tbuckley/cabot-search huggingface dataset:
Fresh and Processed Fruit and Vegetable Intake and Risk of Cardiovascular and All-Cause Mortality in a Dutch Population-Based Follow-up Study
Authors: L.M. Oude Griep, J.M. Geleijnse, D. Kromhout, W.M.M. Verschuren
Journal: Circulation (2009)

Introduction: Intake of fruit and vegetables has been shown to protect against CVD and all-cause mortality. Whether fresh and processed fruits have similar health effects remains unclear. Objective: We examined the association of total, fresh and processed fruit and vegetable intake with CVD and all-cause mortality in a population-based follow-up study in the Netherlands. Design and Methods: Between 1993-1997 a total of over 22,000 men and women aged 20-65 years were examined. Our analyses are based on 11,030 women and 9,118 men who were free of CVD at baseline. Fruit and vegetable intake was assessed by a validated 178 item food-frequency questionnaire. Seasonal differences were taken into account. Processed fruits are mainly fruit juices, whereas processed vegetables are cooked. Information on vital status and cause of death was obtained from national registries up to 2007. During follow-up, 678 participants died of whom 155 died of CVD. Hazard ratios (HRs) were calculated using the Cox proportional hazard model and adjustments were made for age, gender, energy intake, alcohol intake, smoking and socioeconomic status, supplement use, use of anti-hypertensive or cholesterol lowering drugs, family history of MI before 60 years, dietary fiber intake other than from fruit and vegetables, fish intake and saturated fatty acids. Results: A 100 gram increase of fruit intake was inversely associated with all-cause mortality, HR 0.94 (95%CI: 0.89-0.99). The HRs for fresh and processed fruit intake with all-cause mortality were 0.96 (0.93-0.99) and 0.98 (0.94-1.03), respectively. For a 50 gram increase of vegetable intake, we observed a reduction in all-cause mortality; 0.92 (0.85-0.99). The HRs for fresh and processed vegetable intake with all-cause mortality were 1.00 (0.97-1.04) and 0.89 (0.82-0.98), respectively. These trends in association were also observed for CVD mortality. However, these associations were less strong and borderline significant, which could be due to the low number of CVD deaths. Conclusion: Fruit and vegetable intake is inversely associated with all-cause mortality and possibly associated with CVD mortality in healthy, Dutch men and women. This relationship was mainly attributable to fresh fruit and processed vegetable intake.
Nivolumab ± ipilimumab treatment (Tx) efficacy, safety, and biomarkers in patients (Pts) with metastatic colorectal cancer (mCRC) with and without high microsatellite instability (MSI-H): results from the CheckMate-142 study
Authors: M.J. Overman, S. Kopetz, S. Lonardi, R. McDermott, F. Leone, J. Leach, H.-J. Lenz, A. Hendlisz, M. Morse, P. Garcia-Alfonso, J. Desai, A. Hill, R.A. Moss, M.V. Goldberg, C.-S. Lin, H. Tang, T. André
Journal: Annals of Oncology (2016)
Randomized phase II study of maintenance treatment with 5-FU/FA plus panitumumab vs 5-FU/FA alone after induction (mFOLFOX6 plus panitumumab) in patients with RAS WT metastatic colorectal cancer
Authors: D.P. Modest, S. Kasper, S. Stintzing, N. Prasnikar, L. Müller, K. Caca, E. Gökkurt, L. Fischer von Weikersthal, H.-G. Kopp, T. Trarbach
Journal: Annals of Oncology (2016)
Application of Data-Driven Approaches for Identifying Asthmatic Children with Suboptimal Asthma Care
Authors: Euijung Ryu, Chung-Il Wi, Sunghwan Sohn, Sungrim Moon, Hongfang Liu, Joy A. Green, Kathy D. Ihrke, Rhonda G. Unterborn, Philip H. Wheeler, Young J. Juhn
Journal: Journal of Allergy and Clinical Immunology (2017)
Blast Phase Chronic Myeloid Leukemia: A Pooled Analysis of Subcutaneous Omacetaxine Mepesuccinate in Treatment-Resistant Patients
Authors: H. Jean Khoury, Jorge E. Cortes, Meir Wetzler, Jeffrey H. Lipton, Michele Baccarani, Dan Douer, Adam Craig, Hagop M. Kantarjian, Luke Akard
Journal: Blood (2012)
Valproic Acid Induces Cell Cycle Arrest and Differentiation of t(15;17) Positive Leukemic Cells Independent from ATRA Sensitivity and Has No Effect on CD34pos Cells.
Authors: Bettina Drescher, Kerstin Goerlich, Dagmar Reile, Axel Doehring, Arnold Ganser, Gerhard Heil, Katharina Wagner, Juergen Krauter
Journal: Blood (2005)
Complications sévères de la myotomie par voie endoscopique: analyse systématique sur 5 années
Authors: G. Rahmi
Journal: Endoscopy (2016)

La myotomie par voie endoscopique (POEM) est un nouveau traitement de l’achalasie du sphincter inférieur de l’œsophage consistant à sectionner les fibres circulaires superficielles de la couche musculeuse (ou toute la couche comme 84 % des patients dans l’étude présentée) grâce à la réalisation d’un tunnel sous-muqueux. On comptait en 2015 plus de 3000 procédures réalisées dans le monde.
504PD High neutrophil-lymphocyte ratio is an independent indicator of poor prognosis in high grade undifferentiated pleomorphic sarcoma
Authors: W.H.W. Chew, J.Y. Chan, W.L. Goh, S. Sathiyamoorthy, K. Sittampalam, J. Teh, F. Chin, M.H. Tan, K.C. Soo, M. Teo, M. Farid, R. Quek
Journal: Annals of Oncology (2016)
A Growing Mass in the Nostril
Authors: Lorena Barboza-Guadagnini, Igor Shendrik, Carlos García
Journal: JAMA Dermatology (2017)

A man in his 30s presented with a 1-cm growing mass in the right nostril that was nontender, exophytic, and verrucous. The lesion bled with minimal trauma but did not obstruct his breathing. What is your diagnosis?
Impact of <scp>QRS</scp> complex duration and morphology on left ventricular reverse remodelling and left ventricular function improvement after cardiac resynchronization therapy
Authors: Pieter van der Bijl, Mand Khidir, Melissa Leung, Bart Mertens, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax
Journal: European Journal of Heart Failure (2017)
GP contract deal removes “bureaucratic workload” and brings 1% pay rise
Authors: Gareth Iacobucci
Journal: BMJ (2017)

General practices in England will get a 1% pay rise and no longer have a portion of their funding linked to numbers of unplanned hospital admissions from April after an agreement was reached between the BMA and the government.

The deal, announced on Tuesday 7 February, will end the unplanned admissions direct enhanced service (DES) and transfer the £156.7m (€182m; $196m) that funded this service directly into practices’ core funding.

The BMA said that the agreement, negotiated as part of a package of changes to the GP contract in England in 2017-18, would relieve practices of a “significant bureaucratic workload” and provide financial relief in key areas.

Under the terms of the deal, general practices will get a pay uplift of 1% alongside …
Regulation of Cadherin-related Family Member 3 Expression in Primary Human Bronchial Epithelial Cells and Respiratory Organ Cultures
Authors: Renee WY. Chan, Kin Pong Tao, Hai Chao Wang, Apple CM. Yeung, Yuping Song, Agnes SY. Leung, Gary WK. Wong, Paul KS. Chan, Ting Fan Leung
Journal: Journal of Allergy and Clinical Immunology (2017)
Total, Plant and Animal Protein Intake and Blood Pressure: A Meta-analysis of Observational and Intervention Studies
Authors: Susanne M. Tielemans, Wieke Altorf-van der Kuil, Marielle F. Engberink, Elizabeth J. Brink, Marleen A. van Baak, Stephan J. Bakker, Johanna M. Geleijnse
Journal: Circulation (2013)
433P High Beclin-1 expression predicts prolonged survival in locally advanced non-small cell lung cancer receiving docetaxel-platinum induction chemotherapy
Authors: H.Y. Lee, J.H. Shin, K.-Y. Lee, J.K. Park, S.W. Sung, Y.S. Kim, J.H. Kang, J.-O. Kim
Journal: Annals of Oncology (2016)
Successful implementation of a disease-specific survivorship program for men with prostate cancer (PC) and their partners.
Authors: Celestia S. Higano, Phil Pollock, Richard J Wassersug, Christine Zarowski, Marcy Dayan, Sarah Weller, Cheri Van Patten, Stacy Elliott, Monita Sundar, Sarah Mahovlich, Erik Wibowo, Martin Gleave, Peter C. Black, Alan So, Larry Goldenberg
Journal: Journal of Clinical Oncology (2016)

31 Background: Treatment for localized PC can adversely impact the quality of life for the patient (pts) and his partner. Addition of androgen deprivation therapy (ADT) to treat biochemical relapse or metastatic disease can result in further symptoms. We hypothesized that PC pts and partners would benefit from a clinical, educational, research-based approach to care that would focus on their specific needs. Methods: Funding from government agencies and philanthropic sources were used to establish a survivorship program in the urology clinic at the Vancouver Prostate Centre. A multi-disciplinary management team was formed to oversee the program. The Prostate Cancer Supportive Care (PCSC) Program is organized around 5 thematic modules 1) information about PC and primary treatment options (TX), 2) sexual health and intimacy (SH), 3) lifestyle changes in diet and exercise (DE), 4) managing the side effects of ADT, 5) incontinence and pelvic floor physiotherapy (PT). Group educational sessions (ED) are held 1-2 times monthly. Individual clinic appointments with SH and PT clinicians are also available. A program manager, clinic coordinator, and research assistant run PCSC on a day-to-day basis. Results: PCSC was initiated in January 2013. Urologists, nurses, pharmacists, and radiation oncologists referred patients to PCSC. Of 802 pts who enrolled (167 in 2013, 369 in 2014, and 266 in 2015 to date), to receive the quarterly newsletter, 626 (78%) chose to actively participate in at least one module (summarized in table). Feedback from couples, participating clinicians, and allied health personnel has been overwhelmingly positive. In addition, the PCSC population is proving to be a rich source of patients for research projects and training opportunities for young MDs. Conclusions: The results demonstrate that implementation of a disease specific survivorship program is feasible, well received and has other unanticipated benefits. Outcomes research and intervention protocols are in progress to address our hypothesis. [Table: see text]
Immunoprofile of Patients with Chronic Myeloid Leukemia Treated with Imatinib, Nilotinib or Dasatinib,
Authors: Yoshiki Hayashi, Hirohisa Nakamae, Takako Katayama, Takahiko Nakane, Hideo Koh, Mitsutaka Nishimoto, Mika Nakamae, Masahiro Yoshida, Masato Bingo, Hiroshi Okamura, Mizuki Aimoto, Masahiro Manabe, Takuro Yoshimura, Akiko Inaba, Satoshi Nanno, Kiyoyuki Hagihara, Yoshitaka Nakao, Yoshiki Terada, Masayuki Hino
Journal: Blood (2011)
A Novel Method of Regional Intravenous Delivery of AAV Vector to Skeletal Muscle Results in Correction of Canine Hemophilia B Phenotype.
Authors: Valder R. Arruda, Hansell H. Stedman, Joerg Schuettrumpf, Haiyan Jiang, Glenn Pierce, Timothy C. Nichols, Katherine A. High
Journal: Blood (2004)
First prospectively-designed outcome study in estrogen receptor (ER)+ breast cancer (BC) patients (pts) with N1mi or 1-3 positive nodes in whom treatment decisions in clinical practice incorporated the 21-gene recurrence score (RS) result
Authors: S.M. Stemmer, M. Steiner, S. Rizel, D. Geffen, B. Nisenbaum, T. Peretz, L. Soussan-Gutman, A. Bareket-Samish, K. Isaacs, O. Rosengarten, G. Fried, C. Svedman, S. Shak, N. Liebermann, N. Ben-Baruch
Journal: Annals of Oncology (2016)
Bcl-2, Mcl-1 and p53 Expression Confer Sensitivity to Bcl-2 Inhibitor ABT-737 in Multiple Myeloma.
Authors: Dharminder Chauhan, Mohan Brahmandam, Teru Hideshima, Klaus Podar, Nikhil Munshi, Noopur Raje, Kenneth C. Anderson
Journal: Blood (2006)
High-Dose Rituximab in the Conditioning Regimen Before Allogeneic Stem Cell Transplantation Reduces the Incidence of Acute Gvhd in B-Cell Lymphomas
Authors: Paolo Corradini, Barbara Sarina, Cristiana Carniti, Francesca Patriarca, Angelo Michele Carella, Alessandro Levis, Alberto Bosi, Michele Falda, Paolo Di Bartolomeo, Cecilia Olivares, Silvia Gimondi, Antonio Vendramin, Anna Dodero
Journal: Blood (2011)
How should we manage adults with persistent unexplained physical symptoms?
Authors: Madelon den Boeft, Nikki Claassen-van Dessel, Johannes C van der Wouden
Journal: BMJ (2017)

#### What you need to know Persistent physical symptoms are common and include those symptoms that last at least three months and are insufficiently explained by a medical condition after adequate examination and investigation.12 Examples include unexplained abdominal pain, musculoskeletal pains, fatigue, headache and dizziness. These symptoms are often associated with functional impairment and psychological distress among patients, and increase healthcare costs.2345 Observational studies in primary care report that women, especially those aged 35-45 years, more commonly present with these symptoms.25 Defining and categorising an unexplained symptom is tricky and disputed (see box 1).910 Sometimes symptoms fit criteria for somatoform or psychiatric disorders set out in the Diagnostic and Statistical Manual of Mental Disorders IV (DSM IV)6 or functional somatic syndromes such as irritable bowel syndrome. In other cases there is no label to offer the patient. #### Box 1: Terminology used in this article
Initial Results of a Multicenter, Phase II Study of Ibrutinib Plus FCR (iFCR) As Frontline Therapy for Younger CLL Patients
Authors: Matthew S. Davids, Haesook T. Kim, Danielle M. Brander, Jad Bsat, Alexandra Savell, Karen Francoeur, Jeffrey Hellman, Caron A. Jacobson, Ephraim Hochberg, Ronald Takvorian, Jeremy S. Abramson, David C. Fisher, Jennifer R. Brown
Journal: Blood (2016)
Is neutropenia a prognostic or a predictive factor for second line metastatic colorectal cancer (mCRC) patients (Pts)? Exploratory analysis from RAISE, a randomized, double-blind, phase III study of ramucirumab (RAM) + FOLFIRI vs placebo (PBO) + FOLFIRI
Authors: T.-E. Ciuleanu, G. Bodoky, R. Garcia-Carbonero, P. García Alfonso, E. Van Cutsem, K. Muro, D. Mytelka, O. Lipkovich, D. Ferry, A. Sashegyi, F. Nasroulah, J. Tabernero
Journal: Annals of Oncology (2016)
Prognostic Value of the Serum Free Light Chain Ratio in Patients with Newly Diagnosed Myeloma: Proposed Incorporation into the International Staging System.
Authors: Christine L.H. Snozek, Jerry A. Katzmann, Robert A. Kyle, Angela Dispenzieri, Dirk R. Larson, Raynell J. Clark, Philip R. Greipp, S. Vincent Rajkumar
Journal: Blood (2007)
Beta-lactam Skin Testing Without Minor Determinant Mixture and a Two Step Oral Amoxicillin Provocation Test in Patients with a History of Beta-lactam Allergy: A Pilot Study
Authors: Keerthi Reddy, Jan J. Gutierrez-Serano, Sonia Alvarez-Lopez, Alexei Gonzalez-Estrada
Journal: Journal of Allergy and Clinical Immunology (2017)
Rapid and Massive Expansion of Cord Blood Derived Cytokine Induced Killer (CIK) Cells: An Innovative Proposal for the Treatment of Leukemia Relapse after Cord Blood Transplantation.
Authors: Martino Introna, Marta Franceschetti, Alice Ciocca, Gianmaria Borleri, Elena Conti, Josee Golay, Alessandro Rambaldi
Journal: Blood (2006)
Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child
Authors: Patrick M Catalano, Kartik Shankar
Journal: BMJ (2017)

Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. At term, the risk of cesarean delivery and wound complications is increased. Postpartum, obese women have an increased risk of venous thromboembolism, depression, and difficulty with breast feeding. Because 50-60% of overweight or obese women gain more than recommended by Institute of Medicine gestational weight guidelines, postpartum weight retention increases future cardiometabolic risks and prepregnancy obesity in subsequent pregnancies. Neonates of obese women have increased body fat at birth, which increases the risk of childhood obesity. Although there is no unifying mechanism responsible for the adverse perinatal outcomes associated with maternal obesity, on the basis of the available data, increased prepregnancy maternal insulin resistance and accompanying hyperinsulinemia, inflammation, and oxidative stress seem to contribute to early placental and fetal dysfunction. We will review the pathophysiology underlying these data and try to shed light on the specific underlying mechanisms.
A pharmacokinetics and pharmacodynamics equivalence trial of proposed pegfilgrastim biosimilar, MYL-1401H vs EU neulasta® and US neulasta®
Authors: C.F. Waller, R. Tiessen, T. Lawrence, A. Shaw, M. Liu, R. Sharma, M. Baczkowski, M. Kothekar, R. Dias, A. Barve, E. Pennella
Journal: Annals of Oncology (2016)
Tolerance and Efficacy of L-Asparaginase during Induction of Extra-Nodal Natural Killer (NK/T) Lymphoma, Nasal Type, in Real-Life Experience
Authors: Salem Mansour, Louis Jacob, Sandy Amorim, Julien Potier, Pauline Brice, Laetitia Vercellino, Eric de Kerviler, Veronique Meignin, Sylvie Chevret, Catherine Thieblemont
Journal: Blood (2016)
Glucocorticoids Act both Antagonistically and Protagonistically on Type 2 Innate Lymphoid Cells (ILC2s) Depending upon the Stage of Development and the Cytokine Milieu
Authors: Sucai Liu, Mukesh Verma, Lidia Michalec, Donald Rollins, James Good, Magdalena M. Gorska, Rafeul Alam
Journal: Journal of Allergy and Clinical Immunology (2017)
Identification of Leukemia Associated Antigens From ANKRD17 and CDK4 Using Mass Spectrometry Based Screening,
Authors: Colleen McGary, Atim A. Enyenihi, Sally A. Hunsucker, Patricia A. Ropp, Tania Rodriguez-Cruz, Gregory Lizee, Gheath Alatrash, Gary L. Glish, Paul M. Armistead
Journal: Blood (2011)
Cefozoplan, Meropenem, or Imipenem-Cilastatin Versus Cefepime As an Empirical Therapy in High Risk Febrile Neutropenic Adult Patients: A Multicenter Prospective Randomized Trial
Authors: Takahiko Nakane, Toshiharu Tamaki, Kazuo Tamura, Isao Yoshida, Toshihiro Fukushima, Yoichi Tatsumi, Yasunori Nakagawa, Kazuo Hatanaka, Tsutomu Takahashi, Nobu Akiyama, Mitsune Tanimoto, Kazuma Ohyashiki, Akio Urabe, Tohru Masaoka, Akihisa Kanamaru
Journal: Blood (2012)
Effects of naloxone distribution alone or in combination with addiction treatment with or without pre-exposure prophylaxis for HIV prevention in people who inject drugs: a cost-effectiveness modelling study
Authors: Jennifer Uyei, David A Fiellin, Marianne Buchelli, Ramon Rodriguez-Santana, R Scott Braithwaite
Journal: The Lancet Public Health (2017)

In the USA, an epidemic of opioid overdose deaths is occurring, many of which are from heroin. Combining naloxone distribution with linkage to addiction treatment or pre-exposure prophylaxis (PrEP) for HIV prevention through syringe service programmes has the potential to save lives and be cost-effective. We estimated the outcomes and cost-effectiveness of five alternative strategies: no additional intervention, naloxone distribution, naloxone distribution plus linkage to addiction treatment, naloxone distribution plus PrEP, and naloxone distribution plus linkage to addiction treatment and PrEP.We developed a decision analytical Markov model to simulate opioid overdose, HIV incidence, overdose-related deaths, and HIV-related deaths in people who inject drugs in Connecticut, USA. Model input parameters were derived from published sources. We compared each strategy with no intervention, as well as simultaneously considering all strategies. Sensitivity analysis was done for all variables. Linkage to addiction treatment was referral to an opioid treatment programme for methadone. Endpoints were survival, life expectancy, quality-adjusted life-years (QALYs), number and percentage of overdose deaths averted, number of HIV-related deaths averted, total costs (in 2015 US$) associated with each strategy, and incremental cost per QALY gained.In the base-case analysis, compared with no additional intervention, the naloxone distribution strategy yielded an incremental cost-effectiveness ratio (ICER) of $323 per QALY, and naloxone distribution plus linkage to addiction treatment was cost saving compared with no additional intervention (greater effectiveness and less expensive). The most efficient strategies (ie, those conferring the greatest health benefit for a particular budget) were naloxone distribution combined with linkage to addiction treatment (cost saving), and naloxone distribution combined with PrEP and linkage to addiction treatment (ICER $95 337 per QALY) at a willingness-to-pay threshold of $100 000. In probabilistic sensitivity analysis, the combination of naloxone distribution, PrEP, and linkage to addiction treatment was the optimal strategy in 37% of iterations and the combination of naloxone distribution and linkage to addiction treatment was the optimal strategy in 34% of iterations.Naloxone distribution through syringe service programmes is cost-effective compared with syringe distribution alone, but when combined with linkage to addiction treatment is cost saving compared with no additional services. A strategy that combines naloxone distribution, PrEP, and linkage to addiction treatment results in greater health benefits in people who inject drugs and is also cost-effective.State of Connecticut Department of Public Health and the National Institute of Mental Health.
Ikaros-Dependent Downregulation of MYC with IMiDs in Myeloma (MM) Cells Is Mediated through the Depletion of the Acetylated Chromatin Reader BRD4 at Super-Enhancer Loci
Authors: Paola Neri, Ines Tagoug, Justin Simms, Ranjan Maity, Jacquelyn Babich, Victor Jimenez-Zepeda, Peter Duggan, Fariborz Kolvear, Jonathan J Keats, Leif Bergsagel, Nizar J Bahlis
Journal: Blood (2015)
Matrix Metalloproteinase 7: Role in Epithelial Integrity and Ciliogenesis in Pulmonary Fibrosis in a Mouse Model
Authors: Emma Westermann-Clark, Jutaro Fukumoto, Ramani Soundararajan, Conor C. Lynch, Richard F. Lockey, Narasaiah Kolliputi
Journal: Journal of Allergy and Clinical Immunology (2017)