tbuckley/cabot-search huggingface dataset:
Nerve Repair: Biomimetic Architectures for Peripheral Nerve Repair: A Review of Biofabrication Strategies (Adv. Healthcare Mater. 8/2018)
Authors: Paul A. Wieringa, Ana Rita Gonçalves de Pinho, Silvestro Micera, Richard J. A. van Wezel, Lorenzo Moroni
Journal: Advanced Healthcare Materials (2018)

Biofabrication strategies have made significant steps toward overcoming the clinical challenges of peripheral nerve repair. Many activities have focused on emulating the structural features of native nerve tissue which promote nerve regeneration, resulting in the development of a variety of fabrication techniques. In article number 1701164, Lorenzo Moroni and co-workers discuss the most relevant approaches, highlight their biomimetic character, and assess performance in achieving nerve repair.
Patient commentary: General practice needs radical reform, not tweaks like consultation caps
Authors: Jennifer Skillen
Journal: BMJ (2018)

My son and I have the connective tissue disorder Ehlers-Danlos syndrome. He also has autism spectrum disorder, and I have hypothyroidism and osteoarthritis. So we’re both frequent users of primary care.

Our surgery has responded to the national shortage of GPs by introducing what patients call “double triage” when we phone to make an appointment. First we are triaged by the receptionist and then we wait at home for the GP to phone us.

Sometimes only a face-to-face appointment is suitable—a GP can’t feel or hear the crepitus in my joints or see how swollen and red they are on the phone—and double triage seems to have helped me to see a GP more quickly. It may decrease the number of face-to-face appointments for the GPs, but it hasn’t decreased the overall …
Endoscopic submucosal dissection of a giant esophageal lymphangioma
Authors: Luli Hu, Kuang-I Fu, Biguang Tuo, Lianjun Di, Xuemei Liu, Kui Zhao, Huichao Wu
Journal: Endoscopy (2018)

Lymphangioma of the esophagus is an exceedingly rare submucosal benign tumor [1]. Only 23 cases have been reported since 1934, and most of the tumors are smaller than 2 cm in diameter. Herein, we present the first report of a giant esophageal lymphangioma (16 × 6 × 4 cm), which was completely and safely resected by endoscopic submucosal dissection (ESD).
EULAR recommendations for the health professional’s approach to pain management in inflammatory arthritis and osteoarthritis
Authors: Rinie Geenen, Cécile L Overman, Robin Christensen, Pernilla Åsenlöf, Susana Capela, Karen L Huisinga, Mai Elin P Husebø, Albère J A Köke, Zoe Paskins, Irene A Pitsillidou, Carine Savel, Judith Austin, Afton L Hassett, Guy Severijns, Michaela Stoffer-Marx, Johan W S Vlaeyen, César Fernández-de-las-Peñas, Sarah J Ryan, Stefan Bergman
Journal: Annals of the Rheumatic Diseases (2018)

Pain is the predominant symptom for people with inflammatory arthritis (IA) and osteoarthritis (OA) mandating the development of evidence-based recommendations for the health professional's approach to pain management. A multidisciplinary task force including professionals and patient representatives conducted a systematic literature review of systematic reviews to evaluate evidence regarding effects on pain of multiple treatment modalities. Overarching principles and recommendations regarding assessment and pain treatment were specified on the basis of reviewed evidence and expert opinion. From 2914 review studies initially identified, 186 met inclusion criteria. The task force emphasised the importance for the health professional to adopt a patient-centred framework within a biopsychosocial perspective, to have sufficient knowledge of IA and OA pathogenesis, and to be able to differentiate localised and generalised pain. Treatment is guided by scientific evidence and the assessment of patient needs, preferences and priorities; pain characteristics; previous and ongoing pain treatments; inflammation and joint damage; and psychological and other pain-related factors. Pain treatment options typically include education complemented by physical activity and exercise, orthotics, psychological and social interventions, sleep hygiene education, weight management, pharmacological and joint-specific treatment options, or interdisciplinary pain management. Effects on pain were most uniformly positive for physical activity and exercise interventions, and for psychological interventions. Effects on pain for educational interventions, orthotics, weight management and multidisciplinary treatment were shown for particular disease groups. Underpinned by available systematic reviews and meta-analyses, these recommendations enable health professionals to provide knowledgeable pain-management support for people with IA and OA.
Author Correction: Circuit dissection of the role of somatostatin in itch and pain
Authors: Jing Huang, Erika Polgár, Hans Jürgen Solinski, Santosh K. Mishra, Pang-Yen Tseng, Noboru Iwagaki, Kieran A. Boyle, Allen C. Dickie, Mette C. Kriegbaum, Hendrik Wildner, Hanns Ulrich Zeilhofer, Masahiko Watanabe, John S. Riddell, Andrew J. Todd, Mark A. Hoon
Journal: Nature Neuroscience (2018)
Problems and Practices in a Community Hospital
Authors: F. Richard Pierce, Trento J. Domenici
Journal: New England Journal of Medicine (1950)

