tbuckley/cabot-search huggingface dataset:
DUODENAL DUPLICATION CYST TREATED ENDOSCOPICALLY AFTER AN EPISODE OF INFECTION
Authors: M Sousa, L Proença, S Fernandes, A Costa, J Rodrigues, J Silva, J Carvalho
Journal: Endoscopy (2018)

A 21-year-old woman was admitted to the emergency department for acute abdominal pain. Laboratory tests revealed leukocytosis (16.35 × 103/uL) and elevated C Reactive Protein (20.53 mg/dL) with normal amilase and lipase. An ultrasound and subsequently a computed tomography scan showed a duodenopancreatic cystic inflammatory lesion with 30 × 24 mm in the third portion of the duodenum with edema of the surrounding mucosa and fat, corresponding to an infected duplication cyst or an infected diverticulum. Antibiotics were initiated and she was discharged asymptomatic after 13 days and referred for consultation.
Verrucous Carcinoma of the Esophagus
Authors: C. Ereño, J. L. Lopez, A. Loizate, F. J. Bilbao
Journal: Endoscopy (2001)

Figure 1A 65-year-old woman presented with a history of long-standing dysphagia. During endoscopy, a stenosing verrucous lesion was found in the middle third of the esophagus.
Intraductal Papillary Mucinous Neoplasm: Is it safe to watch and wait?
Authors: M Al-Haddad, H Bonatti, S Pungpapong, K Noh, S Gross, M Raimondo, T Woodward, M Wallace
Journal: Endoscopy (2006)

Introduction: Intraductal papillary mucinous neoplasms of the pancreas (IPMN) are increasingly recognized in clinical practice. Published literature suggests that up to 45% of IPMN are malignant and should be resected however these data are based on larger, primarily symptomatic lesions. The risk of malignancy and need for surgical resection in smaller, lower risk lesions is not known.
Targeting the accomplice to thwart the culprit: a new target for the prevention of amyloid deposition
Authors: David R. Borchelt
Journal: Journal of Clinical Investigation (2018)

Inheritance of the E4 allele of the apolipoprotein E gene (APOE4) substantially increases the risk of developing late-onset Alzheimer disease (AD). A large body of evidence has firmly established a role for apoE in modulating the risk of developing the amyloid plaque pathology that is pathognomonic for AD. In this issue of the JCI, Liao and colleagues discovered that antibodies against a nonlipidated form of apoE4 are highly effective in delaying the deposition of amyloid β (Aβ) peptides in mouse models of AD pathology. Using a combination of passive immunization and viral-mediated expression of recombinant antibodies, the authors show that Fc receptor–mediated clearance of the nonlipidated apoE4 was critical in delaying Aβ deposition. Collectively, this study identifies a new therapeutic target that could be exploited to prevent, or possibly reverse, the Aβ pathology of AD.
DISTORTION-FREE IMAGING THROUGH WAVEFRONT SENSING TECHNIQUE IN GASTROINTESTINAL ENDOSCOPE: IN VITRO STUDY
Authors: JM Lee, G Min, W Kim, SJ Choi, JM Lee, SH Kim, HS Choi, ES Kim, B Keum, YT Jeen, HJ Chun, HS Lee, CD Kim
Journal: Endoscopy (2018)

Precise measurement of lesion is important in the endoscopic examination. An endoscope is usually equipped with a wide-angle lens (Fish eye lens) which create hidden distortion of image by creating a relative compression of points in its periphery.. In this study, we aims to compare difference between lens applied wavefront sensing technique and conventional lens.
Comparison of endoscopic suturing techniques for closure of the transgastric entrance site for NOTES procedure
Authors: JR Armengol Miro, M Abu-Suboh Abadia, J Dot Bach, M Masachs Peracaula, J Armengol Bertroli, A Benages Curell, JC Salord, SV Kantsevoy
Journal: Endoscopy (2012)

