tbuckley/cabot-search huggingface dataset:
Long-Term Prognostic Implications of Previous Silent Myocardial Infarction in Patients Presenting With Acute Myocardial Infarction
Authors: Raquel P. Amier, Martijn W. Smulders, Wiesje M. van der Flier, Sebastiaan C.A.M. Bekkers, Alwin Zweerink, Cornelis P. Allaart, Ahmet Demirkiran, Sebastiaan T. Roos, Paul F.A. Teunissen, Yolande Appelman, Niels van Royen, Raymond J. Kim, Albert C. van Rossum, Robin Nijveldt
Journal: JACC. Cardiovascular imaging (2018)

This study investigated the prevalence of silent myocardial infarction (MI) in patients presenting with first acute myocardial infarction (AMI), and its relation with mortality and major adverse cardiovascular events (MACE) at long-term follow-up.Up to 54% of MI occurs without apparent symptoms. The prevalence and long-term prognostic implications of previous silent MI in patients presenting with seemingly first AMI are unclear.A 2-center observational longitudinal study was performed in 392 patients presenting with first AMI between 2003 and 2013, who underwent late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) examination within 14 days post-AMI. Silent MI was assessed on LGE-CMR images by identifying regions of hyperenhancement with an ischemic distribution pattern in other territories than the AMI. Mortality and MACE (all-cause death, reinfarction, coronary artery bypass grafting, and ischemic stroke) were assessed at 6.8 ± 2.9 years follow-up.Thirty-two patients (8.2%) showed silent MI on LGE-CMR. Compared with patients without silent MI, mortality risk was higher in patients with silent MI (hazard ratio: 3.87; 95% confidence interval: 1.21 to 12.38; p = 0.023), as was risk of MACE (hazard ratio: 3.10; 95% confidence interval: 1.22 to 7.86; p = 0.017), both independent from clinical and infarction-related characteristics.Silent MI occurred in 8.2% of patients presenting with first AMI and was independently related to poorer long-term clinical outcome, with a more than 3-fold risk of mortality and MACE. Silent MI holds prognostic value over important traditional prognosticators in the setting of AMI, indicating that these patients represent a high-risk subgroup warranting clinical awareness.
Abstract 17205: Exercise Echocardiography Predicts Major Clinical Events in Patients With Significant Asymptomatic Mitral Regurgitation
Authors: Elizabeth Grier, Alexander Taylor, Vera Rigolin, Zhi Li, Adin-Cristian Andrei, Priya Kohli, Madeline Jankowski, Jyothy Puthumana
Journal: Circulation (2016)

Introduction:  Significant mitral regurgitation (MR) often results in progressive cardiac dysfunction that frequently requires surgical intervention. This study aims to assess the prognostic value of exercise stress echocardiography (ESE) in the evaluation of asymptomatic patients with significant MR.   Methods:  295 patients with predominantly organic, moderate-to-severe and severe MR underwent ESE. Baseline characteristics at the time of the stress test, exercise variables and echocardiographic parameters are shown in Table 1. We have evaluated the incidence of and identified risk factors for death and the following major clinical events (MCEs): atrial fibrillation (afib), pulmonary hypertension (pHTN), heart failure (HF), and stroke/TIA. Multivariable Cox regression models were used to identify demographic, echocardiographic and exercise parameters associated with MCEs.   Results:  Patients were followed for a median of 4.2 years (IQR 5.5) and 50% of them experienced at least one MCE. In this cohort, 23% of the patients underwent mitral valve surgery during the follow-up period. Longer exercise time was associated with a lower risk of HF/death (hazard ratio 0.88, 95% CI [0.81, 0.96]), as well as stroke/death (0.77 [0.71, 0.85]). A higher biplane ejection fraction (EF) also was associated with a lower risk of HF/death (0.95 [0.93, 0.98]). A higher baseline right ventricular systolic pressure (RVSP) was associated with a higher risk of pHTN/death (1.1 [1.0, 1.1]), while left atrial volume index (LAVI) greater than or equal to 48 mL/m 2  was associated with a higher risk of afib/death (2.4, [1.4, 4.1]).   Conclusions:  In asymptomatic patients with significant organic MR, there is a high incidence of heart valve disease-related MCEs. Higher LAVI, higher RVSP, and lower EF were associated with worse outcomes and could inform the process of earlier surgical referral.
Long term prognostic value of the FibroTest in patients with non-alcoholic-fatty-liver disease (NAFLD), compared to chronic hepatitis C (CHC), B (CHB), and alcoholic liver disease (ALD)
Authors: M. Munteanu, J. Moussalli, M. Rudler, P. Lebray, H. Perazzo, J. Massard, R. Pais, F. Charlotte, V. Thibault, L. Olivier, L. Hannoun, M.A. Valantin, Y. Ngo, F. Drane, F.I. Bismut, O. Deckmyn, C. Housset, D. Thabut, V. Ratziu, T. Poynard
Journal: Journal of Hepatology (2018)
Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds
Authors: Xi Tian, Michael E. Werner, Kyle C. Roche, Ariel D. Hanson, Henry P. Foote, Stephanie K. Yu, Samuel B. Warner, Jonathan A. Copp, Haydee Lara, Eliane L. Wauthier, Joseph M. Caster, Laura E. Herring, Longzhen Zhang, Joel E. Tepper, David S. Hsu, Tian Zhang, Lola M. Reid, Andrew Z. Wang
Journal: Nature Biomedical Engineering (2018)
The Sensitivity and Specificity of the Glucose Challenge Test in a Universal Two-Step Screening Strategy for Gestational Diabetes Mellitus Using the 2013 World Health Organization Criteria
Authors: Katrien Benhalima, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu
Journal: Diabetes Care (2018)

