Breast Cancer Screening in Denmark
Authors: Karsten Juhl Jørgensen, Peter C. Gøtzsche, Mette Kalager, Per-Henrik Zahl
Journal: Annals of Internal Medicine (2017)

Letters3 October 2017Breast Cancer Screening in DenmarkKarsten Juhl Jørgensen, MD, DrMedSci, Peter C. Gøtzsche, MD, MSc, Mette Kalager, MD, PhD, and Per-Henrik Zahl, MD, DrMedSciKarsten Juhl Jørgensen, MD, DrMedSciFrom Nordic Cochrane Centre, Copenhagen, Denmark, and University of Oslo and Norwegian Institute of Public Health, Oslo, Norway., Peter C. Gøtzsche, MD, MScFrom Nordic Cochrane Centre, Copenhagen, Denmark, and University of Oslo and Norwegian Institute of Public Health, Oslo, Norway., Mette Kalager, MD, PhDFrom Nordic Cochrane Centre, Copenhagen, Denmark, and University of Oslo and Norwegian Institute of Public Health, Oslo, Norway., and Per-Henrik Zahl, MD, DrMedSciFrom Nordic Cochrane Centre, Copenhagen, Denmark, and University of Oslo and Norwegian Institute of Public Health, Oslo, Norway.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0270 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Overdiagnosis of ductal carcinoma in situ has become generally acknowledged, but some still find overdiagnosis of invasive breast cancer difficult to accept. However, our estimate of the latter is lower than estimates of overdiagnosis of prostate cancer from screening with prostate-specific antigen testing, lung cancer from screening with chest radiography, neuroblastoma, and thyroid cancer. The fundamental question is whether the observed increase in incidence with screening is caused by a desired advancement of the time of diagnosis or by overdiagnosis. If the observed substantial increase is not followed by a decline in incidence in previously screened age groups, ...References1. Jørgensen KJ, Zahl PH, Gøtzsche PC. Breast cancer mortality in organised mammography screening in Denmark: comparative study. BMJ. 2010;340:c1241. [PMID: 20332505] doi:10.1136/bmj.c1241 CrossrefMedlineGoogle Scholar2. Gøtzsche PC, Jørgensen KJ. Screening for breast cancer with mammography. Cochrane Database Syst Rev. 2013:CD001877. [PMID: 23737396] doi:10.1002/14651858.CD001877.pub5 CrossrefMedlineGoogle Scholar3. Autier P, Boniol M, La Vecchia C, LaVecchia C, Vatten L, Gavin A, et al. Disparities in breast cancer mortality trends between 30 European countries: retrospective trend analysis of WHO mortality database. BMJ. 2010;341:c3620. [PMID: 20702548] doi:10.1136/bmj.c3620 CrossrefMedlineGoogle Scholar4. Carter JL, Coletti RJ, Harris RP. Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods. BMJ. 2015;350:g7773. [PMID: 25569206] doi:10.1136/bmj.g7773 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Nordic Cochrane Centre, Copenhagen, Denmark, and University of Oslo and Norwegian Institute of Public Health, Oslo, Norway.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-0270. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBreast Cancer Screening in Denmark Karsten Juhl Jørgensen , Peter C. Gøtzsche , Mette Kalager , and Per-Henrik Zahl Breast Cancer Screening in Denmark Sameer Bhargava , Kaitlyn Tsuruda , and Solveig Hofvind Breast Cancer Screening in Denmark Tony H.H. Chen and Stephen W. Duffy Breast Cancer Screening in Denmark Changjun Wang , Yidong Zhou , Feng Mao , Yan Lin , and Qiang Sun Metrics Cited byScreening and Selection: The Case of MammogramsCauses for Frequent Pathogenic BRCA1 Variants Include Low Penetrance in Fertile Ages, Recurrent De-Novo Mutations and Genetic DriftScreening for Chronic Disease 3 October 2017Volume 167, Issue 7Page: 524KeywordsAge groupsBreast cancerCancer screeningDuctal carcinoma in situLung and intrathoracic tumorsMortalityRandomized trialsThoraxThyroidThyroid carcinoma ePublished: 3 October 2017 Issue Published: 3 October 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...