tbuckley/cabot-search huggingface dataset:
SAT0728-HPR Evaluation of the effectiveness of an educational program in patients with osteoarthritis of the knees
Authors: L.Y. Miura, A. Jones, C. Brumini, J. Natour
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Osteoarthritis (OA) is the most common chronic joint disease, affecting about 50% of the population aged 65 or over, its incidence tends to increase according to the age. Educational intervention is considered an important part of treatments for chronic diseases. However, in the literature, for OA there is still no standard of educational program to be followed. <h3>Objectives</h3> To evaluate the effectiveness of the educational intervention in patients with knee osteoarthritis regarding to pain, function, anxiety and quality of life <h3>Methods</h3> Sixty patients with knee OA, both genders and age between 40 to 80 years, were included. The patients were randomised into 2 groups: Experimental Group (EG) received an educational intervention, composed of 5 consecutive sessions held once a week, with a duration of 60 min each session. At the end of the last class, a booklet was given to each patient with all the content of the classes. In addition to the educational program, this EG also received a TENS (Transcutaneous Nerve Electrical Stimulation) treatment performed twice a week for 5 weeks for 40 min each session. Control group (CG) received the same TENS treatment as EG group. The evaluations were performed at baseline, 4 and 12 weeks after baseline with the following instruments: numerical pain scale (NPS) for pain; WOMAC questionnaire and 6 min walk test for function; IDATE questionnaire for anxiety and SF-36 questionnaire for quality of life. <h3>Results</h3> Regarding the variables pain, function, anxiety and quality of life, no statistically significant difference was found between groups over time. (table 1) The intragroup comparisons show na improvement in both groups between T0 and T4 and T0 and T12for: pain; function total and pain score of WOMAC and domains physical role functioning and social role functioning of SF-36 (table 1) <h3>Conclusions</h3> This educational intervention was not effective in improving pain, function, anxiety and quality of life in patients with osteoarthritis of the knees. <h3>References</h3> [1] Barlow J, Turner A, Swaby L, et al. An 8-yr follow-up of Arthritis Self-Management Programme participants. Rheumatology2009;48:128–33. [2] Fernandes L, Hagen KB, Bijlsma JWJ, et al. EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis. Ann Rheum DisPublished Online First. Published on April 17, 2013as 10.1136/annrheumdis-2012–202745 <h3>Disclosure of Interest</h3> None declared
Google tech company must spell out how it will make money from the NHS
Authors: Nigel Hawkes
Journal: BMJ (2018)

DeepMind Health, the health tech company owned by Google, should define how it intends to make money if it is to avoid suspicion of being a means of milking NHS data, its own review panel has said in a new report.1

The company ran into criticism when it signed a deal with the Royal Free Hospital in London in 2016 to use patient data to test a mobile app called Streams with the aim of improving treatment of acute kidney injury.2 The Information Commissioner ruled last July that the Royal Free had breached data protection law in supplying the data.3

Streams has since been rolled out to Imperial College and to hospital trusts in Yeovil and Taunton, yet DeepMind Health has yet to make a penny out of it. …
Abstract 11451: Preoperative Syntax Score and Graft Patency After Off-pump Coronary Bypass Surgery
Authors: Takeshi Kinoshita, Tohru Asai, Tomoaki Suzuki
Journal: Circulation (2012)

