tbuckley/cabot-search huggingface dataset:
Vacunación contra el meningococo C en España con vacuna conjugada: una decisión epidemiológica y microbiológica
Authors: R Cano, A Larrauri, S Mateo, B Alcalá, C Salcedo, J A Vázquez
Journal: Eurosurveillance (2004)

La nueva vacuna conjugada frente al meningococo C se licencio en Espana en el ano 2000 y se introdujo en el calendario de vacunacion infantil. Ademas, se realizo una campana de vacunacion en los ninos menores de seis anos de edad en todo el pais. Como consecuencia, la incidencia de enfermedad meningococica por serogrupo C ha descendido de forma importante en las tres ultimas temporadas epidemiologicas. El riesgo de sufrir la enfermedad por dicho serogrupo ha descendido un 58%, en relacion con la incidencia de la temporada previa a la introduccion de la vacuna. Tambien hubo un importante descenso en la mortalidad. En la temporada 2002-2003 se produjeron tres fallecimientos por serogrupo C en los grupos de edad vacunados, en comparacion con las 30 defunciones ocurridas en las mismas edades en la temporada previa a la introduccion de la vacuna. La cobertura vacunal en la campana fue superior al 92%. En los programas de rutina de los anos 2001, 2002 y 2003, la cobertura oscilo entre el 90% y el 95%. En los tres ultimos anos, se han producido 111 casos de enfermedad meninigococica por serogrupo C en los grupos de edad susceptibles de vacunacion. Los fallos vacunales ocurrieron, principalmente, en la temporada 2002-2003. Ocho (53%) fallos vacunales ocurrieron en ninos vacunados segun el calendario de rutina. Estos datos podrian indicar una perdida de proteccion con el paso del tiempo despues de la vacunacion. Se han aislado varias cepas B:2a:P1.5 (ST-11). Estas cepas pueden tener su origen en las cepas C:2a:P1.5, despues de haber sufrido recombinacion genetica de la capsula, y podrian tener un importante potencial epidemico.
TCT-101 Safety of double antiplatelet therapy as an alternative to warfarin plus aspirin after left atrial appendage device closure - short-term results of WATCHMAN-DAPT multi-center registry
Authors: Grzegorz Smolka, Marcin Demkow, Radoslaw Pracon, Wojtek Wasek, Adam Sukiennik, Wiktor Kuliczkowski, Wojtek Wojakowski, Marek Grygier
Journal: Journal of the American College of Cardiology (2017)
Hyperbaric Oxygen Therapy in the Treatment of Ischemic Lower- Extremity Ulcers in Patients With Diabetes: Results of the DAMO2CLES Multicenter Randomized Clinical Trial
Authors: Katrien T.B. Santema, Robert M. Stoekenbroek, Mark J.W. Koelemay, Jim A. Reekers, Laura M.C. van Dortmont, Arno Oomen, Luuk Smeets, Jan J. Wever, Dink A. Legemate, Dirk T. Ubbink, M. Reichart, R. Balm, M.E. Bodegom, J.L. van Wanroij, S. ten Raa, M.C. Willems, P. Klemm, F.G. de Valk, J.J. Wever, I. Hulst, J.C.A. de Mol van Otterloo, E.A. Lenselink, A.W.F. Vos, R.C. van Nieuwenhuizen, A.C. Vahl, L. Smeets, D. Nio, J.C.H. van den Heuvel, A. Oomen, J. Swinkels, P.W.H.E. Vriens, C.P.A. van Hees, J.P. van Brussel, N.A. Koedam, S. Buijk, P. Lauwers, L.M.C. van Dortmont, J.H. Nederhoed, J.K. Kievit, A.M. Wiersema, B.P. Vierhout, J.G. van Baal, R.A. van Hulst, R. Groot, P.A.M. Everts, R.D. Bol Raap, O. Boonstra, K. G. Monsieurs, T.P. van Rees Vellinga, A.H. Zwinderman, J.F. Hamming, E.J.G. Peters
Journal: Diabetes Care (2017)