The International Association of Diabetes and Pregnancy Study Groups (IADPSG) recommends a universal one-step screening strategy with the 75-g oral glucose tolerance test (OGTT) for gestational diabetes mellitus (GDM) (1). Since the adoption of the IADPSG recommendation by the World Health Organization (WHO), the IADPSG criteria are commonly referred to as the 2013 WHO criteria (2). The IADPSG recommendation remains controversial due to the significant increase in GDM prevalence, increased workload, the need for a fasting test, and the risk for increased medicalization of care (3). Several professional associations therefore still recommend a universal two-step screening strategy, using a nonfasting 50-g glucose challenge test (GCT) to determine whether an OGTT should be performed (3). The GCT is easier to perform and is generally better tolerated than an OGTT. In addition, a two-step screening strategy with a GCT could limit the number of OGTTs. The GCT has been used in combination with the 100-g OGTT or the 75-g OGTT with various diagnostic criteria, but data are lacking on the sensitivity and specificity of the GCT in conjunction with the 2013 WHO criteria for GDM.

We performed a multicentric prospective cohort study, the Belgian Diabetes in Pregnancy Study (BEDIP-N), between 2014 and 2017, enrolling 2,006 women between 6 and 14 weeks of pregnancy (4). Participants without prediabetes or diabetes in early pregnancy (defined by …
TCTAP A-064 2-year Prognostic Effect of Uric Acid in Patients Underwent Percutaneous Coronary Intervention: A Large Observational Cohort Study in China
Authors: Ping Jiang, Yuejin Yang, Runlin Gao, Zhan Gao, Bo Xu, Jinqing Yuan
Journal: Journal of the American College of Cardiology (2018)
Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27
Authors: Heeju Ryu, Hoyong Lim, Garam Choi, Young-Jun Park, Minkyoung Cho, Hyeongjin Na, Chul Won Ahn, Young Chul Kim, Wan-Uk Kim, Sang-Hak Lee, Yeonseok Chung
Journal: Nature Immunology (2018)
MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer
Authors: Renée de Leeuw, Christopher McNair, Matthew J. Schiewer, Neermala Poudel Neupane, Lucas J. Brand, Michael A. Augello, Zhen Li, Larry C. Cheng, Akihiro Yoshida, Sean M. Courtney, E. Starr Hazard, Gary Hardiman, Maha H. Hussain, J. Alan Diehl, Justin M. Drake, Wm. Kevin Kelly, Karen E. Knudsen
Journal: Clinical Cancer Research (2018)

