tbuckley/cabot-search huggingface dataset:
An alternative approach to identify women at risk for colorectal cancer.
Authors: Amanda S. Bruegl, Bojana Djordjevic, Shannon Neville Westin, Pamela T. Soliman, Amanda C. Brandt, Molly S Daniels, Karen H. Lu, Russell Broaddus
Journal: Journal of Clinical Oncology (2012)

1513 Background: Hereditary colorectal cancer (CRC) is preventable; however, identification of individuals at sufficiently high risk to warrant heightened surveillance is difficult. Lynch Syndrome (LS) is an inherited cancer syndrome due to germline mutation in a DNA mismatch repair gene. For women with LS, the lifetime risk of endometrial cancer (EC) is 64% and CRC is 54%. Fifty percent of women with LS will present with EC or ovarian cancer prior to CRC. Therefore, women with LS associated EC represent an ideal group for CRC prevention. The optimal method to identify women with LS associated EC is not known. The purpose of this study was to determine the utility of Amsterdam II and Society of Gynecologic Oncology (SGO) Criteria (modified Bethesda criteria that use EC as the sentinel cancer) in identifying women with LS associated EC. Our ultimate goal is to identify women at increased risk of CRC. Methods: Immunohistochemistry (IHC) for DNA mismatch repair proteins and MLH1 methylation analyses were used to identify LS associated EC among 388 women. EC was designated as LS if there was loss of mismatch repair protein expression. Absence of MLH1 methylation was required to confirm LS in tumors with MLH1 protein loss. Results: Fifty-nine (15.2%) of the EC patients tested had LS. These patients are summarized in the table. Conclusions: Clinical criteria to detect LS identify 17/59 (29%) - 44/59 (74%) of women who present with EC first. EC with MSH2 loss is most likely to occur in younger women and women with positive family history of EC and CRC, features classically associated with LS. In general, the MSH6 mutation is associated with older age at diagnosis and fewer familial CRCs, however, we found a large number of MLH1 (50%) and PMS2 (86%) cases diagnosed at greater than 50 years with no family history of CRC. Our data suggest that classic clinical screening criteria are inadequate to detect patients with LS who present with EC, potentially missing up to 25% of these patients. [Table: see text]
Carcinoembryonic Antigen for Diagnosis of Colorectal Cancer Recurrence
Authors: Stephanie S. Kim, Timothy R. Donahue, Mark D. Girgis
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analyses of the short- and long-term graft survival after kidney transplantation in Europe between 1986 and 2015
Authors: Maarten Coemans, Caner Süsal, Bernd Döhler, Dany Anglicheau, Magali Giral, Oriol Bestard, Christophe Legendre, Marie-Paule Emonds, Dirk Kuypers, Geert Molenberghs, Geert Verbeke, Maarten Naesens
Journal: Kidney International (2018)
Ramifications of spinal surgeon being found negligent in giving patient heparin too early and leaving her disabled
Authors: Richard Gullan
Journal: BMJ (2018)

We have serious concerns about the potential ramifications of a neurosurgeon being found negligent for giving a patient low molecular weight heparin early after an elective spinal procedure.1

This case happened in 2013, when the medical profession was being severely criticised for unnecessary deaths from preventable thromboembolic complications, an issue shrouded in controversy for many years. Epidural haematomas may cause paralysis, but in most cases …
Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming
Authors: LiWang, ZiqingLiu, ChaoyingYin, HudaAsfour, OliviaChen, YanzhenLi, NenadBursac, JiandongLiu, LiQian
Journal: Circulation Research (2015)

