tbuckley/cabot-search huggingface dataset:
Abstract 19349: Repaired Tetralogy of Fallot: End- Diastolic Pulmonary Artery Forward Flow Differences Defined by Multimodality Imaging
Authors: Shelby Kutty, Anne M Valente, Matthew T White, Kelsey Hickey, David A Danford, Andrew J Powell, Tal Geva
Journal: Circulation (2016)

Background:  The presence of pulmonary arterial end-diastolic forward flow (EDFF) in patients with repaired tetralogy of Fallot (TOF) is thought to indicate a non-compliant right ventricle. The purpose of our study was to investigate the associations of EDFF with echocardiogram (Echo) and cardiovascular magnetic resonance (CMR) indices of right and left heart function.   Hypothesis:  EDFF is associated with reduced pulmonary regurgitation (PR) and right ventricular (RV) size.   Methods:  We retrospectively analyzed 399 patients with repaired TOF who had Echo and CMR within 1 year of each other. EDFF was defined as the presence of forward flow on the main pulmonary artery or right ventricle-to-pulmonary artery conduit pulsed-wave Doppler Echo trace immediately following atrial contraction in at least 3 consecutive cardiac cycles. CMR measurements included comprehensive volumetric and flow indices of the right and left heart. Variables were summarized by presence or absence of EDFF, and differences compared. Logistic regression was used to assess the univariate associations. Multivariable associations with EDFF were investigated and a forward-selection model building procedure was implemented to identify the most parsimonious model.   Results:  The median age at TOF repair was 0.7 years (0.1-45), patient age was 18.1 years (0.8-72) and interval between Echo and CMR was 48 days (0-364). Diagnoses consisted of TOF/pulmonary stenosis (73%), TOF/pulmonary atresia (24%), and TOF/atrioventricular canal (3%). EDFF was identified in 122 (31%) patients. Compared with those without EDFF, patients with EDFF were younger (p=0.04); had a larger PR fraction (p   Conclusion:  In this large cohort of repaired TOF patients, multimodality noninvasive imaging findings suggest mechanisms beyond right ventricular noncompliance may be responsible for presence of EDFF.
TCT-67 Clinical Relevance of Functionally Insignificant Moderate Coronary Artery Stenosis Assessed by 3-vessel Fractional Flow Reserve Measurement
Authors: Jonghanne Park, Joo Myung Lee, Bon-Kwon Koo, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Doyeon Hwang, Xinyang Hu, Jianan Wang, Fei Ye, Shaoliang Chen, Junqing Yang, Jiyan Chen, Nobuhiro Tanaka, Hiroyoshi Yokoi, Hitoshi Matsuo, Hiroaki Takashima, Yasutsugu Shiono, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2017)
Epidemiology of injuries in juniors participating in top-level karate competition: a prospective cohort study
Authors: Dušana Čierna, Merce Barrientos, Carlos Agrasar, Rafael Arriaza
Journal: British Journal of Sports Medicine (2017)

Background Karate is a popular combat semi-contact sport among juniors, but there are only few studies available on the epidemiology of injuries in karate junior athletes. Aim The aims of this study were to determine the incidence and pattern of injuries in top-level karate competition for athletes aged 16 to 20 years, and to compare injury rates between age groups (ie, under 18-year-old [U18] and under 21-year-old [U21]) and genders, following the introduction of new weight categories. Methods A prospective injury surveillance was undertaken at four consecutive World Karate Championships (2009 to 2015), following the same protocols used in previous investigations. Results During the four championships, a total of 257 injuries were recorded, with an incidence of 41.4/1,000 athlete exposures (AEs, 95% CI 36.4 to 46.3). The injury rate was significantly lower for females with a rate ratio 0.63 (95% CI 0.48 to 0.82). Most of the injuries were minor ones: contusions (n=100), followed by abrasions (n=63) and epistaxis (n=62). Only 10% of the injuries were time-loss injuries (injury incidence rates 4.2/1,000 AEs; 95% CI 2.7 to 6.1). Face injuries represented 69.6% of the injuries, most of them were minor ones (light abrasions 24.5%, epistaxis 24.1%, contusion 16.7%). Change of rules (raising the number of weight categories from three to five) reduced injury incidence in the U21 category. Conclusions The total injury rate in junior competitions is lower compared with elite adult athletes and higher compared with younger elite athletes. Time-loss injuries are rare. The implementation of the new competition categories in U21 karate has been associated with a significant reduction in injury rate.
Tendências recentes da sífilis na Bélgica e desenvolvimento dos sistemas de vigilância das infecções sexualmente transmissíveis
Authors: A Sasse, A Defraye, G Ducoffre
Journal: Eurosurveillance (2004)

