tbuckley/cabot-search huggingface dataset:
La mortalité en Espagne durant la vague de chaleur de l'été 2003
Authors: F Simon, G Lopez-Abente, E Ballester, F Martinez
Journal: Eurosurveillance (2005)

L’impact des temperatures elevees sur la mortalite a ete observe dans plusieurs pays d’Europe pendant l’ete 2003. L’etude suivante, portant sur l’Espagne, decrit la mortalite entre le 1er juin et le 31 aout et evalue l’effet de la canicule sur la mortalite. 
Le nombre de deces observes a ete obtenu par le biais des registres de deces des 50 capitales de provinces. Le nombre de ces deces a ete compare avec celui des deces attendus, estimes en appliquant un modele de regression de Poisson aux series de mortalite historiques et en l’ajustant pour la tendance a la hausse et pour la saison. Les informations meteorologiques ont ete fournies par l’Institut national de meteorologie.
Reduction of benzoquinone ansamycin Hsp90 inhibitors by NQO1 generates hydroquinone ansamycins which are more potent Hsp90 inhibitors
Authors: Wenchang Guo, Philip Reigan, David Siegel, Joseph Zirrolli, Daniel Gustafson, David Ross
Journal: Cancer Research (2006)

1338  The benzoquinone ansamycin Hsp90 inhibitor 17-allyamino-demethoxygeldanamycin (17AAG) can be reduced by NAD(P)H:Quinone oxidoreductase 1 (NQO1) to generate a more water soluble and more potent hydroquinone ansamycin Hsp90 inhibitor, 17AAGH2 (Guo et al., Cancer Res. 2005; 65, 10006-15). Here we extended this work to other benzoquinone ansamycin Hsp90 inhibitors including geldanamycin (GA), 17AG, 17DMAG and 17AEP-GA. HPLC analysis of the metabolism of these quinones by rhNQO1 revealed that all these benzoquinone ansamycin compounds could be reduced by NQO1 to form their corresponding hydroquinones. The hydroquinones, as expected, are more water soluble than their parent quinones as indicated by a shorter retention time on reverse phase HPLC. Hydroquinone formation was NQO1-dependent and could be blocked by ES936, a mechanism-based (suicide) inhibitor of NQO1. The formation of hydroquinone ansamycins following the reduction of their parent quinones by rhNQO1 was confirmed by LC-MS. We then used an isogenic pair of human breast cancer cell lines (MDA468 and MDA468/NQ16) to determine the role of NQO1 in benzoquinone ansamycin metabolism. MDA468 cells lack NQO1 activity due to a genetic polymorphism and MDA468/NQ16 cells are stably transfected MDA468 cells expressing high levels of NQO1. In growth inhibition studies (MTT) MDA468/NQ16 cells were 3-9 fold more sensitive to benzoquinone ansamycin Hsp90 inhibitors than the parent MDA468 cells following a 4hr drug exposure and this increased sensitivity could be abrogated by pretreatment with ES936. There was no difference in the sensitivity between these two cell lines to the non-quinone Hsp90 inhibitor radicicol under identical treatment conditions. The ability of the benzoquinone ansamycin Hsp90 inhibitors and their corresponding hydroquinones to inhibit purified yeast Hsp90 ATPase activity was examined. In these studies maximal inhibition was observed in the presence of NQO1 and NAD(P)H, and this increased inhibition could be abrogated by ES936. In conclusion, as seen previously with 17AAG, the reduction of benzoquinone ansamycin Hsp90 inhibitors including GA, 17AG, 17DMAG and 17AEP-GA by NQO1 to form their corresponding hydroquinone generates more water soluble and more potent Hsp90 inhibitors (supported by CA51210).
Oxytocin shapes the priorities and neural representations of attitudes and values
Authors: René Hurlemann, Nina Marsh, Johannes Schultz, Dirk Scheele
Journal: Behavioral and Brain Sciences (2017)

