tbuckley/cabot-search huggingface dataset:
神経行動学的表現型:ATXN1‐CIC複合体の破壊がマウスとヒトにおいて一連の神経行動学的表現型を引き起こす
Authors: LU Hsiang‐Chih, Yeh Szu‐Ying, Sillitoe Roy, Zoghbi Huda Y, Tan Qiumin, Rousseaux Maxime W C, Wang Wei, Kim Ji‐Yoen, Richman Ronald, Wan Ying‐Wooi, Liu Xiuyun, Lin Tao, Lee Yoontae, Fryer John D, Han Jing, Ljungberg M Cecilia, Liu Zhandong, Schaaf Christian P, Chahrour Maria, Bainbridge Matthew N, Patel Jay M, Finnell Richard H, Lei Yunping, Zurita‐Jimenez Maria E, Ahimaz Priyanka, Anyane‐Yeboa Kwame, Maldergem Lionel Van, Lehalle Daphne, Jean‐Marcais Nolwenn, Mosca‐Boidron Anne‐Laure, Thevenon Julien, Cousin Margot A, Bro Della E, Lanpher Brendan C, Klee Eric W, Alexander Nora, Orr Harry T
Journal: Nature Genetics (2017)
AB0391 Similar pharmacokinetics, safety and tolerability of the adalimumab biosimilar candidate BI 695501 administered subcutaneously via prefilled syringe (PFS) or autoinjector (AI) (voltaire®-ai)
Authors: S Ramael, V Moschetti, N Peter, I Sonderegger, S Wiebe, B Liedert
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> PK bioequivalence of BI 695501, an adalimumab biosimilar candidate, and the adalimumab originator was demonstrated previously (VOLTAIRE®-PK: Wynne et al., Expert Opin Investig Drugs 2016;25:1361–70). Administration in chronic inflammatory diseases benefits from patient-friendly PFSs or AIs, the development of which requires assessment of PK, safety, immunogenicity, and local tolerability. <h3>Objectives</h3> To compare PK, safety, immunogenicity, and tolerability of BI 695501 after subcutaneous (SC) injection using either a PFS or an AI. <h3>Methods</h3> In this 16-week randomised, single-dose, open-label, parallel-group study (NCT02606903), 40mg BI 695501 was administered either via PFS or AI in healthy, Caucasian, male, non-athletic volunteers aged 18–65 years with body mass index (BMI) of ≥18 to ≤30 kg/m<sup>2</sup>. The study end points included AUC<sub>0–1032</sub>, C<sub>max</sub>, and AUC<sub>0–∞</sub>, analysed using an ANOVA model with fixed effects for treatment and BMI group. Safety assessment included the proportion of subjects with drug-related adverse events (AEs). Immunogenicity parameters were: proportion of subjects with binding/neutralising anti-drug antibodies (ADAs), and ADA titers. <h3>Results</h3> Seventy-one volunteers were randomised: PFS, n=36; AI, n=35. Key demographic and baseline characteristics were well balanced between the treatment groups. PK end point results are shown in Table 1. Estimates for AI/PFS geometric mean (gMean) ratios were within the standard bioequivalence acceptance range (80–125%). Mean plasma concentration-time profiles and total exposure for BI 695501 administered via PFS or AI were similar over the observation period; treatment-emergent AEs (TEAEs) and administration site conditions (ASC) are shown in Table 2. Similar frequencies of patients tested positive for ADAs (57.6% in the PFS group and 51.5% in the AI group), and for neutralising antibodies (33.3%% in the PFS group and 30.3% in the AI group) at the end of the study. <h3>Conclusions</h3> PK, safety, tolerability, and immunogenicity of BI 695501 after SC injection with a PFS or an AI were comparable. <h3>Disclosure of Interest</h3> : S. Ramael: None declared, V. Moschetti Employee of: Boehringer Ingelheim, N. Peter Employee of: Boehringer Ingelheim, I. Sonderegger Employee of: Boehringer Ingelheim, S. Wiebe Employee of: Boehringer Ingelheim, B. Liedert Employee of: Boehringer Ingelheim
Stimulating Effect of Estrogen on Replication of Rat Mammary-Tumor-Derived Virus (BV-1) in Rat-Embryo Cell Cultures&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: Victor V. Bergs
Journal: JNCI Journal of the National Cancer Institute (1972)

