tbuckley/cabot-search huggingface dataset:
Peut-on raccourcir le temps de lecture d'une capsule endoscopique du grêle? Validation de l'algorithme informatique »Quick-view«
Authors: JC Saurin, MG Lapalus, F Cholet, PN d'Halluin, B Filoche, M Gaudric, S Sacher-Huvelin, C Savalle, M Frederic, P Adenis Lamarre, E Ben Soussan
Journal: Endoscopy (2009)

Introduction: La lecture d'une capsule endoscopique du grêle est de 30 minutes en moyenne. Réduire ce temps de lecture, et éventuellement optimiser la détection de lésions cliniquement importantes de l'intestin grêle est un objectif que voudraient atteindre plusieurs systèmes de détection informatique d'images anormales, actuellement non validés, dont la fonction Quick View (QV) de la firme Given Imaging. Le but de ce travail était d'évaluer la sensibilité et la spécificité d'une lecture en mode QV, et la fiabilité de l'algorithme.
Management of carcinoid syndrome (CS): A systematic review of systemic treatment options.
Authors: Edward M. Wolin, Al Bowen Benson
Journal: Journal of Clinical Oncology (2018)

516 Background: CS is a major cause of symptom burden (diarrhea/flushing) in patients (pts) with neuroendocrine tumors and is associated with shortened survival and severe complications such as carcinoid heart disease. We performed a systematic review of clinical evidence for CS systemic treatments. Methods: PubMed, Embase, and Cochrane databases were searched. Large ( &gt; 60 pt) prospective clinical trials investigating the efficacy/safety of systemic treatment options for pts with CS were eligible for inclusion. Data extracted included study design, pt population, interventions, prior treatments, permitted concomitant medications, study endpoints/statistical analyses, and efficacy/safety outcomes. Results: Six large prospective clinical trials (total 953 pts) were identified from 144 search results. Significant heterogeneity existed in pt populations, control groups (placebo vs active comparator), duration of therapy, study endpoints, and efficacy/safety data reporting. Interventions assessed were long-acting and subcutaneous octreotide (OCT &amp; OCT SC), lanreotide (LAN), telotristat ethyl (TE)+somatostatin analogues (SSA), pasireotide (PAS), and everolimus (EVE)+OCT. Symptom response was variably assessed by the frequency of diarrhea/flushing and/or receipt of rescue short-acting SSA in 5/6 studies; a significant improvement in at least one of these measures occurred in 4 studies (OCT and OCT SC; LAN; TE+SSA). Failure to meet symptom response criteria ranged from 29-82% in the studies. Reported reductions in CgA and/or 5-HIAA reached statistical significance in 3 studies (LAN; EVE+OCT; TE+SSA). Interventions were generally well tolerated. Two phase 3 trials focused specifically on management of CS symptoms refractory to SSA; strategies included switching to PAS or an increased dose of OCT (40 mg q28d) for refractory diarrhea/flushing, or receipt of TE with continued SSA for refractory diarrhea. Conclusions: SSA provide substantial symptom relief for pts with CS. For refractory symptoms, TE can be added, SSA dose increased, and metastasis debulking can be used (with surgery, hepatic artery embolization, ablation, and PRRT). The addition of biologic agents to SSA can further improve CS management.
ENDOSCOPIC VACUUM-ASSISTED CLOSURE SYSTEM (E-VAC) FOR THE TREATMENT OF UPPER GASTRO-INTESTINAL ANASTOMOTIC LEAKAGES: REPORT OF TWO CASES
Authors: H Belkhodja, O Glehen, E Cotte, G Passot, G Phelip, M Chauvenet, P Rousset, S Nancey, G Boschetti
Journal: Endoscopy (2018)