AT THE Henry Heywood Memorial, a 120-bed L general hospital, during 1947–1948 there were 8129 admissions. Among these were 60 cases of diagnosed venous thrombosis, or approximately 1 case in each 135 admissions. Since this type of hospital cares for about half the general patients in this state,1 the problem of treating venous thrombosis must be faced here as surely as in the large teaching centers.At present, the proper method of treating venous thrombosis is controversial. The literature on the subject in the past five years is prima-facie evidence of this statement. The physician who is faced with the . . .
Outcome of liver grafts procured from hepatitis C-positive donors in the era of direct-acting antiviral drugs: a preliminary single centre experience
Authors: S. Martini, F. Calvo, C. Chialà, F. Tandoi, S. Mirabella, A. Ottobrelli, A. Amoroso, M. Salizzoni, G.M. Saracco, R. Romagnoli
Journal: Journal of Hepatology (2018)
A merged protocol of hypothermic oxygenated machine perfusion and normothermic machine perfusion optimizes the reconditioning of marginal donor livers
Authors: Y. Boteon, A. Schlegel, R. Laing, L. Wallace, A. Smith, J. Attard, D. Neil, T. Perera, D.F. Mirza, J. Isaac, P. Muiesan, S. Afford, H. Mergental
Journal: Journal of Hepatology (2018)
Occurrence and characteristics of hospitalizations during first-line chemotherapy among individuals with metastatic colorectal cancer.
Authors: Michael Jordan Fisch, Michael Grabner, Daniel S Mytelka, Amit D Raval, Lee Bowman, David M Kern, Collin Churchill, Joseph Singer, Stewart Wetmore, John Barron, Michael Eleff
Journal: Journal of Clinical Oncology (2018)

