tbuckley/cabot-search huggingface dataset:
Association of Cost Sharing With Use of Home Health Services Among Medicare Advantage Enrollees
Authors: Qijuan Li, Laura M. Keohane, Kali Thomas, Yoojin Lee, Amal N. Trivedi
Journal: JAMA Internal Medicine (2017)

<h3>Importance</h3> Several policy proposals advocate introducing copayments for home health care in the Medicare program. To our knowledge, no prior studies have assessed this cost-containment strategy. <h3>Objective</h3> To determine the association of home health copayments with use of home health services. <h3>Design, Setting, and Participants</h3> A difference-in-differences case-control study of 18 Medicare Advantage (MA) plans that introduced copayments for home health care between 2007 and 2011 and 18 concurrent control MA plans. The study included 135 302 enrollees in plans that introduced copayment and 155 892 enrollees in matched control plans. <h3>Exposures</h3> Introduction of copayments for home health care between 2007 and 2011. <h3>Main Outcomes and Measures</h3> Proportion of enrollees receiving home health care, annual numbers of home health episodes, and days receiving home health care. <h3>Results</h3> Copayments for home health visits ranged from $5 to $20 per visit, which were estimated to be associated with $165 (interquartile range [IQR], $45-$180) to $660 (IQR, $180-$720) in out-of-pocket spending for the average user of home health care. The increased copayment for home health care was not associated with the proportion of enrollees receiving home health care (adjusted difference-in-differences, −0.15 percentage points; 95% CI, −0.38 to 0.09), the number of home health episodes per user (adjusted difference-in-differences, 0.01; 95% CI, −0.01 to 0.03), and home health days per user (adjusted difference-in-differences, −0.19; 95% CI, −3.02 to 2.64). In both intervention and control plans and across all levels of copayments, we observed higher disenrollment rates among enrollees with greater baseline use of home health care. <h3>Conclusions and Relevance</h3> We found no evidence that imposing copayments reduced the use of home health services among older adults. More intensive use of home health services was associated with increased rates of disenrollment in MA plans. The findings raise questions about the potential effectiveness of this cost-containment strategy.
Pulmonary Embolism and Deep Venous Thrombosis in Patients Hospitalized With Syncope
Authors: Amol A. Verma, Hassan Masoom, Shail Rawal, Yishan Guo, Fahad Razak
Journal: JAMA Internal Medicine (2017)

This cross-sectional study examines how commonly patients hospitalized with syncope are investigated for pulmonary embolism or deep venous thrombosis in routine practice.
Hypoxia-inducible factor 2alpha drives the progression of experimental non-alcoholic fatty liver disease by stimulating hepatocyte production of histidine rich glycoprotein
Authors: E. Morello, S. Sutti, B. Foglia, S. Cannito, E. Novo, C. Bocca, S. Bruzzì, E. Bugianesi, E. Albano, M. Parola
Journal: Journal of Hepatology (2017)
Regional differences in the presentation and management of patients with hepatocellular carcinoma by liver disease etiology
Authors: N.G. Kim, M.-L. Yeh, J.D. Yang, J. Leong, M. Jun, W. Saeed, P. Nguyen, P.-C. Tsai, H.Y. Lee, C.-Y. Dai, J.-F. Huang, W.-L. Chuang, H.-I Yang, Y.-L. Chen, L. Roberts, M. Schwartz, D.W. Jun, Y.-S. Lim, M.-L. Yu, M.H. Nguyen
Journal: Journal of Hepatology (2017)
Clinical outcomes of patients delisted from the waiting list of liver transplantation after interferon-free antiviral therapy
Authors: J.M. Pascasio, C. Vinaixa, M.T. Ferrer, J. Colmenero, A. Rubin, L. Castells, M.L. Manzano, S. Lorente, M. Testillano, F.X. Xiol, E. Molina, L. Dominguez-Dieguez, E. Otón, S. Pascual, B. Santos, J.I. Herrero, M. Salcedo, J.L. Montero, G. Sánchez-Antolín, I. Narváez, F. Nogueras, A. Giráldez, X. Forns, M. Prieto, M.C. Londoño
Journal: Journal of Hepatology (2017)
Impact of natural killer cells receptors gene haplotypes on the development of hepatocarcinoma in cirrhotic patients
Authors: S. Onali, R. Littera, M. Casale, F. Capraro, F. Figorilli, C. Balestrieri, G. Serra, E. Congeddu, P. Ragatzu, R. Maddi, M. Serra, V. Loi, M. Trucas, C. Carcassi, L. Chessa
Journal: Journal of Hepatology (2017)
Irritability in Children and Adolescents
Authors: Melissa A. Brotman, Katharina Kircanski, Ellen Leibenluft
Journal: Annual Review of Clinical Psychology (2017)

