tbuckley/cabot-search huggingface dataset:
Hepatic Falciform Artery Demonstrating MAA Uptake in the Anterior Abdomen Prior to Embolization
Authors: Dhruv Patel, Ken Le, Joga Chaganti, Robert Mansberg
Journal: Clinical Nuclear Medicine (2017)

A 58-year-old man was referred for selective internal radiation therapy for locally advanced unresectable hepatocellular carcinoma. Intra-arterial particle perfusion scintigraphy was performed with SPECT/CT following intra-arterial injection of Tc macroaggregated albumin. Angiography demonstrated a hepatic falciform artery, a feeding artery of the ligamentum teres, whereas scintigraphy demonstrated tracer uptake in the mid-anterior abdominal wall. The hepatic falciform artery was subsequently embolized and the repeat angiogram confirmed successful occlusion. Subsequent post-selective internal radiation therapy PET/CT images did not reveal any tracer uptake in the mid-anterior abdominal wall.
Safety of alectinib in non-small cell lung cancer patients with RET fusion gene (ALL-RET): Results from the dose-finding portion of a phase 1/2 study
Authors: K. Nosaki, S. Takeuchi, S. Takahara, T. Kawakami, K. Yoh, Y. Kono, A. Horiike, T. Seto, K. Goto, K. Yoshimura, Y. Imai, T. Murayama, S. Yano
Journal: Annals of Oncology (2017)
Fear of recurrence among cancer survivors.
Authors: Rachel B Jimenez, Giselle Katiria Perez, Julia Rabin, Daniel Hall, Katharine Quain, Elyse Park, Jeffrey M. Peppercorn
Journal: Journal of Clinical Oncology (2017)

10053 Background: Fear of cancer recurrence (FoCR) following definitive cancer therapy is often reported by patients, but little is known about who is most likely to be impacted, how FoCR influences emotional distress, and what interventions may mitigate patients’ FoCR. We sought to determine the prevalence of FoCR among cancer survivors and to evaluate potential predictors of FoCR in this population. Methods: As part of a comprehensive supportive care needs assessment, we evaluated the prevalence of FoCR among patients receiving follow-up cancer care at our institution as well as factors associated with FoCR. Elevated FoCR was measured with a single item: “I worry about my cancer coming back” rated on a 4-point Likert scale (1 = “not at all” to 4 = ”very much”); responses of 3 or 4 were considered positive for FoCR. Descriptive statistics were used to characterize patterns of FoCR. Chi-square and Fisher’s exact tests compared differences in emotional, clinical, and demographic characteristics between participants with and without FoCR, as well as interest in and knowledge of survivorship services. Results: Of 636 patients who completed the survey, 318/636 (50.0%) patients had curable cancer and had either completed cancer therapy or were completing maintenance treatment. On inquiry, 167/318 (53%) reported FoCR. Those with FoCR were more likely to be female (p &lt; 0.002) and under the age of 70 (p &lt; 0.003). They were also more likely to be sad (25% vs. 14%, p &lt; 0.015), anxious (40% vs. 21% p &lt; 0.0005), feel uncertain about the future (30% vs. 14%, p &lt; 0.0005), have problems managing stress (26% vs. 13%, p &lt; 0.003), and were more likely to worry about dying (55% vs. 8%, p &lt; 0.0001) and to fear another cancer (74% vs. 8% p &lt; 0.0001). Education level, cancer type, knowledge of and interest in support services, and survivorship care plan receipt were not associated with FoCR. Conclusions: Patient FoCR is prevalent among more than half of survivors of cancer and is associated with emotional distress that is insufficiently addressed by survivor care planning and supportive services. Clinicians can and should screen for and address this issue. Future research is needed to develop and test interventions, beyond care plans, to address FoCR in both low risk and high risk patient populations.
A campanha de vacinação contra a doença meningocócica numa área rural da Holanda – Janeiro de 1998
Authors: J. E. van Steenbergen, A. G. Kraayeveld, L Spanjaard
Journal: Eurosurveillance (1999)

