tbuckley/cabot-search huggingface dataset:
P341Activation of beta1-integrins and caveolin-1 by TF/FVIIa promotes cell survival
Authors: M Aberg, D Eden, A Siegbahn
Journal: Cardiovascular Research (2018)

Background: Structural and trancriptomic analysis revealed pharmacological heterogeneities of a1-adrenoceptors (a1-ARs), in particular the a1A-and a1D-AR subtypes along the arterial aortic tree.Their stimulations induced the contractile responses to catecholamines.Nitric oxide (NO) released from endothelial cells, key regulator of vascular tone and blood pressure, reduced the contractions to the a1-ARs agonists.Purpose: The present experiments were designed to compare the role of the a1-ARs subtypes in the contractile response to catecholamines in 2 distant parts of the aortic tree as well as to study the role of NO in these responses.Methods: Isometric tension was measured in isolated rings of intact or endothelium denuded thoracic aorta (TA) or abdominal aorta (AA) of Wistar rats.Gene expression was assessed by real-time quantitative PCR.Contractile responses were induced by a non-selective a1-AR agonist, phenylephrine (PHE) and a selective a1A-AR agonist, A61603.Results: a1A-AR and a1D-AR subtypes were expressed in TA and AA while their function was dependent on their localization; however, relative expression of a1D-AR subtype was more important than a1A-AR subtype in both regions.In TA without endothelium, PHE induced doseresponse contractions characterized by a pD2 value (index of vascular reactivity) of 7.9 which was slightly lower in AA (7.3).Moreover, A61603 was more efficient to contract AA than TA as the pD2 was 10 folds higher in AA (6.7 versus 5.4) and close from that of PHE.The selective a1D-AR antagonist, BMY7378, inhibited the contractile responses to PHE in both aortic sites with similar efficacy while the selective a1A-AR antagonist, RS100329, was less effective, indicating that the contraction induced by PHE mainly involved a1D-AR.In contrast, BMY7378 inhibited the contractile response to A61603 in TA, but not in AA, while RS100239 had a limited inhibitory effect on the contraction induced by A61603 in TA, but strongly inhibited those induced on AA.These findings clearly indicated that the a1-adrenergic contractile responses are mainly due to a1D-AR subtype in TA and to a1A-AR subtype in AA.In the presence of endothelium, the contractile responses to PHE were strongly shifted to the right in TA and almost not altered in AA while the responses to A61603 were shifted to the right with a decreased maximal response in TA and were not altered on AA.Thus, the presence of functional endothelium limited the a1-adrenergic contractile response only in TA.A nitric oxide synthase inhibitor, NG-nitro-L-arginine, restored the contractions of both agonists on TA without any change on AA. Conclusion(s):The aortic contractions induced by a1-agonists are mainly supported by a1A-ARs in abdominal aorta and by a1D-ARs in the thoracic aorta.The basal production of endothelial NO only controls the contraction mediated by a1D-ARs in the thoracic aorta.
Different micro-environtmental factors induce proliferation, epithelial-mesenchymal transition (EMT) and senescence of primary cultures of human biliary tree stem/progenitor cells (hBTSCs), recapitulating the pathological features typical of human cholangiopathies
Authors: D. Costantini, G. Carpino, V. Cardinale, D. Overi, L. Nevi, S. Di Matteo, S. Safarikia, F. Melandro, P.B. Berloco, E. Gaudio, D. Alvaro
Journal: Journal of Hepatology (2018)
Different bile acids display distinct ability to trigger Nlrp3 inflammasome activation in a cell-dependent manner contributing to cholestatic liver injury and fibrosis
Authors: M. Inzaugarat, T.M. Holtmann, M. Frissen, L.J. Geisler, J. Reissing, K. Markus Schneider, Z.H. Wolfgang, V. Bieghs, C. Trautwein, A. Wree
Journal: Journal of Hepatology (2018)
Fine tuning of SIRT1 expression is essential to protect the liver from cholestasis
Authors: B. Blokker, M. Maijo, M. Philo, V. Gutierrez, E. Halilbasic, C. Fuchs, G. Legall, M. Milkiewicz, P. Milkiewicz, Jesús Banales, S. Rushbrook, José Matos, M. Trauner, M. Muller, María L. Martínez-Chantar, M. Varela-Rey, N. Beraza
Journal: Journal of Hepatology (2018)
Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity
Authors: Lauren B. Rodda, Erick Lu, Mariko L. Bennett, Caroline L. Sokol, Xiaoming Wang, Sanjiv A. Luther, Ben A. Barres, Andrew D. Luster, Chun Jimmie Ye, Jason G. Cyster
Journal: Immunity (2018)

Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the immune response. However, the full diversity of lymph node (LN) SCs remains undefined. Using droplet-based single-cell RNA sequencing, we identified nine peripheral LN non-endothelial SC clusters. Included are the established subsets, Ccl19
TCTAP A-107 Real World Experience of the Biomime Morph Tapered Stent in a Tertiary Care Hospital
Authors: Sanjai Pattu Valappil, Sunitha Viswanathan, A George Koshy, Prabha Nini Gupta, K. Sivaprasad, V.V. Radhakrishnan, Mathew Iype, M.N. Dilip
Journal: Journal of the American College of Cardiology (2018)
P270Cardiac specific microRNA-125b deficiency impairs mitochondrial function in mouse neonatal and adult heart
Authors: C Y Chen, D S Lee, P C Hsieh
Journal: Cardiovascular Research (2018)

glibenclamide group (n¼11) spontaneously defibrillated within the time analyzed (v 2 (2)¼26,456, p<0.001).Conclusion: Activation of IKATP exerts arrhythmogenic and deleterious electrophysiological effects during normoxia and ischemic conditions.Blockade of KATP channels during ischemia has shown antiarrythmic properties.The electrophysiological effects of training on the events analyzed do not seem to be mediated by KATP opening.Further research must be taken in order to clarify the role of KATP chanels in the protective mechanisms elicited by physical training.
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
Authors: Bjoern Chapuy, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, Margaretha G. M. Roemer, Amy J. Li, Marita Ziepert, Annette M. Staiger, Jeremiah A. Wala, Matthew D. Ducar, Ignaty Leshchiner, Ester Rheinbay, Amaro Taylor-Weiner, Caroline A. Coughlin, Julian M. Hess, Chandra S. Pedamallu, Dimitri Livitz, Daniel Rosebrock, Mara Rosenberg, Adam A. Tracy, Heike Horn, Paul van Hummelen, Andrew L. Feldman, Brian K. Link, Anne J. Novak, James R. Cerhan, Thomas M. Habermann, Reiner Siebert, Andreas Rosenwald, Aaron R. Thorner, Matthew L. Meyerson, Todd R. Golub, Rameen Beroukhim, Gerald G. Wulf, German Ott, Scott J. Rodig, Stefano Monti, Donna S. Neuberg, Markus Loeffler, Michael Pfreundschuh, Lorenz Trümper, Gad Getz, Margaret A. Shipp
Journal: Nature Medicine (2018)
The EPoS staging system is a reproducible 7-tierfibrosis score for NAFLD adapted both to glass slides and digitized images (e-slides)
Authors: P. Bedossa, J. Arola, D. Susan, A.S. Gouw, G. Maria, K. Lackner, P. Schirmacher, L.M. Terracciano, Q. Anstee, V. Ratziu, T. Dina
Journal: Journal of Hepatology (2018)
Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin
Authors: Yankai Wen, Chenchen Wang, Jinyang Gu, Chang Yu, Kaixia Wang, Xuehua Sun, Yun Sun, Hailong Wu, Ying Tong, Qiang Xia, Xiaoni Kong
Journal: Cellular and Molecular Immunology (2018)
Inconsistent availability of hearing aids during acute admission
Authors: Michael W Mather, Nicholas Dawe, Janet Wilson
Journal: BMJ (2018)

Blustein and colleagues discuss the challenges faced by hearing impaired patients in busy acute healthcare settings.1 Receptive communication deficiency affects shared decision making, particularly in vulnerable patients. Hearing loss is independently associated with accelerated cognitive decline.2

As otolaryngology doctors, we were keen to clarify the current availability of assistive devices. A brief survey of 14 …
The Cost of Diabetes Care—An Elephant in the Room
Authors: Matthew C. Riddle, William H. Herman
Journal: Diabetes Care (2018)

Everyone dealing with health care today knows there is an elephant in the room, impossible to miss but frequently ignored—the cost of diabetes care. Although clinicians and scientists may wish to neglect the financial side of diabetes care and focus on less contentious and more familiar matters, this option is no longer viable. For people with diabetes and their families, the elephant stands in the way every day, and for those who plan health services and payment, it is a major concern. Fortunately, the scientific methods used in epidemiologic, clinical, and health services research can be applied to the economics of diabetes care. Collecting observations, identifying patterns, forming hypotheses, and prospectively testing the hypotheses can be just as relevant when one of the variables examined is the cost of care. It is the mission of Diabetes Care to present the best scientific studies related to diabetes. This issue of Diabetes Care has a special section focused on the economic impact of diabetes, including studies designed to understand it and to assess potential solutions.