Stimulating Effect of Estrogen on Replication of Rat Mammary-Tumor-Derived Virus (BV-1) in Rat-Embryo Cell Cultures Get access Victor V. Bergs Victor V. Bergs Department of Microbiology, University of Miami School of Medicine, Bratislava, Czechoslovakia Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 48, Issue 4, April 1972, Page 1244, https://doi.org/10.1093/jnci/48.4.1244 Published: 01 April 1972
Violence Against Women
Authors: M. J. Friedrich
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gender Differences in the Development of CMR Abnormalities and Cardiac Complications: A Multicentric Prospective Study in a Large Cohort of Thalassemia Major Patients
Authors: Alessia Pepe, Silvia Maffei, Laura Pistoia, Angela Ciancio, Giovanni Palazzi, Crocetta Argento, Lucia De Franceschi, Maurizio Mangione, Antonino Vallone, Massimiliano Missere, Vincenzo Positano, Antonella Meloni
Journal: Blood (2016)
Network-Based Identification of Adaptive Pathways in Evolved Ethanol-Tolerant Bacterial Populations
Authors: Toon Swings, Bram Weytjens, Thomas Schalck, Camille Bonte, Natalie Verstraeten, Jan Michiels, Kathleen Marchal
Journal: Molecular Biology and Evolution (2017)

Efficient production of ethanol for use as a renewable fuel requires organisms with a high level of ethanol tolerance. However, this trait is complex and increased tolerance therefore requires mutations in multiple genes and pathways. Here, we use experimental evolution for a system-level analysis of adaptation of Escherichia coli to high ethanol stress. As adaptation to extreme stress often results in complex mutational data sets consisting of both causal and noncausal passenger mutations, identifying the true adaptive mutations in these settings is not trivial. Therefore, we developed a novel method named IAMBEE (Identification of Adaptive Mutations in Bacterial Evolution Experiments). IAMBEE exploits the temporal profile of the acquisition of mutations during evolution in combination with the functional implications of each mutation at the protein level. These data are mapped to a genome-wide interaction network to search for adaptive mutations at the level of pathways. The 16 evolved populations in our data set together harbored 2,286 mutated genes with 4,470 unique mutations. Analysis by IAMBEE significantly reduced this number and resulted in identification of 90 mutated genes and 345 unique mutations that are most likely to be adaptive. Moreover, IAMBEE not only enabled the identification of previously known pathways involved in ethanol tolerance, but also identified novel systems such as the AcrAB-TolC efflux pump and fatty acids biosynthesis and even allowed to gain insight into the temporal profile of adaptation to ethanol stress. Furthermore, this method offers a solid framework for identifying the molecular underpinnings of other complex traits as well.
Impaired humoral and cellular immune responses to influenza vaccination in chronic obstructive pulmonary disease patients
Authors: Aurélien Parpaleix, Laurent Boyer, Aurelie Wiedemann, Christine Lacabaratz, Laurent Margarit, Vincent Enouf, Philippe Le Corvoisier, Anne Lino, Ala Covali-Noroc, Bruno Housset, Christos Chouaid, Bernard Maitre, Yves Lévy, Jean-Daniel Lelièvre, Serge Adnot
Journal: Journal of Allergy and Clinical Immunology (2017)
標的化癌治療のためのヒアルロン酸被覆酸化グラフェンを用いた内因性miR‐21のin vivo可視化【Powered by NICT】
Authors: Hwang Do Won, Kim Han Young, Li Fangyuan, Park Ji Yong, Kim Dohyun, Park Jae Hyung, Han Hwa Seung, Byun Jung Woo, Lee Yun-Sang, Jeong Jae Min, Char Kookheon, Lee Dong Soo
Journal: Biomaterials (2017)
心臓修復のための幹細胞を含む脱細胞化細胞外マトリックスbioinksを用いた3Dプリント複合組織構築物【Powered by NICT】
Authors: Jang Jinah, Park Hun-Jun, Kim Seok-Won, Kim Heejin, Park Ju Young, Na Soo Jin, Kim Hyeon Ji, Park Moon Nyeo, Choi Seung Hyun, Park Sun Hwa, Kim Sung Won, Kwon Sang-Mo, Kim Pum-Joon, Cho Dong-Woo
Journal: Biomaterials (2017)
Critical Roles of Α-Type Lamins in Neutrophil Differentiation Revealed By Analyses of Lmna Trancriptional Regulation and Myeloid Models with Aberrant Lamin Α Expression
Authors: Margery G.H. Pelletier, Krishnakumar Malu, Klaudia Szymczak, Anna M Barbeau, Gianna N Prata, Kevin S O'Fallon, Peter Gaines
Journal: Blood (2016)
Environmental surveillance during an outbreak of tularaemia in hares, the Netherlands, 2015
Authors: Ingmar Janse, Miriam Maas, Jolianne M Rijks, Miriam Koene, Rozemarijn QJ van der Plaats, Marc Engelsma, Peter van der Tas, Marieta Braks, Arjan Stroo, Daan W Notermans, Maaike C de Vries, Frans Reubsaet, Ewout Fanoy, Corien Swaan, Marja JL Kik, Jooske IJzer, Ryanne I Jaarsma, Sip van Wieren, Ana Maria de Roda-Husman, Mark van Passel, Hendrik-Jan Roest, Joke van der Giessen
Journal: Eurosurveillance (2017)

