tbuckley/cabot-search huggingface dataset:
Ongoing mumps outbreak in Israel, January to August 2017
Authors: Viki Indenbaum, Judith M Hübschen, Chen Stein-Zamir, Ella Mendelson, Danit Sofer, Musa Hindiyeh, Emilia Anis, Nitza Abramson, Eric J Haas, Yochi Yosef, Larisa Dukhan, Shepherd Roee Singer
Journal: Eurosurveillance (2017)

In Israel, 262 mumps cases were registered between 1 January and 28 August 2017 despite a vaccine coverage of ≥ 96%. The majority (56.5%) of cases were adolescents and young adults between 10 and 24 years of age. Nearly twice as many cases were reported in males than in females. Sequence information identified genotype G and suggested specific transmission chains in different religious communities, with the Muslim population in Jerusalem being most severely affected.
2017 Focused Update of the 2016 ACC Expert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk
Authors: Donald M. Lloyd-Jones, Pamela B. Morris, Christie M. Ballantyne, Kim K. Birtcher, David D. Daly, Sondra M. DePalma, Margo B. Minissian, Carl E. Orringer, Sidney C. Smith
Journal: Journal of the American College of Cardiology (2017)
Optomechanical devices for deep plasma cancer proteomics
Authors: Priscila M. Kosaka, Montserrat Calleja, Javier Tamayo
Journal: Seminars in Cancer Biology (2017)

Most of the cancer deaths could be avoided by early detection of the tumor when it is confined to its primary site and it has not metastasized. To this aim, one of the most promising strategies is the discovery and detection of protein biomarkers shed by the young tumor to the bloodstream. Proteomic technologies, mainly mass spectrometry and multiplexed immunoassays, have rapidly developed during last years with improved limits of detection and multiplexing capability. Unfortunately, these developments together major investments and large international efforts have not resulted into new useful protein biomarkers. Here, we analyze the potential and limitations of current proteomic technologies for detecting protein biomarkers released into circulation by the tumor. We find that these technologies can hardly probe the deepest region of the plasma proteome, at concentrations below the pg/mL level, where protein biomarkers for early cancer detection may exist. This clearly indicates the need of incorporating novel ultrasensitive techniques to the proteomic tool-box that can cover the inaccessible regions of the plasma proteome. We here propose biological detectors based on nanomechanical systems for discovery and detection of cancer protein biomarkers in plasma. We review the modes of operation of these devices, putting our focus on recent developments on nanomechanical sandwich immunoassays and nanomechanical spectrometry. The first technique enables reproducible immunodetection of proteins at concentrations well below the pg/mL level, with a limit of detection on the verge of 10 ag/mL. This technology can potentially detect low abundance tumor-associated proteins in plasma at the very early stages of the tumor. The second technique enables the identification of individual intact proteins by two physical coordinates, the mass and stiffness, instead of the mass-to-charge ratio of the protein constituents. This technology enormously simplifies the identification of proteins and it can provide useful information on interactions and posttranslational modifications, that otherwise is lost in mass spectrometry.
Clinical screening of oropharyngeal dysphagia: standard of care
Authors: Eric Verin
Journal: European Respiratory Journal (2017)

