tbuckley/cabot-search huggingface dataset:
High-dose versus weekly cisplatin definitive chemoradiotherapy for HPV-related oropharyngeal squamous cell carcinoma of the head and neck.
Authors: Cesar Augusto Perez, Xiaoyong Wu, Mark J. Amsbaugh, Wederson M. Claudino, Mehran Yusuf, Teresa Roberts, Jorge Arturo Rios-Perez, Dharamvir Jain, Alfred Jenson, Sujita Khanal, Craig I. Silverman, Paul Tennant, Neal E Dunlap, Shesh Rai, Rebecca A. Redman
Journal: Journal of Clinical Oncology (2016)

6074 Background: Definitive concurrent chemoradiation (CRT) is a standard treatment for patients (pts) with squamous cell carcinoma of the oropharynx (SCCOPx). We compared the outcomes and toxicity of high-dose cisplatin (HDC) versus weekly (WC) definitive CRT for patients with HPV-related SCCOPx. Methods: All pts with p16 positive SCCOPx treated with definitive CRT with cisplatin between 2010 and 2014 at a single institution were reviewed. CTCAE v 4.03 toxicity criteria was used. The Kaplan-Meier method was used to estimate event-free survival (EFS) and the overall survival (OS). Results: Of the55 pts included, 85% were males and 57% had a history of smoking > 10 pack-years. Median age at diagnosis was 55.4 years (40.3-80.0 years). 22 pts were treated with HDC at doses of 100 mg/m2 on days 1 and 22; 33 were treated with WC at 40 mg/m2. Groups were well balanced in respect to sex (p = 0.454) and smoking history (p = 0.799). The median total dose of cisplatin was 200 mg/m2 for both cohorts, with a mean of 195 mg/m2 for the HDC group and 189 mg/m2 for the WC group. At median follow-up of 27 months, there was one local failure and no distant failures in the HDC cohort. In the WC group, there were 6 total failures (2 local and 4 distant). Estimated 2-year EFS was better in HDC cohort as compared to WC (96% vs. 75%; p = 0.05), despite a longer follow-up in pts with HDC (32 months vs. 19 months). There was no significant difference in 2-year OS (95% vs. 94%; p = 0.4). In terms of toxicity, weight loss was marginally higher in the HDC arm compared to WC arm; all weight loss grades (100% vs 87%, p = 0.12) and weight loss > grade 1 (77% vs 60%; p = 0.19). However, gastric tube dependence at six months following therapy was similar (13% vs. 12%, p = 1.0). Acute renal injury of any grade was higher in HDC group (55% vs. 36%, p = 0.18) but grade 3 or 4 hematological toxicity was similar (20% vs 23%, p = 0.76). Conclusions: HPV-positive SCCOPx treated with definitive CRT with either HDC or WC had similar toxicity profile for several parameters. HDC has better EFS when compared with WC and this seems to be driven by increased distant failure rates, although the OS was similar. A longer follow-up will be needed to better assess if the OS remains similar.
Docosahexaenoic acid mediates susceptible cell death through differential regulation of p62/p-eIF2alpha/NRF2 in LMP1-expressing nasopnaryngeal carcinoma cells
Authors: K. Lim, K. Jing, S. Shin, S-H. Han, Y-S. Yoo, Y-J. Jeon, J-Y. Heo, G-R. Kweon, S-K. Park, J-I. Park
Journal: Annals of Oncology (2017)
Sorveglianza della variante della malattia di Creutzfeldt-Jakob nel Regno Unito
Authors: H J T Ward
Journal: Eurosurveillance (2000)

