tbuckley/cabot-search huggingface dataset:
Fiber Intake and Survival After Colorectal Cancer Diagnosis
Authors: Mingyang Song, Kana Wu, Jeffrey A. Meyerhardt, Shuji Ogino, Molin Wang, Charles S. Fuchs, Edward L. Giovannucci, Andrew T. Chan
Journal: JAMA Oncology (2017)

<h3>Importance</h3> Although high dietary fiber intake has been associated with a lower risk of colorectal cancer (CRC), it remains unknown whether fiber benefits CRC survivors. <h3>Objective</h3> To assess the association of postdiagnostic fiber intake with mortality. <h3>Design, Setting, and Participants</h3> A total of 1575 health care professionals with stage I to III CRC were evaluated in 2 prospective cohorts, Nurses’ Health Study and Health Professionals Follow-up Study. Colorectal cancer–specific and overall mortality were determined after adjusting for other potential predictors for cancer survival. The study was conducted from December 23, 2016, to August 23, 2017. <h3>Exposures</h3> Consumption of total fiber and different sources of fiber and whole grains assessed by a validated food frequency questionnaire between 6 months and 4 years after CRC diagnosis. <h3>Main Outcomes and Measures</h3> Hazard ratios (HRs) and 95% CIs of CRC-specific and overall mortality after adjusting for other potential predictors for cancer survival. <h3>Results</h3> Of the 1575 participants, 963 (61.1%) were women; mean (SD) age was 68.6 (8.9) years. During a median of 8 years of follow-up, 773 deaths were documented, including 174 from CRC. High intake of total fiber after diagnosis was associated with lower mortality. The multivariable HR per each 5-g increment in intake per day was 0.78 (95% CI, 0.65-0.93;<i>P</i> = .006) for CRC-specific mortality and 0.86 (95% CI, 0.79-0.93;<i>P</i> &lt; .001) for all-cause mortality. Patients who increased their fiber intake after diagnosis from levels before diagnosis had a lower mortality, and each 5-g/d increase in intake was associated with 18% lower CRC-specific mortality (95% CI, 7%-28%;<i>P</i> = .002) and 14% lower all-cause mortality (95% CI, 8%-19%;<i>P</i> &lt; .001). According to the source of fiber, cereal fiber was associated with lower CRC-specific mortality (HR per 5-g/d increment, 0.67; 95% CI, 0.50-0.90;<i>P</i> = .007) and all-cause mortality (HR, 0.78; 95% CI, 0.68-0.90;<i>P</i> &lt; .001); vegetable fiber was associated with lower all-cause mortality (HR, 0.83; 95% CI, 0.72-0.96;<i>P</i> = .009) but not CRC-specific mortality (HR, 0.82; 95% CI, 0.60-1.13;<i>P</i> = .22); no association was found for fruit fiber. Whole grain intake was associated with lower CRC-specific mortality (HR per 20-g/d increment, 0.72; 95% CI, 0.59-0.88;<i>P</i> = .002), and this beneficial association was attenuated after adjusting for fiber intake (HR, 0.77; 95% CI, 0.62-0.96;<i>P</i> = .02). <h3>Conclusions and Relevance</h3> Higher fiber intake after the diagnosis of nonmetastatic CRC is associated with lower CRC-specific and overall mortality. Increasing fiber consumption after diagnosis may confer additional benefits to patients with CRC.
The Evolution of Procedural Competency in Internal Medicine Training
Authors: Chana A. Sacks, George A. Alba, Eli M. Miloslavsky
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Morbillo: situazione sub-ottimale in Francia
Authors: R Branchet, P Chauvin, A Flahault
Journal: Eurosurveillance (2000)

