tbuckley/cabot-search huggingface dataset:
Reconstruction of head impacts in FIS World Cup alpine skiing
Authors: Sophie Elspeth Steenstrup, Kam-Ming Mok, Andrew S McIntosh, Roald Bahr, Tron Krosshaug
Journal: British Journal of Sports Medicine (2017)

Prior to the 2013/2014 season, the International Ski Federation (FIS) increased the helmet testing speed from 5.4 to 6.8 m/s for alpine downhill, super-G and giant slalom. Whether this increased testing speed reflects head impact velocities in real head injury situations on snow is unclear. We therefore investigated the injury mechanisms and gross head impact biomechanics in seven real head injury situations among World Cup (WC) alpine skiers.We analysed nine head impacts from seven head injury videos from the FIS Injury Surveillance System, throughout nine WC seasons (2006-2015) in detail. We used commercial video-based motion analysis software to estimate head impact kinematics in two dimensions, including directly preimpact and postimpact, from broadcast video. The sagittal plane angular movement of the head was also measured using angle measurement software.In seven of nine head impacts, the estimated normal to slope preimpact velocity was higher than the current FIS helmet rule of 6.8 m/s (mean 8.1 (±SD 0.6) m/s, range 1.9±0.8 to 12.1±0.4 m/s). The nine head impacts had a mean normal to slope velocity change of 9.3±1.0 m/s, range 5.2±1.1 to 13.5±1.3 m/s. There was a large change in sagittal plane angular velocity (mean 43.3±2.9 rad/s (range 21.2±1.5 to 64.2±3.0 rad/s)) during impact.The estimated normal to slope preimpact velocity was higher than the current FIS helmet rule of 6.8 m/s in seven of nine head impacts.
Etude de la contamination d’aliments d’origine animale par Escherichia coli sérotype O157:H7 producteur de shigatoxines en Belgique de 1999 à 2003
Authors: A Chahed, Y Ghafir, B China, K Dierick, L De Zutter, D Piérard, G Daube
Journal: Eurosurveillance (2005)

Une etude sur la prevalence d’Escherichia coli (STEC) de serotype O157 producteur de shigatoxines provenant de denrees alimentaires d’origine animale (bœuf, veau, porc, poulet, poisson) a ete menee entre 1999 et 2003 en Belgique. Les souches de STEC n’ont ete isolees que dans la viande de bœuf, avec une prevalence de 0,73%. Il s’agit d’une prevalence faible comparee a celle d’autres pays. Parmi les 76 souches de STEC O157 isolees, 75% appartiennent au serotype O157:H7 et 25% au serotype O157 non H7. De plus, le pathotype le plus frequent etait eae stx2 ehxA (74%).
Clonal diversity of MYC amplification evaluated by FISH and digital droplet polymerase chain reaction (ddPCR) in oesophagogastric (OG) cancer
Authors: M. Davidson, H. Bryant, L. Aronson, J. Howard-Reeves, D. Cunningham, N. Starling, D. Watkins, S. Rao, R. Cutts, M. Llorca-Cardenosa, R. Begum, I. Rana, A. Wotherspoon, J. Swansbury, I. Chau, I. Chong
Journal: Annals of Oncology (2017)
Novel malignant bowel obstruction (MBO) management program for women with advanced gynecological cancer.
Authors: Yeh Chen Lee, Nazlin Jivraj, Catherine O'Brien, Jenny Lau, Tanya Chawla, Eran Shlomovitz, Sarah Buchanan, Jennifer Croke, Johane P Allard, Preeti Dhar, Stephane Laframboise, Sarah E Ferguson, Neesha C. Dhani, Marcus O. Butler, Pamela Ng, Terri Stuart-McEwan, Pamela Savage, Lisa Michele Tinker, Amit M. Oza, Stephanie Lheureux
Journal: Journal of Clinical Oncology (2017)

