tbuckley/cabot-search huggingface dataset:
Pembrolizumab-Induced Extensive Panniculitis and Nevus Regression
Authors: Sara Burillo-Martinez, Carlos Morales-Raya, Marta Prieto-Barrios, Jose-Luis Rodriguez-Peralto, Pablo-Luis Ortiz-Romero
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Minimal impact of extensive heating of hen's egg and cow's milk in a food matrix on threshold dose‐distribution curves
Authors: B. C. Remington, J. Westerhout, D. E. Campbell, P. J. Turner
Journal: Allergy (2017)

Abstract We analyzed reaction threshold data from 352 children undergoing open food challenges to hen's egg or cow's milk, either fresh or extensively heated into a muffin. There was no significant shift in dose‐distribution curves due to the baking process, implying that existing threshold data for these allergens can be applied to allergen risk management, even when these allergens are heat‐processed into baked foods.
Unraveling the pain mechanisms in chronic pancreatitis: a study comparing visceral and somatic pain thresholds
Authors: G. Dimcevski, K.-P. Schipper, U. T. Jensen, P. F. Jensen, A. L. Krarup, N. Thorsgaard, Lars Arendt-Nielsen, Asbjørn Mohr Drewes
Journal: Gut (2003)
Possible effect of p53 codon 72 polymorphism on suscepitibility to skin cancer.
Authors: C A Harwood, T Crook, L Brooks, Sheila Fisher, D A Kelly, J O'Nions, Antony Young, T Surentheran, J Breuer, T P Millard, Cathryn Lewis, I M Leigh, A Storey, J M McGregor
Journal: British Journal of Dermatology (2001)
Early breast cancer management guidelines compliance: A single institutional review.
Authors: Mahvish Muzaffar, Iman Mohamed
Journal: Journal of Clinical Oncology (2014)

e11539 Background: Health care in United states of America is undergoing paradigm shift with Congress mandating that the Medicare program tie payment to reporting on quality measures.We undertook this study to assess the compliance of breast cancer care with established quality indicators from professional societies. Methods: We undertook a retrospective study at University of Toledo Medical Center(UTMC ) after IRB approval , which included patients with stage I/II breast cancer between 2006-2010. Percentage compliance with ASCO/NCCN Quality Measures was calculated. Radiation therapy administered within 1 year of diagnosis for women younger than age 70 years receiving breast conserving surgery. Combination chemotherapy is considered or administered within 4 months (120 days) of diagnosis with AJCC T1cN0M0, or stage II or III hormone receptor–negative breast cancer. Tamoxifen or third generation aromatase inhibitor is considered or administered within 1 year of diagnosis for ER positive tumors. Results: A total of 506 patients with Stage I /II breast cancer were identified between 2006-2010. 72% of patients were more than 50 years of age. 85% were white, 59% with stage I and 41% with Stage II cancer. 79.4% had ER positive,12% triple negative and 16.6% HER2 positive tumors. 60.5% patients underwent breast conservative surgery, 21.5% cancer side mastectomy and 18% bilateral mastectomy. Out of 264 patients eligible for local radiation therapy 251( 95%) received radiation within 1 year,13 patients did not receive RT.85% of patients eligible for chemotherapy completed treatment. 93.5% of patients eligible for endocrine therapy received while 6.5% did not receive( 11 declined, 13 not recommended by oncologist, 2 unknown reasons). Conclusions: The best approach to assess the quality of breast cancer care requires investigation of reasons for noncompliance with established guidelines.100% compliance for each measure is not the expected outcome, given that patients may not receive recommended care for reasons such as refusal or contraindications to treatment, which are not currently captured as exclusions in this set of measures University of Toledo medical center has acceptable compliance rates with these three quality indicators.
GnRH agonist for protection against ovarian toxicity during chemotherapy for early breast cancer: the Anglo Celtic Group OPTION trial
Authors: R.C.F. Leonard, D.J.A. Adamson, G. Bertelli, J. Mansi, A. Yellowlees, J. Dunlop, G.A. Thomas, R.E. Coleman, R.A. Anderson
Journal: Annals of Oncology (2017)
DSP-7888, a Novel Cocktail Design of WT1 Peptide Vaccine, and Its Combinational Immunotherapy with Immune Checkpoint-Blocking Antibody Against PD-1
Authors: Masashi Goto, Megumi Nakamura, Natsuko Suginobe, Hideo Takasu, Yosuke Takanashi, Hitoshi Ban, Chiang J Li
Journal: Blood (2016)
Differential requirements for molecular chaperones in the degradation of soluble and transmembrane substrates of the ubiquitin ligase Doa10 in ER associated degradation (ERAD)
Authors: Susanne Radke, Tommer Ravid, Stefan Kreft, Mark Hochstrasser
Journal: Cancer Research (2008)

