tbuckley/cabot-search huggingface dataset:
EWGLI: un programme européen de surveillance de la légionellose associée au voyage
Authors: E. J. Hutchinson, C Joseph, C L R Bartlett
Journal: Eurosurveillance (1996)

Le Groupe de Travail Europeen sur les Infections a Legionella (EWGLI), cree en 1986, a lance en 1997 le Programme Europeen de Surveillance de la Legionellose Associee au Voyage. Les microbiologistes travaillant dans les laboratoires de reference et les epidemiologistes impliques dans les programmes nationaux de surveillance de la legionellose dans les etats membres ont reconnu que les epidemies de legionellose pouvaient etre identifiees a un stade plus precoce grâce a l'echange d'informations. Le programme a pour objectifs prioritaires d'identifier des cas groupes de legionellose pouvant indiquer l'existence d'une source commune d'epidemie, d'alerter rapidement les centres collaborateurs, et de developper une base de donnees europeenne.
Stakeholder Research Priorities for Smoking Cessation Interventions within Lung Cancer Screening Programs. An Official American Thoracic Society Research Statement
Authors: Hasmeena Kathuria, Frank C. Detterbeck, Joelle T. Fathi, Kathleen Fennig, Michael K. Gould, Denise G. Jolicoeur, Stephanie R. Land, Greta M. Massetti, Peter J. Mazzone, Gerard A. Silvestri, Christopher G. Slatore, Robert A. Smith, Anil Vachani, Steven B. Zeliadt, Renda Soylemez Wiener
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Section:ChooseTop of pageAbstract <<ContentsOverviewIntroductionMethodsResultsDiscussionReferencesCITING ARTICLES
Une meilleure surveillance de la tuberculose
Authors: J M Watson
Journal: Eurosurveillance (2000)

En 1996, une declaration de consensus sur la surveillance de la tuberculose en Europe recommandait la collecte de donnees sur tous les cas de tuberculose a un niveau local (1). Cette declaration soutenue par l’Union Internationale contre la Tuberculose et les Maladies Pulmonaires, l’Organisation Mondiale de la Sante et les representants des pays europeens conseillait d’utiliser une serie de donnees standard communes, et de recueillir et analyser des donnees individualisees aux niveaux local et regional/national (1). A la meme epoque, etait mis en place le programme EuroTB, finance par l’Union Europeenne pour le recueil et l’analyse de ces donnees standardisees. Les resultats de cette collaboration ont ete publies (2,3).
System-wide Benefits of Intermeal Fasting by Autophagy
Authors: Nuria Martinez-Lopez, Elena Tarabra, Miriam Toledo, Marina Garcia-Macia, Srabani Sahu, Luisa Coletto, Ana Batista-Gonzalez, Nir Barzilai, Jeffrey E. Pessin, Gary J. Schwartz, Sander Kersten, Rajat Singh
Journal: Cell Metabolism (2017)
TCT-189 High Resolution Imaging by Scanning EM, Reveals An Active Interaction Between Thrombus And Stent Retriever In Patients Treated For Acute Ischemic Stroke
Authors: Hajo Hund, Anouchska Autar, Sharad Ramlal, Daniel Hansen, Geert Lycklama a Nijeholt, Bart Emmer, Aad van der Lugt, Ad van Es, Heleen van Beusekom
Journal: Journal of the American College of Cardiology (2017)
Abstract 18512: Normal Reference Values of Thoracic Aortic Diameter Using Cardiac CT in the Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Sina Rahmani, Dong Li, Song Shou Mao, Yanlin Gao, Rine Nakanishi, Negin Nezarat, Indre Ceponiene, Kazuhiro Osawa, Mitsuru Kanisawa, Matthew Budoff
Journal: Circulation (2016)

Introduction: While growing use of coronary artery calcium scanning by non-contrast cardiac computed tomography (CT) among asymptomatic individuals, normal values of aortic diameters which are rout...
Abstract 17330: A Resting Blood Pressure Greater Than 130/80 mm Hg Correlates With an Increase in Early Structural and Functional Abnormalities: Time to Re-evaluate the Current Standards of Care
Authors: Susan Tucker, Arjun Byju, Mahfouz El Shahawy
Journal: Circulation (2016)