Durante os cinco ultimos anos produziramse na Europa uma serie de surtos de sifilis que afetavam principalmente os homems homosexuais [1-5]. Um dos surtos ocorreu em Antuerpia, na Belgica, durante o primeiro trimestre de 2001 [6] e continuou em 2004. Alem disso os diagnosticos de sifilis notificados pela Rede sentinela de laboratorios aumentaram de 89% durante o cuarto trimestre de 2003. Tambem tem sido observado un aumento em Bruxelas durante o mesmo periodo (+300% ; 24 casos). Entre os casos declarados pela rede sentinela, 93,4% eram homens ; dos quais 79,9% tinham relacoes sexuais com outros homens (HRSH). A taxa global de pacientes coinfectados pelo VIH era de 50,5% (HRSH: 58,6%; homens heterossexuais: 23,8%; mulheres: 8,3%) ; 76,1% dos pacientes coinfetados conheciam a sua infeccao pelo VIH no momento do diagnostico de sifilis.
TCT-559 Development and Validation of a Risk Prediction Model for Permanent Pacemaker Implantation after Transcatheter Aortic Valve Replacement
Authors: Abhijeet Dhoble, Pimprapa Vejpongsa, Xu Zhang, Viraj Bhise, Danai Kitkungvan, H.V. Anderson, Prakash Balan, Tuyen C. Nguyen, Anthony Estrera, Richard Smalling
Journal: Journal of the American College of Cardiology (2017)
Cobertura vacinal contra a gripe em indivíduos idosos, Campania (Itália), 1999
Authors: P D'Argenio, B Adamo, R Coluccio, A D'Apice, M. A. Ferrara, F Giugliano, R Parrella, F Peluso, V Romeo, C Ronga, A Simonetti, A Citarella
Journal: Eurosurveillance (2001)

Foi efectuado um estudo sobre a cobertura da vacina contra a gripe entre os individuos idosos. Cinquenta e seis porcento dos entrevistados haviam sido vacinados (cobertura ponderada de 50%), em comparacao com o objectivo de 75%, mas foram referidas taxas mais elevadas nos individuos com idades superiores a 74 anos e naqueles com doencas cronicas.
TCT-234 Trends Of Access And Operative Volume Of Transcatheter Aortic Valve Replacement In The Unites States- Descriptive Analysis
Authors: Ahmad Alkhalil, Richard Hajjar, David Song, Adamantios Tsangaris, Akhtar Amin, Harveen Lamba, Eman Rashed, Shashank Jain, Shervin Golbari, Homam Ibrahim
Journal: Journal of the American College of Cardiology (2017)
Efficacy and Safety of Nivolumab in Asian Patients (Pts) With Advanced Hepatocellular Carcinoma (HCC): Subanalysis of the CheckMate 040 Study
Authors: Masatoshi Kudo, Chiun Hsu, Tae-You Kim, Su-Pin Choo, Yoon-Koo Kang, Ming-Mo Hou, Winnie Yeo, Kazushi Numata, Akhil Chopra, Adyb Baakili, Christine dela Cruz, Huanyu Zhao, Thomas Yau
Journal: Annals of Oncology (2017)
Prescription-Strength Topical Steroids Sold Without Prescription
Authors: Katherine T. Burke, Michelle A. Fricke, Cynthia Marie Carver DeKlotz
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
PS01.01 Treatment Planning in Non-Small Cell Lung Cancer shows Variable Utilization of Multidisciplinary Tumor Board
Authors: J.R. Rayburn, C.L. Wilshire, C.R. Gilbert, B.E. Louie, R.W. Aye, A.S. Farivar, E. Vallières, J.A. Gorden
Journal: Journal of Thoracic Oncology (2017)
A ceramide rheostat balances angiogenesis and anti-angiogenesis
Authors: Jean-Philip Truman, Monica Garcia-Barros, Dolares Hambardzumyan, Branka Stancevic, Daniel Hicklin, Zvi Fuks, Richard Kolesnick, Adriana Haimovitz-Friedman
Journal: Cancer Research (2008)