Abstract The phylogenetically ancient neuropeptide oxytocin has been linked to a plethora of social behaviors. Here, we argue that the action of oxytocin is not restricted to the downstream level of emotional responses, but substantially alters higher representations of attitudes and values by exerting a distant modulatory influence on cortical areas and their reciprocal interplay with subcortical regions and hormonal systems.
STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1α
Authors: Fanyang Kong, Xiangyu Kong, Yiqi Du, Ying Chen, Xuan Deng, Jianwei Zhu, Jiawei Du, Lei Li, Zhiliang Jia, Dacheng Xie, Zhaoshen Li, Keping Xie
Journal: Cancer Research (2017)

Abstract The serine/threonine kinase STK33 has been implicated in cancer cell proliferation. Here, we provide evidence of a critical role for STK33 in the pathogenesis and metastatic progression of pancreatic ductal adenocarcinoma (PDAC). STK33 expression in PDAC was regulated by the hypoxia-inducible transcription factor HIF1α. In human PDAC specimens, STK33 was overexpressed and associated with poor prognosis. Enforced STK33 expression promoted PDAC proliferation, migration, invasion, and tumor growth, whereas STK33 depletion exerted opposing effects. Mechanistic investigations showed that HIF1α regulated STK33 via direct binding to a hypoxia response element in its promoter. In showing that dysregulated HIF1α/STK33 signaling promotes PDAC growth and progression, our results suggest STK33 as a candidate therapeutic target to improve PDAC treatment. Cancer Res; 77(24); 6851–62. ©2017 AACR.
NDEx 2.0: A Clearinghouse for Research on Cancer Pathways
Authors: Dexter Pratt, Jing Chen, Rudolf Pillich, Vladimir Rynkov, Aaron Gary, Barry Demchak, Trey Ideker
Journal: Cancer Research (2017)

We present NDEx 2.0, the latest release of the Network Data Exchange (NDEx) online data commons (www.ndexbio.org) and the ways in which it can be used to (i) improve the quality and abundance of biological networks relevant to the cancer research community; (ii) provide a medium for collaboration involving networks; and (iii) facilitate the review and dissemination of networks. We describe innovations addressing the challenges of an online data commons: scalability, data integration, data standardization, control of content and format by authors, and decentralized mechanisms for review. The practical use of NDEx is presented in the context of a novel strategy to foster network-oriented communities of interest in cancer research by adapting methods from academic publishing and social media. Cancer Res; 77(21); e58-61. ©2017 AACR.
Casos de Ortopoxvirose símia humanos em Kasai, Zaire (1996-1997)
Authors: P. T. Mwanbal, K F Tshioko, A Moudi, V Mukinda, G. N. Mwema, D Messinger, L Okito, D Barakymfyte, P Malfait, R G Pebody, M Szczeniowski, K Esteves, D Heymann, Y Hutin, R J Williams, A. S. Khan, J J Esposito
Journal: Eurosurveillance (1997)

O ortopoxvirus simio, tambem chamado de virus da variola do macaco, circula de forma enzootica nas florestas tropicais da Africa central e ocidental; pode transmitir-se ao homem, causando um sindroma cujas manifestacoes clinicas sao analogas as da variola (erupcao de pustulas, febre, sintomas respiratorios com um desenlace fatal em certos casos). De Fevereiro a Agosto de 1996, foram declarados um total de 71 casos clinicos de ortopoxvirus simio, dos quais 6 mortais, em 13 aldeias da zona sanitaria de Katako-Kombe (populacao em 1996: 15 698 habitantes), sub-regiao de Sankuru, regiao de Kasai oriental (Zaire).
Duration of the efficacy of omalizumab after treatment discontinuation in ‘real life’ severe asthma
Authors: Maria del Carmen Vennera, Carlos Sabadell, Cesar Picado
Journal: Thorax (2017)

