tbuckley/cabot-search huggingface dataset:
Endoscopic necrosectomy through a lumen-apposing metal stent resulting in perforation: is it time to develop dedicated accessories?
Authors: Mihai Rimbaș, Gianenrico Rizzati, Antonio Gasbarrini, Guido Costamagna, Alberto Larghi
Journal: Endoscopy (2017)

A novel lumen-apposing self-expandable metal stent (LAMS; Axios EC; Boston Scientific Corp., Marlborough, Massachusetts, USA) that is able to create a stable communicating fistulous tract has simplified the performance of endoscopic necrosectomy for walled-off pancreatic necrosis (WOPN).
Brotes de infecciones por E. coli O157 en el suroeste del Reino-Unido : riesgos asociados con los arroyos que atraviesan las playas
Authors: C Ihekweazu, M Barlow, S Roberts, H Christensen, B Guttridge, D A Lewis, S Painter
Journal: Eurosurveillance (2006)

En agosto de 2004, fueron identificados siete casos de infecciones por Escherichia coli O157 en ninos de vacaciones en Cornwall, en el suroeste de Inglaterra. Cada nino se habia alojado en distintos sitios de la region. Los aislamientos de los siete casos dieron positivo para E. coli de serogrupo O157 y de fagotipo 21/28. Se llevo a cabo un estudio caso-control entre las personas que habian pasado sus vacaciones en esa playa. Se realizaron encuestas telefonicas a los padres. Estos cuestionarios incluian preguntas sobre la playa donde jugaban sus ninos, si habian tenido contacto con el arroyo que atravesaba la playa, donde compraban su comida y la origen de los alimentos consumidos. Los ninos casos habian jugado mas en el agua del arroyo que los controles (OR [1.72- no definido]). El tiempo pasado en el arroyo por los casos era el doble del de los controles. Los casos y los controles tenian la misma exposicion a los otros factores de riesgo. Los perfiles de electroforesis en campo pulsado de todos los casos eran identicos. Antes del inicio del brote se habia detectado un aumento del numero coliformes en el arroyo. Se descubrio que habia ganado pastando rio arriba. Sugerimos que el vehiculo del infeccion para este brote de gastroenteritis aguda por E. coli O157 fue el arroyo contaminado que corria hacia el mar en esa playa. Las fuertes lluvias de los dias precedentes podian haber arrastrado hacia el arroyo heces del ganado potencialmente contaminadas con E. coli O157. Las medidas de control adoptadas fueron el vallado de la parte del arroyo donde jugaban los ninos y la colocacion de carteles de advertencia a lo largo de la playa.
The Paleo-Indian Entry into South America According to Mitogenomes
Authors: Stefania Brandini, Paola Bergamaschi, Marco Fernando Cerna, Francesca Gandini, Francesca Bastaroli, Emilie Bertolini, Cristina Cereda, Luca Ferretti, Alberto Gómez-Carballa, Vincenza Battaglia, Antonio Salas, Ornella Semino, Alessandro Achilli, Anna Olivieri, Antonio Torroni
Journal: Molecular Biology and Evolution (2017)

Recent and compelling archaeological evidence attests to human presence ∼14.5 ka at multiple sites in South America and a very early exploitation of extreme high-altitude Andean environments. Considering that, according to genetic evidence, human entry into North America from Beringia most likely occurred ∼16 ka, these archeological findings would imply an extremely rapid spread along the double continent. To shed light on this issue from a genetic perspective, we first completely sequenced 217 novel modern mitogenomes of Native American ancestry from the northwestern area of South America (Ecuador and Peru); we then evaluated them phylogenetically together with other available mitogenomes (430 samples, both modern and ancient) from the same geographic area and, finally, with all closely related mitogenomes from the entire double continent. We detected a large number (N = 48) of novel subhaplogroups, often branching into further subclades, belonging to two classes: those that arose in South America early after its peopling and those that instead originated in North or Central America and reached South America with the first settlers. Coalescence age estimates for these subhaplogroups provide time boundaries indicating that early Paleo-Indians probably moved from North America to the area corresponding to modern Ecuador and Peru over the short time frame of ∼1.5 ka comprised between 16.0 and 14.6 ka.
TCT-382 Four-Year Outcomes with the Fully Repositionable and Retrievable Lotus Transcatheter Aortic Valve: Results from the REPRISE II Study
Authors: David Hildick-Smith, Darren Walters, Nicolas Dumonteil, Stephen G. Worthley, Didier Tchetche, Ganesh Manoharan, Daniel Blackman, Gilles Rioufol, Robert Whitbourn, Thierry Lefevre, Ruediger Lange, Ralf Mueller, Simon Redwood, Dominic Allocco, Ian Meredith
Journal: Journal of the American College of Cardiology (2017)
TCT-777 Usefulness of Sinus of Valsalva diameter measurement for sizing the valve in transcatheter aortic valve replacement
Authors: Hector Crespo, Roberto J. Cubeddu, Gianina Flocco, Andres Carmona, Mark Rothenberg, Lawrence Lovitz, George Daniels, Eric Heller, Lance Lester, Marcos Nores
Journal: Journal of the American College of Cardiology (2017)
TCT-392 Beyond door-to-balloon time in primary PCI: First medical contact-to-first device time of less than 120 minutes is a reasonable contemporary real-world prognostic target
Authors: Peter Moore, Yash Singbal, Jillian Milne, Thomas Rosenfeld, Deepu Balakrishnan, Katherine Pemberton, Emma Bosley, Richard Lim
Journal: Journal of the American College of Cardiology (2017)
Infecciones por Hantavirus en Finlandia
Authors: O Vapalahti, A Vaheri, H Henttonen
Journal: Eurosurveillance (1995)

