tbuckley/cabot-search huggingface dataset:
PUB005 CT Findings Reduce the Risk of EBUS-TBNA
Authors: K. Kambara, R. Hayashi, Z. Setou, T. Hirai, K. Shimokawa, K. Tokui, C. Taka, S. Okazawa, M. Inomata, S. Imanishi, T. Yamada, T. Miwa, S. Matui, K. Tobe, Y. Akemoto, N. Kitamura, T. Homma
Journal: Journal of Thoracic Oncology (2017)
P3.01-052 The Prevalence and Genotype Distribution of Dual in Cis EGFR Mutations in Chinese Advanced Non-Small Cell Lung Cancer Patients
Authors: M. Li, C. Zhou, J.-. Yang, S. Lu, D. Zheng, J. Hu, H. Zeng, Y. Lu, K. Lu, X. Mao, H. Zhang, N. Zhang, C. Hu
Journal: Journal of Thoracic Oncology (2017)
Eficacia de la vacuna contra la gripe durante un brote de influenza A en una residencia para la tercera edad de la región de los Pirineos Atlánticos, Francia, noviembre - diciembre 1995
Authors: A Infuso, S Baron, H Fauveau, M Melon, H Fleury, J C Desenclos
Journal: Eurosurveillance (1996)

El 4 de diciembre de 1995, un funcionario sanitario de la 'Direction Departementale de l'Action Sanitaire et Sociale des Pyrenees Atlantiques' de Francia, recibio notificacion acerca de un brote de enfermedad respiratoria aguda entre los ocupantes de una residencia para la tercera edad. Mas de 50 de los 69 ocupantes habian estado enfermos durante las tres semanas anteriores y a seis se les habia ingresado en el hospital. Se llevo a cabo una investigacion epidemiologica y microbiologica para identificar la causa del brote y factores de riesgo asociados, asi como para medir la eficacia de la vacuna (EV).
ARIEL4: An international, randomised phase 3 study of rucaparib vs chemotherapy as treatment for BRCA1- or BRCA2-mutated, relapsed ovarian cancer
Authors: D. Lorusso, C. Nicoletta, P. Sandro, S. Roberto, S. Paolo, Z. Claudio, M.O. Amit, O. Ana, S. Tamar, M.S. Elizabeth, M.B. Igor, H. Tomasz, K. Jaroslav, M. Vladimir, P. Róbert, S.V. Luciana, T. Chris, U. Caro, D. Adam, S.K. Rebecca
Journal: Annals of Oncology (2017)
Genetic and Immune Profiles of Solid Predominant Lung Adenocarcinoma Reveal Potential Immunotherapeutic Strategies
Authors: Zhong-Yi Dong, Chao Zhang, Yu-Fa Li, Jian Su, Zhi Xie, Si-Yang Liu, Li-Xu Yan, Zhi-Hong Chen, Xue-Ning Yang, Jun-Tao Lin, Hai-Yan Tu, Jin-Ji Yang, Qing Zhou, Yue-Li Sun, Wen-Zhao Zhong, Yi-Long Wu
Journal: Journal of Thoracic Oncology (2017)
EXTH-04. GUIDING PRINCIPLES FOR PREDICTING THE DISTRIBUTION OF TUMOR TREATING FIELDS IN A HUMAN BRAIN: A COMPUTER MODELING STUDY INVESTIGATING THE IMPACT OF TUMOR POSITION, CONDUCTIVITY DISTRIBUTION AND TISSUE HOMOGENEITY
Authors: Anders Rosendal Korshoej, Frederik Lundgaard Hansen, Nikola Mikic, Axel Thielscher, Gorm Burckhardt von Oettingen, Jens Christian Hedemann Sørensen
Journal: Neuro-Oncology (2017)