Irritability is a common and impairing clinical presentation in children and adolescents. Despite its significant public health impact, irritability remains an elusive construct. Chronic and severe irritability is the primary symptom of the new DSM-5 diagnosis, disruptive mood dysregulation disorder (DMDD). However, empirical and clinical approaches to irritability are in their relative infancy, and questions regarding the validity of the DMDD diagnosis have been raised. Moreover, irritability is a trait distributed continuously in youth, thereby fitting within the National Institute of Mental Health Research Domain Criteria initiative. Thus, there are opportunities for scientific review and integration. Accordingly, the goals of this review include (a) clarifying the definitions of irritability, incorporating clinical and translational animal work; (b) reviewing the historical context surrounding the study of irritability; (c) reviewing the prevalence, clinical correlates, and longitudinal course of irritability; (d) presenting behavioral and neurobiological findings associated with irritability; and (e) exploring treatment options and proposing future directions for research.
Health-related quality of life questionnaires in bronchiectasis: the simplest way to quantify complexity
Authors: Casilda Olveira, Miguel Angel Martínez-García
Journal: European Respiratory Journal (2017)

The human mind is probably the most complex machine in the known universe. Billions of neuronal interconnections lead each individual to respond differently to a specific stimulus, but this response can quickly alter, and it can also be modulated by interaction between the individual's environment and the genetic load that he or she has inherited. Any precise quantification of all this information is still beyond our capabilities, but a concerted effort is underway to increase the number of objective measurements that could provide us with data about the severity and activity of diseases and bring us closer, sooner or later, to what has become known as personalised medicine [1]. Nevertheless, none of the objective measurements currently available are ideal for analysing the overall impact of a disease. The key questions in this respect are: How does each individual experience the disease, not merely from a physical viewpoint but also in psychological, social and spiritual terms? What factors modulate this response? How do these vary over time? Severity, activity and impact are three different dimensions of a disease and therefore they should never be confused. At present, a disease's impact on an individual is evaluated by means of health-related quality of life questionnaires [2], which are the best tools available for gleaning the maximum information about the complexities of such an impact while simplifying it as far as possible. This has led most regulatory bodies to insist on the inclusion of health-related quality of life as one of the main outcomes of clinical trials evaluating different therapeutic measures [3, 4]. Bronchiectasis Health Questionnaire is easy to use and suitable for evaluation of symptom-related quality of life <http://ow.ly/yjGY309YxRe>
Management of Chronic Pain in the Aftermath of the Opioid Backlash
Authors: Kurt Kroenke, Andrea Cheville
Journal: JAMA (2017)

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Pulmonary embolism following severe traumatic brain injury: incidence, risk factors and impact outcome
Authors: Mabrouk Bahloul, Hedi Chelly, Kais Regaieg, Nessrine Rekik, Samar Bellil, Anis Chaari, Wajdi Bouaziz, Imen Chabchoub, Sondes Haddar, Chokri Ben Hamida, Mounir Bouaziz
Journal: Intensive Care Medicine (2017)
Periodontitis is strongly associated with NAFLD in the NHANES III cohort and in an independent prospective study, is more common in those with biopsy-proven advanced compared to mild liver disease
Authors: W. Alazawi, D.F. Tai, P. Kemos, E. Bernabe, T. Janicki, D. Gillam, S. Samsuddin, W.K. Syn, W. Turner
Journal: Journal of Hepatology (2017)
Doxorubicin delivered by a redox-responsive dasatinib-containing polymeric prodrug carrier for combination therapy
Authors: Jingjing Sun, Yanhua Liu, Yichao Chen, Wenchen Zhao, Qianyu Zhai, Sanjay Rathod, Yixian Huang, Suoqin Tang, Yong Tae Kwon, Christian Fernandez, Raman Venkataramanan, Song Li
Journal: Journal of Controlled Release (2017)
Clinical characteristics and outcomes of elderly included in the Spanish Drug-Induced Liver Injury (DILI) Registry
Authors: M. Slim, J. Sanabria, M. Robles-Díaz, I. Medina-Cáliz, A. González-Jiménez, A. Ortega, M. García-Cortés, B. Garcia-Muñoz, R. Sanjuán-Jiménez, M.C. Fernandez, A. Castiella, E. Zapata, H. Hallal, E. Montane, G. Soriano, E. Roman, J.M. Navarro, M. Jimenez, M. Prieto, I. Conde, A. Aldea, M. Hernández-Guerra, J.M. Moreno, M. Romero-Gomez, E. Gomez-Dominguez, M.I. Lucena, R.J. Andrade
Journal: Journal of Hepatology (2017)
Subcategories of tendinopathy using ultrasound tissue characterization (utc): dorsal mid-portion achilles tendinopathy is more severe than ventral achilles tendinopathy
Authors: W Wynter Bee, J Ubhi, B Kumar
Journal: British Journal of Sports Medicine (2017)

