tbuckley/cabot-search huggingface dataset:
Evaluation du traitementendoscopique des ulcères hémorragiques dans un centre: expérience sur 7 ans
Authors: R Bouali, F Khedirii
Journal: Endoscopy (2004)

Objectif: Evaluer la faisabilité et l’efficacité du traitement endoscopique dans les ulcères hémorragiques gastro duodénaux. Dégager les facteurs pronostiques. Patients et Méthodes: De janvier 1995 à octobre 2001, tous les patients de notre centre présentant des stigmates majeurs de saignement (Forrest I ou II a ) et traités par injections d’adrénaline et/ou pose de clipsont été inclus rétrospectivement. Un traitement à base d’oméprazole IV (80 à 120 mg/j, durant au moins 3 jours) et un contrôle endoscopique (J2–J7) étaient systématiques. 19 variables clinico biologiques et endoscopiques ont été étudiées. Résultats: Soixante dix patients ont été inclus (âge moyen = 51 ans, sexe ratio = 6, ulcère duodénal = 80%,une tare sévère = 40%, Forrest Ia = 9, Ib = 44, IIa = 17). La faisabilité du traitement était de 98,7%, plus élevée avec les injections d’adrénaline (p = 0,03). Le taux d’hémostase initiale était de 88,7% (47/53) avec une tendance en faveur du traitement combiné: 94,7% (18/19) versus respectivement 85,7% (24/28) dans le groupe adrénaline seule et 83,3% (5/6) dans le groupe clips seuls. Le taux de récidive hémorragique précoce était de 15,6% (10/64). Le retraitement endoscopique a permis d’éviter la chirurgie d’hémostase dans 80% (8/10) des cas. Le taux d’hémostase permanente était alors de 88,5% (62/70). 12,8% (9/70) des patients ont été opérés dont 7,1% (5/70) en urgence. Le taux global de mortalité à 30 jours était de 11,4% (8/70, 1 décès lié à l’hémorragie). 9 facteurs étaient prédictifs de mortalité en analyse univariée. Seul le saignement actif était un facteur indépendant (p = 0,03) en analyse multivariée. Conclusion: Le traitement endoscopique des ulcères hémorragiques doit être systématique et standardisé dans chaque centre afin d’améliorer encore le pronostic des ulcères hémorragiques. Les injections d’adrénaline et la pose de clips métalliques sont deux méthodes faisables et efficaces. Le retraitement endoscopique diminue significativement le recours à lachirurgie d’hémostase.
Induction of the Carbon Tetrachloride Hepatoma in Strain L Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Jesse E. Edwards, W. E. Heston, Albert J. Dalton
Journal: JNCI Journal of the National Cancer Institute (1942)

Journal Article Induction of the Carbon Tetrachloride Hepatoma in Strain L Mice Get access Jesse E. Edwards, Jesse E. Edwards research fellow Search for other works by this author on: Oxford Academic PubMed Google Scholar W. E. Heston, W. E. Heston geneticist Search for other works by this author on: Oxford Academic PubMed Google Scholar Albert J. Dalton Albert J. Dalton cytologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 3, Issue 3, December 1942, Pages 297–301, https://doi.org/10.1093/jnci/3.3.297 Published: 01 December 1942
Blood Proteose and Cancer&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Richard J. Winzler, Dean Burk, Marie Hesselbach
Journal: JNCI Journal of the National Cancer Institute (1944)

Blood Proteose and Cancer Get access Richard J. Winzler, Richard J. Winzler research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Dean Burk, Dean Burk senior chemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Marie Hesselbach Marie Hesselbach National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 4, February 1944, Pages 417–428, https://doi.org/10.1093/jnci/4.4.417 Published: 01 February 1944
Orbital Hemangiopericytoma in 68Ga–Prostate-Specific Membrane Antigen–HBED–CC PET/CT
Authors: Jochen Hammes, Carsten Kobe, Ute Hilgenberg, Wolfgang E. Lieb, Alexander Drzezga
Journal: Clinical Nuclear Medicine (2017)