284  We have previously shown that ionizing radiation (RT) induces rapid sphingomyelin (SM) hydrolysis, generating ceramide and leading to apoptosis in bovine aortic endothelial cells (BAEC) (Haimovitz-Friedman et al., 1994). In these cells, the plasma membrane appeared to be a primary target of RT. Basic fibroblast growth factor (bFGF), an endothelial cell survival factor, inhibited RT-induced BAEC apoptosis in vitro and when injected intravenously prevented RT-induced apoptotic death of small vessels in the mouse small intestine (Paris et al., 2001). Protecting the jejunal microvasculature from RT-induced apoptosis had substantive effects on animal survival by preventing the RT-induced GI syndrome. Mice null for acid sphingomyelinase (ASMase) were similarly protected from RT-induced microvessel apoptosis and the GI syndrome. The current studies address whether bFGF and the angiogenic tumor growth factor vascular endothelial growth factor (VEGF), protect endothelial cells from apoptotic death by regulation of SM/ceramide signaling. bFGF and VEGF each blocked RT-induced ASMase activation in BAEC back to baseline levels (reducing the peak activity at 90 seconds post-RT from 272 nmol/mg/hr to 171 nmol/mg/hr and 193 nmol/mg/hr respectively), and prevented ceramide elevation (455pmol/106 cells 60 seconds post-RT vs. 325pmol/106 cells and 346pmol/106 cells respectively). VEGF, like bFGF, also reduced RT-induced apoptosis from 35% to 9% at 8hrs. Further, treatment of the BAEC clone A19 with antagonistic VEGF-receptor 2 mAb (DC101) increased ceramide levels progressively, which peaked at 1200 pmol/106 cells at 18hrs, leading to apoptosis (45.3% after 24hrs). Finally, in vivo studies using ASMase null and wild-type mice showed that ASMase activation is necessary for DC101-induced radiosensitization of fibrosarcoma tumors. These results strongly suggest that anti-angiogenic pharmacologic agents, delivered immediately prior to single dose radiotherapy, de-repress the enzyme ASMase, allowing enhanced radiation-induced endothelial cell ceramide elevation and apoptosis, translating into markedly improved tumor response.
Identifying and Characterizing circRNA-Protein Interaction
Authors: William W Du, Chao Zhang, Weining Yang, Tianqiao Yong, Faryal Mehwish Awan, Burton B Yang
Journal: Theranostics (2017)

Circular RNAs have been identified as naturally occurring RNAs that are highly represented in the eukaryotic transcriptome.Although a large number of circRNAs have been reported, circRNA functions remain largely unknown.CircRNAs can function as miRNA sponges, thereby reducing their ability to target mRNAs.We hypothesize that circRNAs may bind, store, sort, and sequester proteins to particular subcellular locations, and act as dynamic scaffolding molecules that modulate protein-protein interactions.Here, we review the biological implication and function of circRNA-protein interaction, and reveal a dynamic model of the interaction in various tissues, development stages and physiological conditions.Improved techniques to identify and characterize the dynamic RNA-protein interactions may elucidate the molecular mechanisms associated with the expression and functional diversity of circRNAs.
IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma
Authors: Nirav R. Bhakta, Stephanie A. Christenson, Srilaxmi Nerella, Owen D. Solberg, Christine P. Nguyen, David F. Choy, Kyle L. Jung, Suresh Garudadri, Luke R. Bonser, Joshua L. Pollack, Lorna T. Zlock, David J. Erle, Charles Langelier, Joseph L. Derisi, Joseph R. Arron, John V. Fahy, Prescott G. Woodruff
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Rationale: Quantification of type 2 inflammation provided a molecular basis for heterogeneity in asthma. Non–type 2 pathways that contribute to asthma pathogenesis are not well understood.Objectives: To identify dysregulated pathways beyond type 2 inflammation.Methods: We applied RNA sequencing to airway epithelial brushings obtained from subjects with stable mild asthma not on corticosteroids (n = 19) and healthy control subjects (n = 16). Sequencing reads were mapped to human and viral genomes. In the same cohort, and in a separate group with severe asthma (n = 301), we profiled blood gene expression with microarrays.Measurements and Main Results: In airway brushings from mild asthma on inhaled corticosteroids, RNA sequencing yielded 1,379 differentially expressed genes (false discovery rate < 0.01). Pathway analysis revealed increased expression of type 2 markers, IFN-stimulated genes (ISGs), and endoplasmic reticulum (ER) stress-related genes. Airway epithelial ISG expression was not associated with type 2 inflammation in asthma or with viral transcripts but was associated with reduced lung function by FEV1 (ρ = −0.72; P = 0.0004). ER stress was confirmed by an increase in XBP1 (X-box binding protein 1) splicing in mild asthma and was associated with both type 2 inflammation and ISG expression. ISGs were also the most activated genes in blood cells in asthma and were correlated with airway ISG expression (ρ = 0.55; P = 0.030). High blood ISG expression in severe asthma was similarly unrelated to type 2 inflammation.Conclusions: ISG activation is prominent in asthma, independent of viral transcripts, orthogonal to type 2 inflammation, and associated with distinct clinical features. ER stress is associated with both type 2 inflammation and ISG expression.
Re: Sophia C. Kamran, Thomas Seisen, Sarah C. Markt, et al. Contemporary Treatment Patterns and Outcomes for Clinical Stage IS Testicular Cancer. Eur Urol 2018;73:262–70.
Authors: Christian D. Fankhauser, Nico C. Grossmann, Joerg Beyer, Thomas Hermanns
Journal: European Urology (2017)
Effects of Two Immunosuppressive Treatment Protocols for IgA Nephropathy
Authors: Thomas Rauen, Christina Fitzner, Frank Eitner, Claudia Sommerer, Martin Zeier, Britta Otte, Ulf Panzer, Harm Peters, Urs Benck, Peter R. Mertens, Uwe Kuhlmann, Oliver Witzke, Oliver Gross, Volker Vielhauer, Johannes F.E. Mann, Ralf-Dieter Hilgers, Jürgen Floege
Journal: Journal of the American Society of Nephrology (2017)

