tbuckley/cabot-search huggingface dataset:
La borréliose de Lyme chronique et disséminée en Norvège, 1995-2004
Authors: K Nygård, A B Brantsaeter, R Mehl
Journal: Eurosurveillance (2005)

La borreliose de Lyme est l’infection liee aux tiques la plus courante en Norvege. Toutes les manifestations cliniques de cette maladie, hormis l’erytheme migrant, sont a declaration obligatoire aupres du Folkehelseinstituttet, l’institut norvegien de sante publique. Entre 1995 et 2004, un total de 1506 cas de borreliose de Lyme chronique et disseminee ont ete declares. Des analyses serologiques sont a la base du diagnostic de laboratoire dans presque tous les cas. Le nombre annuel de cas n’indique pas de tendance evidente pour la periode, mais il a varie chaque annee entre 120 et 253 cas, 2004 etant l’annee de plus grande incidence. Dans 75% des cas pour lesquels l’information etait disponible, les patients ont montre les premiers symptomes entre juin et octobre. Une variation geographique marquee est a noter dans les taux d’incidence rapportes, les taux les plus eleves concernant les regions cotieres du sud et du centre de la Norvege. Cinquante six pour cent des cas etaient des hommes et 44% des femmes. Les enfants entre cinq et neuf ans etaient les plus touches. La neuroborreliose etait la manifestation clinique la plus courante (71%), suivie par l’arthrite/arthralgie (22%) et l’acrodermatite chronique atrophiante (5%). Quarante six pour cent des patients ont ete hospitalises. Les mesures preventives contre la borreliose en Norvege visent a eviter les morsures de tiques, par le port de vetements couvrants et l’utilisation de produits insectifuges, ainsi qu’a la detection precoce et la suppression des tiques. En Norvege, les antibiotiques ne sont generalement pas recommandes comme mesure prophylactique apres une morsure de tiques.
Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior
Authors: Jorim J. Tielbeek, Ada Johansson, Tinca J. C. Polderman, Marja-Riitta Rautiainen, Philip Jansen, Michelle Taylor, Xiaoran Tong, Qing Lu, Alexandra S. Burt, Henning Tiemeier, Essi Viding, Robert Plomin, Nicholas G. Martin, Andrew C. Heath, Pamela A. F. Madden, Grant Montgomery, Kevin M. Beaver, Irwin Waldman, Joel Gelernter, Henry R. Kranzler, Lindsay A. Farrer, John R. B. Perry, Marcus Munafò, Devon LoParo, Tiina Paunio, Jari Tiihonen, Sabine E. Mous, Irene Pappa, Christiaan de Leeuw, Kyoko Watanabe, Anke R. Hammerschlag, Jessica E. Salvatore, Fazil Aliev, Tim B. Bigdeli, Danielle Dick, Stephen V. Faraone, Arne Popma, Sarah E. Medland, Danielle Posthuma
Journal: JAMA Psychiatry (2017)

Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified.
Transfer-molded wrappable microneedle meshes for perivascular drug delivery
Authors: JiYong Lee, Dae-Hyun Kim, Kang Ju Lee, Il Ho Seo, Seung Hyun Park, Eui Hwa Jang, Youngjoo Park, Young-Nam Youn, WonHyoung Ryu
Journal: Journal of Controlled Release (2017)
Toxinfecções alimentares colectivas a Norovirus, ligadas ao consumo de ostras do tanque de Thau, França, Dezembro de 2002
Authors: A Doyle, D Barataud, A Gallay, J M Thiolet, S Le Guyaguer, E Kohli, V Vaillant
Journal: Eurosurveillance (2004)

