tbuckley/cabot-search huggingface dataset:
Association of Inflammatory Bowel Disease and Acute Anterior Uveitis, but Not Psoriasis, With Disease Duration in Patients With Axial Spondyloarthritis
Authors: Gaëlle Varkas, Nathan Vastesaeger, Heleen Cypers, Roos Colman, Thomas Renson, Liesbet Van Praet, Philippe Carron, Frank Raeman, Mieke Devinck, Lieve Gyselbrecht, Luc Corluy, Yves Piette, Jan Lenaerts, Kristof Thevissen, Benedicte Vanneuville, Filip Van den Bosch, Dirk Elewaut
Journal: Arthritis & Rheumatology (2018)

Objective To determine the link between extraarticular manifestations ( EAM s) and baseline characteristics in patients with axial spondyloarthritis (SpA), and to define their potentially differential prognostic value in 2 large, independent Belgian axial SpA cohorts with distinct recruitment periods. Methods Information on demographic and clinical characteristics and extraarticular manifestations ( EAM s) was obtained from patients with axial SpA originating from the (Be)Giant (Belgian Inflammatory Arthritis and Spondylitis) cohort, which includes consecutive axial SpA patients whose data have been collected since 2010, and from the ASPECT (Ankylosing Spondylitis Patients Epidemiological Cross‐sectional Trial) cohort, a Belgian registry of cross‐sectional data collected between February 2004 and February 2005 from consecutive patients with ankylosing spondylitis ( AS ) or probable AS . Results Among the 1,250 Belgian patients studied, disease duration was associated with risk of developing inflammatory bowel disease ( IBD ), with an increase in risk by 20% per 10 years of disease duration (relative risk [ RR ] 1.2, P = 0.026), and associated with risk of developing acute anterior uveitis, with an increase in risk by 30% per 10 years of disease duration ( RR 1.3, P &lt; 0.001). In the subgroup of 171 newly diagnosed patients with prospective follow‐up data, higher mean C‐reactive protein levels over time were demonstrated in those with acute anterior uveitis or IBD compared to those without EAM s or those with psoriasis alone (each P = 0.01). Conclusion The risk of developing acute anterior uveitis or IBD , but not psoriasis, in patients with axial SpA seems to increase with disease duration and appears to be linked to a higher cumulative exposure to inflammation, thus providing a possible explanation for the differential structural progression observed in those with axial SpA.
Fluoroquinolones versus trimethoprim-sulfamethoxazole for the treatment of Stenotrophomonas maltophilia infections: a systematic review and meta-analysis
Authors: J.-H. Ko, C.-I. Kang, P. Cornejo-Juárez, K.-M. Yeh, C.-H. Wang, S.Y. Cho, M.G. Gözel, S.-H. Kim, P.-R. Hsueh, N. Sekiya, Y. Matsumura, D.-G. Lee, S.-Y. Cho, S. Shiratori, Y.-J. Kim, D.R. Chung, K.R. Peck
Journal: Clinical Microbiology and Infection (2018)
An attempt to predict double expresser DLBCL based on cell of origin and proliferative index (Ki-67): A prospective study from India
Authors: V. Asati, C.S. Premalata, K. Govind Babu, K.C. Lakshmaiah, D. Lokanath, L.A. Jacob, M.C. Suresh Babu, K.N. Lokesh, A.H. Rudresha, L.K. Rajeev, S.C. Smitha, G.V. Giri, D. Koppaka, T. Chaudhuri, A. Anand, R. Chethan, A. Goyal, R. Patidar
Journal: Annals of Oncology (2018)
Socioeconomic Differences in the Epidemiologic Transition From Heart Disease to Cancer as the Leading Cause of Death in the United States, 2003 to 2015
Authors: Katherine G. Hastings, Derek B. Boothroyd, Kristopher Kapphahn, Jiaqi Hu, David H. Rehkopf, Mark R. Cullen, Latha Palaniappan
Journal: Annals of Internal Medicine (2018)