158 Background: Malignant bowel obstruction (MBO) is a common and challenging clinical predicament in women with advanced gynecological cancers. However, there is a lack of evidence-based guidelines or innovative approaches to improve patient care and quality of life. We implemented an inter-professional MBO management program incorporating a nurse-led ambulatory symptom management algorithm and multidisciplinary care conferences (MCC) as hallmarks of this program. Methods: Princess Margaret Cancer Centre has piloted an inter-professional MBO management program that supports women with advanced gynecological cancers who are at risk of/have developed MBO. The MBO team includes oncologists (medical, surgical, gynecologic and radiation), palliative care physicians, diagnostic and interventional radiologists, home parenteral nutrition physicians, specialized oncology nurses, dietitians, pharmacists and social workers. Complex MBO cases are discussed at regular MCC to derive treatment consensus. A symptom-driven MBO management algorithm has been devised and all patients are educated with a personalized bowel symptom management and dietary plan. For outpatient care, patients with MBO are proactively monitored by our specialized oncology nurses via phone or an eHealth bowel application to facilitate communication of symptoms and early intervention. Access to community services and home palliative care services are utilized to support care at home. All patients are enrolled into a prospective database to assess care impact and quality. Results: A total of 145 patients have been followed through the MBO management program over 12 months. At time of data cutoff, 14 had MBO (3 inpatients and 11 outpatients) and 22 were deemed at risk of MBO. Majority patients are managed as an outpatient and avoided unnecessary emergency department episodes. Detailed methodology and data analyses will be presented. Conclusions: A successful novel MBO program incorporating inter-professional care model and nurse-led ambulatory symptom management algorithm optimizes patient care in this vulnerable population and foster collaboration in implementing best practice clinical processes.
Use of Entrustable Professional Activities in the Assessment of Surgical Resident Competency
Authors: Justin P. Wagner, Catherine E. Lewis, Areti Tillou, Vatche G. Agopian, Chi Quach, Timothy R. Donahue, O. Joe Hines
Journal: JAMA Surgery (2017)

Competency-based assessments of surgical resident performance require metrics of entrustable autonomy.To designate entrustable professional activities (EPAs) in global performance and in specific operations, and to identify differences in perceived capability, autonomy, and expectations between surgical faculty and residents.This survey study was conducted from August 9, 2016, through August 24, 2016, in the Department of Surgery at the UCLA David Geffen School of Medicine. The survey instrument consisted of 5-point Likert scales for assessing perceptions of entrustability for 5 global and 5 operative EPAs. Faculty members were surveyed regarding resident capabilities and expected capabilities by postgraduate year. Residents were surveyed regarding their own capabilities, actual autonomy entrusted in the last EPA performed, and expected capabilities.Differences in mean ratings were assessed across 7 comparison domains.Among 78 total faculty members, 31 (40%) participated in the survey. Among 49 residents, 39 (80%) participated in the survey. Residents generally rated their global EPA performance higher than the faculty did (mean, 3.7 vs 2.8; P < .01), but operative EPA performance ratings were equivalent (mean, 2.7 vs 2.4; P < .12). Faculty members perceived senior residents as underperforming expectations in operative EPAs. Most faculty members (80%) expected residents not to be independently capable of performing complex operations by graduation. Faculty members perceived residents in postgraduate years 4 and 5 to have greater operative capability than the level of autonomy entrusted to those residents (95% CI, 3.3-3.5 vs 1.9-2.2).Global and operative EPAs are practical for developing competency-based curricula. Graduated autonomy should be granted to improve the operative experience for residents.
Tumour Vascular Shutdown and Cell Death Following Ultrasound-Microbubble Enhanced Radiation Therapy
Authors: Ahmed El Kaffas, Mehrdad J. Gangeh, Golnaz Farhat, William Tyler Tran, Amr Hashim, Anoja Giles, Gregory J. Czarnota
Journal: Theranostics (2017)