Background: Endoscopic closure of the transgastric wall incision created to enter the peritoneal cavity remains problematic. Several techniques (closure with endoscopic clips, T-bars, stapling devices, etc.) have not achieved quality of closure comparable to surgical suturing.
Case 10-2018: An 84-Year-Old Man with Painless Unilateral Testicular Swelling
Authors: Ryan W. Thompson, HeiShun Yu, Douglas M. Dahl, Rocio M. Hurtado, Dipti P. Sajed
Journal: New England Journal of Medicine (2018)

An 84-year-old man presented with a 6-week history of painless right testicular swelling. He had no fever or systemic symptoms. Ultrasonography revealed marked asymmetric enlargement and hypervascularity of the right testicle. A diagnostic procedure was performed.
WHICH IS BETTER, TO STOP BALLOON ASSISTED ENTEROSCOPE ON FINDING A LESION OR TO COMPLETE AS FAR AS POSSIBLE “A CASE SERIES STUDY”
Authors: M Wahba, A Farag, W Aerf, G Habib
Journal: Endoscopy (2018)

Balloon-assisted enteroscopy (BAE) is an advanced procedure to evaluate the entire small bowel. It allows better visualization, biopsy from the identified lesions and application of therapeutic techniques, BAE is a novel time consuming procedure. it require validation of criteria for successful examination. The aim of our study is to evaluate the feasibility and usefulness of continuing enteroscope as far as possible after a finding lesion that explains the clinical presentation.
IS IT REASONABLE TO PROPOSE AN ENDOSCOPIC MUCOSAL RESECTION FOR BARRET'S OESOPHAGUS WITH HIGH GRADE DYSPLASIA ON THE BIOPSIES?
Authors: JM Gonzalez, JP Casanova, E Bories, S Garcia, M Giovannini, M Barthet
Journal: Endoscopy (2018)

Endoscopic mucosal resection (EMR) is currently the treatment for high grade dysplasia (HGD) in Barret's esophagus (BE), based on biopsies. The aim was to evaluate the discordance between biopsy sample (BS) and EMR specimen in case of HGD, and cytologists’ inter and intra-observatory variability.
Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
Authors: Ying-Nai Wang, Heng-Huan Lee, Chao-Kai Chou, Wen-Hao Yang, Yongkun Wei, Chun-Te Chen, Jun Yao, Jennifer L. Hsu, Cihui Zhu, Haoqiang Ying, Yuanqing Ye, Wei-Jan Wang, Seung-Oe Lim, Weiya Xia, How-Wen Ko, Xiuping Liu, Chang-Gong Liu, Xifeng Wu, Huamin Wang, Donghui Li, Laura R. Prakash, Matthew H. Katz, Yaan Kang, Michael Kim, Jason B. Fleming, David Fogelman, Milind Javle, Anirban Maitra, Mien-Chie Hung
Journal: Cancer Cell (2018)
Genetic predisposition to obesity is associated with asthma in US Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos
Authors: Y. Guo, J.‐Y. Moon, C. C. Laurie, K. E. North, L. A. P. Sanchez‐Johnsen, S. Davis, B. Yu, S. M. Nyenhuis, R. Kaplan, D. Rastogi, Q. Qi
Journal: Allergy (2018)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
ENDOSCOPIC TREATMENT OF BILIARY COMPLICATIONS OF HYDATID CYST OF THE LIVER: A STUDY OF 45 CASES
Authors: K Agar, M Medhioub, S Jardak, L Hamzaoui, A Khsiba, M Msaddek Azouz
Journal: Endoscopy (2018)

