tbuckley/cabot-search huggingface dataset:
A Cascade‐Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition
Authors: Xilong Wu, Yundi Wu, Zhiyong Wang, Lixin Liu, Chengxin Sun, Yongming Chen, Chun Wang
Journal: Advanced Healthcare Materials (2018)

Abstract Autophagy is a homeostatic lysosome‐dependent metabolic process to eliminate damaged or dysfunctional cellular organelles, which is closely associated with tumor progression. Indocyanine green (ICG) can convert NIR light energy to localized heat for cancer cell and tissue ablation. However, the effect of autophagy modulation on ICG‐mediated photothermal therapy remains unknown. In this study, it is found that primaquine (PQ) suppresses autophagy flux at a late stage through the impeding fusion of the autophagosome with the lysosome to form an autophagolysosome, leading to cell apoptosis or necrosis. This autophagosome–lysosome fusion inhibitory effect and the autophagosome accumulation are more evident in the photothermal therapy combined with autophagy inhibition. Motivated by this notable effect, a cascade‐targeting nanocapsule (HCP) is constructed using an organic solvent‐free strategy to coencapsulate PQ and ICG. By targeting the cluster designation 44 molecule and sequentially enhancing the cell‐penetrating peptide‐mediated endocytosis, the codelivery of PQ/ICG by HCP achieves selective recognition and reinforces the internalization by MCF‐7 cells to exert a synergistic therapeutic effect on MCF‐7 cells both in vitro and in vivo. The HCP system for the photothermal and autophagy inhibition combination therapy represents a novel strategy for the treatment of breast cancer.
EUS Guided natural orifice tranvisceral endoscopic surgical (NOTES) approach to retroperitoneum
Authors: A Chak, M McGee, J Marks, A Faulx, R Onders, S Schomisch, J Ponsky
Journal: Endoscopy (2006)

Background: To date, novel NOTES techniques have primarily addressed organs in the peritoneal cavity. NOTES approaches to the retroperitoneum could lead to novel diagnostic and therapeutic approaches to pancreatic diseases. AIM: To evaluate the feasibility and develop EUS guided NOTES techniques to access the pancreas. Methods: EUS guided NOTES access through the posterior gastric wall was attempted in 5 pigs. Different access techniques were tested using a curvilinear array echoendoscope. The techniques were further modified based on experience. In technique 1, the pancreas was identified by EUS and a needle knife was used to create a freehand gastrotomy. In technique 2, a 22 gauge EUS-FNA needle was used to penetrate the gastric wall and inject a 30 cc cushion of fluid prior to a free hand needle knife gastrotomy. In technique 3, a 19 gauge EUS-FNA needle was used to penetrate the gastric wall, inject a fluid cushion, pass a guidewire, followed by enlargement of the tract with electrocautery and balloon dilation. Success was subsequently assessed by performing open laparotomy and examining the NOTES gastrotomy and retroperitoneal area. Results: All 3 approaches succeeded in EUS guided posterior gastrotomies. Only technique 3 provided directed entry, confirmed by India ink injected at time of NOTES access. Technique 1 was of limited utility because of the inability to control depth of puncture and avoid thermal injury. Both techniques 1 and 2 resulted in peritoneal entry despite a successful posterior gastrotomy, partially related to the pig stomach, which rotates freely. Conclusions: EUS-FNA guided transgastric fluid injection followed by tract dilation over a guide-wire was the most promising NOTES approach to the retroperitoneum. EUS specific accessories that can penetrate the gastric wall more perpendicularly and successful gastrotomy closure techniques need to be developed.
MODIFIED FULLY COVERED SELF-EXPANDABLE METAL STENT VERSUS PLASTIC STENT FOR PREOPERATIVE BILIARY DRAINAGE IN PATIENTS WITH RESECTABLE MALIGNANT BILIARY OBSTRUCTION
Authors: HW Lee, JH Moon, HJ Choi, YN Lee, TH Lee, MH Choi, SW Cha, YD Cho, SH Park
Journal: Endoscopy (2018)

