tbuckley/cabot-search huggingface dataset:
Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study
Authors: D. Gramatzki, P. Roth, E.J. Rushing, J. Weller, N. Andratschke, S. Hofer, D. Korol, L. Regli, A. Pangalu, M. Pless, J. Oberle, R. Bernays, H. Moch, S. Rohrmann, M. Weller
Journal: Annals of Oncology (2018)

BackgroundThe vascular endothelial growth factor antibody bevacizumab (Avastin®), received approval for the treatment of recurrent glioblastoma in many countries including the USA and Switzerland, but not the European Union, in 2009. Here, we explored the hypothesis that the approval of bevacizumab improved outcome with glioblastoma on a population level.Patients and methodsThe prognostic significance of epidemiological, molecular genetic, and clinical data including treatment for glioblastoma patients diagnosed from 2010 to 2014 in the Canton of Zurich, Switzerland, was retrospectively analyzed using log-rank test and Cox proportional hazards models. Data were compared with data for the years 2005–2009.ResultsIn total, 310 glioblastoma patients were identified in the years 2010–2014. Median overall survival was 13.5 months for patients with known isocitrate dehydrogenase (IDH) wild-type (wt) (IDH1R132H-non-mutant) tumors (N = 248), compared with 11.3 months for IDH wt patients (P = 0.761) before (2005-2009). In the IDH wt cohort, bevacizumab use at any time increased from 19% in 2005–2009 to 49% in 2010–2014. Multivariate analysis did not identify bevacizumab exposure at any time to be associated with survival. Yet, upon the second-line treatment, baseline doses of corticosteroids were reduced by more than half in 83% of patients on bevacizumab compared with 48% of the patients treated with bevacizumab-free regimens (P = 0.007).ConclusionThis epidemiological study of a small, but clinically well-annotated patient cohort fails to support the assumption that the strong increase of bevacizumab use since 2010 improved survival in glioblastoma although clinical benefit associated with decreased steroid use may have been achieved.
Capsule endoscopy and deep enteroscopy
Authors: Enrique Pérez-Cuadrado Martínez, Enrique Pérez-Cuadrado Robles
Journal: Endoscopy (2014)

During the 2014 Digestive Disease Week in Chicago, many high-quality studies on small-bowel endoscopy were presented. The most relevant abstracts from around the world of two complementary procedures - capsule endoscopy and deep enteroscopy - which have seen rapid changes in recent years, have been selected for this review.
Coloscopie double ballon (CDB): le moyen le plus efficace d'atteindre le caecum après une coloscopie incomplète
Authors: O Haidouri, M Delvaux, M Frederic, I Fassler, G Gay
Journal: Endoscopy (2011)

Introduction: La technique de progression utilisée pour l'entéroscopie double ballon s'est révélée utile pour la réalisation de coloscopies difficiles, notamment chez des patients multiopérés. Une étude initiale (Endoscopy 2007; 39: 788–792) avait montré l'intérêt d'utiliser un coloscope comparable à l'entéroscope double ballon (EC-450B15. Fujinon Optical Co. Ltd., Saitama, Japon) mais plus court et donc plus adapté aux procédures thérapeutiques. Le but de ce travail était d'évaluer l'intérêt de la CDB, en pratique quotidienne pour réaliser une coloscopie complète chez des patients non sélectionnés dont la coloscopie classique avait été incomplète en raison de difficultés de progression.
Prophylaxie secondaire de la rupture de varices oesophagiennes. Expérience algéroise
Authors: N Afredj, N Debzi, A Nani, N Guessab, T Boucekkine
Journal: Endoscopy (2009)

Introduction: Les objectifs de notre travail sont d'évaluer l'efficacité de la ligature élastique (LE) dans: l'éradication des varices oesophagiennes (VO); la prévention de la récidive hémorragique et d'évaluer les complications de la LE.
INTRAOPERATIVE COMPLICATIONS OF PERORAL ENDOSCOPIC MYOTOMY (POEM)
Authors: M Korolev, L Fedotov, A Ogloblin, S Mamedov, M Antipova, A Klimov, R Avanesyan, A Smirnov
Journal: Endoscopy (2018)

To show most frequent Intraoperative complications of Endoscopic Myotomy and methods of their correction.
ENDOSONOGRAPHIC PREDICTION OF HISTOPATHOLOGICAL SEVERITY AND DYSPLASIA IN ULCERATIVE COLITIS
Authors: A Elrabat, M Maher, F Abozeid
Journal: Endoscopy (2018)

Ulcerative colitis (UC) is one of the most common forms of IBD. Endoscopic ultrasound is a highly accurate diagnostic endoscopic and radiological modality for the assessment of rectal pathology by measuring colon wall thickness and the surrounding structure. The aim of this study is to evaluate the role of EUS in determination of severity of UC and its correlation with clinical, endoscopic and histopathological parameters.
ENDOSCOPIC FULL THICKNESS RESECTION IN THE RECTUM CLOSED WITH POLYLOOP AND CLIPS
Authors: H Uchima, L Torrealba, C Huertas, M Hombrados, M Figa, R Louvriex, S Arjona, X Aldeguer
Journal: Endoscopy (2018)

En bloc resection was finished and then a polyloop attached to a clip inserted through the single channel scope was introduced in parallel.
Ten-Year Progression of Myopic Maculopathy
Authors: Yan Ni Yan, Ya Xing Wang, Yan Yang, Liang Xu, Jie Xu, Qian Wang, Jing Yan Yang, Xuan Yang, Wen Jia Zhou, Kyoko Ohno-Matsui, Wen Bin Wei, Jost B. Jonas
Journal: Ophthalmology (2018)
Prime minister to bring forward “multiyear” funding boost for the NHS
Authors: Gareth Iacobucci
Journal: BMJ (2018)

Theresa May has indicated that she will bring forward a new “multiyear” funding settlement for the NHS ahead of next year’s government spending review to help ease immediate pressures on the service.

The comments, made to a House of Commons liaison committee on Tuesday 27 March,1 follow increasingly vociferous calls from MPs and healthcare leaders for an urgent funding injection to help stabilise overburdened services.

Earlier this week, the health secretary Jeremy Hunt said that the NHS needed a 10 year settlement to allow proper long term planning to cope with rising demand, and a cross party group of 91 MPs wrote to the prime minister urging her to examine the …
Preclinical Studies of Stem Cell Therapy for Heart Disease
Authors: Bryon A. Tompkins, Wayne Balkan, Johannes Winkler, Mariann Gyöngyösi, Georg Goliasch, Francisco Fernández-Avilés, Joshua M. Hare
Journal: Circulation Research (2018)

As part of the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the role of preclinical studies designed to advance stem cell therapies for cardiovascular disease. The quality of this research has improved over the past 10 to 15 years and overall indicates that cell therapy promotes cardiac repair. However, many issues remain, including inability to provide complete cardiac recovery. Recent studies question the need for intact cells suggesting that harnessing what the cells release is the solution. Our contribution describes important breakthroughs and current directions in a cell-based approach to alleviating cardiovascular disease.
ROLE OF A VOLTAGE-GATED CHLORIDE-CHANNEL GENE CLC-5 IN HUMAN AND RAT HYPERCALCIURIA
Authors: S J Scheinman, S E Lloyd, Pearce Shs., R R Hoppes, S E Fisher, I W Craig, T J Jentsch, D A Bushinsky, R V Thakker
Journal: Journal of the American Society of Nephrology (1995)
Abstract 456: Early Doxorubicin Exposure Upregulates P-STAT3 Expression in Adult Murine Model
Authors: Tanoya L Harris, Gregory J Aune
Journal: Circulation Research (2016)

Background: Anthracyclines such as doxorubicin (DOX) are a key component of chemotherapy treatments and also have cardiotoxic effects that can manifest decades after initial exposure. Long term survivors have a 15 times greater risk of heart failure than the general population. Previously, our lab has shown an increase in serum leptin in DOX treated animals 15 months after exposure. Altered p-STAT3 activation has been shown in patient and mouse models of heart failure and is downstream of leptin receptor activation. Our overall aim was to evaluate p- STAT3 levels in mice hearts of aged mice previously exposed to doxorubicin during development. Methods: C57/BL6J mice were injected weekly intraperitoneally with saline or 1 mg/kg, 3 mg/kg/ and 5mg/kg/ week of the DOX from 2 weeks to 6 weeks of age. At 7 weeks one cohort of mice were harvested. At 15 months a second cohort was harvested. Hearts were cut in half and one half paraffin sectioned. From the other half, heart lysates were prepared. P-STAT3 and STAT3 expression was evaluated by Immunohistochemistry and Western blots. Results and Conclusions: Western blot confirms a dose-dependent upregulation of p-STAT3 expression in DOX treated mice hearts at 80 weeks old compared to controls (1.13 VS. 0.04, p-STAT3/STAT3 ratio). In addition, p-STAT3 is increased by immunohistochemistry. This indicates that early exposure to DOX may produce changes in the heart that continue throughout life. These findings suggest that gene targets of activated p-STAT3 may drive the gradual progression to heart failure in patients exposed to anthracyclines during childhood. Future studies, may elucidate therapeutic targets to slow the progression of heart failure in these patients.
Analysis of Endoscopic Ultrasound Elastography used for Characterization of Benign and Malignant Lymph Nodes
Authors: A Saftoiu, P Vilmann, H Hassan, F Gorunescu
Journal: Endoscopy (2006)

Background: Ultrasound elastography is a new imaging procedure that allows the reconstruc-tion of elasticity distribution by characterizing the difference of hardness between diseased tissue and normal tissue. Aim: The aim of our study was to apply real-time elastography during EUS examinations and to consequently characterize benign versus malignant lymph nodes. The pattern of real-time EUS elas-tography images was compared with the conventional EUS aspects of lymph nodes and with the final diagnosis obtained by EUS-FNA cytology analysis and/or by surgical pathology. Results: Patients diagnosed by EUS with cervical, mediastinal or abdominal lymph nodes were prospectively included, with a total number of 42 lymph nodes examined by EUS elastography. By using a qualitative pattern analysis we were able to differentiate benign and malignant lymph nodes with a high sensitivity, specificity and accuracy (91.7%, 94.4% and 92.86%, respectively), based on five pre-defined patterns obtained on EUS elastography. A quantitative analysis based on histo-grams of the EUS elastography images also allowed an excellent discrimination between benign and malignant lymph nodes. Based on separate RGB channel histogram values, an “elasticity ratio“ was further defined and yielded a sensitivity, specificity and accuracy for the differential diagnosis of 95.8%, 94.4% and 95.2%, respectively, based on a cut-off level of 0.84. Conclusions: EUS elastography is a promising method that allows the characterization and dif-ferentiation of benign and malignant lymph nodes with a high sensitivity, specificity and accuracy, offering complementary information added to conventional EUS imaging.
ESOPHYX2.0 AND MUSE SYSTEMS FOR TRANSORAL INCISIONLESS FUNDOPLICATION (TIF) FOR TREATMENT OF GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD): 6- AND 12-MONTH RESULTS FROM A SINGLE-CENTER RETROSPECTIVE STUDY
Authors: PA Testoni, G Mazzoleni, G DiStefano, S Testoni, L Fanti, M Antonelli, S Passaretti
Journal: Endoscopy (2018)

EsophyX2.0 (EndoGastric Solutions) creates a 270 ° circumferential valve by deploying polypropylene fasteners under endoscopic vision. MUSE (Medigus Ultrasonic Surgical Endostapler) creates a fundoplication similar to Dor-Thal by using a surgical endostapler to place metal stitches under ultrasound-guide. Aim of the study: to retrospectively compare clinical, pathophysiological and endoscopic results at 6 and 12 months after TIF with the two systems.
Imaging activated T cells predicts response to cancer vaccines
Authors: Israt S. Alam, Aaron T. Mayer, Idit Sagiv-Barfi, Kezheng Wang, Ophir Vermesh, Debra K. Czerwinski, Emily M. Johnson, Michelle L. James, Ronald Levy, Sanjiv S. Gambhir
Journal: Journal of Clinical Investigation (2018)

In situ cancer vaccines are under active clinical investigation, given their reported ability to eradicate both local and disseminated malignancies. Intratumoral vaccine administration is thought to activate a T cell–mediated immune response, which begins in the treated tumor and cascades systemically. In this study, we describe a PET tracer (64Cu-DOTA-AbOX40) that enabled noninvasive and longitudinal imaging of OX40, a cell-surface marker of T cell activation. We report the spatiotemporal dynamics of T cell activation following in situ vaccination with CpG oligodeoxynucleotide in a dual tumor–bearing mouse model. We demonstrate that OX40 imaging was able to predict tumor responses on day 9 after treatment on the basis of tumor tracer uptake on day 2, with greater accuracy than both anatomical and blood-based measurements. These studies provide key insights into global T cell activation following local CpG treatment and indicate that 64Cu-DOTA-AbOX40 is a promising candidate for monitoring clinical cancer immunotherapy strategies.
RISK STRATIFICATION FOR THE TREATMENT OF GASTRIC VARICES SECONDARY TO PORTAL HYPERTENSION
Authors: Y Tseng, L Ma, S Chen
Journal: Endoscopy (2018)

Gastroesophageal variceal hemorrhage is a common complication associated with portal hypertension. Even with appropriate secondary prophylactic therapy the rate of variceal hemorrhage and its associated mortality remain concerning, especially in patients with gastric varices. Current guidelines provide well-established recommendations for esophageal varices, while that of gastric varices remain scarce and lack evidential strength. This study is aimed at identifying a feasible risk stratification method based on imaging findings to evaluate patient response to cyanoacrylate injection for the treatment of gastric varices.
Abstract MP69: How Well Do Cardiovascular Risk Factors Before and During Pregnancy Correlate? The International Childhood Cardiovascular Cohort (i3C) Consortium
Authors: Emily W Harville, Lydia Bazzano, Jessica Woo, Trudy Burns, Olli Raitakari, Elaine Urbina, Alison Venn, David Jacobs, Julia Steinberger, Alan Sinaiko, Terry Dwyer, Markus Juonala
Journal: Circulation (2018)

Background: Pregnancy complications such as gestational diabetes and pre-eclampsia predict later cardiovascular (CV) outcomes. However, it still is not clear whether pregnancy complications unmask preexisting impairments or instigate lasting injury. If pre-pregnancy and during-pregnancy CV risk factors are strongly correlated, it becomes more plausible that pregnancy unmasks an existing problem than creating a new one. Methods: Data from the i3C Consortium, a group of studies assessing the relationship between child/adolescent CV risk factors and adult outcomes, were used. 290 women from four cohorts had data on the same risk factor (blood pressure, lipids, glucose) from visits both prior to and during pregnancy. Correlation coefficients between the pre- and during pregnancy measures were calculated, and the mean difference between the measures modeled with adjustment for age, BMI, race, smoking, and study. Differences by gestational age and time between the pre-pregnancy visit and pregnancy visit were also examined. Results: All measures were strongly correlated at pre- and during-pregnancy visits (p&lt;0.01), with r of between 0.3 and 0.55. The exception was glucose (r=0.11, p=0.15). These relationships held after adjustment for confounders. Interactions with gestational age indicated stronger correlations with measurements taken in the first and second trimesters than the third. The correlation did not differ by the time elapsed between the pre-pregnancy and pregnancy visits. Conclusions: Pre- and during-pregnancy CV risk factors are moderately well correlated. It is likely that women who develop pregnancy complications enter the pregnancy with higher risk rather than pregnancy inducing new vascular effects.
Magnified endoscopic observation of small depressed gastric lesions using linked color imaging with indigo carmine dye
Authors: Yoshiyasu Kitagawa, Taro Hara, Dai Ikebe, Rino Nankinzan, Hideyuki Takashiro, Ryosuke Kobayashi, Kazuyoshi Nakamura, Taketo Yamaguchi, Takuto Suzuki
Journal: Endoscopy (2017)

Abstract Background and study aims Magnifying linked color imaging with indigo carmine dye (M-Chromo-LCI) enables sterically enhanced and color image-magnified observation of the superficial gastric mucosa. This study investigated the usefulness of M-Chromo-LCI for the differential diagnosis of gastric lesions. Patients and methods 100 consecutive small depressed lesions were examined with conventional white-light imaging (C-WLI), magnifying blue-laser imaging (M-BLI), and M-Chromo-LCI. Endoscopic images were reviewed by three experts and three non-experts. Diagnostic accuracy and interobserver agreement were compared among the modalities. Results For experts, M-BLI showed a significantly higher diagnostic accuracy than C-WLI (82.7 % vs. 67.0 %; P &lt; 0.001). The diagnostic accuracy of M-Chromo-LCI was not different from M-BLI (87.7 % vs. 82.7 %; P = 0.31). For non-experts, M-BLI showed a significantly higher diagnostic accuracy than C-WLI (69.3 % vs. 52.3 %; P &lt; 0.001). M-Chromo-LCI additionally showed a significantly higher diagnostic accuracy than M-BLI (79.7 % vs. 69.3 %; P = 0.005). M-Chromo-LCI had the highest interobserver agreement for each group. Conclusions: M-Chromo-LCI is expected to become a useful modality for the accurate diagnosis of gastric lesions.
Echoendoscope axial (prototype Olympus XGIF-UCT160J-AL5) pour le drainage des collections pancréatique: étude de faisabilité chez 16 malades
Authors: M Pioche, F Fumex, B Napoléon, C Lefort, T Ponchon
Journal: Endoscopy (2009)

Introduction: Le drainage endoscopique sous écho-endoscopie des collections pancréatiques est aujourd'hui bien admis. Les kystogastrostomies ou les kystoduodénostomies sont au mieux réalisées en un temps à l'aide d'un échoendoscope linéaire à vision latérale permettant la ponction du kyste et l'insertion de prothèses. Néanmoins l'abord tangentiel de la zone de ponction peut rendre la procédure difficile, notamment au moment d'insérer les prothèses. La société Olympus a développé un écho-endoscope (Olympus XGIF-UCT160J-AL5) à vision et canal opérateur axiaux afin de faciliter les manœuvres endoscopiques. Nous avons évalué la faisabilité du drainage des collections pancréatiques avec ce nouveau matériel.
New balloon-guided technique for deep small-intestine endoscopy using standard endoscopes
Authors: S. Adler, I. Bjarnason, Y. Metzger
Journal: Endoscopy (2008)