The liver hydatid cyst (LHC) is a parasitic disease which remains endemic in North African countries. It can cause severe morbidity due to biliary complications. The aim of our study is to evaluate the efficacy of endoscopic treatment of biliary complications of LHC.
Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
Authors: Janel O. Johnson, Jessica Mandrioli, Michael Benatar, Yevgeniya Abramzon, Vivianna M. Van Deerlin, John Q. Trojanowski, J. Raphael Gibbs, Maura Brunetti, Susan Gronka, Joanne Wuu, Jinhui Ding, Leo McCluskey, Maria Martinez-Lage, Dana Falcone, Dena G. Hernandez, Sampath Arepalli, Sean Chong, Jennifer C. Schymick, Jeffrey Rothstein, Francesco Landi, Yong-Dong Wang, Andrea Calvo, Gabriele Mora, Mario Sabatelli, Maria Rosaria Monsurrò, Stefania Battistini, Fabrizio Salvi, Rossella Spataro, Patrizia Sola, Giuseppe Borghero, Giuliana Galassi, Sonja W. Scholz, J. Paul Taylor, Gabriella Restagno, Adriano Chiò, Bryan J. Traynor
Journal: Neuron (2011)
RESECT AND DISCARD/DIAGNOSE AND DISREGARD STRATEGY FOR COLONIC POLYPS IN A COMMUNITY HOSPITAL: ARE WE ABLE TO IMPLEMENT IT?
Authors: R Azevedo, F Pereira, M Linhares, H Ribeiro, J Pinto, A Caldeira, C Leitão, A Banhudo
Journal: Endoscopy (2018)

The use of Narrow Band Imaging (NBI) technology for in vivo histological prediction of colorectal polyps presents high accuracy in Referral Centers, particularly for diminutive polyps, which could be managed by the “resect and discard” strategy and, for sigmoid and rectum polyps, the “diagnose and disregard” strategy. However, the applicability of this practice in Community Hospitals still needs to be determined.
Stenting for benign esophageal strictures
Authors: P. Siersema
Journal: Endoscopy (2009)

Benign esophageal strictures are a common problem in endoscopic practice. The predominant symptom of patients is dysphagia. The initial treatment option for a benign esophageal stricture is dilation. A subgroup of strictures, i. e., those that are long (> 2 cm), tortuous, and have a narrow diameter, tend to recur and are therefore called refractory. Temporary stent placement, either with a self-expanding metal stent (SEMS) or a self-expanding plastic stent (SEPS), can be considered in these patients. The results obtained so far are disappointing, with long-term clinical resolution of the stricture achieved in less than 50 % of patients. This is mainly due to hyperplastic tissue ingrowth or overgrowth (experienced with SEMS) and stent migration (SEPS). New stent designs are therefore needed for this indication. Initial results show that biodegradable stents have the promise to be useful for refractory benign esophageal strictures; however, this promise needs to be further elucidated in future studies.
Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study
Authors: Yoonyoung Park, Brian T Bateman, Dae Hyun Kim, Sonia Hernandez-Diaz, Elisabetta Patorno, Robert J Glynn, Helen Mogun, Krista F Huybrechts
Journal: BMJ (2018)

<h3>Abstract</h3> <h3>Objective</h3> To compare the risk of in-hospital mortality associated with haloperidol compared with atypical antipsychotics in patients admitted to hospital with acute myocardial infarction. <h3>Design</h3> Cohort study using a healthcare database. <h3>Setting</h3> Nationwide sample of patient data from more than 700 hospitals across the United States. <h3>Participants</h3> 6578 medical patients aged more than 18 years who initiated oral haloperidol or oral atypical antipsychotics (olanzapine, quetiapine, risperidone) during a hospital admission with a primary diagnosis of acute myocardial infarction between 2003 and 2014. <h3>Main outcome measure</h3> In-hospital mortality during seven days of follow-up from treatment initiation. <h3>Results</h3> Among 6578 patients (mean age 75.2 years) treated with an oral antipsychotic drug, 1668 (25.4%) initiated haloperidol and 4910 (74.6%) initiated atypical antipsychotics. The mean time from admission to start of treatment (5.3 <i>v</i> 5.6 days) and length of stay (12.5 <i>v</i> 13.6 days) were similar, but the mean treatment duration was shorter in patients using haloperidol compared with those using atypical antipsychotics (2.4 <i>v</i> 3.9 days). 1:1 propensity score matching was used to adjust for confounding. In intention to treat analyses with the matched cohort, the absolute rate of death per 100 person days was 1.7 for haloperidol (129 deaths) and 1.1 for atypical antipsychotics (92 deaths) during seven days of follow-up from treatment initiation. The survival probability was 0.93 in patients using haloperidol and 0.94 in those using atypical antipsychotics at day 7, accounting for the loss of follow-up due to hospital discharge. The unadjusted and adjusted hazard ratios of death were 1.51 (95% confidence interval 1.22 to 1.85) and 1.50 (1.14 to 1.96), respectively. The association was strongest during the first four days of follow-up and decreased over time. By day 5, the increased risk was no longer evident (1.12, 0.79 to 1.59). In the as-treated analyses, the unadjusted and adjusted hazard ratios were 1.90 (1.43 to 2.53) and 1.93 (1.34 to 2.76), respectively. <h3>Conclusion</h3> The results suggest a small increased risk of death within seven days of initiating haloperidol compared with initiating an atypical antipsychotic in patients with acute myocardial infarction. Although residual confounding cannot be excluded, this finding deserves consideration when haloperidol is used for patients admitted to hospital with cardiac morbidity.
Abstract 14207: Cryoballoon or Irrigated Radiofrequency Ablation for Atrial Fibrillation: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: João Carmo, Francisco M Costa, Diogo Cavaco, Jorge Ferreira, Nicodemus Lopes, Pedro Carmo, Francisco Morgado, Pedro Adragão
Journal: Circulation (2016)

