tbuckley/cabot-search huggingface dataset:
Sarcopenia—A New Frontier in the Management Care of Patients With Borderline Resectable Pancreatic Cancer
Authors: Oonagh Griffin, Kevin C. Conlon
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Chronic liver damage causes a reduction in the number and a dysfunction of the activity of liver resident macrophages
Authors: E. Pose, M. Coll, B. Surewaard, Z. Zeng, D. Blaya, L. Perea, B. Aguilar-Bravo, J. Vallverdú, I. Graupera, P. Sancho-Bru, P. Kubes, P. Ginès
Journal: Journal of Hepatology (2018)
ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade
Authors: Jianfeng Shen, Zhenlin Ju, Wei Zhao, Lulu Wang, Yang Peng, Zhongqi Ge, Zachary D. Nagel, Jun Zou, Chen Wang, Prabodh Kapoor, Xiangyi Ma, Ding Ma, Jiyong Liang, Shumei Song, Jinsong Liu, Leona D. Samson, Jaffer A. Ajani, Guo-Min Li, Han Liang, Xuetong Shen, Gordon B. Mills, Guang Peng
Journal: Nature Medicine (2018)
Outcome of bacterial infections complicated or not by acute-on-chronic liver failure in patients with cirrhosis admitted to hospital for acute decompensation
Authors: M. Bartoletti, M. Baldassarre, M. Domenicali, M. Rinaldi, M. Giannella, R. Lewis, M. Tufoni, G. Zaccherini, M. Tamé, L. Napoli, R.M. Pavarin, S. Berardi, G. Ballardini, M. Bernardi, P. Viale, P. Caraceni
Journal: Journal of Hepatology (2018)
Annals Story Slam - To Be or Not to Be: The Doctor Daughter
Authors: Meghna Desai
Journal: Annals of Internal Medicine (2018)

Web Exclusives17 April 2018Annals Story Slam - To Be or Not to Be: The Doctor DaughterFREEMeghna Desai, MDMeghna Desai, MDSIU Medicine, Springfield, Illinois (M.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W18-0007 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - To Be or Not to Be: The Doctor Daughter "To Be or Not to Be: The Doctor Daughter," by Dr. Meghna Desai (Duration 5:28)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: SIU Medicine, Springfield, Illinois (M.D.)Corresponding Author: Meghna Desai, MD; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 April 2018Volume 168, Issue 8Page: SS1 ePublished: 17 April 2018 Issue Published: 17 April 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.Loading ...
Abstract 15020: Transcriptomic and Epigenomic Resemblance of Terminally Differentiated Cells Derived From Isogenic Human iPSCs and Nuclear Transfer Derived ESCs
Authors: Ming-Tao Zhao, Haodong Chen, Qing Liu, Nazish Sayed, Ning-Yi Shao, Youngkyun Kim, Huaxiao Yang, Tony Chour, Hong Ma, Rebecca Tippner-Hedges, Shoukhrat Mitalipov, Michael Snyder, Joseph Wu
Journal: Circulation (2016)

Human pluripotent stem cells (PSCs) hold great promise for disease modeling, drug discovery, and regenerative medicine. Currently, patient-specific PSCs can be created via two approaches: somatic cell nuclear transfer (SCNT) by enucleated oocytes and iPSC reprogramming by ectopic expression of four transcription factors. Recent studies suggest that human SCNT-derived embryonic stem cells (nt-ESCs) are more similar to in vitro fertilized embryo derived ESCs (IVF-ESCs) than iPSCs at both transcriptomic and epigenomic levels. As terminally differentiated cells (i.e., cardiomyocytes, hepatocytes, neurons, and endothelial cells) are mostly desired for clinical application of human PSCs, here we assessed the molecular and functional similarity of terminally differentiated cells derived from human isogenic iPSCs and nt-ESCs. We differentiated three types of PSCs (iPSCs, nt-ESCs, and IVF-ESCs) into beating cardiomyocytes (PSC-CMs) and functional endothelial cells (PSC-ECs), respectively. During the process of induced differentiation, human nt-ESCs displayed closer dynamic marker gene expression profiles to IVF-ESCs than iPSCs. However, terminally differentiated cells (CMs and ECs) derived from iPSCs and nt-ESCs showed comparable differentiation efficiency, lineage marker gene expression, heterogeneity, nitric oxide release and tube formation capacity. Furthermore, iPSC-CMs were clustered more closely to nt-ESC-CMs than IVF-ESC-CMs at transcriptional level revealed by RNA-seq. DNA methylome analysis by RRBS-seq indicated that iPSC-CMs and iPSC-ECs were epigenetically similar to nt-ESC-CMs and nt-ESC-ECs, respectively, but were distinguishable from IVF-ESC derivatives. Thus, for generating terminally differentiated cells, human iPSCs are comparable to their isogenic nt-ESCs with respect to transcriptomic, epigenomic, and functional features.
Review: Adding clopidogrel to ASA reduces CV morbidity but increases bleeding in patients at high risk for CV events
Authors: Ellis Lader
Journal: Annals of Internal Medicine (2018)

Source Citation Squizzato A, Bellesini M, Takeda A, Middeldorp S, Donadini MP. Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;12:CD005158. 29240976
Involvement of sphingosine-1P receptor 2 (S1PR2) in taurolithocholate-induced impairment of multidrug resistence-associated protein 2 (Mrp2) in rat
Authors: R. Andermatten, N. Ciriaci, M.V. Razori, G. Miszczuk, I. Barosso, E.S. Pozzi
Journal: Journal of Hepatology (2018)
Abstract 14292: Living Heart Human Model: Pacemaker Lead Insertion and Cardiac Cycle Simulation
Authors: Prabhav Saraswat, Karl D'Souza, Brian P Baillargeon
Journal: Circulation (2015)

Introduction: The durability of the pacemaker electrodes is of great importance since damage to them can mean they no longer provide life-saving electrical stimulus. A pacemaker electrode is meant to be a permanent implant, where it is expected to perform for many years without failure. The SIMULIA Living Heart Human Model provides a unique testing environment where a pacemaker electrode can be virtually inserted and mechanically deformed during the cardiac cycle. The virtual nature of the test provides a physiologically accurate methodology to test new and existing devices without exposing patients to un-necessary risk. Further, the computational model allows for hundreds of virtual experiments, where parameters such as lead diameter, stiffness and location are varied to select the design and placement that have optimal reliability Methods: The SIMULIA Living Heart Human Model is a high-fidelity multiphysics finite element model of a healthy, 4-chamber adult human heart and proximal vasculature. The pacemaker lead was inserted into the right atrium and ventricle through the superior vena cava. The heart model then completes 3 cardiac cycles to determine the deformation of the electrode. Results: The primary mode of deformation to cause damage is bending; therefore, curvature change of the pacemaker electrode is the output quantity of primary interest. The plot below shows the curvature (left) and maximum alternating curvature (right) along the length of the pacemaker electrode throughout the cardiac cycle. Conclusions: The results demonstrate the feasibility of utilizing a high-fidelity heart model to estimate the amount of deformation experienced by a pacemaker electrode during the cardiac cycle. This work, coupled with empirical fatigue testing of the implant, will allow for durability calculations to be made of existing and new electrode designs.
Basic and translational research in the <i>European Respiratory Journal</i>
Authors: Ramon Farré, Pieter S. Hiemstra, Anh Tuan Dinh-Xuan
Journal: European Respiratory Journal (2018)

<b>The proportion of papers on basic science published in the <i>European Respiratory Journal</i> has decreased in recent years, but those published have similar citation rates to papers dealing with clinical research</b>http://ow.ly/2SW230jptQR
P456Xanthine oxidase suppression mediates anti-oxidative effect of somatic nerve stimulation in cardiac IR injury
Authors: K H Lee, H N Cho, S R Lee, SM K Lee, W Kim
Journal: Cardiovascular Research (2018)

Materials and methods of research.The study included 19 patients with primary a STEMI the average age was 59 6 17 years.All patients underwent PCI with reperfusion of the infarctionrelated coronary artery.The mean recanalization time was 5 (4, 6) h.Using EchoCG, final systolic volume (CSR), terminal diastolic volume (BWW), LV ejection fraction (LVEF) was msured admission, 3rd, 7th and 21st day of STEMI.The CD133þ cells level was determined by flow cytometry of venous blood samples in the same periods.There was a control group of healthy volunteers (6 males) the average age was 41 6 9 years (absolutely healthy).Results: Carrying out an individual analysis of CD 133þ cells level circulating in patients with acute myocardial infarction, they found a multidirectional, nonlinear dynamics of their content by the 3rd day of MI.Due to this dynamics, all patients were divided into 2 subgroups: the 1st subgroup consisted of the patients with initially low level and it's further increasing on the 3rd day of MI, the 2nd subgroup -patients with a decrease level to a 3-m day of illness.Intragroup and intergroup differences were revealed on different days of the disease (p <0.05).A positive correlation was established between the relative amount of CD133þ cells in patients of the 2nd subgroup on the 7th day of MI and LVEF on the 21st day (R ¼ 0.7, p ¼ 0.02).Also, a relationship was found between the low absolute amount of CD 133þ cells in the first day of acute myocardial infarction and signs of chronic heart failure (CHF) after 6 months of the disease (p <0.05).Namely: in patients of the first subgroup, 6 months after of acute MI, minimal clinical manifestations of CHF were observed.This fact confirms that a high release of CD133þ cells into the peripheral channel is associated with a favorable course and disease prognosis. Conclusion:We showed the response of marrow to acute myocardial infarction, as release of CD133þ cells into the blood.It was found that the high mobilization of these cells both on the 1st day of MI and during the whole observation period was associated with a favorable course and disease prognosis, according to improvement of clinical and echocardiographic parameters.
Preliminary efficacy and safety of acetyl-CoA carboxylase inhibitor GS-0976 in patients with compensated cirrhosis due to NASH
Authors: S. Harrison, M. Noureddin, R. Herring, P. Ruane, B. Mccolgan, B. Kirby, C. Nelson, R.A. Schall, C. Jia, M. Subramanian, R. Myers, M. Middleton, C. Sirlin, M. Fitch, K. LI, M. Hellerstein, E. Lawitz
Journal: Journal of Hepatology (2018)
Stimulation of soluble guanylate cyclase inhibited fibrosis and inflammation in human liver microtissues and in an animal model of liver disease
Authors: K. Hall, S. Bernier, S. Jacobson, G. Liu, R. Sarno, V. Catanzano, J. Sheppeck, J. Hadcock, M. Currie, J. Masferrer
Journal: Journal of Hepatology (2018)
Margaret McCartney: Religion must defy the harms of futile medicine
Authors: Margaret McCartney
Journal: BMJ (2018)

Doctors are “murderers,” the UK has “death panels,” and the plight of Alfie Evans and his family shows why we say we need guns to protect us from the government.1 Social media in the age of fake news can be dangerous. This becomes more bizarre when tethered to the view, especially from the far right and self identified Christians in the US, that Alder Hey Hospital is committing a heinous crime. Catholicism in particular was behind pleas for more, non-palliative, intervention in the life of Alfie Evans, a baby with a fatal illness who has now died.

I went to a Catholic state school, a common destination for children my age brought up in Scotland. I …
P258Hypoxia activates stem cells in myocardial tissue
Authors: P Dokshin, A Karpov, S H Eyvazova, A Malashicheva
Journal: Cardiovascular Research (2018)