Introduction:  Hypertension is a comorbidity that often leads to cardiovascular events, such as strokes, myocardial infarctions, and kidney disease. Current data suggests that hypertension needs to be treated only when the values exceed 140/90 mm Hg.   Hypothesis:  To re-evaluate the current recommendations for treatment of hypertension as a preventative measure, to reduce the risk of functional and structural abnormalities in untreated, asymptomatic subjects as assessed by the Early CVD Risk Score (ECVDRS), also known as the Rasmussen Risk Score (RRS).   Methods:  A total of 2490 subjects, ages 15-101, were screened for early indicators of cardiovascular disease using the RRS, which consists of a panel of 10 tests; large (C1) and small (C2) artery stiffness, resting BP and post mild exercise, CIMT, abdominal aorta and left ventricle ultrasounds, retinal photography, microalbumuria, ECG, and pro-BNP. 2143 of the subjects were untreated and asymptomatic. The untreated and asymptomatic subjects were then separated based on their resting systolic and diastolic blood pressures and further evaluated for early indicators of CVD risk based on their RRS.   Results:  The subjects whose resting blood pressure was greater than 130/80 mm Hg revealed a significant increase in their overall RRS, over those subjects whose resting blood pressure was equal to or less than 130/80 mm Hg. Significant changes were identified in the overall RRS, abnormal rise in blood pressure, C2, CIMT, and microalbumuria as displayed in Figure 1.   Conclusions:  The risk of CVD was significantly increased in subjects whose resting blood pressure was greater than 130/80 mm Hg. Current standards of care need to be re-evaluated in order to better prevent future CVD. An ounce of early cardiovascular prevention is worth more than pounds of late cure.
Reti internazionali di sorveglianza e principi di collaborazione
Authors: I. S.T. Fisher, O N Gill
Journal: Eurosurveillance (2001)

Nonostante il moltiplicarsi e il perfezionarsi delle reti internazionali di sorveglianza sulle malattie infettive, sorgono molte domande sulla trasmissione dei dati personali e delle informazioni. La natura confidenziale dei dati condivisi e la loro diffusione internazionale all'interno e all'esterno della rete sono quindi potenziali fonti di conflitto. Per risolvere questi problemi, Enter-net ha elaborato i suoi Principi di collaborazione, destinati a tutti i partecipanti alla rete e a tutti gli altri potenzialmente coinvolti. Questi principi propongono soluzioni alle domande relative all'accesso ai database creati all'interno della struttura della rete, alla qualita e alla confidenzialita dei dati circolanti, alla responsabilita individuale nell'identificazione del prodotto incriminato in caso di un focolaio epidemico, e anche alla trasmissione dell'informazione all'esterno della rete. Questi principi, che devono essere rivisti regolarmente, hanno come primo scopo quello di ottimizzare la scoperta tempestiva e la gestione di epidemie di origine alimentare, e a prendere le necessarie misure di salute pubblica. Considerando la natura del problema, tuttavia, alcuni di questi principi riguardano anche altre reti di sorveglianza.
MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity <i>via</i> Direct Binding to the STAT3 DNA-Binding Domain
Authors: Dong Ju Son, Jie Zheng, Yu Yeon Jung, Chul Ju Hwang, Hee Pom Lee, Ju Rang Woo, Song Yi Baek, Young Wan Ham, Min Woong Kang, Minho Shong, Gi Ryang Kweon, Min Jong Song, Jae Kyung Jung, Sang-Bae Han, Bo Yeon Kim, Do Young Yoon, Bu Young Choi, Jin Tae Hong
Journal: Theranostics (2017)

Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing small-molecule inhibitors that target the SH2 domain of STAT3 remains the leading focus for drug discovery, there has been a growing interest in targeting the DNA-binding domain (DBD) of the protein. Methods: We demonstrated the potential antitumor activity of a novel, small-molecule (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol (MMPP) that directly binds to the DBD of STAT3, in patient-derived non-small cell lung cancer (NSCLC) xenograft model as well as in NCI-H460 cell xenograft model in nude mice. Results: MMPP effectively inhibited the phosphorylation of STAT3 and its DNA binding activity in vitro and in vivo. It induced G1-phase cell cycle arrest and apoptosis through the regulation of cell cycle- and apoptosis-regulating genes by directly binding to the hydroxyl residue of threonine 456 in the DBD of STAT3. Furthermore, MMPP showed a similar or better antitumor activity than that of docetaxel or cisplatin. Conclusion: MMPP is suggested to be a potential candidate for further development as an anticancer drug that targets the DBD of STAT3.
Epidemiologia da rubéola na Finlândia
Authors: I Davidkin, H Peltola, P Leinikki
Journal: Eurosurveillance (2004)

