tbuckley/cabot-search huggingface dataset:
Evaluating an Asymptomatic Adnexal Cyst Found on Pelvic Ultrasonography
Authors: Deborah Levine
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Identification of the tumor specific antigens recognized by CTL from a patient with large cell carcinoma of lung cancer
Authors: Yoshika Nagata, Takeshi Hanagiri, Tetsuro Baba, Takashi Fukuyama, Makiko Mizukami, Tetsuya So, Yoshinobu Ichiki, Manabu Yasuda, Masakazu Sugaya, Hidetaka Uramoto, Takashi Yoshimatsu, Mitsuhiro Takenoyama, Tsunehiro Oyama, Kenji Sugio, Kosei Yasumoto
Journal: Cancer Research (2005)

5123  [Background] Lung cancer is one of the most common malignant disease and its incidence and mortality continue to increase worldwide The prognosis of advanced lung cancer was extremely poor in spite of standard therapies A large number of tumor specific antigens have been used in vaccination trials for cancer patients, however, only a small population of patients has shown evidence of tumor regression Our purpose of this study is to identify novel tumor antigen useful for immunotherapy of lung cancer patients [Methods and Results] We have established 21 lung cancer cell lines from 875 lung cancer specimens One of these cell lines, A904L was a stable cultured cell line derived from a patient (A904) with large cell carcinoma of the lung We established three different CTL clones from RLNLs (regional lymph node lymphocytes) of a patient A904 by a mixed lymphocyte-tumor cell culture Clone 1 and Clone 2 recognized autologous tumor cells (A904L), whereas they did not respond to autologous EBV-B and PHA-blastoid T cells A904L expressed HLA-A24, -B7, and -Cw7 with a loss of HLA haplotype Clone 1 recognized the tumor antigen restricted by HLA-A24 cDNA clone 214 was isolated by using a cDNA expression cloning method, and a 9-mer peptide was identified as the novel antigenic peptide which recognized by Clone 1 The coding gene revealed a splicing variant of known gene On the other hand, Clone 2 recognized the tumor antigen in the context of HLA-Cw7 The isolated cDNA clone was identical to the reported gene of which function was unknown To identify the antigens restricted by the lost HLA class I (HLA-B39), we established HLA-B39-reconstructed A904L variants (A904L-B39) Clone 3 was established from RLNLs by weekly stimulation with A904L-B39 Clone 3 lysed A904L-B39, but did not lyse parental A904L cDNA clone 301 was isolated as an antigen-coding gene, and an antigenic peptide was presented on the HLA-B39 molecule The antigen was reported to play a key role for cell cycle regulation [Discussion] Several tumor specific CTLs could be induced from RLNLs against single lung cancer cells RLNLs play a crucial role for tumor immune response Clone 1 and clone 2 recognized the tumor specific antigen in the context of remaining HLA alleles (HLA-A24, -Cw7), respectively Clone 3 responded to the antigen presented by reconstructed HLA class I molecule Tumor cells with a normal HLA class I expression may be eradicated by Clone 3 at an early stage of carcinogenesis, and only tumor cells with a haplotype loss could escape from an immune attack and develop into clinical cancer Identification of these antigens has a possibility to clarify the tumor escape mechanisms, and to improve more efficient peptide-vaccine immunotherapy
Institutional Conflicts of Interest and Public Trust
Authors: Francisco G. Cigarroa, Bettie Sue Masters, Dan Sharphorn
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 20116: The Impact of Atrial Fibrillation Type on the Risk of Thromboembolism, Mortality and Bleeding: A Systematic Review and Meta-analysis
Authors: Anand Ganesan, Derek Chew, Trent Hartshorne, Joseph B Selvanayagam, Philip Aylward, Prashanthan Sanders, Andrew D McGavigan
Journal: Circulation (2015)

Introduction: Thromboembolic risk stratification schemes and clinical guidelines for atrial fibrillation regard risk as independent of classification into paroxysmal (PAF) and nonparoxysmal atrial fibrillation (NPAF). The aim of the current study was to conduct a systematic review and meta-analysis evaluating the impact of AF type on thromboembolism, bleeding and mortality. Hypothesis: AF type would predict rates of thromebolism, mortality and bleeding. Methods: Pubmed was searched for randomized controlled trials, cohort studies, and case series reporting prospectively collected clinical outcomes stratified by AF type. The incidence of thromboembolism, mortality and bleeding was extracted. Results: AF clinical outcome data was extracted from 12 studies containing 99,996 patients. The pooled unadjusted risk ratio (RR) for thromboembolism in NPAF vs. PAF was RR 1.339 (95% CI: 1.140-1.644, P&lt;0.001). In studies providing estimates of thromboembolism risk adjusted for baseline clinical risk factors, the pooled adjusted hazard ratio (HR) in NPAF vs. PAF was HR 1.384 (95% CI, 1.191-1.608, P&lt;0.001). The pooled unadjusted risk ratio for all-cause mortality in NPAF vs. PAF was RR 1.462 (95% CI: 1.255-1.703 P&lt;0.001). The pooled adjusted HR for all-cause mortality in NPAF vs. PAF was HR 1.217 (95% CI: 1.085-1.365, P&lt;0.001. Rates of bleeding in NPAF and PAF were similar, unadjusted RR 1.00 (95% CI 0.919-1.087, P=0.994), pooled adjusted HR 1.025 (95% CI: 0.898-1.170, P=0.715). Conclusions: These data suggest a need for re-evaluation of the paradigm of thromboembolic risk equivalence between PAF and NPAF, and emphasize AF type as a powerful predictor of AF-related morbidity and mortality. Future studies exploring integration of AF type into thromboembolic risk models are needed.
Clinical and laboratory markers as predictors of time to treatment failure (TTF) and overall survival (OS) in patients (pts) with mucosal melanoma (MM)
Authors: F.J. Ros Montañá, I. Baraibar Argota, C. Ortiz Velez, J.F. Grau Béjar, G. Villacampa, V. Garcia-Patos, D. Bodet, C. Fernandez-Pulido, R. Dienstmann, E. Muñoz-Couselo
Journal: Annals of Oncology (2018)
Abstract 9789: Transient Elevation of Highly Sensitive Troponin T Levels in Patients With Documented Coronary Artery Disease Following Stress Myocardial Perfusion Imaging
Authors: Stefan P Pfeiffer, Teresa Schnabel, Wolfgang Höpfner, Christiane Saadé, Rainer Zimmermann, Hugo A Katus
Journal: Circulation (2014)

Introduction: Cardiac troponins are the preferred biomarkers of myocardial injury. More sensitive assays led to the detection of circulating troponins not only in myocardial infarction, but also in apparently healthy subjects after prolonged exercise. Hypothesis: In the era of highly sensitive troponin T (hs-TnT) tests we assesed the hypothesis that brief but intense exercise during diagnostic tests might cause elevated troponin levels in patients with stable coronary artery disease (CAD). Methods: Seventy-two patients (71% male, age 64±10 years) with documented CAD, LVEF &gt;45%, normal renal function and normal baseline hs-TnT levels (&lt;14 ng/l) underwent myocardial perfusion imaging (MPI, Tc-99m sestamibi) using bicycle stress test (n=19) or adenosine stimulation (n=55). Hs-TnT levels were detected immediately before and immediately after stress, and again after 4 hours and 24 hours. The extent of stress-induced myocardial ischemia was estimated from perfusion scores derived from single-photon emission computed tomography (SPECT) post stress and rest images. Significant reversible myocardial ischemia was prospectively defined as regional perfusion abnormality ≥10% of the left ventricular myocardium. Results: Transient elevations of hs-TnT levels above the normal limit occurred in 5/72 patients (7%) after diagnostic stress testing with a peak level at 4 hours after stress. Hs-TnT elevations were more common in patients with stress-induced myocardial ischemia (3/12, 25%) compared to patients without ischemia (2/60, 3%; p=0.038). However, no relation between peak hs-TnT levels and the extent of reversible myocardial ischemia was found (r=-0.16, n=72, p=NS). Furthermore, peak hs-TnT levels were similar with both types of stress (bicycle 6.6 [4.0 – 10.5] pg/l versus adenosine 5.1 [3.1 – 8.6] pg/l, median [IQR]). Conclusions: Transient hs-TnT elevations are quite common after diagnostic stress testing and occur more frequently in patients with documented reversible ischemia. No relation between peak hs-TnT levels and the extent of reversible myocardial ischemia at MPI was obtained. In conclusion this suggests that hs-TNT elevation during stress testing depends on other factors then those leading to SPECT-detected myocardial ischemia.
Improved in vitro cytotoxicity of vaccinia virus in colon cancer cells by expression of murine tumor necrosis factor-related apoptosis-inducing ligand and combination with chemotherapy
Authors: Mohammed F. Ziauddin, Zongsheng Guo, Petar Popovic, Maihgan Kavanagh, Mark E. O'Malley, Yong Lee, David L. Bartlett
Journal: Cancer Research (2006)

770  Vaccinia virus has properties that make it potentially useful as an anticancer agent. These properties include a rapid life cycle in the host cell cytoplasm, presence of promoters capable of driving high levels of protein production, efficient cell-to-cell spread, induction of tissue destruction, and a natural tumor tropism. Tumor selectivity has been increased by construction of recombinant vaccinia virus vectors either with deletion of the thymidine kinase (TK) gene alone, or with deletions of both the TK gene and vaccinia growth factor (VGF) gene. While these recombinant vectors themselves show promise as oncolytic viruses, we hypothesize that their effect can be enhanced by taking advantage of their strong promoters to drive expression of death ligands or immunostimulatory molecules. We have constructed a recombinant vaccinia virus with deletion of the thymidine kinase (TK) gene and with insertion of a gene for murine tumor necrosis factor-related apoptosis inducing ligand (mTRAIL). In this study, we compare the oncolytic activity of a TK-deleted vaccinia virus (VJS6) with that of the vaccinia virus expressing mTRAIL (vvmTRAIL) in the human colon cancer cell line DLD1. Given that several studies have shown synergy between chemotherapeutic agents and TRAIL, we evaluated the effects of combining oxaliplatin with the two viral constructs in DLD1 cells. Cultured DLD1 cells were treated with VJS6 and vvmTRAIL, either alone or in combination with oxaliplatin. mTRAIL expression was evaluated by flow cytometry. Cell viability and apoptosis were evaluated with MTS assay and Annexin V conjugated with phycoerythrin, respectively. The fraction of cultured DLD1 cells expressing mTRAIL reached a maximum level at 24 hours after infection with vvmTRAIL. When treated at a multiplicity of infection (MOI) of 0.5, more than 70% of cells expressed mTRAIL after 24 hours. This fraction increased to greater than 90% if apoptosis was inhibited using a pan-caspase inhibitor. The expression of mTRAIL increased the killing efficiency of the vaccinia virus. After treatment at an MOI of 1 for 72 hours, VJS6 caused less than 20% decrease in cell viability, whereas vvmTRAIL caused greater than 75% decrease in cell viability. Over 24 hours, vvmTRAIL at an MOI of 0.1 induced apoptosis in more than 25% of cultured cells, while VJS6 at the same MOI induced apoptosis in less than 10% of cells. The effect of the vvmTRAIL was enhanced by oxaliplatin, evidenced by reduction of the IC50 value of vvmTRAIL. These results demonstrate in an in vitro model that the anti-tumor effect of vaccinia virus can be enhanced by the expression of TRAIL. The tumoricidal effect can be further enhanced by oxaliplatin in a colon cancer cell line.
Afatinib in chemotherapy pre-treated EGFR mutation-positive NSCLC
Authors: S. Thongprasert, S.L. Geater, D. Clement, A. Abdelaziz, J. Reyes-Igama, D. Jovanovic, A. Alexandru, M. Schenker, V. Sriuranpong, P. Serwatowski, S. Suresh, A. Cseh, R. Gaafar
Journal: Annals of Oncology (2018)
Axicabtagene Ciloleucel (Axi-cel) CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma: Real World Experience
Authors: Loretta J. Nastoupil, Michael D. Jain, Jay Y. Spiegel, Armin Ghobadi, Yi Lin, Saurabh Dahiya, Matthew A. Lunning, Lazaros J. Lekakis, Patrick M. Reagan, Olalekan O. Oluwole, Joseph P. McGuirk, Abhinav Deol, Alison R. Sehgal, Andre Goy, Brian T. Hill, Charalambos Andreadis, Javier Munoz, Jason R. Westin, Julio C. Chavez, Amanda F Cashen, Nora N Bennani, Aaron P. Rapoport, Julie M. Vose, David B. Miklos, Sattva S. Neelapu, Frederick L. Locke
Journal: Blood (2018)
Abiraterone acetate (AA) in patients with metastatic castration-resistant prostate cancer (MCRPC) after docetaxel chemotherapy: Multicentric experience of Anatolian Society of Medical Oncology.
Authors: Umut Demirci, Utku Oflazoglu, Hilmi Kodaz, Aydin Ciltas, Umut Kefeli, Murat Akyol, Banu Ozturk, Caglayan Geredeli, Mehmet Metin Seker, Sener Cihan, Didem Tastekin, Alper Sevinc, Muhammed Bulent Akinci, Mukremin Uysal, Burcu Yapar Taskoylu, Ayse Ocak Duran, Omer Kamil Yazici, Aziz Karaoglu, Mustafa Benekli, Suleyman Buyukberber
Journal: Journal of Clinical Oncology (2014)

e16094 Background: We evaluated the efficiency and safety of AA in patients with MCRPC after docetaxel chemotherapy. Methods: Between April 2011 and January 2014, we retrospectively evaluated survival outcomes and toxicities of 103 patients with MCRPC after docetaxel chemotherapy who were treated with AA (1000 mg, orally once daily) plus prednisone (5 mg, orally twice daily). Results: Median age was 67 (45-85) and 46% of the patients had at least one comorbid diseases. Median initial diagnosis of PSA was 61.7 ng/dl (3-3,000) and 86.4% of the patients had more than Gleason score 6. Radical prostatectomy and definitive radiotherapy were performed 19.4% and 32% of the patients, respectively. Secondary hormonal manipulation was performed 25.2% of the patients. The 77.7% of the patients progressed while on treatment of the docetaxel. Before the AA, median docetaxel cycles and dose were 7 (1-40) and 900 mg (75-5,400 mg), respectively. Initial of the AA, ECOG performance status 2 and 3 were in 35 patients (34%) and median PSA was 100 ng/dl (0-5371 ng/dl). Metastatic sites were as follow; only bone (n= 52, 50.5%), bone and soft tissue/ lymph node (n= 6, 5.8%) and visceral metastases (n=45, 43.7%). Toxic deaths were in five (4.9%) and dose reduction was applied in 12.6% of the patients. Clinical benefit was 44.6%, median progression free survival and overall survival were 211.86 day (169.23-260.48) and 486.67 day (380.12-593.21), respectively. Most common adverse events were anemia (31.1%), nausea and vomiting (20.4%), elevation of transaminases (12.7%). Conclusions: AA is the effective agent with tolerable safety profile in patients with MRCPC.
Abstract 20040: Risk Assessment in Pregnant Women With Congenital Heart Disease
Authors: Leah A Goldberg, Lacey P Gleason, Emily S Ruckdeschel, Tanmay Bhamare, David Drajpuch, Adi Hirshberg, Sara L Partington, Rachel Rogers, Sindhu K Srinivas, Natalie Stokes, Lynda Tobin, Lisa D Levine, Yuli Y Kim
Journal: Circulation (2016)

Introduction: As more women with congenital heart disease (CHD) survive into their childbearing years, clinicians are faced with assessing pregnancy risk. Published risk stratification schemes have...
Fulfilling States’ Duty to Evaluate Medicaid Waivers
Authors: Kristen Underhill, Atheendar Venkataramani, Kevin G. Volpp
Journal: New England Journal of Medicine (2018)

