tbuckley/cabot-search huggingface dataset:
TCT-288 Safety and Clinical Performance of the Drug Eluting Absorbable Metal Scaffold in the Treatment of Subjects with de Novo Lesions in Native Coronary Arteries at 24-month follow-up-BIOSOLVE-II
Authors: Michael Haude, Hüseyin Ince, Alexandre Abizaid, Ralph Toelg, Pedro A. Lemos, Clemens von Birgelen, Evald Christiansen, William Wijns, Franz-Josef Neumann, Eric Eeckhout, Javier Escaned, Ron Waksman, Hector Garcia-Garcia
Journal: Journal of the American College of Cardiology (2017)
Skeletal Muscle Regenerative Potential of Human MuStem Cells following Transplantation into Injured Mice Muscle
Authors: Judith Lorant, Charlotte Saury, Cindy Schleder, Florence Robriquet, Blandine Lieubeau, Elisa Négroni, Isabelle Leroux, Lucie Chabrand, Sabrina Viau, Candice Babarit, Mireille Ledevin, Laurence Dubreil, Antoine Hamel, Armelle Magot, Chantal Thorin, Laëtitia Guevel, Bruno Delorme, Yann Péréon, Gillian Butler-Browne, Vincent Mouly, Karl Rouger
Journal: Molecular Therapy (2017)

After intra-arterial delivery in the dystrophic dog, allogeneic muscle-derived stem cells, termed MuStem cells, contribute to long-term stabilization of the clinical status and preservation of the muscle regenerative process. However, it remains unknown whether the human counterpart could be identified, considering recent demonstrations of divergent features between species for several somatic stem cells. Here, we report that MuStem cells reside in human skeletal muscle and display a long-term ability to proliferate, allowing generation of a clinically relevant amount of cells. Cultured human MuStem (hMuStem) cells do not express hematopoietic, endothelial, or myo-endothelial cell markers and reproducibly correspond to a population of early myogenic-committed progenitors with a perivascular/mesenchymal phenotypic signature, revealing a blood vessel wall origin. Importantly, they exhibit both myogenesis in vitro and skeletal muscle regeneration after intramuscular delivery into immunodeficient host mice. Together, our findings provide new insights supporting the notion that hMuStem cells could represent an interesting therapeutic candidate for dystrophic patients. After intra-arterial delivery in the dystrophic dog, allogeneic muscle-derived stem cells, termed MuStem cells, contribute to long-term stabilization of the clinical status and preservation of the muscle regenerative process. However, it remains unknown whether the human counterpart could be identified, considering recent demonstrations of divergent features between species for several somatic stem cells. Here, we report that MuStem cells reside in human skeletal muscle and display a long-term ability to proliferate, allowing generation of a clinically relevant amount of cells. Cultured human MuStem (hMuStem) cells do not express hematopoietic, endothelial, or myo-endothelial cell markers and reproducibly correspond to a population of early myogenic-committed progenitors with a perivascular/mesenchymal phenotypic signature, revealing a blood vessel wall origin. Importantly, they exhibit both myogenesis in vitro and skeletal muscle regeneration after intramuscular delivery into immunodeficient host mice. Together, our findings provide new insights supporting the notion that hMuStem cells could represent an interesting therapeutic candidate for dystrophic patients.
Effect of Oral Administration of Aniline and &lt;italic&gt;p&lt;/italic&gt;-Aminodimethylaniline on the Growth of the Rat&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Julius White, Jesse E. Edwards
Journal: JNCI Journal of the National Cancer Institute (1942)