Alla fine di maggio di quest’anno risultavano nel Regno Unito 54 casi certi e 13 casi probabili di nvMCJ, identificati dalla National CJD Surveillance Unit (NCJDSU), istituita nel 1990. Tutti i casi certi sui quali sono disponibili dati, sono omozigoti per la metionina al codone 129 del gene della proteina prionica (PrP). Questa unita operativa, oltre alla gestione della sorveglianza a livello nazionale, ha partecipato a progetti di collaborazione come EUROCJD e NEUROCJD, finanziati dall'Unione Europea, che hanno l'obiettivo di confrontare i dati dei diversi paesi allo scopo di identificare nuovi fattori di rischio.
GW28-e0043 Relationship Between Ventricular Tachycardia Occurrence and Sympathetic Innervation and Myocardial Perfusion Disorders in Patients With the Coronary Artery Disease and Implantable Cardioverter Defibrillator
Authors: Tariel Atabekov, Svetlana Sazonova, Roman Batalov, Michail Khlynin, Sergey Popov
Journal: Journal of the American College of Cardiology (2017)
Relationship between tumor infiltrating lymphocyte (TIL) levels and response to pembrolizumab (pembro) in metastatic triple-negative breast cancer (mTNBC): Results from KEYNOTE-086
Authors: S. Loi, S. Adams, P. Schmid, J. Cortés, D.W. Cescon, E.P. Winer, D.L. Toppmeyer, H.S. Rugo, M. De Laurentiis, R. Nanda, H. Iwata, A. Awada, A. Tan, A. Wang, G. Aktan, V. Karantza, R. Salgado
Journal: Annals of Oncology (2017)
Effect of vitamin A and beta carotene supplementation on women's health
Authors: S. F Olsen
Journal: BMJ (1999)

A large field trial conducted in Nepal confirmed a beneficial effect of vitamin A and beta carotene supplementation on maternal mortality. Maternal deaths during pregnancy or within 12 weeks of delivery occurred at rates of 704/100,000 pregnancies (51/7241) in women who received a placebo, 426/100,000 pregnancies (33/7747) in women who received a single oral vitamin A supplement per week, and 361/100,000 pregnancies (26/7201) among those who received weekly oral beta carotene. The relative risks of pregnancy-related mortality were 0.60 (95% confidence interval (CI), 0.37-0.97) for vitamin A and 0.51 (95% CI, 0.30-0.86) for beta carotene. Before widespread vitamin A and beta carotene supplementation programs are implemented, further evaluation is required of the possible hazards to women of childbearing age and their offspring. For example, exposure to vitamin A during pregnancy has been linked to fetal malformations and schizophrenia.
Brote de criptosporidiosis en los Países Bajos
Authors: I. A. van Asperen, T Mank, G. J. Medema, C Stijnen, A S de Boer, J. F. Groot, P TenHam, J. F. Sluiters, M W Borgdorff
Journal: Eurosurveillance (1996)

En un hospital especializado en microbiologia de Spijkenisse, al sudoeste de los Paises Bajos -que recientemente habia participado en un curso de parasitologia - se identificaron oocistos criptosporidicos en las heces de un paciente con diarrea el 16 de agosto de 1.995. Un nuevo analisis de 89 muestras de heces recibidas desde el 10 de agosto en las cuales no se habia identificado ningun agente patogeno bacteriano, revelo 15 casos de criptosporidiosis posteriormente confirmados en el laboratorio de parasitologia de la Universidad de Leiden (Dr. A.M. Polderman). La mayoria de los casos fueron ninos menores de 5 anos de edad y mujeres entre 25-35 anos, ninguno de los cuales presentaba deficiencia inmunologica.
Early estimates of the excess mortality associated with the 2008-9 influenza season in Portugal
Authors: P J Nogueira, B Nunes, A Machado, E Rodrigues, V Gómez, L Sousa, J  M Falcão
Journal: Eurosurveillance (2009)

