tbuckley/cabot-search huggingface dataset:
Effects of the Selective Sodium-Glucose Cotransporter 2 Inhibitor Empagliflozin on Vascular Function and Central Hemodynamics in Patients With Type 2 Diabetes Mellitus
Authors: Kristina Striepe, Agnes Jumar, Christian Ott, Marina V. Karg, Markus P. Schneider, Dennis Kannenkeril, Roland E. Schmieder
Journal: Circulation (2017)
SAT0213 Low dose il-2 restores decreased absolute number of regulatory t cells and imbalance between th17 and regulatory t cells in patients with rheumatoid arthritis
Authors: R Jia, X Li, C Wang, C Gao
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> A therapeutic revolution in the past decade is still a considerable unmet need in the treatment of rheumatoid arthritis (RA). On the other hand, dysfunction of regulatory T cells (Tregs) has been considered to be a pivotal cause of RA and correction of this dysfunction to be a potential RA therapy<sup>1</sup>. However, abnormalities of Tregs in patients with RA were reported controversially in previous studies<sup>2</sup>, in which only proportion was measured and Tregs were defined using different protein markers. <h3>Objectives</h3> In this study, we measured both absolute numbers and proportions of CD4+CD25+Foxp3+ Tregs in peripheral blood of RA patients and investigated the effects of low-dose recombinant human IL-2 (rhIL-2) on Tregs and CD4+ effector T cell subsets in patients with RA. <h3>Methods</h3> Both absolute numbers and proportions of Treg and Th17 cells in peripheral blood, defined as the CD4+CD25+FOXp3+T or CD4+IL-17 + T cell population, were examined by flow cytometry in 342 patients with RA with different 28-joint Disease Activities (DAS28), including 75 who had never received disease-modifying antirheumatic drugs (DMARD) and 151 who were receiving or had received DMARD. Among these patients, 112 consented at enrollment to receive rhIL-2 treatment. Before and after treatment, the Th17 and Treg cells in peripheral blood were analyzed by flow cytometry. <h3>Results</h3> The absolute count of Treg cells in patients with RA was significantly low compared with that of healthy controls (P&lt;0.05), but the absolute count of Th17 cell was no different between RA and healthy controls. After the course of rhIL-2 treatment, there was a significant increase in the absolute count of Th17 and Treg cells in the CD4+ T cell population (P&lt;0.01), but Th17/Treg was significantly low after the treatment. <h3>Conclusions</h3> The data suggest that, besides propotion, the decrease of Treg cell number, defined as the CD4+CD25+FOXp3+population, may contribute to the pathogenesis of RA. Over the treatment of rhIL-2, there was a more significant increase in the absolute count of Treg cells than that of Th17, and consequently restore the balance of Th17/Treg. <h3>References</h3> Miyara M, Ito Y, Sakaguchi S. TREG-cell therapies for autoimmune rheumatic diseases. Nature reviews Rheumatology 2014;10:543–51. Morita T, Shima Y, Wing JB, Sakaguchi S, Ogata A, Kumanogoh A. The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis. PloS one 2016;11:e0162306. <h3>Disclosure of Interest</h3> None declared
SAT0692 Predictors and persistence of unacceptable pain during the first year of rheumatoid arthritis in sweden
Authors: H Westerlind, ME Schelin, R Altawil, L Klareskog, L Alfredsson, J Lampa
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Pain is a dominant symptom in rheumatoid arthritis (RA). <h3>Objectives</h3> Investigate unacceptable pain (VAS-pain ≥40) during the first year of the disease and whether it can be predicted from baseline disease characteristics. <h3>Methods</h3> The cohort included all incident RA cases from the Swedish population-based case-control Epidemiological Investigation of Rheumatoid Arthritis study (EIRA), who also were in the Swedish Rheumatology Register. Unacceptable pain was defined as scoring 40 mm or above on the pain visual analog scale (VAS) (i.e. not reaching the patient acceptable symptom state (PASS) (1)), and the proportion of patients going in and out of PASS was traced over the first year. Association between baseline parameters, divided into quartiles, and unacceptable pain at one year was assessed using modified Poisson regression and expressed as risk ratios with 95% confidence