tbuckley/cabot-search huggingface dataset:
TMOD-24. FLUORESCEIN GUIDED SURGERY FOR MALIGNANT BRAIN TUMORS: A CASE SERIES WITH A LOW COST DEVICE
Authors: Renan Maximilian Lovato, João Luiz Vitorino Araujo, Aline Lariessy Campos Paiva, José Carlos Esteves Veiga
Journal: Neuro-Oncology (2017)

Gross total resection for malignant brain neoplasms is an important oncological principle and a major part of the treatment with crucial impact on prognosis. It is a challenge due to the heterogeneity of these lesions and its infiltration in eloquent areas. Some resources are useful to maximize the extension with safety and minimal sequelae. Fluorescence guided surgery is a safe, cheap and important tool that improves the rate of total resection. It is described a case series in which fluorescein is used in malignant brain tumor surgeries (for gliomas and metastasis). We have built a 3D printed device with an excitation and a barrier filter to use in surgical microscopes. The patients received an intravenous dose sodium fluorescein before skin incision. Surgical view under white light was compared to the use of the light filters. In all cases with the use of our device the tumors showed a high fluorescence, but not in the normal surrounding brain. This tool makes easier to identify the lesion and to achieve gross total resection with minimum damage to neighboring tissue. Fluorescence guided surgery increases the rate of gross total resection of malignant brain tumors. This is an important tool with a potential impact on overall survival of the patients. This is a low cost option that could make this technology available in low resources areas.
P1.14-001 The Feasibility of Predicting Radiation Pneumonitis Using Lung Equivalent Uniform Dose (LEUD) in Volumetric-Modulated Arc
Authors: X. Li, J. Gu, C. Wang, Q. Deng, S. Ma, Y. Ren, L. Xing, T. Niu
Journal: Journal of Thoracic Oncology (2017)
Intervention studies to foster resilience – A systematic review and proposal for a resilience framework in future intervention studies
Authors: A. Chmitorz, A. Kunzler, I. Helmreich, O. Tüscher, R. Kalisch, T. Kubiak, M. Wessa, K. Lieb
Journal: Clinical Psychology Review (2017)

Psychological resilience refers to the phenomenon that many people are able to adapt to the challenges of life and maintain mental health despite exposure to adversity. This has stimulated research on training programs to foster psychological resilience. We evaluated concepts, methods and designs of 43 randomized controlled trials published between 1979 and 2014 which assessed the efficacy of such training programs and propose standards for future intervention research based on recent developments in the field. We found that concepts, methods and designs in current resilience intervention studies are of limited use to properly assess efficacy of interventions to foster resilience. Major problems are the use of definitions of resilience as trait or a composite of resilience factors, the use of unsuited assessment instruments, and inappropriate study designs. To overcome these challenges, we propose 1) an outcome-oriented definition of resilience, 2) an outcome-oriented assessment of resilience as change in mental health in relation to stressor load, and 3) methodological standards for suitable study designs of future intervention studies. Our proposals may contribute to an improved quality of resilience intervention studies and may stimulate further progress in this growing research field.
Prospective generation of PDTX (patient derived tumor xenografts) and molecular profiling of NSCLC (non small cell lung cancer)
Authors: T. Mele, F. Cottino, M. Busso, D. Sardo, F. Guerrera, L. Costardi, E. Ruffini, F. Maletta, L. Righi, S. Vatrano, M. Volante, G.V. Scagliotti, S. Novello, L. Trusolino
Journal: Annals of Oncology (2017)
Epidémies de Salmonella enterica monophasique sérotype 4,[5],12:i au Luxembourg, 2006
Authors: J Mossong, P Marques, C Ragimbeau, P Huberty-Krau, S Losch, G Meyer, G Moris, C Strottner, W Rabsch, F Schneider
Journal: Eurosurveillance (2007)

Une Salmonella enterica monophasique serotype 4,[5],12:i de type de bacteriophage DT193 est apparue comme le serotype dominant au Luxembourg en 2006 causant deux importantes epidemies: 133 cas confirmes en laboratoire ont ete declares ainsi que 24 hospitalisations et un deces.
Correction to: 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society
Journal: Circulation (2017)

several corrections were needed.1.In the table of contents and the corresponding headings in the text, a colon and the word "Recommendations" have been added to headers for the following sections: 3.2., 3.3., 4.1.,4.2., 4.3., 5., 6., and 10. 2. On page e64, in Section 1.2., the first sentence read, "The writing committee was composed of clinicians with expertise in caring for patients with syncope, including cardiologists, electrophysiologists, a neurologist, an emergency physician, and a pediatric cardiologist."The words "a neurologist" have been deleted.The sentence is updated to read, "The writing committee was composed of clinicians with expertise in caring for patients with syncope, including cardiologists, electrophysiologists, an emergency physician, and a pediatric cardiologist."3. On page e64, in Section 1.3., second paragraph, the first sentence read, "This document was approved for publication by the governing bodies of the ACC, AHA, and HRS and was endorsed by the Pediatric and Congenital Electrophysiology Society."It is updated to read, "This document was approved for publication by the governing bodies of the ACC, AHA, and HRS and was endorsed by the American College of Emergency Physicians, the Society of Academic Emergency Medicine, and the Pediatric and Congenital Electrophysiology Society."The endorsing bodies text is also updated on page e60, the title page.4. On page e70, in Table 5, "Short-and Long-Term Risk Factors," the column headed "Long-Term Risk Factors (>30 d)," the entry for "Older age" previously read, "Older age. 90" It is updated to read, "Older age. 67,74,75,90 " 5. On page e77, in the Section 3.3.2.recommendation table, "Recommendations for Neurological Diagnostics," first IIa recommendation explanatory text, the second sentence read, "ECG findings are characteristic if an episode can be induced during the tilt-table testing. [261][22][263] " "ECG" has been replaced with "EEG."The sentence is updated to read, "EEG findings are characteristic if an episode can be induced during the tilt-table testing. 261-263" 6.On page e79, in the Section 4.1.1.recommendation table, "Recommendation for Bradycardia," the first sentence of the explanatory text read, "A search and review of papers on syncope and bradycardia has been performed since the last guidelines were published in 2008 and 2012. 12,264" It is updated to read, "A search and review of papers on syncope and bradycardia has been performed since the last updated guidelines were published in 2012.
La vigilancia de las infecciones invasivas meningocócicas en la República Checa
Authors: P Kriz
Journal: Eurosurveillance (2004)

La notificacion de rutina de las infecciones meningococicas invasivas tiene una larga tradicion en la Republica Checa, existiendo datos de mortalidad disponibles desde 1921 y de morbilidad desde 1943. En el laboratorio nacional de referencia de las infecciones meningococicas de Praga, se conservan desde 1970 mas de 3.500 cepas de Neisseria meningitidis, procedentes de casos de infecciones invasivas y de sus c ontactos, de portadores sanos y de casos de infecciones respiratorias. El analisis de estas cepas muestra que la poblacion afectada por esta enfermedad en la Republica Checa es diferente de la observada en Europa occidental. En 1993, la incidencia de las infecciones meningococicas de serogrupo C aumento, estando asociado este aumento a la emergencia del complejo Neisseria meningitidis C, ST-11, ET-15/37, sumamente virulento. Este complejo fue el responsable del aumento de la incidencia de la enfermedad meningococica, alcanzando su maximo valor en 1995 (2,2/100.000). En consecuencia, se establecio en el pais una estrategia vacunal dirigida hacia la poblacion con mayor riesgo para estas infecciones meningococicas invasivas.
OA 06.06 Chr15q25 Locus Confers Risk of Lung Cancer, COPD and Smoking: Triple Whammy Effect in the ACRIN NLST Sub-Study (N=9,270)
Authors: R. Hopkins, F. Duan, E. Greco, C. Chiles, G. Gamble, D. Aberle, R. Young
Journal: Journal of Thoracic Oncology (2017)
Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS
Authors: Takao Omura, Kumiko Omura, Andrea Tedeschi, Priscilla Riva, Michio W. Painter, Leticia Rojas, Joshua Martin, Véronique Lisi, Eric A. Huebner, Alban Latremoliere, Yuqin Yin, Lee B. Barrett, Bhagat Singh, Stella Lee, Tom Crisman, Fuying Gao, Songlin Li, Kush Kapur, Daniel H. Geschwind, Kenneth S. Kosik, Giovanni Coppola, Zhigang He, S. Thomas Carmichael, Larry I. Benowitz, Michael Costigan, Clifford J. Woolf
Journal: Neuron (2016)
Outcomes in Asymptomatic Redo Carotid Endartectomy
Authors: Rishi A. Roy, Gilbert R. Upchurch
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Vigilancia del paludismo en los países de la Unión Europea
Authors: F Legros, M Danis
Journal: Eurosurveillance (1998)

El paludismo es la enfermedad parasitaria mas importante del mundo (1,2). Es endemica en 91 paises, donde cada ano se estima que se dan entre 300 y 500 millones de casos clinicos. Los casos graves de paludismo se dan principalmente en los tropicos. Es la septima causa mas comun de muerte, responsable de unos dos millones de muertes al ano, y su control sigue siendo prioritario para la sanidad publica.
Considerations for County-Level Inequalities in Life Expectancy
Authors: Carlos de Mestral
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
P2.09-004 PD-L1 Protein Expression Is Negative Prognostic Factor in Malignant Pleural Mesothelioma in Central Europe
Authors: L. Brcic, M. Jakopovic, I. Kern, K. Mohorcic, S. Seiwerth, M. Grusch, M. Rajer, A. Buder, T. Klikovits, V. Laszlo, B. Dome, B. Hegedus, W. Klepetko, V. Kolek, R. Pirker, M. Hoda, M. Filipits
Journal: Journal of Thoracic Oncology (2017)
Thyroid Dysfunction in Torsades de Pointes
Authors: Ali A. Rizvi
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
NIMG-44. ROLE OF PRE-TREATMENT TUMOR DYNAMICS AND IMAGING RESPONSE IN DISCRIMINATING GLIOBLASTOMA SURVIVAL FOLLOWING GAMMA KNIFE
Authors: Kyle W Singleton, Sandra K Johnston, Cassandra R Rickertsen, Gustavo De Leon, Lauren R Kunkel, Jason Rockhill, Maciej Mrugala, Bernard Bendok, Naresh Patel, Alyx Porter, Kristin R Swanson
Journal: Neuro-Oncology (2017)

Glioblastoma (GBM) is a notoriously deadly cancer with poor prognosis following tumor progression. Stereotactic radiosurgery (SRS) is advantageous for localized treatment of new tumor burden thus controlling cumulative radiation dose to normal tissue. However, post-treatment effect and tumor progression are difficult to decipher due to transient effects seen on subsequent contrast-enhanced MRI’s. In this work, we investigated Days Gained (DG), our previously reported personalized response metric, for discriminating overall survival following gamma knife SRS. A retrospective analysis was performed on 17 GBM patients who received gamma knife SRS at first tumor recurrence. Tumor volumes were segmented on T1GD and FLAIR MRI at three imaging timepoints (2 prior to therapy, 1 at approximately 1-month post-SRS). Pre-treatment tumor growth velocity (Vpre) was computed and used to estimate DG. Kaplan-Meier and Cox proportional hazard analysis compared DG and Vpre for discriminating survival since the start of treatment. Kaplan-Meier and Cox analysis identified thresholds of DG that discriminate survival for T1Gd (DG>34.5, p=0.008) and FLAIR (DG>11.6, p=0.026). This significance was retained when treating DG as a continuous variable for FLAIR (HR=0.996, p=0.030) but not for T1Gd (p=0.32). An Vpre threshold of 14.6 mm/year (p=0.021) was found for T1GD which was significant in univariate Cox analysis (HR=1.03, p=0.023) and after controlling for age and sex (HR=1.034, p=0.009). No significant thresholds were found for FLAIR velocity. Identified DG thresholds were lower than previous analyses for other treatments. This suggests the typical 1-month follow-up interval after SRS may be suboptimal in identifying clinically significant response measured using DG. Significant discrimination using T1GD velocity is also suggestive that transient enhancement may confound DG. Further analysis is needed to determine if later follow-up images improve prediction. Aggressive tumor growth prior to SRS and low Days Gained are poor prognostic indicators for gamma knife.
Triquinosis asociada al cerdo: ¿ha surgido un nuevo modo de transmisión?
Authors: J C Desenclos
Journal: Eurosurveillance (1999)

