tbuckley/cabot-search huggingface dataset:
Left Ventricular Ejection Fraction Cut Point of 50% for Heart Failure With Preserved Ejection Fraction—Reply
Authors: Marc A. Simon, Mehdi Nouraie, Mark T. Gladwin
Journal: JAMA Cardiology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Computed Tomographic Coronary Angiography Identification of Plaque Inflammation
Authors: Rory Hachamovitch, Venu Menon
Journal: JAMA Cardiology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Monocyte Immunophenotyping Reflects Aberrant Activation Patterns In Interstitial Lung Disease Patients
Authors: F. R. Greiffo, I. E. Fernandez, M. Frankenberger, A. Ortega-Gomez, J. Behr, O. Soehnlein, O. Eickelberg
Journal: American Journal of Respiratory and Critical Care Medicine (2017)
Association Between Mediterranean Anti-inflammatory Dietary Profile and Severity of Psoriasis
Authors: Céline Phan, Mathilde Touvier, Emmanuelle Kesse-Guyot, Moufidath Adjibade, Serge Hercberg, Pierre Wolkenstein, Olivier Chosidow, Khaled Ezzedine, Emilie Sbidian
Journal: JAMA Dermatology (2018)

<h3>Importance</h3> Psoriasis is a chronic inflammatory disease. The Mediterranean diet has been shown to reduce chronic inflammation and has a positive effect on the risk of metabolic syndrome and cardiovascular events. Thus, we hypothesized a positive effect on the onset and/or severity of psoriasis. <h3>Objective</h3> To assess the association between a score that reflects the adhesion to a Mediterranean diet (MEDI-LITE) and the onset and/or severity of psoriasis. <h3>Design, Setting, and Participants</h3> The NutriNet-Santé program is an ongoing, observational, web-based questionnaire cohort study launched in France in May 2009. The present study was performed within the framework of the NutriNet-Santé program, with data collected and analyzed between April 2017 and June 2017. Patients with psoriasis were identified via a validated online self-completed questionnaire and then categorized by disease severity: severe psoriasis, nonsevere psoriasis, and psoriasis-free. Data on dietary intake (including alcohol) were gathered during the first 2 years of participation in the cohort to calculate the MEDI-LITE score (ranging from 0 for no adherence to 18 for maximum adherence). Potentially confounding variables (eg, age, sex, physical activity, body mass index, tobacco use, and a history of cardiovascular disease) were also recorded. Analyses used adjusted multinomial logistic regression to estimate the risk of having severe psoriasis or nonsevere psoriasis compared with being psoriasis-free. <h3>Results</h3> Of the 158 361 total NutriNet-Santé participants, 35 735 (23%) replied to the psoriasis questionnaire. The mean (SD) age of the respondents was 47.5 (14.0) years; 27 220 (76%) of the respondents were women. Of these 35 735 respondents, 3557 (10%) individuals reported having psoriasis. The condition was severe in 878 cases (24.7%), and 299 (8.4%) incident cases were recorded (those arising more than 2 years after participant inclusion in the cohort). After adjustment for confounding factors, a significant inverse relationship was found between the MEDI-LITE score and having severe psoriasis: odds ratio (OR), 0.71; 95% CI, 0.55-0.92 for the MEDI-LITE score's second tertile (score of 8 to 9); and OR, 0.78; 95% CI, 0.59-1.01 for the third tertile (score of 10 to 18). <h3>Conclusions and Relevance</h3> Patients with severe psoriasis displayed low levels of adherence to the Mediterranean diet; this finding supports the hypothesis that the Mediterranean diet may slow the progression of psoriasis. If these findings are confirmed, adherence to a Mediterranean diet should be integrated into the routine management of moderate to severe psoriasis.
IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria
Authors: Akira Nakajima, Alexis Vogelzang, Mikako Maruya, Michio Miyajima, Megumi Murata, Aoi Son, Tomomi Kuwahara, Tatsuaki Tsuruyama, Satoshi Yamada, Minoru Matsuura, Hiroshi Nakase, Daniel A. Peterson, Sidonia Fagarasan, Keiichiro Suzuki
Journal: The Journal of Experimental Medicine (2018)

