tbuckley/cabot-search huggingface dataset:
Metabolically Healthy Obesity and High Carotid Intima-Media Thickness in Children and Adolescents: International Childhood Vascular Structure Evaluation Consortium
Authors: Min Zhao, Abel López-Bermejo, Carmelo A. Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Judit Bassols, Elisabetta L. Romeo, Thacira Dantas Almeida Ramos, George S. Stergiou, Lili Yang, Silvia Xargay-Torrent, Angela Amante, Tatianne Moura Estrela Gusmão, Evangelos Grammatikos, Yuanyuan Zhang, Anna Prats-Puig, Danielle Franklin de Carvalho, Liu Yang, Gemma Carreras-Badosa, Mônica de Oliveira Simões, Yaping Hou, Berta Mas-Pares, Wang Shui, Teng Guo, Mingming Wang, Hua Chen, Xiaohuan Lou, Qian Zhang, Yanqing Zhang, Pascal Bovet, Costan G. Magnussen, Bo Xi, Esther Lizarraga-Mollinedo, Ferran Diaz-Roldan, Ivelise Fhrideriad Alves Furtado da Costa, Camilla Ribeiro Lima de Farias, Renata Cardoso Oliveira, Camila Muniz Medeiros, Jéssica de Moraes Lira, Isidoros Psilopatis, Eirini Karagiaouri, Maria Glaraki, Emmanouel E. Grammatikos, Rafaela Ramos Dantas, Yggo Ramos de Farias Aires, Priscilla Yevelin Barros de Melo, Elayne Maria Cordeiro de Melo, Milena Cavalcanti Ramalho
Journal: Diabetes Care (2018)