Tumor treating fields (TTFields) are increasingly used as a fourth modality in glioblastoma therapy. TTFields are alternating electrical fields, which inhibit cancer growth by disrupting mitotic processes. Optimization of TTFields efficacy requires thorough understanding of distribution of TTFields “dose” in the brain. Here we provide simple guiding principles, which facilitate intuitive understanding of such distributions and the impact of the technology. Our results are based on extensive electrical field modeling. We estimated TTFields distribution in a realistic human head model using finite element methods. We introduced twenty-four virtual tumors, which were systematically placed at different positions relative to the active transducer-arrays. We found that the TTFields distribution is largely determined by local differences in tissue conductivity. The cerebrospinal fluid creates high-conductivity pathways, which causes currents to flow through the sulci, ventricles and resection cavities towards deeper regions. Correspondingly, local field “hot spots” occurred in deeply seated tumors embedded in white matter, in tumors close to the sulcal fundi and at regions around the resection border. Field strengths were not higher for tumors close to the active arrays. The left/right array configuration was superior to the anterior/posterior configuration, regardless of the tumor position. High conducting glioma-tissue creates a preferred pathway for current flow, which causes focal enhancement of the field near boundaries between the tumor and surrounding tissue that are perpendicular to the applied field. This effect was even more pronounced for tumors with high conductive central necrosis. Necrosis further caused a significant non-uniformity of the induced field within the tumor. The presented results provide guiding principles to understand the distribution of TTFields. This may potentially be used for a variety of applications, including prediction local risk and site of recurrence. However, studies examining the connection between field distribution and site of recurrence need to be conducted.
OA 12.03 Clinical Features of Advanced Lung Cancer Harboring HER2 Aberrations: A Large Prospective Cohort Study (HER2-CS STUDY)
Authors: S. Hosokawa, A. Bessho, K. Ninomiya, T. Tanaka, N. Ishikawa, M. Yamasaki, T. Shibayama, K. Aoe, T. Kozuki, N. Fujimoto, K. Gemba, Y. Ueda, M. Inoue, T. Murakami, S. Kuyama, H. Kawai, K. Fujitaka, K. Inoue, M. Takata, H. Yanai, K. Hotta, K. Kiura
Journal: Journal of Thoracic Oncology (2017)
Epidémie de Salmonella Enteritidis lysotype 21 en Autriche, 2005
Authors: D Schmid, S Schandl, A M Pichler, C. Kornschober, C Berghold, A Beranek, G Neubauer, M Neuhold-Wassermann, W Schwender, A Klauber, A Deutz, P Pless, F Allerberger
Journal: Eurosurveillance (2006)

L’article suivant decrit une epidemie de gastroenterite due a Salmonella Enteritidis PT 21 associee a la participation, le 4 mai 2005, a la fete annuelle traditionnelle d’un petit village d’Autriche. L’epidemie a dure du 4 au 8 mai. Des investigations epidemiologiques descriptive et analytique ont ete conduites pour determiner l’etendue de l’epidemie et identifier les facteurs de risque. Quatre-vingt-cinq personnes sur les 115 ayant participe a la fete repondaient au critere d’un cas epidemique (taux d’attaque=73,9%). Une recherche de salmonella a ete realisee sur les echantillons de selles de 52 patients, dont deux membres du personnel des cuisines. Salmonella Enteritidis PT 21 etait present dans 20 echantillons. L’etude de cohorte a montre que la cause probable de l’epidemie etait la salade mixte, contenant des pommes de terre (RR: 10.4, 95%CI 2.8 – 39.1; P=l0.001). L’agent responsable de l’epidemie a ete isole par culture dans les œufs provenant du stock utilise pour la fete, dans les trois ecouvillons utilises pour les echantillons de selles, et dans l’echantillon de poussiere preleve dans le poulailler des poules pondeuses d’ou provenaient les œufs incrimines. Le sous-typage moleculaire par electrophorese en champ pulse de l’ADN genomique apres digestion par XbaI a montre que les isolats provenant des œufs, des cas, et de l’elevage etaient indiscernables. L’hypothese retenue est la survenue d’une contamination croisee entre les œufs et les pommes de terre cuites, dans la cuisine lors de la manipulation des œufs crus par les habitants du village au cours de la preparation d’une sauce traditionnelle viennoise. La proliferation bacterienne a pu etre facilitee par le fait que les pommes de terre pelees n’ont pas ete gardees au froid. Les œufs provenant de petits elevages avicoles, conserves de maniere « naturelle » traditionnelle ne devraient pas etre consideres comme indemnes de salmonelles.
The β and α2δ auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for TH2 lymphocyte function and acute allergic airway inflammation
Authors: Nicolas Rosa, Emily Triffaux, Virginie Robert, Marion Mars, Martin Klein, Gregory Bouchaud, Astrid Canivet, Antoine Magnan, Jean-Charles Guéry, Lucette Pelletier, Magali Savignac
Journal: Journal of Allergy and Clinical Immunology (2017)
Staphylococcus aureus resistentes a la meticilina productores de leucocidina de Panton-Valentine (PVL-SARM ): situación en los Paises Bajos en 2003
Authors: W J B Wannet, M E Heck, G N Pluister, E Spalburg, M G Van Santen, X W Huijsdans, E Tiemersma, A J de Neeling
Journal: Eurosurveillance (2004)