Em janeiro de 2003, o Institut de veille sanitaire recebeu notificacoes de surtos de gastroenterite provavelmente associados ao consumo de ostras cultivadas no tanque de Thau, no sul de Franca. Durante este mesmo periodo, um surto de mais de 200 casos associados a ostras que provinham do tanque de Thau era declarado em Italia. Um inquerito foi iniciado para determinar a fonte e o veiculo destes surtos. 
Uma analise descriptiva dos surtos declarados em Franca, uma analise microbiologica das amostras de fezes e de ostras, um genotipagem dos noroviruses, tanto como uma investigacao do medio ambiental do tanque de Thau foram realizadas. Um estudio de coorte retrospectivo tambem foi feito entre as pessoas que haviam participado a refeicoes familiares em Paris. 
Segundo os resultados da analise descritiva, 13 surtos familiares en quatro departamentos (69 casos) poderem ser atribuidos ao consumo de ostras de Thau. As ostras distribuidas no lugar de trabalho e logo consumidas em 14 refeicoes familiares entre o 19 e o 24 de dezembro causaram outra epidemia. A taxa de attaque era de 21/36 (58%) em aqueles que tinham consumido ostras e de 0/22 em aqueles que nao tinham consumido (p=0.00002).
Os noroviruses (genogrupos I e II) foram identificados nas amostras das fezes de quatro surtos de infeccao e nas ostras de trez surtos de infeccao (das quais em Paris). Os inqueritos ambientais mostraram a relacao entre as fortes precipitacoes, o desborde das estacoes de depuracao e a contaminacao fecal do tanque de Thau no mez de dezembro. As ostras de Thau foram responsaveis por varios surtos de gastroenterite a norovirus durante o inverno de 2002 em Franca e em Italia. 
Um pedido oficial de purificacao das ostras foi introduzido, visto os altos niveles de E.Coli encontrados na agua do tanque e dentro das conchas. Entretanto esta medida nao pode ser realizada por falta de um equipamento suficiente. Em conclusao, o inquerito permitiu uma mudanca na maneira de clasificar as areas de cultivo de mariscos em Franca.
Abstract 19499: In vivo Efficacy of the AKT Inhibitor ARQ092 in Noonan Syndrome With Multiple Lentigines-Associated Hypertrophic Cardiomyopathy
Authors: Vasanth Chandrasekhar, Jianxun Wang, James Cross, Giovanni Abbadessa, Yi Yu, Maria I Kontaridis
Journal: Circulation (2016)

Noonan Syndrome with Multiple Lentigines (NSML, formerly called LEOPARD syndrome) is an autosomal dominant “RASopathy” disorder manifesting in congenital heart disease. Most cases of NSML are caused by catalytically inactivating mutations in the protein tyrosine phosphatase (PTP), non-receptor type 11 (PTPN11) gene that encodes the SH2 domain-containing PTP-2 (SHP2). We generated knock-in mice harboring the  PTPN11  mutation Y279C, one of the most common NSML alleles; these SHP2 Y279C/+  mice recapitulated the human disorder, and developed hypertrophic cardiomyopathy (HCM) by 12 weeks of age. Moreover, heart and/or cardiomyocyte lysates from SHP2 Y279C/+  mice exhibited increased basal and agonist-induced AKT and mTOR activities. The purpose of this study was to assess whether the cardiac defects in SHP2 Y279C/+  mice were reversed by treatment with ARQ092, an AKT inhibitor in clinical trials for patients with PI3K/AKT-driven tumors or Proteus syndrome.  We obtained echocardiographs of SHP2 Y279C/+  and WT littermates, either in the presence or absence of ARQ092 at 12, 14, and 16 weeks of age. SHP2 Y279C/+  mice developed significant left ventricular hypertrophy, as indicated by decreased chamber dimension and increased posterior wall thickness compared with littermate controls which progressed over the course of the 4 week study. Treatment of SHP2 Y279C/+ mice with ARQ092 normalized the HCM as early as 2 weeks following treatment, with levels comparable to those in WT. No abnormal cardiac function was detected in hearts of WT mice, whether treated with vehicle or ARQ092. Interestingly, we observed an increase in fractional shortening (FS%) over time in the SHP2 Y279C/+  mice, an effect of compensatory hypertrophy; this was not apparent in SHP2 Y279C/+  mice treated with ARQ092, suggesting functional improvement upon treatment with the AKT inhibitor. SHP2 Y279C/+  mice also showed trending normalization in HW/TL ratios as compared to WT, suggesting this drug may be a novel therapy for treatment of HCM in NSML. Mechanistic studies are currently underway.
Hematopoietic stem cell transplantation rescues the hematological, immunological, and vascular phenotype in DADA2
Authors: Hasan Hashem, Ashish R. Kumar, Ingo Müller, Florian Babor, Robbert Bredius, Jignesh Dalal, Amy P. Hsu, Steven M. Holland, Dennis D. Hickstein, Stephen Jolles, Robert Krance, Ghadir Sasa, Mervi Taskinen, Minna Koskenvuo, Janna Saarela, Joris van Montfrans, Keith Wilson, Barbara Bosch, Leen Moens, Michael Hershfield, Isabelle Meyts
Journal: Blood (2017)
Functional ultrasound imaging of brain activity in human newborns
Authors: Charlie Demene, Jérome Baranger, Miguel Bernal, Catherine Delanoe, Stéphane Auvin, Valérie Biran, Marianne Alison, Jérome Mairesse, Elisabeth Harribaud, Mathieu Pernot, Mickael Tanter, Olivier Baud
Journal: Science Translational Medicine (2017)