Treatment of digestive anastomotic leakages remains challenging and there are no specific recommendations of care. Recently, endoscopic vacuum-assisted closure system (E-VAC) was developed and used to treat intestinal leakage not responding to standard treatment. This technique provides wound drainage, promotes tissue granulation and closure of the fistula. Data come from cases reports or small series suggesting that (E-VAC) is a safe and effective procedure.
A phase 3 randomized, placebo-controlled study assessing the efficacy and safety of epoetin-α in anemic patients with low-risk MDS
Authors: Pierre Fenaux, Valeria Santini, Maria Antonietta Aloe Spiriti, Aristoteles Giagounidis, Rudolf Schlag, Atanas Radinoff, Liana Gercheva-Kyuchukova, Achilles Anagnostopoulos, Esther Natalie Oliva, Argiris Symeonidis, Mathilde Hunault Berger, Katharina S. Götze, Anna Potamianou, Hari Haralampiev, Robert Wapenaar, Iordanis Milionis, Uwe Platzbecker
Journal: Leukemia (2018)

Erythropoiesis-stimulating agents are first choice for treating anemia in low-risk MDS. This double-blind, placebo-controlled study assessed the efficacy and safety of epoetin-α in IPSS low- or intermediate-1 risk (i.e., low-risk) MDS patients with Hb ≤ 10.0 g/dL, with no or moderate RBC transfusion dependence (≤4 RBC units/8 weeks). Patients were randomized, 2:1, to receive epoetin-α 450 IU/kg/week or placebo for 24 weeks, followed by treatment extension in responders. The primary endpoint was erythroid response (ER) through Week 24. Dose adjustments were driven by weekly Hb-levels and included increases, and dose reductions/discontinuation if Hb > 12 g/dL. An independent Response Review Committee (RRC) blindly reviewed all responses, applying IWG-2006 criteria but also considering dose adjustments, drug interruptions and longer periods of observation.A total of 130 patients were randomized (85 to epoetin-α and 45 to placebo). The ER by IWG-2006 criteria was 31.8% for epoetin-α vs 4.4% for placebo (p < 0.001); after RRC review, the ER was 45.9 vs 4.4% (p < 0.001), respectively. Epoetin-α reduced RBC transfusions and increased the time-to-first-transfusion compared with placebo.Thus, epoetin-α significantly improved anemia outcomes in low-risk MDS. IWG-2006 criteria for ER may require amendments to better apply to clinical studies.
miR-15a regulation of endothelial radiation sensitivity in colorectal cancer.
Authors: Shushan Rajesh Rana, Cristina Espinosa, Rebecca Ruhl, Latroy Robinson, Charles R. Thomas, Sudarshan Anand
Journal: Journal of Clinical Oncology (2018)

709 Background: Radiation dose escalation causes significant changes within the tumor microenvironment (TME) to enhance tumor cell death including altered microRNA (miR) levels. Among endothelial miRs, we identified miR-15a exhibits dose dependent differential regulation. miR-15a targets a key determinant of endothelial cell (EC) radiosensitivity, acid sphingomyelinase (SMPD1), an enzyme that drives rapid EC apoptosis via enhanced ceramide production. In colorectal cancer (CRC) (n = 182 patients), high miR-15a is associated with worse 5-year progression free and overall survival. miR-15a also affects immune function by promoting a pro-inflammatory TME milieu. We hypothesized miR-15a inhibition will increase tumor cell death through preservation of EC SMPD1, enhancing endothelial apoptosis and inflammatory cytokine upregulation. Methods: Using TaqMan Human miR panels, miRs were profiled in human umbilical vein ECs (HUVECs) after single 2 vs 20 Gy treatment. miR-target prediction programs identified miRs targeting SMPD1. In vitro gain and loss of function studies were performed with miR transfections in HUVECs and CT26 CRC cells. CXCL10 expression was measured by qRT-PCR. Caspase 1 activation was measured by a luminescence based assay. A CT26 syngeneic CRC flank murine model was used for in vivo miR-15a inhibitor assessment administered via tail vein injection unencapsulated or encapsulated in vascular-targeted 7C1 nanoparticles. Results: Among miRs targeting SMPD1, miR-15a exhibited the greatest differential change in HUVECs 6h post-IR between low and high dose radiation. Lower dose was associated with higher miR-15a and vice versa. Further, miR-15a levels inversely correlated with SMPD1. Exogenous miR-15a significantly decreased SMPD1 mRNA and protein. miR-15a inhibition decreased proliferation in both HUVECs and CT26 cells and increased apoptosis when combined with radiation. miR-15a inhibition increased endothelial CXCL10 expression and caspase-1 activation. Both systemic and vascular-targeted miR-15a inhibitor significantly diminished tumor growth in vivo. Conclusions: Our data suggests inhibition of vascular miR-15a is sufficient to decrease tumor growth likely due to rescue of endothelial SMPD1.
TRANSORAL OUTLET REDUCTION FOR WEIGHT REGAIN AFTER GASTRIC BYPASS: DOES ONLY SUTURING MATTER?
Authors: V Bove, I Boškoski, R Landi, G Gibiino, L Laterza, F Mangiola, A Tringali, P Familiari, V Perri, G Costamagna
Journal: Endoscopy (2018)

