tbuckley/cabot-search huggingface dataset:
Abstract 30: Women with a Bad Prognosis After Return of Spontaneous Circulation After Out-of Hospital Cardiac Arrest: A Retrospective Study in 1 Emergency Center
Authors: Jin Joo Kim, Se Jong Oh, Hong Seop Lee, Jo Eun Han, Sung Youl Hyun
Journal: Circulation (2011)

Introduction: Several studies were reported that women in child-bearing period have a good prognosis than men in hypoxic brain damage, traumatic brain injury and so on. That is, hormones like progesterone and estrogen have a neuroprotective effect and these are abundant in young women. The aim of this study was to analyze the gender factors associated with good or bad prognosis after return of spontaneous circulation after out-of hospital cardiac arrest Methods: The patients admitted to the intensive care unit after successful resuscitation after out-of hospital cardiac arrest were retrospectively identified and evaluated. Basal characteristic of the patients including factors associated with social history, basic life support and advanced cardiovascular life support were analyzed. Ninety days mortality after admission and neurologic outcome (cerebral performance category[CPC]) were evaluated. Result: One hundred forty-two patients were evaluated in this study; there were 101 males (71.1%). The median age was 52 years old (43-63). Ninety days after admission, 85 patients (59.9%) survived. 40 patients had a good neurologic outcome (CPC 1-2). The factors associated 90 days mortality were cause of death (non-cardiac, p=0.03), lactate in emergency department (p=0.05) and the factors associated with good neurologic outcome were males (p=0.007), young age (p=0.01), body weight and height (p=0.001), cause of death (cardiac, p=0.000), witnessed arrest(p=0.012). Alcohols and smoking were not associated with mortality and neurologic outcome. In multivariable logistic regression analysis, the patients in women had a 8-fold increased risk(odds ratio [OR] 8.038, 95% Confidence Interval [CI] 1.079-59.903) to poor neurologic outcome(CPC 3-5). Other factors associated with poor neurologic outcome were non-cardiac cause of death (OR 5.523, 95% CI 1.562-19.533) and old age (over 65 years old, OR 1.055, 95% CI 1.009-1.103). Conclusion: Women had a poor neurologic outcome after return of spontaneous circulation after out-of hospital cardiac arrest in one emergency center. Known gender-related neuroprotective hormonal factors might not be associated this gender differences. Other additional factors should be evaluated.
Puncion aspiracion con aguja fina guiada por ultrasonografia endoscopia: Estudio retrospectivo de 495 casos
Authors: A Castellot Martín, MS Martínez Martín, L Betancor Hernández, JM De Lera Martínez, L Peña Ferrera, A Cruz Bonilla, I Ciordia Naldas, L García Villarreal, J Rodríguez Castellot, JM Marrero Monroy
Journal: Endoscopy (2017)

La punción aspiración con aguja fina guiada por ecoendoscopia (USE-PAAF) permite el diagnóstico citológico de lesiones del tubo digestivo y de órganos adyacentes.
Incidencia de bacteriemias por S. aureus en los hospitales del área Centro-Oeste en Irlanda, 2002-2004
Authors: D Whyte, R Monahan, L Boyle, B Slevin, R FitzGerald, D Barron, J De Freitas, K Kelleher
Journal: Eurosurveillance (2005)

La mayor preocupacion frente a las infecciones nosocomiales y el fenomeno mundial de resistencia antimicrobiana aumentaron la inquietud de lo que los anglofonos denominan “superbug”. En Irlanda, no hay un indicador considerado fiable para medir el nivel de Staphylococcus aureus resistentes a la meticilina (SARM) en los hospitales. El objetivo del presente estudio fue comparar dos medidas brutas de SARM – el porcentaje de bacteriemias debidas a los SARM y la tasa de incidencia (por 1.000 camas ocupadas/dia) de los SARM en seis hospitales. Se analizaron todas las muestras de sangre positivas para S. aureus (sensibles o resistentes a la meticilina) entre 2002 y 2004, en la region Centro-Oeste de Irlanda. Los datos de los registros medicos (Hospital In-Patient Enquiry, HIPE) sirvieron para calcular cada mes la tasa de ocupacion de las camas. De los 245 episodios de bacteriemias de pacientes, 119 eran SARM. Las tendencias de los porcentajes de aislamientos de SARM fueron comparados con las tasas de incidencia calculadas. La tasa de incidencia parece ser un indicador de SARM en los hospitales mas fiable y solido que el porcentaje. Las dificultades de interpretacion de los indicadores de SARM no deberian impedir la publicacion regular de datos, por lo menos al nivel regional, en Irlanda.
CONFOCAL LASER ENDOMICROSCOPY IN DIAGNOSING GASTRIC AND ESOPHAGEAL LESIONS AND IN POST-RFA SURVEILLANCE OF PATIENTS WITH BARRETT'S ESOPHAGUS
Authors: J Krajciova, M Kollar, J Maluskova, Z Vackova, J Spicak, J Martinek
Journal: Endoscopy (2018)