High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage.Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses.This study aimed to confirm acute and longitudinal relationships between vascular shutdown and tumour cell death following radiation and USMB in a wild type murine fibrosarcoma model using in vivo imaging.Methods: Tumour xenografts were treated with single radiation doses of 2 or 8 Gy alone, or in combination with low-/high-concentration USMB.Vascular changes and tumour cell death were evaluated at 3, 24 and 72 h following therapy, using high-frequency 3D power Doppler and quantitative ultrasound spectroscopy (QUS) methods, respectively.Staining using in situ end labelling (ISEL) and cluster of differentiation 31 (CD31) of tumour sections were used to assess cell death and vascular distributions, respectively, as gold standard histological methods.Results: Results indicated a decrease in the power Doppler signal of up to 50%, and an increase of more than 5 dBr in cell-death linked QUS parameters at 24 h for tumours treated with combined USMB and radiotherapy.Power Doppler and quantitative ultrasound results were significantly correlated with CD31 and ISEL staining results (p < 0.05), respectively.Moreover, a relationship was found between ultrasound power Doppler and QUS results, as well as between micro-vascular densities (CD31) and the percentage of cell death (ISEL) (R 2 0.5-0.9).Conclusions: This study demonstrated, for the first time, the link between acute vascular shutdown and acute tumour cell death using in vivo longitudinal imaging, contributing to the development of theoretical models that incorporate vascular effects in radiation therapy.Overall, this study paves the way for theranostic use of ultrasound in radiation oncology as a diagnostic modality to characterize vascular and tumour response effects simultaneously, as well as a therapeutic modality to complement radiation therapy.
P3.02c-091 Final Phase Ib Results of RNActive® Cancer Vaccine BI 1361849 and Local Radiation as Maintenance Therapy for Stage IV NSCLC
Authors: Alexandros Papachristofilou, Martin Sebastian, Christian Weiss, Martin Früh, Miklos Pless, Richard Cathomas, Wolfgang Hilbe, Georg Pall, Thomas Wehler, Jürgen Alt, Helge Bischoff, Michael Geissler, Frank Griesinger, Jens Kollmeier, Madeleine Hipp, Fatma Doener, Mariola Fotin-Mleczek, Henoch Hong, Karl-Josef Kallen, Ute Klinkhardt, Sven Koch, Birgit Scheel, Andreas Schröder, Claudia Stosnach, Ulrike Gnad-Vogt, Alfred Zippelius
Journal: Journal of Thoracic Oncology (2017)
First-line chemotherapy with pemetrexed plus cisplatin for malignant peritoneal mesothelioma
Authors: E. Fujimoto, K. Kuribayashi, S. Kanemura, Y. Negi, Y. Koda, K. Mikami, T. Minami, T. Yokoi, T. Nakano, T. Kijima
Journal: Annals of Oncology (2017)
Coronary Calcium Score and Cardiovascular Risk in Elderly Populations—Reply
Authors: Philip Greenland, Yuichiro Yano, Donald M. Lloyd-Jones
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Focal Autoimmune Pancreatitis Mimicking Pancreatic Cancer on FDG PET/CT Imaging
Authors: Lichun Zheng, Haiqun Xing, Fang Li, Li Huo
Journal: Clinical Nuclear Medicine (2017)

Autoimmune pancreatitis generally results in diffuse increased FDG activity throughout the pancreas on PET/CT images. We present a case of focal autoimmune pancreatitis with abnormal FDG activity involving only the pancreatic tail on PET/CT in a 61-year-old man who was provisionally diagnosed as having pancreatic cancer based on the CT findings. The diagnosis of autoimmune pancreatitis was based on pathological examination and elevated serum immunoglobulin G4 level. Following the steroid therapy, the patient was gradually recovered.
Dissecting Aneurysm of the Aorta
Authors: Bela Gondos, Charles H. Hunter, Nina Braunwald
Journal: New England Journal of Medicine (1959)

WITH the recent development of technics for the successful surgical correction of dissecting aneurysm of the thoracic aorta, the early diagnosis of this entity assumes great importance. The clinical impression, based on the history and physical findings, is often sufficient to raise the suspicion that this condition is present. This disease generally develops at the fifth to the seventh decade and is usually preceded by a history of hypertension. There is a transverse tear in the intima, usually either just above the aortic valve or in the area of the left subclavian artery. The dissection occurs between the layers of . . .
Cardiovascular Disease, Cancer, and Mortality Among People With Type 2 Diabetes and Alcoholic or Nonalcoholic Fatty Liver Disease Hospital Admission
Authors: Sarah H. Wild, Jeremy J. Walker, Joanne R. Morling, David A. McAllister, Helen M. Colhoun, Bassam Farran, Stuart McGurnaghan, Rory McCrimmon, Stephanie H. Read, Naveed Sattar, Christopher D. Byrne, Sarah H. Wild, Jeremy J. Walker, Joanne R. Morling, David A. McAllister, Helen Colhoun, Bassam Farran, Stuart McGurnaghan, Rory McCrimmon, Stephanie H. Read, Naveed Sattar, Christopher D. Byrne, Robert Lindsay, Graham Leese, John McKnight, John Petrie, John Chalmers, Colin Fischbacher, Scott Cunningham, Olivia Wu, Sam Philip
Journal: Diabetes Care (2017)