En este numero, Eurosurveillance publica un informe sobre dos brotes de triquinosis –de ocho y 44 casos, respectivamente– acontecidos en Alemania en el estado de Westfalia-Renania del Norte entre octubre y diciembre de 1998. Los vehiculos de infeccion pudieron ser identificados gracias a las buenas investigaciones epidemiologicas realizadas: una carne picada de cerdo, comercializada por un supermercado, en el brote mas pequeno, y salchichas ahumadas crudas, fabricadas por una compania, en el segundo brote. En restos de la carne picada de cerdo, aunque no asi en las salchichas ahumadas crudas, se detectaron larvas de Trichinella spiralis.
BRCA1/BRCA2 mutations in a Mediterranean population (Apulia Region) with breast or ovarian cancer: a single center experience
Authors: M. Caloro, L. Orlando, E.S. Lutrino, A. Quaranta, C. Caliolo, P. Schiavone, G. Aprile, M.C. Chetrì, M. D'Amico, P. Rizzo, P. Fedele, D. Loparco, E. Mazzoni, A. Marino, N. Calvani, F. Sponziello, A. Nacci, M. Cinefra, P. Ferrara, S. Cinieri
Journal: Annals of Oncology (2017)
IMMU-40. ROLE OF HUMAN-β-DEFENSIN 3 IN GLIOBLASTOMA MULTIFORME
Authors: Amber Kerstetter-Fogle, Peggy Harris, Alankrita Raghavan, Jill Barnholtz-Sloan, Marta Couce, Ge Jin, Aaron Weinberg, Andrew Sloan
Journal: Neuro-Oncology (2017)

Glioblastoma multiforme (GBM) is the most common primary brain tumor with current therapies offering only palliative benefit. Cellular hierarchy in GBM is maintained by the presence of cancer stem cells (CSCs), which have the capability for self-renewal and proliferation. We investigated the immunomodulatory effects of the cancer stem cell-niche by examining the secretion of defensins – specifically human b-defensin 3 (hBD-3) - and their interactions with macrophages and microglia. Immunohistochemistry of primary tumor sections revealed the presence of hBD-3 in the tumor periphery. Co-localization of hBD-3 with stem cell markers Sox2 and Nestin demonstrates that the hBD-3 expressing cells were CSCs. IHC also revealed the presence of CD68+ macrophages alongside HBD-3 expressing Sox2+ CSCs. CSCs were isolated from primary GBM tumors by FACS using CD15 and CD133 as markers. QT-PCR revealed an increase in the expression of HBD-3 in purified CSCs compared to control hNSCs cell lines. Peripherally derived MDSCs from patients with primary GBM did not express hBD-3. Chemotaxis assays indicate the ability of recombinant hBD-3 to chemoattract macrophages and microglia associated with GBM. HBD-3 is secreted by cancer stem cells and plays a role in immunomodulation. The ability of hBD-3 to attract macrophages suggests that it may play a role in the M1 to M2 phenotype switch of macrophages – thereby allowing for immune evasion. Future experiments include blocking myeloid cell expressing chemotactic receptors to determine their role in hBD-3 mediated chemotaxis. Additionally, in vivo shRNA experiments to knock down hBD-3 expression by CSCs in murine models of GBM will be done to definitively show its role in GBM immunomodulation. Understanding the role of immune cells in the tumor microenvironment is essential for development of new therapies for treatment of GBM.
QLIF-44. SLEEP DISTURBANCE IN ADULTS WITH PRIMARY BRAIN TUMORS AND THEIR FAMILY CAREGIVERS
Authors: Lin Lin, Lung-Chang Chien, Kathryn Lee, Steven Paul, Christine Miaskowski
Journal: Neuro-Oncology (2017)