Efficacy of omalizumab in severe asthma is well documented; however, the optimal duration of the treatment remains unclear. In an open prospective study, we sought to assess the persistence of response in subjects withdrawing from omalizumab treatment. We evaluated 49 patients who voluntarily accepted to discontinue omalizumab treatment after 6 years of therapy. Asthma relapse was defined as any severe asthma exacerbation associated with loss of asthma control. Twelve patients relapsed in the first year of follow-up, and 7 within 13 and 48 months. These results suggest that the effects of 6 years of omalizumab may persist after discontinuation of therapy in 60% of patients for at least 4 years.
Cholera in Yemen — An Old Foe Rearing Its Ugly Head
Authors: Firdausi Qadri, Taufiqul Islam, John D. Clemens
Journal: New England Journal of Medicine (2017)

With Yemen experiencing one of the largest cholera outbreaks in recent history, greater funding for the cholera vaccine stockpile and more work on the development of both improved predictive tools and improved water and sanitation are important priorities.
ESB: il contesto regolatorio europeo
Authors: T Chalus, I Peutz
Journal: Eurosurveillance (2000)

La crisi provocata dalla Encefalopatia Spongiforme Bovina (ESB) ha indotto nella Comunita Europea un radicale ripensamento sul modo di affrontare tutte le questioni relative alla sicurezza degli alimenti. Tra il 28 luglio1989, quando sono cominciate le restrizioni del trasporto di bovini vivi provenienti dal Regno Unito, e il 29 giugno 2000, data della proibizione dell’uso dei tessuti che presentano un rischio di ESB, i cosiddetti materiali a rischio attribuito (Specified Risk Material - SRM) in tutta l’Unione Europea, tutte le Decisioni adottate si sono basate su clausole di salvaguardia come sono state definite nelle direttive veterinarie. A termine, e in accordo con il Trattato di Amsterdam, tutte queste Decisioni dovrebbero essere sostituite da una legislazione primaria, formulata dal Parlamento Europeo, dal Consiglio e dalla Commissione.
Whole brain radiation therapy (WBRT) with or without oral topotecan (TPT) in patients (pts) with non-small cell lung cancer (NSCLC) with brain metastases: Final analysis of an open-label phase III study.
Authors: Rodryg Ramlau, Jacek Jassem, Zsolt Papai-Szekely, Pierre Chabot, Philippe Legenne, Jeremey Levin, Jadwiga Sherlock, Stephen R. Lane, John J Brennan, Tracey Sessa, Paul Stephen Wissel, Philip Bonomi
Journal: Journal of Clinical Oncology (2013)

2031 Background: Brain metastases from NSCLC occur in ~ 20% of pts and if untreated are associated with a 1 to 2 month overall survival (OS). Pre-clinical studies show that TPT added to radiation results in a radiotherapy enhancement ratio of 1.4 to 1.6. This trial was designed to test the effect of TPT co-administered with WBRT on OS. Methods: Pts with NSCLC and at least one measurable brain lesion were eligible. 472 pts were randomized to WBRT (3 Gy/day x 10 days) or WBRT and TPT 1.1 mg/m 2 /day for 10 days. Stratification factors: number of brain metastases and recursive partitioning analysis (RPA) class. Two weeks following WBRT, systemic anti-cancer therapy could be restarted at the treating physician’s discretion. Results: 468 pts were in the modified ITT population; 235 pts (WBRT + TPT) and 233 pts (WBRT+ best supportive care [BSC]). Of the 235 pts administered WBRT + TPT, 91 also received TPT after WBRT. The treatment arms were balanced for gender, age and smoking history. Median daily TPT dose was 2.25 mg. The median OS in the TPT arm was not better than in the BSC alone arm; 4.0 months (95%CI 3.4,4.8) vs.3.6 months (95%CI 3.0, 4.0), respectively; HR 0.88 (0.73, 1.07), P=0.1862. In the ITT population analysis by stratification variables, RPA class (I vs. II/III) was significantly different (HR 0.59) whereas baseline brain lesions (1 vs &gt;1) were not (HR 0.97). Complete response and overall response rates in the WBRT+ TPT were 10% and 27%, and with BSC 5% and 26%, respectively. There were no differences in time to response or neurologic signs and symptoms. All adverse events (AEs) were more frequent in the TPT arm (87% vs. 64%) as were AEs related to study treatment (57% vs. 21%), serious AEs (41% vs. 18%) and fatal AEs (5% vs. 0%). The AEs more frequently seen in the TPT arm were typical for TPT (hematologic toxicity, febrile neutropenia and diarrhea). Conclusions: The study did not achieve its primary objective. There was no difference in OS achieved by the addition of TPT to WBRT. AEs were more common in the TPT arm. Clinical trial information: NCT00390806.
The Use of Language in Diabetes Care and Education
Authors: Jane K. Dickinson, Susan J. Guzman, Melinda D. Maryniuk, Catherine A. O’Brian, Jane K. Kadohiro, Richard A. Jackson, Nancy D’Hondt, Brenda Montgomery, Kelly L. Close, Martha M. Funnell
Journal: Diabetes Care (2017)

Language is powerful and can have a strong impact on perceptions as well as behavior. A task force, consisting of representatives from the American Association of Diabetes Educators (AADE) and the American Diabetes Association (ADA), convened to discuss language in diabetes care and education. This document represents the expert opinion of the task force. The literature supports the need for a language movement in diabetes care and education. There are effective ways of communicating about diabetes. This article provides recommendations for language used by health care professionals and others when discussing diabetes through spoken or written words-whether directed to people with diabetes, colleagues, or the general public, as well as research questions related to language and diabetes.
La carga socioeconómica de las infecciones hospitalarias
Authors: R Plowman
Journal: Eurosurveillance (2000)

Segun los resultados de un estudio publicado recientemente, los pacientes adultos de especialidades comunes que desarrollaron infecciones hospitalarias (IH) tuvieron una estancia hospitalaria 2,5 veces mas prolongada e incurrieron en costes hospitalarios tres veces mas altos y, tras recibir el alta del hospital, incurrieron en costes mas altos de medicos generales, atencion sanitaria y hospitalaria local que los pacientes no infectados (1). El estudio, a cargo del Servicio de Laboratorio de Salud Publica (Public Health Laboratory Service) y de la Escuela de Higiene y Medicina Tropical de Londres (London School of Hygiene and Tropical Medicine) para la Secretaria de Sanidad (Department of Health) del Reino Unido (RU), tambien revelo que los pacientes infectados incurrian en unos costes personales mas altos y se reincorporaban a su actividad diaria o a su trabajo habitual mas tarde que los pacientes no infectados (1).
Aumento de sífilis na Finlândia relacionado com a epidemia Russa
Authors: E Hilthunen-Back, O Haikala, P Koskela, T Reunala
Journal: Eurosurveillance (1996)

No inicio dos anos noventa, somente 30 a 40 novos casos serologicamente confirmados de sifilis eram notificados anualmente na Finlândia. Tipicamente os doentes de sifilis eram homens heterosexuais que contraiam a doenca no estrangeiro. Desde 1993, a incidencia desta doenca tem aumentado (ver figura). Em 1995, um total de 118 novos casos foram diagnosticados, o que e quase o dobro do verificado em 1994 (63 casos). Trinta e sete por cento de todos os doentes diagnosticados em 1995 eram mulheres, 77% das quais se infectaram na Finlândia. Sessenta e cinco por cento dos homens diagnosticados em 1995 infectaram-se no estrangeiro, 51% na Russia (1). A maioria dos casos de 1995 foram detectados no sul da Finlândia ou no sudeste, junto a fronteira com a Russia (2). Um conglomerado de 30 casos foi identificado na cidade de Tempere, situada no centro da Finlândia. As origens deste surto local foram tres homens, que contrairam a doenca na Russia.
Tatouages, maquillage permanent et piercings à Amsterdam ; les recommandations, la loi et la surveillance
Authors: J Worp, A Boonstra, R A Coutinho, J A R van den Hoek
Journal: Eurosurveillance (2006)

Le tatouage, les piercings et le maquillage permanent connaissent un succes grandissant. L’article suivant decrit les methodes utilisees dans ces pratiques et les risques qui y sont associes, ainsi que les recommandations et le contenu des recommandations emises par le Service municipal de sante d’Amsterdam (Pays-Bas) pour reduire les risques d’infections, les lois regissant la ville d’Amsterdam, et le resultat de la surveillance des studios de tatouage et de piercing.
TCT-426 CT predictor of periprocedural stroke related to transcatheter aortic valve replacement.
Authors: Masaki Miyasaka, Rahul Sharma, Sharjeel Israr, Hiroyuki Kawamori, Sunghan Yoon, Yigal Abramowitz, Tomoki Ochiai, Takahiro Nomura, Tanya Rami, Daniel Berman, Mamoo Nakamura, Wen Cheng, Raj Makkar
Journal: Journal of the American College of Cardiology (2017)
Hepatite aguda C em homens homosexuais positivos para o VIH, Paris, França, 2001-2004
Authors: L Gambotti
Journal: Eurosurveillance (2005)

Em 2004, tres servicos hospitalares de Paris informaram o Institut de veille sanitaire de casos recentes de hepatite C aguda em homens que tem relacoes sexuais com outros homens (HSH) infectados pelo VIH (VIH+), nos quais nao se encontraram os modos usuai...
TCT-232 Late clinical outcomes of diabetic patients treated with a novel third-generation drug-eluting stent: Highlights from Inspiron registry
Authors: Guy Prado, Carlos Campos, Vinicius Seleme, Nelson Fundão, Antonio E. Filho, Celso Takimura, Gilberto Marchiori, Jose Mariani, Luiz Kajita, Pedro Horta, Marcus Gama, Silvio Zalc, Paulo Soares, Expedito Ribeiro, Pedro A. Lemos
Journal: Journal of the American College of Cardiology (2017)
Situazione epidemiologica della ESB in Francia - aggiornamento sui bovini nati dopo il bando delle farine animali
Authors: C Ducrot, D Calavas, T Baron, A E Agrech, M Coudert, M Savey
Journal: Eurosurveillance (2000)

L'incidenza dei casi di encefalopatia spongiforme bovina notificati in Francia dal ESB Epidemiological Surveillance Network, negli ultimi anni, e andata aumentando, malgrado le misure adottate in Francia dal 1990 per controllarne la diffusione. Fino al 1o luglio 2000, sono stati identificati 103 casi di ESB, comprendenti 74 casi nati dopo il bando delle farine animali. Questo aumento esprime i cambiamenti avvenuti nel tempo sia nella reale incidenza della malattia sia nella attivita di sorveglianza.
TCT-808 The myocardial salvaging effect of coronary collaterals in chronic total occlusions and its association with expression of vascular endothelial growth factor A
Authors: Yuxiang Dai, Shufu Chang, Chenguang Li, Zheyong Huang, Hao Lu, Juying Qian, Junbo Ge
Journal: Journal of the American College of Cardiology (2017)
TCT-120 Aspirin is equivalent to dual antiplatelet therapy after transcatheter aortic valve replacement: a meta-analysis of 11,781 patients
Authors: Yousif Ahmad, Ozan Demir, James Howard, Matthew Shun-Shin, Christopher Cook, Ricardo Petraco, Rasha Al-Lamee, Richard Jabbour, Nilesh Sutaria, Ben Ariff, Gajen Kanaganayagam, Andrew Chukwuemeka, Jon Anderson, Darrel Francis, Jamil Mayet, Justin Davies, Ghada Mikhail, Iqbal Malik, Sayan Sen
Journal: Journal of the American College of Cardiology (2017)
Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome
Authors: Chammiran Daniel, Albin Widmark, Ditte Rigardt, Marie Öhman
Journal: Genome biology (2017)

