tbuckley/cabot-search huggingface dataset:
Demographic and evolutionary trends in ovarian function and aging
Authors: Triin Laisk, Olga Tšuiko, Tatjana Jatsenko, Peeter Hõrak, Marjut Otala, Mirkka Lahdenperä, Virpi Lummaa, Timo Tuuri, Andres Salumets, Juha S Tapanainen
Journal: Human Reproduction Update (2018)

The human female reproductive lifespan is regulated by the dynamics of ovarian function, which in turn is influenced by several factors: from the basic molecular biological mechanisms governing folliculogenesis, to environmental and lifestyle factors affecting the ovarian reserve between conception and menopause. From a broader point of view, global and regional demographic trends play an additional important role in shaping the female reproductive lifespan, and finally, influences on an evolutionary scale have led to the reproductive senescence that precedes somatic senescence in humans.The narrative review covers reproductive medicine, by integrating the molecular mechanisms of ovarian function and aging with short-term demographic and long-term evolutionary trends.PubMed and Google Scholar searches were performed with relevant keywords (menopause, folliculogenesis, reproductive aging, reproductive lifespan and life history theory). The reviewed articles and their references were restricted to those written in English.We discuss and summarize the rapidly accumulating information from large-scale population-based and single-reproductive-cell genomic studies, their constraints and advantages in the context of female reproductive aging as well as their possible evolutionary significance on the life history trajectory from foetal-stage folliculogenesis until cessation of ovarian function in menopause. The relevant environmental and lifestyle factors and demographic trends are also discussed in the framework of predominant evolutionary hypotheses explaining the origin and maintenance of menopause.The high speed at which new data are generated has so far raised more questions than it has provided solid answers and has been paralleled by a lack of satisfactory interpretations of the findings in the context of human life history theory. Therefore, the recent flood of data could offer an unprecedented tool for future research to possibly confirm or rewrite human evolutionary reproductive history, at the same time providing novel grounds for patient counselling and family planning strategies.
A Prospective Cohort Study of Postdischarge Opioid Practices After Radical Prostatectomy: The ORIOLES Initiative
Authors: Hiten D. Patel, Arnav Srivastava, Neil D. Patel, Farzana A. Faisal, Wesley Ludwig, Gregory A. Joice, Zeyad R. Schwen, Mohamad E. Allaf, Misop Han, Amin S. Herati
Journal: European Urology (2018)
Ex vivo and in vivo T cell-depleted allogeneic stem cell transplantation in patients with acute myeloid leukemia in first complete remission resulted in similar overall survival: on behalf of the ALWP of the EBMT and the MSKCC
Authors: Florent Malard, Myriam Labopin, Christina Cho, Didier Blaise, Esperanza B. Papadopoulos, Jakob Passweg, Richard O’Reilly, Edouard Forcade, Molly Maloy, Liisa Volin, Hugo Castro-Malaspina, Yosr Hicheri, Ann A. Jakubowski, Corentin Orvain, Sergio Giralt, Mohamad Mohty, Arnon Nagler, Miguel-Angel Perales
Journal: Journal of Hematology & Oncology (2018)