It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy of CVD risk, in children and adolescents.Data were available for 3,497 children and adolescents aged 6-17 years from five population-based cross-sectional studies in Brazil, China, Greece, Italy, and Spain. Weight status categories (normal, overweight, and obese) were defined using BMI cutoffs from the International Obesity Task Force. Metabolic status (defined as "healthy" [no risk factors] or "unhealthy" [one or more risk factors]) was based on four CVD risk factors: elevated blood pressure, elevated triglyceride levels, reduced HDL cholesterol, and elevated fasting glucose. High cIMT was defined as cIMT ≥90th percentile for sex, age, and study population. Logistic regression model was used to examine the association of weight and metabolic status with high cIMT, with adjustment for sex, age, race/ethnicity, and study center.In comparison with metabolically healthy normal weight, odds ratios (ORs) for high cIMT were 2.29 (95% CI 1.58-3.32) for metabolically healthy overweight and 3.91 (2.46-6.21) for MHO. ORs for high cIMT were 1.44 (1.03-2.02) for unhealthy normal weight, 3.49 (2.51-4.85) for unhealthy overweight, and 6.96 (5.05-9.61) for unhealthy obesity.Among children and adolescents, cIMT was higher for both MHO and metabolically healthy overweight compared with metabolically healthy normal weight. Our findings reinforce the need for weight control in children and adolescents irrespective of their metabolic status.
AB1148 Biological treatment of non ischaemic optic neuritisassociated to immune-mediated inflammatory diseases. multicenter study
Authors: L.C. Domínguez Casas, V. Calvo-Río, O. Maríz-Alonso, A. Blanco, J. Narvaez, S. Castañeda, E. Vicente, S. Romero Yuste, R. Demetrio-Pablo, N. Vegas-Revenga, M. Gonzalez-Gay, R. Blanco
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Non ischaemic optic neuritis (NION) is a severe inflammation of the optic nerve that may lead to blindness. It can be primary or associated to immune-mediated inflammatory diseases (IMIDs). The treatment of the NION is based on systemic corticosteroids and conventional immunosuppressive drugs. <h3>Objectives</h3> To assess the efficacy of the biological treatment in refractory NION to conventional treatment. <h3>Methods</h3> Multicenter study of 8 patients diagnosed with NION refractory to systemic corticosteroids and at least one conventional immunosuppressive drug. The main outcomes were visual acuity (VA) and OCT of the optic nerve and the ganglionar cells. Comparisons were made between baseline and the 1st week, 1st and 6th month and 1st year. (STATISTICA, StatSoft Inc. Tulsa, Oklahoma, USA). <h3>Results</h3> We studied 8 patients (12 affected eyes) (4♀/4♂); mean age of 34.37±13.30 years. The underlying diseases were SLE (n=1), neuromyelitis optica (n=1), neuroretinitis (n=1), relapsing polychondritis (n=1), idiopathic (n=2) and Behçet's disease (n=2). Before biological treatment and besides oral corticosteroids patients had received intravenous (IV) methylprednisolone boluses (n=6), cyclosporine A (CyA) (n=1), ciclophosphamide (n=2), micophenolate (n=2), hydroxycloroquine (n=1), methotrexate (MTX) (n=4) and azathioprine (AZA) (n=2). Biological treatment was based on rituximab (n=2) (2 IV. doses of 1 g/very 2 weeks and every 6 months), adalimumab (n=2) 40 mg/week, tocilizumab (n=2) 8 mg/kg/2–4 weeks and infliximab (n=2) 5 mg/kg at 0, 2 and 6 week and then every 8 weeks. The characteristics of the 8 patients are shown in the <b>TABLE</b> After biological treatment we observed an improvement in the ocular parameters: VA [0.60±0.33 to 0.76±0.41, p: 0.04], OCT of the optic nerve [130.63±60.54 to 102.60±8.17, p: 0.1] and OCT of the ganglionar cells [404.60±184.73 to 243±18.38, p: 0.17] at one year. After a mean follow-up of 27±14.47 months there were no severe adverse effects. <h3>Conclusions</h3> This study shows that treatment with biologic drugs, including ant-TNF drugs, in NION associated to IMIDs, refractory to conventional treatment, seems to be effective. These results must be confirmed in prospective and randomised trials. <h3>Disclosure of Interest</h3> None declared
Targeted Inhibition of CD47-Sirp Alpha Requires Fc-Fc Gamma Receptor Interactions to Maximize Phagocytosis in T-Cell Lymphomas
Authors: Salvia Jain, Alexandria Van Scoyk, Elizabeth A Morgan, Andrew Matthews, Kristen E. Stevenson, Gail Newton, Anu K Autio, Marisa O. Peluso, Rachel W O'Connor, Alison M. Paterson, Pamela M. Holland, Francis W Luscinskas, David M Weinstock
Journal: Blood (2018)
SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations
Authors: Rui Costa, Daniel Todt, Francisco Zapatero-Belinchón, Christian Schenk, Olympia E. Anastasiou, Andreas Walker, Barbara Hertel, Lejla Timmer, Denisa Bojkova, Maren Ruckert, Christoph Sarrazin, Jörg Timm, Volker Lohmann, Michael P. Manns, Eike Steinmann, Thomas von Hahn, Sandra Ciesek
Journal: Journal of Hepatology (2018)
Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer
Authors: May Tun Saung, Stephen Muth, Ding Ding, Dwayne L. Thomas, Alex B. Blair, Takahiro Tsujikawa, Lisa Coussens, Elizabeth M. Jaffee, Lei Zheng
Journal: Journal for ImmunoTherapy of Cancer (2018)