The role of immunosuppression in IgA nephropathy (IgAN) is controversial. In the Supportive Versus Immunosuppressive Therapy for the Treatment of Progressive IgA Nephropathy (STOP-IgAN) Trial, 162 patients with IgAN and proteinuria &gt;0.75 g/d after 6 months of optimized supportive care were randomized into two groups: continued supportive care or additional immunosuppression (GFR≥60 ml/min per 1.73 m 2 : 6-month corticosteroid monotherapy; GFR=30–59 ml/min per 1.73 m 2 : cyclophosphamide for 3 months followed by azathioprine plus oral prednisolone). Coprimary end points were full clinical remission and GFR loss ≥15 ml/min per 1.73 m 2 during the 3-year trial phase. In this secondary intention to treat analysis, we separately analyzed data from each immunosuppression subgroup and the corresponding patients on supportive care. Full clinical remission occurred in 11 (20%) patients receiving corticosteroid monotherapy and three (6%) patients on supportive care (odds ratio, 5.31; 95% confidence interval, 1.07 to 26.36; P =0.02), but the rate did not differ between patients receiving immunosuppressive combination and controls on supportive care (11% versus 4%, respectively; P =0.30). The end point of GFR loss ≥15 ml/min per 1.73 m 2 did not differ between groups. Only corticosteroid monotherapy transiently reduced proteinuria at 12 months. Severe infections, impaired glucose tolerance, and/or weight gain in the first year were more frequent with either immunosuppressive regimen than with supportive care. In conclusion, only corticosteroid monotherapy induced disease remission in a minority of patients who had IgAN with relatively well preserved GFR and persistent proteinuria. Neither immunosuppressive regimen prevented GFR loss, and both associated with substantial adverse events.
Back to the Future in Cardiogenic Shock — Initial PCI of the Culprit Lesion Only
Authors: Judith S. Hochman, Stuart Katz
Journal: New England Journal of Medicine (2017)

Approximately 5 to 10% of cases of acute myocardial infarction are complicated by cardiogenic shock, which is associated with early mortality of 40 to 50%.1 Nearly two decades ago, the SHOCK (Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock) trial established that mortality was lower with emergency revascularization than with initial medical stabilization and selective delayed revascularization in patients with ST-segment elevation myocardial infarction (STEMI).2,3 In the SHOCK trial, percutaneous coronary intervention (PCI) of the culprit lesion only was the most common therapy for initial revascularization. Although more complete revascularization might have been expected to have an increased benefit, . . .
Safety Profile of Nivolumab in Japanese NSCLC Pts: Interim Results from Post-marketing All-Case Surveillance in Japan
Authors: Akihiko Genma, Yoichi Nakanishi, Kazuhiko Nakagawa, Nobuyuki Yamamoto, Takeshi Saito, Yasuhiro Tahara, Yuichiro Ohe
Journal: Annals of Oncology (2017)
MicroRNA Expression-Based Model Indicates Event-Free Survival in Pediatric Acute Myeloid Leukemia
Authors: Emilia L. Lim, Diane L. Trinh, Rhonda E. Ries, Jim Wang, Robert B. Gerbing, Yussanne Ma, James Topham, Maya Hughes, Erin Pleasance, Andrew J. Mungall, Richard Moore, Yongjun Zhao, Richard Aplenc, Lillian Sung, E. Anders Kolb, Alan Gamis, Malcolm Smith, Daniela S. Gerhard, Todd A. Alonzo, Soheil Meshinchi, Marco A. Marra
Journal: Journal of Clinical Oncology (2017)

Purpose Children with acute myeloid leukemia (AML) whose disease is refractory to standard induction chemotherapy therapy or who experience relapse after initial response have dismal outcomes. We sought to comprehensively profile pediatric AML microRNA (miRNA) samples to identify dysregulated genes and assess the utility of miRNAs for improved outcome prediction. Patients and Methods To identify miRNA biomarkers that are associated with treatment failure, we performed a comprehensive sequence-based characterization of the pediatric AML miRNA landscape. miRNA sequencing was performed on 1,362 samples—1,303 primary, 22 refractory, and 37 relapse samples. One hundred sixty-four matched samples—127 primary and 37 relapse samples—were analyzed by using RNA sequencing. Results By using penalized lasso Cox proportional hazards regression, we identified 36 miRNAs the expression levels at diagnosis of which were highly associated with event-free survival. Combined expression of the 36 miRNAs was used to create a novel miRNA-based risk classification scheme (AMLmiR36). This new miRNA-based risk classifier identifies those patients who are at high risk (hazard ratio, 2.830; P ≤ .001) or low risk (hazard ratio, 0.323; P ≤ .001) of experiencing treatment failure, independent of conventional karyotype or mutation status. The performance of AMLmiR36 was independently assessed by using 878 patients from two different clinical trials (AAML0531 and AAML1031). Our analysis also revealed that miR-106a-363 was abundantly expressed in relapse and refractory samples, and several candidate targets of miR-106a-5p were involved in oxidative phosphorylation, a process that is suppressed in treatment-resistant leukemic cells. Conclusion To assess the utility of miRNAs for outcome prediction in patients with pediatric AML, we designed and validated a miRNA-based risk classification scheme. We also hypothesized that the abundant expression of miR-106a could increase treatment resistance via modulation of genes that are involved in oxidative phosphorylation.
TCT-327 Trends in cost, length of stay and readmission in acute myocardial infarction patients with diabetic ketoacidosis
Authors: Esteban Aguayo, Aditya Mantha, Young-Ji Seo, Katherine Bailey, Vishal Dobaria, Yen-Yi Juo, Ramin Ebrahimi, Peyman Benharash
Journal: Journal of the American College of Cardiology (2017)
Warmth, competence, and closeness may provide more empirically grounded starts for a theory of sentiments
Authors: Daniel J Hruschka
Journal: Behavioral and Brain Sciences (2017)

Gervais & Fessler dissect the folk concept of "contempt" to argue for a functionally integrated model of attitudes and emotions in the context of social relationships. Existing studies of how evaluations of warmth, competence, and closeness shape people's reactions and behaviors towards others may help in operationalizing and testing the proposed model.
Dos brotes de Salmonella Enteritidis fagotipo 8 vinculados al consumo de queso Cantal elaborado con leche cruda, Francia, 2001
Authors: S Haeghebaert, P Sulem, L Deroudille, E. Vanneroy-Adenot, O Bagnis, P Bouvet, F Grimont, A Brisabois, C. Hervy, E Espié, H de Valk, V Vaillant
Journal: Eurosurveillance (2003)

Las salmonelosis son la causa principal de las infecciones transmitidas por alimentos en los paises industrializados. En Francia, la incidencia de salmonelosis humana registrada en 2001 por el Centro nacional de referencia de salmonelas y shigelas (CNRSS) fue de 21 casos por 100.000 habitantes, y la Salmonella serotipo Enteritidis represento el 39% de los casos (1). Este articulo contiene los resultados de la investigacion de dos brotes comunitarios de salmonelosis que tuvieron lugar simultaneamente en la region suroeste de Francia, y que se vincularon al consumo de queso elaborado con leche cruda.
TCT-103 Long-Term Outcomes of Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: A 16 Year Study
Authors: Christopher Capps, Jeremy Rier, Ashley Waring, Justin Heizer, Barbara Griffin, Shawn Shaji, Akayla Ford, Billy Mullinax, Sheldon Litwin, Christopher Nielsen, Valerian Fernandes
Journal: Journal of the American College of Cardiology (2017)