Rationale:Generation of induced cardiac myocytes (iCMs) directly from fibroblasts offers great opportunities for cardiac disease modeling and cardiac regeneration. A major challenge of iCM generation is the low conversion rate of fibroblasts to fully reprogrammed iCMs, which could in part be attributed to unbalanced expression of reprogramming factors Gata4 (G), Mef2c (M), and Tbx5 (T) using the current gene delivery approach. Objective:We aimed to establish a system to express distinct ratios of G, M, T proteins in fibroblasts and determine the effect of G, M, T stoichiometry on iCM reprogramming. Methods and Results:We took advantage of the inherent feature of the polycistronic system and generated all possible combinations of G, M, T with identical 2A sequences in a single transgene. We demonstrated that each splicing order of G, M, T gave rise to distinct G, M, T protein expression levels. Combinations that resulted in higher protein level of Mef2c with lower levels of Gata4 and Tbx5 significantly enh...
Nivolumab-Induced Hemophilia A Presenting as Gastric Ulcer Bleeding in a Patient With NSCLC
Authors: Ryoji Kato, Hidetoshi Hayashi, Keigo Sano, Kohei Handa, Takahiro Kumode, Hiroto Ueda, Tatsuya Okuno, Hisato Kawakami, Itaru Matsumura, Masatoshi Kudo, Kazuhiko Nakagawa
Journal: Journal of Thoracic Oncology (2018)
Corrigendum to “GoldCLIP: Gel-Omitted Ligation-Dependent CLIP” [Genomics Proteomics Bioinformatics 16 (2) (2018) 136–143]
Authors: Jiaqi Gu, Ming Wang, Yang Yang, Ding Qiu, Yiqun Zhang, Jinbiao Ma, Yu Zhou, Gregory J. Hannon, Yang Yu
Journal: Genomics Proteomics & Bioinformatics (2018)
Near‐Infrared II Dye‐Protein Complex for Biomedical Imaging and Imaging‐Guided Photothermal Therapy
Authors: Xiaodong Zeng, Yuling Xiao, Jiacheng Lin, Shanshan Li, Hui Zhou, Jinxia Nong, Guozhen Xu, Hongbo Wang, Fuchun Xu, Junzhu Wu, Zixin Deng, Xuechuan Hong
Journal: Advanced Healthcare Materials (2018)

The development of novel biodegradable and nontoxic fluorophores that integrate diagnosis and therapy for effective cancer treatment has obtained tremendous attention in the past decades. In this report, water-soluble and biocompatible small-molecule near-infrared II (NIR-II) fluorescent dye H2a-4T complexed with fetal bovine serum (FBS) and Cetuximab proteins with excellent optical properties and targeting ability is prepared. High spatial and temporal resolution imaging of hind limb vasculature and the lymphatic system of living mice using H2a-4T@FBS complex is demonstrated in precise NIR-II imaging-guided sentinel lymph node surgery. More importantly, H2a-4T@Cetuximab complex not only exhibits a remarkable cell-killing ability but also achieves highly active tumor targeting efficiency for epidermal growth factor receptor, overexpressing colorectal cancer which is beneficial to in vivo NIR-II fluorescent imaging-guided photothermal therapy of colon tumors. To the best of our knowledge, it is the first time that the concept of light-harvesting complex is exploited for enhancing the NIR-II signals and photothermal energy conversion in molecule-protein complex theranostic agent, making them a promising candidate for future clinical applications in cancer theranostics.
If we accept that poor replication rates are mainstream
Authors: David M. Alexander, Pieter Moors
Journal: Behavioral and Brain Sciences (2018)

Abstract We agree with the authors' arguments to make replication mainstream but contend that the poor replication record is symptomatic of a pre-paradigmatic science. Reliable replication in psychology requires abandoning group-level p- value testing in favor of real-time predictions of behaviors, mental and brain events. We argue for an approach based on analysis of boundary conditions where measurement is closely motivated by theory.
Rethinking the scale up of Integrated Management of Childhood Illness
Authors: Smruti Patel, Jerome Pfaffmann Zambruni, Daniel Palazuelos, Hailemariam Legesse, Ndeye Fatou Ndiaye, Anne Detjen, Samira Aboubaker
Journal: BMJ (2018)

