tbuckley/cabot-search huggingface dataset:
Molecular and Histopathological Characterization of the Tumor Immune Microenvironment in Advanced Stage of Malignant Pleural Mesothelioma
Authors: Namrata S. Patil, Luisella Righi, Hartmut Koeppen, Wei Zou, Stefania Izzo, Federica Grosso, Roberta Libener, Marco Loiacono, Valentina Monica, Consuelo Buttigliero, Silvia Novello, Priti S. Hegde, Mauro Papotti, Marcin Kowanetz, Giorgio V. Scagliotti
Journal: Journal of Thoracic Oncology (2017)
Effectiveness of Injectable Extended-Release Naltrexone vs Daily Buprenorphine-Naloxone for Opioid Dependence
Authors: Lars Tanum, Kristin Klemmetsby Solli, Zill-e-Huma Latif, Jurate Šaltyte Benth, Arild Opheim, Kamni Sharma-Haase, Peter Krajci, Nikolaj Kunøe
Journal: JAMA Psychiatry (2017)

To date, extended-release naltrexone hydrochloride has not previously been compared directly with opioid medication treatment (OMT), currently the most commonly prescribed treatment for opioid dependence.
Calendarios vacunal en los paises de la Union Europea
Authors: N Guérin, C Roure
Journal: Eurosurveillance (1995)

La Oficina Regional de la OMS en Europa organiza reuniones sobre los programasde inmunizacion para expertos nacionales de todos los paises de laUnion Europea. Dicha Oficina recibe regularmente datos sobre laincidencia de las enfermedades y la cobertura de inmunizacion. Se hananalizado los calendarios de inmunizacion a partir de las informacionesde los planos nacionales desarrollados en cada pais. Es dificil mantener estasinformaciones actualizadas pues la politica de inmunizacion estaa menudo adaptada a una respuesta por cambios epidemicos o por eldesarrollo de nuevas vacunas. Ademas, la politica puede variar entre lasdiferentes regiones dentro de un mismo pais.
Image Gallery: Unusual images of monilethrix: the eyebrows and the biopsy
Authors: A. Anzai, A. Munck, C. Costa Fechine, C. Gavioli, N. Valente, R. Romiti
Journal: British Journal of Dermatology (2017)

Funding sources: no external funding. Conflicts of interest: none to declare. Dear Editor, A 30‐year‐old woman presented with sparse scalp hair since birth with inability to grow and reduction of corporal hairs and eyebrows. She denied consanguineous parents but reported an aunt with similar features. She had her eyebrows tattooed and used hair extensions to mask the hypotrichosis. Scalp examination revealed nonaffected hairs alongside short and broken hairs, and keratotic pigmented papules mainly involving the occiput. Nails and teeth were normal. Trichoscopy of the scalp and eyebrows (a, × 20; b, × 70) and optical microscopy (c, × 80) revealed regular constrictions of the shaft, giving a characteristic beaded appearance.1 The scalp biopsy showed follicles with narrowing hair shafts (d).
Doctors' communication of trust, care, and respect
Authors: Emma Burkitt Wright, Christopher Holcombe, Peter Salmon
Journal: BMJ (2004)

In this article, the authors propose a variance-dependent explanation for the contradiction between skewness preference and low expected return concerning lottery stocks. They emphasize an overlooked aspect of skewness as a risk measure: the return uncertainty of extreme events. They show that, during periods of low market volatility, investors dislike large-skewness securities owing to a fear of uncertain results. Thus, one observes a positive relation between skewness and expected return because the security is currently undervalued. Conversely, negative associations occur in high-volatility environments. This conditional skewness–return nexus is demonstrated to possess return predictability and can help in adjusting portfolios with profitable buying and selling decisions. <b>Key Findings</b> ▪ The authors propose variance-dependent skewness to reconcile the skewness preference for lottery stocks with their actual low expected returns. ▪ They emphasize skewness as a risk measure of the return uncertainty of extreme events. ▪ The authors construct portfolios based on the return predictability of skewness conditional on volatility and show that these portfolios remain profitable after considering transaction costs and restrictions on short sales.
Monitoraggio dell'influenza nei paesi membri del network europeo EISS da ottobre 2000 a aprile 2001
Authors: K Mantey, A Mosnier, W J Paget
Journal: Eurosurveillance (2001)