Antes de se terem iniciado os programas de vacinacao contra a rubeola, a infeccao da rubeola era prevalente nas criancas finlandesas. A doenca ocorria sob a forma de epidemias a intervalos de alguns anos. A infeccao da rubeola era frequentemente contraida entre os 2 e os 12 anos de idade. As vacinacoes especificamente destinadas a erradicar a rubeola foram iniciadas com a vacina monovalente em meados dos anos setenta, e o programa de vacinacao contra o sarampo, papeira e rubeola (MMR) com duas injeccoes foi instituido em 1982. Alguns anos depois do lancamento do programa MMR tornou-se evidente uma reducao inequivoca dos casos de rubeola. Gracas a uma cobertura de vacinacao suficientemente elevada (g 95% desde 1987), a circulacao do virus da rubeola indigeno na populacao finlandesa cessou no final dos anos noventa. Desde a sua eliminacao que foram importados para a Finlândia alguns casos de rubeola, mas estes nao deram origem a qualquer caso secundario. Tal mostra inequivocamente que a protecao contra a rubeola continua a ser eficaz, embora os nossos estudos de coorte sugiram que os niveis de anticorpos induzidos pela vacina diminuam no decurso do tempo. O programa MMR tambem eliminou o sindrome de rubeola congenita (CRS) do pais. O ultimo caso de CRS foi registado em 1986. Em consequencia da elevada cobertura do programa de vacinacao com duas doses de MMR, a rubeola foi eliminada com sucesso da Finlândia. Continua por esclarecer quanto tempo ira durar a proteccao adquirida.
P-MartCancer–Interactive Online Software to Enable Analysis of Shotgun Cancer Proteomic Datasets
Authors: Bobbie-Jo M. Webb-Robertson, Lisa M. Bramer, Jeffrey L. Jensen, Markus A. Kobold, Kelly G. Stratton, Amanda M. White, Karin D. Rodland
Journal: Cancer Research (2017)

P-MartCancer is an interactive web-based software environment that enables statistical analyses of peptide or protein data, quantitated from mass spectrometry-based global proteomics experiments, without requiring in-depth knowledge of statistical programming. P-MartCancer offers a series of statistical modules associated with quality assessment, peptide and protein statistics, protein quantification, and exploratory data analyses driven by the user via customized workflows and interactive visualization. Currently, P-MartCancer offers access and the capability to analyze multiple cancer proteomic datasets generated through the Clinical Proteomics Tumor Analysis Consortium at the peptide, gene, and protein levels. P-MartCancer is deployed as a web service (https://pmart.labworks.org/cptac.html), alternatively available via Docker Hub (https://hub.docker.com/r/pnnl/pmart-web/).
TCT-58 Biomechanics and Drug Elution in Arterial Response to Peripheral Stents: A Comparative Study of 3 Contemporary Stents in Balloon-Predilated Femoral Arteries of Familial Hypercholesterolemic Swine
Authors: Yanping Cheng, Jenn McGregor, Gerard Conditt, Miguel Montero-Baker, Greg Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2017)
When targets miss the mark
Authors: Richard Hurley
Journal: BMJ (2017)

Warnings of a looming winter crisis in the NHS are coming thicker and faster, with another just last week (doi:10.1136/bmj.j4885). It’s appropriate, then, that our latest Head to Head debate considers emergency care, a barometer of NHS performance in the cold season, and whether the “four hour wait” target has had its day.

Since 2004 this target has stipulated that emergency departments in England should see, treat, and admit or discharge most patients within that time.

“Before the target was introduced, being a …
The Lancet Commission on pollution and health
Authors: Philip J Landrigan, Richard Fuller, Nereus J R Acosta, Olusoji Adeyi, Robert Arnold, Niladri (Nil) Basu, Abdoulaye Bibi Baldé, Roberto Bertollini, Stephan Bose-O'Reilly, Jo Ivey Boufford, Patrick N Breysse, Thomas Chiles, Chulabhorn Mahidol, Awa M Coll-Seck, Maureen L Cropper, Julius Fobil, Valentin Fuster, Michael Greenstone, Andy Haines, David Hanrahan, David Hunter, Mukesh Khare, Alan Krupnick, Bruce Lanphear, Bindu Lohani, Keith Martin, Karen V Mathiasen, Maureen A McTeer, Christopher J L Murray, Johanita D Ndahimananjara, Frederica Perera, Janez Potočnik, Alexander S Preker, Jairam Ramesh, Johan Rockström, Carlos Salinas, Leona D Samson, Karti Sandilya, Peter D Sly, Kirk R Smith, Achim Steiner, Richard B Stewart, William A Suk, Onno C P van Schayck, Gautam N Yadama, Kandeh Yumkella, Ma Zhong
Journal: The Lancet (2017)
Abstract 10467: Inflammation may be Involved in Ischemic Preconditioning in Rat Model of CPR
Authors: Shen Zhao, Jiangang Wang, Lu Yin, Ziren Tang, Peng Sun, Jena Kline, Xiaobo Wu, Wanchun Tang
Journal: Circulation (2015)

