tbuckley/cabot-search huggingface dataset:
An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis
Authors: Kimita Suyama, Jiahong Yao, Huizhi Liang, Outhiriaradjou Benard, Olivier D. Loudig, Dulguun Amgalan, Wendy M. McKimpson, Greg R. Phillips, Jeffrey Segall, Yihong Wang, Susan Fineberg, Larry Norton, Richard N. Kitsis, Rachel B. Hazan
Journal: Cancer Research (2017)

Abstract The Akt pathway is a well-known promoter of tumor malignancy. Akt3 is expressed as two alternatively spliced variants, one of which lacks the key regulatory serine 472 phosphorylation site. Whereas the function of full-length Akt3 isoform (Akt3/+S472) is well-characterized, that of Akt3/−S472 isoform remains unknown. Despite being expressed at a substantially lower level than Akt3/+S472 in triple-negative breast cancer cells, specific ablation of Akt3/−S472 enhanced, whereas overexpression, suppressed mammary tumor growth, consistent with a significant association with patient survival duration relative to Akt3/+S472. These effects were due to striking induction of apoptosis, which was mediated by Bim upregulation, leading to conformational activation of Bax and caspase-3 processing. Bim accumulation was caused by marked endocytosis of EGF receptors with concomitant ERK attenuation, which stabilizes BIM. These findings demonstrate an unexpected function of an endogenously expressed Akt isoform in promoting, as opposed to suppressing, apoptosis, underscoring that Akt isoforms may exert dissonant functions in malignancy. Significance: These results illuminate an unexpected function for an endogenously expressed Akt isoform in promoting apoptosis, underscoring the likelihood that different Akt isoforms exert distinct functions in human cancer. Cancer Res; 78(1); 103–14. ©2017 AACR.
TCT-425 Impact of cerebral protection in aortic stenosis patients treated with transcatheter aortic valve replacement on functional and structural integrity of the brain: results of a combined patient-level analysis of three randomized controlled trials
Authors: Axel Linke, Samir Kapadia, Susheel Kodali, Raj Makkar, Maria Alu, Peyton Willert, Michael Dwyer, Robert Zivadinov, Lisa Thackeray, Roseann White, Azin Parhizgar, Thomas Engels, Roxana Mehran, Stephan Haussig, Felix Woitek, Norman Mangner, Martin Leon, Nicolas Van Mieghem
Journal: Journal of the American College of Cardiology (2017)
How dare you not recognize the role of my contempt? Insight from experimental psychopathology
Authors: Alessandro Grecucci, Jon Frederickson, Remo Job
Journal: Behavioral and Brain Sciences (2017)

Gervais & Fessler argue that contempt is an attitude state defined as a lack of respect that potentiates the activation and deactivation of two different clusters of emotions. However, clinical and experimental findings do not support this view. We provide evidence that contempt is not an emotion, nor an attitude, but a reactive defensive mechanism evolved to help individuals avoid shame.
Long-term Outcomes of Multiple Arterial Coronary Artery Bypass Grafting
Authors: Aihua Pu, Lillian Ding, Jungwon Shin, Joel Price, Peter Skarsgard, Daniel R. Wong, John Bozinovski, Guy Fradet, James G. Abel
Journal: JAMA Cardiology (2017)