Introduction: We retrospectively examined the association between preoperative SYNTAX score and graft patency after off-pump CABG. Methods and Results: Of 912 consecutive patients undergoing isolat...
SAT0019 Tnf-Α regulates plasmacytoid dendritic cells by suppressing ifn-Α production and enhancing th1 and th17 cell differentiation
Authors: A. Psarras, A. Antanaviciute, I. Carr, M. Wittmann, P. Emery, G. Tsokos, E.M. Vital
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Human plasmacytoid dendritic cells (pDCs) play a vital role in modulating immune responses. pDCs can produce massive amounts of type I IFNs in response to nucleic acids via toll-like receptors (TLRs) and they are known to possess weak antigen-presenting properties inducing CD4<sup>+</sup> T cell activation. Previous data showed a cross-regulation between TNF-α and IFN-α but the effect of TNF-α on pDCs remains unclear. <h3>Objectives</h3> To investigate how TNF-α regulates the immune function of human pDCs. <h3>Methods</h3> Fresh PBMCs were treated with TNF-α, TLR7 and TLR9 synthetic agonists. pDCs were immunophenotyped using flow cytometry. RNA from sorted pDCs was extracted and sequenced using Smart-seq2 for sensitive full-length transcriptome profiling. For pDC/T cell co-culture, fresh or TNF-α-treated pDCs were cultured with na&amp;x00EE;ve CD4<sup>+</sup> T cells for 5 days. The production of cytokines was measured by intracellular staining and ELISA. <h3>Results</h3> Upon stimulation with TLR7 and TLR9 agonists, there were three main pDC populations: non-producers, TNF-α-producers, TNF-α/IFN-α-producers. Exogenous TNF-α significantly reduced the production of both IFN-α and TNF-α in TLR9-stimulated pDCs but only IFN-α in TLR7-stimulated pDCs. Neutralisation of autologous TNF-α with anti-TNF antibody partially sustained IFN-α secretion by TLR9-stimulated pDCs after 24 hours. Exogenous TNF-α significantly promoted pDC maturation by upregulation of costimulatory molecules and chemokine receptors such as CD80, CD86, HLA-DR, and CCR7. RNAseq data analysis suggested that TNF-α inhibits IFN-α/TNF-α production by interfering with the NFκB pathway, promotes antigen processing and presentation pathways as well as T cell activation and differentiation. Indeed, TNF-α-treated pDCs induced <i>in vitro</i> higher CD4<sup>+</sup> T cell proliferation and favoured Th1/Th17 polarisation. <h3>Conclusions</h3> Although pDCs possess weak antigen-presenting properties, TNF-α can enhance pDC maturation by switching their main role as IFN-α-producing cells to a more conventional DC phenotype. The functional status of pDCs might be strongly influenced by overall inflammatory environment and TNF-α might regulate IFN-α-mediated aspects of a range of autoimmune and inflammatory diseases. <h3>Disclosure of Interest</h3> None declared
THU0372 Ultrasonographic scoring of the major salivary glands: is there a relationship with disease activity and functional status of the glands ?
Authors: N. Inanc, Y. Yalcinkaya, G. Mumcu, Z. Erturk, A.U. Unal, P. Atagunduz, H. Direskeneli
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Ultrasonography (USG) of major salivary glands (SG-USG)is a non-invasive tool that has been used to evaluate salivary glands in primary and secondary Sjogren's syndrome (SjS). <h3>Objectives</h3> We aimed to investigate relation between the ultrasonographic scoring of major salivary glands and systemic disease activity or salivary secretion in patients with primary SjS. <h3>Methods</h3> Seventy-five SjS patients (F/M:73/2) with the mean age of 52±12 and duration of follow-up period of 58±54 months fulfilling ACR-EULAR classification criteria (2002) were included. Disease activity indexes (Sjögren's Syndrome Patients Reported Index (ESSPRI), Visual Analogue Scale (VAS), EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI)] were recorded. Simultaneously, sialometric evaluation of the salivary glands was performed. Major salivary glands (bilateral parotis and submandibular glands) were scored according to two different scoring systems [Hocevar A.(0–48) and Milic VD. (0–12)] and elastography was recorded as well. <h3>Results</h3> Demographics, clinical characteristics, disease activity indexes and SG-USG scores were summarised in table 1 and table 2. Forty-one (55%) and 45 (60%) patients had the cut-off values of ≥17 (Hocevar) and ≥6 (Milic USG). The patients with the scores of ≥17 (Hocevar) were found to have higher scores of ESSPRI-total (16±6 vs 13±7, p=0,045) and lower sialometry (4,6±4,7 vs 8,4±4,6 ml, p=0,002). Scores of Hocevar and Milic-USG were negatively correlated with sialometry (r=-,430, p=0001 and r=-,430, p=0,001). Hocevar, Milic and elastography-USG scores were shown to be higher in patients with sialometry of ≤1,5 ml (n=7)(28±3 vs 17±10, p=0,010, 8±1 vs 5±3, p=0006 and 9±1 vs 5±2, p=0,028) and anti-Ro positivity(n=24) (24±10 vs 13±8 7±3 vs 4±2, p&lt;0001 and 7±2 vs 3±2, p=0,003). The patients with severe parotid involvement (inhomogeneity/hypoechogenic areals≥2) had more frequent anti-Ro and anti-La positivity (80 vs 42%, p=0004 and 48 vs 17%, p=0,011) <h3>Conclusions</h3> Hocevar scoring system of major salivary glands was found to be related to patient reported activity in SjS. USG scores were associated with reduced saliva secretion and anti-Ro positivity. Severe parotid involvement was shown to be related to anti-RO and La positivity. Evaluation of SG-USG including different scoring systems and elastography might reflect function of the salivary glands. <h3>Disclosure of Interest</h3> None declared
A novel biliary cannulation method for difficult cannulation cases using a unique, uneven, double-lumen cannula (Uneven method)
Authors: Mamoru Takenaka, Yoshifumi Arisaka, Arata Sakai, Takashi Kobayashi, Hideyuki Shiomi, Atshuhiro Masuda, Masatoshi Kudo
Journal: Endoscopy (2018)