We were very interested in the comments made by I. Cavedies and co-workers regarding our paper entitled "Oropharyngeal dysphagia: when swallowing disorders meet respiratory diseases" [1]. Oropharyngeal dysphagia in respiratory disease: a submarine <http://ow.ly/s8JT30dKJwc>
FRI0620 MIR-204-3P inhibits the production of TLR4-related cytokines in familial mediterranean fever by targeting the PIK3 signaling pathway
Authors: T Koga, K Migita, M Umeda, F Nonaka, S-Y Kawashiri, N Iwamoto, K Ichinose, M Tamai, H Nakamura, T Origuchi, K Eguchi, A Kawakami
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> MicroRNAs (miRNAs) are endogenous small RNAs and post-transcriptionally regulate gene expression by pairing with target. There has been emerging evidence showing the association of aberrantly expressed circulating miRNAs in the serum with the pathogenesis or progression of diseases including cancer and autoimmune disease. Although a number of circulating miRNAs associated with inflammation have been identified, the roles of them in patients with FMF and the underlying mechanism remain to be elucidated. <h3>Objectives</h3> The aim of this study was to identify a serum miRNAs profile and potential biomarkers in FMF and clarify their gene targets for understanding the pathogenesis of autoinflammatory diseases. <h3>Methods</h3> We performed miRNA microarray in the serum from FMF in attack and in remission. We subsequently examined the expression of miRNAs that varied before and after the attack in macrophages derived from THP-1 cells stimulated with toll-like receptor (TLR) ligands. Macrophages derived from THP-1 cells transfected with pre-miRNA and anti-miRNA were stimulated with TLR ligands for 24 hours. We collected the supernatants for the quantification of inflammatory cytokine production. To identify the target genes, we overexpressed its miRNA and performed Agilent expression microarray. Transfection with reporter construct and pre-miRNA and anti-miRNA was performed to confirm suppression of target mRNA. <h3>Results</h3> We found that miR-204–3p was greatly decreased in the serum from FMF patients in attack. In vitro study, the expression of miR-204–3p was suppressed by LPS stimulation in macrophages derived from THP-1 cells. Inhibition of miR-204–3p significantly induced the production of TLR4-related cytokines whereas overexpression of miR-204–3p inhibited their production. Bioinformatic analysis showed that miR-204–3p is predicted to target genes implicated in TLR pathway through regulation of PIK3 signaling. Reporter assay revealed that miR-204–3p directly suppressed the luciferase activity of 39UTR of PIK3CG reporter construct. <h3>Conclusions</h3> These data suggest that serum miR-204–3p has a potential as a useful biomarker among patients with FMF and that miR-204–3p plays a critical role as a suppressor to regulate the production of TLR4 related cytokines by targeting PIK3 signaling pathway. <h3>Disclosure of Interest</h3> None declared
Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression
Authors: Heather J. Dalton, Sunila Pradeep, Michael McGuire, Yared Hailemichael, Shaolin MA, Yasmin Lyons, Guillermo N. Armaiz-Pena, Rebecca A. Previs, Jean Marie Hansen, Rajesha Rupaimoole, Vianey Gonzalez-Villasana, Min Soon Cho, Sherry Y. Wu, Lingegowda S. Mangala, Nicholas B. Jennings, Wei Hu, Robert Langley, Hong Mu, Michael Andreeff, Menashe Bar-Eli, Willem Overwijk, Prahlad Ram, Gabriel Lopez-Berestein, Robert L. Coleman, Anil K. Sood
Journal: Clinical Cancer Research (2017)

Abstract Purpose: VEGF-targeted therapies have modest efficacy in cancer patients, but acquired resistance is common. The mechanisms underlying such resistance are poorly understood. Experimental Design: To evaluate the potential role of immune cells in the development of resistance to VEGF blockade, we first established a preclinical model of adaptive resistance to anti-VEGF therapy. Additional in vitro and in vivo studies were carried out to characterize the role of macrophages in such resistance. Results: Using murine cancer models of adaptive resistance to anti-VEGF antibody (AVA), we found a previously unrecognized role of macrophages in such resistance. Macrophages were actively recruited to the tumor microenvironment and were responsible for the emergence of AVA resistance. Depletion of macrophages following emergence of resistance halted tumor growth and prolonged survival of tumor-bearing mice. In a macrophage-deficient mouse model, resistance to AVA failed to develop, but could be induced by injection of macrophages. Downregulation of macrophage VEGFR-1 and VEGFR-3 expression accompanied upregulation of alternative angiogenic pathways, facilitating escape from anti-VEGF therapy. Conclusions: These findings provide a new understanding of the mechanisms underlying the modest efficacy of current antiangiogenesis therapies and identify new opportunities for combination approaches for ovarian and other cancers. Clin Cancer Res; 23(22); 7034–46. ©2017 AACR.
Extracellular vesicles as potential biomarkers of acute graft-vs-host disease
Authors: G Lia, L Brunello, S Bruno, A Carpanetto, P Omedè, M Festuccia, L Tosti, E Maffini, L Giaccone, M Arpinati, G Ciccone, M Boccadoro, A Evangelista, G Camussi, B Bruno
Journal: Leukemia (2017)
Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials
Authors: Brandon M. Nathan, David Boulware, Susan Geyer, Mark A. Atkinson, Peter Colman, Robin Goland, William Russell, John M. Wentworth, Darrell M. Wilson, Carmella Evans-Molina, Diane Wherrett, Jay S. Skyler, Antoinette Moran, Jay M. Sosenko
Journal: Diabetes Care (2017)