Adenosine to inosine (A-to-I) RNA editing has been shown to be an essential event that plays a significant role in neuronal function, as well as innate immunity, in mammals. It requires a structure that is largely double-stranded for catalysis but little is known about what determines editing efficiency and specificity in vivo. We have previously shown that some editing sites require adjacent long stem loop structures acting as editing inducer elements (EIEs) for efficient editing.The glutamate receptor subunit A2 is edited at the Q/R site in almost 100% of all transcripts. We show that efficient editing at the Q/R site requires an EIE in the downstream intron, separated by an internal loop. Also, other efficiently edited sites are flanked by conserved, highly structured EIEs and we propose that this is a general requisite for efficient editing, while sites with low levels of editing lack EIEs. This phenomenon is not limited to mRNA, as non-coding primary miRNAs also use EIEs to recruit ADAR to specific sites.We propose a model where two regions of dsRNA are required for efficient editing: first, an RNA stem that recruits ADAR and increases the local concentration of the enzyme, then a shorter, less stable duplex that is ideal for efficient and specific catalysis. This discovery changes the way we define and determine a substrate for A-to-I editing. This will be important in the discovery of novel editing sites, as well as explaining cases of altered editing in relation to disease.
Single-session EUS-guided hepaticogastrostomy and dual-scope gastroenterostomy: a modified technique for palliative double endoscopic biliary and gastric bypass
Authors: Manuel Mahler, Robin Prieto, Inés Oria, Guido Villa-Gómez, Gustavo Vidales, Manuel Perez-Miranda
Journal: Endoscopy (2017)

A 59-year-old man with unresectable ampullary adenocarcinoma causing gastric outlet and biliary obstruction was palliated by placement of biliary and duodenal self-expandable metal stents (SEMSs). His symptoms relapsed 4 months later and tumor ingrowth was noted through both SEMSs at endoscopy. Single-session endoscopic ultrasound (EUS)-guided biliary drainage and EUS-guided gastroenterostomy were undertaken.
High risk of hepatocellular carcinoma and death in patients with immune-tolerant-phase chronic hepatitis B
Authors: Gi-Ae Kim, Young-Suk Lim, Seungbong Han, Jonggi Choi, Ju Hyun Shim, Kang Mo Kim, Han Chu Lee, Yung Sang Lee
Journal: Gut (2017)

Objective High serum HBV DNA levels are associated with high risks of hepatocellular carcinoma (HCC) and cirrhosis in patients with chronic hepatitis B (CHB). Although the immune-tolerant (IT) phase is characterised by high circulating HBV DNA levels, it remains unknown whether antiviral treatment reduces risks of HCC and mortality. Design This historical cohort study included HBeAg-positive patients with CHB with high HBV DNA levels (≥20 000 IU/mL) and no evidence of cirrhosis at a tertiary referral hospital in Korea from 2000 to 2013. The clinical outcomes of 413 untreated IT-phase patients with normal alanine aminotransferase (ALT) levels (females, &lt;19 IU/mL; males, &lt;30 IU/mL) were compared with those of 1497 immune-active (IA)-phase patients (ALT ≥80 IU/mL) treated with nucleos(t)ide analogues. Results The IT group was significantly younger than the IA group (mean age, 38 vs 40 years at baseline, p=0.04). The 10-year estimated cumulative incidences of HCC (12.7% vs 6.1%; p=0.001) and death/transplantation (9.7% vs 3.4%; p&lt;0.001) were significantly higher in the IT group than the IA group. In multivariable analyses, the IT group showed a significantly higher risk of HCC (HR 2.54; 95% CI 1.54 to 4.18) and death/transplantation (HR 3.38; 95% CI 1.85 to 6.16) than the IA group, which was consistently identified through inverse probability treatment weighting, propensity score-matched and competing risks analyses. Conclusions Untreated IT-phase patients with CHB had higher risks of HCC and death/transplantation than treated IA-phase patients. Unnecessary deaths could be prevented through earlier antiviral intervention in select IT-phase patients.