tbuckley/cabot-search huggingface dataset:
Abstract P1-03-12: A simulation study depicting the inconsistency of adjuvant online compared to genomic testing when determining the benefit of chemotherapy
Authors: S Khawaja, D Thomas, S Udayasankar, A Munir, A Huws, Y Sharaiha, S Holt
Journal: Cancer Research (2017)

Abstract Background: Prognostic factors have been used for years to determine the benefit of adjuvant chemotherapy in breast cancer. However, reporting of the size and grade of the tumor are affected by interobserver variability in reporting. This can result in a change in the results of adjuvant online and an impact on decision making of chemotherapy. On the contrary, genomic testing such as oncotype Dx is reproducible. The purpose of our study was to assess the effect of pathological discordance on the adjuvant online results on a cohort of patients who also underwent oncotype Dx testing. Materials and Methods: A total of 143 patients' histologies were included in this study. The results of the Phase III WSG-Plan B trial concerning central vs. local grade discrepancy rates were utilized to randomly change the grade of the tumors. 61 percent of grade 1 cancers were upgraded to grade 2 and 2% upgraded to grade 3. 4 percent of grade 2 cancers were downgraded to grade 1 and 26% were upgraded to grade 3. 1 percent of grade 3 cancers were downgraded to grade 1 and 25% were downgraded to grade 2. Likewise, change was made in the size of the tumor in 20 percent of patients. 8 to 10mm, 18-20, 28-30, and 48-50mm changed to 11, 21, 31 and 51mm respectively. 11-13mm, 21-23, 31-33, and 51-53mm was changed to 10, 20, 30, and 50mm. Ten percent of patients had the ER and Her 2 status changed. Results: The simulation results showed that when the grade was only altered, the spearman correlation of the predicted 10 year mortality on adjuvant online with the original data was significantly changed from 1 to a result of 0.788. When the changed size was additionally added, the coefficient was 0.836. With the altered ER status, the result was 0.749 and with the Her 2 change, the spearman correlation was minimally changed to 0.742. The scattergrams showed a large number of outliers when the alteration in size was added to the altered grade. Conclusion: Our simulation study confirms that with minimal changes in the clinical parameters because of the lack of perfect correlation between pathologist's results, there is a significant difference in the 10 year predicted mortality on adjuvant online. This is one step further in understanding the lack of correlation between adjuvant online and oncotype Dx, and the inconsistency of chemotherapy decision making with the sole use of adjuvant online. Citation Format: Khawaja S, Thomas D, Udayasankar S, Munir A, Huws A, Sharaiha Y, Holt S. A simulation study depicting the inconsistency of adjuvant online compared to genomic testing when determining the benefit of chemotherapy [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P1-03-12.
The correlations between EGFR mutations and TNM stages in patients with non-small cell lung cancer.
Authors: Laiyu Liu, Min Chen, Jian Guan, Lu Li, Mi Yang, Nanjie Xiao, Yue Zhang, Qinyang Li, Yongmei Dai, Chi Zhang, Longhua Chen
Journal: Journal of Clinical Oncology (2015)

e19121 Background: Epidermal growth factor receptor (EGFR) mutation status is one of the most critical factors for clinicians to develop multiple strategies in non-small cell lung cancer (NSCLC) patients. Whether EGFR mutations associated with more aggressive clinical characteristic is still uncertain. Here we conducted a retrospective study to outline the correlation of EGFR mutations with TNM stages. Methods: 754 Chinese patients diagnosed with NSCLC who underwent EGFR-mutant detections and comprehensively radiographic evaluations at initial diagnosis were consecutively enrolled at the Nanfang Hospital between 2010 and 2014. The imaging findings of chest, abdomen, brain, bone had been evaluated. EGFR-mutant rates were compared according to different TNM stages (AJCC 8th) and organs of metastasis. Results: EGFR mutation was found significantly more frequent in women, adenocarcinomas and never smokers. Patients with distant metastases (M1) were associated with EGFR mutations (46.1% [M1] versus 30.7% [M0], P＜0.001). In addition, the EGFR mutations were more frequent in patients with contralateral lung (47.9% versus 36.9%, P = 0.023), brain (51.1% versus 36.8%, P = 0.008), bone (48.8% versus 34.7%, P＜0.001) and pleural metastases (50.0% versus 36.7%, P = 0.009) than non-metastases in relative organs. For non-metastases, patients with EGFR mutation were more frequent in stages I-II than stage III (38.1% versus 21.7%, P = 0.001). More specifically, non-metastases with EGFR mutations were more frequent in T1-T2 than the stages of T3-T4 (34.3% versus 18.8%, P = 0.007) and N0-N1 than N2-N3 (35.7% versus 22.7%, P = 0.009). Conclusions: We found EGFR mutations were more frequent in metastatic disease and associated with the risk of metastases in bone, contralateral lung, brain, and pleural. Additionally, EGFR mutations correlated with earlier TNM stages in non-metastasis NSCLC patients.
High Major Response Rate, Including Very Good Partial Responses (VGPR), in Patients (pts) with Waldenstrom Macroglobulinemia (WM) Treated with the Highly Specific BTK Inhibitor Bgb-3111: Expansion Phase Results from an Ongoing Phase I Study
Authors: Constantine S. Tam, Judith Trotman, Stephen Opat, Paula Marlton, Gavin Cull, David Simpson, Matthew Ku, David Ritchie, Emma Verner, Sumita Ratnasingam, Mary Ann Anderson, Peter Wood, Mark Kirschbaum, Lai Wang, Ling Xue, Jianxin Yang, Eric Hedrick, John F Seymour, Andrew W. Roberts
Journal: Blood (2016)
Why do workload spikes cause injuries, and which athletes are at higher risk? Mediators and moderators in workload–injury investigations
Authors: Johann Windt, Bruno D Zumbo, Ben Sporer, Kerry MacDonald, Tim J Gabbett
Journal: British Journal of Sports Medicine (2017)

Spikes in training and competition workloads, especially in undertrained athletes, increase injury risk.1 However, just as attributing athletic injuries to single risk factors is an oversimplification of the injury process,2 3 interpreting this workload-injury relationship should not be done in isolation. Instead, we must further unpack how (ie, through which mechanisms) workload spikes might result in injury, and what characteristics make athletes more robust or more susceptible to injury at any given workload. In other words, which factors mediate the workload-injury relationship, and which moderate the relationship.

Like dominoes being knocked over, mediators can be viewed as the intermediary steps that explain the association between an observed variable and an outcome.4 In this context, mediating variables help to explain ‘why changes in workloads might cause injuries?’ For example, it is known that rugby league players exposed to spikes in running workloads, indicated by a high acute:chronic workload ratio, are at an increased risk for non-contact injuries.5 One potential explanation is that neuromuscular fatigue mediates this relationship, such that increased …
Systemic AAV-Mediated β-Sarcoglycan Delivery Targeting Cardiac and Skeletal Muscle Ameliorates Histological and Functional Deficits in LGMD2E Mice
Authors: Eric R. Pozsgai, Danielle A. Griffin, Kristin N. Heller, Jerry R. Mendell, Louise R. Rodino-Klapac
Journal: Molecular Therapy (2017)

Limb-girdle muscular dystrophy type 2E (LGMD2E), resulting from mutations in β-sarcoglycan (SGCB), is a progressive dystrophy with deteriorating muscle function, respiratory failure, and cardiomyopathy in 50% or more of LGMD2E patients. SGCB knockout mice share many of the phenotypic deficiencies of LGMD2E patients. To investigate systemic SGCB gene transfer to treat skeletal and cardiac muscle deficits, we designed a self-complementary AAVrh74 vector containing a codon-optimized human SGCB transgene driven by a muscle-specific promoter. We delivered scAAV.MHCK7.hSGCB through the tail vein of SGCB-/- mice to provide a rationale for a clinical trial that would lead to clinically meaningful results. This led to 98.1% transgene expression across all muscles that was accompanied by improvements in histopathology. Serum creatine kinase (CK) levels were reduced following treatment by 85.5%. Diaphragm force production increased by 94.4%, kyphoscoliosis of the spine was significantly reduced by 48.1%, overall ambulation increased by 57%, and vertical rearing increased dramatically by 132% following treatment. Importantly, no adverse effects were seen in muscle of wild-type mice injected systemically with scAAV.hSGCB. In this well-defined model of LGMD2E, we have demonstrated the efficacy and safety of systemic scAAV.hSGCB delivery, and these findings have established a path for clinically beneficial AAV-mediated gene therapy for LGMD2E.
Loss of Heterozygosity (LOH) for HumACTBP2 (SE33) Is Detected in Philadelphia (Ph)-Positive and Ph-Negative Hematopoietic Cells of Some Patients with Ph-Positive CML.
Authors: Haifa K. Al-Ali, Jeanett Edelmann, Sabine Leiblein, Christel Mueller, Evelin Hennig, Martina Bless, Christina Franke, Dietger W. Niederwieser
Journal: Blood (2005)
A Correction to the Research Article Titled: "A Common Mutation in the Defensin <i>DEFB126</i> Causes Impaired Sperm Function and Subfertility" by T. L. Tollner, S. A. Venners, E. J. Hollox, A. I. Yudin, X. Liu, G. Tang, H. Xing, R. J. Kays, T. Lau, J. W. Overstreet, X. Xu, C. L. Bevins, Gary N. Cherr
Journal: Science Translational Medicine (2011)
Reply: Direct Detection of Circulating MicroRNAs Unveiled the Absence of MicroRNA-218-5p in Smoker Subjects
Authors: Griet Conickx, Pieter Mestdagh, Jo Vandesompele, Guy G. Brusselle, Ken R. Bracke
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

We thank Cione and Gallelli for their interest in our work concerning the role of in the pathogenesis of chronic obstructive pulmonary disease (COPD) (1).We agree that investigating the contribution of microRNA (miRNA) to the pathogenesis of COPD is an attractive field (2-4).For clarity, we did not investigate the miRNA profile in lung biopsies but in lung tissue specimens from lobectomy or lung transplantation.Down-regulation of miR-218-5p in lung tissue from smokers and patients with COPD was first detected in a screening cohort of 30 patients and subsequently validated in a validation cohort of 71 patients and in bronchial biopsies of 19 patients.To address the concern of Cione and Gallelli about drugs affecting miR-218-5p expression, only 6 of 30 patients in the screening cohort were using inhaled corticosteroids, and linear regression analysis could not demonstrate an effect of the treatment on the expression of miR-218-5p.For the quantification of miRNA expression in human lung tissue, we used the stem-loop reverse transcriptasequantitative polymerase chain reaction (RT-qPCR) method, as this approach has both high sensitivity and specificity (5, 6).Although we did not investigate the expression of miR-218-5p in blood, several studies reported miR-218 levels in plasma or serum, using RT-qPCR (7-9).We regret that Cione and Gallelli are not able to detect miR-218-5p levels in serum in their limited cohort of smokers.Because detection of miRNA levels is highly technology dependent, it is crucial to evaluate the sensitivity of the proposed nCounter Flex System (NanoString Technologies, Seattle, WA), a hybridization-based miRNA quantification platform (10).Recently, the performance of different miRNA quantification platforms has been extensively evaluated in the miRQC (microRNA Quality Control) study ( 6).In this study, the sensitivity of the individual platforms was investigated by evaluating the number of detected miRNAs in serum RNA samples.Detection rates in serum RNA were highly variable among platforms, with qPCR platforms displaying higher sensitivity compared with hybridization-based platforms.Although the nCounter Flex System was included in the miRQC study, NanoString did not profile the serum samples, so the detection specificity and sensitivity of this platform in serum could therefore not be assessed.Regarding the functional effect of miR-218-5p, in vitro and in vivo perturbation experiments demonstrated that a reduced expression of miR-218-5p likely contributes to cigarette smokeinduced inflammation (1), providing novel insights into the pathogenesis of COPD.
Analysis of Genomic Aberrations and Its Impact on Survival in Patients with Chronic Lymphocytic Leukemia (CLL) at the William Beaumont Hospital Cancer Center
Authors: Foluso Nelson Ogunleye, Mohammed Ibrahim, Leann Michelle Blankenship, Siddhartha Yadav, Tolulope Ifabiyi, Vonda Douglas, Mark Micale, Elisa Quiroz, Susanna S Gaikazian, Michael Stender, Marianne Terese Huben, Joseph Anderson, Ishmael Jaiyesimi
Journal: Blood (2016)
Aldehyde Dehydrogenase (ALDH) Activity in Fresh (Pre-Freezing) and Post-Thawing Leukapheresis and Cord Blood Collections.
Authors: Cesare Perotti, Gianluca Viarengo, Claudia Del Fante, Laura Bellotti, Cristina Parisi, Andrea Marchesi, Laura Salvaneschi
Journal: Blood (2005)
HDAC6 regulates IL-17 expression in T lymphocytes: implications for HDAC6-targeted therapies
Authors: Bing Yan, Yang Liu, Hong Bai, Miao Chen, Songbo Xie, Dengwen Li, Min Liu, Jun Zhou
Journal: Theranostics (2017)

The pro-inflammatory cytokine interleukin 17 (IL-17) is critically involved in immunity and inflammation. T-helper 17 and γδ T cells are the predominant sources of IL-17 in the immune system. However, the mechanisms by which the expression of IL-17 is regulated in T cells remain elusive. Here, we demonstrate that loss of histone deacetylase 6 (HDAC6) in mice does not affect the generation of CD4+ or CD8+ T cells, but stimulates the development of IL-17-producing γδ T cells. Our data further show that HDAC6 deficiency increases the production of IL-17 by Vγ4+ γδ T cells in the spleen and lymph nodes. Consistent with these observations, small-molecule inhibition of HDAC6 activity in γδ T cells promotes the expression of IL-17 in vitro. These data thus reveal that HDAC6 represses IL-17 production in T cells, providing novel insights into the role of HDAC6 in the immune system. These findings also have important implications for the clinical investigation of HDAC6-targeted therapies.
Expression of Vascular Endothelial Growth Factor (VEGF) Associated with Its Receptor (VEGFR) in Relation to Tissue Factor (TF) in Human Breast Cancer Tissue.
Authors: Marek Wojtukiewicz, Ewa Sierko, Lech Zimnoch, Philip Thorpe, Ralf A. Brekken, Walter Kisiel
Journal: Blood (2005)
High Expression of Neutrophil Elastase Predicts Improved Survival In Pediatric Acute Myeloid Leukemia: A Report From the Children's Oncology Group
Authors: Roland B. Walter, Chelsea J. Gudgeon, Rhonda E. Ries, Todd A. Alonzo, Robert B. Gerbing, Phoenix A. Ho, Alan S. Gamis, Susana C. Raimondi, Betsy A. Hirsch, Janet Franklin, Soheil Meshinchi
Journal: Blood (2010)
Potential of Oncocardiology—Reply
Authors: Hui-Ming Chang, Edward T. H. Yeh
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Abstract P2-05-22: Prognostic significance of nuclear factor kappa B in node-negative breast cancer is most pronounced in luminal B breast cancer
Authors: M Schmidt, K Madjar, A-S Heimes, M Battista, A Lebrecht, K Almsetdt, A Hasenburg, J Rahnenführer, JG Hengstler
Journal: Cancer Research (2017)

Abstract Background: The importance of the cellular as well as the humoral immune system is increasingly recognized in breast cancer. The transcription factor nuclear factor kappa B (NFKB1) plays an important role in immune cell development. We examined the prognostic significance of NFKB1 in node-negative breast cancer. Methods: Microarray based gene-expression data for NFKB1 (209239_at) were analysed in four previously published cohorts (Mainz, Rotterdam, Transbig, Yu) of node-negative breast cancer patients not treated with adjuvant therapy (n=824). A meta-analysis of previously published cohorts was performed using a random effects model. Intrinsic subtypes were determined using gene-expression data. Prognostic significance of NFKB1 for metastasis-free survival (MFS) was examined in the whole cohort, in estrogen receptor (ER) positive as well as ER negative patients, and in different intrinsic subtypes: luminal A, liminal B, basal-like, HER2-enriched (HER2-E), and normal-like. Independent prognostic relevance was analysed using multivariate Cox regression. Results: Higher RNA expression of NFKB1 was related to better MFS in a meta-analysis of the whole cohort (HR 0.48, 95% CI 0.34-0.67, P&amp;lt;0.0001). NFKB1 was significantly associated with MFS only in ER positive (HR 0.41, 95% CI 0.24−0.69, P=0.0008) but not in ER negative (HR 0.76, 95% CI 0.39−1.48, P=0.4245) patients. Regarding intrinsic subtypes, the prognostic significance of NFKB1 was most pronounced in luminal B breast cancer (HR 0.40, 95% CI 0.17−0.93, P=0.0338) as compared to luminal A (HR 0.67, 95% CI 0.16−2.73, P=0.5738), basal-like (HR 0.67, 95% CI 0.29−1.56), P=0.3484), HER2-E (HR 0.70, 95% CI 0.25−2.00, P=0.5083), and normal-like (HR 0.49, 95% CI 0.18−1.32, P=0.1579) breast cancer. However, NFKB1 failed to show independent prognostic significance (HR 0.72, 95% CI 0.42-1.24, P=0.235) in multivariate analysis. Only histological grade of differentiation (HR 2.06, 95% CI 1.27-3.35, P=0.003) and tumor size (HR 1.58, 95% CI 1.01-2.48, P=0.045), but neither age nor HER2 status nor hormone receptor status maintained an independent prognostic association with MFS. Conclusions: The transcription factor NFKB1 shows prognostic significance in node-negative breast cancer. Higher expression of NFKB1 is associated with improved outcome. The prognostic impact of NFKB1 differs between intrinsic subtypes and is most pronounced in luminal B breast cancer. Citation Format: Schmidt M, Madjar K, Heimes A-S, Battista M, Lebrecht A, Almsetdt K, Hasenburg A, Rahnenführer J, Hengstler JG. Prognostic significance of nuclear factor kappa B in node-negative breast cancer is most pronounced in luminal B breast cancer [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P2-05-22.
Zidovudine Blocks NF-κB activity in Vivo in Adult T-Cell Leukemia
Authors: Juan Carlos Ramos, Luis M. Diaz, Michele Manrique, Rosangela Lima, Ngoc L Toomey, Tianli Xia, Lisa Cabral, Toumy Guettouche, Carlos Brites, William J. Harrington
Journal: Blood (2008)
Phase I Study Combining Ibrutinib with Rituximab, Ifosfamide, Carboplatin, and Etoposide (R-ICE) in Patients with Relapsed or Primary Refractory Diffuse Large B-Cell Lymphoma (DLBCL): NCI-Cancer Therapeutics Evaluation Program (CTEP) #9588
Authors: Craig S. Sauter, Stephanie L. Verwys, Susan J. McCall, Shoshana T. Miller, Amanda I. Courtien, Heiko Schoder, Pamela Harris, Matthew J. Matasar, Anas Younes, Craig H. Moskowitz
Journal: Blood (2016)
Efficacy of 90 Y - Ibritumomab Tiuxetan in Relapsed or Refractory Primary Gastric Non Hodgkin Lymphoma
Authors: Anna Vanazzi, Pier Francesco Ferrucci, Chiara Maria Grana, Giancarlo Pruneri, Cristiano Crosta, Antonello Pinto, Marco Chinol, Liliana Calabrese, Giovanni Paganelli, Giovanni Martinelli
Journal: Blood (2008)
A Prospective Randomized Comparison of Cyclophosphamide Versus Fludarabine in Addition of Antithymocyte Globuline for Allogeneic Hematopoietic Cell Transplantation in Patients with Adult Severe Aplastic Anemia; Interim Analysis
Authors: Hawk Kim, Won-Sik Lee, Yeo-Kyeoung Kim, Young-Don Joo, Jinny Park, Chul Won Jung, Jae-Cheol Jo, Jung-Hee Lee, Je-Hwan Lee, Dae-Young Kim, Kyoo-Hyung Lee
Journal: Blood (2014)
Hypophysectomy in Advanced Breast Cancer
Authors: B. J. Kennedy, Lyle A. French, William T. Peyton
Journal: New England Journal of Medicine (1956)

THERE is undisputed evidence that the administration of steroid hormones or deprivation of hormone-producing tissues favorably modifies the anticipated behavior of advanced breast cancer. Extensive reviews have demonstrated the improvement that may be attained in selected patients after castration or adrenalectomy and the administration of estrogenic hormones, androgenic hormones or cortisone.1 , 2 These methods of therapy have significantly altered the course of breast cancer to the extent that the lives of some patients have definitely been prolonged. It is postulated that the favorable responses occurring during hormonal therapy are mediated in part by suppression of the pituitary gland.3 Recently, total surgical . . .
Abstract P6-12-12: Phase I study of the JAK 1/2 inhibitor ruxolitinib with weekly paclitaxel for the treatment of HER2 negative metastatic breast cancer (MBC)
Authors: B Overmoyer, M Regan, E Schlosnagle, C Bunnell, R Freedman, S Tolaney, W Chen, E Mayer, A Partridge, D Silver, E Winer
Journal: Cancer Research (2017)

Abstract This abstract was not presented at the symposium.
In patients with axial spondyloarthritis, inflammation on MRI of the spine is longitudinally related to disease activity only in men: 2 years of the axial spondyloarthritis DESIR cohort
Authors: Victoria Navarro-Compán, Sofia Ramiro, Robert Landewé, Maxime Dougados, Corinne Miceli-Richard, Pascal Richette, Désirée van der Heijde
Journal: Annals of the Rheumatic Diseases (2017)

The effects of inflammatory disease activity (DA) on radiographic progression in patients with axial spondyloarthritis (axSpA) are worse in men and smokers, but an explanation for this is lacking.1 Recently, we have found a relationship between inflammatory lesions in the sacroiliac joints (SIJs) detected by MRI and clinical DA measures in male patients, which was absent in female patients.2 Here, we investigate whether this gender-specific association between MRI-lesions and clinical DA extends to the spine.

The objectives of this study were: (i) to explore the relationship between inflammatory lesions of the spine on MRI and DA in patients with axSpA; (ii) to investigate if such a relationship is gender specific and (iii) to explore the influence of other patient-related factors on the relationship between MRI of the spine and DA.

Two-year follow-up data from 164 patients fulfilling Assessment of SpondyloArthritis international Society (ASAS) axSpA criteria in the DEvenir des Spondylarthopathies Indifferenciees Recentes (DESIR) cohort with at least two spine MRIs available during this period were analysed.3 ,4

The relationship between MRI-spine and DA (Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), patient’s global DA, night pain, C reactive protein (CRP) and erythrocyte sedimentation rate (ESR)) was analysed by generalised estimating equations (GEEs) on absolute MRI-spine scores (Berlin …