tbuckley/cabot-search huggingface dataset:
Abstract 21219: Predictors of Heart Failure Readmission in a High Risk Population
Authors: Beverly A Carlson, Helina Hoyt, Kristi Gillespie, Julie Kunath, Lisa Bratzke
Journal: Circulation (2017)

Introduction: High risk for readmission in heart failure (HF) patients is associated with Hispanic ethnicity, multi-morbidity, and hospitals serving low socioeconomic or heavily Hispanic regions or with limited cardiac services. Information for hospitals caring primarily for such high-risk patients is lacking. Objective: To explore and describe the characteristics of patients hospitalized for acute heart failure and identify factors associated with 30-day HF readmission in a heavily Hispanic, rural, low-income community hospital near the California-Mexico border. Methods: Retrospective chart review of all patients admitted for HF within a two-year period was used to gather patient characteristics, presentation, previous one-year emergency department (ED) and hospital visits, medical therapy, and discharge status. Univariate analyses with student t-tests, Wilcoxon rank, and chi-square analysis as appropriate were used to identify factors associated with 30-day readmission. Logistic regression was used to identify independent predictors. Results: A total of 215 patients experienced 288 HF hospitalizations. Patients were primarily Hispanic (72%), male (58%), and obese (56%) with a mean age of 69 years, preserved ejection fraction (52%), and four or more chronic comorbid conditions (80%). In the prior 6 months, most (53%) had an ED visit and 28% had been hospitalized. The sample had high rates of hypertension (89%), diabetes (59%), hyperlipidemia (47%), renal disease (34%), and mental health disorders (18%). Median length of stay was two days and two (.9%) patients died. In the 189 patients discharged alive and with 30-day data, 69% were classified as high risk for early readmission by a commonly used clinical risk assessment metric (LACE score). Ten (5.3%) patients were readmitted for HF within 30 days. Number of ED visits in the previous six months (OR 1.5, p=.009) and atrial fibrillation at discharge (OR 5.7, p=.039) were independent predictors of 30-day HF readmission. Conclusions: Prior ED use and atrial fibrillation predicted early HF readmission following hospital discharge. These data provide support for a clinically useful alternative to standardized risk assessment tools in heavily Hispanic, multi-morbid, low-income HF patients.
Do patient tracking, follow-up, and referral practices contribute to breast cancer disparities in a large urban area?
Authors: Christine B. Weldon, Julia R. Trosman, Danielle Dupuy, Betty Roggenkamp, Julian C. Schink, Jennifer M. Orsi, Anne Marie Murphy
Journal: Journal of Clinical Oncology (2012)

6120 Background: Chicago Black women are 62% more likely to die from breast (BC) cancer than White women. Previous data from 39 Chicago hospitals suggested significant quality deficits in breast cancer screening and treatment (Chicago Breast Cancer Quality Consortium, 2010). Patient tracking, follow up and referral practices may influence quality of care for minority women (Mojica et al, Cancer Control, 2007). Our goal is to evaluate tracking, follow up and referral practices during screening, diagnosis and treatment of BC at Chicago hospitals servicing Black women. Methods: Using the framework approach of qualitative research, we conducted interviews with providers of BC screening and care from 20 Chicago institutions with Black patients averaging 50% of patient base (15 community, 3 academic and 2 public hospitals). Informants included surgeons, medical oncologists, radiologists, mammography technicians, internists, nurses, administrators, and patient navigators. Interviews were transcribed, and thematic and statistical analyses were performed (simple frequencies and Fisher's exact test). Results: Six of the 20 sites (30%) follow up with patients who did not show for a scheduled mammography visit. Five of these sites (83%, 5/6) have a low “no-show” rate (below 20%), compared to 4 sites (29%, 4/14) with low “no-show” rates among the 14 sites without follow-up (p=0.05). Seven of the 20 sites (25%) direct diagnosed patients to their next step in care by providing referrals and guidance, while other 13 sites rely on a primary care physician or leave the patient without a clear care plan. BC patients at 6 of the 7 sites directing care (83%, 5/6) are referred to a mid- or high-volume surgeon (3+ BC surgeries / month), compared to patients from only 1 of the 13 sites not directing care (p=0.001). Nine of the 20 sites track diagnosed BC patients through their care. Five of them (56%, 5/9) also track survivors, compared to none (0%, 0/11) of the 11 sites who do not track patients (p=0.008). Conclusions: Poor tracking, follow up and referral practices for breast cancer screening and treatment are associated with suboptimal care and may contribute to outcome disparities for Black women in Chicago.
人工弁機能不全(Stuck valve)の診断に心エコーが有用だった一例
Authors: 小林智子, 木島洋一, 瀬尾俊彦, 大竹寛雅, 戸田常紀, 川平敏博, 岩橋和彦, 神田裕史, 竹内陽史郎
Journal: Circulation (2002)
Driver mutations and prognosis in primary myelofibrosis: Mayo‐Careggi MPN alliance study of 1,095 patients
Authors: Ayalew Tefferi, Maura Nicolosi, Mythri Mudireddy, Natasha Szuber, Christy M. Finke, Terra L. Lasho, Curtis A. Hanson, Rhett P. Ketterling, Animesh Pardanani, Naseema Gangat, Carmela Mannarelli, Tiziana Fanelli, Paola Guglielmelli, Alessandro M. Vannucchi
Journal: American Journal of Hematology (2017)

