tbuckley/cabot-search huggingface dataset:
Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma
Authors: Y.L. Kwong, S.J. Kim, E. Tse, S.Y. Oh, J.Y. Kwak, H.S. Eom, Y.R. Do, Y.C. Mun, S.R. Lee, H.J. Shin, C. Suh, S.S. Chuang, Y.S. Lee, S.T. Lim, K. Izutsu, R. Suzuki, T. Relander, F. d’Amore, N. Schmitz, A. Jaccard, W.S. Kim
Journal: Annals of Oncology (2017)

In stage I/II natural killer (NK)/T-cell lymphoma, concurrent chemoradiotherapy (CCRT) had previously been shown to result in superior outcome compared with anthracycline-containing regimens, which have since been considered ineffective. The role of CCRT in comparison with approaches employing nonanthracycline-containing chemotherapy (CT) and sequential radiotherapy (RT) in such patients remains to be defined.Three hundred and three untreated patients (207 men, 96 women; median age: 51, 18-86 years) with stage I/II NK/T-cell lymphoma who had received nonanthracycline-containing regimens were collected from an international consortium and retrospectively analyzed. Treatment included single modality (CT and RT), sequential modalities (CT + RT; RT + CT) and concurrent modalities (CCRT; CCRT + CT). The impact of clinicopathologic parameters and types of treatment on complete response (CR) rate, progression-free-survival (PFS) and overall-survival (OS) was evaluated.For CR, stage (P = 0.027), prognostic index for NK/T-cell lymphoma (PINK) (P = 0.026) and types of initial treatment (P = 0.011) were significant prognostic factors on multivariate analysis. On Cox regression analysis, ECOG performance score (P = 0.021) and PINK-EBV DNA (PINK-E) (P = 0.002) significantly impacted on PFS; whereas ECOG performance score (P = 0.008) and stage (P < 0.001) significantly impacted on OS. For comparing CCRT ± CT and sequential CT + RT, CCRT ± CT patients (n = 190) were similar to sequential CT + RT patients (n = 54) in all evaluated clinicopathologic parameters except two significantly superior features (higher proportion of undetectable circulating EBV DNA on diagnosis and lower PINK-E scores). Despite more favorable pre-treatment characteristics, CCRT ± CT patients had CR rate, PFS and OS comparable with sequential CT + RT patients on multivariate and Cox regression analyses.In stage I/II NK/T-cell lymphomas, when effective chemotherapeutic regimens were used, CCRT and sequential CT + RT gave similar outcome.
Shape-controlled magnetic mesoporous silica nanoparticles for magnetically-mediated suicide gene therapy of hepatocellular carcinoma
Authors: Zheng Wang, Zhimin Chang, Mengmeng Lu, Dan Shao, Juan Yue, Dian Yang, Xiao Zheng, Mingqiang Li, Kan He, Ming Zhang, Li Chen, Wen-fei Dong
Journal: Biomaterials (2017)
TCT-302 Impact of incomplete revascularization on long-term outcomes following chronic total occlusion percutaneous coronary intervention
Authors: Lorenzo Azzalini, Soledad Ojeda, Joseph Dens, Alessio La Manna, Susanna Benincasa, Barbara Bellini, Luciano Candilio, Francisco Hidalgo, Joren Maeremans, Giacomo Gravina, Eligio Miccichè, Guido D'Agosta, Corrado Tamburino, Manuel Pan, Mauro Carlino, Antonio Colombo
Journal: Journal of the American College of Cardiology (2017)
Abstract 16948: Cholesterol-enriched Macrophages Excrete Cholesterol into Unique Extracellular Deposits
Authors: Xueting Jin, Ying Liu, Chris A Combs, Janet Chang, Neta Varsano, Lia Addadi, Howard S Kruth
Journal: Circulation (2016)

Introduction: Atherosclerotic plaques contain cholesterol in both intracellular and extracellular forms. However, the origin and fate of extracellular cholesterol in atherosclerosis is far less und...
Optimizing Somatostatin Receptor Imaging in Patients With Neuroendocrine Tumors
Authors: Jolanta Kunikowska, Valerie Lewington, Leszek Krolicki
Journal: Clinical Nuclear Medicine (2017)