En los Paises Bajos en 2003, el analisis de los aislamientos de Staphylococcus aureus resistentes a la meticilina (SARM) ha revelado que el 8% de los aislamientos procedentes de hospitales llevaban genes para la leucocidina de Panton-Valentine (PVL). El subtipaje molecular mostro que la mayoria de los genotipos de PVL- SARM holandeses correspondian a tipos epidemicos globales bien conocidos. Las secuencias mas frecuentes eran de tipo ST8, ST22, ST30, ST59 y ST80. En los Paises Bajos, los SARM aumentaron del 1% en 2002 al 17% en 2003. Es importante senalar que la emergencia de los PVL- SARM esta afectando no solamente a la comunidad, sino tambien a los hospitales.
MA 09.02 Ultra-Central Tumors Treated with Stereotactic Body Radiotherapy: A Single Institutional Experience
Authors: V. Yau, S. Raman, S. Pineda, L. Le, A. Lau, A. Bezjak, J. Cho, A. Sun, A. Hope, M. Giuliani
Journal: Journal of Thoracic Oncology (2017)
OA 02.02 Ipilimumab and Nivolumab in the Treatment of Recurrent Malignant Pleural Mesothelioma: A Phase II Study
Authors: M. Disselhorst, E. Harms, H. Van Tinteren, J. Quispel-Janssen, K. Monkhorst, S. Burgers, P. Baas
Journal: Journal of Thoracic Oncology (2017)
EPID-18. NOONAN SYNDROME CAN BE ASSOCIATED WITH HIGH GRADE GLIOMA; A REPORT OF TWO CASES
Authors: Moatasem El-Ayadi, Marc Ansari, Caspar Kühnöl, Anne Bendel, Dominik Sturm, Torsten Pietsch, Christof Kramm, André von Bueren
Journal: Neuro-Oncology (2017)

