tbuckley/cabot-search huggingface dataset:
AB0906 Pyogenic septic arthritis: is there a difference when germ is not identified?
Authors: H Sahli, M Sahli, R Tekaya, O Saidane, R Khalfallah, I Mahmoud, L Abdelmoula
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Pyogenic septic arthritis (PSA), defined by the presence of living microorganisms in the affected joint, is a therapeutic emergency. Germ isolation is a primordial step in the diagnostic and therapeutic approach. <h3>Objectives</h3> The aim of this study was to study the differences between PSA with positive and negative bacteriology. <h3>Methods</h3> This is a retrospective study which included medical records of patients treated for PSA in a rheumatology department over seventeen years. The epidemioclinical and paraclinical data were recorded. We used the SPSS 11.5 for the statistical analysis to compare patients with (group 1) and without an isolated causative agent (group 2). <h3>Results</h3> We evaluated 49 patients with a diagnosis of PSA. They were 26 (53.1%) men and 23 (46.9%) women. The average age was 55+/-18.7 years (ranging from 15 to 95 years). Comorbidities were observed in 31 (63.3%) patients. The onset of symptoms was acute in 37 (75.5%) patients and progressive in 12 (24.5%) patients. The most common symptoms were joint pain and stiffness (100%) and functional impotence (87.8%). All patients were treated with double or triple antibiotics. Among the studied patients, 27 (55.1%) had negative culture results. Statistical analysis used to compare cases with an isolated pathogen to those cases without an isolated pathogen, noted female predominance in group 2 but there was no statistically significant difference (p=0.252). Patients in group 1 and group 2 had a comparable mean age (p=0.08). Patients in both groups had comparable risk factors for PSA (p=0.549). Acute onset was more common in group 2 (51.4% versus 48.6%) but without a significant difference (p=0.507). Biological inflammatory syndrome was more frequent in group 2 but with no statistically significant difference (p=0.235). The study of the appearance of the synovial fluid did not demonstrate a statistically significant difference between the two groups (p=0.125). The abnormalities of standard x-rays were similar in both groups (45.2% in group 1 versus 54.8% in group 2, (p=1)). The statistical study of all other variables didn9t show differences between the two groups. <h3>Conclusions</h3> PSA was not associated with major differences if the germ was or not isolated. <h3>Disclosure of Interest</h3> None declared
Differential Regulation Of Neutrophil (pmn) Survival By The Prolyl Hydroxylase Enzymes Phd2 And Phd3
Authors: Walmsley, Thompson Aar., H Marriott, L Williams, A Lewis, I Sabroe, D Dockrell, C T Taylor, E Chilvers, C Pugh, P Ratcliffe, P H Maxwell, M Mazzone, P Carmeliet, Whyte Mkb.
Journal: American Journal of Respiratory and Critical Care Medicine (2013)
AB1099 Counselling on family planning and contraception, and pregnancy outcome in women with rheumatic diseases: a national survey of 398 patient-reported questionnaires from 24 rheumatology centers
Authors: MG Lazzaroni, F Dall'Ara, L Andreoli, C Carini, M Rodrigues, R Reggia, E Bartoloni-Bocci, R Gerli, CB Chighizola, M Gerosa, PL Meroni, L Sinigaglia, P Conigliaro, R Perricone, A Corrado, FP Cantatore, S D'Angelo, I Olivieri, M Favaro, A Doria, A Ruffatti, E Generali, C Selmi, M Meroni, M Cutolo, M Padovan, M Govoni, G Pazzola, C Salvarani, S Peccatori, G Paolazzi, I Prevete, GD Sebastiani, G Minisola, A Brucato, V Ramoni, R Caporali, C Montecucco, C Tani, M Mosca, M Trevisani, N Malavolta, M Vadacca, A Afeltra, E Vivaldelli, A Maier, E Baldissera, E Visalli, R Foti, L Zuliani, A Gabrielli, N Romeo, A Tincani
