tbuckley/cabot-search huggingface dataset:
How Silhouettes Became “Black”: The Visual Rhetoric of the Harlem Renaissance
Authors: Brunet, François
Journal: Circulation (2017)

How Silhouettes Became "Black": The Visual Rhetoric of the Harlem RenaissanceFrank MehringCirculationSilhouettes confront us in our daily encounters with new digital media, advertisements, computer games, and films. They appear in the outline of company logos on smartphones and iPads, and on movie posters and advertisements in global urban environments. They remind us of the iconic Bat-Signal in the DC Comics series and the silhouetted credit sequences by Maurice...AuthorFrank MehringPublisherTerra Foundation for American ArtCopyright© 2017, Terra Foundation for American ArtRelated print edition pages: pp.180-216 https://doi.org/10.37862/aaeportal.00191.006 Stable URL: https://aaeportal.com/?id=-19916Copy Chapter subject tags:Harlem RenaissanceSilhouettesDouglas, AaronReiss, Winold, 1886-1953Walker, Kara Elizabeth
Mismatch repair participates in an error-free repair of psoralen crosslinks in human cells.
Authors: Qi Wu, Laura A. Christensen, Kelsey E. Gray, Karen M. Vasquez
Journal: Cancer Research (2004)

2278  Psoralen is a bifunctional crosslinking agent that can form DNA interstrand crosslinks (ICLs) following exposure to UVA irradiation. ICLs present a formidable block to DNA metabolism and must be repaired for cell survival. Crosslinking agents are both beneficial and detrimental to human health, as they are used in the treatment of human disease, yet they are also known to induce mutagenesis, which may lead to tumorigenesis. In bacteria, the repair of ICLs is performed primarily by nucleotide excision repair (NER) and homologous recombination (HR). However little is known about the repair of ICLs in mammalian cells. We and others have demonstrated previously that NER is involved in an error-prone repair of triplex-directed psoralen ICLs. Recently it has been reported that mismatch repair (MMR) proteins are involved in the removal of psoralen ICLs in human cell extracts. Here we show for the first time, that MMR is involved in an error-free repair of triplex-directed ICLs in human cells. Because NER is involved in an error-prone repair of triplex-directed ICLs, we hypothesized that MMR may be involved in an error-free repair of these lesions. To test this hypothesis, we used psoralen-conjugated triplex-forming oligonucleotides to target ICLs to a specific site in a mutation reporter plasmid. Binding assays demonstrated that human MSH2-3 specifically bound the psoralen ICLs with high affinity. We performed DNA repair assays to compare the processing of the lesion in MMR-deficient and -proficient human cell extracts. The DNA repair synthesis level was greatly reduced in the MMR-deficient extracts, suggesting that MMR plays a critical role in the processing of ICLs. To determine the nature of the MMR repair, we subjected ICL-damaged plasmids to a mutagenesis assay in MMR-deficient and -proficient human cell lines. The mutation frequencies were similarly high in both MMR-deficient and -proficient human cells. These results indicate that the MMR proteins do not participate in the error-prone repair of ICLs. Taken together, our findings suggest that human MMR proteins can recognize triplex-directed psoralen ICLs and participate in an error-free repair of this complex lesion in human cells. Thus it may be possible to sensitize a cell to repair a triplex-directed psoralen ICL in an error-free fashion by regulating the function of these proteins.
Screening for Severe Combined Immunodeficiency on the Ohio Newborn Screen Using TREC Analysis: Experience from the First Four Years
Authors: David E. Tapke, Benjamin Prince, Peter Mustillo, Sherman Alter, Rosemary Hage, Leigh Ann A. Kerns, Sharon Linard, Rebecca A. Marsh, Kimberly A. Risma, Nancy Wasserbauer, Rebecca Scherzer
Journal: Journal of Allergy and Clinical Immunology (2018)
Complete Revascularization for Percutaneous Coronary Intervention
Authors: William S. Weintraub
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
La surveillance de la listériose en Finlande entre 1995-2004
Authors: O Lyytikäinen, U M Nakari, S Lukinmaa, E Kela, N Nguyen Tran Minh, A Siitonen
Journal: Eurosurveillance (2006)

L’analyse des donnees de surveillance des cas de listeriose declares au Registre national finlandais des maladies infectieuses entre 1995 et 2004 et la description de nos experiences recentes d’investigation de clusters de cas de listeriose sont presentees dans l’article suivant. Le nombre annuel de cas variait entre 18 et 53, sans tendance notable d’incidence (incidence annuelle moyenne : 7 cas par million d’habitants). Seul un nombre reduit de cas etait associe a des femmes enceintes ou a des nouveaux-nes. La plupart des patients etaient des personnes âgees presentant des pathologies sous-jacentes de forme benigne ; 25% d’entre elles sont decedees suite a ces infections. Plusieurs clusters ont ete detectes au moyen du serotypage et du genotypage des isolats de listeria effectues en routine. Le vehicule de l’infection n’a ete identifie que dans deux epidemies. Un quart au moins des cas de listeriose (78/315) etait du a un sero-genotype specifique ou a des genotypes etroitement lies, trouves egalement dans des produits de la mer fumes ou sales a froid emballes sous vide. Au cours de la periode 2000-2003, les consommateurs finlandais ont ete informes a plusieurs reprises des recommandations sur l’alimentation des groupes a risques. Ces campagnes d’information ciblaient egalement les medecins traitants et les maternites.
Liver‐specific deficiency of unc‐51 like kinase 1 and 2 protects mice from acetaminophen‐induced liver injury
Authors: Yu Sun, Terytty Yang Li, Lintao Song, Cixiong Zhang, Jingyi Li, Zhi‐Zhong Lin, Sheng‐Cai Lin, Shu‐Yong Lin
Journal: Hepatology (2017)

unc-51-like autophagy activating kinase 1 and 2 (Ulk1/2) regulate autophagy initiation under various stress conditions. However, the physiological functions of these Ser/Thr kinases are not well characterized. Here, we show that mice with liver-specific double knockout (LDKO) of Ulk1 and Ulk2 (Ulk1/2 LDKO) are viable, but exhibit overt hepatomegaly phenotype. Surprisingly, Ulk1/2 LDKO mice display normal autophagic activity in hepatocytes upon overnight fasting, but are strongly resistant to acetaminophen (APAP)-induced liver injury. Further studies revealed that Ulk1/2 are also dispensable for APAP-induced autophagy process, but are essential for the maximum activation of c-Jun N-terminal kinase (JNK) signaling both in vivo and in isolated primary hepatocytes during APAP treatment. Mechanistically, APAP-induced inhibition of mechanistic target of rapamycin complex 1 releases Ulk1 from an inactive state. Activated Ulk1 then directly phosphorylates and increases the kinase activity of mitogen-activated protein kinase kinase 4 and 7 (MKK4/7), the upstream kinases and activator of JNK, and mediates APAP-induced liver injury. Ulk1-dependent phosphorylation of MKK7 was further confirmed by a context-dependent phosphorylation antibody. Moreover, activation of JNK and APAP-induced cell death was markedly attenuated in Mkk4/7 double knockdown hepatocytes reconstituted with an Ulk1-unphosphorylatable mutant of MKK7 compared to those in cells rescued with wild-type MKK7.Together, these findings reveal an important role of Ulk1/2 for APAP-induced JNK activation and liver injury, and understanding of this regulatory mechanism may offer us new strategies for prevention and treatment of human APAP hepatotoxicity. (Hepatology 2018;67:2397-2413).
Abstract 17942: Identifying Heart Failure Patients Less Likely to Report Dyspnea
Authors: Corrine Y Jurgens, Ruth M Masterson Creber, Christopher S Lee
Journal: Circulation (2016)

Background: Dyspnea is a hallmark symptom of heart failure (HF); yet, many patients living with HF do not experience this symptom. Purpose: The purpose of the study was to identify clinical and psy...
Abstract 12103: Vascular Function Affects Aortic Root Dilatation in Patients After Fontan Procedure
Authors: Seiji Asagai, Kei Inai, Gen Harada, Mikiko Shimizu, Tetsuko Ishii, Tokuko Shinohara, Hisashi Sugiyama, Hifofumi Tomimatsu, In-Sam Park
Journal: Circulation (2016)

Introduction: It is well known that, in patients with congenital heart disease, such as Tetralogy of Fallot, aortic root dilatation may gradually progress. Similar phenomenon also occur in patients with single ventricle circulation. However, the factors associated with aortic dilatation in these patients are still unknown. Hypothesis: We assessed the hypothesis that vascular function associated with the aortic root dilatation after Fontan procedure. Methods: Between July 2013 and April 2016, sixty-one patients who underwent the Fontan procedure (age, 12.8–55.8 years; median age, 23.2 years; postoperative duration, 8.2-31.3 years; median postoperative duration, 16.8 years) were enrolled. These patients were divided into 2 groups according to the presence or absence of aortic root dilatation and analyzed the relation between aortic root size and clinical profile, vascular function, hemodynamics, and neurohormonal factors. Aortic root dilatation was defined as observed/expected aortic root diameter &gt;1.5 (aortic root dilatation, n=15, aortic root non-dilatation, n=46). Results and Conclusions: Age at Fontan procedure was significantly higher in the dilatation group than in the non-dilatation group (10.5±7.3 vs 5.3±4.0, P&lt;0.01). FMD was significantly lower in the dilatation group than in the non-dilatation group (5.9±1.4 vs 8.3±2.3, OR 0.49, 95%CI 0.28-0.74, P&lt;0.0001). Pulse wave velocity (PWV) was significantly higher in the dilatation group than in the non-dilatation group (1081±277 vs 943±140, P&lt;0.05). Although hemodynamic variables and neurohormonal factors was not associated with aortic root size, pulmonary atresia was associated with aortic root dilatation (OR 5.43, 95%CI 1.55-20.18, P&lt;0.01). In the multivariate analysis, impaired FMD had a close association with aortic dilatation (OR 0.45, 95%CI 0.19-0.82, P&lt;0.01). FMD showed a negative correlation between age at Fontan procedure, PWV and parameter β(age at Fontan procedure r: -0.56, p&lt;0.0001, PWV r: -0.32, p&lt;0.05, β r: -0.27, p&lt;0.05). We concluded that, in patients after Fontan procedure, vascular dysfunction such as aortic stiffness occurred in the patients who underwent Fontan procedure at older age and may play a role in progressive aortic dilatation.
Abstract 20173: Effects of Pulmonary Vasodilator Therapy on Hemodynamics and Exercise Capacity in Patients With Exercise Induced Pulmonary Hypertension Due to Pulmonary Vascular Disease or Heart Failure With Preserved Ejection Fraction
Authors: David C Ishizawar, Matthew Lander, Michael A Mathier
Journal: Circulation (2014)

Background: Both exercise induced pulmonary arterial hypertension (EIPAH) and early heart failure with preserved ejection fraction (HFpEF) can manifest as exercise induced PH. During exercise testi...
Aside from the Allelic Burden of JAK2-V617F, Acquisition of Mutations in Myeloid Gene Panel Is Associated with the Transformation of Myeloproliferative Neoplasm into Secondary AML
Authors: Meong Hi Son, Taehyung Kim, Jae-Sook Ahn, Marc Tyndel, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Seung-Shin Lee, Seo-Yeon Ahn, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Hee Jeong Park, Seung Hyun Choi, Zhaolei Zhang, Dennis Dong Hwan Kim
Journal: Blood (2016)
Abstract #3296: A mathematical tool to predict the efficacy of nanoparticles for cancer treatment and imaging
Authors: Victor Calo, Thomas Hughes, Mauro Ferrari, Paolo Decuzzi
Journal: Cancer Research (2009)

The purpose of the study is the development of a mathematical model to predict over time the distribution of nanoparticles within the tumor vasculature and the concentration of drug molecules released by the nanoparticles towards the tumor mass. Within the framework of Isogeometric Analysis, the proposed mathematical model analyzes (i) the transport of nanoparticles in the highly permeable and tortuous cancerous microvasculature; (ii) the firm specific and non-specific adhesion of nanoparticles to the vessel walls and (iii) the long term release of drug molecules from the adhered nanoparticles towards the cancerous microenvironment. The transport of nanoparticles is analyzed considering a \#8216;single phase flow\#8217; governed by an advection-diffusion equation, where nanoparticles are treated as passive scalars transported in a Non-Newtonian fluid. At the vessel walls, the Starling law is imposed to account for the vessel permeability and a first order kinetic reaction law is used to predict the rate of nanoparticles adhesion. The adhesive boundary conditions are formulated as a function of the particle characteristic features (size, shape; surface ligand density; surface physico-chemical properties) and of the vascular physiology (wall shear stress; surface density and type of receptors; vascular architecture), following the recent models developed by Decuzzi and Ferrari (2006,2008). The concentration of adhered nanoparticles along the vascular surface is also estimated. The vascular geometry can be directly derived from CT scans of the patient or Intravital Microscopy images of the animal under analysis. The extravascular diffusion of drug molecules released from the adhered nanoparticles is analyzed employing an advection-diffusion equation accounting for the variation of the diffusion coefficient within the tissue and for the contribution of the vessel permeability. The proposed mathematical model is anticipated to constitute an ideal tool for predicting the behavior of nanoparticles and select their optimal formulation (size, shape and surface properties) before injection and, more importantly, as a function of the patient-specific vascular features.  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3296.
Suicide Risk Behaviors Among Sexual Minority Adolescents in the United States, 2015
Authors: Theodore L. Caputi, Davey Smith, John W. Ayers
Journal: JAMA (2017)

Sexual minority (lesbian, gay, bisexual, or questioning) adolescents are believed to have elevated suicide risks. 1 Studies supporting this claim, however, rarely use nationally representative samples, which is a major limitation given that stigma and prevention resources vary across communities and may influence suicide risk behaviors. 2When nationally representative studies are available, they are not recent. 3Moreover, studies have ignored the diversity among sexual minorities, assuming all share the same risks. 4We estimated suicide risk behaviors of sexual minority adolescents using nationally representative data from 2015.
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia
Authors: Maja Rothenberg-Thurley, Susanne Amler, Dennis Goerlich, Thomas Köhnke, Nikola P. Konstandin, Stephanie Schneider, Maria C. Sauerland, Tobias Herold, Max Hubmann, Bianka Ksienzyk, Evelyn Zellmeier, Stefan K. Bohlander, Marion Subklewe, Andreas Faldum, Wolfgang Hiddemann, Jan Braess, Karsten Spiekermann, Klaus H. Metzeler
Journal: Leukemia (2018)

Some patients with acute myeloid leukemia (AML) who are in complete remission after induction chemotherapy harbor persisting pre-leukemic clones, carrying a subset of leukemia-associated somatic mutations. There is conflicting evidence on the prognostic relevance of these clones for AML relapse. Here, we characterized paired pre-treatment and remission samples from 126 AML patients for mutations in 68 leukemia-associated genes. Fifty patients (40%) retained ≥1 mutation during remission at a VAF of ≥2%. Mutation persistence was most frequent in DNMT3A (65% of patients with mutations at diagnosis), SRSF2 (64%), TET2 (55%), and ASXL1 (46%), and significantly associated with older age (p < 0.0001) and, in multivariate analyses adjusting for age, genetic risk, and allogeneic transplantation, with inferior relapse-free survival (hazard ratio (HR), 2.34; p = 0.0039) and overall survival (HR, 2.14; p = 0.036). Patients with persisting mutations had a higher cumulative incidence of relapse before, but not after allogeneic stem cell transplantation. Our work underlines the relevance of mutation persistence during first remission as a novel risk factor in AML. Persistence of pre-leukemic clones may contribute to the inferior outcome of elderly AML patients. Allogeneic transplantation abrogated the increased relapse risk associated with persisting pre-leukemic clones, suggesting that mutation persistence may guide post-remission treatment.
Interventions for Nongenital Molluscum Contagiosum in Persons Without Immune Deficiency
Authors: Johannes C. van der Wouden, Sander Koning, Kenneth A. Katz
Journal: JAMA Dermatology (2017)

<h3>Clinical Question</h3> How effective and safe are treatments for nongenital molluscum contagiosum in persons without immune deficiency? <h3>Bottom Line</h3> Compared with placebo, imiquimod, 5%, cream was not more effective in clearing molluscum contagiosum and caused more local adverse effects, including application site reactions, in children aged 2 to 12 years; because high-quality evidence for other interventions is lacking, allowing for natural resolution of the infection remains a reasonable approach.
Autoantibody profile in treatment naïve Takayasu arteritis patients
Authors: Maja Stojanovic, Sanvila Raskovic, Dragana Jovanovic, Jasna Bolpacic, Aleksandra Peric Popadic, Ivan Rankovic, Vladimir Milivojevic, Mirjana Bogic
Journal: Journal of Allergy and Clinical Immunology (2018)
Migration, TB control and elimination: Whom to screen and treat
Authors: A. Rendon, R. Centis, J.-P. Zellweger, I. Solovic, C.A. Torres-Duque, C. Robalo Cordeiro, F.C. de Queiroz Mello, D. Manissero, G. Sotgiu
Journal: Pulmonology (2017)

Tuberculosis (TB) in migrants represents an important clinical and public health threat, particularly in low TB incidence countries. The current review is aimed to assess issues related to screening and treatment of migrants with latent TB infection or TB disease.
Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4–MMP1 axis
Authors: Eunjeong Kim, Donghyo Kim, Jeon‐Soo Lee, Jeehyun Yoe, Jongmin Park, Chang‐Jin Kim, Dongjun Jeong, Sanguk Kim, Yoontae Lee
Journal: Hepatology (2017)

Hepatocellular carcinoma (HCC) is developed by multiple steps accompanying progressive alterations of gene expression, which leads to increased cell proliferation and malignancy. Although environmental factors and intracellular signaling pathways that are critical for HCC progression have been identified, gene expression changes and the related genetic factors contributing to HCC pathogenesis are still insufficiently understood. In this study, we identify a transcriptional repressor, Capicua (CIC), as a suppressor of HCC progression and a potential therapeutic target. Expression of CIC is posttranscriptionally reduced in HCC cells. CIC levels are correlated with survival rates in patients with HCC. CIC overexpression suppresses HCC cell proliferation and invasion, whereas loss of CIC exerts opposite effects in vivo as well as in vitro . Levels of polyoma enhancer activator 3 (PEA3) group genes, the best‐known CIC target genes, are correlated with lethality in patients with HCC. Among the PEA3 group genes, ETS translocation variant 4 (ETV4) is the most significantly up‐regulated in CIC‐deficient HCC cells, consequently promoting HCC progression. Furthermore, it induces expression of matrix metalloproteinase 1 ( MMP1 ), the MMP gene highly relevant to HCC progression, in HCC cells; and knockdown of MMP1 completely blocks the CIC deficiency–induced HCC cell proliferation and invasion. Conclusion: Our study demonstrates that the CIC–ETV4–MMP1 axis is a regulatory module controlling HCC progression. (H epatology 2018;67:2287‐2301).
Hybrid PET-MRI of the breast: A promising tool for the characterization of breast tumors.
Authors: Katja Pinker-Domenig, Hubert Bickel, Wolfgang Bogner, Heinrich Magometschnigg, Stephan Gruber, Peter Christian Dubsky, Ursula Pluschnig, Margaretha Rudas, Zsuzsanna Bago-Horvath, Thomas Helbich
Journal: Journal of Clinical Oncology (2012)

10570 Background: To evaluate if PET-MRI of breast tumors improves staging of breast cancer and obviates unnecessary breast biopsies. Methods: 106 patients with breast tumors detected by mammography or ultrasound and classified as BIRADS 3-5 were included in this IRB approved prospective study. All patients were examined with dedicated 18 FDG-PET-CT and 3T multiparametric MRI of the breast. Examinations were scheduled no longer than 7 days apart. MRI protocol included: a diffusion-weighted sequence (DWI), a T2-w sequence and a contrast-enhanced combined high temporal and spatial resolution 3D-T1-w sequence before and after application of a standard dose Gd-DOTA. For PET-CT patients fasted at least 6 h before injection of approx. 300 MBq 18 F-FDG based on the patients weight. Scanning was started 45 min after injection. Blood glucose levels were &lt;150 mg/dl. A prone PET dataset over the breasts was acquired using a positioning device allowing the same patient geometry as the breast MRI coil. CT data was used for attenuation correction. Co-registration of imaging data and image fusion were performed. PET-MRI was assessed for lesion morphology and EH-kinetics according to BI-RADS and restricted diffusivity with an ADC threshold 1.25 x10-3mm2/s set as the cut-off for malignancy. Lesions were assed for 18 F-FDG–avidity and classified as positive when 18 F-FDG-uptake was greater than blood-pool activity. Additionally, nodal status was recorded for each technique and patient. Histopathology was used as the standard of reference. Results: PET-MRI achieved an excellent sensitivity of 100%. Specificity was increased from 68% to 80% as compared to routinely used MRI. Diagnostic accuracy of PET-MRI for diagnosis of breast cancer was 95%. PET-MRI would have obviated unnecessary breast biopsies in 80% of benign breast lesions without missing any cancers. Additionally, PET-MRI increased sensitivity in the detection of lymphnode metastases from 70% to 87% compared to MRI alone. Conclusions: With PET-MRI unnecessary breast biopsies can be obviated without missing any cancers. PET-MRI increases overall diagnostic accuracy in the diagnosis of breast cancer and lymphnode metastases for an accurate staging.