OBJECTIVE Conflicting evidence exists on the effects of hyperbaric oxygen therapy (HBOT) in the treatment of chronic ischemic leg ulcers. The aim of this trial was to investigate whether additional HBOT would benefit patients with diabetes and ischemic leg ulcers. RESEARCH DESIGN AND METHODS Patients with diabetes with an ischemic wound (n = 120) were randomized to standard care (SC) without or with HBOT (SC+HBOT). Primary outcomes were limb salvage and wound healing after 12 months, as well as time to wound healing. Other end points were amputation-free survival (AFS) and mortality. RESULTS Both groups contained 60 patients. Limb salvage was achieved in 47 patients in the SC group vs. 53 patients in the SC+HBOT group (risk difference [RD] 10% [95% CI −4 to 23]). After 12 months, 28 index wounds were healed in the SC group vs. 30 in the SC+HBOT group (RD 3% [95% CI −14 to 21]). AFS was achieved in 41 patients in the SC group and 49 patients in the SC+HBOT group (RD 13% [95% CI −2 to 28]). In the SC+HBOT group, 21 patients (35%) were unable to complete the HBOT protocol as planned. Those who did had significantly fewer major amputations and higher AFS (RD for AFS 26% [95% CI 10–38]). CONCLUSIONS Additional HBOT did not significantly improve complete wound healing or limb salvage in patients with diabetes and lower-limb ischemia.
TCT-129 Long-term Follow-up of BRS Implantation for Complex Coronary Lesions: A Multicentre Experience
Authors: Damiano Regazzoli, Azeem Latib, Babu Ezhumalai, Akihito Tanaka, Pier Pasquale Leone, Marco Ancona, Antonio Mangieri, Francesco Giannini, Satoru Mitomo, Ashok Seth, Antonio Colombo
Journal: Journal of the American College of Cardiology (2017)
Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age
Authors: Gayan Bowatte, Bircan Erbas, Caroline J. Lodge, Luke D. Knibbs, Lyle C. Gurrin, Guy B. Marks, Paul S. Thomas, David P. Johns, Graham G. Giles, Jennie Hui, Martine Dennekamp, Jennifer L. Perret, Michael J. Abramson, E. Haydn Walters, Melanie C. Matheson, Shyamali C. Dharmage
Journal: European Respiratory Journal (2017)

Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene-environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathione S-transferase gene variants.Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of the GSTT1 null and GSTP1 val/val or ile/val genotypes. Over the 5-year period, higher NO2 exposures were associated with increased current asthma prevalence. Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with the GSTT1 genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.
State of health and care in England
Authors: Chris Ham
Journal: BMJ (2017)

Introduction There is paucity of data on safety, efficacy and outcomes of modified ATT regimens in patients with CLD.  Aims and Objectives To study the efficacy and safety of treatment regimens for compensated (Group 1) and decompensated (group 2) liver disease group.  Methods This was a randomized open labelled pilot study. Patients were given 6 months of ATT randomized to Isoniazid + Rifampicin + pyrazinamide + Ethambutol (HRZE) or Isoniazid + Rifampicin + Levofloxacin + Ethambutol (HRLE) in group 1 and 9 months of ATT randomized to Isoniazid + Levofloxacin + Ethambutol (HLE) or Rifampicin + Levofloxacin + Ethambutol (RLE) in group 2 respectively. Successful completion of ATT, development of hepatotoxicity, therapeutic response and overall survival was monitored.  Results A total of 129 patients -60 in Group1 and 69 in Group 2 were included. Around 80 and 75 percent of patients in group 1 and 2 respectively were successfully treated with these regimens. The 6 month survival and incidence of hepatotoxicity was 98% vs 81% and 12.7% vs 13% in group 1 and 2 respectively (p-0.347). Mean therapeutic response was seen in 80 days vs 112 days (p-0.023) in group 1 and 2 respectively. High baseline AST and development of hepatotoxicity in HLE arm were found to be inversely correlated with survival (p   Conclusions Treatment of TB in CLD is difficult and challenging, nevertheless success can be achieved with carefully planned treatment regimens and close monitoring. Low dose pyrazinamide can be used safely in compensated CLD; although the findings needs to be substantiated in further well controlled studies.
Excretion of Sulfa Drugs by the Stomachs of Normal Persons and Patients with Gastritis, Peptic Ulcer, and Gastric Cancer
Authors: Leon Schiff
Journal: JNCI Journal of the National Cancer Institute (1945)