A Neisseria meningitidis do grupo C causa, regularmente, epidemias em escolas, universidades e unidades militares e, na ultima decada, foram relatados surtos na comunidade (1). Desde que existe uma vacina polissacarida segura, tem sido, repetidamente, levantada a questao se se deve disponibiliza-la e quando. A delimitacao dos grupos alvo para a vacina e sempre dificil e e um processo arbitrario definido por varias consideracoes.
Echocardiographic changes with non-invasive ventilation and CPAP in obesity hypoventilation syndrome
Authors: Jaime Corral, Maria Victoria Mogollon, M-Ángeles Sánchez-Quiroga, Javier Gómez de Terreros, Auxiliadora Romero, Candela Caballero, Joaquin Teran-Santos, María L Alonso-Álvarez, Teresa Gómez-García, Mónica González, Soledad López-Martínez, Pilar de Lucas, José M Marin, Odile Romero, Trinidad Díaz-Cambriles, Eusebi Chiner, Carlos Egea, Roberto M Lang, Babak Mokhlesi, Juan F Masa
Journal: Thorax (2017)

Rationale Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on cardiac structure and function assessed by echocardiography. Objectives We performed a secondary analysis of the data from the largest multicentre randomised controlled trial of OHS (Pickwick project, n=221) to determine the comparative efficacy of 2 months of NIV (n=71), CPAP (n=80) and lifestyle modification (control group, n=70) on structural and functional echocardiographic changes. Methods Conventional transthoracic two-dimensional and Doppler echocardiograms were obtained at baseline and after 2 months. Echocardiographers at each site were blinded to the treatment arms. Statistical analysis was performed using intention-to-treat analysis. Results At baseline, 55% of patients had pulmonary hypertension and 51% had evidence of left ventricular hypertrophy. Treatment with NIV, but not CPAP, lowered systolic pulmonary artery pressure (−3.4 mm Hg, 95% CI −5.3 to –1.5; adjusted P=0.025 vs control and P=0.033 vs CPAP). The degree of improvement in systolic pulmonary artery pressure was greater in patients treated with NIV who had pulmonary hypertension at baseline (−6.4 mm Hg, 95% CI −9 to –3.8). Only NIV therapy decreased left ventricular hypertrophy with a significant reduction in left ventricular mass index (−5.7 g/m 2 ; 95% CI −11.0 to –4.4). After adjusted analysis, NIV was superior to control group in improving left ventricular mass index (P=0.015). Only treatment with NIV led to a significant improvement in 6 min walk distance (32 m; 95% CI 19 to 46). Conclusion In patients with OHS, medium-term treatment with NIV is more effective than CPAP and lifestyle modification in improving pulmonary hypertension, left ventricular hypertrophy and functional outcomes. Long-term studies are needed to confirm these results. Trial registration number Pre-results, NCT01405976 ( https://clinicaltrials.gov/ ).
Comparing physician and nurse ECOG performance status ratings as predictors of clinical outcomes in cancer patients.
Authors: Elad Neeman, Gillian Gresham, Andrew Eugene Hendifar, Richard Tuli, Robert A. Figlin, Arvind Manohar Shinde
Journal: Journal of Clinical Oncology (2017)

248 Background: The Eastern Cooperative Oncology Group Performance Status (ECOG) scale is commonly used in the clinical and research setting, and has been shown to correlate with cancer morbidity, mortality, and tolerance to chemotherapy. ECOG is frequently rated by physicians (MDs) and nurses (RNs), and MD-RN ECOG score agreement varies widely in the literature. It remains unclear whether MD and RN ECOG scores differ in their ability to predict clinical outcomes. Methods: As part of a quality initiative at Cedars-Sinai Cancer Center, oncologists and chemotherapy RNs independently scored ECOGs for a random sample of 309 patients with various solid malignancies, on one or more visits, for a total of 506 pairs of ECOG scores. MD/RN interrater agreement was evaluated using the Cohen's kappa coefficient. Logistic regression models were fit to evaluate the ability of RN and MD ECOG scores, as well as the RN-MD score difference, to predict the occurrence of chemotoxicity (CTCAE v4, grade≳3) and hospitalizations within 1 month from ECOG ratings as well as 6-month mortality/hospice referrals. Results: The agreement among 506 ECOG MD/RN pairs was 71% (Kappa = 0.485, p &lt; 0.0001). RN ECOGs had a stronger odds ratio (OR) for 6-month mortality/hospice (OR = 3.55, CI 2.2-5.7) compared to MD ECOGs (OR = 2.99, CI 1.67-5.3). RN ECOG scores also significantly correlated with one-month chemotoxicity (OR = 1.39, CI 1.02-1.90), but MD ECOGs did not. Both MD and RN ECOG scores did not significantly correlate with 1-month hospitalizations. The magnitude of RN to MD ECOG score difference was also positively associated with 6-month mortality/hospice (OR = 3.42, CI 1.87-6.3), but not with 1-month hospitalization or chemotoxicity. Conclusions: Our findings suggest that RN-rated ECOGs may be stronger predictors of chemotoxicity and 6-month mortality/hospice compared to MD ECOGs. Furthermore, the magnitude of difference between ECOG MD and RN ratings was associated with increased mortality/hospice rates, specifically when the MD rating was “healthier” than that of the RN. As ECOG scores are frequently used for prognostication and to inform treatment decisions, ECOG scoring by RNs may result in additional clinical benefit.
Live theatre as exception and test case for experiencing negative emotions in art
Authors: Thalia R. Goldstein
Journal: Behavioral and Brain Sciences (2017)

Abstract Distancing and then embracing constitutes a useful way of thinking about the paradox of aesthetic pleasure. However, the model does not account for live theatre. When live actors perform behaviors perceptually close to real life and possibly really experienced by the actors, audiences may experience autonomic reactions, with less distance, or may have to distance post-experiencing/embracing their emotions.
Association of 25(OH)D3 with outcomes in renal cell carcinoma
Authors: A. Mustafa, A. Bulbul, T. Braik, E.A. Mino, S. Chouial, H. Aboud, S. Rashad, A. Bautista, M. Khorsand, T. Dorff
Journal: Annals of Oncology (2017)
Abstract 20622: Combined Treatment of Microgroove- Induced Alignment, Triiodothyronine and Electrical Conditioning Promotes Functional Maturation of Human Pluripotent Stem Cell- Derived Cardiomyocytes in Engineered Cardiac Monolayers
Authors: Andy O Wong, Lin Geng, Maggie Z Chow, Angie Shum, Eugene K Lee, Roger Tu, Bo Shen, Hongkai Wu, Marco Kong, Wendy Keung, Michelle Khine, Yiu-Fai Cheung, Ronald A Li
Journal: Circulation (2016)

Human pluripotent stem cell (hPSC) derived cardiomyocytes (CMs) and their engineered tissues display low anisotropic ratio (AR) and conduction velocity (CV), high spontaneity and poor calcium handl...
Improving advanced care planning in patients with metastatic cancer.
Authors: Tallat Mahmood
Journal: Journal of Clinical Oncology (2017)

6 Background: Our group as a member of the Michigan Oncology quality Consortium (MOQC) participates in ongoing quality metric evaluations every spring and fall. Through this exercise we found we were performing low on the advance care planning (ACP) metrics. To address this we first realized we did not had a consistent place in the HER to document this. We created an ACP note and then worked on identifying a patient advocate and starting the ACP process. Methods: We first assessed our standard practice prior to joining MOQC and found we were entirely dependent upon the physician to initiate the discussion and often this was being done by the physician only at the time of disease progression. We then garnered the healthcare team to help with the process. The medical assistants (MA) would give the patient the DPOA/ACP forms with a brief explanation of the forms. This would be reiterated by the provider. On subsequent visits, the MA would ask the patient about the status of the form and if it had been filled out, and if not the nurse was flagged to call the patients . The physician assistant starting discussing the DPOA/ACP form in the chemo teach sessions. We then audited the charts of 100 patients’ after implementing the changes and compared them to our historic data from MOQC. Results: By implementing these changes we were able to increase our hospice enrollment from 47% to 66%; and our documented discussion of ACP went from 27% to 83%. However 25% of our patients still died in the hospital and we were consulted on only 50% of the hospitalized patients. Conclusions: Although we were able to improve referrals to hospice and increase discussion of ACP, there is still much work to be done. Despite the improvements we saw in the documentation of end of life discussions there was still a significant number of patietns who were admitted to the hospital at the end of life and who died in the hospital. One of the reasons could be the lack of communication with admitting providers as we were consulted in only 50% of those patients.
Circulating tumor DNA detection in primary breast cancer patients by targeted sequencing: Consistency with tumor DNA and factors influencing detection
Authors: Z. Yidong, W. Changjun, Z. Yanyan, G. Yuhua, G. Yanfang, P. Li, Y. Ling, Y. Xin, X. Xuefeng, S. Qiang
Journal: Annals of Oncology (2017)
Abstract 21177: Seamless Gene Correction of <i>LDLR</i> in Familial Hypercholesterolemia Induced Pluripotent Stem Cells Mediated by CRISPR/Cas9 and <i>PiggyBac</i>
Authors: Rui Wei, Jiayin Yang, Hung-Fat Tse
Journal: Circulation (2017)

