tbuckley/cabot-search huggingface dataset:
Adult Acute Leukemia: Cerebral Degeneration
Authors: IVAN P. LAW
Journal: Annals of Internal Medicine (1974)

Comments1 November 1974Adult Acute Leukemia: Cerebral DegenerationIVAN P. LAW, M.D., MAJ MCIVAN P. LAW, M.D., MAJ MCSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-5-709_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent reports of cerebral parenchymatous degeneration as a complication in children with central nervous system (CNS) leukemia and primary brain tumors who were treated with intrathecal methotrexate and cranial irradiation (1, 2) have prompted us to report this occurrence in an adult with acute lymphoblastic leukemia.This 21-year-old, white man with acute lymphoblastic leukemia was in remission for a year and then was found to have bone marrow relapse and meningeal involvement. A complete CNS remission was obtained with intrathecal methotrexate (12 mg/m2) and cranial irradiation with the midline dose of 2000 rads in 17 days. Six...References1. HENDIN B: Parenchymatous degeneration of the central nervous system in childhood leukemia. Cancer 33:468-482, 1974 CrossrefMedlineGoogle Scholar2. NORRELL H: Leukoencephalopathy following the administration of methotrexate into the cerebrospinal fluid in the treatment of primary brain tumors. Cancer 33:923-932, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hematology-Oncology Clinic Walter Reed Army Medical Center Washington, D.C. 20012 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdult acute leukemia.Frequency of central nervous system involvement in long term survivors 1 November 1974Volume 81, Issue 5Page: 709-709KeywordsBone marrowBrainCentral nervous systemChildrenMethotrexatePrecursor cells Issue Published: 1 November 1974 PDF downloadLoading ...
Total Parenteral Nutrition
Authors: David H. Law
Journal: New England Journal of Medicine (1977)

Total parenteral nutrition has been of clinical importance in the United States for less than a decade. Although it has not yet achieved its full status, its striking impact on medical practice and research has been expedited by numerous conferences and scientific meetings,1 , 2 and the development of textbooks and guides for its appropriate use.3 4 5 It necessitates a team approach with expertise in diverse areas, including technical and nursing skills, nutrition and metabolism. This review provides guidelines and references for current use, documents recognized problems and suggests future directions.There are two components of total parenteral nutrition: mechanical aspects of formulation . . .
Parkinson's Disease Dementia — A First Step?
Authors: Daniel Z. Press
Journal: New England Journal of Medicine (2004)

The hallmark of Parkinson's disease is involvement of the motor system, causing tremor, rigidity, and slowness of movement. But cognitive symptoms are frequently present at the time of diagnosis,1 contribute heavily to disability,2 and progress to dementia at an alarming rate. Dementia will develop in 40 to 70 percent of patients with Parkinson's disease during the course of their illness.3 The term “Parkinson's disease dementia” refers to dementia that develops at least two years after the diagnosis of Parkinson's disease. If dementia develops before or within two years after the onset of motor symptoms, then the criteria are met for . . .
Ménière's Disease
Authors: Andrew W Morrison
Journal: Journal of the Royal Society of Medicine (1981)

The otological practice at The London Hospital provides very large numbers of patients with Ménière's disease from a busy department. This clinical material has been utilized as much as possible, without research assistants or funds, to examine some clinical and pathological aspects of the disease which might have a bearing on aetiology. The investigation procedures which are likely to lead to an earlier and more certain diagnosis are outlined and prognostic indicators are mentioned. It would appear that there may be an hereditary predisposition to progressive idiopathic endolymphatic hydrops. Potential sufferers tend to have migraine, a family history of migraine, minor degrees of basilar impression associated with an abnormally located endolymphatic duct and sac, a more emotional personality, and possibly an association with blood group A. The experimental and clinicopathological evidence supports the view that the endolymphatic duct and sac have an important role in the pathogenesis of both idiopathic and secondary hydrops. Ultrastructural examination is continuing and may shed more light on the pathology at a cellular level. There is, as yet, no cure for Ménière's disease and sufferers will be incapacitated in varying degrees, often severely, for the rest of their days.
Desirability of the Routine Use of Tetanus Toxoid
Authors: Edward Press
Journal: New England Journal of Medicine (1948)