The aim of this study was to estimate the excess mortality associated with the influenza activity registered in Portugal between week 49 of 2008 and week 5 of 2009. For this purpose available mortality data from the Portuguese Daily Mortality Monitoring (VDM) System were used. Several estimates of excess deaths associated with the recent recorded influenza activity were determined through statistical modelling (cyclic regression) for the total population and disaggregated by gender and age group. The results show that the impact of the 2008-9 influenza season was 1,961 excess deaths, with approximately 82% of these occurring in the age group of 75 years and older.
Basal Cell Carcinoma in an Elderly Man
Authors: Jason M. Lunt, Ahmad Al-Taee, Fred R. Buckhold
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Development of an international core outcome set for peripheral vascular malformations: the OVAMA project
Authors: S.E.R. Horbach, C.M.A.M. van der Horst, F. Blei, C.J.M. van der Vleuten, I.J. Frieden, G.T. Richter, S.T. Tan, T. Muir, A.J. Penington, L.M. Boon, P.I. Spuls
Journal: British Journal of Dermatology (2017)

An important limitation in vascular malformation research is the heterogeneity in outcome measures used for the evaluation of treatment outcome. To reach international consensus on a core outcome set (COS) for clinical research on peripheral vascular malformations: lymphatic (LM), venous (VM) and arteriovenous malformations (AVM). In this consensus study, we determined what domains should constitute the COS. Thirty‐six possibly relevant outcome domains were proposed to an international group of physicians, patients and the parents of patients. In a three‐round e‐Delphi process using online surveys, participants repeatedly rated the importance of these domains on a five‐point Likert scale. Participants could also propose other relevant domains. This process was performed for LM, VM and AVM separately. Consensus was predefined as 80% agreement on the importance of a domain among both the physician group and the patient/parent group. Outcomes were then re‐evaluated in an online consensus meeting. 167 physicians and 134 patients and parents of patients with LM (n = 50), VM (n = 71) and AVM (n = 29) participated in the study. After three rounds and a consensus meeting, consensus was reached for all three types of vascular malformations on the core domains of radiological assessment, physician‐reported location‐specific signs, patient‐reported severity of symptoms, pain, quality of life, satisfaction and adverse events. Vascular malformation type‐specific signs and symptoms were included for LM, VM and AVM, separately. Our recommendation is that therapeutic‐efficacy studies on peripheral vascular malformations should measure at least these core outcome domains.
Um surto de infecção por Salmonella enteritidis, associado a bolo gelado
Authors: P D'Argenio, A Romano, F Autorino
Journal: Eurosurveillance (1999)

Apos um banquete de primeira comunhao, em Benevento, uma cidade de 60 000 habitantes no sul de Italia, diversas pessoas adoeceram com sintomas de gastrenterite. Estiveram no banquete, no dia 14 de Junho de 1998, entre as 14 e 18 horas, cerca de 60 pessoas. As autoridades de saude publica foram notificadas do surto por um medico de clinica geral a 16 de Junho e iniciaram, imediatamente, uma investigacao para identificar o agente causal, os alimentos contaminados e as possiveis falhas na sua preparacao.
A phase II randomized, double-blind study of sipuleucel-T followed by IDO pathway inhibitor, indoximod, or placebo in the treatment of patients with metastatic castration resistant prostate cancer (mCRPC).
Authors: Gautam Gopalji Jha, Shilpa Gupta, Scott T. Tagawa, Joseph S Koopmeiners, Sithara Vivek, Arkadiusz Z. Dudek, Sarah A. Cooley, Bruce R. Blazar, Jeffrey S. Miller
Journal: Journal of Clinical Oncology (2017)