The global community must come together to rethink approaches and translate existing knowledge into action, say Smruti Patel and colleagues
Risk factors associated with early postoperative complications following laparoscopic total gastrectomy: Experience from the Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) group.
Authors: Jingdong Liu, Haojie Li, Gang Zhao, Zekuan Xu, Guoxin Li, Peiwu Yu, Hongyong He, Kuntang Shen, Fenglin Liu, Yihong Sun
Journal: Journal of Clinical Oncology (2017)

e15544 Background: The incidence rate of proximal gastric cancer has been rising steadily, and laparoscopic total gastrectomy (LTG) has been widely adopted. However, the safety of LTG still lacks solid evidence to prove. The aim of this study was to evaluate morbidity and mortality of LTG, and determine the risk factors associated with early postoperative complications. Methods: A retrospective multicenter study was carried out in China, and medical records of 109 gastric cancer patients receiving LTG during September 2014 and June 2016 were retrieved from the database. Patient characteristics, surgical outcomes, and postoperative morbidities and mortalities were analyzed. Results: Morbidity and mortality rates were 22.0% and 0% respectively. Pulmonary infection (13.8%, n = 15) was the most common complication. Most complications were grade II (15.5%, n = 17) according to the Clavien-Dindo classification. Multivariable analysis identified comorbidity, type of reconstruction method (TLTG) were independent risk factors of early postoperative complications. Comorbidity was the only independent risk factor of complications graded more than II. Diabetes mellitus was found correlated with surgical complication in subgroup analysis. Conclusions: LTG is safe and technically feasible in treating gastric cancer. Careful selection of patients without comorbidity and applying laparoscopy-assisted total gastrectomy instead of totally laparoscopic total gastrectomy may decrease postoperative complications.
Response to: ‘Is miR200b-5p a new predictor of lymphoma or associated with lymphocytes infiltrate within salivary glands?’ by Nocturne <i>et al</i>
Authors: Efstathia K Kapsogeorgou, Aristea Papageorgiou, Athanase D Protogerou, Michael Voulgarelis, Athanasios G Tzioufas
Journal: Annals of the Rheumatic Diseases (2018)

We would like to thank Nocturne et al 1 for their comments regarding our paper,2 giving us the opportunity to clarify possible obscurities and signify the predictive value of low miR200b-5p levels in minor salivary glands (MSGs) for the development of lymphoma in primary Sjogren’s syndrome (pSS).

Our findings disclosed that low miR200b-5p levels in MSGs of patients with pSS (1) strongly discriminate patients with SS who will develop or have lymphoma from those who will not, (2) independently predict lymphoma development, (3) are reduced long before the clinical onset of lymphoma, enabling thus, the identification and efficient monitoring of high-risk patients and (4) may have an application in the monitoring of therapeutic response. These findings strongly support the predictive value of miR200b-5p for monitoring lymphoma development in pSS. Furthermore, the simplicity of the detection assay facilitates the easy and reproducible application worldwide.

As addressed in the original manuscript, this new biomarker was found to correlate with several histological, clinical and laboratory parameters previously associated with lymphoma development, including biopsy focus score and infiltration by various types by infiltrating cells.2 Although the later associations …
Sex-specific regulation of collagen I and III expression by 17β-Estradiol in cardiac fibroblasts: role of estrogen receptors
Authors: Elke Dworatzek, Shokoufeh Mahmoodzadeh, Cindy Schriever, Kana Kusumoto, Lisa Kramer, Gabriela Santos, Daniela Fliegner, Yuet-Kin Leung, Shuk-Mei Ho, Wolfram-Hubertus Zimmermann, Susanne Lutz, Vera Regitz-Zagrosek
Journal: Cardiovascular Research (2018)

Abstract Aims Sex differences in cardiac fibrosis point to the regulatory role of 17β-Estradiol (E2) in cardiac fibroblasts (CF). We, therefore, asked whether male and female CF in rodent and human models are differentially susceptible to E2, and whether this is related to sex-specific activation of estrogen receptor alpha (ERα) and beta (ERβ). Methods and results In female rat CF (rCF), 24 h E2-treatment (10−8 M) led to a significant down-regulation of collagen I and III expression, whereas both collagens were up-regulated in male rCF. E2-induced sex-specific collagen regulation was also detected in human CF, indicating that this regulation is conserved across species. Using specific ERα- and ERβ-agonists (10−7 M) for 24 h, we identified ERα as repressive and ERβ as inducing factor in female and male rCF, respectively. In addition, E2-induced ERα phosphorylation at Ser118 only in female rCF, whereas Ser105 phosphorylation of ERβ was exclusively found in male rCF. Further, in female rCF we found both ER bound to the collagen I and III promoters using chromatin immunoprecipitation assays. In contrast, in male rCF only ERβ bound to both promoters. In engineered connective tissues (ECT) from rCF, collagen I and III mRNA were down-regulated in female ECT and up-regulated in male ECT by E2. This was accompanied by an impaired condensation of female ECT, whereas male ECT showed an increased condensation and stiffness upon E2-treatment, analysed by rheological measurements. Finally, we confirmed the E2-effect on both collagens in an in vivo mouse model with ovariectomy for E2 depletion, E2 substitution, and pressure overload by transverse aortic constriction. Conclusion The mechanism underlying the sex-specific regulation of collagen I and III in the heart appears to involve E2-mediated differential ERα and ERβ signaling in CFs.
Effect of gender on age-specific effects for ulcerated malignant melanomas.
Authors: Blakely S. Richardson, William F. Anderson, Jill Barnholtz-Sloan, Margaret A. Tucker, Meg R. Gerstenblith
Journal: Journal of Clinical Oncology (2012)

1603 Background: Gender, age at diagnosis, and ulceration are all independent prognostic factors for melanoma. The purpose of this study was to further examine the interactions among gender, age, and melanoma ulceration. Methods: Using the NCI’s SEER 17 Registries Database (2004-2008), we assessed ulceration status among White men and women with malignant melanoma, stratified by younger (ages 10-39 years) and older (ages 40-84 years) ages at diagnosis as well as by tumor depth. The analysis was restricted to melanomas common to both age groups, i.e. superficial spreading, nodular, and unclassified melanomas. There were 2905 older men, 301 younger men, 1624 older women and 276 younger women that fit our criteria. Relative risks were expressed as incidence rate ratios (IRR) with 95% confidence intervals (CI). Results: At every tumor depth, IRRs for ulcerated melanomas were significantly higher for older than younger persons (IRR&gt;1.0). The trend, however, was different in men as compared to women. In men, the IRR (older to younger) rose continuously with increasing depth [≤1.0mm: IRR 7.81 (CI 6.18-9.98), 1.01mm-≤2.0mm: IRR 9.71 (CI 7.55-12.68), 2.01mm-≤4.0mm: IRR 11.04 (CI 8.78-14.06); and ≥4.01mm: IRR 12.26 (CI 9.60-15.87)]. On the other hand, in women, IRR (older to younger) was stable for all depths ≤4.0mm then nearly doubled for melanomas ≥4.01mm [≥4.01mm: IRR 8.00 (CI 5.85-11.20)]. The IRR trend analysis was statistically significant for men (p = 0.01) but not for women (p = 0.34). Conclusions: Our study confirms that older age at diagnosis is associated with higher incidence rates of ulcerated malignant melanomas. This large-scale population-based analysis also shows an effect modification by gender and tumor thickness, suggesting different biologic behavior in melanoma in younger and older men and women. Future studies should further investigate tumor biology differences in these populations and the interactions among gender, age at diagnosis, and ulceration in melanoma.
The Purported Procurement Priority of Lifesaving Organs Over Non-Lifesaving Organs: Uterus Transplants and the Ethical Importance of Potential Lives
Authors: Gerard Vong
Journal: The American Journal of Bioethics (2018)

"The Purported Procurement Priority of Lifesaving Organs Over Non-Lifesaving Organs: Uterus Transplants and the Ethical Importance of Potential Lives." The American Journal of Bioethics, 18(7), pp. 25–26
ASK1 contributes to fibrosis and dysfunction in models of kidney disease
Authors: John T. Liles, Britton K. Corkey, Gregory T. Notte, Grant R. Budas, Eric B. Lansdon, Ford Hinojosa-Kirschenbaum, Shawn S. Badal, Michael Lee, Brian E. Schultz, Sarah Wise, Swetha Pendem, Michael Graupe, Laurie Castonguay, Keith A. Koch, Melanie H. Wong, Giuseppe A. Papalia, Dorothy M. French, Theodore Sullivan, Erik G. Huntzicker, Frank Y. Ma, David J. Nikolic-Paterson, Tareq Altuhaifi, Haichun Yang, Agnes B. Fogo, David G. Breckenridge
Journal: Journal of Clinical Investigation (2018)