The utility of pancreatic duct guidewire (P-GW) placement techniques, including the contrast-medium method and the contrast-free wire-guided cannulation method (i. e. the "double-guidewire method" [D-GW]), has been reported for selective biliary cannulation in patients in whom performing cannulation of the bile duct is difficult [1] [2] [3] [4] [5]. However, P-GW placement often disturbs the approach to the bile orifice. Moreover, it is sometimes difficult to insert the catheter or guidewire in the direction of the bile duct, which delays biliary cannulation.
Marked Prognostic Impact of Minimal Lymphatic Tumor Spread in Prostate Cancer
Authors: Waldemar Wilczak, Corinna Wittmer, Till Clauditz, Sarah Minner, Stefan Steurer, Franziska Büscheck, Till Krech, Maximilian Lennartz, Luisa Harms, Diane Leleu, Marc Ahrens, Sebastian Ingwerth, Christian T. Günther, Christina Koop, Ronald Simon, Frank Jacobsen, Maria C. Tsourlakis, Viktoria Chirico, Doris Höflmayer, Eik Vettorazzi, Alexander Haese, Thomas Steuber, Georg Salomon, Uwe Michl, Lars Budäus, Derya Tilki, Imke Thederan, Christoph Fraune, Cosima Göbel, Marie-Christine Henrich, Manuela Juhnke, Katharina Möller, Ahmed Abdullah Bawahab, Ria Uhlig, Meike Adam, Sören Weidemann, Burkhard Beyer, Hartwig Huland, Markus Graefen, Guido Sauter, Thorsten Schlomm
Journal: European Urology (2018)
AB0558 Are regulatory t cell levels different in active and inactive sle patients?
Authors: H. Üsküdar Teke, D. Üsküdar Cansu, C. Bal, C. Korkmaz
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The subgroups of T helper cells and regulatory T cells (T-reg) are involved in the pathogenesis of systemic lupus erythematosus (SLE). T-reg cells suppress immune response to autoantigens and prevent autoimmune diseases (AID). Although there are studies suggesting that Treg cells are reduced during the active period of SLE, there are also studies claiming reversal. <h3>Objectives</h3> To determine whether there is a difference between T-reg and Th-17 cell levels in active and inactive SLE patients and to demonstrate the effects of these cells on disease course. <h3>Methods</h3> 21 SLE patients without active infection were included. Erythrocyte sedimentation rate, CRP, C3, C4, anti-ds-DNA levels, SLEDAI values were recorded in terms of organ and system involvement, hemogram results, disease activation. SLEDAI ≥6 were considered active disease. Concurrent peripheral blood Th17 and T-reg levels were studied. 15 healthy control subjects were included in the study. <h3>Results</h3> 19 of the patients were women, the mean age was 37.3±12.9 years and mean duration of the disease was 7.9±1.29 years. Hematologic involvement was present in 15 (71.4%) of the patients, renal involvement in 17 (81%) and joint involvement in 7 (42.9%). Both Treg cells and CD4 +IL17+cell levels were significantly higher in SLE group than HC group in terms of CD4 +CD25+, CD4 +FOXP3+T reg, CD4 +CD25+FOXP3+T reg (p=0.011, p=0.001, p=0.001 and p=0.040, respectively). There was no significant difference between active (n=12) and inactive (n=9) SLE patients in terms of Th17 and T-reg levels. However, in the inactive period, the levels of CD4 +FOXP3+T reg and CD4 +CD25+FOXP3+Treg cells tended to increase compared to the active period. <h3>Conclusions</h3> This study showed the tendency of increasing in Treg cells in the inactive period. This may be related to the modification of immunosuppressive drugs. It may be more appropriate to perform similar studies before and after treatment. <h3>Disclosure of Interest</h3> None declared
Metabolic syndrome and risk of incident psoriasis: prospective data from the HUNT Study, Norway
Authors: I. Snekvik, T.I.L. Nilsen, P.R. Romundstad, M. Saunes
Journal: British Journal of Dermatology (2018)