Nei paesi partecipanti allo European Influenza Surveillance Scheme (EISS), l'inverno 2000-2001 e stato colpito principalmente dalla diffusione dei virus dell'influenza di tipo A(H1N1). L'influenza B, che rappresenta globalmente una minoranza di casi, si e diffusa piu avanti nella stagione ed e stata predominante in Gran Bretagna, Irlanda e Portogallo. L'influenza e stata attiva al suo massimo durante il periodo gennaio e febbraio/marzo 2001 con piccolo intervallo di tempo tra paesi (massimo quattro settimane). Nel complesso, i tassi di morbosita riportati sono stati molto piu bassi che nella precedente stagione, il che mostra un livello moderato di attivita influenzale.
A retrospective analysis of gemcitabine and nab-paclitaxel for the treatment of metastatic cholangiocarcinoma.
Authors: Arjun Mittra, Aixa Elena Soyano, Shu Ting Kung, Mitesh J. Borad, Steven R. Alberts, Kabir Mody
Journal: Journal of Clinical Oncology (2017)

e15616 Background: Cholangiocarcinoma (CCA) is a progressively fatal disease with an annual incidence of 1-2 cases per 100,000 people in the USA. Complete surgical resection is the only curative option for CCA. However, the majority of patients (pts) have advanced disease at diagnosis, and those undergoing resection often develop local or distant recurrence. Gemcitabine and Cisplatin remains the only standard chemotherapeutic regimen for advanced CCA. Alternative and improved therapies are critically needed. Gemcitabine/nab-Paclitaxel (GA) is a regimen that has become standard therapy in advanced pancreatic cancer (PDAC). Given the morphologic and histologic similarities between PDAC and CCA, this regimen has been used in advanced CCA, but no data exists regarding its efficacy in this disease. The goal of our study is to evaluate the Mayo Clinic experience with GA for the treatment of metastatic CCA. Methods: We retrospectively analyzed records from adult pts at Mayo Clinic with metastatic cholangiocarcinoma who received at least 2 cycles of GA. Our aims were to assess the progression-free survival (PFS), overall survival (OS) and disease response. Results: We analyzed 9 pts, 3 male and 6 female. The median age at diagnosis was 50 years (range 41-64). Six pts had metastatic disease at diagnosis while 3 underwent surgery with subsequent distant disease recurrence. Pts received a median of 2 lines (range 0-5) of systemic therapy prior to receiving GA, and a median of 2 cycles (range 2-15) of GA. At the time of our analysis, 4 of the 9 pts (44%) had died. The median OS from initiation of GA was 7.3 months (95% CI 1.7- 12.9) and median PFS from initiation of GA was 4.7 months (95% CI 0.48-8.9). The best overall responses using RECIST criteria were: partial response in 1 (11%), stable disease in 5 (55%) and disease progression in 3 (33%) pts. One pt remained on therapy 14.9 months after initiating GA. Conclusions: In our study, the combination of gemcitabine and nab-paclitaxel has demonstrated similar OS and PFS as other systemic therapies. To the best of our knowledge, this is the first report of this regimen in CCA. Ongoing, prospective trials are currently evaluating this regimen in advanced CCA.
TCT-728 Polymer-free sirolimus eluting stents in a large scale all comers population
Authors: Markus Florian Krackhardt, Matt Waliszewski, Viktor Kocka, Andreas Utech, Meik Lustermann, Martin Hudec, Martin Studencan, Jiangtao Yu, Markus Schwefer, Myung Ho Jeong, Taehoon Ahn, Wan Azman Wan Ahmad, Michael Boxberger, Matthias Leschke
Journal: Journal of the American College of Cardiology (2017)
Inflammageing and metaflammation: The yin and yang of type 2 diabetes
Authors: Francesco Prattichizzo, Valeria De Nigris, Rosangela Spiga, Elettra Mancuso, Lucia La Sala, Roberto Antonicelli, Roberto Testa, Antonio Domenico Procopio, Fabiola Olivieri, Antonio Ceriello
Journal: Ageing Research Reviews (2017)
TCT-384 The Myocardial Contraction Fraction Predicts Adverse Events after Aortic Valve Replacement: An Analysis of 3,259 Patients from the Pooled PARTNER 2 Database
Authors: Mahesh Madhavan, Matthew Maurer, Bjorn Redfors, Wael Jaber, Philippe Pibarot, Pamela Douglas, Raj Makkar, Vinod Thourani, Howard Herrmann, Nimesh Desai, Michael Mack, Sammy Elmariah, William Fearon, Brian Lindman, Philipp Blanke, Jonathon Leipsic, Yiran Zhang, Thomas McAndrew, Maria Alu, Susheel Kodali, Martin Leon, Rebecca Hahn
Journal: Journal of the American College of Cardiology (2017)
Abstract 12888: Risk of Sudden Cardiac Death and Coronary Heart Disease Mortality in Postmenopausal Women With History of Weight Cycling
Authors: Somwail Rasla, Marina Garas, Mary B Roberts, Molly E Waring, Christine M Albert, Deepika Laddu, Marcia L Stefanick, David K Garas, Charles B Eaton
Journal: Circulation (2016)