To evaluate the association between tendon structure and clinical severity. Looking specifically at location of pathology, comparing ventral versus dorsal tendinopathy.
Ongoing measles outbreak in Wallonia, Belgium, December 2016 to March 2017: characteristics and challenges
Authors: Tine Grammens, Carole Schirvel, Sylvie Leenen, Nathalie Shodu, Veronik Hutse, Elise Mendes da Costa, Martine Sabbe
Journal: Eurosurveillance (2017)

We describe characteristics of an ongoing measles outbreak in Wallonia, Belgium, and difficulties in control measures implementation. As at 12 March 2017, 177 measles cases were notified, of which 50% were 15 years and older, 49% female. Atypical clinical presentation and severe complications, mainly among adults, in combination with late notification, low or unknown vaccination coverage of contacts, infected healthcare workers and increased workload due to contact tracing, are the main concerns for outbreak management.
Time in HE in cirrhotic patients with an acute episode (≥grade 2) determines short and long-term survival
Authors: M.V. Cots, I. Carmona, C. Moreno, J. Ampuero, M. Simon-Talero, F. Sanpedro, I. Les, M. Romero-Gomez, J. Genescà
Journal: Journal of Hepatology (2017)
Combination of long term N-Acetylcysteine and Ursodeoxycolic Acid in NASH: a multicenter randomized control trial
Authors: C.P. Oliveira, H.P. Cotrim, A. Cristina, G. Siqueira, A.L.A. Salgado, J.T. Stefano, P. Brizolla, L. Mattos, A.H.B. Martins, A.R. Andrade, R. Sciuto, L.A. Freitas, V.A.F. Alves, F.J. Carrilho, E.R. Parise
Journal: Journal of Hepatology (2017)
Antiviral activity of GS-5801, a liver-targeted prodrug of a lysine demethylase 5 inhibitor, in a hepatitis B virus primary human hepatocyte infection model
Authors: S. Gilmore, D. Tam, R. Dick, T. Appleby, G. Birkus, M. Willkom, W.E. Delaney, G.T. Notte, B. Feierbach
Journal: Journal of Hepatology (2017)
Costs of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients with Acute Lymphoblastic Leukemia (ALL) - an Analysis of German Claims Data
Authors: Moritz Lehne, Lennart Hickstein, Tayyab Salimullah, Jun Su, Sigurd Prieur, Simu K Thomas
Journal: Blood (2016)
CC-122 Is a Cereblon Modulating Agent That Is Active in Lenalidomide-Resistant and Lenalidomide/Dexamethasone-Double-Resistant Multiple Myeloma Pre-Clinical Models
Authors: Chad C Bjorklund, Jian Kang, Ling Lu, Michael Amatangelo, Hsiling Chiu, Patrick Hagner, Anita K. Gandhi, Michael Pourdehnad, Anke Klippel, Anjan Thakurta
Journal: Blood (2016)
Abstract P214: Mediterranean Diet, Vegetable-based Dietary Patterns and Diet Quality are Associated With Higher Resilience: Findings From the Moli-sani Study
Authors: Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Amalia De Curtis, George Pounis, Mariarosaria Persichillo, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Journal: Circulation (2017)

