tbuckley/cabot-search huggingface dataset:
P3.01-032 Preliminary study of Lung Cancer Adenocarcinoma with De-novo EGFR T790M Mutation in Persahabatan Hospital-Jakarta, Indonesia.
Authors: H. Dewanti, J. Zaini, S. Andarini, E. Syahruddin, A. Putra, A. Hudoyo
Journal: Journal of Thoracic Oncology (2017)
Abstract P126: Physical Activity, Family History of Premature Coronary Heart Disease, and Incident Atherosclerotic Cardiovascular Disease in the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Roberta Florido, Di Zhao, Chiadi E Ndumele, Pamela L Lutsey, John W McEvoy, Beverly G Windham, James S Pankow, Eliseo Guallar, Erin D Michos
Journal: Circulation (2016)

Background: Family history (FHx) of coronary heart disease (CHD) is a well-established risk factor for incident atherosclerotic cardiovascular disease (ASCVD). Certain interventions (e.g. smoking cessation) may be more effective in those with a FH of CHD. Physical activity (PA) is associated with reduced risk of ASCVD. Whether this association varies by FHx of premature CHD is not well established. Methods: We evaluated 9,996 ARIC participants free of ASCVD, and with data on FHx of CHD or PA at Visit 1 (1987-1989). FHx of premature CHD was defined as CHD occurring in a father before the age 55 or in a mother before age 60, as reported by each participant. PA was assessed using a modified Baecke questionnaire, subsequently converted into min/wk of moderate or vigorous exercise. PA was categorized as per AHA guidelines as recommended, intermediate, or poor (see footnote to Table ). Incident ASCVD was defined as incident myocardial infarction, fatal CHD, or stroke. Multivariable adjusted Cox proportional hazard models were used. Results: The mean age was 54±6 years, 56% were women and 21% of black race. Participants with FHx of premature CHD had more adverse lipid profiles but otherwise similar ASCVD risk factors. Participants with and without a FHx of premature CHD reported similar levels of PA at baseline (409 vs 423 MET/min/week, respectively, p=0.85), and approximately 40% of both groups met AHA recommended PA levels. Over a mean follow-up of 20.9 years, there were 1,723 incident ASCVD events. Compared with poor, recommended levels of PA were associated with a significantly lower risk of incident ASCVD ( Table ) without a significant interaction by FHx status (p-interaction=0.68). Conclusion: Despite their FHx and their more adverse lipid profiles, individuals with a FHx of premature CHD had similar PA patterns as compared to those without a FHx, with less than half meeting AHA recommended levels. PA was similarly beneficial against incident ASCVD for both groups. Promotion of PA should be encouraged for all regardless of FHx status.
A notificação electrónica melhora a opportunidade e a exhaustividade da declaração das doenças infecciosas, Holanda, 2003
Authors: M Ward, P Brandsema, E van Straten, A Bosman
Journal: Eurosurveillance (2005)