<h3>Background</h3> The pancreatic cancer vaccine, GVAX, induces novel lymphoid aggregates in the otherwise immune quiescent pancreatic ductal adenocarcinoma (PDAC). GVAX also upregulates the PD-1/PD-L1 pathway, and a pre-clinical model demonstrated the anti-tumor effects of combination GVAX and anti-PD-1 antibody therapy (GVAX/αPD-1). Resistance to GVAX was associated with an immune-suppressive myeloid cell infiltration, which may limit further therapeutic gains of GVAX/αPD-1 therapy. The expression of CSF-1R, a receptor important for myeloid cell migration, differentiation and survival, and the effect of its therapeutic blockade in the context of GVAX in PDAC has not been investigated. <h3>Methods</h3> Lymphoid aggregates appreciated in 24 surgically resected PDAC from patients who received one dose of neoadjuvant GVAX were analyzed with multiplex immunohistochemistry. Flow cytometry analysis of tumor infiltrating T-cells in a murine model of PDAC was performed to investigate the therapeutic effects and mechanism of anti-CSF-1R/anti-PD-1/GVAX combination immunotherapy. <h3>Results</h3> High CSF-1R expression in resected PDAC from patients who received neoadjuvant GVAX was associated with a higher myeloid to lymphoid cell ratio (<i>p</i> &lt; 0.05), which has been associated with poorer survival. This higher CSF-1R expression was associated with a higher intra-tumoral infiltration of immature dendritic cells (<i>p</i> &lt; 0.05), but not mature dendritic cells (<i>p</i> = 0.132). In the pre-clinical murine model, administering anti-CSF-1R antibody prior to and after GVAX/αPD-1 ("pre/post-αCSF-1R + αPD-1 + GVAX") enhanced the survival rate compared to GVAX/αPD-1 dual therapy (<i>p</i> = 0.005), but administering anti-CSF-1R only before GVAX/αPD-1 did not (<i>p</i> = 0.41). The "pre/post-αCSF-1R + αPD-1 + GVAX" group also had higher intra-tumoral infiltration of PD-1 + CD8+ and PD-1 + CD4+ T-cells compared to αPD-1/GVAX (<i>p</i> &lt; 0.001). Furthermore, this regimen increased the intra-tumoral infiltration of PD-1 + CD137 + CD8+, PD-1 + CD137 + CD4+ and PD-1 + OX40 + CD4+ T-cells (<i>p</i> &lt; 0.001). These PD-1 + CD137 + CD8+ T-cells expressed high levels of interferon-γ (median 80–90%) in response to stimulation with CD3/CD28 activation beads, and this expression was higher than that of PD-1 + CD137-CD8+ T-cells (<i>p</i> &lt; 0.001). <h3>Conclusions</h3> The conversion of exhausted PD-1+ T-cells to CD137+ activated effector T-cells may contribute to the anti-tumor effects of the anti-CSF-1R/anti-PD-1/GVAX combination therapy. Anti-CSF-1R antibody with anti-PD-1 antibody and GVAX have the potential be an effective therapeutic strategy for treatment of PDAC.
AB0224 Cervical proprioceptive impairement in patients with rheumatoid arthritis
Authors: F. Ulutatar, M.T. Duruoz
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis (RA) is autoimmune disease that usually involves cervical part of the vertebral column which can cause cervical proprioceptive deficit. <h3>Objectives</h3> Assessment of cervical proprioception and its relation with radiographic, clinical and functional characteristics of patients with RA <h3>Methods</h3> Rheumatoid arthritis patients who diagnosed according to <sup>ACR 2010</sup> criteria and control group with healthy volunteers were recruited in the study. Demographic and clinical parameters were noted. Cervical proprioception was evaluated by Cervical Joint Position Error Test (CJPET). Functional assessment scales that used in this study were Multidimensional Assessment of Fatigue (MAF), Beck Depression Inventory, Health Assessment Questionairre (HAQ), Euroqol 5D (EQ-5D) and Berg Balance Scale. Cervical subluxations were noted according to cervical radiographic image. The differerence in mean scores of CJPET between RA patients and healthy volunteers were analysed with Mann-Whitney U test. Spearman correlation coefficient (rho) was used for correlations between functional parameters. Regression analysis was used for grading factors which had relations with cervical proprioception. <h3>Results</h3> One hundred six rheumatoid arthritis patients and one hundred six healthy volunteers were enrolled in this study. Mean age of patients and healthy volunteers were 51,0 (Sd:11,1) and 48,9 (Sd:9,2), respectively. Scores of CJPET are statistically significantly higher in rheumatoid arthritis group than healthy volunteers (p=0,001) (table 1). CJPET scores are negatively correlated with Berg Balance Scale results in all directions (rho= −0,421,–0,473,−0,448,–0,515). Scores of CJPET in patients with atlantoaxial subluxations (AAS) were statistically significantly higher than those without AAS (p=0,002–0,045). Regression analysis results showed that AAS is related with worser cervical proprioception on right and left rotations. There were no correlation between CJPET scores and functional parameters. Weak corelation were found in scores of CJPET with age and educational status. <h3>Conclusions</h3> Cervical proprioception is impaired in rheumatoid arthritis patients. This impairement is increased with the existance of atlantoaxial subluxations and balance problems. <h3>Disclosure of Interest</h3> None declared
Sustained and regulated gene expression by Tet-inducible “all-in-one” retroviral vectors containing the HNRPA2B1-CBX3 UCOE®
Authors: Katharina Cullmann, Kaj E.C. Blokland, Attila Sebe, Franziska Schenk, Zoltán Ivics, Niels Heinz, Ute Modlich
Journal: Biomaterials (2018)
Abstract 18785: Should We Recommend Triple Therapy for Patients Undergoing Stent Implantation With a High Score HAS-BLED?
Authors: Antonia Sambola
Journal: Circulation (2014)