Effect of Oral Administration of Aniline and p-Aminodimethylaniline on the Growth of the Rat Get access Julius White, Julius White senior biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse E. Edwards Jesse E. Edwards research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 6, June 1942, Pages 531–533, https://doi.org/10.1093/jnci/2.6.531 Published: 01 June 1942
TCT-556 Exposure to Glucocorticoids Prior to Transcatheter Aortic Valve Replacement is Associated with Reduced Incidence of High-Degree AV block and Pacemaker
Authors: Brett Oestreich, Selcuk Adabag, Rosemary Kelly, Gregory Helmer, Ganesh Raveendran, Demetris Yannopoulos, Timinder Biring, Santiago Garcia
Journal: Journal of the American College of Cardiology (2017)
Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota
Authors: Rui M Ferreira, Joana Pereira-Marques, Ines Pinto-Ribeiro, Jose L Costa, Fatima Carneiro, Jose C Machado, Ceu Figueiredo
Journal: Gut (2017)

Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our aim was to evaluate the composition of the gastric microbiota in chronic gastritis and in gastric carcinoma.The gastric microbiota was retrospectively investigated in 54 patients with gastric carcinoma and 81 patients with chronic gastritis by 16S rRNA gene profiling, using next-generation sequencing. Differences in microbial composition of the two patient groups were assessed using linear discriminant analysis effect size. Associations between the most relevant taxa and clinical diagnosis were validated by real-time quantitative PCR. Predictive functional profiling of microbial communities was obtained with PICRUSt.The gastric carcinoma microbiota was characterised by reduced microbial diversity, by decreased abundance of Helicobacter and by the enrichment of other bacterial genera, mostly represented by intestinal commensals. The combination of these taxa into a microbial dysbiosis index revealed that dysbiosis has excellent capacity to discriminate between gastritis and gastric carcinoma. Analysis of the functional features of the microbiota was compatible with the presence of a nitrosating microbial community in carcinoma. The major observations were confirmed in validation cohorts from different geographic origins.Detailed analysis of the gastric microbiota revealed for the first time that patients with gastric carcinoma exhibit a dysbiotic microbial community with genotoxic potential, which is distinct from that of patients with chronic gastritis.
TCT-130 Comparison of Bioresorbable Scaffold Measurements between Intravascular Ultrasound and Quantitative Coronary Angiography in the ABSORB Japan Trial
Authors: Kozo Okada, Yasuhiro Honda, Hideki Kitahara, M. Brooke Hollak, Paul G. Yock, Jeffrey J. Popma, Hajime Kusano, Wai-Fung Cheong, Krishna Sudhir, Peter J. Fitzgerald, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2017)
Is there a role for empiric radiation without a confirmatory biopsy for a subset of patients with radiographically-malignant primary brain tumors?: An analysis of short-term morbidity and mortality.
Authors: Stuart Burri, Renee P Kelly, Roshan Sudhir Prabhu, Scott D Wait, Peggy O Boltes, Ashley Love Sumrall, Daniel Ernest Haggstrom, Alexis Betancourt, James Thomas Symanowski, Robert W. Fraser, Anthony L. Asher
Journal: Journal of Clinical Oncology (2015)

