tbuckley/cabot-search huggingface dataset:
Promoter hypermethylation in APC, GSPT1 and RUNX3 and long-term mortality of prostate cancer patients
Authors: Lorenzo Richiardi, Valentina Fiano, Laura De Marco, Loredana Vizzini, Anna Gillio-Tos, Franco Merletti
Journal: Cancer Research (2007)

3417  Recent studies suggested that CpG island hypermethylation at promoter of specific genes may be used to discriminate between malignant and benign prostate disease and correlates with prostate cancer recurrence. We investigated whether detection of CpG island promoter hypermethylation at three genes (APC, GSPT1 and RUNX3) at the time of the cancer diagnosis is associated with long-term mortality.  We identified 302 consecutive patients diagnosed with prostate cancer at a pathology ward of the main hospital of Turin, Italy, between 1982 and 1988. For each patient, slices of paraffin embedded tumor tissue and information on tumor characteristics reported in the pathology reports were obtained. Adequate genomic DNA was extracted from 232 patients (77%) of the slices. Methylated status was tested using bisulfite modification and methylation specific PCR. Patients with known methylated status were followed-up for mortality until 2006 (12 were lost to follow-up).  Overall, 220 patients were followed up for a median of 3 years (range: 0-22). For each gene, the methylated status was not associated with age at cancer diagnosis or grade of tumor differentiation. Both promoter hypermethylation at APC and the grade of differentiation were independent predictors of the overall mortality (Table 1). The hazard ratio of overall mortality increased with the number of hypermethylated genes: we found a hazard ratio of 1.62 (95% confidence intervals 1.07-2.45) for three methylated genes compared with one methylated gene (Table 1).  Detection of promoter CpG island hypermethylation at APC and the number of hypermethylated genesat the time of prostate cancer diagnosis were suggested to be early markers of cancer development independent from the grade of tumor differentiation. Analyses on prostate cancer-specific mortality will be carried out to support these findings. Acknowledgments: this work has been supported by the Italian Association for Cancer Research (AIRC).
A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma: a retrospective training and validation analysis in three international cohorts
Authors: Sarah Huet, Bruno Tesson, Jean-Philippe Jais, Andrew L Feldman, Laura Magnano, Emilie Thomas, Alexandra Traverse-Glehen, Benoit Albaud, Marjorie Carrère, Luc Xerri, Stephen M Ansell, Lucile Baseggio, Cécile Reyes, Karin Tarte, Sandrine Boyault, Corinne Haioun, Brian K Link, Pierre Feugier, Armando Lopez-Guillermo, Hervé Tilly, Pauline Brice, Sandrine Hayette, Fabrice Jardin, Fritz Offner, Pierre Sujobert, David Gentien, Alain Viari, Elias Campo, James R Cerhan, Gilles Salles
Journal: The Lancet Oncology (2018)
CAMKs support development of acute myeloid leukemia
Authors: Xunlei Kang, Changhao Cui, Chen Wang, Guojin Wu, Heyu Chen, Zhigang Lu, Xiaoli Chen, Li Wang, Jie Huang, Huimin Geng, Meng Zhao, Zhengshan Chen, Markus Müschen, Huan-You Wang, Cheng Cheng Zhang
Journal: Journal of Hematology & Oncology (2018)

We recently identified the human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse ortholog-paired Ig-like receptor (PirB) as receptors for several angiopoietin-like proteins (Angptls). We also demonstrated that PirB is important for the development of acute myeloid leukemia (AML), but exactly how an inhibitory receptor such as PirB can support cancer development is intriguing. Here, we showed that the activation of Ca (2+)/calmodulin-dependent protein kinases (CAMKs) is coupled with PirB signaling in AML cells. High expression of CAMKs is associated with a poor overall survival probability in patients with AML. Knockdown of CAMKI or CAMKIV decreased human acute leukemia development in vitro and in vivo. Mouse AML cells that are defective in PirB signaling had decreased activation of CAMKs, and the forced expression of CAMK partially rescued the PirB-defective phenotype in the MLL-AF9 AML mouse model. The inhibition of CAMK kinase activity or deletion of CAMKIV significantly slowed AML development and decreased the AML stem cell activity. We also found that CAMKIV acts through the phosphorylation of one of its well-known target (CREB) in AML cells. CAMKs are essential for the growth of human and mouse AML. The inhibition of CAMK signaling may become an effective strategy for treating leukemia.
David Oliver: Should NHS doctors work in unsafe conditions?
Authors: David Oliver
Journal: BMJ (2018)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following David Oliver: Should NHS doctors work in unsafe conditions? Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Traitement endoscopique des gros calculs et/ou des empierrements cholédociens
Authors: I Ghribi, B Ben Slimane, K Boughoula, M Ghanem, S Bizid, AH Ben, MR Bouali, N Abdelli
Journal: Endoscopy (2018)