intervals (95% CI), adjusted for sex and age at diagnosis. <h3>Results</h3> A total of 2808 patients were included in the study and 33.8% of the patients presented with PASS (i.e.VAS pain below 40) at inclusion. If a patient had PASS at any given visit, there was over 70% chance that the patient remained in PASS at the following visit. The most common PASS pattern (25.6%), was to present with unacceptable pain, reach PASS at the 3 month visit, and then remain in PASS. However, one year after diagnosis, only two thirds of the patients had PASS. Higher disability (measured as HAQ) at baseline was significantly and independently associated with an increased risk for unacceptable pain at one year (for the highest quartile of HAQ; RR=1.97 [95% CI:1.60–2.42]). Also high tender joint count at baseline was associated with an increased risk for unacceptable pain; RR=1.40 [95% CI: 1.18–1.65] for the highest quartile, whereas high swollen joint count at baseline was associated with a decreased risk; RR=0.79 [95% CI: 0.66–0.95] for the highest quartile. <h3>Conclusions</h3> The results highlight the need for efficient pain treatment strategies early in the disease. <h3>References</h3> Tubach F, Ravaud P, Martin-Mola E, Awada H, Bellamy N, Bombardier C, et al. Minimum clinically important improvement and patient acceptable symptom state in pain and function in rheumatoid arthritis, ankylosing spondylitis, chronic back pain, hand osteoarthritis, and hip and knee osteoarthritis: Results from a prospective multina. Arthritis Care Res (Hoboken) 2012;64:1699–1707. <h3>Acknowledgements</h3> We would like to acknowledge the EIRA study group and the EIRA data collectors. <h3>Disclosure of Interest</h3> None declared
Further Studies of the Liver Catalase Activity of Tumor-Bearing Animals
Authors: Jesse P. Greenstein
Journal: JNCI Journal of the National Cancer Institute (1943)

Journal Article Further Studies of the Liver Catalase Activity of Tumor-Bearing Animals Get access Jesse P. Greenstein Jesse P. Greenstein senior biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 3, Issue 4, February 1943, Pages 397–404, https://doi.org/10.1093/jnci/3.4.397 Published: 01 February 1943
SAT0662 Evaluation of anti-double stranded dna antibodies in the monitoring of systemic lupus erythematosus
Authors: T Dervieux, T O'Malley, J Conklin, C Ibarra, C Bentow, MA Aure, M Mahler
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic autoimmune rheumatic disease characterized by the production of pathogenic autoantibodies. Amongst these antibodies, those directed to dsDNA are routinely used to monitor disease activity and are components of the SELENA-SLEDAI index to score severity of SLE disease. Because the predictive value of anti-dsDNA is dependent on the sensitivity and robustness of the assays used, the choice of anti-dsDNA is crucial in the clinical laboratory and clinical research setting. <h3>Objectives</h3> The objective was to compare four anti-dsDNA assays for their performance characteristics of SLE disease activity. <h3>Methods</h3> A cohort of 36 subjects with active SLE presenting with classical complement activation were enrolled and followed monthly for 1 year. At each study visit blood was collected, serum isolated and frozen until analysis. A total of 371 specimens were collected. Disease activity was scored on the day of each study visit according to the SELENA-SLEDAI method excluding anti-dsDNA or complement components (non-serological [ns] SELENA-SLEDAI). All specimens were tested using four different anti-dsDNA kits; QUANTA Lite, QUANTA Flash, a high Avidity anti-dsDNA ELISA, and the <i>Crithidia luciliae</i> indirect immunofluorescence assay (CLIFT) (Inova Diagnostics, San Diego, CA). Study visits presenting with inactive disease (ns-SELENA- SLEDAI score=0) were compared to those presenting with active disease (ns-SELENA- SLEDAI&gt;0). The longitudinal data were analyzed using linear mixed effect modeling with the ns-SELENA-SLEDAI as dependent variable and the anti-dsDNA titers as fixed effect predictors. Marginal R<sup>2</sup> was calculated for each assay. <h3>Results</h3> At enrollment the sensitivity of the QUANTA Lite and High Avidity anti-dsDNA both reached 64%; whereas anti-dsDNA positivity was 83% by QUANTA Flash and reached 96% by CLIFT. Study