tbuckley/cabot-search huggingface dataset:
Insulin vs Glyburide for Gestational Diabetes
Authors: Donald R. Coustan, Linda Barbour
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 381: Ex vivo Heart Function Analysis in Adult Zebrafish
Authors: Alexey V Dvornikov, Hong Zhang, Xiaolei Xu
Journal: Circulation Research (2017)

Zebrafish ( Danio rerio ) is an efficient vertebrate model of human cardiomyopathy which is amenable to the medium throughput screening approaches opening opportunities to search new genetic modifiers via mutagenesis screening and assessing compound-based therapies at larger scale. The advent of genome editing technology enables the generation of a panel of genetic models of cardiomyopathy with mutations in leading cardiomyopathy genes. However, one of the major bottlenecks for adult zebrafish as a cardiomyopathy model is the lack of appropriate cardiac functional assays. Due to small heart size, in vivo methods such as those based on echocardiography, are limited by their insufficient resolution. Here, we report the development of an ex vivo approach aimed to facilitate phenotyping in adult zebrafish. We show that our method is able to quantify parameters of pump function of the heart, including end-diastolic/systolic length/volumes, ejection and shortening fractions, and velocities of contraction/relaxation. We defined the basic parameters of these indices using different wild-type strains, age, and sex, and then demonstrated that our method can be useful in definition of progression of pathogenesis of both acquired (doxorubicin-injected) and inherited cardiomyopathy models. We conclude that our novel approach shall facilitate cardiac phenotyping in adult zebrafish models of heart diseases.
Hepatitis C treatment success in primary and tertiary care among people with HCV/HIV coinfection
Authors: J. Doyle, D. Iser, J. Sasadeusz, J. Roney, J. Cutts, A. Bowring, R. Winter, M. O’reilly, C. Fairley, E. Gane, J. Hoy, G. Matthews, N. Medland, R. Moore, M. Prins, B. Tee, M. Stoove, M. Hellard
Journal: Journal of Hepatology (2018)
Capillary Hemangioma as an Unusual Cause of Doughnut Sign on Bone Scan
Authors: Omar Q. Samarah, Mohammad I. Tayyem, Nisreen Abu shahin, Ghadeer AlMuhaisen, Malik E. Juweid
Journal: Clinical Nuclear Medicine (2018)

A 28-year-old woman presented with a mass in her right leg, which, on plain radiograph, appeared as a lytic lesion in the mid-shaft of the tibia with cortical thinning but without periosteal reaction. Tc-MDP 3-phase bone scan demonstrated intense uptake in the periphery of the mass with a photopenic center, the so-called doughnut sign. Histopathology revealed a capillary hemangioma. This case demonstrates that the doughnut sign on bone scan can be caused by capillary hemangioma in addition to other reported bone pathologies, including aneurysmal bone cyst, giant cell tumor, and telangiectatic osteosarcoma.