1852  A tumor microenvironment of persistent hypoxia and low nutrient concentration, as well as an increased incidence of incorrectly folded proteins caused by genome instability, cause endoplasmic reticulum stress in cells of poorly vascularized solid tumors. The unfolded protein response (UPR) is crucial for cancer cells to avoid apoptosis; the UPR increases levels of key enzymes of protein quality control, including molecular chaperones, ubiquitin ligases and the 26S proteasome. The ER molecular chaperone Bip/GRP78, which is induced by the UPR, has been proposed as a predictive factor for therapeutic outcome in breast cancer patients. Patients with high level of GRP78 have been shown to be at higher risk for recurrence of the disease.  ER-associated protein degradation (ERAD) is responsible for the recognition, ubiquitination and degradation of misfolded proteins exposing hydrophobic patches that can form toxic aggregates in the ER, which leads to apoptosis. ERAD has been extensively studied in yeast, and two ubiquitin ligases in the ER membrane have been discovered. One of them is Doa10 (mammalian ortholog TEB4) that ubiquitinates substrates localized in the nucleus, in the cytosol and in the ER membrane. The exact mechanism how Doa10 is able to recognize this large variety of substrates is not yet understood.  Because ubiquitin ligases and molecular chaperones collaborate in protein quality control pathways, we aimed to analyze whether heat shock proteins (HSPs) are involved in substrate recognition by Doa10. We established a matched pair of soluble and transmembrane substrates for the ER ubiquitin ligase Doa10 in which both substrates carry a degron called Deg1, which is required for the Doa10-dependent degradation of the transcriptional repressor Matalpha2. We analyzed substrate degradation in different Hsp70, Hsp90 and Hsp40 yeast mutants and found that whereas the yeast Hsp70 Ssa1 is required for the degradation of both types of substrates, absence of its co-chaperone Ydj1 (yeast ortholog of the mammalian Hdj1) strongly stabilizes only the soluble substrate protein. The mutant ydj1-H34Q, which is incapable of enhancing ATPase activity in Hsp70, also prevents soluble Doa10 substrate degradation. Our results lead to the hypothesis that Ydj1 is strictly required for the recognition of soluble but not transmembrane substrates at the ER membrane.  It is likely that these findings can be translated from yeast to mammalian cells. If so, inhibiting the mammalian TEB4 pathway in cancer cells may provide a novel approach to cancer treatment, including breast cancer.
CYTOKINE BIOMARKER PROFILING IN ACETAMINOPHEN-INDUCED ACUTE LIVER FAILURE: IMPORTANCE OF MONOCYTE CHEMOTACTIC PROTEIN-1 IN PROGNOSIS AND HEPATIC ENCEPHALOPATHY
Authors: Charalambos G. Antoniades, Matthew J. Bruce, Mark McPhail, Srirajaskanthan Rajaventhan, Philip A. Berry, Munther J. Hussain, Christopher Willars, William Bernal, Georg Auzinger, Julia Wendon
Journal: Hepatology (2010)
A Pragmatic Randomized Controlled Trial Examining the Impact of the Retzius-sparing Approach on Early Urinary Continence Recovery After Robot-assisted Radical Prostatectomy
Authors: Deepansh Dalela, Wooju Jeong, Madhu-Ashni Prasad, Akshay Sood, Firas Abdollah, Mireya Diaz, Patrick Karabon, Jesse Sammon, Marcus Jamil, Brad Baize, Andrea Simone, Mani Menon
Journal: European Urology (2017)
Interm Report of the Highlow Study: A Randomized Controlled Trial Comparing Two Doses of Low Molecular Weight Heparin for the Prevention of Pregnancy-Associated Recurrent Venous Thromboembolism
Authors: Suzanne M Bleker, Bistervels M Ingrid, Andrea Buchmüller, Céline Chauleur, Fionnuala Ní Áinle, Jennifer Donnelly, Peter Verhamme, Anne Flem Jacobsen, Hervé Décousus, Saskia Middeldorp
Journal: Blood (2016)
Dose-Reduced Versus Standard Conditioning Followed by Allogeneic Stem-Cell Transplantation for Patients With Myelodysplastic Syndrome: A Prospective Randomized Phase III Study of the EBMT (RICMAC Trial)
Authors: Nicolaus Kröger, Simona Iacobelli, Georg-Nikolaus Franke, Uwe Platzbecker, Ruzena Uddin, Kai Hübel, Christof Scheid, Thomas Weber, Marie Robin, Matthias Stelljes, Boris Afanasyev, Dominik Heim, Giorgio Lambertenghi Deliliers, Francesco Onida, Peter Dreger, Massimo Pini, Stefano Guidi, Liisa Volin, Andreas Günther, Wolfgang Bethge, Xavier Poiré, Guido Kobbe, Marleen van Os, Ronald Brand, Theo de Witte
Journal: Journal of Clinical Oncology (2017)