Graft-versus-host disease (GVHD) is one of the leading causes of non-relapse mortality and morbidity after allogeneic hematopoietic stem cell transplantation (allo-HCT). We evaluated the outcomes of two well-established strategies used for GVHD prevention: in vivo T cell depletion using antithymocyte globulin (ATG) and ex vivo T cell depletion using a CD34-selected (CD34+) graft. A total of 525 adult patients (363 ATG, 162 CD34+) with intermediate or high-risk cytogenetics acute myeloid leukemia (AML) in first complete remission (CR1) were included. Patients underwent myeloablative allo-HCT using matched related or unrelated donors. Two-year overall survival estimate was 69.9% (95% CI, 58.5–69.4) in the ATG group and 67.6% (95% CI, 60.3–74.9) in the CD34+ group (p = 0.31). The cumulative incidence of grade II–IV acute GVHD and chronic GVHD was higher in the ATG cohort [HR 2.0 (95% CI 1.1–3.7), p = 0.02; HR 15.1 (95% CI 5.3–42.2), p < 0.0001]. Parameters associated with a lower GVHD-free relapse-free survival (GRFS) were ATG [HR 1.6 (95% CI 1.1–2.2), p = 0.006], adverse cytogenetic [HR 1.7 (95% CI 1.3–2.2), p = 0.0004], and the use of an unrelated donor [HR 1.4 (95% CI 1.0–1.9), p = 0.02]. There were no statistical differences between ATG and CD34+ in terms of relapse [HR 1.52 (95% CI 0.96–2.42), p = 0.07], non-relapse mortality [HR 0.96 (95% CI 0.54–1.74), p = 0.90], overall survival [HR 1.43 (95% CI 0.97–2.11), p = 0.07], and leukemia-free survival [HR 1.25 (95% CI 0.88–1.78), p = 0.21]. Significantly, more deaths related to infection occurred in the CD34+ group (16/52 vs. 19/112, p = 0.04). These data suggest that both ex vivo CD34-selected and in vivo ATG T cell depletion are associated with a rather high OS and should be compared in a prospective randomized trial.
GW29-e1464 Inappropriate Shock therapy of Implantable Cardioverter Defibrillator and Cardiac Resynchronization Therapy Defibrillator in patients with Atrial Fibrillation, and the Impact of Atrial Ventricular Node Ablation on the Outcome
Authors: Weijian Huang, Songjie Wang, Shengjie Wu, Lan Su, Lei Xu, Fangyi Xiao
Journal: Journal of the American College of Cardiology (2018)
Individuals Fulfilling Criteria for Type 2 Diabetes Rather Than LADA Display Transient Signs of Autoimmunity Preceding Diagnosis With Possible Clinical Implications: The HUNT Study
Authors: Elin P. Sørgjerd, Bjørn O. Åsvold, Per M. Thorsby, Valdemar Grill
Journal: Diabetes Care (2018)

Latent autoimmune diabetes in adults (LADA) is classified as type 1 diabetes because of autoantibody positivity. In contrast, individuals classified as having type 2 diabetes are by definition autoantibody negative. However, autoantibodies may fluctuate (1). We therefore examined whether some individuals have transient evidence of autoimmunity preceding a diagnosis of type 2 diabetes and whether their clinical characteristics differ from those of other individuals classified as having type 2 diabetes.

The study was performed among participants of the second (HUNT2, 1995–1997) and third (HUNT3, 2006–2008) surveys of the Nord-Trondelag Health Study (HUNT) in Norway. Details about HUNT are available elsewhere (2,3). Participants with self-reported diabetes in HUNT3 ( n = 2,264) were given a detailed diabetes-related questionnaire and invited to a follow-up clinical investigation that included measurements of hemoglobin A1c (HbA1c), fasting glucose, C-peptide, and the autoantibodies GADA and islet antigen-2 (IA-2A).

We investigated participants with incident type 2 diabetes between HUNT2 and HUNT3 ( n = 965), defined as diabetes without GADA and IA-2A in HUNT3 and no insulin treatment within 1 year after diagnosis. Among them, 171 participants were excluded due to lack of serum samples or possible unknown diabetes at HUNT2, as indicated by nonfasting serum glucose >11.0 mmol/L in HUNT2. Serum samples that were collected during the HUNT2 …
GW29-e0029 An Attempt To Correct Myocardial Morphological Changes On An Animal Experimental Model Of Hypoosomalar Hyperhydration By Means Of Meldonium
Authors: Yarmolenko Olga, Bumeister Valentyna, Prykhodko Olga, Demikhova Nadiia, Bumeister Lina
Journal: Journal of the American College of Cardiology (2018)
VOTRAGE study pazopanib in a population of “frail” elderly patients after geriatric assessment: A phase I study with geriatric criteria
Authors: L. Mourey, A. Ravaud, L. Digue, B. Cabarrou, C.A. Gomez-Roca, T. Valentin, P. Olivier, A. Fabre, M. Mounier, L. Balardy, T. Filleron
Journal: Annals of Oncology (2018)
P3.13-20 Frequency of EGFR Mutations in Patients with Adenocarcinoma Lung Cancer. Comparative Study Between Public and Private Mexican Health Services
Authors: G. Martos Ramírez, V. García Montes, D. Bonilla-Molina, J.A. Alatorre Alexander, G. Olivares Beltrán, V. Imaz-Olguín, D. Green Renner, J. Rodriguez-Cid
Journal: Journal of Thoracic Oncology (2018)
Third-Line Nivolumab Monotherapy in Recurrent SCLC: CheckMate 032
Authors: Neal Ready, Anna F. Farago, Filippo de Braud, Akin Atmaca, Matthew D. Hellmann, Jeffrey G. Schneider, David R. Spigel, Victor Moreno, Ian Chau, Christine L. Hann, Joseph Paul Eder, Nicola L. Steele, Anne Pieters, Justin Fairchild, Scott J. Antonia
Journal: Journal of Thoracic Oncology (2018)
A phase Ib/II study of durvalumab combined with dose-dense EC in neoadjuvant setting for patients with locally advanced luminal B HER2(-) or triple negative breast cancers (B-IMMUNE)
Authors: A. Devaux, J.-L. Canon, F.P. Duhoux, P. Delrée, C. Galant, P.G. Coulie, I. Bar, M. Constant, S. Haussy, O. Bricard, K. Missault, M. Berlière, T. Willems, J. Carrasco
Journal: Annals of Oncology (2018)
Abstract 17256: The Walking Impairment Questionnaire Stair-Climbing Score Predicts Mortality in Patients With Peripheral Arterial Disease
Authors: Atul Jain, Kiang Liu, Luigi Ferrucci, Michael H Criqui, Lu Tian, Jack M Guralnik, Huimin Tao, Mary M McDermott
Journal: Circulation (2010)

Background: The Walking Impairment Questionnaire (WIQ) is a validated measure of patient-reported walking distance, walking speed, and stair climbing in men and women with lower extremity periphera...
Abstract 16944: Activation of the STING Cytosolic DNA Sensor Signaling Contributes to Aortic Aneurysm, Dissection and Rupture in Mice
Authors: Wei Luo, Lin Zhang, Yun Mao, Pingping Ren, Chen Zhang, Chris Guardado, Michelle S Zhang, Joseph S Coselli, Scott A LeMaire, Ying H Shen
Journal: Circulation (2017)

Introduction: Aortic aneurysm and dissection (AAD) carries significant mortality and morbidity. Identifying molecules that are responsible for aortic destruction is critical for developing effectiv...
What is the role of surgery in potentially resectable N2 non-small cell lung cancer?
Authors: Matthew Evison, Fiona McDonald, Tim Batchelor
Journal: Thorax (2018)

► The optimum treatment for potentially resectable stage III N2 non-small cell lung cancer (NSCLC) is multimodality treatment targeting the prevention of distant disease with systemic therapy and achieving local control through surgery, radiotherapy or both.► An approach of induction treatment followed by surgery and surgery followed by adjuvant treatment both appear justified, though there is evidence suggesting higher treatment completion rates with an induction approach.► When definitive chemoradiotherapy is the preferred treatment option this should be delivered concurrently in the context of adequate physiological reserve.► Single station versus multistation N2 disease should not be used as treatment defining factor.► Complex multimodality treatments require experienced and high-volume multidisciplinary teams and centres to minimise the risks from treatment and maximise benefits.Consideration should be given to dedicated regional stage III NSCLC services.
BAROCCO: A randomized phase II study of weekly paclitaxel vs cediranib-olaparib with continuous schedule vs cediranib-olaparib with intermittent schedule in advanced platinum resistant ovarian cancer
Authors: N. Colombo, O. Nicoletto, P. Benedetti Panici, G. Tognon, A.A. Lissoni, A. Bologna, F. Tomao, R. Fossati, F. Tettamanzi, E. Rulli, F. Galli, M.F. Alvisi, V. Torri, E. Biagioli
Journal: Annals of Oncology (2018)
Multidisciplinary lung cancer tumor board connecting eight hospitals via the high-security communication line
Authors: Takayuki Takeda, Kiyoaki Uryu, Yoshio Ichihashi, Hiromasa Harada, Akihiko Iwase, Yukihiro Tamura, Mayumi Takeuchi, Yukie Shimizu, Makoto Hibino, Shigeto Horiuchi, Shin Hirayama, Hisanori Kani, Hiroshi Tsukuda
Journal: Annals of Oncology (2018)
Abstract P081: Late-onset Asthma Predicts Cardiovascular Disease Events: The Wisconsin Sleep Cohort
Authors: Matthew C Tattersall, Jodi H Barnet, Claudia E Korcarz, Erika W Hagen, Paul E Peppard, James H Stein
Journal: Circulation (2016)

