Hepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus
Authors: Susan J. Bersoff-Matcha, Kelly Cao, Mihaela Jason, S. Christopher Jones, Allen Brinker
Journal: Annals of Internal Medicine (2017)

Letters21 November 2017Hepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C VirusSusan J. Bersoff-Matcha, MD, Kelly Cao, PharmD, Mihaela Jason, PharmD, S. Christopher Jones, PharmD, MS, MPH, and Allen Brinker, MD, MSSusan J. Bersoff-Matcha, MDU.S. Food and Drug Administration, Silver Spring, Maryland (S.J.B., K.C., M.J., S.C.J., A.B.)Search for more papers by this author, Kelly Cao, PharmDU.S. Food and Drug Administration, Silver Spring, Maryland (S.J.B., K.C., M.J., S.C.J., A.B.)Search for more papers by this author, Mihaela Jason, PharmDU.S. Food and Drug Administration, Silver Spring, Maryland (S.J.B., K.C., M.J., S.C.J., A.B.)Search for more papers by this author, S. Christopher Jones, PharmD, MS, MPHU.S. Food and Drug Administration, Silver Spring, Maryland (S.J.B., K.C., M.J., S.C.J., A.B.)Search for more papers by this author, and Allen Brinker, MD, MSU.S. Food and Drug Administration, Silver Spring, Maryland (S.J.B., K.C., M.J., S.C.J., A.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0477 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Mahale and colleagues postulate that HDV infection may have contributed to HBV reactivation in cases identified in our cohort. However, in our case series, there were no reports of HDV infection in either the U.S. Food and Drug Administration Adverse Event Reporting System database or the literature that we reviewed. A limitation of the database is that data may be missing, so we do not know whether results of serologic testing for HDV infection were negative or whether testing was not done. Therefore, we cannot exclude HDV co-infection as a contributing factor in HBV reactivation from the ...Reference1. Infectious Diseases Society of America/American Association for the Study of Liver Diseases. Recommendations for testing, managing, and treating hepatitis C. 2015. Accessed at http://hcvguidelines.org on 20 July 2017. Google Scholar Author, Article, and Disclosure InformationAffiliations: U.S. Food and Drug Administration, Silver Spring, Maryland (S.J.B., K.C., M.J., S.C.J., A.B.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-0377. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus: A Review of Cases Reported to the U.S. Food and Drug Administration Adverse Event Reporting System Susan J. Bersoff-Matcha , Kelly Cao , Mihaela Jason , Adebola Ajao , S. Christopher Jones , Tamra Meyer , and Allen Brinker Hepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus Parag Mahale , Jeffrey S. Glenn , and Thomas R. O’Brien Metrics Cited byHepatitis B surface antibody titres and hepatitis B reactivation with direct‐acting antiviral therapy for hepatitis CCare quality and outcomes among US veterans with chronic hepatitis B in the hepatitis C direct‐acting antiviral eraKidney disease in patients with chronic liver diseaseSummary of the 2018 Kidney Disease Improving Global Outcomes (KDIGO) Guideline on hepatitis C in chronic kidney diseaseReal-world treatment of hepatitis C with second-generation direct-acting antivirals: initial results from a multicentre Canadian retrospective cohort of diverse patients 21 November 2017Volume 167, Issue 10Page: 760KeywordsAntiviral therapyDatabasesHepatitis BHepatitis virusesInfectious diseasesInfectious hepatitisLiver diseasesMedical risk factorsPatientsTreatment guidelines ePublished: 21 November 2017 Issue Published: 21 November 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...