tbuckley/cabot-search huggingface dataset:
Considering Spastic Paraplegia Type 7 and Adult-Onset Alexander Disease
Authors: Adolfo Ramirez-Zamora, Michael S. Okun
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease
Authors: Alfonso Tan-Garcia, Lu-En Wai, Dahai Zheng, Erica Ceccarello, Juandy Jo, Nasirah Banu, Atefeh Khakpoor, Adeline Chia, Christine Y.L. Tham, Anthony T. Tan, Michelle Hong, Choong Tat Keng, Laura Rivino, Kai Chah Tan, Kang Hoe Lee, Seng Gee Lim, Evan W. Newell, Norman Pavelka, Jinmiao Chen, Florent Ginhoux, Qingfeng Chen, Antonio Bertoletti, Charles-Antoine Dutertre
Journal: Journal of Hepatology (2017)
Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol
Authors: Alexey Ostroumov, John A. Dani
Journal: The Annual Review of Pharmacology and Toxicology (2017)

Stress and tobacco smoking are risk factors for alcoholism, but the underlying neural mechanisms are not well understood. Although stress, nicotine, and alcohol have broad, individual effects in the brain, some of their actions converge onto the same mechanisms and circuits. Stress and nicotine augment alcohol-related behaviors, in part via modulation of alcohol-evoked neuronal plasticity and metaplasticity mechanisms. Stress modulates alcohol-evoked plasticity via the release of signaling molecules that influence synaptic transmission. Nicotine also activates some of the same signaling molecules, cells, and circuits, producing a convergence of both stress and nicotine onto common plasticity mechanisms that influence alcohol self-administration. We describe several forms of alcohol-induced plasticity, including classic Hebbian plasticity at glutamatergic synapses, and we highlight less appreciated forms, such as non-Hebbian and GABAergic synaptic plasticity. Risk factors such as stress and nicotine initiate lasting neural changes that modify subsequent alcohol-induced synaptic plasticity and increase the vulnerability to alcohol addiction.
Allocation of Physician Time in Ambulatory Practice
Authors: Steven Bishop, Jeffrey Kushinka, Shin-Ping Tu
Journal: Annals of Internal Medicine (2017)

Letters2 May 2017Allocation of Physician Time in Ambulatory PracticeSteven Bishop, MD, Jeffrey Kushinka, MD, and Shin-Ping Tu, MD, MPHSteven Bishop, MDFrom Virginia Commonwealth University School of Medicine, Chester, Virginia.Search for more papers by this author, Jeffrey Kushinka, MDFrom Virginia Commonwealth University School of Medicine, Chester, Virginia.Search for more papers by this author, and Shin-Ping Tu, MD, MPHFrom Virginia Commonwealth University School of Medicine, Chester, Virginia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0076 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Sinsky and colleagues' study (1) draws some unfortunate but unsurprising conclusions and gives weight to the concerns that we and our associates have had about the practice of medicine for some time. Looking beyond this study, if you could add up the additional time (that is, costs) layered onto practice, you would find an extraordinary tax on the provision of medical care. Physician burnout, workload compression, and other issues related to this taxation are the subjects of much study and scholarship. However, we are concerned that not enough is being done to eliminate or reduce the actual ...References1. Sinsky C, Colligan L, Li L, Prgomet M, Reynolds S, Goeders L, et al. Allocation of physician time in ambulatory practice: a time and motion study in 4 specialties. Ann Intern Med. 2016;165:753-60. [PMID: 27595430]. doi:10.7326/M16-0961 LinkGoogle Scholar2. Hines J. Three sides of Harberger triangles. J Econ Perspect. 1999;13:167-88. CrossrefGoogle Scholar3. Wikipedia. Rent-seeking. 2016. Accessed at https://en.wikipedia.org/wiki/Rent-seeking on 7 September 2016. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Virginia Commonwealth University School of Medicine, Chester, Virginia.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0076. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAllocation of Physician Time in Ambulatory Practice: A Time and Motion Study in 4 Specialties Christine Sinsky , Lacey Colligan , Ling Li , Mirela Prgomet , Sam Reynolds , Lindsey Goeders , Johanna Westbrook , Michael Tutty , and George Blike Allocation of Physician Time in Ambulatory Practice Christine Sinsky , Michael Tutty , and Lacey Colligan Allocation of Physician Time in Ambulatory Practice David P. Serota Allocation of Physician Time in Ambulatory Practice Join Y. Luh Metrics 2 May 2017Volume 166, Issue 9Page: 682-683KeywordsBehaviorConflicts of interestDisclosureEvidence based medicineTaxes ePublished: 2 May 2017 Issue Published: 2 May 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Prevalence of hemolysis and metabolic acidosis in patients with circulatory failure supported with extracorporeal life support: a marker for survival?
Authors: Karla Lehle, Matthias Lubnow, Alois Philipp, Maik Foltan, Florian Zeman, York Zausig, Dirk Lunz, Christof Schmid, Thomas Müller
Journal: European Journal of Heart Failure (2017)
Asthma research in Europe: a transformative agenda for innovation and competitiveness
Authors: Nikolaos G. Papadopoulos, Aggeliki Androutsopoulou, Cezmi Akdis, Sven-Erik Dahlén, Ratko Djukanovic, Jessica Edwards, Luis Garcia-Marcos, Sebastian L. Johnston, Maciek Kupczyk, Thomas R. Martin, David Myles, Susanna Palkonen, Pippa Powell, John Riley, Samantha Walker
Journal: European Respiratory Journal (2017)

