tbuckley/cabot-search huggingface dataset:
Context matters: How macroeconomic forces may alter the reception of negative emotions in art
Authors: Hal Ersner Hershfield, Adam Lee Alter
Journal: Behavioral and Brain Sciences (2017)

Abstract Menninghaus et al. offer a comprehensive model to explain why people pursue darker emotions in art, but we believe they underplay the considerable role of situational factors in driving these preferences. In particular, changing mood states are likely to shape artistic preferences, in large part because positive mood states act as a protective buffer against otherwise aversive experiences.
Primary care pedometer-based walking intervention: mixed-methods results from 3 year follow-up of PACE-UP cluster-randomised controlled trial
Authors: Charlotte Wahlich, Derek Cook, Sally Kerry, Elizabeth Limb, Christina Victor, Steve Iliffe, Michael Ussher, Peter Whincup, Ulf Ekelund, Julia Fox-Rushby, Cheryl Furness, Carole Beighton, Rebecca Normansell, Judith Ibison, Stephen DeWilde, Tess Harris
Journal: The Lancet (2017)
Abstract 16165: Addition of Pericardial Delayed Hyper-enhancement by Cardiac Magnetic Resonance Imaging Increases the Diagnostic Ability of Current Guidelines to Diagnose Recurrence Among Patients With Chronic Recurrent Pericarditis
Authors: Arnav Kumar, Kimi Sato, Edlira Yzeiraj, Lin Lin, Jorge Betancor, Craig Asher, Saqer Alkharabsheh, Brian P Griffin, Deborah Kwon, Allan L Klein
Journal: Circulation (2016)

Background: Current guidelines recommend diagnosing recurrence based on chest pain, pericardial rub, EKG changes and new/worsening pericardial effusion. We hypothesized that quantified pericardial ...
Vegetating Darier Disease Treated With Botulinum Toxin
Authors: Lidia Ossorio-García, Cristina Collantes-Rodríguez, Isabel Villegas-Romero, Mario Linares-Barrios
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Amsterdam to host EMA after Brexit triggers withdrawal from London
Authors: Gareth Iacobucci
Journal: BMJ (2017)

An artist’s impression of the new headquarters of the European Medicines Agency in Amsterdam, to be constructed specifically for the EMA in the south of the city



The European Medicines Agency will move from the UK to the Netherlands after Amsterdam was chosen ahead of Milan in a tiebreaker vote.

The relocation, a consequence of the UK’s impending withdrawal from the European Union, was decided after a vote by the 27 member states at the EU’s General Affairs Council on 20 November.

The EMA, which has been based in London since it was established in 1995 and currently employs nearly 900 staff, now has just …
A multicenter study of noninvasive genotyping and dynamic monitoring of ROS1+NSCLC receiving treatment with crizotinib by next generation sequencing
Authors: W. Wang, C. Xu, W. Zhuang, Z. Song, G. Lin, Y. Zhu, X. Chen, R. Chen, Y. Guan, X. Yi, Y. Chen, G. Chen, M. Fang, T. Lv, Y. Song
Journal: Annals of Oncology (2017)
Abstract 14017: Prognostic Impact of Peak Heart Rate During Exercise in Atrial Fibrillation
Authors: Kazufumi Aihara, Yuko Kato, Shinya Suzuki, Tokuhisa Uejima, Hiroaki Semba, Hiroto Kano, Shunsuke Matsuno, Hideaki Takai, Takayuki Otsuka, Yuji Oikawa, Kazuyuki Nagashima, Hajime Kirigaya, Koichi Sagara, Takashi Kunihara, Junji Yajima, Hitoshi Sawada, Tadanori Aizawa, Takeshi Yamashita
Journal: Circulation (2016)