Los Hantavirus causan fiebre hemorragica con sindrome renal (FHSR) yneumonias por Hantavirus (SPH), han sido diagnosticadas en el mundo entero (1).El virus se transmite a los humanos por inhalacion de secreciones deroedores.
Épidémie à Salmonella Typhimurium DT 104A, associée au salami traditionnel en Italie, à Pâques
Authors: I Luzzi, P Galetta, M Massari, Caterina Rizzo, A M Dionisi, E Filetici, A Cawthorne, A Tozzi, M Argentieri, S Bilei, L Busani, C Gnesivo, A Pendenza, A Piccoli, P Napoli, L Loffredo, M O Trinito, E Santarelli, M L Ciofi Degli Atti
Journal: Eurosurveillance (2007)

Salmonella enterica est couramment mise en cause dans les maladies gastro-intestinales en Italie. S. Typhimurium represente environ 40 % des isolats, dont la plupart des souches appartiennent au type DT104. Nous decrivons ici les investigations menees lors de l’apparition de S. Typhimurium DT104A, un sous-type jamais observe auparavant en Italie, a Rome au cours du printemps 2004.
Government is warned over “serious” risks to NHS this winter
Authors: Jacqui Thornton
Journal: BMJ (2017)

Meg Hillier, chair of the House of Commons Public Accounts Committee, has warned the government of the serious potential risks of pressures in the NHS this winter, despite the Department of Health’s reassurances of better planning.

Hillier, the Labour MP for Hackney South and Shoreditch, wrote to Chris Wormald, permanent secretary of the Department of Health, after an oral evidence session on 16 October, saying it was a “worrying time for already overstretched services.”

Hillier, who has chaired the committee since 2015, said that Wormald had acknowledged that more remains to be done to put the NHS in England on a sustainable …
HIV Infection Manifesting as Proximal White Onychomycosis
Authors: Elisabeth Gómez-Moyano, Vicente Crespo-Erchiga
Journal: New England Journal of Medicine (2017)

A 48-year-old-man presented with whitish discoloration and hyperkeratosis of the toenail that had extended quickly from the proximal to the distal nail fold. This atypical presentation of onychomycosis prompted investigation for underlying immunosuppression.
Focal Pulmonary Uptake on 99mTc-Sestamibi Parathyroid Scintigraphy Due to Iatrogenic Microembolism
Authors: Ying Kou, Guohua Shen, Xiaohong Ou, Rui Huang, Anren Kuang
Journal: Clinical Nuclear Medicine (2017)

A middle-aged woman underwent Tc-sestamibi parathyroid scintigraphy because of parathyroid disease, and a focal pulmonary uptake of Tc-sestamibi was incidentally found on both planar and SPECT/CT images without corresponding pulmonary abnormality on the CT images. After 10 days, a subsequent parathyroid scintigraphy revealed no pulmonary accumulation. Therefore, the pulmonary intense Tc-sestamibi focus that once appeared in the first scan might be an artifact of iatrogenic microembolism from injection site.
Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014
Authors: Kalyani Sonawane, Ryan Suk, Elizabeth Y. Chiao, Jagpreet Chhatwal, Peihua Qiu, Timothy Wilkin, Alan G. Nyitray, Andrew G. Sikora, Ashish A. Deshmukh
Journal: Annals of Internal Medicine (2017)