Although the long-term survival advantage of multiple arterial grafting (MAG) vs the standard use of left internal thoracic artery (LITA) supplemented by saphenous vein grafts (LITA+SVG) has been demonstrated in several observational studies, to our knowledge its safety and other long-term clinical benefits in a large, population-based cohort are unknown.To compare the safety and long-term outcomes of MAG vs LITA+SVG among overall and selected subgroups of patients.In this population-based observational study, we included 20 076 adult patients with triple-vessel or left-main disease who underwent primary isolated coronary artery bypass grafting (MAG, n = 5580; LITA+SVG, n = 14 496) in the province of British Columbia, Canada, from January 2000 to December 2014, with follow-up to December 2015. We performed propensity-score analyses by weighting and matching and multivariable Cox regression to minimize treatment selection bias.Multiple arterial grafting or LITA+SVG.Mortality, repeated revascularization, myocardial infarction, heart failure, and stroke.Of 5580 participants who underwent MAG, 586 (11%) were women and the mean (SD) age was 60 (8.7) years. Of 14 496 participants who underwent LITA+SVG, 2803 (19%) were women and the mean (SD) age was 68 (8.9) years. The median (interquartile range) follow-up time was 9.1 (5.1-12.6) years and 8.1 (4.5-11.7) years for the groups receiving MAG and LITA+SVG, respectively. Compared with LITA+SVG, MAG was associated with reduced mortality rates (hazard ratio [HR], 0.79; 95% CI, 0.72-0.87) and repeated revascularization rates (HR, 0.74; 95% CI, 0.66-0.84) in 15-year follow-up and reduced incidences of myocardial infarction (HR, 0.63; 95% CI, 0.47-0.85) and heart failure (HR, 0.79; 95% CI, 0.64-0.98) in 7-year follow-up. The long-term benefits were coherent by all 3 statistical methods and persisted among patient subgroups with diabetes, obesity, moderately impaired ejection fraction, chronic obstructive pulmonary disease, peripheral vascular disease, or renal disease. Multiple arterial grafting was not associated with increased morbidity or mortality rates at 30 days overall or within patient subgroups.Compared with LITA+SVG, MAG is associated with reduced mortality, repeated revascularization, myocardial infarction, and heart failure among patients with multivessel disease who are undergoing coronary artery bypass grafting without increased mortality or other adverse events at 30 days. The long-term benefits consistently observed across multiple outcomes and subgroups support the consideration of MAG for a broader spectrum of patients who are undergoing coronary artery bypass grafting in routine practice.
Abstract 13853: Routine Follow Up Coronary Angiography versus Clinical Follow Up Only in Patients With Dyslipidemia Following Percutaneous Coronary Intervention With Drug-eluting Stents: 3-year Clinical Follow Up Results
Authors: Seung Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Circulation (2015)

Background: It is unclear whether the routine follow up (FU) coronary angiography (CAG) regardless of patient’s symptoms after successful percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) in patients (pts) with dyslipidemia is beneficial or not. Methods: The study population consisted of 554 consecutive dyslipidemia pts underwent PCI with unrestricted utilization of DESs from January 2004 to May 2011. Routine FU CAG was performed between 6 to 9 months following index PCI and was decided by individual physician’s discretion. Rests of the pts were clinically followed and ischemic driven events were captured. Clinical events including mortality, myocardial infarction and clinically driven PCI before 9 months were excluded in both groups. Cumulative clinical outcomes up to 3 years were compared between the Routine CAG group (n=329 pts) and the Clinical FU group (n= 225 pts). To adjust potential confounders, a propensity score matched (PSM) analysis was performed using the logistic regression model. Results: After PSM analysis, 2 propensity-matched groups (165 pairs, n = 330 pts, C-statistic=0.718) were generated and, the baseline characteristics of the two groups were balanced. At 3 years, the incidence of repeat revascularization and major adverse cardiac events (MACEs) was higher in the Routine CAG group than the control group (Table). Conclusions: Despite the expected beneficial effects, routine FU CAG following index PCI with DESs in dyslipidemia pts was associated with higher incidence of repeat PCI and MACE up to 3 years.
Gastroenterite a SRSV-1 em Malta - 1995
Authors: D Falzon
Journal: Eurosurveillance (1996)

Os “Small Round Structured Virus” (SRSV), sao causa conhecida de gastroenterites epidemicas em instituicoes, sendo responsaveis por 54% dos surtos de transmissao pessoa-a-pessoa e 6% dos surtos de intoxicacoes alimentares na Inglaterra e Pais de Gales (1). A infeccao e habitualmente transmitida de pessoa-a-pessoa e tambem pelos alimentos, agua e objectos inanimados. O periodo de incubacao e de 10 a 50 horas e o periodo de infectividade perdura desde o inicio da doenca aguda ate 48 horas apos o desaparecimento dos sintomas (2). Este relatorio decreve um importante surto de gastroenterite a SRSV que ocorreu num externato privado (escola A) em Malta. O Departamento de Saude Publica em Malta foi alertado a 23 de Novembro de 1995 e conduziu a investigacao necessaria para a identificacao da origem do surto e para controlo da sua disseminacao.
Relationships Between Dosage and Rate of Tumor Induction by Ultraviolet Radiation
Authors: Harold F. Blum, Hugh G. Grady, John S. Kirby-Smith
Journal: JNCI Journal of the National Cancer Institute (1942)