Asthma is highly prevalent, often starting in infancy and persisting throughout life, and is associated with high morbidity and burden. It is a major global health challenge with growing impact, affecting more than 300 million people worldwide and at least 10% of all Europeans [1]. Furthermore, it is the most prevalent long-term condition in children [2]. Approximately 5–10% of asthma cases are so severe that current treatments do not work, and over five million people in the European Union (EU) fall into this category. Asthma research in Europe: a transformative agenda for innovation and competitiveness <http://ow.ly/YssR30aNG9h>
Recommendations for the Standardization and Interpretation of the Electrocardiogram
Authors: Paul Kligfield, Leonard S. Gettes, James J. Bailey, Rory Childers, Barbara J. Deal, E. William Hancock, Gerard van Herpen, Jan A. Kors, Peter Macfarlane, David M. Mirvis, Olle Pahlm, Pentti Rautaharju, Galen S. Wagner
Journal: Circulation (2007)

This statement examines the relation of the resting ECG to its technology. Its purpose is to foster understanding of how the modern ECG is derived and displayed and to establish standards that will improve the accuracy and usefulness of the ECG in practice. Derivation of representative waveforms and measurements based on global intervals are described. Special emphasis is placed on digital signal acquisition and computer-based signal processing, which provide automated measurements that lead to computer-generated diagnostic statements. Lead placement, recording methods, and waveform presentation are reviewed. Throughout the statement, recommendations for ECG standards are placed in context of the clinical implications of evolving ECG technology.
Mechanism of Altered Nucleo-Cytoplasmic Traffic of Nucleophosmin in Acute Myelogenous Leukemia Carrying Exon-12 NPM Mutations (NPMc+ AML).
Authors: Brunangelo Falini, Niccolo Bolli, Jing Shan, Maria Paola Martelli, Ildo Nicoletti, Arcangelo Liso, Laura Pasqualucci, Roberto Rosati, Giovanni Roti, Daniela Diverio, Roberta Mannucci, Giovanni Cazzaniga, Andrea Biondi, Giuseppe Saglio, Fabrizio Pane, Francesco Lo-Coco, Pier-Giuseppe Pelicci, Massimo F. Martelli, Wei Gu, Cristina Mecucci
Journal: Blood (2005)
Peptide vaccination in the presence of adjuvants in patients after hematopoietic stem cell transplantation with CD4+ T cell reconstitution elicits consistent CD8+ T cell responses
Authors: Michael Schmitt, Anita Schmitt, Markus Wiesneth, Angela Hückelhoven, Zeguang Wu, Jürgen Kuball, Lei Wang, Peter Schauwecker, Susanne Hofmann, Marlies Götz, Birgit Michels, Birgit Maccari, Patrick Wuchter, Volker Eckstein, Thomas Mertens, Paul Schnitzler, Hartmut Döhner, Anthony D. Ho, Donald W. Bunjes, Peter Dreger, Hubert Schrezenmeier, Jochen Greiner
Journal: Theranostics (2017)

Rationale: Patients receiving an allogeneic stem cell graft from cytomegalovirus (CMV) seronegative donors are particularly prone to CMV reactivation with a high risk of disease and mortality.Therefore we developed and manufactured a novel vaccine and initiated a clinical phase I trial with a CMV phosphoprotein 65 (CMVpp65)-derived peptide.Methods: Ten patients after allogeneic stem cell transplantation received four vaccinations at a biweekly interval.All patients were monitored for CMVpp65 antigenemia.Flow cytometry for CMV-specific CD8 + and γδ T cells as well as neutralizing anti-CMV antibodies were correlated to clinical parameters.Results: The vaccination was well tolerated.Seven of nine patients cleared CMVpp65 antigenemia after four vaccinations and are still free from antigenemia to this day.Two patients with CMV reactivation showed persisting CMV antigenemia.One patient received prophylactic vaccination and did not develop antigenemia.An increase of up to six-fold in frequency of both CMV-specific CD8 + T cells and/or Vδ2negative γδ T cells was detected.Titers of neutralizing antibodies increased up to the tenfold.Humoral and cellular immune responses correlated with clearance of CMV.Conclusion: In summary, CMVpp65 peptide vaccination for patients after allogeneic stem cell transplantation at high risk for CMV reactivation was safe, well tolerated and clinically encouraging.A study in solid-organ transplant patients is ongoing.
Phase I clinical trial of multi-antigen peptide vaccines therapy using cancer-testis antigens for patients with advanced or recurrent breast cancer.
Authors: Tomoyuki Fujita, Atsushi Yoshida, Hajime Nishimura, Kayoko Koshikawa, Naoya Nagura, Koji Yoshida, Yasuo Miyoshi, Hideko Yamauchi, Seigo Nakamura, Yusuke Nakamura, Minoru Fujimori
Journal: Journal of Clinical Oncology (2012)

