tbuckley/cabot-search huggingface dataset:
Prevenção da transmissão dos Staphylococcus aureus resistentes à meticilina na população geral
Authors: F Vandenesch, J Etienne
Journal: Eurosurveillance (2004)

Durante os ultimos 20 a 30 anos, as estirpes de Staphylococcus aureus resistentes a meticilina (SARM) tem sido presentes nos hospitais, convertindo-se numa das principais causas de infeccoes nosocomiais. A taxa de resistencia a meticilina dos S. Aureus varia consideravelmente de um pais a outro, tendo os Estados Unidos e o sul da Europa uma prevalencia alta (g20%) e o Norte da Europa uma prevalencia baixa (l =5%). Os SARM adquiridos na comunidade (CA-SARM) emergiram no mundo inteiro no final dos anos 1990. Houve muita confusao de literatura entre as infeccoes por SARM associadas a cuidados sanitarios na populacao geral em pacientes a risco para infeccoes nosocomiais a SARM (como os pacientes com historia de hospitalisacao no passado, apresentando uma deficiencia immunitaria, etc.), e as verdadeiras infeccoes CA-SARM devidas as estirpes presentes unicamente na comunidade.
Vascular Reactions of Normal and Malignant Tissues in Vivo. II. The Vascular Reaction of Normal and Neoplastic Tissues of Mice to A Bacterial Polysaccharide from Serratia Marcescens (Bacillus Prodigiosus) Culture Filtrates&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Glenn H. Algire, Frances Y. Legallais, Helen D. Park
Journal: JNCI Journal of the National Cancer Institute (1947)

Vascular Reactions of Normal and Malignant Tissues in Vivo. II. The Vascular Reaction of Normal and Neoplastic Tissues of Mice to A Bacterial Polysaccharide from Serratia Marcescens (Bacillus Prodigiosus) Culture Filtrates Get access Glenn H. Algire, Glenn H. Algire Search for other works by this author on: Oxford Academic PubMed Google Scholar Frances Y. Legallais, Frances Y. Legallais Search for other works by this author on: Oxford Academic PubMed Google Scholar Helen D. Park Helen D. Park National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 8, Issue 2, October 1947, Pages 53–62, https://doi.org/10.1093/jnci/8.2.53 Published: 01 October 1947 Article history Received: 22 July 1947 Published: 01 October 1947
TCT-699 Percutaneous Intervention for Concurrent Chronic Total Occlusions in Patients with ST-Elevation Myocardial Infarction: A systematic Review and Meta-analysis.
Authors: Pedro Villablanca, Wilman Olmedo, Michael Weinreich, Divyanshu Mohananey, Tanush Gupta, Cristina Sanina, Muhammad Farooq, Emily Ong, Thomas Brevik, Diego Castellon, Harish Ramakrishna, Mario Garcia, Robert Pyo, Mark Menegus, Anna Bortnick, Jose Wiley
Journal: Journal of the American College of Cardiology (2017)
Dynamics of gene silencing during X inactivation using allele-specific RNA-seq (vol 16, 149, 2015)
Authors: H. Marks, H.H.D. Kerstens, T.S. Barakat, E. Splinter, R.A.M. Dirks, G. van Mierlo, O.K. Joshi, S. Wang, T. Babak, C.A. Albers, T. Kalkan, A. Smith, A. Jouneau, W. de Laat, J. Gribnau, H.G. Stunnenberg
Journal: Genome biology (2016)
Erratum: Corrigendum: The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
Authors: Jing Geng, Shujuan Yu, Hao Zhao, Xiufeng Sun, Xun Li, Ping Wang, Xiaolin Xiong, Lixin Hong, Changchuan Xie, Jiahui Gao, Yiran Shi, Jiaqi Peng, Randy L Johnson, Nengming Xiao, Linrong Lu, Jiahuai Han, Dawang Zhou, Lanfen Chen
Journal: Nature Immunology (2017)
Surveillance de la cryptosporidiose et des maladies transmises par l’eau en Europe
Authors: J C Semenza, G Nichols
Journal: Eurosurveillance (2007)

