AB0736 The data of central aortic pressure and pulse wave velocity in patients with ankylosing spondylitis
Authors: T Aksenova, N Ivashhenko, S Tsarenok, V Gorbunov, P Gromov
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Pulse Wave Velocity (PWV) is the main determinant of arterial stiffness. In recent years the increased arterial stiffness in Ankylosing Spondylitis was shown [1]. The most of investigations of arterial stiffness in ankylosing spondylitis were performed on the treatment by anti TNF-therapy [2]. However, today this issue has not been adequately studied. <h3>Objectives</h3> To evaluate the data of central aortic pressure and PWV and their relationship with Ankylosing Spondylitis. <h3>Methods</h3> 49 patients with Ankylosing Spondylitis aged between 19 and 60 (mean age 39.6±10.6) were examined. This group (group 1) included 38 men, 11 woman. Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) was 3.11±0.55. Duration of Ankylosing Spondylitis was from 0.5 to 20 years (mean 5.87±4.76 years). X-ray stage sacroiliac joints (according Modified New York Criteria) was 2.59±1.42. The control group included 33 healthy individuals. The groups were similar in age and sex. 10 patients with ankylosing spondylitis have history of arterial hypotension, however, at the time of inclusion in this study their blood pressure was stabilized. The groups did not differ by office blood pressure parameters and heart rate. Indicators of central aortic pressure and PWV were determined by applanation tonometry by SphygmoCor, Australia. For statistical analysis we used Mann-Whitney criteria and Spirmen correlation method. The study was based on GCP principles. <h3>Results</h3> Increased levels of central systolic blood pressure (118.02±14.02 vs 101.1±10.2, p=0.00001), central diastolic blood pressure (80.23±11.86 vs 71.8±7.3, p=0,001) were determined in patients with Ankylosing Spondylitis. Patients with Ankylosing Spondylitis demonstrated the increase in central mean pressure compared to control groop on 17.2% (108.5±13.6 vs 92.6±9.4 p=0.0001). Pulse Wave Velocity (PWV) in the carotid-femoral segment in patients with ankylosing spondylitis was 6.5±1.3 m/sec vs 5.2±0.96 m/sec (p=0.0001) in the control group. The levels of augmentation pressure and Subendocardial viability ratio (SERV) were similar in the examined groups. PWV was directly correlated with trangulus-to-wall (r=0,41; p=0,005) and with X-ray stage of sacroiliitis (r=0,31; p=0,043) and negative correlated with Lumbar flexion (Shober test) (r= - 0,38; p=0,009). <h3>Conclusions</h3> Increasing indicators of arterial stiffness, such as, PWV, central systolic blood pressure, central diastolic blood pressure, central mean pressure were determined in patients with Ankylosing Spondylitis. The relationship between clinical data, X-ray stage and PWV was demonstrated. <h3>Disclosure of Interest</h3> T. Aksenova Shareholder of: nothing to declare, Grant/research support from: nothing to declare, Consultant for: nothing to declare, Employee of: nothing to declare, Paid instructor for: nothing to declare, Speakers bureau: nothing to declare, N. Ivashhenko Shareholder of: nothing to declare, Grant/research support from: nothing to declare, Consultant for: nothing to declare, Employee of: nothing to declare, Paid instructor for: nothing to declare, Speakers bureau: nothing to declare, S. Tsarenok Shareholder of: nothing to declare, Grant/research support from: nothing to declare, Consultant for: nothing to declare, Employee of: nothing to declare, Paid instructor for: nothing to declare, Speakers bureau: nothing to declare, V. Gorbunov Shareholder of: nothing to declare, Grant/research support from: nothing to declare, Consultant for: nothing to declare, Employee of: nothing to declare, Paid instructor for: nothing to declare, Speakers bureau: nothing to declare, P. Gromov Shareholder of: nothing to declare, Grant/research support from: nothing to declare, Consultant for: nothing to declare, Employee of: nothing to declare, Paid instructor for: nothing to declare, Speakers bureau: nothing to declare <h3>References</h3> Berg I., Van der Heijde D., Dagfinrud H., Seljeflot I., Olsen I. C., Kvien T., Semb A., Provan S. Disease activity in ankylosing spondylitis and associations to markers of vascular pathology and traditional cardiovascular disease risk factors: a cross-sectional study. The Journal of Rheumatology. 2015; 42 (4) 645–653. doi: 10.3899/jrheum.141018. Tam L.-S., Shang Q., Kun E. W., Lee K.-L., Yip M.-L., Li M., Li T.K., Zhu T.Y., Pui M.O., Li E.K., Yu C.-M. The effects of golimumab on subclinical atherosclerosis and arterial stiffness in ankylosing spondylitis – a randomized, placebo-controlled pilot trial. Rheumatology. 2014;53(6):1065–1074. doi:10.1093/rheumatology/ket469.