Preoperative biliary drainage (PBD) can be performed to relieve jaundice or cholangitis in patients with malignant biliary obstruction (MBO). Fully covered self-expandable metal stent (FCSEMS) may be better than plastic stent (PS) for PBD. However, modification of current FCSEMS designed originally for nonresectable MBO is needed to be an ideal stent for PBD. The aim of this study was to evaluate the possible superiority of modified FCSEMS (M-FCSEMS) over PS, by comparing the PBD-related outcomes, re-intervention rates, and postoperative adverse events in patients with resectable MBO.
Long‐Term Outcomes Following Achievement of Clinically Inactive Disease in Juvenile Idiopathic Arthritis
Authors: Stephanie J. W. Shoop‐Worrall, Suzanne M. M. Verstappen, Janet E. McDonagh, Eileen Baildam, Alice Chieng, Joyce Davidson, Helen Foster, Yiannis Ioannou, Flora McErlane, Lucy R. Wedderburn, W. Thomson, Kimme L. Hyrich
Journal: Arthritis & Rheumatology (2018)

Objective Potential targets for treat‐to‐target strategies in juvenile idiopathic arthritis are minimal disease activity ( MDA ) and clinically inactive disease ( CID ). We undertook this study to compare short‐ and long‐term outcomes following achievement of MDA and CID on the 10‐joint clinical Juvenile Arthritis Disease Activity Score ( cJADAS 10) and following achievement of CID on Wallace et al's preliminary criteria. Methods Children recruited to the Childhood Arthritis Prospective Study, a UK multicenter inception cohort, were selected if they were recruited prior to January 2011 and diagnosed as having oligoarthritis or rheumatoid factor–negative or –positive polyarthritis. One year following diagnosis, children were assessed for MDA on the cJADAS 10 and for CID on both Wallace et al's preliminary criteria and the cJADAS 10. Associations were tested between those disease states and functional ability, absence of joints with limited range of motion, psychosocial health, and pain at 1 year and annually to 5 years. Results Of 832 children, 70% were female and the majority had oligoarthritis (68%). At 1 year, 21% had achieved CID according to both definitions, 7% according to Wallace et al's preliminary criteria alone, and 16% according to the cJADAS 10 alone; 56% had not achieved CID . Only 10% of children in the entire cohort achieved MDA without also achieving CID . Achieving either early CID state was associated with a greater absence of joints with limited range of motion. However, only CID according to the cJADAS 10 was associated with improved functional ability and psychosocial health. Achieving CID was superior to achieving MDA in terms of short‐ and long‐term pain and the absence of joints with limited range of motion. Conclusion CID on the cJADAS 10 may be preferable as a treatment target to CID on Wallace et al's preliminary criteria in terms of both feasibility of application and long‐term outcomes.
TREATMENT OF REFRACTORY STRICTURES OF DIGESTIVE TRACT WITH AXIOS STENT
Authors: F Junquera, E Brullet, E Martínez-Bauer, V Puig-Diví, M Miquel, S Machlab, P García Iglesias, M Gallach, J Seixas, R Campo
Journal: Endoscopy (2018)

Axios stent was originally designed as a luminal apposition stent. It is widely usely for EUS- guided drainage of intrabdominal collections. However its endoluminal use may broaden new indications such as refractory strictures of digestive tract
Maintaining reciprocal health rights post-Brexit would benefit UK, says Lords report
Authors: Ingrid Torjesen
Journal: BMJ (2018)

It is not in the UK’s interests for reciprocal healthcare arrangements with the European Union and the European Economic Area to end after Brexit, a report from the House of Lords EU Committee has concluded.1

Although only around 1.2 million UK citizens live in other EU countries—compared with around three million EU citizens living in the UK—around 190 000 of those UK citizens are pensioners, compared with just 5800 EU/EEA citizens, the committee said.

The UK spends about £500m (€572m; $708m) a year reimbursing EU member states for healthcare provided to UK citizens. The report says that the Department of Health and Social Care has accepted that the system is cost effective for the UK, as treatment overseas is often cheaper. For example, the average cost of providing healthcare to a pensioner in Spain is €4173 (£3650), compared with …
A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever
Authors: Emily Speranza, Sandra L. Bixler, Louis A. Altamura, Catherine E. Arnold, William D. Pratt, Cheryl Taylor-Howell, Christina Burrows, William Aguilar, Franco Rossi, Joshua D. Shamblin, Suzanne E. Wollen, Justine M. Zelko, Timothy Minogue, Elyse Nagle, Gustavo Palacios, Arthur J. Goff, John H. Connor
Journal: Science Translational Medicine (2018)

