tbuckley/cabot-search huggingface dataset:
Tratamiento de las perforaciones post-CPRE: Quirúrgico vs endoscópico
Authors: V Calabuig Mazzola, A Alvarez Delgado, A Jimenez Jurado, H Marcos Prieto, M García Prada, A Gonzalez Cotorruelo, A Marcos Martin, P Rodríguez Lopez, A Rodríguez Perez
Journal: Endoscopy (2017)

La perforación es una complicación grave de la colangiopancreatografía retrógrada endoscópica (CPRE). La incidencia de las mismas es del 0,8 al 1,6%. Actualmente no existe un consenso para su tratamiento, aunque predomina el quirúrgico.
The importance of red cell distribution width on gastric cancer.
Authors: Dilek Erdem, Emre Erdem, Yasemin Turgut Kurt, Turkan Topcu, Turgut Kacan, Meral Gunaldi, Bahiddin Yilmaz
Journal: Journal of Clinical Oncology (2017)

e15502 Background: Red cell distribution width (RDW) is an elevated marker in several cancers like breast, colon, prostate and pancreatic cancer at the time of diagnosis. Gastric cancer (GC) is the fifth most common cancer and also third leading cause of cancer deaths.We aimed to determine whether RDW values differ between gastric cancer and healthy subjects, as well as to evaluate association between RDW and other factors. Also, we examined other two important inflammatory markers in GC patients: neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) Methods: This retrospective study included 68 gastric cancer patients and 42 age and sex matched healthy controls. The exclusion criteria involved cardiac disease, chronic obstructive lung disease, thromboembolism, chronic renal failure, hepatic disorders, hypertension, acute and chronic infections, stroke, hematologic disease and other accompanying cancer. Blood samples were retrospectively obtained from computerized patient database. Results: Among 110 subjects; RDW, NLR and PLR were significantly higher in GC patients when compared to healthy subjects (RDW: 44,9 vs 41,4 p &lt; 0.0001, NLR: 3,40 vs 1,90 p &lt; 0.0001, PLR: 245,9 vs 131,1 p = 0.007). There was no statistically significant association between these markers (RDW, NLR and PLR) and stage, histopathological subgroups and metastasis stage at the time of diagnosis. Conclusions: Elevated RDW is a simple, cheap and readily available marker and may be useful in gastric cancer at the time of diagnosis. Also, NLR and PLR can accompany RDW in the assessment of gastric cancer. Key words: gastric, red cell distribution width, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, cancer
Abstract 205: Feasibility and Testing of a Human Induced Pluripotent Stem Cell Derived Cardiac Patch in a Pre-clinical Swine Model of CHF
Authors: Jordan J Lancaster, Ike Chinyere, Bin Na Kim, Sherry Daugherty, Samuel Kim, Clint Jokerst, Ryan Avery, Brandon Larson, Laryenth D Lancaster, Elizabeth Juneman, Steven Goldman
Journal: Circulation Research (2016)

Introduction: Previously we have demonstrated that a tissue engineered heart patch comprised of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) and fibroblasts improves both left ventricular (LV) systolic and diastolic function in a rat model of CHF. In this study we tested the feasibility of upscaling cardiac patch size and surgical deployment in a swine model of CHF to test clinical utility. Methods: Four male Gottingen mini swine 20-25kg and three domestic swine 50-60kg were infarcted using percutaneous methods. Embolizing coils were deployed via catheter distal to the first diagonal branch of the left anterior descending (LAD) coronary artery and animals recovered for 4 weeks. Cardiac patches engineered with bio absorbable polygalactin-910 knitted mesh, dermal fibroblasts and hiPSC-CMs were cultured and implanted on the infarcted epicardium 4 weeks after MI. Cardiac magnetic resonance imaging was performed at baseline, 4 and 8 weeks post MI. All swine were implanted with continuous event recorders to acquire surface electrocardiogram during the entire study. In addition quality of life and functional capacity were assessed through video monitoring and treadmill exertion testing respectively. Infarct size was determined through 2,3,5-triphenyltetrazolium chloride staining. Results: LAD occlusion resulted in a significant (P&lt;0.05) decrease EF (15%), and increase in EDV (59%) and ESV (100%). Average TIMI score decreased from 3.0±0 at time of MI to 1.5±0.6 4wks post MI. Cardiac patches were upsized to 6cm diameter for application in the swine. Patches displayed synchronous and spontaneous contractions within 48hrs. The 6cm patches, when implanted effectively covered the infarcted region bridging viable myocardium. Surgical handling and epicardial deployment was successfully accomplished via median sternotomy. The patches were robust in nature and could be deployed via a minimally invasive robotic procedure. No adverse arrhythmic activity was observed. Implantation of the cardiac patch restored activity levels (quality of life) of patch treated swine vs CHF controls. Conclusion: Our hiPSC-CM cardiac patch can be constructed in a clinical size, easily handled and implanted on the epicardium of the infarcted heart.
Епідеміологічні особливості хвороб органів травлення в дітей та підлітків в Україні
Authors: I.Yu. Skirda, O.P. Petishko, N.Yu. Zavgorodnyaya
Journal: GASTROENTEROLOGY (2017)