e13001 Background: In patients with MRI brain scans consistent with unresectable glioma, the current standard of care is to confirm with a stereotactic biopsy. However, stereotactic biopsy is not without clinical risk. Methods: A series of 181 patients who underwent stereotactic biopsy for malignant brain lesions between 2006 – 2014 was reviewed with particular attention to risk of near-term neurologic decline and death. Results: In the evaluable set of 158 patients, the median age was 63. 77.2% of the patients had Grade 4 tumors, while 20.9% had a pre-biopsy performance status (PS) of ECOG 3-4. The overall risk of death within 30 days of biopsy was 13.9%. Neurological decline directly attributable to the biopsy occurred in 19.7% of patients, while 5.3% experienced both neurologic decline and death within 30 days. The rate of death within 30 days of stereotactic biopsy for grade 2/3 tumors was 5.6%, grade 4 tumors was 16.4% and patients > 65 was 18.2%. The 30-day rate of death and neurologic decline attributable to biopsy in patients with pre-treatment ECOG 3-4 was 21.2% (vs. 12% ECOG 0-2, p = 0.067) and 35.7% (vs. 15.4% ECOG 0-2, p = 0.064), respectively. Patients who were ECOG 3-4 and age > 65 had a 30-day mortality rate of 23.1%. Conclusions: There is a meaningful risk of death within 30 days and neurologic decline related to stereotactic biopsy in patients with radiographic unresectable malignant glioma, particularly in those with diminished PS. Patients who are not likely to be candidates for chemotherapy, particularly those with an ECOG PS of 3-4, are more likely to be harmed by biopsy. Empiric radiation should be considered in high-risk patients saving both the financial cost and potential morbidity and mortality from the biopsy which is unlikely to alter the care plan.
TCT-224 Gastrointestinal Bleed Pre-Transcatheter Aortic Valve Replacement: An Independent Predictor of Mortality
Authors: Rafath Ullah, Mubeen Khan Mohammed Abdul, Maharaj Singh, Puneet Menaria, Amanda Kirby, Suhail Q. Allaqaband, Daniel P. O'Hair, Tanvir Bajwa, Tonga Nfor
Journal: Journal of the American College of Cardiology (2017)
TCT-664 Improved early risk stratification of patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention using a combination of serum ST2 and NT-proBNP
Authors: Pyung Chun Oh, Jongwook Yu, Minsu Kim, Jeonggeun Moon, Yae Min Park, Woong Chol Kang
Journal: Journal of the American College of Cardiology (2017)
TCT-685 Thermal heterogeneity of carotid arteries as a novel biomarker in patients undergoing coronary angiography
Authors: George Tzanis, Maria Bonou, Giorgos Benetos, Smaragda Biliou, Stavros Liatis, Glafkos Kelepeshis, Elias Sanidas, George Anastasiadis, Konstantinos Toutouzas, John Barbetseas
Journal: Journal of the American College of Cardiology (2017)
Linda Carol New
Authors: David Ward, Justin Bendig
Journal: BMJ (2017)

Just after starting her A levels, and intending to study languages or geography at university, Linda Carol New had appendicitis. As a result of her experience in hospital she changed direction and decided to become a doctor. At medical school, she achieved a first and won several prizes. As part of her intercalated BSc, Linda did a research module in the microbiology department, studying Toxoplasma , and this set her on her …
Role of AP-2α and MAPK7 in the regulation of autocrine TGF-β/miR-200b signals to maintain epithelial-mesenchymal transition in cholangiocarcinoma
Authors: Dawei Zhang, Haiyan Li, Xiaofeng Jiang, Liangqi Cao, Zilong Wen, Xuewei Yang, Ping Xue
Journal: Journal of Hematology & Oncology (2017)

Cholangiocarcinoma (CCA) is characterized by early lymphatic, metastasis, and low survival rate. Epithelial-mesenchymal transition (EMT) is able to induce tumor metastasis. Although the TGF-β/miR-200 signals promote EMT in various types of cancer, the regulatory mechanism in CCA is still unclear. Expression of miR-200b, TGF-β, and EMT markers were measured in tumor samples and cell lines by qRT-PCR and western blot. CCK8 assay was performed to measure the cell viability. Transwell assay was used to evaluate migration and invasion. The target genes of miR-200b and transcription factor of TGF-β were analyzed using dual-luciferase reporter system. We have demonstrated that CCA exhibited remarkable EMT phenotype and miR-200b was reduced in CCA patients (n = 20) and negatively correlated to TGF-β. Moreover, two CCA cells, HCCC, and RBE, with epithelial appearances treated with TGF-β, showed fibroblastic-like cell morphology with downregulated miR-200b expression. Forced expression of miR-200b abrogated TGF-β-induced EMT initiation, with decreased cell proliferation, migration, and invasion in vitro. Also, TFAP2A (encode AP-2α) and MAPK7 were found to be targeted by miR-200b to downregulate EMT and AP-2α inhibited miR-200b by directly promoting transcription of TGFB1. Overexpression of MAPK7 significantly reversed miR-200b-induced inhibition of EMT, migration, and proliferation by increasing the expression of TGF-β, cyclin D1, and Cdk2. Further, the administration of miR-200b induced a remarkably tumor regression in vivo and reduced the effect of TGF-β-related EMT in AP-2α and MAPK7-dependent manner. Our study highlights that miR-200b-based gene therapy is effective in the treatment of CCA.
Evidence for Kaposi Sarcoma Originating from Mesenchymal Stem Cell through KSHV-induced Mesenchymal-to-Endothelial Transition
Authors: Yuqing Li, Canrong Zhong, Dawei Liu, Wenjing Yu, Weikang Chen, Yan Wang, Songtao Shi, Yan Yuan
Journal: Cancer Research (2017)