Background: The burden of human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma (OPSCC) is disproportionately high among men, yet empirical evidence regarding the difference in prevalence of oral HPV infection between men and women is limited. Concordance of oral and genital HPV infection among men is unknown. Objective: To determine the prevalence of oral HPV infection, as well as the concordance of oral and genital HPV infection, among U.S. men and women. Design: Nationally representative survey. Setting: Civilian noninstitutionalized population. Participants: Adults aged 18 to 69 years from NHANES (National Health and Nutrition Examination Survey), 2011 to 2014. Measurements: Oral rinse, penile swab, and vaginal swab specimens were evaluated by polymerase chain reaction followed by type-specific hybridization. Results: The overall prevalence of oral HPV infection was 11.5% (95% CI, 9.8% to 13.1%) in men and 3.2% (CI, 2.7% to 3.8%) in women (equating to 11 million men and 3.2 million women nationwide). High-risk oral HPV infection was more prevalent among men (7.3% [CI, 6.0% to 8.6%]) than women (1.4% [CI, 1.0% to 1.8%]). Oral HPV 16 was 6 times more common in men (1.8% [CI, 1.3% to 2.2%]) than women (0.3% [CI, 0.1% to 0.5%]) (1.7 million men vs. 0.27 million women). Among men and women who reported having same-sex partners, the prevalence of high-risk HPV infection was 12.7% (CI, 7.0% to 18.4%) and 3.6% (CI, 1.4% to 5.9%), respectively. Among men who reported having 2 or more same-sex oral sex partners, the prevalence of high-risk HPV infection was 22.2% (CI, 9.6% to 34.8%). Oral HPV prevalence among men with concurrent genital HPV infection was 4-fold greater (19.3%) than among those without it (4.4%). Men had 5.4% (CI, 5.1% to 5.8%) greater predicted probability of high-risk oral HPV infection than women. The predicted probability of high-risk oral HPV infection was greatest among black participants, those who smoked more than 20 cigarettes daily, current marijuana users, and those who reported 16 or more lifetime vaginal or oral sex partners. Limitation: Sexual behaviors were self-reported. Conclusion: Oral HPV infection is common among U.S. men. This study's findings provide several policy implications to guide future OPSCC prevention efforts to combat this disease. Primary Funding Source: National Cancer Institute.
Autophagy Maintains the Function of Bone Marrow Mesenchymal Stem Cells to Prevent Estrogen Deficiency-Induced Osteoporosis
Authors: Meng Qi, Liqiang Zhang, Yang Ma, Yi Shuai, Liya Li, Kefu Luo, Wenjia Liu, Yan Jin
Journal: Theranostics (2017)

Rationale: The impaired function of endogenous bone marrow mesenchymal stem cells (BMMSCs) is a determinant in the development of osteoporosis (OP). Recent researches have proved that autophagy plays an important role in maintenance of skeletal phenotype. However, whether autophagy affects the development of OP through regulating the function of BMMSCs remains elusive. Methods: Ovariectomy (OVX)-induced OP model and sham model were established in 8-week-old C57 mice. The differentiation and immunoregulation properties of BMMSCs from two models were examined by osteogenic/adipogenic induction in vitro and treatment of a dextran sulfate sodium (DSS)-induced mice colitis model in vivo. We evaluated autophagy activity in sham and OVX BMMSCs by quantitative real time-polymerase chain reaction (qRT-PCR), western blotting, laser confocal microscopy and transmission electron microscopy (TEM). Finally, to testify the effects of rapamycin, short hairpin RNA (shRNA) -BECN1 (shBECN1) and shRNA-ATG5 (shATG5), we performed Alizarin Red staining and Oil Red O staining to detect lineage differentiations of BMMSCs, and carried out micro-CT, calcein staining and Oil Red O staining to assess the skeletal phenotype. Results: BMMSCs from OVX-induced OP model mice exhibited decreased osteogenic differentiation, increased adipogenic differentiation and impaired immunoregulatory capacity. Furthermore, autophagy decreased both in bone marrow and BMMSCs of osteoporotic mice. Importantly, regulation of autophagy directly affects the functions of BMMSCs, including differentiation and immunoregulatory capacities. Moreover, treatment with rapamycin rescued the function of endogenous BMMSCs and attenuated the osteoporotic phenotype in OVX mice. Conclusion: Our findings suggest that autophagy regulates the regenerative function of BMMSCs and controls the development of OP. The restoration of autophagy by rapamycin may provide an effective therapeutic method for osteoporosis.
Differentiation between various Chondroitin sulfate formulations in symptomatic knee osteoarthritis
Authors: Jean Yves Reginster
Journal: Annals of the Rheumatic Diseases (2017)