The advent of capsule endoscopy has opened the entire small bowel to direct inspection. The identification of pathology often requires diagnostic and therapeutic interventions. The available means today are push enteroscopy (limited to the proximal small bowel), intraoperative enteroscopy (invasive) and push-pull double-balloon enteroscopy (very effective but requires an expensive dedicated system). The aim of this study was to test the safety and efficacy of a novel push-pull technique, balloon-guided endoscopy (BGE), which can be used with standard endoscopic equipment.Twenty patients with various disorders of the small intestine were examined by BGE. Various endoscopes were used and insertion depth was measured as is customary in double-balloon enteroscopy, by adding together the length of all the insertions of the endoscope performed during the push-pull steps.In 17 peroral intubations of the small bowel the average insertion depth beyond the ligament of Treitz was 1.45 m; insertion depth ranged from 0.80 m to 2.65 m. BGE advancement was deeper than in published results for push enteroscopy, though not equaling those for double-balloon enteroscopy. In the three transanal procedures the ileocecal valve was traversed and the terminal ileum intubated. No severe adverse events occurred.BGE is safe. BGE enables deep intubation of the small bowel beyond the ligament of Treitz utilizing standard endoscopes. Insertion depth with this technique is beyond that achieved by push enteroscopy. Further studies are needed, and technical improvements will lead to deeper insertion.
Dominant influenza A(H3N2) and B/Yamagata virus circulation in EU/EEA, 2016/17 and 2017/18 seasons, respectively
Authors: Cornelia Adlhoch, René Snacken, Angeliki Melidou, Silviu Ionescu, Pasi Penttinen
Journal: Eurosurveillance (2018)

We use surveillance data to describe influenza A and B virus circulation over two consecutive seasons with excess all-cause mortality in Europe, especially in people aged 60 years and older. Influenza A(H3N2) virus dominated in 2016/17 and B/Yamagata in 2017/18. The latter season was prolonged with positivity rates above 50% among sentinel detections for at least 12 weeks. With a current west-east geographical spread, high influenza activity might still be expected in eastern Europe.
A RARE CAUSE OF RECURRENT PANCREATITIS TREATED BY ENDOSCOPIC DIVERTICULOTOMY
Authors: I Budimir, V Tomasic, N Barsic, D Kralj, D Hrabar, N Ljubicic, E Stajduhar, PH Deprez
Journal: Endoscopy (2018)

Intraluminal (“windsock”) diverticulum of the duodenum (IDD) is a rare congenital anomaly associated with incomplete duodenal luminal formation during embryonic development that clinically manifests in adulthood (usually in the fourth decade of life). Main symptoms are partial or complete obstruction of the duodenal lumen, and the most common complications are bleeding, acute or recurrent pancreatitis, acute cholangitis or intestinal intussusception.
NON-NEOPLASTIC FINDINGS IN PARTICIPANTS OF COLORECTAL SCREENING PROGRAMME
Authors: GH Bautista, MA Jimenez Moreno, RP Garcia, J Sanz Sanchez, BB Cabredo, AM Urdaneta, EB Aranda, BS Aladren, S Garcia Moran, JL Martin Lorente, F Saez-Royuela Gonzalo
Journal: Endoscopy (2018)

Screening programme for CRC was introduced in our hospital in october 2014. We collected data until april 2017. Men and women between 50 and 69 years old were invited to undergo a Faecal Immunochemical Test (FIT). Those who obtained a positive result were offered to perform a colonoscopy.
Evaluation rétrospective de la faisabilité et de l'efficacité des drainages biliaires guidés par échoendoscopie: A propos de 49 procédures consécutives
Authors: E Bories, C Pesenti, F Caillol, M Giovannini
Journal: Endoscopy (2009)

Introduction: L'échoendoscopie (EE) interventionnelle a été récemment intégrée cedans l'organigramme de traitement des ictères obstructifs. Le but de ce travail était d'évaluer rétrospectivement notre expérience.
Rapport coût-efficacité de la coloscopie virtuelle de dépistage en population avec et sans seuil de la taille du polype de 6mm pour polypectomie
Authors: D Heresbach, P Chauvin, A Hess-Migliorretti, J Grolier, F Riou, JM Josselin
Journal: Endoscopy (2009)

Introduction: La coloscopie virtuelle (CTC) possède une précision diagnostique acceptable pour la détection des polypes et néoplasies coliques comparée à la vidéocoloscopie en particulier pour les polypes ≥6mm. Son utilisation en stratégie de dépistage en population recommandée aux USA est encore en Europe au stade préliminaire et nécessite, des études médico-économiques préalables avant à sa diffusion.