691 Background: Choosing chemotherapy for metastatic colorectal cancer (mCRC) requires balancing clinical effectiveness and risk of complications. This study characterized real-world inpatient/ER hospitalizations (HOSP) during first-line chemotherapy among individuals with mCRC. Methods: We conducted a retrospective cohort study of adults with mCRC identified using claims data from the HealthCore Integrated Research Environment as initiating first-line chemotherapy from 12/23/2013 to 06/30/2016 (no minimum follow-up). Cohorts were analyzed in aggregate and for the most frequently observed first-line agents (5 overlapping subcohorts). HOSPs were identified from initiation of first-line chemotherapy to 30 days after the end of first-line chemotherapy or last available data. Results: A total of 717 individuals (mean age 55y; 58% male; 44%/39%/6%/12% with ECOG = 0/1/2+/missing; median follow-up 116 days) met study criteria. Metastasis was most commonly to the liver (51%) and 53% of patients had cancer-attributable morbidities. Chemotherapies included 5-FU (79%), oxaliplatin (67%), bevacizumab (58%), irinotecan (21%), and capecitabine (19%). Overall, 40% of patients had ≥1 HOSP [n = 285; total 415 events], ranging from 38% to 49% across the 5 chemotherapy-based subcohorts; 12% (n = 85) had &gt; 1 HOSP. The median time to first HOSP for patients with an event was 52 days. The median length of inpatient stays was 4 days; Infections/neutropenia (21%), bowel-related complications (17%), cardiac and circulatory disorders (9%), malnutrition (5%), pain (5%) and renal disease (2%) were the most common issues associated with inpatient HOSPs. An increase in HOSPs was observed with worsening ECOG status: 0 (34%), 1 (46%), and 2+ (65%). In regression analyses, ECOG≥1 was associated with a 64%-72% increase (p &lt; 0.01) in the odds of HOSPs compared to patients with ECOG = 0. Conclusions: Approximately 40% of mCRC patients had hospitalizations during the study period. Hospital stays were typically short and associated with infections, neutropenia, or bowel-related complications. Further research is needed to determine how many of these hospitalizations may be avoidable.
Real-world rates of hepatitis B surface antigen seroclearance in patients with chronic hepatitis B: a systematic review, conventional aggregated data meta-analysis and individual patient data meta-analysis
Authors: Y.H. Yeo, H.J. Ho, H.-I. Yang, T.-C. Tseng, M.-S. Kwak, Y.M. Park, Y.Y.J. Fung, M.B. Ferret, M. Rodríguez, C.M. Preda, T. Ungtrakul, P. Charatcharoenwitthaya, X. Li, M. Huan Le, B. Wei, B. Zou, A. Le, D. Jeong, N. Chien, L. Kam, T. Hosaka, M.R. Barciela, F. Suzuki, M. Kobayashi, T. Sriprayoon, Y. Chong, T. Tanwandee, M.-F. Yuen, H.-S. Lee, J.-H. Kao, A. Lok, C.-Y. Wu, M. Nguyen
Journal: Journal of Hepatology (2018)
Metabolically unhealthy status impacts on the risk of significant liver injury in biopsy-proven NAFLD patients beyond obesity
Authors: J. Ampuero, R. Aller, R. Gallego-Durán, J. Banales, J. Crespo, N. Mora-Cuadrado, C. Garcia-Monzon, M.J. Pareja, E. Vilar-Gomez, R. Jiménez-Agüero, J. Caballería, M.T.A. Loste, D. Escudero-García, J. Gómez-Camarero, J.L.C. Panero, D.A. De Luis Román, Á. Gónzalez-Rodriguez, M. Latorre, A. Albillos, V. Aguilar-Urbano, J. Salmerón, J.L. Olcoz-Goñi, P. Aspichueta, Á. Santos-Laso, O.L. Iacono, P. Iruzubieta, I. Graupera, M. García-Torres, E. Badia-Aranda, J.A. Guerra, R. Francés, H. Pastor, E.D. Pozo-Maroto, M. Diago, R. Martin-Mateos, S. Benlloch, C. Fernández-Rodríguez, F.J.G.-S. Rey, P. Estevez, R.J. Andrade, J. Turnés, M.R. Gomez
Journal: Journal of Hepatology (2018)
Dutch hospital makes own drug for rare condition after manufacturer hikes price to €170 000
Authors: Tony Sheldon
Journal: BMJ (2018)

A hospital in Amsterdam has begun producing its own cost price version of the orphan medicine Chenodeoxycholic acid Leadiant (CDCA), a primary bile acid used in treating a rare hereditary metabolic disorder, cerebrotendinous xanthomatosis (CTX), after the manufacturer hiked up the price more than fivefold.

This price increase came after the European Medicines Agency approved the drug’s market authorisation with an indication for CTX (EMA/241528/2017).

Last month Dutch health insurers stopped reimbursing the cost of the drug after Leadiant Biosciences decided to increase the price from €30 000 (£26 450; $35 800) per patient per year to around €170 000. Instead, the pharmacy at Amsterdam’s Academic Medical Center used raw materials imported from China to produce capsules of chenodeoxycholic acid as …
Anemia in the Elderly
Authors: Domenico Girelli, Giacomo Marchi, Clara Camaschella
Journal: HemaSphere (2018)

Abstract Anemia affects a substantial fraction of the elderly population, representing a public health problem that is predicted to further increase in coming years because of the demographic drive. Being typically mild, it is falsely perceived as a minor problem, particularly in the elderly with multimorbidity, so that it often remains unrecognized and untreated. Indeed, mounting evidence indicates that anemia in the elderly (AE) is independently associated with disability and other major negative outcomes, including mortality. AE is generally multifactorial, but initial studies suggested that etiology remains unexplained in near one‐third of cases. This proportion is consistently declining due to recent advances highlighting the role of several conditions including clonal hematopoiesis, “inflammaging,” correctable androgen deficiency in men, and under‐recognized iron deficiency. Starting from a real‐world case vignette illustrating a paradigmatic example of anemia in an elderly patient with multimorbidity, we review the main clinical and pathophysiological aspect of AE, giving some practical insights into how to manage similar cases.
Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis
Authors: M.A. McAleer, I. Jakasa, N. Raj, C.P.F. O'Donnell, M.E. Lane, A.V. Rawlings, R. Voegeli, W.H.I. McLean, S. Kezic, A.D. Irvine
Journal: British Journal of Dermatology (2018)

Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products [natural moisturizing factors (NMFs)], activities of filaggrin-processing enzymes [bleomycin hydrolase (BH) and calpain-1 (C-1)] and plasmin, and corneocyte envelope (CE) maturity in early life are largely unknown.We conducted a cross-sectional, observational study investigating regional and age-dependent variations in NMF levels, activity of proteases and CE maturity in stratum corneum (SC) from infants to determine whether these factors could explain the observed predilection sites for AD in early life.We measured NMF using a tape-stripping method at seven sites in the SC of 129 children (aged < 12 months to 72 months) and in three sites in 56 neonates and infants (< 48 h to 3 months). In 37 of these neonates and infants, corneocyte size, maturity, BH, C-1 and plasmin activities were determined.NMF levels are low at birth and increase with age. Cheek SC, compared with elbow flexure and nasal tip, has the lowest NMF in the first year of life and is the slowest to reach stable levels. Cheek corneocytes remain immature. Plasmin, BH and C-1 activities are all elevated by 1 month of age in exposed cheek skin, but not in elbow skin.Regional and temporal differences in NMF levels, CE maturity and protease activities may explain the predilection for AD to affect the cheeks initially and are supportive of this site as key for allergen priming in early childhood. These observations will help design early intervention and treatment strategies for AD.
Optimal institution of azathioprine maintenance therapy in autoimmune hepatitis: a multicenter cohort study
Authors: S. Pape, T. Gevers, I. Mustafajev, F. van den Brand, K. van Nieuwkerk, G. Bouma, J.M. Vrolijk, B.V. Hoek, J. Hartl, A. Lohse, C. Schramm, G.W. Wong, M. Heneghan, J.P. Drenth
Journal: Journal of Hepatology (2018)
Abstract 4651: Local Bipolar Electrogram-Based Criteria to Evaluate the Transmurality of the Atrial Ablation Lesion
Authors: Kiyoshi Otomo, Kikuya Uno, Yoshito Iesaka
Journal: Circulation (2008)

It is important to recognize whether a transmural lesion (TL) was created by ablation in each ablation site during atrial ablation procedures. The local bipolar atrial electrogram (LBAE)-based criteria to diagnose TL formation, however, remain to be established. This study was performed to define LBAE-based criteria for local TL formation. In 13 anesthetized adult porcines, point-by-point radiofrequency energy applications (30W/55°C/30sec) were performed using a conventional 4-mm tip ablation catheter in the atria (right/left3150/91 sites) during sinus rhythm. After the ablation procedure, the hearts were extracted and the ablation lesions were macroscopically identified. The hearts were fixed with formalin, and each section (0.5 mm interval) was stained with Masson’s trichrome stain and examined under light microscopy. Histopathological examination revealed TLs in 111 and non-transmural lesions (NTLs) in the remaining 130 sites. The LBAEs recorded from the TLs exhibited predominant attenuation in the positive deflection with a morphological change to the QS, Qr or rS pattern, while those recorded from the NTLs exhibited the RS or QR pattern without an abbreviation of the positive deflection (ratio of the amplitude of the positive (Ap) and negative deflection (An) after ablation (=Ap/An) in the TL vs NTL: 0.2±0.3 vs 0.9±1.0; P&lt;0.0001, the Ap after ablation in the TL vs NTL: 0.07±0.6 mV vs 0.5±0.4 mV; P &lt;0.0001). The percent reduction in the Ap (Rp), An (Rn) and total amplitude (Rt) after ablation was significantly larger in the TLs than in the NTLs (Rp:94±6% vs 48±30%; P&lt;0.0001, Rn: 25±48% vs 14±41%; P=0.04, Rt:65±24% vs 35±25%; P&lt;0.0001). A cut-off value of Rp≥80% best discriminated the TL from the NTL with a sensitivity, specificity and positive and negative predictive values of 100%, 85%, 84% and 100%, respectively. The cut-off value of the Rp≥80% with the morphological change of the LBAE to the QS, Qr or rS pattern could discriminate the TLs from the NTLs with high accuracy. This criterion can be one of the practical endpoints for energy delivery at each ablation site during ablation procedures.
Comment on Pareek et al. Enhanced Predictive Capability of a 1-Hour Oral Glucose Tolerance Test: A Prospective Population-Based Cohort Study. Diabetes Care 2018;41:171–177
Authors: Lois Jovanovič
Journal: Diabetes Care (2018)

