tbuckley/cabot-search huggingface dataset:
Transplantation of Homologous and Heterologous Lymphoid Cells in X-Irradiated and Non-irradiated Mice
Authors: O. Vos, M.J. de Vries, J.C. Collenteur, D.W. van Bekkum
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Transplantation of Homologous and Heterologous Lymphoid Cells in X-Irradiated and Non-irradiated Mice Get access O. Vos, O. Vos Medical Biological Laboratory of the National Defense Research Council TNO, Rijswijk Z.H., Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. de Vries, M. J. de Vries Medical Biological Laboratory of the National Defense Research Council TNO, Rijswijk Z.H., Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar J. C. Collenteur, J. C. Collenteur Medical Biological Laboratory of the National Defense Research Council TNO, Rijswijk Z.H., Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar D. W. van Bekkum D. W. van Bekkum Medical Biological Laboratory of the National Defense Research Council TNO, Rijswijk Z.H., Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 23, Issue 1, July 1959, Pages 53–73, https://doi.org/10.1093/jnci/23.1.53 Published: 01 July 1959 Article history Received: 28 November 1958 Published: 01 July 1959
Circulating ectosomes: Determination of angiogenic microRNAs in type 2 diabetes
Authors: Ewa Ł. Stępień, Martyna Durak-Kozica, Agnieszka Kamińska, Marta Targosz-Korecka, Marcin Libera, Grzegorz Tylko, Agnieszka Opalińska, Maria Kapusta, Bogdan Solnica, Adriana Georgescu, Marina C. Costa, Agnieszka Czyżewska-Buczyńska, Wojciech Witkiewicz, Maciej T. Małecki, Francisco J. Enguita
Journal: Theranostics (2018)

Ectosomes (Ects) are a subpopulation of extracellular vesicles formed by the process of plasma membrane shedding. In the present study, we profiled ectosome-specific microRNAs (miRNAs) in patients with type 2 diabetes mellitus (T2DM) and analyzed their pro- and anti-angiogenic potential. Methods: We used different approaches for detecting and enumerating Ects, including atomic force microscopy, cryogenic transmission electron microscopy, and nanoparticle tracking analysis. Furthermore, we used bioinformatics tools to analyze functional data obtained from specific miRNA enrichment signatures during angiogenesis and vasculature development. Results: Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls. Conclusion: Our results showed differences in the abundance of pro- and anti-angiogenic miRNAs in Ects of patients with T2DM, and are suggestive of mechanisms underlying the development of vascular complications due to impaired angiogenesis in such patients.
International surveillance networks and principles of collaboration
Authors: I. S.T. Fisher, O N Gill
Journal: Eurosurveillance (2001)

(on behalf of the Enter-net participants) In the face of the multiplication and the development of international surveillance networks for communicable diseases, many questions on the transmission of personal data and information arise. The confidential nature of shared data and their disclosure internationally within and outside the network are therefore potential sources for conflicts. To resolve these problems, Enter-net developed its 'Collaboration Principles' intended to apply to all the participants of the network and to all others potentially involved. These principles propose solutions to questions related to the access to databases created within the framework of the network, to the quality and confidentiality of circulating data, to the individual responsibility in the identification of an incriminated product in case of an outbreak, and even to the transmission of information outside the network. These principles, which are to be regularly reviewed, are primarily aimed at optimising early detection and management of foodborne outbreaks, and at taking the necessary measures for public health. Considering the nature of the problems, however, some of these principles are also of relevance to other surveillance networks. (on behalf of the Enter-net participants)
Reduced-intensity conditioning for hematopoietic cell transplant for HLH and primary immune deficiencies
Authors: Carl E. Allen, Rebecca Marsh, Peter Dawson, Catherine M. Bollard, Shalini Shenoy, Philip Roehrs, Rabi Hanna, Lauri Burroughs, Leslie Kean, Julie-An Talano, Kirk R. Schultz, Sung-Yun Pai, K. Scott Baker, Jeffrey R. Andolina, Elizabeth O. Stenger, James Connelly, Alyssa Ramirez, Christopher Bryant, Mary Eapen, Michael A. Pulsipher
Journal: Blood (2018)
Oxygenating the way for enhanced chemophototherapy
Authors: Wen Jiang, Ian Michael Delahunty, Jin Xie
Journal: Theranostics (2018)

Hypoxia is behind tumor resistance in both chemotherapy and photodynamic therapy.This editorial highlights a study by Cai et al. [12] that a hemoglobin and human serum albumin hybrid protein nanoparticle can simultaneously deliver O 2 , chemotherapeutics, and photosensitizers to tumors for enhanced chemophototherapy.
Abstract 951: Femoral Plaques Confound the Association of Circulating Oxidized Low-density Lipoprotein with Carotid Atherosclerosis in a General Population Aged 35–55 Years (Asklepios Study).
Authors: Ernst Rietzschel, Michel Langlois, Marc De Buyzere, Dirk De Bacquer, Sofie Bekaert, Victor Blaton, Guy De Backer, Thierry Gillebert
Journal: Circulation (2008)

Objective. Previously reported associations of oxidized low-density lipoprotein (OxLDL) with non-invasive measures of atherosclerosis were inconsistent. Moreover oxLDL was not an independent predictor of future cardiovascular endpoints in models adjusting for lipid markers (total and HDL-cholesterol). Therefore, in the Asklepios Study cohort of 2524 asymptomatic subjects aged 35–55 years, we evaluated the multiple-adjusted association between circulating OxLDL and subclinical atherosclerosis in the carotid and femoral arteries (ultrasound based definitions). Methods and results. Participants (mean age 45 years, 51.5% females) underwent a clinical examination, ultrasound protocol for determination of intima-media thickness (IMT) and plaques (Mannheim criteria) in the left and right carotid and femoral arteries, blood analysis for OxLDL (mAb-4E6) and other risk markers. They all completed a lifestyle variables study questionnaire. OxLDL concentrations were highest in subjects with femoral plaques (n=658). In the group of subjects with carotid plaques (n=476), elevated OxLDL concentrations were related to concomitant femoral plaques detected in 54% of these subjects. Stepwise multiple regression for oxLDL comprizing classical covariates demonstrated that non-HDL-cholesterol (beta 0.41), HDL-cholesterol (beta −0.34), femoral artery plaque (beta 8.97), ln(triglycerides) (beta 4.89), and gender (beta 2.79) were significant (p &lt; 0.05) determinants. Full models including all appropriate anthropometric, hemodynamic, biochemical, and lifestyle variables confirmed that femoral plaques are independently related to OxLDL. Similar analyses demonstrated that femoral IMT, carotid IMT, or carotid plaques were not independently associated with OxLDL. Conclusion. Circulating OxLDL is independently associated with femoral plaque and not with carotid artery wall damage.
Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension
Authors: Pierre-Simon Bellaye, Toyoshi Yanagihara, Elise Granton, Seidai Sato, Chiko Shimbori, Chandak Upagupta, Jewel Imani, Nathan Hambly, Kjetil Ask, Jack Gauldie, Marc Iglarz, Martin Kolb
Journal: European Respiratory Journal (2018)

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with an unknown cause. Two drugs, nintedanib and pirfenidone, have been shown to slow, but not stop, disease progression. Pulmonary hypertension (PH) is a frequent complication in IPF patients and is associated with poor prognosis. Macitentan is a dual endothelin receptor antagonist that is approved for pulmonary arterial hypertension treatment. We hypothesised that using macitentan to treat animals with pulmonary fibrosis induced by adenoviral vector encoding biologically active transforming growth factor-β1 (AdTGF-β1) would improve the PH caused by chronic lung disease and would limit the progression of fibrosis. Rats (Sprague Dawley) which received AdTGF-β1 were treated by daily gavage of macitentan (100 mg·kg −1 ·day −1 ), pirfenidone (0.5% food admix) or a combination from day 14 to day 28. Pulmonary artery pressure (PAP) was measured before the rats were killed, and fibrosis was subsequently evaluated by morphometric measurements and hydroxyproline analysis. AdTGF-β1 induced pulmonary fibrosis associated with significant PH. Macitentan reduced the increase in PAP and both macitentan and pirfenidone stopped fibrosis progression from day 14 to day 28. Macitentan protected endothelial cells from myofibroblast differentiation and apoptosis whereas pirfenidone only protected against fibroblast-to-myofibroblast differentiation. Both drugs induced apoptosis of differentiated myofibroblasts in vitro and in vivo . Our results demonstrate that dual endothelin receptor antagonism was effective in both PH and lung fibrosis whereas pirfenidone only affected fibrosis.
Measurable residual disease, conditioning regimen intensity, and age predict outcome of allogeneic hematopoietic cell transplantation for acute myeloid leukemia in first remission: A registry analysis of 2292 patients by the Acute Leukemia Working Party European Society of Blood and Marrow Transplantation
Authors: Maria H. Gilleece, Myriam Labopin, Ibrahim Yakoub‐Agha, Liisa Volin, Gerard Socié, Per Ljungman, Anne Huynh, Eric Deconinck, Depei Wu, Jean Henri Bourhis, Jean Yves Cahn, Emmanuelle Polge, Mohamad Mohty, Bipin N. Savani, Arnon Nagler
Journal: American Journal of Hematology (2018)

Abstract Patients with acute myeloid leukemia (AML) in morphological first complete remission (CR1) pre‐allogeneic hematopoietic cell transplantation (HCT) may have measurable residual disease (MRD) by molecular and immunophenotyping criteria. We assessed interactions of MRD status with HCT conditioning regimen intensity in patients aged &lt;50 years (y) or ≥50y. This was a retrospective study by the European Society for Blood and Marrow Transplantation registry. Patients were &gt;18y with AML CR1 MRD NEG/POS and recipients of HCT in 2000‐2015. Conditioning regimens were myeloablative (MAC), reduced intensity (RIC) or non‐myeloablative (NMA). Outcomes included leukemia free survival (LFS), overall survival (OS), relapse incidence (RI), non‐relapse mortality (NRM), chronic graft‐vs‐host (cGVHD), and GVHD‐free and relapse‐free survival (GRFS). The 2292 eligible patients were categorized into four paired groups: &lt;50y MRD POS MAC ( N = 240) vs RIC/NMA ( N = 58); &lt;50y MRD NEG MAC ( N = 665) vs RIC/NMA ( N = 195); ≥50y MRD POS MAC ( N = 126) vs RIC/NMA ( N = 230), and ≥50y MRD NEG MAC ( N = 223) vs RIC/NMA ( N = 555). In multivariate analysis RIC/NMA was only inferior to MAC for patients in the &lt;50y MRD POS group, with worse RI (HR 1.71) and LFS (HR 1.554). Patients &lt;50Y MRD NEG had less cGVHD after RIC/NMA HCT (HR 0.714). GRFS was not significantly affected by conditioning intensity in any group. Patients aged &lt;50y with AML CR1 MRD POS status should preferentially be offered MAC allo‐HCT. Prospective studies are needed to address whether patients with AML CR1 MRD NEG may be spared the toxicity of MAC regimens. New approaches are needed for ≥50y AML CR1 MRD POS.
Abstract 17984: Abnormal Transient Ischemic Dilation Ratio with Regadenoson Myocardial Perfusion Imaging Does Not Predict Severe and Extensive Coronary Artery Disease
Authors: Henry A Tran, Scott Vasher, Parin Parikh, Lawrence Phillips
Journal: Circulation (2012)

Objectives: An abnormal transient ischemic ratio has been shown to be a clinically useful marker for severe and extensive coronary artery disease (S+E CAD) in many different myocardial perfusion im...
Abstract 14173: Depletion of Neutrophils Ablates Cardiac Ruptures after Treatment with TWEAK (Tumor Necrosis Factor-Like Weak Inducer of Apoptosis) in a Mouse Model of Myocardial Infarction
Authors: Christina Pachel, Barbara Bayer, Charlotte Dienesch, Denise Mathes, Helga Wagner, Sandra Umbenhauer, Wolfram Heitzmann, Steffen Salzmann, Georg Ertl, Harald Wajant, Stefan Frantz
Journal: Circulation (2012)

Introduction: Many processes regulated by TNF-like weak inducer of apoptosis (TWEAK) have been implicated in the development of cardiac dysfunction, but the role of TWEAK in healing and remodelling...
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary
Authors: Paul K. Whelton, Robert M. Carey, Wilbert S. Aronow, Donald E. Casey, Karen J. Collins, Cheryl Dennison Himmelfarb, Sondra M. DePalma, Samuel Gidding, Kenneth A. Jamerson, Daniel W. Jones, Eric J. MacLaughlin, Paul Muntner, Bruce Ovbiagele, Sidney C. Smith, Crystal C. Spencer, Randall S. Stafford, Sandra J. Taler, Randal J. Thomas, Kim A. Williams, Jeff D. Williamson, Jackson T. Wright
Journal: Journal of the American College of Cardiology (2017)
Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome
Authors: Vittorio Pengo, Gentian Denas, Giacomo Zoppellaro, Seena Padayattil Jose, Ariela Hoxha, Amelia Ruffatti, Laura Andreoli, Angela Tincani, Caterina Cenci, Domenico Prisco, Tiziana Fierro, Paolo Gresele, Arturo Cafolla, Valeria De Micheli, Angelo Ghirarduzzi, Alberto Tosetto, Anna Falanga, Ida Martinelli, Sophie Testa, Doris Barcellona, Maria Gerosa, Alessandra Banzato
Journal: Blood (2018)
Building Good Policy From Good Science—The Case for Concussion and Chronic Traumatic Encephalopathy
Authors: Christopher C. Giza, William Stewart, Mayumi L. Prins
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Eficacia, utilidad y seguridad de la retroflexión en colon derecho para la detección de lesiones colónicas no visualizadas mediante visión frontal
Authors: Ó Nogales, R Borobia, L Carrión, E Martos, J De La Maza, C De Gracia, M López-Ibáñez, L Lucendo, J García-Lledó, L Pérez-Carazo
Journal: Endoscopy (2017)

la retroflexión en colon derecho (RCD) parece aumentar la tasa de detección de adenomas (TDA), siendo tanto el éxito como utilidad de esta maniobra variable en la literatura.
Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms
Authors: Robert Albero, Anna Enjuanes, Santiago Demajo, Giancarlo Castellano, Magda Pinyol, Noelia García, Cristina Capdevila, Guillem Clot, Helena Suárez-Cisneros, Mariko Shimada, Kennosuke Karube, Mónica López-Guerra, Dolors Colomer, Sílvia Beà, José Ignacio Martin-Subero, Elías Campo, Pedro Jares
Journal: Journal of Clinical Investigation (2018)

Cyclin D1 is an oncogene frequently overexpressed in human cancers that has a dual function as cell cycle and transcriptional regulator, although the latter is widely unexplored. Here, we investigated the transcriptional role of cyclin D1 in lymphoid tumor cells with cyclin D1 oncogenic overexpression. Cyclin D1 showed widespread binding to the promoters of most actively transcribed genes, and the promoter occupancy positively correlated with the transcriptional output of targeted genes. Despite this association, the overexpression of cyclin D1 in lymphoid cells led to a global transcriptional downmodulation that was proportional to cyclin D1 levels. This cyclin D1–dependent global transcriptional downregulation was associated with a reduced nascent transcription and an accumulation of promoter-proximal paused RNA polymerase II (Pol II) that colocalized with cyclin D1. Concordantly, cyclin D1 overexpression promoted an increase in the Poll II pausing index. This transcriptional impairment seems to be mediated by the interaction of cyclin D1 with the transcription machinery. In addition, cyclin D1 overexpression sensitized cells to transcription inhibitors, revealing a synthetic lethality interaction that was also observed in primary mantle cell lymphoma cases. This finding of global transcriptional dysregulation expands the known functions of oncogenic cyclin D1 and suggests the therapeutic potential of targeting the transcriptional machinery in cyclin D1–overexpressing tumors.
Recurrence rates in primary spontaneous pneumothorax: a systematic review and meta-analysis
Authors: Steven P. Walker, Anna C. Bibby, Paul Halford, Louise Stadon, Paul White, Nick A. Maskell
Journal: European Respiratory Journal (2018)

Primary spontaneous pneumothorax (PSP) recurrence rates vary widely in the published literature, with limited data describing the factors that influence recurrence. The aims of this systematic review were to determine an estimation of PSP recurrence rates and describe risk factors for recurrence.A systematic review was conducted of all studies reporting PSP recurrence. Electronic searches were performed to identify English language publications of randomised trials and observational studies. The population was adults with PSP, who underwent conservative management, pleural aspiration or chest drainage. The outcome of interest was recurrence. Articles were screened and data extracted from eligible studies by two reviewers.Of 3607 identified studies, 29 were eligible for inclusion, comprising 13 548 patients. Pooled 1-year and overall recurrence rates were 29.0% (95% CI 20.9-37.0%) and 32.1% (95% CI 27.0-37.2%), respectively. Female sex was associated with increased recurrence (OR 3.03, 95% CI 1.24-7.41), while smoking cessation was associated with a four-fold decrease in risk (OR 0.26, 95% CI 0.10-0.63). I2 for random effects meta-analysis was 94% (p<0.0001), reflecting high heterogeneity between studies.This systematic review demonstrates a 32% PSP recurrence rate, with greatest risk in the first year. Female sex was associated with higher risk, suggesting possible sex-specific pathophysiology.
A Multivariable Prediction Model for <i>Pneumocystis jirovecii</i> Pneumonia in Hematology Patients with Acute Respiratory Failure
Authors: Elie Azoulay, Antoine Roux, François Vincent, Achille Kouatchet, Laurent Argaud, Antoine Rabbat, Julien Mayaux, Pierre Perez, Frédéric Pène, Martine Nyunga, Fabrice Bruneel, Kada Klouche, Djamel Mokart, Michael Darmon, Sylvie Chevret, Virginie Lemiale
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

The incidence of Pneumocystis jirovecii pneumonia (PjP) is rising. Longer time to treatment is associated with higher mortality.To develop a multivariable risk prediction model for PjP diagnosis.In a prospective multicenter cohort of ICU patients with hematological malignancies and acute respiratory failure, factors associated with documented PjP were identified. The risk prediction model was tested in an independent prospective multicenter cohort. We assessed discrimination (by areas under the receiver operating characteristic curves [AUCs]) and goodness of fit (by Hosmer-Lemeshow statistics). Model performance was assessed using 30 sets of imputed data sets.Among the 1,330 patients, 134 of 1,092 (12.3%; 95% confidence interval [CI], 10.4-14.4%) had proven PjP in the derivation cohort, as did 15 of 238 (6.3%, 95% CI, 3.6-10.2%) in the validation cohort. The model included age, lymphoproliferative disease, anti-Pneumocystis prophylaxis, the number of days between respiratory symptom onset and ICU admission, shock, chest radiograph pattern, and pleural effusion. The median (interquartile range) score was 3.5 (1.5-5.0) (range, -3.5 to 8.5) in the derivation cohort and 1.0 (0-2.0) (range, -3.5 to 6.0) in the validation cohort. The best threshold was defined on the validation sample as 3, allowing us to reach 86.7% sensitivity and 67.7% specificity for PjP, with a negative predictive value of 97.9% in the case of 10% prevalence. The score had good calibration (goodness of fit, -0.75) and discrimination in the derivation cohort (mean AUC, 0.80; 95% CI, 0.76-0.84) and validation cohort (mean AUC, 0.83; 95% CI, 0.72-0.93).The PjP score for hematology patients with acute respiratory failure can be computed at admission, based on readily available variables. Potential clinical benefits of using this score deserve assessment.
European Antimicrobial Resistance Surveillance System (EARSS): objectives and organisation
Authors: S L A M Bronzwaer, W Goettsch, B Olsson-Liljequist, M C J Wale, A Vatopoulos, M. J.W Sprenger
Journal: Eurosurveillance (1999)

‘Effective European surveillance must have the agreement and active involvement of all participants’, concluded a European Union (EU) conference on the need for surveillance of resistant microorganisms (the microbial threat), held in September 1998 in De