To describe associations between alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD) hospital admission and cardiovascular disease (CVD), cancer, and mortality in people with type 2 diabetes mellitus (T2DM).We performed a retrospective cohort study by using linked population-based routine data from diabetes registry, hospital, cancer, and death records for people aged 40-89 years diagnosed with T2DM in Scotland between 2004 and 2013 who had one or more hospital admission records. Liver disease and outcomes were identified by using ICD-9 and ICD-10 codes. We estimated hazard ratios (HRs) from Cox proportional hazards regression models, adjusting for key risk factors.A total of 134,368 people with T2DM (1,707 with ALD and 1,452 with NAFLD) were studied, with a mean follow-up of 4.3 years for CVD and 4.7 years for mortality. Among those with ALD, NAFLD, or without liver disease hospital records 378, 320, and 21,873 CVD events; 268, 176, and 15,101 cancers; and 724, 221, and 16,203 deaths were reported, respectively. For ALD and NAFLD, respectively, adjusted HRs (95% CIs) compared with the group with no record of liver disease were 1.59 (1.43, 1.76) and 1.70 (1.52, 1.90) for CVD, 40.3 (28.8, 56.5) and 19.12 (11.71, 31.2) for hepatocellular carcinoma (HCC), 1.28 (1.12, 1.47) and 1.10 (0.94, 1.29) for non-HCC cancer, and 4.86 (4.50, 5.24) and 1.60 (1.40, 1.83) for all-cause mortality.Hospital records of ALD or NAFLD are associated to varying degrees with an increased risk of CVD, cancer, and mortality among people with T2DM.
P2.03b-075 PD-1 Protein Expression Predicts Survival in Resected Adenocarcinomas of the Lung
Authors: Bojan Zaric, Luka Brcic, Anna Buder, Christian Tomuta, Anita Brandstetter, Jorun Buresch, Stefan Traint, Vladimir Stojsic, Tomi Kovacevic, Branislav Perin, Robert Pirker, Martin Filipits
Journal: Journal of Thoracic Oncology (2017)
Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria
Authors: Theodora A. M. Claushuis, Alex F. de Vos, Bernard Nieswandt, Louis Boon, Joris J. T. H. Roelofs, Onno J. de Boer, Cornelis van ’t Veer, Tom van der Poll
Journal: Blood (2017)
Brote de listeriosis asociado al consumo de sandwiches vendidos en un hospital, Reino-Unido
Authors: S J Dawson, M R Evans, D Willby, J Bardwell, N Chamberlain, D A Lewis
Journal: Eurosurveillance (2006)

En otono de 2003 tuvo lugar un brote de listeriosis en la region de Swindon, Reino Unido. Se detectaron cinco casos en mujeres embarazadas. Es probable que cuatro de ellas hubieran comido sandwiches pre-empaquetados comprados en el mismo hospital. La cepa de Listeria monocytogenes identificada en las muestras procedentes del proveedor no se pudo distinguir de la aislada por tipificacion molecular en las pacientes. Los cambios recientes de la normativa sobre alimentos en el Reino Unido deberian contribuir a la disminucion del riesgo de nuevos brotes o casos como el descrito en este articulo.
Abstract 17893: Reducing Radiation Exposure and Contrast Use in Pre-TAVR Evaluation by Computed Tomography Angiography (CTA): A Quality Improvement Project
Authors: Eric M Holland, Adrian I Loffler, Jorge A Gonzalez, Cynthia K Lamie, Peter W Shaw, Pelbreton C Balfour, Christopher M Kramer, Michael Salerno, Klaus Hagspiel, Patrick Norton
Journal: Circulation (2016)

Introduction: Aortic stenosis is the most common valvular heart disease with a prevalence of 13% in patients ≥75 years of age. Transcatheter aortic valve replacement (TAVR) has become a widely util...
Aspirin and Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study
Authors: Ka Shing Cheung, Esther W Chan, Angel Y S Wong, Lijia Chen, Wai Kay Seto, Ian C K Wong, Wai K Leung
Journal: JNCI Journal of the National Cancer Institute (2017)