visits with active disease presented with several fold higher anti-dsDNA titers than those with inactive disease status (Table 1). Linear mixed effect modeling indicated that the decrease in ns-SELENA-SLEDAI scores were associated with significant reduction in titers of all three anti-dsDNA kits (Table 2). QUANTA Flash yielded highest marginal R<sup>2</sup> (0.112) (Table 2). <h3>Conclusions</h3> These preliminary data indicate that anti-dsDNA antibodies determined by QUANTA Flash have value in monitoring SLE disease activity. <h3>Disclosure of Interest</h3> T. Dervieux: None declared, T. O9Malley: None declared, J. Conklin: None declared, C. Ibarra: None declared, C. Bentow Employee of: Inova Diagnostics, M. A. Aure Employee of: Inova Diagnostics, M. Mahler Employee of: Inova Diagnostics
AB0340 Clinical efficacy of statins in patients with rheumatoid arthritis
Authors: L Mikulets, T Ilashchuk
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Cardiovascular disease (CVD) is a major cause of mortality in patients with rheumatoid arthritis (RA). In the literature there are conflicting data on the use of statins in patients with RA, indicating a lack of attention to the issue of prevention of CVD in this category of patients. <h3>Objectives</h3> The aim of the study was to improve the efficiency of the treatment of rheumatoid arthritis by including to the basic treatment rosuvastatin. <h3>Methods</h3> The study included 43 patients with RA. A survey conducted by the protocol patients (DAS28 index, visual analog scale (VAS), morning stiffness). The study of lipid metabolism included: determining the level of total cholesterol (total cholesterol), HDL cholesterol (HDL) and low density (LDL), atherogenic index (AI), triglycerides (TG). Total cardiovascular risk assessment was performed using a table SCORE. Surveyed patients divided into groups: primary (n=20) (basic therapy and rosuvastatin, 10 mg 1 time per day) and comparison (n=23) (basic therapy that included methotrexate, non-steroidal anti-inflammatory drugs, glucocorticoids in medium therapeutic doses). <h3>Results</h3> As a result of the treatment found that patients with a primary and group comparison, there was a positive dynamics of clinical indicators of inflammatory activity (DAS28, VAS, morning stiffness). In the study group experienced a significant decrease (p&lt;0.05) at the same time as in the comparison group had a tendency to decrease. Noted a reduction parameters: CRP (Δ<sub>1</sub>37% main group and the comparison group Δ<sub>2</sub>21%), ESR (Δ<sub>1</sub>39% and Δ<sub>2</sub>26% respectively). Also noted the changes in the lipid profile. Significantly decreased in the study group performance total cholesterol (Δ<sub>1</sub>31% versus Δ<sub>2</sub>15%), LDL cholesterol (Δ<sub>1</sub>19% against Δ<sub>2</sub>8%) and AI (Δ<sub>1</sub>29% and Δ<sub>2</sub>16% respectively). <h3>Conclusions</h3> Inclusion in the complex therapy of patients with RA statins contributes to a significant reduction in total cholesterol, LDL cholesterol, and positively affects the activity of the process, reducing the levels of acute phase proteins. Additional indications for the purpose of statins have high activity process and late onset. The use of statins in RA, given their lipid-lowering and anti-inflammatory effects, may be an effective means for the successful prevention of cardiovascular complications. <h3>Disclosure of Interest</h3> None declared
AB0808 Comparing the effects of physical therapy and non-steroidal anti-inflammatory treatment on sleep quality, quality of life and clinical status in knee osteoarthritis
Authors: M Sezgin, E Yeşildal, H Ankaralı, G Sahin
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Objectives</h3> We aimed to compare the effectiveness of physical therapy (PT) and non-steroidal anti-inflammatory drug (NSAID) therapy on sleep quality, quality of life and clinical status in patients with knee osteoarthritis (OA). <h3>Methods</h3> Demographic characteristics of the participants were recorded. MOS sleep scale, Nottingham Health Profile (NHP) and Western Ontario ve McMaster Universities Osteoarthritis Index (WOMAC) were used to evaluate sleep quality, quality of life and clinical status of patients before and after the treatment.All patients were divided into two groups as PT (57 patients) and NSAID (43) groups. The patients in the drug group were administered oral dexketoprofen (50 mg/day, for two week) and the patients in the PT group were administered five times a week, total 15 seances hot-pack, ultrasound and transcutaneous electrical nerve stimulation therapy. <h3>Results</h3> Demographic characteristics, MOS sleep scale and NHP were similar at baseline in both groups (p&gt;0.05). WOMAC pain, stiffness, and physical function scores before treatment were significantly poorer in the PT group than the NSAID group (P&lt;0.05). There were statistically significant improvements on the MOS sleep scale (except snoring subscore, p=0.05, table 1), NHP (except social isolation, p=0.209) and and WOMAC pain, stiffness, physical function and total scores of both groups after the treatments (p&lt;0.05). Improvement was also similar when both groups were compared after the treatment (p&gt;0.05). After the two treatment, significantly side effect was not observed. <h3>Conclusions</h3> PT and NSAID therapy has good effectiveness on sleep quality, quality of life and clinical status in knee OA. <h3>References</h3> Wilcox S, Brenes GA, Levine D, et al. Factors related to sleep disturbance in older adults experiencing knee pain or knee pain with radiographic evidence of knee osteoarthritis. J Am Geriatr Soc 2000; 48:1241. Vivien CA, Priscilla SA, Christian G. Sleep and rheumatologic disorders. Sleep medicine reviews 2008;12: 211–228. Dieppe PA, Lohmander LS. Pathogenesis and management of pain in osteoarthritis. Lancet 2005; 365:965–973.54. Fielden JM, Gander PH, Horne JG, et al. An assessment of sleep disturbance in patients before and after total hip arthroplasty. J Arthroplasty 2003; 18:371–6. Hunter DJ, Lo GH. The management of osteoarthritis: an overwiev and call to appropriate conservative treatment. Rheum Dis Clin N Am 2008; 34:689–712.99. Hays RD, Martin SA, Sesti AM, Spritzer KL. Psychometric properties of the Medical Outcomes Study Sleep measure. Sleep Med 2005; 6:41–44. <h3>Disclosure of Interest</h3> None declared
THU0276 Interferon-related chemokine IP-10 is a potential biomarker in incomplete systemic lupus erythematosus
Authors: W Lambers, K De Leeuw, M Jonkman, H Bootsma, J Westra
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Incomplete SLE (iSLE) is the designation of patients who display symptoms that are typical for SLE, but with insufficient criteria to fulfil the diagnosis. Unfortunately, predictive biomarkers for SLE development are lacking. Increased IFN-type I production is an important factor in the pathogenesis of SLE. Interferon-regulated chemokines therefore could possibly be useful as biomarkers for disease progression to SLE. Candidate biomarkers IFN-γ induced protein 10 (IP-10) and monocyte chemo attractant protein (MCP-1) have shown to be increased in SLE and to correlate with disease activity. <h3>Objectives</h3> To determine possible candidate biomarkers IFN-γ induced protein 10 (IP-10) and monocyte chemo attractant protein (MCP-1) in patients with iSLE. <h3>Methods</h3> Serum samples were collected of 30 iSLE patients, 29 SLE patients, and 17 ANA-negative patients with histologically proven cutaneous lupus erythematosus (ANCLE). Outcomes were compared with 25 age- and gender-matched controls (CTL) and 31 rheumatoid arthritis (RA) patients as disease control group. Levels of IP-10 and MCP-1 were measured using ELISA. <h3>Results</h3> IP-10 was significantly increased in SLE and RA patients compared with CTL and ANCLE. IP-10 levels were increased in 23% of iSLE patients. These patients had higher SLE disease activity index (SLEDAI) and more frequently decreased C3 level and joint involvement compared to those with normal IP-10 levels. Regarding MCP-1 levels, no significant differences were found between any of the groups and no correlations with clinical markers was found. <h3>Conclusions</h3> Levels of IP-10, but not MCP-1, might be useful as a predictive biomarker for progression to SLE in patients with iSLE, although future prospective longitudinal analyses are needed to confirm this hypothesis. <h3>Disclosure of Interest</h3> None declared
THU0727-HPR Blended interventions for fatigue self-management: is this the way patients and professionals like to go?
