tbuckley/cabot-search huggingface dataset:
Viable cryopreserved umbilical tissue (vCUT) reduces post-operative adhesions in a rabbit abdominal adhesion model
Authors: Sandeep Dhall, Turhan Coksaygan, Tyler Hoffman, Matthew Moorman, Anne Lerch, Jin-Qiang Kuang, Malathi Sathyamoorthy, Alla Danilkovitch
Journal: Bioactive Materials (2018)

Post-operative adhesions, a common complication of surgery, cause pain, impair organ functionality, and often require additional surgical interventions. Control of inflammation, protection of injured tissue, and rapid tissue repair are critical for adhesion prevention. Adhesion barriers are biomaterials used to prevent adhesions by physical separation of opposing injured tissues. Current adhesion barriers have poor anti-inflammatory and tissue regenerative properties. Umbilical cord tissue (UT), a part of the placenta, is inherently soft, conforming, biocompatible, and biodegradable, with antimicrobial, anti-inflammatory, and antifibrotic properties, making it an attractive alternative to currently available adhesion barriers. While use of fresh tissue is preferable, availability and short storage time limit its clinical use. A viable cryopreserved UT (vCUT) “point of care” allograft has recently become available. vCUT retains the extracellular matrix, growth factors, and native viable cells with the added advantage of a long shelf life at −80 °C. In this study, vCUT's anti-adhesion property was evaluated in a rabbit abdominal adhesion model. The cecum was abraded on two opposing sides, and vCUT was sutured to the abdominal wall on the treatment side; whereas the contralateral side of the abdomen served as an internal untreated control. Gross and histological evaluation was performed at 7, 28, and 67 days post-surgery. No adhesions were detectable on the vCUT treated side at all time points. Histological scores for adhesion, inflammation, and fibrosis were lower on the vCUT treated side as compared to the control side. In conclusion, the data supports the use of vCUT as an adhesion barrier in surgical procedures.
Frontline bortezomib, rituximab, cyclophosphamide, doxorubicin, and prednisone (VR-CAP) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in transplantation-ineligible patients with newly diagnosed mantle cell lymphoma: final overall survival results of a randomised, open-label, phase 3 study
Authors: Tadeusz Robak, Jie Jin, Halyna Pylypenko, Gregor Verhoef, Noppadol Siritanaratkul, Johannes Drach, Markus Raderer, Jiri Mayer, Juliana Pereira, Gayane Tumyan, Rumiko Okamoto, Susumu Nakahara, Peter Hu, Carlos Appiani, Sepideh Nemat, Franco Cavalli, Achiel Van Hoof, Adriana Sheliga, Adriana Teixeira, Akihiro Tomita, Albert Oriol Rocafiguera, Alexander Suvorov, Alexy Kuzmin, Ali Khojasteh, Amel Mezlini, Anatoly Golenkov, Andre Bosly, Andrew Belch, Ann Van De Velde, Árpád Illes, Ashis Mukhopadhyay, Balkis Meddeb, Bernard De Prijck, Bernardo Garichochea, Bulent Undar, Caballero Gabarrón, Carmen Cao, Carmino Souza, Charles Farber, Cheol Won Suh, Cristina Ileana Burcoveanu, Cristina Ligia Cebotaru, Cristina-Ligia Truica, Dai Maruyama, David Belada, Dina Ben Yehuda, Dmitry Udovitsa, None Dolores, Enrica Morra, Ernst Späth-Schwalbe, Eva Gonzalez-Barca, Evgenii Osmanov, Francisco Javier Capote, Fritz Offner, Galvez Cardenas, Georg Heß, Georgii Manikhas, Govind Babu, Grigoriy Rekhtman, Guiseppe Rossi, Herlander Marques, Horia Bumbea, Huaqing Wang, Huiqiang Huang, Ilseung Choi, Irina Bulavina, Irina Lysenko, Irit