Introduction: Familial hypercholesterolemia (FH) is an autosomal disorder, characterized by elevated circulating lipoproteins and high risk of premature coronary heart disease. Mutations in low-density lipoprotein receptor gene (LDLR) is one of the major causes. Induced pluripotent stem cell (iPSC) technology helps us generate cell model with patient-specific genetic background. In this study, we aimed to correct LDLR mutation in iPSCs reprogrammed from an FH patient, using CRISPR/Cas9 and piggyBac . Methods: Patient-specific iPSCs were generated from an FH patient with heterozygous duplication of “TGCTGGC” (c.2108_2114dup, p.Ala705fsX14) in exon 14 of LDLR. CRISPR/Cas9 targeting the mutation site and piggyBac were employed to correct the mutation via homologous recombination. Corrected iPSCs were subjected to karyotype analysis, and a series of tests of pluripotency, then differentiated into hepatocyte-like cells (iHeps) to assess the LDLR function in vitro and in vivo . Results and conclusions: We designed two sgRNAs which showed high cutting efficiency in the target site. Co-delivery of CRISPR/Cas9 and piggyBac in FH iPSCs facilitates the integration of donor constructs in the target site with high efficiency. Then, the drug selection cassette was removed by hyPBase expression vectors. After two rounds of genetic manipulation, we achieved a seamless genetic correction in iPSCs, which showed retain full pluripotency and normal karyotypes. In addition, the corrected iPSCs can be differentiated into functional iHeps efficiently, and these iHeps showed restored function of LDLR, characterized by recovery of LDL receptor expression levels and the capacity of LDL uptake. Our study highlights the feasibility of using CRISRP/Cas9 and piggyBac to generate seamless, genetically corrected patient-specific iPSCs, and functional iHeps. These genetically corrected cells are not only ideal models for disease modeling, but also the potential source for autologous cell replacement therapies. Acknowledgment: This work was supported by the Shenzhen Science and Technology Council Basic Research program (JCYJ20150331142757383), the Hong Kong Research Grant Council Theme Based Research Scheme (T12-705/11).
Building Capacity for Evidence-Based Public Health: Reconciling the Pulls of Practice and the Push of Research
Authors: Ross C. Brownson, Jonathan E. Fielding, Lawrence W. Green
Journal: Annual Review of Public Health (2017)

Timely implementation of principles of evidence-based public health (EBPH) is critical for bridging the gap between discovery of new knowledge and its application. Public health organizations need sufficient capacity (the availability of resources, structures, and workforce to plan, deliver, and evaluate the preventive dose of an evidence-based intervention) to move science to practice. We review principles of EBPH, the importance of capacity building to advance evidence-based approaches, promising approaches for capacity building, and future areas for research and practice. Although there is general agreement among practitioners and scientists on the importance of EBPH, there is less clarity on the definition of evidence, how to find it, and how, when, and where to use it. Capacity for EBPH is needed among both individuals and organizations. Capacity can be strengthened via training, use of tools, technical assistance, assessment and feedback, peer networking, and incentives. Modest investments in EBPH capacity building will foster more effective public health practice.
Assessment of Symptom Network Density as a Prognostic Marker of Treatment Response in Adolescent Depression
Authors: Lizanne Schweren, Claudia D. van Borkulo, Eiko Fried, Ian M. Goodyer
Journal: JAMA Psychiatry (2017)

reported by Jansen et al 4 in 3-year-old children.Research suggests that impaired neuromotor development precedes schizophrenia onset, although most children with impaired neuromotor functioning do not develop schizophrenia. 2 In contrast, children who later met criteria for BD exhibited a higher level of motor performance during childhood than controls. 1 Our results highlight that the genetic predisposition for schizophrenia covaries with motor deficits observable during infancy in a community-based sample.Given that the prevalence of schizophrenia is low, these early features represent indices of liability rather than precursors of the disorder.This study has certain limitations.Genetic pleiotropy or early environmental factors could also explain the association. 1 Selective nonresponse to neuromotor assessment could bias the analysis.The power of the BD GWAS might have been insufficient to detect associations between BD PRS and neuromotor development.Despite limitations, this study has several strengths, including an objective and prospectively assessed measure of neuromotor development in a large homogenous sample of infants.To our knowledge, this is the first evidence that genetic liability for schizophrenia may covary with altered neuromotor development in infancy.
Retrospective study of atypical femoral fracture in patients with malignant bone metastasis receiving denosumab therapy: Case series
Authors: Y. Ozaki, M. Takahashi, H. Nakajima, R. Ohki, J. Masuda, C. Kondoh, Y. Miura, Y. Tanabe, T. Takano
Journal: Annals of Oncology (2017)
Is there a link between BRCA1 and BRCA2 mutations and obesity, high blood pressure and diabetes mellitus in Romanian high-risk breast cancer cases?
Authors: N. Antone, L. Pop, E. Dronca, A. Stoian, R. Matei, M. Ligtenberg, H. Ouchene, A. Onisim, O. Rotaru, R. Eniu, A. Eniu
Journal: Annals of Oncology (2017)
A method of high-throughput functional evaluation of <i>EGFR</i> gene variants of unknown significance in cancer
Authors: Shinji Kohsaka, Masaaki Nagano, Toshihide Ueno, Yoshiyuki Suehara, Takuo Hayashi, Naoko Shimada, Kazuhisa Takahashi, Kenji Suzuki, Kazuya Takamochi, Fumiyuki Takahashi, Hiroyuki Mano
Journal: Science Translational Medicine (2017)

