tbuckley/cabot-search huggingface dataset:
Annals Consult Guys – PE in Pregnancy: What Imaging? What Drugs?
Authors: Geno J. Merli, Howard H. Weitz
Journal: Annals of Internal Medicine (2018)

Web Exclusives21 August 2018Annals Consult Guys – PE in Pregnancy: What Imaging? What Drugs?FREEGeno J. Merli, MD and Howard H. Weitz, MDGeno J. Merli, MDThomas Jefferson University, Philadelphia, Pennsylvania (G.J.M., H.H.W.)Search for more papers by this author and Howard H. Weitz, MDThomas Jefferson University, Philadelphia, Pennsylvania (G.J.M., H.H.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W18-0013 SectionsSupplemental MaterialAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this episode of the consultative medicine talk show, Geno and Howard address the tricky topic of venous thromboembolism during pregnancy.For more videos from and information on Annals Consult Guys, visit go.annals.org/ConsultGuys.. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Thomas Jefferson University, Philadelphia, Pennsylvania (G.J.M., H.H.W.)Disclosures: Geno J. Merli, MD, reports the following: Research grants/contracts: Bristol-Myers Squibb, Bayer. Howard H. Weitz, MD, reports that he has no financial relationships or interests to disclose.Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that her spouse has stock options/holdings with Targeted Diagnostics and Therapeutics. Darren B. Taichman, MD, PhD, Executive Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Deborah Cotton, MD, MPH, Deputy Editor, reports that she has no financial relationships or interest to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Catharine B. Stack, PhD, MS, Deputy Editor for Statistics, reports that she has stock holdings in Proctor & Gamble, Pfizer, and Johnson & Johnson. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 August 2018Volume 169, Issue 4Page: CG1KeywordsDiagnostic techniquesDisclosureDrugsPregnancyResearch grantsResearch reporting guidelinesVenous thromboembolism ePublished: 21 August 2018 Issue Published: 21 August 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.Loading ...
Abstract 15538: Referral to Coronary Angiography Subsequent to an Abnormal Stress-Only SPECT Study: Expanding the Concept Beyond the Normal Scan
Authors: Harshal R Patil, Nirav T Patil, Randall C Thompson, Kevin A Bybee, James H O’Keefe, Iain A McGhie, Timothy M Bateman
Journal: Circulation (2013)

BACKGROUND: Current standards are to perform rest imaging when the stress scan is abnormal, as no data exists as to diagnostic accuracy of stress only (SO) SPECT image. We therefore studied 145 consecutive patients who underwent stress only (SO) SPECT and were referred to coronary angiography (CA) within 30 days and no change in symptoms. METHODS: From 1/2005 to 4/2013, 145 pts who had a SO SPECT and underwent CA were included. A summed stress score (SSS) of ≥3 for non-attenuation corrected (AC) and ≥ 2 for AC SPECT was defined as abnormal. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for significant CAD (≥70%) as well as in relation to single and multivessel CAD, gender, BMI, and stress modality was determined. Statistical significance was calculated using Chi Square and unpaired t test. RESULTS: Average age and BMI was 59.7 ± 10.6 yrs and 30.2 ± 6.2 kg/m2 respectively. 70% were male, 29% had known CAD, 23% were diabetic, 70% had hypertension, 26% were smo...
Abstract 11774: Beyond Restenosis - Patients’ Preferences for Drug Eluting versus Bare Metal Stents
Authors: Mohammed Qintar, Adnan K Chhatriwalla, Javed M Ashraf, Donna M Buchanan, Fengming Tang, Philip Jones, John A Spertus
Journal: Circulation (2015)