Background/Introduction: Telomeres are dynamic chromosome-end structures that protect DNA in our genome from deterioration.Throughout life, telomere lengths (TLs) become shorter, and the rate of this process has been associated with lifestyle and the onset of age-related diseases.Moreover, the aging-associated factor growth differentiation factor 11 (GDF11) has been suggested as a rejuvenating factor.Together, the interplay of these aspects that possibly modulate the aging process is of interest to explore.Purpose: To investigate the associations between leukocyte TLs (LTLs) and chronological age, comorbidities and clinical outcome in patients with coronary artery disease (CAD).Potential covariations between LTL and GDF11 were further assessed.Methods: 300 patients with stable CAD, 20% female, age range 36-81 yrs, were included.Within 2 years, a composite of new clinical events (unstable angina pectoris, myocardial infarction (MI), stroke and deaths) was recorded.DNA and RNA were isolated from whole blood for the analysis of LTLs and GDF11 gene expression, respectively.LTLs were measured by PCR using telomerespecific primers and determined relatively to a single copy gene (36B4).The amount of GDF11 was measured as relative quantification using PCR and the house-keeping gene b2M.Results: We observed that patients with previously suffered MI presented with 20% shorter LTLs vs. patients without (p ¼ 0.015), however, only in men (p ¼ 0.009, n ¼ 115).To further explore this association, LTLs were divided into quartiles (Qs) and further dichotomized at the distinctive cut-off level between Q3 and Q4.LTLs in the upper Q were associated with 60% lower frequency of having suffered a previous MI (p ¼ 0.008, adjusted for age, treated hypertension, body mass index (BMI), triglycerides, HDL and fasting glucose).LTLs were not differently distributed according to sex or the presence of treated hypertension (52%), diabetes type 2 (25%), metabolic syndrome (35%) and clinical outcome (12%).In the total cohort, LTLs were further inversely correlated to age (r ¼ -0.17, p ¼ 0.007), however, only in women (r ¼ -0.37, p ¼ 0.006).In all subjects, GDF11 gene-expression was weakly and inversely correlated to age (r ¼ -0.16, p ¼ 0.010).Overall, no correlation was observed between LTLs and gene-expression of GDF11.However, when dividing into subgroups, a strong correlation was observed in overweight women (BMI > 25), (r ¼ 0.40, p ¼ 0.028).Conclusions: Although no association between LTLs and clinical outcome was observed, LTLs correlated to the severity of CAD in men, in this case previously suffered MI.In women, LTLs seem to be more associated with age.The results may indicate gender-related differences in regulatory mechanisms of TLs and a possible metabolically influenced association between LTLs and GDF11.
The Shortage of Normal Saline in the Wake of Hurricane Maria
Authors: Chana A. Sacks, Aaron S. Kesselheim, Michael Fralick
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Association of plexiform neurofibroma volume changes and development of clinical morbidities in neurofibromatosis 1
Authors: Andrea M Gross, Gurbani Singh, Srivandana Akshintala, Andrea Baldwin, Eva Dombi, Somto Ukwuani, Anne Goodwin, David J Liewehr, Seth M Steinberg, Brigitte C Widemann
Journal: Neuro-Oncology (2018)

Plexiform neurofibromas (PN) in neurofibromatosis 1 (NF1) can cause substantial morbidities. Clinical trials targeting PN have recently described decreases in PN volumes. However, no previous study has assessed the association between changes in PN volumes and PN-related morbidities. Our objective was to assess if increasing PN volume in NF1 is associated with increasing PN-related morbidity.This is a retrospective review of patients enrolled on the NCI NF1 natural history study with ≥7 years of data available. Morbidities including pain, motor dysfunction, vision loss, and PN-related surgery were assessed at time of baseline PN MRI with volumetric analysis and time of MRI with maximum PN volume.Forty-one patients (median age at baseline 8 y) with 57 PN were included. At baseline, 40 PN had at least 1 PN-associated morbidity. During the observation period, 27 PN required increasing pain medication, and these PN grew faster per year (median difference 8.3%; 95% CI: 2.4, 13.8%) than those PN which did not. PN resulting in motor impairment at baseline (n = 11) had larger volumes compared with those that did not (median difference 461 mL; 95% CI: 66.9, 820).Many NF1 PN were associated with clinically significant morbidity at baseline, highlighting the need for longitudinal morbidity evaluations starting at an early age to capture changes in PN-associated morbidities. Prospective evaluation of standardized patient reported and functional outcomes in clinical trials are ongoing and may allow further characterization of the association of PN volume increase or decrease and clinical changes.
Implementation of MenACWY vaccination because of ongoing increase in serogroup W invasive meningococcal disease, the Netherlands, 2018
Authors: Mirjam J Knol, Wilhelmina LM Ruijs, Laura Antonise-Kamp, Hester E de Melker, Arie van der Ende
Journal: Eurosurveillance (2018)