Avivi, Iryna Kryachok, Jan Maciej Zaucha, Jan Novak, Joaquín Díaz, Judit Demeter, Julia Alexeeva, Jun Zhu, Kateryna Vilchevskaya, Kenichi Ishizawa, Kenny Mauricio, Kensei Tobinai, Kiyoshi Ando, Kudrat Abdulkadryrov, Lee-Yung Shih, Lyudmila Kuzina, Mahmut Gumus, Maike De Wit, Marcelo Capra, Margarida Marques, Marina Golubeva, Mario Ojeda-Uribe, Maryna Kyselyova, Masafumi Taniwaki, Massimo Federico, Michael Crump, Michele Baccarani, Michinori Ogura, Miklós Egyed, Miklos Udvardy, Mitsutoshi Kurosawa, Naokuni Uike, Nuriet Khuageva, Ofer Shpilberg, Oleg Gladkov, Olga Samoilova, Olga Serduk, Patricia Santi, Pierre Zachee, Polina Kaplan, Razvan Stoia, Remy Gressin, Reyes Arranz, Richard Greil, Sebastian Grosicki, Sergio Cancelado, Sreejith Nair, Steven Le Gouill, Steven Van Steenweghen, Sung-Soo Yoon, Suporn Chuncharune, Tatiana Scheider, Tatsu Shimoyama, Ting Liu, Tomohiro Kinoshita, Toshiki Uchida, Udomsak Bunworasate, Umberto Vitolo, Viacheslav Pavlov, Vijay Rao Phooshkooru, Vladimir Lima, Vladimir Merkulov, Weerasak Nawarawong, Xiaonan Hong, Xiaoyan Ke, Yasuhito Terui, Yeow Tee Goh, Yoshiharu Maeda, Yuankai Shi, Yuri Dunaev, Yurii Lorie, Zhao Wang, Zhixiang Shen, Zita Borbenyi, Zoltán Gasztonyi, Zvenyslava Masliak
Journal: The Lancet Oncology (2018)
Abstract 14401: Coronary Calcium Quantification in Patients With Normal Cardiac PET/CT Imaging Identifies Patients With Residual High Risk of MACE at One Year
Authors: Viet T Le, Raymond O McCubrey, Kurt R Jensen, Hannah Raasch, Steve Mason, Stacey Knight, Kent G Meredith, Donald L Lappé, Denise Bruno, Jeffrey L Anderson, Kirk U Knowlton, Joseph B Muhlestein
Journal: Circulation (2016)

Introduction: Cardiac PET/CT is a coronary imaging modality with increased accuracy over SPECT and can be used to quantify coronary artery calcification (CAC). Whether obtaining a separate CAC scor...
THU0539 Mechanical traction for lumbar radicular pain: supine or prone? a randomised controlled trial
Authors: M. Bilgilisoy Filiz, Z. Kılıç, A. Uçkun, T. Çakır, S. Koldaş Do&gbreve;an, N.F. Toraman
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Mechanical lumbar traction has been used to treat spinal disorders and low back pain for centuries, since Hippocrates(.<sup>2,3</sup>Although the supine position is generally preferred, the patient may also be positioned prone during traction treatment(.<sup>4,5</sup> However, to the best of our knowledge, no studies have compared the effects of lumbar traction in these two different positions for patients with chronic LBP. <h3>Objectives</h3> To compare the effects of mechanical lumbar traction either in the supine or prone position with conventional physical therapy(PT) in patients with chronic low back pain(LBP) and lumbosacral nerve root involvement in terms of disability, pain, and mobility. <h3>Methods</h3> Participants(n=125) were randomly assingned to receive 15 sessions of PT with additional mechanical lumbar traction either in the supine position (supine traction group), or in the prone position (prone traction group), or only PT without traction(PT only group). Patients were assessed at baseline and at the end of the PT sessions in terms of disability, pain, and mobility. Disability was assessed using the modified Oswesty Disability Index (ODI); pain was assessed using a visual analogue scale (VAS); and lumbar mobility was assessed using the modified lumbar Schober test (mLST). <h3>Results</h3> 118 patients completed the trial. All groups improved