Functional ultrasound imaging with high spatiotemporal resolution monitors brain function in babies.
Pandemia de gripe: planificación de la preparación en Alemania
Authors: R Fock, H Bergmann, H Bußmann, G Fell, E J Finke, U Koch, M Niedrig, M Peters, K Riedmann, D Scholz, A Wirtz
Journal: Eurosurveillance (2002)

El marco conceptual descrito en este articulo ha servido de base a la decision conjunta tomada por los ministros de sanidad de los dieciseis estados federales de Alemania, encaminada a definir un plan de preparacion contra la pandemia de gripe. Se utilizo el peor escenario, partiendo de los datos correspondientes a la pandemia de ‘gripe espanola’ de 1918-20. Se evaluaron los grupos con mayor prioridad de vacunacion, asi como los tratamientos antivirales potencialmente disponibles. Las politicas nacionales se verian enormemente favorecidas por una perspectiva europea en comun.
The Emotional Fallout From the Culture of Blame and Shame
Authors: Catherine Craun Ferguson
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Validity of skin cancer malignancy reporting to the Organ Procurement Transplant Network: A cohort study
Authors: Giorgia L. Garrett, Joyce T. Yuan, Thuzar M. Shin, Sarah T. Arron, Giorgia L. Garrett, Oscar Colegio, Clara Curiel, John R. Griffin, Conway C. Huang, Anokhi Jambusaria, Shang I. Brian Jiang, Justin J. Leitenberger, Rajiv I. Nijhawan, Shari Ochoa, Edit B. Olasz, Clark Otley, Arisa Elena Ortiz, Vishal Anil Patel, Melissa Pugliano-Mauro, Chrysalyne D. Schmults, Sarah E. Schram, Thuzar Shin, Seaver Soon, Teresa Soriano, Divya Srivastava, Jennifer Stein, Kara Sternhell-Blackwell, Stan Taylor, Allison Vidimos, Peggy Wu, Sarah T. Arron
Journal: Journal of the American Academy of Dermatology (2017)
Retention in Medical Care Among Insured Children with Diagnosed HIV Infection — United States, 2010–2014
Authors: Mary R. Tanner, Tim Bush, Steven R Nesheim, Paul J. Weidle, Kathy K. Byrd
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

In 2014, an estimated 2,477 children aged <13 years were living with diagnosed human immunodeficiency virus (HIV) infection in the United States (1). Nationally, little is known about how well children with a diagnosis of HIV infection are retained in medical care. CDC analyzed insurance claims data to evaluate retention in medical care for children in the United States with a diagnosis of HIV infection. Data sources were the 2010-2014 MarketScan Multi-State Medicaid and MarketScan Commercial Claims and Encounters databases. Children aged <13 years with a diagnosis of HIV infection in 2010 were identified using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnostic billing codes for HIV or acquired immunodeficiency syndrome (AIDS), resulting in Medicaid and commercial claims cohorts of 163 and 129 children, respectively. Data for each child were evaluated during a 36-month study period, counted from the date of the first claim containing an ICD-9-CM code for HIV or AIDS. Each child's consistency of medical care was assessed by evaluating the frequency of medical visits during the first 24 months of the study period to see if the frequency of visits met the definition of retention in care. Frequency of medical visits was then assessed during an additional 12-month follow-up period to evaluate differences in medical care consistency between children who were retained or not retained in care during the initial 24-month period. During months 0-24, 60% of the Medicaid cohort and 69% of the commercial claims cohort were retained in care, among whom 93% (Medicaid) and 85% (commercial claims) were in care during months 25-36. To identify areas for additional public health action, further evaluation of the objectives for national medical care for children with diagnosed HIV infection is indicated.
Vigilancia de la resistencia antimicrobiana en el hombre, productos alimenticios y ganado en Dinamarca
Authors: H C Wegener, F Bager, F M Aarestrup
Journal: Eurosurveillance (1997)