DURING the last few years a considerable amount of additional information regarding the effectiveness and hazards of active immunization against tetanus has become available. The war, with its many casualties among unimmunized, partly immunized and fully immunized civilian and military personnel, contributed greatly to this fund of information. In the light of this added knowledge and in view of the continuing diversity of opinion and practice regarding the routine active immunization of children and adults, it was believed that the entire problem deserved reevaluation. An effort was made to analyze objectively all the factors involved and to arrive at a . . .
TCT-357 Transcatheter Aortic Valve Replacement with a 34-mm Repositionable Self-Expanding Bioprosthesis
Authors: Tanvir Bajwa, Daniel P. O'Hair, Mathew Williams, Mubashir Mumtaz, Hemal Gada, Stanley Chetcuti, G. Michael Deeb, Jeffrey J. Popma
Journal: Journal of the American College of Cardiology (2017)
TCT-56 Transcatheter Mitral Valve Repair in Patients with Functional Mitral Regurgitation – One-Year Outcomes from the Multicenter CE Trial
Authors: Francesco Maisano, Karl-Heinz Kuck, Ottavio Alfieri, Antonio Colombo, Stephan Baldus, Jörg Hausleiter, Arthur Kerner, Corrado Tamburino, Jan van der Heyden, Ralph Stephan von Bardeleben, Alec Vahanian, Georg Nickenig
Journal: Journal of the American College of Cardiology (2017)
Prognostic role of body-mass index at diagnosis in gastric cancer: a systematic review and meta-analysis.
Authors: Sashidhar Manthravadi, Anuj Shrestha, Sheshadri Madhusudhana
Journal: Journal of Clinical Oncology (2016)

e15559 Background: Obesity is described to be a risk factor for gastric cancer in epidemiologic studies. Body mass index (BMI) is a known prognostic factor in several cancers. It also affects outcomes in the post-operative setting in gastric cancer (GC) but studies describing the impact of body mass index on long-term outcomes have had varying results. Methods: A systematic search of PubMed and Embase was performed to identify studies which described outcomes in GC patients with low or high BMI in comparison with those who were of normal weight. Outcomes in GC were categorized for four different groups namely low BMI ( < 18.5) high BMI (BMI > 25), overweight (BMI 25-30) and obesity (BMI > 30). Pooled hazard ratio (HR) with 95% confidence intervals (CI) for overall survival (OS) was estimated using the random effects model. Results: After reviewing 965 abstracts, 17 studies which met inclusion criteria were selected. A total of 19741 patients with GC were followed in these studies, of whom 4298 patients had high BMI (BMI > 25) and 586 patients were categorized as underweight. Of the 17 studies included, 7 reported outcomes in underweight patients and 15 studies reported outcomes in patients with BMI > 25. Among high BMI patients, further stratification on the basis of overweight and obesity was performed in 3 and 4 studies respectively. Being underweight was a predictor of adverse prognosis (HR 1.50; 95% CI 1.32- 1.72, I2= 0%). Meta-analysis of 15 studies showed improved OS in patients with high BMI (19316 patients, HR 0.87; 95% CI 0.77-0.98, I2= 63%). This association remained unchanged even when meta-analysis was restricted to patients with resected cancer. However, the survival benefit of higher body weight was restricted to overweight patients (HR 0.75; 95% CI 0.59- 0.95, I2= 20%). Obesity was not a prognostic indicator as seen in a meta-analysis of 4 studies (HR 0.97; 95% CI 0.76- 1.24). Conclusions: BMI has a complex relationship with long term survival in patients with gastric cancer, with the association best illustrated by a bell-shape curve. Additional studies are required in overweight and obese gastric cancer patients to evaluate treatment-related factors and variation in tumor biology that may explain these findings.
Warmth and competence as distinct dimensions of value in social emotions
Authors: Mina Cikara
Journal: Behavioral and Brain Sciences (2017)