Background: Asthma is a heterogeneous syndrome with different clinical subtypes that is associated with an increased risk for cardiovascular disease (CVD). We hypothesized that the late-onset subtype of asthma is associated with a higher risk of incident CVD. Methods: Presence of asthma and age of diagnosis were assessed at baseline in the ongoing population-based Wisconsin Sleep Cohort study, an investigation of sleep, respiratory and cardiovascular outcomes in adults followed prospectively since 1988. Late-onset asthma was defined as physician-diagnosed asthma at age 18 years or older. Participants were free of baseline CVD and followed for a mean (standard deviation) 13.9 (5.9) years for development of CVD (coronary death, myocardial infarction, angina, stroke, coronary revascularization, heart failure, or CVD death). Multivariable Cox regression models adjusted for age, sex, smoking, hypertension, body-mass index (BMI), and presence of diabetes mellitus were used to assess associations of late-onset asthma and incident CVD. Results: The 1269 participants were 47.3 (8.0) years old; 166 participants had asthma (111 with late-onset asthma, 55 early-onset asthma and 1103 without asthma). Participants with late-onset asthma compared to non-asthmatics were more likely to be female (67% vs 44%), have a higher BMI (32.2 vs 29.4 kg/m2) and more likely to be hypertensive (38% vs 29%) (all p&lt;0.05). Mean age of asthma diagnosis in the late-onset group was 39.5 (9.6) years vs. 8.9 (5.7) years in the early onset group (p&lt; 0.0001). After adjustment for confounders, late-onset asthmatics had a higher risk of incident CVD events than non-asthmatics (Hazard Ratio 1.57, 95% confidence intervals 1.01-2.45, p=0.045, see figure). There was no interaction between BMI and age of asthma diagnosis on incident CVD (p=0.83). Discussion: In a large cohort study of adults followed prospectively for over a decade, only late-onset asthmatics had an increased risk of incident CVD events. CVD risk associated with asthma may depend on asthma subtype.
GW29-e0045 Salt Loading on Plasma Osteoprotegerin and Protective Role of Potassium Supplement in Normotensive Subjects
Authors: Fuqiang Liu, Yong Zhang, Shuang Shi, Ling Zhu, Yujie Xing, Jiang Lei, Shuo Pan, Gongchang Guan, Junkui Wang
Journal: Journal of the American College of Cardiology (2018)
Abstract 13289: Reduction in Extracellular Volume Fraction After Mitral Valve Repair of Chronic Mitral Regurgitation: A Cardiac MRI Pilot Study
Authors: Eric Y Yang, Mohamad Ghosn, Mohammad A Khan, Nickalaus L Gramze, Eleonora Avenatti, Gerd Brunner, Faisal Nabi, Stephen H Little, Vijay Nambi, Christie M Ballantyne, Gerald M Lawrie, William A Zoghbi, Dipan J Shah
Journal: Circulation (2016)