La bacterie Cryptosporidium provoque des episodes diarrheiques pouvant etre particulierement graves chez les personnes immunodeprimees. La cryptosporidiose est une maladie a declaration obligatoire dans l’Union europeenne et les donnees de surveillance sont recueillies via le reseau de surveillance europeen.
TCT-110 Peri-procedural Myocardial Infarction and Mortality in Patients Undergoing PCI vs. CABG for Left Main Disease: Analysis from the EXCEL Trial
Authors: Ori Ben-Yehuda, Thomas McAndrew, Shmuel Chen, Bjorn Redfors, Ioanna Kosmidou, David Kandzari, Marie-Claude Morice, Martin Leon, William Brown, Ovidiu Dressler, A. Pieter Kappetein, Joseph Sabik, Patrick Serruys, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Above and below the surface: Genetic and cultural factors in the development of values
Authors: Sara Dellantonio, Luigi Pastore, Gianluca Esposito
Journal: Behavioral and Brain Sciences (2017)

Abstract In the Attitude–Scenario–Emotion (ASE) model, social relationships are subpersonnally realized by sentiments: a network of emotions/attitudes representing relational values. We discuss how relational values differ from moral values and raise the issue of their ontogeny from genetic and cultural factors. Because relational values develop early in life, they cannot rely solely on cognition as suggested by the notion of attitude.
Are the odds shifting against pharma in the fight for cheaper treatment for macular degeneration?
Authors: Deborah Cohen
Journal: BMJ (2017)

Doctors plan to prescribe bevacizumab despite legal threats from drug companies, and against GMC and NICE guidance. Responses to the policy and new legal rulings hint at a turning point in a long-running battle in which £0.5bn potential NHS savings are at stake, reports <b>Deborah Cohen</b>
Tissue-Resident Lymphocytes in the Kidney
Authors: Jan-Eric Turner, Martina Becker, Hans-Willi Mittrücker, Ulf Panzer
Journal: Journal of the American Society of Nephrology (2017)

It has become evident that nonlymphoid tissues are populated by distinct subsets of innate and adaptive lymphocytes that are characterized by minimal exchange with recirculating counterparts. Especially at barrier sites, such as the skin, gut, and lung, these tissue-resident lymphocyte populations are ideally positioned to quickly respond to pathogens and other environmental stimuli. The kidney harbors several classes of innate and innate-like lymphocytes that have been described to contribute to this tissue-resident population in other organs, including innate lymphoid cells, natural killer cells, natural killer T cells, mucosal-associated invariant T cells, and γδ T cells. Additionally, a substantial proportion of the adaptive lymphocytes that are found in the kidney displays a surface phenotype suggestive of tissue residency, such as CD69+CD4+ T cells. In this review, we summarize recent advances in the understanding of tissue-resident lymphocyte populations, review the available evidence for the existence of these populations in the kidney, and discuss the potential physiologic and pathophysiologic roles thereof in kidney.
Epidémie d’infections à Clostridium histolyticum chez les utilisateurs de drogues injectables en Angleterre et en Ecosse
Authors: J S Brazier, M Gal, V Hall, T E Morris
Journal: Eurosurveillance (2004)

