tbuckley/cabot-search huggingface dataset:
Cancer patient interest and perceptions of lifestyle behavior programs
Authors: L. Eng, S. Liu, Q. Zhang, D. Farzanfar, S. Yeung, C.M. Brown, W. Xu, D. Howell, D.P. Goldstein, J.M. Jones, P. Selby, M.E. Giuliani, G. Liu
Journal: Annals of Oncology (2017)
Abstract 85: Interactions Between Cardiac Myosin Binding Protein C and Actin Contribute to the Regulation of Cardiac Contraction
Authors: Sabine J van Dijk, Kristina Bezold Kooiker, Samantha P Harris
Journal: Circulation Research (2016)

Cardiac myosin binding protein C (cMyBP-C) is a regulatory muscle protein that is essential for proper cardiac contraction, and mutations in cMyBP-C are commonly associated with hypertrophic cardiomyopathy. cMyBP-C not only interacts with myosin, but with actin as well. In vitro studies have demonstrated that multiple functions of cMyBP-C could readily be explained by an interaction between cMyBP-C and actin, but the in vivo significance of cMyBP-C binding to either myosin or actin is not well understood. Here we created transgenic mice with a single point mutation (L348P) in a key binding domain of cMyBP-C that enhances the binding affinity of cMyBP-C for actin in vitro (Bezold et al , JBC 2013) to gain insights into the relevance of cMyBP-C binding to actin in working hearts. Echocardiograms from 3 month old male L348P-Tg mice (N=23) and non-transgenic (nTg, N=17) controls were used to assess systolic and diastolic function. Results showed significantly prolonged isovolumetric relaxation time (L348P-Tg: 18.5±0.6 vs nTg: 10.2±0.3 ms) and slower movement of the mitral valve annulus (E’: -17.2±1.5 vs -32.2±1.6 and A’: -9.1±1.7 vs -17.6±1.0 mm/s, p&lt;0.05), accompanied by slower inflow of blood into the left ventricle (reduced E and A, prolonged mitral valve deceleration time). Pressure-volume measurements showed significantly reduced rates of pressure decay in L348P-Tg mice (Tau Glantz: 39.1±2.6 vs 12.7±0.9 ms) and an increased end-diastolic pressure volume relationship (0.13±0.02 vs 0.07±0.01). We challenged mice with acute beta-adrenergic stimulation (isoprenaline injection) to determine whether the L348P mutation affected contractile reserve. Isoprenaline had little effect on diastolic parameters, but revealed systolic dysfunction in L348P-Tg mice as evident from a blunted increase in contraction (e.g. fractional shortening after isoprenaline: 38.5±1.3 vs 44.2±1.7%). Taken together our results show for the first time that interactions between cMyBP-C and actin are relevant for functioning of the whole heart. Increasing the cMyBP-C-actin interaction by the L348P mutation caused increased stiffness of the left ventricle, slowed relaxation and diastolic dysfunction. Results also suggested that the L348P mutation reduces contractile reserve.
Stasis Mapping Using Ultrasound
Authors: Pablo Martinez-Legazpi, Lorenzo Rossini, Candelas Pérez del Villar, Yolanda Benito, Carolina Devesa-Cordero, Raquel Yotti, Antonia Delgado-Montero, Ana Gonzalez-Mansilla, Andrew M. Kahn, Francisco Fernandez-Avilés, Juan C. del Álamo, Javier Bermejo
Journal: JACC. Cardiovascular imaging (2017)
Abstract 15821: Safety and Efficacy of Non-invasive Ventilation During Exercise Training in Patients With Acute Heart Failure. A Randomized Prospective Controlled Study
Authors: Mayron F Oliveira, Rita L Santos, Vanessa M Mendez, Priscila A Sperandio, Iracema I Umeda, Edileide B Correa, Almir S Ferraz
Journal: Circulation (2015)