Introduction: Drug eluting stents (DES) reduce the need for target vessel revascularization, and are used in ~80% of percutaneous coronary interventions (PCI) in the US. However, DES also necessitate the use of prolonged dual anti-platelet therapy (DAPT), which is associated with increased bleeding/bruises, can complicate future surgeries and can increase patients’ medication costs (DAPT drawbacks). Patients’ preferences regarding the benefits of DES and DAPT drawbacks have not previously been studied or reported. Methods: In a prospective, observational cohort study, consecutive patients undergoing PCI at 2 Kansas City hospitals completed a survey assessing the importance of the following factors related to the decision to receive DES: need for repeat PCI and DAPT drawbacks. Each factor was rated from 1 (not important) to 10 (extremely important). The most important factor, or group of factors, to each patient was then identified. Results: Among 317 PCI patients (66% male, 71% white, 45% DM, 80% HTN, 43% with prior PCI), 21% did not consider the need for repeat PCI as the most important factor (Figure). Only 14% considered the need for repeat PCI the single most important factor and 65% considered at least one DAPT drawback as important as repeat PCI. A third (32.8%) ranked minor bleeding/bruising as the most important factor (alone (5.5%) or with other domains (27.3%)). Conclusions: While the need for repeat PCI is an important factor to patients considering stent options, 85% of PCI patients regard other factors to be at least as important. Eliciting patients’ preferences is important to better tailor stent choices to the goals and values of individual patients undergoing PCI.
Changes in Buprenorphine-Naloxone and Opioid Pain Reliever Prescriptions After the Affordable Care Act Medicaid Expansion
Authors: Brendan Saloner, Jonathan Levin, Hsien-Yen Chang, Christopher Jones, G. Caleb Alexander
Journal: JAMA Network Open (2018)

Expanding Medicaid eligibility could affect prescriptions of buprenorphine with naloxone, an established treatment for opioid use disorder, and opioid pain relievers (OPRs).To examine changes in prescriptions of buprenorphine with naloxone and OPRs after the US Affordable Care Act Medicaid expansion.In this cohort study, longitudinal, patient-level, retail pharmacy claims were extracted from IQVIA real-world data from an anonymized, longitudinal, prescription database. The sample included 11.9 million individuals who filled 2 or more prescriptions for a prescription opioid during at least 1 year between January 1, 2010, and December 31, 2015, from California, Maryland, and Washington (expansion states) and Florida and Georgia (nonexpansion states). Data analysis was conducted from August 1, 2017, to May 31, 2018. Data were aggregated to county-year observations (N = 2082) and linked to county-level covariates. For each outcome, a difference-in-differences regression model was estimated comparing changes before and after expansion in expansion vs nonexpansion counties. Models were adjusted for county demographics, uninsured rate, and overdose mortality in the baseline year (2010).Presence of Medicaid expansion in the year.For buprenorphine with naloxone and OPRs, rates per 100 000 county residents were calculated separately for any prescriptions overall and by different payment sources. Mean days of medication per county among people filling prescriptions for these agents were also determined.The study sample included 11.9 million individuals (expansion states: 40.9% men; mean [SD] age, 44.1 [13.8] years; nonexpansion states: 41.0% men; mean [SD] age, 43.7 [13.7] years). In expansion counties, 68.8 individuals per 100 000 county residents filled buprenorphine with naloxone and 5298.3 filled OPR prescriptions in 2010. After expansion, buprenorphine with naloxone fills per 100 000 county residents increased significantly in expansion relative to nonexpansion counties (8.7; 95% CI, 1.7 to 15.7). Opioid pain reliever fills per 100 000 county residents did not significantly change in expansion counties relative to nonexpansion counties (327.4; 95% CI -202.5 to 857.4). The rate of OPRs per 100 000 county residents paid for by Medicaid significantly increased (374.0; 95% CI, 258.3 to 489.7). There were no significant changes in days per 100 000 county residents of either medication after expansion.Medicaid expansion significantly increased buprenorphine with naloxone prescriptions per 100 000 county residents in expansion counties, suggesting that expansion improved access to opioid use disorder treatment. Expansion did not significantly increase the overall rate per 100 000 county residents of OPR prescriptions, but increased the population with OPRs paid for by Medicaid. This finding therefore suggests the growing importance of Medicaid in pain management and addiction prevention.
Orphan Cancer Drugs in the Era of Precision Medicine
Authors: Chadi Nabhan, Eli G. Phillips, Bruce A. Feinberg
Journal: JAMA Oncology (2018)