Background and Aim: Heart rate (HR) during exercise is known to be associated with cardiovascular morbidity/mortality in sinus rhythm (SR). However, the relationship between HR profile during exercise and cardiovascular prognosis remain unknown well in patients with atrial fibrillation (AF). We previously reported that peak VO2 but not resting HR is an independent predictor for future heart failure (HF) events in patients with AF. The aim of this study was to investigate the relationships between HR profile during exercise and future heart failure (HF) events in patients with AF and those with SR simultaneously. Methods: We used the cohort from the single-hospital database between 2004 and 2013 (N=22,230). Of the total, 2,231 patients (AF; N=321, SR; N=1910) who underwent symptom-limited cardiopulmonary exercise testing were analyzed. HF events were defined as either hospitalization for HF or death from HF. They were categorized according to the quartiles of peak HR in each rhythm. Results: Significant positive relationships between peak HR quartiles and peak VO2 were observed in both groups (AF: p for trend &lt;0.001, SR: p for trend &lt;0.001). Peak HR quartiles were also apparently negatively associated with the incidence of HF events in both groups (Figure). In univariate analysis for HF events, peak HR was significantly related to HF events in both rhythms. Multivariate analysis showed that peak HR was a statistically significant predictor for HF events in the AF group even after adjusted for age, use of HR lowering drugs, left ventricular ejection fraction, organic heart disease and eGFR. However, in the SR group, predictive power of peak HR was weakened after the same adjustment. Conclusion: It was suggested that peak HR is an independently strong predictor for future HF events in patients with AF.
Vigilancia reforzada de enfermedades infecciosas : la experiencia de la copa mundial 2006 de la FIFA, Alemania
Authors: K Schenkel, C Williams, T Eckmanns, G Poggensee, J Benzler, J Josephsen, G Krause
Journal: Eurosurveillance (2006)

La copa mundial de futbol 2006 de la FIFA tuvo lugar en 12 ciudades alemanas entre el 9 de junio y el 9 de julio de 2006 . Se identifico la necesidad de hacer mas reactivo y sensible el sistema de vigilancia de las enfermedades infecciosas existente, para detectar a tiempo los eventos de salud que ocurriesen durante la copa mundial. En las 12 ciudades que acogian el campeonato, entre el 7 de junio y el 11 de julio de 2006, se llevo a cabo una vigilancia reforzada, basada en el sistema existente de notificacion obligatoria : transmision electronica diaria, en vez de semanal, de datos sobre los casos de enfermedades de declaracion obligatoria (de acuerdo a definiciones de caso) , y declaracion de todas las infecciones, independientemente de las definiciones de caso. Ademas, fueron examinadas la prensa especializada y general, y se reforzo la comunicacion entre los participantes y el sistema de vigilancia. El retraso mediano para la transmision de datos de notificacion desde la comunidad hasta al nivel federal fue reducido de tres a un solo dia. Se pudo asi detectar un brote de norovirus en el Centro internacional de radiotelevision en Munich, con 61 casos ligados epidemiologicamente en la primera semana tras el inicio de sintomas, y cuatro casos aislados asociados a la copa mundial, de los cuales dos respondian a criterios del Reglamento Sanitario Internacional. Despues de la copa mundial, todos los participantes de la vigilancia constataron que habia mejorado notablemente la comunicacion entre los diferentes niveles (local, de estado y federal). A diferencia de la mayoria de los responsables sanitarios de encuentros en masa de la ultima decada, no se llevo a cabo una vigilancia sindromica. Sin embargo, el refuerzo de la vigilancia de las enfermedades infecciosas facilito la deteccion rapida de eventos sanitarios durante la copa mundial de la FIFA. Recomendamos continuar con la transmision diaria de los datos de notificacion dentro del marco de la vigilancia rutinaria de las enfermedades infecciosas en Alemania.
PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer
Authors: Yinhui Yang, Yang Bai, Yundong He, Yu Zhao, Jiaxiang Chen, Linlin Ma, Yunqian Pan, Michael Hinten, Jun Zhang, R. Jeffrey Karnes, Manish Kohli, Jennifer J. Westendorf, Benyi Li, Runzhi Zhu, Haojie Huang, Wanhai Xu
Journal: Clinical Cancer Research (2017)