Un aumento generalizado en la resistencia antimicrobiana en bacterias patogenas, ha dado lugar a una preocupacion a nivel mundial en cuanto a que el uso indiscriminado de agentes antimicrobianos en la produccion animal puede estimular el desarrollo de bacterias resistentes o genes de resistencia que pueden ser transferidos a las bacterias que originan enfermedades en los seres humanos. En interes de la seguridad del consumidor y de la salud de animales y humanos, en 1995 los ministros daneses de Agricultura y Pesca y de Sanidad pidieron al 'Danish Veterinary Laboratory', la 'Danish Food Agency' y al 'Statens Serum Institut' que colaborasen en la vigilancia e investigacion de la resistencia antimicrobiana.
Deviations From Clinical Trials Registration in the ED-SAFE Study
Authors: Andrew James Amos
Journal: JAMA Psychiatry (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Highly Expressed Genes Are Preferentially Co-Opted for C4 Photosynthesis
Authors: Jose J Moreno-Villena, Luke T Dunning, Colin P Osborne, Pascal-Antoine Christin
Journal: Molecular Biology and Evolution (2017)

Novel adaptations are generally assembled by co-opting pre-existing genetic components, but the factors dictating the suitability of genes for new functions remain poorly known. In this work, we used comparative transcriptomics to determine the attributes that increased the likelihood of some genes being co-opted for C4 photosynthesis, a convergent complex trait that boosts productivity in tropical conditions. We show that independent lineages of grasses repeatedly co-opted the gene lineages that were the most highly expressed in non-C4 ancestors to produce their C4 pathway. Although ancestral abundance in leaves explains which genes were used for the emergence of a C4 pathway, the tissue specificity has surprisingly no effect. Our results suggest that levels of key genes were elevated during the early diversification of grasses and subsequently repeatedly used to trigger a weak C4 cycle via relatively few mutations. The abundance of C4-suitable transcripts therefore facilitated physiological innovation, but the transition to a strong C4 pathway still involved consequent changes in expression levels, leaf specificity, and coding sequences. The direction and amount of changes required for the strong C4 pathway depended on the identity of the genes co-opted, so that ancestral gene expression both facilitates adaptive transitions and constrains subsequent evolutionary trajectories.
Effect of antioxidant activity of caffeic acid with cyclodextrins using ground mixture method
Authors: Ryota Shiozawa, Yutaka Inoue, Isamu Murata, Ikuo Kanamoto
Journal: Asian Journal of Pharmaceutical Sciences (2017)

In the current study, we prepared a ground mixture (GM) of caffeic acid (CA) with α-cyclodextrin (αCD) and with β-cyclodextrin (βCD), and then comparatively assessed the physicochemical properties and antioxidant capacities of these GMs. Phase solubility diagrams indicated that both CA/αCD and CA/βCD formed a complex at a molar ratio of 1/1. In addition, stability constants suggested that CA was more stable inside the cavity of αCD than inside the cavity of βCD. Results of powder X-ray diffraction (PXRD) indicated that the characteristic diffraction peaks of CA and CD disappeared and a halo pattern was produced by the GMs of CA/αCD and CA/βCD (molar ratios = 1/1). Dissolution testing revealed that both GMs had a higher rate of dissolution than CA alone did. Based on the 1H-1H NOESY NMR spectra for the GM of CA/αCD, the vinylene group of the CA molecule appeared to be included from the wider to the narrower rim of the αCD ring. Based on spectra for the GM of CA/βCD, the aromatic ring of the CA molecule appeared to be included from the wider to the narrower rim of the βCD ring. This suggests that the structures of the CA inclusion complexes differed between those involving αCD rings and those involving βCD rings. Results of a DPPH radical-scavenging activity test indicated that the GM of CA/αCD had a higher antioxidant capacity than that of the GM of CA/βCD. The differences in the antioxidant capacities of the GMs of CA/αCD and CA/βCD are presumably due to differences in stability constants and structures of the inclusion complexes.
Epidemia de gripe española en 1918 en Ginebra, Suiza
Authors: C E Ammon
Journal: Eurosurveillance (2002)

En Ginebra, Suiza, la epidemia de gripe espanola afecto a mas del 50% de la poblacion. La mortalidad mas elevada tuvo lugar en personas de 20-49 anos de edad y en varones. El impacto socioeconomico fue muy importante, dado que la epidemia produjo trastornos graves, incluso en los servicios de salud. Esta epidemia muestra el impacto socioeconomico que puede acarrear la gripe y subraya la necesidad de la preparacion ante eventuales pandemias.
Is mIndy a mediator of energy metabolism reprogramming in hepatocellular carcinoma induced by interleukin‐6/signal transducer and activator of transcription 3 signaling?
Authors: Yan Chen, Zhen Zeng, Yinying Lu
Journal: Hepatology (2017)