Background:  Pulmonary-vein isolation by means of catheter ablation is the treatment of choice for drug-refractory atrial fibrillation (AF). Previous studies suggested that cryoballoon ablation has clinical benefits comparable to those of radiofrequency ablation, but the optimal method remains unclear. We aimed to assess the efficacy and safety of cryoballoon ablation compared with irrigated radiofrequency ablation for the treatment of AF, based on last clinical data.   Methods:  PubMed, Embase and Cochrane databases were searched until April 2016. We included only studies that randomized patients with AF to cryoballoon ablation versus irrigated radiofrequency ablation. The primary clinical outcome was the proportion of patients free from AF at long-term follow-up. The secondary outcomes were procedure time, fluoroscopy time and complications.   Results:  Seven randomized studies were included, comprising 1476 patients (736 received cryoballoon ablation and the remaining 740 received radiofrequency ablation). Cryoballoon ablation was associated with similar proportion of patients free from AF at a mean 13 months follow-up when compared to irrigated radiofrequency ablation (64% versus 63%; relative risk [RR] 0.99, CI 95% 0.85 to 1.15, P=0.87). There were no differences in the procedure time for both methods (mean 146 vs 150 min; weighted mean difference [WMD] -3.24, 95% CI -21.49 to 15.01, P=0.73) and the fluoroscopy time was higher in the cryoballoon group (34 vs 29 min; WMD 5.05, 3.17 to 6.92, P    Conclusions:  The present meta-analysis that includes only randomized data showed similar efficacy and procedure duration for both methods in AF treatment with higher rate of phrenic-nerve injury and fluoroscopy time for cryoballoon ablation.
The lower limit of normal <i>versus</i> a fixed ratio to assess airflow limitation: will the debate ever end?
Authors: Lewis J. Smith
Journal: European Respiratory Journal (2018)

A normal test result is typically differentiated from an abnormal result by identifying those values that fall within (normal) and outside (abnormal) the 95% confidence interval for that test, after the test is evaluated in healthy individuals from the intended population. This approach acknowledges that 5% of a normal population will have an abnormal test result and some individuals with a normal test result will have the disease the test is designed to identify. Such trade-offs are common in the practice of medicine. Identifying airflow limitation using an FEV1/FVC less than 0.70 in a general population of young adults can no longer be justified <http://ow.ly/MRzo30iWja5>
Le pancréas divisum n'est pas à lui seul une cause de pancréatite aiguë récidivante ou chronique
Authors: C Bertin, AL Pelletier, MP Vullierme, F Maire, O Hentic-Dhomé, V Rebours, P Hammel, V Vilgrain, P Ruszniewski, P Lévy
Journal: Endoscopy (2009)

Introduction: Après exclusion des causes »habituelles« de pancréatite aiguë (PA) récidivante ou de pancréatite chronique (PC) (alcool, lithiase biliaire, auto-immunité, génétique, métabolique, etc.), la responsabilité du pancréas divisum (PD) est controversée. L'existence de mutations du gène CFTR constitue un facteur favorisant les PA ou les PC. Certaines observations suggèrent que ces deux facteurs pourraient être associés.
Endoscopic retrograde cholangiopancreatography
Authors: L. Aabakken
Journal: Endoscopy (2012)

The 2012 Digestive Disease Week meeting (DDW; 19 – 22 May, San Diego, California, USA) brought together the finest gastroenterologists from all over the world. A review of the field of endoscopic retrograde cholangiopancreatography (ERCP) showed there to be a good number of research reports, though no groundbreaking novelties. However, solid data were presented, particularly within the fields of cannulation, post-ERCP pancreatitis (PEP), and altered anatomy techniques. In addition, issues of sedation, quality control, and safety were addressed. Selected abstracts from the meeting are reviewed below.
DO PATIENTS REFERRED FOR DIAGNOSTIC GASTROSCOPY FOR IRON DEFICIENCY ANAEMIA HAVE BIOCHEMICAL EVIDENCE OF THIS AND WHAT ARE THEIR OUTCOMES?
Authors: M Patel, K Besherdas
Journal: Endoscopy (2018)

The UK cancer plan aims for a maximum, one-month interval from referral to treatment in suspected malignancy. North London Cancer network enables patients to be reviewed in secondary care within two weeks of referral. This includes iron deficiency anaemia (IDA) – potential indicator of gastric/colonic malignancy. UK guidelines recommend gastroscopy for IDA and if negative for cancer or coeliac disease subsequent colonic investigations.
Abstract P074: Time to First Treatment Modification Among New Statin Users
Authors: James P Burke, Carly J Paoli, Jeffrey McPheeters, Shravanthi R Gandra, Ross J Simpson
Journal: Circulation (2016)

The benefits of lipid lowering therapy (LLT) include reductions in all-cause mortality and fatal CV disease. Studies have shown high rates of LLT discontinuation and poor persistence. This study examined time to treatment modification and types of treatment modifications among patients initiating statin and ezetimibe therapy. This retrospective claims-based study used medical, pharmacy and enrollment data from a large US health plan. Patients had commercial or Medicare Advantage Part D (MAPD) coverage from 1/1/07 to 12/31/12 and were followed for the earlier of 3 years, disenrollment or 12/31/13 (index date= date of first statin and/or ezetimibe use). Treatment modifications included switching, subtraction, dose escalation or reduction, augmentation, reduction, and discontinuation. Patients were assigned to one of three mutually exclusive cohorts: secondary CVD prevention, high risk primary prevention, and primary prevention. Arteriosclerotic cardiovascular disease (ASCVD) was also identified. The first episode of care was defined as the time from the index date to the first treatment modification (episode 1) and subsequent therapy modifications (episodes 2-4) were also examined. The sample included 662,540 patients (mean age 57.4 years, 52.5% male, 19.2% MAPD). Overall mean time to first modification was 341.9 days (SD=333.7; median=200.0). Mean and medians were similar across cohorts but decreased with each subsequent episode of care. Discontinuation at 42.0% (with 70.5% restarting) was the most common treatment modification in the ASCVD cohort followed by switching (10.4%) and statin dose increase (10.3%). The other cohorts followed a similar pattern. Patients remained on their index therapy for a substantial period of time. Surprisingly, there was little difference across risk groups. Initial choice of statin therapy by physician and patient may represent an opportunity to limit unnecessary statin and/or ezetimibe therapy modifications and to improve adherence.
Quel est la prévalence des adénomes transformés au sein des polypes de moins de 10mm de diamètre? Résultats d'une étude mono-centrique prospective
Authors: U Chaput, S Folgado Alberto, V Viallon, F Beuvon, B Terris, R Coriat, M Bensoussan, H Roche, M Gaudric, F Prat, S Chaussade
Journal: Endoscopy (2009)