This Viewpoint discusses whether the changes in the health care marketplace, the evolution of precision medicine, and the uniqueness of drug development and labeling for cancer diagnoses make the Orphan Drug Act less necessary and less relevant today than at its inception.
Abstract 17911: Genetic Overexpression of the Hydrogen Sulfide Producing Enzyme Cystathionine gama-Lyase in Endothelial Cells Enhances Hydrogen Sulfide and Nitric Oxide Signaling
Authors: Zhen Li, David J Polhemus, Chelsea L Organ, John W Elrod, David J Lefer
Journal: Circulation (2016)

Background: Endogenous generation of H2S is critical for cardiovascular homeostasis. H2S deficiency associated with cardiovascular disease disrupts NO signaling via dysregulation of endothelial nit...
Abstract 13819: Delayed Enhancement Cardiac Magnetic Resonance Imaging Predicts Response to Cardiac Resynchronization Therapy
Authors: Akbar H Khan, Ryan M Gage, Ambareesh Bajpai, Imran S Syed, Kevin V Burns, Alan J Bank
Journal: Circulation (2016)

Introduction: Primary predictors of cardiac resynchronization therapy (CRT) are based on conduction system characteristics, such as QRS duration and morphology. The ability of MRI to predict CRT response is less understood. Methods: We studied 83 patients who received cardiac MRI with gadolinium delayed enhancement (DE) prior to CRT. Patients had preCRT EF ≤ 40%, preCRT QRS ≥ 120ms, and paired ~1 year postCRT echocardiograms. MRIs were read without knowledge of patient characteristics or CRT outcomes and echocardiograms were read in a core-lab blinded to MRI results. Results: Patients were classified as having no DE (n=27), only septal midwall DE (n=20), or scar / DE (transmural, subendocardial, or subepicardial) (n=36). Prior to CRT, those with septal midwall DE (25 ± 7) had lower EFs than those with scar / DE (31 ± 6, p=0&lt;0.01), but not statistically different from those without DE (29 ± 6). Those without DE had better (p&lt;0.001) EF (14.2 ± 10 units) and LVESV improvements (-42 ± 21%) following CRT than those with midwall DE (EF: 2.1 ± 9 units; LVESV: -3 ± 35%) or those with scar / DE (EF: 1.4 ± 8 units; LVESV: -5 ± 25%). There was no difference in CRT response between non-ischemics with septal midwall DE and patients with scar / DE. In univariate regression models LBBB tended (p=0.12) to predict a beneficial EF response to CRT while presence of midwall DE was highly significant (p&lt;0.001) for predicting a lack of response in the 47 patients without scar. In a multivariate model including many baseline characteristics, septal midwall DE provided predictive value (p&lt;0.001) for EF response whereas the common predictors of gender (p=0.693) and LBBB (p=0.913) did not. Conclusions: DE cardiac MRI is a good predictor of response to CRT. The absence of any DE predicts a significant improvement in EF and LV volumes. In the idiopathic non-ischemic population the presence of septal midwall DE was a better negative predictor of response than more traditional characteristics of LBBB and gender. In addition, the presence of transmural, subendocardial, or subepicardial scar also predicted lack of improvement in LV function and volumes with CRT. The information obtained from DE MRI could help determine which patients would be best helped by CRT.
The role of PET-CT in treatment decision making for women with locally advanced cervical cancer.
Authors: Lorraine Margaret Elit, Anthony W. Fyles, Chu-Shu Gu, Gregory Russell Pond, David D'Souza, Rajiv Samant, Margaret Anthes, Gillian Thomas, Marc Fillion, Julie Arsenault, Ian Dayes, Timothy Joseph Whelan, Karen Y. Gulenchyn, Mark Norman Levine
Journal: Journal of Clinical Oncology (2015)