significantly in the ODI, VAS, and mLST (p&lt;0.05) (table 1). In the between-group analysis, improvements of ODI and VAS were found significantly better in the prone traction group compared with the PT only group (adjusted p=0.031 and.006, respectively). <h3>Conclusions</h3> Addition of traction in prone position to other modalities resulted in larger immediate improvements in terms of pain and disability, and the results suggest that when using traction, prone traction might be first-choice. Further research is needed to confirm the benefits of lumbar traction in the prone position. <h3>References</h3> [1] Marketos SG, Skiadas P. Hippocrates. The father of spine surgery. Spine1999;24:1381–7. [2] Krause M, Refshauge KM, Dessen M, et al. Lumbar spine traction: evaluation of effects and recommended application for treatment. Manual therapy2000;5:72–81. [3] Harte AA, Gracey JH, Baxter GD. Current use of lumbar traction in the management of low back pain: results of a survey of physiotherapists in the UK. Archives of physical medicine and rehabilitation2005;86:1164–9. [4] Fritz JM, Lindsay W, Matheson JW, et al. Is there a subgroup of patients with low back pain likely to benefit from mechanical traction? Results of a randomized clinical trial and subgrouping analysis. Spine2007;32:E793–800. <h3>Disclosure of Interest</h3> None declared
What is the added value of the waist‐to‐hip ratio on top of the BIOSTAT risk prediction model in patients with heart failure? Reply
Authors: Koen W. Streng, Chim C. Lang, Adriaan A. Voors
Journal: European Journal of Heart Failure (2018)

We thank Dr. Cao for his interest in our paper. Dr. Cao addresses an important topic regarding the study design of the BIOSTAT-CHF study. Almost all patients included were Caucasian patients, and to conclude that the same association of waist-to-hip ratio (WHR) with mortality exists in other ethnicities, further studies should be performed.1 The second question raised by Dr. Cao is the additive value of WHR on top of the risk prediction model within BIOSTAT-CHF.2 The prediction models were developed to assess the strongest predictors for mortality and/or heart failure hospitalization. The predictors in BIOSTAT-CHF for mortality were age, blood urea nitrogen, N-terminal pro-B-type natriuretic peptide, haemoglobin and use of beta-blocker. In our multivariable model, we aimed to assess the independent association of WHR with all-cause mortality within male and female patients with heart failure, and therefore corrected for all confounders. The BIOSTAT-CHF prediction model contains the strongest predictors for mortality, and were also confounders in our manuscript. Therefore we included these variables in our multivariable Cox regression models, together with other confounders. We found that WHR was independently associated with all-cause mortality in female patients with heart failure.3 The additive value of WHR on the risk prediction model is therefore not the aim of our manuscript, we merely aimed to investigate the independent association of WHR with all-cause mortality, and therefore corrected for the previously published risk prediction model. The last question raised by Dr. Cao regards the association of adiposity and pro-inflammatory cytokines such as C-reactive protein. Unfortunately there are no available C-reactive protein measurements in our cohort. However, we found a strong association with a panel of inflammatory markers, especially in female heart failure patients.