Introduction: La coloscopie virtuelle est une technique proposée aux Etats-Unis dans le cadre du dépistage du cancer colorectal. Les dernières recommandations américaines préconisent la réalisation d'une coloscopie chez les patients présentant un polype ≥10mm et/ou ≥3 polypes dont un ≥6mm diagnostiqués au colo-scanner. Pour les autres, le choix entre une videocoloscopie et une nouvelle coloscopie virtuelle est laisséà l'appréciation du patient et du médecin. Une étude récente française remet en cause cette attitude puisqu'elle retrouvait 15,6% d'adénomes transformés parmi les adénomes de 6 à 9mm diagnostiqués lors de coloscopies effectuées dans le cadre d'une campagne de dépistage du cancer colorectal. Cette fréquence contraste avec les résultats d'études antérieures retrouvant des chiffres d'adénomes transformés beaucoup moins élevés. L'objectif de ce travail était d'étudier la prévalence des adénomes transformés (dysplasie de haut grade, carcinome in situ ou intra muqueux) parmi les polypes de 0 à 9mm de diamètre.
Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing
Authors: Guangwu Guo, Noopur S. Raje, Charles Seifer, Jake Kloeber, Randi Isenhart, Gavin Ha, Andrew J. Yee, Elizabeth K. O’Donnell, Yu-Tzu Tai, Paul G. Richardson, Giada Bianchi, Jacob P. Laubach, Diane Warren, Erica Gemme, Jordan Voisine, Julia Frede, Antonis Kokkalis, Huiyoung Yun, Valeriya Dimitrova, Tushara Vijaykumar, Matthew Meyerson, Nikhil C. Munshi, Kenneth C. Anderson, Birgit Knoechel, Jens G. Lohr
Journal: Leukemia (2018)
Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies
Authors: Gerit Moser, Sascha Drewlo, Berthold Huppertz, D Randall Armant
Journal: Human Reproduction Update (2018)

Early during human development, the trophoblast lineage differentiates to commence placentation. Where the placenta contacts the uterine decidua, extravillous trophoblast (EVT) cells differentiate and invade maternal tissues. EVT cells, identified by expression of HLA-G, invade into uterine blood vessels (endovascular EVT), as well as glands (endoglandular EVT), and open such luminal structures towards the intervillous space of the placenta. Endoglandular invasion diverts the contents of uterine glands to the intervillous space, while glands near the margin of the placenta that also contain endoglandular EVT cells open into the reproductive tract. Cells of the trophoblast lineage have thus been recovered from the uterine cavity and endocervical canal. An emerging non-invasive technology [trophoblast retrieval and isolation from the cervix (TRIC)] isolates and examines EVT cells residing in the cervix to explore their origin, biology and relationship to pregnancy and fetal status.
Senescent cells: a therapeutic target for cardiovascular disease
Authors: Bennett G. Childs, Hu Li, Jan M. van Deursen
Journal: Journal of Clinical Investigation (2018)

Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging. In the process, senescent cells have attracted attention as a therapeutic target for age-related diseases, including cardiovascular disease (CVD), the leading cause of morbidity and mortality in the elderly. Given the aging global population and the inadequacy of current medical management, attenuating the health care burden of CVD would be transformative to clinical practice. Here, we review the evidence that cellular senescence drives CVD in a bimodal fashion by both priming the aged cardiovascular system for disease and driving established disease forward. Hence, the growing field of senotherapy (neutralizing senescent cells for therapeutic benefit) is poised to contribute to both prevention and treatment of CVD.
DIAGNOSTIC PERFORMANCE OF COLON CAPSULE ENDOSCOPY (CCE2). A PROSPECTIVE MULTICENTER STUDY IN A SCREENING SETTING
Authors: C Spada, C Hassan, M Pennazio, Z Adrián-de-Ganzo, E Rondonotti, E Quintero, S Pecere, N Segnan, G Costamagna, C Senore
Journal: Endoscopy (2018)

To assess CCE-2 diagnostic accuracy in screenees with a positive faecal immunochemical test (FIT) in population based programmes for colorectal cancer (CRC) screening.