We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose, and 60-min C-peptide levels) as prediagnostic end points for type 1 diabetes among Type 1 Diabetes TrialNet Pathway to Prevention Study participants.Two cohorts were analyzed: 1) baseline normoglycemic oral glucose tolerance tests (OGTTs) with an incident dysglycemic OGTT and 2) baseline Index60 <1.00 OGTTs with an incident Index60 ≥1.00 OGTT. Incident dysglycemic OGTTs were divided into those with (DYS/IND+) and without (DYS/IND-) concomitant Index60 ≥1.00. Incident Index60 ≥1.00 OGTTs were divided into those with (IND/DYS+) and without (IND/DYS-) concomitant dysglycemia.The cumulative incidence for type 1 diabetes was greater after IND/DYS- than after DYS/IND- (P < 0.01). Within the normoglycemic cohort, the cumulative incidence of type 1 diabetes was higher after DYS/IND+ than after DYS/IND- (P < 0.001), whereas within the Index60 <1.00 cohort, the cumulative incidence after IND/DYS+ and after IND/DYS- did not differ significantly. Among nonprogressors, type 1 diabetes risk at the last OGTT was greater for IND/DYS- than for DYS/IND- (P < 0.001). Hazard ratios (HRs) of DYS/IND- with age and 30- to 0-min C-peptide were positive (P < 0.001 for both), whereas HRs of type 1 diabetes with these variables were inverse (P < 0.001 for both). In contrast, HRs of IND/DYS- and type 1 diabetes with age and 30- to 0-min C-peptide were consistent (all inverse [P < 0.01 for all]).The findings suggest that incident dysglycemia without Index60 ≥1.00 is a suboptimal prediagnostic end point for type 1 diabetes. Measures that include both glucose and C-peptide levels, such as Index60 ≥1.00, appear better suited as prediagnostic end points.
Sudden Cardiac Death in Professional Soccer Players
Authors: Alejandro Santos-Lozano, Juan Martín-Hernández, Carlos Baladrón, María Ángeles Turrado-Sevilla, Ángel Arrarás-Flores, Julián P. Villacastín, Araceli Boraita, Héctor Bueno, Alejandro Lucia
Journal: Journal of the American College of Cardiology (2017)
Three-dimensional analysis of the physiological foramen geometry of maxillary and mandibular molars by means of micro-CT
Authors: Thomas Gerhard Wolf, Frank Paqué, Michael Sven Patyna, Brita Willershausen, Benjamín Briseño-Marroquín
Journal: International Journal of Oral Science (2017)

