Nalbuphine for Opioid-Induced Urine Retention
Authors: Abdisamad M. Ibrahim, Zainab Obaidi, Gordon Ruan, Dorcas Adaramola, Sharon Onguti
Journal: Annals of Internal Medicine (2018)

Letters18 December 2018Nalbuphine for Opioid-Induced Urine RetentionAbdisamad M. Ibrahim, MD, Zainab Obaidi, MD, Gordon Ruan, MD, Dorcas Adaramola, MD, MPH, and Sharon Onguti, MD, MPHAbdisamad M. Ibrahim, MDSouthern Illinois University School of Medicine, Springfield, Illinois (A.M.I., D.A., S.O.), Zainab Obaidi, MDJohns Hopkins University, Baltimore, Maryland (Z.O.), Gordon Ruan, MDMayo Clinic College of Medicine and Science, Rochester, Minnesota (G.R.), Dorcas Adaramola, MD, MPHSouthern Illinois University School of Medicine, Springfield, Illinois (A.M.I., D.A., S.O.), and Sharon Onguti, MD, MPHSouthern Illinois University School of Medicine, Springfield, Illinois (A.M.I., D.A., S.O.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0387 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Urine retention is common in the hospital setting and is sometimes caused by opioids. Once opioid-induced urine retention develops, resolving it without interfering with pain control can be problematic. For example, naloxone effectively treats opioid-induced urine retention but reverses pain control, which may not be acceptable (1). Intermittent bladder catheterization provides immediate relief but is not a long-term solution because of the cumulative risk for complications.Objective: To show how nalbuphine may help manage opioid-induced urine retention.Case Report: A 59-year-old man with a history of alcoholic cirrhosis was hospitalized for worsening right-sided abdominal pain and diagnosed with portal ...References1. Verhamme KM, Sturkenboom MC, Stricker BH, Bosch R. Drug-induced urinary retention: incidence, management and prevention. Drug Saf. 2008;31:373-88. [PMID: 18422378] CrossrefMedlineGoogle Scholar2. Malinovsky JM, Lepage JY, Karam G, Pinaud M. Nalbuphine reverses urinary effects of epidural morphine: a case report. J Clin Anesth. 2002;14:535-8. [PMID: 12477591] CrossrefMedlineGoogle Scholar3. Dray A, Metsch R. Opioid receptor subtypes involved in the central inhibition of urinary bladder motility. Eur J Pharmacol. 1984;104:47-53. [PMID: 6094211] CrossrefMedlineGoogle Scholar4. Nubain (nalbuphine hydrochloride). Package insert. Chadds Ford, PA: Endo Pharmaceuticals; 2005. Google Scholar Author, Article, and Disclosure InformationAffiliations: Southern Illinois University School of Medicine, Springfield, Illinois (A.M.I., D.A., S.O.)Johns Hopkins University, Baltimore, Maryland (Z.O.)Mayo Clinic College of Medicine and Science, Rochester, Minnesota (G.R.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0387.This article was published at Annals.org on 4 September 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparison of Side Effects of Nalbuphine and Morphine in the Treatment of Pain in children with Cancer: A Prospective StudyUrinary dysfunction in acute brain injury: A narrative reviewHydromorphone 18 December 2018Volume 169, Issue 12Page: 894-895KeywordsAnalgesiaBladderCatheterizationDrugsFood and Drug AdministrationOpioidsSedationUltrasound imagingUrineVomiting ePublished: 4 September 2018 Issue Published: 18 December 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...