Discriminative Accuracy of [<sup>18</sup>F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders
Authors: Rik Ossenkoppele, Gil D. Rabinovici, Ruben Smith, Hanna Cho, Michael Schöll, Olof Strandberg, Sebastian Palmqvist, Niklas Mattsson, Shorena Janelidze, Alexander Santillo, Tomas Ohlsson, Jonas Jögi, Richard Tsai, Renaud La Joie, Joel Kramer, Adam L. Boxer, Maria L. Gorno-Tempini, Bruce L. Miller, Jae Y. Choi, Young H. Ryu, Chul H. Lyoo, Oskar Hansson
Journal: JAMA (2018)

<h3>Importance</h3> The positron emission tomography (PET) tracer [<sup>18</sup>F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. <h3>Objective</h3> To examine the discriminative accuracy of [<sup>18</sup>F]flortaucipir for AD vs non-AD neurodegenerative disorders. <h3>Design, Setting, and Participants</h3> In this cross-sectional study, 719 participants were recruited from 3 dementia centers in South Korea, Sweden, and the United States between June 2014 and November 2017 (160 cognitively normal controls, 126 patients with mild cognitive impairment [MCI], of whom 65.9% were amyloid-β [Aβ] positive [ie, MCI due to AD], 179 patients with AD dementia, and 254 patients with various non-AD neurodegenerative disorders). <h3>Exposures</h3> The index test was the [<sup>18</sup>F]flortaucipir PET standardized uptake value ratio (SUVR) in 5 predefined regions of interest (ROIs). Cut points for tau positivity were determined using the mean +2 SDs observed in controls and Youden Index for the contrast AD dementia vs controls. <h3>Main Outcomes and Measures</h3> The reference standard was the clinical diagnosis determined at the specialized memory centers. In the primary analysis, the discriminative accuracy (ie, sensitivity and specificity) of [<sup>18</sup>F]flortaucipir was examined for AD dementia vs all non-AD neurodegenerative disorders. In secondary analyses, the area under the curve (AUC) of [<sup>18</sup>F]flortaucipir SUVR was compared with 3 established magnetic resonance imaging measures (hippocampal volumes and AD signature and whole-brain cortical thickness), and sensitivity and specificity of [<sup>18</sup>F]flortaucipir in MCI due to AD vs non-AD neurodegenerative disorders were determined. <h3>Results</h3> Among 719 participants, the overall mean (SD) age was 68.8 (9.2) years and 48.4% were male. The proportions of patients who were amyloid-β positive were 26.3%, 65.9%, 100%, and 23.8% among cognitively normal controls, patients with MCI, patients with AD dementia, and patients with non-AD neurodegenerative disorders, respectively. [<sup>18</sup>F]flortaucipir uptake in the medial-basal and lateral temporal cortex showed 89.9% (95% CI, 84.6%-93.9%) sensitivity and 90.6% (95% CI, 86.3%-93.9%) specificity using the threshold based on controls (SUVR, 1.34), and 96.8% (95% CI, 92.0%-99.1%) sensitivity and 87.9% (95% CI, 81.9%-92.4%) specificity using the Youden Index–derived cutoff (SUVR, 1.27) for distinguishing AD dementia from all non-AD neurodegenerative disorders. The AUCs for all 5 [<sup>18</sup>F]flortaucipir ROIs were higher (AUC range, 0.92-0.95) compared with the 3 volumetric MRI measures (AUC range, 0.63-0.75; all ROIs<i>P</i> &lt; .001). Diagnostic performance of the 5 [<sup>18</sup>F]flortaucipir ROIs were lower in MCI due to AD (AUC range, 0.75-0.84). <h3>Conclusions and Relevance</h3> Among patients with established diagnoses at a memory disorder clinic, [<sup>18</sup>F]flortaucipir PET was able to discriminate AD from other neurodegenerative diseases. The accuracy and potential utility of this test in patient care require further research in clinically more representative populations.