In a recent article in Diabetes Care , Pareek et al. (1) described a strong predictive power for 1-h postload glucose values. This observation is well known to be true in the case of diabetes and pregnancy. In our original article (2), the results of the glucose diaries of 322 women with type 1 diabetes who performed 8–10 self-monitored blood glucose tests per day for at least 14 days before conception, throughout pregnancy including labor and delivery, and 1 month postpartum were analyzed. …
Plasma proteomics identifies a ‘chemokine storm’ in idiopathic multicentric Castleman disease
Authors: Sheila K. Pierson, Aaron J. Stonestrom, Dustin Shilling, Jason Ruth, Christopher S. Nabel, Amrit Singh, Yue Ren, Katie Stone, Hongzhe Li, Frits van Rhee, David C. Fajgenbaum
Journal: American Journal of Hematology (2018)

Human Herpesvirus‐8 (HHV‐8)‐negative/idiopathic multicentric Castleman disease (iMCD) is a poorly understood disease involving polyclonal lymphoproliferation with dysmorphic germinal centers, constitutional symptoms, and multi‐organ failure. Patients can experience thrombocytopenia, anasarca, reticulin fibrosis, renal dysfunction, organomegaly, and normal immunoglobulin levels, – iMCD‐TAFRO. Others experience thrombocytosis, milder effusions, and hypergammaglobulinemia, –iMCD‐Not Otherwise Specified (iMCD‐NOS). Though the etiology is unknown in both subtypes, iMCD symptoms and disease progression are believed to be driven by a cytokine storm, often including interleukin‐6 (IL‐6). However, approximately two‐thirds of patients do not respond to anti‐IL‐6 therapy; alternative drivers and signaling pathways are not known for anti‐IL‐6 nonresponders. To identify potential mediators of iMCD pathogenesis, we quantified 1129 proteins in 13 plasma samples from six iMCD patients during flare and remission. The acute phase reactant NPS‐PLA2 was the only significantly increased protein ( P = .017); chemokines and complement were significantly enriched pathways. Chemokines represented the greatest proportion of upregulated cytokines, suggesting that iMCD involves a chemokine storm. The chemokine CXCL13, which is essential in homing B cells to germinal centers, was the most upregulated cytokine across all patients (log2 fold‐change = 3.22). Expression of CXCL13 was also significantly increased in iMCD lymph node germinal centers compared to controls in a stromal meshwork pattern. We observed distinct proteomic profiles between the two iMCD‐TAFRO patients, who both failed anti‐IL‐6‐therapy, and the four iMCD‐NOS patients, in whom all three treated with anti‐IL‐6‐therapy responded, suggesting that differing mechanisms may exist. This study reveals proteomic differences between flare and remission and the potential to molecularly define iMCD subgroups.
Still Life Without Skull
Authors: Suzanne Edison
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
like a winter freeze
Authors: D.A. Frater
Journal: Annals of Internal Medicine (2018)

Ad Libitum17 April 2018like a winter freezeD.A. Frater, MDD.A. Frater, MDDallas, Texas (D.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M17-2470 Audio Reading - “like a winter freeze” Audio. Virginia L. Hood, MD, Annals Associate Editor, reads "like a winter freeze," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The stones are stainedwith the dark spotof fires whose smokebrought by winter rainweeps upon thecemetery's bonesodd spires tilt abovethe unsettled earthslabs of tombs stonesround like the domeof the sky theirinscriptions wornby the touch ofunseen mourners walkingas if in spirit upon therest of the deadLike a winter freezethe trees stopped rustlingripples crossing the waterdrowned warmth risingleft the earth thesky emptied from surfacethe cold boringdown until the drumbeatstopped until we calledyou dead and unseenfeathers were preened Author, Article, and Disclosure InformationAffiliations: Dallas, Texas (D.F.)Current Author Address: D.A. Frater, MD; e-mail, [email protected]md. PreviousarticleNextarticle Advertisement Audio Reading - “like a winter freeze” Audio. Virginia L. Hood, MD, Annals Associate Editor, reads "like a winter freeze," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 17 April 2018Volume 168, Issue 8Page: 600KeywordsBoneTouchWalking ePublished: 17 April 2018 Issue Published: 17 April 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The postoperative serumcourse of the liver regeneration-associated signaling molecules bile salts and FGF19 in cholestatic patients undergoing liver resection
Authors: K. Koelfat, K. van Mierlo, M. Schmeding, T. Cramer, I. Sauer, C. Dejong, F. Schaap, U. Neumann, S.O. Damink
Journal: Journal of Hepatology (2018)