, John F Tisdale, Willy A Flegel
Journal: The Lancet Haematology (2017)
Notice of Retraction. Wansink B, Just DR, Payne CR. Can Branding Improve School Lunches? <i>Arch Pediatr Adolesc Med</i>. 2012;166(10):967-968.
Authors: Brian Wansink, David R. Just, Collin R. Payne
Journal: JAMA Pediatrics (2017)

know this committee proposed that juice should be reduced across WIC food packages to a maximum amount of 64 fluid oz/mo in all packages, except for the package for postpartum women, where the recommendation was to eliminate juice.Moreover, the committee also recommended that the US Department of Agriculture permit WIC participants to elect to receive an additional $3.00 in their cash value voucher instead of juice.This option is cost-neutral and responds to recommendations 3,4 that, as a general practice, fruit should be consumed as whole fruit instead of juice.This option also provides autonomy to WIC participants to meet their personal preferences for juice compared with whole fruit.In summary, the US Department of Agriculture has received recommendations for the contents of the WIC food packages from an expert committee appointed for this purpose.Their proposed recommendations reduce but do not eliminate (except for postpartum women) juice from the food packages.Furthermore, a new option, to exchange the voucher for juice with one for an increase in the cash value voucher to purchase whole fruit, was proposed.
Further implications in analyzing contempt in modern society
Authors: Robert J Sternberg
Journal: Behavioral and Brain Sciences (2017)

Abstract The target article by Gervais &amp; Fessler represents a comprehensive analysis of contempt but is not fully adequate in addressing how contempt produces hatred, how contempt is used manipulatively by aspiring leaders, and how contempt can be cured or at least mitigated. This commentary addresses these concerns.
Epidemiological risk factors for breast cancer recurrence according to estrogen and progesterone receptor status
Authors: Abenaa Brewster, Kim-Anh Do, Patricia Thompson, Karin Hahn, Aysegul Sahin, Yumei Cao, Phyllis Adatto, Melissa Bondy
Journal: Cancer Research (2007)

2609  Breast cancer estrogen receptor (ER) and progesterone receptor (PR) status defines phenotypes of tumors associated with different rates of clinical recurrence. The prognostic significance of epidemiological risk factors in early stage breast cancer according to ER and PR status has not been well evaluated. We utilized a cohort of 2,327 women with early stage breast cancer, treated at a single institution between 1985 and 2000, and evaluated the relationship between breast cancer epidemiological risk factors at diagnosis and 5-year risk of recurrence by ER and PR status. Cox proportional hazard models were used to estimate the hazard ratios (HRs) of recurrence adjusted for treatment, tumor size and lymph node involvement. All statistical tests were two-sided. In univariate analysis, African American ethnicity (p=0.06), age ≤ 50 (p=
Biologic Testing of Carcinogens. I. Subcutaneous-Injection Technique
Authors: Michael B. Shimkin
Journal: JNCI Journal of the National Cancer Institute (1940)

Journal Article Biologic Testing of Carcinogens. I. Subcutaneous-Injection Technique Get access Michael B. Shimkin Michael B. Shimkin assistant surgeon National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 1, Issue 2, October 1940, Pages 211–223, https://doi.org/10.1093/jnci/1.2.211 Published: 01 October 1940
Epidemiology of imaging-detected tendon abnormalities in athletes participating in the Rio de Janeiro 2016 Summer Olympics
Authors: Mohamed Jarraya, Michel D Crema, Lars Engebretsen, Oleg M Teytelboym, Daichi Hayashi, Frank W Roemer, Abdalla Y Skaf, Ali Guermazi
Journal: British Journal of Sports Medicine (2017)

Tendon abnormalities are prevalent among both elite and non-elite athletes. Cross-sectional imaging modalities are used to confirm and evaluate the severity of such lesions.To describe the demographics, prevalence, anatomical location and characteristics of tendon abnormalities in athletes who participated in the Rio de Janeiro 2016 Summer Olympic Games.We recorded all sports injuries reported by the National Olympic Committee (NOC) medical teams and the Organizing Committee medical staff during the Rio 2016 Summer Olympics. Diagnostic imaging was performed through the official IOC clinic within the Olympic Village, using digital ultrasound machines and 3T and 1.5T MR scanners. Image interpretation was performed centrally by board-certified musculoskeletal radiologists with expertise in sports injuries.In total, 11 274 athletes (5089 women (45%), 6185 men (55%)) from 207 NOCs were included. NOC and Rio de Janeiro 2016 medical staff reported 1101 injuries. Central review of radiological images revealed 156 tendon abnormalities in 109 athletes (51.2% male, mean age: 26.8, range 18-39). The supraspinatus tendon was the most commonly involved tendon (31 cases, 19.9%), followed by the Achilles tendon (20 cases, 12.8%) and patellar and infraspinatus tendons (12 cases, 7.7%). Tendon abnormalities were most commonly seen in track and field athletes (54 abnormalities, 34.6%).156 tendon abnormalities were reported, most commonly in track and field athletes, and involving mainly the shoulder tendons, as well as Achilles and patellar tendons.
Online Self-Help as an Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach
Authors: Rüdiger Zwerenz, Jan Becker, Rudolf J. Knickenberg, Martin Siepmann, Karin Hagen, Manfred E. Beutel
Journal: Psychotherapy and Psychosomatics (2017)

