tbuckley/cabot-search huggingface dataset:
Establishing the Effectiveness of Procedural Interventions
Authors: Christopher J. D. Wallis, Allan S. Detsky, Eddy Fan
Journal: JAMA (2018)

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Initial Results from a Phase 1 Clinical Study of bb21217, a Next-Generation Anti Bcma CAR T Therapy
Authors: Nina Shah, Melissa Alsina, David S Siegel, Sundar Jagannath, Deepu Madduri, Jonathan L Kaufman, Ashley Turka, Lyh Ping Lam, Monica Massaro, Kristen Hege, Fabio Petrocca, Jesus G. Berdeja, Noopur Raje
Journal: Blood (2018)
Abstract 16198: Burnout and Career Satisfaction Among Cardiologists
Authors: Laxmi S Mehta, Sandra J Lewis, Claire S Duvernoy, Marian C Limacher, Athena Poppas, Mary Norine Walsh, Anne K Rzeszut, Mark Linzer, Robert A Harrington, Philip F Binkley, Rose S Cohen, Dipti Itchhaporia, Smadar Kort, Pamela S Douglas
Journal: Circulation (2017)

Introduction: Physician burnout adversely impacts patient care, but there are few data regarding prevalence or impact in cardiology. Methods: The American College of Cardiology’s (ACC) 2015 Profess...
Treating Victims of Child Sexual Abuse
Authors: Rochelle F. Hanson, Elizabeth Wallis
Journal: American Journal of Psychiatry (2018)

is a 9-year old girl, currently in third grade.She lives with her mother ("Ms.B") and her 14-year-old brother.At a recent visit to the pediatrician for a wellchild appointment, Anna refused to remove her clothes and became extremely agitated when the physician started to examine her.She started crying and disclosed that her stepfather had been "hurting" her.On further inquiry, she said that he had been forcing her to engage in "sex stuff."Ms. B was visibly shaken and distressed by the disclosure, stating that she had no idea this had happened.She did acknowledge that she and her husband had been experiencing marital problems, which resulted in his moving out of the home temporarily about 6 months ago, but she was still seeing him, and he was still at the house frequently.Ms. B did not understand how this could have happened since she rarely left her children alone with her husband.Furthermore, she said that she and Anna have a very close relationship and that Anna would have shared this if it had occurred.Since Anna was extremely upset after her disclosure and Ms. B was having difficulty believing the allegations, the pediatrician recommended a referral to the local Child Advocacy Center (CAC) for a medical examination and forensic interview.CACs provide a safe, child-focused environment and include a multidisciplinary team of professionals, comprising medical, mental health, law enforcement, prosecution, child protective services, victim advocacy, and school personnel, who work together to coordinate services for children.In addition to providing medical evaluations and forensic interviews after abuse disclosures, CACs offer therapy and medical examinations, courtroom preparation, victim advocacy, and ongoing case management.While Ms. B was still in the office, the pediatrician contacted the CAC to schedule the evaluation and allow Ms. B to speak directly with the CAC to provide any required information.The pediatrician then explained to Ms. B that a report would have to be made immediately to the local child protective services (CPS) office, as physicians are mandated reporters in cases of suspected child abuse.
Abstract 11935: A Successful Trial Multifaceted Randomized Trial of Home Blood Pressure Telemonitoring Plus Pharmacist Management: What Makes It Work and Who Benefits the Most?
Authors: Stephen Asche, Ann Bergdall, Steve Dehmer, Beverly Green, Michael Maciosek, Rachel Nyboer, Patrick O’Connor, Pamela Pawloski, JoAnn Sperl-Hillen, Nicole Trower, Ann Tucker, Karen Margolis
Journal: Circulation (2014)

Objectives: The Hyperlink trial tested a 12-month multi-component intervention (INT) in patients with uncontrolled hypertension, which resulted in improved blood pressure (BP) control compared to u...
Reappraising old friends: oxygen and primary care
Authors: Helen Macdonald
Journal: BMJ (2018)