Relationships Between Dosage and Rate of Tumor Induction by Ultraviolet Radiation Get access Harold F. Blum, Harold F. Blum senior pharmacologist Search for other works by this author on: Oxford Academic PubMed Google Scholar Hugh G. Grady, Hugh G. Grady acting assistant surgeon Search for other works by this author on: Oxford Academic PubMed Google Scholar John S. Kirby-Smith John S. Kirby-Smith assistant physicist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 3, Issue 1, August 1942, Pages 91–97, https://doi.org/10.1093/jnci/3.1.91 Published: 01 August 1942
TCT-585 Effect of high dose of Rosuvastatin on the serum concentration of inflammatory markers in the acute phase of percutaneous coronary intervention with metal stent implantation
Authors: Juliano Slhessarenko, Jose Costa, Mario Hirata, Alexandre Abizaid, Renata Slhessarenko, Elisa Mieko Higa, José Eduardo Souza
Journal: Journal of the American College of Cardiology (2017)
Reliability and Minimal Clinically Important Differences of FVC. Results from the Scleroderma Lung Studies (SLS-I and SLS-II)
Authors: Suzanne Kafaja, Philip J. Clements, Holly Wilhalme, Chi-hong Tseng, Daniel E. Furst, Grace Hyun Kim, Jonathan Goldin, Elizabeth R. Volkmann, Michael D. Roth, Donald P. Tashkin, Dinesh Khanna, Ann Arbor, D. Khanna, Los Angeles, P. J. Clements, D. P. Tashkin, R. Elashoff, J. Goldin, M. Roth, D. Furst, K. Bulpitt, W.-L. J. Chung, S. Viasco, M. Sterz, L. Woolcock, X. Yan, J. Ho, S. Vasunilashorn, I. da Costa, J. R. Seibold, D. J. Riley, J. K. Amorosa, V. M. Hsu, D. A. McCloskey, J. E. Wilson, J. Varga, D. Schraufnagel, A. Wilbur, D. Lapota, S. Arami, P. Cole-Saffold, R. Simms, A. Theodore, P. Clarke, J. Korn, K. Tobin, M. Nuite, R. Silver, M. Bolster, C. Strange, S. Schabel, E. Smith, J. Arnold, K. Caldwell, M. Bonner, R. Wise, F. Wigley, B. White, L. Hummers, M. Bohlman, A. Polito, G. Leatherman, E. Forbes, M. Daniel, V. Steen, C. Read, C. Cooper, S. Wheaton, A. Carey, A. Ortiz, M. Mayes, E. Parsley, S. Oldham, T. Filemon, S. Jordan, M. Perry, None K. Connolly, J. Golden, P. Wolters, R. Webb, J. Davis, C. Antolos, C. Maynetto, B. Fessler, M. Olman, C. Sanders, L. Heck, T. Parkhill, N. Rothfield, M. Metersky, R. Cobb, M. Aberles, F. Ingenito, E. Breen, M. Mayes, K. Mubarak, J. L. Granda, J. Silva, Z. Injic, R. Alexander, D. Furst, S. Springmeyer, S. Kirkland, J. Molitor, R. Hinke, A. Mondt, T. Thompson, S. Rounds, M. Weinstein, B. Thompson, H. Paulus, S. Levy, D. Martin, E. Kissin, F. Y. Cheong, G. Marlis, J. Mason-Berry, P. Saffold, M. Rodriguez, L. Guzman, J. Brook, G. Ibrahim, K. Largaespada, C. Fridley, M. Zulmastashvili, A. Manu, S. Moore, L. Hummers, G. Leatherman, F. N. Hant, K. Gibson, M. Morrison, H. Donnelly, C. Marlin, J. Gangar, D. A. McCloskey, A. Eller, D. Leong, M. Lalosh, J. Obata, S. Arami, D. Franklin, E. Schiopu, M. Benedict-Blue, V. Leone, J. Shaw, F. Tan, M. Perry, J. Anderson, A. Saulino, P. Carey, M. Esplin, P. Carlson
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