Noonan syndrome (NS), an autosomal dominant disorder, is characterized by short stature, congenital heart defects, developmental delay, and facial dysmorphism. PTPN11 germline mutations are the most common cause of NS. Patients with NS are at an increased risk of developing hematologic malignancies and solid tumors, including brain tumors. Commonly associated brain tumors are dysembryoplastic neuroepithelial tumor (DNET) and low-grade astrocytoma. Here we report two cases of anaplastic astrocytoma (AA) with PTPN11-related NS. These are, to the best of our knowledge, the only two high grade glioma (HGG) cases with NS reported in the literature. The first case is a 14-year-old girl presenting with headaches, head tilt, and ataxia. MRI demonstrated a heterogeneously enhancing mass arising from the left brainstem/cerebellar peduncle. The tumor was near completely resected and pathology was consistent with a HGG. Due to short stature and mild dysmorphism, she underwent PTPN11 mutational germline analysis revealing a heterozygous c.922 A>G (p.Asn308Asp) PTPN11 mutation consistent with NS. The second case is a 9-year-old male presenting with a history of repeated vomiting and headaches. MRI showed multifocal disease involving the 3rd ventricle, cerebellum and fornix, thus only subtotal surgical resection was feasible and pathology revealed AA. Molecular analysis indicated amplification of CDK4 and MDM2 with loss of CDKN2A/B as well as an FGFR1 hotspot mutation. The DNA methylation profile was consistent with anaplastic pilocytic astrocytoma. The patient had dysmorphic features with hypertelorism and mental retardation. Mutational germline analysis showed PTPN11 heterozygous mutation c.5C>T (p.Thr2IIe). Both cases were centrally reviewed (T.P.) and neuropathological diagnosis of anaplastic astrocytoma, IDH wild-type was confirmed. Systematic review of literature identified 24 cases of brain tumors associates with NS, all of which were low-grade glial or glioneuronal tumors except for one case of medulloblastoma. Our report points out possible association of NS with HGG.
P3.03-005 Inhibition of PRMT5 is Synthetic Lethal in Mesotheliomas Harboring MTAP Loss
Authors: Annabel Sharkey, Luke Martinson, John Le Quesne, David Moore, Apostolos Nakas, Phillip Quirke, Morag Taylor, Sara Tenconi, Gareth Wilson, David Waller, Charles Swanton, Sara Busacca, Dean Fennell
Journal: Journal of Thoracic Oncology (2017)
P1.17-008 Clinical and Oncological Outcomes on Resected Thymomas over a Decade at the National Cancer Institute at Mexico City
Authors: R. López Saucedo, E. Jiménez Fuentes, J. De La Garza, O. Arrieta, M. Moscoso Fernández Salvador, J. González Luna, F. Corona Cruz
Journal: Journal of Thoracic Oncology (2017)
p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia
Authors: Sarah P. Short, Jumpei Kondo, Whitney G. Smalley-Freed, Haruna Takeda, Michael R. Dohn, Anne E. Powell, Robert H. Carnahan, Mary K. Washington, Manish Tripathi, D. Michael Payne, Nancy A. Jenkins, Neal G. Copeland, Robert J. Coffey, Albert B. Reynolds
Journal: Journal of Clinical Investigation (2017)

p120-Catenin (p120) functions as a tumor suppressor in intestinal cancer, but the mechanism is unclear. Here, using conditional p120 knockout in Apc-sensitized mouse models of intestinal cancer, we have identified p120 as an “obligatory” haploinsufficient tumor suppressor. Whereas monoallelic loss of p120 was associated with a significant increase in tumor multiplicity, loss of both alleles was never observed in tumors from these mice. Moreover, forced ablation of the second allele did not further enhance tumorigenesis, but instead induced synthetic lethality in combination with Apc loss of heterozygosity. In tumor-derived organoid cultures, elimination of both p120 alleles resulted in caspase-3–dependent apoptosis that was blocked by inhibition of Rho kinase (ROCK). With ROCK inhibition, however, p120-ablated organoids exhibited a branching phenotype and a substantial increase in cell proliferation. Access to data from Sleeping Beauty mutagenesis screens afforded an opportunity to directly assess the tumorigenic impact of p120 haploinsufficiency relative to other candidate drivers. Remarkably, p120 ranked third among the 919 drivers identified. Cofactors α-catenin and epithelial cadherin (E-cadherin) were also among the highest scoring candidates, indicating a mechanism at the level of the intact complex that may play an important role at very early stages of of intestinal tumorigenesis while simultaneously restricting outright loss via synthetic lethality.
ACTR-10. PATTERNS OF TTFIELDS-RELATED SEVERE SKIN TOXICITY IN GBM PATIENTS
Authors: Frank Lieberman, Chae-Yong Kim, Holger Hirte, Fabio Iwamoto, Alessandro Olivi
Journal: Neuro-Oncology (2017)