Background: Global extracellular volume fraction (ECV) assessed with cardiac magnetic resonance (CMR) has been shown to be elevated in patients with chronic mitral regurgitation compared with healthy controls. Limited work has been published on ECV changes following reduction in chronic volume overload with mitral valve intervention. We examined changes in ECV in patients with chronic mitral valve regurgitation after surgical mitral valve repair (SMVR). Methods: All patients underwent CMR studies before and after SMVR. CMR studies were performed with cine, phase contrast, T1 maps, and late gadolinium enhancement (LGE) imaging. Mid, short axis T1 maps were divided into 6 cardiac segments, each classified as LGE absent or present. ECV was derived from T1 maps using area-weighted averages of only segments where LGE was absent, by a reader blinded to study date, clinical history and valve status. Results: Fifteen patients underwent SMVR a median of 1.4 (interquartile range [IQR] 0.8, 2.3) months after an initial CMR study (Table). Repeat CMR was performed a median 12.4 (IQR 7.2, 19.2) months after SMVR. None were on calcium channel blockers, nitrates, or direct arterial vasodilators. Following SMVR, significant reverse remodeling was seen with reductions in indexed left atrial volume and left ventricular parameters except end systolic volume (Table). ECV decreased from a mean 28.3% to 26.0% (p=0.01) (Table). No significant correlation was seen between changes in left sided CMR parameters and ECV (p=NS). Conclusion: In this pilot study of patients with significant chronic mitral regurgitation undergoing valve repair, a reduction in extracellular volume fraction was seen after 6 months or more, suggesting a decrease in myocardial fibrosis alongside reverse structural remodeling. Larger studies are needed to substantiate these findings and evaluate the clinical significance of ECV changes beyond cardiac reverse remodeling in patients undergoing mitral valve repair.
Molecular characterization and search for founding effects in Canarian families with hereditary breast and ovarian cancer syndrome
Authors: E. Llabres Valenti, A.M. Sanchez de Abajo, J. Brenes Castro, A. Ramchandani Vaswani, A. Gómez de Liaño, A. Hernández, M. Cejuela, J.A. Rodriguez Garcia, E. González, E. Vicente
Journal: Annals of Oncology (2018)
<i>Notes from the Field:</i> Reference Laboratory Investigation of Patients with Clinically Diagnosed Lyme Disease and Babesiosis — Indiana, 2016
Authors: Jennifer A. Brown, Rex Allman, Barbara L. Herwaldt, Elizabeth Gray, Hilda N. Rivera, Yvonne Qvarnstrom, Natalie Kwit, Martin E. Schriefer, Alison Hinckley, Pamela Pontones
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

In June 2016, a physician in northwestern Indiana reported a high prevalence of clinically diagnosed Lyme disease among his patients. To further evaluate these findings, the Indiana State Department of Health and CDC conducted a laboratory investigation using specimens from some of the patients.
Abstract 14976: Ventricular Assist Device Support in Pediatric Patients With Single Ventricle Heart Disease
Authors: Sharon Chen, Jenna Murray, David N Rosenthal, Christopher S Almond, John Dykes, Vamsi V Yarlagadda, Michael Ma, Manchula Navaratnam, Olaf Reinhartz, Katsuhide Maeda
Journal: Circulation (2017)

Introduction: As the number of children with single ventricle (SV) heart disease listed for heart transplants increases, there is a need for improved outcomes in the use of ventricular assist devic...
Abstract 11779: Third Generation Cryoballoon Facilitates Time-to-Isolation Dependent Freeze Protocols
Authors: Kerstin Petscher, Alexander Pott, Wolfgang Rottbauer, Tillman Dahme
Journal: Circulation (2016)

The introduction of the 2 nd generation cryoballoon (Medtronic Arctic Front Advance, AFA) increased efficacy of cryoballoon pulmonary vein (PV) isolation. Real time monitoring of the time-to-isolation (TTI) with a diagnostic spiral mapping catheter introduced through the cryoballoon inner lumen has emerged as a valuable parameter to estimate the quality of the ablation lesion. A short TTI appears to be predictive of a durable isolation, whereas a long TTI is linked to increased risk of PV reconnection. Real-time recording of TTI is limited in AFA due to a long distal tip of the balloon, which often inhibits registration of PV signals. A modification of the balloon design with a shorter tip (Medtronic Arctic Front Advance ST, AFA-ST) is supposed to facilitate registration of PV signals during isolation, because the spiral mapping catheter can be placed within the muscular sleeve of the PV. We have compared PV isolations with either the AFA-ST or the AFA cryoballoon and have implemented a protocol in the AFA-ST group depending on the observed TTI: In case of TTI &lt;30s the freeze-cycle was reduced to 120s, in case of TTI of 30s or more the freeze cycle was set to 180s. If TTI was more than 60s we added a 180s bonus freeze. In contrast, in the AFA group all PVs were isolated by an initial freeze cycle of 240s followed by a 240s bonus freeze. We included 74 patients in this non-randomized case-control trial, with 37 patients in each group. In each group we identified 149 PVs. All PVs were isolated successfully. Mean procedure duration was 107 ±19 min in the AFA group and 85 ±20 min in the AFA-ST group (p&lt;0.001). In the AFA group we registered a TTI in 83 PVs (55.7%), whereas TTI was documented in 122 PVs (81.9%) in the AFA-ST group (p&lt;0.001). Mean TTI was 44 ±25s in the AFA group and 42 ±22 s in the AFA-ST group (p=0.25). Patients were followed-up for an average period of 6.2 ±2.9 months. The Kaplan-Meier estimated freedom from atrial arrhythmia recurrence 6 months after the procedure was 88.9% in the AFA group and 81.6% in AFA-ST group (p=0.300). In conclusion, we here demonstrate, that registration of TTI occurs significantly more frequent with the new AFA-ST cryoballoon. Thus tailoring of freeze cycle duration is feasible and leads to comparable clinical outcomes to standard fixed freeze cycles.
Network meta‐analyses of systemic treatments for psoriasis: a critical appraisal
Authors: A.G. Ellis, C. Flohr, A.M. Drucker
Journal: British Journal of Dermatology (2018)