To assess the reliability and the minimal clinically important differences (MCID) for FVC% predicted in the Scleroderma Lung Study I and II.
Prevalence and clinical correlation of programmed cell death 1 ligand (PD-L1) expression in patients with resected non-small cell lung cancer (NSCLC): Results from the European Thoracic Oncology Platform (ETOP) Lungscape cohort.
Authors: Keith Kerr, Erik Thunnissen, Urania Dafni, Alex Soltermann, Stephen P. Finn, Lukas Bubendorf, Eric Verbeken, Wojciech Biernat, Arne Warth, Antonio Marchetti, Ernst-Jan M. Speel, Saraswati Pokharel, Anne Marie Quinn, Kim Monkhorst, Atilio Navarro, Line Bille Madsen, Varvara Polydoropoulou, Rosita Kammler, Solange Peters, Rolf A. Stahel
Journal: Journal of Clinical Oncology (2017)

8516 Background: Conflicting data exists on the potential prognostic impact of PD-L1 expression in NSCLC. The Lungscape project, a fully annotated large biobank of resected stage I-III NSCLC, allows detailed analysis of this issue. Methods: Prevalence of PD-L1 positivity and its association with clinicopathological characteristics and patient outcome - Relapse-free Survival (RFS), Time-to-Relapse (TTR) and Overall Survival (OS) - was explored in the ETOP Lungscape cohort. PD-L1 expression was assessed on tissue microarrays (TMAs) using the DAKO 28-8 immunohistochemistry assay. Positivity cut-off points of ≥1%, 5% and 50% for neoplastic cell membrane staining were considered. Results: PD-L1 data were available for 2182 patients, from 15 ETOP centers, with median follow-up 4.8 years; 1191 patients still alive; median age 66 years; 64% male, 32/54/11% for current/former/never smokers; 49/29/22% for stages I/II/III; 51/42/4/3% adenocarcinomas (AC)/squamous cell (SCC) /large cell and sarcomatoid (LCS)/other. Median RFS/TTR/OS were 53/99/69 months (AC: 52/84/72, SCC: 54/not reached/64; and LSC 52/103/74). PD-L1 prevalence with 1% cut-off was, overall: 43%, 95% confidence interval (95%CI): 41-46; (AC: 42%, 95%CI: 39-46; SCC: 44%, 95%CI: 40-47; and LCS: 53%, 95%CI: 42-65), while for 5% threshold, prevalence was 34%, 95%CI: 32-36. PD-L1 1% positivity was a significant predictor only for AC: HR RFS: + vs - = 0.82; 95%CI: 0.69-0.97, HR TTR: + vs - = 0.83; 95%CI: 0.68-1.01, HR OS: + vs - = 0.83; 95%CI: 0.69-1.01 (adjusted p = 0.024, 0.064, 0.063 respectively). This effect is found also for the 5% cut-off, and preserved in the overall model including all histologies. Using the 50% cut-off, PD-L1 positivity was detected in 17% of patients; 95%CI: 15-18, but was no longer a significant predictor of outcome, overall and by histology type. Conclusions: PD-L1 positivity (1% and 5% cut-offs) was present in more than one third of resected NSCLC and was associated with a better prognosis for AC patients.
High expression of IRE1 in lung adenocarcinoma is associated with a lower rate of recurrence
Authors: Toshio Sakatani, Keita Maemura, Noriko Hiyama, Yosuke Amano, Kousuke Watanabe, Hidenori Kage, Masashi Fukayama, Jun Nakajima, Takahide Nagase, Daiya Takai
Journal: Annals of Oncology (2017)
Genetic modification of smoking-related colorectal cancer: Results from the Singapore Chinese Health Study
Authors: Heather Nelson, Woon Puay Koh, David van den Berg, Renwei Wang, Mimi Yu
Journal: Cancer Research (2008)