Journal Article Excretion of Sulfa Drugs by the Stomachs of Normal Persons and Patients with Gastritis, Peptic Ulcer, and Gastric Cancer Get access Leon Schiff Leon Schiff associate professor of medicine University of Cincinnati Medical School Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 5, Issue 5, April 1945, Pages 369–370, https://doi.org/10.1093/jnci/5.5.369 Published: 01 April 1945
TCT-50 Impact of Anticoagulation Therapy on Valve Hemodynamic Deterioration Following Transcatheter Aortic Valve Replacement
Authors: Maria Del Trigo, Antonio Munoz-Garcia, Azeem Latib, Vincent Auffret, Harindra Wijeysundera, Luis Nombela-Franco, Enrique Gutierrez Ibanes, Asim Cheema, Vicente Serra, Ignacio Amat-Santos, Joelle Kefer, Luis Benitez, Florence Leclercq, Pilar Jimenez Quevedo, Philippe Pibarot, Josep Rodés-Cabau
Journal: Journal of the American College of Cardiology (2017)
RAS mutations testing and choice of first-line treatment for metastatic colorectal cancer patients in our institute
Authors: Takashi Iwata, Eiki Ojima, Tomomi Mohri, Tomohumi Noguchi, Kiyoshi Hashimoto, Mikio Kawamura, Hideki Watanabe, Hideki Ito, Tetsuya Ikeda, Hitoshi Tonouchi
Journal: Annals of Oncology (2017)
TCT-211 Local intravascular delivery of low-density-lipoprotein cholesterol causes increased neointimal thickening in the healthy porcine coronary model. Insights into development of model of atherosclerosis
Authors: Piotr Buszman, Bartlomiej Orlik, Krzysztof Milewski, Mateusz Kachel, Tomasz Roleder, Wojtek Wojakowski, Magdalena Michalak, Adam Janas, Filip Polczyk, Frank Kolodgie, Renu Virmani, Paweł Buszman
Journal: Journal of the American College of Cardiology (2017)
Therapeutic Effects of Targeted PPARɣ Activation on Inflamed High-Risk Plaques Assessed by Serial Optical Imaging In Vivo
Authors: Jah Yeon Choi, Jiheun Ryu, Hyun Jung Kim, Joon Woo Song, Joo Hee Jeon, Dae-Hee Lee, Dong Joo Oh, Dae-Gab Gweon, Wang-Yuhl Oh, Hongki Yoo, Kyeongsoon Park, Jin Won Kim
Journal: Theranostics (2017)

Rationale: Atherosclerotic plaque is a chronic inflammatory disorder involving lipid accumulation within arterial walls. In particular, macrophages mediate plaque progression and rupture. While PPARγ agonist is known to have favorable pleiotropic effects on atherogenesis, its clinical application has been very limited due to undesirable systemic effects. We hypothesized that the specific delivery of a PPARγ agonist to inflamed plaques could reduce plaque burden and inflammation without systemic adverse effects. Methods: Herein, we newly developed a macrophage mannose receptor (MMR)-targeted biocompatible nanocarrier loaded with lobeglitazone (MMR-Lobe), which is able to specifically activate PPARγ pathways within inflamed high-risk plaques, and investigated its anti-atherogenic and anti-inflammatory effects both in in vitro and in vivo experiments. Results: MMR-Lobe had a high affinity to macrophage foam cells, and it could efficiently promote cholesterol efflux via LXRα-, ABCA1, and ABCG1 dependent pathways, and inhibit plaque protease expression. Using in vivo serial optical imaging of carotid artery, MMR-Lobe markedly reduced both plaque burden and inflammation in atherogenic mice without undesirable systemic effects. Comprehensive analysis of en face aorta by ex vivo imaging and immunostaining well corroborated the in vivo findings. Conclusion: MMR-Lobe was able to activate PPARγ pathways within high-risk plaques and effectively reduce both plaque burden and inflammation. This novel targetable PPARγ activation in macrophages could be a promising therapeutic strategy for high-risk plaques.
Copper Manganese Sulfide Nanoplates: A New Two-Dimensional Theranostic Nanoplatform for MRI/MSOT Dual-Modal Imaging-Guided Photothermal Therapy in the Second Near-Infrared Window
Authors: Kaimei Ke, Wen Yang, Xiaoli Xie, Rui Liu, Li-Li Wang, Wei-Wen Lin, Guoming Huang, Chun-Hua Lu, Huang-Hao Yang
Journal: Theranostics (2017)

Multifunctional nanoplatforms with integrated diagnostic and therapeutic functions have attracted tremendous attention.Especially, the second near-infrared (NIR-II) light response-based nanoplatforms hold great potential in cancer theranostic applications, which is because the NIR-II window provides larger tissue penetration depth and higher maximum permissible exposure (MPE) than that of the well-studied first near-infrared (NIR-I) window.Herein, we for the first time present a two-dimensional (2D)-nanoplatform based on Cu2MnS2 nanoplates (NPs) for magnetic resonance imaging (MRI)/multispectral optoacoustic tomography (MSOT) dual-modal imaging-guided photothermal therapy (PTT) of cancer in the NIR-II window.Methods: Cu2MnS2 NPs were synthesized through a facile and environmentally friendly process.A series of experiments, including the characterization of Cu2MnS2 NPs, the long-term toxicity of Cu2MnS2 NPs in BALB/c nude mice, the applications of Cu2MnS2 NPs for in vitro and in vivo MRI/MSOT dual-modal imaging and NIR-II PTT of cancer were carried out.Results: The as-synthesized Cu2MnS2 NPs exhibit low cytotoxicity, excellent biocompatibility as well as high photothermal conversion efficiency (~49.38%) and outstanding photostability.Together with their good T1-shortening effect and strong absorbance in the NIR-I and NIR-II region, the Cu2MnS2 NPs display high-contrast imaging performance both in MRI and MSOT (900 nm laser source).Moreover, the subsequent in vitro and in vivo results demonstrate that the Cu2MnS2 NPs possess excellent PTT efficacy under 1064 nm laser irradiation with a low power density (0.6 W cm -2 ).In addition, the detailed long-term toxicity studies further confirming the safety of Cu2MnS2 NPs in vivo.Conclusion: We have developed a new 2D Cu2MnS2 NPs as multifunctional theranostic agents for MRI/MSOT dual-modal imaging-guided PTT of cancer in the NIR-II window.Such biocompatible Cu2MnS2 NPs might provide a new perspective for exploring new 2D-based nanoplatforms with improved properties for clinical applications in the future.
TCT-657 The PRAGMATIC Study: A Prospective Randomized Clinical Trial comparing Radial Artery Intimal Hyperplasia resulting from a 7F Sheathless Guide (Mach 1TM) vs. a 6F Transradial Sheath/Guide Combination in Coronary Intervention
Authors: Vishal Dahya, Thomas Noel, Dan McGee, Matthew Parkin, John Katopodis, William Dixon, Patty Knap, Katherine Gearld, James Campbell, Ashley Meredith, Wayne Batchelor
Journal: Journal of the American College of Cardiology (2017)
Retrospective analysis of peripheral T cell lymphomas
Authors: Satoshi Kaito, Yusuke Kanemasa, Yuki Sasaki, Toshihiro Okuya, Tsukasa Yamaguchi, Miho Tamura, Tatsu Shimoyama, Yashshi Omuro, Tunekazu Hishima, Yoshiharu Maeda
Journal: Annals of Oncology (2017)
Vigilancia de las resistencias a fármacos antituberculosos en Europa, 1999
Authors: A Infuso, D Antoine, P Barboza, D Falzon
Journal: Eurosurveillance (2002)

A excepcion de Israel, los datos representativos de Europa Occidental y Central indican niveles sistematicamente bajos en las resistencias a la isoniazida (0-9,3%) o la rifampicina (0-2,1%) y en las multirresistencias (MDR) (0-2,1%) de los nuevos casos de
TCT-40 Outcome Of Patients Undergoing Trans-Catheter Implantation Of Aortic Valve With Previous Mitral Valve Prosthesis (Optimal Study)
Authors: Luca Baldetti, Francesco Giannini, Azeem Latib, Didier Tchetche, Chiara De Biase, Giuseppe Tarantini, Chiara Fraccaro, Corrado Tamburino, Marco Barbanti, Nicolas Van Mieghem, Amit Segev, Anna Sonia Petronio, Antonio Mangieri, Damiano Regazzoli, Marco Ancona, Antonio Colombo
Journal: Journal of the American College of Cardiology (2017)
PAB possessing anti-angiogenic effect attributed by inhibition of tubulin polymerization.
Authors: Yunguang Tong, Xiongwen Zhang, Fang Tian, Jianming Yue, Jian Ding
Journal: Cancer Research (2004)

2374   Pseudolarix acid B (PAB) was isolated from the traditional Chinese medical plant  Pseudolarix kaempferi  Gorden (Pinaceae) and originally identified as an early pregnancy-terminating agent. Angiogenesis, the formation of new blood vessels from the endothelium of the existing vasculature, is implicated in female reproductive system and embryo development. We explored the effect of PAB on angiogenesis and the underlying mechanism. Our experiments showed treatment with PAB for 72 h resulted in a dose-dependent (0.313-5μM) inhibition of Human microvessel enthothelial cell (HMEC) with an IC 50  of 0.49μM and a time-dependent proliferation inhibition manner at 5μM. PAB also exhibited the inhibition of migration and tube formation on HMEC in a dose dependent manner with IC 50 s of 0.89μM and 0.39μM respectively. In rat aorta culture PAB significantly inhibited the microvessel outgrowth. Treatment with PAB at concentration 5μM led to only a very few microvessel sprout. The anti-angiogenic effect of PAB was further confirmed by Chicken chorioallantoic membrane (CAM) assay. Cytoskeleton especially microtubule and actin filament play important roles in mitosis, cell signaling, and motility that are badly needed in the process of angiogenesis. Flow cytometry showed that PAB caused HMEC cell cycle arrest at G2/M phase. Immunocytochemical study revealed that PAB significantly disrupted both microtubule and microfilament in HMEC cells. The tubulin and actin polymerization assay in cell-free system displayed that PAB directly acts on tubulin while have no effect on actin. The actin changes as well as the subsequent cell morphology changes in PAB treated HMEC cells could be blocked by Rho kinase inhibitor, indicating the effect of PAB on cellular actin was in an indirect manner. Further investigation was focused on the manner of PAB interact with tubulin. We found PAB turned tubulin structure in a state different with that induced by known tubulin polymerization inhibitors such as colchicine and vinblastine. The tubulin structure was induced into a loose state by PAB, which was marked by the increasement of hydrophobicity and enhancement of tubulin sulfhydryls reactivity. Subsequent studies demonstrated that PAB did not bind to colchicines binding site as well as the vinblastine binding site, suggesting its binding sites on tubulin maybe a novel one. In conclusion, PAB, a natural derived compound, possesses significantly anti-angiogenic effect. PAB causes unique changes of tubulin protein by binding to a novel site on tubulin and inhibits tubulin polymerization both in vitro and in vivo, which may responsible for its anti-angiogenic effect.
The chaperone dynein LL1 mediates cytoplasmic transport of empty and mature hepatitis B virus capsids
Authors: Quentin Osseman, Lara Gallucci, Shelly Au, Christian Cazenave, Elodie Berdance, Marie-Lise Blondot, Aurélia Cassany, Dominique Bégu, Jessica Ragues, Cindy Aknin, Irina Sominskaya, Andris Dishlers, Birgit Rabe, Fenja Anderson, Nelly Panté, Michael Kann
Journal: Journal of Hepatology (2017)
Socioecological factors are linked to changes in prevalence of contempt over time
Authors: Michael E W Varnum, Igor Grossmann
Journal: Behavioral and Brain Sciences (2017)

Abstract Gervais &amp; Fessler argue that the perceived legitimacy of contempt has declined over time in the United States, citing evidence of a decrease in the frequency of its use in the American English corpus. We argue that this decline in contempt, as reflected in cultural products, is linked to shifts in key socioecological features previously associated with other forms of cultural change.
Changes in the microarchitecture of the pancreatic cancer stroma are linked to neutrophil-dependent reprogramming of stellate cells and reflected by diffusion-weighted magnetic resonance imaging
Authors: Philipp Mayer, Christine Dinkic, Ralf Jesenofsky, Miriam Klauss, Peter Schirmacher, Ulrike Dapunt, Thilo Hackert, Florian Uhle, G Maria Hänsch, Matthias M Gaida
Journal: Theranostics (2017)

In pancreatic cancer (PDAC) intratumor infiltration of polymorphonuclear neutrophils (PMN) is associated with histologically apparent alterations of the tumor growth pattern. The aim of this study was to examine possible associations between PMN infiltration, tumor microarchitecture, and water diffusivity in diffusion-weighted magnetic resonance imaging (DW-MRI), and to further asses the underlying mechanisms. Methods: DW-MRI was performed in 33 PDAC patients prior to surgery. In parallel, tissue specimen were examined histologically for growth pattern, azurocidin-positive PMN infiltrates, and the presence of alpha-smooth muscle actin (α-SMA) and metalloproteinase 9 (MMP9)-positive myofibroblastic cells. For confirmation of the histological findings, a tissue microarray of a second cohort of patients (n=109) was prepared and examined similarly. For in vitro studies, the pancreatic stellate cell line RLT was co-cultivated either with isolated PMN, PMN-lysates, or recombinant azurocidin and characterized by Western blot, flow cytometry, and proteome profiler arrays. Results: Tumors with high PMN density showed restricted water diffusion in DW-MRI and histologic apparent alterations of the tumor microarchitecture (microglandular, micropapillary, or overall poorly differentiated growth pattern) as opposed to tumors with scattered PMN. Areas with altered growth pattern lacked α-SMA-positive myofibroblastic cells. Tissue microarrays confirmed a close association of high PMN density with alterations of the tumor microarchitecture and revealed a significant association of high PMN density with poor histologic grade of differentiation (G3). In vitro experiments provided evidence for direct effects of PMN on stellate cells, where a change to a spindle shaped cell morphology in response to PMN and to PMN-derived azurocidin was seen. Azurocidin incorporated into stellate cells, where it associated with F-actin. Down-regulation of α-SMA was seen within hours, as was activation of the p38-cofilin axis, up-regulation of MMP9, and acquisition of intracellular lipid droplets, which together indicate a phenotype switch of the stellate cells. Conclusion: In PDAC, PMN infiltrates are associated with alterations of the tumor microarchitecture. As a causal relationship, we propose a reprogramming of stellate cells by PMN-derived azurocidin towards a phenotype, which affects the microarchitecture of the tumor.
TCT-432 Association of Primary Insurance Status with Use of Revascularization and In-hospital Outcomes in Patients with Non-ST-segment Elevation Myocardial Infarction in the United States
Authors: Tanush Gupta, Dhaval Kolte, Sahil Khera, Kashish Goel, Ankur Kalra, Pedro Villablanca, Anna Bortnick, Herbert Aronow, J. Dawn Abbott, Gregg Fonarow, Chet Rihal, None Mark Menegus, Mario Garcia, Deepak Bhatt
Journal: Journal of the American College of Cardiology (2017)
Pourquoi les adultes contractent-ils la diphtérie ?
Authors: J Tomaszunas-Blaszczyk, A Galazka
Journal: Eurosurveillance (1997)

Lorsque la diphterie etait une maladie courante, elle touchait surtout les enfants. En regle, au moins 40% des cas de diphterie concernaient les enfants de moins de 5 ans et environ 70% des cas des enfants de moins de 15 ans. Ce schema classique des cas de diphterie etait observe dans de nombreux pays dont les Etats-Unis de 1908 a 1934 (1), l'Allemagne de 1929 a 1931 (2) et l'Angleterre et le Pays de Galles de 1936 a 1937 (3).