Les infections a clostridium chez les utilisateurs de drogues injectables au Royaume-Uni representent un phenomene relativement recent qui est apparu en 2000 avec l’identification de cas severes et de deces dus a Clostridium novyi. Entre decembre 2003 et avril 2004, le laboratoire de reference des anaerobies a recu douze isolats d’un pathogene extremement rare, Clostridium histolyticum, preleves chez des utilisateurs de drogues injectables. Les prelevements provenaient de neuf hopitaux differents en Angleterre et en Ecosse. Le typage moleculaire des isolats par deux methodes differentes d’electrophorese en champ pulse et le ribotypage par PCR ont montre qu’ils etaient indiscernables. Ces resultats sont en faveur d’une source commune des infections, probablement un arrivage d’heroine qui a circule recemment au Royaume-Uni.
Efficacy and Safety of Digital Single-Operator Cholangioscopy for Difficult Biliary Stones
Authors: Olaya I. Brewer Gutierrez, Noor L.H. Bekkali, Isaac Raijman, Richard Sturgess, Divyesh V. Sejpal, Hanaa D. Aridi, Stuart Sherman, Raj J. Shah, Richard S. Kwon, James L. Buxbaum, Claudio Zulli, Wahid Wassef, Douglas G. Adler, Vladimir Kushnir, Andrew Y. Wang, Kumar Krishnan, Vivek Kaul, Demetrios Tzimas, Christopher J. DiMaio, Sammy Ho, Bret Petersen, Jong Ho Moon, B. Joseph Elmunzer, George J.M. Webster, Yen-I. Chen, Laura K. Dwyer, Summant Inamdar, Vanessa B. Patrick, Augustin Attwell, Amy Hosmer, Christopher Ko, Attilio Maurano, Avik Sarkar, Linda J. Taylor, Martin H. Gregory, Daniel S. Strand, Ali Raza, Shivangi Kothari, Jessica P. Harris, Nikhil A. Kumta, Amar Manvar, Mark D. Topazian, Yun Nah Lee, Clayton M. Spiceland, Arvind J. Trindade, Majidah A. Bukhari, Omid Sanaei, Saowanee Ngamruengphong, Mouen A. Khashab
Journal: Clinical Gastroenterology and Hepatology (2017)
Association of Tumor Necrosis Factor Inhibitor Treatment With Reduced Indices of Subclinical Atherosclerosis in Patients With Psoriatic Disease
Authors: Lihi Eder, Aditya A. Joshi, Amit K. Dey, Richard Cook, Evan L. Siegel, Dafna D. Gladman, Nehal N. Mehta
Journal: Arthritis & Rheumatology (2017)

Objective To assess the effect of tumor necrosis factor inhibitors ( TNF i) on subclinical cardiovascular disease in patients with psoriatic disease. Methods We performed a 2‐stage study. In stage 1, carotid total plaque area was assessed in patients with psoriasis or psoriatic arthritis (PsA) (n = 319) by ultrasound at baseline and after 2–3 years. The annual progression rate of atherosclerosis was the outcome of interest. In stage 2, PsA patients receiving TNF i (n = 21) and age‐ and sex‐matched PsA patients not receiving any biologic agent (n = 13) underwent 18 F‐fluorodeoxyglucose–positron emission tomography/computed tomography at baseline and 1 year to assess vascular inflammation, measured as target‐to‐background ratio ( TBR ). In both stages, multivariable regression analyses adjusted for cardiovascular risk factors and use of statins were performed. Results In stage 1, men had significantly higher atherosclerosis progression than women ( P &lt; 0.001). TNF i was associated with reduced atherosclerosis progression in men after controlling for cardiovascular risk and use of statins (adjusted β = −2.20 [95% confidence interval −3.41, −1.00], P &lt; 0.001). There was no association between TNF i and atherosclerosis progression in women ( P = 0.74). In stage 2, patients receiving TNF i had reduced TBR at 1 year ( P = 0.03). Those not receiving TNF i had no significant change in TBR ( P = 0.32). The improvement in aortic vascular inflammation in the TNF i group was independent of cardiovascular risk factors (adjusted β = −0.41 [95% confidence interval −0.74, −0.08], P = 0.02). Conclusion Our findings indicate that TNF i treatment is associated with reduced progression of carotid plaques in men and improvement in vascular inflammation in both men and women with psoriatic disease.
Evidence-Based Guidelines to Eliminate Repetitive Laboratory Testing
Authors: Kevin P. Eaton, Kathryn Levy, Christine Soong, Amit K. Pahwa, Christopher Petrilli, Justin B. Ziemba, Hyung J. Cho, Rodrigo Alban, Jaime F. Blanck, Andrew S. Parsons
Journal: JAMA Internal Medicine (2017)