Tumor Treating Fields (TTFields) are a medical device-based anti-mitotic therapy, which has demonstrated significant survival superiority when combined with maintenance temozolomide in a phase III trial in newly-diagnosed glioblastoma. Local dermatitis underneath the arrays is the only frequent TTFields-related adverse event (AE), and is reported in around 50% of all patients treated with TTFields across different cancers. Only 1–3% of these patients have a high grade severity of this AE. TTFields-related dermatitis is assumed to be primarily caused by the continuous exposure of the skin to array components (Lacouture ME, et al., 2014). We analyzed patterns related to the appearance of severe skin toxicity in the seven newly-diagnosed GBM patients reported to have this adverse event on the EF-14 trial. A total of 466 patients received TTFields on the EF-14 study, out of which 242 (52%) were reported to have dermatitis. Biopsy only patients had lower incidence of the AE as did patients who used the device for less hours a day, but other patient characteristics were balanced between TTFields-treated patients with or without dermatitis. In patients who had severe skin toxicity, the median time from the initiation of TTFields to the first diagnosis of any TTFields-related skin toxicity was 18.5 days (range: 11–89 days). The following TTFields-related skin toxicities were reported: Rash, irritation, erythema, pruritus, contact dermatitis, ulceration, infection and skin breakdown. All patients had low-grade skin toxicity (CTCAE grade 1–2) prior to presenting with grade 3 toxicity. No grade 4 (life-threatening) event was reported. The median duration of severe skin toxicity was 17 days (range: 2–61 days), and all of them resolved without sequelae. These results indicate that severe skin toxicity is always preceded by lower grade skin toxicity, suggesting that proper identification and treatment of low grade dermatitis may prevent severe skin toxicity related to TTFields.
P3.16-048 The Role of Pulmonary Resection in Stage IVa Non-Small Cell Carcinoma Patients
Authors: T. Igarashi, K. Hayashi, K. Okamoto, R. Kaku, Y. Kataoka, Y. Kawaguchi, M. Hashimoto, Y. Ohshio, K. Teramoto, J. Hanaoka
Journal: Journal of Thoracic Oncology (2017)
Prognostic impact of CA15-3 pre-treatment levels in ovarian cancer patients
Authors: E. Maccaroni, R. Giampieri, M. Del Prete, G. Principi, R. Bracci, A. Calcinari, A. Della Mora, F. Bianchi, L. Belvederesi, C. Brugiati, S. Pagliaretta, M. Pistelli, A. Savini, A. Pagliacci, Z. Ballatore, F. Bini, M.G. Baleani, L. Cantini, A. Murrone, R. Berardi
Journal: Annals of Oncology (2017)
Objective outcome measures: Collecting meaningful data on alopecia areata
Authors: Elise A. Olsen, Janet Roberts, Leonard Sperling, Antonella Tosti, Jerry Shapiro, Amy McMichael, Wilma Bergfeld, Valerie Callender, Paradi Mirmirani, Ken Washenik, David Whiting, George Cotsarelis, Maria Hordinsky
Journal: Journal of the American Academy of Dermatology (2017)
Carne bovina macinata e salmonellosi umana: sintesi delle indagini su tre epidemie in Francia
Authors: S Haeghebaert, L Duché, C Gilles, B Masini, M Dubreuil, J C Minet, P Bouvet, F Grimont, E Delarocque Astagneau, V Vaillant
Journal: Eurosurveillance (2001)

Dalla sintesi delle indagini su tre epidemie di salmonellosi avvenute in Francia tra il 1998 e il 2000 si conferma il ruolo del consumo di carne bovina macinata e si sottolinea l'importanza delle misure preventive
P1.02-033 Differentiating of Cytomorphological Characteristics in Non-Small Cell Lung Cancer Predicts Value of Radiologic Features
Authors: R. Tanaka, M. Fujiwara, K. Tachibana, J. Miura, R. Shimizu, Y. Nagashima, T. Miya, H. Takei, J. Shibahara, H. Kamma, H. Kondo
Journal: Journal of Thoracic Oncology (2017)
TRANSMISSION OF PROTEIN HYPERSENSITIVENESS FROM MOTHER TO OFFSPRING
Journal: JAMA (1928)