An animal model of Ebola virus infection with variable disease onset identifies host markers of infection that precede symptoms by 4 days.
AORTOENTERIC AND ARTERIO-ENTERIC FISTULA BLEEDING – WHAT IS THE ROLE OF ENDOSCOPY?
Authors: I Budimir, D Kralj, V Tomasic, M Nikolic, N Ljubicic, M Zovak, Z Gavranovic, I Budimir Jr
Journal: Endoscopy (2018)

The aim of this study was to show epidemiological, clinical and endoscopic characteristics of patients bleeding from an aortoenteric (AOEF) or arterio-enteric fistula (AEF) including thirty-day rebleeding rate, mortality and the need for blood transfusion.
Clinical activity of nivolumab in patients with non-clear cell renal cell carcinoma
Authors: Vadim S. Koshkin, Pedro C. Barata, Tian Zhang, Daniel J. George, Michael B. Atkins, William J. Kelly, Nicholas J. Vogelzang, Sumanta K. Pal, JoAnn Hsu, Leonard J. Appleman, Moshe C. Ornstein, Timothy Gilligan, Petros Grivas, Jorge A. Garcia, Brian I. Rini
Journal: Journal for ImmunoTherapy of Cancer (2018)

<h3>Background</h3> Nivolumab is approved for patients with metastatic renal cell carcinoma (mRCC) refractory to prior antiangiogenic therapy. The clinical activity of nivolumab in patients with non-clear cell RCC subtypes remains unknown as these patients were excluded from the original nivolumab trials. <h3>Methods</h3> Patients from 6 centers in the United States who received at least one dose of nivolumab for non-clear cell mRCC between 12/2015 and 06/2017 were identified. A retrospective analysis including patient characteristics, objective response rate according to RECIST v1.1 and treatment-related adverse events (TRAEs) was undertaken. <h3>Results</h3> Forty-one patients were identified. Median age was 58&nbsp;years (33–82), 71% were male, and majority had ECOG PS 0 (40%) or 1 (47%). Histology included 16 papillary, 14 unclassified, 5 chromophobe, 4 collecting duct, 1 Xp11 translocation and 1 MTSCC (mucinous tubular and spindle cell carcinoma). Among 35 patients who were evaluable for best response, 7 (20%) had PR and 10 (29%) had SD. Responses were observed in unclassified, papillary and collecting duct subtypes. In the entire cohort, median follow-up was 8.5&nbsp;months and median treatment duration was 3.0&nbsp;months. Median PFS was 3.5&nbsp;months and median OS was not reached. Among responders, median time to best response was 5.1&nbsp;months, and median duration of response was not reached as only 2 out of 7 responders had disease progression during follow-up. TRAEs of any grade were noted in 37% and most commonly included fatigue (12%), fever (10%) and rash (10%). Nivolumab treatments were postponed in 34% and discontinued in 15% of patients due to intolerance. No treatment-related deaths were observed. <h3>Conclusions</h3> Nivolumab monotherapy demonstrated objective responses and was well tolerated in a heterogeneous population of patients with non-clear cell mRCC. In the absence of other data in this treatment setting, this study lends support to the use of nivolumab for patients with metastatic non-clear cell renal cell carcinoma.
CORRELATION BETWEEN COLONOSCOPY WITHDRAWAL TIME AND ADENOMA DETECTION RATE AND THEIR IMPACT ON QUALITY OF COLONOSCOPY
Authors: N Nekhaykova, S Kashin, T Kryukova, A Belova, E Krainova
Journal: Endoscopy (2018)

Both adenoma detection rate (ADR) and colonoscopy withdrawal time (CWT) are recognized as measures of colonoscopy quality. An increased CWT has been associated with increased ADR. The aim of our study was to examine the relationship between CWT and ADR.
Relationship Status After Bariatric Surgery
Authors: Joseph R. Imbus, Luke M. Funk
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
The relevance of tyrosine kinase inhibitors for global metabolic pathways in cancer
Authors: Michaela Poliaková, Daniel M. Aebersold, Yitzhak Zimmer, Michaela Medová
Journal: Molecular Cancer (2018)