Em 2002, na Holanda o sistema de notificacao OSIRIS, em linha, via Internet, substituiu-se totalmente ao sistema basado em formularios impresos. Os objectivos de OSIRIS eram de melhorar a opportunidade e a exhaustividade dos dados de vigilância das doencas infecciosas declaradas pelas autoridades regionais ao nivel nacional. Comparamos os prazos na declaracao de 2001 com o sistema convencional com aqueles de OSIRIS em 2003. Tem-se comparado dois tipos de prazo : o prazo total, definido como o tempo passado entre o inicio de sintomas e a declaracao ao nivel nacional; e o prazo central definido como o tempo transcorrido entre o inicio dos sintomas e a declaracao regional e nacional. Os valores medianos para cada sistema foram comparados com o teste de Wilcoxon Rank. Tambem foram comparadas as declaracoes electronicas recebidas por OSIRIS em 2003 com as declaracoes de 2001 do sistema anterior tomando em conta a exhaustividade dos campos de dados especificos. Determinou-se a significacao estatistica das proporcoes dos campos completados em cada sistema com o teste exacto de Fischer e o teste de Mantel-Haenzel com a correccao de Yates. Os resultados mostraram que o prazo central mediano entre o sistema convencional e o sistema OSIRIS tinha-se reduzido significativamente para todas as doencas, passando respeitivamente de 10 dias (interquartile range 4) em 2001 a um dia (interquartile range 1) em 2003. A excepcao dos casos de malaria, o prazo total desde a apparicao dos primeiros sintomas ate a declaracao nacional, tambem tinha reduzido de forma significativa. Alem disso, as declaracoes OSIRIS continham informacoes mais completas que as tradicionais. Ao total, em 2003, 92,3% dos campos de dados estudiados estavam preenchidos, comparado com 81,3% em 2001. Este relatorio confirma as vantagens da declaracao electronica de dados de vigilância das doencas infecciosas concernando os prazos e a exhaustividade.
NCOG-10. FACTORS INFLUENCING NEUROCOGNITIVE FUNCTION IN PATIENTS WITH NEUROEPITHELIAL TUMORS
Authors: Jens Gempt, Nicole Hofmann, Stefanie Bette, Sarah Foreman, Jasmin Hernandez Cammardella, Jennifer Albertshauser, Corinna Gradtke, Niels Buchmann, Yu-Mi Ryang, Friederike Schmidt-Graf, Bernhard Meyer, Florian Ringel
Journal: Neuro-Oncology (2017)

Though cognitive function is proven to be an independent predictor of survival in patients with intrinsic brain tumors, higher cognitive functions are still seldom studied. Aim of this study was to assess neurocognitive function and to identify risk factors for neurocognitive deficits in patients with intrinsic brain tumors. 103 patients with primary neuroepithelial tumors who received tumor resections or biopsies were included in this prospective study. The following data was acquired: mini-mental state examination, preoperative tumor volume, WHO grade, tumor entity and location, and the Karnofsky performance status scale. Furthermore, patients conducted an extensive neuropsychological testing battery of attentional, memory and executive functions. Regarding the results, general factors like age, clinical status, WHO grade, tumor volume and tumor location displayed a correlation with patients’ neurocognitive functions. Affection of the parietal lobe resulted in significant impairment of attention and memory functions. Frontal lobe involvement significantly affected patients’ abilities in planning complex actions and novel problem solving. Patients with temporal lesions were more likely to have impaired memory and executive functions. Comparing results among neuroepithelial tumor patients enables the identification of risk factors for cognitive impairment. General parameters such as age, KPS score, tumor size, and WHO grade are apart from the respective tumor location of high importance for patients neurocognitive function.
Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents in the Mediterranean Region of Europe
Authors: Elena Scarpato, Sanja Kolacek, Danijela Jojkic-Pavkov, Vlatka Konjik, Nataša Živković, Enriqueta Roman, Aco Kostovski, Nikolina Zdraveska, Eyad Altamimi, Alexandra Papadopoulou, Thomai Karagiozoglou-Lampoudi, Raanan Shamir, Michal Rozenfeld Bar Lev, Aziz Koleilat, Sirin Mneimneh, Dario Bruzzese, Rosaura Leis, Annamaria Staiano, Panayota Kafritsa, Sandra Brusa, Angelo Campanozzi, Claudio Romano, Silvia Salvatore, Evelina Kotzakioulafi, Josefa Barrio, Maria Luz Cilleruelo, Mercedes Juste, Carolina Gutiérrez-Junquera, Tena Trbojević, Lana Ivković
Journal: Clinical Gastroenterology and Hepatology (2017)
P2.15-008 Genomic Analysis to Assess a Molecular Signature in Japanese Patients with Pulmonary High Grade Neuroendocrine Carcinoma
Authors: H. Kojima, M. Serizawa, S. Takahashi, M. Isaka, A. Ono, T. Nagashima, S. Ohnami, K. Ohshima, K. Urakami, M. Kusuhara, T. Sugino, T. Takahashi, K. Yamaguchi, Y. Ohde
Journal: Journal of Thoracic Oncology (2017)
Primary tumor site (pTS) as a key factor in adjuvant treatment decision in resected N+ colorectal cancer patients
Authors: R. Giampieri, A. Lanese, G. Pusole, M. Del Prete, A. Bittoni, L. Cantini, E. Maccaroni, V. Pusceddu, S. Delprete, M. Caramanti, T. Meletani, M.G. Baleani, M. Di Pietro Paolo, M. Scartozzi, R. Berardi
Journal: Annals of Oncology (2017)
Surto de doença dos legionários entre os visitantes de uma feira na Bélgica, em 1999
Authors: K De Schrijver, E van Bouwel, L Mortelmans, P van Rossom, T De Beukelaer, C Vael, K Dirven, H Goossens, M Leven, O Ronveaux
Journal: Eurosurveillance (2000)