Confocal laser endomicroscopy (CLE) has been developed to overcome limitations of the current endoscopic sampling techniques. The aim of this study was to evaluate the accuracy of CLE for the differential diagnosis of non-neoplastic and neoplastic lesions in the esophagus and the stomach (Part A) and whether the use of CLE could help in determination of recurrent metaplasia/neoplasia in patients after endoscopic treatment of Barrett's esophagus related neoplasia (BORN) (Part B).
The Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference
Authors: Renée S. Koolschijn, Uzay E. Emir, Alexandros C. Pantelides, Hamed Nili, Timothy E.J. Behrens, Helen C. Barron
Journal: Neuron (2018)

Our experiences often overlap with each other, yet we are able to selectively recall individual memories to guide decisions and future actions. The neural mechanisms that support such precise memory recall remain unclear. Here, using ultra-high field 7T MRI we reveal two distinct mechanisms that protect memories from interference. The first mechanism involves the hippocampus, where the blood-oxygen-level-dependent (BOLD) signal predicts behavioral measures of memory interference, and representations of context-dependent memories are pattern separated according to their relational overlap. The second mechanism involves neocortical inhibition. When we reduce the concentration of neocortical GABA using trans-cranial direct current stimulation (tDCS), neocortical memory interference increases in proportion to the reduction in GABA, which in turn predicts behavioral performance. These findings suggest that memory interference is mediated by both the hippocampus and neocortex, where the hippocampus separates overlapping but context-dependent memories using relational information, and neocortical inhibition prevents unwanted co-activation between overlapping memories.
ENDOSCOPIC CLOSURE OF GIANT ESOPHAGEAL PERFORATION IN BOERHAAVE'S SYNDROME USING SPONGE AND VACUUM THERAPY
Authors: G Loske, A Martinez-Alcala, LC Fry, K Mönkemüller
Journal: Endoscopy (2018)

Esophageal perforation in the setting of Boerhaave's syndrome is highly letal. The main treatment option is thoracotomy with surgical drainage. Occasionally the use of fully covered metal stents may assist closing smaller perforation, Herein we present the effectiveness of endoscopic sponge and vacuum therapy to fully close a huge esophageal perforation with mediastinal cavity in a severely ill patient.
Five Questions That Every Patient Has but Never Asks
Authors: John Whyte
Journal: JAMA Neurology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
The Hairy Family of Burma: A Four Generation Pedigree of Congenital Hypertrichosis Lanuginosa
Authors: J Bondeson, A E W Miles
Journal: Journal of the Royal Society of Medicine (1996)

A Burmese family with congenital hypertrichosis lanuginosa had an eventful history in the nineteenth century. The earlier members of this family were employed at the court of Ava, but the later ones spent their lives in show business, being widely exhibited for money in the 1880s. Their extraordinary hairiness attracted much curiosity, and they were photographed several times. The hairy Burmese are the only example of a four-generation pedigree of congenital hypertrichosis lanuginosa, which is consistent with an autosomal dominant mode of inheritance. There is good evidence that, when the members of this family were hairy, their dentition was also deficient.
Digital GP providers that register out-of-area patients could receive less funding under contract revamp
Authors: Gareth Iacobucci
Journal: BMJ (2018)

“Digital first” GP providers that register patients from outside their geographical area could receive less money per patient than practices that offer a more complete service, under proposals put forward by NHS England.

The plans are outlined in a consultation document examining how general practice payments might change to “fairly support” the rollout of digital technology around the country.1

It follows concerns that the current GP funding model is not designed to account for new “digital first” providers such as GP in Hand and that this is endangering the financial sustainability of other GP services.

GP at Hand, launched by Babylon Health at a practice in the Hammersmith …
Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer
Authors: Nora Pashayan, Steve Morris, Fiona J. Gilbert, Paul D. P. Pharoah
Journal: JAMA Oncology (2018)

The age-based or "one-size-fits-all" breast screening approach does not take into account the individual variation in risk. Mammography screening reduces death from breast cancer at the cost of overdiagnosis. Identifying risk-stratified screening strategies with a more favorable ratio of overdiagnoses to breast cancer deaths prevented would improve the quality of life of women and save resources.
Internet-based behavioural activation with lay counsellor support versus online minimal psychoeducation without support for treatment of depression: a randomised controlled trial in Indonesia
Authors: Retha Arjadi, Maaike H Nauta, Willem F Scholte, Steven D Hollon, Neerja Chowdhary, Angela O Suryani, Cuno S P M Uiterwaal, Claudi L H Bockting
Journal: The Lancet Psychiatry (2018)
Abstract 254: Should All Patients without Sustained Return of Spontaneous Circulation Following Ventricular Fibrillation Out-of Hospital Cardiac Arrest be Transported to Hospital?
Authors: Dion Stub, Ziad Nehme, Stephen Bernard, Marijana Lijovic, David M Kaye, Karen Smith
Journal: Circulation (2013)

Background: Many worldwide emergency medical services, including Ambulance Victoria, do not routinely transport patients without sustained return of spontaneous circulation (ROSC) following out-of-hospital cardiac arrests (OHCA), given the logistical difficulties and historical poor outcomes. The significant recent advancements in resuscitation techniques for prolonged cardiac arrest including mechanical chest compression and extracorporeal membrane oxygenation assisted CPR makes the decision of when and where to cease resuscitative efforts increasingly difficult. We aimed to explore the characteristics and outcomes of patients with OHCA who do not achieve sustained ROSC using the Victorian Ambulance Cardiac Arrest Registry (VACAR). Methods and Results: The VACAR was searched for adult non-EMS witnessed OHCAs with an initial shockable rhythm between 2003 and 2012. There were 5654 OHCA meeting inclusion criteria. Analysis was performed on 3095 (54%) of patients who did not achieve sustained ROSC in the field. Of these patients only 589 (20%) had ongoing CPR to hospital with the remainder declared deceased. Patients transported with ongoing CPR were younger (median 63 vs 68 years, p&lt;0.01), had shorter response times and time to first defibrillation, but longer resuscitation times (median 42 vs 33 minutes, p &lt;0.01). Survival to hospital discharge occurred in 52 (9%) of patients with ongoing CPR during transportation to hospital. 97% of these patients were discharged with a favourable neurological outcome. Independent predictors of a patient being transported to hospital with ongoing CPR included younger patients, who arrested in public places, and received longer resuscitation times. Conclusion: Patients receiving ongoing CPR during transport to hospital have better outcomes than previously reported. Declaring patients deceased in the field in the setting of an initial shockable rhythm, in which ROSC cannot be achieved may no longer be warranted. The further development of systems of care that incorporate transport of patients requiring ongoing CPR is urgently needed.
Test forMycoplasma genitaliumor risk it becoming a superbug, doctors warn
Authors: Jacqui Wise
Journal: BMJ (2018)

Sexual health experts have warned that the sexually transmitted infection Mycoplasma genitalium could become a “superbug”—resistant to first and second line antibiotics—if new guidelines are not fully implemented.

Draft guidelines from the British Association for Sexual Health and HIV (BASHH) recommend diagnostic testing for M genitalium which, if left untreated in women, can cause pelvic inflammatory disease and infertility.1 The infection is often misdiagnosed as chlamydia and treated as such, which encourages antimicrobial resistance.

However, a survey of 125 public health commissioners carried out for the organisation found that only one in 10 were making provisions for M genitalium testing in their 2019 budget. …
Estudio poblacional. Programa de cribado de cáncer colorrectal. Resultados en 47666 participantes
Authors: G Hontoria Bautista, MA Jiménez Moreno, R Pereda García, J Sanz Sánchez, B Bernad Cabredo, E Badia Aranda, B Sicilia Aladrén, S García Morán, JL Martín Lorente, F Sáez-Royuela Gonzalo
Journal: Endoscopy (2017)

El cáncer colorrectal (CCR) es uno de los más frecuentes. El cribado ha demostrado detectar CCR en estadíos precoces permitiendo un tratamiento más efectivo.
¿Es útil la ultrasonografía endoscópica (USE) en el estudio de las lesiones ampuares (LA)? Resultados en una serie de 33 casos
Authors: M Rodriguez Carrasco, C Cuadrado Tiemblo, M Pérez Carreras, M Algara San Nicolás, JC Marín Gabriel, A Del Pozo García, A Pérez Barrios, A Pérez Campos, JB Díaz Tasende, G Castellano Tortajada
Journal: Endoscopy (2017)

La complejidad estructural de la región ampular hace que su evaluación sea un desafío, especialmente a la hora de diferenciar LA benignas/malignas. Dada su elevada resolución espacial, se propone la USE como técnica más adecuada para ello.
Laminin-521 promotes quiescence in isolated stellate cells from rat liver
Authors: Friederike Rohn, Claus Kordes, Mirco Castoldi, Silke Götze, Gereon Poschmann, Kai Stühler, Diran Herebian, Amelie S. Benk, Fania Geiger, Tingyu Zhang, Joachim P. Spatz, Dieter Häussinger
Journal: Biomaterials (2018)
Normal Breast-Derived Epithelial Cells with Luminal and Intrinsic Subtype-Enriched Gene Expression Document Interindividual Differences in Their Differentiation Cascade
Authors: Brijesh Kumar, Mayuri Prasad, Poornima Bhat-Nakshatri, Manjushree Anjanappa, Maitri Kalra, Natascia Marino, Anna Maria Storniolo, Xi Rao, Sheng Liu, Jun Wan, Yunlong Liu, Harikrishna Nakshatri
Journal: Cancer Research (2018)

Abstract Cell-type origin is one of the factors that determine molecular features of tumors, but resources to validate this concept are scarce because of technical difficulties in propagating major cell types of adult organs. Previous attempts to generate such resources to study breast cancer have yielded predominantly basal-type cell lines. We have created a panel of immortalized cell lines from core breast biopsies of ancestry-mapped healthy women that form ductal structures similar to normal breast in 3D cultures and expressed markers of major cell types, including the luminal-differentiated cell-enriched ERα–FOXA1–GATA3 transcription factor network. We have also created cell lines from PROCR (CD201)+/EpCAM− cells that are likely the “normal” counterpart of the claudin-low subtype of breast cancers. RNA-seq and PAM50-intrinsic subtype clustering identified these cell lines as the “normal” counterparts of luminal A, basal, and normal-like subtypes and validated via immunostaining with basal-enriched KRT14 and luminal-enriched KRT19. We further characterized these cell lines by flow cytometry for distribution patterns of stem/basal, luminal-progenitor, mature/differentiated, multipotent PROCR+ cells, and organogenesis-enriched epithelial/mesenchymal hybrid cells using CD44/CD24, CD49f/EpCAM, CD271/EpCAM, CD201/EpCAM, and ALDEFLUOR assays and E-cadherin/vimentin double staining. These cell lines showed interindividual heterogeneity in stemness/differentiation capabilities and baseline activity of signaling molecules such as NF-κB, AKT2, pERK, and BRD4. These resources can be used to test the emerging concept that genetic variations in regulatory regions contribute to widespread differences in gene expression in “normal” conditions among the general population and can delineate the impact of cell-type origin on tumor progression. Significance: In addition to providing a valuable resource for the breast cancer research community to investigate cell-type origin of different subtypes of breast cancer, this study highlights interindividual differences in normal breast, emphasizing the need to use "normal" cells from multiple sources as controls to decipher the effects of cancer-specific genomic aberrations. Cancer Res; 78(17); 5107–23. ©2018 AACR.
Non-invasive diagnosis of liver fibrosis in patients with alcohol-related liver disease by transient elastography: an individual patient data meta-analysis
Authors: Eric Nguyen-Khac, Maja Thiele, Cosmin Voican, Pierre Nahon, Christophe Moreno, Jerome Boursier, Sebastian Mueller, Victor de Ledinghen, Peter Stärkel, Sang Gyune Kim, Michael Fernandez, Bjorn Madsen, Sylvie Naveau, Aleksander Krag, Gabriel Perlemuter, Marianne Ziol, Denis Chatelain, Momar Diouf
Journal: The Lancet. Gastroenterology & hepatology (2018)
SET THE TABLE WITH THE NAPKIN RING AND HOLDER: NOVEL ENDOSCOPIC MULTI-STENT TECHNIQUE FOR COMPLICATIONS FROM WEIGHT LOSS SURGERY
Authors: A Martínez-Alcalá García, A Edwards, RD Stibolt, R Stahl, A Mir Ahmed
Journal: Endoscopy (2018)

A 61 year-old female had a laparoscopic sleeve gastrectomy complicated by post-procedure vomiting and barium swallow demonstrated no passage of contrast at the GE junction. Endoscopy was notable for a high-grade angulation with redundant tissue at the proximal stomach but was able to pass into the proximal duodenum. Contrast outlined the sharp angulation and the narrowed proximal stomach measured 2 cm in length. Three overlapping 15 mm x 10 mm double lumen apposing metal stents (LAMS), (AXIOS, Boston Scientific Corp, Marlborough, MA, USA) were interlocked to traverse the stricture. Then a fully covered 18 mm x 100 mm through the scope esophageal stent (Niti-S, TaeWoong Medical, Gimpo, South Korea) was placed within the interlocking stents. The smaller diameter of the LAMS served to fix the intervening esophageal stent in position. Then contrast freely passed into the proximal duodenum.
Extracellular Vesicles and the Application of System Biology and Computational Modeling in Cardiac Repair
Authors: Venkata Naga Srikanth Garikipati, Farnaz Shoja-Taheri, Michael E. Davis, Raj Kishore
Journal: Circulation Research (2018)

Recent literature suggests that extracellular vesicles (EVs), secreted from most cells and containing cell-specific cargo of proteins, lipids, and nucleic acids, are major driver of intracellular communication in normal physiology and pathological conditions. The recent evidence on stem/progenitor cell EVs as potential therapeutic modality mimicking their parental cell function is exciting because EVs could possibly be used as a surrogate for the stem cell-based therapy, and this regimen may overcome certain roadblocks identified with the use of stem/progenitor cell themselves. This review provides a comprehensive update on our understanding on the role of EVs in cardiac repair and emphasizes the applications of stem/progenitor cell-derived EVs as therapeutics and discusses the current challenges associated with the EV therapy.
Síndrome de “Buried bumper”: prevalencia, presentación y pronóstico de esta complicación endoscópica
Authors: YP García De La Rosa, L De Castro Parga, JR Pineda, F Domínguez, L Cid, P Estévez, A Rincón, B Romero, N Quintans, I Rodríguez-Prada
Journal: Endoscopy (2017)

El síndrome de “Buried bumper” es una complicación grave por compresión del tope interno sobre la mucosa gástrica que se presenta en el 0,3 – 2,4% de las gastrostomías endoscópicas percutáneas (GEP). La triada típica es pérdida de permeabilidad, fugas e incapacidad para movilizar la sonda. La gastroscopia está indicada siempre que se sospeche y el método de liberación depende del tipo y la profundidad del tope interno de la GEP (técnica de disección, dilatador de Savary, técnica push-pull T o técnica de NOTES).
Abstract 12759: Effect of the Affinity of Myofilaments for Ca2+ on Ca2+ Wave Propagation in Intact Rat Cardiac Trabeculae
Authors: Masahito Miura, Mai Sasaki, Tsuyoshi Nagano, Chiyohiko Shindoh
Journal: Circulation (2013)

Background: The propagation velocity (Vp) of Ca2+ waves determines delayed afterdepolarization and affects the occurrence of arrhythmias in cardiac muscle. Muscle stretch causes ROS production by N...
Revisiting IL-2: Biology and therapeutic prospects
Authors: Abul K. Abbas, Eleonora Trotta, Dimitre R. Simeonov, Alexander Marson, Jeffrey A. Bluestone
Journal: Science Immunology (2018)

Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell growth factor essential for the proliferation of T cells and the generation of effector and memory cells. On the basis of this activity, the earliest therapeutic application of IL-2 was to boost immune responses in cancer patients. Therefore, it was a surprise that genetic deletion of the cytokine or its receptor led not only to the expected immune deficiency but also to systemic autoimmunity and lymphoproliferation. Subsequent studies established that IL-2 is essential for the maintenance of Foxp3+ regulatory T cells (Treg cells), and in its absence, there is a profound deficiency of Treg cells and resulting autoimmunity. We now know that IL-2 promotes the generation, survival, and functional activity of Treg cells and thus has dual and opposing functions: maintaining Treg cells to control immune responses and stimulating conventional T cells to promote immune responses. It is well documented that certain IL-2 conformations result in selective targeting of Treg cells by increasing reliance on CD25 binding while compromising CD122 binding. Recent therapeutic strategies have emerged to use IL-2, monoclonal antibodies to IL-2, or IL-2 variants to boost Treg cell numbers and function to treat autoimmune diseases while dealing with the continuing challenges to minimize the generation of effector and memory cells, natural killer cells, and other innate lymphoid populations.