Authors: C Bode, E Taal, H Vonkeman, F Ben Allouch, K Hohl
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Blended care, the integration of online and face-to-face care, promises to combine the best of two worlds. <h3>Objectives</h3> To explore the attitudes and needs concerning blended care of two key stakeholders: health professionals and patients. <h3>Methods</h3> Rheumatologists (8) and specialized nurses (5) were recruited in a Dutch hospital and patients with an inflammatory rheumatic disease (10) were recruited via flyers in hospitals and patient organizations in Germany. A semi-structured interview scheme was used to explore knowledge, experiences, needs and perceived (dis)advantages of a blended care format for fatigue self-management. Transcribed verbal data were coded with hierarchical coding schemes. <h3>Results</h3> Perspective of professionals: Blended care matches needs for psychosocial interventions in medical settings, has a patient-friendly and flexible format, reflects the active role of patients and can easily be imbedded in standard care. Reported barriers were low education and skills in technology use in patients, the lack of proven and safe interventions and costs for development/ implementation. Patient perspective: Patients expected better communication, time saving and improvement of autonomy in self-management. They were concerned about loss of personal contact and in general, patients were very critical regarding online activities, privacy risks and guaranteed quality of eHealth products. <h3>Conclusions</h3> Health professionals and patients differ in their attitudes towards blended care. Professionals are better informed and have a more positive attitude, whereas patients9 attitudes towards blended care are mainly driven by their reservations towards the reliability and safety of the internet in general. Results will be discussed on the background of attitudes towards eHealth in different countries. <h3>Disclosure of Interest</h3> None declared
IT glitch forces GPs to cancel shifts
Authors: Gareth Iacobucci
Journal: BMJ (2017)

Locum doctors are being forced to cancel scheduled clinics at GP surgeries because of an IT glitch that has led to their “erroneous removal” from the national performers list, GP leaders have warned.

The problem has caused staffing problems at practices and meant that locum doctors are missing out on income, said the BMA. It first reported the problem to NHS England and the private company Capita, which manages the list, last year, but has recently noticed a worsening of the situation.

GPs wishing to practise in England must be registered on the national performers list to prove that they are suitably qualified, their training is …
AB0807 Validity of the quadriceps angle measurement in patients with varus knee osteoarthritis: compare the goniometric and photogrammetry method to radiography method
Authors: M Erduran, M Eymir, B Ünver, ND Demirkıran
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Various measurement methods have been defined to assess the alignment of the lower extremities. The Q-angle measurement is reported to be associated with knee injury and patellofemoral dysfunction. The Q-angle has been assessed using radiography scans, goniometer and photogrammetry methods in supine and standing positions. The radiography method is accepted to be the most accurate and valid measurement technique in measurement the Q-angle. But as a result of being expensive and time-consuming, this invasive method is not mostly preferred in research and clinics. The goniometric measurement of Q-angle is practical because it is simple, requires inexpensive equipment (only a goniometer), and can be applied in a short time. Photogrammetry measurement technique is also an advantageous method for reducing measurement errors caused by goniometers and reduction of investigator errors. <h3>Objectives</h3> The aim of the present study, was to compare the clinical assessment of the Q-angle (goniometric and photogrammetric measurement methods) to a radiological assessment using radiograph (criterion validity) in patients with varus knee osteoarthritis. <h3>Methods</h3> The study group consisted of 15 (median age 68.6±11.9 years) patients with unilateral and bilateral varus knee osteoarthritis. Q-angle measurements were assessed on both lower extremities with three different goniometric methods (goniometric measurement method in standing position with quadriceps muscle relaxed; goniometric measurement method in supine position with quadriceps muscle relaxed; and contracted) using a 360° universal goniometer. After the goniometric measurements, photographs were taken with quadriceps muscle relaxed in standing position. For radiographic assessment, we used patients9 lower extremity scanograms, which had been taken to determine the diagnosis and treatment from the Computer Patient Archiving System database. <h3>Results</h3> There was a good correlation between the radiographic assessment and photogrammetric measurement (r=0.623, p&lt;0.001). Also a good correlation was observed between radiographic assessment and goniometric measurement (in standing position with quadriceps muscle relaxed; in supine position with quadriceps muscle relaxed; and contracted) (r=0.676, p&lt;0.001, r=0.616, p&lt;0.001, r=0.676, p&lt;0.001, respectively). <h3>Conclusions</h3> According to our result, the photogrammetric measurement and the goniometric measurement appear to be valid alternatives to the radiographic measurement for determining the Q-angle. These alternative measures might be used by clinicians and researchers to measure the Q-angle of patients with varus knee osteoarthritis in orthopaedic clinics. <h3>Disclosure of Interest</h3> None declared