We are very grateful to Professor Lee1 for his senseful comments regarding our recently published paper showing that pharmaceutical-grade chondroitin sulfate is superior to placebo and similar to celecoxib in reducing pain and improving function in patients with knee osteoarthritis.2 We fully …
Abstract 18163: A Prospective Study of Fatty Liver Index and Incident Hypertension
Authors: Jangyoung Kim, Junwon Lee, Young Jin Youn, Min Su Ahn, Byung Su Yoo, Seung Hwan Lee, Junghan Yoon
Journal: Circulation (2015)

Background: Although non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood. Hypothesis: We investigated whether fatty liver disease, as assessed by the fatty liver index (FLI), could predict the development of hypertension independently of systemic insulin resistance and inflammatory status. Methods: Prospective cohort study of 1,521 adults (484 men and 1037 women) aged 40 to 70 years without baseline hypertension examined in 2005 to 2008 as a baseline and 2008 to 2011 for follow-up. An equation was used to calculate FLI and classify patients as follows: FLI&lt;30, no NAFLD; FLI ≥60, NAFLD; and 31&lt;FLI&lt;59, intermediate FLI. Results: During an average of 2.6 years of follow-up, 153 subjects (10.06 %) developed hypertension. FLI was positively associated with baseline blood pressure, homeostasis model assessment of insulin resistance (HOMA-IR), leptin, urinary albumin/creatinine excretion, and high sensitivity C-reactive protein (hsCRP). After adjustment for confounding factors, including markers of insulin resistance and systemic inflammation, the odds ratio (95% confidence interval) for the incident hypertension increased in a graded manner with FLI (&lt;30 vs. 30-59 vs. ≥60= 1 vs. 1.77 [1.16-2.71] vs. 2.06 [1.09-3.89], respectively). Conclusions: NAFLD assessed by FLI was an independent risk factor for hypertension. Our findings suggest that FLI, a simple surrogate indicator of fatty liver disease, might be useful for identifying subjects at high risk for incident hypertension in clinical practice.
Segregated Systems of Human Brain Networks
Authors: Gagan S. Wig
Journal: Trends in Cognitive Sciences (2017)

The organization of the brain network enables its function. Evaluation of this organization has revealed that large-scale brain networks consist of multiple segregated subnetworks of interacting brain areas. Descriptions of resting-state network architecture have provided clues for understanding the functional significance of these segregated subnetworks, many of which correspond to distinct brain systems. The present report synthesizes accumulating evidence to reveal how maintaining segregated brain systems renders the human brain network functionally specialized, adaptable to task demands, and largely resilient following focal brain damage. The organizational properties that support system segregation are harmonious with the properties that promote integration across the network, but confer unique and important features to the brain network that are central to its function and behavior.
Life-Threatening Complication after Right Renal Extracorporeal Shock Wave Lithotripsy: Large Hepatic Haematoma Requiring Embolisation of the Right Hepatic Artery
Authors: Josef Beatrice, Raeto T. Strebel, Thomas Pfammatter, Jaime H. Röhweder, Tullio Sulser
Journal: European Urology (2007)
Intranasal administration of allergen increases specific IgE whereas intranasal omalizumab does not increase serum IgE levels—A pilot study
Authors: J. Eckl‐Dorna, R. Fröschl, C. Lupinek, R. Kiss, P. Gattinger, K. Marth, R. Campana, I. Mittermann, K. Blatt, P. Valent, R. Selb, A. Mayer, K. Gangl, I. Steiner, J. Gamper, T. Perkmann, P. Zieglmayer, P. Gevaert, R. Valenta, V. Niederberger
Journal: Allergy (2017)