Purpose: Loss of cell-cycle control is a hallmark of cancer, which can be targeted with agents, including cyclin-dependent kinase-4/6 (CDK4/6) kinase inhibitors that impinge upon the G1-S cell-cycle checkpoint via maintaining activity of the retinoblastoma tumor suppressor (RB). This class of drugs is under clinical investigation for various solid tumor types and has recently been FDA-approved for treatment of breast cancer. However, development of therapeutic resistance is not uncommon.Experimental Design: In this study, palbociclib (a CDK4/6 inhibitor) resistance was established in models of early stage, RB-positive cancer.Results: This study demonstrates that acquired palbociclib resistance renders cancer cells broadly resistant to CDK4/6 inhibitors. Acquired resistance was associated with aggressive in vitro and in vivo phenotypes, including proliferation, migration, and invasion. Integration of RNA sequencing analysis and phosphoproteomics profiling revealed rewiring of the kinome, with a strong enrichment for enhanced MAPK signaling across all resistance models, which resulted in aggressive in vitro and in vivo phenotypes and prometastatic signaling. However, CDK4/6 inhibitor-resistant models were sensitized to MEK inhibitors, revealing reliance on active MAPK signaling to promote tumor cell growth and invasion.Conclusions: In sum, these studies identify MAPK reliance in acquired CDK4/6 inhibitor resistance that promotes aggressive disease, while nominating MEK inhibition as putative novel therapeutic strategy to treat or prevent CDK4/6 inhibitor resistance in cancer. Clin Cancer Res; 24(17); 4201-14. ©2018 AACR.
HBV RNA in serum is an early predictor for sustained immune control following treatment with pegylated interferon alfa in patients with HBeAg negative chronic hepatitis B
Authors: M. Farag, M.V. Campenhout, F. van Boemmel, V. Rijckborst, Y. Cakaloglu, P. Ferenci, F. Tabak, J. Feld, B. Hansen, H. Janssen
Journal: Journal of Hepatology (2018)
In vivo knockdown of Plk1 using a novel breakable mesoporous silica particle siRNA carrier reduces tumor growth in an orthotopic xenograft mouse model of hepatocellular carcinoma
Authors: François H.T. Duong, A. Saviano, E. Robinet, M. Dentinger, G.B. About, C. Thumann, T. Sorg-Guss, T. Baumert, L.D. Cola
Journal: Journal of Hepatology (2018)
Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1
Authors: Anna-Eliane Hopf, Christian Andresen, Sebastian Kötter, Małgorzata Isić, Kamila Ulrich, Senem Sahin, Sabine Bongardt, Wilhelm Röll, Felicitas Drove, Nina Scheerer, Leni Vandekerckhove, Gilles W. De Keulenaer, Nazha Hamdani, Wolfgang A. Linke, Martina Krüger
Journal: Circulation Research (2018)

Rationale: Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction associated with type-2 diabetes mellitus. However, the insulin-related signaling pathways that modify titin-based cardiomyocyte tension, thereby contributing to modulation of diastolic function, are largely unknown. Objective: We aimed to determine how impaired insulin signaling affects titin expression and phosphorylation and thus increases passive cardiomyocyte tension, and whether metformin or neuregulin-1 (NRG-1) can correct disturbed titin modifications and increased titin-based stiffness. Methods and Results: We used cardiac biopsies from human diabetic (n=23) and nondiabetic patients (n=19), cultured rat cardiomyocytes, left ventricular tissue from apolipoprotein E–deficient mice with streptozotocin-induced diabetes mellitus (n=12–22), and ZSF1 (obese diabetic Zucker fatty/spontaneously hypertensive heart failure F1 hybrid) rats (n=5–6) and analyzed insulin-dependent signaling pathways that modulate titin phosphorylation. Titin-based passive tension was measured using permeabilized cardiomyocytes. In human diabetic hearts, we detected titin hypophosphorylation at S4099 and hyperphosphorylation at S11878, suggesting altered activity of protein kinases; cardiomyocyte passive tension was significantly increased. When applied to cultured cardiomyocytes, insulin and metformin increased titin phosphorylation at S4010, S4099, and S11878 via enhanced ERK1/2 (extracellular signal regulated kinase 1/2) and PKCα (protein kinase Cα) activity; NRG-1 application enhanced ERK1/2 activity but reduced PKCα activity. In apolipoprotein E–deficient mice, chronic treatment of streptozotocin-induced diabetes mellitus with NRG-1 corrected titin phosphorylation via increased PKG (protein kinase G) and ERK1/2 activity and reduced PKCα activity, which reversed the diabetes mellitus–associated changes in titin-based passive tension. Acute application of NRG-1 to obese ZSF1 rats with type-2 diabetes mellitus reduced end-diastolic pressure. Conclusions: Mechanistically, we found that impaired cGMP–PKG signaling and elevated PKCα activity are key modulators of titin-based cardiomyocyte stiffening in diabetic hearts. We conclude that by restoring normal kinase activities of PKG, ERK1/2, and PKCα, and by reducing cardiomyocyte passive tension, chronic NRG-1 application is a promising approach to modulate titin properties in heart failure with preserved ejection fraction associated with type-2 diabetes mellitus.
Quantitation of Perfused Lung Volume Using Hybrid SPECT/CT Allows Refining the Assessment of Lung Perfusion and Estimating Disease Extent in Chronic Thromboembolic Pulmonary Hypertension
Authors: Thorsten Derlin, Catharina Kelting, Katja Hueper, Desiree Weiberg, Katrin Meyer, Karen M. Olsson, James T. Thackeray, Tobias Welte, Frank M. Bengel, Marius M. Hoeper
Journal: Clinical Nuclear Medicine (2018)