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Monitoring metastatic breast cancer (M-MBC) during treatment: a GIM (Gruppo Italiano Mammella) survey
Authors: M. Bonotto, D. Basile, L. Gerratana, G. Pelizzari, M. Bartoletti, M.G. Vitale, V. Fanotto, C. Lisanti, C. Bozza, M. Cinausero, C. Andreetta, S. Russo, M. Mansutti, A.M. Minisini, L. Merlini, M. De Laurentiis, F. Montemurro, G. Fasola, L. Del Mastro, F. Puglisi
Journal: Annals of Oncology (2017)
MA 05.04 Distinct Immunosuppressive Microenvironment Determines Poor Prognosis of Nonsmokers with Adenocarcinoma of Non-Small Cell Lung Cancer
Authors: T. Kinoshita, T. Fujita, Y. Hayashi, T. Ohtsuka, T. Mitsudomi, H. Asamura, K. Yasufuku, Y. Kawakami
Journal: Journal of Thoracic Oncology (2017)
Agrupaciones de casos de legionelosis en Francia, septiembre 2001-agosto 2003
Authors: B Decludt, C Campese, D Che, S Jarraud, J Etienne
Journal: Eurosurveillance (2004)

Las agrupaciones de legionelosis requieren una atencion especial y son detectadas por el sistema nacional frances de vigilancia y por la red europea EWGLINET.
Entre septiembre de 2001 y agosto de 2003, se identificaron 37 agrupaciones de casos en lugares turisticos en Francia : 27 hoteles y 10 campings. La distribucion de los casos clinicos por agrupacion era la siguiente : 30 agrupaciones de dos casos (81%), seis agrupaciones de tres casos (16%) y una agrupacion de cuatro casos (3%), o sea, un total de 82 casos. Se realizaron investigaciones ambientales por las autoridades sanitarias locales en 36 de las 37 agrupaciones y se recogieron muestras de agua en 35 de ellas. Dieciseis lugares (46%) dieron positivo para Legionella pneumophila a un nivel superior a 103 ufc/litro. En todos los lugares donde se encontro que las medidas de evaluacion del riesgo eran inapropiadas, se tomaron inmediatamente medidas de control. Seis hoteles fueron cerrados inmediatamente tras las alertas de agrupaciones. 
La comparacion de las cepas clinicas y ambientales, hecha por electroforesis en gel de campo pulsado (PFGE), fue posible en tres agrupaciones, encontrandose identicos perfiles geneticos en todos los aislamientos. Durante estos dos anos de vigilancia, los resultados indican que ha habido un riesgo de exposicion a Legionella en numerosos lugares. Ello confirma la importancia del programa europeo de vigilancia y de la notificacion rapida de todos los casos a EWGLINET.
L'eradicazione della pertosse: una sfida per la sanità pubblica
Authors: S Salmaso
Journal: Eurosurveillance (1999)

Negli ultimi dieci anni, si e molto parlato di pertosse e di vaccinazione contro la pertosse, in particolare a causa di diversi studi clinici intrapresi in varie parti dell'Europa. Nondimeno, e ancora necessario chiarire molti importanti aspetti di sanita pubblica. I tre articoli presenti in questo numero di Eurosurveillance sono esemplificativi della situazione presente in diversi paesi europei e indicano le seguenti lezioni: l'introduzione della vaccinazione abbassa l'incidenza (come in Svezia); monitorare l'incidenza della pertosse puo essere difficile se cambiano degli elementi del sistema di sorveglianza (per migliorare la specificita diagnostica, in Svizzera, si e introdotta la reazione a catena della polimerasi - PCR - e, nei Paesi Bassi sono stati aggiunti criteri sierologici basati su titoli anticorpali); anche con un tasso di vaccinazione costantemente elevato, si possono verificare epidemie (come nei Paesi Bassi)