A 76-year-old man with biochemical relapse of prostate cancer underwent 68Ga–prostate-specific membrane antigen PET/CT. Besides a local lymph node metastasis, a nodular structure inside the left orbit caudal to the optic nerve showed increased uptake. A metastasis in this location is unlikely. The subsequently performed MRI showed the structure being T1 hypointense, T2 indifferent, and strongly gadolinium contrast agent enhancing. Histopathologic examination after surgical removal identified the tumor as hemangiopericytoma, which rarely occurs in the orbit. Regarding the intense uptake observed, prostate-specific membrane antigen–targeting PET tracers could bear potential for staging purposes of this tumor entity.
NCCN Guidelines Insights: Palliative Care, Version 2.2017
Authors: Maria Dans, Thomas Smith, Anthony Back, Justin N. Baker, Jessica R. Bauman, Anna C. Beck, Susan Block, Toby Campbell, Amy A. Case, Shalini Dalal, Howard Edwards, Thomas R. Fitch, Jennifer Kapo, Jean S. Kutner, Elizabeth Kvale, Charles Miller, Sumathi Misra, William Mitchell, Diane G. Portman, David Spiegel, Linda Sutton, Eytan Szmuilowicz, Jennifer Temel, Roma Tickoo, Susan G. Urba, Elizabeth Weinstein, Finly Zachariah, Mary Anne Bergman, Jillian L. Scavone
Journal: Journal of the National Comprehensive Cancer Network (2017)

The NCCN Guidelines for Palliative Care provide interdisciplinary recommendations on palliative care for patients with cancer. These NCCN Guidelines Insights summarize and provide context for the updated guidelines recommendations regarding hospice and end-of-life (EOL) care. Updates for 2017 include revisions to and restructuring of the algorithms that address important EOL concerns. These recommendations were revised to provide clearer guidance for oncologists as they care for patients with cancer who are approaching the transition to EOL care. Recommendations for interventions and reassessment based on estimated life expectancy were streamlined and reprioritized to promote hospice referrals and improved EOL care.
NOVEL RISK FACTORS ASSOCIATED WITH MORE SEVERE EXERCISE ASSOCIATED MUSCLE CRAMPING (EAMC): A PROSPECTIVE COHORT STUDY OF 41 698 DISTANCE RUNNERS
Authors: Sonja Swanevelder, Martin Schwellnus, Esme Jordaan
Journal: British Journal of Sports Medicine (2017)

Background EAMC is a common clinical syndrome in endurance runners, and can range in severity. Risk factors for EAMC have been identified and include age, gender, racing distance, a history of chronic diseases, medication, training and competition load, and running injuries. However, to date, risk factors for more severe EAMC (recurrent cramping) have not been investigated. Objective To document risk factors associated with EAMC in distance runners, including more severe EAMC. Design Data analysis from a 2-year prospective cohort study. Patients (or Participants) 41 698 distance runners (21.1 km and 56 km) who completed an online pre-race medical screening questionnaire. Main Outcome Measurements Independent risk factors associated with EAMC (model 1: binary outcome), and risk factors associated with severe EAMC (model 2: defined as recurrent cramping history). Results Significant risk factors (p&lt;0.05) for EAMC (model 1: binary outcome) were: males, age&gt;40 yrs, increased BMI, history of any GIT or kidney/bladder disease; chronic or regular medication use, history of a running injury in the last 12 months, running the 56 km race, recreational running for &lt;5 yrs, training/racing &lt;3 times/week, and slower runners (&gt;6 min/km). In model 2, severe EAMC was associated with all the risk factors for EAMC in model 1, but also included a history of any cardiovascular disease (CVD) symptoms. In model 2, a lower BMI and running in 21.1 km race were also specific risk factors for severe EAMC. Training volume and pace weren't risk factors in model 2. Conclusions Risk factors for the clinical syndrome of EAMC in distance runners are identified, including novel risk factors associated with more severe EAMC (a history of CVD symptoms, lower BMI and shorter race distance). Physicians need to consider secondary causes (including underlying chronic diseases) in the diagnosis and prevention of EAMC, and also consider different risk factor for recurrent (severe) EAMC in endurance athletes.
Abstract P247: APPL1 Transgenic Mice Are Protected from High-Fat Diet--Induced Lipotoxic Cardiomyopathy
Authors: Min Park, Tae-sik Park, Donghai Wu, Aimin Xu, Gary Sweeney
Journal: Circulation Research (2011)

Increased circulating levels of free fatty acid (FA) in obesity and diabetes lead to the accumulation of FA in non-adipose tissue such as myocardium and this is known to be a major contributor to cardiomyopathy. In this present study, we investigated the role of APPL1 (Adaptor protein containing PH domain, PTB domain and Leucine zipper motif-1), an important regulator of insulin signaling, in a model of high fat diet (HFD) induced cardiomyopathy. We fed APPL1 transgenic (Tg) or wild type (wt) mice a high fat (60% kcal) or normal chow diet. After 16 weeks, in wt mice HFD induced hyperinsulinemia and hyperlipidemia, as well as cardiac dysfunction determined by echocardiography system (Vevo 2100). Furthermore, HFD induced cardiac insulin resistance and acetyl CoA carboxylase (ACC) phosphorylation. Lipid analysis using LC/MS/MS showed HFD significantly increased intracellular level of distinct ceramide and diacylglycerol (DAG) species in heart tissue. Interestingly, HFD fed APPL1 Tg mice showed a relatively normal circulating level of FA and improved insulin sensitivity in heart tissue, compared to the wt mice. Lipid analysis indicated that APPL1 Tg mice had approximately 20% reduced intra-myocardial accumulation of ceramides and DAGs after HFD compared to wt mice. APPL1 Tg mice also showed better cardiac performance in ejection fraction and cardiac output under these conditions. In summary, here we demonstrated that APPL1 Tg mice are protected from HFD-induced increases in circulating levels of FA, accumulation of lipotoxic fatty acid derivatives and insulin resistance in myocardial tissue and deterioration in cardiac function.
弱いホスト‐ゲスト相互作用により橋かけした機械的回復力のある,投与型,生体接着性超分子ゼラチンヒドロゲルは細胞浸潤とin situ組織再生を支援する【Powered by NICT】
Authors: Feng Qian, Wei Kongchang, Lin Sien, Xu Zhen, Sun Yuxin, Shi Peng, Li Gang, Bian Liming
Journal: Biomaterials (2016)
PRE-SEASON ISOKINETIC SCREENING OF NEUROMUSCULAR RISK FACTORS IN ELITE FOOTBALL
Authors: Rogério Pereira, Renato Andrade, Ricardo Vidal, Filipe Castanheira, Ana Leal, Cátia Saavedra, Nuno Pais, Hugo Duarte, Luís Silva, Alberto Monteiro, Nuno Loureiro, João Espregueira-Mendes
Journal: British Journal of Sports Medicine (2017)