Routine daily laboratory testing of hospitalized patients reflects a wasteful clinical practice that threatens the value of health care. Choosing Wisely initiatives from numerous professional societies have identified repetitive laboratory testing in the face of clinical stability as low value care. Although laboratory expenditure often represents less than 5% of most hospital budgets, the impact is far-reaching given that laboratory tests influence nearly 60% to 70% of all medical decisions. Excessive phlebotomy can lead to hospital-acquired anemia, increased costs, and unnecessary downstream testing and procedures. Efforts to reduce the frequency of laboratory orders can improve patient satisfaction and reduce cost without negatively affecting patient outcomes. To date, numerous interventions have been deployed across multiple institutions without a standardized approach. Health care professionals and administrative leaders should carefully strategize and optimize efforts to reduce daily laboratory testing. This review presents an evidence-based implementation blueprint to guide teams aimed at improving appropriate routine laboratory testing among hospitalized patients.
Phenotype and Clinical Outcomes of Titin Cardiomyopathy
Authors: Upasana Tayal, Simon Newsome, Rachel Buchan, Nicola Whiffin, Brian Halliday, Amrit Lota, Angharad Roberts, A. John Baksi, Inga Voges, Will Midwinter, Alijca Wilk, Risha Govind, Roddy Walsh, Piers Daubeney, Julian W.E. Jarman, Resham Baruah, Michael Frenneaux, Paul J. Barton, Dudley Pennell, James S. Ware, Sanjay K. Prasad, Stuart A. Cook
Journal: Journal of the American College of Cardiology (2017)

Improved understanding of dilated cardiomyopathy (DCM) due to titin truncation (TTNtv) may help guide patient stratification.The purpose of this study was to establish relationships among TTNtv genotype, cardiac phenotype, and outcomes in DCM.In this prospective, observational cohort study, DCM patients underwent clinical evaluation, late gadolinium enhancement cardiovascular magnetic resonance, TTN sequencing, and adjudicated follow-up blinded to genotype for the primary composite endpoint of cardiovascular death, and major arrhythmic and major heart failure events.Of 716 subjects recruited (mean age 53.5 ± 14.3 years; 469 men [65.5%]; 577 [80.6%] New York Heart Association function class I/II), 83 (11.6%) had TTNtv. Patients with TTNtv were younger at enrollment (49.0 years vs. 54.1 years; p = 0.002) and had lower indexed left ventricular mass (5.1 g/m2 reduction; padjusted = 0.03) compared with patients without TTNtv. There was no difference in biventricular ejection fraction between TTNtv+/- groups. Overall, 78 of 604 patients (12.9%) met the primary endpoint (median follow-up 3.9 years; interquartile range: 2.0 to 5.8 years), including 9 of 71 patients with TTNtv (12.7%) and 69 of 533 (12.9%) without. There was no difference in the composite primary outcome of cardiovascular death, heart failure, or arrhythmic events, for patients with or without TTNtv (hazard ratio adjusted for primary endpoint: 0.92 [95% confidence interval: 0.45 to 1.87]; p = 0.82).In this large, prospective, genotype-phenotype study of ambulatory DCM patients, we show that prognostic factors for all-cause DCM also predict outcome in TTNtv DCM, and that TTNtv DCM does not appear to be associated with worse medium-term prognosis.
Prostate Cancer Patient Characteristics Associated With a Strong Preference to Preserve Sexual Function and Receipt of Active Surveillance
Authors: James R Broughman, Ramsankar Basak, Matthew E Nielsen, Bryce B Reeve, Deborah S Usinger, Kiayni C Spearman, Paul A Godley, Ronald C Chen
Journal: JNCI Journal of the National Cancer Institute (2017)