Enlargement of gastrojejunal anastomosis is associated with weight regain after Roux-en-Y-Gastric-Bypass (RYGB). Transoral Outlet Reduction (TORe) has proven safe and effective for treatment of weight regain. The objective was to evaluate the weight loss and quality of life after TORe.
Validation prospective multicentrique de marqueurs moléculaires pour le diagnostic différentiel entre adénocarcinome pancréatique et pancréatite chronique pseudo-tumorale
Authors: B Bournet, A Souque, F Muscari, P Senesse, E Assenat, M Barthet, N Lesavre Rosenzweig, P Hammel, A Aubert, D O'Toole, P Lévy, P Ruszniewski, J Escourrou, P Cordelier, L Buscail
Journal: Endoscopy (2009)

Introduction: Le diagnostic différentiel entre adénocarcinome pancréatique (CP) et pancréatite chronique (PC) est très difficile. Un ensemble de marqueurs moléculaires spécifiques de l'une ou l'autre des affections ont été isolés de façon rétrospective après études par puce à ADN à partir de pièces opératoires. Le but était de valider de façon prospective et multicentrique si l'analyse de 22 de ces marqueurs au sein du matériel de cytoponction sous échoendoscopie était fiable pour le diagnostic différentiel entre CP et PC.
ENDOSCOPIC MANAGEMENT WITH PLASTIC STENTS OF NONANASTOMOTIC BILIARY STRICTURES FOLLOWING LIVER TRANSPLANTATION: A SINGLE CENTER EXPERIENCE
Authors: F Barbaro, A Tringali, A Baldan, I Boskoski, P Familiari, G Onder, V Perri, G Costamagna
Journal: Endoscopy (2018)

NonAnastomotic Biliary Strictures (NABS) following Liver Transplantation (OLT) are difficult to treat and show, in the few published studies, a significantly worse outcome when compared to Anastomotic Biliary Strictures (ABS). The long-term results of endoscopic treatment with plastic stents of NABS following OLT was analyzed.
IS THE DIVERTICULAR PAPILLA A FACTOR IN THE FAILURE OF CANULATION OF THE COMMON BILE DUCT IN BILIARY STONES PATHOLOGY?
Authors: F Nejjari, H Seddik, H Boutalaka, I El Koti, K Loubaris, S Jamal, R Berraida, A Benkirane
Journal: Endoscopy (2018)

Duodenal diverticulum is common (6 – 20%). These may be a difficulty in cannulation of the common bile duct and are more frequent associated with biliary stones. The aims of the stady are calculate the prevalence of juxta-papillary diverticulum in patients with biliary stones and evaluate the influence of juxtapillary diverticulum on the success rate of the cannulation of the CBD in biliary stones pathology.
TREATMENT OF ACUTE CHOLECYSTITIS WITH A TRANSPAPILLARY GALLBLADDER STENTING
Authors: B Moreira, L Pérez, S Maestro, F Santos, R Madrigal, J Barcenilla, A Pérez, F Igea
Journal: Endoscopy (2018)

To verify the efficacy, complications and readmissions for the treatment of acute cholecystitis and choledocholithiasis by performing vesicular drainage through the endoscopic placement of transpapillary cholecystoduodenal stent during ERCP, in patients with high surgical risk.
Prediction of the Clinical Course of Behçet's Colitis According to Macroscopic Classification by Colonoscopy
Authors: J S Kim, S H Lim, I J Choi, H Moon, H C Jung, I S Song, C Y Kim
Journal: Endoscopy (2000)

Background and Study Aims: The lesions in Behçet's colitis show aphthoid or punched-out ulceration, but the macroscopic types of lesion found have not been defined. To predict the clinical outcome in patients with Behçet's colitis according to the colonoscopic findings, we classified the characteristic colonic ulcers, evaluated the efficacy of medical treatment on colonoscopic lesions, and calculated the operation rates and recurrence rates relative to the macroscopic types.
Suivi et traitement endoscopique des polyposes duodénales sévères de patients atteints de polypose adénomateuse familiale
Authors: D Moussata, B Napoléon, V Lepilliez, MG Lapalus, JC Cenni, C Partensky, T Ponchon, JA Chayvialle, JC Saurin
Journal: Endoscopy (2009)

Introduction: L'adénocarcinome duodénal est la deuxième cause de mortalité après colectomie dans la polypose adénomateuse familiale. Les adénomes duodénaux sont présents chez quasiment tous les patients, mais avec une sévérité variable classée en 4 stades (score de Spiegelman) prenant en compte le nombre, la taille, l'aspect tubulo-villeux et le degré de dysplasie. Au stade IV, l'attitude de référence est chirurgicale mais un traitement endoscopique est parfois proposé. But: Evaluer l'efficacité et les risques au long cours d'une attitude thérapeutique endoscopique première pour les patients porteurs d'une polypose duodénale avancée (stade IV).
Oral bisphosphonate use and lung cancer incidence among postmenopausal women
Authors: M.H. Tao, S. Chen, J.L. Freudenheim, J.A. Cauley, K.C. Johnson, X. Mai, G.E. Sarto, H. Wakelee, P. Boffetta, J. Wactawski-Wende
Journal: Annals of Oncology (2018)

BackgroundBisphosphonates are common medications for the treatment of osteoporosis in older populations. Several studies, including the Women's Health Initiative (WHI), have found inverse associations of bisphosphonate use with risk of breast and endometrial cancer, but little is known about its association with other common malignancies. The objective of this study was to evaluate the association of bisphosphonate use on the incidence of lung cancer in the WHI.Patients and methodsThe association between oral bisphosphonate use and lung cancer risk was examined in 151 432 postmenopausal women enrolled into the WHI in 1993–1998. At baseline and during follow-up, participants completed an inventory of regularly used medications including bisphosphonates.ResultsAfter a mean follow-up of 13.3 years, 2511 women were diagnosed with incident lung cancer. There was no evidence of a difference in lung cancer incidence between oral bisphosphonate users and never users (adjusted hazard ratio = 0.91; 95% confidence intervals, 0.80–1.04; P = 0.16). However, an inverse association was observed among those who were never smokers (hazard ratio = 0.57, 95% confidence interval, 0.39–0.84; P < 0.01).ConclusionIn this large prospective cohort of postmenopausal women, oral bisphosphonate use was associated with significantly lower lung cancer risk among never smokers, suggesting bisphosphonates may have a protective effect against lung cancer. Additional studies are needed to confirm our findings.
ENDOSCOPIC SLEEVE GASTROPLASTY IS SAFE AND EFFECTIVE IN MORBID OBESITY
Authors: I Boškoski, V Bove, R Landi, F Mangiola, L Laterza, G Gibiino, A Tringali, P Familiari, V Perri, G Costamagna
Journal: Endoscopy (2018)

Obesity has a high impact on the development of the most prevalent chronic conditions (cardiovascular disease, type-II diabetes, etc.). Endoscopic sleeve gastroplasty (ESG) is a new endoscopic technique for the treatment of morbid obesity.
USEFULNESS AND EFFICACY OF RETROFLEXION IN THE ASCENDING COLON DURING COLONOSCOPY
Authors: S Michopoulos, G Axiaris, E Manios, M Stoupaki, V Gagari, G Leonidakis, E Zampeli, I Serafentinidis, H Koroboki, K Petraki, M Sotiropoulou
Journal: Endoscopy (2018)

Missing polyps in the ascending colon during colonoscopy is considered as a main factor for interval cancer appearance.
ACSL5 genotype influence on fatty acid metabolism: a cellular, tissue, and whole-body study
Authors: Abishankari Rajkumar, Awa Liaghati, Jessica Chan, Gilles Lamothe, Robert Dent, Éric Doucet, Rémi Rabasa-Lhoret, Denis Prud'homme, Mary-Ellen Harper, Frédérique Tesson
Journal: Metabolism (2018)
A hypothesis study on bionic active noise reduction of auditory organs
Authors: Qing-Qing Jiang, Ning Yu, Shi-Ming Yang
Journal: Military Medical Research (2018)

Noise exposure can lead to hearing loss and multiple system dysfunctions. As various forms of noise exist in our living environments, and our auditory organs are very sensitive to acoustic stimuli, it is a challenge to protect our hearing system in certain noisy environments. Herein, we propose that our hearing organ could serve as a noise eliminator for high intensity noise and enhance acoustic signal processing abilities by increasing the signal-noise ratio. For suprathreshold signals, the hearing system is capable of regulating the middle ear muscles and other structures to actively suppress the sound level to a safe range. To test our hypothesis, both mathematic model analyses and animal model studies are needed. Based on a digital 3D reconstructed model, every structure in the auditory system can be analyzed and tested for its contribution to the process of noise reduction. Products manufactured by this bionic method could be used and verified in animal models and volunteers. By mimicking the noise-reduction effect of the sophisticated structures in the hearing system, we may be able to provide a model that establishes a new active-sound-suppression mode. This innovative method may overcome the limited capabilities of current noise protection options and become a promising possibility for noise prevention.
CONFOCAL LASER ENDOMICROSCOPY IN THE EVALUATION OF GASTRIC ANTRAL VASCULAR ECTASIAS
Authors: A Martínez-Alcalá García, S Suganda, RD Stibolt, L Council, A Mir Ahmed
Journal: Endoscopy (2018)

Gastric antral vascular ectasia (GAVE) can account for up to 4% of non-variceal upper GI bleeding. The diagnosis is often based on endoscopic appearance or histology. Common endoscopic findings include the “watermelon stomach” appearance described as linear erythematous vessels radiating from the pylorus. However, GAVE may also present with a diffuse punctate or nodular pattern. Confirmation of GAVE involves the histologic findings of dilated ectatic vessels of the mucosa and submucosa, vascular thrombosis in the vessels of the lamina propria (fibrin microthrombi), fibromuscular hyperplasia of the lamina propria secondary to edema/congestion and reactive changes of the foveolar epithelium. An immunohistochemical platelet marker, CD61, is found more often in GAVE. Confocal laser endomicroscopy can provide cellular details up to 1000 micrometers from the mucosal surface. In this study, confocal patterns of GAVE were evaluated.
SNARE TIP ANCHOR POLYPECTOMY: A USEFUL TECHNIQUE TO ACHIEVE EN-BLOC RESECTION
Authors: S Budihal, S Sansone, A Parra-Blanco
Journal: Endoscopy (2018)