Background Neuromuscular isokinetic screening as a pre-season test may identify players at risk of injury or undertrained players. Objective Identify, assess and describe unilateral and bilateral knee muscular deficits in elite football players at pre-season screening. Design Retrospective cohort. Setting Elite football divisions. Patients (or Participants) Of 99 eligible male elite footballers, older than 17 years and without knee injury within the last 6 months, 3 were excluded, resulting in a final sample of 96 players (25 yrs old, BMI 23.7 kg·m −2 ). Assessment of Risk Factors Knee isokinetic assessment of both limbs was performed, starting with the non-dominant limb. The test range was set and gravity correction was performed. Before each isokinetic test, players were allowed 4 submaximal repetitions. The isokinetic test consisted of concentric sets of 6 and 8 repetitions, at 60˚/s and 180˚/s, respectively. Main Outcome Measurements Peak torque of knee extensors and flexors at 60˚/s and 180˚/s and conventional ratio at 60˚/s and 180˚/s. Individuals were also analysed for bilateral differences (&gt;10%) and conventional ratio – Con/Con – (&lt;0.47 and &gt;0.80). Results Subgrouping by position, bilateral statistically significant differences were more frequent among defenders and goalkeepers, both for knee extensors and flexors (p&lt;0.05). After individual analysis, 19% and 31% of players displayed significant bilateral asymmetries (&gt;10%) for extensor peak torque at 60˚/s and 180˚/s, respectively; while 21% and 44% showed significant bilateral asymmetries for flexor peak torque at 60˚/s and 180˚/s, respectively. The conventional ratio was abnormal among 7% of players, for both dominant and non-dominant limbs at 60˚/s, and among 11% and 9% for dominant and non-dominant limbs, respectively, at 180˚/s. Conclusions Defenders and goalkeepers tended to present bilateral differences for isokinetic parameters more frequently than other player positions. There was a considerable proportion of players with clinically meaningful bilateral asymmetries, also impacting on unilateral balance. This screening is important to tailor neuromuscular programmes addressing deficits believed to be associated with injury risk, relevant in both primary and secondary injury prevention.
02.34 Enhanced conventional cd4<sup>+</sup> t cell proliferation in sle is associated with up-regulation of microrna-182 and increased il-7 receptor signalling
Authors: Tobias Alexander, Claudia Haftmann, René Riedel, Lars Templin, Jens Humrich, Gerd-Rüdiger Burmester, Andreas Radbruch, Falk Hiepe, Mir-Farzin Mashreghi
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Recent reports have shown dysregulated microRNAs (miRNAs) in murine models of lupus, among them increased expression of microRNA-182 (miRNA-182), which has been demonstrated to target the transcription factor <i>FOXO1</i> in activated murine CD4<sup>+</sup> T cells, leading to spontaneous T cell activation and clonal expansion. Here we aimed to investigate the expression of miR-182 and <i>FOXO1</i> in T cells from human SLE patients. <h3>Methods</h3> Expression levels of miR-182 were analysed with RT-PCR in purified peripheral blood CD4<sup>+</sup> T cells from 9 patients with SLE and age/sex-matched healthy controls (HC). Multicolor flow cytometry was performed to analyse CD4<sup>+</sup> T cell expression for <i>FOXO1</i>, Ki-67, Foxp3, the interleukin-7 receptor-α (CD127) and phosphorylated STAT-5a (pSTAT5). Analysis of serum IL-7 levels was performed with ELISA in 27 SLE patients and HC. Induction of miR-182 was assessed <i>in vitro</i> after polyclonal T cell stimulation in the presence of IL-7, and inhibition of T cell proliferation investigated using mir-182 antagomirs. <h3>Results</h3> MiRNA-182 was significantly upregulated in CD4<sup>+</sup> T cells from SLE patients compared to HC, while the <i>FOXO1</i> expression was significantly decreased. The percentage of proliferating Ki-67<sup>+</sup> conventional Foxp3<sup>-</sup> CD4<sup>+</sup> T cells T<sub>CON</sub> was significantly higher in SLE compared to HC (3.85% vs. 1.58%, p&lt;0.001) and their basal pSTAT5 levels significantly enhanced, suggesting a recent stimulation with common gamma chain(γc)-signalling cytokines. SLE T<sub>CON</sub> displayed decreased expression levels for the <i>FOXO1</i> target gene CD127 (MFI 2021 vs. 2553, p=0.049) and serum IL-7 levels were significantly higher in SLE compared to HC (17.0 pg/ml vs. 10.2 pg/ml, p=0.001). <i>In vitro</i>, miR-182 could be induced by IL-7, and specific inhibition of miR-182 inhibited T cell proliferation and survival. <h3>Conclusion</h3> Our data suggest that enhanced IL7R/STAT5 signalling mediates the induction of miR182 expression, which promotes the proliferation of conventional Foxp3<sup>-</sup> T cells SLE. Collectively, our data provide new insights in the pathophysiology of T cell hyperactivity in SLE and identifies miR-182 as a candidate target for future therapeutic approaches.
Interim analysis of a phase I/II open label, dose-escalating study to investigate safety, tolerability, and preliminary efficacy of the trifunctional anti-HER2/neu x anti-CD3 antibody ertumaxomab in patients with HER2/neu expressing solid tumors progressing after standard therapy.
Authors: Nicole Haense, Claudia Pauligk, Frederik Marme, Dominique Werner, Daniela Sorgius, Wael Hozaeel, Mohammad-Reza Rafiyan, Oliver G. Ottmann, Daniel Klunker, Michael Jäger, Elke Jäger, Horst Lindhofer, Salah-Eddin Al-Batran
Journal: Journal of Clinical Oncology (2014)