Immunoglobulin A (IgA) promotes health by regulating the composition and function of gut microbiota, but the molecular requirements for such homeostatic IgA function remain unknown. We found that a heavily glycosylated monoclonal IgA recognizing ovalbumin coats Bacteroides thetaiotaomicron (B. theta), a prominent gut symbiont of the phylum Bacteroidetes. In vivo, IgA alters the expression of polysaccharide utilization loci (PUL), including a functionally uncharacterized molecular family provisionally named Mucus-Associated Functional Factor (MAFF). In both mice and humans, MAFF is detected predominantly in mucus-resident bacteria, and its expression requires the presence of complex microbiota. Expression of the MAFF system facilitates symbiosis with other members of the phylum Firmicutes and promotes protection from a chemically induced model of colitis. Our data reveal a novel mechanism by which IgA promotes symbiosis and colonic homeostasis.
Sick sinus syndrome associated with anti-programmed cell death-1
Authors: Chien-Yi Hsu, Yu-Wen Su, San-Chi Chen
Journal: Journal for ImmunoTherapy of Cancer (2018)

<h3>Background</h3> Use of anti-programmed cell death-1 (anti-PD-1) has been successful in treating many types of cancers. Despite its promising efficacy, immune-related adverse events are still a major concern. Immune-related cardiotoxicity, which is rare but fatal, has recently become a focus of attention. Cardiotoxicities including myocarditis, cardiomyopathy, cardiac fibrosis, heart block and cardiac arrest have been reported. Of these toxicities, myocarditis is often accompanied by dysrhythmia. The presentation of sick sinus syndrome as an immune-related adverse event has not yet been reported. Here, we reported the first case of sick sinus syndrome, a rare toxicity induced by anti-PD-1. <h3>Case presentation</h3> A 42-year-old male patient who had metastatic hepatocellular carcinoma failed treatment with sorafenib. Pembrolizumab at a fixed dose of 100&nbsp;mg every three weeks was given. His heart rate gradually slowed down and he presented sick sinus syndrome with a lowest heart rate of 38&nbsp;bpm after six cycles of pembrolizumab. He denied chest tightness, cold sweating, palpitation and dyspnea. Lab data including cardiac enzyme, electrolytes and thyroid function were all within a normal range. Simultaneously, he complained of fatigue, dizziness and anorexia with hypotension. Lab data revealed low cortisol and ACTH levels. Anti-PD-1 induced adrenal insufficiency was suspected. Low-dose cortisone (12.5&nbsp;mg) was prescribed, and the patient's symptoms, hypotension and sick sinus syndrome showed rapid improvement. Cortisone was gradually titrated and discontinued three weeks later. His sick sinus syndrome did not relapse and the cortisol and ACTH level returned to normal. <h3>Conclusions</h3> Sick sinus syndrome caused by anti-PD-1 treatment is a rare adverse event. With the development of sick sinus syndrome, myocarditis should be the first differential diagnosis because of its lethality. From this case, we learned that sick sinus syndrome may be a presentation of immune- or adrenal insufficiency-mediated sinus node dysfunction, both could be reversed with a glucocorticoid supplement.
Severity of allergic asthma is associated to multiple dog and/or cat allergen component sensitization
Authors: S. Suzuki, L. Ekerljung, Magnus Borres, S. Sjölander, R. Mincheva, E. Ronmark, J. Lotvall
Journal: Allergy (2016)

Severity of allergic asthma is associated to multiple dog and/or cat allergen component sensitization
Therapeutic landscape in mutational triple negative breast cancer
Authors: Yaqin Shi, Juan Jin, Wenfei Ji, Xiaoxiang Guan
Journal: Molecular Cancer (2018)

