tbuckley/cabot-search huggingface dataset:
TCT-485 Impact of Renal Function on Outcomes After Stent Implantation for Left Main Coronary Artery: A Report From the Multicenter Assessing Optical Percutaneous Coronary Intervention for Left Main Coronary Artery Stenting Registry
Authors: Akimune Kuwayama, Masanobu Ohya, Mamoru Toyofuku, Takeshi Morimoto, Hirooki Higami, Yasushi Fuku, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2017)
Abstract 13072: The 6 Minute Walk Test Improves Exercise Confidence in Chronic Heart Failure Patients
Authors: Francis J Ha, Samia R Toukhsati, Rosie Yates, James Cameron, David L Hare
Journal: Circulation (2016)

Introduction: Chronic heart failure (CHF) patients have poor adherence to self-care behaviours, particularly exercise. Patient confidence in their physical abilities is a known predictor of exercise adherence. However, factors influencing confidence are poorly understood and the efficacy of simple interventions to increase such confidence is not known. The aim of this single-site, repeated measures study was to evaluate the effects of a 6-minute walk test (6MWT) on exercise confidence in CHF patients. Methods: CHF patients attending an out-patient heart failure clinic at a major tertiary hospital were prospectively enrolled to perform a 6MWT under supervised conditions according to American Thoracic Society Guidelines. Consenting participants completed the Cardiac Depression Scale (CDS) at baseline and an Exercise Confidence Survey (range 0-100; higher scores indicate greater confidence) at baseline and following completion of a 6MWT. Baseline demographics, including CHF characteristics, were obtained from hospital medical records. Results: Fifty-seven CHF patients were eligible for enrolment to the study (81% males, mean age = 63 ± 13 years). Most patients (68%) had non-ischemic CHF aetiology and were NYHA class II or III. Over one quarter of patients (28%) were depressed (CDS ≥ 95). Baseline Total Exercise Confidence (mean 66 ± 24) was inversely associated with age (p&lt;0.01), NYHA class (p&lt;0.001), and depression (p&lt;0.001). Distance walked on 6MWT (mean = 400 ± 123 metres) was positively correlated with Baseline Total Exercise Confidence (p&lt;0.001) and with each of the baseline Exercise Confidence sub-scales (ie., Walking, Running, Climbing and Lifting Confidence; p&lt;0.001). Following the 6MWT, a significant improvement in Total Exercise Confidence (F ( 1, 49) = 7.26, p&lt;0.01) and Running Confidence (F (1, 51) = 4.77, p&lt;0.05) adjusted for age, CDS score and NYHA class, was observed. Conclusions: These findings suggest that the 6MWT is a simple and effective intervention to improve exercise confidence in chronic heart failure patients. These results may have important patient self-management implications; future research should monitor whether improvements in exercise confidence are persistent and translate to changes in exercise behaviours.
TCT-631 Optimal Timing of Percutaneous Coronary Intervention in Patients With Non-ST-Segment Elevation Myocardial Infarction Complicated by Acute Heart Failure
Authors: Dae Young Hyun, Min Chul Kim, Myung Ho Jeong, Doo Sun Sim, Young Joon Hong, None Juhan kim, Youngkeun Ahn, Tae Hoon Ahn, Seung Ki-Bae, Dong Joo Oh, Hyo-Soo Kim, Hyeon Cheol Gwon, In Whan Seong, Shung Chae, Young Jo Kim, Seok-Kyu Oh, Jei Keon Chae
Journal: Journal of the American College of Cardiology (2017)
Evaluation épidémiologique et virologique de l’activité grippale en Europe pendant la saison 2003-2004
Authors: W J Paget, T J Meerhoff, A Meijer
Journal: Eurosurveillance (2005)

En Europe, la saison grippale 2003-2004 a ete marquee par la dissemination d’un nouveau variant, le virus A/Fujian/411/2002 (H3N2) qui differe legerement du composant de la souche A(H3N2) utilise dans le vaccin anti-grippal. Des cas sporadiques ont ete detectes en Europe a la fin de la saison 2002-2003, et l’activite grippale associee a ce virus est survenue au debut de la saison 2003-2004. En general, l’activite grippale s’est d’abord manifestee en Europe occidentale (Irlande, Royaume-Uni et peninsule iberique) en octobre-novembre, puis elle s’est deplacee progressivement vers l’est a travers l’Europe, touchant la Lettonie, la Lituanie et la Pologne en janvier et fevrier 2004. Globalement, l’intensite de l’activite clinique a ete superieure a celle de la saison 2002-2003 (resultats de 13 reseaux sur 20). De plus, dans les pays qui declarent des donnees par tranches d’âge, les taux de consultations les plus elevees etaient observees chez les enfants de 0 a 14 ans. Neanmoins, malgre l’emergence de ce nouveau variant A(H3N2), les incidences cliniques n’ont pas connu de hausse particuliere comparees aux donnees historiques. La composition du vaccin anti-grippal 2004-2005 a ete modifiee comparee a celui de la saison 2003-2004 et comprend une souche analogue au virus A/Fujian/411/2002 (H3N2) et une nouvelle souche du type B (analogue a B/Shanghai/361/2002).
TCT-614 Simulated Neo-Left Ventricular Outflow Tract predicts Transvalvular Aortic Gradients Following Transatrial Balloon-Expandable Valve Replacement for the Treatment of Severe Mitral Annular Calcification
Authors: Fabien Praz, Raymond Lee, Hyde Russell, Mayra Guerrero, Ramesh Veeragandham, Ashequl Islam, David Deaton, Eudailey Kyle, Deniz Akkoc, Alex Kantor, Diane Tang, Joo-Eun Park, Diana Leung, Hiroo Takayama, Rebecca Hahn, Vinayak Bapat, Susheel Kodali, Michael Borger, Isaac Wu, Omar Khalique, Isaac George
Journal: Journal of the American College of Cardiology (2017)
Brote de intoxicación alimentaria por consumo de marisco en Amberes, Bélgica
Authors: K De Schrijver, I Maes, L De Man, J Michelet
Journal: Eurosurveillance (2002)

En Amberes, Belgica, se declararon 403 casos de intoxicacion alimentaria asociados a consumo de marisco tras la ingestion de mejillones azules. Los sintomas incluyeron diarrea, vomitos, dolor abdominal y nauseas. El analisis de muestras de heces de pacientes permitio excluir la presencia de bacterias y virus. Las pruebas en ratones revelaron la presencia de biotoxinas especificas de dinoflagelados, que fueron identificados y cuantificados por LC-MS. Los mejillones se habian importado de Dinamarca y formaban parte de un lote cuya concentracion de acido ocadaico era superior a la permitida por la ley.
Akt inhibitor radiosensitizes malignant glioma cells by enhancing autophagy
Authors: Keishi Fujiwara, Eiji Iwado, Seiji Kondo, Yasuko Kondo
Journal: Cancer Research (2006)

1377   Autophagy or programmed cell death type II is one of the responses of cancer cells against various therapies including ionizing radiation (Kondo  et al ., Nat Rev Cancer 5:726-734, 2005). Recently, we have shown that radiation induces autophagy, but not apoptosis, in different malignant glioma cell lines. Autophagy is a protein degradation system that is characterized by a prominent formation of autophagic vacuoles containing proteins and subcellular organelles. The mammalian target of rapamycin (mTOR) pathway mainly regulates autophagy. On the other hand, the Akt/mTOR pathway also mediates radioresistance. The purpose of our study was to examine an Akt inhibitor, 1L-6-hydroxy-methyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate, for its anticancer and radiosensitizing effects on malignant glioma U87-MG and U87-MGΔ epidermal growth factor receptor (EGFR) cells. U87-MGΔEGFR cells have a deletion of exons 2-7 of the  EGFR  gene, thus, having a constitutively active form of the receptor. Actually, we found that U87-MGΔEGFR cells were more radioresistant compared with the parental U87-MG cells. 20-40 μM of the Akt inhibitor successfully inhibited Akt activity and reduced cell viability in both cell lines. The Akt inhibitor decreased phosphorylated p70S6 kinase which is a downstream target of Akt, and induced autophagy, but not apoptosis. Specific inhibition of Akt using the dominant-negaive Akt plasmid also resulted in the induction of autophagy. Furthermore, 40 μM of the Akt inhibitor radiosensitized U87-MG and U87-MGΔEGFR cells. This radiosensitizing effect was due to enhancement of autophagy, but not induction of apoptosis. In conclusion, we showed for the first time that Akt inhibition radiosensitizes malignant glioma cells by enhancing autophagy. Akt inhibitors may represent a promising new therapy for radiosensitization of malignant gliomas including ones that express ΔEGFR.
Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
Authors: Yu Yuan, Yang Xiao, Wei Feng, Yiyi Liu, Yanqiu Yu, Lue Zhou, Gaokun Qiu, Hao Wang, Bing Liu, Kang Liu, Handong Yang, Xiulou Li, Xinwen Min, Ce Zhang, Chengwei Xu, Xiaomin Zhang, Meian He, Frank B. Hu, An Pan, Tangchun Wu
Journal: Environmental Health Perspectives (2017)

BACKGROUND: Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease.However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD).OBJECTIVES: We conducted a nested case-control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD.METHODS: A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age ( ± 5 years) and sex.We measured baseline fasting plasma concentrations of 23 metals and used conditional logistic regression models to estimate odds ratios (ORs) of CHD for metal concentrations categorized according to quartiles in controls.RESULTS: Five metals (titanium, arsenic, selenium, aluminum, and barium) were significantly associated with CHD based on trend tests from singlemetal multivariable models adjusted for established cardiovascular risk factors.When all five were included in the same model, adjusted ORs for barium and aluminum were close to the null, whereas associations with titanium, arsenic, and selenium were similar to estimates from single-metal models, and ORs comparing extreme quartiles were 1.32 (95% CI: 1.03, 1.69; p-trend = 0:04), 1.78 (95% CI: 1.29, 2.46; p-trend = 0:001), and 0.67 (95% CI: 0.52, 0.85; p-trend = 0:001), respectively.CONCLUSIONS: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium.Additional research is needed to confirm these findings in other populations.
Coalescent-Based Analyses of Genomic Sequence Data Provide a Robust Resolution of Phylogenetic Relationships among Major Groups of Gibbons
Authors: Cheng-Min Shi, Ziheng Yang
Journal: Molecular Biology and Evolution (2017)

The phylogenetic relationships among extant gibbon species remain unresolved despite numerous efforts using morphological, behavorial, and genetic data and the sequencing of whole genomes. A major challenge in reconstructing the gibbon phylogeny is the radiative speciation process, which resulted in extremely short internal branches in the species phylogeny and extensive incomplete lineage sorting with extensive gene-tree heterogeneity across the genome. Here, we analyze two genomic-scale data sets, with ∼10,000 putative noncoding and exonic loci, respectively, to estimate the species tree for the major groups of gibbons. We used the Bayesian full-likelihood method bpp under the multispecies coalescent model, which naturally accommodates incomplete lineage sorting and uncertainties in the gene trees. For comparison, we included three heuristic coalescent-based methods (mp-est, SVDQuartets, and astral) as well as concatenation. From both data sets, we infer the phylogeny for the four extant gibbon genera to be (Hylobates, (Nomascus, (Hoolock, Symphalangus))). We used simulation guided by the real data to evaluate the accuracy of the methods used. Astral, while not as efficient as bpp, performed well in estimation of the species tree even in presence of excessive incomplete lineage sorting. Concatenation, mp-est and SVDQuartets were unreliable when the species tree contains very short internal branches. Likelihood ratio test of gene flow suggests a small amount of migration from Hylobates moloch to H. pileatus, while cross-genera migration is absent or rare. Our results highlight the utility of coalescent-based methods in addressing challenging species tree problems characterized by short internal branches and rampant gene tree-species tree discordance.
Hospitalisations pour grippe et pneumonie d’origine communautaire dans le nord du Portugal, 2000-2005
Authors: J Dias, A M Correia, Laurinda Queirós
Journal: Eurosurveillance (2007)

Les admissions a l’hopital pour des cas de pneumonie, l’une des complications les plus frequentes de la grippe, sont plus courantes chez les enfants et les personnes âgees, ainsi que chez les personnes souffrant d’une maladie chronique.
TCT-827 Long-term Clinical Outcomes of Final Kissing Ballooning versus No Final Kissing Ballooning in Coronary Bifurcation Lesions Treated with 1-Stent Technique: A Systematic Review and Meta-Analysis of Observational and Randomized Studies
Authors: Yuan He, Dong Zhang, Kefei Dou
Journal: Journal of the American College of Cardiology (2017)
Association of severe pain with poor response to opioids, psychological distress, and aberrant drug taking behaviors in a large cohort of cancer patients.
Authors: Vinnidhy Dave, Ria Roberts, Yvona Griffo, Natalie Moryl, Roma Tickoo, Kenneth Cubert, Amitabh Gulati, Joseph Hung, Vinay Puttanniah, Susan Horn, Patrick Brown, Vivek Malhotra, Paul A. Glare, Charles Inturrisi
Journal: Journal of Clinical Oncology (2015)

9600 Background: Pain is one of the most feared consequences of cancer. Systematic reviews indicate opioids are effective for cancer pain, but are often under-utilized. At the same time, there is increased societal concern about opioid abuse. Identifying patients with a history of cancer who are at risk for poor pain outcomes is important when considering opioid therapy. The aim of this study was to evaluate associations between pain intensity, analgesic effectiveness, disability, distress and aberrant drug taking in the subpopulation from Memorial Sloan Kettering Cancer Center of a pain clinic registry. Methods: At each outpatient encounter, patients completed the Brief Pain Inventory, Condensed Memorial Symptom Assessment Scale (CMSAS) and Current Opioid Misuse Measure (COMM). Though not yet validated in patients with cancer, in other chronic pain populations a COMM score greater than 9 has a positive likelihood ratio for diagnosing opioid misuse/abuse of 3.5. Data analysis performed by International Severity Information Systems, Salt Lake City, UT. Results: From 6/18/2011 to 12/10/2014, 1593 of 2085 (76.4%) patients completing 5599 surveys reported continuing pain despite taking opioids. Average pain score was mild (1-4) in 25%, moderate (5-6) in 41%, severe (7-10) in 34%. Those with severe pain reported less relief from their pain medicine, were more disabled (higher pain interference), and had more physical and psychological distress and higher COMM scores (see Table, all p values < 0.001). Conclusions: Ambulatory patients with a cancer history who report severe pain despite taking opioids are a challenging management problem. These data suggest they have concomitant disability, physical and psychological distress, and behaviors suggestive of opioid misuse/abuse. To improve their outcomes, more research is needed to understand the causal links between these associations. Score Mild Moderate Severe Average pain intensity 3.2 5.5 7.8 Pain relief 62% 54% 45% Pain interference 4.0 5.6 7.0 Physical symptom distress score, CMSAS 1.5 1.7 1.9 Psychological distress score, CMSAS 1.3 1.6 2.0 COMM score 8.1 8.5 10.7
TCT-775 Prognostic value of calcium score before transcatheter aortic valve implantation performed with new generation prosthesis
Authors: Mariama Akodad, Benoit Lattuca, Audrey Agullo, Gregory Marin, Hélène Vernhet, Laurent Schmutz, Guillaume Cayla, Florence Leclercq
Journal: Journal of the American College of Cardiology (2017)
TCT-241 Outcomes with General Anesthesia Compared to Conscious Sedation in Patients Undergoing Transcatheter Aortic Valve Replacement
Authors: Rosemary Hansen, Tharmathai Ramanan, Abhishek Sawant, Priya Sadawarte, Aishwarya Bhardwaj, Everett Sinibaldi, Michael Pham, Charl Khalil, Kinjal Banerjee, Shannon Baldo, Gerald Colern, Vijay Iyer
Journal: Journal of the American College of Cardiology (2017)
Cost-effectiveness Analysis of Nivolumab for Treatment of Platinum-Resistant Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Authors: Kathryn R Tringale, Kate T Carroll, Kaveh Zakeri, Assuntina G Sacco, Linda Barnachea, James D Murphy
Journal: JNCI Journal of the National Cancer Institute (2017)

The CheckMate 141 trial found that nivolumab improved survival for patients with recurrent or metastatic head and neck cancer (HNC). Despite the improved survival, nivolumab is much more expensive than standard therapies. This study assesses the cost-effectiveness of nivolumab for the treatment of HNC. We constructed a Markov model to simulate treatment with nivolumab or standard single-agent therapy for patients with recurrent or metastatic platinum-refractory HNC. Transition probabilities, including disease progression, survival, and probability of toxicity, were derived from clinical trial data, while costs (in 2017 US dollars) and health utilities were estimated from the literature. Incremental cost-effectiveness ratios (ICERs), expressed as dollar per quality-adjusted life-year (QALY), were calculated, with values of less than $100 000/QALY considered cost-effective from a health care payer perspective. We conducted one-way and probabilistic sensitivity analyses to assess model uncertainty. Our base case model found that treatment with nivolumab increased overall cost by $117 800 and improved effectiveness by 0.400 QALYs compared with standard therapy, leading to an ICER of $294 400/QALY. The model was most sensitive to the cost of nivolumab, though nivolumab only became cost-effective if the cost per cycle decreased from $13 432 to $3931. The model was not particularly sensitive to assumptions about survival. If one assumed that all patients alive at the end of the CheckMate 141 trial were cured of their disease, nivolumab was still not cost-effective (ICER $244 600/QALY). While nivolumab improves overall survival, at its current cost it would not be considered a cost-effective treatment option for patients with HNC.
Image Gallery: Nail involvement in syphilis: the great forgotten
Authors: X. Fustà, D. Morgado-Carrasco, J.M. Mascaró
Journal: British Journal of Dermatology (2017)

Funding sources: no external funding. Conflicts of interest: none to declare. Dear Editor, A 36‐year‐old white male with untreated HIV infection presented with fever and a 2‐month history of erythematous scaly plaques affecting his palms and soles. All nail plates showed significant involvement, with Beau's lines, distal amber discoloration and onychomadesis. Treponemal and nontreponemal tests were positive, confirming a diagnosis of secondary syphilis. Normal nail regrowth was observed after penicillin treatment. Nail involvement in syphilis, despite being known for centuries, has been poorly described in recent literature. Its manifestations include opacity and amber discoloration of the nail plates, pitting, onycholysis, onychomadesis, elkonyxis, Beau's lines and paronychia.1,2
Abstract 13106: Over Expression of Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Explant Derived Cardiac Stem Cell Dysfunction
Authors: Melanie Villanueva, Darryl R Davis
Journal: Circulation (2016)

Diabetes increases the risk of heart disease and worsens clinical outcomes after myocardial infarction. Given that hyperglycemia promotes the generation of toxic methylglyoxal, the influence of the key detoxification enzyme glyoxalase 1 (Glo1) on chronic hyperglycemia induced explant-derived cardiac stem cell (EDC) dysfunction was investigated. Methods/Results: Sixteen-week old wild type (WT, n=22) or constitutive Glo1 overexpressing (Glo1TG, n=12) mice were studied 2 months after treatment with streptozotocin or vehicle (2.0±0.1 fold increase in glycated hemoglobin, p=0.001 vs vehicle treated mice). Hyperglycemia reduced overall culture yields (86±3% fewer EDCs cultured, p=0.0009) and prolonged population doubling time (30±4% slower growth, p=0.04) while increasing the cellular content of reactive dicarbonyls (27±3% more reactive oxygen species, p=0.0006) within EDCs cultured from WT mice. These intrinsic cell changes reduced the angiogenic potential (74±2% less total endothelial tubule formation, p=0.001) and production of pro-healing exosomes (43±6% fewer exosomes secreted, p=0.04) by hyperglycemic EDCs while promoting EDC senescence (98±28% more senescent EDCs, p=0.03). As compared to transplant of normoglycemic WT EDCs, hyperglycemia reduced the EDC-mediated increases in echocardiographic ejection fraction and dP/dTmax in infarcted normoglycemic WT mice 3 weeks after intra-myocardial injection by 37±8% (p=0.0001) and 25±1% (p=0.001), respectively. In contrast to EDCs cultured from WT hyperglycemic donors, EDCs cultured from Glo1TG mice: 1) decreased the reactive oxygen species content by 46±2% (p=0.0001), 2) increased cell culture yields by 2.2±0.2 fold (p=0.0004) and 3) boosted echocardiographic left ventricular ejection fraction by 27±7% (p=0.0001) while increasing dP/dTmax by 21±4% (p=0.007). Conclusions: Chronic hyperglycemia decreases the regenerative performance of EDCs. Over-expression of Glo1 reduces dicarbonyl stress and prevents chronic hyperglycemia-induced EDC dysfunction.
PRMT5 Targets Tumor Suppressor Micro RNAs to Regulate Cyclin D1 and c-MYC in Mantle Cell Lymphoma
Authors: Vrajesh Karkhanis, Lapo Alinari, Bethany Mundy, Michael Caliguri, Selina Chen-Kiang, Olivier Elemento, Sif Said, Robert A Baiocchi
Journal: Blood (2016)