Purpose To compare a reduced-intensity conditioning regimen (RIC) with a myeloablative conditioning regimen (MAC) before allogeneic transplantation in patients with myelodysplastic syndrome (MDS) within a randomized trial. Patients and Methods Within the European Society of Blood and Marrow Transplantation, we conducted a prospective, multicenter, open-label, randomized phase III trial that compared a busulfan-based RIC with MAC in patients with MDS or secondary acute myeloid leukemia. A total of 129 patients were enrolled from 18 centers. Patients were randomly assigned in a 1:1 ratio and were stratified according to donor, age, and blast count. Results Engraftment was comparable between both groups. The CI of acute graft-versus-host disease II to IV was 32.3% after RIC and 37.5% after MAC ( P = .35). The CI of chronic graft-versus-host disease was 61.6% after RIC and 64.7% after MAC ( P = .76). The CI of nonrelapse mortality after 1 year was 17% (95% CI, 8% to 26%) after RIC and 25% (95% CI, 15% to 36%) after MAC ( P = .29). The CI of relapse at 2 years was 17% (95% CI, 8% to 26%) after RIC and 15% (95% CI, 6% to 24%) after MAC ( P = .6), which resulted in a 2-year relapse-free survival and overall survival of 62% (95% CI, 50% to 74%) and 76% (95% CI, 66% to 87%), respectively, after RIC, and 58% (95% CI, 46% to 71%) and 63% (95% CI, 51% to 75%), respectively, after MAC ( P = .58 and P = .08, respectively). Conclusion This prospective, randomized trial of the European Society of Blood and Marrow Transplantation provides evidence that RIC resulted in at least a 2-year relapse-free survival and overall survival similar to MAC in patients with MDS or secondary acute myeloid leukemia.
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Authors: Åsmund T. Røe, Jan Magnus Aronsen, Kristine Skårdal, Nazha Hamdani, Wolfgang A. Linke, Håvard E. Danielsen, Ole M. Sejersted, Ivar Sjaastad, William E. Louch
Journal: Cardiovascular Research (2017)

Concentric hypertrophy following pressure-overload is linked to preserved systolic function but impaired diastolic function, and is an important substrate for heart failure with preserved ejection fraction. While increased passive stiffness of the myocardium is a suggested mechanism underlying diastolic dysfunction in these hearts, the contribution of active diastolic Ca2+ cycling in cardiomyocytes remains unclear. In this study, we sought to dissect contributions of passive and active mechanisms to diastolic dysfunction in the concentrically hypertrophied heart following pressure-overload. Rats were subjected to aortic banding (AB), and experiments were performed 6 weeks after surgery using sham-operated rats as controls. In vivo ejection fraction and fractional shortening were normal, confirming preservation of systolic function. Left ventricular concentric hypertrophy and diastolic dysfunction following AB were indicated by thickening of the ventricular wall, reduced peak early diastolic tissue velocity, and higher E/e' values. Slowed relaxation was also observed in left ventricular muscle strips isolated from AB hearts, during both isometric and isotonic stimulation, and accompanied by increases in passive tension, viscosity, and extracellular collagen. An altered titin phosphorylation profile was observed with hypophosphorylation of the phosphosites S4080 and S3991 sites within the N2Bus, and S12884 within the PEVK region. Increased titin-based stiffness was confirmed by salt-extraction experiments. In contrast, isolated, unloaded cardiomyocytes exhibited accelerated relaxation in AB compared to sham, and less contracture at high pacing frequencies. Parallel enhancement of diastolic Ca2+ handling was observed, with augmented NCX and SERCA2 activity and lowered resting cytosolic [Ca2+]. In the hypertrophied heart with preserved systolic function, in vivo diastolic dysfunction develops as cardiac fibrosis and alterations in titin phosphorylation compromise left ventricular compliance, and despite compensatory changes in cardiomyocyte Ca2+ homeostasis.
A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery
Authors: David R. Wilson, Denis Routkevitch, Yuan Rui, Arman Mosenia, Karl J. Wahlin, Alfredo Quinones-Hinojosa, Donald J. Zack, Jordan J. Green
Journal: Molecular Therapy (2017)

There is a need for new tools to better quantify intracellular delivery barriers in high-throughput and high-content ways. Here, we synthesized a triple-fluorophore-labeled nucleic acid pH nanosensor for measuring intracellular pH of exogenous DNA at specific time points in a high-throughput manner by flow cytometry following non-viral transfection. By including two pH-sensitive fluorophores and one pH-insensitive fluorophore in the nanosensor, detection of pH was possible over the full physiological range. We further assessed possible correlation between intracellular pH of delivered DNA, cellular uptake of DNA, and DNA reporter gene expression at 24 hr post-transfection for poly-L-lysine and branched polyethylenimine polyplex nanoparticles. While successful transfection was shown to clearly depend on median cellular pH of delivered DNA at the cell population level, surprisingly, on an individual cell basis, there was no significant correlation between intracellular pH and transfection efficacy. To our knowledge, this is the first reported instance of high-throughput single-cell analysis between cellular uptake of DNA, intracellular pH of delivered DNA, and gene expression of the delivered DNA. Using the nanosensor, we demonstrate that the ability of polymeric nanoparticles to avoid an acidic environment is necessary, but not sufficient, for successful transfection.
Mercury Poisoning at a Home Day Care Center — Hillsborough County, Florida, 2015
Authors: Mackenzie Tewell, Samantha Spoto, Michael Wiese, Alfred Aleguas, Tamas Peredy
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

On November 12, 2015, the Florida Poison Information Center Tampa notified the Florida Department of Health in Hillsborough County of a boy aged 3 years with a urine mercury level of 79 μg/L (normal <10 μg/L). The patient had been admitted to the hospital on October 9, 2015 after a 3-4 week history of anorexia, weight loss, and lethargy. In the hospital, he developed a maculopapular rash, acrodynia (painful, pink discoloration of the hands and feet), tachycardia, hypertension, weakness, sweating, excessive salivation, and altered mental status. Subsequent investigation identified the source of the mercury exposure to be a broken sphygmomanometer (blood pressure monitor) at the home day care center attended by the child.
Daratumumab, a Novel Human Anti-CD38 Monoclonal Antibody for the Treatment of Chronic Lymphocytic Leukemia and B-Cell Non–Hodgkin Lymphoma
Authors: Alba Matas-Céspedes, Anna Vidal-Crespo, Vanina Rodriguez, Gael Roue, Elias Campo, Dolors Colomer, Jeroen Lammerts van Bueren, Joost M Bakker, Adrian Wiestner, Paul W.H.I. Parren, Patricia Perez-Galan
Journal: Blood (2012)
Ipilimumab-Induced Organizing Pneumonia on 18F-FDG PET/CT in a Patient With Malignant Melanoma
Authors: Roy A. Raad, Rajni Kannan, Kathleen Madden, Anna Pavlick
Journal: Clinical Nuclear Medicine (2017)

A 60-year-old woman with history of vaginal malignant melanoma and inguinal nodal metastases underwent F-FDG PET/CT for restaging following ipilimumab (Yervoy) immunotherapy, a Food and Drug Administration-approved human monoclonal antibody targeting cytotoxic T-lymphocyte-associated antigen 4. PET/CT demonstrated mildly FDG-avid multifocal enlarging bilateral lung opacities. Within each lung lesion, there was circumferential uptake localizing to a high-attenuation rim with a photopenic ground-glass center on CT, consistent with "reversed halo sign." Patient was asymptomatic at the time of imaging. Ipilimumab was discontinued, and 3-month follow-up PET/CT revealed spontaneous complete resolution of the lung lesions, supporting the diagnosis of ipilimumab-induced organizing pneumonia.
Pattern of immune reconstitution after allograf T: Results of double blind randomised trial of allogene c bone marrow or peripheral blood stem cells transplantation
Authors: R. Powles, S. Kulkarni, J. Mehta, S. Singhai, B. Sirohi, R. Saso, S. Long, A. Rowland, J. Marsden, C. Horton, B. Millar, J. Treleaven
Journal: Blood (2000)
Mid-season real-time estimates of seasonal influenza vaccine effectiveness in persons 65 years and older in register-based surveillance, Stockholm County, Sweden, and Finland, January 2017
Authors: Maria-Pia Hergens, Ulrike Baum, Mia Brytting, Niina Ikonen, Anu Haveri, Åsa Wiman, Hanna Nohynek, Åke Örtqvist
Journal: Eurosurveillance (2017)

Systems for register-based monitoring of vaccine effectiveness (VE) against laboratory-confirmed influenza (LCI) in real time were set up in Stockholm County, Sweden, and Finland, before start of the 2016/17 influenza season, using population-based cohort studies. Both in Stockholm and Finland, an early epidemic of influenza A(H3N2) peaked in week 52, 2016. Already during weeks 48 to 50, analyses of influenza VE in persons 65 years and above showed moderately good estimates of around 50%, then rapidly declined by week 2, 2017 to 28% and 32% in Stockholm and Finland, respectively. The sensitivity analyses, where time since vaccination was taken into account, could not demonstrate a clear decline, neither by calendar week nor by time since vaccination. Most (68%) of the samples collected from vaccinated patients belonged to the 3C.2a1 subclade with the additional amino acid substitution T135K in haemagglutinin (64%) or to subclade 3C.2a with the additional haemagglutinin substitutions T131K and R142K (36%). The proportion of samples containing these alterations increased during the studied period. These substitutions may be responsible for viral antigenic change and part of the observed VE drop. Another possible cause is poor vaccine immunogenicity in older persons. Improved influenza vaccines are needed, especially for the elderly.
Annals Story Slam - Sit Up Straight
Authors: Karole Collier
Journal: Annals of Internal Medicine (2017)

Web Exclusives2 May 2017Annals Story Slam - Sit Up StraightFREEKarole CollierKarole CollierFrom Penn Medicine, Philadelphia, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W17-0047 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Sit Up Straight "Sit Up Straight," by Karole Collier (Duration 11:09)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: From Penn Medicine, Philadelphia, Pennsylvania.Current Author Address: Karole Collier, Penn Medicine, Philadelphia, PA; e-mail, Karole.[email protected]upenn.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 May 2017Volume 166, Issue 9Page: SS1 ePublished: 2 May 2017 Issue Published: 2 May 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.Loading ...
Extrusion Bioprinting of Shear‐Thinning Gelatin Methacryloyl Bioinks
Authors: Wanjun Liu, Marcel A. Heinrich, Yixiao Zhou, Ali Akpek, Ning Hu, Xiao Liu, Xiaofei Guan, Zhe Zhong, Xiangyu Jin, Ali Khademhosseini, Yu Shrike Zhang
Journal: Advanced Healthcare Materials (2017)

Bioprinting is an emerging technique for the fabrication of 3D cell-laden constructs. However, the progress for generating a 3D complex physiological microenvironment has been hampered by a lack of advanced cell-responsive bioinks that enable bioprinting with high structural fidelity, particularly in the case of extrusion-based bioprinting. Herein, this paper reports a novel strategy to directly bioprint cell-laden gelatin methacryloyl (GelMA) constructs using bioinks of GelMA physical gels (GPGs) achieved through a simple cooling process. Attributed to their shear-thinning and self-healing properties, the GPG bioinks can retain the shape and form integral structures after deposition, allowing for subsequent UV crosslinking for permanent stabilization. This paper shows the structural fidelity by bioprinting various 3D structures that are typically challenging to fabricate using conventional bioinks under extrusion modes. Moreover, the use of the GPG bioinks enables direct bioprinting of highly porous and soft constructs at relatively low concentrations (down to 3%) of GelMA. It is also demonstrated that the bioprinted constructs not only permit cell survival but also enhance cell proliferation as well as spreading at lower concentrations of the GPG bioinks. It is believed that such a strategy of bioprinting will provide many opportunities in convenient fabrication of 3D cell-laden constructs for applications in tissue engineering, regenerative medicine, and pharmaceutical screening.