Abstract 14830: Early Coronary Angiography Is Associated With Improved 30-day Survival in Out-of-hospital Cardiac Arrest Patients Without ST-elevation on First Ecg
Authors: Ludvig Elfwén, Rickard Lagedal, Martin Jonsson, Jacob Hollenberg, Ulf Jensen, Mattias Ringh, Leif Svensson, Sten Rubertsson, Stefan James, Per Nordberg
Journal: Circulation (2016)

Background and Aim:  Observational studies have shown high rates of acute coronary occlusions in OHCA patients despite the absence of ST -elevation on ECG. Current guidelines emphasize the need for urgent coronary angiography (CAG) after an OHCA. However, there is a lack of evidence for this strategy and data from previous observational studies is conflicting regarding the benefit of early CAG in these patients.  The aim of this registry-based study was to investigate whether early CAG after OHCA is associated with improved 30-day survival in patients without ST-elevation on ECG after return of spontaneous circulation.   Methods:  An observational study based on prospectively collected data from the Swedish cardiac arrest and the SWEDEHEART registries during 2008-2013. Patients included were those with bystander witnessed OHCAs, age 18 to 80 years, ventricular fibrillation as first rhythm, admitted alive at hospital, unconscious (i.e. Glasgow Coma scale ≤ 8). Patients with ST-elevation or presumed new left bundle branch block on first ECG were excluded.  Patients were divided into two groups; early CAG (within 24 hours after admission) versus late or no CAG. Primary endpoint was 30-day survival. The logistic regression analysis included gender, age, bystander CPR, location of the arrest (i.e. home vs outside home) and presumed cardiac cause.   Results:  In total, 885 OHCA cases with ventricular fibrillation as first rhythm and ECG without ST-elevation were included in this survey. Among them, 229 patients (26%) received early CAG and 656 (74%) late or no CA. The 30-day survival rate was 66,8% in patients receiving early CAG versus 49,4% with late or no CAG. In the multivariate analysis the adjusted odds ratio for 30-day survival was OR 1,95 in the group that received early CAG (95% CI 1,33-2,85 p   Conclusions:  In this population with witnessed OHCA, ventricular fibrillation as first rhythm and ECG without ST-elevation, early coronary angiography performed within 24 hours was associated with improved 30-day survival. There is an urgent need for randomized trials to confirm this finding. A Swedish national randomized controlled trial was started during 2015 to address this issue (Clinicaltrial id: NCT02309151).
Safety and effectiveness of DAA treatment and clinical outcomes of HCV liver transplanted patients with recurrent hepatitis C infection: a single center 3-year study from Italy
Authors: F. Invernizzi, M.F. Donato, S. Monico, M. Borghi, D. Dondossola, B. Antonelli, G. Lunghi, R. Perbellini, F. Fabrizi, G. Rossi, P. Lampertico
Journal: Journal of Hepatology (2018)
Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy
Authors: Kathleen Lee-Sarwar, Rachel S. Kelly, Jessica Lasky-Su, D. Branch Moody, Alex R. Mola, Tan-Yun Cheng, Laurie E. Comstock, Robert S. Zeiger, George T. O'Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Nancy Laranjo, Diane R. Gold, Supinda Bunyavanich, Jessica H. Savage, Scott T. Weiss, Patrick J. Brennan, Augusto A. Litonjua
Journal: Journal of Allergy and Clinical Immunology (2018)
Preventability of Early Versus Late Hospital Readmissions in a National Cohort of General Medicine Patients
Authors: Kelly L. Graham, Andrew D. Auerbach, Jeffrey L. Schnipper, Scott A. Flanders, Christopher S. Kim, Edmondo J. Robinson, Gregory W. Ruhnke, Larissa R. Thomas, Sunil Kripalani, Eduard E. Vasilevskis, Grant S. Fletcher, Neil J. Sehgal, Peter K. Lindenauer, Mark V. Williams, Joshua P. Metlay, Roger B. Davis, Julius Yang, Edward R. Marcantonio, Shoshana J. Herzig
Journal: Annals of Internal Medicine (2018)

Many experts believe that hospitals with more frequent readmissions provide lower-quality care, but little is known about how the preventability of readmissions might change over the postdischarge time frame.
Obinutuzumab plus bendamustine in previously untreated patients with CLL: a subgroup analysis of the GREEN study
Authors: Stephan Stilgenbauer, Veronique Leblond, Robin Foà, Sebastian Böttcher, Osman Ilhan, Wolfgang Knauf, Eva Mikuskova, Christoph Renner, Eugen Tausch, Dariusz Woszczyk, Ekaterina Gresko, Linda Lundberg, Tom Moore, Thea Morris, Susan Robson, Francesc Bosch
Journal: Leukemia (2018)

GREEN (NCT01905943) is a non-randomized, open-label phase IIIb study investigating obinutuzumab alone or plus chemotherapy in chronic lymphocytic leukemia (CLL). We report a preplanned subgroup analysis of 158 previously untreated CLL patients receiving obinutuzumab-bendamustine (G-B). Patients received six 28-day cycles (C) of G-B: obinutuzumab day (D)1/D2 of C1 (25 mg D1/975 mg D2), 1000 mg D8 and D15 of C1, and D1 of C2-6; and bendamustine 70/90 mg/m2 D1 and D2 of C1-6. The primary endpoint was safety/tolerability. Grade ≥3 adverse events (AEs) occurred in 82.3% of patients, including neutropenia (49.4%), thrombocytopenia (12.0%) and febrile neutropenia (10.8%). Serious AEs included neutropenia (12.7%), febrile neutropenia (9.5%) and pneumonia (7.6%). Rates of grade ≥3 infections and infusion-related reactions were 20.3% and 17.1%, respectively. Due to tumor lysis syndrome (TLS; 8.2%), including two associated fatalities (one in another study cohort), additional risk-minimization measures were implemented. Overall response rate was 81.0%. After 32.8 months' median observation time, 2-year progression-free survival was 81.8%. Minimal residual disease was undetectable in 59.5% (94/158) and 27.8% (44/158) of patients for blood and bone marrow, respectively. Frontline G-B appears to have manageable toxicity with clinical activity in CLL. Careful TLS risk assessment, pretreatment and monitoring is required.
Association of Nodal Metastasis and Mortality With Vermilion vs Cutaneous Lip Location in Cutaneous Squamous Cell Carcinoma of the Lip
Authors: David M. Wang, Stefan Kraft, Pooyan Rohani, George F. Murphy, Robert J. Besaw, Pritesh S. Karia, Frederick C. Morgan, Chrysalyne D. Schmults
Journal: JAMA Dermatology (2018)

Although the lip is considered a high-risk location in cutaneous squamous cell carcinoma (cSCC), it has not been established whether this risk stems from vermilion or cutaneous locations or both.To compare differences in risks of recurrence, metastasis, and death from cSCCs on the vermilion vs cutaneous lip.Retrospective cohort study of 303 patients with 310 primary cSCCs of the lip (138 cutaneous, 172 vermilion) diagnosed between 2000 and 2015 at 2 academic tertiary care centers in Boston, Massachusetts.Development of local recurrence, nodal metastasis, distant metastasis, disease-specific death, and all-cause death.Of the 303 study participants with 310 SCCs of the lip, 153 (50.5%) were men, and 150 (49.5%) were women; median age at diagnosis, 68 years (range, 27-93 years). Outcomes were as follows for vermilion vs cutaneous locations: local recurrence, 6.4% (11 of 172) vs 2.9% (4 of 138); nodal metastasis, 7.6% (13 of 172) vs 1.5% (2 of 138); distant metastasis, 0.6% (1 of 172) vs 0.7% (1 of 138); disease-specific death, 3.5% (6 of 172) vs 2.9% (4 of 138); and all-cause death, 26.7% (46 of 172) vs 29.0% (40 of 138). The difference was statistically significant for nodal metastasis (P = .01). In multivariable analysis, nodal metastasis was associated with vermilion lip location (subhazard ratio, 5.0; 95% CI, 1.1-23.8) and invasion beyond fat (fascia or beyond for vermilion lip) (subhazard ratio, 4.4; 95% CI, 1.3-14.9).The risk of nodal metastasis is 5-fold greater for cSCCs on the vermilion lip compared with those on the cutaneous lip. Squamous cell carcinomas of the cutaneous lip have a nodal metastasis risk similar to cSCCs in general (1.5%). Thus, vermilion involvement appears responsible for the increased risk associated with cSCC of lip. Vermilion involvement may merit radiologic nodal staging and inclusion in future tumor staging, since it was independently associated with higher-risk cSCC of the lip region.
Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4/IL-13
Authors: Maha Zohra Ladjemi, Delphine Gras, Sébastien Dupasquier, Bruno Detry, Marylène Lecocq, Céline Garulli, Chantal Fregimilicka, Caroline Bouzin, Sophie Gohy, Pascal Chanez, Charles Pilette
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Asthma is associated with increased lung IgE production, but whether the secretory IgA system is affected in this disease remains unknown.We explored mucosal IgA transport in human asthma and its potential regulation by T-helper cell type 2 inflammation.Bronchial biopsies from asthma and control subjects were assayed for bronchial epithelial polymeric immunoglobulin receptor (pIgR) expression and correlated to T-helper cell type 2 biomarkers. Bronchial epithelium reconstituted in vitro from these subjects, on culture in air-liquid interface, was assayed for pIgR expression and regulation by IL-4/IL-13.Downregulation of pIgR protein was observed in the bronchial epithelium from patients with asthma (P = 0.0002 vs. control subjects). This epithelial defect was not observed ex vivo in the cultured epithelium from patients with asthma. Exogenous IL-13 and IL-4 could inhibit pIgR expression and IgA transcytosis. Mechanistic experiments showed that autocrine transforming growth factor-β mediates the IL-4/IL-13 effect on the pIgR, with a partial contribution of upregulated transforming growth factor-α/epidermal growth factor receptor.This study shows impaired bronchial epithelial pIgR expression in asthma, presumably affecting secretory IgA-mediated frontline defense as a result of type 2 immune activation of the transforming growth factor pathway.
Machine Learning Compared With Pathologist Assessment—Reply
Authors: Babak Ehteshami Bejnordi, Geert Litjens, Jeroen AWM van der Laak
Journal: JAMA (2018)

In Reply We agree that the 3 criteria pointed out by Dr van Smeden and colleagues are important when comparing algorithms and physicians in diagnostic studies. However, we do not agree that our study deviated from these criteria.
HIV Incidence, Prevalence, and Undiagnosed Infections in U.S. Men Who Have Sex With Men
Authors: Sonia Singh, Ruiguang Song, Anna Satcher Johnson, Eugene McCray, H. Irene Hall
Journal: Annals of Internal Medicine (2018)

HIV infection is a persistent health concern in the United States, and men who have sex with men (MSM) continue to be the most affected population.To estimate HIV incidence and prevalence and the percentage of undiagnosed HIV infections overall and among MSM.Cross-sectional analysis.National HIV Surveillance System.Persons aged 13 years or older with diagnosed HIV infection.Data on HIV diagnoses and the first CD4 test result after diagnosis were used to model HIV incidence and prevalence and the percentage of undiagnosed HIV infections from 2008 to 2015 on the basis of a well-characterized CD4 depletion model.Modeled HIV incidence decreased 14.8% overall, from 45 200 infections in 2008 to 38 500 in 2015, and among all transmission risk groups except MSM. The incidence of HIV increased 3.1% (95% CI, 1.6% to 4.5%) per year among Hispanic/Latino MSM (6300 infections in 2008, 7900 in 2015), decreased 2.7% (CI, -3.8% to -1.5%) per year among white MSM (8800 infections in 2008, 7100 in 2015), and remained stable among black MSM at about 10 000 infections. The incidence decreased by 3.0% (CI, -4.2% to -1.8%) per year among MSM aged 13 to 24 years and by 4.7% (CI, -6.2% to -3.1%) per year among those aged 35 to 44 years. Among MSM aged 25 to 34 years, HIV incidence increased 5.7% (CI, 4.4% to 7.0%) per year and among MSM aged 55 years and older, HIV increased 4.1% (CI, 0.8% to 7.4%). The percentage of undiagnosed HIV infections was higher among black, Hispanic/Latino, and younger MSM than white and older MSM, respectively.Assumptions of the CD4 depletion model and variability of CD4 values.Expansion of HIV screening to reduce undiagnosed infections and increased access to care and treatment to achieve viral suppression are critical to reduce HIV transmission. Access to prevention methods, such as condoms and preexposure prophylaxis, also is needed, particularly among MSM of color and young MSM.None.