Potential conflict of interest: Nothing to report. Author names in bold designate shared co‐first authorship. We read with great interest the recently published study by von Loeffelholz et al.1 on the role of mIndy (also called solute carrier family 13 member 5 [Slc13a5]) in nonalcoholic fatty liver disease. They found that mIndy was a target gene of interleukin‐6/signal transducer and activator of transcription 3 (IL‐6/STAT3) signaling. They also showed that mIndy was required for the citrate uptake and subsequent hepatic lipogenesis. As a key cytokine involved in inflammation and metabolic disorders, IL‐6 was also considered as a strong risk indicator for hepatocellular carcinoma (HCC)2 and a critical mediator of chronic inflammation related HCC development.3 IL‐6 can directly activate STAT3 in hepatocytes and promote the expression of several factors involved in blocking apoptosis and enhancing cell proliferation, such as Bcl‐xL, Mcl, Cyclin D, and c‐Myc.4 However, to facilitate the rapid proliferation of tumor cells, increased lipogenesis was required for cell membrane formation. mIndy, the transporter of citrate, could uptake citrate into hepatocytes and promote lipogenesis from citrate. So, the study by von Loeffelholz et al.1 provided a very possible and interesting hypothesis that IL‐6/STAT3 induced mIndy may not only regulate lipid metabolism in nonalcoholic fatty liver disease, but also support tumor cell growth in HCC. The hypothesis was supported by a recent study that knocking down of mIndy inhibited human HCC cell proliferation by disrupting energy homeostasis in vitro.5 Taken together, the oncogenic role of IL‐6/STAT3 signing was not only mediated by its the well‐known downstream antiapoptotic proteins and proliferation‐related cyclins, but factors that contributed to the remodeling of energy metabolism, such as mIndy, might be also needed to adapt the rapid cell proliferation in the development of HCC. In addition, although the contribution of mIndy in HCC cell growth was confirmed in vitro, whether Indy is required for HCC growth in vivo will be an interesting topic for further studies.
Treatment patterns, clinical characteristics, and outcomes of patients (pts) with metastatic pancreatic cancer (MPC) treated with nab-paclitaxel (nab-P) plus gemcitabine (GEM) in real-life practice: ANICE-Pac trial
Authors: A. Fernández, M. Salgado, A. García, E. Buxò, R. Vera, J. Adeva, P. Jiménez, G. Quintero, C. Llorca, M. Cañabate, L.J. López, A. Muñoz, P. Ramírez, P. González, C. López, M. Reboredo, E. Gallardo, M. Sánchez, J. Gallego, C. Guillén
Journal: Annals of Oncology (2017)
Hunger can be the driving force behind “relapse” of type 2 diabetes
Authors: David Marjot
Journal: BMJ (2017)

McCombie and colleagues discuss the remission of type 2 diabetes.1 When I was given the diagnosis of type 2 diabetes about five years ago, I decided to lose weight by dieting.

I lost 13 kg and now stay between 71 kg and 72 kg. My BMI is 24.3. My blood pressure has only once reached …
UCL laboratory that made artificial implants breached safety rules
Authors: Nigel Hawkes
Journal: BMJ (2017)

Artificial implants produced at University College London and used in operations on patients abroad were in breach of manufacturing regulations and had not been properly tested in animals, an independent inquiry has found.1

Stephen Wigmore, professor of transplantation surgery at the University of Edinburgh, and his inquiry team found a catalogue of errors at UCL, where windpipes, arteries, and tear ducts made from polymer were supplied by a laboratory that was not licensed to make clinical grade devices. This breach should be reported to the Medicines and Healthcare Products Regulatory Agency “as soon as possible,” the report concluded.

The artificial organs were made of a polymer called POSS-PCU, a polyurethane modified to imitate natural materials. Before implantation the plastic scaffolds were clothed in cells taken from the patient. The medical research charity the Wellcome Trust awarded grants for the development of these …
A Phase (Ph) 1 dose finding study of X4P-001 (an oral CXCR4 inhibitor) and axitinib in patients with advanced renal cell carcinoma (RCC)
Authors: D.F. McDermott, R.W. Joseph, T. Ho, U. Vaishampayan, S. Ali, M. Matrana, R. Alter, J. Edenfield, S. Blanchette, L. Gan, M.B. Atkins
Journal: Annals of Oncology (2017)