Em Novembro de 1999, foram identificados, na Belgica, noventa e tres casos de doenca dos legionarios (43 confirmados, 12 presumiveis e 38 possiveis/clinicos) num surto associado a uma feira comercial em Kapellen, Belgica. Faleceram cinco pessoas. A investigacao epidemiologica demonstrou que o periodo de tempo passado na feira e a exposicao a areas particulares da tenda estiveram associados a doenca. Os testes da reaccao em cadeia da polimerase (PCR) demonstraram que uma hidromassagem e uma fonte estavam contaminados com legionela.
Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease
Authors: Kristen L. Nowak, Zhiying You, Berenice Gitomer, Godela Brosnahan, Vicente E. Torres, Arlene B. Chapman, Ronald D. Perrone, Theodore I. Steinman, Kaleab Z. Abebe, Frederic F. Rahbari-Oskoui, Alan S.L. Yu, Peter C. Harris, Kyongtae T. Bae, Marie Hogan, Dana Miskulin, Michel Chonchol
Journal: Journal of the American Society of Nephrology (2017)

The association of overweight/obesity with disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD) remains untested. We hypothesized that overweight/obesity associates with faster progression in early-stage ADPKD. Overall, 441 nondiabetic participants with ADPKD and an eGFR>60 ml/min per 1.73 m2 who participated in the Halt Progression of Polycystic Kidney Disease Study A were categorized on the basis of body mass index (BMI; calculated using nonkidney and nonliver weight) as normal weight (18.5-24.9 kg/m2; reference; n=192), overweight (25.0-29.9 kg/m2; n=168), or obese (≥30 kg/m2; n=81). We evaluated the longitudinal (5-year) association of overweight/obesity with change in total kidney volume (TKV) by magnetic resonance imaging using linear regression and multinomial logistic regression models. Among participants, mean±SD age was 37±8 years, annual percent change in TKV was 7.4%±5.1%, and BMI was 26.3±4.9 kg/m2 The annual percent change in TKV increased with increasing BMI category (normal weight: 6.1%±4.7%, overweight: 7.9%±4.8%, obese: 9.4%±6.2%; P<0.001). In the fully adjusted model, higher BMI associated with greater annual percent change in TKV (β=0.79; 95% confidence interval [95% CI], 0.18 to 1.39, per 5-unit increase in BMI). Overweight and obesity associated with increased odds of annual percent change in TKV ≥7% compared with <5% (overweight: odds ratio, 2.02; 95% CI, 1.15 to 3.56; obese: odds ratio, 3.76; 95% CI, 1.81 to 7.80). Obesity also independently associated with greater eGFR decline (slope) versus normal weight (fully adjusted β =-0.08; 95% CI, -0.15 to -0.02). In conclusion, overweight and, particularly, obesity are strongly and independently associated with rate of progression in early-stage ADPKD.
ATIM-14. ALLIANCE A071101: A PHASE II RANDOMIZED TRIAL COMPARING THE EFFICACY OF HEAT SHOCK PROTEIN PEPTIDE COMPLEX-96 (HSPPC-96) VACCINE GIVEN WITH BEVACIZUMAB VERSUS BEVACIZUMAB ALONE IN THE TREATMENT OF SURGICALLY RESECTABLE RECURRENT GLIOBLASTOMA
Authors: Orin Bloch, Qian Shi, S Keith Anderson, Michael Knopp, Jeffrey Raizer, Jennifer Clarke, Allen Waziri, Howard Colman, Jeffrey Bruce, Jeffrey J Olson, John Schwerkoske, Andrew Parsa, Joon Uhm, Priya Kumthekar, Evanthia Galanis, Ian Parney
Journal: Neuro-Oncology (2017)