Background We evaluated the feasibility of perfusion SPECT/CT for providing quantitative data for estimation of perfusion defect extent in chronic thromboembolic pulmonary hypertension (CTEPH). Methods Thirty patients with CTEPH underwent 99m Tc–human serum albumin lung perfusion SPECT/CT. Perfusion defects were quantified using 3 different methods: (1) visual, semiquantitative scoring of perfusion defect extent in each lung segment, (2) threshold-based segmentation of perfused lung volumes, and (3) threshold-based segmentation of perfused lung volumes divided by segmented lung volumes at CT (perfusion index). Imaging findings were correlated with right-sided heart catheterization results and N-terminal pro–B-type natriuretic peptide. Receiver operating characteristic analysis was performed to identify SPECT thresholds for mean pulmonary arterial pressure (PAPm) greater than 50 mm Hg. Results Assessment of lung perfusion provided similar results using all 3 methods. The perfusion defect score correlated with PAPm ( r s = 0.60, P = 0.0005) and was associated with serum levels of N-terminal pro–B-type natriuretic peptide ( r s = 0.37, P = 0.04). Perfused lung volume (40% threshold, r s = −0.48, P = 0.007) and perfusion index (40% threshold, r s = −0.50, P = 0.005) decreased as PAPm increased. Receiver operating characteristic analysis showed that perfusion defect score (sensitivity, 88%; specificity, 77%; area under the curve [AUC] = 0.89, P = 0.001), perfused lung volume (sensitivity, 88%; specificity, 64%; AUC = 0.80, P = 0.01), and perfusion index (sensitivity, 88%; specificity, 64%; AUC = 0.82, P = 0.009) could identify patients with PAPm of greater than 50 mm Hg. Conclusions Quantitative analysis of perfusion defects at SPECT is feasible, provides a measure of disease severity, and correlates with established clinical parameters. Quantitation of perfusion SPECT may refine the diagnostic approach in CTEPH providing a quantitative imaging biomarker, for example, for therapy monitoring.
Gemcitabine, nab-paclitaxel, cisplatin, and anakinra (AGAP) treatment in patients with localized pancreatic ductal adenocarcinoma (PDAC).
Authors: Carlos Becerra, Andrew Scott Paulson, Keith M Cavaness, Scott A. Celinski
Journal: Journal of Clinical Oncology (2018)