3066 Background: The indoleamine 2,3-dioxygenase (IDO) pathway is a key counter-regulatory mechanism exploited by tumors in order to prevent and defeat anti-tumor immunity. Sipuleucel-T has overcome this tumor mediated anergy only in part by its ex-vivo sensitization. Small-molecule inhibitors of the IDO pathway, such as indoximod, are an increasingly validated class of potential cancer therapeutics. We tested the hypothesis whether targeting the IDO pathway by indoximod will inhibit Treg and abrogate tumor-mediated immunosuppression permitting a robust and sustained immune response to sipuleucel-T. Methods: Patient (pts) with mCRPC received either indoximod or placebo orally for 10 weeks after completion of sipuleucel-T therapy. In the absence of radiographic or clinical progression, pts were continued on study drug for 3 more months. Immune monitoring was done similar to IMPACT study (NEJM 2010; 363:411-422) starting prior to sipuleucel-T therapy. The primary endpoint was augmentation of immune response to PA2024 measured at 14 weeks. Secondary endpoints include safety, clinical efficacy (PFS, OS) and HR-QOL Results: Of the 63 pts with CRPC screened, 46 eligible pts were randomized to indoximod (n = 22) or placebo (n = 24). Pts tolerated therapy with indoximod with no significant difference in adverse events between two arms. There was no difference in PSA progression nor difference in the primary endpoint of immune response to PA2024 for 35 pts who have completed study and have samples analyzed. Median OS has not yet been reached in the study. Median radiographic PFS was 10.3 months in the treatment arm vs 4.1 months in placebo arm (p = 0.011), 4.1 months being similar to PFS in the pivotal ‘IMPACT’ study. More Pts continued to complete maximum treatment on indoximod arm (40.9% vs 25%). Conclusions: Treatment with indoximod post sipuleucel-T therapy is well tolerated and led to a significant improvement in radiographic and clinical progression. Augmentation of immune response to PA2024 by ELISPOT or ELISA might not be right biomarker for augmented response assessment while studying inhibition of IDO pathway. Clinical trial information: NCT01560923.
La rabia de los murciélagos es un problema de salud publica en Europa
Authors: Mirjana Stantic-Pavlinic
Journal: Eurosurveillance (2005)

La rabia debida a dos genotipos de lyssavirus diferentes e independientes – los lyssavirus de murcielagos europeos (EBLV) tipo 1 y tipo 2 – esta presente en numerosos paises de Europa. La infeccion se encuentra generalmente en los murcielagos que son el principal reservorio primario de los virus, pero se han descrito infecciones en otras especies: martas, ovejas y hombres. Excepto por dos casos humanos, esas infecciones fueron todas debidas a EBLV-1. No se notifico ningun caso debido a EBLV-2 en animales terrestres. 
La enfermedad es fatal en humanos y fue descrita en Europa tras una mordedura por un murcielago. En este articulo estudiamos los casos documentados de rabia por EBLV en Europa en hombres y en murcielagos, y las recomendaciones sobre la prevencion y el tratamiento de la rabia en el hombre. La vacunacion antirrabica antes de una exposicion y el tratamiento post-exposicion se recomiendan para las personas expuestas profesionalmente. Ciertos paises de Europa ya adoptaron recomendaciones segun protocolos especificos. Se recomienda tambien profilaxis para los viajeros internacionales despues una mordedura por un murcielago. Se esta promoviendo la investigacion sobre la rabia trasmitida por murcielagos en Europa. Los murcielagos forman parte de las especies protegidas en Europa.
Therapy related-chronic myelomonocytic leukemia (CMML): Molecular, cytogenetic, and clinical distinctions from<i>de novo</i>CMML
Authors: Mrinal M. Patnaik, Rangit Vallapureddy, Fevzi F. Yalniz, Curtis A. Hanson, Rhett P. Ketterling, Terra L. Lasho, Christy Finke, Aref Al‐Kali, Naseema Gangat, Ayalew Tefferi
Journal: American Journal of Hematology (2017)

Therapy related myeloid neoplasms (t-MN) including therapy related myelodysplastic syndromes (t-MDS) and acute myeloid leukemia (t-AML) are associated with aggressive disease biologies and poor outcomes. In this large (n = 497) and informative (inclusive of molecular and cytogenetic information) chronic myelomonocytic leukemia (CMML) patient cohort, we demonstrate key biological insights and an independent prognostic impact for t-CMML. T-CMML was diagnosed in 9% of patients and occurred approximately 7 years after exposure to prior chemotherapy and/or radiation therapy. In comparison to de novo CMML, t-CMML patients had higher LDH levels, higher frequency of karyotypic abnormalities and had higher risk cytogenetic stratification. There were no differences in the distribution of gene mutations and unlike t-MDS/AML, balanced chromosomal translocations, abnormalities of chromosome 11q23 (1%) and Tp53 mutations (<2%) were uncommon. Molecularly integrated CMML prognostic models were not effective in risk stratifying t-CMML patients and responses to hypomethylating agents were dismal with no complete responses. Median overall (OS) and leukemia free survival (LFS) was shorter for t-CMML in comparison to d-CMML (Median OS 10.9 vs 26 months and median LFS 50 vs 127 months) and t-CMML independently and adversely impacted OS (P = .0001 HR 2.1 95% CI 1.4-3.0). This prognostic impact was retained in the context of the Mayo Molecular Model (P = .001, HR 2.4, 95% CI 1.5-3.7) and the GFM prognostic model (P < .0001, HR 2.15, 95% CI 1.5-3.7). In summary, we highlight the unique genetics and independent prognostic impact of t-CMML, warranting its inclusion as a separate entity in the classification schema for both CMML and t-MN.
Vigilância da exposição profissional aos agentes patogénicos transmitidos pelo sangue em profissionais de saúde: programa nacional italiano
Authors: G Ippolito, V Puro, N Petrosillo, G De Carli
Journal: Eurosurveillance (1999)

Os profissionais de saude (PS) enfrentam um grave risco de adquirirem infeccoes transmitidas pelo sangue, em particular o virus da hepatite B (VHB), o virus da hepatite C (VHC) e o virus da imunodeficiencia humana (VIH); todos eles estao associados a uma morbilidade e mortalidade significativas. Em 1986, o centro coordenador do estudo Italiano sobre o risco profissional de infeccao pelo VIH (Studio Italiano Rischio Occupazionale da VIH, SIROH) iniciou um estudo prospectivo multicentrico destinado a calcular o risco de transmissao do VIH e outros agentes patogenicos transmitidos pelo sangue aos PS apos uma exposicao profissional ao sangue e outros materiais corporais, bem como para identificar dispositivos, procedimentos e profissoes de alto risco nos estabelecimentos de saude. Desde 1990 que o centro coordenador organiza o registo Italiano da profilaxia anti-retroviral apos a exposicao, de forma a monitorizar a utilizacao e a toxicidade a curto prazo da zidovudina (ZDV) e, desde 1995, da profilaxia de combinacao antiretroviral. Este artigo descreve o SIROH e apresenta resultados que ilustram o seu potencial.
Vigilância da doença de Lyme na Alemanha, 2002-2003
Authors: W H Mehnert, G Krause
Journal: Eurosurveillance (2005)

A doenca de Lyme ou borreliose de Lyme e uma infeccao potencialmente grave, frequente na Alemanha, mas existem poucos dados sobre a sua incidencia, distribuicao e suas manifestacoes clinicas. Na Alemanha esta doenca nao e de declaracao obrigatoria, mas seis dos 16 estados alemaos - Berlin, Brandenburg, Mecklenburg-Vorpommern, Sachsen, Sachsen-Anhalt e Thuringen, incluiram-na no seu sistema de notificacao obrigatoria. Os esforcos feitos nestes estados para monitorizar os casos confirmados a traves da declaracao, constituem uma contribuicao importante para compreender a epidemiologia desta doenca na Alemanha. O relatorio seguinte resume a analise dos casos de doenca de Lyme declarados ao Instituto Robert-Koch em 2002-2003. 
A incidencia media da doenca de Lyme nos seis estados do leste da Alemanha aumentou de 31%, passando de 17,8/100.000 em 2002 a 23,3/100.000 em 2003. A distribuicao por grupos de idade dos pacientes mostrou dois picos de indidencia: em criancas entre 5 e9 anos, e em pessoas idosas, entre 60 e 64 anos em 2002 e entre 65 e 69 em 2003. Nesses dois anos, 55% dos pacientes eram mulheres. Quase 86% dos casos foram declarados entre os meses de maio e outubro. Um eritema migratorio afectou 2 697 pacientes (89,3%) em 2002 e 3.442 (86,7%) em 2003. 
Quando uma doenca se transmite por um vetor, como a doenca de Lyme, o risco de infeccao depende do grau e da duracao do contacto entre os homens e as carracas infectadas por Borrelia burgdorferi. Dado que as carracas infectadas estao provavelmente presentes sobre todo o territorio da Alemanha, a situacao dos outros dez estados alemaos deve ser semelhante a descrita em nosso estudo.
反磁性化学交換飽和移動(diaCEST)は脳卒中のラットモデルにおける細胞外マトリックスヒドロゲル注入の磁気共鳴画像を提供する【Powered by NICT】
Authors: Jin Tao, J Nicholls Francesca, R Crum William, Ghuman Harmanvir, F Badylak Stephen, Modo Michel
Journal: Biomaterials (2017)
MetaGen: reference-free learning with multiple metagenomic samples
Authors: Xin Xing, Jun S. Liu, Wenxuan Zhong
Journal: Genome biology (2017)

A major goal of metagenomics is to identify and study the entire collection of microbial species in a set of targeted samples. We describe a statistical metagenomic algorithm that simultaneously identifies microbial species and estimates their abundances without using reference genomes. As a trade-off, we require multiple metagenomic samples, usually ≥10 samples, to get highly accurate binning results. Compared to reference-free methods based primarily on k-mer distributions or coverage information, the proposed approach achieves a higher species binning accuracy and is particularly powerful when sequencing coverage is low. We demonstrated the performance of this new method through both simulation and real metagenomic studies. The MetaGen software is available at https://github.com/BioAlgs/MetaGen .
Efficacy of a movement control injury prevention programme in adult men’s community rugby union: a cluster randomised controlled trial
Authors: Matthew J Attwood, Simon P Roberts, Grant Trewartha, Mike E England, Keith A Stokes
Journal: British Journal of Sports Medicine (2017)

Exercise programmes aimed at reducing injury have been shown to be efficacious for some non-collision sports, but evidence in adult men's collision sports such as rugby union is lacking.To evaluate the efficacy of a movement control injury prevention exercise programme for reducing match injuries in adult men's community rugby union players.856 clubs were invited to participate in this prospective cluster randomised (single-blind) controlled trial where clubs were the unit of randomisation. 81 volunteered and were randomly assigned (intervention/control). A 42-week exercise programme was followed throughout the season. The control programme reflected 'normal practice' exercises, whereas the intervention focused on proprioception, balance, cutting, landing and resistance exercises.Outcome measures were match injury incidence and burden for: (1) all ≥8 days time-loss injuries and (2) targeted (lower limb, shoulder, head and neck, excluding fractures and lacerations) ≥8 days time-loss injuries.Poisson regression identified no clear effects on overall injury outcomes. A likely beneficial difference in targeted injury incidence (rate ratio (RR), 90% CI=0.6, 0.4 to 1.0) was identified, with a 40% reduction in lower-limb incidence (RR, 90% CI=0.6, 0.4 to 1.0) and a 60% reduction in concussion incidence (RR, 90% CI=0.4, 0.2 to 0.7) in the intervention group. Comparison between arms for clubs with highest compliance (≥median compliance) demonstrated very likely beneficial 60% reductions in targeted injury incidence (RR, 90% CI=0.4, 0.2 to 0.8) and targeted injury burden (RR, 90% CI=0.4, 0.2 to 0.7).The movement control injury prevention programme resulted in likely beneficial reductions in lower-limb injuries and concussion. Higher intervention compliance was associated with reduced targeted injury incidence and burden.
A randomized, double-blind, placebo-controlled multicenter phase 3 trial of niraparib maintenance treatment in patients with advanced ovarian cancer following frontline chemotherapy
Authors: A. Gonzalez Martin, L.A. Rojas, P.S. Braly, J. Barter, D.M. O'Malley, A.M. Oza, A.F. Haggerty, C. Vulsteke, D.M. Provencher, W. Graybill, Y. Li, I.A. Malinowska, M.R. Mirza, I. Vergote, B. Pothuri, B.J. Monk
Journal: Annals of Oncology (2017)