Heat shock protein vaccines can be used to stimulate anti-tumor immune responses. An autologous vaccine (HSPPC-96) generated from patient resected tumors has been previously studied in single arm phase I/II trials for newly diagnosed and recurrent GBM. Based on promising survival in these studies, a randomized, multi-centered phase II trial of HSPPC-96 for recurrent GBM compared to bevacizumab was undertaken (NCT01814813). Patients with 1st/2nd recurrence of resectable GBM were enrolled and underwent surgery with generation of HSPPC-96 from autologous tumors. Post-operative eligibility included a volumetric extent of resection ≥90% (by central review) and sufficient tumor to generate a minimum of 4 vaccine doses. Patients were randomized (1:1:1) to receive HSPPC-96 vaccine followed by bevacizumab at subsequent progression vs. concurrent HSPPC-96 vaccine and bevacizumab vs. bevacizumab alone. The primary endpoint was overall survival (OS) aiming to detect a 36% reduction in HR with 85% power and alpha=0.1 for pooled HSPPC-96 groups vs. bevacizumab alone. Planned enrollment was 165 patients (n=55/arm). An interim analysis was pre-planned at 50% of events (65 deaths). Secondary endpoints included progression-free survival and adverse events. At final analysis, 90 patients were enrolled with a distribution of 29:30:31. The study was terminated for futility after the interim analysis. In the intention to treat population, OS for the HSPPC-96 treated groups was 7.5 vs. 10.7 months for bevacizumab alone (HR=2.06 [95% CI 1.18–3.60], p=0.008). Among patients treated per protocol (n=73), OS for HSPPC-96 patients was 8.6 vs. 12.3 months (HR=1.99 [95% CI 1.03–3.81], p=0.03). Trends were similar for progression-free survival between groups. HSPPC-96 toxicity was well tolerated with no attributable serious adverse events. The study failed to demonstrate a survival benefit for patients treated with HSPPC-96 alone or in combination with bevacizumab compared to bevacizumab alone. Correlative analyses are ongoing. SUPPORT: U10CA180882, U10CA180821, U10CA180868, U24CA196171.
P3.13-003 The Lung Cancer Prognostic Index – a Risk Score to Predict Overall Survival after the Diagnosis of Non-Small Cell Lung Cancer
Authors: M. Alexander, R. Wolfe, D. Ball, M. Conron, R. Stirling, B. Solomon, M. Macmanus, A. Officer, S. Karnam, K. Burbury, S. Evans
Journal: Journal of Thoracic Oncology (2017)
PDCT-19. A SAFETY STUDY OF VEMURAFENIB, AN ORAL INHIBITOR OF BRAFV600E, IN CHILDREN WITH RECURRENT/REFRACTORY BRAFV600E MUTANT BRAIN TUMORS: PNOC-002
Authors: Theo Nicolaides, Kellie Nazemi, John Crawford, Lindsay Kilburn, Jane Minturn, Amar Gajjar, Karen Gauvain, Sarah Leary, Girish Dhall, Mariam Aboian, Giles Robinson, Annette Molinaro, Sabine Mueller, Michael Prados
Journal: Neuro-Oncology (2017)