Introduction: Resilience is a measure of stress coping ability and has been favourably associated with cardiovascular health. Yet little is known on the likely association between diet and resilience. Hypothesis: We tested the hypothesis that diet quality is associated with resilience. Methods: Cross-sectional analysis on 10,812 subjects (mean age 52.7±10.8, 50.5% men) recruited within the cohort of the Moli-sani study from 2005 to 2010. Resilience was measured by the 25-item Connor-Davidson Resilience Scale ranging from 0-100 with the higher score reflecting greater resilience. Food intake was recorded by the EPIC food frequency questionnaire and adherence to the Mediterranean diet was appraised by both a Greek and an Italian dietary score. Empirically-derived dietary patterns were obtained by principal components analysis (PCA), while dietary polyphenol and antioxidant intakes and fruit and vegetables variety were assessed by specific holistic scoring. Multivariable linear regression analysis (95%CI) was used to test the association between dietary scores and resilience. Results: As compared to those below the median value of resilience (score=67), more resilient subjects had higher educational status (19.4% vs 13.5% for university or postgraduate education) and were more likely to report favourable health behaviours (leisure-time physical activity and less prevalence of smoking habit) . In a multivariable model, greater adherence to Mediterranean-type diets or vegetables-based dietary pattern obtained from PCA, as well as dietary polyphenol or antioxidant intakes and greater variety in fruit and vegetables consumption were all positively associated with resilience (Table) . No association with Western-like diets was found. Conclusions: Diet quality, as measured by a number of dietary scores, was positively associated with higher resilience, whereas western-type diets were not. Modulation of stress coping ability may be a factor in considering healthy effect of high quality diet.
Cathepsin Z variants are associated with progression to end-stage hepatic failure in Japanese patients with primary biliary cholangitis
Authors: N. Nishida, Y. Aiba, Y. Hitomi, M. Kawashima, H. Nakamura, N. Yamashiki, T. Tanaka, S. Tamura, A. Mori, S. Yagi, Y. Soejima, K. Shirabe, A. Tanaka, K. Harada, S. Shimoda, A. Komori, Y. Maehara, S. Uemoto, N. Kokudo, K. Tokunaga, M. Nakamura
Journal: Journal of Hepatology (2017)
The misleading effect of serum galactomannan testing in high-risk haematology patients receiving prophylaxis with micafungin
Authors: A. Vena, E. Bouza, A. Álvarez-Uría, J. Gayoso, P. Martín-Rabadán, F. Cajuste, J. Guinea, J. Gómez Castellá, R. Alonso, P. Munoz
Journal: Clinical Microbiology and Infection (2017)
Significantly lower rates of cirrhosis and worse long-term survival in cryptogenic hepatocellular carcinoma compared to viral etiologies: results of a multi-center international cohort
Authors: T. Jun, M.-L. Yeh, V. Chen, J.D. Yang, P. Nguyen, M. Chung, G. Nasra, C.F. Huang, C.-Y. Dai, J.-F. Huang, W.-L. Chuang, L. Roberts, M. Nguyen, M.-L. Yu
Journal: Journal of Hepatology (2017)
Abstract 254: Losartan Improves Disease Outcome in a Double-Mutant Model of Severe Hypertrophic Cardiomyopathy
Authors: Rhian E Shephard, Tatiana Tsoutsman, Richard D Bagnall, William Ritchie, Christopher Semsarian
Journal: Circulation Research (2012)