Tularaemia, a disease caused by the bacterium Francisella tularensis , is a re-emerging zoonosis in the Netherlands. After sporadic human and hare cases occurred in the period 2011 to 2014, a cluster of F. tularensis -infected hares was recognised in a region in the north of the Netherlands from February to May 2015. No human cases were identified, including after active case finding. Presence of F. tularensis was investigated in potential reservoirs and transmission routes, including common voles, arthropod vectors and surface waters. F. tularensis was not detected in common voles, mosquito larvae or adults, tabanids or ticks. However, the bacterium was detected in water and sediment samples collected in a limited geographical area where infected hares had also been found. These results demonstrate that water monitoring could provide valuable information regarding F. tularensis spread and persistence, and should be used in addition to disease surveillance in wildlife.
多価と相乗的相互作用によるサブ30nm telodendrimerナノキャリアへの親和性制御蛋白質カプセル封じ【Powered by NICT】
Authors: Wang Xu, Shi Changying, Zhang Li, Bodman Alexa, Guo Dandan, Wang Lili, A Hall Walter, Wilkens Stephan, Luo Juntao
Journal: Biomaterials (2016)
High-dose ustekinumab for severe childhood deficiency of interleukin-36 receptor antagonist (DITRA)
Authors: Nadia Bonekamp, Roberta Caorsi, Gian Maria Viglizzo, Marlies de Graaf, Francesca Minoia, Alice Grossi, Paolo Picco, Isabella Ceccherini, Joost Frenkel, Marco Gattorno
Journal: Annals of the Rheumatic Diseases (2017)

Deficiency of the interleukin-36 receptor antagonist (DITRA) is an autosomal recessive disease caused by mutations of IL36RN gene.1 Patients suffer from flares of acute generalised pustular psoriasis and systemic inflammation. We present two paediatric cases of DITRA with a severe clinical course, resistant to multiple therapies in whom the use of high doses of ustekinumab (a monoclonal antibody against the p40 subunit of both IL-12 and IL-23) lead to a persistent control of the disease.

A 4-year-old boy, born from unrelated parents, presented at the age of 3 years with inverse psoriasis in the genital area. After some months, he developed diffuse pustular lesions associated with fever, elevation of acute phase reactants and poor general condition, requiring parenteral antibiotics and high-dose steroids (figure 1). Compound heterozygosity for the IL36RN P76L/S113L mutations was detected. Different treatments (acitretin, high-dose ciclosporin, …
HFWM: - Title: Adiponectin and 4-hydroxynonenal as messengers in the cross-talk between the heart and epicardial adipose tissue regulating myocardial redox state in ischemic heart disease
Authors: A Antonopoulos, M Margaritis, A Recalde, P Ciccone, S Reilly, A Shah, D Tousoulis, B Casadei, C Antoniades, K M Channon
Journal: European Journal of Heart Failure (2014)
Consensus-based recommendations for the use of biosimilars to treat rheumatological diseases
Authors: Jonathan Kay, Monika M Schoels, Thomas Dörner, Paul Emery, Tore K Kvien, Josef S Smolen, Ferdinand C Breedveld
Journal: Annals of the Rheumatic Diseases (2017)