Introduction: Elevated midlife body mass index (BMI) is associated with sudden cardiac death (SCD) and coronary heart disease (CHD) mortality. However, it is not known whether weight cycling across adulthood increases risk of SCD and CHD mortality. Hypotheses: Weight cycling will be associated with risk of SCD and CHD mortality. This association will vary by baseline BMI. Methods: Prospective cohort study of 158,063 post-menopausal women from the Women’s Health Initiative (WHI). Self-reported weight history during adulthood was categorized as stable weight, steady gain, maintained weight loss, and weight cycling. SCD was defined as a sudden loss of consciousness within one hour of the onset of symptoms with a documented loss of pulse in a previously stable individual without evidence of non-cardiac cause of the arrest. CHD mortality was determined by physician-adjudicated review of medical record reviews. Cox proportional hazard models estimated age- and multivariate-adjusted hazards ratios (HRs) and 95% confidence intervals (CIs). Results: Over 11.4 years of follow-up (1,798,063 person-years), 2526 CHD deaths occurred and 83 SCDs were adjudicated by strict criterion. Compared to stable weight, weight cycling was associated with greater risk of SCD and CHD mortality among women who were normal weight at WHI enrollment (HR=3.44 95% CI: 1.25-9.45 for SCD; HR=1.66, 95% CI: 1.38-2.01 for CHD mortality). Weight cycling was not associated with SCD or CHD mortality among overweight or obese women (Table). Neither steady weight gain nor weight loss were associated with risk of SCD or CHD mortality (Table). Conclusions: Weight cycling during adulthood in post-menopausal women may increase the risk of SCD as well as CHD mortality. This association appears strongest in normal BMI women.
Brote de infecciones por Salmonella enterica serotipo Manhattan asociadas a productos cárnicos, Francia, 2005-06
Authors: H Noël, M Dominguez, F X Weill, A Brisabois, C Duchazeaubeneix, A Kerouanton, G Delmas, N Pihier, E Couturier
Journal: Eurosurveillance (2006)

