tbuckley/cabot-search huggingface dataset:
Una grande epidemia di rosolia in Romania, 2003
Authors: A Rafila, M Marin, A Pistol, D Nicolaiciuc, E Lupulescu, A Uzicanin, S Reef
Journal: Eurosurveillance (2004)

Nel 2002-3 in Romania si e verificata una grande epidemia di rosolia, con piu di 115 000 casi riportati in tutto il paese, e un'incidenza di 531 casi per 100 000 abitanti. L'incidenza piu elevata e stata registrata nei bambini in eta scolare. Le coorti di ragazze adolescenti vaccinate nel 1998 e nel 2002 (quando era disponibile un vaccino contro la rosolia) presentavano tassi di incidenza considerevolmente inferiori (pl0,001) rispetto a quelli dei ragazzi della stessa classe di eta che non erano stati vaccinati. Nel 2003, dei 150 casi sospetti di sindrome da rosolia congenita (SRC), sette (4,6%) sono stati confermati per mezzo della presenza di anticorpi IgM anti-rosolia. In assenza di vaccino per controllare l'epidemia, e stato sviluppato un piano di risposta all'epidemia per migliorare la scoperta dei casi e per limitare la trasmissione del virus. Sono state condotte le seguenti attivita: sorveglianza delle donne in gravidanza con sospetta rosolia o storia di esposizione al virus della rosolia, con follow up degli esiti della gravidanza; rafforzamento della sorveglianza della SRC; rinforzo delle linee guida esistenti sul controllo dell'infezione per prevenire la trasmissione della malattia all'interno delle strutture assistenziali; sviluppo di una campagna rivolta alla popolazione. Nel maggio 2004 verra introdotto in Romania il vaccino contro morbillo-parotite-rosolia (MPR) per la vaccinazione di routine dei bambini tra i 12 e i 15 mesi, e si continuera a vaccinare le ragazze di 13-14 anni con il vaccino monovalente.
Epidemiología de la rubéola congénita en Grecia, 1994-2003
Authors: T Panagiotopoulos, T Georgakopoulou
Journal: Eurosurveillance (2004)

En 1993, Grecia experimento una gran epidemia de rubeola y sindrome de rubeola congenita (SRC). En este articulo se describe la epidemiologia de la rubeola y del SRC desde 1993, a partir de informacion obtenida de los datos de vigilancia y de estudios e informes publicados. La incidencia de rubeola disminuyo marcadamente despues de 1993, pero en 1999 se produjo un brote reducido, principalmente en adultos jovenes, y se declararon cuatro casos de SRC (4,0 por 100.000 nacimientos vivos). Un gran proporcion de la poblacion infantil griega recibe la vacuna contra la rubeola, mientras que la cobertura de adolescentes resulta insuficiente (60-80% en distintos estudios). Una proporcion importante de mujeres en edad fertil es susceptible a la rubeola (10-20% en zonas urbanas). Ello podria dar lugar a brotes locales o mas extendidos. Esta situacion pone de manifiesto la necesidad de adoptar una politica preventiva integral.
Patient-reported endocrine symptoms, sexual functioning, and quality of life (QoL) in the IBCSG TEXT and SOFT trials: Adjuvant treatment with exemestane (E) plus ovarian function suppression (OFS) versus tamoxifen (T) plus OFS in premenopausal women with hormone receptor-positive (HR+) early breast cancer (BC).
Authors: Juerg Bernhard, Weixiu Luo, Karin Ribi, Marco Colleoni, Harold J. Burstein, Carlo Tondini, Graziella Pinotti, Simon Spazzapan, Thomas Ruhstaller, Fabio Puglisi, Lorenzo Pavesi, Vani Parmar, Meredith M. Regan, Olivia Pagani, Gini F. Fleming, Prudence A. Francis, Alan S. Coates, Richard D. Gelber, Aron Goldhirsch, Barbara Walley
Journal: Journal of Clinical Oncology (2014)

557 Background: Little is known about endocrine symptoms, QoL and sexual function in premenopausal women with BC receiving adjuvant endocrine therapy. TEXT and SOFT are the first trials providing patient-reported data in this population. Methods: From Nov 2003 to Apr 2011, 4096 premenopausal patients (pts) with HR+ BC were enrolled and included in the QoL analysis of the randomized phase III trials, TEXT and SOFT, to receive adjuvant treatment with 5 yrs E+OFS or T+OFS. Chemotherapy (chemo) was optional in both trials; received concurrently with OFS after randomization in TEXT and prior to randomization in SOFT, with women eligible if they remained premenopausal after completing chemo. Pts completed a questionnaire consisting of global and symptom-specific indicators at baseline, every 6 months for the first 24 months, and annually yrs 3 to 6. Differences in change of QoL from baseline between the two treatments were tested at short-, mid-, and long-term (6, 24 and 60 months post-randomization, respectively) for 3 global QoL and 5 symptom indicators using mixed models with repeated measures. Results: Pts on T+OFS were significantly more affected by hot flushes than E+OFS, with treatment difference persisting over time (each p<.05). The change of hot flushes from baseline improved over time for both treatments. Throughout treatment, pts on E+OFS reported more vaginal dryness and greater loss of sexual interest, while T+OFS reported more vaginal discharge (each p<.0001). The difference between treatments in bone/joint pain was most pronounced in the short-term in favor of T+OFS, but a difference persisted (each p<.0001). Changes of global QoL indicators (mood, physical wellbeing, and coping effort) from baseline were similar between treatments over the whole treatment period. Conclusion: Overall from a QoL perspective, there is no strong indication to favor either E+OFS or T+OFS. The differential effects of the two treatments on endocrine symptoms burden need to be addressed with patients individually. Clinical trial information: NCT00066783/NCT00066690.
TCT-592 Primary Left Ventricular Unloading Infarct Size by Increasing Myocardial Levels of Stromal Derived Factor One Alpha (SDF1a) in Acute Myocardial Infarction
Authors: Shiva Annamalai, Michele Esposito, Hyunji Koo, Peter Natov, Lara Reyelt, Courtney Bogins, Kevin Morine, Richard Karas, Navin Kapur
Journal: Journal of the American College of Cardiology (2017)
Le botulisme au Royaume-Uni
Authors: M Brett
Journal: Eurosurveillance (1999)

Clostridium botulinum est une bacterie anaerobie produisant des spores qui se developpe en l'absence d'oxygene. Elle est a l'origine de trois formes epidemiologiques principales de botulisme : d'origine alimentaire, botulisme du nourrisson, et botulisme par blessure. Le botulisme d'origine alimentaire est une intoxication due a l'ingestion de la neurotoxine preformee dans un aliment apres developpement de C. botulinum. En revanche, les deux autres formes de botulisme sont dues au developpement de germes de C. botulinum et a la liberation de toxines in vivo. Dans le cas du botulisme par blessure, les germes se forment et produisent des neurotoxines au niveau d’abces cutanes chez les utilisateurs de drogues injectables, ou d’une plaie traumatique importante. Le botulisme du nourrisson apparait suite a l’ingestion de spores de C. botulinum qui colonisent l'intestin et produisent des neurotoxines, qui sont alors absorbees via le canal intestinal.
Activity and safety of AZD3759 in EGFR-mutant non-small-cell lung cancer with CNS metastases (BLOOM): a phase 1, open-label, dose-escalation and dose-expansion study
Authors: Myung-Ju Ahn, Dong-Wan Kim, Byoung Chul Cho, Sang-We Kim, Jong Seok Lee, Jin-Seok Ahn, Tae Min Kim, Chia-Chi Lin, Hye Ryun Kim, Thomas John, Steven Kao, Jonathan W Goldman, Wu-Chou Su, Ronald Natale, Sarit Rabbie, Bryony Harrop, Philip Overend, Zhenfan Yang, James Chih-Hsin Yang
Journal: The Lancet Respiratory Medicine (2017)
Similarity and Difference of Resting Distal to Aortic Coronary Pressure and Instantaneous Wave-Free Ratio
Authors: Joo Myung Lee, Jonghanne Park, Doyeon Hwang, Chee Hae Kim, Ki Hong Choi, Tae-Min Rhee, Yaliang Tong, Jin Joo Park, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Bon-Kwon Koo
Journal: Journal of the American College of Cardiology (2017)
TCT-48 Potential “Intraplaque Hemorrhage” Pattern Assessed by Combined Intravascular Ultrasound and Optical Coherence Tomography
Authors: Tetsumin Lee, Gary Mintz, Mitsuaki Matsumura, Masahiro Hoshino, Eisuke Usui, Yoshihisa Kanaji, Tadashi Murai, Taishi Yonetsu, Tsunekazu Kakuta, Akiko Maehara
Journal: Journal of the American College of Cardiology (2017)
TCT-515 The Impact of Trans-catheter Aortic Valve Replacement on Coexisting Mitral Regurgitation
Authors: Akihiro Kobayashi, Sean Sliman, Mohamad Lazkani, Shishir Murarka, Soundos Moualla, Divya Ratan Verma, Michael Morris, Ashish Pershad
Journal: Journal of the American College of Cardiology (2017)
The Value of Preterm Infant Environmental Health Cohorts
Authors: Annemarie Stroustrup, Susan L. Teitelbaum, Judy L. Aschner
Journal: JAMA Pediatrics (2017)

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Vigilancia de la gripe en la región noroeste de Inglaterra, 2001-02
Authors: C M Regan, W Sopwith, M Ashton, Q Syed, M Painter, K Mutton, K Paver
Journal: Eurosurveillance (2002)

En la region noroeste de Inglaterra se ha creado una red centinela local de medicos generales para la vigilancia de la gripe. En el invierno 2001-02, las tasas de consultas por sindromes gripales (influenza-like-illness; ILI) fueron bajas, pero la red de vigilancia pudo demostrar variaciones subregionales en el momento de aparicion de los picos de actividad gripal, asi como la infeccion de distintos grupos de edad. Ello sugiere que la red puede ayudar a planificar mejor las necesidades invernales en el servicio de salud de la region noroeste.
Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology
Authors: Joost Petrus Gerardus Sluijter, Sean Michael Davidson, Chantal M Boulanger, Edit Iren Buzás, Dominique Paschalis Victor de Kleijn, Felix Benedikt Engel, Zoltán Giricz, Derek J Hausenloy, Raj Kishore, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Cinzia Perrino, Fabrice Prunier, Susmita Sahoo, Ray Michel Schiffelers, Rainer Schulz, Linda Wilhelmina Van Laake, Kirsti Ytrehus, Péter Ferdinandy
Journal: Cardiovascular Research (2017)

Extracellular vesicles (EVs)-particularly exosomes and microvesicles (MVs)-are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction. They also appear to mediate some of the paracrine effects of cells, and have therefore been proposed as a potential alternative to cell-based regenerative therapies. Moreover, EVs of different sources may be useful biomarkers of cardiovascular disease identities. However, the methods used for the detection and isolation of EVs have several limitations and vary widely between studies, leading to uncertainties regarding the exact population of EVs studied and how to interpret the data. The number of publications in the exosome and MV field has been increasing exponentially in recent years and, therefore, in this ESC Working Group Position Paper, the overall objective is to provide a set of recommendations for the analysis and translational application of EVs focussing on the diagnosis and therapy of the ischaemic heart. This should help to ensure that the data from emerging studies are robust and repeatable, and optimize the pathway towards the diagnostic and therapeutic use of EVs in clinical studies for patient benefit.
TCT-588 Percutaneous Short-Term Active Mechanical Support Devices in Cardiogenic Shock: A Systematic Review and Collaborative Meta-Analysis of Randomized Trials
Authors: Suzanne de Waha, Alexander Jobs, Dagmar Ouweneel, Jose PS. Henriques, Melchior Seyfarth, Steffen Desch, Ingo Eitel, Janine Pöss, Georg Fuernau, Holger Thiele
Journal: Journal of the American College of Cardiology (2017)
Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma in Relapse after Autologous Transplantation: A Single Institution Experience with Matched Related Donors
Authors: Gil Brás, Carlos Vaz, Luís Leite, Rosa Branca, Fernando Campilho, Susana Roncón, Antonio M. Campos
Journal: Blood (2016)
Case 32-2017
Authors: Kerri Palamara, Amulya Nagarur, Florian J. Fintelmann, Minna J. Kohler, Frank B. Cortazar
Journal: New England Journal of Medicine (2017)

A 64-year-old man presented with headache, dyspnea, wheezing, cough, and night sweats. He had eosinophilia, sinusitis on CT, and abnormal results on pulmonary-function tests, including an elevated fraction of exhaled nitric oxide. Diagnostic tests were performed.
TCT-276 Radial Artery Patency In Japanese and Non-japanese Patients After Transradial Coronary Angiography and Intervention With 6 French Slender or Standard 5 French Sheaths. A Substudy From RAP and BEAT (Radial Artery Patency and Bleeding, Efficacy, Adverse evenT) Randomised Multicenter Trial.
Authors: Adel Aminian, Shigeru Saito, Akihiko Takahashi, Ivo Bernat, Robert L. Jobe, Takashi Kajiya, Ian Gilchrist, Yves Louvard, Ferdinand Kiemeneij, Niels van Royen, Maarten van Leeuwen, Yamazaki Seiji, Takashi Matsukage, Sunil Rao
Journal: Journal of the American College of Cardiology (2017)
Rapid Laboratory Identification of <i>Neisseria meningitidis</i> Serogroup C as the Cause of an Outbreak — Liberia, 2017
Authors: Jaymin C. Patel, Josiah George, Jeni Vuong, Caelin C. Potts, Catherine Bozio, Thomas A. Clark, Jerry Thomas, Joshua Schier, Arthur Chang, Jessica L. Waller, Maureen H. Diaz, Melissa Whaley, Laurel T. Jenkins, Serena Fuller, Desmond E. Williams, John T. Redd, Ray R. Arthur, Fahn Taweh, Yatta Vera Walker, Patrick Hardy, Maxwell Freeman, Victoria Katawera, Gulu Gwesa, Miatta Z. Gbanya, Peter Clement, Henry Kohar, Mardia Stone, Mosoka Fallah, Tolbert Nyenswah, Jonas M. Winchell, Xin Wang, Lucy A. McNamara, E. Kainne Dokubo, LeAnne M. Fox
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

On April 25, 2017, a cluster of unexplained illness and deaths among persons who had attended a funeral during April 21-22 was reported in Sinoe County, Liberia (1). Using a broad initial case definition, 31 cases were identified, including 13 (42%) deaths. Twenty-seven cases were from Sinoe County (1), and two cases each were from Grand Bassa and Monsterrado counties, respectively. On May 5, 2017, initial multipathogen testing of specimens from four fatal cases using the Taqman Array Card (TAC) assay identified Neisseria meningitidis in all specimens. Subsequent testing using direct real-time polymerase chain reaction (PCR) confirmed N. meningitidis in 14 (58%) of 24 patients with available specimens and identified N. meningitidis serogroup C (NmC) in 13 (54%) patients. N. meningitidis was detected in specimens from 11 of the 13 patients who died; no specimens were available from the other two fatal cases. On May 16, 2017, the National Public Health Institute of Liberia and the Ministry of Health of Liberia issued a press release confirming serogroup C meningococcal disease as the cause of this outbreak in Liberia.
FUSION IMAGING OF COMPUTED TOMOGRAPHY AND 3D ECHOCARDIOGRAPHY: FEASIBILITY OF COMBINED ASSESSMENT OF CORONARY ANATOMY AND MYOCARDIAL FUNCTION
Authors: Francesco Maffessanti, Victor Mor-Avi, Karima Addetia, Gillian Murtagh, Lynn Weinert, Amit Patel, Roberto Lang
Journal: Journal of the American College of Cardiology (2014)
Complement-Activating Anti-HLA Antibodies in Kidney Transplantation: Allograft Gene Expression Profiling and Response to Treatment
Authors: Carmen Lefaucheur, Denis Viglietti, Luis G. Hidalgo, Lloyd E. Ratner, Serena M. Bagnasco, Ibrahim Batal, Olivier Aubert, Babak J. Orandi, Federico Oppenheimer, Oriol Bestard, Paolo Rigotti, Anna V. Reisaeter, Nassim Kamar, Yvon Lebranchu, Jean-Paul Duong Van Huyen, Patrick Bruneval, Denis Glotz, Christophe Legendre, Jean-Philippe Empana, Xavier Jouven, Dorry L. Segev, Robert A. Montgomery, Adriana Zeevi, Philip F. Halloran, Alexandre Loupy
Journal: Journal of the American Society of Nephrology (2017)

Export Complement-activating anti-HLA donor-specific antibodies (DSAs) are associated with impaired kidney transplant outcome; however, whether these antibodies induce a specific rejection phenotype and influence response to therapy remains undetermined. We prospectively screened 931 kidney recipients for complement-activating DSAs and used histopathology, immunostaining, and allograft gene expression to assess rejection phenotypes. Effector cells were evaluated using in vitro human cell cultures. Additionally, we assessed the effect of complement inhibition on kidney allograft rejection phenotype and the clinical response to complement inhibition in 116 independent kidney recipients with DSAs at transplant receiving rejection prophylaxis with eculizumab or standard of care (plasma exchange and intravenous Ig) at ten international centers. The histomolecular rejection phenotype associated with complement-activating DSA was characterized by complement deposition and accumulation of natural killer cells and monocytes/macrophages in capillaries and increased expression of five biologically relevant genes (CXCL11, CCL4, MS4A7, MS4A6A, and FCGR3A) indicative of endothelial activation, IFNγ response, CD16-mediated natural killer cell activation, and monocyte/macrophage activation. Compared with standard of care, eculizumab specifically abrogated this histomolecular rejection phenotype and associated with a decreased 3-month rejection incidence rate in patients with complement-activating DSAs (56%; 95% confidence interval [95% CI], 38% to 74% versus 19%; 95% CI, 8% to 35%; P=0.001) but not in those with noncomplement-activating DSAs (9%; 95% CI, 2% to 25% versus 13%; 95% CI, 2% to 40%; P=0.65). In conclusion, circulating complement-activating anti-HLA DSAs are associated with a specific histomolecular kidney allograft rejection phenotype that can be abrogated by complement inhibition.
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Authors: David Lagares, Parisa Ghassemi-Kakroodi, Caroline Tremblay, Alba Santos, Clemens K Probst, Alicia Franklin, Daniela M Santos, Paula Grasberger, Neil Ahluwalia, Sydney B Montesi, Barry S Shea, Katharine E Black, Rachel Knipe, Meryem Blati, Murray Baron, Brian Wu, Hassan Fahmi, Rajiv Gandhi, Annie Pardo, Moisés Selman, Jiangping Wu, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Andrew M Tager, Mohit Kapoor
Journal: Nature Medicine (2017)
TCT-144 High Pulmonary Vascular Resistance is Associated with Higher Mortality in Transcatheter Aortic Valve Replacement Patients with Pulmonary Hypertension
Authors: Gavin Hickey, Dustin Kliner, Jeffrey Xu, Floyd Thoma, Andrew Althouse, Joon Lee, John Schindler, Thomas Gleason, Joao Cavalcante
Journal: Journal of the American College of Cardiology (2017)
TCT-753 Long-Term Comparison of Platinum Chromium Everolimus-Eluting and Cobalt Chromium Zotarolimus-Eluting Stents: Three-Year Outcome of the HOST-ASSURE Randomized Trial
Authors: Chee Hae Kim, Kyung Woo (KW) Park, Jeehoon Kang, Si-Hyuck Kang, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Eun-Seok Shin, Ju Hyeon Oh, Sang-Hyun Kim, Kyung-Kuk Hwang, Keon Woong Moon, Seung-Ho Hur, In-Ho Chae, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2017)
Abstract SY03-03: Modulating innate and adaptive immunity through the manipulation of dendritic cells
Authors: Nina Bhardwaj
Journal: Cancer Research (2010)

Abstract Dendritic cells (DC) are potent antigen presenting cells used in clinical trials to treat cancer and infectious diseases such as HIV. We have performed two types of clinical trials to evaluate their immunogenicity in vivo. First, we compared DC to conventional vaccine adjuvants. HLA-A2+ resected melanoma patients were enrolled into a randomized clinical trial to compare vaccines comprised of six HLA-A2-restricted peptide antigens and a foreign protein, KLH, either pulsed onto cytokine-matured, monocyte-derived DCs or emulsified in the mineral oil adjuvant Montanide ISA 51. The frequency, magnitude and quality of antigen-specific cellular immune responses in peripheral blood were found to be greater in patients receiving the Montanide vaccine. Furthermore, the primed cells were functionally superior, indicating a need to improve current DC-based vaccine approaches. Preclinical studies in mice were undertaken to evaluate the mechanism by which DC prime T cells. Contrary to previous assumptions, we found that DC vaccines have an insignificant role in directly priming CD8+ T cells, but instead function primarily as vehicles for transferring antigens to endogenous antigen presenting cells, which are responsible for the subsequent activation of T cells. This reliance on endogenous immune cells may explain the limited success of current DC vaccines to treat cancer and offers new insight into how these therapies can be improved. Future approaches will focus on creating DC vaccines that are more effective at directly priming T cells, by altering maturation factors, or abrogating the tumor induced suppression of endogenous DCs In a second approach, we used TLR agonists targeting TLR 7, 8 and/or 9 to prime immunity to melanoma associated antigens in a series of clinical trials. They include imiquimod, resiquimod and CpG, agonists for TLR7 and/or TLR 8 and TLR9 respectively. These adjuvants when combined with the cancer testis antigen NY-ESO-1, induced integrated immune responses which were characterized by the induction of both CD4+ and CD8+ T cell immunity as well as antigen-specific antibodies in patients with resected melanoma. Strategies to optimize these various approaches to induce immunity in cancer and other chronic diseases will be discussed. Citation Format: Nina Bhardwaj. Modulating innate and adaptive immunity through the manipulation of dendritic cells [abstract]. In: Proceedings of the AACR 101st Annual Meeting 2010; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr SY03-03
O tifo murino estará a re-emergir em Portugal?
Authors: F Bacellar, I Lencastre, A R Filipe
Journal: Eurosurveillance (1998)

O tifo murino ou tifo endemico e uma doenca infecciosa provocada pela Rickettsia typhi (por vezes chamada R. mooseri), clinicamente muito parecida com o tifo epidemico.