There are numerous systemic medications in use for psoriasis, with additional investigational agents being studied. However, head-to-head, randomized clinical trials are rare and cannot feasibly compare all treatments. A network meta-analysis (NMA) synthesizes the available evidence to provide estimates for all pairwise comparisons. Here, we summarize and appraise two recent NMAs that assessed systemic therapies for moderate-to-severe psoriasis. Two systematic reviews searched databases and the grey literature to identify relevant randomized clinical trials. The reviews mostly included trials that involved adults with moderate-to-severe psoriasis. One of the reviews also included two trials involving children. Interventions common to both reviews include adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, secukinumab and methotrexate. One of the reviews included additional interventions, primarily other biological agents along with new small-molecule treatments and systemic conventional treatments. One review focused on 'clear/nearly clear' and withdrawals from adverse events as study outcomes, while the second review focused on improvement of ≥ 90% measured on the Psoriasis Area and Severity Index (PASI 90) and serious adverse events. Additional outcomes included quality of life, PASI 75, Physician's Global Assessment of 0/1 and any adverse event. Overall, both NMAs are of high quality and provide a comprehensive summary of the evidence base and treatment effects. Results, in terms of both estimates and rankings, suggest that newer biologics targeting the interleukin (IL)-12/23 and IL-17 axes appear to be more effective than older biologics and oral agents. Patients, clinicians and policy makers can use the relative efficacy assessments of NMAs to inform decision making regarding the clearance of psoriasis skin lesions at relevant time points and improvement in quality of life.
GW29-e1794 Thioredoxin-1 promotes revers cholesterol transport levels to inhibit the development of atherosclerosis in vivo by enhancing the expression of ABCA1
Authors: Xiong Wang, Ling Zhang, Yi Liu, Shan Wang, Congye Li, Miaomiao Fan, Ling Tao
Journal: Journal of the American College of Cardiology (2018)
GW29-e0970 Foxc1 Maintains the Endothelial Progenitor Cell Niche and Rejuvenates Ischemic Aged-Myocardial Repair through Mediation of eNOS-Dependent β-catenin Signalling
Authors: Shaoheng Zhang, Zhao Lan, Wang Jiahong, Chen Nannan, Huang Weiguang, Su Feng, Cui Jin
Journal: Journal of the American College of Cardiology (2018)
GW29-e1697 Activation of Farnesoid X Receptor enhances the survival of engrafted adipose-derived mesenchymal stem cells in mouse post-MI heart
Authors: Wenjun Yan, Yunlong Xia, Fuyang Zhang, Yongzhen Guo, Yanjie Guo, Yuan He, Yi Liu, Rutao Wang, Tao Yin, Erhe Gao, Xinliang Ma, Ling Tao
Journal: Journal of the American College of Cardiology (2018)
The Frequency of Premature Coronary Artery Disease Identified on Coronary CT Angiography Among Patients Presenting With Chest Pain at a Single Institution
Authors: Ali M. Agha, Jean-Paul Bryant, Maria Marquez, Khurram Butt, Nicholas Feranec, William F. Sensakovic, Julie Pepe, Usman Siddiqui, Thomas J. Ward, Fiona Tissavirasingham, Jeremy R. Burt
Journal: JACC. Cardiovascular imaging (2018)