We should stop treating oxygen as an old friend, say Daniel Horner and Ronan O’Driscoll in an editorial this week (doi:10.1136/bmj.k4436). Supplementary oxygen for medical inpatients has been widely used since the early 20th century, but evidence of its harms for some patients is mounting. A recent systematic review and meta-analysis of randomised controlled trials found that acutely ill medical inpatients randomised to liberal oxygen therapy were more likely to die than those given restricted therapy (risk ratio 1.21 (95% confidence interval 1.03 to 1.43)).1

But evidence from systematic reviews can be hard to …
Performance measures for endoscopy services: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative
Authors: Roland Valori, George Cortas, Thomas de Lange, Omer Balfaqih, Marjon de Pater, Pierre Eisendrath, Premysl Falt, Irfan Koruk, Akiko Ono, Nadan Rustemović, Erik Schoon, Andrew Veitch, Carlo Senore, Cristina Bellisario, Silvia Minozzi, Cathy Bennett, Michael Bretthauer, Mario Dinis-Ribeiro, Dirk Domagk, Cesare Hassan, Michal Kaminski, Colin Rees, Cristiano Spada, Raf Bisschops, Mathew Rutter
Journal: Endoscopy (2018)

The European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology present a list of key performance measures for endoscopy services. We recommend that these performance measures be adopted by all endoscopy services across Europe. The measures include those related to the leadership, organization, and delivery of the service, as well as those associated with the patient journey. Each measure includes a recommendation for a minimum and target standard for endoscopy services to achieve. We recommend that all stakeholders in endoscopy take note of these ESGE endoscopy services performance measures to accelerate their adoption and implementation. Stakeholders include patients and their advocacy groups; service leaders; staff, including endoscopists; professional societies; payers; and regulators.
Photodynamic therapy at ultra-low NIR laser power and X-Ray imaging using Cu<sub>3</sub>BiS<sub>3</sub> nanocrystals
Authors: Srivani Veeranarayanan, M. Sheikh Mohamed, Aby Cheruvathoor Poulose, Masuko Rinya, Yasushi Sakamoto, Toru Maekawa, D. Sakthi Kumar
Journal: Theranostics (2018)

Materials with efficient potential in imaging as well as therapy are gaining particular attention in current medical research. Photodynamic therapy (PDT) has been recently recognized as a promising treatment option for solid tumors. Still, most of the nanomaterial-based PDT modules either employ an additional photosensitizer or require high power laser sources. Also, they suffer from a lack of responsiveness in the near-infrared (NIR) region. Nanomaterials that could realize PDT independently (without any photosensitizer), at safe laser dose and in the deep tissue penetrative NIR region would definitely be better solid tumor treatment options. Methods: Herein, Cu- and Bi-based bimetal chalcogenide (Cu3BiS3), with absorption in the NIR region was developed. High-performance PDT of cancer and high-contrast x-ray imaging of tumor were performed in vivo. Biocompatibility of the NCs was also assessed in vivo. Results: The highlight of the results was the realization of ultra-low dose NIR laser-mediated PDT, which has not been achieved before, leading to complete tumor regression. This could be a breakthrough in providing a pain- and scar-less treatment option, especially for solid tumors and malignant/benign subcutaneous masses. Though the NCs are active in the photo-thermal therapy (PTT) regime as well, focus is given to the exciting aspect of extremely low power-induced PDT observed here. Conclusion: Their extended in vivo biodistribution with commendable hemo- and histo-compatibilities, along with imaging and multi-therapeutic capabilities, project these Cu3BiS3 NCs as promising, prospective theranostic candidates.
Preferential survival of mice and cells expressing human herpesvirus-8 K1
Authors: Shu Wang, Hoyoung Maeng, Suizhao Wang, Victor Yazbeck, Lei Jin, Anita Sabichi, Felipe Samaniego
Journal: Cancer Research (2007)