Metabolic syndrome has been associated with psoriasis in cross-sectional studies, but data from prospective studies are sparse.To examine prospectively whether metabolic syndrome and its components are associated with the risk of incident psoriasis in a large population-based study using objective measurements of cardiovascular disease risk factors.We used data from two consecutive surveys of the HUNT Study, Norway (HUNT2, 1995-1997, and HUNT3, 2006-2008). In total 34 996 women and men aged ≥ 20 years without psoriasis in HUNT2 were followed up in HUNT3, and 374 incident cases of psoriasis were identified. We used Cox regression to estimate the adjusted relative risk (RR) of incident psoriasis with its 95% confidence interval (CI).Metabolic syndrome was associated with an RR for psoriasis of 1·66 (95% CI 1·30-2·14). To explore the influence of adiposity on this association, we first excluded waist circumference from the definition of metabolic syndrome (adjusted RR 1·54, 95% CI 1·14-2·07) and then adjusted for body mass index (RR 1·33, 95% CI 0·97-1·81). Analyses of the separate components of metabolic syndrome showed positive associations with risk of psoriasis for waist circumference, triglycerides and high-density lipoprotein (HDL) cholesterol, but not for blood pressure or blood glucose. There was also an increased risk of psoriasis for high total cholesterol. The increased risk associated with high triglycerides, HDL cholesterol and total cholesterol was attenuated after adjusting for body mass index.In this large prospective study from a general population, we found that metabolic syndrome was associated with increased risk of incident psoriasis, and our results suggest that this positive association could, at least partly, be attributed to adiposity.
Patient Education on Patellofemoral Pain—Reply
Authors: Jill Jin, Emily Jones
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Application of BioFire FilmArray Blood Culture Identification panel for rapid identification of the causative agents of ventilator-associated pneumonia
Authors: M.R. Pulido, P. Moreno-Martínez, V. González-Galán, F. Fernández Cuenca, Á. Pascual, J. Garnacho-Montero, M. Antonelli, G. Dimopoulos, J.A. Lepe, M.J. McConnell, J.M. Cisneros, P. Ramírez Gallmore, J. Bonastre, J.C. Montejo González, R.O. Díaz-Miguel, A.E. García, R.Z. Crespo, R.S. Camerino, M.H. Gutiérrez, L. Alvarez-Rocha, M. Sanchez Garcia, J.M. Allegue Gallego, Á. Castellanos Ortega, M.V. de la Torre Prados, R.F. Roca, P.V. Cortés, A. Armaganidis, None Serafim, D. Georgopoulos, L. Pneumatikos, G. Nakos, G. Baltopoulos, A. Koutsoukou, E. Zakynthinos, None Militsa-Bitsani, A. Komnos, M. Pennisi, G. De Pascale, V. Di Gravio, M. Rocco, R. De Blasi, A. De Gasperi, V.M. Ranieri- Francesco de Rosa, E. De Robertis-Rosalba, None Guarracino
Journal: Clinical Microbiology and Infection (2018)
MELO-D: Antiproliferative effects of melatonin and vitamin D in breast cancer.
Authors: Punam Rana
Journal: Journal of Clinical Oncology (2014)