Abstract 16963: A Novel Rehabilitation Intervention for Older Patients with Acute Decompensated Heart Failure: the REHAB-HF Pilot Study
Authors: Gordon R Reeves, Mahesh J Patel, David J Whellan, Christopher O’Connor, Joel D Eggebeen, Pamela Duncan, Timothy M Morgan, Leigh A Hewston, Amy Pastva, Patricia A Adams, Suzanne Adams, Dalane W Kitzman
Journal: Circulation (2014)

Introduction: Exercise training improves outcomes in patients with chronic, stable heart failure (HF). However, little is known regarding patients with acute decompensated HF (ADHF) who are typically elderly, frail, with multiple co-morbidities and frequent rehospitalizations. Hypothesis: A novel rehabilitation intervention in older patients hospitalized for ADHF will be feasible and safe, improve physical function and reduce rehospitalizations. Methods: This was a 3-site, randomized, attention-controlled pilot study of a tailored, progressive, multi-domain (strength, balance, mobility and endurance) rehabilitation intervention beginning in the hospital and continuing for 12 weeks post-discharge. The primary outcome was the Short Physical Performance Battery (SPPB) score, a standardized measure of physical function in frail elderly, assessed by a blinded observer; the secondary outcome was rehospitalizations. Results: We enrolled 27 patients aged 60-98 years: 59% women, 56% African-American, 41% preserved EF. Patients had ~ 5 co-morbidities and markedly impaired physical function; &gt; 50% were frail. Characteristics were similar between groups. Study retention (89%) and intervention adherence (93%) were excellent. Figure 1 shows change in SPPB score and 6-minute walk distance. All-cause rehospitalizations were reduced by 29% (1.16±0.35 vs. 1.64±0.39) and all-cause rehospitalization days were reduced by 47% (6.0± 2.5 vs. 11.4±2.8) at 6 month follow-up. The change in SPPB score explained 90% of the reduction in all-cause rehospitalizations. There were no adverse events related to the intervention. Conclusions: These findings support the feasibility, safety and potential efficacy of a novel multi-domain rehabilitation intervention to improve physical function and reduce rehospitalizations in older, frail ADHF patients with multiple comorbidities. An NIH-funded multi-center trial is being launched to confirm these findings.
GW29-e0848 Assessment of the Blood Flow in the Subepicardial and Subendocardial Myocardium Before and After Percutaneous Coronary Interventions
Authors: Thach Nguyen, Thao Dang, Tu NT. Nguyen, Le Dieu Anh, Le Nhan Tam, Tarneem Darwish, Gianluca Rigatelli
Journal: Journal of the American College of Cardiology (2018)
P3.09-15 Genetic Profiling of Idiopathic Pulmonary Fibrosis Associated Non-Small Cell Lung Cancer by Targeted Next-Generation Sequencing
Authors: K. Otsubo, E. Iwama, K. Tanaka, Y. Shiraishi, Y. Yoneshima, H. Inoue, T. Tagawa, Y. Nakanishi, I. Okamoto
Journal: Journal of Thoracic Oncology (2018)
GW29-e0367 PTEN Induced Putative Kinase 1 (PINK1) Regulates Mitophagy to Alleviate Angiotensin II-Induced Cardiac Injury
Authors: Wenjun Xiong, Jiaying Li, Zhengliang Peng, Zhuang Ma, Xiangkun Xie, Hanlin Li, Zhen Se, Wenyan Lai, Qiong Zhan, Qingchun Zeng, Hao Ren, Dingli Xu
Journal: Journal of the American College of Cardiology (2018)
Mechanisms of Myocardial Infarction in Patients With Nonobstructive Coronary Artery Disease
Authors: Maksymilian P. Opolski, Mateusz Spiewak, Magdalena Marczak, Artur Debski, Paul Knaapen, Stefan P. Schumacher, Adam D. Staruch, Kajetan Grodecki, Zbigniew Chmielak, Hubert Lazarczyk, Krzysztof Kukula, Pawel Tyczynski, Jerzy Pregowski, Maciej Dabrowski, Jacek Kadziela, Elzbieta Florczak, Anna Skrobisz, Adam Witkowski
Journal: JACC. Cardiovascular imaging (2018)
Analyses of CD204+ macrophages in allogeneic stem cell transplantation for malignant lymphoma in non-remission
Authors: Akihisa Kawajiri, Shigehisa Kitano, Akiko Maeshima, Yoshihiro Inamoto, Kinuko Tajima, Tomonari Takemura, Takashi Tanaka, Ayumu Ito, Keiji Okinaka, Saiko Kurosawa, Sung-Won Kim, Chitose Ogawa, Koji Izutsu, Noboru Yamamoto, Takahiro Fukuda
Journal: Annals of Oncology (2018)
Abstract 12227: New Insights Into Calcification and Aortic Stenosis Using 4-dimensional Computed Tomography.