Il sistema informativo sentinella francese creato nel 1984 consiste di medici di base sparsi per tutto il paese, reclutati su base volontaria. Ogni settimana i membri di questa rete informativa riportano dati di sorveglianza epidemiologica su 10 indicatori di salute (sindrome simil-influenza, morbillo, varicella, parotite, epatite virale, diarrea acuta, tests HIV positivi, uretrite maschile, suicidio, e ricoveri ospedalieri). Le notifiche vengono raccolte per via telematica, Internet (http://www.b3e.jussieu.fr/sentiweb) o Minitel secondo le preferenze dei medici sentinella.
Surveillance for control of antimicrobial resistance
Authors: Evelina Tacconelli, Frangiscos Sifakis, Stephan Harbarth, Remco Schrijver, Maaike van Mourik, Andreas Voss, Mike Sharland, Nithya Babu Rajendran, Jesús Rodríguez-Baño, Julia Bielicki, Marlieke de Kraker, Sumanth Gandra, Petra Gastmeier, Kim Gilchrist, Achilleas Gikas, Beryl Primrose Gladstone, Herman Goossens, Hasan Jafri, Gunnar Kahlmeter, Frank Leus, Christine Luxemburger, Surbhi Malhotra-Kumar, Giuseppe Marasca, Michael McCarthy, María Dolores Navarro, María Nuñez-Nuñez, Abdel Oualim, Jessica Price, Jérôme Robert, Harriet Sommer, Maja von Cube, Cuong Vuong, Irith Wiegand, Anne Therese Witschi, Martin Wolkewitz
Journal: The Lancet Infectious Diseases (2017)
CBX8 Exhibits Oncogenic Activity via AKT/β-Catenin Activation in Hepatocellular Carcinoma
Authors: Chris Zhiyi Zhang, Shi-Lu Chen, Chun-Hua Wang, Yang-Fan He, Xia Yang, Dan Xie, Jing-Ping Yun
Journal: Cancer Research (2017)

Abstract Deregulation of polycomb proteins influences the development and progression of hepatocellular carcinoma. Here we show that chromobox 8 (CBX8) expression is increased in hepatocellular carcinoma and correlates with poor outcome in two independent cohorts containing a total of 879 cases. Ectopic expression of CBX8 facilitated tumor growth and metastasis, whereas CBX8 silencing suppressed these effects. CBX8 efficiently activated AKT/β-catenin signaling via upregulation of the transcription factor EGR1 and miR-365-3p in a noncanonical manner: CBX8 directly bound the EGR1 promoter to enhance its activity. In the nucleus, CBX8 also interacted with EGR1 to prevent its degradation. Furthermore, CBX8 increased the transcription of miR-365a-3p, which promoted the nuclear localization of β-catenin by targeting the 3′-UTR ZNRF1. Inhibiting either EGR1 or miR-365a-3p partially rescued CBX8-mediated malignant phenotypes. In clinical samples, CBX8 expression closely correlated with EGR1, miR-365a-3p, and nuclear β-catenin. Collectively, our results show that CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/β-catenin pathway. This newly identified signaling axis may suggest new therapeutic strategies against hepatocellular carcinoma. Significance: Elucidation of a key new element of the β-catenin signaling pathway in liver cancer may suggest new therapeutic targets. Cancer Res; 78(1); 51–63. ©2017 AACR.
Resistência bacteriana aos antibióticos em França : uma prioridade de saúde pública
Authors: H Aubry Damon, J Carlet, P Courvalin, J C Desenclos, J Drucker, D Guillemot, V Jarlier, B Régnier, B Schlemmer
Journal: Eurosurveillance (2000)

Durante alguns anos, a Franca foi confrontada com uma disseminacao rapida da resistencia aos antibioticos em hospitais e na clinica geral, apesar das varias recomendacoes emitidas para resolver este problema. Em 1999, o Institut de Veille Sanitaire (Instituto de Saude Publica) efectuou uma experiencia colectiva seguida por uma consulta nacional que reuniu todos os profissionais de saude envolvidos na resistencia aos antibioticos. Esta consulta foi concluida com a elaboracao de propostas na perspectiva de um plano nacional de accoes para controlar a resistencia aos antibioticos, apresentadas ao Ministerio da Saude frances.
Surto de shigelose numa instituição para crianças em Queluz, Portugal - 1995
Authors: A Suspiro, L Menezes
Journal: Eurosurveillance (1996)

A ocorrencia de infeccao a shigela numa instituicao para criancas, acarreta um elevado risco de, secundariamente, se disseminar pessoa a pessoa, dentro da instituicao(1). Neste artigo reporta-se um surto de shigelose, ocorrido no inicio de 1995, numa instituicao destinada a ocupacao dos tempos livres de criancas ate aos 10 anos de idade, que afectou 99 criancas, 17 familiares e 7 trabalhadores. A Autoridade de Saude encerrou o estabelecimento durante 5 dias para controlo da situacao, ao mesmo tempo que todas as familias em risco foram contactadas, no sentido de se administrar o antibiotico mais adequado a todos os afectados.
A long non-coding RNA HOTTIP expression is associated with disease progression and predicts outcome in small cell lung cancer patients
Authors: Yanqin Sun, Yuanyuan Zhou, Yifeng Bai, Qiongyao Wang, Jiarong Bao, Yingshan Luo, Ying Guo, Linlang Guo
Journal: Molecular Cancer (2017)