Oxidative stress is an underlying component of acute and chronic kidney disease. Apoptosis signal–regulating kinase 1 (ASK1) is a widely expressed redox-sensitive serine threonine kinase that activates p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase kinases, and induces apoptotic, inflammatory, and fibrotic signaling in settings of oxidative stress. We describe the discovery and characterization of a potent and selective small-molecule inhibitor of ASK1, GS-444217, and demonstrate the therapeutic potential of ASK1 inhibition to reduce kidney injury and fibrosis. Activation of the ASK1 pathway in glomerular and tubular compartments was confirmed in renal biopsies from patients with diabetic kidney disease (DKD) and was decreased by GS-444217 in several rodent models of kidney injury and fibrosis that collectively represented the hallmarks of DKD pathology. Treatment with GS-444217 reduced progressive inflammation and fibrosis in the kidney and halted glomerular filtration rate decline. Combination of GS-444217 with enalapril, an angiotensin-converting enzyme inhibitor, led to a greater reduction in proteinuria and regression of glomerulosclerosis. These results identify ASK1 as an important target for renal disease and support the clinical development of an ASK1 inhibitor for the treatment of DKD.
Tickborne Diseases — Confronting a Growing Threat
Authors: Catharine I. Paules, Hilary D. Marston, Marshall E. Bloom, Anthony S. Fauci
Journal: New England Journal of Medicine (2018)

Tickborne Diseases The burden of tickborne diseases is growing substantially and seems likely to continue to do so. Prevention and management are hampered by suboptimal diagnostics, lack of treatment options for emerging viruses, and a paucity of vaccines.
Comparison of Perioperative Outcomes Between Cytoreductive Radical Prostatectomy and Radical Prostatectomy for Nonmetastatic Prostate Cancer
Authors: Felix Preisser, Elio Mazzone, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Michele Marchioni, Thomas Steuber, Fred Saad, Francesco Montorsi, Shahrokh F. Shariat, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I. Karakiewicz
Journal: European Urology (2018)
For Survivors of Intimate Partner Violence, Overlooked Brain Injuries Take a Toll
Authors: Rebecca Voelker
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictive Value of Fetal Pulmonary Venous Flow Patterns in Identifying the Need for Atrial Septoplasty in the Newborn With Hypoplastic Left Ventricle
Authors: ErikMichelfelder, CarlenGomez, WilliamBorder, WilliamGottliebson, CheriFranklin
Journal: Circulation (2005)

Background— Pulmonary venous Doppler (PVD) flow patterns in the fetus with hypoplastic left heart syndrome (HLHS) have been correlated with restrictive interatrial communication or intact atrial septum (RAS) postnatally; however, the ability of PVD to identify the neonate requiring emergent atrial septoplasty (EAS) for severe left atrial hypertension and hypoxemia has not been critically evaluated. It was the purpose of this study to determine the predictive power of fetal PVD in identifying the need for EAS in newborns with HLHS and RAS. Methods and Results— Forty-one patients with fetal PVD flow analysis and postnatally confirmed HLHS were studied. Pulsed-wave assessment of PVD flow included S-, D-, and A-wave velocity, time-velocity integral (VTI) of forward and reverse flow, and S/D velocity and forward/reverse VTI ratio. Neonatal EAS was used as the primary clinical outcome variable. Receiver operating characteristic curves were used to determine cutpoints at which PVD indices best predicted EAS. Cut...
Association of iron status with the risk of bloodstream infections: results from the prospective population-based HUNT Study in Norway
Authors: Randi Marie Mohus, Julie Paulsen, Lise Gustad, Åsa Askim, Arne Mehl, Andrew T. DeWan, Jan Egil Afset, Bjørn Olav Åsvold, Erik Solligård, Jan Kristian Damås
Journal: Intensive Care Medicine (2018)