Abstract The major transmission route for Kaposi sarcoma–associated herpesvirus (KSHV) infection is the oral cavity through saliva. Kaposi sarcoma (KS) frequently occurs in the oral cavity in HIV-positive individuals and is often the first presenting sign of AIDS. However, the oral target cells for KSHV infection and the cellular origin of Kaposi sarcoma remain unknown. Here we present clinical and experimental evidences that Kaposi sarcoma spindle cells may originate from virally modified oral mesenchymal stem cells (MSC). AIDS-KS spindle cells expressed neuroectodermal stem cell marker (Nestin) and oral MSC marker CD29, suggesting an oral/craniofacial MSC lineage of AIDS-associated Kaposi sarcoma. Furthermore, oral MSCs were highly susceptible to KSHV infection, and infection promoted multilineage differentiation and mesenchymal-to-endothelial transition (MEndT). KSHV infection of oral MSCs resulted in expression of a large number of cytokines, a characteristic of Kaposi sarcoma, and upregulation of Kaposi sarcoma signature and MEndT-associated genes. These results suggest that Kaposi sarcoma may originate from pluripotent MSC and KSHV infection transforms MSC to Kaposi sarcoma–like cells through MEndT. Significance: These findings indicate that Kaposi sarcomas, which arise frequently in AIDS patients, originate from neural crest-derived mesenchymal stem cells, with possible implications for improving the clnical treatment of this malignancy. Cancer Res; 78(1); 230–45. ©2017 AACR.
SARM en las residencias asistidas de los Países Bajos entre 1989 y 1998: ¿un reservorio en expansión?
Authors: W Goettsch, E Geubbels, W J B Wannet, M G R Hendrix, J H T Wagenvoort, A J de Neeling
Journal: Eurosurveillance (2000)

La prevalencia de aislamientos de Staphylococcus aureus resistentes a la meticilina (SARM) en residencias asistidas holandesas durante 1998 supero a la registrada entre 1989 y 1997. La mayor prevalencia de SARM podria dar lugar a una colonizacion fuera de estos hospitales. Un estudio de la prevalencia de SARM en estos establecimientos, que comenzara a mediados del ano 2000, estudiara su papel como reservorios de infecciones nosocomiales causadas por SARM.
Exosomes from Patients with Sickle Cell Disease and History of Acute Chest Syndrome Alter Endothelial Integrity In Vitro
Authors: Gabrielle Lapping-Carr, Abdelnaby Khalyfa, Wendy Darlington, Elizabeth Joyce, Joanna Gemel, Radhika Peddinti, Eric Beyer, John M Cunningham, David Gozal
Journal: Blood (2016)
Abstract 12905: Initial Surgery Versus Conservative Management for Elderly Patients With Symptomatic Severe Mitral Regurgitation
Authors: Ran Heo, Duk-Hyun Kang, Sahmin Lee, Dae-Hee Kim, Jong-Min Song, Kee-Joon Choi, Jae-Kwan Song, Jae-Won Lee, Joo-Hee Zo
Journal: Circulation (2016)