States seeking to implement experimental policies in their Medicaid programs must apply for a Section 1115 waiver. Every waiver project is an experiment, and robust evaluations would allow such experiments to yield useful lessons for Medicaid program design.
Nasal allergen-neutralizing IgG4 antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy
Authors: Mohamed H. Shamji, Jasper Kappen, Hisham Abubakar-Waziri, Jinjin Zhang, Esther Steveling, Shelley Watchman, Lubna Kouser, Aarif Eifan, Amy Switzer, Gilda Varricchi, Gianni Marone, Natália C. Couto-Francisco, Moises Calderon, Stephen R. Durham
Journal: Journal of Allergy and Clinical Immunology (2018)
Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer
Authors: David A. Bader, Sean M. Hartig, Vasanta Putluri, Christopher Foley, Mark P. Hamilton, Eric A. Smith, Pradip K. Saha, Anil Panigrahi, Christopher Walker, Lin Zong, Heidi Martini-Stoica, Rui Chen, Kimal Rajapakshe, Cristian Coarfa, Arun Sreekumar, Nicholas Mitsiades, James A. Bankson, Michael M. Ittmann, Bert W. O’Malley, Nagireddy Putluri, Sean E. McGuire
Journal: Nature Metabolism (2018)
Trends in Opioid Prescription in Children and Adolescents in a Commercially Insured Population in the United States, 2004-2017
Authors: Joshua J. Gagne, Mengdong He, Brian T. Bateman
Journal: JAMA Pediatrics (2018)

More than half of the participants reported that their abuser had or could easily access a gun, highlighting the importance of legislation to prevent IPV abusers from legally obtaining or maintaining firearms as a means to decrease risk of IPH.Although limited by lack of pediatric patient data, our findings highlight the significant risk for IPH among these families.Children often experience unintended effects of IPH. 3 Pediatric health care settings offer a unique opportunity to provide IPV resources.Parents experiencing IPV may seek health care for their children when they would not see a clinician for their own health care needs.Children are also a motivating factor for seeking help for IPV. 7 It is critical that efforts to address IPV in pediatric settings provide opportunities for all families to access IPV resources, as well as optimize safety practices around screening and response to disclosure.Future studies should examine the risk of IPH among more diverse populations and explore use of the LAP to facilitate resource provision and clinical management.
Wide Complex Tachycardia and Syncope in a Middle-aged Woman
Authors: Laith A. Derbas, Omair K. Yousuf, Faraz Kureshi
Journal: JAMA Cardiology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
The Fully Human Anti-CD47 Antibody SRF231 Has Dual-Mechanism Antitumor Activity Against Chronic Lymphocytic Leukemia (CLL) Cells and Increases the Activity of Both Rituximab and Venetoclax
Authors: Rebecca Valentin, Marisa O. Peluso, Timothy Z. Lehmberg, Ammar Adam, Li Zhang, Caroline M. Armet, Jennifer L. Guerriero, Benjamin H. Lee, Vito J. Palombella, Pamela M. Holland, Alison M. Paterson, Matthew S. Davids
Journal: Blood (2018)
Reducing Protections for Noncitizen Children — Exacerbating Harm and Trauma
Authors: Ryan Matlow, Daryn Reicherter
Journal: New England Journal of Medicine (2018)

Interview with Dr. Ryan Matlow on proposed changes to U.S. regulations on standards of care for noncitizen children. (08:36)Download As part of an ongoing effort to deter immigrants from attempting to enter the United States, a new government proposal would permit the detention of noncitizen children and their families for indefinite periods in facilities without appropriate and independent monitoring.
Abstract 20162: Improved Determination of 3D Myocardial Strain using Existing 320-Slice CT Data for the Detection of Left Ventricular Myocardial Fibrosis in Hypertrophic Cardiomyopathy
Authors: Nobusada Funabashi, Hiroyuki Takaoka, Koya Ozawa, Yoshio Kobayashi
Journal: Circulation (2017)

Introduction: A new three dimensional (3D) CT strain analysis to evaluate the left ventricular myocardium (LVM) using existing volumetric CT data obtained from retrospective ECG gating acquisition ...