Актуальність. Питання ранньої діагностики, лікування та профілактики хвороб органів травлення в дітей останніми роками вийшли за рамки власне педіатрії та становлять собою складну і велику медико-соціальну проблему. Тому метою дослідження було проведення аналізу поширеності та захворюваності на хвороби органів травлення серед дитячого населення України протягом 4 останніх років (2013–2016 рр.). Матеріали та методи. Аналіз проводили за офіційними звітними даними, що подаються до Центру медичної статистики МОЗ України в 25 регіонах. Результати. Незважаючи на те, що зміна динамічного ряду поширеності та захворюваності на хвороби органів травлення має тенденцію до зниження, гастроентерологічна патологія посідає 2-ге місце в структурі поширеності та 4-те місце в структурі захворюваності за класами хвороб серед дітей та підлітків. Статевий розподіл дозволив виявити переважання дівчат серед хворих на захворювання органів травлення. Висновки. Установлені регіональні аспекти поширеності та захворюваності на гастроентерологічні захворювання в дітей та підлітків: найвищий рівень поширеності зареєстрований у м. Києві, Полтавській, Чернігівській та Рівненській областях, а найнижчий — у Запорізькій, Луганській та Одеській областях; найвищі значення захворюваності спостерігали в Івано-Франківській, Рівненській та Чернівецькій, а найнижчі — в Одеській, Запорізькій, Луганській, Донецькій та Херсонській областях.
Is Medical Education a Public or a Private Good?
Authors: Catherine R. Lucey
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CMS Vows to Overhaul Medicaid
Authors: Bridget Kuehn
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer
Authors: Qian Liang, Dan Ma, Xiaoqiang Zhu, Zhenhua Wang, Tian-Tian Sun, Chaoqin Shen, Tingting Yan, Xianglong Tian, TaChung Yu, Fangfang Guo, JiaYin Tang, Yanwei Lin, Huimin Chen, Chao Zhou, Zhizheng Ge, Ming Zhong, Jinxian Chen, Qiang Liu, Zheng Wang, Jing-Yuan Fang, Haoyan Chen, Jie Hong
Journal: Clinical Cancer Research (2017)