Entre agosto de 2005 y marzo 2006, se declararon 69 casos de Salmonella enterica serotipo Manhattan (Salmonella Manhattan) en Francia, de los cuales 51 (el 74%) se localizaban en el sureste del pais. 
En el momento de la alerta (noviembre de 2005), se entrevistaron 13 casos y 33 controles. La probabilidad de haber consumido salchichas de cerdo (OR=5.9, intervalo de confianza IC [1.3; 26.9]) y carne de vaca (OR=9.3, IC [1.3; 68.6]) era mayor en los casos que en los controles. 
Al mismo tiempo, 19 cepas de Salmonella Manhattan aisladas en productos carnicos en el sureste de Francia y notificadas al Afssa (Agence francaise de securite sanitaire des aliments, Agencia francesa de seguridad sanitaria de alimentos) en septiembre y noviembre de 2005, tenian un perfil de electroforesis en campo pulsado indistinguible de los siete aislamientos humanos de Salmonella Manhattan procedentes del brote del sureste de Francia. Las investigaciones veterinarias mostraron que las muestras de carne de cerdo procedian de un mayorista cuyos productos dieron positivo para S. Manhattan en un control alimentario de rutina en agosto 2005. Este mayorista suministraba carne a tiendas del sureste del pais. Ademas, se inspecciono el matadero que abastecia al mayorista, revelando una gran contaminacion por Salmonella spp. y S. Manhattan. La cooperacion entre las agencias nacionales responsables de la salud humana (Institut de veille sanitaire, InVS) y de seguridad alimentaria (Afssa) hizo posible que se identificara la fuente de contaminacion mas probable y que se tomaran medidas adecuadas de control.
Do all roads lead to the Rome? The glycation perspective!
Authors: Saheem Ahmad, Firoz Akhter, Uzma Shahab, Zeeshan Rafi, Mohd. Sajid Khan, Rabia Nabi, Mohd Salman Khan, Khurshid Ahmad, Jalaluddin Mohammad Ashraf, None Moinuddin
Journal: Seminars in Cancer Biology (2017)
TCT-499 Utilization of the Hybrid Approach for Percutaneous Coronary Interventions for Chronic Total Occlusions: Update from a Multicenter Global Registry
Authors: Peter Tajti, Dimitri Karmpaliotis, Khaldoon Alaswad, Farouc Amin Jaffer, Robert Yeh, Mitul Patel, Ehtisham Mahmud, James Choi, Nicholas Burke, Anthony Doing, Catalin Toma, Barry Uretsky, Elizabeth Holper, R. Michael Wyman, William Lombardi, David Kandzari, Nicholas Lembo, Santiago Garcia, Oleg Krestyaninov, Dmitrii Khelimskii, Michail Koutouzis, Ioannis Tsiafoutis, Jeffrey Moses, Ajay Jayant Kirtane, Manish Parikh, Ziad Ali, Raja Hatem, Aris Karatasakis, Judit Karacsonyi, Barbara Anna Danek, Bavana Rangan, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2017)
Abstract 17293: Outcomes and Temporal Trends of Percutaneous Coronary Intervention at Centers With and without On-site Cardiac Surgery in the United States
Authors: Kashish Goel, Tanush Gupta, Dhaval Kolte, Sahil Khera, Gregg C Fonarow, Deepak L Bhatt, Mandeep Singh, Charanjit S Rihal
Journal: Circulation (2016)

Introduction: There are concerns whether percutaneous coronary intervention (PCI) at centers without on-site cardiac surgery (CS) is safe outside of a tightly regulated research environment. Object...
Correlation of Handheld Reflectance Confocal Microscopy With Radial Video Mosaicing for Margin Mapping of Lentigo Maligna and Lentigo Maligna Melanoma
Authors: Oriol Yélamos, Miguel Cordova, Nina Blank, Kivanc Kose, Stephen W. Dusza, Erica Lee, Milind Rajadhyaksha, Kishwer S. Nehal, Anthony M. Rossi
Journal: JAMA Dermatology (2017)