La sphinctérotomie biliaire endoscopique (SE) est une option thérapeutique de choix dans la prise en charge de la lithiase de la voie biliaire principale (LVBP), permettant d'obtenir une clairance complète dans plus de 90% des cas. Cependant, la présence d'un gros calcul ou d'un empierrement cholédocien peut en limiter ses résultats. Le but de ce travail était d'évaluer le taux de succès, les complications ainsi que les facteurs influençant le traitement endoscopique en cas de gros calculs et/ou d'empierrement cholédociens.
Knowing when to quit
Authors: Rebecca Coombes
Journal: BMJ (2018)

A research article in The BMJ this week contains a useful message to readers helping patients who are making new year attempts to stop smoking. The risk of developing cardiovascular disease even if patients smoke just one cigarette a day is higher than expected—as much as half the risk of smoking 20 a day—the paper finds (doi:10.1136/bmj.j5855).

The researchers, from University College London, analysed 141 studies to estimate the relative risks of smoking one, five, or 20 cigarettes a day. They found that men who smoked …
The Role of Adjuvant 1.25-Dihidroxyvitamin D3 on CD4 + CD25 + CD127 low Regulatory T-cell in Subcutaneous Allergen Specific Immunotherapy
Authors: Melati Sudiro, Teti Madiadipoera, Thaufiq Siddiq Boesoirie, Budi Setiabudiawan
Journal: Journal of Allergy and Clinical Immunology (2018)
The Evolving Landscape of Brain Metastasis
Authors: Manuel Valiente, Manmeet S. Ahluwalia, Adrienne Boire, Priscilla K. Brastianos, Sarah B. Goldberg, Eudocia Q. Lee, Emilie Le Rhun, Matthias Preusser, Frank Winkler, Riccardo Soffietti
Journal: Trends in cancer (2018)
The risk of cardiovascular events in psoriasis patients treated with tumor necrosis factor–α inhibitors versus phototherapy: An observational cohort study
Authors: Jashin J. Wu, Murali Sundaram, Martin Cloutier, Marjolaine Gauthier-Loiselle, Annie Guérin, Rakesh Singh, Arijit Ganguli
Journal: Journal of the American Academy of Dermatology (2018)
Mucosectomies des lésions de 10 à 25 mm: l'ancrage de la pointe de l'anse permet il d'améliorer la qualité des résections endoscopiques?
Authors: M Pioche, J Jacques, V Lepilliez, T Wallenhorst, H Lepetit, R Legros, F Rostain, L Bianchi, JC Saurin, T Ponchon, J Rivory
Journal: Endoscopy (2018)

La mucosectomie est la technique de référence pour la résection des lésions néoplasiques colorectales entre 10 et 25 mm. L'objectif d'une résection endoscopique est d'enlever la totalité du tissu néoplasique (résection complète) et si possible en un seul morceau (En Bloc) avec une marge de sécurité (résection R0). L'ancrage de l'anse consiste à faire une incision ponctuelle de la muqueuse normale à distance de la lésion pour fixer la pointe de l'anse et l'empêcher de glisser près des berges lésionnelles. Cette technique n'utilise aucun matériel supplémentaire par rapport à une mucosectomie standard. Cette première étude vise à évaluer la qualité de résection obtenue (résections En Bloc et R0) grâce à cet ancrage de l'anse systématique et de vérifier sa sécurité.
SUZ12 overexpression in human tumors is associated with tumoral transformation and its depletion affects Mantle cell lymphoma cell lines viability.
Authors: Daniel Martin-Perez, Esther Sanchez, Lorena Maestre, Miguel Angel Piris, Margarita Sanchez-Beato
Journal: Cancer Research (2007)

375  Polycomb Group (PcG) members are known transcriptional repressors with an important function in development by means of the control of HOX genes expression. PcG proteins exert its function by forming DNA-binding repressive complexes that are able to change chromatin structure through epigenetic mechanisms. Many studies suggest a role for PcG members in stem cell self-renewal and cell fate decisions. Recent studies have demonstrated the importance of certain PcG proteins in several types of human tumour. For instance BMI1 is involved in lymphomagenesis and other tumours; EZH2 has a role in prostate cancer progression and in neoplastic transformation of breast epithelial cells and SUZ12 mRNA has been found to be up-regulated in a number of different human tumours, including tumours of the colon and breast. We have studied the expression of EZH2 and SUZ12 in non-tumoral (154 samples) and tumoral (550 samples) human tumours by using tissue microarrays. Although these two proteins form part of the same complex, EZH2 was ubiquitously expressed in every normal and tumoral tissue while SUZ12 was selectively expressed in germ cells, proliferating cells (germinal centre cells) in lymph nodes and in epithelial cells of different tissues. SUZ12 protein is also over represented in some tumours in contrast with the normal counterpart. Among these tumours we have found colonic adenomas, lung neuroendocrine small-cell carcinoma, melanoma and mantle cell lymphoma (MCL). MCL patients that overexpress SUZ12 show a shorter survival than patients that do not overexpress this protein. To address the function of SUZ12 in MCL we have performed functional RNAi-based assays against this gene. We have infected Jeko1 and Z138 MCL cell lines with lentivirus carrying either two different shRNAs against SUZ12 or a scramble oligo using GFP as a marker. After successful knock-down, GFP positive cells showed a competitive disadvantage when infected with the SUZ12 silencing oligos compared with GFP negative cells while GFP positive cells in the scramble control had the same behaviour as non-infected cells. After 8 passages the percentage of GFP positive cells was reduced around 50% in the silenced cells and the remaining GFP positive cells did not show repression of SUZ12, suggesting that the effect of the depletion of SUZ12 is stronger than the effect measured by the competition assay. Results of Gene Expression Profile comparing control cells versus SUZ12 deficient cells will be discussed in the poster.
New Insights Into the Role of mTOR Signaling in the Cardiovascular System
Authors: Sebastiano Sciarretta, Maurizio Forte, Giacomo Frati, Junichi Sadoshima
Journal: Circulation Research (2018)

The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form 2 multiprotein complexes, called mTORC1 (mTOR complex 1) and mTORC2 (mTOR complex 2). In the cardiovascular system, the mTOR pathway regulates both physiological and pathological processes in the heart. It is needed for embryonic cardiovascular development and for maintaining cardiac homeostasis in postnatal life. Studies involving mTOR loss-of-function models revealed that mTORC1 activation is indispensable for the development of adaptive cardiac hypertrophy in response to mechanical overload. mTORC2 is also required for normal cardiac physiology and ensures cardiomyocyte survival in response to pressure overload. However, partial genetic or pharmacological inhibition of mTORC1 reduces cardiac remodeling and heart failure in response to pressure overload and chronic myocardial infarction. In addition, mTORC1 blockade reduces cardiac derangements induced by genetic and metabolic disorders and has been reported to extend life span in mice. These studies suggest that pharmacological targeting of mTOR may represent a therapeutic strategy to confer cardioprotection, although clinical evidence in support of this notion is still scarce. This review summarizes and discusses the new evidence on the pathophysiological role of mTOR signaling in the cardiovascular system.
Survie sans récidive à 3 ans et survie globale à 5 ans de la pose de prothese colique métallique auto-expansive en pont vers la chirurgie. Etude prospective monocentrique
Authors: F Heluwaert, L Renaud, L Tracanelli, M Abousalihac, A Montchaud, E Thimonier, I Lienhart, J Pofelski, M Baconnier, E Maillard, P Capony
Journal: Endoscopy (2018)