Introduction: Current clinical guidelines recommend the use of HAS-BLED score to assess the risk of bleeding in patients requiring oral anticoagulation (OAC) undergoing percutaneous coronary intervention with stenting (PCI-S). Hypothesis: The use of OAC in patients requiring OAC with a high score HAS-BLED would be not safe. Objective: To evaluate the safety of OAC in patients with indication and a high risk of bleeding (HAS-BLED score ≥ 3) who undergoing PCI-s. Methods: A prospective multicenter study was conducted from 2007 to 2012 to identify patients requiring long-term OAC undergoing PCI-S. All adverse outcomes were analyzed at 1-year follow-up. Results: We identified 828 patients requiring OAC (77.3% male, 72.0±9.3 years) undergoing PCI-S. Five-hundred thirteen (62%) had a HAS-BLED ≥ 3. Of these, 329 (64.8%) received OAC. These patients had a mortality rate (10.1% vs. 10.3%) and major adverse cardiac events rate (MACE) (19.6% vs. 18.8%, p=0:46) similar to those who did not receive OAC. However, bleeding events rate was significantly higher (15.1% vs. 23.7%, p=0.01) with an excess of major bleeding (3.4% vs. 9.2%, p=0.01) in patients treated on OAC. In a multivariate analysis, in patients with a HAS-BLED ≥ 3: age (p=0.02) and renal failure (p &lt;0.001) were predictors of mortality, but OAC was not associated with mortality. The only predictor of bleeding events was the use of OAC (p=0.01), while renal failure and use of drug eluting stents were not. Conclusions: A high percentage of patients undergoing PCI-S have a high bleeding risk (HAS-BLED ≥ 3). In these patients, the use of OAC does not seem to improve prognosis, but increases the incidence of major bleeding.
Deciphering cancer fibroblasts
Authors: Giulia Biffi, David A. Tuveson
Journal: The Journal of Experimental Medicine (2018)

In this issue of JEM, Raz et al. (https://doi.org/10.1084/jem.20180818) identify a subset of bone marrow–derived cells that uniquely promotes breast cancer angiogenesis and tumor growth. The existence of functional heterogeneity among stromal populations motivates further fundamental and therapeutic inquiries.
Advances in optimizing the prescription of antibiotics in outpatient settings
Authors: Laura M King, Katherine E Fleming-Dutra, Lauri A Hicks
Journal: BMJ (2018)

Abstract The inappropriate use of antibiotics can increase the likelihood of antibiotic resistance and adverse events. In the United States, nearly a third of antibiotic prescriptions in outpatient settings are unnecessary, and the selection of antibiotics and duration of treatment are also often inappropriate. Evidence shows that antibiotic prescribing is influenced by psychosocial factors, including lack of accountability, perceived patient expectations, clinician workload, and habit. A varied and growing body of evidence, including meta-analyses and randomized controlled trials, has evaluated interventions to optimize the use of antibiotics. Interventions informed by behavioral science—such as communication skills training, audit and feedback with peer comparison, public commitment posters, and accountable justification—have been associated with improved antibiotic prescribing. In addition, delayed prescribing, active monitoring, and the use of diagnostics are guideline recommended practices that improve antibiotic use for some conditions. In 2016, the Centers for Disease Control and Prevention released the Core Elements of Outpatient Antibiotic Stewardship , which provides a framework for implementing these interventions in outpatient settings. This review summarizes the varied evidence on drivers of inappropriate prescription of antibiotics in outpatient settings and potential interventions to improve their use in such settings.
IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies
Authors: Elisa Bergaggio, Chiara Riganti, Giulia Garaffo, Nicoletta Vitale, Elisabetta Mereu, Cecilia Bandini, Elisa Pellegrino, Verdiana Pullano, Paola Omedè, Katia Todoerti, Luciano Cascione, Valentina Audrito, Anna Riccio, Antonio Rossi, Francesco Bertoni, Silvia Deaglio, Antonino Neri, Antonio Palumbo, Roberto Piva
Journal: Blood (2018)
Should tobacco interventions be different in men and women?
Authors: J. Ignacio de Granda-Orive, J.F. Pascual-Lledó, S. Asensio-Sánchez, S. Solano-Reina, M. García-Rueda, M.Á. Martínez-Muñiz, L. Lázaro-Asegurado, D. Bujulbasichg, R. Pendino, S. Luhning, I. Cienfuegos-Agustín, C.A. Jiménez-Ruiz
Journal: Pulmonology (2018)
Risk of radiation-associated intracranial malignancy after stereotactic radiosurgery: a retrospective, multicentre, cohort study
Authors: Amparo Wolf, Kyla Naylor, Moses Tam, Akram Habibi, Josef Novotny, Roman Liščák, Nuria Martinez-Moreno, Roberto Martinez-Alvarez, Nathaniel Sisterson, John G Golfinos, Joshua Silverman, Hideyuki Kano, Jason Sheehan, L Dade Lunsford, Douglas Kondziolka
Journal: The Lancet Oncology (2018)
Abstract 10989: A Meta-Analysis of Transcatheter Closure of Patent Foramen Ovale versus Medical Therapy for Prevention of Recurrent Thromboembolic Events in Patients With Cryptogenic Cerebrovascular Events
Authors: Andres M Pineda, Francisco O Nascimento, Solomon Yang, Ajay J Kirtane, Robert J Sommer, Nirat Beohar
Journal: Circulation (2013)