e13037 Background: Cancer-testis (CT) antigens are proteins that are normally expressed only in the human germline, but are also present in a significant subset of malignant tumors. The practical importance of these proteins is that, due to their restricted expression pattern, they are frequently recognized by the immune system of cancer patients. Moreover, this antigenicity has raised the possibility of their use as vaccines to stimulate immune responses in order to combat tumor growth. As a result, many aspects of CT antigens have been examined in studies performed worldwide. Here we report the results of a phase I clinical trial combining five kinds of CT peptide (CDCA1,URLC10,KIF20A,DEPDC1,MPHOSPH1) vaccination. Methods: The subjects of the trial were HLA-A24-positive patients with metastatic and advanced breast cancer. The mixture of peptides was subcutaneously injected weekly with dose-escalation (doses of 0.5, 1, and 2 mg of each peptide/body, three patients/cohort). Safety, efficacy and immunological parameters were assessed. Results: No adverse events were observed in any patients. Of the 9 patients who completed at least one cycle of the treatment, 4 (44%) developed immunological reactions at the injection site. Specific cytotoxic T lymphocytes (CTLs) reacting to any peptide were induced in 7 (78%) of the 9 patients. Of the 7 patients who completed at least two cycles of the treatment, tumor regression compatible with stable disease (SD) was noted in 4 patients. The remaining patients had progressive disease (PD). The vaccine therapy was tolerable and safe at all doses. Conclusions: Combination therapy with CT antigens has therapeutic potential for patients with breast cancer. Peptide-specific CTLs against peptides in the vaccine were induced at a high rate, even in heavily pretreated patients. From an immunological perspective, the optimal dose for further clinical trials is ≥1 mg/body.
Wnt/beta-catenin pathway: modulating anticancer immune response
Authors: Sachin Gopalkrishna Pai, Benedito A. Carneiro, Jose Mauricio Mota, Ricardo Costa, Caio Abner Leite, Romualdo Barroso-Sousa, Jason Benjamin Kaplan, Young Kwang Chae, Francis Joseph Giles
Journal: Journal of Hematology & Oncology (2017)

Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction. β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/β-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/β-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway.
Estimates of Cancer Deaths Prevented by Raising Cigarette Taxes
Authors: Ryan A. Denu
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 071: Estrogen-related Receptor Gamma Induces Cardiac Hypertrophy By Activating Gata4
Authors: Duk-hwa Kwon, Gwang Hyeon Eom, Hae Jin Kee, Yoonseok Nam, Young Kuk Cho, Don-Kyu Kim, Jayoung Koo, Jeong-Hyeon Ko, Sera Shin, Nakwon Choe, Hosouk Joung, Ha-neul Kim, Hyung Seok Kim, Gwang-Il Nam, In-Kyu Lee, Seung Bum Park, Hueng-Sik Choi, Hyun Kook
Journal: Circulation Research (2013)