1902   Heterocyclic aromatic amines (HAA) are colorectal carcinogens found in both cigarette smoke and certain types of charred meat. While a consistent association between cigarette smoking and colorectal carcinoma has been established, the role of GST polymorphisms as modifiers of this relationship remains unclear. Conflicting data on the role of GSTs in colorectal carcinogenesis may stem from the complex patterns of exposure to HAA from both diet and smoking among Western populations. In contrast, it has recently been shown that among the Singaporese there is limited HAA exposure through diet, while exposure to the HAA carcinogen 2-amino-9H-pyrido[2,3-b]indole (AαC) through cigarette smoking remains high. Using this unique population with relatively simple HAA exposure we have assessed GST modification of smoking related colorectal cancer. There was a significant dose-response relationship between cigarette smoking and colorectal carcinoma among those with an at-risk GST profile (p for trend
Annals Consult Guys - Mythbuster: Preoperative Blood Pressure Control
Authors: Geno J. Merli, Howard H. Weitz
Journal: Annals of Internal Medicine (2017)

Web ExclusivesOctober 17, 2017Annals Consult Guys - Mythbuster: Preoperative Blood Pressure ControlFREEhas associated examAnnals Consult Guys - Mythbuster: Preoperative Blood Pressure ControlFREEGeno J. Merli, MD, Howard H. Weitz, MDGeno J. Merli, MDThomas Jefferson University; Philadelphia, Pennsylvania (G.J.M., H.H.W.)Search for more papers by this author, Howard H. Weitz, MDThomas Jefferson University; Philadelphia, Pennsylvania (G.J.M., H.H.W.)Search for more papers by this authorAuthor, Article and Disclosure Informationhttps://doi.org/10.7326/W17-0010 SectionsSupplemental MaterialAboutVisual AbstractAbstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Annals Consult Guys brings a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations. They address medically relevant topics—whether they be poignant, thought-provoking, or just plain entertaining.For more videos from and information on Annals Consult Guys, visit go.annals.org/ConsultGuys. Comments0 CommentsSign In to Submit A Comment Author, Article and Disclosure InformationDisclosures: Geno J. Merli, MD, reports the following: Research grants/contracts: Bristol-Myers Squibb, Janssen, Portola; Consultancies: Bristol-Myers Squibb, Janssen. Howard H. Weitz, MD, reports that he has no financial relationships or interests to disclose. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics October 17, 2017Volume 167, Issue 8Page: CG1KeywordsBlood pressure ePublished: 17 October 2017 Issue Published: October 17, 2017 CopyrightCopyright © 2017 by American College of Physicians. All Rights Reserved.Loading ...
Is There Merit in Merit Aid?
Authors: Roy C. Ziegelstein, Charles G. Prober, Lloyd B. Minor, George Q. Daley, Paul B. Rothman, Edward M. Hundert
Journal: New England Journal of Medicine (2017)

Interview with Dr. Roy Ziegelstein on the increasing concentration of medical-school debt among fewer students. (08:47)Download There is broad agreement that something must be done to address medical students' increasing educational debt. An important question is whether merit scholarships are part of the solution or part of the problem.
Elevated blood pressure and risk of mitral regurgitation: A longitudinal cohort study of 5.5 million United Kingdom adults
Authors: Kazem Rahimi, Hamid Mohseni, Catherine M. Otto, Nathalie Conrad, Jenny Tran, Milad Nazarzadeh, Mark Woodward, Terence Dwyer, Stephen MacMahon
Journal: PLoS Medicine (2017)