BACKGROUNDVemurafenib is an orally available, selective ATP-competitive inhibitor of BRAF-V600E kinase, approved in adult metastatic melanoma patients with the V600E mutation. This study was designed to determine the recommended phase 2 dose (RP2D) in patients < 18yrs with BRAF-V600E mutant brain tumors.
Contrast ultrasound LI-RADS LR-5 identifies hepatocellular carcinoma in cirrhosis in a multicenter restropective study of 1,006 nodules
Authors: Eleonora Terzi, Massimo Iavarone, Maurizio Pompili, Letizia Veronese, Giuseppe Cabibbo, Mirella Fraquelli, Laura Riccardi, Ludovico De Bonis, Angelo Sangiovanni, Simona Leoni, Maria Assunta Zocco, Sandro Rossi, Nicola Alessi, Stephanie R. Wilson, Fabio Piscaglia, Alessandro Granito, Veronica Salvatore, Francesco Tovoli, Matteo Angelo Manini, Gian Lodovico Rapaccini, Maria Elena Ainora, Valentina Ravetta, Giorgia Ghittoni, Agostino Ventra, Giuseppe Mogavero
Journal: Journal of Hepatology (2017)
P3.09-010 18 Years Single Center Experience of Surgical Resection of Malignant Pleural Mesothelioma After Induction Chemotherapy
Authors: O. Lauk, M. Friess, M. Kirschner, M. Meerang, V. Orlowski, W. Weder, I. Inci, I. Opitz
Journal: Journal of Thoracic Oncology (2017)
P3.06-003 What Do the Children Think about Smoking and How Are They Helped in Prevention?
Authors: D. Bafunno, D. Galetta, C. Biglia, A. Catino, F. Ferraresi, V. Lapadula, S. Leo, A.F. Logroscino, A. Miccianza, A. Misino, E.S. Montagna, M.V. Pacchiana, P. Petrillo, P. Pizzutilo, S.G. Rapetti, D. Ricci, S. Novello
Journal: Journal of Thoracic Oncology (2017)
La surveillance internationale de la résistance aux antibiotiques en Europe : l’heure est à la surveillance de l’utilisation des antibiotiques
Authors: S L A M Bronzwaer, U Buchholz, J. L. Kool
Journal: Eurosurveillance (2001)

Le risque de dissemination des agents pathogenes (resistants) s’accroit avec l’augmentation des voyages et des echanges commerciaux dans l’Union Europeenne (UE) au fil des annees. De nombreuses etudes ont montre que la resistance aux antibiotiques devient un probleme toujours plus important. Les Staphylococcus aureus que l’on trouvait essentiellement dans les hopitaux concernent actuellement de plus en plus les infections communautaires ; de meme, la dissemination de certaines souches entre des pays d’Europe a ete demontree (1). La resistance aux antibiotiques peut etre a l’origine d’hospitalisations prolongees, d’un surcout, d’un accroissement de la morbidite voire de la mortalite (2).
Monocyte DPP4 Expression in Human Atherosclerosis Is Associated With Obesity and Dyslipidemia
Authors: Xiaoquan Rao, Jeffrey A. Deiuliis, Georgeta Mihai, Juliet Varghese, Chang Xia, Matthew B. Frieman, Carole Sztalryd, Xiao Jian Sun, Michael J. Quon, Simeon I. Taylor, Sanjay Rajagopalan, Jixin Zhong
Journal: Diabetes Care (2017)

Studies including ours indicate that systemic inhibition of dipeptidyl peptidase 4 (DPP4), an ubiquitously expressed peptidase, by pharmaceutical inhibitors improved atherosclerosis (1,2). However, the role of immune cell–derived DPP4 is not well defined in atherosclerosis. Our previous work demonstrated that DPP4 expression on monocytes/macrophages was increased in obesity and associated with the degree of insulin resistance (3). To test if the obesity-related increase of monocyte DPP4 plays a role in vascular disease, we investigated the relationship of monocyte DPP4 expression with human aortic atherosclerosis, obesity, and lipid metabolism. A total of 14 control volunteers and 27 atherosclerotic patients without diagnosed heart, lung, or liver diseases and without prescription drugs (except ACE inhibitors and angiotensin receptor blockers) were selected from Aliskiren Effect on Aortic Plaque Progression (ALPINE), a phase 4 clinical trial (clinical trial reg. no. NCT01417104, clinicaltrials.gov). Presence of aortic atherosclerotic plaque (Fig. 1 A ) was confirmed by high-resolution three-dimensional MRI.



Figure 1 
A : High-resolution three-dimensional dark-blood MRI was used to confirm the aortic atherosclerotic plaque in patients with atherosclerotic disease. Arrows indicate the thickening of the aortic wall. Scale bars, 10 mm. B and C : DPP4 expression on circulating immune cells. Peripheral blood mononuclear cells were isolated from healthy volunteers, and CD11b+ monocyte and CD3+ T cells were gated for …
Persistence of Penicillin Allergy
Authors: Vito Sabato, Margo Hagedorens, Didier Ebo
Journal: JAMA (2017)

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Surgical registrar is struck off for refusing to examine three deteriorating patients
Authors: Clare Dyer
Journal: BMJ (2017)

A surgical registrar who repeatedly refused appeals from junior doctors to attend and examine three deteriorating patients has been struck off by a medical practitioners tribunal in Manchester.

Abayomi Sanusi, who did not attend his hearing, was also found to have lied in a job interview after being dismissed by South Tees NHS Foundation Trust for his clinical failings in three cases at Friarage Hospital in Northallerton, North Yorkshire.

Sanusi was found to have been rude and aggressive to junior doctors and senior nurses who called him asking for help. He failed to examine sick and deteriorating patients when he had a clear duty to do so as the doctor on call, and he did not keep proper …
La epidemiología de la sífilis infecciosa en la Republica de Irlanda
Authors: M Cronin, L Domegan, L Thornton, M Fitzgerald, S Hopkins, P O’Lorcain, E Creamer, D O'Flanagan
Journal: Eurosurveillance (2004)

En respuesta al numero creciente de casos de sifilis en hombres que tienen relaciones sexuales con otros hombres (HRSH) en Dublin, se constituyo a finales de 2000 un grupo de control de los brotes (Outbreak Control Team, OCT). La epidemia alcanzo su maximo en 2001 y termino a finales de 2003. Para recoger los datos desde enero de 2000 se puso en marcha un sistema reforzado para la vigilancia de la sifilis. 
Entre Enero 2000 y Diciembre 2003, se declararon en Irlanda 547 casos de sifilis infecciosa (de los cuales 415 eran HRSH). Durante los tres meses precedentes, el 4% de los casos fueron infectados por el VIH y 15,4% por al menos una infeccion de transmision sexual (ITS) (excluyendo el VIH). El numero medio de relaciones declaradas por los casos varones en los tres meses anteriores al diagnostico era cuatro (entre 0 y 8) para las relaciones heterosexuales y seis para las relaciones homosexuales (entre 1 y 90). El 31% de los HRSH declararon relaciones sexuales orales sin proteccion recientes y el 15,9% relaciones anales sin proteccion. El 16% habian tenido relaciones sexuales en el extranjero en los tres meses previos al diagnostico. Los resultados sugieren que las practicas sexuales de riesgo contribuyeron a la transmision de la infeccion en Dublin. La epidemia de Dublin puede ser considerada como parte de una epidemia de sifilis al nivel europeo. Las tasas de co-infeccion por el VIH y la sifilis en Irlanda son comparables a las declaradas por otros centros. Es necesario mejorar los sistemas de vigilancia para poder evaluar las intervenciones en tiempo real y monitorizar de forma continuada la tendencia de la infeccion.