Authors: William S Jenkins, Louis Simard, Jérome Hourdain, Marie-Annick Clavel, Maurice Enriquez-Sarano
Journal: Circulation (2016)

Background: Aortic Valve Calcification (AVC) is intrinsic to aortic stenosis (AS). While established concepts assume homogeneous calcification causing AS, wide variability in hemodynamic severity at any given AVC burden suggests other operative mechanisms. Multidetector computed tomography (MDCT) now accurately measures global AVC, but AVC spatial distribution remains elusive due to imaging orientation. Methods and Results: We developed ‘en-face’ imaging by re-registration of 4D-MDCT to quantify AVC spatial distribution and analyzed global AVC load and AVC distribution in 418 patients with AS (76±9 years; mean gradient 35±17 mmHg). 4D-volume-rendered MDCT datasets were re-oriented to en-face view of aortic valve for AVC spatial scoring with individual cusp calcification load, cusp-edge calcification and AVC asymmetry. Despite high total AVC load (450 [250-666] AU/cm 2 ), asymmetry was frequent (50%), with a difference between most- and least-calcified cusp of 112 [66-182] AU/cm 2 . Maximum AVC was in the non-coronary cusp in 61% (p&lt;0.001). Cusp edge calcification was none-mild in 26%, moderate in 62% and severe in 12%. Adjusting for total AVC, severe AS (mean gradient &gt;40 mmHg) was more likely with symmetrical AVC (odds ratio [OR] 2.36, p&lt;0.001) and with edge calcification moderate (OR 4.16, p=0.001 vs none-mild) to severe (OR 10.7, p=0.001). Inclusion of AVC distribution improved models predicting AS severity over total AVC (p&lt;0.001). Conclusions: Four-dimensional MDCT en-face re-registration and AVC quantitation provides new insight into AS pathophysiology. Contrary to classical concepts, AVC is frequently inhomogeneous and asymmetric. Hemodynamic AS severity is independently affected not only by global AVC but also by variations in AVC distribution and location within cusps, emphasizing the importance of 4D AVC assessment in AS. Impact of quantified AVC asymmetry and location on outcome of transcutaneous aortic valve replacement should be evaluated.
JNJ-61186372 (JNJ-372), an EGFR-cMET bispecific antibody, in advanced non-small cell lung cancer (NSCLC): An update on phase I results
Authors: B.C. Cho, J.-S. Lee, J.-Y. Han, E.K. Cho, E. Haura, K.H. Lee, J. Bauml, R.E. Sanborn, M. Curtis, E. Attiyeh, N. Haddish-Berhane, K. Bae, R. Knoblauch, L. Sherman, M.V. Lorenzi, K. Park
Journal: Annals of Oncology (2018)
Mediastinal Lymphadenopathy in Interstitial Lung Disease. Time to Be Counted
Authors: Simon L. F. Walsh
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

benefit.The results of one study conducted in rural Guatemala suggest that reduced exposure to HAP through the use of a chimney stove intervention could improve lung function as measured by spirometry later in childhood (11).Poverty is inextricably intertwined with exposure to HAP as drivers of early-childhood respiratory illnesses that put children on a lower lung function growth trajectory and at increased risk of developing an adult respiratory illness (12).As the economies of LMICs develop, increased emissions from traffic and power generation will contribute to the cumulative exposure to air pollution.A great challenge for public health officials in these countries will be to prevent increased exposures of children to air pollution while the necessary economic development is being pursued.Distributed energy generation from solar-power microgrids is one potential solution, but the search for low-cost, feasible, clean cooking solutions must continue so that this public health problem can be addressed sooner rather than later.