Introduction: Although previous observational studies have suggested that transcatheter closure of patent foramen ovale (PFO) decreases the incidence of recurrent neurological events after cryptoge...
Abstract 12231: Impact of Changes in the International Resuscitation Guidelines for Out-of-Hospital Cardiac Arrest Stratified by Initial Cardiac Arrest Rhythm
Authors: Ken Nagao, Hiroshi Nonogi, Naohiro Yonemoto, David F Gaieski, Noritoshi Ito, Shinichi Shirai, Sigemasa Tani, Tsukasa Yagi, Eizo Tachibana, Takeshi Kimura, Keijiro Saku, Hiroaki Simokawa
Journal: Circulation (2017)

Background: The AHA and ILCOR published the Guidelines 2000 for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care (ECC). Since 2000, the ILCOR has reported the International Con...
Prognostic and therapeutic significance of phosphorylated STAT3 and protein tyrosine phosphatase-6 in peripheral-T cell lymphoma
Authors: Jing Jing Han, Megan O’byrne, Mary J. Stenson, Matthew J. Maurer, Linda E. Wellik, Andrew L. Feldman, Ellen D. McPhail, Thomas E. Witzig, Mamta Gupta
Journal: Blood Cancer Journal (2018)

Peripheral T cell lymphomas (PTCL) is a heterogenous group of non-Hodgkin lymphoma and many patients remain refractory to the frontline therapy. Identifying new prognostic markers and treatment is an unmet need in PTCL. We analyzed phospho-STAT3 (pSTAT3) expression in a cohort of 169 PTCL tumors and show overall 38% positivity with varied distribution among PTCL subtypes with 27% (16/59) in PTCL-NOS; 29% (11/38) in AITL, 57% (13/28) in ALK-negative ALCL, and 93% in ALK-pos ALCL (14/15), respectively. Correlative analysis indicated an adverse correlation between pSTAT3 and overall survival (OS). PTPN6, a tyrosine phosphatase and potential negative regulator of STAT3 activity, was suppressed in 62% of PTCL-NOS, 42% of AITL, 60% ALK-neg ALCL, and 86% of ALK-pos ALCL. Loss of PTPN6 combined with pSTAT3 positivity predicted an infwere considered significantferior OS in PTCL cases. In vitro treatment of TCL lines with azacytidine (aza), a DNA methyltransferase inhibitor (DNMTi), restored PTPN6 expression and decreased pSTAT3. Combining DNMTi with JAK3 inhibitor resulted in synergistic antitumor activity in SUDHL1 cell line. Overall, our results suggest that PTPN6 and activated STAT3 can be developed as prognostic markers, and the combination of DNMTi and JAK3 inhibitors as a novel treatment for patients with PTCL subtypes.
Unilesional mycosis fungoides is associated with increased expression of micro <scp>RNA</scp> ‐17~92 and T helper 1 skewing
Authors: L. Moyal, B. Gorovitz‐Haris, S. Yehezkel, J. Jacob‐Hirsch, V. Bershtein, A. Barzilai, C. Rotem, S. Sherman, I. Amitay‐Laish, M. Feinmesser, E. Hodak
Journal: British Journal of Dermatology (2018)