5523 Background: Women with locally advanced cervical cancer (LACC) are treated with concurrent chemotherapy and radiation therapy (CRT) with curative intent. Pre-treatment staging is important to ...
Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration
Authors: Fanny Herisson, Vanessa Frodermann, Gabriel Courties, David Rohde, Yuan Sun, Katrien Vandoorne, Gregory R. Wojtkiewicz, Gustavo Santos Masson, Claudio Vinegoni, Jiwon Kim, Dong-Eog Kim, Ralph Weissleder, Filip K. Swirski, Michael A. Moskowitz, Matthias Nahrendorf
Journal: Nature Neuroscience (2018)
Oral Rehydration Therapy for Diarrheal Diseases
Authors: Roger I. Glass, Barbara J. Stoll
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19260: Predictive Value of Circulating Biomarkers of Collagen Metabolism Following Catheter Ablation of Atrial Fibrillation
Authors: Alberto Pérez-Castellanos, Felipe Atienza, Begoña López, José Miguel Ormaetxe, Jesús Daniel Martínez-Alday, Miguel Ángel Arias, Marta Pachón, María Fe Arcocha, Ángel Arenal, Javier Díez, Francisco Fernández-Avilés
Journal: Circulation (2015)

Introduction: Myocardial fibrosis plays an important role in the pathogenesis of atrial fibrillation (AF). However, catheter ablation may eliminate AF sources but also increases fibrosis. We aimed to assess the predictive value of circulating biomarkers of collagen metabolism following AF catheter ablation. Methods: Serum levels (ELISA) of biomarkers of collagen metabolism were analyzed in patients undergoing AF ablation (62 paroxysmal, 67 persistent) at baseline and 12 months after ablation. Biomarkers levels in 20 patients in sinus rhythm were also evaluated to establish the normal values. Results: Before ablation, there was a direct linear correlation between PICP (carboxy-terminal propeptide of procollagen type I) levels and left atrial diameter for the overall sample (p=0.006). PICP levels at baseline were lower in paroxysmal AF patients with vs. without AF recurrences following ablation (68.30 ± 9.66μg/l vs 90.72 ± 3.78μg/l; p=0.017). At 12 months following ablation of paroxysmal patients, PICP levels significantly increased only in patients with AF recurrences (21.74μg/l vs -0.12 μg/l, Figure). There were no significant changes in biomarkers levels in persistent AF patients at baseline or during follow-up. Conclusions: Progressive increase of PICP levels following catheter ablation of AF is related with arrhythmia recurrence in paroxysmal AF patients. This result suggests that ablation may increase collagen turnover in non-responders paroxysmal AF patients.
Abstract 12571: Social Network Analysis Demonstrating Impact of Resuscitation Outcome Consortium (ROC) on Collaboration
Authors: Denisse Sequeira, Daniel Patterson, Francis X Guyette
Journal: Circulation (2016)

Introduction: National Institute of Health (NIH) funded ROC to create an infrastructure that would support clinical resuscitation research and facilitate collaboration among investigators from numerous institutions. While collaborations are key elements of scientific productivity, few have formally quantified collaboration over time. Social Network Analysis (SNA ) is widely used in social and clinical science to quantify and illustrate network relationships.We sought to characterize collaboration and cohesion amongst ROC investigators using (SNA) techniques. Hypothesis: The number of collaborations between participating sites increased after the introduction of a clinical research consortium. Methods: Lists of publications were abstracted from PubMed for investigators listed as contributing authors on at least one ROC publication. Publications were abstracted from two different time periods: 2003-2005 and 2013-2015 the time periods before the creation of ROC and after. The number of co-authorships was used to construct a matrix analyzed using UCINET Version 6.205 to calculate density as well as a network sociogram illustrating the collaborations. Density refers to the overall measure of interaction. Values range from 0-100, higher values indicate greater cohesion and collaboration between nodes (members) in a defined network. Results: The network density was 1.4% in the time period before ROC and increased to 29.7%. In the pre-ROC period, there were 56 investigators within the 10 participating sites which grew to 126 investigators by 2015. In the pre-ROC epoch of time (3 years) there were 418 total publications which increased to 1,558 by the 2013-2015 epoch. Conclusions: ROC helped facilitate collaboration resulting in an increase in both co-authored publications and network density that might not have existed without ROC. It also created a framework for interaction amongst investigators with shared clinical interests across multiple institutions.
Nanomaterials for modulating innate immune cells in cancer immunotherapy
Authors: Quoc-Viet Le, Geon Yang, Yina Wu, Ho Won Jang, Mohammadreza Shokouhimehr, Yu-Kyoung Oh
Journal: Asian Journal of Pharmaceutical Sciences (2018)