Background: Exercise training (ET) is well established to improve functional capacity and quality of life in patients (pts) with chronic heart failure. However, the ET benefits in acute heart failure (AHF) are unknown. Purpose: We aimed to study the safety and efficacy of ET alone or combined with non-invasive ventilation (NIV) compared to standard medical treatment in hospitalized pts with AHF. Methods: Twenty-nine pts with AHF (68% ischemic), 56±7 years, left ventricle ejection fraction of 25±5%, NTproBNP of 2456±730, 6-minute walk test distance (6MWD = 225±39meters) were randomized into 3 groups: ET + NIV with sub therapeutic positive airway pressure (PAP) (ET,n=9), ET + NIV set to 14 of inspiratory and 8 cmH2O of expiratory PAP, respectively (EV,n=11) and standard treatment (CO,n=9). The ET and EV groups performed a daily session of unloaded exercise on cycle ergometer for 20 min or tolerance limit, for 8 consecutives days. In EV and ET, oxygen pulse saturation (SpO2), heart rate (HR), respiratory rate (RR), blood pressure (BP), blood lactate were measured at baseline (D1), during exercise, and at day 10 (D10). Serious adverse events (death or worsening heart failure) were also assessed on D10. Results: Length of hospital stay was shorter in EV group (17±10 days) compared to ET (23±8 days) and CO (39±15 days) (p&lt;0,05). There were more serious adverse events in CO (66,6%) compared to both EV and ET (15%). Dobutamine use at D10 was less frequent in EV (18,2%) and ET (22,2%) groups than in CO (33,3%) (p&lt;0.05). There was a marked improvement in Δ6MWD between D1 and D10 in EV (Δ127±72 meters), though increase in Δ6MWD was also seen in ET (Δ72±26 meters) and CO (Δ41±19meters), p&lt;0,05. The EV group also showed higher endurance and lower peak HR at end-exercise than ET at D10 (128±10 vs. 92±8 min and 73±12 vs. 104±25 bpm, respectively; p&lt;0,05). There was a similar reduction in NTproBNP levels but no differences were found in BP, SpO2, RR and blood lactate. Conclusion: Aerobic exercise in AHF was safe, reduced length of hospital stay and need for inotropics at D10. NIV + ET increased exercise endurance with lower cardiovascular stress.
Um surto de Campylobacter jejuni associado com o consumo de frango, Copenhague, 2005
Authors: A Mazick, S Ethelberg, E Møller Nielsen, K Mølbak, M Lisby
Journal: Eurosurveillance (2006)

Em maio-junho de 2005, um surto de infeccoes intestinais declarou-se em empregados de empresas em Copenhague. Os casos provinham de sete das oito companhias que recebiam a comida do mesmo produtor. As amostras de fezes de treis pacientes de duas companhias eram positivas para Campylobacter jejuni. Foi levado a cabo um estudo de cohorte retrospectivo entre os empregados frequentando a cantina nas tres companhias mais importantes, com o objetivo de identificar a fonte do surto e prevenir a sua disseminacao. As informacoes sobre a doenca, os dias de frequentacao da cantina e os alimentos consumidos foram recolhidas usando um questionario auto-administrado. A cozinha do produtor foi investigada e tomaram-se amostras de comida. Dos 348 empregados entrevistados, 295 (85%) preencheram o questionario. Entre as 247 pessoas que comiam na cantina, identificaram-se 79 casos, seja uma taxa de attaque (TA) de 32%. Comer na cantina no dia 25 de maio foi associado com a doenca (TA 75/204, RR=3,2 ; 95%IC 1,3-8,2). So o consumo de salada de frango, no mesmo dia, foi associado com a infeccao (TA=43/97, RR=2,3 ; 95%IC 1,3-4,1). Os empregados de cozinha indiquaram a possibilidade duma contaminacao cruzada entre o frango cru e a salada de frango antes de preparar. Describimos aqui o primeiro surto de Campylobacter conhecido associado a frango contaminado na Dinamarca. Provavelmente a manipulacao dos alimentos contribuiu para a transmissao da doenca. As poucas amostras positivas neste surto sugerem uma sub-estimacao geral (por um factor 20) dos casos adultos pelo sistema de notificacao de laboratorio.
Long-term response to second-line afatinib in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): Analysis of the LUX-Head & Neck 1 (LHN1) trial
Authors: J-P. Machiels, G. de Castro, L. de Souza Viana, R. Galiulin, M. Tahara, U.R. Nicolau, C. Le Tourneau, K. Okami, V. Vladimirov, A. Izmailov, K. Hoermann, L. Licitra, R. Haddad, E. Cohen, N. Dupuis, J. Love, E. Zografos, E. Ehrnrooth, J. Fayette
Journal: Annals of Oncology (2017)
Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis
Authors: Sachin Hajarnis, Matanel Yheskel, Darren Williams, Thomas Brefort, Bob Glaudemans, Huguette Debaix, Michel Baum, Olivier Devuyst, Vishal Patel
Journal: Journal of the American Society of Nephrology (2017)

Export microRNAs (miRNAs) are sequence-specific inhibitors of post-transcriptional gene expression. The physiologic function of these noncoding RNAs in postnatal renal tubules still remains unclear. Surprisingly, they appear to be dispensable for mammalian proximal tubule (PT) function. Here, we examined the effects of miRNA suppression in collecting ducts (CDs). To conclusively evaluate the role of miRNAs, we generated three mouse models with CD-specific inactivation of key miRNA pathway genes Dicer, Dgcr8, and the entire Argonaute gene family (Ago1, 2, 3, and 4). Characterization of these three mouse models revealed that inhibition of miRNAs in CDs spontaneously evokes a renal tubule injury–like response, which culminates in progressive tubulointerstitial fibrosis (TIF) and renal failure. Global miRNA profiling of microdissected renal tubules showed that miRNAs exhibit segmental distribution along the nephron and CDs. In particular, the expression of miR-200c is nearly 70-fold higher in CDs compared with PTs. Accordingly, miR-200s are downregulated in Dicer-KO CDs, its direct target genes Zeb1, Zeb2, and Snail2 are upregulated, and miRNA-depleted CDs undergo partial epithelial-to-mesenchymal transition (EMT). Thus, miRNAs are essential for CD homeostasis. Downregulation of CD-enriched miRNAs and the subsequent induction of partial EMT may be a new mechanism for TIF progression.
Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR–Cas9 genome editing
Authors: Bruna S. Paulsen, Pankaj K. Mandal, Richard L. Frock, Baris Boyraz, Rachita Yadav, Srigokul Upadhyayula, Paula Gutierrez-Martinez, Wataru Ebina, Anders Fasth, Tomas Kirchhausen, Michael E. Talkowski, Suneet Agarwal, Frederick W. Alt, Derrick J. Rossi
Journal: Nature Biomedical Engineering (2017)
Um surto regional de S. Typhimurium na Dinamarca : identificação da fonte por tipagem MLVA
Authors: M Torpdahl, G Sørensen, S Ethelberg, G Sandø, K Kammelgard, L Jannok Porsbo
Journal: Eurosurveillance (2006)

Na Dinamarca, o sistema nacional de vigilância microbiologica das infeccoes entericas, inclue a sub-tipagem de todos os isolamentos de S. Typhimurium por lisotipagem, tipagem por antibiograma e electroforese em campo pulsado (PFGE). 
Por entanto, para certos lisotipos, a capacidade discriminatoria do PFGE e insuficiente, e torna-se as vezes impossivel de separar os isolamentos associados dos nao associados. Por este motivo, desde 2004, o metodo de sub-tipagem MLVA (multiple locus variable number of tandem repeats analysis) foi applicado para a vigilância dos isolamentos de S. Typhimurium. Um surto de 26 casos de S. Typhimurium foi identificado assim em maio e junho de 2005. Os isolamentos eram totalmente sensiveis a todos antibioticos e tinham um dos lisotipos mais frequentes na Dinamarca (DT12) e o mesmo perfil PFGE. Os resultados da tipagem mostraram uma semelhanca perfeita entre os isolamentos humanos e um isolamento provindo de uma pocilga e do matadouro correspondente, situados na mesma regiao. Os outros isolamentos de DT12 analizados que tinham o mesmo perfil em PFGE, revelaram tipos MLVA differentes. A hipotese que essaa pocilga seja a fonte das infeccoes humanas foi reforcada por informacoes sobre os pacientes. A venda da carne desse criatorio foi prohibida no 29 de Junho. A analise por MLVA pode contribuir efficazmente para a vigilância e as investigacoes de surtos de S. Typhimurium. Sem este metodo de tipagem, nao era possivel detecter o tal surto, nem descobrir a fonte.
Exosomal ECM1 protein expression in plasma from the tumor-draining vein (mesenteric vein) and time to relapse in colon cancer patients
Authors: S. Santasusagna, A. Navarro, I. Moreno, R. Ibeas, F. Martinez, J.J. Castellano, C. Muñoz, J. Canals, S. Morales, R. Hernandez, J. Moreno, M. Monzo
Journal: Annals of Oncology (2017)
Analysis of response rate with anti-PD1/PDL1 antibodies in advanced solid tumors: A meta-analysis of randomized clinical trials (RCT).
Authors: Alberto Carretero-González, David Lora, Ismael Ghanem, Jon Zugazagoitia, Daniel Castellano, Juan Manuel Sepúlveda, Jose A. Lopez-Martin, Guillermo de Velasco, Luis G. Paz-Ares
Journal: Journal of Clinical Oncology (2017)

e14576 Background: Anti-PD1/PDL1 antibodies (mAbs) have been shown to increase overall survival (OS) compared to standard of care (SOC) in solid tumors (mainly melanoma and lung cancer). Despite the efficacy in OS, a significant proportion of patients (pts) will have progressive disease (PD) as best response. Therefore, we have conducted a meta-analysis to study the rates of response comparing these novel antibodies with SOC (chemotherapy or targeted therapy). Methods: We conducted a search of the published RCT in MEDLINE and EMBASE analyzing anti-PD1/PDL1mAbs monotherapy compared to SOC. All studies used RECIST v1.1. Relative risk (RR) with 95% confidence interval (CI) of response rates between groups was estimated. Clinical heterogeneity was explored via subgroup analyses for location of primary tumor, number of previous treatment lines and selected population by PDL1 expression. Results: Eleven studies accounting for 6,396 pts were included (anti-PD1/PDL1 mAbs: 3,333 pts; SOC: 3,063 pts[2,637 pts: chemotherapy, 426 pts: targeted therapy]). Adjusted response rates were (N ,%): Complete Response (CR)(50/3035, 1.65%), Partial Response (PR)(558/3035, 18.39%), Stable Disease (SD)(585/2345, 24.95%) and PD (896/2345, 38.21%); and CR (7/2769, 0.25%), PR (241/2769, 8.70%), SD (744/2083, 35.72%) and PD (744/2083, 35.72%) with anti-PD1/PDL1 mAbs and SOC, respectively. Anti-PD1/PDL1 mAbs improved CR rate (RR 4.70) and PR rate (RR 2.38). There were no differences in the PD rate between groups (RR 1.09; table 1). Subgroup analyses showed a significant improvement in clinical benefit with anti-PD1/PDL1 mAbs for melanoma (RR 1.5; 1.42-1.91 95% CI) and pts treated in the first line setting (RR 1.57; 1.27-1.95 95%CI). Conclusions: Anti-PD1/PDL1 mAbs increase overall response rate compared to SOC without an increase in PD rate. Melanoma and pts treated in first line setting seem to have greater benefit with anti-PD1/PDL1 mAbs. [Table: see text]
GW28-e0647 Effects of the advanced glycation end-products modified low density lipoprotein on pro-osteogenic and pro-fibrotic responses in human aortic valve interstitial cells
Authors: Qingchun Zeng, Xi Yang, Guandi Wu, Jiayi Xian, Jun Li, Die Zhu, Ruxia Liang, Jiaying Li, Wenyan Lai, Dingli Xu
Journal: Journal of the American College of Cardiology (2017)
A randomized phase II study of ipilimumab (IPI) with carboplatin and paclitaxel (CP) in patients with unresectable stage III or IV metastatic melanoma (MM).
Authors: Rahima Jamal, Karl Belanger, Jennifer Elisabeth Friedmann, Jean-Pierre M. Ayoub, Eftihia Cocolakis, Shirin Kazemi, Jeanne Dionne, Caroline Lambert, HB Le, Leon Van Kempen, Alan Spatz, Rejean Lapointe, Wilson H. Miller
Journal: Journal of Clinical Oncology (2014)

9066 Background: MM has been one of the most treatment-resistant human malignancies. Recently, IPI, a fully human anti-CTLA4 monoclonal antibody has been widely approved for patients (pts) with MM on the basis of increased overall survival (OS). CP is one of few therapies available to pts with BRAF wild type MM that is progressing rapidly. We hypothesized that cytoreduction by CP might both provide time for IPI response, as well as expose immune cells to tumor antigens. In addition to safety and anti-tumor activity, immune biomarker studies were performed. Methods: Thirty pts with no prior treatment or one BRAF targeted regimen were randomized in a 1:2 ratio to either concurrent (arm A) or sequential (arm B) CP (AUC6 + 175mg/m2 x 5) with IPI (3mg/kg x 4) given every 3 weeks either concurrently or delayed by one week. Tumor assessments were conducted at week 8, 16 and 24. Results: We enrolled 24 cutaneous, 2 mucosal, 3 ocular and 1 unknown primary melanoma. Median age was 55 years and 6 of 8 BRAF mutated pts previously received vemurafenib. Twenty-five pts (83%) received all 5 cycles of CP while 28 pts (93%) completed IPI induction. Two pts died prior to week 16 of disease progression, while 3 patients discontinued CP because of toxicity. Overall median follow-up was 24 weeks (8-24). Response rates (RR) and disease control rates (DCR) for 14 evaluable patients at 24 weeks were 21.4% and 42.9% by mWHO, and 35.7% and 64.3% by irRC, respectively. There were no treatment-related deaths on trial. Grade 3-4 AEs regardless of causality were seen in 63% of pts. CP-related Grade 3-4 AEs were found in 47% of pts in the form of hepatotoxity, electrolyte imbalances, myelosuppression and infections. Grade 3-4 anemia occurred in 3 pts while thrombocytopenia occurred in 2 pts. The rate of febrile neutropenia was 7% (2/30). Seventeen per cent (5/30) of patients received steroids for an immune-related (ir) AE: 2 pts with Grade 3 colitis, 2 pts with Grade 2 endocrinopathy, and 1 pt with Grade 2 rash. Conclusions: Safety results suggest manageable toxicity when CP is added to IPI, with most patients completing the full course of treatment. Updated ORR, DCR, 6 month OS, and immune biomarker studies will be presented. Clinical trial information: NCT01676649.
A Multifaceted Approach Is Needed to Respond to the Plight of Bioethicists in Accessing Literature
Authors: Michael O. S. Afolabi, Stephen O. Sodeke
Journal: The American Journal of Bioethics (2017)

This article refers to:A Question of Social Justice: How Policies of Profit Negate Engagement of Developing World Bioethicists and Undermine Global Bioethics
Advances in fMRI Real-Time Neurofeedback
Authors: Takeo Watanabe, Yuka Sasaki, Kazuhisa Shibata, Mitsuo Kawato
Journal: Trends in Cognitive Sciences (2017)

Functional magnetic resonance imaging (fMRI) neurofeedback is a type of biofeedback in which real-time online fMRI signals are used to self-regulate brain function. Since its advent in 2003 significant progress has been made in fMRI neurofeedback techniques. Specifically, the use of implicit protocols, external rewards, multivariate analysis, and connectivity analysis has allowed neuroscientists to explore a possible causal involvement of modified brain activity in modified behavior. These techniques have also been integrated into groundbreaking new neurofeedback technologies, specifically decoded neurofeedback (DecNef) and functional connectivity-based neurofeedback (FCNef). By modulating neural activity and behavior, DecNef and FCNef have substantially advanced both basic and clinical research.
Association Between Immigrant Status and End-of-Life Care in Ontario, Canada
Authors: Christopher J. Yarnell, Longdi Fu, Doug Manuel, Peter Tanuseputro, Therese Stukel, Ruxandra Pinto, Damon C. Scales, Andreas Laupacis, Robert A. Fowler
Journal: JAMA (2017)

<h3>Importance</h3> People who immigrate face unique health literacy, communication, and system navigation challenges, and they may have diverse preferences that influence end-of-life care. <h3>Objective</h3> To examine end-of-life care provided to immigrants to Canada in the last 6 months of their life. <h3>Design, Setting, and Participants</h3> This population-based cohort study (April 1, 2004, to March 31, 2015) included 967 013 decedents in Ontario, Canada, using validated linkages between health and immigration databases to identify immigrant (since 1985) and long-standing resident cohorts. <h3>Exposures</h3> All decedents who immigrated to Canada between 1985 and 2015 were classified as recent immigrants, with subgroup analyses assessing the association of time since immigration, and region of birth, with end-of-life care. <h3>Main Outcomes and Measures</h3> Location of death and intensity of care received in the last 6 months of life. Analysis included modified Poisson regression with generalized estimating equations, adjusting for age, sex, socioeconomic position, causes of death, urban and rural residence, and preexisting comorbidities. <h3>Results</h3> Among 967 013 decedents of whom 47 514 (5%) immigrated since 1985, sex, socioeconomic status, urban (vs rural) residence, and causes of death were similar, while long-standing residents were older than immigrant decedents (median [interquartile range] age, 75 [58-84] vs 80 [68-87] years). Recent immigrant decedents were overall more likely to die in intensive care (15.6% vs 10.0%; difference, 5.6%; 95% CI, 5.2%-5.9%) after adjusting for differences in age, sex, income, geography, and cause of death (relative risk, 1.30; 95% CI, 1.27-1.32). In their last 6 months of life, recent immigrant decedents experienced more intensive care admissions (24.9% vs 19.2%; difference, 5.7%; 95% CI, 5.3%-6.1%), hospital admissions (72.1% vs 68.2%; difference, 3.9%; 95% CI, 3.5%-4.3%), mechanical ventilation (21.5% vs 13.6%; difference, 7.9%; 95% CI, 7.5%-8.3%), dialysis (5.5% vs 3.4%; difference, 2.1%; 95% CI, 1.9%-2.3%), percutaneous feeding tube placement (5.5% vs 3.0%; difference, 2.5%; 95% CI, 2.3%-2.8%), and tracheostomy (2.3% vs 1.1%; difference, 1.2%; 95% CI, 1.1%-1.4%). Relative risk of dying in intensive care for recent immigrants compared with long-standing residents varied according to recent immigrant region of birth from 0.84 (95% CI, 0.74-0.95) among those born in Northern and Western Europe to 1.96 (95% CI, 1.89-2.05) among those born in South Asia. <h3>Conclusions and Relevance</h3> Among decedents in Ontario, Canada, recent immigrants were significantly more likely to receive aggressive care and to die in an intensive care unit compared with other residents. Further research is needed to understand the mechanisms behind this association.
The ability of avitinib to penetrate the blood brain barrier and its control of intra-/extra- cranial disease in patients of non-small cell lung cancer (NSCLC) harboring EGFR T790M mutation.
Authors: Hanping Wang, Li Zhang, Xin Zheng, Xiaotong Zhang, Xiaoyan Si, Mengzhao Wang
Journal: Journal of Clinical Oncology (2017)

e20613 Background: Avitinib is an oral, potent, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor selective for T790M resistance mutations. We report the safety, the intracranial/extracranial efficacy, and the blood brain barrier (BBB) penetration rate of Avitinib in non-small cell lung cancer(NSCLC) patients with EGFR T790m mutation. The data come from Peking Union Medical College hospital-a single center of the Phase I, open-label, multicenter study (NCT02330367). Methods: NSCLC Patients with acquired EGFR T790m (+) were enrolled. Patients were orally administered with dose escalating from 150 mg to 300 mg twice daily for 28-continuous-day cycles until disease progression. Blood (2mL) and cerebrospinal fluid (CSF) samples (2ml) were collected for concentration analysis on day 29 in available patients with brain metastases (BM). Tumor response was assessed on day 29 and then every 8 weeks. Results: Sixteen patients were included. Nine patients had asymptomatic BM. The most frequent adverse events were the elevated hepatic transaminases (10/16, 62.5%) and diarrhea (5/16, 31.3%), Most were mild and reversible. 9 Patients (56.3%) achieved Partial Response (PR), 6 (37.5%) achieved Stable Disease (SD). Median Progress Free Survival (PFS) was 253 days (95%CI: 154.8-339.2). Of the 8 evaluable BM patients, intracranial PFS were shorter than extracranial in only two patients. The blood and CSF analysis of 6 BM patients showed the BBB penetration rate were 0.046%-0.146% (Table). Conclusions: Avitinib is well tolerated and efficacious in EGFR T790m(+) NSCLC patients. Its concentration in CSF is low, and the penetrability of BBB is weak. But it still showed a good control of BM. Further studies are proceeding. Clinical trial information: NCT02330367. [Table: see text]
GW28-e0214 Clinical and genetic investigation for long QT syndrome type 3: Meta-Analysis
Authors: Kun Li, Jing Yang, Fei She, Yuanwei Liu, Rong He, Wenjia Guo, Yu Qiao, Tingting Lv, Jie Zhou, Wei Sun, Hua Li, Ping Zhang
Journal: Journal of the American College of Cardiology (2017)