The molecular basis of unilesional mycosis fungoides (MF), characterized by a solitary lesion that is clinicopathologically indistinguishable from multifocal patch or plaque MF (early MF), is unknown. To investigate the microRNA profile in unilesional MF distinguishing it from early MF. Biopsy samples of unilesional MF and early MF were evaluated with the Affymetrix microRNA array, with further comparison with inflammatory dermatosis, using quantitative polymerase chain reaction. NanoString technology was applied to analyse the gene expression of T helper (Th)1 immune markers, and immunohistochemistry was used to evaluate CXCR3 and GATA‐binding protein 3 (GATA3) markers for Th1 and Th2 cells, respectively. Unilesional MF had a significantly higher level of expression of all members of the microRNA miR‐17~92 cluster than early MF. Specifically, unilesional MF had a higher miR‐17 level than early MF and inflammatory dermatoses. There was downregulation of the expression of phosphatase and tensin homolog (PTEN) and CREB1, known targets of miR‐17~92 members; higher gene expression of interleukin‐2 and interferon‐γ; and a statistically lower average percentage of GATA3+ dermal cells (6·7% vs. 42·3%), were detected in unilesional MF compared with early MF. High immunoreactivity of CXCR3 was noted in both unilesional and early MF. Unilesional MF exhibits a microRNA profile distinct from that of conventional early MF, with a higher level of miR‐17~92 members along with Th1 skewing. These findings suggest a robust reactive T‐cell immune response in unilesional MF and might account for the localized nature of this disease.
JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells
Authors: Hamza Celik, Won Kyun Koh, Ashley C. Kramer, Elizabeth L. Ostrander, Cates Mallaney, Daniel A.C. Fisher, Jingyu Xiang, William C. Wilson, Andrew Martens, Alok Kothari, Gregory Fishberger, Eric Tycksen, Darja Karpova, Eric J. Duncavage, Youngsook Lee, Stephen T. Oh, Grant A. Challen
Journal: Cancer Cell (2018)
Сучасні підходи до терапії синдрому подразненого кишечника через призму осі «кишечник — мозок»
Authors: Ye.S. Sirchak
Journal: GASTROENTEROLOGY (2018)

Синдром подразненого кишечника (СПК) — один із найбільш частих функціональних розладів шлунково-кишкового тракту. Значну роль у його виникненні відіграє взаємодія факторів зовнішнього середовища й індивідуальних особливостей пацієнта. Серед останніх виділяють, зокрема, порушення моторики кишечника, вісцеральну гіперчутливість, знижену активність імунної системи, порушення бар’єрної функції кишечника, мікрозапалення (low-grade) й зміни кишкової мікробіоти внаслідок порушення функціо­нування сигнальної системи між кишечником і головним мозком. У статті наведено сучасні відомості про вплив мікробіоти кишечника на функціонування мозку через вісь, що включає центральну нервову систему, блукаючий нерв, обмін триптофану, нейроендокринні й нейроімунні системи, гіпоталамо-гіпофізарно-надниркову, вегетативну нервову й ентеральну нервову системи. Висвітлено доцільність та ефективність використання засобу Альфлорекс (штам B.іnfantis 35624) для сприяння зменшенню всіх клінічних симптомів синдрому подразненого кишечника, що пов’язано з його імуномодулюючим, протизапальним ефектами, а також впливом на обмін триптофану й серотоніну, який, у свою чергу, модулює моторну діяльність і віс­церальну гіперчутливість через нормалізацію передачі сигналів між кишечником і мозком.
Abstract 15888: Comparative Effectiveness of Coronary CT Angiography versus Stress Echocardiography in Real-World Emergency Department Patients With Low-Risk Chest Pain
Authors: Andrew J Foy, Sanket S Dhruva, John M Mandrola, Rita F Redberg
Journal: Circulation (2017)

Introduction: There are limited data comparing the real-world effectiveness of coronary CT angiography (CCTA) versus stress echocardiography (SE) on clinical outcomes in emergency department (ED) p...