The study aimed to develop evidence-based recommendations regarding the evaluation and use of biosimilars to treat rheumatological diseases. The task force comprised an expert group of specialists in rheumatology, dermatology and gastroenterology, and pharmacologists, patients and a regulator from ten countries. Four key topics regarding biosimilars were identified through a process of discussion and consensus. Using a Delphi process, specific questions were then formulated to guide a systematic literature review. Relevant English-language publications through November 2016 were searched systematically for each topic using Medline; selected papers and pertinent reviews were examined for additional relevant references; and abstracts presented at the 2015 and 2016 American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) annual scientific meetings were searched for those about biosimilars. The experts used evidence obtained from these studies to develop a set of overarching principles and consensus recommendations. The level of evidence and grade of recommendation were determined for each. By the search strategy, 490 references were identified. Of these, 29 full-text papers were included in the systematic review. Additionally, 20 abstracts were retrieved from the ACR and EULAR conference abstract databases. Five overarching principles and eight consensus recommendations were generated, encompassing considerations regarding clinical trials, immunogenicity, extrapolation of indications, switching between bio-originators and biosimilars and among biosimilars, and cost. The level of evidence and grade of recommendation for each varied according to available published evidence. Five overarching principles and eight consensus recommendations regarding the evaluation and use of biosimilars to treat rheumatological diseases were developed using research-based evidence and expert opinion.
パーキンソン病に対するアクチビンBに基づくドラッグデリバリーヒドロゲル系【Powered by NICT】
Authors: Li Juan, Darabi Mohammadali, Gu Jingjing, Shi Junbin, Xue Jinhua, Huang Lu, Liu Yutong, Zhang Lei, N Liu, Zhong Wen, Zhang Lin, Xing Malcolm, Zhang Lu
Journal: Biomaterials (2016)
マクロファージ活性化状態は異なるサイズのメソ多孔質シリカ粒子のインターナリゼーションを決定する:異なるパターン認識受容体の役割の調査【Powered by NICT】
Authors: Gallud Audrey, Bondarenko Olesja, Feliu Neus, Kupferschmidt Natalia, Atluri Rambabu, Garcia-Bennett Alfonso, Fadeel Bengt
Journal: Biomaterials (2017)
Induction of leukocyte infiltration in three-dimensional tumor spheroids by anti-EGFR antibodies
Authors: Thomas K. Hoffmann, Vera Balz, Kerstin Schirlau, Anja Müller, Torsten Reichert, Ulrike Friebe-Hoffmann, Murat Bas, Theresa L. Whiteside, Henning Bier
Journal: Cancer Research (2004)

1254   Overexpression of the epidermal growth factor receptor (EGFR) is a hallmark of squamous cell carcinoma of the head and neck (SCCHN), and EGFR-mediated cellular events modulate a variety of biological features which determine the malignant phenotype. Hence, the EGFR is considered to be an interesting target for antitumor treatment strategies. As the receptor is located at the cell surface, monoclonal antibodies (mab) are suitable agents for the exploration of this approach. We generated a three dimensional spheroid model of EGFR overexpressing SCCHN in order to study leukocyte infiltration potentially induced by humanized anti-EGFR mab EMD 72000 (Merck, Darmstadt, Germany). The presence of EMD 72000 led to substantially increased infiltration of peripheral blood mononuclear cells (PBMC), further characterized as NK- and T-cells. To elucidate this chemotactic effect, we investigated the expression of cytokines and chemokines in cDNA-macroarrays. Blockade of EGFR with EMD 72000 led to differential expression of MMP-10, BMP-2, MCP-1, MMP-1, IL-1beta, and IL-1alpha. The most promising candidate for chemotactic modulation of PBMC infiltration, MCP-1 showed significant upregulation in quantitative PCR and ELISPOT assays in SCCHN upon EMD 72000 exposure. However, so far spheroid infiltration experiments with blocking MCP-1 mab did not confirm its supposed chemotactic effect. EMD 72000 upregulates chemotactic cytokines in SCCHN and induces leukocyte infiltration in three-dimensional SCCHN spheroids, thereby characterizing an additional mode of EGFR mab action for potential anticancer therapy.
エキソソーム模倣ナノベシクルによるRNAiデリバリー 癌におけるc‐Mycを標的とするための意義【Powered by NICT】
Authors: R Lunavat Taral, Jang Su Chul, Nilsson Lisa, Park Hyun Taek, Repiska Gabriela, Laesser Cecilia, A Nilsson Jonas, Gho Yong Song, Lotvall Jan
Journal: Biomaterials (2016)
Notch/HES1/DTX1 signaling controls osteosarcoma invasiveness and metastasis in vivo.
Authors: Pingyu Zhang, Yanwen Yang, Patrick Zweidler-McKay, Dennis Hughes
Journal: Cancer Research (2008)