Despite successful H. pylori (HP) eradication, some individuals remain at risk of developing gastric cancer (GC). Previous studies showed that aspirin was associated with a reduced GC risk. However, whether aspirin can reduce GC risk in HP-eradicated subjects remains unknown. We aimed to determine the chemopreventive effect of aspirin in HP-eradicated subjects.We identified subjects who had received a prescription of clarithromycin-based triple therapy for HP between 2003 and 2012 from a territory-wide health care database. The observation period started from commencement of HP therapy (index date), and the follow-up was censored at the end of the study (December 2015), death, or GC diagnosis. Aspirin use was defined as use once or more often weekly. Subjects who failed HP eradication or were diagnosed with GC within 12 months of HP therapy were excluded. The hazard ratio (HR) of GC with aspirin use was calculated by Cox model with Propensity Score adjustment for age, sex, comorbidities, and concurrent medications. All statistical tests were two-sided.The median follow-up was 7.6 years (interquartile range [IQR] = 5.1-10.3 years), and 169 (0.27%) out of 63 605 patients developed GC. The incidence rate of GC was 3.5 per 10 000 person-years. Aspirin use was associated with a reduced GC risk (HR = 0.30, 95% confidence interval [CI] = 0.15 to 0.61). The risk of GC decreased with increasing frequency, duration, and dose of aspirin (all Ptrend < .001).Aspirin use was associated with a frequency-, dose-, and duration-dependent reduction in GC risk after HP eradication. The effect was most prominent in those who used aspirin daily or for five or more years.
Effect of palliative surgery, chemotherapy, and radiation in stage IV pancreatic cancer.
Authors: Brooke Vuong, Ahmed Dehal, Amanda N Graff-Baker, Shu-Ching Chang, Leland Foshag, Anton Bilchik, Melanie R Goldfarb
Journal: Journal of Clinical Oncology (2017)

e15707 Background: Despite significant advances in multi-modality treatment for pancreatic adenocarcinoma (PC), prognosis for stage IV PC remains poor. While reducing suffering and optimizing quality of life are the primary goals of palliative therapies, these interventions may extend overall survival. We examined the impact on survival when aggressive palliative treatments including surgery, chemotherapy, or radiation were employed in end-of-life care. Methods: The 2004-2014 National Cancer Data Base (NCDB) was queried to identify patients with stage IV PC that did not undergo primary surgical resection. Univariate (Kaplan Meier and log-rank) and multivariable (Cox proportional hazard) analyses were used to assess the associations between patient characteristics, use of palliative therapies, and overall survival. Results: Of 72,736 patients identified with metastatic stage IV PC, 2,097 (3%) underwent surgical palliation (ST), 5,615 (8%) received palliative chemotherapy (CT), 940 (1%) received palliative radiation (RT), 1,163 (2%) received multimodality treatment (MMT), and 62,921 (87%) had no aggressive palliative intervention (NT). The choice of palliative therapy, if any, was influenced by all demographic and tumor variables except for gender (all p &lt; 0.001). Median OS was greatest after CT (5.09 months, p &lt; 0.001) compared to any other modality (NT: 3.45months, ST: 3.71months, RT: 3.25months, MMT: 4.47months). This remained true regardless of age, gender, race/ethnicity, insurance, and facility type. After adjusting for all demographic and tumor factors, use of CT decreased the annual risk of death by 20% (HR = 0.8; 95%CI [0.77, 0.82]) and MMT by 10% (HR = 0.9; 95%CI [0.84, 0.96]). Employment of RT increased risk of death by 9% (HR = 1.09; 95%CI [1.01, 1.17]) and ST did not affect OS (HR = 1.01; 95%CI [0.96,1.06]). Conclusions: Despite advances in palliative treatments, Stage IV PC arries a dismal prognosis. Palliative RT may shorten survival. Equivalent survival for ST versus NT suggests that this may be beneficial in the appropriate patient. Palliative CT independently improved survival by approximately 6 weeks and should be considered in patients that want to extend survival and can tolerate the toxicity.