The presence of somatostatin receptors in neuroendocrine tumors allows visualization with radiolabeled somatostatin analogs in vivo. The aim of this prospective study was to compare somatostatin receptor imaging using Tc-HYNICTOC with Ga-DOTATATE (DOTA-DPhe1,Tyr3-octreotate) with respect to sensitivity, specificity, and impact upon clinical decision making.Sixty-eight patients (30 men, 38 women; aged 56.4 ± 13.5 years) with disseminated, histologically proven neuroendocrine tumor were enrolled. All patients with previous Tc-HYNICTOC (Tektrotyd; POLATOM, Otwock, Poland) underwent Ga-DOTATATE PET/CT. Both examinations were compared on a per-patient and per-lesion basis.The sensitivity, specificity, positive and negative predictive values, and accuracy of Ga-DOTATATE and Tc-HYNICTOC were 100% versus 82%, 85% versus 69%, 97% versus 92%, 100% versus 47%, and 97% versus 79%, respectively.Concordant results were observed in 58 patients (49/68 positive on both Ga-DOTATATE and Tc-HYNICTOC and 9/68 negative in both examinations). Ten of 68 patients had Ga-DOTATATE-positive, Tc-HYNICTOC-negative studies. Two hundred eighteen lesions were detected using Tc-HYNICTOC, compared with 546 lesions using Ga-DOTATATE (P < 0.0001). Ga-DOTATATE detected a higher number of lesions in bone and lymph nodes, liver, intestine, and pancreas and had a higher sensitivity for subcentimeter abnormalities than Tc-HYNICTOC. Ga-DOTATATE led to management change in 23 (34%) of 68 patients.Ga-DOTATATE has a higher sensitivity than Tc-HYNICTOC for the detection of neuroendocrine tumors. Ga-DOTATATE proved superior to Tc-HYNICTOC in detecting subcentimeter skeletal, lymph node, and liver metastases. Ga-DOTATATE PET/CT changed clinical decision making in one third of patients.
Contempt – Where the modularity of the mind meets the modularity of the brain?
Authors: Danilo Bzdok, Leonhard Schilbach
Journal: Behavioral and Brain Sciences (2017)

Abstract “Contempt” is proposed to be a unique aspect of human nature, yet a non-natural kind. Its psychological construct is framed as a sentiment emerging from a stratification of diverse basic emotions and dispositional attitudes. Accordingly, “contempt” might transcend traditional conceptual levels in social psychology, including experience and recognition of emotion, dyadic and group dynamics, context-conditioned attitudes, time-enduring personality structure, and morality. This strikes us as a modern psychological account of a high-level, social-affective cognitive facet that joins forces with recent developments in the social neuroscience by drawing psychological conclusions from brain biology.
Risk factors for asthma after infant bronchiolitis
Authors: S. Törmänen, E. Lauhkonen, R. Riikonen, P. Koponen, H. Huhtala, M. Helminen, M. Korppi, K. Nuolivirta
Journal: Allergy (2017)