Background: Ischemia preconditioning (IPC) is a potent strategy that minimizes post-resuscitation cardiac and neurological dysfunction via a K ATP channel-dependent mechanism. Inhibition of inflammation is also related to ischemic tolerance. In this study, we investigate the relation between the two intrinsic mechanisms in a rat model of cardiac arrest and CPR. Hypothesis: Activation of K ATP channels and anti-inflammatory response are two independent mechanisms of IPC to improve post-CPR myocardial and cerebral function. Methods: A total of 24 Sprague-Dawley rats (450-550g) were randomized into three groups (n=8 for each group): 1) control, 8 minutes of untreated ventricular fibrillation (VF) followed by 8 minutes of cardiopulmonary resuscitation and defibrillation; 2) IPC, remote IPC initiated 55 minutes before the induction of VF; 3) IPC+GLIB, glibenclamide (0.3 mg/kg, i.v.) was administered 45 minutes before remote IPC, and rest of protocol was the same as the IPC group. Doppler echocardiography, neurologic deficit score (NDS) scale, and the duration of survival were monitored in all animals. The level of NF-κB, IL-1β, IL-10 were evaluated using the enzyme-linked immunosorbent assay (ELISA). Results: Compared with the control groups, significantly greater CO and EF, lower MPI, improved NDS, and increased duration of survival were observed in both the IPC and IPC+GLIB group during post-resuscitation ( p &lt; 0.05 or 0.01 versus control group). Glibenclamide partly reversed the improvement induced by ischemic preconditioning ( p &lt; 0.05 or 0.01 versus IPC group) (Fig. 1). However, there were no significant differences in biomarkers between the IPC and IPC+GLIB group (Fig. 2). Conclusions: In a rat cardiac arrest model, anti-inflammatory response attenuated the myocardial and neurological dysfunction during the post-resuscitation via a non-K ATP channel-dependent mechanism.
Mainstreaming Latent Tuberculosis Infection Testing and Treatment in the United States
Authors: Jennifer Flood, Pennan M. Barry
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
A nonimmune function of T cells in promoting lung tumor progression
Authors: Jesse A. Green, Nicholas Arpaia, Michail Schizas, Anton Dobrin, Alexander Y. Rudensky
Journal: The Journal of Experimental Medicine (2017)

The involvement of effector T cells and regulatory T (T reg) cells in opposing and promoting solid organ carcinogenesis, respectively, is viewed as a shifting balance between a breach versus establishment of tolerance to tumor or self-antigens. We considered that tumor-associated T cells might promote malignancy via distinct mechanisms used by T cells in nonlymphoid organs to assist in their maintenance upon injury or stress. Recent studies suggest that T reg cells can participate in tissue repair in a manner separable from their immunosuppressive capacity. Using transplantable models of lung tumors in mice, we found that amphiregulin, a member of the epidermal growth factor family, was prominently up-regulated in intratumoral T reg cells. Furthermore, T cell-restricted amphiregulin deficiency resulted in markedly delayed lung tumor progression. This observed deterrence in tumor progression was not associated with detectable changes in T cell immune responsiveness or T reg and effector T cell numbers. These observations suggest a novel "nonimmune" modality for intratumoral T reg and effector T cells in promoting tumor growth through the production of factors normally involved in tissue repair and maintenance.
TCT-551 Lactate Clearance is a Prognostic Marker for Survival in Cardiogenic Shock Receiving Early Percutaneous Mechanical Circulatory Support
Authors: Shailendra Singh, Yonathan Litwok, Evelina Grayver, Perwaiz Meraj, Alexander Lee, Cindy Grines
Journal: Journal of the American College of Cardiology (2017)
Early Prosthetic Valve Dysfunction Due to Bioprosthetic Valve Thrombosis
Authors: Alexander Egbe, Sorin V. Pislaru, Mahmoud A. Ali, Arooj R. Khan, Amber N. Boler, Hartzell V. Schaff, Emmanuel Akintoye, Heidi M. Connolly, Vuyisile T. Nkomo, Patricia A. Pellikka
Journal: JACC. Cardiovascular imaging (2017)
Inspiring excellence in musculoskeletal sports medicine
Authors: Nikolaos Malliaropoulos, Mourad Ghrairi, Moustafa Al Hashimi, Yacine Zerguini, Nat Padhiar
Journal: British Journal of Sports Medicine (2017)