Background Mitral regurgitation in people without prior cardiac disease is considered a degenerative disease with no established risk factors for its prevention. We aimed to test the hypothesis that elevated systolic blood pressure (SBP) across its usual spectrum is associated with higher risk of mitral regurgitation. Methods and findings We used linked electronic health records from the United Kingdom Clinical Practice Research Datalink (CPRD) from 1 January 1990 to 31 December 2015. CPRD covers approximately 7% of the current UK population and is broadly representative of the population by age, sex, and ethnicity. About 5.5 million UK patients with no known cardiovascular or valve disease at baseline were included in this cohort study. We investigated the relationship between blood pressure (BP) and risk of mitral regurgitation using Cox regression models. Our primary exposure variable was SBP and our primary outcome was incident reports of mitral regurgitation, which were identified from hospital discharge reports or primary care records. Of the 5,553,984 patients in the CPRD that met our inclusion criteria, during the 10-year follow-up period, 28,655 (0.52%) were diagnosed with mitral regurgitation and a further 1,262 (0.02%) were diagnosed with mitral stenosis. SBP was continuously related to the risk of mitral regurgitation with no evidence of a nadir down to 115 mmHg (p < 0.001). Each 20 mmHg increment in SBP was associated with a 26% higher risk of mitral regurgitation (hazard ratio [HR] 1.26; CI 1.23, 1.29). The observed association was partially mediated by diseases affecting the left ventricle during follow-up (myocardial infarction [MI], ischaemic heart disease [IHD], cardiomyopathy, and heart failure). However, the percentage of excess risk mediated (PERM) by these proximate causes of secondary mitral regurgitation was only 13% (CI 6.1%, 20%), and accounting for them had little effect on the long-term association between SBP and mitral regurgitation (mediator-adjusted HR 1.22; CI 1.20, 1.25; p < 0.001). Associations were similar for each 10 mmHg increment in diastolic blood pressure (DBP) (p < 0.001) or each 15 mmHg increment in pulse pressure (PP) (p < 0.001). By contrast, there was no association between SBP and risk of mitral stenosis (HR per 20 mmHg higher SBP 1.03; CI 0.93, 1.14; p = 0.58). These analyses are based on routinely collected data from health records which may be sensitive to measurement errors, and the observed associations may not be generalizable to less severe and subclinical cases of mitral regurgitation. Conclusions Long-term exposure to elevated BP across its whole spectrum is associated with an increased risk of primary and secondary mitral regurgitation. These findings suggest that BP control may be of importance in the prevention of mitral regurgitation.
Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation
Authors: Qin Wang, Michael V. Holmes, George Davey Smith, Mika Ala-Korpela
Journal: Diabetes Care (2017)

OBJECTIVE Insulin resistance has deleterious effects on cardiometabolic disease. We used Mendelian randomization analyses to clarify the causal relationships of insulin resistance (IR) on circulating blood-based metabolites to shed light on potential mediators of the IR to cardiometabolic disease relationship. RESEARCH DESIGN AND METHODS We used 53 single nucleotide polymorphisms associated with IR from a recent genome-wide association study (GWAS) to explore their effects on circulating lipids and metabolites. We used published summary-level data from two GWASs of European individuals; data on the exposure (IR) were obtained from meta-GWASs of 188,577 individuals, and data on the outcomes (58 metabolic measures assessed by nuclear magnetic resonance) were taken from a GWAS of 24,925 individuals. RESULTS One-SD genetically elevated IR (equivalent to 55% higher geometric mean of fasting insulin, 0.89 mmol/L higher triglycerides, and 0.46 mmol/L lower HDL cholesterol) was associated with higher concentrations of all branched-chain amino acids (BCAAs)—isoleucine (0.56 SD; 95% CI 0.43, 0.70), leucine (0.42 SD; 95% CI 0.28, 0.55), and valine (0.26 SD; 95% CI 0.12, 0.39)—as well as with higher glycoprotein acetyls (an inflammation marker) (0.47 SD; 95% CI 0.32, 0.62) (P &amp;lt; 0.0003 for each). Results were broadly consistent when using multiple sensitivity analyses to account for potential genetic pleiotropy. CONCLUSIONS We provide robust evidence that IR causally affects each individual BCAA and inflammation. Taken together with existing studies, this implies that BCAA metabolism lies on a causal pathway from adiposity and IR to type 2 diabetes.
TCT-582 30-Day Readmission and Cost-effectiveness of Percutaneous Mitral Valve Repair in the United States, 2011-2014
Authors: Afnan Tariq, Aditya Mantha, Yen-Yi Juo, Laith Mukdad, Ramin Ebrahimi, Peyman Benharash
Journal: Journal of the American College of Cardiology (2017)