tbuckley/cabot-search huggingface dataset:
Traitement de l’endobrachy-ésophage avec dysplasie de haut grade ou carcinome in situ par mucosectomie endoscopique circulaire. Résultats chez 21 patients
Authors: M Giovannini, A Guillin, E Bories, CH Pesenti, C Danisi
Journal: Endoscopy (2004)

But: Le but de cette étude est d’évaluer l’efficacité de la mucosectomie endoscopique circulaire (MEC) et présenter notre expérience dans le traitement endoscopique de la dysplasie de haut grade (DHG) ou du cancer intra-épithélial développé sur endobrachy-ésophage (EBO). Patients et Méthodes: Vingt et un patients ont été inclus dans l’étude (11 hommes et 10 femmes) entre janvier 1999 et septembre 2002. La lésion était 12 fois une DHG et 9 fois un carcinome intra-épithélial développé sur EBO. La chirurgie était contre-indiquée pour 16/21 patients (cardiopathie, cirrhose ou insuffisance respiratoire) et 5 patients ont refusé le traitement chirurgical. Une échoendoscopie (EE) a été réalisée dans tous les cas. L’EE pré thérapeutique a classé la lésion us T1N0 dans 19 cas et T0N0 us dans 2 cas. Nous avons employé la technique de mucosectomie après l’injection sous-muqueuse de 10–15 mL de sérum physiologique. Un gastroscope double canal a été utilisé chez 15/21 patients. La MEC a été exécutée en 2 temps. Pendant la première session, la zone d’EBO en DHG ou de carcinome in situ a été enlevée et la moitié de la circonférence de la muqueuse de Barrett. La deuxième circonférence a été enlevée un mois après pour empêcher une sténose ésophagienne. Résultats: Quatre complications ont été notées (19,3%). Il s’agissait 4 fois d’hémorragie toujours contrôlée endoscopiquement par la mise en place de clips. Aucune sténose ésophagienne n’est survenue dans le suivi. La résection endoscopique a été considérée comme complète dans 18/21 des cas (85,7%). Dans 3 cas, l’examen histologique a conclu à une résection partielle. Un patient a été opéré et la pièce opératoire n’a pas montré de tumeur résiduelle et les 2 autres ont été traités par une radio chimiothérapie concomitante. Ces 2 patients étaient vivants avec une EE et des biopsies endoscopiques négatives respectivement 18 et 24 mois plus tard. Deux patients considérés comme ayant eu une résection complète ont présenté une récidive locale qui a été traitée aussi par mucosectomie endoscopique. L’EBO a été remplacé par un épithélium malpighien chez 15/20 patients (75%). Le suivi moyen des patients a été de 18 mois. Conclusion: La MEC est un traitement faisable et efficace de la DHG ou de cancer intra-épithélial développé sur EBO. Aucune sténose ésophagienne n’est survenue dans cette étude. Néanmoins des études seront nécessaires afin de comparer la MEC avec les associations mucosectomie et plasma argon ou mucosectomie et photothérapie dynamique dans le même groupe de patients.
06.15 Naturally processed topoisomerase i peptides presented by dendritic cells identify immunodominant t cell epitopes in systemic sclerosis
Authors: Eleni Tiniakou, Andrea Fava, Tara Gurh, Francesco Boin, Erika Darrah
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Identification of immunodominant T cell epitopes of autoantigens is crucial to understanding the pathogenesis of autoimmune diseases and developing disease-specific diagnostic and therapeutic tools. A subset of patients with systemic sclerosis (SSc) exhibit autoantibodies and CD4+ T cells specific for topoisomerase-I (topo-I), which are quantitatively associated with the presence and severity of lung fibrosis.<sup>1</sup> Mapping of immunodominant topo-1 T cell epitopes has been difficult due to poor sensitivity, high cost of experimental protocols, and has mainly been based on <i>in silico</i> prediction. <h3>Objectives</h3> To develop a new method for mapping immunodominant topo-I T cell epitopes using the natural processing and presentation of HLA-DR-restricted topo-I peptides by monocyte derived dendritic cells (MoDCs) from SSc patients. <h3>Methods</h3> MoDCs from 6 anti-topo-I positive SSc patients were pulsed with whole topo-I protein. Following overnight exposure, immunoprecipitation was performed to isolate HLA-DR/peptide complexes. Peptides were eluted, identified by mass spectrometry, and matched to the known Topo-I sequence. These were then synthesised and used to stimulate peripheral blood mononuclear cells (PBMCs) from these patients in the presence of anti-CD40 antibody. Topo-I-reactive CD4+ T cells were identified by flow cytometry based on activation status (CD40L upregulation). PBMCs from 8 HLA-matched healthy donors and 8 additional randomly selected anti-topo-1-positive patients were stimulated using the same protocol. <h3>Results</h3> Ten different naturally processed topo-I specific peptides were identified by mass spectrometric analysis. The median number of distinct peptides presented by each individual patient was 4 (range 1–8), with 60% being presented by two or more individuals. Interestingly, four out of six patients presented two peptides with contiguous sequences. All topo-I peptides were able to stimulate CD4+ T cells from at least one of the patients tested, and 45% of patients responded to one or both of the contiguous peptides. <h3>Conclusions</h3> Through characterisation of naturally processed topo-1 peptides, we have identified immunodominant topo-1 epitopes capable of stimulating CD4+ T cells from patients with SSc. This method represents a cost-effective and dependable way to identify immunodominant epitopes and can provide novel targets for disease monitoring and eventually, designing peptide-targeted immunotherapy.
HOW IMPORTANT IS KNEE POSITION ON LANDING FOR ANKLE SPRAIN?
Authors: Maria António Castro, Orlando Fernandes, Manuel António Janeira, António VencesBrito
Journal: British Journal of Sports Medicine (2017)

Background In sports ankle sprains are responsible for most of the time lost in practice. In basketball, ankle sprains are not only a main injury but they also have a high tendency of re-injury. There is a special interest in finding risk factors that can be used to predict the ankle sprain occurrence and so prevent it. Joint position when contacting the ground is a main issue. Objective The aim of this study is to examine the knee position on ground contact moment and its relationship with ankle sprain. Design To reproduce the most common mechanism of ankle sprain in basketball players, landing in another player's foot, barefoot athletes with healthy (n=17) and already sprained ankles (n=28) were asked to jump from the floor to an unstable round surface placed 50 cm in front of them while kinematics was recorded using an electromagnetic tracking device with 3 sensors located in each segment of the lower limb and another on a round Freeman board. Setting elite basketball players. Patients (or Participants) 13 females, and 12 males accepted to perform five consecutive jumps in unipodal support. Interventions (or Assessment of Risk Factors) Previous ankle sprain or never sprained ankle. Main Outcome Measurements Knee range of motion on landing. Results At contact knee angles did change significantly with previous ankle sprain. Never sprained subjects showed more knee flexion on contact. When separating results by gender we found that women landed with knees in an even more extension degree. Conclusions Knee position on landing differs from healthy to previous sprained ankles. Previous sprained land in a more extension position and consequently a higher impact energy for lower limb and all the body must be absorbed. This difference is even more important among females.
Prevalence, Predictors, and Clinical Presentation of a Calcified Nodule as Assessed by Optical Coherence Tomography
Authors: Tetsumin Lee, Gary S. Mintz, Mitsuaki Matsumura, Wenbin Zhang, Yang Cao, Eisuke Usui, Yoshihisa Kanaji, Tadashi Murai, Taishi Yonetsu, Tsunekazu Kakuta, Akiko Maehara
Journal: JACC. Cardiovascular imaging (2017)
Dépistage du carcinome épidermoïde de l’ésophage chez les patients à risque:Etude prospective nationale
Authors: J Dubuc, JA Seyrig, JP Barbier, T Barrioz, R Laugier, G Boulay, D Grasset, D Sautereau, D Grigoresco, J Butel, JL Legoux, T Ponchon
Journal: Endoscopy (2004)

Introduction: La prévalence du carcinome épidermoïde de l’ésophage chez les patients (pts) à haut risque et l’intérêt d’une endoscopie haute (EGD) avec coloration par lugol systématique pour améliorer sa détection précoce n’ont pas été évalués de façon prospective sur de grands effectifs de pts. Le but de cette étude prospective était de déterminer si et quand le risque était suffisant pour justifier une campagne de dépistage. Patients et Méthodes: Les critères d’inclusion étaient: absence de symptômes oesophagiens et carcinome épidermoïde de localisation ORL ou trachéo-bronchique ancien ou récent [groupe 1 (gr 1)], ou pancréatite chronique d’origine éthylique (gr 2), ou cirrhose d’origine éthylique (gr 3), ou alcoolo-tabagisme suivi par un Centre d’Hygiène Alimentaire (gr 4). Les pts ayant une contre-indication à la réalisation d’une EGD ou à la réalisation de biopsies (varices oesophagiennes, troubles majeurs de la coagulation) étaient exclus. Une EGD était effectuée selon les modalités suivantes: exploration soigneuse de l’ésophage avant et après coloration par 20 ml de lugol à 2% pulvérisé par l’intermédiaire d’un cathéter spray. La recherche et les biopsies des zones »lugol négatives« étaient faites 2 minutes après la coloration. Résultats: De septembre 2000 à juin 2003, 1 097 pts (944 hommes, âge moyen 54,3 ± 11 ans) ont été inclus dans 45 centres d’endoscopie digestive: 394 pts dans le groupe 1, 76 pts dans le groupe 2, 220 pts dans le groupe 3 et 407 pts dans le groupe 4. Les résultats après coloration sont les suivants (Tableau 1). Avant coloration, ont été mis en évidence 29 carcers, 6 DHG, 3 DBG. Après coloration, ont été trouvés 6 cancers, 4 DHG et 19 DBG supplémentaires. Tous groupes confondus, les prévalences du cancer et de la DHG étaient respectivement de 3,2% et 0,8% versus 2,7% et 0,5% avant coloration. La coloration par lugol ne donnait un avantage statistiquement significatif que si l’on tenait compte de la découverte d’une dysplasie de bas grade ; le nombre de lésions découvertes était alors de 6,1% versus 3,5% (p < 0,001). Conclusion: Seul le groupe des patients avec antécédents de cancer ORL ou trachéobronchique présente un risque suffisant pour justifier la mise à l’étude d’une campagne de dépistage. Par ailleurs, la coloration de la muqueuse oesophagienne par lugol n’a pas permis d’augmenter significativement la sensibilité du dépistage des petits cancers de l’ésophage, mais a permis de sélectionner une population à très haut risque probable, porteuse de dysplasies de bas grade.
Reply to Bora Lee and Jae Heon Kim's Letter to the Editor re: Alan D. Uren, Nikki Cotterill, Christopher Harding, et al. Qualitative Exploration of the Patient Experience of Underactive Bladder. Eur Urol 2017;72:402–7
Authors: Alan D. Uren, Nikki Cotterill, Christopher Harding, Christopher Hillary, Christopher Chapple, Monique Klaver, Dominique Bongaerts, Zalmai Hakimi, Paul Abrams
Journal: European Urology (2017)
The Legacy of the Radium Girls
Authors: David E. Cohen, Randie H. Kim
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Characterization of Cytogenetic Abnormalities in Myelofibrosis and Relationship to Clinical Outcome
Authors: Andrew Kuykendall, Chetasi Talati, Najla H Al Ali, Eric Padron, David Sallman, Jeffrey E. Lancet, Kendra L. Sweet, Alan F. List, Kenneth S. Zuckerman, Rami S. Komrokji
Journal: Blood (2016)
間葉系幹細胞の再生能を調節し,骨格筋再生を強化するための合成ニッチ【Powered by NICT】
Authors: Pumberger Matthias, H Qazi Taimoor, Ehrentraut M. Christine, Textor Martin, Kueper Janina, Stoltenburg-Didinger Gisela, Winkler Tobias, von Roth Philipp, Reinke Simon, Borselli Cristina, Perka Carsten, J Mooney David, N Duda Georg, Geissler Sven
Journal: Biomaterials (2016)
Abstract 19336: Reported Stroke Rates in Patients With Nonvalvular Atrial Fibrillation in North America are Lower Than Those Cited in ESC and AHA Guidelines
Authors: Gene R Quinn, Daniel E Singer
Journal: Circulation (2015)

Background: Anticoagulants (OAC) decrease ischemic stroke rates in patients with atrial fibrillation (AF) but increase the risk of bleeding. The risk of ischemic stroke where the absolute benefit of anticoagulation outweighs the bleeding risk has been shown to be 1-2% per year. The American Heart Association/American College of Cardiology/Heart Rhythm Society and the European Society of Cardiology (ESC) guidelines have adopted the CHA2DS2-VASc stroke risk score; their recommendations assume the scheme’s point scores correspond to fixed stroke rates. However, reported rates of stroke vary widely across cohorts, placing in question the generalizability of guideline recommendations. Objective: To contrast the reported rates of stroke in North American (NA) patients with AF who do not take OAC with the Danish AF cohort used to create the ESC guidelines. Methods: We conducted a systematic review to identify all cohort studies and randomized controlled trials including patients with non-valvular AF not treated with OAC. We excluded studies that enrolled only patients undergoing surgical procedures or cardioversion, or only patients with specific comorbidities such as prior stroke or kidney disease. Results: Of the 3,552 studies screened, we identified 13 eligible NA studies representing 137,652 patients. Larger and more contemporary cohorts generally had lower stroke rates (Table). When weighted by number of subjects, the NA cohorts’ ischemic stroke rate averaged 1.88% per year, whereas the Danish cohort had a rate of 4.66% per year. Conclusions: Large variation exists in stroke rates across putatively representative cohorts. This may reflect true differences in rates or methodologic differences among studies. These differences could change the point score threshold for recommending OAC in lower risk regions. Reexamining the net benefit of OAC in patients with a CHA2DS2-VASc score of 1 or 2 seems warranted, particularly for those with weak 1-point risk factors.
Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years
Authors: Sara C. Buttery, Divya Mohan, Marie Fisk, Nicholas S. Hopkinson, Ruth Tal-Singer, Ian B. Wilkinson, Michael I. Polkey
Journal: European Respiratory Journal (2017)

Skeletal muscle weakness is a distinct extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD), which is associated with a poor prognosis [1] and may represent a novel therapeutic target [2]. However, there are only sparse longitudinal data from prospective studies on skeletal muscle weakness and its relationship with disease progression in COPD. Previous studies have been cross-sectional in nature, and have failed to correlate data with baseline measures of exercise performance or systemic inflammation. The short physical performance battery may be a useful endpoint in assessing impact on skeletal muscle dysfunction <http://ow.ly/xf8z30dOFMz>
Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: final ENESTcmr randomized trial results
Authors: T P Hughes, B Leber, F Cervantes, N Spector, R Pasquini, N C D Clementino, A P Schwarer, P E Dorlhiac-Llacer, F-X Mahon, D Rea, A Guerci-Bresler, S Kamel-Reid, I Bendit, S Acharya, T Glynos, D Dalal, S Branford, J H Lipton
Journal: Leukemia (2017)

Sustained deep molecular responses in patients switched to nilotinib due to persistent  BCR-ABL1  on imatinib: final ENESTcmr randomized trial results
03.16 Regulatory t cells restrain autophagy in dendritic cells to ameliorate autoimmunity in a ctla4 dependent fashion
Authors: Themis Alissafi, Aggelos Banos, Louis Boon, Tim Sparwasser, Dimitrios Vassilopoulos, Dimitrios Boumpas, Triantafyllos Chavakis, Kenneth Cadwell, Panayotis Verginis
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Design of efficacious regulatory T cell (Tregs)-based therapies and establishment of clinical tolerance in autoimmune diseases has proven to be challenging. The clinical implementation of Treg immunotherapy has been hampered by various impediments concerning the stability and isolation procedures of Tregs but also the specific <i>in vivo</i> targets of Treg modalities. <h3>Materials and methods</h3> Peripheral blood samples were obtained from patients diagnosed with RA according to the ACR criteria. RA patients were treated with anti-TNFα treatment or CTLA4-Ig (Abatacept-Orencia, Bristol-Myers Squibb). Experimental Autoimmune Encephalomyelitis was induced in mice with administration of myelin peptide Mog<sub>35-55</sub> emulsified in CFA. <h3>Results</h3> Herein, we demonstrate that Foxp3<sup>+</sup> Tregs potently suppress autoimmune responses <i>in vivo</i> through inhibition of the autophagic machinery in DCs in a CTLA4-dependent manner. Autophagy deficient DCs exhibited reduced immunogenic potential and failed to prime autoantigen-specific CD4<sup>+</sup> T cells to mediate autoimmunity. Mechanistically, CTLA4 binding promoted the activation of PI3K/Akt/mTOR axis and FoxO1 nuclear exclusion in DCs leading to decreased transcription of the autophagy component <i>Lc3b</i>. Notably CTLA4-Ig (Abatacept)-treated human DCs demonstrated reduced levels of autophagosome formation, while DCs from Abatacept treated rheumatoid arthritis (RA) patients displayed diminished <i>Lc3b</i> transcripts. <h3>Conclusions</h3> Collectively, our data identify the canonical autophagy pathway in DCs as a novel molecular target of Foxp3<sup>+</sup> Treg-mediated suppression leading to amelioration of autoimmune responses. These findings may pave the way for the development of therapeutic protocols exploiting Tregs for the treatment of autoimmunity as well as diseases that disturbed tolerance is a common denominator.
Abstract 272: Sex Differences in β-Adrenergic Responsiveness of Excitation-Contraction Coupling in Isolated Rabbit Hearts
Authors: Gregory Hoeker, Ashleigh Hood, Rodolphe Katra, Steven Poelzing, Steven Pogwizd
Journal: Circulation Research (2014)

Introduction: Sex differences in β-adrenergic receptor (β-AR) responsiveness are associated with female cardioprotection. We hypothesize that female (F) rabbits have reduced responsiveness to β-AR stimulation vs males (M), and that the degree and type of sex differences vary with the β-AR subtypes that are activated. Methods: Ventricular action potentials (AP) and intracellular calcium transients (CaT) were optically mapped from the epicardial surface of rabbit hearts during 3 Hz pacing. Spontaneous calcium release (SCR) and ectopic activity were elicited at 1, 3, and 5.5 Hz. β-responsiveness was assessed with the nonselective β-agonist isoproterenol (Iso, 1-316 nM), or β2-AR selective agonist zinterol (Zin, 10 nM). Results: At baseline, the time constant of CaT decay (τ) was faster in F than M (54.0±1.7 vs 62.1±3.0 ms; n=14, 14; p &lt; 0.05), with no sex difference in CaT duration (CaD80). AP duration (APD90) was shorter in F than M (202.5±5.0 vs 218.2±5.7 ms; p &lt; 0.05). Iso decreased τ, CaD80, and APD90 in a dose-dependent manner in both sexes (n = 5, 5 for F, M). Iso decreased τ to a lesser extent in F than M for 1 and 32-316 nM Iso (F = 11-32 ms, M = 23-48 ms; p &lt; 0.05). The Iso-induced decrease in CaD80 was not significantly different in F than M at any dose. The Iso-induced decrease in APD90 was significantly less in F than M only at 316 nM Iso (75.5±8.7 ms vs 103.9±6.2 ms, p &lt; 0.05). In contrast, there were no sex differences in the response to Zin for τ, CaD80, or APD90 (n = 6, 6 for F, M). Zin decreased τ by 7.2±2.0 ms in F vs 12.7±3.7 ms in M; CaD80 by 18.0±5.3% in F vs 21.1±8.0 ms in M; and APD90 by 24.9±8.5 ms in F vs 21.9±8.9 ms in M. SCR was observed in 50% (6/12) of hearts treated with Zin, whereas Iso elicited SCR in all hearts (10/10) with a dose threshold of 32 nM. No ectopic beats were observed with Zin (0/36 trials in 12 hearts). With Iso, ectopic activity was less frequent in F hearts (16%, 12/75 trials in 5 hearts) than in M hearts (41%, 26/68 trials in 5 hearts, p &lt; 0.05). Conclusions: These results suggest that sex differences in AP and CaT depend on the dose of the agonist used and the β-AR subtypes that are activated. Elucidating nuances of sex differences in β-AR subtype physiology will provide a better understanding of the mechanisms of reduced β-responsiveness in F and its cardioprotective effects.
A SYSTEMATIC REVIEW OF THE ASSOCIATION BETWEEN ADIPOSITY AND SPORT INJURY RISK IN YOUTH
Authors: Clodagh Toomey, Declan Patton, Jackie Whittaker, Sarah Richmond, Carolyn Emery
Journal: British Journal of Sports Medicine (2017)

Background Obesity, defined as an accumulation of excessive fat mass that impairs health, is associated with lower levels of neuromuscular control including balance and coordination, which may place youth with higher adiposity at greater risk for injury during sport participation. On the opposite end of the spectrum, excessively low fat mass can also pose an injury risk. Objective To determine if adiposity is a risk factor for sport injury in children and adolescents. Design Systematic Review. Methods Ten electronic databases were systematically searched using key words and Medical Sub-Heading terms. Studies selected included: English language; original data; analytic design; adiposity measurement by age- and sex-adjusted body mass index (BMI) or body fat using imaging, impedance or predictive methods and; children, adolescents and young adults ≤20 years who sustained a musculoskeletal injury during sport or recreation participation that resulted in medical attention or time loss from sport or activities. PRISMA guidelines were followed and studies were assessed by two independent raters. Level of evidence was assessed using the Oxford Centre of Evidence-Based Medicine model. Results Of 8029 potentially relevant records, 44 were included in the final review. 75% of these studies were of prospective cohort design (level 2b evidence). Twenty-one studies concluded that a BMI rating of overweight/obese is a significant risk factor for injury; the majority (12/21) of these studies assessed lower extremity injury (e.g. ankle sprain and medial tibial stress syndrome). Nineteen studies showed no association between anthropometric measurement and injury; the majority (14/19) assessed all sport injury. Finally, a BMI rating of underweight (4 studies) was more commonly associated with risk of stress fracture. Conclusions There is consistent level 2b evidence that a rating of overweight/obesity is associated with lower extremity injury. Anthropometric risk of injury appears to be dependent on type and site of injury in youth sport.
りょう藍(Polygonum tinctorium Lour.)に含まれる悪性腫よう細胞傷害物質について
Authors: 木本哲夫, 山本祐規子, 日野恵子, 古谷聡美, 阿賀創, 橋本貴治, 花谷利春, 新井成之, 栗本雅司
Journal: Nature Medicine (1999)