Abstract Gervais &amp; Fessler's analysis collapses across two orthogonal dimensions of social value to explain contempt: relational value, predicted by cooperation, and agentic value, predicted by status. These dimensions interact to potentiate specific social emotions and behaviors in intergroup contexts. By neglecting the unique roles of these dimensions – and their associated attributes: warmth and competence – the sentiment framework cedes predictive precision.
Beating-Heart Mitral Valve Repair Using a Novel ePTFE Cordal Implantation Device
Authors: James S. Gammie, Krzysztof Bartus, Andrzej Gackowski, Michael N. D’Ambra, Piotr Szymanski, Agata Bilewska, Mariusz Kusmierczyk, Boguslaw Kapelak, Jolanta Rzucidlo-Resil, Neil Moat, Alison Duncan, Rashmi Yadev, Steve Livesey, Paul Diprose, Gino Gerosa, Augusto D’Onofrio, Demetrio Pitterello, Paolo Denti, Giovanni La Canna, Michele De Bonis, Ottavio Alfieri, Judy Hung, Piotr Kolsut
Journal: Journal of the American College of Cardiology (2017)
Are Surgical Residents Prepared to Care for Transgender Patients?—Reply
Authors: Brandyn D. Lau, Adele Levine, Adil H. Haider
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
TCT-387 Collateral quality decay several days after primary PCI: a novel observation from the EXPLORE trial.
Authors: Ivo M. van Dongen, Joelle Elias, K. Gert van Houwelingen, Pierfrancesco Agostoni, Bimmer EPM Claessen, Loes P. Hoebers, Dagmar Ouweneel, Rene van der Schaaf, Jan Tijssen, Jose PS Henriques
Journal: Journal of the American College of Cardiology (2017)
Can a modified esophageal stent be useful in the treatment of nonresponsive benign colonic anastomotic stenosis?
Authors: Benedetto Mangiavillano, Mario Bianchetti, Alessandro Repici
Journal: Endoscopy (2017)

A 77-year-old woman with history of anterior rectal resection for neoplasia in 1998, followed by chemo- and radiotherapy, was referred to our unit because of an increase in subocclusive episodes (1 – 2 times a week) over the previous 5 months, due to a stenosis extending to 5 cm above the colorectal anastomosis. The patient had previously undergone several pneumatic dilation procedures for anastomotic stenosis, with substenosis of the colon above, following radiotherapy.
Calcium Phosphate–Collagen Scaffold with Aligned Pore Channels for Enhanced Osteochondral Regeneration
Authors: Yun‐Jeong Seong, In‐Gu Kang, Eun‐Ho Song, Hyoun‐Ee Kim, Seol‐Ha Jeong
Journal: Advanced Healthcare Materials (2017)

Abstract This study reports the development of a bilayered scaffold with aligned channels produced via a sequential coextrusion and unidirectional freezing process to facilitate upward bone‐marrow stem‐cell migration. The biomimetic scaffold with collagen and biphasic calcium phosphate (BCP) layers is successfully fabricated with matching of the cartilage and bone layers. The aligned structure results in an enhancement of the compressive strength, and the channels enable tight anchoring of the collagen layers on the BCP scaffolds compared with a randomly structured porous scaffold. An in vitro evaluation demonstrates that the aligned channels guide the cells to attach on the surface in highly stretched shapes and migrate upward faster than the random structure. In addition, in vivo assessment reveals that the aligned channels yield superior osteochondral tissue regeneration compared with the random structure. Moreover, the channel diameter greatly affects the tissue regeneration, and the scaffold with a channel diameter of ≈270 µm exhibits the optimal regeneration because of sufficient nutrient supply and adequate tissue ingrowth. These findings indicate that the introduction of aligned channels to a bilayered scaffold provides an effective approach for osteochondral tissue regeneration.
Abstract 16568: Investigation of Adverse Outcomes in Pregnant Women With Pulmonary Hypertension at the Time of Delivery
Authors: Erin Thomas, Fabio V Lima, Jianjin Xu, Jie Yang, Kathleen Stergiopoulos
Journal: Circulation (2016)

Introduction: Pregnant women with heart disease often have major adverse cardiac events (MACE) during delivery. Pulmonary hypertension (PH) has been widely presumed to be a strong contraindication ...
Adjuvant FEC-D: Dose intensity and survival—What is optimal?
Authors: Ishtiaq Husain Zubairi, Nicola Steele, Aysha Al Zaman, Judith Fraser, Alison Yule
Journal: Journal of Clinical Oncology (2014)