Les prothèses coliques métalliques auto-expansives sont un traitement efficace pour la levée du syndrome occlusif colique d'origine carcinologique. Son utilisation dans un cadre curatif, en «pont» vers la chirurgie est l'objet de désaccord quant au bénéfice fonctionnel par rapport au risque carcinologique potentiel. Les recommandations de la SFED, de l'ESGE considère son utilisation comme une option dan les centres experts. Cependant des grandes études internationales récentes semblent montrer que malgré un risque de récidive plus important, le pronostic à long terme reste similaire à la réalisation d'une chirurgie en urgence (1,2).
Recent Trends in Fatalities, Waiting Times, and Use of Epinephrine Auto-Injectors for Subcutaneous Allergen Immunotherapy (SCIT): AAAAI/ACAAI National Surveillance Study 2008-2016
Authors: Tolly Epstein, Gary M. Liss, Karen J. Murphy-Berendts, David I. Bernstein
Journal: Journal of Allergy and Clinical Immunology (2018)
Patent Medicines: A Good Suggestion.
Authors: J. E. Miller
Journal: JAMA (1905)

Rogersville, Tenn., Sept. 13, 1905. <h3>To the Editor:</h3> —Under separate cover I am to-day mailing you a marked copy of the<i>Rogersville Review</i>, a weekly newspaper published in this, a town of about 3,000 inhabitants. I have had the editor copy your editorial<sup>1</sup>of September 2 on the patent medicine fraud as it prevails in the United States with special reference to peruna. These little weekly papers circulate among the rural people, where every issue is read through, ads and all alike. I would suggest that you induce every member of the American Medical Association to have this or some like article occasionally brought out in his home paper. Surely all the physicians of a town would have sufficient influence with their local paper to do this. I assure you that it would work wonders. The people at large have never heard anything but praise of these nostrums, and
Morbi-mortalité liée à la gastrostomie endoscopique percutanée: Prévalence et facteurs prédictifs, à travers une série de 95 cas
Authors: N Elleuch, W Dahmani, M Ksiaa, H Jaziri, A Hammami, A Braham, S Ajmi, A Ben Slama, A Jmaa
Journal: Endoscopy (2018)

La gastrostomie endoscopique percutanée (GPE) représente actuellement une méthode de choix d'assistance nutritionnelle à moyen ou à long terme. Il s'agit certes d'une méthode facile, rapide et économique mais, qui reste tout de même non dénuée de risques.
Death and suffering in Eastern Ghouta, Syria: a call for action to protect civilians and health care
Authors: Samer Jabbour, Fouad M Fouad, Jennifer Leaning, Donna McKay, Rabie Nasser, Leonard S Rubenstein, Annie Sparrow, Paul Spiegel, Ahmad Tarakji, Ronald Waldman, Rola Hallam, Denis Mukwege, Ghanem Tayara
Journal: The Lancet (2018)
Impact de l'ENDOCUFF sur le taux de detection d'adenomes colorectaux: meta-analyse d'essais randomises
Authors: N Williet, Q Tournier, C Vernet, O Dumas, L Rinaldi, X Roblin, JM Phelip
Journal: Endoscopy (2018)

Le taux de détection d'adénome (TDA) est devenu un critère qualité de l'endoscopie puisqu'il est corrélé au risque de cancer colorectal d'intervalle. L'ENDOCUFF (Norgine) qui est un dispositif médical stérile de Classe I, s'attache à l'extrémité du coloscope et permet d'ouvrir le champ de vision en maintenant écartés les plis du côlon lors du retrait du coloscope. Un nombre croissant d'études randomisées se sont intéressées récemment à cet outil accessible en pratique clinique.
Stable Elevations in FIX Activity and Reductions in Annualized Bleeding Rate over up to 2 Years of Follow-up of Adults with Severe or Moderate-Severe Hemophilia B Treated with AMT-060 (AAV5-hFIX) Gene Therapy
Authors: Frank W.G. Leebeek, K Meijer, Michiel Coppens, Peter Kampmann, R Klamroth, Roger Schutgens, Giancarlo Castaman, Erhard Seifried, J Schwaeble, Halvard Bonig, Eileen K Sawyer, Wolfgang A. Miesbach
Journal: Blood (2017)
Abstract #3487: Single cell analysis of senescent breast carcinoma cells using confocal Raman micro-spectroscopy
Authors: Lindsey Maccoux, Melissa Mariani, Christian Matthäus, Max Diem, Volker Deckert, Jan Hengstler
Journal: Cancer Research (2009)