Objective: The E3 ubiquitin ligase RNF6 (RING-finger protein 6) plays a crucial role in carcinogenesis. However, the copy number and expression of RNF6 were rarely reported in colorectal cancer. We aimed to explore the mechanical, biological, and clinical role of RNF6 in colorectal cancer initiation and progression.Design: The copy number and expression of RNF6 were analyzed from Tumorscape and The Cancer Genome Atlas (TCGA) datasets. Gene expressions were examined by real-time PCR, Western blot, and immunohistochemical staining. Gene expression profiling studies were performed to identify pivotal genes regulated by RNF6. Biological function of RNF6 on tumor growth and metastasis was detected in vivo and in vitro Role of RNF6 in modulating SHP-1 expression was examined by coimmunoprecipitation and confocal microscopy, respectively.Results: The copy number of RNF6 was significantly amplified in colorectal cancer, and the amplification was associated with RNF6 expression level. Amplification and overexpression of RNF6 positively correlated with patients with colorectal cancer with poor prognosis. The gene set enrichment analysis (GSEA) revealed cell proliferation, and invasion-related genes were enriched in RNF6 high-expressed colorectal cancer cells as well as in patients from TCGA dataset. Downregulation of RNF6 impaired the colorectal cancer cell proliferation and invasion in vitro and in vivo RNF6 may activate the JAK/STAT3 pathway and increase pSTAT3 levels by inducing the ubiquitination and degradation of SHP-1.Conclusions: Genomic amplification drives RNF6 overexpression in colorectal cancer. RNF6 may be a novel biomarker in colorectal carcinogenesis, and RNF6 may increase pSTAT3 level via promoting SHP-1 ubiquitylation and degradation. Targeting the RNF6/SHP-1/STAT3 axis provides a potential therapeutic option for RNF6-amplified tumors. Clin Cancer Res; 24(6); 1473-85. ©2017 AACR.
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Authors: Alan J Thompson, Brenda L Banwell, Frederik Barkhof, William M Carroll, Timothy Coetzee, Giancarlo Comi, Jorge Correale, Franz Fazekas, Massimo Filippi, Mark S Freedman, Kazuo Fujihara, Steven L Galetta, Hans Peter Hartung, Ludwig Kappos, Fred D Lublin, Ruth Ann Marrie, Aaron E Miller, David H Miller, Xavier Montalban, Ellen M Mowry, Per Soelberg Sorensen, Mar Tintoré, Anthony L Traboulsee, Maria Trojano, Bernard M J Uitdehaag, Sandra Vukusic, Emmanuelle Waubant, Brian G Weinshenker, Stephen C Reingold, Jeffrey A Cohen
Journal: The Lancet Neurology (2017)
EFFECTS OF PULMONARY HEMODYNAMICS ON LUNG FUNCTION IN ADLU PATIENTS WITH ATRIAL SEPTAL DEFECT
Authors: Takao Yoshioka, Takeyoshi Kunieda, Masahiro Naito, Yasuo Fukunaga, Shumpei Okubo, Norifumi Nakanishi
Journal: Circulation (1985)

To clarify the relationship of pulmonary function with differing severity of atrial septal defect (ASD) and to assess the effects of pulmonary hemodynamics on these functions, we classified 101 patients with adult ASD by their pulmonary arterial mean pressure (PAm) and pulmonary blood flow (Qp), and compared details of pulmonary functions between pairs of groups. Classification was by drawing lines at the PAm of 20 mmHg and the Qp of 10 L/min. Group I was the low pressure-low flow group, Group II the low pressure-high flow group, Group III the high pressure-low flow group, and Group IV the high pressure-high flow group. Vital capacity as the percentage of predicted (%VC) was low in Group III and IV. There were no significant differences in the ratio of forced expiratory volume in one second to forced vital capacity (FEVl%), flow at 25% forced vital capacity and colsing volume as the percentage of predicted (%V25, %CV/VC) between each group. Both maximum midexpiratory flow rate and flow rate at 50% forced vital capacity as the percentage of predicted (%MMEF, %V50) in Group III with the most severe ASD, were significantly low. Pulmonary diffusing capacities for carbon monoxide as the percentage of predicted (%DLco) exceeded 100% in all groups, and tended to decrease with increases of PAm without relation to Qp. Pulmonary dysfunctions in adult ASD were mainly due to restrictive changes accompanied by obstructive change in proportion to the decrease of VC. Peripheral airway obstructions are mild in ASD and these might be caused by lower pressure of left atrium and no existence of pulmonary venous congestion in ASD, even in the most severe group.
Triphala, an Ayuervedic Herbal Medicine inhibits in vitro and in vivo growth of pancreatic cancer cells
Authors: Yan Shi, Sanjay Srivastava
Journal: Cancer Research (2007)