Introduction— Estrogen-related receptor gamma (ERRγ) is an orphan nuclear receptor that has biological roles mainly in metabolism and it controls metabolic switching in perinatal heart. In adult heart diseases, however, the functional roles of ERRγ have not yet been elucidated. Hypothesis— In the present study, we aimed to characterize the role of ERRγ in cardiac hypertrophy. Here we show that ERRγ provokes cardiac hypertrophy by inducing GATA4 and that its inverse agonist, GSK-5182, prevents cardiac hypertrophy. Methods and Results— The functional roles of ERRγ in association with development of cardiac hypertrophy were examined in primarily cultured cardiomyocytes, in animal models, and in heart samples from human hypertrophic cardiomyopathy patients. ERRγ expression was increased in hearts obtained from human hypertrophic cardiomyopathy patients and in both agonist-induced cellular models and aortic banding-induced animal models of cardiac hypertrophy. Transgenic overexpression in mouse heart as well as forced expression of ERRγ in cardiomyocytes induced hypertrophic phenotypes. Knock-down of ERRγ blocked agonist-induced hypertrophic phenotypes. ERRγ directly bound to the proximal ERR-responsive element in the GATA4 promoter in a sequence-specific manner and thereby induced transcription. ERRγ-induced hypertrophy was blocked by inhibition of GATA4. GSK-5182 completely blocked cardiac hypertrophy in cardiomyocytes. It also prevented aortic banding-induced cardiac hypertrophy and fibrosis in mouse heart. Conclusion— These findings demonstrate a novel ERRγ/GATA4 signal cascade in the development of cardiac hypertrophy and suggest GSK-5182 as a possible therapeutic.
Addition of gemcitabine to paclitaxel, epirubicin, and cyclophosphamide adjuvant chemotherapy for women with early-stage breast cancer (tAnGo): final 10-year follow-up of an open-label, randomised, phase 3 trial
Authors: Helena M Earl, Louise Hiller, Helen C Howard, Janet A Dunn, Jennie Young, Sarah J Bowden, Michelle McDermaid, Anna K Waterhouse, Gregory Wilson, Rajiv Agrawal, Susan O'Reilly, Angela Bowman, Diana M Ritchie, Andrew Goodman, Tamas Hickish, Karen McAdam, David Cameron, David Dodwell, Daniel W Rea, Carlos Caldas, Elena Provenzano, Jean E Abraham, Peter Canney, John P Crown, M John Kennedy, Robert Coleman, Robert C Leonard, James A Carmichael, Andrew M Wardley, Christopher J Poole
Journal: The Lancet Oncology (2017)
Development of Psycho-Intellectual Performances of Transplanted Sickle Cell Disease Patients: a Prospective Study From Pre-Transplant Period to 5 Years After HSCT.
Authors: Jacqueline Bockenmeyer, Karima Yakouben, Dalila Adjaoud, Brigitte Lescoeur, Marie Ouachée-Chardin, Malika Benkerrou, Jean-Hugues Dalle, Andre Baruchel
Journal: Blood (2009)
Modalities and Effects of Left Ventricle Unloading on Extracorporeal Life support: a Review of the Current Literature
Authors: Paolo Meani, Sandro Gelsomino, Eshan Natour, Daniel M Johnson, Hans‐Peter Brunner La Rocca, Federico Pappalardo, Elham Bidar, Maged Makhoul, Giuseppe Raffa, Samuel Heuts, Pieter Lozekoot, Suzanne Kats, Niels Sluijpers, Rick Schreurs, Thijs Delnoij, Alice Montalti, Jan Willem Sels, Marcel van de Poll, Paul Roekaerts, Thomas Poels, Eric Korver, Zaheer Babar, Jos Maessen, Roberto Lorusso
Journal: European Journal of Heart Failure (2017)
Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project
Authors: Jin Qin, Kamil E. Barbour, Louise B. Murphy, Amanda E. Nelson, Todd A. Schwartz, Charles G. Helmick, Kelli D. Allen, Jordan B. Renner, Nancy A. Baker, Joanne M. Jordan
Journal: Arthritis & Rheumatology (2017)

Objective Symptomatic hand osteoarthritis (OA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated that the lifetime risk of symptomatic knee OA is 45% and that of hip OA is 25%. The objective of the present study was to estimate the overall lifetime risk of symptomatic hand OA, and the stratified lifetime risk according to potential risk factors. Methods Data were obtained from 2,218 adult subjects (ages ≥45 years) in the Johnston County Osteoarthritis Project, a population‐based prospective cohort study among residents of Johnston County, North Carolina. Data for the present study were collected from 2 of the follow‐up cycles (1999–2004 and 2005–2010). Symptomatic hand OA was defined as the presence of both self‐reported symptoms and radiographic OA in the same hand. Lifetime risk, defined as the proportion of the population who will develop symptomatic hand OA in at least 1 hand by age 85 years, was estimated from models using generalized estimating equations. Results Overall, the lifetime risk of symptomatic hand OA was 39.8% (95% confidence interval [95% CI] 34.4–45.3%). In this population, nearly 1 in 2 women (47.2%, 95% CI 40.6–53.9%) had an estimated lifetime risk of developing symptomatic hand OA by age 85 years, compared with 1 in 4 men (24.6%, 95% CI 19.5–30.5%). Race‐specific symptomatic hand OA risk estimates were 41.4% (95% CI 35.5–47.6%) among whites and 29.2% (95% CI 20.5–39.7%) among African Americans. The lifetime risk of symptomatic hand OA among individuals with obesity (47.1%, 95% CI 37.8–56.7%) was 11 percentage points higher than that in individuals without obesity (36.1%, 95% CI 29.7–42.9%). Conclusion These findings demonstrate the substantial burden of symptomatic hand OA overall and in sociodemographic and clinical subgroups. Increased use of public health and clinical interventions is needed to address its impact.
Teaching Medical Students About Conflicts of Interest
Authors: Diane B. Wayne, Marianne Green, Eric G. Neilson
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal