tbuckley/cabot-search huggingface dataset:
Long-Term Outcome of Autologous Stem Cell Transplantation (ASCT) for Hodgkin Lymphoma (HL) in the ABVD Therapeutic Era.
Authors: Jonathan W. Friedberg, Elizabeth Sensenig, Jennifer Kelly, Jamie Oliva, Louis Constine, Michael Becker, Gordon Phillips, Jane Liesveld, Richard I. Fisher, Steven H. Bernstein
Journal: Blood (2007)
In Chronic Myeloid Leukemia (CML) Patients with Complete Cytogenetic Response to Imatinib, BCR-ABL Kinase Domain Mutations Are Relatively Rare and Not Consistently Associated with Subsequent Relapse.
Authors: Daniel W. Sherbenou, Matthew J. Wong, Adil Humayun, Laura S. McGreevey, Rui Yang, Michael C. Heinrich, Richard D. Press, Brian J. Druker, Michael W. Deininger
Journal: Blood (2005)
PROXIMAL FIFTH METATARSAL STRESS FRACTURES; SCREENING AND TREATMENT FOR INCOMPLETE FRACTURES
Authors: Hiroko Ueki, Tomohiko Tateishi, Saisei AN, Daisuke Hatsushika, Hideyuki Koga, Takashi Ogiuchi
Journal: British Journal of Sports Medicine (2017)

Background Proximal fifth metatarsal stress fractures (so called Jones fractures) usually occur due to chronic repetitive forces. Soccer players on the status of incomplete fracture don't complain about pain while playing soccer; they can keep playing until progressing to the state of complete fractures. Jones fractures are known for prolonged healing time, high rate of non-union and re-injury. Therefore, it is critical to screen athletes with incomplete fracture. Objective To evaluate the effectiveness of "Jones fracture screening" on its prevention for progression from incomplete to complete fracture. Design Prospective cohort study. Setting Collegiate and high school soccer players. Patients Seventy-six players who agreed to participate in the primary screening test. Interventions Educational lectures regarding Jones fracture, questionnaires as well as medical checkup including physical examination and ultrasound were conducted in players' school gymnasium as a primary screening. Hump sign, defined as cortex bulging, and increased blood flow around the fracture area in the Doppler ultrasound were defined as positive. Secondary medical examination with X-rays was then conducted for those who were positive for the primary screening. Players with Jones fractures identified by X-rays were then treated conservatively and followed up until radiographic bone union was achieved. Main Outcome Measurements Radiographic bone union. Results Sixteen players were screened as positive in the primary screening. All positive players received secondary examination, and three players with Jones fracture were identified. Two players had an incomplete fracture and another had an old incomplete fracture. In all players bone union was achieved after conservative treatment without quitting playing soccer. Conclusions The use of ultrasonography would be effective to diagnose incomplete Jones fractures. Jones fracture screening can enlighten about the risk of Jones fractures and may prevent soccer players from progressing from incomplete to complete fracture without quitting playing soccer.
Serum estrogen, but not testosterone levels differ between black and white men in a nationally representative sample of Americans
Authors: Sabine Rohrmann, William G. Nelson, Nader Rifai, Terry Brown, Adrian Dobs, Norma Kanarek, Elizabeth A. Platz
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

465 

Background: Higher serum testosterone levels in black men than in white men has been postulated in some studies to explain the notably higher incidence of prostate cancer in black men. However, previous studies comparing hormone levels between racial groups have been limited by small size, restricted age variation, lack of representativeness, or lack of control for factors that both vary by race and influence hormone levels. Thus, we compared serum concentrations of testosterone, as well as estradiol and sex hormone binding globulin (SHBG), the major carrier of testosterone and estradiol in circulation, in a nationally representative sample of non-Hispanic black, non-Hispanic white, and Mexican-American men. Methods: We performed a cross-sectional study of 1,575 males aged 12+ years who participated in the Third National Health and Nutrition Examination Survey between 1988 and 1991 in the morning examination session. Serum hormone concentrations were measured by competitive electrochemiluminescence immunoassays. Geometric means and 95% confidence intervals were calculated applying sampling weights and adjusting for age, body mass index, alcohol consumption, cigarette smoking, and physical activity using SUDAAN. Results: Non-Hispanic black (n=411, geometric mean 4.76, 95% CI 4.32-5.25 ng/mL), non-Hispanic white (n=716, 4.63, 4.37-4.91 ng/mL), and Mexican-American (n=448, 5.08, 4.70-5.49 ng/mL) men had similar testosterone levels (all p > 0.05). However, non-Hispanic black men (38.02, 35.15-41.12 pg/mL) had a statistically significantly higher mean serum estradiol concentration compared with non-Hispanic white men (33.61, 31.69-35.65 pg/mL, p < 0.05) and Mexican-American men (32.90, 30.42-35.58 pg/mL, p < 0.05); this pattern was present across all ages. Mexican-American men (32.17, 29.74-34.79 nmol/L) had a lower SHBG concentration than either non-Hispanic whites (35.71, 34.34-37.14 nmol/L, p < 0.05) or blacks (37.40, 35.26-39.67 nmol/L, p < 0.01). Conclusions: Contrary to the postulated racial difference in testosterone level, in this large, nationally representative sample there was no difference between non-Hispanic black and white men; Hispanic men had a comparable level. However, black men had the highest estradiol level, which was not explained by racial differences in the prevalence of factors that influence hormone levels. Given these findings, it may be equally, if not more important to investigate levels of estradiol than testosterone in relation to diseases that show racial disparity, such as prostate cancer. Funding: Maryland Cigarette Restitution Fund at Johns Hopkins.
Prognostic value of cell cycle regulators p27 and cyclin E: Tissue microarray analysis of 1753 women enrolled in SWOG breast cancer trial 9313
Authors: P. L. Porter, W. Barlow, I.-T. Yeh, M.-G. Lin, X. Yuan, J. N. Ingle, C. L. Shapiro, G. P. Sledge, R. B. Livingston, D. F. Hayes
Journal: Journal of Clinical Oncology (2005)

507 Background: Abnormal cell proliferation is a common feature of neoplasia and associations between poor clinical outcome and abnormal expression of cell cycle regulatory proteins have been shown in population-based and clinical studies. Methods: Using tissue microarray, we evaluated the prognostic value of cell cycle regulators p27 and cyclin E by IHC in 1,753 of 3,122 (56%) women enrolled in SWOG Intergroup Trial 9313. The protocol compared DFS and OS in women with primary breast cancer who received doxorubicin and cyclophosphamide administered either concurrently (n=1595) or sequentially (n=1527). The two arms of the study showed equivalence of treatment regimens, p=0.26 (Haskell CM; Proc ASCO 21:36a (#142), 2002). Median age was 47 (range 21–76); data collected included race, stage, and menopausal nodal, and ER/PR status. Expression of p27 and cyclin E was rated from 1–7 and dichotomized at the median score for Cox regression analysis. Median follow-up is 7 years. Results: p27 was below median expression (1–5) in 51% and cyclin E above median (4–7) in 47% of tumors. Adjusted for tumor size, number of positive nodes, surgery type, menopause status, and black race, both low p27 and high cyclin E were significant predictors of poorer OS (p=.0001 and.036 respectively) and poorer DFS (p=.0011 and.048 respectively). After adjustment for ER and PR, p27 continued to predict OS (p=.011) and DFS (p=.047); Cyclin E no longer predicted OS (p=.37) or DFS (p=.37). For ER negative tumors, neither cyclin E nor p27 predicted OS or DFS. For ER positive tumors, Cyclin E was not predictive, but p27 predicted OS (p=.002) and DFS (p=.005).The hazard ratio for OS in ER positive women was 0.56 (95% CI 0.39–0.80) in favor of high p27. Conclusions: The study demonstrates the value of TMA in a clinical trial and is the first evaluation of survival by p27 and cyclin E expression in similarly treated women. Low or absent p27 expression in women treated with AC predicted poor OS and DFS. In the subgroup of women with ER positive tumors, it also predicted decreased OS and DFS. Additional large studies are needed to fully understand the relationship between abnormal expression of cell cycle regulators and treatment response. No significant financial relationships to disclose.
Acute Lymphoblastic Leukemia with “Normal” Karyotype is not without Genomic Aberrations.
Authors: Anu Usvasalo, Riikka Räty, Arja Harila-Saari, Pirjo Koistinen, Eeva-Riitta Savolainen, Kim Vettenranta, Sakari Knuutila, Erkki Elonen, Ulla M. Saarinen-Pihkala
Journal: Blood (2008)
PKC412, a Small Molecule Tyrosine Kinase Inhibitor, Regulates Survival and Proliferation Pathways in Waldenström Macroglobulinemia
Authors: Molly R. Melhem, Aldo M. Roccaro, Abdelkareem Azab, Hai T. Ngo, Antonio Sacco, Xiaoying Jia, Feda Azab, Judith Runnels, Nicolas Burwick, Phong Quang, Emanuel N. Husu, Xavier Leleu, Kenneth C. Anderson, Irene M. Ghobrial
Journal: Blood (2008)
Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium
Authors: Roderick Skinner, Renee L Mulder, Leontien C Kremer, Melissa M Hudson, Louis S Constine, Edit Bardi, Annelies Boekhout, Anja Borgmann-Staudt, Morven C Brown, Richard Cohn, Uta Dirksen, Alexsander Giwercman, Hiroyuki Ishiguro, Kirsi Jahnukainen, Lisa B Kenney, Jacqueline J Loonen, Lilian Meacham, Sebastian Neggers, Stephen Nussey, Cecilia Petersen, Margarett Shnorhavorian, Marry M van den Heuvel-Eibrink, Hanneke M van Santen, William H B Wallace, Daniel M Green
Journal: The Lancet Oncology (2017)
The role of palliative resection in metastatic colorectal cancer: 10 years of experiences from a single institute.
Authors: Jin Hyun Park, Kyung-Hun Lee, Sae-Won Han, Do-Youn Oh, Seock-Ah Im, Gyeong Hoon Kang, Eui Kyu Chie, Seung-Yong Jeong, Kyu Joo Park, Jae-Gahb Park, Tae-You Kim
Journal: Journal of Clinical Oncology (2012)

626 Background: Systemic chemotherapy is still mainstay of treatment of metastatic colorectal cancer (mCRC), while the role of palliative resection is not convincing. We intended to find out the role of palliative resection in mCRC. Methods: A total of 1,015 patients were diagnosed with mCRC at Seoul National University Hospital between 2000 and 2009. Except 169 patients who received curative metastectomy of liver and/or lung, 847 patients were retrospectively analyzed. Results: Out of 847 patients, 556 (65.6%) had metastasis at the time of diagnosis and 291 (34.4%) had recurrence after surgery. The median age was 61 (range, 16-88) and 491 (58.0%) were male. The median number of metastatic site was 1 (range, 1-6) and 738 (87.1%) had limited metastasis (number of metastatic site ≤2). The liver was most frequently involved site (451, 53.2%). Surgery was done in 527 (62.2%). One hundred three patients received resection of both primary and metastatic sites (group 1), while 347 and 78 received resection of primary (group 2) and metastatic sties (group 3), respectively. R0 resection was done in 95 patients (G1: 53, G3: 42), while R1/2 was done 431 in patients (G1: 56, G2: 336, G3:39). Of 95 patients with R0 resection, 93 (97.8%) had limited metastasis (number of metastatic organ ≤2) in the peritoneum, lymph nodes, liver, or lung. The median overall survival (OS) was 19.0 months (95% CI, 17.8-20.1) and resected patients had prolonged median OS compared with patients never resected (21.3 vs 14.1 months, p &lt; 0.001). In multivariate analysis, R0 resection was associated with superior OS compared to R2 resection (51.3 vs 18.7 months; HR, 3.0; 95% CI, 1.86 to 4.85, P&lt;0.001), and no resection (51.3 vs 14.1 months; HR, 2.93; 95% CI, 1.73 to 4.96, P&lt;0.001). Palliative chemotherapy was administered in 746 (88.1%), while chemotherapy was not performed in 101 (11.9%) due to patient’s refusal and poor performance status. In multivariate analysis, chemotherapy was also independent prognostic factor for OS (20.4 vs 5.4 months, HR, 3.47; 95% CI, 2.25 to 5.35, P&lt;0.001). Conclusions: Palliative resection with curative intent and chemotherapy confer long-term survival on subsets of mCRC with limited metastasis.
Noninvasive assessment of varices needing treatment in patients with advanced chronic liver disease: No one should be left behind
Authors: Edoardo G. Giannini, Vincenzo Savarino
Journal: Hepatology (2017)

Potential conflict of interest: Nothing to report. TO THE EDITOR: We read with interest the article by Abraldes et al. reporting on several prediction methods to assess noninvasively the presence of esophageal varices needing treatment (VNT) that were retrospectively tested in various cohorts of patients with compensated advanced chronic liver disease in Europe and Canada.1 The authors observed that in patients with VNT, the platelet/spleen ratio (PSR) had a diagnostic accuracy (0.74; 0.67‐0.79) that was not different from the accuracy of the ratio between transient elastography value and PSR (liver stiffness to spleen/platelet score [LSPS]) (Area under the curve [AUC] 0.79; 0.72‐0.84, 95% confidence interval [95%CI]) and was better than liver stiffness measurement alone (AUC = 0.67; 0.59‐0.72, 95% CI), suggesting that both PSR and LSPS could be used to identify a subset of patients with compensated advanced chronic liver disease where endoscopy could be safely avoided.2 We feel that the results reported in this study are relevant for the management of patients and decisions regarding the most appropriate allocation of limited resources, such as endoscopy. However, we also feel that when assessing the accuracy of a diagnostic test, all patients who could benefit from application of the test should be included in the analysis. Transient elastography, which is part of the LSPS as well as of all the other noninvasive tests considered in this study (except the PSR), is a diagnostic test with a nonnegligible rate of unreliable measurements or failures.3 In particular, a French study including 13,369 examinations revealed a 3.1% failure rate and 15.8% unreliability rate for liver stiffness measurements, figures confirmed by a Chinese study that recorded failure and unreliability rates of 2.7% and 11.6%, respectively.3 Therefore, we suggest that the results reported by Abraldes et al. should be corrected in an “intention‐to‐test” analysis in which unreliable measurements and failure of transient elastography are included in the analyses and are considered failures of the diagnostic test, given that these patients are recommended for endoscopy from a practical perspective. On the contrary, spleen bipolar diameter can always be determined and is highly reproducible in patients with compensated cirrhosis.5
FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia
Authors: Jo Ishizawa, Eiji Sugihara, Shinji Kuninaka, Kaoru Mogushi, Kensuke Kojima, Christopher B. Benton, Ran Zhao, Dhruv Chachad, Norisato Hashimoto, Rodrigo O. Jacamo, Yihua Qiu, Suk Young Yoo, Shinichiro Okamoto, Michael Andreeff, Steven M. Kornblau, Hideyuki Saya
Journal: Blood (2017)
The folly of boxology
Authors: Diane M Beck, John Clevenger
Journal: Behavioral and Brain Sciences (2016)

Abstract Although the authors do a valuable service by elucidating the pitfalls of inferring top-down effects, they overreach by claiming that vision is cognitively impenetrable. Their argument, and the entire question of cognitive penetrability, seems rooted in a discrete, stage-like model of the mind that is unsupported by neural data.
Clusterin attenuates the development of renal fibrosis (Journal of the American Society of Nephrology (2012) 23, (73-85))
Authors: G. S. Jung, M. K. Kim, Y. A. Jung, H. S. Kim, I. S. Park, B. H. Min, K. U. Lee, J. G. Kim, K. G. Park, I. K. Lee
Journal: Journal of the American Society of Nephrology (2012)
Giant pulmonary hydatid cyst
Authors: Chenglin Guo, Qiang Pu, Jiandong Mei, Lunxu Liu
Journal: Thorax (2017)

A 34-year-old Tibetan man presented with a 4-month history of progressive chest pain and dyspnoea. On direct questioning, his diet consisted of eating raw beef. On examination, there were no breath sounds auscultated on the right. Chest X-ray and CT revealed a giant cystic lesion occupying the right hemithorax (figure 1). There were no other cysts shown on the brain and abdominal CT scans. The serological haemagglutination test for echinococcosis was positive.



Figure 1 
(A) Chest X-ray showed a high-density shadow. …
Improved Outcome in Adult T-ALL by Risk Adapted Treatment Strategies.
Authors: Nicola Goekbuget, Eckhard Thiel, Joachim Beck, Frank Griesinger, Frank Hartmann, Kathleen Jentsch-Ullrich, Sabine Knipp, Thomas Lipp, Dorle Messerer, Bernd Metzner, Jan Rutjes, Mathias Schmid, Stefan Schwartz, Peter Staib, Matthias Stelljes, Dieter Hoelzer
Journal: Blood (2004)
Coronary Angiography and Percutaneous Coronary Intervention After Out-of-Hospital Cardiac Arrest
Authors: Shaker M. Eid, Aiham Albaeni, Nisha Chandra-Strobos
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Combination of Lenalidomide with R-CHOP (R2CHOP) Is Well-Tolerated and Effective As Initial Therapy for Aggressive B-Cell Lymphomas - A Phase II Study
Authors: Grzegorz S. Nowakowski, Betsy R. LaPlant, Craig Reeder, James M. Foran, Luis F. Porrata, William R Macon, Patrick B. Johnston, Candido E. Rivera, Thomas M Habermann, David J. Inwards, Ivana N. Micallef, Garth D Nelson, Stephen M. Ansell, Thomas E. Witzig
Journal: Blood (2012)
Crossmodal processing and sensory substitution: Is “seeing” with sound and touch a form of perception or cognition?
Authors: Tayfun Esenkaya, Michael J Proulx
Journal: Behavioral and Brain Sciences (2016)

Abstract The brain has evolved in this multisensory context to perceive the world in an integrated fashion. Although there are good reasons to be skeptical of the influence of cognition on perception, here we argue that the study of sensory substitution devices might reveal that perception and cognition are not necessarily distinct, but rather continuous aspects of our information processing capacities.
From Muslim Registries to Radical Health Care Reform—Caring for Patients in an Era of Political Anxiety
Authors: Reshma Jagsi
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Clonality in Granulocytes Detected by an Improved HUMARA Assay: A Good Prognostic Marker in Bone Marrow Failure Patients Exhibiting Chromosomal Abnormalities of Indefinite Significance.
Authors: Ken Ishiyama, Chiharu Sugimori, Hirohito Yamazaki, Akiyoshi Takami, Shinji Nakao
Journal: Blood (2004)
Novel treatment protocol for ameliorating refractory, chronic pain in patients with autosomal dominant polycystic kidney disease
Authors: Niek F. Casteleijn, Maatje D.A. van Gastel, Peter J. Blankestijn, Joost P.H. Drenth, Rosa L. de Jager, Anna M. Leliveld, Ruud Stellema, Andreas P. Wolff, Gerbrand J. Groen, Ron T. Gansevoort, J.P.H. Drenth, J.W. de Fijter, R.T. Gansevoort, D.J.M. Peters, J. Wetzels, R. Zietse
Journal: Kidney International (2017)
CD45-CD34+ Endothelial Progenitor Cells (EPCs) from Human Adipose Tissue Promote Tumor Growth and Metastases
Authors: Patrizia Mancuso, Ines Martin Padura, Giuliana Gregato, Paola Marighetti, Angelica Calleri, Chiara Corsini, Giancarlo Pruneri, Visnu Lohsiriwat, Jean Yves Petit, Francesco Bertolini
Journal: Blood (2011)
Sequential Therapy with Ofatumumab, High Dose Methylprednisolone and Lenalidomide Is a Safe and Effective Regimen for the Treatment of Previously Treated and Untreated CLL/SLL: The Hilo Trial
Authors: Javier Pinilla-Ibarz, Julio C Chavez, Elyce Turba, Lisa Nodzon, Jennifer rock-Klotz, Samir Dalia, Rami S. Komrokji, Frederick L. Locke, Mohamed A Kharfan-Dabaja, Celeste M. Bello
Journal: Blood (2015)
Safety and Efficacy of Intrathecal Liposome-Encapsulated Cytarabine for Central Nervous System (CNS) Prophylaxis in Adult Patients with Burkitt and Atypical Burkitt Lymphoma Treated with the R-CODOX-M/R-IVAC (Magrath) Regimen: Results of a Phase II Study.
Authors: Ferdinando Frigeri, Filippo Russo, Manuela Arcamone, Chiara Fraira, Gennaro Russo, Gaetana Capobianco, Cristina Becchimanzi, Arturo Cuomo, Gianpaolo Marcacci, Gennaro Esposito, Rosaria De Filippi, Gaetano Corazzelli, Umberto Vitolo, Antonio Pinto
Journal: Blood (2009)
Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia: Similar Efficacy of Non-Myeloablative and Myeloablative Conditioning; Long-Term Evaluation From the University of Minnesota.
Authors: Brian McClune, Linda J. Burns, Todd E. DeFor, Arne Slungaard, Veronika Bachanova, Claudio Brunstein, Daniel J. Weisdorf
Journal: Blood (2009)