1930   HHV-8 is associated with the development of primary effusion lymphoma (PEL) and Kaposi’s sarcoma. Expression of the HHV-8  K1  gene driven by a ubiquitous promoter activates nuclear  factor-κB and induces lymph node hyperplasia and lymphomas in  transgenic mice. K1 inhibits Fas-mediated apoptosis in several lymphoma cell lines.  We report here that, compared with nontransgenic littermates, K1 transgenic mice developed enlarged spleens and lymph nodes and had increased rates of tumor development by the age of 15 months. Histological examination of the enlarged spleens demonstrated enlarged germinal centers or destruction of normal spleen structures and areas with clonal expansion of lymphocytes. Because K1 blocks Fas-mediated apoptosis in human cells, we treated splenocytes from K1 transgenic mice and their nontransgenic littermates with agonist anti-Fas antibody (Jo2) for 24 hours. Next, we examined cell death by DAPI staining followed by microscopic morphological change. K1-positive splenocytes showed significantly lower percentages of cell death compared with K1-negative splenocytes (23 ± 0.6% vs. 50 ± 0.5%, P in vivo  transfection approach to introduce Flag- or cMyc-tagged K1 into mice liver. Different strains of HHV-8 are identified by different K1 amino acid sequences. We transfected C57B6 mice with plasmids containing  K1  from different strains of HHV-8. The expression of K1 in mouse liver was confirmed by Western blot and immunohistochemistry. Sixteen hours after transfection, mice were challenged with a lethal dose of anti-Fas antibody. Four hours after challenged with anti-Fas antibody, mice were sacrificed and liver tissues were formalin fixed and paraffin embedded. The immunohistochemical staining showed lower percentages of cleaved caspase 3-positive cells in K1-transfected liver tissue compared with vector transfected liver tissue (58 ± 15% vs. 87 ± 9%, P  lower mouse death rates after challenge with anti-Fas antibody (P  We now hypothesize that K1  contributes to cell survival, lymphoproliferation, and lymphoma and may have a role in HHV-8 related human cancers.
Image Gallery: Transient localized livedo racemosa following liver embolization procedure for metastatic neuroendocrine tumour
Authors: C. Ma, C.T. Vu, R.J. Knebel, A. Brassard, M.A. Fung, D. Tartar
Journal: British Journal of Dermatology (2018)

Funding sources: none. Conflicts of interest: none declared. Dear Editor, A 54‐year‐old woman with a metastatic neuroendocrine tumour was admitted for transarterial bland embolization of liver metastases through the internal mammary artery. (a) After the procedure, she experienced vomiting and flushing, consistent with neuroendocrine tumour necrosis in addition to blanchable broken retiform erythema (livedo racemosa) on the right upper abdomen and breast. (b) Biopsy revealed thrombosis of a single vessel. Livedo racemosa is characterized by a pink‐to‐violaceous broken net‐like pattern due to accumulation of deoxygenated blood, classically seen with coagulopathies and vasculitides.1,2 It is considered to be a more severe form of livedo reticularis and most commonly associated with Sneddon syndrome. Our patient had no history suggestive of a coagulopathy, and livedo racemosa was limited geographically and rapidly improved; thrombosis was therefore felt to be secondary to the embolization procedure and resolved without intervention. ...
Probing the Virtual Proteome to Identify Novel Disease Biomarkers
Authors: Jonathan D. Mosley, Mark D. Benson, J. Gustav Smith, Olle Melander, Debby Ngo, Christian M. Shaffer, Jane F. Ferguson, Matthew S. Herzig, Catherine A. McCarty, Christopher G. Chute, Gail P. Jarvik, Adam S. Gordon, Melody R. Palmer, David R. Crosslin, Eric B. Larson, David S. Carrell, Iftikhar J. Kullo, Jennifer A. Pacheco, Peggy L. Peissig, Murray H. Brilliant, Terrie E. Kitchner, James G. Linneman, Bahram Namjou, Marc S. Williams, Marylyn D. Ritchie, Kenneth M. Borthwick, Krzysztof Kiryluk, Frank D. Mentch, Patrick M. Sleiman, Elizabeth W. Karlson, Shefali S. Verma, Yineng Zhu, Ramachandran S. Vasan, Qiong Yang, Josh C. Denny, Dan M. Roden, Robert E. Gerszten, Thomas J. Wang
Journal: Circulation (2018)

Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying these technologies to massive biobanks is not currently feasible because of the practical barriers and costs of implementing such assays at scale. To overcome these challenges, we used a "virtual proteomic" approach, linking genetically predicted protein levels to clinical diagnoses in >40 000 individuals.We used genome-wide association data from the Framingham Heart Study (n=759) to construct genetic predictors for 1129 plasma protein levels. We validated the genetic predictors for 268 proteins and used them to compute predicted protein levels in 41 288 genotyped individuals in the Electronic Medical Records and Genomics (eMERGE) cohort. We tested associations for each predicted protein with 1128 clinical phenotypes. Lead associations were validated with directly measured protein levels and either low-density lipoprotein cholesterol or subclinical atherosclerosis in the MDCS (Malmö Diet and Cancer Study; n=651).In the virtual proteomic analysis in eMERGE, 55 proteins were associated with 89 distinct diagnoses at a false discovery rate q<0.1. Among these, 13 associations involved lipid (n=7) or atherosclerosis (n=6) phenotypes. We tested each association for validation in MDCS using directly measured protein levels. At Bonferroni-adjusted significance thresholds, levels of apolipoprotein E isoforms were associated with hyperlipidemia, and circulating C-type lectin domain family 1 member B and platelet-derived growth factor receptor-β predicted subclinical atherosclerosis. Odds ratios for carotid atherosclerosis were 1.31 (95% CI, 1.08-1.58; P=0.006) per 1-SD increment in C-type lectin domain family 1 member B and 0.79 (0.66-0.94; P=0.008) per 1-SD increment in platelet-derived growth factor receptor-β.We demonstrate a biomarker discovery paradigm to identify candidate biomarkers of cardiovascular and other diseases.
Abstract 17281: Acute ECG Changes During Authentic Obstructive Sleep Apnea and Hypopneas in Humans
Authors: Pavan Reddy, Edwin M Valladares, Apurva Akkad, Liza Garabet-Diramerian, Marek Orban, Philip Chang, Rahul N Doshi, Terese Hammond, Tomas Konecny
Journal: Circulation (2017)

Introduction: Obstructive sleep apnea/hypopnea (OSAH) is strongly associated with atrial and ventricular arrhythmias yet exact underlying mechanisms remain unclear. Hypothesis: Human authentic (non...
Reply to Michael Staehler, Dena Battle, Axel Bex, Hans Hammers, and Daniel George's Letter to the Editor re: Arnaud Méjean, Alain Ravaud, Simon Thezenas, et al. Sunitinib Alone or After Nephrectomy in Metastatic Renal-cell Carcinoma. Eur Urol 2018;74:842–3
Authors: Matteo Santoni, Rodolfo Montironi, Nicola Battelli, Francesco Massari
Journal: European Urology (2018)
Drug company charged over substandard parenteral nutrition used in babies
Authors: Clare Dyer
Journal: BMJ (2018)

A pharmaceutical company which supplies intravenous feed for babies has been charged with offences after a four year investigation by the Metropolitan Police and the Medicines and Healthcare Products Regulatory Agency (MHRA).

A total of 23 babies at nine hospitals in north west London developed a bacterial infection after receiving total parenteral nutrition supplied by ITH Pharma. Three died but only the death of Yousef Al-Kharboush, a twin who …
Abstract 17878: Hospital Admission Rates for Myocardial Infarction and Stroke in New York City Before and After the Ban on Trans Fatty Acids
Authors: Eric J Brandt, Rebecca Myerson, Marcelo Coca Perraillon, Tamar Polonsky
Journal: Circulation (2015)