Abstract Purpose: Intratumoral androgen synthesis (IAS) is a key mechanism promoting androgen receptor (AR) reactivation and antiandrogen resistance in castration-resistant prostate cancer (CRPC). However, signaling pathways driving aberrant IAS remain poorly understood. Experimental Design: The effect of components of the AKT-RUNX2-osteocalcin (OCN)–GPRC6A–CREB signaling axis on expression of steroidogenesis genes CYP11A1 and CYP17A1 and testosterone level were examined in PTEN-null human prostate cancer cell lines. Pten knockout mice were used to examine the effect of Runx2 heterozygous deletion or abiraterone acetate (ABA), a prodrug of the CYP17A1 inhibitor abiraterone on Cyp11a1 and Cyp17a1 expression, testosterone level and tumor microenvironment (TME) remodeling in vivo. Results: We uncovered that activation of the AKT–RUNX2–OCN–GPRC6A–CREB signaling axis induced expression of CYP11A1 and CYP17A1 and testosterone production in PTEN-null prostate cancer cell lines in culture. Deletion of Runx2 in Pten homozygous knockout prostate tumors decreased Cyp11a1 and Cyp17a1 expression, testosterone level, and tumor growth in castrated mice. ABA treatment also inhibited testosterone synthesis and alleviated Pten loss-induced tumorigenesis in vivo. Pten deletion induced TME remodeling, but Runx2 heterozygous deletion or ABA treatment reversed the effect of Pten loss by decreasing expression of the collagenase Mmp9. Conclusions: Abnormal RUNX2 activation plays a pivotal role in PTEN loss-induced IAS and TME remodeling, suggesting that the identified signaling cascade represents a viable target for effective treatment of PTEN-null prostate cancer, including CRPC. Clin Cancer Res; 24(4); 834–46. ©2017 AACR.
Distinct Cellular Mechanisms Underlie Smooth Muscle Turnover in Vascular Development and Repair
Authors: Urmas Roostalu, Bashar Aldeiri, Alessandra Albertini, Neil Humphreys, Maj Simonsen-Jackson, Jason K.F. Wong, Giulio Cossu
Journal: Circulation Research (2017)

Vascular smooth muscle turnover has important implications for blood vessel repair and for the development of cardiovascular diseases, yet lack of specific transgenic animal models has prevented it's in vivo analysis.The objective of this study was to characterize the dynamics and mechanisms of vascular smooth muscle turnover from the earliest stages of embryonic development to arterial repair in the adult.We show that CD146 is transiently expressed in vascular smooth muscle development. By using CRISPR-Cas9 genome editing and in vitro smooth muscle differentiation assay, we demonstrate that CD146 regulates the balance between proliferation and differentiation. We developed a triple-transgenic mouse model to map the fate of NG2+CD146+ immature smooth muscle cells. A series of pulse-chase experiments revealed that the origin of aortic vascular smooth muscle cells can be traced back to progenitor cells that reside in the wall of the dorsal aorta of the embryo at E10.5. A distinct population of CD146+ smooth muscle progenitor cells emerges during embryonic development and is maintained postnatally at arterial branch sites. To characterize the contribution of different cell types to arterial repair, we used 2 injury models. In limited wire-induced injury response, existing smooth muscle cells are the primary contributors to neointima formation. In contrast, microanastomosis leads to early smooth muscle death and subsequent colonization of the vascular wall by proliferative adventitial cells that contribute to the repair.Extensive proliferation of immature smooth muscle cells in the primitive embryonic dorsal aorta establishes the long-lived lineages of smooth muscle cells that make up the wall of the adult aorta. A discrete population of smooth muscle cells forms in the embryo and is postnatally sustained at arterial branch sites. In response to arterial injuries, existing smooth muscle cells give rise to neointima, but on extensive damage, they are replaced by adventitial cells.
STK25 is a critical determinant in nonalcoholic steatohepatitis
Authors: M. Mahlapuu, M. Amrutkar, U. Chursa, E. Nuñez-Duran, J. Borén, B.R. Johansson, H.-U. Marschall, M. Blüher, E. Cansby
Journal: Journal of Hepatology (2017)
Predicting Subclinical Atherosclerosis in Low-Risk Individuals
Authors: Juan Miguel Fernández-Alvira, Valentín Fuster, Stuart Pocock, Javier Sanz, Leticia Fernández-Friera, Martín Laclaustra, Rodrigo Fernández-Jiménez, José Mendiguren, Antonio Fernández-Ortiz, Borja Ibáñez, Héctor Bueno
Journal: Journal of the American College of Cardiology (2017)

The ideal cardiovascular health score (ICHS) is recommended for use in primary prevention. Simpler tools not requiring laboratory tests, such as the Fuster-BEWAT (blood pressure [B], exercise [E], weight [W], alimentation [A], and tobacco [T]) score (FBS), are also available.The purpose of this study was to compare the effectiveness of ICHS and FBS in predicting the presence and extent of subclinical atherosclerosis.A total of 3,983 participants 40 to 54 years of age were enrolled in the PESA (Progression of Early Subclinical Atherosclerosis) cohort. Subclinical atherosclerosis was measured in right and left carotids, abdominal aorta, right and left iliofemoral arteries, and coronary arteries. Subjects were classified as having poor, intermediate, or ideal cardiovascular health based on the number of favorable ICHS or FBS.With poor ICHS and FBS as references, individuals with ideal ICHS and FBS showed lower adjusted odds of having atherosclerotic plaques (ICHS odds ratio [OR]: 0.41; 95% confidence interval [CI]: 0.31 to 0.55 vs.0.49; 95% CI: 0.36 to 0.66), coronary artery calcium (CACS) ≥1 (CACS OR: 0.41; 95% CI: 0.28 to 0.60 vs.0.53; 95% CI: 0.38 to 0.74), higher number of affected territories (OR: 0.32; 95% CI: 0.26 to 0.41 vs. OR: 0.39; 95% CI: 0.31 to 0.50), and higher CACS level (OR: 0.40; 95% CI: 0.28 to 0.58 vs. OR: 0.52; 95% CI: 0.38 to 0.72). Similar levels of significantly discriminating accuracy were found for ICHS and FBS with respect to the presence of plaques (C-statistic: 0.694; 95% CI: 0.678 to 0.711 vs. 0.692; 95% CI: 0.676 to 0.709, respectively) and for CACS ≥1 (C-statistic: 0.782; 95% CI: 0.765 to 0.800 vs. 0.780; 95% CI: 0.762 to 0.798, respectively).Both scores predict the presence and extent of subclinical atherosclerosis with similar accuracy, highlighting the value of the FBS as a simpler and more affordable score for evaluating the risk of subclinical disease.
Code status communication training in Canadian postgraduate oncology programs: A needs assessment survey.
Authors: Oren Hannun Levine, Sukhbinder K. Dhesy-Thind, Meghan McConnell, Melissa C. Brouwers, Som Mukherjee
Journal: Journal of Clinical Oncology (2017)

13 Background: Discussions with cancer patients on cardiopulmonary resuscitation directives, or ‘code status,’ are often led by trainees in oncology. This study was carried out across Canada to identify current educational practices and gaps in training for this communication skill. Methods: Medical and radiation oncology residents and program directors (PDs) from across Canada were invited to complete a survey. Questions addressed current teaching practices, perceived importance of this competency, satisfaction with current education and barriers to teaching code status discussion skills. Relative frequencies of categorical and ordinal responses were calculated. Results: Between November 2016 and February 2017, 95 residents (58.6% response rate [RR]) and 17 PDs (63% RR) completed surveys. Both oncology disciplines and trainees at all levels were represented. Only 54.1% and 48.3% of medical and radiation oncology residents, respectively, had experienced any form of code status communication training before entering an oncology program. During oncology training, 41.1% of residents expect to receive formal teaching on this topic and 47.1% of PDs endorsed inclusion of this topic in curricula. Only 20% of residents reported receiving any formal evaluation for this competency while 41.2% of program directors indicated that formal evaluations are provided. All PDs and 98% of residents positively endorsed the importance of this competency in residency and clinical practice. Among residents, 88% felt that more training would be beneficial, and 82.3% of PDs identified a need for new educational resources in this area. Lack of time, educational resources and evaluation tools were among the most commonly identified barriers to teaching (by PDs and trainees). Conclusions: Canadian medical and radiation oncology residency PDs and trainees feel that code status communication is an important competency, yet teaching and evaluation are limited in this area. Barriers to teaching and skill-building have been identified. Further work is underway to develop novel educational resources for code status communication training to include in postgraduate curricula.
Opioid switch and change of route of administration in palliative care cancer patients treated by morphine: Update of French guidelines.
Authors: Philippe Poulain, Nathalie Michenot, Sylvie Rostaing, Laurent Baron, Ivan Krakowski
Journal: Journal of Clinical Oncology (2017)

226 Background: In 2002 guidelines for the treatment of cancer pain (National Federation of French Cancer Centers) were adapted to the availability of drugs in France. In 2015, a group of experts nominated by the 3 French Societies involved in cancer pain (AFSOS, SFAP, SFETD: Supportive Care, Palliative Care and Pain Societies), reviewed these guidelines and established new ratios for morphine switching and/or changing the route of administration in patients whose pain was not adequately controlled. Methods: A review of the literature via Pubmed (key words: morphine, oxycodone, fentanyl, hydromorphone, methadone, tapentadol, pain, cancer, palliative care, opioid rotation, opioid switching, equianalgesic ratios) plus a manual search, led us to retain 43 original works containing good scientific evidence (methodology French Health Authority).Final approval for publishing was obtained from each of the aforementioned three scientific committees of the societies. Results: Experts explained why the theory of opioid rotation using fixed ratios was no longer appropriate for a secure practice. In the light of recent publications enhancing our knowledge on the efficacy of new drug switching ratios and for changing the route of administration of morphine, the group of experts recommended to use reconsidered switching ratios favoring security over efficacy, to minimize overdosing and adverse effects. Consequently, after the new conversion ratio (using slow release opioids) was applied, a second titration should be done by using normal release rescue formulations for breakthrough pain episodes. Conclusions: This work can be apply to an international situation (despite different drug availability amongst countries). A smartphone app is available for rapid and secure dose conversions and will be translated into English. The adequate opioid dose is obtained from a theoretical dose calculation adapted to patient’s personal situation and needs (second titration). Continuous updating of good practice guidelines may provide security and adequacy of prescription for adequate and safe pain relief for our patients, limiting overconsumption and risk of misuse.
Objective smartphone measurements of physical activity and fitness in patients with cancer.
Authors: Joeri A.J. Douma, Henk M.W. Verheul, Laurien Buffart
Journal: Journal of Clinical Oncology (2017)

132 Background: Optimal (study) treatment for patients with advanced cancer is influenced by their performance status (PS) before initiation of systemic therapy. An objective assessment of a patient’s physical function is difficult to make and is currently heavily depending on the estimation of their PS by the treating physician. Objectively measured physical activity (PA) and physical fitness (FIT) may be more predictive for survival and treatment tolerability than their PS. We hypothesize that an objective measurement may provide more accurate estimates of a patient’s physical function and thereby a better outcome of (study) treatment. Unfortunately, routine objective measurements are time consuming and costly. Therefore, we aimed to investigate the validity and reliability of smartphone measurements of PA and FIT in patients with cancer. Methods: At present, 56 ambulant patients with various types of cancer participated. Patients wore an accelerometer for 7, and an IPhone for 14 consecutive days to measure the mean number of steps per day. Patients performed a 6MWT twice with the use of an smartphone application in their home environment and once in a test environment in the hospital. To assess the validity, we calculated the intraclass correlation coefficient (ICC) between the accelerometer and the first week of the IPhone for PA, and between the 6MWT in the hospital and the home environment for FIT. To assess reliability, we calculated the ICC between the IPhone week 1 and 2 for PA, and between the first and second 6MWT in the home environment for FIT. Results: Validity was excellent for PA (ICC = 0.96,p &lt; 0.05) and low for FIT (ICC = 0.33,p &lt; 0.05). We found excellent reliability for PA (ICC 0.94,p &lt; 0.05) and FIT (ICC = 0.93,p &lt; 0.05). Conclusions: In this study we found that objective smartphone measurements of PA are valid and reliable. FIT assessments were reliable, but in its present form its validity was low. A prospective study has been initiated to investigate whether objectively measured PA and/or FIT, better predicts early trial discontinuation and survival than PS or patient-reported physical function.
P1.06-029 Epidemiologic, Clinical Characteristics and Therapeutic Strategy of Elderly NSCLC Patients Treated in a Single Institution
Authors: Michael Vaslamatzis, Elisavet Patila, Theodoros Tegos, Nektarios Alevizopoulos, Charalambos Zoumblios, Theodora Kapou, Charalambos Stathopoulos, Apostolos Laskarakis, Charalambos Zisis, Edvin Vasili
Journal: Journal of Thoracic Oncology (2017)