Abstract Background Five studies carried out after bronchiolitis at less than 24 months of age, with a follow‐up of more than 10 years, reported that atopic dermatitis, family asthma, early‐life exposure to tobacco smoke and rhinovirus aetiology were early‐life risk factors for later asthma. This study evaluated the long‐term outcome at 11‐13 years of age of children who were hospitalized for bronchiolitis in early infancy. Methods We previously prospectively followed 166 children hospitalized for bronchiolitis at less than 6 months of age until 5‐7 years of age. The current study included a structured questionnaire, parental interviews, clinical examinations and bronchodilation test of 138 of those children at 11‐13 years of age. Results Respiratory syncytial virus caused 66% of the bronchiolitis cases, and nearly half of the patients were exposed to tobacco smoke in early life. Doctor‐diagnosed asthma was present in 13% of the former bronchiolitis patients at 11‐13 years of age. Maternal asthma was the only independently significant risk factor in early life (adjusted OR 3.45, 95% CI 1.07‐11.74), as was allergic rhinitis at 5‐7 years of age (adjusted OR 4.06, 95% CI 1.35‐12.25). Conclusions After bronchiolitis at less than 6 months of age, the risk of doctor‐diagnosed asthma at 11‐13 years was about twice that of the general Finnish population. Maternal asthma was the only independently significant early‐life risk factor for current asthma at 11‐13 years of age.
TCT-782 Effect of a Mechanical-Expanding vs. Self-Expanding Transcatheter Valve Prosthesis on Health Status in Patients with Severe Aortic Stenosis at High Surgical Risk: Results from the REPRISE III Trial
Authors: Suzanne Baron, Haiyan Li, Elizabeth Magnuson, Suzanne Arnold, Christopher Meduri, Raj Makkar, Tanvir Bajwa, Axel Linke, Dean Kereiakes, Ron Waksman, Vinod Thourani, Ian Meredith, Dominic Allocco, Michael J. Reardon, Ted Feldman, David Cohen
Journal: Journal of the American College of Cardiology (2017)
Action of Toxic Doses of the Polysaccharide from &lt;italic&gt;Serratia Marcescens (Bacillus Prodigiosus)&lt;/italic&gt; on the Dog and Guinea Pig
Journal: JNCI Journal of the National Cancer Institute (1944)

Action of Toxic Doses of the Polysaccharide from Serratia Marcescens (Bacillus Prodigiosus) on the Dog and Guinea Pig Get access F. E. Franke F. E. Franke assistant professor of physiology St. Louis University School of Medicine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 5, Issue 3, December 1944, Pages 185–193, https://doi.org/10.1093/jnci/5.3.185 Published: 01 December 1944
Servicio de Investigación Epidémica (EIS) de EE UU
Authors: Stephen M. Ostroff
Journal: Eurosurveillance (2001)

El Servicio de Investigacion Epidemica (Epidemic Intelligence Service; -EIS-) –programa de dos anos de formacion epidemiologica aplicada de los CDC de los Estados Unidos– celebra su 50o aniversario en 2001. Creado durante la guerra de Corea, solo cinco anos despues de la creacion de los CDC, el estimulo que impulso el desarrollo del EIS fue la ausencia de investigadores de campo adecuadamente formados ante un posible uso intencionado de agentes biologicos contra la poblacion norteamericana. Sin embargo, para Alexander Langmuir, director de epidemiologia del CDC y fundador del EIS, estaba claro que sus alumnos realizarian un amplio abanico de actividades y ayudarian a compensar la falta de epidemiologos en los EE UU con sus conocimientos y su experiencia practica de campo necesarios para investigar y controlar brotes de enfermedades de origen natural.
HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33
Authors: Megan Osbourn, Dinesh C. Soares, Francesco Vacca, E. Suzanne Cohen, Ian C. Scott, William F. Gregory, Danielle J. Smyth, Matilda Toivakka, Andrea M. Kemter, Thierry le Bihan, Martin Wear, Dennis Hoving, Kara J. Filbey, James P. Hewitson, Holly Henderson, Andrea Gonzàlez-Cìscar, Claire Errington, Sonja Vermeren, Anne L. Astier, William A. Wallace, Jürgen Schwarze, Alasdair C. Ivens, Rick M. Maizels, Henry J. McSorley
Journal: Immunity (2017)

Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. Here, we identified H. polygyrus Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, containing three predicted complement control protein (CCP) modules. In vivo, recombinant HpARI abrogated IL-33, group 2 innate lymphoid cell (ILC2) and eosinophilic responses to Alternaria allergen administration, and diminished eosinophilic responses to Nippostrongylus brasiliensis, increasing parasite burden. HpARI bound directly to both mouse and human IL-33 (in the cytokine's activated state) and also to nuclear DNA via its N-terminal CCP module pair (CCP1/2), tethering active IL-33 within necrotic cells, preventing its release, and forestalling initiation of type 2 allergic responses. Thus, HpARI employs a novel molecular strategy to suppress type 2 immunity in both infection and allergy.
TCT-636 Multivessel Disease in STEMI patients: A Meta-analysis comparing the timing (index vs. staged) of achieving complete revascularization
Authors: Alexandre Hideo-Kajita, Hector Garcia-Garcia, Kayode Kuku, Solomon Beyene, Viana Azizi, Yael Meirovich, Gebremedhin Melaku, Ahn Bui, Aaphtaab Dheendsa, Echo Brathwaite, Sameer Desale, Michael Lipinski, Ron Waksman
Journal: Journal of the American College of Cardiology (2017)
Image Gallery: Flagellate bullous exanthem in chikungunya
Authors: K. Vinay, U.N. Saikia, S. Dogra
Journal: British Journal of Dermatology (2017)