The aim of this study was to investigate the physiological foramen diameter, shape and distance between physiological and anatomical apex of maxillary and mandibular first and second molars. Accurate knowledge of the physiological foramina morphology; thus, inherent mechanical shaping technical hindrances, is decisive when taking the corresponding root canal final preparation decision. The morphological dimensions of a total of 1727 physiological foramina were investigated by means of micro-computed tomography. Mean narrow and wide (to a high number, oval) diameters of the physiological foramen were 0.24, 0.22 and 0.33 mm and 0.33, 0.31 and 0.42 mm in mesiobuccal (MB), distobuccal (DB) and palatal (P) roots in maxillary first molars; 0.24, 0.22 and 0.33 mm and 0.41, 0.33 and 0.44 in MB, DB, and P roots in maxillary second molars. Mandibular first molars showed mean narrow and wide diameters of 0.24 and 0.30 mm and of 0.39 and 0.46 mm in mesial (M) and distal (D) roots; second mandibular molars showed 0.25 and 0.31 mm and 0.47 mm in M and D roots. The mean distance between the physiological foramina and anatomical apex was 0.82, 0.81 and 1.02 mm and 0.54, 0.43 and 0.63 mm in MB, DB and P roots of the maxillary first and second molars, respectively. A mean distance of 0.95 mm (M) and 1.05 mm (D) in the first and 0.78 mm (M) and 0.81 mm (D) in the second mandibular molars was observed. Based on the results obtained, assumable recommendations for final preparation size of the physiological foramen were calculated. However, when taking into consideration, the resulting standard deviations of marginal errors must be cautiously considered when taking a final decision in clinical endodontic treatment. German and Swiss scientists have used computerized scanning techniques to map the root tips of molars to better inform dental practitioners. This research is highly applicable to clinical practice, as proper treatment of the root tips is a determining factor of root canal surgery success. Thomas Wolf of Germany's Johannes Gutenberg University of Mainz led a team to analyze 516 first and second human molars, scanning both upper (maxillary) and lower (mandibular) teeth to elucidate the anatomy of the root apex, the junction between the tooth and its surrounding tissue. This work allows scientists to provide recommendations on how dentists can best shape root canals during therapy. As well as a better understanding of tooth anatomy, this study presents the first fine-detail measurements of the root apex geometry of the first and second mandibular and maxillary molar.
Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas
Authors: Elodie Bal, Hyun-Sook Park, Zakia Belaid-Choucair, Hülya Kayserili, Magali Naville, Marine Madrange, Elena Chiticariu, Smail Hadj-Rabia, Nicolas Cagnard, Francois Kuonen, Daniel Bachmann, Marcel Huber, Cindy Le Gall, Francine Côté, Sylvain Hanein, Rasim Özgür Rosti, Ayca Dilruba Aslanger, Quinten Waisfisz, Christine Bodemer, Olivier Hermine, Fanny Morice-Picard, Bruno Labeille, Frédéric Caux, Juliette Mazereeuw-Hautier, Nicole Philip, Nicolas Levy, Alain Taieb, Marie-Françoise Avril, Denis J Headon, Gabor Gyapay, Thierry Magnaldo, Sylvie Fraitag, Hugues Roest Crollius, Pierre Vabres, Daniel Hohl, Arnold Munnich, Asma Smahi
Journal: Nature Medicine (2017)
ヒトCD8+肺常在性記憶T細胞の持続,警戒および制御のためのプログラム
Authors: Hombrink Pleun, Helbig Christina, Backer Ronald A, Piet Berger, Oja Anna E, Stark Regina, Brasser Giso, Jongejan Aldo, Jonkers Rene E, Nota Benjamin, Basak Onur, Clevers Hans C, Moerland Perry D, Amsen Derk, Van Lier Rene A W
Journal: Nature Immunology (2016)
High-Efficiency Transduction of Primary Human Hematopoietic Stem/Progenitor Cells By AAV6 Vectors: strategies for Overcoming Donor-Variation and Implications in Genome Editing
Authors: Chen Ling, Kanit Bhukhai, Zifei Yin, Mengqun Tan, Mervin Yoder, Philippe Leboulch, Emmanuel Payen, Arun Srivastava
Journal: Blood (2016)
THU0598 Can you hear the joints crying? musculoskeletal examination in junior doctors' medical admission clerkings
Authors: FYH Kwok, LH Lee, A Gupta
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Physical examination is an indispensable skill in the art of medicine which, together with history taking, enables physicians to achieve a clinical diagnosis. Previous studies have consistently shown wide variations in the documentation of physical examination findings on systemic review (1,2). In particular, musculoskeletal examination was found to be frequently omitted. <h3>Objectives</h3> The aim of this study was to evaluate the quality of junior doctors9 medical admission clerking, with a focus on clinical examination. <h3>Methods</h3> Fifty acute medical admission clerking entries by junior doctors in a university hospital were reviewed. Case notes were assessed for clinical details and physical examination performed. <h3>Results</h3> Mean age was 69. The commonest presenting complaint was fall or collapse. Musculoskeletal examination was only documented in 24% of admitted patients. There was disparity in the quality of documentation, ranging from complete omission to comments such as "valgus deformity", "erythema", "limited abduction" and "unable to SLR". Overall, the documentation of cranial nerves examination, limb neurological examination, abbreviated mental test and Glasgow coma scale was less robust (40%, 52%, 48% and 66% respectively). The documentation of musculoskeletal and neurological examination contrasts markedly with other systems: respiratory system 100%, cardiovascular system 98% and abdominal system 98%. <h3>Conclusions</h3> The omission of musculoskeletal examination may reflect a general apathy towards musculoskeletal health. Despite fall or collapse being the most common reason for medical admission in this study, musculoskeletal examination was only documented in a minority of patients. With an aging patient population, it is vital for physicians to address musculoskeletal disorders which are likely to be more prevalent on the acute medical take. Junior doctors9 lack of confidence in performing musculoskeletal examination may also be another contributing factor. It is important that junior doctors are provided feedback on their clinical assessment by senior doctors when essential components of examination are omitted. National training programmes should consider including these areas in postgraduate curriculum to ensure competency is achieved. <h3>References</h3> ) Doherty M, Abawi J, Pattrick M. Audit of medical inpatient examination: a cry from the joint. J R Coll Physicians Lond 1990;24(2):115–8. ) Myers A, McDonagh JE, Gupta K, et al. More "cries from the joints": assessment of the musculoskeletal system is poorly documented in routine paediatric clerking. Rheumatology (Oxford) 2004;43(8):1045–9. <h3>Disclosure of Interest</h3> None declared
Shockwave treatment for medial tibial stress syndrome in military cadets: A single-blind randomized controlled trial
Authors: Santiago Gomez Garcia, Silvia Ramon Rona, Martha Claudia Gomez Tinoco, Mikhail Benet Rodriguez, Diego Mauricio Chaustre Ruiz, Francia Piedad Cardenas Letrado, África Lopez-Illescas Ruiz, Juan Maria Alarcon Garcia
Journal: International Journal of Surgery (2017)
Abstract 18648: Derangements in Hepatic Structure and Renal Function are Associated With Longer Duration of Follow-up After Fontan Completion
Authors: Thomas G Wilson, Yves d’Udekem, David S Winlaw, Rachael L Cordina, David S Celermajer, Gavin R Wheaton, Andrew Bullock, Thomas L Gentles, Robert G Weintraub, Robert N Justo, Leeanne E Grigg, Dorothy J Radford, Winita Hardikar, Michael Cheung, Timothy M Cain, Padma Rao, Stephen I Alexander, Diana Zannino, Ajay J Iyengar
Journal: Circulation (2016)