449 Background: Treatment options for localized PDAC include surgery, chemo- and radio-therapy. Inflammatory stimuli cause IL-1 release and mediate inflammatory and immunological responses. PDAC cells can induce secretion of IL-1β which facilitates tumor development and progression. We showed that anakinra, a recombinant, non-glycosylated form of the human interleukin-1 receptor antagonist, when given with FOLFIRINOX, was safe for use in metastatic PDAC. Herein we report the preliminary results of AGAP in patients with non-metastatic PDAC. Methods: 16 patients with non-metastatic PDAC were treated with AGAP on Day 1 and 8 of a 21 day cycle for up to 6 cycles. Patients self-administered anakinra a day after their first dose of chemotherapy (100 mg every other day; SC). Restaging scans evaluation was performed after every 2 cycles. Patients filled a QOL questionnaire once a month and serum was collected at baseline and at defined time points for biomarker analysis. Results: Grade 3/4 toxicities: neutropenia (50%), alopecia (13%), anemia (25%), thrombocytopenia (19%), diarrhea (19%), hypomagnesemia (13%), vomiting (13%), and 6% of patients, respectively had febrile neutropenia, nausea, hypocalcemia, and erythema at the injection sites. Twelve patients had surgery and all had negative margins in the pathology specimen. Ten patients had normal CA19-9 prior to resection and 3 had disease recurrence. Two patients had elevated CA19-9 prior to surgery and 1 patient had disease recurrence. Four patients did not have surgery; 3 received XRT and had disease progression and 1 patient declined further therapy and expired on hospice. No patients had systemic progression while on AGAP chemotherapy. Eight patients are alive without recurrence at a median follow up of 13 months. Conclusions: AGAP was tolerable with expected toxicities from the combination regimen. Biomarker analysis, disease recurrence and survival will be updated at the meeting. The study has been expanded to include additional patients. Clinical trial information: NCT02550327.
TCTAP C-164 Endovascular Treatment of Thoracic Aortic Arch Aneurysm: Using Window Shaped Fenestrated Stent Graft
Authors: Sun Hack Lee, Han Cheol Lee, Jeong Cheon Choe, Jinhee Ahn, Jin Sup Park, Hye Won Lee, Jun-Hyok Oh, Jung Hyun Choi, Kwang Soo Cha, Taek Jong Hong
Journal: Journal of the American College of Cardiology (2018)
Warty Fingers and Toes in a Child With Congenital Lymphedema
Authors: Anuradha Bishnoi, Keshavamurthy Vinay, Vikarn Vishwajeet, Uma Nahar Saikia, Inusha Panigrahi, Muthu Sendhil Kumaran
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Circulating NK cells in cirrhosis are hypofunctional, with an expanded inhibitory liver-homing CD56dimCD16+/− NK cell population
Authors: N. Kumar, W. Khamri, F. Sadiq, E. Triantafyllou, F. Lebossé, M. Sujit, A. Dhar, M. Thursz, H. Antoniades, S. Khakoo
Journal: Journal of Hepatology (2018)
Characterization of miR deregulation in cholangiocarcinoma (CCA): Consequences in tumor heterogeneity and drug resistance
Authors: P. Munoz-Garrido, L. Satriano, D. Høgdall, J. Banales, A. Ghazal, C.O. Rourke, J. Andersen, J. Marquardt
Journal: Journal of Hepatology (2018)
Endoscopist factors that influence serrated polyp detection: a multicenter study
Authors: Seth Crockett, Rebecca Gourevitch, Michele Morris, David Carrell, Sherri Rose, Zhuo Shi, Julia Greer, Robert Schoen, Ateev Mehrotra
Journal: Endoscopy (2018)

Abstract Background Serrated polyps are important colorectal cancer precursors that are variably detected during colonoscopy. We measured serrated polyp detection rate (SPDR) in a large, multicenter, cross-sectional study of colonoscopy quality to identify drivers of SPDR variation. Methods Colonoscopy and pathology reports were collected for a 2-year period (10/2013-9/2015) from four sites across the United States. Data from reports, including size, location, and histology of polyps, were abstracted using a validated natural language processing algorithm. SPDR was defined as the proportion of colonoscopies with ≥ 1 serrated polyp (not including hyperplastic polyps). Multivariable logistic regression was performed to determine endoscopist characteristics associated with serrated polyp detection. Results A total of 104 618 colonoscopies were performed by 201 endoscopists who varied with respect to specialty (86 % were gastroenterologists), sex (18 % female), years in practice (range 1 – 51), and number of colonoscopies performed during the study period (range 30 – 2654). The overall mean SPDR was 5.1 % (SD 3.8 %, range 0 – 18.8 %). In multivariable analysis, gastroenterology specialty training (odds ratio [OR] 1.89, 95 % confidence interval [CI] 1.33 – 2.70), fewer years in practice (≤ 9 years vs. ≥ 27 years: OR 1.52, 95 %CI 1.14 – 2.04)], and higher procedure volumes (highest vs. lowest quartile: OR 1.77, 95 %CI 1.27 – 2.46)] were independently associated with serrated polyp detection. Conclusions Gastroenterology specialization, more recent completion of training, and greater procedure volume are associated with serrated polyp detection. These findings imply that both repetition and training are likely to be important contributors to adequate detection of these important cancer precursors. Additional efforts to improve SPDR are needed.
The Return of Duck and Cover and the Imminence of Death—What It Means for Physicians
Authors: Mary E. Woesner
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal