Every Cloud Has a Silver Lining: Overdose-Death Donors in Organ Transplantation
Authors: Camille Nelson Kotton
Journal: Annals of Internal Medicine (2018)

Editorials15 May 2018Every Cloud Has a Silver Lining: Overdose-Death Donors in Organ TransplantationCamille Nelson Kotton, MDCamille Nelson Kotton, MDMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (C.N.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-0720 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Nearly 115 000 candidates currently await organ transplantation in the United States (mostly kidneys [81%] and livers [12%]) (1). Because of the profound organ shortage, many candidates awaiting transplant experience significant morbidity and mortality each year. In this issue, Durand and colleagues (2) review the use of overdose-death donor (ODD) organ transplants involving 138 565 deceased donors and 337 934 solid organ transplant recipients from 2000 to 2017. The study used the Scientific Registry of Transplant Recipients, which includes U.S. national data collected by the Organ Procurement and Transplantation Network (OPTN). The authors found that ODD transplants increased 24-fold, from 149 in 2000 ...References1. United Network for Organ Sharing. Waiting List Candidates by Organ Type - All Patient States. Richmond, VA: United Network for Organ Sharing; 2018. Accessed at https://unos.org/data/transplant-trends/waiting-list-candidates-by-organ-type on 17 March 2018. Google Scholar2. Durand CM, Bowring MG, Thomas AG, Kucirka LM, Massie AB, Cameron A, et al. The drug overdose epidemic and deceased-donor transplantation in the United States. A national registry study. Ann Intern Med. 2018;168:702-11. doi:10.7326/M17-2451 LinkGoogle Scholar3. Durand CM, Bowring MG, Brown DM, Chattergoon MA, Massaccesi G, Bair N, et al. Direct-acting antiviral prophylaxis in kidney transplantation from hepatitis C virus-infected donors to noninfected recipients: an open-label nonrandomized trial. Ann Intern Med. 2018. [PMID: 29507971] doi:10.7326/M17-2871 LinkGoogle Scholar4. Goldberg DS, Abt PL, Blumberg EA, Van Deerlin VM, Levine M, Reddy KR, et al. Trial of transplantation of HCV-infected kidneys into uninfected recipients [Letter]. N Engl J Med. 2017;376:2394-5. [PMID: 28459186] doi:10.1056/NEJMc1705221 CrossrefMedlineGoogle Scholar5. Muller E, Barday Z. HIV-positive kidney donor selection for HIV-positive transplant recipients. J Am Soc Nephrol. 2018. [PMID: 29330339] doi:10.1681/ASN.2017080853 CrossrefMedlineGoogle Scholar6. Bowring MG, Holscher CM, Zhou S, Massie AB, Garonzik-Wang J, Kucirka LM, et al. Turn down for what? Patient outcomes associated with declining increased infectious risk kidneys. Am J Transplant. 2018;18:617-24. [PMID: 29116674] doi:10.1111/ajt.14577 CrossrefMedlineGoogle Scholar7. OPTN/SRTR 2016 annual data report: introduction. Am J Transplant. 2018;18 Suppl 1:10-7. [PMID: 29292601] doi:10.1111/ajt.14556 CrossrefMedlineGoogle Scholar8. Kim WR, Lake JR, Smith JM, Schladt DP, Skeans MA, Harper AM, et al. OPTN/SRTR 2016 annual data report: liver. Am J Transplant. 2018;18 Suppl 1:172-253. [PMID: 29292603] doi:10.1111/ajt.14559 CrossrefMedlineGoogle Scholar9. Rahnemai-Azar AA, Perkins JD, Leca N, Blosser CD, Johnson CK, Morrison SD, et al. Unintended consequences in use of increased risk donor kidneys in the new kidney allocation era. Transplant Proc. 2018;50:14-9. [PMID: 29407297] doi:10.1016/j.transproceed.2017.11.025 CrossrefMedlineGoogle Scholar10. Ison MG, Rana MM, Brizendine KD, Chimienti S, Le J, Kfoury R, et al. Screening recipients of increased risk donor organs: a multicenter retrospective study. Transpl Infect Dis. 2018. [PMID: 29512233] doi:10.1111/tid.12862 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (C.N.K.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-0720.Corresponding Author: Camille Nelson Kotton, MD, Clinical Director, Transplant and Immunocompromised Host Infectious Diseases, Infectious Diseases Division, Massachusetts General Hospital, 55 Fruit Street, Cox 5, Boston, MA 02114; e-mail, [email protected]org.This article was published at Annals.org on 17 April 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Drug Overdose Epidemic and Deceased-Donor Transplantation in the United States Christine M. Durand , Mary G. Bowring , Alvin G. Thomas , Lauren M. Kucirka , Allan B. Massie , Andrew Cameron , Niraj M. Desai , Mark Sulkowski , and Dorry L. Segev Metrics Cited byVariation in opioid prescribing patterns after abdominal transplant surgeryUse of HCV‐infected organs in solid organ transplantation: An ethical challenge but plausible optionCan we mitigate the effects of simultaneous liver-kidney transplantation through increased utilization of HCV-positive donors? 15 May 2018Volume 168, Issue 10Page: 739-740KeywordsAddictionDecision makingDisclosureHIV infectionsInfectious diseasesKidneysLiver transplantationOrgan transplantationRenal analysisTransplantation ePublished: 17 April 2018 Issue Published: 15 May 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...