Tumor metabolism is a thrilling discipline that focuses on mechanisms used by cancer cells to earn crucial building blocks and energy to preserve growth and overcome resistance to various treatment modalities. At the same time, therapies directed specifically against aberrant signalling pathways driven by protein tyrosine kinases (TKs) involved in proliferation, metastasis and growth count for several years to promising anti-cancer approaches. In this respect, small molecule inhibitors are the most widely used clinically relevant means for targeted therapy, with a rising number of approvals for TKs inhibitors. In this review, we discuss recent observations related to TKs-associated metabolism and to metabolic feedback that is initialized as cellular response to particular TK-targeted therapies. These observations provide collective evidence that therapeutic responses are primarily linked to such pathways as regulation of lipid and amino acid metabolism, TCA cycle and glycolysis, advocating therefore the development of further effective targeted therapies against a broader spectrum of TKs to treat patients whose tumors display deregulated signalling driven by these proteins.
Targeted Intraoperative Radiation Therapy—A Promising Option for Accelerated Partial Breast Irradiation
Authors: Amishi Bajaj, Dennis R. Holmes, William Small
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
STAT3 Gain of Function: A New Kid on the Block in Interstitial Lung Diseases
Authors: Alexandre Fabre, Sarah Marchal, Lisa Renee Forbes, Tiphanie Phillips Vogel, Vincent Barlogis, Valérie Triolo, Pierre-Simon Rohrlich, Etienne Bérard, Diane Frankel, Damien Ambrosetti, Christine Soler, Marie Hoflack, Marie Baque, Emmanuelle Bosdure, Mélisande Baravalle, Ania Carsin, Jean-Christophe Dubus, Lisa Giovannini-Chami
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
24/7 ENDOSCOPY: IS IT NECESSARY?
Authors: A Denisova, A Samoylenko, P Zhegalov, N Antipenko, V Melkomukov, R Chaschin
Journal: Endoscopy (2018)

Nonvariceal Upper GI bleeding (UGIB) is frequent condition in a daily clinical practice. One of the leading positions in hemostasis belongs to endoscopic procedures with wide spectrums of hemostatic facilities available. Aim was to analyze hospital's experience to understand if emergency endoscopy is needed in clinic that doesn't accept acute patients with GI bleeding, but have 1168 beds in 56 departments including 5 intensive care units (ICU).
INCIDENCE OF REMNANT CBD STONES IN PATIENTS UNDERWENT CHOLECYSTECTOMY AFTER ENDOSCOPIC CHOLEDOCHOLITHIASIS EXTRACTION FOR CHOLECYSTO-CHOLEDOCHOLITHIASIS
Authors: JW Choe, D Kim, SH Hwang, D Lee, SY Kim, SW Jung, JS Koo, SW Lee
Journal: Endoscopy (2018)

Patients with cholecysto-choledocholithiasis undergo generally cholecystectomy after endoscopic choledocholithiasis extraction. Early recurrence of common bile duct (CBD) stone after cholecystectomy can occur due to migration of cholecystolithiasis into bile duct during operation or incomplete endoscopic removal of choledocholithiasis. The aim of this study was to investigate the incidence of remnant CBD stones after cholecystectomy.
FACTORS RELATED TO INADEQUATE COLON CLEANSING
Authors: C Mangas, E Santana, J Cubiella, A Suárez, I Portillo, A Seoane, M Ponce, P Díez, E Quintero, M Herráiz, M Pellisé, Á Ferrández, V Hernández, Á Pizarro, R Jover
Journal: Endoscopy (2018)

Adequate colon cleansing is mandatory to fulfil colonoscopy quality indicators, so the aim was to evaluate which factors were related to an inadequate colon cleasing.
Abstract 13989: Duration of Interventricular Septal Shift Predicts Clinical Outcome in Patients With Precapillary Pulmonary Hypertension: A CMR Study
Authors: George Giannakoulas, Sophia-Anastasia Mouratoglou, Alexandros Kallifatidis, Stavros Hadjimiltiades, Georgia Pitsiou, Ioannis Stanopoulos, Haralambos Karvounis
Journal: Circulation (2015)