A method for high-throughput functional analysis identifies drug-insensitive EGFR mutations in tumors.
Phase II trial of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for previously untreated advanced non-squamous non-small cell lung cancer
Authors: T. Uenami, T. Koba, S. Minami, Y. Futami, K. Masuhiro, H. Kimura, S. Futami, M. Yaga, M. Mori, H. Kagawa, S. Komo, T. Otsuka, S. Yamamoto, K. Komuta, T. Kijima
Journal: Annals of Oncology (2017)
FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction
Authors: Shi-Yi Zhou, Merritt Gillilland, Xiaoyin Wu, Pornchai Leelasinjaroen, Guanpo Zhang, Hui Zhou, Bo Ye, Yuanxu Lu, Chung Owyang
Journal: Journal of Clinical Investigation (2017)

Foods high in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) exacerbate symptoms of irritable bowel syndrome (IBS); however, their mechanism of action is unknown. We hypothesized that a high-FODMAP (HFM) diet increases visceral nociception by inducing dysbiosis and that the FODMAP-altered gut microbial community leads to intestinal pathology. We fed rats an HFM and showed that HFM increases rat fecal Gram-negative bacteria, elevates lipopolysaccharides (LPS), and induces intestinal pathology, as indicated by inflammation, barrier dysfunction, and visceral hypersensitivity (VH). These manifestations were prevented by antibiotics and reversed by low-FODMAP (LFM) diet. Additionally, intracolonic administration of LPS or fecal supernatant (FS) from HFM-fed rats caused intestinal barrier dysfunction and VH, which were blocked by the LPS antagonist LPS-RS or by TLR4 knockdown. Fecal LPS was higher in IBS patients than in healthy subjects (HS), and IBS patients on a 4-week LFM diet had improved IBS symptoms and reduced fecal LPS levels. Intracolonic administration of FS from IBS patients, but not FS from HS or LFM-treated IBS patients, induced VH in rats, which was ameliorated by LPS-RS. Our findings indicate that HFM-associated gut dysbiosis and elevated fecal LPS levels induce intestinal pathology, thereby modulating visceral nociception and IBS symptomatology, and might provide an explanation for the success of LFM diet in IBS patients.
La tuberculose pulmonaire dans deux centres de détention préventive à St-Pétersbourg, Russie
Authors: T Lobacheva, V Sazhin, E Vdovichenko, J Giesecke
Journal: Eurosurveillance (2005)

La situation de la tuberculose (TB) dans le systeme penitentiaire russe a ete souvent decrite. Nous avons realise une etude epidemiologique descriptive de la TB dans deux centres de detention preventive (SIZO) de St-Petersbourg. Les cas de TB diagnostiques entre le 1er janvier 2000 et le 31 decembre 2002 ont ete recherches dans les bases de donnees medicales de ces centres de detentions. La methode de diagnostic la plus frequente etait la radiologie pulmonaire. 
Au total, 876 cas de TB ont ete rapportes dans ces deux centres au cours de cette periode de trois ans. Dans 432 cas, le diagnostic a ete porte a l’entree en prison, et dans 444 cas la maladie s’est declaree au cours de l’incarceration, la proportion de cas diagnostiques pendant l’incarceration augmentant au cours du temps. La majorite des cas etaient âges de moins de 30 ans. 
L’incidence de la TB dans les centres de detention preventive en Russie reste tres elevee et necessite une surveillance rigoureuse.