Men with early-stage prostate cancer have multiple options that have similar oncologic efficacy but vary in terms of their impact on quality of life. In low-risk cancer, active surveillance is the option that best preserves patients' sexual function, but it is unknown if patient preference affects treatment selection. Our objectives were to identify patient characteristics associated with a strong preference to preserve sexual function and to determine whether patient preference and baseline sexual function level are associated with receipt of active surveillance in low-risk cancer.In this population-based cohort of men with localized prostate cancer, baseline patient-reported sexual function was assessed using a validated instrument. Patients were also asked whether preservation of sexual function was very, somewhat, or not important. Prostate cancer disease characteristics and treatments received were abstracted from medical records. A modified Poisson regression model with robust standard errors was used to compute adjusted risk ratio (aRR) estimates. All statistical tests were two-sided.Among 1194 men, 52.6% indicated a strong preference for preserving sexual function. Older men were less likely to have a strong preference (aRR = 0.98 per year, 95% confidence interval [CI] = 0.97 to 0.99), while men with normal sexual function were more likely (vs poor function, aRR = 1.59, 95% CI = 1.39 to 1.82). Among 568 men with low-risk cancer, there was no clear association between baseline sexual function or strong preference to preserve function with receipt of active surveillance. However, strong preference may differnetially impact those with intermediate baseline function vs poor function (Pinteraction = .02).Treatment choice may not always align with patients' preferences. These findings demonstrate opportunities to improve delivery of patient-centered care in early prostate cancer.
Frequency and significance of indeterminate and borderline Quantiferon Gold TB IGRA results
Authors: James Brown, Kartik Kumar, Jacob Reading, Jennifer Harvey, Saraswathi Murthy, Santino Capocci, Susan Hopkins, Suranjith Seneviratne, Ian Cropley, Marc Lipman
Journal: European Respiratory Journal (2017)

The Quantiferon Gold test is one of two commercially available tuberculosis (TB) interferon-γ release assays (IGRAs) recommended for the diagnosis of latent TB infection [1]. A Quantiferon Gold test is considered positive if the result is ≥0.35 IU·mL−1 [2]. However, longitudinal studies have shown that a significant number of test reversions and conversions occur if results just above or below this threshold are repeated [3, 4]. This variation may be due to random chance or other factors such as test-related errors, differences in absolute lymphocyte numbers and within-subject variability of the interferon-γ response [5, 6]. The high proportion of conversions and reversions around the 0.35 IU·mL−1 cut-off has led some to suggest that a borderline or equivocal range should be used [7], as this avoids treatment of individuals who do not have a 'stable' positive result, as well as failure to treat those just below the 0.35 threshold who would convert to a positive result if the test were repeated [6]. Borderline and equivocal results for the Quantiferon Gold test are common and repeated borderline tests often change <http://ow.ly/PDDZ30fqJ1c> We would like to thank Ronnie Chee, Mark Davis and Annabelle Mai for assistance with the recording, distribution and supervision of results.
Comment on l’Ami <i>et al</i> titled ’Successful reduction of overexposure in patients with rheumatoid arthritis with high serum adalimumab concentrations: an open-label, non-inferiority, randomised clinical trial'
Authors: Alfons A den Broeder, Bart J F van den Bemt
Journal: Annals of the Rheumatic Diseases (2017)

We have read the recent paper of l‘Ami et al titled ‘Successful reduction of overexposure in patients with rheumatoid arthritis with high serum adalimumab concentrations: an open-label, non-inferiority, randomised clinical trial’ with interest.1 The topic of dose tapering is an important one and we welcome all research efforts in this field, especially controlled trials. However, the design choices and interpretation of current study have some important limitations that in our opinion merit more attention.

First, l‘Ami et al set out to assess whether interval prolongation with 50% of adalimumab injections in patients with rheumatoid arthritis doing well is feasible when patients have a trough level …
Activation and Inhibition of Sodium-Hydrogen Exchanger Is a Mechanism That Links the Pathophysiology and Treatment of Diabetes Mellitus With That of Heart Failure
Authors: Milton Packer
Journal: Circulation (2017)

The mechanisms underlying the progression of diabetes mellitus and heart failure are closely intertwined, such that worsening of one condition is frequently accompanied by worsening of the other; the degree of clinical acceleration is marked when the 2 coexist. Activation of the sodium-hydrogen exchanger in the heart and vasculature (NHE1 isoform) and the kidneys (NHE3 isoform) may serve as a common mechanism that links both disorders and may underlie their interplay. Insulin insensitivity and adipokine abnormalities (the hallmarks of type 2 diabetes mellitus) are characteristic features of heart failure; conversely, neurohormonal systems activated in heart failure (norepinephrine, angiotensin II, aldosterone, and neprilysin) impair insulin sensitivity and contribute to microvascular disease in diabetes mellitus. Each of these neurohormonal derangements may act through increased activity of both NHE1 and NHE3. Drugs used to treat diabetes mellitus may favorably affect the pathophysiological mechanisms of heart failure by inhibiting either or both NHE isoforms, and drugs used to treat heart failure may have beneficial effects on glucose tolerance and the complications of diabetes mellitus by interfering with the actions of NHE1 and NHE3. The efficacy of NHE inhibitors on the risk of cardiovascular events may be enhanced when heart failure and glucose intolerance coexist and may be attenuated when drugs with NHE inhibitory actions are given concomitantly. Therefore, the sodium-hydrogen exchanger may play a central role in the interplay of diabetes mellitus and heart failure, contribute to the physiological and clinical progression of both diseases, and explain certain drug-drug and drug-disease interactions that have been reported in large-scale randomized clinical trials.
TCT-566 Stent fracture is associated with a higher mortality in patients with type-2 diabetes treated by implantation of a second-generation drug-eluting stent
Authors: Zhen Ge, Jing Kan, Junjie Zhang, Suiji Li, Nailiang Tian, Fei Ye, Xue-Song Qian, Song Yang, Tanveer Rab, Shao-Liang Chen
Journal: Journal of the American College of Cardiology (2017)
Abstract 362: Deletion of Gata4 and Gata6 in the c-Kit Lineage Augments Cellular Fusion in vivo
Authors: Bryan D Maliken, Onur Kanisicak, Jeffery D Molkentin
Journal: Circulation Research (2016)

Cell therapy for treatment of ischemic heart disease has been under rigorous evaluation in recent years. Heart-derived c-Kit cells showed promising results in clinical trials with scar reduction and improved ejection fraction following coronary infusion. We previously developed a c-Kit lineage tracing model showing that these cells very rarely convert into de novo cardiomyocytes. To potentially reduce this rate to zero, and unequivocally evaluate cellular fusion processes in vivo, we deleted the cardiogenic transcription factors Gata4 and Gata6 in c-Kit cells using a Cre-loxP approach (Kit-Gata4/6 KO). We used the tamoxifen inducible Kit-MerCreMer allele crossed into Gata4/6 homozygous LoxP targeted background and the Rosa26-eGFP reporter, which were given tamoxifen at weaning to delete Gata4 and Gata6 in all c-Kit expressing cells and show them and their progeny as eGFP positive. Unexpectedly, we observed a greater than 10-fold increase in Kit lineage-traced cardiomyocytes in some Kit-Gata4/6 KO mice compared to Kit only controls with up to 4 months of treatment. Exploration of other tissues revealed a dramatic increase in presumed Kit-lineage traced skeletal muscle fibers in Kit-Gata4/6 KO mice as well. However, investigation of this effect suggested that this increase in presumed Kit-lineage traced cardiomyocytes and skeletal muscle fibers was due to an alteration in the immune cell compartment of these mice that generated greater rates of fusion. Indeed, analysis of Kit-derived hematopoietic lineages present in the heart showed a 6-fold increase in leukocyte infiltration (CD45 + ) and a 60-fold increase in dendritic cells (CD11c + ) from Kit-Gata4/6 KO mice. Kit-eGFP + bone marrow was also transplanted into mice expressing a membrane tomato reporter. Kit-Gata4/6 KO bone marrow showed a 3-fold increase in Kit-eGFP cells, although all these myocytes had the membrane tomato tag indicting that these events were all due to fusion. Hence, alterations in c-Kit cell activity likely impacts the activity of the immune system and the fusigenic activity of derived cells.