Flat colonic polyps can be challenging to resect due to difficult position, unstable scope or slipping of the snare. Here we demonstrate a previously reported colonoscopic technique which facilitates easier placement of the snare thereby achieveing en-bloc resection1.
SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS
Authors: Yumin Huang, John Hale, Yaomei Wang, Wei Li, Shijie Zhang, Jieying Zhang, Huizhi Zhao, Xinhua Guo, Jing Liu, Hongxia Yan, Karina Yazdanbakhsh, Gang Huang, Christopher D. Hillyer, Narla Mohandas, Lixiang Chen, Ling Sun, Xiuli An
Journal: Journal of Hematology & Oncology (2018)

SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ringed sideroblasts (RARS), characterized by isolated anemia. SF3B1 mutations have been implicated in the pathophysiology of RARS; however, the physiological function of SF3B1 in erythropoiesis remains unknown. shRNA-mediated approach was used to knockdown SF3B1 in human CD34+ cells. The effects of SF3B1 knockdown on human erythroid cell differentiation, cell cycle, and apoptosis were assessed by flow cytometry. RNA-seq, qRT-PCR, and western blot analyses were used to define the mechanisms of phenotypes following knockdown of SF3B1. We document that SF3B1 knockdown in human CD34+ cells leads to increased apoptosis and cell cycle arrest of early-stage erythroid cells and generation of abnormally nucleated late-stage erythroblasts. RNA-seq analysis of SF3B1-knockdown erythroid progenitor CFU-E cells revealed altered splicing of an E3 ligase Makorin Ring Finger Protein 1 (MKRN1) and subsequent activation of p53 pathway. Importantly, ectopic expression of MKRN1 rescued SF3B1-knockdown-induced alterations. Decreased expression of genes involved in mitosis/cytokinesis pathway including polo-like kinase 1 (PLK1) was noted in SF3B1-knockdown polychromatic and orthochromatic erythroblasts comparing to control cells. Pharmacologic inhibition of PLK1 also led to generation of abnormally nucleated erythroblasts. These findings enabled us to identify novel roles for SF3B1 in human erythropoiesis and provided new insights into its role in regulating normal erythropoiesis. Furthermore, these findings have implications for improved understanding of ineffective erythropoiesis in MDS patients with SF3B1 mutations.
Ligature élastique endoscopique versus béta-bloquant dans la prévention primaire des hémorragies digestives par rupture de varices oesophagiennes: résultats d'une méta-analyse
Authors: Y Duny, JC Valats, I Chaze, N Flori, M Bismuth, JP Daures, P Blanc
Journal: Endoscopy (2009)

Objectif: La ligature élastique endoscopique des varices oesophagiennes (LVO) est de plus en plus souvent proposée dans la prévention primaire des hémorragies digestives (HD) par rupture des varices oesophagiennes (VO). Néanmoins, les béta-bloquants restent le traitement de référence. Cependant, les résultats des essais et des méta-analyses comparant la LVO et les béta-bloquants dans la prévention primaire des HD par rupture de VO sont discordants. Notre objectif a été de réaliser une méta-analyse actualisée.
ENDOSCOPIC SPECTRUM OF SMALL BOWEL GASTROINTESTINAL TUMORS DISCOVERED DURING DOUBLE BALLOON ENTEROSCOPY
Authors: A Martínez-Alcalá García, LC Fry, PT Kröner, S Peter, C Contreraas, K Mönkemüller
Journal: Endoscopy (2018)

Observational, retrospective, consecutive case series of patients with small bowel GIST. The following information was collected: description of all the lesions, pictures, at least 6 biopsies of each case, location of the lesion, indication, procedure time, and instruments used, submucosal injection solutions, complications and follow-up.