e12001 Background: Dose intensity has long been felt to be important in achieving maximal benefit (disease free and overall survival) from chemotherapy regimes in the adjuvant breast cancer setting. However, increasing dose intensity increases toxicity. Although many studies report dose intensity, few report the longer-term relationship between dose intensity achieved and survival benefit. Methods: A retrospective review was performed on 101 consecutive patients treated with FEC-D (FE100C x 3 docetaxel 100 mg/m2x 3) between Jan 2006 and Dec 2007 and the relative dose intensity for docetaxel calculated. The relationship between dose intensity and outcome was explored and related to outcomes in the PACS-01 trial (primary endpoint DFS, secondary endpoint OS, n=1,999). Results: Median age was 54 yrs (range 30-70). 43% ER positive, 52% HER2 positive (see Table). Extraction of patients receiving <85% docetaxel dose intensity (22 patients) showed DFS of 77.3%, OS 81.8% (18 patients alive), and with 41 patients receiving ≤ 90% dose intensity with a DFS of 78.1% and OS of 85.4%. Conclusions: We have no comparable group in PACS 01 where survival is directly related to dose intensity and our numbers are too few to draw any significant conclusion. Given the increased toxicity seen with the FE100C-D regime in the general population compared to the trial population (published), however, our data suggest that the dose of docetaxel could safely be reduced to 90mg/m2 with no reduction in DFS or efficacy. Further loss of dose intensity however would appear to reduce benefit, and confirms the few earlier studies where this has been reported. Further investigation of this in larger patient cohorts is warranted to help inform the oncology community regarding dose reduction and delay policies for current and future chemotherapy regimes. Lower overall survival in our cohort can in part be explained by poorer prognosis disease of our patient cohort, deaths due to causes other than recurrent cancer and comorbidities. Our smaller sample could contribute to sampling bias regarding OS. At 60 months PACS 1 FEC-D arm PACS 1 FEC x 6 arm Current study DFS 78.4 % 73.2% 75.3 % Overall survival 90.7% 86.7% 84.2% Deaths from causes other than recurrent breast cancer 1.1% 1.2% 3%
A Deep Phenotype Association Study Reveals Specific Phenotype Associations with Genetic Variants in Age-related Macular Degeneration
Authors: Freekje van Asten, Michael Simmons, Ayush Singhal, Tiarnan D. Keenan, Rinki Ratnapriya, Elvira Agrón, Traci E. Clemons, Anand Swaroop, Zhiyong Lu, Emily Y. Chew
Journal: Ophthalmology (2017)
TCT-180 Impact of Chronic Obstructive Pulmonary Disease in Patients with Left Main Disease Randomized to PCI vs. CABG: A Propensity Score Matched Analysis From the EXCEL Trial
Authors: Xin Huang, Bjorn Redfors, Shmuel Chen, Yangbo Liu, Ori Ben-Yehuda, David Kandzari, Roxana Mehran, Ad van Boven, Piet Willem Boonstra, Joseph Sabik, Patrick Serruys, A. Pieter Kappetein, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture
Authors: Laura C. Graham, Samantha L. Eaton, Paula J. Brunton, Abdelmadjid Atrih, Colin Smith, Douglas J. Lamont, Thomas H. Gillingwater, Giuseppa Pennetta, Paul Skehel, Thomas M. Wishart
Journal: Molecular Neurodegeneration (2017)

Neurons are highly polarized cells consisting of three distinct functional domains: the cell body (and associated dendrites), the axon and the synapse. Previously, it was believed that the clinical phenotypes of neurodegenerative diseases were caused by the loss of entire neurons, however it has recently become apparent that these neuronal sub-compartments can degenerate independently, with synapses being particularly vulnerable to a broad range of stimuli. Whilst the properties governing the differential degenerative mechanisms remain unknown, mitochondria consistently appear in the literature, suggesting these somewhat promiscuous organelles may play a role in affecting synaptic stability. Synaptic and non-synaptic mitochondrial subpools are known to have different enzymatic properties (first demonstrated by Lai et al., 1977). However, the molecular basis underpinning these alterations, and their effects on morphology, has not been well documented. The current study has employed electron microscopy, label-free proteomics and in silico analyses to characterize the morphological and biochemical properties of discrete sub-populations of mitochondria. The physiological relevance of these findings was confirmed in-vivo using a molecular genetic approach at the Drosophila neuromuscular junction. Here, we demonstrate that mitochondria at the synaptic terminal are indeed morphologically different to non-synaptic mitochondria, in both rodents and human patients. Furthermore, generation of proteomic profiles reveals distinct molecular fingerprints – highlighting that the properties of complex I may represent an important specialisation of synaptic mitochondria. Evidence also suggests that at least 30% of the mitochondrial enzymatic activity differences previously reported can be accounted for by protein abundance. Finally, we demonstrate that the molecular differences between discrete mitochondrial sub-populations are capable of selectively influencing synaptic morphology in-vivo. We offer several novel mitochondrial candidates that have the propensity to significantly alter the synaptic architecture in-vivo. Our study demonstrates discrete proteomic profiles exist dependent upon mitochondrial subcellular localization and selective alteration of intrinsic mitochondrial proteins alters synaptic morphology in-vivo.
TCT-538 Angiographic and mid-term clinical outcomes of bioresorbable vascular scaffold for coronary bifurcation lesions. Data from Maasstad Hospital
Authors: Valeria Paradies, Georgios Vlachojannis, Kees-Jan Royaards, Jochem Wassing, Martin van der Ent, Pieter Smits
Journal: Journal of the American College of Cardiology (2017)
Tumor infiltrating lymphocytes as a predictive factor in Pertuzumab/Trastuzumab-treated HER2-positive breast cancer
Authors: Kanako Saito, Yuji Kotsuka, Hiroyasu Oda, Mikiya Ishihara, Satoshi Tamaru, Yoshiki Yamashita, Toshiro Mizuno, Naoyuki Katayama
Journal: Annals of Oncology (2017)
TCT-697 Leaflet-to-Annulus Index: an echocardiographic predictor of outcomes in patients treated with Neochord repair procedure
Authors: Andrea Colli, Erica Manzan, Eleonora Bizzotto, Laura Besola, Nicola Pradegan, Alessandro Fiocco, Matteo Nadali, Roberto Bellu, Danila Azzolina, Demetrio Pittarello, Gino Gerosa
Journal: Journal of the American College of Cardiology (2017)
Depressive symptoms, depression, and the effect of biologic therapy among patients in Psoriasis Longitudinal Assessment and Registry (PSOLAR)
Authors: Bruce Strober, Melinda Gooderham, Elke M.G.J. de Jong, Alexa B. Kimball, Richard G. Langley, Nikita Lakdawala, Kavitha Goyal, Fabio Lawson, Wayne Langholff, Lori Hopkins, Steve Fakharzadeh, Bhaskar Srivastava, Alan Menter
Journal: Journal of the American Academy of Dermatology (2017)