Triple negative breast cancer (TNBC) is a heterogeneous disease with aggressive behavior and poor prognosis. Genomic sequencing has detected a distinctive mutational portrait of both the germline and somatic alterations in TNBC, which is staggeringly different from other breast cancer subtypes. The clinical utility of sequencing germline BRCA1/2 genes has been well established in TNBC. However, for other predisposition genes, studies concerning the risk and penetrance to TNBC are relatively scarce. Very few recurrent mutations, including TP53 and PI3KCA mutations, together with a long tail of individually rare mutations occur in TNBC. These combined effects of genomic alterations drive TNBC progression. Given the complexity and heterogeneity of TNBC, clinical interpretation of the genomic alterations in TNBC may pave a new way for the treatment of TNBC. In this review, we summarized the germline and somatic mutation profiles of TNBC and discussed the current and upcoming therapeutic strategies targeting the mutant proteins or pathways to enable tailored-therapeutics.
Abstract 15770: Sex Differences in Growth Rates of Thoracic Aortic Aneurysms
Authors: Katie Cheung, Munir Boodhwani, Kwan-Leung Chan, Luc Beauchesne, Alexander Dick, Thais Coutinho
Journal: Circulation (2015)

Introduction: Thoracic aortic aneurysm (TAA) is a deadly disease of increasing prevalence. Although more prevalent in men, TAA-related mortality is higher in women. In addition, women develop acute aortic syndromes at smaller aneurysm diameters, independently of body size. However, the basis for worse TAA outcomes in women is unknown. Since faster TAA growth is an established risk factor for acute aortic syndromes, we sought to determine the role of sex on TAA growth. Hypothesis: We hypothesized that TAA growth rates differ based on sex. Methods: Fifty three consecutive unoperated subjects with TAA who had serial aneurysm measurements by CT, MRI or echocardiography were prospectively recruited. Aneurysm size was measured systematically by an imaging cardiologist (TC); growth rate was calculated as mm/year. In multivariable linear regression, the association of female sex with aneurysm growth rate was assessed after adjustment for age, and then additional adjustment for body surface area, baseline aneurysm size, beta-blocker use and history of hypertension, diabetes, dyslipidemia and smoking. Results: Thirty seven (70%) subjects were men; mean±SD age was 63.7±11.9 years (62.2±12.3 in men, 66.9±10.6 in women, P =0.17). Thirty (57%) subjects had degenerative TAAs, the remainder had heritable TAAs. Fifteen had maximal dilation at the aortic root, and 38 at the ascending aorta. Baseline aneurysm size and follow-up time were 45.4±4.5 mm and 3.01±2.9 years, respectively, and not different between men and women ( P &gt;0.05 for both). Aneurysm growth rate was 1.22±1.09 mm/year in women and 0.68±0.68 mm/year in men. Female sex was significantly associated with greater aneurysm growth rate after adjustment for age (β±SE: 0.25±0.13, P =0.05) and additional adjustment for confounders (β±SE: 0.30±0.14, P =0.03). Notably, baseline aneurysm size was not associated with TAA growth (β±SE: -0.01±0.0.03, P =0.72). Conclusions: In subjects with TAA from different etiologies, reflecting clinical practice, aneurysm growth rates are greater in women than men. Our findings may potentially explain sex differences in TAA outcomes, providing a foundation for future investigations aimed at assessing causes for faster aneurysm growth and acute aortic syndromes in women.
<scp>l</scp> -Glutamine and the Dawn of Combination Therapy for Sickle Cell Disease
Authors: Caterina P. Minniti
Journal: New England Journal of Medicine (2018)

