tbuckley/cabot-search huggingface dataset:
Benefits of Individualized Feedback in Internet-Based Interventions for Depression: A Randomized Controlled Trial
Authors: Pavle Zagorscak, Manuel Heinrich, Daniel Sommer, Birgit Wagner, Christine Knaevelsrud
Journal: Psychotherapy and Psychosomatics (2018)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Even though there is an increasing number of studies on the efficacy of Internet-based interventions (IBI) for depression, experimental trials on the benefits of added guidance by clinicians are scarce and inconsistent. This study compared the efficacy of semistandardized feedback provided by psychologists with fully standardized feedback in IBI. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Participants with mild-to-moderate depression (&lt;i&gt;n = &lt;/i&gt;1,089, 66% female) from the client pool of a health insurance company participated in a cognitive-behavioral IBI targeting depression over 6 weeks. Individuals were randomized to weekly semistandardized e-mail feedback from psychologists (individual counseling; IC) or to automated, standardized feedback where a psychologist could be contacted on demand (CoD). The contents and tasks were identical across conditions. The primary outcome was depression; secondary outcomes included anxiety, rumination, and well-being. Outcomes were assessed before and after the intervention and 3, 6, and 12 months later. Changes in outcomes were evaluated using latent change score modeling. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Both interventions yielded large pre-post effects on depression (Beck Depression Inventory-II: &lt;i&gt;d&lt;/i&gt;&lt;sub&gt;IC&lt;/sub&gt; = 1.53, &lt;i&gt;d&lt;/i&gt;&lt;sub&gt;CoD&lt;/sub&gt; = 1.37; Patient Health Questionnaire-9: &lt;i&gt;d&lt;/i&gt;&lt;sub&gt;IC&lt;/sub&gt; = 1.20, &lt;i&gt;d&lt;/i&gt;&lt;sub&gt;CoD&lt;/sub&gt; = 1.04), as well as significant improvements of all other outcome measures. The effects remained significant after 3, 6, and 12 months. The groups differed with regard to attrition (IC: 17.3%, CoD: 25.8%, &lt;i&gt;p&lt;/i&gt; = 0.001). Between-group effects were statistically nonsignificant across outcomes and measurement occasions. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Adding semistandardized guidance in IBI for depression did not prove to be more effective than fully standardized feedback on primary and secondary outcomes, but it had positive effects on attrition.
Blisters in disguise
Authors: EA Dowlatshahi, GFH Diercks, MBA van Doorn
Journal: BMJ (2018)

A 77 year old man with a history of hypertension, angina pectoris, chronic obstructive pulmonary disease, and prostate hyperplasia presented to the dermatology department with a 6 month history of thick, oozing, foul smelling skin lesions in the groin and around the umbilicus (fig 1), and erosions on the lips. He was mostly concerned about the smell from the lesions and the painful lip erosions, which made it difficult to eat. He had lost 7 kg in the past six months.



Fig 1 
Vegetating periumbilical and inguinal plaques



His medication included metoprolol, isosorbide mononitrate, seretide, flixonase, tamsulosine, and desloratadine.

Physical examination revealed swollen, erosive lips with rhagades and crusts. He had thick oozing inguinal and periumbilical papillomatous plaques.

Laboratory studies showed erythrocyte sedimentation rate of 47 mm/h (normal range <20 mm/h) and mild eosinophilia (12.8% of leucocytes, normal range 1.4-6.2% of leucocytes) with a normal leucocyte count (normal range 3.5-10.0×109/L).

Histopathologic examination of skin biopsy from the groin showed a broadened epidermis with elongation of the rete ridges with focal hyperkeratosis and abscesses in the hair follicles, and a dense plasma cell infiltrate. Immunofluorescence of perilesional skin showed intercellular depositions of IgG, IgA, and C3 complement, and enzyme linked immunosorbent assay showed IgG antibodies directed against desmoglein 3.



### 1. What is the most likely diagnosis and how is the condition diagnosed?

#### Short answer

Diagnosis of pemphigus vegetans, a subtype of pemphigus vulgaris, is based on the typical clinical appearance, immunofluorescence, and enzyme linked immunosorbent assay. Direct immunofluorescence on perilesional skin shows intercellular depositions …
Association between mean systolic and diastolic blood pressure throughout the follow‐up and cardiovascular events in acute myocardial infarction patients with systolic dysfunction and/or heart failure: an analysis from the High‐Risk Myocardial Infarction Database Initiative
Authors: João Pedro Ferreira, Kevin Duarte, Marc A. Pfeffer, John J.V. McMurray, Bertram Pitt, Kenneth Dickstein, Faiez Zannad, Patrick Rossignol
Journal: European Journal of Heart Failure (2018)
Ultrastructural measures of glomerular extracellular matrix accumulation in non-proteinuric type 2 diabetic patients.
Authors: P Fioretto, M Mauer, I Velussi, A Carraro, B Muollo, E Brocco, B. Baggio, G Crepaldi, R. Nosadini
Journal: Journal of the American Society of Nephrology (1996)
A Xenograft Model of Lymphocyte-Independent, Effector-Driven Macrophage Activation SyndRome Amenable to Anti-CD33 and Anti-IL-6R Treatment
Authors: Mark Wunderlich, Courtney Stockman, Mahima Devarajan, Navin Ravishankar, Christina Sexton, Ashish R Kumar, Benjamin Mizukawa, James C. Mulloy
Journal: Blood (2016)
Endogenous and exogenous sex steroid hormones in asthma and allergy in females: A systematic review and meta-analysis
Authors: Nicola McCleary, Bright I. Nwaru, Ulugbek B. Nurmatov, Hilary Critchley, Aziz Sheikh
Journal: Journal of Allergy and Clinical Immunology (2018)

Endogenous and exogenous sex steroid hormones
Depth of Response to ≥VGPR at Completion of Induction Influences Outcome Post ASCT, on Behalf of the Tunisian Myeloma Study Group
Authors: Raoudha Mansouri, Rim El fatmi, Héla Ghédira, Faten Kallel, Nour Ben Abdejelil, Kmira Zahra, Neila Ben Romdhane, Salma Kéfi, Moez Medhaffer, Zeineb Manai, Nesrine Ben Sayed, Manel Bchir, Mohamed Zarrouk, Sami Zriba, Sarra Boukhris, Ines Safra, Mounira Meddeb, Adnene Laatiri, Moez Elloumi, Fehmi M'Sadek, Abderrahmen Khélif, Balkis Meddeb, Xavier Leleu, Tarek Ben Othmen
Journal: Blood (2016)
Abstract MP70: Impact of Cardiovascular Health Metrics on Life Expectancy and All-cause Mortality in Middle-aged and Elderly Men and Women
Authors: Chong-Do Lee, Tongyu MA
Journal: Circulation (2016)

Purpose: We investigated the combined impact of 7 ideal cardiovascular health metrics on life expectancy and lifetime risk of all-cause mortality in middle-aged and elderly US men and women. Methods: Cox proportional hazards regression was used to examine the associations of single and combined number of 7 health metrics and all-cause mortality after adjustment for multiple risk factors. Survival analysis (modified version) was used to compute lifetime risk of all-cause mortality at 40 years of age to 80, with death free of chronic diseases as a competing event. We followed 7,848 men and women, aged 40 to 80 years, who participated in the Third National Health and Nutrition Examination Survey. All participants completed baseline lifestyle factors and lifestyle behavior questionnaires. The 7 ideal cardiovascular health metrics were defined as physically active, never smoked, a healthy diet, waist girth (&lt;102/88 cm), untreated blood pressure (&lt;120/80 mmHg), untreated total cholesterol (&lt;200 mg/dL), and untreated fasting glucose (&lt;100 mg/dL) defined by the American Heart Association (AHA). We further categorized these variables as having 0, 1, 2, 3, 4, 5, 6 or 7 combined cardiovascular health metrics. Results: During an average of 13.2 years of follow-up (103,851 person-years), there were a total of 2,297 all-cause deaths (915 CVD, 546 cancer, 210 respiratory disease, 86 diabetes mellitus). After adjustment for multiple risk factors, men and women with all 6 or 7 combined ideal health metrics had a 68% (95% CI: 43% to 83%) lower risk of all-cause mortality compared with men and women with zero ideal health metrics. The lifetime risks of all-cause mortality (at 40 years of age) across 0, 1, 2, 3, 4, 5, and 6 or 7 ideal health metrics were (95% CI) 60.2% (55.6, 64.8), 51.9% (48.4, 55.4), 43.6% (40.3, 46.9), 37.1% (33.0, 41.3), 35.1% (29.6, 40.5), 33.8% (24.8, 42.8), and 19.4% (5.1, 33.7), respectively. Men and women with increasing number ideal health metrics had a substantially lower lifetime risk of all-cause mortality. Men and women with 6 or 7 compared with 0 combined ideal health metrics had a longer life expectancy by 13.5 years (95% CI: 6.8 to 19.5 years). Approximately 53% (95% CI: 15% to 74%) of all-cause deaths might have been avoided if men and women had adopted all 6 or 7 combined health factors and healthy lifestyle behaviors. Conclusion: Adopting the AHA’s 7 ideal cardiovascular health metrics is associated with lower lifetime risk of all-cause mortality and longer life expectancy in middle-aged and elderly US men and women.
A Retrospective Multicenter Analysis of the Safety and Efficacy of Brentuximab Vedotin (BV) As Monotherapy or in Combination with Bendamustine (BV-B) in Relapsed Refractory Classic Hodgkin Lymphoma (cHL) in Argentina
Authors: Florencia Negri Aranguren, Santiago Cranco, Claudia Shanley, Isolda I. Fernandez, Maria Virginia Prates, Victoria Otero, Lorena Fiad, Maria Cecilia Foncuberta, Marcela Miodosky, Miguel A. Pavlovsky, Gustavo Kuminsky, Javier Bordone, Bruno Wannesson, Ariel Corso Corso, Dardo Riveros, Marisa Marquez, Gustavo Jarchum, Maria Sol Jarchum, Ider Ramon Cerutti, Alicia Bistmas, Monica Tamashiro, Giselda De Stefano, Alicia Navieckas, Silvana Cugliari, Pedro Negri Aranguren, Gabriela Balaguer, Maria Tosin, Guillermina Remaggi, Juan Altuve, Juan Jose Garcia, Luciana C. Ferrari, Graciela Klein, Luciana Guanchiale, Luis Beligoy, Mariana Marull, Maria Cecilia Dacunto, Marta Elisa Zerga, Nicolas Matias Kurgansky, Marcelo Pujol, Rossana L. Taus, Federico Sackman, Veronica Cintia Canosa, Soledad Cruset, Maximiliano Riddick, Astrid Pavlovsky
Journal: Blood (2017)
Long Noncoding RNA Discovery in Cardiovascular Disease
Authors: Tamer Sallam, Jaspreet Sandhu, Peter Tontonoz
Journal: Circulation Research (2018)

Despite significant improvements during the past 3 decades, cardiovascular disease remains a leading worldwide health epidemic. The recent identification of a fascinating group of mediators known as long noncoding RNAs (lncRNAs) has provided a wealth of new biology to explore for cardiovascular risk mitigation. lncRNAs are expressed in a highly context-specific fashion, and multiple lines of evidence implicated them in diverse biological processes. Indeed, abnormalities of lncRNAs have been directly linked with human ailments, including cardiovascular biology and disease. Of particular interest to the cardiovascular research community, dysregulation in lncRNA regulatory circuits have been associated with cardiac pathological hypertrophy, vascular disease, cell fate programming and development, atherosclerosis, dyslipidemia, and metabolic syndrome. Although techniques in interrogating noncoding RNAs are rapidly evolving, a major challenge in studying lncRNAs remains navigating through multiple technical constraints. In this review, we provide a road map for lncRNA discovery and interrogation in biological systems relevant to cardiovascular disease and highlight approaches to decipher their modes of action.
Harnessing Microfluidic Single Cell (MF-SC) and 3D Organ-on-Chip Assay Technologies for the Investigation of Immunotherapy and Study of Tumor Microenvironment (TME) in Antibody-Resistant Non-Hodgkin Lymphoma (NHL)
Authors: Ravi Dashnamoorthy, Saheli Sarkar, Pooja Sabachandani, Sneha Purvey, Afshin Beheshti, Tali Konry, Andrew M Evens
Journal: Blood (2017)
The pharma deals that CCGs fail to declare
Authors: Tom Moberly
Journal: BMJ (2018)

GP commissioning groups have accepted hundreds of payments from drug companies that they have not disclosed to patients and the public. Tom Moberly reports A BMJ investigation has uncovered the extent of payments from pharmaceutical companies to GP commissioning groups and the degree to which the deals are made public. Ever since clinical commissioning groups were launched in England in 2013, there have been concerns about the conflicts of interest among those who commission health services while also providing them.12 Now, to gain a full picture of the payments that private companies and charities are giving to CCGs, The BMJ has worked with Piotr Ozieranski, a lecturer in the department of social and policy sciences at the University of Bath, Shai Mulinari, a sociology researcher at Lund University in Sweden, and Emily Rickard, a research assistant in Bath’s department of social and policy sciences, who intend to publish the full findings of their research in the coming months. The BMJ received responses from all 207 CCGs in England after it made requests under freedom of information legislation about payments from private companies and charities. The data were compared with the details published by CCGs in their online public registries of declarations, which include payments from various sources (box 1). The responses to The BMJ ’s request showed that only two thirds of the 4600 payments—and just over a quarter of the value—that CCGs accepted from private companies and charities in 2015-16 and 2016-17 were listed in registers or declarations published by the CCGs. Box 1 ### Beyoncé tickets, sports matches, and VIP packages Details of the payments publicly declared by CCGs show the various ways in which other organisations interact with them. CCGs receive payments from charities and other private sector companies, such as consultancy firms and property investors, as well as from drug companies. For instance, in … RETURN TO TEXT
Variance between Experts and Oncology Healthcare Providers in Managing Polycythemia Vera and Myelofibrosis: Analysis of an Online Treatment Decision Support Tool
Authors: Ryan P Topping, Michael W. Deininger, John Mascarenhas, Ruben A Mesa, Brady Lee Stein, Kevin L Obholz, Jason J Everly, Srdan Verstovsek
Journal: Blood (2017)
Looking for a chronic care model in COPD patients
Authors: Enrico Clini, Ivana Castaniere, Roberto Tonelli
Journal: European Respiratory Journal (2018)

Chronic conditions demand "chronic" interventions intended for their holistic and thorough management, which is definitely embraced in the so-called chronic care model (CCM) [1]. In chronic obstructive pulmonary disease (COPD), an increasing body of evidence stresses the need for this patient-focused approach to care [2]. Since its first application, the chronic care method has needed to identify the ideal subset of patients that would largely benefit from its practice in real life and the most impactful areas of intervention. Recovery from hospitalisation following admission due to acute exacerbations is often recognised as the ideal time during which to educate the patient on how to react to health deterioration. Indeed, the transition from hospital back to the community represents a critical process, failure of which is associated with higher rates of rehospitalisation [3]. A chronic care model in primary care is feasible and effective for the COPD population even at an early stage <http://ow.ly/yZzR30gE26r>
Abstract 17005: In Women, but Not in Men, Angina is a Stronger Correlate of Myocardial Ischemia Induced by Psychological Than by Exercise/Pharmacological Stress
Authors: Viola Vaccarino, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Muhammad Hammadah, Naser Abdelhadi, Malik Obideen, Pratik Pimple, Oleksiy Levantsevych, Amit Shah, Ernest Garcia, Jonathon Nye, Michael Kutner, Laura Ward, J D Bremner, Paolo Raggi, David Sheps, Arshed Quyyumi
Journal: Circulation (2016)