1984   Osteosarcoma, the most common malignant tumor of bone in teenagers, has high potential of pulmonary metastasis. Although primary osteosarcoma is effectively treated by surgery and chemotherapy, pulmonary metastasis is more difficult to control and causes the majority of patient death. Elimination of metastatic disease is essential to cure osteosarcoma patients. However, the molecular mechanisms controlling invasiveness and metastasis are not fully understood. Previously, we identified an essential role of Notch in osteosarcoma invasiveness  in vitro . We found that γ-secretase inhibitor-mediated blockade of Notch reduced matrigel invasion in parallel with HES1 reduction in osteosarcoma cell lines OS187 and LM7, but had no effect on proliferation, survival or anchorage-independent growth. Furthermore, overexpression of constitutively active Notch1 (ICN1, intercellular domain of Notch1), HES1 or dominant negative Mastermind (dnMAM, an inhibitor of Notch signaling) confirmed the essential role of Notch-induced HES1 expression in promoting invasion of osteosarcoma cells. Here, we further identify the essential role of Notch/Hes1 signaling in osteosarcoma invasiveness  in vitro  and metastasis  in vivo . Using our orthotopic osteosarcoma mouse model, we found that inhibiting Notch signaling with dnMAM significantly suppressed the pulmonary metastasis of osteosarcoma  in vivo  ( p  in vitro . The role of HES1 in osteosarcoma invasiveness was also confirmed using shRNAs targeting HES1 in osteosarcoma cells. Overexpression of the shRNAs in osteosarcoma cells suppressed HES1 expression at the mRNA and protein levels, and also inhibited the invasiveness of osteosarcoma cells. In one osteosarcoma cell line, COL, which has high endogenous DTX1, we also found that HES1 can inhibit the expression of DTX1. Consistently, we found that overexpression of dnHES1 in osteosarcoma and neuroblstoma cells can upregulate DTX1 expression. Using ChromatinIP techniques, we confirmed that HES1 can bind to the promoter of DTX1 directly. We also indentified the binding site of HES1 in DTX1 promoter. Our studies demonstrate the role of Notch/HES1 signaling in osteosarcoma invasiveness and metastasis  in vitro  and  in vivo . Our data also illustrate a novel regulatory mechanism between the downstream target genes HES1 and DTX1. Since Notch pathway is a potential target for human cancer, our work may have important implications for prediction of which patients are at increased risk for metastasis and might benefit from γ-secretase inhibitor treatment.
HLA class I and class II polymorphism in Croatian patients with psoriatic arthritis
Authors: Zorana Grubic, Porin Perić, Esma Čečuk-Jeličić, Vesna Brkljačić-Kerhin, Božidar Ćurković, Andrija Kaštelan
Journal: Annals of the Rheumatic Diseases (2002)

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis which is caused by a combination of genetic and environmental factors. The identification of genetic markers for PsA would be of great benefit for diagnosis. The aim of this study was to investigate contribution of HLA-A, -B, -Cw and -DRB1 alleles in the susceptibility to PsA. Fifty-five unrelated patients with PsA (30 women and 25 men, mean age 46 years) were analysed. DNA was isolated by standard salting out protocol, while HLA typing was performed by Polymerase Chain Reaction -Sequence Specific Primers (PCR-SSP) method. The results were compared with a sample of 141 healthy unrelated individuals using Chi-square test with Yates correction and the Fischer's exact test. The relative risk for estimating the strenght of association of the disese with a given allele was calculated by means of Woolf's method. Our results showed that none of 15 distinct HLA-A alleles was increased or decreased in the PsA group, while among 19 different alleles at HLA-B locus 3 alleles showed statistically significant differences between two tested groups. Allele B*13 (7.3% vs 2.6%, p=0.023), B*39 (14.5% vs 2.4%, p=0.0001) and B*27 (15.5% vs 5.0%, p=0.0003) were increased. At HLA-Cw locus, twenty-two patients were Cw*07 (40.4% vs 18.1%, p=0.002) and thirteen patients were positive for Cw*0602 allele (23.1% vs 9.7%, p=0.02). Among HLA-DRB1 alleles, DRB1*0701 showed significant increase in patients with PsA (15.7% vs 7.8%, p=0.019). Results indicated that the higest relative risk (RR) was observed for B*39 (RR=6.19) followed by B*27 (RR=4.25), B*13 (RR=3.40), Cw*07 (RR=3.07), Cw*0602 (RR=2.93) and DRB1*0701 (RR=2.68). The data obtained in this study are consistent with the polygenic inheritance of PsA. Allele B*39 appears to be the strongest genetic susceptibility factor for disease. Further study with larger number of PsA patients is necessary to confirm these findings and to elucidate a possible role of non- HLA loci in the region between HLA B and Cw loci in the susceptibility to PsA.
Using Genotype Abundance to Improve Phylogenetic Inference
Authors: William S DeWitt, Luka Mesin, Gabriel D Victora, Vladimir N Minin, Frederick A Matsen
Journal: Molecular Biology and Evolution (2018)

Modern biological techniques enable very dense genetic sampling of unfolding evolutionary histories, and thus frequently sample some genotypes multiple times. This motivates strategies to incorporate genotype abundance information in phylogenetic inference. In this article, we synthesize a stochastic process model with standard sequence-based phylogenetic optimality, and show that tree estimation is substantially improved by doing so. Our method is validated with extensive simulations and an experimental single-cell lineage tracing study of germinal center B cell receptor affinity maturation.