In 2017, the U.S. Food and Drug Administration approved l-glutamine (USAN, glutamine) for the prevention of acute vaso-occlusive pain events in persons with sickle cell disease who are older than 5 years of age — only the first drug to be approved for this indication in the 20 years since the approval of hydroxyurea. The much awaited data that supported this landmark approval are available for review in the article by Niihara et al. in this issue of the Journal.1 In a phase 3, randomized, double-blind, placebo-controlled trial involving 230 patients (5 to 58 years old) with homozygous hemoglobin S . . .
Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea (SOX). A Randomized Continuous Positive Airway Pressure Withdrawal Trial
Authors: Chris D. Turnbull, Dushendree Sen, Malcolm Kohler, Nayia Petousi, John R. Stradling
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Rationale: Obstructive sleep apnea (OSA) is associated with systemic hypertension. Either overnight intermittent hypoxia, or the recurrent arousals that occur in OSA, could cause the daytime increases in blood pressure (BP).Objectives: To establish the role of intermittent hypoxia in the increased morning BP in patients with OSA.Methods: Randomized, double-blinded, crossover trial assessing the effects of overnight supplemental oxygen versus air (sham) on morning BP, after continuous positive airway pressure (CPAP) withdrawal in patients with moderate to severe OSA. The primary outcome was the change in home morning BP after CPAP withdrawal for 14 nights, oxygen versus air. Secondary outcomes included oxygen desaturation index (ODI), apnea–hypopnea index (AHI), subjective sleepiness (Epworth Sleepiness Scale score), and objective sleepiness (Oxford Sleep Resistance Test).Measurements and Main Results: Supplemental oxygen virtually abolished the BP rise after CPAP withdrawal and, compared with air, significantly reduced the rise in mean systolic BP (−6.6 mm Hg; 95% confidence interval [CI], −11.3 to −1.9; P = 0.008), mean diastolic BP (−4.6 mm Hg; 95% CI, −7.8 to −1.5; P = 0.006), and median ODI (−23.8/h; interquartile range, −31.0 to −16.3; P < 0.001) after CPAP withdrawal. There was no significant difference, oxygen versus air, in AHI, subjective sleepiness, or objective sleepiness.Conclusions: Supplemental oxygen virtually abolished the rise in morning BP during CPAP withdrawal. Supplemental oxygen substantially reduced intermittent hypoxia, but had a minimal effect on markers of arousal (including AHI), subjective sleepiness, or objective sleepiness. Therefore intermittent hypoxia, and not recurrent arousals, appears to be the dominant cause of daytime increases in BP in OSA.
Ten-Year Survival After Peptide Receptor Radionuclide Therapy of a Metastatic Well-differentiated G3 Pancreatic Neuroendocrine Neoplasm
Authors: Jingjing Zhang, Harshad R. Kulkarni, Aviral Singh, Richard P. Baum
Journal: Clinical Nuclear Medicine (2018)

Substantial molecular and clinical heterogeneity of high-grade neuroendocrine neoplasms (NENs) G3, all of which were previously referred to as neuroendocrine carcinomas, has been observed. Although data are still limited, somatostatin receptor expression in well-differentiated G3 NENs of the pancreas (according to the new WHO 2017 classification) may enable peptide receptor radionuclide therapy for these patients. We report our treatment experience of a G3 NEN patient with discordant Ki-67 proliferation indices (between primary tumor and the metastases), who had a long survival over a span of 10 years with excellent quality of life and no adverse effects after repeated cycles of PRRT.
Mouse Homolog of the Human <i>TP53</i> R337H Mutation Reveals Its Role in Tumorigenesis
Authors: Ji-Hoon Park, Jie Li, Matthew F. Starost, Chengyu Liu, Jie Zhuang, Jichun Chen, Maria I. Achatz, Ju-Gyeong Kang, Ping-yuan Wang, Sharon A. Savage, Paul M. Hwang
Journal: Cancer Research (2018)

Inheritance of germline mutations in the tumor suppressor gene
Don't characterize replications as successes or failures
Authors: Andrew Gelman
Journal: Behavioral and Brain Sciences (2018)

Abstract No replication is truly direct, and I recommend moving away from the classification of replications as “direct” or “conceptual” to a framework in which we accept that treatment effects vary across conditions. Relatedly, we should stop labeling replications as successes or failures and instead use continuous measures to compare different studies, again using meta-analysis of raw data where possible.
Comparative Effectiveness of CT-Derived Atherosclerotic Plaque Metrics for Predicting Myocardial Ischemia
Authors: Hooman Bakhshi, Zahra Meyghani, Satoru Kishi, Tiago A. Magalhães, Andrea Vavere, Pieter H. Kitslaar, Richard T. George, Hiroyuki Niinuma, Johan H.C. Reiber, Aisha Betoko, Matthew Matheson, Carlos E. Rochitte, Marcelo F. Di Carli, Christopher Cox, João A.C. Lima, Armin Arbab-Zadeh
Journal: JACC. Cardiovascular imaging (2018)
Systemic-to-pulmonary arterial connections simulating pulmonary emboli in a patient with Tetralogy of Fallot
Authors: Chanel M Wood, Christopher J McLeod, Pragnesh P Parikh, Carlos A Rojas
Journal: Thorax (2018)

A middle-aged patient with a history of Tetralogy of Fallot repair (status post modified Blalock-Taussig shunt, right ventricular outlet tract reconstruction and ventricular septal defect repair, with more recent pulmonary artery patch annuloplasty with dilation and stenting, pulmonary valve replacement and aortic valve and root replacement) and symptomatic atrial tachycardia on coumadin therapy presented to an outside institution with dyspnoea and recurrent atrial fibrillation. The patient underwent CT pulmonary angiogram (CTPA), which demonstrated multiple unopacified areas in the bilateral segmental pulmonary artery branches; however, international normalised ratio was supratherapeutic at 4.1. The patient was transferred to our facility for suspected pulmonary emboli (PE). On assessment, the patient was noted to be in atrial fibrillation without evidence of hypoxia or respiratory compromise. In the context of adequate anticoagulation and a lack of clinical …
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy
Authors: Tong Shen, Ling-Dong Cai, Yu-Hong Liu, Shi Li, Wen-Juan Gan, Xiu-Ming Li, Jing-Ru Wang, Peng-Da Guo, Qun Zhou, Xing-Xing Lu, Li-Na Sun, Jian-Ming Li
Journal: Journal of Hematology & Oncology (2018)

Ubiquitination is a basic post-translational modification for cellular homeostasis, and members of the conjugating enzyme (E2) family are the key components of the ubiquitin-proteasome system. However, the role of E2 family in colorectal cancer (CRC) is largely unknown. Our study aimed to investigate the role of Ube2v1, one of the ubiquitin-conjugating E2 enzyme variant proteins (Ube2v) but without the conserved cysteine residue required for the catalytic activity of E2s, in CRC.Immunohistochemistry and real-time RT-PCR were used to study the expressions of Ube2v1 at protein and mRNA levels in CRC, respectively. Western blotting and immunofluorescence, transmission electron microscopy, and in vivo rescue experiments were used to study the functional effects of Ube2v1 on autophagy and EMT program. Quantitative mass spectrometry, immunoprecipitation, ubiquitination assay, western blotting, and real-time RT-PCR were used to analyze the effects of Ube2v1 on histone H4 lysine 16 acetylation, interaction with Sirt1, ubiquitination of Sirt1, and autophagy-related gene expression.Ube2v1 was elevated in CRC samples, and its increased expression was correlated with poorer survival of CRC patients. Ube2v1 promoted migration and invasion of CRC cells in vitro and tumor growth and metastasis of CRC cells in vivo. Interestingly, Ube2v1suppressed autophagy program and promoted epithelial mesenchymal transition (EMT) and metastasis of CRC cells in an autophagy-dependent pattern in vitro and in vivo. Moreover, both rapamycin and trehalose attenuated the enhanced Ube2v1-mediated lung metastasis by inducing the autophagy pathway in an orthotropic mouse xenograft model of lung metastasis. Mechanistically, Ube2v1 promoted Ubc13-mediated ubiquitination and degradation of Sirt1 and inhibited histone H4 lysine 16 acetylation, and finally epigenetically suppressed autophagy gene expression in CRC.Our study functionally links Ube2v1, an E2 member in the ubiquitin-proteasome system, to autophagy program, thereby shedding light on developing Ube2v1 targeted therapy for CRC patients.
Stereotactic Body Radiation Therapy for Central Early-Stage NSCLC: Results of a Prospective Phase I/II Trial
Authors: Michael C. Roach, Cliff G. Robinson, Todd A. DeWees, Jehan Ganachaud, Daniel Przybysz, Robert Drzymala, Sana Rehman, Rojano Kashani, Jeffrey D. Bradley
Journal: Journal of Thoracic Oncology (2018)
The Vectorcardiogram and Electrocardiogram in Persistent Common Atrioventricular Canal
Authors: Jonasberegovich, Selvynbleifer, Ephraimdonoso, Arthurgrishman
Journal: Circulation (1960)

The electrocardiogram and vectorcardiogram are of great aid in differentiating atrial septal defect of the secundum type from the ostium-primum type. In the latter condition there is left axis deviation in the scalar electrocardiogram and superior orientation of the QRS vector in the sagittal and frontal planes. There are relatively few congenital lesions that lead to the same degree of axis deviation and superior orientation of the QRS vector.