Funding sources: no external funding. Conflicts of interest: none declared. Dear Editor, A 40‐year‐old male presented with acute‐onset fever, arthralgia and skin rash. Linearly arranged vesicobullous lesions were noted over his trunk, back and arms (Fig. 1a). Symptomatic treatment with paracetamol, diclofenac and emollients was offered. In 2 weeks, the lesions had subsided with flagellate pigmentation (Fig. 1b) and immunoglobulin M antichikungunya antibodies were positive. Although previously restricted to Africa and Asia, chikungunya is increasingly reported from Europe and America. Cutaneous manifestations are common and include freckle‐like (30%), diffuse (9%) and flagellate (1·2%) pigmentation.1 Vesicobullous lesions are rare (2·75%).1 Flagellate eruptions are described with chemotherapeutic drugs (bleomycin), dermatomyositis, adult‐onset Still disease and shiitake dermatitis.2 Linearly arranged vesicobullous rash and/or flagellate pigmentation with febrile arthritis should raise suspicion of chikungunya infection.
TCT-720 Impact of stent underexpansion and tissue patterns on recurrent restenosis after paclitaxel-coated balloon angioplasty for drug-eluting stent restenosis assessed with optical coherence tomography
Authors: Katsuya Miura, Akimune Kuwayama, Masanobu Ohya, Takenobu Shimada, Hidewo Amano, Shunsuke Kubo, Habara Seiji, Hiroyuki Tanaka, Yasushi Fuku
Journal: Journal of the American College of Cardiology (2017)
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior
Authors: Michio Miyajima, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Matteo M Guerrini, Yumi Tsutsui, Mikako Maruya, Alexis Vogelzang, Kenji Chamoto, Kurara Honda, Takatoshi Hikida, Satomi Ito, Hongyan Qin, Rikako Sanuki, Keiichiro Suzuki, Takahisa Furukawa, Yasushi Ishihama, Fumihiko Matsuda, Makoto Suematsu, Tasuku Honjo, Sidonia Fagarasan
Journal: Nature Immunology (2017)
KIR3DL2 expression in cutaneous T-cell lymphomas: expanding the spectrum for KIR3DL2 targeting
Authors: Maxime Battistella, Christophe Leboeuf, Caroline Ram-Wolff, Charlotte Hurabielle, Cécile Bonnafous, Hélène Sicard, Armand Bensussan, Martine Bagot, Anne Janin
Journal: Blood (2017)
Corticosteroids in head injury
Authors: D. Yates
Journal: BMJ (2000)

The global epidemic of head injuries is only just beginning. Currently over a million people die each year from brain injuries, and a similar number are disabled, often with profound effects on the quality of their lives.1 Road crashes account for most of the injuries, and car use is rapidly increasing in many countries. By 2020 road crashes will, it is estimated, have moved from ninth to third in the world ranking of disease burden as measured in disability adjusted life years, and second in developing countries.2 Identifying effective treatments for head injury is thus of global health importance.

Corticosteroids have been used to treat severe head injury for over 30 years, though recently their value has been questioned because of the failure to demonstrate effectiveness in randomised trials.3 Nevertheless, corticosteroids continue to be used widely, albeit inconsistently. Two 1996 British surveys, one of nursing staff in 39 neurosurgical intensive care units and one of medical directors in 44 neurosurgical intensive care units, found that corticosteroids were used to treat head injury in 49% and 14% of units respectively. 4 5

If a treatment as simple and …
TCT-342 Comparative Outcomes of Patients with Adult Congenital Heart Disease Admitted to US hospitals with STEMI
Authors: Divyanshu Mohananey, Pedro Villablanca, Tanush Gupta, Sahil Agrawal, Nirmanmoh Bhatia, Harish Ramakrishna, Sripal Bangalore, Mario Garcia, Binita Shah, Mark Menegus, Anna Bortnick, Deepak Bhatt
Journal: Journal of the American College of Cardiology (2017)
TCT-854 Prospective Evaluation of Feasibility, Safety, and Efficacy of Cocoon Duct Occluder for Transcatheter Closure of Large Patent Ductus Arteriosus: A Single-Centre Study with Short- and Medium-Term Follow-up Results
Authors: Santosh Sinha, Mahmadula Razi, Mukesh Jha, Vikas Mishra, Puneet Aggarwal, Lokendra Rekwal, Anupam Singh
Journal: Journal of the American College of Cardiology (2017)
The clinical response to omalizumab in chronic spontaneous urticaria patients is linked to and predicted by IgE levels and their change
Authors: R. Ertas, K. Ozyurt, M. Atasoy, T. Hawro, M. Maurer
Journal: Allergy (2017)

Omalizumab is an effective and well-tolerated treatment for chronic spontaneous urticaria (CSU). Markers and predictors of response are largely unknown, but needed to optimize omalizumab treatment. Omalizumab targets IgE, and IgE levels may be linked to the effects of treatment. We evaluated whether response rates to treatment with omalizumab in patients with CSU are linked to their baseline IgE levels, their IgE levels after omalizumab treatment, and the ratio of on treatment IgE and baseline IgE levels.Chronic spontaneous urticaria (CSU) patients (n = 113) were treated with omalizumab 300 mg/4 weeks for 12 weeks, when their treatment responses, that is, no, partial, or complete response, were assessed by use of the urticaria activity score, physician and patient visual analog scale, and treatment effectiveness score. Total IgE levels were measured before treatment (bIgE) with omalizumab and 4 weeks thereafter (w4IgE).Nonresponders to omalizumab had significantly lower bIgE levels (17.9, 17.0-55.0 IU/mL) than partial responders (82.0, 46.2-126.5 IU/mL, P = .008) and complete responders (73.7, 19.45-153.8 IU/mL, P = .032). Nonresponders also had lower w4IgE levels and lower ratios of w4IgE/bIgE levels than partial and complete responders (P < .001). Nonresponse to omalizumab was best predicted by patients' w4IgE/bIgE ratios, significantly better than by bIgE levels (P = .016).In CSU, total IgE levels and their change predict the response to treatment with omalizumab. The assessment of pre- and post-treatment IgE levels and their ratio may help to improve the management of CSU in patients who require omalizumab treatment.
TCT-379 Spontaneous Coronary Artery Dissection (SCAD) Is Not a Benign Entity: Analysis of 120 Patients in Brazilian SCAD Registry With a Long-Term Follow-Up
Authors: Jamil Cade, Bárbara Freitas Fiorin, Carolina Pereira, Claudia Alves, David Adlam, Marcelo Franken, Pedro A. Lemos, Adriano Caixeta
Journal: Journal of the American College of Cardiology (2017)
PS04.06 GEOMETRY Mono-1: Phase II, Multicenter Study of MET Inhibitor Capmatinib (INC280) in EGFR wt, MET-dysregulated Advanced NSCLC
Authors: J. Wolf, J. Han, M. Nishio, P. Souquet, L. Paz-Ares, F. De Marinis, T. Seto, M. De Jonge, T.M. Kim, J. Vansteenkiste, D.S.w. Tan, E.B. Garon, H. Groen, M.J. Hochmair, E. Felip, N. Reguart, M. Thomas, T. Overbeck, K. Ohashi, M. Giovannini, R. Yura, A. Joshi, M. Akimov, R. Heist
Journal: Journal of Thoracic Oncology (2017)
Abstract 19470: Biomarkers in Cardiac Arrest: A Systematic Review
Authors: Carl M Karlsson, Ari Moskowitz, Gabrielle Aquino, Alexandra Sanfilippo, Jessica Zhu, Daniel McErlean, Lars W Andersen, Michael Donnino
Journal: Circulation (2016)

Introduction: Post cardiac arrest (CA) patients suffer from a post CA syndrome with a high degree of mortality and neurologic morbidity. As such, the use of biomarkers to identify poor outcomes has...
Données de surveillance du VIH/Sida chez les enfants en Grèce
Authors: G Nikolopoulos, V Konte, A Masgala, E Eleni, A Tsantes, D Paraskeva
Journal: Eurosurveillance (2004)

En Grece, la surveillance du VIH/Sida est realisee par le Centre hellenique de controle des maladies infectieuses (Hellenic Centre for Infectious Diseases Control Centre). Le systeme de declaration des cas de Sida a ete mis en place en 1984, et la declaration des infections a VIH en 1998. Cet article presente une analyse des donnees de surveillance et des tendances des infections a VIH/Sida chez les enfants, y compris les cas identifies avant 1998. 
Le nombre d’enfants contamines par le VIH en Grece est relativement faible atteignant 69 cas cumules en juin 2003, dont 44 (64%) cas par transmission mere-enfant. Depuis le debut de l’epidemie, 33 cas de sida pediatriques ont ete declares, l’infection opportuniste la plus frequente etant une pneumonie a Pneumonocystis carinii.
Comparison Study of PD-L1 Immunohistochemistry Assays with 22C3 and 28-8: Analysis on 147 Surgically Resected NSCLC
Authors: Tomohito Saito, Koji Tsuta, Yuki Takeyasu, Hironori Ryota, Kento Fukumoto, Hiroshi Matsui, Yohei Taniguchi, Hiroaki Yanagimoto, Takashi Yokoi, Takayasu Kurata, Tomohiro Murakawa
Journal: Annals of Oncology (2017)
Progressive Renal Disease Established by Renin-Coding Adeno-Associated Virus–Driven Hypertension in Diverse Diabetic Models
Authors: Shannon M. Harlan, Kathleen M. Heinz-Taheny, John M. Sullivan, Tao Wei, Hana E. Baker, Dianna L. Jaqua, Zhonghua Qi, Martin S. Cramer, Tatiyana L. Shiyanova, Matthew D. Breyer, Josef G. Heuer
Journal: Journal of the American Society of Nephrology (2017)

Progress in research and developing therapeutics to prevent diabetic kidney disease (DKD) is limited by a lack of animal models exhibiting progressive kidney disease. Chronic hypertension, a driving factor of disease progression in human patients, is lacking in most available models of diabetes. We hypothesized that superimposition of hypertension on diabetic mouse models would accelerate DKD. To test this possibility, we induced persistent hypertension in three mouse models of type 1 diabetes and two models of type 2 diabetes by adeno-associated virus delivery of renin (ReninAAV). Compared with LacZAAV-treated counterparts, ReninAAV-treated type 1 diabetic Akita/129 mice exhibited a substantial increase in albumin-to-creatinine ratio (ACR) and serum creatinine level and more severe renal lesions. In type 2 models of diabetes (C57BKLS db/db and BTBR ob/ob mice), compared with LacZAAV, ReninAAV induced significant elevations in ACR and increased the incidence and severity of histopathologic findings, with increased serum creatinine detected only in the ReninAAV-treated db/db mice. The uninephrectomized ReninAAV db/db model was the most progressive model examined and further characterized. In this model, separate treatment of hyperglycemia with rosiglitazone or hypertension with lisinopril partially reduced ACR, consistent with independent contributions of these disorders to renal disease. Microarray analysis and comparison with human DKD showed common pathways affected in human disease and this model. These results identify novel models of progressive DKD that provide researchers with a facile and reliable method to study disease pathogenesis and support the development of therapeutics.
TCT-325 Short-term outcomes and readmission rates after percutaneous coronary intervention and CABG in patients with autoimmune vasculitides
Authors: Katherine Bailey, Aditya Mantha, Esteban Aguayo, Young-Ji Seo, Vishal Dobaria, Yen-Yi Juo, Peyman Benharash, Ramin Ebrahimi
Journal: Journal of the American College of Cardiology (2017)