Effect of in utero hydroxychloroquine exposure on the development of cutaneous neonatal lupus erythematosus
Authors: Julie Barsalou, Nathalie Costedoat-Chalumeau, Adey Berhanu, Cesar Fors-Nieves, Ummara Shah, Patrick Brown, Carl A Laskin, Nathalie Morel, Kateri Levesque, Jill P Buyon, Earl D Silverman, Peter M Izmirly
Journal: Annals of the Rheumatic Diseases (2018)

Objective Cutaneous neonatal lupus (cNL) occurs in possibly 5%–16% of anti-Ro±anti-La antibody–exposed infants. Data suggest in utero exposure to hydroxychloroquine (HCQ) may prevent cardiac NL. The aim was to assess whether in utero exposure to HCQ decreases the risk of cNL and/or delays onset. Methods A multicentre case–control study was performed with 122 cNL cases and 434 controls born to women with a rheumatological disease who had documentation of maternal anti-Ro±anti-La antibodies at pregnancy and confirmation of medication use and the child’s outcome. A secondary analysis was performed on 262 cNL cases, irrespective of maternal diagnosis, to determine if HCQ delayed time to cNL onset. Results Twenty (16%) cNL cases were exposed to HCQ compared with 146 (34%) controls (OR 0.4 (95% CI 0.2 to 0.6); p&lt;0.01). Exposure to HCQ was associated with a reduced risk of cNL; exposure to anti-La antibody and female gender were associated with an increased risk of cNL. Exposure to HCQ remained significantly associated with a reduced cNL risk in the analyses limited to mothers with systemic lupus erythematosus and those who developed rash ≤1 month. When analysing all 262 cNL cases, HCQ-exposed infants were older (6.0 (95% CI 5.7 to 6.3) weeks) at cNL onset versus HCQ-non-exposed infants (4.4 (95% CI 3.9 to 5.0) weeks), but the difference was not statistically significant (p=0.21). Conclusion Exposure to HCQ was associated with a reduced risk of cNL. Among cNL cases, those exposed to HCQ tend to have later onset of rash. Both findings suggest a protective effect of HCQ on cNL.
A randomized phase II study of cabazitaxel (CAB) vs (ABI) abiraterone or (ENZ) enzalutamide in poor prognosis metastatic castration-resistant prostate cancer (mCRPC)
Authors: K.N. Chi, S. Taavitsainen, N. Iqbal, C. Ferrario, M. Ong, D. Wadhwa, S.J. Hotte, G. Lo, B. Tran, A. Azad, L. Wood, J.R. Gingerich, S. North, C.V. Pezaro, D. Ruether, S.S. Sridhar, M. Annala, J. Bacon, A.W. Wyatt
Journal: Annals of Oncology (2018)
Abstract 17770: Reduced-Dose Non-Vitamin K Antagonist Oral Anticoagulants Are More Frequently Prescribed to Women but May Not Be Responsible for Poorer Outcomes
Authors: Xiaoxi Yao, Bernard J Gersh, Nilay D Shah, Lindsey R Sangaralingham, Peter A Noseworthy
Journal: Circulation (2016)

Introduction: Over the past few years, four non-vitamin K antagonist oral anticoagulants (NOACs) have been widely adopted for stroke prevention in atrial fibrillation (AF). Early non-trial data suggested that women treated with dabigatran were more frequently prescribed with the reduced dose instead of the standard dose. This observation raised concerns that women may receive suboptimal NOAC treatment. Hypothesis: Women are more likely than men to receive reduced-dose NOACs, but this prescribing pattern may reflect higher risk profile in women that justifies the use of a reduced dose. Methods: Using a large U.S. commercial insurance database, we identified 39,539 patients with AF, among whom apixaban, dabigatran, edoxaban or rivaroxaban was initiated between 10/1/2010 and 6/30/2015. We performed one-to-one propensity score matching between patients receiving reduced doses and patients receiving standard doses, in women and men separately. Cox proportional hazards regression was used to assess the relation...
GW29-e0859 Investigation of Central Venous Oxygen Saturation Substitutes Mixed Venous Oxygen Saturation in Postoperative Care of Congenital Heart Disease with Pulmonary Arterial Hypertension
Authors: Dianyuan Li, Shuai Hu, Jianwen Liang, Jingjun Han, Wenbin Wei, Deqiang Wu, Lei Zhang, Yangui Lin, Zhiyan Han
Journal: Journal of the American College of Cardiology (2018)