Despite progress in treatment of small cell lung cancer (SCLC), the biology of the tumor still remains poorly understood. Recently, we globally investigated the contributions of lncRNA in SCLC with a special focus on sponge regulatory network. Here we report lncRNA HOTTIP, which is specifically amplified in SCLC, is associated with SCLC proliferation and poor prognosis of patients. RT-qPCR was used to investigate the expression of HOTTIP in SCLC tissues and cell lines. The role of HOTTIP in SCLC cell proliferation was demonstrated by CCK8 assay, colony formation assay, flow cytometry analysis and in vivo SCLC xenograft model in nude mice through HOTTIP loss- and gain-of-function effects. Western blot assay was used to evaluate gene expression in cell lines at protein level. RNA pull-down, Mass spectrometry and RNA binding protein immunoprecipitation (RIP) were performed to confirm the molecular mechanism of HOTTIP involved in SCLC progression. We found that HOTTIP was overexpressed in SCLC tissues, and its expression was correlated with the clinical stage and the shorter survival time of SCLC patients. Moreover, HOTTIP knockdown could impair cell proliferation, affect the cell cycle and inhibit tumor growth of mice, while HOTTIP overexpression might enhance cell proliferation and cell cycle in vitro and in vivo. Mechanistic investigations showed that HOTTIP functions as an oncogene in SCLC progression by sponging miR-574-5p and affecting the expression of polycomb group protein EZH1. Overall, we identified that HOTTIP was involved in SCLC tumorigenesis through the ceRNA network "HOTTIP/miR-574-5p/EZH1". Our findings not only illuminate how HOTTIP confers an oncogenic function in SCLC pathogenesis, but also underscore a novel gene expression governing hallmarks in the disease.
Changes in Insurance Coverage Among Cancer Patients Under the Affordable Care Act
Authors: Aparna Soni, Lindsay M. Sabik, Kosali Simon, Benjamin D. Sommers
Journal: JAMA Oncology (2017)

Changes in Insurance Coverage Among Cancer Patients Under the Affordable Care ActThe Affordable Care Act (ACA) has reduced the number of uninsured persons in the United States to a historic low.Debate continues about potential changes to the law that could affect coverage for millions, particularly those with preexisting conditions.Meanwhile, cancer is the leading cause of death among Americans aged 19 to 64 years. 1 Treatment is often unaffordable for uninsured patients, 2 and some studies suggest that expanding insurance coverage could improve cancer-related outcomes. 3 Our objective was to quantify changes in health insurance coverage under the ACA among patients newly diagnosed with cancer.
Evidence of reduced recombination rate in human regulatory domains
Authors: Yaping Liu, Abhishek Sarkar, Pouya Kheradpour, Jason Ernst, Manolis Kellis
Journal: Genome biology (2017)

Recombination rate is non-uniformly distributed across the human genome. The variation of recombination rate at both fine and large scales cannot be fully explained by DNA sequences alone. Epigenetic factors, particularly DNA methylation, have recently been proposed to influence the variation in recombination rate. We study the relationship between recombination rate and gene regulatory domains, defined by a gene and its linked control elements. We define these links using expression quantitative trait loci (eQTLs), methylation quantitative trait loci (meQTLs), chromatin conformation from publicly available datasets (Hi-C and ChIA-PET), and correlated activity links that we infer across cell types. Each link type shows a "recombination rate valley" of significantly reduced recombination rate compared to matched control regions. This recombination rate valley is most pronounced for gene regulatory domains of early embryonic development genes, housekeeping genes, and constitutive regulatory elements, which are known to show increased evolutionary constraint across species. Recombination rate valleys show increased DNA methylation, reduced doublestranded break initiation, and increased repair efficiency, specifically in the lineage leading to the germ line. Moreover, by using only the overlap of functional links and DNA methylation in germ cells, we are able to predict the recombination rate with high accuracy. Our results suggest the existence of a recombination rate valley at regulatory domains and provide a potential molecular mechanism to interpret the interplay between genetic and epigenetic variations.
Theranostic Role of <sup>32</sup>P-ATP as Radiopharmaceutical for the Induction of Massive Cell Death within Avascular Tumor Core
Authors: Mirco Galiè, Federico Boschi, Ilaria Scambi, Flavia Merigo, Pasquina Marzola, Luisa Altabella, Umberto Lavagnolo, Andrea Sbarbati, Antonello E Spinelli
Journal: Theranostics (2017)