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Rheumatic diseases (RD) predominantly affect young women during reproductive age. Pregnancy, contraception and family planning (FP) are crucial for the quality of life of these patients. <h3>Objectives</h3> We aimed to investigate 9women9s health9 through a self-reported questionnaire. Answers from patients with connective tissue diseases (CTD) vs chronic arthritis (CA) were compared. <h3>Methods</h3> 24 centres distributed the questionnaire (65 multiple-choice and 12 open-answer questions) to women with RD (18–45years) regularly attending their outpatient clinics. <h3>Results</h3> Answers were collected from 249 CTD vs 149 CA patients. Their desire to have children was influenced by RD in 40% of cases: half of them reduced the number of children they wanted (Table 1). 39% CA vs 29% CTD were afraid of being mother because of disability. 24% CTD vs. 18% CA had at least one miscarriage; 21% CTD vs. 2% CA had more than one. 31% CTD and 34% CA were never asked about their desire to have children. 61% CTD vs 70% CA received counselling about contraception, given by a gynaecologist (G) (58% vs 64%), rheumatologist (R) (22% vs 14%) or both (7% vs 9%). 60% in both groups received a counselling before pregnancy: 34% vs 39% from R and G, 14% vs 22% by R. This positively changed family planning in 64% vs 59%. We created a Knowledge Index (based on the average of the normalized performed scores on 6 key questions for different sections): 55% CTD patients vs 44% CA had a medium-high score. A higher score directly correlated with the desire to became pregnant and with a multidisciplinary counselling. <h3>Conclusions</h3> This survey suggested that CTD have a major impact on FP and family size, possibly mediated by the increased rate of miscarriages as compared to CA. Concerns about reproductive issues could be positively overcome by adequate counselling. Rheumatologists should implement the discussion about FP and the compatibility of drugs with pregnancy in the management of young women with RD, especially those with CTD for whom contraception and pregnancy have particular implications. <h3>Acknowledgements</h3> Statistical analysis supported by an unrestricted grant by UCB Pharma Thanks to Patients9 Associations and Participants <h3>Disclosure of Interest</h3> None declared
SP0079 Pathologies across the tissues in psa
Authors: R Lories
Journal: Annals of the Rheumatic Diseases (2017)

The psoriatic disease concept includes the skin disease psoriasis and joint disease psoriatic arthritis. Increasingly, prevalent comorbidities such as obesity and cardiovascular disease are considered to be an integral part of the psoriatic disease concept in many patients. Within this disease concept, accumulating evidence indicates molecular and cellular cross talk between affected organs and tissues. Skin inflammation affects the bone; nail disease is associated with specific types of arthritis; inflammation links to cardiovascular disease; skin or joint disease may contribute to depression. Novel therapeutic strategies are reaching psoriatic disease patients as never before. Their global impact could be envisioned from a holistic perspective, optimizing the strategy chosen as determined by the active molecular and cellular network that triggers and sustains disease. Thus, linking the joints with the skin and other organs involved is proposed as an entry point towards personalized medicine in a complex disease. <h3>Disclosure of Interest</h3> R. Lories Grant/research support from: Celgene, Boehringer-Ingelheim, UCB, Consultant for: Janssen, Celgene, Novartis, Pfizer, UCB, Abbvie, Speakers bureau: Janssen, Celgene, Novartis, Pfizer, Merck, UCB, Abbvie
Private patients treated by rogue breast surgeon will be compensated under £37m fund
Authors: Clare Dyer
Journal: BMJ (2017)

A new £37m (€41m; $49m) fund has been agreed to compensate around 750 private patients of the rogue breast surgeon Ian Paterson.