Patients with psoriasis are at an increased risk for depression. However, the impact of treatment on this risk is unclear.Evaluate the incidence and impact of treatment on depression among patients with moderate-to-severe psoriasis.We defined a study population within the Psoriasis Longitudinal Assessment and Registry and measured the incidence of depressive symptoms (Hospital Anxiety and Depression Scale-Depression score ≥8) and adverse events (AEs) of depression within cohorts receiving biologics, conventional systemic therapies, or phototherapy. Patients were evaluated at approximately 6-month intervals. Multivariate modeling determined the impact of treatment on risk.The incidence rates of depressive symptoms were 3.01 per 100 patient-years (PYs) (95% confidence interval [CI], 2.73-3.32), 5.85 per 100 PYs (95% CI, 4.29-7.97), and 5.70 per 100 PYs (95% CI, 4.58-7.10) for biologics, phototherapy, and conventional therapy, respectively. Compared with conventional therapy, biologics reduced the risk for depressive symptoms (hazard ratio, 0.76; 95% CI, 0.59-0.98), whereas phototherapy did not (hazard ratio, 1.05; 95% CI, 0.71-1.54). The incidence rates for AEs of depression were 0.21 per 100 PYs (95% CI, 0.15-0.31) for biologics, 0.55 per 100 PYs (95% CI, 0.21-1.47) for phototherapy, and 0.14 per 100 PYs (95% CI, 0.03-0.55) for conventional therapy; the fact that there were too few events (37 AEs) precluded modeling.Incomplete capture of depression and confounders in the patients on registry.Compared with conventional therapy, biologics appear to be associated with a lower incidence of depressive symptoms among patients with psoriasis.
Unexpected Pyelonephritis Incidentally Revealed on 99mTc MDP Bone Scintigraphy
Authors: Xiaofei Zhao, Ruifang Zhao, Ha Wu
Journal: Clinical Nuclear Medicine (2017)

Abstract A 5-year-old girl had intermittent fever for 4 months. A 99m Tc MDP bone scintigraphy was performed to evaluate possible occult osteomyelitis, which revealed no bone lesion. However, abnormal MDP activity in the upper poles of both kidneys was noted, which was confirmed as pyelonephritis subsequently.
Randomized Phase II Trial Comparing CDDP+TS-1+TRT and CDDP+DTX+TRT in Locally Advanced NSCLC (TORG1018)
Authors: Makiko Yomota, Yukio Hosomi, Tsuneo Shimokawa, Hiroaki Okamoto, Kazuhiko Yamada, Hiroshi Tanaka, Kaoru Kubota, Kazuma Kishi, Takeharu Yamanaka, Koshiro Watanabe
Journal: Annals of Oncology (2017)