Introduction: Numerous bans on the use of trans fatty acids (TF)s in eateries are in effect across the United States. No studies have examined cardiovascular event rates after the bans were enacted. Hypothesis: The July 1, 2007 ban on TFs in restaurants and food trucks in New York City (NYC) was associated with an accelerated decline in MI and stroke. Methods: We used the 2002-2013 New York Department of Health Statewide Planning and Research Cooperative System (SPARCS) data to calculate hospital admission rates for incident of MI and stroke in NYC residents (using county of residence). Diagnosis was established using primary discharge ICD-9-CM codes 410.00-410.99 for MI and 430.00-438.99 for stroke. Rates were calculated using Census 2000 and 2010 data and intercensal estimates. Incidence rates of MI and stroke declined between 2002 and 2007. To analyze whether there was additional decline from these prior trends after implementation of the NYC TF ban, we used negative binomial regression to model event trends and compare this to actual trends. We also used publicly available data from the 2004 NYC Health and Nutrition Examination Survey (NYC HANES) to investigate restaurant usage per week among NYC residents. This was reported as never, less than weekly (we estimated as 0.5 uses per week), or 1 to 25 uses per week. All analyses were stratified by decade of age. Results: After 2007, younger age groups (25-34 and 35-44) experienced an additional decline in stroke (see table), but not MI, that was greater than would have been expected based on temporal trends. Younger age groups also reported higher mean restaurant use in NYC HANES. Conclusions: Stroke rates in NYC among younger adults declined faster than would have been expected after the 2007 TF ban. Additionally, younger age groups were also those that had highest restaurant usage. Further study to compare event trends in NYC counties to other New York counties is warranted to investigate if this trend is related to other secular trends.
Intertumoral Heterogeneity of 18F-FDG and 68Ga-PSMA Uptake in Prostate Cancer Pulmonary Metastases
Authors: Paola M. Perez, Thomas A. Hope, Spencer C. Behr, Annemieke van Zante, Eric J. Small, Robert R. Flavell
Journal: Clinical Nuclear Medicine (2018)

We present a case of a 61-year-old man with history of prostate cancer and rising PSA levels referred for restaging. Ga-PSMA-11 PET/CT identified 2 lung nodules with low and moderate PSMA uptake. Subsequent F-FDG PET/CT showed high hypermetabolism in the nodule with low PSMA uptake, and low hypermetabolism in the nodule with moderate PSMA uptake. The isolated pulmonary findings and metabolic appearance is an atypical presentation of prostate cancer metastases and raised concern for a second primary malignancy. Fine-needle aspiration of the F-FDG active lung nodule confirmed metastatic prostatic adenocarcinoma that subsequently responded to androgen deprivation therapy and abiraterone acetate.
Phytophthora methylomes are modulated by 6mA methyltransferases and associated with adaptive genome regions
Authors: Han Chen, Haidong Shu, Liyuan Wang, Fan Zhang, Xi Li, Sylvans Ochieng Ochola, Fei Mao, Hongyu Ma, Wenwu Ye, Tingting Gu, Lubin Jiang, Yufeng Wu, Yuanchao Wang, Sophien Kamoun, Suomeng Dong
Journal: Genome biology (2018)

Filamentous plant pathogen genomes often display a bipartite architecture with gene-sparse, repeat-rich compartments serving as a cradle for adaptive evolution. The extent to which this two-speed genome architecture is associated with genome-wide DNA modifications is unknown. We show that the oomycetes Phytophthora infestans and Phytophthora sojae possess functional adenine N6-methylation (6mA) methyltransferases that modulate patterns of 6mA marks across the genome. In contrast, 5-methylcytosine could not be detected in these species. Methylated DNA IP sequencing (MeDIP-seq) of each species reveals 6mA is depleted around the transcription start sites (TSSs) and is associated with lowly expressed genes, particularly transposable elements. Genes occupying the gene-sparse regions have higher levels of 6mA in both genomes, possibly implicating the methylome in adaptive evolution. All six putative adenine methyltransferases from P. infestans and P. sojae, except PsDAMT2, display robust enzymatic activities. Surprisingly, single knockouts in P. sojae significantly reduce in vivo 6mA levels, indicating that the three enzymes are not fully redundant. MeDIP-seq of the psdamt3 mutant reveals uneven 6mA methylation reduction across genes, suggesting that PsDAMT3 may have a preference for gene body methylation after the TSS. Furthermore, transposable elements such as DNA elements are more active in the psdamt3 mutant. A large number of genes, particularly those from the adaptive genomic compartment, are differentially expressed. Our findings provide evidence that 6mA modification is potentially an epigenetic mark in Phytophthora genomes, and complex patterns of 6mA methylation may be associated with adaptive evolution in these important plant pathogens.