Musculoskeletal sports medicine is one of the main components of sport and exercise medicine (SEM), and injury prevention is a challenge for everyone involved in sport — sports physicians, athletes, coaches, clubs and all the other support staff. In this issue, we have brought together the latest research in injury prevention and musculoskeletal SEM.

ACL injuries are still a major challenge in everyday clinical practice. Evidence-based recommendations for surgical intervention, as opposed to conservative management, has not been clearly established yet. This study ( see page 1622 ) provides the basis for clinicians to offer individualised management options, conservative or surgical, tailored to the …
Abstract 18272: Differential Effects of Carvedilol and Atenolol on Acetylcholine-Activated K+ Current ; Possible Atrial-Specific Antiarrhythmic Effects of Carvedilol on Atrial Fibrillation
Authors: Tae-joon Cha, Eun Kyoung Choi, Ga-In Yu, Bong Joon Kim, Dong Hyeon Park
Journal: Circulation (2016)

Recently, the upregulation of  I  KACh  and muscarinic receptor expression has been reported in atrial fibrillation (AF) patients and in AF induced experimentally in dogs. Therefore blockage of  I  KACh  could terminate AF induced by increased vagal tone. Blockade of atrial-specific K +  channels could provide an approach for the treatment of atrial arrhythmia without adverse ventricular effects. Randomized trials have demonstrated that β blockers have beneficial long-term effects on mortality and morbidity in patients with heart failure. However, not all β blockers have identical effects, and the use of various β blockers in AF has yet to be thoroughly evaluated. Therefore, we examined the effects of carvedilol and atenolol on acetylcholine-activated K +  channels in mouse atrial cardiomyocytes.   Methods:  In the present study,  I  KACh  current was recorded using a nystatin-perforated whole cell patch-clamp technique. Mouse atrial cardiomyocytes were voltage clamped at -40 mV, and  I  KACh  was activated by extracellular application of acetylcholine. After the baseline  I  KACh  current was measured, varying concentrations of β blockers were applied for 5 minutes, and a second  I  KACh  current was recorded. Action potential duration (APD) and current-voltage curves were recorded from isolated cardiomyocytes.   Results:  The application of acetylcholine (10 μM) to the bath solution activated  I  KACh  in cardiomyocytes. Carvedilol inhibited  I  KACh  in a dose-dependent manner between 0.1 and 5 μM. The concentration required for half-maximal inhibition (IC 50 ) was 1.03 μM for the peak and 1.04 μM for the quasi-steady-state. In addition, carvedilol attenuated acetylcholine-induced APD shortening. We next investigated the effects of atenolol on  I  KACh  using the same experimental protocol. Addition of atenolol to the bath solution did not alter the peak amplitude or quasi-steady-state of the  I  KACh  currents compared to controls.   Conclusion:  We found that the β blocker carvedilol suppressed acetylcholine-activated potassium current, while another β blocker, atenolol, did not. Blockade of atrial K +  channels by carvedilol provides another potential option for the treatment of AF. These findings suggest that carvedilol may be used in AF as an atrial-specific antiarrhythmic agent.
Situación francesa respecto a la variante sueca de Chlamydia trachomatis
Authors: B de Barbeyrac, S Raherison, S Cado, F Normandin, M Clerc, V Clairet, V Goulet, C Bébéar
Journal: Eurosurveillance (2007)

En 2006 se identifico en Suecia una cepa mutante de Chlamydia trachomatis con una delecion en el plasmido que no puede detectarse con las pruebas del mercado que buscan la zona suprimida. Para poder estudiar la diseminacion de esta cepa en Francia, el Centro de Referencia Nacional para Clamidias y el Institut de Veille Sanitaire organizaron un sistema de vigilancia basado en laboratorios.