Abstract The 2013 discovery of calreticulin ( CALR ) mutations in myeloproliferative neoplasms was attended by their association with longer survival in primary myelofibrosis (PMF). Subsequent studies have suggested prognostic distinction between type 1/like and type 2/like CALR mutations and detrimental effect from triple‐negative mutational status. Among 709 Mayo Clinic patients with PMF, 467 (66%) harbored JAK2 , 112 (16%) CALR type 1/like, 24 (3.4%) CALR type 2/like, 38 (5.4%) MPL mutations and 68 (10%) were triple‐negative. Survival was longer with type 1/like CALR , compared to JAK2 (HR 2.6, 95% CI 1.9‐3.5), type 2/like CALR (HR 2.5, 95% CI 1.4‐4.5), MPL (HR 1.8, 95% CI 1.1‐2.9) and triple‐negative mutational status (HR 2.4, 95% CI 1.6‐3.6), but otherwise similar between the non‐type 1/like CALR mutational states ( P = .41). In multivariable analysis, the absence of type 1/like CALR ( P &lt; .001; HR 2, 95% CI 1.4‐2.7), presence of ASXL1 / SRSF2 mutations ( P &lt; .001; HR 1.9, 95% CI 1.5‐2.4) and DIPSS‐plus ( P &lt; .001) were each predictive of inferior survival. Furthermore, among 210 patients with ASXL1 / SRSF2 mutations, survival was significantly longer in the presence vs. absence of type 1/like CALR mutations (median 5.8 vs. 2.9 years; P &lt; .001). Triple‐negative status did not disclose additional prognostic information for overall or leukemia‐free survival. The observations regarding the prognostic distinction between CALR mutation variants were validated in an external cohort of 386 patients from the University of Florence Careggi hospital. We conclude that type 1/like CALR mutations in PMF not only predict superior survival, but also partially amend the detrimental effect of high molecular risk mutations.
Suicide risk in persons with colorectal cancer: A population-based study.
Authors: Aileen Deng, Atrayee Basu Mallick
Journal: Journal of Clinical Oncology (2017)