Depression is one of the most frequent and costly mental disorders. While there is increasing evidence for the efficacy of online self-help to improve depression or prevent relapse, there is little evidence in blended care settings, especially combined with inpatient face-to-face psychotherapy. Therefore, we evaluated whether an evidence-based online self-help program improves the efficacy of inpatient psychotherapy.A total of 229 depressed patients were randomly allocated either to an online self-help program (intervention group [IG]; Deprexis) or an active control group (CG; weekly online information on depression) in addition to inpatient psychodynamic psychotherapy. Both groups had access to their respective experimental intervention for 12 weeks, regardless of inpatient treatment duration. Reduction of depressive symptoms, as measured with the Beck Depression Inventory-II, was the primary outcome at the end of the intervention (T2).Depressive symptoms were statistically significantly lower in the IG compared to the active CG at T2 with a moderate between-group effect size of d = 0.44. The same applied to anxiety (d = 0.33), quality of life (d = 0.34), and self-esteem (d = 0.38) at discharge from inpatient treatment (T1). No statistically significant differences were found regarding dysfunctional attitudes (d = 0.14) and work ability (d = 0.08) at T1.This is the first evidence for blended treatment combining online self-help with inpatient psychotherapy. The study opens new and promising avenues for increasing the efficacy of inpatient psychotherapy. Future studies should determine how integration of online self-help into the therapeutic process can be developed further.
TCT-26 Orbital Atherectomy Induced Calcium Fracture Facilitates Stent Expansion - An Optical Coherence Tomography Study
Authors: Myong Hwa Yamamoto, Akiko Maehara, Song-Yi Kim, Masaru Ishida, Akiko Fujino, Elizabeth Haag, Dragos Alexandru, Allen Jeremias, Fernando Sosa, Keyvan Karimi Galougahi, Jeffrey W. Moses, Ziad Ali, Gary Mintz, Richard Shlofmitz
Journal: Journal of the American College of Cardiology (2017)
Conjuntivitis epidémica en Alemania, 2004
Authors: A Schrauder, D Altmann, G Laude, H Claus, K Wegner, R Köhler, H Habicht-Thomas, G Krause
Journal: Eurosurveillance (2006)

La conjuntivitis epidemica puede ser relacionada con patogenos virales o bacterianos, mientras que la queratoconjuntivitis es causada principalmente por adenovirus tipo 8, 19 y 37. En Alemania, la incidencia de los casos de conjuntivitis por adenovirus aumento de 0,2 por 100.000 habitantes (en 2001 y 2002) a 0,5 en 2003 y 0,8 en 2004. 
La presencia de adenovirus detectada en las muestras conjuntivales es de declaracion obligatoria a los servicios locales de salud publica. Los datos sobre los casos con muestras conjuntivales positivas se transmiten al instituto Robert-Koch. Estos datos pasan un control de calidad y posteriormente los datos nacionales de vigilancia de los casos confirmados de conjuntivitis por adenovirus son publicados. 
Entre enero y abril de 2004, el sistema nacional de vigilancia detecto un brote de 1.024 casos (de los cuales 131 fueron confirmados por laboratorio). El analisis de los datos nacionales de vigilancia mostro que en marzo de 2004, la queratoconjuntivitis epidemica primero afecto a varones de 18 a 29 anos, seguida por un numero creciente de mujeres del mismo grupo de edad. Durante el mismo periodo, se produjo un brote de conjuntivitis en las Fuerzas armadas alemanas, afectando a 6. 378 soldados, casi todos sin confirmacion microbiologica. 
A pesar del escaso numero de casos confirmados por laboratorio, el analisis de los datos nacionales de vigilancia mostro claramente que habia ocurrido una transmision de persona a persona entre los varones y otras personas del mismo grupo de edad en la poblacion. Tanto si el brote empezo entre los soldados de las Fuerzas armadas alemanas como si comenzo en sus locales, es necesaria la colaboracion entre instituciones nacionales y militares de salud publica para elaborar recomendaciones para los futuros desafios.