Introduction: In Fontan survivors, systemic venous hypertension may lead to liver and renal dysfunction. The incidence of hepatic & renal impairment, the best method of diagnosis, and their predisp...
PETおよび光イメージングのための相補的オリゴヌクレオチドプラットフォームを用いたハイブリダイゼーションに基づくアプタマー標識【Powered by NICT】
Authors: Park Jun Young, Lee Tae Sup, Song In Ho, Cho Ye Lim, Chae Ju Ri, Yun Mijin, Kang Hyungu, Lee Jung Hwan, Lim Jong Hoon, Cho Won Gil, Kang Won Jun
Journal: Biomaterials (2016)
Infectious Pneumorrhachis Due to Emphysematous Pyelonephritis
Authors: Carlos A. Gomez, Daniel Vela-Duarte, Peter J. Veldkamp
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Flail, flay, or fail: needle-knife versus transpancreatic sphincterotomy to access the difficult-to-cannulate bile duct during ERCP
Authors: Richard Kozarek
Journal: Endoscopy (2017)

See also: Transpancreatic sphincterotomy has a higher cannulation success rate than needle-knife precut papillotomy – a meta-analysisEndoscopy 2017; 49(09): 874-887DOI: 10.1055/s-0043-111717
In memoriam: Professor Philip H. Quanjer
Authors: Janet Stocks, Irene Steenbruggen
Journal: European Respiratory Journal (2017)

![Graphic][1]</img> A great sense of loss and sadness marked the recent death of Philip Quanjer, who passed away peacefully at his home in Nijverdal, the Netherlands on July 26, 2017 after a long and courageous battle against cancer, during which he defied all odds in order to complete the tasks he had set himself. Philip was a highly respected member of the global respiratory community, who devoted his life to understanding and describing lung health, remaining highly active in his field up to a few weeks before his death. Indeed, after “retiring” in 1997, he went on to publish a further 90 papers, an astonishing 55 of which being published during the last five years of his life. His efforts since the 1980s to improve the standard of lung function testing and develop more reliable reference values with which to interpret the results of such tests have won him international acclaim and immense respect and admiration from the global respiratory community. Such developments were essential in order to improve early detection of respiratory disease, irrespective of age, sex or ethnic background, and to clarify what factors impact negatively on lung development. Philip was born on September 12, 1936 in Pontianak (Netherlands East Indies, now Indonesia) and spent his formative years in a Japanese concentration camp (where he learnt to swim in crocodile infested rivers!) until liberation in 1945. His first two years of formal education, which did not commence until he was nine years of age, were spent in Thailand and Indonesia before his family returned to the Netherlands in 1948. Philip met the love of his life and future wife, Else Meijerink, while they were both high school students. They married in 1960, while he was still a student at Groningen University medical school (1955–1963), had four children (two sons … [1]: /embed/inline-graphic-1.gif
Skin Cancers Among Chronic Lymphocytic Leukemia (CLL) Patients - the Effect of UV Radiation and CLL Clinical Characteristics
Authors: Geffen Kleinstern, Abdul Rishi, Sara J Achenbach, Kari Rabe Chaffee, Neil E. Kay, Tait D. Shanafelt, Aaron Norman, Celine M. Vachon, Timothy G. Call, Christian L. Baum, James R Cerhan, Susan L. Slager
Journal: Blood (2016)
in vivoでのLPS誘導免疫増悪TLR4/MD2特異的ペプチド停止【Powered by NICT】
Authors: Park Seolhee, Shin Hyeon-Jun, Shah Masaud, Cho Hey-Young, Anwar Muhammad Ayaz, Achek Asma, Kwon Hyuk-Kwon, Lee Byugsung, Yoo Tae Hyeon, Choi Sangdun
Journal: Biomaterials (2017)