196 Background: Patients with cancer have nearly twice the incidence of suicide compared to the general population. To date, identifying patients at risk for suicide remains challenging. Colorectal cancer (CRC) is the third most common cancer in the US. The purpose of this study was to identify risk factors associated with higher suicide rates (SR) among patients with CRC. Methods: A retrospective analysis was completed using Surveillance, Epidemiology, and End Results data from 1973 to 2014. Comparisons with the general US population were based on US mortality data collected by the National Center for Health Statistics. Suicide incidence, rates and standardized mortality ratio (SMR) were obtained by SEER*Stat 8.3.4. Results: Among 414788 patients with CRC observed for 2785811 person-years, 747 suicides were identified, for an adjusted SR of 26.7/100,000 person-years (SMR 1.40 [95% CI 1.30-1.50]). Higher SRs were associated with male sex, non-white or non-black race, being unmarried and having advanced disease at diagnosis (Table 1). SR was highest in the first year after diagnosis (SMR 2.00 [95% CI 1.68-2.37]) and with increasing age at diagnosis among unmarried patients. In patients 60 to 64 years at diagnosis, SR was highest in unmarried men (SMR 3.72 [95% CI 2.61-5.15]) and lowest in married women (SMR 0.61 [95% CI 0.17-1.57]). Conclusions: CRC is one of the most common cancers in the US. Patients with CRC have a 1.5-fold increase in SR compared to the general population. Suicide screening should especially target those in their first year after diagnosis, particularly older, unmarried patients. [Table: see text]
Thigh Cuffs as a Countermeasure for Ocular Changes in Simulated Weightlessness
Authors: Siva Balasubramanian, Tudor Tepelus, Michael B. Stenger, Stuart M.C. Lee, Steven S. Laurie, John H.K. Liu, Alan H. Feiveson, SriniVas R. Sadda, Alex S. Huang, Brandon R. Macias
Journal: Ophthalmology (2017)
Everolimus (EVE) + letrozole (LET) in Asian patients with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2−) advanced breast cancer (ABC): Results of a subgroup analysis from the BOLERO-4 study
Authors: T. Toyama, J. Jeong, V. Srimuninnimit, V. Sriuranpong, W. Noh, K. Tsugawa, M. Takahashi, H. Iwase, C. Arce, A. Ridolfi, C. Lin, M. Royce, F. Cardoso
Journal: Annals of Oncology (2017)
NICE to ban mesh for vaginal wall prolapse
Authors: Jacqui Wise
Journal: BMJ (2017)

Transvaginal mesh should not be used to treat vaginal wall prolapse, because of “serious but well recognised safety concerns,” says draft procedural guidance from the UK National Institute for Health and Care Excellence seen by The BMJ .

The guidance from NICE’s Interventional Procedure Advisory Committee, due to be published on 20 December, concluded that transvaginal mesh repair of anterior or posterior vaginal wall prolapse should be used only in the context of research. NICE said that its guidance had not yet been officially released and was subject to change.

The draft procedural guidance said that data from randomised controlled trials showed no added benefit of using mesh over native tissue repair. It added that when complications occurred these could be serious and have life changing consequences. Evidence of long term effectiveness was inadequate in quality and quantity, it said. Further research was needed, it concluded, which should include details of selection of patients, long term outcomes, including complications, the type of mesh used and method of fixation, and measures of quality …
Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness
Authors: Shan Wan, Anne‐Sophie Meyer, Sofia Maria Elisabeth Weiler, Christian Rupp, Marcell Tóth, Carsten Sticht, Stephan Singer, Stefan Thomann, Stephanie Roessler, Marina Schorpp‐Kistner, Jennifer Schmitt, Norbert Gretz, Peter Angel, Darjus Felix Tschaharganeh, Jens Marquardt, Peter Schirmacher, Federico Pinna, Kai Breuhahn
Journal: Hepatology (2017)