While patients with brain tumors (BT) report sleep disturbances during radiation therapy (RT), no study has compared patients and their family caregivers (FCs). This study examined changes in total sleep time (TST) in patients and FCs during and after RT. From a longitudinal study on fatigue, pain, and sleep disturbance during RT for various types of cancer, patients with BT and their FCs were selected for this analysis. They completed the initial assessment at simulation (baseline) and were followed weekly (7 times) during RT, then bi-weekly (4 times) and monthly (2 time points) after completion of RT. Sleep measures were obtained with wrist actigraphy over 48 hours at each time point. Data were analyzed using mixed models. Patients (n=13) were 50.6 ± 16.8 years old, primarily white (69%), and female (69%). FCs (n=7) were older (64.8 ± 6.8), primarily white (86%), and male (71%). Although baseline TST was similar (patients=386 ± 20; FCs=384 ± 27 minutes), FCs slept significantly less than patients across time (p<.001), averaging <7 hours during RT. Patients’ TST gradually increased over time during RT, but did not differ between any two consecutive time points. By week 6, patients slept significantly more (457 ± 23 minutes) than baseline (p<.05). At the final 4 post-RT assessments, patients maintained >7 hours (p<.05) while FCs averaged <6 hours. Results are consistent with prior reports that patients sleep more as early as week 1 after the initiation of RT. FCs’ sleep disturbance was associated with greater fatigue and less social support in other studies. Although FCs’ TST did not differ over time from baseline, short sleep duration continued at 4 months post-RT. FCs need to be more cautious with daytime activities such as driving and may require additional assistance during this vulnerable period. Other sleep characteristics and demographic and clinical factors should be considered in future analyses.
EXTH-02. PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF 5-AZACYTIDINE ALONE AND IN COMBINATION WITH INULIN IN A NON-HUMAN PRIMATE MODEL
Authors: Cynthia Lester McCully, Louis Rodgers, Rafael Cruz, Marvin Thomas, Cody Peer, William D Figg, Katherine E Warren
Journal: Neuro-Oncology (2017)

To evaluate the CNS exposure of 5-azacytidine (5-AZA) plasma and CSF pharmacokinetics (PK) and cortical extracellular fluid (ECF) concentrations, via microdialysis (MD), were studied in a nonhuman primate model (NHP) following intravenous (IV), intranasal (IN), intraventricular (IT-V), intralumbar (IT-L) administration. 5-AZA was administered to 8 rhesus macaques; IV (3.75 mg/kg), IN (20 mg), IT (10 mg). 5-AZA with Inulin was administered IT-V (5-AZA-10mg/Inulin-2mg) to examine IT clearance. Cortical ECF, plasma, CSF, and tissue were collected. 5-AZA levels were quantified via an uHPLC-MS/MS assay and PK parameters calculated using non-compartmental methods. Mean Data. IV: Plasma AUC0-∞ 2.93 hr*uM and Clearance (CL) 107.2 L/hr/m2. IN: Plasma AUC0-∞ 0 hr*uM 5-AZA CSF concentrations were not quantifiable for IV or IN administration. IT-V: Plasma: AUC0-∞ 0.29 hr*uM and CL 353.4 L/hr/m2 CSF: AUC0-∞ 2902.9 hr*uM and CL 0.308 ml/min IT-L: Plasma: AUC0-∞ 0.46 hr*uM and CL 222.9 L/hr/m2 CSF: AUC0-∞ 12.8 hr*uM and CL 61.91 ml/min Inulin IT-V: Plasma: AUC0-∞ 11.84 hr*uM and CL 1.6 L/hr/m2 CSF: AUC0-∞ 7874.5 hr*uM and CL 0.018 ml/min. Inulin (w/5-AZA) IT-V: Plasma: AUC0-∞ 0 hr*uM CSF: AUC0-∞ 7752.5 hr*uM, and CL 0.018 ml/min 5-AZA (w/Inulin) IT-V: Plasma: AUC0-∞ 0 hr*uM CSF: AUC0-∞ 1976.6 hr*uM and CL 0.410 ml/min MD/PK IT-V: Plasma: AUC0-∞ 0.158 hr*uM and CL 391.6 L/hr/m2 CSF: 583.9 AUC0-∞ hr*uM and CL 2.36 ml/min. 5-AZA concentrations were not quantifiable for ECF. Tissue: Percentage of total dose recovered in tissue: Brain 1.7% distributed as Cortex 71%, Pons 4%, Medulla 5%, Cerebellum 20%. 0% recovered in liver and kidney. IT administration is necessary to achieve significant 5-AZA exposure in the CSF. 5-AZA clearance is not equivalent across the CSF space and is greater than bulk flow. Following IT delivery, 5-AZA does not remain in the ECF but is swiftly incorporated into brain tissue.