INTRODUCTION: Hypertrophic cardiomyopathy (HCM) is an inherited disease of the myocardium, caused by sarcomere mutations. Multiple causal mutations in HCM patients correlates with disease severity, including increased LV hypertrophy, early disease onset and elevated incidence of sudden cardiac death events. There are currently no pharmacological therapies that have definitively been shown to prevent or cause regression of HCM. OBJECTIVE: To investigate losartan as a preventative therapy in a severe mouse model of HCM. METHODS: This study used the TnI-203/MHC-403 mouse model, which expresses two HCM-causing mutations resulting in severe disease phenotype and 100% mortality by 21 days. This model recapitulates a subgroup of HCM patients who progress to a dilated phenotype and heart failure. TnI-203/MHC-403 and non-transgenic mice were treated with losartan or water from a pre-disease time-point. Measures of outcome included survival analysis, cardiac function, whole heart morphology, fibrosis and hypertrophy. miRNA and mRNA profiling was performed on ventricle RNA of the TnI-203/MHC-403 mice, and miRNAs with modified expression were cross-referenced to predicted, differentially expressed target mRNAs. RESULTS: Losartan treatment improved disease outcome in the TnI-203/MHC-403 mice, including increased survival by 35% (mean, 23.3±1.4 days vs 17.3±6 days; P&lt;0.0001), improved cardiac function (fractional shortening, 54±4% vs 40±14%, P&lt;0.01), normalized gross heart morphology and heart-weight:body-weight ratios, decreased interstitial fibrosis at 14 days (0.84±0.12% vs 7.81±2.25%, P&lt;0.01) and 17 days (2.30±0.36% vs 8.98±1.73%, P&lt;0.0001), and reduced expression of pro-fibrotic- and pro-hypertrophic- molecules. Expression profiling showed six miRNAs (miR-30c, miR-203, miR-21, miR-214, miR-31, miR-199a-3p) were significantly altered with treatment, and their predicted targets within the differentially expressed mRNAs were identified. CONCLUSION: Early treatment with losartan improves disease outcome in this double-mutant mouse model of severe HCM. miRNAs that play a potentially beneficial role in this improvement, have been identified and may be promising as new therapeutic targets.
Platelet desialylation is a novel mechanism and a therapeutic target in thrombocytopenia during sepsis: an open-label, multicenter, randomized controlled trial
Authors: Mei-feng Li, Xiao-li Li, Kai-liang Fan, Ying-yi Yu, Jing Gong, Shu-ying Geng, Ya-feng Liang, Ling Huang, Ji-hua Qiu, Xing-han Tian, Wen-ting Wang, Xiao-lu Zhang, Qing-xia Yu, Yuan-feng Zhang, Peng Lin, Li-na Wang, Xin Li, Ming Hou, Lu-yi Liu, Jun Peng
Journal: Journal of Hematology & Oncology (2017)

Studies in murine models suggested that platelet desialylation was an important mechanism of thrombocytopenia during sepsis. First, we performed a prospective, multicenter, observational study that enrolled septic patients with or without thrombocytopenia to determine the association between platelet desialylation and thrombocytopenia in patients with sepsis, severe sepsis, and septic shock. Gender- and age-matched healthy adults were selected as normal controls in analysis of the platelet desialylation levels (study I). Next, we conducted an open-label randomized controlled trial (RCT) in which the patients who had severe sepsis with thrombocytopenia (platelet counts ≤50 × 109/L) were randomly assigned to receive antimicrobial therapy alone (control group) or antimicrobial therapy plus oseltamivir (oseltamivir group) in a 1:1 ratio (study II). The primary outcomes were platelet desialylation level at study entry, overall platelet response rate within 14 days post-randomization, and all-cause mortality within 28 days post-randomization. Secondary outcomes included platelet recovery time, the occurrence of bleeding events, and the amount of platelets transfused within 14 days post-randomization. The platelet desialylation levels increased significantly in the 127 septic patients with thrombocytopenia compared to the 134 patients without thrombocytopenia. A platelet response was achieved in 45 of the 54 patients in the oseltamivir group (83.3%) compared with 34 of the 52 patients in the control group (65.4%; P = 0.045). The median platelet recovery time was 5 days (interquartile range 4–6) in the oseltamivir group compared with 7 days (interquartile range 5–10) in the control group (P = 0.003). The amount of platelets transfused decreased significantly in the oseltamivir group compared to the control group (P = 0.044). There was no difference in the overall 28-day mortality regardless of whether oseltamivir was used. The Sequential Organ Failure Assessment score and platelet recovery time were independent indicators of oseltamivir therapy. The main reason for all of the mortalities was multiple-organ failure. Thrombocytopenia was associated with increased platelet desialylation in septic patients. The addition of oseltamivir could significantly increase the platelet response rate, shorten platelet recovery time, and reduce platelet transfusion. Chinese Clinical Trial Registry, ChiCTR-IPR-16008542 .
Evaluation of cytochrome P450- and transporter-mediated drug-drug interactions with the farnesoid x receptor agonist GS-9674 and phenotypic probe substrates and inhibitors/inducers
Authors: C.H. Nelson, B.J. Kirby, N. Lu, C.S. Djedjos, R.P. Myers, D. Xiao, C. Swartzburg, A. Mathias
Journal: Journal of Hepatology (2017)