Oncogenic-ErbB2 induced senescence is considered to be a primary fail-safe mechanism in tumorigenesis of breast cancer. Induction of senescence leads to many structural and metabolic changes as well as cell cycle arrest. Here, we investigate the underlying structural changes at the single cell level of proteins, lipids and nucleic acids in the breast carcinoma cell line MCF7/NeuT using confocal Raman micro-spectroscopy. Compared with other widespread imaging methods, Raman micro-spectroscopy provides the added benefits of label-free sample analysis and chemical information pertinent for specific localities. NeuT, a rat homolog to the human tyrosine kinase receptor ErbB2 was transfected into the MCF7 cell line using a vector based on the Tet-on system to induce senescence upon up-regulation of NeuT by the administration of the antibiotic doxycycline. MCF7/NeuT cells were cultured without (control) and with doxycycline for 7 days on quartz discs and fixed in 2% formaldehyde. This caused a strong up-regulation of NeuT mRNA and protein, cell cycle arrest and an altered cell morphology characterized by granules and larger cell size that was shown to be mediated via P38 and nuclear accumulation of P21. Cell samples were imaged to reveal cellular component organizational profiles using a confocal Raman micro-spectroscopy set-up (WiTec, Germany). A laser wavelength of 514.2nm at c.a. 5mW was combined with a 100x objective (N.A. 0.9) for sample excitation, providing a lateral resolution of 0.5µm per pixel. Unsupervised hierarchical cluster analysis was performed to elucidate sub-cellular components and average cluster spectra were compared. Raman imaging of control and doxycycline-incubated cells suggests distinct changes in lipid organizational profiles along the cell membrane as the cell enters senescence. As a result, confocal Raman micro-spectroscopy has been shown to aid in visualizing the role of senescence in tumorigenesis without the use of labels or elaborate sample preparation methods as well as enable chemical information fluctuations to be assessed throughout cells both prior to and while entering senescence.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3487.
Comorbidities in Autoimmune Skin Diseases
Authors: Dennis Linder, Stefano Piaserico, Mauro Alaibac
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The effect of a family health-team approach on the quality of health care for Palestinian infants in Jordan: a mixed methods study
Authors: Noortje Gerritsma, Maartje-Maria van den Berg, Ali Khader, Majed Hababeh, Loai Farajallah, Ishtaiwi Abu-Zayed, Mohammad Ashraf, Ghada Ballout, Akihiro Seita
Journal: The Lancet (2018)
Cold snare polypectomy of large lesions: One swallow does not a summer make
Authors: Leon Moons
Journal: Endoscopy (2018)

See also: Wide-field piecemeal cold snare polypectomy of large sessile serrated polyps without a submucosal injection is safeEndoscopy 2018; 50(03): 248-252DOI: 10.1055/s-0043-121219
The US Food and Drug Administration’s Approach for Safe Innovation of Medical Devices in Dermatology
Authors: Cynthia J. Chang, Binita S. Ashar, Laura N. Marquart
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Compartment Effect on the Prognostic Significance of MRD Detection in CLL: Impact of Treatment Type and Duration of Follow-up
Authors: Andy C Rawstron, Dena Howard, Lucy McParland, Ruth Mary de Tute, Laura Collett, David Phillips, Anna Chalmers, Abraham Mullasseril Varghese, Talha Munir, Walter M Gregory, Rebecca Bishop, Francesca J Yates, Kristian Brock, Samuel Muñoz-Vicente, Peter Hillmen
Journal: Blood (2016)