The fund will settle claims against Spire Healthcare, which ran the private Little Aston and Parkway hospitals, and against two codefendants: Paterson himself, and the Heart of England NHS Trust, where he worked as an NHS consultant surgeon. The case had been due to go to the High Court for hearing next month, and the wording of a formal court order will still have to be approved by the court.1

The NHS trust settled on the basis that it referred some patients to Paterson …
FRI0532 Dual energy x-ray absorptiometry testing in women with breast cancer initiating therapy with aromatase inhibitors reduces subsequent fracture risk
Authors: MA Ursani, M Suarez-Almazor, M Yang, H-F Lu, H Zhao, L Elting
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Estrogen receptor positive breast cancer is commonly treated with aromatase inhibitors (AI). A well-known adverse effect of this therapy is osteoporosis and related bone fractures. National guidelines have promoted the use of dual energy X-ray absorptiometry (DXA) for screening purposes. <h3>Objectives</h3> To evaluate the association between use of DXA among women with breast cancer treated with AI enrolled in Medicare, and subsequent fracture risk. <h3>Methods</h3> Retrospective cohort study using the Texas Cancer Registry (TCR) and the National Cancer Institute9s Surveillance, Epidemiology and End Results (SEER) data linked with Medicare claims. To help estimate the likelihood of performing a DXA, a multivariable logistic regression model was used. Covariates of age, ethnicity, stage, residence area, and socioeconomic variables were controlled for the analyses. The outcome variable a DXA claim within 12 months after the initiation of the AI therapy. Cox regression model to evaluate time to first fracture after initiation of AI. <h3>Results</h3> The total number of cases within the SEER-Medicare database was 15,350 and in the TCR 4,532. Women aged between 66–74 years and Non-Hispanic white were more likely to get DXA than were Hispanic and Non-Hispanic Black. In TCR, 2714 patients did not get treatment for osteoporosis in the first 12 months after AI therapy initiation. 2989 patients did not receive treatment for osteoporosis within 12 months of obtaining their first DXA scan. 1330 patients who did not undergo DXA were not treated for osteoporosis; and 1384 patients who underwent DXA got treated for osteoporosis. The duration of AI treatment was negatively associated with the risk of fracture. Women who received DXA scan showed 11% lower risk of fracture than those who were not scanned (HR 0.89 (0.83, 0.94). <h3>Conclusions</h3> National guidelines suggest to obtain a DXA and start bisphosphonate therapy in female breast cancer patients who are treated with AI therapy. Our data suggests that the majority of women in the TCR and SEER database were not treated for osteoporosis within the first 12 months after initiation of AI therapy. Women who received DXA scan showed a lower risk of fracture than those who were not scanned. <h3>References</h3> National guidelines suggest to obtain a DXA and start bisphosphonate therapy in female breast cancer patients who are treated with AI therapy. Our data suggests that the majority of women in the TCR and SEER database were not treated for osteoporosis within the first 12 months after initiation of AI therapy. Women who received DXA scan showed a lower risk of fracture than those who were not scanned. <h3>Disclosure of Interest</h3> None declared
AB0361 Body composition and physical activity in patients with rheumatoid arthritis (AR)
Authors: S Manrique-Arija, N Mena-Vazquez, M Rojas-Giménez, C Fuego, S Abad-Sanchez, I Ureña-Garnica, C Domic, FG Jiménez-Núñez, MC Ordoñez-Cañizares, R Caparros-Ruiz, L Cano-Garcia, A Belmonte, B Panero-Lamothe, A Fernandez-Nebro
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Objectives</h3> To describe the body composition and physical activity of patients with RA <h3>Methods</h3> <i>Design:</i> Observational case-control study. <i>Population:</i> 31 consecutive RA-patients (ACR/EULAR 2010 criteria) selected from a prospective inception cohort (diagnosis of RA between 2005 and 2012),and 31 sex and age-matched voluntary controls.<i>Protocol:</i> We included 62 subjects who were assessed using dual-body X-ray absorptiometry (DEXA) for the assessment of body composition at study entry. Data on clinical activity were also collected from the onset of the disease.The level of physical activity was assessed according to the abbreviated protocol of the International Physical Activity Questionnaire (IPAQ). <i>Main outcome:</i> Fat mass index (FMI) and fat free mass index (FFMI).FMI was defined as fat mass (kg)/ height (m<sup>2</sup>) and FFMI as lean mass (kg)/height (m<sup>2</sup>).