Cancer immunotherapy has been intensively investigated in both preclinical and clinical studies. Whereas chemotherapies use cytotoxic drugs to kill tumor cells, cancer immunotherapy is based on the ability of the immune system to fight cancer. Tumors are intimately associated with the immune system: they can suppress the immune response and/or control immune cells to support tumor growth. Immunotherapy has yielded promising results in clinical practice, but some patients show limited responses. This may reflect the complexities of the relationship between a tumor and the immune system. In an effort to improve the current immunotherapies, researchers have exploited nanomaterials in creating new strategies to cure tumors via modulation of the immune system in tumor tissues. Although extensive studies have examined the use of immune checkpoint-based immunotherapy, rather less work has focused on manipulating the innate immune cells. This review examines the recent approaches and challenges in the use of nanomaterials to modulate innate immune cells.
Abstract 12860: Enhanced Expression and PKCδ-mediated Hyperphosphorylation Underlie the Proarrhythmic Increase in Na+-Ca2+ Exchanger Activity in Patients With Chronic Atrial Fibrillation
Authors: Shokoufeh Ghezelbash, Cristina Espinosa Molina, Lina Badimon, Markus Kamler, Jordi Heijman, Dobromir Dobrev
Journal: Circulation (2016)

Background: Enhanced Na+-Ca2+ exchanger type-1 (NCX1) function is implicated in triggering and maintaining atrial fibrillation (AF), but the molecular mechanisms of dysfunctional NCX in AF patients...
Abstract 19990: High Intensity Statin Improves Survival in Kidney Transplant Patients
Authors: Arianne Clare Agdamag, Michael Lawrenz Co, Mita Zahra Co, Martin Hertl, Burhan Mohamedali
Journal: Circulation (2017)

Background: Both AHA and ACC have no established guidelines for statin therapy among kidney transplant (KT) patients. Guidelines from the Kidney Disease Improving Global Outcomes (KDIGO) recommend ...
Review: Immunotherapy improves some symptoms and reduces long-term medication use in mild to moderate asthma
Authors: Joy Lee, Christine McDonald
Journal: Annals of Internal Medicine (2018)

Source Citation Lin SY, Azar A, Suarez-Cuervo C, et al. The role of immunotherapy in the treatment of asthma. Comparative Effectiveness Review No. 196. AHRQ Publication No. 17(18)-EHC029-EF. Rockville, MD: Agency for Healthcare Research and Quality. March 2018.
Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
Authors: Kaiwen W. Chen, Mercedes Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D. Condon, Jessica B. von Pein, Petr Broz, Matthew J. Sweet, Kate Schroder
Journal: Science Immunology (2018)

Neutrophils form gasdermin D pores and expel antimicrobial neutrophil extracellular traps to defend against cytosolic bacteria.
Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness
Authors: Alex C. Spyropoulos, Walter Ageno, Gregory W. Albers, C. Gregory Elliott, Jonathan L. Halperin, William R. Hiatt, Gregory A. Maynard, P. Gabriel Steg, Jeffrey I. Weitz, Eunyoung Suh, Theodore E. Spiro, Elliot S. Barnathan, Gary E. Raskob
Journal: New England Journal of Medicine (2018)

Patients who are hospitalized for medical illness remain at risk for venous thromboembolism after discharge, but the role of extended thromboprophylaxis in the treatment of such patients is a subject of controversy.