The loss of epithelial cell polarity plays an important role in the development and progression of liver cancer. However, the specific molecular mechanisms supporting tumor initiation and progression are poorly understood. In this study, transcriptome data and immunofluorescence stains of tissue samples derived from hepatocellular carcinoma (HCC) patients revealed that overexpression associated with cytoplasmic localization of the basolateral cell polarity complex protein scribble (Scrib) correlated with poor prognosis of HCC patients. In comparison with HCC cells stably expressing wild‐type Scrib (Scrib WT ), mutated Scrib with enforced cytoplasmic enrichment (Scrib P305L ) induced AKT signaling through the destabilization of phosphatase and tensin homolog (PTEN) and PH domain and leucine‐rich repeat protein phosphatase 1 (PHLPP1). Cytoplasmic Scrib P305L stimulated a gene signature and a phenotype characteristic for epithelial to mesenchymal transition (EMT) and HCC cell invasiveness. Scrib P305L ‐dependent invasion was mediated by the activator protein 1 (AP‐1) constituents ATF2 and JunB through induction of paracrine‐acting secreted protein acidic and cysteine‐rich (SPARC). Coexpression of Scrib P305L and the oncogene c‐MYC through hydrodynamic gene delivery in mouse livers promoted tumor formation and increased abundance of pAKT, pATF2, and SPARC in comparison with controls. Finally, cytoplasmic Scrib localization correlated with AKT and ATF2 phosphorylation in human HCC tissues, and the Scrib P305L ‐dependent gene signature was enriched in cancer patients with poor prognosis. Conclusion: Perturbation of hepatocellular polarity due to overexpression and cytoplasmic enrichment of Scrib supports tumor initiation and HCC cell dissemination through specific molecular mechanisms. Biomarker signatures identified in this study can be used for the identification of HCC patients with higher risk for the development of metastasis. (H epatology 2018;67:1842‐1856).
Gaze gesture based human robot interaction for laparoscopic surgery
Authors: Kenko Fujii, Gauthier Gras, Antonino Salerno, Guang-Zhong Yang
Journal: Medical Image Analysis (2017)

While minimally invasive surgery offers great benefits in terms of reduced patient trauma, bleeding, as well as faster recovery time, it still presents surgeons with major ergonomic challenges. Laparoscopic surgery requires the surgeon to bimanually control surgical instruments during the operation. A dedicated assistant is thus required to manoeuvre the camera, which is often difficult to synchronise with the surgeon's movements. This article introduces a robotic system in which a rigid endoscope held by a robotic arm is controlled via the surgeon's eye movement, thus forgoing the need for a camera assistant. Gaze gestures detected via a series of eye movements are used to convey the surgeon's intention to initiate gaze contingent camera control. Hidden Markov Models (HMMs) are used for real-time gaze gesture recognition, allowing the robotic camera to pan, tilt, and zoom, whilst immune to aberrant or unintentional eye movements. A novel online calibration method for the gaze tracker is proposed, which overcomes calibration drift and simplifies its clinical application. This robotic system has been validated by comprehensive user trials and a detailed analysis performed on usability metrics to assess the performance of the system. The results demonstrate that the surgeons can perform their tasks quicker and more efficiently when compared to the use of a camera assistant or foot switches.
Evaluation of art therapy on mood, anxiety, and pain levels in patients with cancer undergoing chemotherapy treatment.
Authors: Marie Doll, Steven Gale Roshon, Elizabeth Rodriguez Stone, Robert Sam Butler
Journal: Journal of Clinical Oncology (2017)

e21713 Background: Art therapy is a mental health modality that uses art-making to improve the physical, mental, and emotional wellbeing of individuals for a variety of purposes. The primary purpose of the trial is to assess the effect of art therapy on cancer patients' mood, anxiety, and pain levels. Secondary endpoints include exploring difference in response to art therapy by specific patient characteristics. Methods: Trial enrolled 50 cancer patients receiving chemotherapy. They participated in an hour long art therapy session with Art Therapist. Patients completed four visual analog scales (VAS) at three different time points: pre-treatment, post treatment (immediately after session) and 48-72 hours after session. Primary end points are pre and post session changes in the VAS for distress, depression, anxiety and pain. Secondary endpoints include differences in VAS scores by ethnic groups (Hispanic vs non-Hispanic), race (white vs non-white), age, gender, and marital status. Analysis was performed using repeated measures, mixed models, and pairwise means comparisons for the four measurements using the Tukey-Kramer adjustments for multiple comparisons. Results: Study revealed a statistically significant difference between pre treatment and post treatment as well as pre-treatment and follow up across distress, depression, anxiety and pain. There was no statistically significant difference between post treatment and follow up. The only significant correlation seen among patient characteristics was that Hispanic patients had higher depression scores at all time points vs non-Hispanics. Conclusions: Art therapy improved mood, anxiety and pain among all patients. Benefits were seen immediately after session and persisted at least 48-72 hours across all groups equally. Hispanic patients had higher depression scores compared to non-Hispanics. Clinical trial information: NCT02659345. [Table: see text]
Pet Rats Infect Daughter, Mother With Hantavirus
Authors: Rita Rubin
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasound Molecular Imaging of VEGFR-2 in Clear-Cell Renal Cell Carcinoma Tracks Disease Response to Antiangiogenic and Notch-Inhibition Therapy
Authors: Juan D Rojas, Fanglue Lin, Yun-Chen Chiang, Anna Chytil, Diana C Chong, Victoria L Bautch, W Kimryn Rathmell, Paul A Dayton
Journal: Theranostics (2017)