<i>Secondary outcome:</i> description of the anthropometric parameters:BMI (body mass index),waist-hip index. <i>Variables:</i> Demographic, treatment, clinical-analytical variables: Disease Activity Score of 28 joints (DAS28-ESR), Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI);Anti–cyclic citrullinated peptide (ACPA), Rheumatoid factor (RF),Health Assessment Questionnaire (HAQ)and erosions.BMI was categorized according to the OMS classification. Waist- hip index (central obesity&gt;1 for men and&gt;0.8 for women). <i>Statistical analysis:</i> Descriptive and paired T-test or ranks test and Wilcoxon signed rank,as required <h3>Results</h3> We included 62 subjects,31 RA (50%) and 31 controls (50%).The mean duration of the disease of RA patients was 84.4 months. With a DAS28 mean of 3.04 (0.8), mean HAQ of 0.77 (0.6). The majority presented erosions (64.5%) RF (83.9%) and ACPA (77.4%) positive. Differences in clinical and densitometric anthropometric parameters between cases and controls are shown in Table 1. Significant differences were observed in the proportion of overweight subjects between cases and controls (p=0.03). A higher percentage of controls had moderate to high physical activity compared with the patients (65.5% vs 34.8%). The majority of patients with RApatients had low physical activity (74.2%).These had a mean (SD) of HAQ higher than patients with moderate-high physical activity [1.2 (0.9) vs 0.66 (0.6); p=0.09].Finally, patients performing moderate-high physical activity had less inflammatory activity than those performing low physical activity,with a DAS28 mean of 2.69 (0.7) vs 3.08 (0.9) ;p=0.308, respectively <h3>Conclusions</h3> Patients with RA compared to controls show more overweight and less physical activity <h3>Disclosure of Interest</h3> None declared
SAT0316 Angii involvement in lung endothelial dysfunction and pah development in psgl-1 deficient female mice
Authors: R González-Tajuelo, M la Fuente-Fernández de, D Morales-Cano, B Barreira, J Silván, C Gamallo, S Castañeda, E Vicente-Rabaneda, F Pérez-Vizcaíno, Ά Cogolludo, LJ Jiménez-Borreguero, A Urzainqui
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Pulmonary arterial hypertension (PAH) is a rare disease whose etiopathogenesis is poorly understood, and existing treatments are neither curative nor sufficient for stopping disease progression [1]. PAH is one of the major complications of connective tissue diseases, and 7–15% of patients with systemic sclerosis (SSc) develop PAH [2]. Mice deficient for the leukocytic receptor P-selectin glycoprotein ligand-1 (<i>PSGL-1</i><sup>-/-</sup>) spontaneously develop a SSc-like autoimmune syndrome with ageing [3]. <h3>Objectives</h3> To check whether <i>PSGL</i><sup>-/-</sup> mice may develop PAH and which mechanisms might be implicated in the initiation and progression of the disease. <h3>Methods</h3> Vascular remodeling was assessed by immunohistochemistry on lung sections of WT and <i>PSGL-1</i><sup>-/-</sup> C57BL/6 mice. Doppler pulse echochardiography was used to evaluate pulmonary artery flow acceleration time/ ejection time (TPV/ET) ratio. Isolated pulmonary artery rings were incubated with KCL, serotonin or acetylcholine and responses were registrated with a wire myograph coupled to an isometric force transducer. Angiotensin II lung concentration was quantified by ELISA. ACE, ACE2, AT1R and AT2R expression was evaluated by western blot. Expression levels of the NO-sensing probe DAR-4M AM and IFN-γ were measured by flow cytometry. <h3>Results</h3> <i>PSGL-1</i><sup>-/-</sup> mice presented vascular remodeling of distal lung blood vessels. Aged <i>PSGL-1</i><sup>-/-</sup> females showed reduced flow TPV/ET ratio in the pulmonary artery and RV remodeling, indicating PAH. Moreover, pulmonary arterial rings from aged <i>PSGL-1</i><sup>-/-</sup> females presented increased vasoconstriction response to KCL and reduced vasodilation response to acetylcholine. Importantly, NO production by lung EC was reduced in aged <i>PSGL-1</i><sup>-/-</sup> females. Expression of AT2R was reduced in lungs of <i>PSGL-1</i><sup>-/-</sup> females from a young age. With ageing, the levels of angiotensin II and the percentages of IFN-γ-producing interstitial macrophages, T and B lymphocytes were increased in PSGL-1<sup>-/-</sup> females. <h3>Conclusions</h3> Together, these studies implicate leukocyte-endothelium interactions for the maintenance of vascular homeostasis and protection against PAH in PSGL-1 deficient female mice. <h3>References</h3> Montani et al. Orphanet Journal of Rare Diseases. 2013;8(97). Tedford et al. Circ Heart Fail. 2013;6(5)953–63. Pérez-Frías et al. Arthritis Rheumatol. 2014;66(11):3178–89. <h3>Acknowledgements</h3> We want to thank Ana Vanesa Alonso and Lorena Flores from the Unit of Advanced Imaging of the CNIC for their crucial support in echocardiography performance. <h3>Disclosure of Interest</h3> None declared
THU0366 Gastrointestinal infections in patients with spondyloarthritis treated with anti-tnf drugs: results of gisea register
Authors: F Atzeni, V Panetta, M Sebastiani, F Salaffi, A Carletto, R Foti, F Iannone, G Elisa, M Govoni, A Marchesoni, EG Favalli, R Gorla, R Ramonda, P Sarzi-Puttini, G Ferraccioli, G Lapadula
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Tumour necrosis factor (TNF) plays a pivotal role in controlling intracellular of bacterial infection. The BSR Biologics Register (BSRBR) has reported an increase in the occurrence of listeria and salmonella infections in anti-TNF-treated rheumatoid arthritis patients in comparison with those patients treated with non-biological DMARDs. <h3>Objectives</h3> The aim of this study was to determine the incidence of gastrointestinal infection in the anti-TNF-treated spondyloarthritis (SpA) patients in the GISEA registry, and identify the factors associated with its development. <h3>Methods</h3> The prospective GISEA registry was designed to collect real-world clinical data concerning patients with RA or SpA treated with biological drugs. The baseline information includes demographics, disease duration, HAQ-DI, DAS-28, BASDAI, BASFI and BASMI scores, steroid use, smoking history and comorbidities. <h3>Results</h3> Of the 3321 anti-TNF-treated SpA patients in the registry (1731 males, 52.2%; mean age 47±13 years; median disease duration three years, interquartile range [IQR] 0–8), 1065 (32%) were treated with infliximab (IFN), 1052 (32%) with adalimumab (ADA), and 1204 (36%) with etanercept (ETN). Two thousand, one hundred and five patients (63.4%) had a median of one comorbidity (IQR 0–2], the most frequent being hypertension (701), thyroid diseases (281), diabetes mellitus (207), cardiopathy (189), and osteoporosis (145). In combination with the biological drug, 919 patients (27.7%) received steroids and 2451 (79.9%) at least one DMARD. The median follow-up was three months (IQR 1–2 years). Twenty-two patients 0.7% experienced bacterial gastrointestinal infections, the most frequent being due to listeria, klebsilla and salmonella. The crude incidence rate was 2.5 per 1000 patient-years (95% CI 1.6–3.7). Univariate analysis showed that female gender (OR 3.9, 95% CI 1.5–10.0; p=0.004) and comorbidities (OR 3.4, 95% CI 1.0–3.5; p=0.049) were associated with a high risk of gastrointestinal infections, and that the use of IFN rather than ETN and ADA (p=0.712 and p=0.238) was not associated with a higher risk of gastrointestinal infections. Furthermore, univariate models showed that age (p=0.738), disease duration p=0.090, previous DMARDs (p=0.616), and HAQ (p=0.674) and BASFI (scores p=0.850) were not statistically significant predictors of gastrointestinal infections. <h3>Conclusions</h3> The incidence rate of gastrointestinal infections in SpA patients treated with anti-TNF drugs is not increased. Being female and having comorbidities are predictive factors of gastrointestinal infections. <h3>Disclosure of Interest</h3> None declared
OP0163-PARE Invigorating the principle of participatory research in germany - setup of a training course for patient representatives
Authors: J Clausen
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Patient participation in research projects is important because it enhances the legitimacy of research projects and facilitates the implementation of research results after completion of the respective projects. Since 2009, patient representatives have been actively involved in EULAR projects, and the first EULAR training course for patient representatives was conducted in 2010. <h3>Objectives</h3> The aim of the project was to create a training course for German-speaking patient representatives and thereby to invigorate the principle of participatory research in Germany. The training course is supposed to enable patients to make valuable contributions in research projects. In addition the training course aimed at lowering barriers and strengthening the patients9 self-confidence, in order to facilitate their integration in the unfamiliar environment among researchers. <h3>Methods</h3> Participants were trained during a two-day interactive training course. For evaluation of the course, each participant anonymously answered 14 questions in a questionnaire. <h3>Results</h3> The training course consists of seven modules. In the first module (I), the history of the EULAR "patient research partners" is described and the tasks of the future German patient research partners are outlined. In the following modules, various types of research and study designs (II), the generation of research questions and hypotheses (III), various scientific tools (IV), the detailed sequence of steps in a typical research project (V), literature research in scientific databases (VI) and the process of reviewing grant applications (VII) are explained. Each module is subdivided in an explanatory section, an exercise section (where the participants have to apply the newly achieved skills) and a final discussion section. So far, two courses have been conducted. The training course was rated either "very good" or "good" by 77% and 23% of the participants, respectively. Those patients, already actively involved in research projects, acclaim participatory research as interesting and enriching. <h3>Conclusions</h3> The training course was perceived very well by the participants. In future follow-up meetings, the usefulness of the various modules and any missing items will be discussed and the training course adapted accordingly. <h3>Acknowledgements</h3> We thank Dr. C. Sander for her contribution to the training course. <h3>Disclosure of Interest</h3> None declared