Abstract Background Administration of the therapeutic anti‐IgE antibody omalizumab to patients induces strong increases in IgE antibody levels. Objective To investigate the effect of intranasal administration of major birch pollen allergen Bet v 1, omalizumab or placebo on the levels of total and allergen‐specific IgE in patients with birch pollen allergy. Methods Based on the fact that intranasal allergen application induces rises of systemic allergen‐specific IgE, we performed a double‐blind placebo‐controlled pilot trial in which birch pollen allergic subjects were challenged intranasally with omalizumab, placebo or birch pollen allergen Bet v 1. Total and allergen‐specific IgE, IgG and basophil sensitivity were measured before and 8 weeks after challenge. For control purposes, total, allergen‐specific IgE levels and omalizumab‐IgE complexes as well as specific IgG levels were studied in subjects treated subcutaneously with either omalizumab or placebo. Effects of omalizumab on IgE production by IL ‐4/anti‐ CD 40‐treated PBMC s from allergic patients were studied in vitro. Results Intranasal challenge with Bet v 1 induced increases in Bet v 1‐specific IgE levels by a median of 59.2%, and this change differed significantly from the other treatment groups ( P = .016). No relevant change in allergen‐specific and total IgE levels was observed in subjects challenged with omalizumab. Addition of omalizumab did not enhance IL ‐4/anti‐ CD 40‐induced IgE production in vitro. Significant rises in total IgE (mean IgE before: 131.83 kU /L to mean IgE after: 505.23 kU /L) and the presence of IgE‐omalizumab complexes were observed after subcutaneous administration of omalizumab. Conclusion Intranasal administration of allergen induced rises of allergen‐specific IgE levels, whereas intranasal administration of omalizumab did not enhance systemic total or allergen‐specific IgE levels.
Surto de Febre Q em Lohra-Rollshausen, Alemanha, Primavera de 1996
Authors: O Lyytikaïnen, T Ziese, B Schwartländer, P Matzdorff, C Kuhnhen, C Burger, W Krug, L R Petersen
Journal: Eurosurveillance (1997)

A febre Q e uma doenca febril aguda (por vezes cronica), causada pela rickettsia Coxiella burnetii. Os reservatorios animais mais correntes para a C. burnetii sao os bovinos, ovinos e caprinos. Os animais infectados albergam o organismo, que resiste a dessecacao, especialmente em produtos do parto. Os humanos sao infectados principalmente pela inalacao de poeiras e aerossois contaminados (1). Em Maio de 1996, o servico de saude de Marburg-Biedenkopf em Hessen foi informado dum aglomerado de doentes com febre elevada e persistente, em Rollshausen e nas vilas proximas. As analises serologicas, efectuadas pelas autoridades de saude locais, a alguns doentes sugeriram que os mesmos tinham tido febre Q. Em Julho de 1996, o Instituto Robert Koch foi solicitado a participar na investigacao deste aglomerado a fim de verificar se tinha havido realmente um surto de febre Q, em Rollshausen e de avaliar os potenciais factores de risco para a febre Q.
TCT-202 Evaluation of Renal Function Improvement After Transcatheter Aortic Valve Replacement
Authors: Michel Lemes da Silva, Antonio Carlos Bacelar Nunes Filho, Adriano Caixeta, Henrique Ribeiro, Natalia Esteves, Breno Almeida, Jose Mariani, Carlos Campos, Carolina Pereira, Rogério Ruscitto Prado, Marcelo Franken, Flávio Tarasoutchi, Pedro A. Lemos, Fabio Brito
Journal: Journal of the American College of Cardiology (2017)
Le botulisme par blessure chez les utilisateurs de drogues injectables: forte progression du nombre de cas en Angleterre en 2004
Authors: D Akbulut, J Dennis, M Gent, K A Grant, V Hope, C Ohai, J McLauchlin, V Mithani, O Mpamugo, F Ncube, L De Souza-Thomas
Journal: Eurosurveillance (2005)

Le botulisme par blessure du a Clostridium botulinum n’etait pas reconnue au Royaume-Uni et en Irlande avant 2000. C. botulinum produit une neurotoxine puissante qui peut entrainer une paralysie et la mort. Dix cas ont ete identifies cliniquement en 2000 et 2001, et respectivement 23 et 40 cas en 2002 et 2004. Tous les cas etaient des heroinomanes par voie injectable. Soixante-dix cas sont survenus en Angleterre ; les autres sont survenus en Ecosse (12 cas), au Pays de Galles (2 cas) et en Republique d’Irlande (4 cas). Au total, 40 cas sur 88 (45%) ont ete confirmes microbiologiquement par detection serologique de la toxine botulinique ou par isolement de C. botulinum dans les plaies. Sur les 40 cas de 2004, 36 sont survenus en Angleterre, et sur les 12 prelevements confirmes microbiologiquement, 10 etaient de type A. En 2004, certains cas etaient groupes geographiquement, la plupart sont survenus a Londres et au nord-est de l’Angleterre, dans la region du Yorkshire et Humberside.