TPS1616 Background: Vitamin D and melatonin have been associated with anti-cancer activity in epidemiological and experimental studies. However, evidence from controlled trials on their efficacy in cancer prevention is inconsistent, in part related to lack of knowledge on the mechanism of preventive activity. The MELO-D study is the first to use an innovative pre-operative chemoprevention approach to examine the potential anticancer role of vitamin D and melatonin. We hypothesize that vitamin D and separately, melatonin, decreases the proliferative activity in a breast cancer tumor, as measured by Ki67. Methods: Using a 2x2 factorial design, 144 women diagnosed with invasive breast cancer are randomized to receive Vitamin D3 (2000 IU daily) or placebo, and to melatonin (20 mg/day) or placebo. The duration of study medication is 3-4 weeks while the subjects wait for definitive breast cancer surgery. The primary outcome is difference in Ki67 between the initial core biopsy and final surgical specimen. The mean difference in Ki67 from baseline to definitive surgery will be compared between groups. The effect of Vitamin D and melatonin will also be examined in relation to other factors including serum vitamin D levels, genetic factors (e.g. VDR polymorphism), and tissue factors (e.g. p53 status). Patients are currently being recruited from the Juravinski Cancer Centre (JCC) and St. Joseph’s Healthcare Hamilton. Clinical trial information: NCT01965522.
Abstract 14292: A New MAZE Procedure With Intensive Pulmonary Veins Isolation
Authors: kazuo yamanaka, Jin Ikarashi, Takasyoshi Kusuhara, Kenta Ann, Daisuke Nakatsuka, Keiichi Hirose, Atsushi Iwakura, Masatoshi Fujita
Journal: Circulation (2010)

Objective:  Combined treatment of pulmonary vein isolation (PVI) and ganglionated plexus (GP) ablation has been developed as a treatment of atrial fibrillation (AF). We investigated the effect of new MAZE procedure with intensive PVI guided by GP mapping on postoperative maintenance of sinus rhythm in patients with chronic AF, and compared with that in patients undergoing the MAZE procedure with conventional PVI.   Methods:  We studied 43 patients [conventional PVI group: 68.8±5.7 years] and 24 patients [intensive PVI group: 66.9±7.4 (SD) years] who underwent the MAZE procedure for chronic AF. The MAZE procedure was conducted by the endocardial application of bipolar radiofrequency (RF) ablation. Lesion sets in the left atrium were similar in the 2 groups. In the conventional PVI group, PVI was applied 3 times for the entrance of 4 pulmonary veins. In the intensive PVI group, PVI was further repeated several times for the bilateral GP regions identified by a rapid atrial pacing test.   Results:  The MAZE procedure was successfully completed in all 67 patients without complications. The duration of chronic AF, the prevalence of concomitant mitral valvular disease and the postoperative follow-up period were comparable between the 2 groups. At 20.8±9.0 months after the surgery, sinus rhythm was maintained in 25 (53%) of 43 patients of the conventional PVI group. In contrast, it was maintained in 20 (83%) of 24 patients of the intensive PVI group (p   Conclusions:  New MAZE procedure with intensive PVI guided by GP mapping largely contributes to the long-term maintenance of sinus rhythm.
Breast MRI in elderly patients with breast cancer: Does breast density matter?
Authors: Jennifer Casher, Michelle Stempel, Anne Eaton, Elizabeth Ann Morris, Mary Gemignani
Journal: Journal of Clinical Oncology (2012)