A risk score combining quantitative hepatitis B surface antigen and core-related antigen levels to predict off-therapy relapse after cessation of nucleos(t)ide analogues in patients with chronic hepatitis B
Authors: Y.-C. Hsu, Y. Tanaka, M. Nguyen, C.-Y. Chang, C.-M. Tai, C.-H. Tseng, C.-C. Chen, M.-S. Wu, J.-T. Lin
Journal: Journal of Hepatology (2018)
An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder
Authors: Donna M. Werling, Harrison Brand, Joon-Yong An, Matthew R. Stone, Lingxue Zhu, Joseph T. Glessner, Ryan L. Collins, Shan Dong, Ryan M. Layer, Eirene Markenscoff-Papadimitriou, Andrew Farrell, Grace B. Schwartz, Harold Z. Wang, Benjamin B. Currall, Xuefang Zhao, Jeanselle Dea, Clif Duhn, Carolyn A. Erdman, Michael C. Gilson, Rachita Yadav, Robert E. Handsaker, Seva Kashin, Lambertus Klei, Jeffrey D. Mandell, Tomasz J. Nowakowski, Yuwen Liu, Sirisha Pochareddy, Louw Smith, Michael F. Walker, Matthew J. Waterman, Xin He, Arnold R. Kriegstein, John L. Rubenstein, Nenad Sestan, Steven A. McCarroll, Benjamin M. Neale, Hilary Coon, A. Jeremy Willsey, Joseph D. Buxbaum, Mark J. Daly, Matthew W. State, Aaron R. Quinlan, Gabor T. Marth, Kathryn Roeder, Bernie Devlin, Michael E. Talkowski, Stephan J. Sanders
Journal: Nature Genetics (2018)
Outcomes at 18 Months From a Community Health Worker and Peer Leader Diabetes Self-Management Program for Latino Adults
Authors: Michael S. Spencer, Edith C. Kieffer, Brandy Sinco, Gretchen Piatt, Gloria Palmisano, Jaclynn Hawkins, Alana Lebron, Nicolaus Espitia, Tricia Tang, Martha Funnell, Michele Heisler
Journal: Diabetes Care (2018)

This study evaluated the effectiveness of a community health worker (CHW) diabetes self-management education (DSME) program, followed by two different approaches to maintain improvements in HbA1c and other clinical and patient-centered outcomes over 18 months.The study randomized 222 Latino adults with type 2 diabetes and poor glycemic control from a federally qualified health center to 1) a CHW-led, 6-month DSME program or 2) enhanced usual care (EUC). After the 6-month program, participants randomized to the CHW-led DSME were further randomized to 1) 12 months of CHW-delivered monthly telephone outreach (CHW-only) or 2) 12 months of weekly group sessions delivered by peer leaders (PLs) with telephone outreach to those unable to attend (CHW+PL). The primary outcome was HbA1c. Secondary outcomes were blood pressure, lipid levels, diabetes distress, depressive symptoms, understanding of diabetes self-management, and diabetes social support. Assessments were conducted at baseline and at 6, 12, and 18 months.Participants in the CHW intervention at the 6-month follow-up had greater decreases in HbA1c (-0.45% [95% CI -0.87, -0.03]; P < 0.05) and in diabetes distress (-0.3 points [95% CI -0.6, -0.03]; P < 0.05) compared with EUC. CHW+PL participants maintained HbA1c improvements at 12 and 18 months, and CHW-only participants maintained improvements in diabetes distress at 12 and 18 months. CHW+PL participants also had significantly fewer depressive symptoms at 18 months compared with EUC (-2.2 points [95% CI -4.1, -0.3]; P < 0.05). Participants in CHW-led DSME had significant improvements in diabetes social support and in understanding of diabetes self-management at 6 months relative to EUC, but these intervention effects were not sustained at 18 months.This study demonstrates the effectiveness of a 6-month CHW intervention on key diabetes outcomes and of a volunteer PL program in sustaining key achieved gains. These are scalable models for health care centers in low-resource settings for achieving and maintaining improvements in key diabetes outcomes.
Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population
Authors: Matthias M. Mauschitz, Pieter W.M. Bonnemaijer, Kersten Diers, Franziska G. Rauscher, Tobias Elze, Christoph Engel, Markus Loeffler, Johanna Maria Colijn, M. Arfan Ikram, Johannes R. Vingerling, Katie M. Williams, Christopher J. Hammond, Catherine Creuzot-Garcher, Alain M. Bron, Rufino Silva, Sandrina Nunes, Cécile Delcourt, Audrey Cougnard-Grégoire, Frank G. Holz, Caroline C.W. Klaver, Monique M.B. Breteler, Robert P. Finger, Niyazi Acar, Eleftherios Anastosopoulos, Augusto Azuara-Blanco, Tos Berendschot, Tos Berendschot, Arthur Bergen, Geir Bertelsen, Christine Binquet, Alan Bird, Martin Bobak, Morten Bøgelund Larsen, Camiel Boon, Rupert Bourne, Lionel Brétillon, Rebecca Broe, Alain Bron, Gabrielle Buitendijk, Maria Luz Cachulo, Vittorio Capuano, Isabelle Carrière, Usha Chakravarthy, Michelle Chan, Petrus Chang, Johanna Colijn, Audrey Cougnard-Grégoire, Angela Cree, Catherine Creuzot-Garcher, Phillippa Cumberland, José Cunha-Vaz, Vincent Daien, Eiko De Jong, Gabor Deak, Cécile Delcourt, Marie-Noëlle Delyfer, Anneke den Hollander, Martha Dietzel, Maja Gran Erke, Pedro Faria, Claudia Farinha, Sascha Fauser, Robert Finger, Astrid Fletcher, Paul Foster, Panayiota Founti, Theo Gorgels, Jakob Grauslund, Franz Grus, Christopher Hammond, Hans-Werner Hense, Manuel Hermann, René Hoehn, Ruth Hogg, Frank Holz, Carel Hoyng, Nomdo Jansonius, Sarah Janssen, Eveline Kersten, Anthony Khawaja, Caroline Klaver, Jean-François Korobelnik, Julia Lamparter, Mélanie Le Goff, Yara Lechanteur, Terho Lehtimäki, Irene Leung, Andrew Lotery, Matthias Mauschitz, Magda Meester, Bénédicte Merle, Verena Meyer zu Westrup, Edoardo Midena, Stefania Miotto, Alireza Mirshahi, Sadek Mohan-Saïd, Michael Mueller, Alyson Muldrew, Joaquim Murta, Stefan Nickels, Sandrina Nunes, Christopher Owen, Tunde Peto, Norbert Pfeiffer, Stefano Piermarocchi, Elena Prokofyeva, Jugnoo Rahi, Olli Raitakari, Franziska Rauscher, Luisa Ribeiro, Marie-Bénédicte Rougier, Alicja Rudnicka, José Sahel, Aggeliki Salonikiou, Clarisa Sanchez, Steffen Schmitz-Valckenberg, Alexander Schuster, Cédric Schweitzer, Tatiana Segato, Jasmin Shehata, Rufino Silva, Giuliana Silvestri, Christian Simader, Eric Souied, Martynas Speckauskas, Henriet Springelkamp, Robyn Tapp, Fotis Topouzis, Elisa van Leeuwen, Virginie Verhoeven, Timo Verzijden, Therese Von Hanno, Peter Wiedemann, Katie Williams, Christian Wolfram, Jennifer Yip, Jennyfer Zerbib
Journal: Ophthalmology (2018)
Overcoming injustice: A roadmap to improve access to hepatitis C virus therapy for our medicaid patients
Authors: Leah D.B. Carter, Andrew Aronsohn
Journal: Hepatology (2017)

1Department of MedicineUniversity of ChicagoChicagoIL 2Center for Liver DiseaseSection of Gastroenterology, Hepatology and Nutrition, University of Chicago Medical CenterChicagoIL *ADDRESS CORRESPONDENCE AND REPRINT REQUESTS TO:Leah D.B. Carter, M.S.Department of Medicine, University of Chicago5841 S. Maryland Ave. MC 7082, RM A705 Chicago, IL 60637E‐mail: [email protected]Tel: + 1‐678‐850‐5010