tbuckley/cabot-search huggingface dataset:
Sutura endoscópica (TORe) para tratar la reganancia ponderal tras bypass gástrico quirúrgico
Authors: E Espinet Coll, J Nebreda Durán, G López-Nava Breviere, M Galvao Neto, P Díaz Galán, JA Gómez Valero, C Vila Lolo, S Bacchiddu, I Bautista-Castaño, A Juan-Creix Comamala
Journal: Endoscopy (2017)

La cirugía bariátrica es la opción terapéutica más eficaz a largo plazo para la obesidad mórbida. Sin embargo, pasados varios años, muchos de estos pacientes pueden recuperar gran parte del peso perdido. La reintervención quirúrgica, en estos casos, conlleva una elevada morbi-mortalidad.
Analysis of Plasma Epstein-Barr Virus DNA in Nasopharyngeal Cancer After Chemoradiation to Identify High-Risk Patients for Adjuvant Chemotherapy: A Randomized Controlled Trial
Authors: Anthony T.C. Chan, Edwin P. Hui, Roger K.C. Ngan, Stewart Y. Tung, Ashley C.K. Cheng, Wai T. Ng, Victor H.F. Lee, Brigette B.Y. Ma, Hoi C. Cheng, Frank C.S. Wong, Herbert H.F. Loong, Macy Tong, Darren M.C. Poon, Anil T. Ahuja, Ann D. King, Ki Wang, Frankie Mo, Benny C.Y. Zee, K.C. Allen Chan, Y.M. Dennis Lo
Journal: Journal of Clinical Oncology (2018)

Purpose The contribution of adjuvant chemotherapy after chemoradiation therapy (CRT) in nasopharyngeal cancer (NPC) remains controversial. Plasma Epstein-Barr virus (EBV) DNA is a potential biomarker of subclinical residual disease in NPC. In this prospective, multicenter, randomized controlled trial, we used plasma EBV DNA to identify patients with NPC at a higher risk of relapse for adjuvant chemotherapy. Patients and Methods Eligible patients with histologically confirmed NPC of Union for International Cancer Control stage IIB to IVB, adequate organ function, and no locoregional disease or distant metastasis were screened by plasma EBV DNA at 6 to 8 weeks after radiotherapy (RT). Patients with undetectable plasma EBV DNA underwent standard surveillance. Patients with detectable plasma EBV DNA were randomly assigned to either adjuvant chemotherapy with cisplatin and gemcitabine for six cycles (arm 1) or observation (arm 2). Patients were stratified for primary treatment (RT v CRT) and stage (II/III v IV). The primary end point was relapse-free survival (RFS). Results Seven hundred eighty-nine patients underwent EBV DNA screening. Plasma EBV DNA was undetectable in 573 (72.6%) and detectable in 216 (27.4%); 104 (13.2%) with detectable EBV DNA were randomly assigned to arms 1 (n = 52) and 2 (n = 52). After a median follow-up of 6.6 years, no significant difference was found in 5-year RFS rate between arms 1 and 2 (49.3% v 54.7%; P = .75; hazard ratio for relapse or death, 1.09; 95% CI, 0.63 to 1.89). The level of post-RT plasma EBV DNA correlated significantly with the hazards of locoregional failure, distant metastasis, and death. Conclusion In patients with NPC with detectable post-RT plasma EBV DNA, adjuvant chemotherapy with cisplatin and gemcitabine did not improve RFS. Post-RT plasma EBV DNA level should be incorporated as the selection factor in future clinical trials of adjuvant therapy in NPC.
Abstract 20468: Self-Care Confidence Moderates the Relationship Between Marginalization and Self-Care Maintenance in Heart Failure Patients
Authors: Foster Osei Baah, Marguerite Daus, Kristen Sethares, Onome Osokpo, Jennifer Miller, Debra K Moser, Barbara Riegel
Journal: Circulation (2017)

Background: Marginalized individuals in society are less motivated to care for themselves. Adequate self-care behavior is known to improve outcomes in patients with heart failure (HF), but the rela...
Abstract 133: Transplantation Of Neurosphere-forming Stem Cells Into Circulating Blood Attenuates Acute Inflammatory Activation Of Both Brain And Spleen After Cerebrovascular Ischemic Injury.
Authors: Soon-Tae Lee, Kon Chu, Keun-Hwa Jung, Hee-Kwon Park, Jeong-Min Kim, Jae-Sung Lim, Se-Jeong Kim, Vit Nary Choe, Dong-Hyun Kim, Jin-Hee Kim, Jae-Joon Ban, Sang Kun Lee, Manho Kim, Jae-Kyu Roh
Journal: Circulation (2007)

Background and Objectives: Transplantation of neural progenitor cells (NPCs) has been studied to achieve the regeneration of damaged brain in experimental stroke models. Tissue ischemia induces systemic inflammatory activation, especially in spleen. However, the interaction between NPCs and immune/inflammatory cells has not been studied in ischemia models. In this study, we investigated whether NPC can attenuate cerebral and systemic inflammatory activation in focal cerebral ischemia. Methods: Focal cerebral ischemia was induced by intraluminal thread occlusion of the middle cerebral artery for 60 minutes (c57/bl6 adult male mice), and mouse NPC from primary neurosphere (1 million cells) or vehicle (PBS, control group) was injected via tail veins with cerebral reperfusion. Inflammatory cytokines were evaluated with RealTime-PCR at 22 hrs, and the weights of each spleen and thymus were measured. Results: Cerebral ischemia induced progressive atrophies of spleen and thymus when measured at 22 hr and 96 hr after ischemia. Intravenous injection of NPC accelerated these lymphoid organ atrophies, and the weights of spleen and thymus were significantly lower in NPC-injected mice at 96 hr after the ischemia compared to the vehicle injected mice. RealTime-PCR analysis using ischemic hemispheres and spleens showed reduced expressions of inflammatory cytokines, including TNF-alpha, IL-6, MIP-2, IL-13, FoxP3, IL-1beta, and IP10 in NPC-injected brains and spleens at 22 hr after the ischemia. Transplanted NPCs were detected in systemic organs, and mostly in spleen. NPC-injected mice showed reduced infarct volume and neurologic deficits. Conclusion: Intravenous transplantation of primary neuro-sphere cells in cerebral ischemia attenuated systemic inflammatory activation, which suggests that the immunomodulating property of neural progenitor cells can be applicable for preventing harmful inflammations after the tissue ischemia.
Microvesicles and ectosomes in angiogenesis and diabetes - message in a bottle in the vascular ocean
Authors: Michael Lichtenauer, Christian Jung
Journal: Theranostics (2018)

The pathogenesis of diabetes involves dysregulated gene expression on a pre-and posttranscriptional level.One key mechanism in the development and progression of diabetes is thought being a dysregulation of signalling mediators such as microRNAs.These microRNAs interfere with pathophysiological reactions in diabetes by affecting gene transcription, insulin resistance and endothelial dysfunction.Here, in this current issue, Stępień et al. analysed ectosomal miRNA patterns in patients with type 2 diabetes mellitus (T2DM) using different analytical techniques.The focus of the current analysis was to characterize pro-and anti-angiogenic signalling effects of ectosomal miRNAs revealing important pathophysiologic mechanisms and signalling in T2DM.
Valoración de viabilidad, eficacia y seguridad de la punción-aspiración con aguja fina por ecoendoscopia (USE-PAAF) de lesiones renales
Authors: C De La Serna, ST Law, M Cimavilla, B Madrigal, P Gil, I Peñas, P Diez, R Torres, H Núñez, M Pérez-Miranda
Journal: Endoscopy (2017)

La punción de masas renales se realiza habitualmente bajo control ecográfico o tomografía computadorizada (TC). En ocasiones este acceso resulta complejo o bien estas lesiones se detectan de forma incidental durante la USE. Analizamos viabilidad, indicaciones y resultados de la USE-PAAF de lesiones renales.
Challenging measles case definition: three measles outbreaks in three Health Regions of Portugal, February to April 2018
Authors: Gonçalo Figueiredo Augusto, Diogo Cruz, Andreia Silva, Natália Pereira, Bárbara Aguiar, Ana Leça, Elisabete Serrada, Paula Valente, Teresa Fernandes, Fernando Guerra, Paula Palminha, Elsa Vinagre, Sílvia Lopo, Rita Cordeiro, Emma Sáez-López, Maria Neto, Paulo Jorge Nogueira, Graça Freitas
Journal: Eurosurveillance (2018)

We report three simultaneous measles outbreaks with 112 confirmed cases in three Health Regions of Portugal, from February to April 2018. The mean age of cases was 30 years, 79% worked in a healthcare setting and 87% were vaccinated. Genotype B3 was identified in 84 cases from the three outbreaks. Primary cases in each outbreak were imported. Several cases presented with modified measles, highlighting the importance of rethinking the measles case definition for vaccinated cases.
Abstract 15074: Application of the AHA 17 Segment Model: Evaluation of Relative Segmental Mass of the Left Ventricle by Cardiac MRI
Authors: Tasnim Vira, Merril Knudtson, Naeem Merchant, Andrew G Howarth
Journal: Circulation (2012)

Background: The division of the left ventricle (LV) into 17 segments consisting of 6 basal, 6 mid, 4 apical and an apical cap has entered into widespread use. The individual segments are a priori c...
Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival
Authors: Weiqiang Li, Mridu Middha, Mesude Bicak, Daniel D. Sjoberg, Emily Vertosick, Anders Dahlin, Christel Häggström, Göran Hallmans, Ann-Charlotte Rönn, Pär Stattin, Olle Melander, David Ulmert, Hans Lilja, Robert J. Klein
Journal: European Urology (2018)
ENDOSCOPIC SUBMUCOSAL DISSECTION OF 328 LARGE COLORECTAL NEOPLASIAS: OUTCOME AND LEARNING CURVE FROM A SPECIALIZED CENTER IN EUROPE
Authors: CF Frimand Rönnow, N Uedo, E Toth, H Thorlacius
Journal: Endoscopy (2018)

Endoscopic submucosal dissection (ESD) allows en bloc resection of large colorectal lesions but ESD experience is limited outside Asia. The aim of this study was to evaluate the outcome and learning curve of ESD in the treatment of colorectal neoplasias in a European center.
Importance of Intelligence and Emotional Intelligence for Physicians
Authors: Emily Willoughby, Brian B. Boutwell
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Obesity Paradigm and Lifetime Risk of Cardiovascular Disease—Reply
Authors: Sadiya S. Khan, Mercedes R. Carnethon, Donald M. Lloyd-Jones
Journal: JAMA Cardiology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Anthony Fauci, MD: Working to End HIV/AIDS
Authors: Jennifer Abbasi
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HRG Tokushima: Molecular and Cellular Characterization of Histidine-Rich Glycoprotein (HRG) Deficiency
Authors: Toshio Shigekiyo, Hidemasa Yoshida, Kazuya Matsumoto, Hiroyuki Azuma, Sadao Wakabayashi, Shiro Saito, Kazuo Fujikawa, Takehiko Koide
Journal: Blood (1998)
The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension
Authors: Syed Rehan Quadery, Andrew J. Swift, Catherine G. Billings, Alfred A.R. Thompson, Charles A. Elliot, Judith Hurdman, Athanasios Charalampopoulos, Ian Sabroe, Iain J. Armstrong, Neil Hamilton, Paul Sephton, Sian Garrad, Joanna Pepke-Zaba, David P. Jenkins, Nicholas Screaton, Alexander M. Rothman, Allan Lawrie, Trevor Cleveland, Steven Thomas, Smitha Rajaram, Catherine Hill, Christine Davies, Christopher S. Johns, Jim M. Wild, Robin Condliffe, David G. Kiely
Journal: European Respiratory Journal (2018)

Pulmonary endarterectomy (PEA) is the gold standard treatment for operable chronic thromboembolic pulmonary hypertension (CTEPH). However, a proportion of patients with operable disease decline surgery. There are currently no published data on this patient group. The aim of this study was to identify outcomes and prognostic factors in a large cohort of consecutive patients with CTEPH.Data were collected for consecutive, treatment-naive CTEPH patients at the Pulmonary Vascular Disease Unit of the Royal Hallamshire Hospital (Sheffield, UK) between 2001 and 2014.Of 550 CTEPH patients (mean±sd age 63±15 years, follow-up 4±3 years), 49% underwent surgery, 32% had technically operable disease and did not undergo surgery (including patient choice n=72 and unfit for surgery n=63), and 19% had inoperable disease due to disease distribution. The 5-year survival was superior in patients undergoing PEA (83%) versus technically operable disease who did not undergo surgery (53%) and inoperable due to disease distribution (59%) (p<0.001). Survival was superior in patients following PEA compared with those offered but declining surgery (55%) (p<0.001). In patients offered PEA, independent prognostic factors included mixed venous oxygen saturation, gas transfer and patient decision to proceed to surgery.Outcomes in CTEPH following PEA are excellent and superior to patients declining surgery, and strongly favour consideration of a surgical intervention in eligible patients.
Overdosage during patient controlled analgesia
Authors: D H Elcock
Journal: BMJ (1994)

kPa (2 4 atmospheres absolute) 100% oxygen for 90 minutes three times daily for the first day and twice daily thereafter.5In cases of surgical delay for any reason and in cases in which the decision is taken not to operate, hyperbaric oxygen should be used immediately if it is available; this may also assist in distinguishing viable from non- viable tissue at subsequent surgery.The availability of hyperbaric oxygen facilities in Britain can be checked with the hyperbaric unit at
META-ANALYSIS INDICATES THAT ADD-ON DEVICES AND NEW ENDOSCOPES REDUCE COLONOSCOPY ADENOMA MISS RATE
Authors: P Gkolfakis, G Tziatzios, A Facciorusso, N Muscatiello, K Triantafyllou
Journal: Endoscopy (2018)

Several add-on devices and new generation endoscopes promise to improve colonoscopy's outcomes by detecting polyps “hidden” behind the colonic folds. We aimed to measure the effect of these new modalities on colonoscopy's adenoma miss rate by meta-analyzing data from individual studies.
Profiling the circulating miRnome reveals a temporal regulation of the bone injury response
Authors: Andreia M. Silva, Maria I. Almeida, José H. Teixeira, Cristina Ivan, Joana Oliveira, Daniel Vasconcelos, Nuno Neves, Cláudia Ribeiro-Machado, Carla Cunha, Mário A. Barbosa, George A. Calin, Susana G. Santos
Journal: Theranostics (2018)

Bone injury healing is an orchestrated process that starts with an inflammatory phase followed by repair and remodelling of the bone defect. The initial inflammation is characterized by local changes in immune cell populations and molecular mediators, including microRNAs (miRNAs). However, the systemic response to bone injury remains largely uncharacterized. Thus, this study aimed to profile the changes in the plasma miRnome after bone injury and determine its biological implications. Methods: A rat model of femoral bone defect was used, and animals were evaluated at days 3 and 14 after injury. Non-operated (NO) and sham operated animals were used as controls. Blood and spleen were collected and peripheral blood mononuclear cells (PBMC) and plasma were separated. Plasma miRnome was determined by RT-qPCR array and bioinformatics Ingenuity pathway analysis (IPA) was performed. Proliferation of bone marrow mesenchymal stem/stromal cells (MSC) was evaluated by Ki67 staining and high-throughput cell imaging. Candidate miRNAs were evaluated in splenocytes by RT-qPCR, and proteins found in the IPA analysis were analysed in splenocytes and PBMC by Western blot. Results: Bone injury resulted in timely controlled changes to the miRNA expression profile in plasma. At day 3 there was a major down-regulation of miRNA levels, which was partially recovered by day 14 post-injury. Interestingly, bone injury led to a significant up-regulation of let-7a, let-7d and miR-21 in plasma and splenocytes at day 14 relative to day 3 after bone injury, but not in sham operated animals. IPA predicted that most miRNAs temporally affected were involved in cellular development, proliferation and movement. MSC proliferation was analysed and found significantly increased in response to plasma of animals days 3 and 14 post-injury, but not from NO animals. Moreover, IPA predicted that miRNA processing proteins Ago2 and Dicer were specifically inhibited at day 3 post-injury, with Ago2 becoming activated at day 14. Protein levels of Ago2 and Dicer in splenocytes were increased at day 14 relative to day 3 post-bone injury and NO animals, while in PBMC, levels were reduced at day 3 (albeit Dicer was not significant) and remained low at day 14. Ephrin receptor B6 followed the same tendency as Ago2 and Dicer, while Smad2/3 was significantly decreased in splenocytes from day 14 relative to NO and day 3 post-bone injury animals. Conclusion: Results show a systemic miRNA response to bone injury that is regulated in time and is related to inflammation resolution and the start of bone repair/regeneration, unravelling candidate miRNAs to be used as biomarkers in the monitoring of healthy bone healing and as therapeutic targets for the development of improved bone regeneration therapies.
Assessing predictive accuracy for outcomes of ventilator-associated events in an international cohort: the EUVAE study
Authors: Sergio Ramírez-Estrada, Leonel Lagunes, Yolanda Peña-López, Amir Vahedian-Azimi, Saad Nseir, Kostoula Arvaniti, Aliye Bastug, Izarne Totorika, Nefise Oztoprak, Lilla Bouadma, Despoina Koulenti, Jordi Rello
Journal: Intensive Care Medicine (2018)
Effects of coronary revascularization on global coronary flow reserve in stable coronary artery disease
Authors: Tadao Aikawa, Masanao Naya, Masahiko Obara, Osamu Manabe, Keiichi Magota, Kazuhiro Koyanagawa, Naoya Asakawa, Yoichi M Ito, Tohru Shiga, Chietsugu Katoh, Toshihisa Anzai, Hiroyuki Tsutsui, Venkatesh L Murthy, Nagara Tamaki
Journal: Cardiovascular Research (2018)

Coronary flow reserve (CFR) is an integrated measure of the entire coronary vasculature, and is a powerful prognostic marker in coronary artery disease (CAD). The extent to which coronary revascularization can improve CFR is unclear. This study aimed to evaluate the impact of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) on CFR in patients with stable CAD.In a prospective, multicentre observational study, CFR was measured by 15O-water positron emission tomography as the ratio of stress to rest myocardial blood flow at baseline and 6 months after optimal medical therapy (OMT) alone, PCI, or CABG. Changes in the SYNTAX and Leaman scores were angiographically evaluated as indicators of completeness of revascularization. Follow-up was completed by 75 (25 OMT alone, 28 PCI, and 22 CABG) out of 82 patients. The median SYNTAX and Leaman scores, and baseline CFR were 14.5 [interquartile range (IQR): 8-24.5], 5.5 (IQR: 2.5-12.5), and 1.94 (IQR: 1.67-2.66), respectively. Baseline CFR was negatively correlated with the SYNTAX (ρ = -0.40, P < 0.001) and Leaman scores (ρ = -0.33, P = 0.004). Overall, only CABG was associated with a significant increase in CFR [1.67 (IQR: 1.14-1.96) vs. 1.98 (IQR: 1.60-2.39), P < 0.001]. Among patients with CFR <2.0 (n = 41), CFR significantly increased in the PCI [1.70 (IQR: 1.42-1.79) vs. 2.21 (IQR: 1.78-2.49), P = 0.002, P < 0.001 for interaction between time and CFR] and CABG groups [1.28 (IQR: 1.13-1.80) vs. 1.86 (IQR: 1.57-2.22), P < 0.001]. The reduction in SYNTAX or Leaman scores after PCI or CABG was independently associated with the percent increase in CFR after adjusting for baseline characteristics (P = 0.012 and P = 0.011, respectively).Coronary revascularization ameliorated reduced CFR in patients with obstructive CAD. The degree of improvement in angiographic CAD burden by revascularization was correlated with magnitude of improvement in CFR.
Cortical Coding of Auditory Features
Authors: Xiaoqin Wang
Journal: Annual Review of Neuroscience (2018)

How the cerebral cortex encodes auditory features of biologically important sounds, including speech and music, is one of the most important questions in auditory neuroscience. The pursuit to understand related neural coding mechanisms in the mammalian auditory cortex can be traced back several decades to the early exploration of the cerebral cortex. Significant progress in this field has been made in the past two decades with new technical and conceptual advances. This article reviews the progress and challenges in this area of research.