e11531 Background: MRI of the breast (BR) is useful in patients (pts) with dense BR in extent of disease evaluation (EOD) and high risk screening. The purpose of this study was to investigate whether MRI breast cancer (BC) detection was associated with BR density in elderly pts. Methods: Retrospective review included pts age &gt;69 diagnosed with BC at our institution between 2/2001 and 12/2005 and their concurrent BR MRIs as well as clinical and pathologic factors. BR density was defined as mild (M) if BR were fatty/mildly dense, and dense (D) if BR were moderately/extremely dense. MRI data was coded for the number of additional sites beyond the known cancer site. Results: MRI occurred in 113 BR in 59 pts; 5 pts had unilateral MRI. 3 pts had bilateral BC. The mean age was 74 (range 69-84). Median tumor size was 1.2 cm (range 0.06-2.6, n=54). 27 pts (46%) had M density and 32 (54%) had D density. In 51/62 (82%) the index lesion was mammographically detected, and in 11 (17%) it was mammographically occult. The majority of BR MRIs 36/62 (58%) identified no additional sites. Biopsy was performed for 18/29 (62%) of the additional sites and 6 cancers were found (PPV of 33%). MRI detected an additional site of BC in 6/62 (9.7%) diseased BR and a new BC in 4/51 (7.8%) screened BR. Pts with D density had more additional MRI sites 18/33 (54.6%) as compared with M density 8/29 (27.6%) p = 0.04. However, D density was not associated with increase in BC detection; 4/33 (12%) D vs 2/29 (7%) M density, p =0.67. BR conserving surgery was performed in 46 pts and mastectomy in 16. We did not find a correlation between additional sites on MRI and final mastectomy, p=0.56. Conclusions: In our study the majority of pts had mammographically evident BC at the time of diagnosis and unifocal BC on MRI. We found that although 54% of our pts had dense BR, the additional detection of BC in the BR by MRI was the same as in pts with mild density. However, we found that increased density was associated with an increased detection of additional lesions on MRI. [Table: see text]
NEDD9 targets <i>COL3A1</i> to promote endothelial fibrosis and pulmonary arterial hypertension
Authors: Andriy O. Samokhin, Thomas Stephens, Bradley M. Wertheim, Rui-Sheng Wang, Sara O. Vargas, Lai-Ming Yung, Minwei Cao, Marcel Brown, Elena Arons, Paul B. Dieffenbach, Jason G. Fewell, Majed Matar, Frederick P. Bowman, Kathleen J. Haley, George A. Alba, Stefano M. Marino, Rahul Kumar, Ivan O. Rosas, Aaron B. Waxman, William M. Oldham, Dinesh Khanna, Brian B. Graham, Sachiko Seo, Vadim N. Gladyshev, Paul B. Yu, Laura E. Fredenburgh, Joseph Loscalzo, Jane A. Leopold, Bradley A. Maron
Journal: Science Translational Medicine (2018)

TGF-β–independent oxidative modification of NEDD9 at Cys 18 promotes vascular fibrosis and the pathobiology of pulmonary arterial hypertension.
Reversible RNA Modification<i>N</i>1-Methyladenosine (m1A) in mRNA and tRNA
Authors: Chi Zhang, Guifang Jia
Journal: Genomics Proteomics & Bioinformatics (2018)

More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins. Apart from N