Introduction: Mental stress-induced myocardial ischemia (MSIMI) is a common phenomenon in patients with coronary heart disease (CHD) and an emerging prognostic factor. Women with CHD tend to have m...
Regulatory T Cells Expanded Via TL1A-Ig Fusion Protein and Low Dose IL-2 Demonstrate Potent Suppression of Graft-Versus-Host Disease
Authors: Sabrina Copsel, Dietlinde Wolf, Brandon Kale, Henry Barreras, Casey O. Lightbourn, Cameron S. Bader, Krishna Komanduri, Robert B. Levy
Journal: Blood (2017)
Prognostic factors associated with survival and recurrence in resectable gastroesophageal adenocarcinoma: retrospective analysis of 497 patients operated at two Italian centers.
Authors: Michele Ghidini, Andrea Botticelli, Bianca Maria Donida, Lidia Strigari, Concetta Elisa Onesti, Margherita Ratti, Claudio Pizzo, Federico Aldighieri, Laura Toppo, Valerio Ranieri, Mario Occhipinti, Chiara Senti, Giulia Tanzi, Federica Mazzuca, Paolo Marchetti, Mario Martinotti, Rodolfo Passalacqua, Gianluca Tomasello, Massimo Rovatti
Journal: Journal of Clinical Oncology (2017)

e15588 Background: Chemotherapy (CT) and chemoradiotherapy (CTRT) both in neoadjuvant (neoadj) or adjuvant (adj) setting are associated with better overall survival (OS) over surgery alone in patients (pts) with resectable gastroesophageal (GE) adenocarcinoma (ADK). The best sequence and timing of treatments have still not been defined. A large cohort of GE ADKs derived from 2 high-volume Italian centers was analyzed to describe clinical outcomes and prognostic factors. Methods: 497 patients (pts) diagnosed with GE ADK who underwent surgery with curative intent from 2007 to 2016 were considered. Variables analyzed were: age, sex, tumor location, histology, T, N, M, R, G, HER-2, Helicobacter Pylori (HP) infection, (neo)adj CT, and adj CTRT. Analysis was performed according to ITT principle. Results: Median age at diagnosis was 71 years (range 35-92). At 26.7 months (mo) median follow-up, median OS was 27.6 mo (range 1-127) and median time to recurrence (TTR) 10.8 mo (range 7.8-13.1). Adj CT was administered in 203 cases (41%); 116 pts (23%) had adj CTRT and 47 (9%) neoadj CT. Statistically significant variables for OS and/or TTR at 12 months at univariate analysis were: age, T, N, M, R, G, adj CTRT, neoadj CT and adj CT. Results of multivariate analysis (MVA) are shown in Table 1. Conclusions: Despite a short follow-up, our analysis performed on a very large cohort of consecutive pts confirms the prognostic value of T and N for both OS and TTR. Adj CT and CTRT had a significant impact on 1 year OS, while neoadj CT gave only a 12 months TTR significant benefit. Based on these results, perioperative treatment strategies should always be considered in the management of resectable GE cancer. [Table: see text]
Cost-effectiveness of the Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults
Authors: Phuc Le, Michael B. Rothberg
Journal: JAMA Internal Medicine (2018)

The live attenuated herpes zoster vaccine (ZVL) is recommended for immunocompetent adults 60 years or older, but the efficacy wanes with age and over time. A new adjuvanted herpes zoster subunit vaccine (HZ/su) has higher efficacy but might be more expensive. The choice of vaccines depends on their relative values.To assess the cost-effectiveness of HZ/su.Markov decision model with transition probabilities based on the US medical literature. Participants were immunocompetent adults 60 years or older. Data were derived from participant groups ranging in number from less than 100 to more than 30 000 depending on the variable assessed. The study dates were July 1 to 31, 2017.No vaccination, ZVL (single dose), and HZ/su (2-dose series) vaccine administered at different ages.Total costs and quality-adjusted life-years (QALYs) were estimated.Based on randomized clinical trial data, at a price of $280 per series ($140 per dose), HZ/su was more effective and less expensive than ZVL at all ages. The incremental cost-effectiveness ratios compared with no vaccination ranged from $20 038 to $30 084 per QALY, depending on vaccination age. The finding was insensitive to variations in most model inputs other than the vaccine price and certain combinations of low adherence rate with a second dose and low efficacy of a single dose of HZ/su. At the current ZVL price ($213 per dose), HZ/su had lower overall costs than ZVL up to a price of $350 per 2-dose series. In probabilistic sensitivity analysis, HZ/su had 73% probability of being cost-effective for 60-year-olds at $50 000 per QALY.Under conservative assumptions, at a price of $280 per series ($140 per dose), HZ/su would cost less than ZVL and has a high probability of offering good value.
Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer
Authors: Daniel Dávila-González, Dong Soon Choi, Roberto R. Rosato, Sergio M. Granados-Principal, John G. Kuhn, Wen-Feng Li, Wei Qian, Wen Chen, Anthony J. Kozielski, Helen Wong, Bhuvanesh Dave, Jenny C. Chang
Journal: Clinical Cancer Research (2018)

Purpose: Chemoresistance in triple-negative breast cancer (TNBC) is associated with the activation of a survival mechanism orchestrated by the endoplasmic reticulum (EnR) stress response and by inducible nitric oxide synthase (iNOS). Our aim was to determine the effects of pharmacologic NOS inhibition on TNBC.Experimental Design: TNBC cell lines, SUM-159PT, MDA-MB-436, and MDA-MB-468, were treated with docetaxel and NOS inhibitor (L-NMMA) for 24, 48, and 72 hours. Apoptosis was assessed by flow cytometry using Annexin-V and propidium iodide. Western blot was used to assess ER stress and apoptosis, and rtPCR was used to evaluate s-XBP1. TNBC patient-derived xenografts (PDX) were treated either with vehicle, docetaxel, or combination therapy (NOS inhibition + docetaxel). Mouse weight and tumor volumes were recorded twice weekly. Docetaxel concentration was determined using mass spectrometry. To quantify proliferation and apoptosis, PDX tumor samples were stained using Ki67 and TUNEL assay.Results:In vitro, L-NMMA ameliorated the iNOS upregulation associated with docetaxel. Apoptosis increased when TNBC cells were treated with combination therapy. In TNBC PDXs, combination therapy significantly reduced tumor volume growth and increased survival proportions. In the BCM-5998 PDX model, intratumoral docetaxel concentration was higher in mice receiving combination therapy. Coupling docetaxel with NOS inhibition increased EnR-stress response via coactivation of ATF4 and CHOP, which triggered the pASK1/JNK proapoptotic pathway, promoting cleavage of caspases 3 and 9.Conclusions: iNOS is a critical target for docetaxel resistance in TNBC. Pharmacologic inhibition of NOS enhanced chemotherapy response in TNBC PDX models. Combination therapy may improve prognosis and prevent relapse in TNBC patients who have failed conventional chemotherapy. Clin Cancer Res; 24(5); 1152-62. ©2018 AACR.
Insights from human genetic studies of lung and organ fibrosis
Authors: Christine Kim Garcia
Journal: Journal of Clinical Investigation (2018)

Genetic investigations of fibrotic diseases, including those of late onset, often yield unanticipated insights into disease pathogenesis. This Review focuses on pathways underlying lung fibrosis that are generalizable to other organs. Herein, we discuss genetic variants subdivided into those that shorten telomeres, activate the DNA damage response, change resident protein expression or function, or affect organelle activity. Genetic studies provide a window into the downstream cascade of maladaptive responses and pathways that lead to tissue fibrosis. In addition, these studies reveal interactions between genetic variants, environmental factors, and age that influence the phenotypic spectrum of disease. The discovery of forces counterbalancing inherited risk alleles identifies potential therapeutic targets, thus providing hope for future prevention or reversal of fibrosis.