Introduction: Right ventricular pressure overload results in interventricular septal (IVS) shift towards the left ventricle in patients with precapillary pulmonary hypertension (pPH). Hypothesis: The duration of IVS shift towards left ventricle during the cardiac cycle, as expressed by a novel marker called curvature duration index (CDi), predicts clinical outcome in pPH patients. Methods: This was a prospective study. All patients underwent cardiac magnetic resonance (CMR, Avanto Siemens 1,5T). CMR parameters of right ventricular function and dimensions were assessed. CDi (duration of IVS shift towards left ventricle x 100/cardiac cycle duration) was defined in the short-axis view at the level of papillary muscles (Figure 1). Time from enrollment to clinical failure (hospitalization due to pPH, initiation of parenteral prostanoid therapy, atrial septostomy or death) was recorded. Results: Our study included 36 consecutive patients (28 women, mean age 50.6±13.8 years) with pPH. Over a median follow-up period of 20.4 months (IQR 16.3-24.6 months) 14 clinical events were observed. In Cox proportional hazard analysis, only baseline CDi was significantly related to the composite event (HR 1.05, 95% CI 1.01-1.08, p=0.016). ROC curve analysis showed that the optimal cut-off value of CDi which predicted events was 66.7%. Kaplan-Meier survival analysis showed that CDi ≥66.7% was associated with a 9-fold increased risk for clinical failure (Figure 2). Conclusions: Ventricular septal shift towards left ventricle lasting for more than the 2/3 of the cardiac cycle is associated with worse prognosis in pPH.
BLUE LIGHT IMAGING FOR BARRETT'S NEOPLASIA CLASSIFICATION (BLINC): A NEW ENDOSCOPIC CLASSIFICATION IN BARRETT'S OESOPHAGUS
Authors: S Subramaniam, K Kandiah, F Chedgy, A Alkandari, R Bhattacharyya, G Longcroft-Wheaton, P Basford, P Aepli, A Pischel, M Stefanovic, E Schoon, P Bhandari
Journal: Endoscopy (2018)

Neoplasia in Barrett's can be subtle and difficult to identify. Blue light imaging (BLI) is a novel advanced endoscopic technology that provides high intensity contrast imaging for superior visualisation of mucosal surface and vessel patterns. This can improve the identification of Barrett's neoplasia. To date there is no formal classification system that enables the characterisation of neoplastic and non-neoplastic Barrett's for BLI. The aim of our study was to develop and validate a classification to identify Barrett's neoplasia using BLI.
The evaluation of Rosemont classification for EUS diagnosis of chronic pancreatitis; Comparative study between the Rosemont classification and the traditional criteria
Authors: Ikeda Tsunehiko
Journal: Endoscopy (2011)

Background: The clinical course of chronic pancreatitis (CP) leads to a high rate of morbidity and mortality over a 20- to 25-year period. Therefore, it's important to diagnose it at its early stage and for optimal management. Endoscopic ultrasound (EUS) provides excellent detail of parenchyma and duct which are not detectable by other imaging modalities, because of its ability to place the transducer in close proximity to the pancreas. Although EUS criteria for CP has been proposed by some investigators (conventional criteria based on the number of EUS findings), recently, Rosemont consensus meeting proposed the new EUS diagnostic criteria in consideration of value of each EUS finding to make a consensus of EUS diagnosis of CP (Rosemont classification). The aim of this study is to evaluate and verify the significance of the Rosemont classification by comparative study between traditional criteria and new criteria.
Natural orifice transluminal endoscopic surgery
Authors: S. Garud, F. Willingham
Journal: Endoscopy (2012)

The first natural orifice transluminal endoscopic surgery (NOTES) in a swine model was reported at Digestive Disease Week (DDW) in 2000 [1], and it has now been one decade since the first human case video demonstration [2]. Ten years later, the field is evolving and maturing. A range of procedures such as single-port surgery, hybrid surgery, endoscopic submucosal dissection (ESD), and per-oral endoscopic myotomy (POEM) are now often grouped under the NOTES umbrella though they may not use a natural orifice, and they may not be transluminal. POEM is considered by some to be the first sentinel application in NOTES [3]. Hybrid and submucosal approaches to upper gastrointestinal tumors in humans may spare major organ resection with life-long quality-of-life implications [4] [5] [6]. At DDW 2012 (19 – 22 May, San Diego, California, USA) data were presented on pure NOTES procedures performed using only conscious sedation [7], and percutaneous flexible endoscopy-based extraction of gallstones was demonstrated [8]. Although growth in the field is escaping strict definitions, the concept of NOTES continues to embolden progress on a host of clinical problems. At DDW 2012, there were 22 NOTES abstracts and 4 POEM abstracts, representing a steady level of research, following 26 abstracts in 2010 and 25 in 2011. The top 20 abstracts of 2012 are reviewed below.