The annual incidence rate of serogroup W invasive meningococcal disease in the Netherlands increased from &lt; 0.05/100,000 (n &lt; 10) before 2015 to 0.5/100,000 (n = 80) in 2017. Most isolates (94%) belong to clonal complex 11. The incidence rate is highest among &lt; 5 year-olds and 15–24 year-olds. The case fatality rate was 12% (17/138) in 2015–2017. From May 2018, MenACWY vaccination replaces MenC vaccination at age 14 months and from October 2018, 13–14 year-olds are offered MenACWY vaccination.
Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation
Authors: Pan Liu, Jan Wysocki, Tomokazu Souma, Minghao Ye, Veronica Ramirez, Bisheng Zhou, Lisa D. Wilsbacher, Susan E. Quaggin, Daniel Batlle, Jing Jin
Journal: Kidney International (2018)
Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease
Authors: Michael F. Egan, James Kost, Pierre N. Tariot, Paul S. Aisen, Jeffrey L. Cummings, Bruno Vellas, Cyrille Sur, Yuki Mukai, Tiffini Voss, Christine Furtek, Erin Mahoney, Lyn Harper Mozley, Rik Vandenberghe, Yi Mo, David Michelson
Journal: New England Journal of Medicine (2018)

Alzheimer's disease is characterized by the deposition of amyloid-beta (Aβ) plaques in the brain. Aβ is produced from the sequential cleavage of amyloid precursor protein by β-site amyloid precursor protein–cleaving enzyme 1 (BACE-1) followed by γ-secretase. Verubecestat is an oral BACE-1 inhibitor that reduces the Aβ level in the cerebrospinal fluid of patients with Alzheimer's disease.
Accuracy of qPCR for quantifying Leishmania kDNA in different skin layers of patients with American tegumentary leishmaniasis
Authors: L. Sevilha-Santos, A.C.M. dos Santos Júnior, V. Medeiros-Silva, J.O. Bergmann, E.F. da Silva, L.F. Segato, A.Y.M. Arabi, N.A. de Paula, R.N.R. Sampaio, B.D. Lima, C.M. Gomes
Journal: Clinical Microbiology and Infection (2018)
Correlation between controlled attenuation parameter assessed with Fibroscan and steatosis percent objectively quantified from the entire liver biopsy specimen using a computer analysis tool: Preliminary results
Authors: M. Lupsor-Platon, G. Bianca, A. Maniu, V. Cristian, R. Ioana, H. Stefanescu, U. Radu, A.H. Nadim
Journal: Journal of Hepatology (2018)
P94Pregnancy associated plasma protein A an insulin-like growth factor-1 in acute coronary pathology
Authors: G Kayumova, V Razin
Journal: Cardiovascular Research (2018)

Introduction: Worldwide deaths from cardio -vascular disease ranks first among all causes of overall mortality.The study of new markers of growth of atherosclerotic plaque and damage opens up new opportunities to reduce acute coronary death.The purpose of the comparative analysis of levels of PAPP-A and IGF-I in the blood plasma in patients with acute coronary syndrome.Material and methods.The study included 71 patients with acute coronary artery disease, the average age of 57 years.The plasma was determined PAPP-A and IGF-I.The blood sampling was performed at admission.The control group of 20 healthy individuals.A comparison group of 40 patients with hypertension and coronary heart disease with stable forms.Results: PAPP-A infarction acute phase STEMI was the highest 27.75611.75and close to the mortality rate for 27.767.1.PAPP-A infarction acute phase non STEMI were slightly below 22.1267.69,but very significantly higher (p<0.05)than in patients with unstable angina-8.2263,16.Increased IGF-I in all cases of myocardial infarction.Nevertheless, compared with PAPP-A, IGF-I infarction acute phase STEMI was 156.53645.31lower than infarction acute phase non STEMI 172.28631.59and unstable angina.The highest concentration of IGF-I unstable angina 179.68644.09.The negative correlation between IGF-I and PAPP-A in the case of death from acute coronary insufficiency -the concentration of IGF-I is the lowest 126.06615.12,while the levels of PAPP-A the highest. Conclusion:The levels of PAPP-A, IGF-I was significantly higher in patients with acute coronary artery disease compared with healthy people and patients with hypertension and coronary heart disease (stable form).PAPP-A and IGF-I are presented as growth factors and damage to protein, and can be used as an analyzer of an atherosclerotic plaque instability of acute coronary events.