This article has been corrected. The original version (PDF) is appended to this article as a Supplement. Background: Recent data suggest that the United States is in the midst of an epidemiologic transition in the leading cause of death. Objective: To examine county-level sociodemographic differences in the transition from heart disease to cancer as the leading cause of death in the United States. Design: Observational study. Setting: U.S. death records, 2003 to 2015. Participants: Decedents aged 25 years or older, classified by racial/ethnic group. Measurements: All-cause, heart disease, and cancer mortality stratified by quintiles of county median household income. Age- and sex-adjusted mortality rates and average annual percentage of change were calculated. Results: Heart disease was the leading cause of death in 79% of counties in 2003 and 59% in 2015. Cancer was the leading cause of death in 21% of counties in 2003 and 41% in 2015. The shift to cancer as the leading cause of death was greatest in the highest-income counties. Overall, heart disease mortality rates decreased by 28% (30% in high-income counties vs. 22% in low-income counties) from 2003 to 2015, and cancer mortality rates decreased by 16% (18% in high-income counties vs. 11% in low-income counties). In the lowest-income counties, heart disease remained the leading cause of death among all racial/ethnic groups, and improvements were smaller for both heart disease and cancer. Limitation: Use of county median household income as a proxy for socioeconomic status. Conclusion: Data show that heart disease is more likely to be the leading cause of death in low-income counties. Low-income counties have not experienced the same decrease in mortality rates as high-income counties, which suggests a later transition to cancer as the leading cause of death in low-income counties. Primary Funding Source: National Institute on Minority Health and Health Disparities.
Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State
Authors: Chia Li, Jovana Navarrete, Jing Liang-Guallpa, Chunxia Lu, Samuel C. Funderburk, Rui B. Chang, Stephen D. Liberles, David P. Olson, Michael J. Krashes
Journal: Cell Metabolism (2018)
Autophagy inhibitor enhance ZnPc/BSA nanoparticle induced photodynamic therapy by suppressing PD-L1 expression in osteosarcoma immunotherapy
Authors: Wei Yu, Yitian Wang, Jian Zhu, Libin Jin, Bing Liu, Kaishun Xia, Junjie Wang, Jianqing Gao, Chengzhen Liang, Huimin Tao
Journal: Biomaterials (2018)
Abstract 16266: Effects of Japan Diet-Based Antihypertensive Diet on Blood Pressure and Its Variability in Subjects With Untreated Normal High Blood Pressure and Stage I Hypertension: A Randomized Controlled Trial
Authors: Seiji Umemoto, Reo Kawano, Atsuko Kawamura, Uran Onaka, Sayaka Motoi, Makoto Mitarai
Journal: Circulation (2017)

Introduction: The Dietary Approach to Stop Hypertension (DASH) diet is recommended by the American Heart Association to lower blood pressure (BP). We previously reported that the Japan Diet-based D...
Incorrect P Value in: Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation
Authors: Maron Harris
Journal: JAMA (2010)

a number and corresponding percent were incorrectly stated in the text.On page 1051, center column, second paragraph, the second sentence should have read, "Of the original 393 participants in PROG 9509, 55 (14%) died and an additional 58 patients (14.8%) did not participate in the survey, reducing study power and raising the possibility of bias.
Circulating cell-free DNA molecular profiling among east Asian patients reveals activating MET alterations are common in diverse advanced cancer types
Authors: S. Ikeda, Y. Kumaki, T.A. Rich, Y. Shiotsu, A. Franovic, V.M. Raymond, R. Kurzrock, R.B. Lanman, J. Lee, T.S.K. Mok
Journal: Annals of Oncology (2018)
PTH-032 Mortality following ERCP for benign pathology in england between 2003 and 2015
Authors: Phil Harvey, Simon Baldwin, Jemma Mytton, Ben Coupland, Felicity Evison, Prashant Patel, Nigel Trudgill
Journal: Endoscopy (2018)

<h3>Introduction</h3> Recent data on ERCP for the palliation of malignant biliary obstruction demonstrated high mortality and significant variation in outcomes between providers. We have therefore examined ERCP outcomes for in benign pathology. <h3>Methods</h3> Hospital Episode Statistics (HES) include diagnostic and procedural data for all hospital attendances in England. HES is linked to the Office for National Statistics to provide mortality data. All subjects undergoing their first ERCP between 2003 and 2015 were included. Subjects with a relevant cancer diagnosis 2 years before, or after ERCP were excluded. Associations between demographics, co-morbidities, unit ERCP volume and mortality were examined by logistic regression analysis. <h3>Results</h3> 2 01 851 subjects were included. 64.2% were female, median age 67 (IQR 51–79). 70.0%, 13.9% and 16.1% had a Charlson Co-morbidity score of 0, 1–4 and &gt;4 respectively. A majority were during emergency admissions (53.5%). 7 day, 30 day and 12 month mortality was 0.8%, 2.3% and 8.0% respectively. 30 day mortality was 3.5% in emergency cases compared to 0.8% in elective. The re-admission rate within 30 days was 11.7%. Repeat ERCP was required within 90 days in 13.9%. 30 day mortality was positively associated with: male gender (OR 1.24 (95% CI:1.17–1.32),p&lt;0.001), Black ethnicity (1.55 (1.12–2.14),p=0.008),Charlson co-morbidity score 1–4 (1.18(1.06–1.31),p=0.002), score &gt;4 (3.55(3.31–3.81),p&lt;0.001), increasing age quintile 47–62 (3.43(2.65–4.44),p&lt;0.001), age 63–72 (7.01(5.48–8.97),p&lt;0.001), age 73–81 (11.50(9.05–14.62),p&lt;0.001) and age &gt;81 (20.31(16.03–25.74),p&lt;0.001). Factors associated with reduced mortality included; elective rather than emergency admission (0.37 (0.33–0.40),p&lt;0.001), and day case procedures (0.86 (0.74–0.99),p=0.031). Advancing year of procedure 2004/05 (1.01(0.87–1.18), p=0.859, 2009/10 (0.71(0.61–0.83), 2014/15 (0.61, 0.53–0.71, p&lt;0.001) was also associated with reduced mortality. Provider volume was not associated with mortality: volume knot 1 (1.00(1.00–1.00),p=0.445), knot 2 (1.00(1.00–1.01),p=0.253), knot 3 (0.99(0.98–1.01),p=0.288). <h3>Conclusions</h3> 30 day mortality following ERCP for benign pathology is associated with advancing age, increasing co-morbidity and male gender. Outpatient elective procedures were negatively associated with mortality. Mortality has reduced in recent years, but no variation in mortality was observed based upon provider volume.
Abstract 13983: Tricuspid Regurgitation is Independently Associated With Increased Risk of Mortality in Patients with Low-Flow Low-Gradient Aortic Stenosis and Reduced Ejection Fraction-Results From the TOPAS Study
Authors: Abdellaziz Dahou, Julien Magne, Marie-Annick Clavel, Romain Capoulade, Philipp E Bartko, Jutta Bergler-klein, Mario Senechal, Gerald Mundigler, Ian G Burwash, Henrique B Ribeiro, Kim O’Connor, Patrick Mathieu, Helmut Baumgartner, Jean G Dumesnil, Raphael Rosenhek, Eric Larose, Josep Rodés-Cabau, Philippe Pibarot
Journal: Circulation (2014)

Background: Tricuspid regurgitation (TR) is often observed in patients (pts.) with low-flow, low-gradient aortic stenosis (LF-LG AS) and low ejection fraction (EF). Its impact on prognosis remains unknown. The objective of this study was to examine the impact of TR on mortality in these pts. Methods: 211 pts. (age=73±10 yrs; 77% men) with LF-LG AS (mean gradient&lt;40 mmHg, AVA ≤0.6 cm2/m2) and low EF (≤40%) were prospectively enrolled and 125 (59%) underwent aortic valve replacement (AVR) within 3 months following inclusion. AS severity was assessed by the projected AVA. The severity of TR was graded according to ASE guidelines. Right ventricular (RV) function was assessed using an integrative approach and classified as normal or reduced. Results: Among the 211 pts., 76 (36%) had TR (24% mild TR and 12% moderate/severe TR). During a mean follow up of 2.4±2.2 yrs, 104 (49%) died. In univariable analysis, TR was associated with an increased risk of all-cause mortality (overall TR: HR=1.82; 95% CI=1.22-2.71; p=0.004; mild TR: HR=1.62; 95% CI=1.02-2.54; p=0.04; moderate/severe TR: HR=2.30; 95% CI=1.27-3.93; p=0.007). After adjustment for risk factors and echocardiographic parameters including RV function, TR was an independent predictor of mortality (overall TR: HR=1.88; 95% CI=1.08-3.23; p=0.02; mild TR: HR=2.19; 95% CI=1.00-4.77; p=0.05; moderate/severe TR: HR=2.68; 95% CI=1.08-6.32; p=0.03). Furthermore, moderate/severe TR was an independent predictor of 30-day mortality following AVR compared to none/trace TR (OR=7.24; p=0.01) and mild TR (OR=4.70; p=0.05). Conclusion: In patients with LF-LG AS and low EF, TR is independently associated with an increased risk of mortality. Moderate/severe TR is associated with increased 30-day mortality following AVR. Further studies are needed to determine whether TR is a risk marker or risk factor of mortality, and whether concomitant surgical correction at the time of AVR can improve outcome in these high risk patients.
Hypersensitivity pneumonitis and its correlation with ambient air pollution in urban India
Authors: Sheetu Singh, Bridget F. Collins, Mohan Bairwa, Jyotsna M. Joshi, Deepak Talwar, Nishtha Singh, Jai K. Samaria, Daya K. Mangal, Virendra Singh, Ganesh Raghu
Journal: European Respiratory Journal (2018)

<b>A higher proportion of patients diagnosed with hypersensitivity pneumonitis lives in cities with higher levels of air pollutants. Further studies are warranted to investigate the significance of the association of air pollution to possible causality of HP.</b>http://ow.ly/zH3U30mtocl
Quantitative analysis of lung sounds for monitoring idiopathic pulmonary fibrosis: a prospective pilot study
Authors: Giacomo Sgalla, Anna Rita Larici, Nicola Sverzellati, Brian Bartholmai, Simon L.F. Walsh, Dragana Nikolic, Anna Barney, Sophie Fletcher, Mark Jones, Donna D Davies, Luca Richeldi
Journal: European Respiratory Journal (2018)

Accurate monitoring of disease progression in idiopathic pulmonary fibrosis (IPF) is crucial for predicting prognosis and optimising management, including the initiation of therapies, the appropriate timing of supportive care and the prompt referral for lung transplantation. While forced vital capacity (FVC) via spirometry has been accepted as the most feasible and reliable tool to assess the deterioration in these patients in clinical practice as well as in randomised controlled trials [1, 2], in recent years both visual evaluation and computer-based analysis of high-resolution computed tomography (HRCT) parenchymal patterns have been shown to correlate with disease severity based on FVC and predict outcome in several fibrotic lung diseases, including IPF [3–5]. Quantitative analysis of lung sounds may represent a tool for monitoring patients with idiopathic pulmonary fibrosis <http://ow.ly/9ICq30naWk6>
Efficacy of palliative chemotherapy (CTx) by lines of treatment in patients (pts) with recurrent/metastatic esophageal squamous cell cancer (SCC): Retrospective analysis of 103 patients in a single center
Authors: E. Kim, S.R. Park, J.H. Kim, Y.-H. Kim, H.R. Kim, S.-B. Kim
Journal: Annals of Oncology (2018)
Comparison of Insonation-Augmented Physical Examination With Standard Physical Examination in Detecting Severe Left-Sided Valve Disease
Authors: Edgar Argulian, Roberto Ramirez, Steven Hobson, Chirag Bavishi, Abel Casso Dominguez, Allison Selby, Soheila Talebi, Pedro Moreno, Amir A. Ahmadi, Jeroen J. Bax, Jagat Narula
Journal: JACC. Cardiovascular imaging (2018)
Antimicrobials in acute and long-term care: a point in time along the way to improved use
Authors: Melinda M. Neuhauser, J. Todd Weber
Journal: Eurosurveillance (2018)

Preview this article: Antimicrobials in acute and long-term care: a point in time along the way to improved use, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/23/46/eurosurv-23-46-1-1.gif
Deceased-donor acute kidney injury is not associated with kidney allograft failure
Authors: Isaac E. Hall, Enver Akalin, Jonathan S. Bromberg, Mona D. Doshi, Tom Greene, Meera N. Harhay, Yaqi Jia, Sherry G. Mansour, Sumit Mohan, Thangamani Muthukumar, Peter P. Reese, Bernd Schröppel, Pooja Singh, Heather R. Thiessen-Philbrook, Francis L. Weng, Chirag R. Parikh
Journal: Kidney International (2018)
Monocyte‐Derived Interleukin‐1β As the Driver of S100A12‐Induced Sterile Inflammatory Activation of Human Coronary Artery Endothelial Cells: Implications for the Pathogenesis of Kawasaki Disease
Authors: Giulia Armaroli, Emely Verweyen, Carolin Pretzer, Katharina Kessel, Keiichi Hirono, Fukiko Ichida, Mako Okabe, David A. Cabral, Dirk Foell, Kelly L. Brown, Christoph Kessel
Journal: Arthritis & Rheumatology (2018)

Kawasaki disease (KD) is an acute vasculitis of childhood, predominantly affecting the coronary arteries. S100A12, a granulocyte-derived agonist of both the receptor for advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR-4), is strongly up-regulated in KD. This study was undertaken to investigate the potential contributions of S100A12 to the pathogenesis of KD.Serum samples from patients with KD (n = 30) at different stages pre- and post-intravenous immunoglobulin (IVIG) treatment were analyzed for the expression of S100A12, cytokines, chemokines, and soluble markers of endothelial cell activation. Primary human coronary artery endothelial cells (HCAECs) were analyzed for responsiveness to direct stimulation with S100A12 or lipopolysaccharide (LPS), as assessed by real-time quantitative reverse transcription-polymerase chain reaction analysis of cytokine and endothelial cell adhesion molecule messenger RNA expression. Alternatively, HCAECs were cultured in conditioned medium obtained from primary human monocytes that were stimulated with LPS or S100A12 in the absence or presence of IVIG or cytokine antagonists.In the serum of patients with KD, pretreatment S100A12 levels were associated with soluble vascular cell adhesion molecule 1 titers in the course of IVIG therapy (rs = -0.6, P = 0.0003). Yet, HCAECs were not responsive to direct S100A12 stimulation, despite the presence of appropriate receptors (RAGE, TLR-4). HCAECs did, however, respond to supernatants obtained from S100A12-stimulated primary human monocytes, as evidenced by the gene expression of inflammatory cytokines and adhesion molecules. This response was strictly dependent on interleukin-1β (IL-1β) signaling (P < 0.001).In its role as a highly expressed mediator of sterile inflammation in KD, S100A12 appears to activate HCAECs in an IL-1β-dependent manner. These data provide new mechanistic insights into the contributions of S100A12 and IL-1β to disease pathogenesis, and may therefore support current IL-1-targeting studies in the treatment of patients with KD.
Cervical screening: GP leaders slam Capita over failure to send up to 48 500 letters
Authors: Gareth Iacobucci
Journal: BMJ (2018)

The BMA has urged NHS England to strip Capita of its contract to provide back office support services to GPs after it emerged that as many as 48 500 women have not received information about cervical cancer screening because of a system error.