3055 Background: Ertumaxomab (ertu) is a bispecific, trifunctional antibody (ab) targeting HER2/neu, CD3 and the Fcγ-receptors I, IIa, and III forming a tri-cell complex between tumor cell, T cell and accessory cells. Patients (pts) with HER2/neu (1+/SISH positive, 2+ and 3+) expressing tumors progressing after standard therapy are treated to investigate safety, tolerability and preliminary efficacy. Methods: In this ongoing investigator driven, non-randomized study, ertu is applied i.v. in 2 cycles following a predefined dose escalating scheme. Each cycle consists of 5 ascending doses (10-500µg) applied weekly within 28 days with a 21 day treatment-free interval. If 2 pts experience a dose limiting toxicity at a given dose level, the maximum tolerated dose (MTD) will have been exceeded. Results: So far, 11 heavily pretreated pts (e.g. breast, rectal, gastric cancer) have been enrolled in the first 4 main cohorts. 1 (9%) pt had a partial remission at end of study (EoS), 2 (18%) pts had a stable disease after the first cycle and PD (progressive disease) at EoS. 7 (63%) pts had a PD after the first cycle and were not further treated. 1 (9%) pt had to be replaced. To date, no therapy related serious adverse event was detected and consequently the MTD is not yet reached. All adverse events (AE) were transient and completely reversible. Most frequent AEs were fatigue (11/11), gastrointestinal disorders (10/11), pyrexia (8/11) and cephalgia (8/11). Single doses up to 300µg were well tolerated in this dose scheme (total dose up to 800 µg per cycle). All pts showed a transient decrease of the CD3+lymphocyte count 24h after infusion. 3/4 analyzed pts developed an anti-tumor immune response demonstrated by the induction of either anti-HER2/neu-abs (3/3) or anti-EpCAM-abs (1/3). Conclusions: Doses up to 300µg were safely administered in an escalating dose scheme. First signs of efficacy with mild and reversible AEs warrant further increasing of dosing. The development of anti-HER2/neu and anti-EpCAM abs suggests the promotion of an immunologic memory. Clinical trial information: NCT01569412.
Valeurs diagnostiques de l’échoendoscopie et de l’imagerie par résonance magnétique pour le diagnostic pré-opératoire d’une infiltration rectosigmoïdienne par une endométriose pelvienne profonde
Authors: C Regis, V Maunoury, D Vinatier, Y Robert, JP Triboulet
Journal: Endoscopy (2004)

Introduction: L’endométriose pelvienne profonde, dont les formes sévères relèvent d’une exérèse chirurgicale complète, peut infiltrer le recto sigmoïde. Le diagnostic préopératoire d’une extension à la paroi digestive favorise une prise en charge chirurgicale optimale. Si l’imagerie par résonance magnétique (IRM) permet un bilan de l’extension pelvienne de la maladie, l’échoendoscopie rectale (EE) a été proposée pour préciser au mieux l’infiltration digestive éventuelle. C’est ce que nous avons voulu vérifier par cette étude. Patients et Méthodes: Trente patientes consécutives avec une endométriose pelvienne profonde, prises en charge par une même équipe chirurgicale, ont été explorées par IRM pelvienne et échoendoscopie rectale (Olympus EUM20). L’exploration échoendoscopique était pratiquée en ambulatoire, après un lavement évacuateur, sans sédation. Les valeurs diagnostiques respectives de l’EE et de l’IRM pour le diagnostic d’envahissement de la paroi digestive, ont été évaluées rétrospectivement sur la base des compte-rendus opératoires et anatomopathologiques. Résultats: Neuf patientes n’ont pas été opérées: aucune ne présentait d’infiltration digestive en EE ou en IRM. Une patiente, avec une infiltration digestive en EE et en IRM, doit être opérée prochainement. Vingt patientes ont été opérées: 13 avaient une infiltration digestive qui a requis une résection segmentaire dans 9 cas et une résection en »barquette« dans 4 cas. L’étude rétrospective des compte-rendus d’IRM, issus pour 6 d’entre eux d’équipes différentes, témoigne parfois de conclusions imprécises concernant le diagnostic d’infiltration digestive. A cette réserve près, la sensibilité de l’EE a été de 85% (vs 54% pour l’IRM), la spécificité 86% (vs 71%), la précision diagnostique 85% (vs 60%) et la valeur prédictive négative 75% (vs 45%) pour le diagnostic d’envahissement de la paroi digestive. Les faux négatifs de l’IRM ont, dans 50% des cas, été observés en cas d’infiltration digestive discrète, ayant donné lieu à une résection en »barquette«. Les 2 faux négatifs de l’EE ont été en rapport avec une exploration non optimale (examen douloureux, charnière non franchie). Conclusion: L’EE complète le bilan de l’extension pelvienne d’une endométriose profonde, en précisant mieux que l’IRM un éventuel envahissement de la paroi digestive. Elle reste néanmoins, dans cette indication particulière, d’interprétation parfois délicate, surtout chez des malades explorées sans sédation.
International cancer seminars: a focus on esophageal squamous cell carcinoma
Authors: G. Murphy, V. McCormack, B. Abedi-Ardekani, M. Arnold, M.C. Camargo, N.A. Dar, S.M. Dawsey, A. Etemadi, R.C. Fitzgerald, D.E. Fleischer, N.D. Freedman, A.M. Goldstein, S. Gopal, M. Hashemian, N. Hu, P.L. Hyland, B. Kaimila, F. Kamangar, R. Malekzadeh, C.G. Mathew, D. Menya, G. Mulima, M.M. Mwachiro, A. Mwasamwaja, N. Pritchett, Y.-L. Qiao, L.F. Ribeiro-Pinto, M. Ricciardone, J. Schüz, F. Sitas, P.R. Taylor, K. Van Loon, S.-M. Wang, W.-Q. Wei, C.P. Wild, C. Wu, C.C. Abnet, S.J. Chanock, P. Brennan
Journal: Annals of Oncology (2017)

The International Agency for Research on Cancer (IARC) and the US National Cancer Institute (NCI) have initiated a series of cancer-focused seminars [Scelo G, Hofmann JN, Banks RE et al. International cancer seminars: a focus on kidney cancer. Ann Oncol 2016; 27(8): 1382–1385]. In this, the second seminar, IARC and NCI convened a workshop in order to examine the state of the current science on esophageal squamous cell carcinoma etiology, genetics, early detection, treatment, and palliation, was reviewed to identify the most critical open research questions. The results of these discussions were summarized by formulating a series of 'difficult questions', which should inform and prioritize future research efforts.