Background: The benefit of surgical correction of severe mitral regurgitation (MR) may not be greater than operative risk in elderly patients without significant symptoms. This study sought to compare long-term survival between initial surgery and conservative management in elderly patients (≥ 70 years of age) with mild symptoms and severe MR. Methods: From 1996 to 2014, we prospectively evaluated 157 consecutive elderly patients (75 men, 74 ± 4 years of age) with severe degenerative MR who have dyspnea of NYHA functional class II. Mitral valve (MV) surgery was performed on 79 patients (OP group) within 3 months of the initial evaluation and the conservative strategy was chosen for 78 patients (conservative group). Follow-up data were obtained until April 2016, and the primary end-point was occurrence of cardiac death and the secondary end-point was death from any cause. Methods: In the OP group, operative mortality was 1.3%, and MV repair and replacement were performed in 64 (81%) and 15 (19%) patients, respectively, and 8 (10%) patients underwent late MV surgery in the conservative group. The risk of cardiac mortality was significantly lower in the OP group (HR 0.32; 95% CI, 0.14 to 0.75; P = 0.008), and the estimated actuarial 10-year cardiac mortality rates were 11 ± 5% in the OP group and 45 ± 8% in the conservative group (Figure). The risk of all-cause mortality was also significantly lower in the OP group (HR 0.39; 95% CI, 0.21 to 0.74; P = 0.004). Conservative strategy was independently associated with cardiac mortality (HR 0.34; 95% CI, 0.14 to 0.81; P = 0.016) and overall mortality (HR 0.41; 95% CI, 0.21 to 0.79; P = 0.008) in the Cox proportional hazards analysis adjusted for age and STS score. Conclusions: Compared with conservative management, initial surgical strategy for severe MR is associated with significant long-term reductions of overall mortality and cardiac mortality in elderly patients without significant symptoms.
Management of Stage I Squamous Cell Carcinoma of the Anal Canal
Authors: Christy Y. Chai, Hop S. Tran Cao, Samir Awad, Nader N. Massarweh
Journal: JAMA Surgery (2017)

<h3>Importance</h3> The incidence of squamous cell carcinoma of the anal canal (SCCAC) is increasing. Although standard management of SCCAC includes the use of concurrent chemotherapy and radiotherapy (chemoradiotherapy), data are lacking on potentially less morbid, alternative management strategies, such as local excision, among patients with node-negative T1 disease. <h3>Objectives</h3> To examine the use of local excision among patients with T1 SCCAC and to compare overall survival relative to those who received standard treatment with chemoradiotherapy. <h3>Design, Setting, and Participants</h3> This retrospective cohort study assessed 2243 patients in the National Cancer Database (2004-2012) between 18 and 80 years of age with T1N0M0 SCCAC. The association between the type of treatment received and overall risk of death was evaluated using multivariable Cox proportional hazards regression models. Data analysis was performed from June 29, 2016, to April 17, 2017. <h3>Main Outcomes and Measures</h3> Overall survival. <h3>Results</h3> Among 2243 patients with T1N0 SCCAC, 503 (22.4%) were treated with local excision alone (mean [SD] age, 54.5 [12.1] years; 240 [47.7%] male; 419 [83.3%] white) and 1740 with chemoradiotherapy (mean [SD] age, 57.0 [10.6] years; 562 [32.3%] male; 1547 [88.9%] white). Among those treated with chemoradiotherapy, 12 patients underwent a subsequent abdominoperineal resection. There was a statistically significant increase in the use of local excision during the study period (34 [17.3%] in 2004 to 68 [30.8%] in 2012; trend test,<i>P</i> &lt; .001). This increase in use was observed among patients with primary tumors that measured 1 cm or smaller and greater than 1 cm to 2 cm or smaller (trend test,<i>P</i> &lt; .001 for both). Overall survival at 5 years was not significantly different for the 2 management strategies (85.3% in the local excision cohort and 86.8% in the chemoradiotherapy cohort; log-rank test,<i>P</i> = .93). Overall risk of death was not significantly different for local excision alone relative to that for treatment with chemoradiotherapy (hazard ratio, 1.06; 95% CI, 0.78-1.44). These findings were robust when stratified by tumor size and when patients who underwent abdominoperineal resection after chemoradiotherapy were excluded. <h3>Conclusions and Relevance</h3> The use of local excision alone for the management of T1N0 SCCAC has significantly increased over time, with no clear decrement in overall survival. Because local excision may represent a lower-cost, less morbid treatment option for select patients with SCCAC, future studies are needed to better delineate its role and efficacy relative to the current standard of chemoradiotherapy.
Aparecimento de Salmonela typhimurium DT 104 multirresistente na República Checa
Authors: R Karpíšková, D Benes, D Dedicova
Journal: Eurosurveillance (1999)

A Republica Checa e um pais da Europa Central com uma populacao de cerca de 10 milhoes de habitantes. As salmoneloses sao as doencas infecciosas intestinais mais notificadas. Ate 1989, eram notificados cerca de 10 000 casos, em cada ano, com um numero identico de isolamentos de Salmonela enteritidis e S. typhimurium. Desde 1989, os casos de salmonelose humana tem subido rapidamente. De 1993 a 1997 foram notificados, em cada ano, de 39 862 a 54 554 casos, correspondendo a uma incidencia de 386 a 518 casos per 100 000 habitantes, registando-se um pico em 1995. A S. enteritidis foi responsavel por 95% dos casos notificados e a S. typhimurium por 3%.
Triquinosis humana por Trichinella britovi en el sur de Francia relacionada con el consumo de carne de jabalí congelada
Authors: M Gari-Toussaint, N Tieulié, J L Baldin, J Dupouy-Camet, P Delaunay, J G Fuzibet, Y Le Fichoux, E Pozio, P Marty
Journal: Eurosurveillance (2005)

Seis pacientes fueron infectados por Trichinella britovi en el sur de Francia despues de haber comido carne de jabali congelada a -35°C durante siete dias. El examen microscopico de una muestra de musculo congelado revelo la presencia de larvas encapsuladas de Trichinella, identificadas como T. britovi. Los consumidores de carne de jabali deben seguir normas profilacticas individuales, como son el cocinado eficaz de la carne (al menos, 65°C en el centro de la pieza durante un minuto como minimo) segun las recomendaciones de la Comision Internacional de la Triquinosis, o al menos cuatro semanas de congelacion a -20°C.
Brotes de parvovirus B19 en tres escuelas portuguesas
Authors: G Gonçalves, A M Correia, P Palminha, H Rebelo de Andrade, A Alves
Journal: Eurosurveillance (2005)

El siguiente articulo describe el estudio del brote de exantemas agudos en ninos de tres escuelas de la ciudad de Braga, Portugal. Los analisis de laboratorio, realizados en cinco casos, mostraron que la enfermedad no estaba asociada con el virus del sarampion o de la rubeola, y confirmaron la infeccion por el parvovirus B19. Fueron infectados 41 ninos: 12 en la guarderia, 17 en la escuela secundaria y 12 en la escuela primaria. Solo fue afectado un empleado de la guarderia. Entre los contactos familiares se identificaron ocho casos; dos eran hermanos, uno en la guarderia y el otro en la escuela secundaria donde el brote fue posterior al de la guarderia. Los valores estimados de la tasa de reproduccion basica R0 eran muy bajos y es probable que existieran casos infecciosos asintomaticos. Las autoridades sanitarias locales publicaron informacion por escrito y se reunieron con los miembros del personal y los padres. Se informo a los establecimientos de atencion primaria asi como al departamento de obstetricia del hospital local. En Portugal el objetivo de la eliminacion del sarampion esta cerca, como en toda Europa, con coberturas vacunales muy altas, asi es posible que una proporcion importante de exantemas no vesiculares sean debidos a infecciones por B19. Eso deberia tenerse en cuenta para llevar a cabo y manejar las actividades de vigilancia, en el contexto de los programas de eliminacion del sarampion y de la rubeola.