NHS England said that an “administrative error” had led to thousands of invitations, reminder letters, and screening results not being sent to patients.

This is the latest in a series of failings12 by Capita since it was contracted to provide GP back office services under the name Primary Care Support England in September 2015.

The BMA’s GP committee said that Capita’s stewardship of the service had …
FDA announces crackdown on e-cigarettes in bid to reduce teenage vaping
Authors: Bob Roehr
Journal: BMJ (2018)

The US Food and Drug Administration (FDA) has tabled new regulations1 that will make it harder to buy e-cigarettes, the flavoured liquids within them, and menthol versions of traditional cigarettes.

The rule change was announced on 15 November by FDA commissioner Scott Gottlieb, who said the purpose was to make nicotine products “less accessible and less appealing to children.”

The fact that nearly 90% of Americans who smoke start doing so before the age of 18 has driven the decision. Additionally, new data from the 2018 National Youth Tobacco Survey show “a 78% increase in current e-cigarette use among high school students” in the past year, Gottlieb said. The sweet flavours of vaporised products and the ease with which they can be …
Tepotinib in non-small cell lung cancer (NSCLC) with MET-exon 14 skipping mutations (METex14+) and MET amplification (METamp); A phase II trial in progress
Authors: P. Paik, H. Sakai, R. Bruns, J. Scheele, J. Straub, E. Felip
Journal: Annals of Oncology (2018)
Preliminary Analysis of the Australasian Leukaemia and Lymphoma Group (ALLG) MM17 Trial: Response Adaptive Salvage Treatment with Carfilzomib-Thalidomide-Dexamethasone (KTd) for Newly Diagnosed Transplant Eligible Multiple Myeloma Patients Failing Front-Line Bortezomib-Based Induction Therapy
Authors: Andrew Spencer, Hang Quach, Noemi Horvath, Ian H. Kerridge, Flora Yuen, Edwin Sze-Hung Lee, Edward S. Morris, Anna Kalff, Krystal Bergin, Shreerang Sirdesai, Malgorzata Gorniak, Sridurga Mithraprabhu, Tiffany Khong, John Reynolds
Journal: Blood (2018)
Ophthalmology Objectives for Medical Students: Revisiting What Every Graduating Medical Student Should Know
Authors: Emily B. Graubart, Evan L. Waxman, Susan H. Forster, JoAnn A. Giaconi, Jamie B. Rosenberg, Prithvi S. Sankar, Anju Goyal, Rukhsana G. Mirza
Journal: Ophthalmology (2018)
Does neoadjuvant chemotherapy promote chemoresistance after recurrence in patients with muscle-invasive bladder cancer?
Authors: S. Hatakeyama, H. Kodama, S. Konishi, K. Okita, H. Yamamoto, A. Imai, T. Yoneyama, Y. Hashimoto, T. Koie, C. Ohyama
Journal: Annals of Oncology (2018)
A China-manufactured bevacizumab biosimilar, HLX04, matches bevacizumab sourced from China, USA and the European Union
Authors: Y. Ding, T. Yu, J. Sun, M. Wu, Q. Chen, H. Qian, L. Xie, X. Zhang, E. Liu, W. Jiang, S. Liu, A. Luk
Journal: Annals of Oncology (2018)
Outcomes of gemcitabine-docetaxel as second-line chemotherapy in patients of advanced soft tissue sarcoma: A retrospective analysis
Authors: K. Gupta, S. Parthiban, S. Kumar, S. Srinivas, D.H. Vallathol, R. Chanana, G.S. Grewal, N. Rathnasamy, A. Goel, J. Bajpai
Journal: Annals of Oncology (2018)