The American Diabetes Association (ADA) has previously reported the costs of diabetes in the U.S. for the years 2002 (1), 2007 (2), and 2012 (3). This issue of Diabetes Care includes a 2017 update (4). Because the methods used in these analyses are similar, comparisons are possible. The most noteworthy findings from the current report are the continuing increase and the remarkable magnitude of the total direct costs of diabetes in the U.S.: $116 billion in 2007, $176 billion in 2012, and $237 billion in 2017. The cost of care for people with diabetes now accounts for ∼1 in 4 health care dollars spent in the U.S. Care for a person with diabetes now costs an average of $16,752 per year. As in prior reports, the 2017 …
Abstract 12953: Serum Thrombospondin-2 Levels Correlate with Disease Severity and Predict Mortality in Patients with Heart Failure with Preserved Ejection Fraction
Authors: Yuichi Kimura, Yasuhiro Izumiya, Shinsuke Hanatani, Eiichiro Yamamoto, Hiroaki Kusaka, Takanori Tokitsu, Taku Rokutanda, Satoshi Araki, Hisao Ogawa
Journal: Circulation (2013)

Introduction:  Thrombospondin-2 (TSP-2) is a matricellular protein and its expression is increased in hypertensive heart. Interstitial fibrosis is frequently observed in hypertensive heart, and it is one of the histological characteristics of heart failure with preserved ejection fraction (HFpEF).   Hypothesis:  TSP-2 reflects disease severity and predicts mortality in patients with HFpEF.   Methods and results:  We measured serum TSP-2 levels in 129 patients with HFpEF. HFpEF was defined as an left ventricular ejection fraction equal or greater than 50%, BNP≧100pg/ml or E/e’≧15. Serum TSP-2 concentrations were measured by ELISA. The endpoints of this study were composed of total mortality, fatal arrhythmia, HF hospitalization, and stroke. These patients were divided into 2 groups according to the TSP-2 levels. Median TSP-2 levels in each group were 13.72 ng/ml and 24.93 ng/ml, respectively. High TSP-2 group showed significantly higher BNP [median 171.0, interquartile range (58.8-296.6) vs. 53.5, (19.5-96.6) pg/ml, p≤0.0001], mean pulmonary capillary wedge pressure [12.0, (9.0-15.0) vs. 9.0, (7.0-12.0) mg/l, p=0.002] than those with low TSP-2 group. Serum TSP-2 levels were positively correlated with NYHA functional class in this study population (p≤0.0001). Kaplan Meier curve revealed that the event-free rate was decreased in the high TSP-2 group (log-rank test p=0.005). Multiple Cox regression analysis identified NYHA (hazard ratio [HR]: 4.11; confidence interval [CI]: 1.66-10.22, p=0.002), diabetes mellitus (HR: 0.17; CI: 0.04-0.75, p=0.02), atrial fibrillation (HR: 4.78; CI: 1.48-15.39, p = 0.009), dyslipidemia (HR: 11.22; CI: 1.19-106.04, p = 0.02), and TSP-2 (HR: 7.38; CI: 2.30-23.67, p = 0.001) as independent predictors for primary end point.   Conclusions:  Circulating TSP-2 correlates with disease severity in patients with HFpEF. TSP-2 could be a useful biomarker to predict future adverse cardiovascular events in patients with HFpEF.
Epidemic of flesh eating tropical ulcers hits Australia
Authors: Ingrid Torjesen
Journal: BMJ (2018)

Australia is facing a “rapidly worsening epidemic” of flesh eating ulcers, known as Buruli ulcers, which are most commonly seen in tropical regions of West or Central Africa.

Around 2000 cases of Buruli ulcers are reported worldwide each year. In Australia, 95 cases were reported in the Daintree area of northern Queensland between 2009 and 2015, and a few cases have been reported in other parts of Queensland, the Northern Territory, and New South Wales. But the increasing numbers are predominantly being seen in “temperate” rural areas in the state of Victoria.

In 2016, there were 182 cases in Victoria—the highest ever reported. By 11 November 2017, 216 had been reported in …
Inspection—A Fine Art
Authors: Vijay Kumari Sandhu
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Precision medicine targeting disrupted IGF signaling in hepatoblastoma
Authors: O. Kuchuk, N. Akers, D. Sia, M. Simon-Coma, J. Carrillo, I. Martinez-Quetglas, M. Gambato, L. Royo, S. Yoo, M.-A. Buendia, S. Cairo, J. Zhu, V. Mazzaferro, B. Losic, C. Armengol, J. Llovet
Journal: Journal of Hepatology (2018)
Abstract IA23: Allele-specific HLA loss and immune escape in lung cancer evolution
Authors: Nicholas McGranahan, Rachel Rosenthal, Crispin T. Hiley, Andrew J. Rowan, Thomas B.K. Watkins, Gareth A. Wilson, Nicolai J. Birkbak, Selvaraju Veeriah, Peter Van Loo, Javier Herrero, Charles Swanton
Journal: Clinical Cancer Research (2018)

Abstract In order to avoid immune predation, particularly in response to immunotherapy, tumors must acquire mechanisms to evade immune detection or withstand its activity. Disruption of human leukocyte antigen (HLA), which may lead to reduced neoantigen presentation, has been proposed as an immune escape strategy in many cancers, including lung cancer. A high proportion of cancer types have been found to downregulate HLA expression, potentially leading to the evasion of T cell-mediated destruction (Hicklin, 1999; Garrido, 2017) with reduced HLA expression associating with decreased overall survival and tumor progression (Mehta, 2008). Another irreversible means of HLA disruption is via loss of heterozygosity (LOH) at the HLA locus (Koopman, 2000). However, to date, the diversity of the HLA locus has impeded copy number analysis and determination of HLA loss. To investigate the prevalence, timing, and importance of HLA disruption, we developed LOHHLA (Loss Of Heterozygosity in Human Leukocyte Antigen), a computational tool to determine HLA allele-specific copy number from sequencing data. Supporting the notion that loss of antigen presentation may play an important role in immune evasion during tumor evolution, HLA LOH was identified in 40% of the NSCLC samples analyzed, frequently as a late event in tumor evolution and associated with a high subclonal neoantigen burden, increase in immune infiltration, and PD-L1 positivity. Characterizing HLA haplotype specific copy number with LOHHLA refines neoantigen prediction and may have implications for immunotherapeutic approaches targeting neoantigens. Citation Format: Nicholas McGranahan, Rachel Rosenthal, Crispin T. Hiley, Andrew J. Rowan, Thomas B.K. Watkins, Gareth A. Wilson, Nicolai J. Birkbak, Selvaraju Veeriah, Peter Van Loo, Javier Herrero, Charles Swanton. Allele-specific HLA loss and immune escape in lung cancer evolution [abstract]. In: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; Jan 8-11, 2018; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(17_Suppl):Abstract nr IA23.
The clinical significance of oropharyngeal cultures in young children with cystic fibrosis
Authors: Oded Breuer, Daan Caudri, Lauren Akesson, Sarath Ranganathan, Stephen M. Stick, André Schultz
Journal: European Respiratory Journal (2018)

In children with cystic fibrosis (CF) the associations between oropharyngeal swabs (OPSs) for detection of Pseudomonas and lung disease have not been evaluated. OPS and bronchoalveolar lavage (BAL) samples were obtained annually in children with CF from 2005 to 2017. OPS test characteristics were calculated using BAL as “gold standard”. Results were related to lung inflammation (BAL neutrophil elastase and interleukin-8), structural lung disease (chest computed tomography PRAGMA-CF (Perth–Rotterdam Annotated Grid Morphometric Analysis for CF) scores), respiratory exacerbations and future detection of Pseudomonas on BAL. From 181 patients, 690 paired OPS–BAL cultures were obtained. Prevalence of Pseudomonas in BAL was 7.4%. OPS sensitivity was 23.0% and specificity was 91.4%, reducing the post-test probability for a positive BAL following a negative OPS to 6.3%. Pseudomonas on OPS was not associated with lung inflammation or respiratory exacerbations, but was weakly associated with current PRAGMA-CF %Disease score (p=0.043). Pseudomonas on BAL was associated with positive neutrophil elastase (OR 4.17, 95% CI 2.04–8.53; p&lt;0.001), increased interleukin-8 (p&lt;0.001), increased all baseline PRAGMA computed tomography scores (p&lt;0.001), progression of PRAGMA computed tomography scores (p&lt;0.05) and increased risk of respiratory exacerbations (incidence rate ratio 2.11, 95% CI 1.15–3.87; p=0.017). In children with CF OPSs only marginally change the probability of detecting lower airway Pseudomonas and are not associated with lung disease indices nor exacerbations risk.
Endoscopic ultrasound-guided radiofrequency ablation for management of benign solid pancreatic tumors
Authors: Jun-Ho Choi, Dong-Wan Seo, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Sung Koo Lee, Myung-Hwan Kim
Journal: Endoscopy (2018)

Abstract Background Radiofrequency ablation (RFA) has been increasingly employed in experimental and clinical settings for the management of pancreatic lesions. This study aimed to assess the safety and efficacy of endoscopic ultrasound (EUS)-guided RFA for benign solid pancreatic tumors. Methods In a single-center, prospective study, 10 patients with benign solid pancreatic tumors underwent EUS-RFA. After the RFA electrode had been inserted into the pancreatic mass, the radiofrequency generator was activated to deliver 50 W of ablation power. Results Among the 10 patients, 16 sessions of EUS-RFA were successfully performed. Diagnoses included nonfunctioning neuroendocrine tumor (n = 7), solid pseudopapillary neoplasm (n = 2), and insulinoma (n = 1); the median largest diameter of the tumors was 20 mm (range 8 – 28 mm). During follow-up (median 13 months), radiologic complete response was achieved in seven patients. Two adverse events (12.4 %; 1 moderate and 1 mild) occurred. Conclusions EUS-RFA may be a safe and potentially effective treatment option in selected patients with benign solid pancreatic tumors. Multiple sessions may be required if there is a remnant tumor, and adverse events must be carefully monitored.
Stk25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and NAFLD in mice
Authors: M. Mahlapuu, E.N. Duran, M. Aghajan, M. Amrutkar, S. Sütt, E. Cansby, S. Booten, A. Watt, M. Ståhlman, N. Stefan, H.-U. Haering, H. Staiger, J. Boren, H.-U. Marschall
Journal: Journal of Hepatology (2018)
Cirrhotic Cardiomyopathy After Transplantation: Neither the Transient Nor Innocent Bystander
Authors: Manhal Izzy, Jae Oh, Kymberly D. Watt
Journal: Hepatology (2018)

Cirrhotic cardiomyopathy in end-stage liver disease is currently characterized by blunted contractile systolic response to stress with or without diastolic dysfunction in the absence of known heart disease. Since the establishment of the diagnostic criteria of cirrhotic cardiomyopathy in 2005, there have been multiple studies regarding its pathophysiology and pretransplant clinical course. The data regarding the post-transplant course of this entity are sparse. This review addresses the course and prognosis of the elements of cirrhotic cardiomyopathy after liver transplantation (LT). To this end, there is limited compelling evidence demonstrating the reversibility of this entity post-LT. Cirrhotic cardiomyopathy may, in fact, increase the risk of post-transplant complications. This review reveals a need to refine the diagnostic criteria of cirrhotic cardiomyopathy in view of the remarkable progress in the sphere of echocardiographic evaluation of systolic and diastolic dysfunction. The post-transplant course and outcomes related to cirrhotic cardiomyopathy may be better evaluated in the setting of updated diagnostic criteria.
Neutral Theory in Cancer Cell Population Genetics
Authors: Atsushi Niida, Watal M Iwasaki, Hideki Innan
Journal: Molecular Biology and Evolution (2018)

Kimura's neutral theory provides the whole theoretical basis of the behavior of mutations in a Wright–Fisher population. We here discuss how it can be applied to a cancer cell population, in which there is an increasing interest in genetic variation within a tumor. We explain a couple of fundamental differences between cancer cell populations and asexual organismal populations. Once these differences are taken into account, a number of powerful theoretical tools developed for a Wright–Fisher population could be readily contribute to our deeper understanding of the evolutionary dynamics of cancer cell population.
Maternal Sirolimus Therapy for Fetal Cardiac Rhabdomyomas
Authors: Benjamin T Barnes, David Procaccini, Jude Crino, Karin Blakemore, Priya Sekar, Katelynn G Sagaser, Angie C Jelin, Lasya Gaur
Journal: New England Journal of Medicine (2018)

Maternal Sirolimus for Fetal Cardiac Rhabdomyomas Cardiac rhabdomyomas were diagnosed in a fetus at 21 weeks of gestation by means of echocardiography; probable tuberous sclerosis complex was diagnosed by association. The mother received sirolimus, with considerable regression of the cardiac tumors in utero.
Incidence and outcome of portal vein thrombosis in HCV cirrhotic patients treated with direct-acting antivirals: a single-center prospective 3-year study
Authors: E. Degasperi, G. Tosetti, R. D’ambrosio, A. Aghemo, M. Borghi, R. Soffredini, M. Primignani, P. Lampertico
Journal: Journal of Hepatology (2018)