Metastatic clear-cell renal cell carcinoma (ccRCC) affects thousands of patients worldwide each year. Antiangiogenic therapy has been shown to have beneficial effects initially, but resistance is eventually developed. Therefore, it is important to accurately track the response of cancer to different therapeutics in order to appropriately adjust the therapy to maximize efficacy. Change in tumor volume is the current gold standard for determining efficacy of treatment. However, functional variations can occur much earlier than measurable volume changes. Contrast-enhanced ultrasound (CEUS) is an important tool for assessing tumor progression and response to therapy, since it can monitor functional changes in the physiology. In this study, we demonstrate how ultrasound molecular imaging (USMI) can accurately track the evolution of the disease and molecular response to treatment.
La rete di sorveglianza internazionale Enter-net - come funziona
Authors: I. S.T. Fisher
Journal: Eurosurveillance (1999)

Enter-net e una rete internazionale per la sorveglianza delle infezioni gastrointestinali umane che include salmonellosi ed isolamenti di Escherichia coli produttori di Vero citotossina (VTEC) O157, considerandone anche la resistenza antimicrobica. All'inizio la rete ha coinvolto tutti i 15 paesi dell'Unione Europea (UE), oltre alla Svizzera e alla Norvegia (mappa). La rete e finanziata dalla Commissione Europea (CE) e costituisce un'estensione della rete di sorveglianza Salm-net (1994-97) che era dedicata all'armonizzazione delle diverse tipizzazioni di salmonella mediante fagotipi e alla formazione di un archivio internazionale di isolati di salmonella, aggiornato con regolarita. Il riconoscimento dei focolai e le indagini compiute dalla rete Salm-net hanno dimostrato che lo scambio tempestivo di informazioni tra gli esperti dei diversi paesi europei possono consentire efficaci interventi di sanita pubblica, sia all'interno che all'esterno dell'Europa. La rete Enter-net continua ad estendere questi benefici alla prevenzione delle infezioni da E. coli O157.
Allergen Concerns and Popular Skin Care Products
Authors: Christina L. Harview, Jennifer L. Hsiao
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Response to: ‘Uric acid and incident dementia: a population-based cohort study’ by Lee and Song
Authors: Augustin Latourte, Aicha Soumaré, Thomas Bardin, Stéphanie Debette, Pascal Richette
Journal: Annals of the Rheumatic Diseases (2017)

We thank Drs Lee and Song for their interest and comments concerning our recent population-based cohort study investigating the relationship between serum uric acid (SUA) levels and dementia in elderly patients.1 2 They shared their concerns about the association that we found between higher SUA levels at baseline and an increased risk of incident vascular or mixed dementia. As discussed in our paper, these findings contradict a previous prospective study conducted in the Rotterdam cohort, which suggested that higher SUA levels were associated with a decreased risk of dementia and better cognitive function later in life.3 

Drs Lee and Song highlighted that the association between higher SUA levels …
Inheritance of Susceptibility to Spontaneous Pulmonary Tumors in Mice
Authors: Heston, W. E.
Journal: JNCI Journal of the National Cancer Institute (1942)

Journal Article Inheritance of Susceptibility to Spontaneous Pulmonary Tumors in Mice Get access W. E. Heston W. E. Heston geneticist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 3, Issue 1, August 1942, Pages 79–82, https://doi.org/10.1093/jnci/3.1.79 Published: 01 August 1942