LB-142   Triphala (TPL) is one of the most popular Ayurvedic medicines, generally used as an antioxidant as well as for the treatment of various intestinal-related disorders. This herbal drug consists of the dried and powdered fruits of three plants, Terminalia chebula, Emblica officinalis, and Terminalia bellerica in equal proportions. Here we report for the first time the anti-cancer effects of the aqueous extract of TPL on pancreatic cancer cells in vitro and in vivo and further evaluated the molecular mechanisms of TPL-induced apoptosis. TPL suppressed the growth of capan-2 pancreatic cancer cells, but not normal immortal human pancreatic ductal epithelial (HPDE) cells, via induction of apoptosis. TPL-induced apoptosis was associated with elevated reactive oxygen species production. Interestingly, TPL treatment caused phosphorylation of p53 at Ser-15 and ERK at Thr-202/Tyr-204 in capan-2 cells having wild type p53. Pretreatment of cells with pifithrin-α (specific inhibitor of p53) or U0126 (specific MEK/ERK inhibitor), significantly attenuated TPL-induced apoptosis. Similarly, pretreatment of capan-2 cells with N-acetyl cysteine (NAC), a general antioxidant, inhibited TPL-induced apoptosis by inhibiting the phosphorylation of p53 and ERK. Moreover, orally feeding 50mg/kg 5 days/week significantly suppressed the growth of capan-2 pancreatic tumor xenograft in vivo in athymic nude mice, without any toxic effects. Reduced tumor growth in TPL fed mice was due to increased apoptosis in the tumors cells as revealed by TUNEL staining. Taken together, our results strongly suggest that TPL has a potential to be used as novel therapeutic agent for the treatment of pancreatic cancer. [Supported in part by RO1 grant CA 106953 (to S.K.S.) awarded by the National Cancer Institute].
Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment
Authors: Hitisha K. Patel, Teeru Bihani
Journal: Pharmacology & Therapeutics (2017)

Breast cancer is the most frequently diagnosed cancer in women, with estrogen receptor positive (ER+) breast cancer making up approximately 75% of all breast cancers diagnosed. Given the dependence on active ER signaling in these tumors, the predominant treatment strategy has been to inhibit various aspects of this pathway including directly antagonizing ER with the use of selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs). Interestingly, the dependence on ER for breast cancer growth is often retained even after progression through several lines of antiestrogen therapy, making ER a bonafide biomarker for this cancer subtype and driving the continued research and development of novel ER-targeted therapeutics to treat this patient population. This, combined with the continuous discovery of mechanisms underlying endocrine resistance, is resulting in a continually evolving treatment landscape for ER+ breast cancer. This review discusses various ER antagonists investigated for the treatment of breast cancer, outlining their pharmacological and tissue-specific mechanisms of action as well as their specified use within the ER+ breast cancer setting. In addition, mechanisms of resistance to SERMs and SERDs, the use of ER antagonists in combination therapy strategies, and the ongoing development of novel drugs are also reviewed in the context of the changing clinical landscape of ER+ breast cancer. Lastly, the role of SERMs and SERDs in non-breast cancer indications is also discussed.
Comparative studies on the effect of heparins, oral anticoagulant, anti-Xa and anti-IIa drugs on thrombin activatable fibrinolytic inhibitor as measured by a functional assay (Pefakit (R) TAFI). Implications on endogenous fibrinolysis.
Authors: M. Florian-Kujawski, D. Hoppensteadt, J. Maddineni, M. Wilmer, M.H.M. Janssen, J. Fareed
Journal: Blood (2003)
201Tl Myocardial Perfusion Imaging in a Case of Double-Inlet Left Ventricle
Authors: Ming-Che Chang, Meng-Luen Lee, Po-Ta Yang
Journal: Clinical Nuclear Medicine (2017)

Abstract Double-inlet left ventricle (DILV) is a congenital heart disease that only a single left ventricle and a rudimentary right ventricle are developed. Because of lack of anatomic landmark, interpretation of 201 Tl myocardial perfusion imaging in DILV is essentially challenging for unusual anomaly. We report the case of a 44-year-old woman with DILV who presented exertional dyspnea and tachycardia and underwent 201 Tl SPECT. The anatomic characteristics of cardiac 201 Tl SPECT are correlated with MRI. To obtain accurate interpretation in DILV, it is absolutely necessary to realize the anatomy relationship between perfusion imaging and anatomic imaging such as CT or MRI.
How costs get discussed (or not) in routine oncology practice.
Authors: Rahma M. Warsame, Aminah Jatoi, Brittany Kimball, Cara Fernandez, Aaron L Leppin, Ashok Kumbamu, Jon Charles Tilburt
Journal: Journal of Clinical Oncology (2017)

6512 Background: Cancer patients are nearly 3x more likely to declare bankruptcy than people without cancer. However, little is known about the dynamics of the healthcare provider/patient (pt) conversations around cost issues, the range of topics explored, and the factors that may influence them. We reviewed audio recordings of a cross-section of medical oncology conversations to determine frequency, patterns and attitudes of pts and providers on cost. Methods: We audio recorded conversations between 5/3/2012 &amp; 11/20/2013 for adult patients with any solid tumor malignancy seen in an outpatient medical oncology clinic at one of three sites in the Upper Midwest and Southern California. Basic demographic variables were abstracted from chart review. Recordings were de-identified, reviewed and flagged for any mention of cost. We used descriptive statistics and inductive qualitative content coding methods to further characterize conversation themes. Results: Among 525 recordings, 151 (28%) contained any mention of cost. Median age (range) of pts was 58 years (22-93), and 75% Caucasian, 18% Hispanic, 5% Asian, and 1% Black. Average length of cost discussions was &lt; 2 minutes, and pts usually initiated the discussion (106 /151). Among the 151 conversations, social service referrals were mentioned only 6 times (4%). Through qualitative analysis we identified several key topics: insurance coverage, disability, drug copays, and transportation. The recording dynamics most frequently displayed acknowledging but not taking action on the part of clinicians. Only 25% of clinicians behave confidently in how to address a patients cost concerns. Conclusions: In a diverse cross-section of oncology visits, cost comes up only 1/4 to 1/3 of the time and focuses on insurance coverage, disability and out of pocket drug costs. However clinicians often leave these issues unaddressed. Discussing financial burdens and identifying way to improve existing conversations will be important to mitigate additional financial distress. [Table: see text]
Структурна трансформація протокової системи підшлункової залози у хворих на хронічний панкреатит
Authors: Yu.A. Mikheiev, А.V. Yevseiev, А.V. Kanaki
Journal: GASTROENTEROLOGY (2017)

Актуальність. Клітини проток становлять до 30 % від маси підшлункової залози (ПЗ) людини, а збільшення кількості бранчів проток відноситься до одних із перших сонологічних ознак хронічного панкреатиту (ХП). Мета дослідження — визначення морфологічних й імуногістохімічних особливостей протокової системи ПЗ хворих на ХП, яким були виконані резекційні та дренуючі операції з приводу ускладнень хронічного панкреатиту. Матеріали та методи. Проведено імуногістохімічне дослідження операційного матеріалу 40 хворих з ускладненим хронічним панкреатитом з використанням реакцій на a-ізоформу гладком’язового актину (a-SMA), десмін, фібронектин й колаген I типу. Результати. Характерна морфологічна картина розвитку ХП є поєднанням фіброзування з деформацією протокової системи за рахунок перидуктального фіброзу з розширенням міждолькових фіброзних септ, потовщенням інтралобулярних сполучно­тканинних тяжів, а також значною звивістістю і розширенням проток з ретенційними кістами. Значна структурна перебудова протокової системи ПЗ у хворих на ХП спостерігалася в 87,5 % випадків, в 17,5 % випадків картина доповнювалася явищами ацинарно-протокової метаплазії з трансформацією ацинарних клітин у протокові і формуванням дрібних дуктулоподібних структур, так званих тубулярних комплексів. У 7,5 % випадків в головній панкреатичній протоці визначалися вогнища атрофії протокового епітелію, які чергувалися з вогнищами папілярної інтраепітеліальної гіперплазії епітелію (PanIN). Розвитку панкреатичного фіброзу при ХП сприяє накопичення a-SMA+-активованих панкреатичних зірчастих клітин, що синтезують надлишок компонентів екстрацелюлярного матриксу, зокрема колагену I типу. Середня площа колагену І типу та інтенсивність його експресії були вірогідно нижче при зниженій експресії a-SMA (p &lt; 0,05) і вірогідно вище у випадках вираженої експресії фібронектину (p &lt; 0,05). Висновки. Вивчення структурних змін протокової системи ПЗ з використанням методів імуногістохімії є одним із способів покращення ранньої діагностики ускладнень ХП.
Crispr Engineering in CD34+ Progenitors Reveals Cis-Acting Regulatory Regions Mediating 3D Interactions and Stem Cell Fate Decisions
Authors: Mira Jeong, Yong Lei, Ivan Bochkov, Muhammad S Shamim, Anna G Guzman, Su-Chen Huang, Olga Dudchenko, Ido Machol, Michael C Gundry, Huthayfa Mujahed, Soren Lehmann, Erez S Lieberman, Margaret A Goodell
Journal: Blood (2016)