<h3>Importance</h3> The management of lentigo maligna (LM) and LM melanoma (LMM) is challenging because of extensive subclinical spread and its occurrence on cosmetically sensitive areas. Reflectance confocal microscopy (RCM) improves diagnostic accuracy for LM and LMM and can be used to delineate their margins. <h3>Objectives</h3> To evaluate whether handheld RCM with radial video mosaicing (HRCM-RV) offers accurate presurgical assessment of LM and LMM margins. <h3>Design, Setting, and Participants</h3> This prospective study included consecutive patients with biopsy-proven LM and LMM located on the head and neck area who sought consultation for surgical management from March 1, 2016, through March 31, 2017, at the Dermatology Service of the Memorial Sloan Kettering Cancer Center. Thirty-two patients underwent imaging using HRCM-RV, and 22 patients with 23 LM or LMM lesions underwent staged surgery and contributed to the analysis. <h3>Main Outcomes and Measures</h3> Clinical lesion size and area, LM and LMM area based on HRCM-RV findings, surgical defect area estimated by HRCM-RV, and observed surgical defect area. In addition, the margins measured in millimeters estimated for tumor clearance in each quadrant based on HRCM-RV findings were calculated and compared with the surgical margins. <h3>Results</h3> Among the 22 patients (12 men and 10 women; mean [SD] age, 69.0 [8.6] years [range, 46-83 years]) with 23 lesions included in the final analysis, the mean (SD) surgical defect area estimated with HRCM-RV was 6.34 (4.02) cm<sup>2</sup>and the mean (SD) area of surgical excision with clear margins was 7.74 (5.28) cm<sup>2</sup>. Overall, controlling for patient age and previous surgery, surgical margins were a mean of 0.76 mm (95% CI, 0.67-0.84 mm;<i>P</i> &lt; .001) larger than the HRCM-RV estimate. <h3>Conclusions and Relevance</h3> Mapping of LM and LMM with HRCM-RV estimated defects that were similar to but slightly smaller than those found in staged excision. Thus, mapping of LM using HRCM-RV can help spare healthy tissue by reducing the number of biopsies needed in clinically uncertain areas and may be used to plan treatment of LM and LMM and counsel patients appropriately.
TCT-434 Economic benefits of transradial percutaneous coronary intervention; a national analysis from the British Cardiovascular Intervention Society database
Authors: Mamas Mamas, Jon Tosh, William Hulme, James Nolan, George Bungey, Peter Ludman, Mark de Belder, Nick Curzen, Tim Kinnaird, Evan Kontopantelis
Journal: Journal of the American College of Cardiology (2017)
TCT-396 Impact on Public Health of a Network in Acute Myocardial Infarction Care. (IPHENAMIC)
Authors: Guillermo Aldama Lopez, Melisa Santas, Manuel Lopez Perez, Xacobe Flores, Pablo Pinon, Jorge Salgado, Ramon Calvino, Nicolas Vazquez, Jose Manuel Vazquez Rodriguez
Journal: Journal of the American College of Cardiology (2017)
Abstract 20205: Role of Cardiomyocyte Regeneration in Mechanical Unloading Induced Reverse Cardiac Remodeling
Authors: Sean O Bello, Charanjit Singh, Shruti Jayakumar, Prakash Punjabi, Cesare M Terracciano
Journal: Circulation (2016)

Background:  Mechanical unloading with left ventricular assist devices promotes significant myocardial functional improvement in some heart failure patients. The exact mechanism underlying this phenomenon, described as reverse remodeling, remains poorly characterised. Recent reports suggest that the intrinsic regenerative capacity of the heart might contribute to this recovery. We hypothesise that mechanical unloading of the failing heart following myocardial infarction potentiates the proliferation of new cardiomyocytes.   Methods:  Syngeneic male Lewis rats weighing 200 to 300g were studied. Acute myocardial infarction was induced by coronary artery ligation. Two broad groups were created. A permanent ligation group (A) and a reperfusion (coronary circulation restored after 90 minutes) group (B). In each group hearts were either loaded (AL or BL) or unloaded (AU or BU). In the loaded subgroup rats were recovered after coronary ligation. In the unloaded subgroup, the infarcted hearts were explanted after 90 minutes and transplanted into the abdomen of healthy recipients via heterotopic abdominal heart transplantation. The recipient’s heart acted as control. Hearts were explanted on day 7 for immunohistochemistry.   Results:  Twelve rats were studied. There was a significant reduction (24%) in ventricular weight in the unloaded compared to the loaded subgroup (p = 0.026). Coronary reperfusion confers increased proliferative capacity (fig) and this is augmented by mechanical unloading (AL vs BL p = 0.0430, AU vs BU p = 0.0061). There was a 14% increase in cardiomyocyte regeneration with mechanical unloading and proliferating myocytes aggregated mostly around the infarct borderzone.   Conclusion:  In line with published reports, this data shows that adult cardiomyocytes possess an intrinsic regenerative capacity that is stimulated after myocardial injury. Mechanical unloading in addition to coronary reperfusion might augment this regenerative capacity.
Stable High-Sensitivity Cardiac Troponin T Levels and Outcomes in Patients With Chest Pain
Authors: Andreas Roos, Nadia Bandstein, Magnus Lundbäck, Ola Hammarsten, Rickard Ljung, Martin J. Holzmann
Journal: Journal of the American College of Cardiology (2017)

There is a paucity of data on the association between high-sensitivity cardiac troponin (hs-cTn) levels and outcomes in patients with chest pain but no myocardial infarction (MI), or any other condition that may lead to acutely elevated troponin levels. The authors hypothesized that any detectable high-sensitivity cardiac troponin T (hs-cTnT) level is associated with adverse outcomes. All patients (N = 22,589) >25 years of age with chest pain and hs-cTnT analyzed concurrently in the emergency department of Karolinska University Hospital, Stockholm, Sweden from 2011 to 2014 were eligible for inclusion. After excluding all patients with acute conditions that may have affected hs-cTnT, or MI associated with the visit, or insufficient information to determine whether troponin levels were stable, Cox regression was used to estimate risks for all-cause, cardiovascular, and noncardiovascular mortality, MI, and heart failure at different levels of troponins. A total of 19,460 patients with a mean age of 54 ± 17 years were included. During a mean follow-up of 3.3 ± 1.2 years, 1,349 (6.9%) patients died. Adjusted hazard ratios (with 95% confidence intervals) for all-cause mortality were 2.00 (1.66 to 2.42), 2.92 (2.38 to 3.59), 4.07 (3.28 to 5.05), 6.77 (5.22 to 8.78), and 9.68 (7.18 to 13.00) in patients with hs-cTnT levels of 5 to 9, 10 to 14, 15 to 29, 30 to 49, and ≥50 ng/l, respectively, compared with patients with hs-cTnT levels <5 ng/l. There was a strong and graded association between all detectable levels of hs-cTnT and risk for MI, heart failure, and cardiovascular and noncardiovascular mortality. Among patients with chest pain and stable troponin levels, any detectable level of hs-cTnT is associated with an increased risk of death and cardiovascular outcomes and should merit further attention.
Modificações na imunidade antidiftérica específica para a idade, na Polónia nos últimos 40 anos
Authors: A Zakrzewska, A Galazka, D Rymkiewicz
Journal: Eurosurveillance (1997)

A epidemia massiva de difteria na Russia e Ucrânia que se disseminou a todos os Novos Estados Independentes (NEI) da antiga Uniao Sovietica (1-5) levantou receio de esta doenca se pudesse disseminara a outros paises. Esta preocupacao e justificavel uma vez que, em muitos paises industrializados, uma grande parte da populacao adulta se encontra insuficientemente imunizada contra a difteria.
Abstract 13320: Vascular Dysfunction Due to Sheath Insertion Into the Radial Artery
Authors: Tomoo Nakata, Satoshi Ikeda, Seiji Koga, Yuji Koide, Hiroaki Kawano, Koji Maemura
Journal: Circulation (2015)

Background: The transradial approach is widely used for coronary procedures. However, this procedure carries a risk of radial artery injury such as dissection, spasm and occlusion. We examined the vascular dysfunction caused by the transradial approach using reactive hyperemia peripheral arterial tonometry (RH-PAT), a recently used technique for evaluating endothelial function in digits, and compared the differences in injuries according to the size of sheath Mehods: Forty-three patients receiving transradial catheterization with 4-Fr/5-Fr (non-6Fr; n = 26) sheaths or 6Fr sheaths (n = 17) were enrolled. RH-PAT was evaluated using Endo-PAT2000 in the arm of sheath placement and in the other arm as a control before, at the day and 6 months (n = 16, 6-Fr group; n = 13, non-6-Fr group) after catheterization. Results: RH-PAT values decreased from 2.42 ± 0.67 before catheterization to 2.08 ± 0.41 at the day after catheterization in the 6-Fr group (p = 0.03), which was more evident in patients with a longer procedure time (&gt; 90 minutes). On the other hand, the change in the non-6-Fr group was not significant. RH-PAT of control side was unchanged in both groups. At 6 months after catheterization, RH-PAT values in 6-Fr group had not completely returned to baseline. Conclusions: The insertion of a 6-Fr catheter sheath into the radial artery, especially with a longer procedure time, impaired vascular endothelial function, which occurred at the day after the procedure and sustained after 6 months. Thus, we have to pay attention to the sheath size and procedure time at the transradial approach.