Drug inaccessibility to vast areas of the tumor parenchyma is amongst the major hurdles for conventional therapies.Treatment efficacy rapidly decreases with distance from vessels and most of the tumor cells survive therapy.Also, between subsequent cycles of treatment, spared cancer cells replace those killed near the vessels, improving their access to nutrients, boosting their proliferation rate, and thus enabling tumor repopulation.Because of their property of "acting at a distance," radioisotopes are believed to overcome the physical barrier of vascular inaccessibility.Methods A novel molecular imaging tool called Cerenkov Luminescence Imaging (CLI) was employed for the detection of Cerenkov radiation emitted by beta particles, allowing in vivo tracking of beta-emitters.More precisely we investigated using a xenograft model of colon carcinoma the potential use of 32P-ATP as a novel theranostic radiopharmaceutical for tracing tumor lesions while simultaneously hampering their growth.Results Our analyses demonstrated that 32P-ATP injected into tumor-bearing mice reaches tumor lesions and persists for days and weeks within the tumor parenchyma.Also, the high-penetrating beta particles of 32P-ATP exert a "cross-fire" effect that induces massive cell death throughout the entire tumor parenchyma including core regions.Conclusion Our findings suggest 32P-ATP treatment as a potential approach to complement conventional therapies that fail to reach the tumor core and to prevent tumor repopulation.
Immunotoxin and paclitaxel synergy results from a decrease in shed target antigen levels in the extracellular space of tumors
Authors: Yujian Zhang, Laiman Xiang, Raffit Hassan, Ira Pastan
Journal: Cancer Research (2008)

2552  Background: Immunotoxins are chimeric proteins designed to kill cancer cells and are composed of an antibody fragment linked to a portion of a toxin. Immuotoxins have been shown to be very active in hematological malignancies but much less active in solid tumor (Nat Rev Cancer. 2006 Jul;6(7):559-65). To improve their therapeutic efficacy, we treated A431/K5 tumor xenografts with immunotoxin SS1P that targets mesothelin in combination with paclitaxel, cisplatin or cyclophosphamide and observed synergy with all these combinations.  Purpose: To investigate the mechanism of synergy.  Experimental Design: To determine if chemotherapy sensitivity is required for synergy we compared a pair of paclitaxel-sensitive and paclitaxel-resistant KB tumors equally sensitive to immunotoxins SS1P and HB21(Fv)PE40 (targets transferrin receptor). Combinations of paclitaxel with SS1P or paclitaxel with HB21(Fv)PE40 were tested.  Because both mesothelin and transferrin receptor are known to be shed into the blood, we measured their concentrations within tumors and in the blood as a function of tumor size using nylon mesh basket method (Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H416-24). We also measured the effect of paclitaxel treatment on levels of soluble mesothelin and transferrin receptor in tumor ECF and serum by ELISA.  Results: The combination of paclitaxel and immunotoxin was synergistic producing long-lasting remissions on KB tumors with either of the immunotoxins (P
TCT-838 Prognostic Significance of a Previous Family History of Premature Coronary Artery Disease in Patients with Left Main Disease Undergoing PCI or CABG: Subgroup Analysis from EXCEL Trial
Authors: Matias Yudi, Roxana Mehran, Usman Baber, Aaron Crowley, Ori Ben-Yehuda, Emanuele Barbato, Bernard Stockman, Joseph Sabik, Patrick Serruys, A. Pieter Kappetein, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Feasibility study of nivolumab and docetaxel in previously treated patients with advanced non-small cell lung cancer
Authors: Kazuhito Miyazaki, Shunichiro Iwasawa, Yukiko Nakamura, Tsuneo Shimokawa, Takeharu Yamanaka, Yuichi Takiguchi, Hiroaki Okamoto
Journal: Annals of Oncology (2017)
Brote de gastroenteritis por salmonella entre los asistentes a la fiesta de inauguración de un restaurante en Grecia, junio de 1998
Authors: C Hadjichristodoulou, E Nikolakopoulou, K Karabinis, E Karakou, A Markogiannakis, C Panoulis, M Lampiri, P Tassios
Journal: Eurosurveillance (1999)

Hasta hace poco tiempo, el sistema de declaracion de enfermedades infecciosas en Grecia resultaba inadecuado, pero en 1998 se adopto un nuevo sistema de declaracion implicando una notificacion semanal de laboratorios colaboradores de todo el pais -con la ayuda de formularios estandar, enviados bien por e-mail o por fax-. Regularmente se declaran tanto el numero total de pruebas como los resultados positivos de ciertas enfermedades transmisibles seleccionadas. En 1997, solo se notificaron 326 casos de infeccion por salmonella al Ministerio de Sanidad mientras que, con el nuevo sistema de notificacion de los laboratorios, en tan solo 15 semanas de 1998 se declararon 662 casos de infeccion por salmonella.
TCT-304 Impact of predilation before TAVI with five leading new-generation TAVI devices: early results from the RISPEVA Study
Authors: Arturo Giordano, Francesco Bedogni, Nicola Corcione, Stefano Messina, Paolo Ferraro, Gennaro Maresca, Luca Testa, Nedy Brambilla, Federico De Marco, Carlo Pierli, Giulio Stefanini, Giacomo Frati, Giuseppe Biondi-Zoccai
Journal: Journal of the American College of Cardiology (2017)
Single-nephron proteomes connect morphology and function in proteinuric kidney disease
Authors: Martin Höhne, Christian K. Frese, Florian Grahammer, Claudia Dafinger, Giuliano Ciarimboli, Linus Butt, Julia Binz, Matthias J. Hackl, Mahdieh Rahmatollahi, Martin Kann, Simon Schneider, Mehmet M. Altintas, Bernhard Schermer, Thomas Reinheckel, Heike Göbel, Jochen Reiser, Tobias B. Huber, Rafael Kramann, Tamina Seeger-Nukpezah, Max C. Liebau, Bodo B. Beck, Thomas Benzing, Andreas Beyer, Markus M. Rinschen
Journal: Kidney International (2018)
Mortality and Cerebrovascular Events After Heart Rhythm Disorder Management Procedures
Authors: Justin Z. Lee, Jayna Ling, Nancy N. Diehl, David O. Hodge, Deepak Padmanabhan, Ammar M. Killu, Malini Madhavan, Peter A. Noseworthy, Suraj Kapa, Christopher J. McLeod, Yong-Mei Cha, Abhishek J. Deshmukh, Komandoor Srivathsan, Fred M. Kusumoto, Win-Kuang Shen, Paul A. Friedman, Thomas M. Munger, Samuel J. Asirvatham, Douglas L. Packer, Siva K. Mulpuru
Journal: Circulation (2017)

Recognition of rates and causes of hard, patient-centered outcomes of death and cerebrovascular events (CVEs) after heart rhythm disorder management (HRDM) procedures is an essential step for the development of quality improvement programs in electrophysiology laboratories. Our primary aim was to assess and characterize death and CVEs (stroke or transient ischemic attack) after HRDM procedures over a 17-year period.We performed a retrospective cohort study of all patients undergoing HRDM procedures between January 2000 and November 2016 at the Mayo Clinic. Patients from all 3 tertiary academic centers (Rochester, Phoenix, and Jacksonville) were included in the study. All in-hospital deaths and CVEs after HRDM procedures were identified and were further characterized as directly or indirectly related to the HRDM procedure. Subgroup analysis of death and CVE rates was performed for ablation, device implantation, electrophysiology study, lead extraction, and defibrillation threshold testing procedures.A total of 48 913 patients (age, 65.7±6.6 years; 64% male) who underwent a total of 62 065 HRDM procedures were included in the study. The overall mortality and CVE rates in the cohort were 0.36% (95% confidence interval [CI], 0.31-0.42) and 0.12% (95% CI, 0.09-0.16), respectively. Patients undergoing lead extraction had the highest overall mortality rate at 1.9% (95% CI, 1.34-2.61) and CVE rate at 0.62% (95% CI, 0.32-1.07). Among patients undergoing HRDM procedures, 48% of deaths directly related to the HDRM procedure were among patients undergoing device implantation procedures. Overall, cardiac tamponade was the most frequent direct cause of death (40%), and infection was the most common indirect cause of death (29%). The overall 30-day mortality rate was 0.76%, with the highest being in lead extraction procedures (3.08%), followed by device implantation procedures (0.94%).Half of the deaths directly related to an HRDM procedure were among the patients undergoing device implantation procedures, with cardiac tamponade being the most common cause of death. This highlights the importance of the development of protocols for the quick identification and management of cardiac tamponade even in procedures typically believed to be lower risk such as device implantation.
TCT-814 Results of left main percutaneous coronary intervention in diabetic patients at a long-term follow-up
Authors: Jesus Piqueras-Flores, Ignacio Sanchez-Perez, Alfonso Jurado-Román, María Thiscal López Lluva, Natalia Pinilla-Echeverri, Ramón Maseda Uriza, Manuel Marina-Breysse, Fernando Lozano
Journal: Journal of the American College of Cardiology (2017)
Abstract 19403: Abnormal Conduction is Predictive of a Higher Risk of Ventricular Arrhythmias in Myotonic Dystrophy Patients
Authors: Quocan Nguyen, Matthew Zipse, William H Sauer, Wendy Tzou, Joseph Schuller, Ryan Aleong
Journal: Circulation (2016)

Introduction: Permanent pacing is often indicated in myotonic dystrophy (MD) patients due to a high risk of conduction disease; however, the risk factors for ventricular arrhythmias (VA) and indica...