tbuckley/cabot-search huggingface dataset:
A new natural compound identified through a metabolomic approach has cytotoxic activity against human colorectal cancer cell lines with acquired resistance to cetuximab
Authors: V. De Falco, E.F. Giunta, V. Belli, N. Matrone, S. Napolitano, E. Martinelli, P. Vitale, N. Zanaletti, M. Terminiello, P.P. Vitiello, F. Ciardiello, T. Troiani
Journal: Annals of Oncology (2018)
Real-world effectiveness of ribociclib + aromatase inhibitor, or endocrine monotherapy, or chemotherapy as first-line treatment in postmenopausal women with HR-positive, HER2-negative locally advanced or metastatic breast cancer: The RIBANNA study
Authors: P.A. Fasching, T. Decker, G. Guderian, J. Heim, C. Jackisch, H.-J. Lueck, D. Lüftner, F. Marmé, T. Reimer, A. Woeckel
Journal: Annals of Oncology (2018)
P3.11-25 Analysis Indicates Low Incremental Cost-Effectiveness Ratio for Implementation of Lung Cancer Screening in Italy
Authors: G. Veronesi, S. Ghislandi, E. Vanni, E. Dieci, L. Toschi, L. Velutti, M. Solinas, P. Novellis, M. Alloisio, E. Riboli, N. Navone
Journal: Journal of Thoracic Oncology (2018)
Abstract 19946: Airports: Out-of-hospital Chain of Survival Laboratory?
Authors: Joséphine Escutnaire, Nicolas Segal, Marion Menay, Philippe Bargain, Patrice Mannhart, Jean-Luc Caron, Laurent Villain-Coquet, Herve Hubert
Journal: Circulation (2015)

Introduction: Airports are experimentation locations in which automatic external defibrillators (AED) implementation efficacy (and efficiency) has been widely tested. Hypothesis: With a large number of passengers and a fine meshing in terms of AED availability, the aim of this study is to understand the airport cardiac arrests (ACA) in terms of care and to study their survival in such a particular location. Methods: Prospective descriptive and multicentre study based on the French national cardiac arrest registry (RéAC) data gathered between the 01/07/2011 and the 01/11/2014. Results: We analysed 78 ACA among 35667 cardiac arrests. We recorded 83.3% men. The population’s median age was 63 [52-70]. A medical aetiology was recorded in 93.6% cases and 30% had history of cardiovascular diseases. Professional first aid providers’ (generally firemen) median response time was 5 [1-10] min and mobile medical teams’ (MMT) 20 [12-30] min. Three quarter of patients were immediately cared by witnesses of which 53.8% benefited of an AED connexion ; 23.1% of them received a shock. A cardiopulmonary resuscitation (CPR) was attempted by firemen in 84.6% cases. At MMT arrival, 13.3% had a shockable rhythm and 26.7% had already sustained a return of spontaneous circulation. MMT attempted CPR in 87.2% cases and 37.2% sustained a return of spontaneous circulation (ROSC). At hospital admission, 34.6% were alive. At Day 30, 14.1% survived of which 81.9% had a good neurological outcome (CPC1-2). Among them 27.3% had a implantation of automatic defibrillator. Cardiac aetiology was proved in 28% cases and almost half of patients returned directly at home after their hospitalization. Conclusions: ACA victims are often cared very promptly by bystanders, professional first aid providers and medical teams. They also more often benefit of AED connexion and shock than cardiac arrest victims in the general population. Airports are indeed a location in which all the steps of the chain of survival are thoroughly and effectively implemented. As all these steps are patients’ survival key factors, this results in better outcome.
Preliminary results of a ph2a study to evaluate the clinical efficacy and safety of erdafitinib in Asian patients with biomarker-selected advanced cholangiocarcinoma (CCA)
Authors: Y.-Y. Chen, J.O. Park, W.-C. Su, D.-Y. Oh, K.-P. Kim, Y.-H. Feng, L. Shen, H. Liao, J. Nie, M. Qing, J. Li, P. De Porre
Journal: Annals of Oncology (2018)
A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila
Authors: Alessandro Scopelliti, Christin Bauer, Yachuan Yu, Tong Zhang, Björn Kruspig, Daniel J. Murphy, Marcos Vidal, Oliver D.K. Maddocks, Julia B. Cordero
Journal: Cell Metabolism (2018)

The control of systemic metabolic homeostasis involves complex inter-tissue programs that coordinate energy production, storage, and consumption, to maintain organismal fitness upon environmental challenges. The mechanisms driving such programs are largely unknown. Here, we show that enteroendocrine cells in the adult Drosophila intestine respond to nutrients by secreting the hormone Bursicon α, which signals via its neuronal receptor DLgr2. Bursicon α/DLgr2 regulate energy metabolism through a neuronal relay leading to the restriction of glucagon-like, adipokinetic hormone (AKH) production by the corpora cardiaca and subsequent modulation of AKH receptor signaling within the adipose tissue. Impaired Bursicon α/DLgr2 signaling leads to exacerbated glucose oxidation and depletion of energy stores with consequent reduced organismal resistance to nutrient restrictive conditions. Altogether, our work reveals an intestinal/neuronal/adipose tissue inter-organ communication network that is essential to restrict the use of energy and that may provide insights into the physiopathology of endocrine-regulated metabolic homeostasis.
Neoadjuvant trial of nab-paclitaxel and atezolizumab (Atezo), a PD-L1 inhibitor, in patients (pts) with chemo-insensitive triple negative breast cancer (TNBC)
Authors: J.K. Litton, S.L. Moulder, K.R. Hess, S. Damodaran, G.M. Rauch, R. Candelaria, B.E. Adrada, F. Symmans, R.K. Murthy, T. Helgason, A. Clayborn, S. Prabhakaran, V. Valero, A.M. Thompson, E.A. Mittendorf
Journal: Annals of Oncology (2018)
Abstract 17705: VSMC-specific Genetic Deletion of NoxA1, a Regulatory Subunit of Nox1 NADPH Oxidase, Attenuates Vascular Inflammation and Atherosclerosis in ApoE-/- Mice
Authors: Arihiro Sumida, Aleksandr Vendrov, Jinling Yuan, Qi-An Sun, Nageswara Madamanchi, Marschall Runge
Journal: Circulation (2014)

Oxidative stress-induced activation of vascular smooth muscle cells (VSMC) is a key step in the initiation and progression of inflammation and atherogenesis and a potential target for therapy. We p...
Inappropriate Use of Medical Conditions as Metaphors
Authors: Dimitri A. Christakis
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Minding Our Metaphors—Reply
Authors: Peter Louis Loper
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
A combination of plasma phospholipid fatty acids and incidence of type 2 diabetes
Authors: F Imamura, S J Sharp, A Koulman, M B Schulze, J Kröger, J L Griffin, J M Huerta, M Guevara, I Sluijs, A Agudo, E Ardanaz, B Balkau, H Boeing, V Chajes, C C Dahm, C Dow, G Fagherazzi, Feskens Ejm., P W Franks, D Gavrila, M Gunter, R Kaaks, T J Key, Khaw K-T., T Kühn, O Melander, E Molina-Portillo, P M Nilsson, A Olsen, K Overvad, D Palli, S Panico, O Rolandsson, S Sabina, C Sacerdote, N Slimani, A M Spijkerman, A Tjønneland, R Tumino, Y T van der Schouw, C Langenberg, E Riboli, N G Forouhi, N J Wareham
Journal: PLoS Medicine (2017)
Abstract 18138: Heart Failure Transitions Program
Authors: Monique Colbert, Burhan Mohamedali, Kena Lanham, Erica Feddeler, Fatimata Diabate, Madeleine Rooney, Eliazbeth Tampe, Lizabetth Gomez, Barbara Hinch
Journal: Circulation (2017)

Introduction: A large Midwest Academic Medical Center is not at their predicted rate of readmission for heart failure (HF). We describe the development of a heart failure transition program (HFTP) ...
Abstract 13763: Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury
Authors: Hironori Hara, Norifumi Takeda, Tatsuo Saito, Takayuki Fujiwara, Sonoko Maemura, Yutaka Hata, Masanobu Uchiyama, Issei Komuro
Journal: Circulation (2017)

Introduction: It has become increasing evident that new cardiomyocytes (CMs) in adult mammalians are generated at a low rate. However, this limited regenerative capacity is unable to restore cardia...
ODM-207: A novel BET bromodomain inhibitor with antitumor activity in nonclinical models of ER+ breast cancer
Authors: A. Moilanen, J. Lindqvist, M. Björkman, R. Riikonen, D. Nicorici, E. Mattila, C. Abbineni, M. Jaleel, J. Eriksson, P. Kallio
Journal: Annals of Oncology (2018)
Therapeutic potential of carbonyl-scavenging carnosine derivative in metabolic disorders
Authors: Jacob M. Haus, John P. Thyfault
Journal: Journal of Clinical Investigation (2018)

Obesity and overnutrition increase levels of reactive sugar- and lipid-derived aldehydes called reactive carbonyl species (RCS). Increased tissue and circulating RCS levels have been tied to insulin resistance and inflammation, but previous pharmacological approaches to target RCS have had equivocal outcomes. In this issue of the JCI, Anderson et al. present evidence for the development and implementation of carnisonol, a compound that is biologically stable in vivo and shows impressive effects on improving metabolism and inflammation in rodent models of diet-induced obesity and metabolic dysfunction.
The neuropsychopharmacology of cannabis: A review of human imaging studies
Authors: Michael A.P. Bloomfield, Chandni Hindocha, Sebastian F. Green, Matthew B. Wall, Rachel Lees, Katherine Petrilli, Harry Costello, M. Olabisi Ogunbiyi, Matthijs G. Bossong, Tom P. Freeman
Journal: Pharmacology & Therapeutics (2018)

The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in cannabis is Δ9-tetrahydrocannabinol (THC), a partial agonist at the endocannabinoid CB1 receptor. Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems. These include effects on executive, emotional, reward and memory processing via direct interactions with the endocannabinoid system and indirect effects on the glutamatergic, GABAergic and dopaminergic systems. Cannabidiol, a non-intoxicating cannabinoid found in some forms of cannabis, may offset some of these acute effects. Heavy repeated cannabis use, particularly during adolescence, has been associated with adverse effects on these systems, which increase the risk of mental illnesses including addiction and psychosis. Here, we provide a comprehensive state of the art review on the acute and chronic neuropsychopharmacology of cannabis by synthesizing the available neuroimaging research in humans. We describe the effects of drug exposure during development, implications for understanding psychosis and cannabis use disorder, and methodological considerations. Greater understanding of the precise mechanisms underlying the effects of cannabis may also give rise to new treatment targets.
18F-fluorodeoxyglucose positron-emission tomography/CT and lung involvement in systemic sclerosis
Authors: Silvia Bellando-Randone, Luca Tartarelli, Edorardo Cavigli, Lorenzo Tofani, Cosimo Bruni, Gemma Lepri, Jelena Blagojevic, Alberto Moggi-Pignone, Carina Mihai, Jerome Avouac, Alessandro Passeri, Maria Teresa De Cristofaro, Oliver Distler, Yannick Allanore, Serena Guiducci, Marco Matucci-Cerinic
Journal: Annals of the Rheumatic Diseases (2018)

Figure 1 Differences in 18F-FDG uptake between 'positive' segments of Warrick score >0 SSc patients, 'negative' segments of Warrick score >0 SSc patients and 'negative' segments of Warrick score=0 SSc patients versus attended normalised control value (=1).18F-FDG, 18-F fluoro-deoxy-dglucose; SSc, systemic sclerosis; SUV, standardised uptake value.
Structural evidence for a new elaborate 3D-organization of the cardiomyocyte lateral membrane in adult mammalian cardiac tissues
Authors: Céline Guilbeau-Frugier, Marie Cauquil, Clément Karsenty, Olivier Lairez, Camille Dambrin, Bruno Payré, Hervé Cassard, Claudie Josse, Marie-Hélène Seguelas, Sophie Allart, Maxime Branchereau, Christophe Heymes, Franck Mandel, Marie-Bernadette Delisle, Atul Pathak, Etienne Dague, Jean-Michel Sénard, Céline Galés
Journal: Cardiovascular Research (2018)

This study explored the lateral crest structures of adult cardiomyocytes (CMs) within healthy and diseased cardiac tissue.Using high-resolution electron and atomic force microscopy, we performed an exhaustive quantitative analysis of the three-dimensional (3D) structure of the CM lateral surface in different cardiac compartments from various mammalian species (mouse, rat, cow, and human) and determined the technical pitfalls that limit its observation. Although crests were observed in nearly all CMs from all heart compartments in all species, we showed that their heights, dictated by the subsarcolemmal mitochondria number, substantially differ between compartments from one species to another and tightly correlate with the sarcomere length. Differences in crest heights also exist between species; for example, the similar cardiac compartments in cows and humans exhibit higher crests than rodents. Unexpectedly, we found that lateral surface crests establish tight junctional contacts with crests from neighbouring CMs. Consistently, super-resolution SIM or STED-based immunofluorescence imaging of the cardiac tissue revealed intermittent claudin-5-claudin-5 interactions in trans via their extracellular part and crossing the basement membrane. Finally, we found a loss of crest structures and crest-crest contacts in diseased human CMs and in an experimental mouse model of left ventricle barometric overload.Overall, these results provide the first evidence for the existence of differential CM surface crests in the cardiac tissue as well as the existence of CM-CM direct physical contacts at their lateral face through crest-crest interactions. We propose a model in which this specific 3D organization of the CM lateral membrane ensures the myofibril/myofiber alignment and the overall cardiac tissue cohesion. A potential role in the control of sarcomere relaxation and of diastolic ventricular dysfunction is also discussed. Whether the loss of CM surface crests constitutes an initial and common event leading to the CM degeneration and the setting of heart failure will need further investigation.
Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication
Authors: Ka Shing Cheung, Esther W Chan, Angel Y S Wong, Lijia Chen, Wai Kay Seto, Ian C K Wong, Wai K Leung
Journal: JNCI Journal of the National Cancer Institute (2018)

Although prior studies showed metformin could reduce gastric cancer (GC) risk in patients with diabetes mellitus, they failed to adjust for Helicobacter pylori infection and glycemic control. We aimed to investigate whether metformin reduced GC risk in H. pylori-eradicated diabetic patients and its association with glycemic control. This was a territory-wide cohort study using hospital registry database, recruiting all diabetic patients who were prescribed clarithromycin-based triple therapy for H. pylori infection from 2003 to 2012. Subjects were observed from H. pylori therapy prescription until GC diagnosis, death, or end of study (December 2015). Exclusion criteria included GC diagnosed within first year of H. pylori therapy, prior history of GC or gastrectomy, and failure of H. pylori eradication. The hazard ratio (HR) of GC with metformin (defined as at least 180-day use) was estimated by Cox model with propensity score adjustment for covariates (age, sex, comorbidities, medications [including insulin], and time-weighted average hemoglobin A1c [HbA1c]). All statistical tests were two-sided. During a median follow-up of 7.1 years (IQR = 4.7–9.8), 37 (0.51%) of 7266 diabetic patients developed GC at a median age of 76.4 years (IQR = 64.8–81.5 years). Metformin use was associated with a reduced GC risk (adjusted HR = 0.49, 95% CI = 0.24 to 0.98). There was a trend towards a lower GC risk with increasing duration (Ptrend = .01) and dose of metformin (Ptrend = .02). HbA1c level was not an independent risk factor for GC. Metformin use was associated with a lower GC risk among H. pylori-eradicated diabetic patients in a duration- and dose-response manner, which was independent of HbA1c level.
Sitravatinib demonstrates activity in patients with novel genetic alterations that inactivate CBL
Authors: L. Bazhenova, R.D. Carvajal, B.C. Cho, K. Eaton, S. Goel, R.S. Heist, M. Ingham, D. Wang, T. Werner, S. Neuteboom, D. Potvin, I. Chen, J. Christensen, R. Chao, A. Alva
Journal: Annals of Oncology (2018)
City Living and Psychotic Disorders—Implications of Global Heterogeneity for Theory Development
Authors: James B. Kirkbride, Katherine M. Keyes, Ezra Susser
Journal: JAMA Psychiatry (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Index BRCA1/2 testing under a multidisciplinary program
Authors: D.H.R. Machado, S. Fragoso, A. Opinião, A. Clara, S. Bento, A.C. Luís, I. Miguel, S. Santos, P. Machado, P. Rodrigues, J. Parreira, F. Vaz
Journal: Annals of Oncology (2018)
GW29-e0868 Left Main Bifurcation Stenting Assessed by Computational Fluid Dynamic: the Impact on Wall Shear Stress Forces Depends on Both Specific Techniques and Bifurcation Angles
Authors: Gianluca Rigatelli, Marco Zuni, Vu Ha Thuy Vi, Duong Danh Nguyen Hien, Thao Dang, Thach Nguyen
Journal: Journal of the American College of Cardiology (2018)
Abstract 16675: Rapid Pulmonary Vein Isolation Using a Novel Diamond Tip Temperature Controlled Irrigated RF Catheter: First-in-man Clinical Experience
Authors: Jin Iwasawa, Jacob S Koruth, Petr Neuzil, Jan Petru, Stepan Kralovec, Vivek Y Reddy
Journal: Circulation (2016)

Introduction: A novel irrigated RF catheter with a diamond tip (for rapid cooling by virtue of its high thermal diffusivity) and six surface thermocouples (that reflect tissue temperature) allows o...
Insurer Coverage of Nonpharmacological Treatments for Low Back Pain—Time for a Change
Authors: Christine M. Goertz, Steven Z. George
Journal: JAMA Network Open (2018)

James Heyward, MPH; Christopher M. Jones, PharmD, MPH; Wilson M. Compton, MD, MPE; Dora H. Lin, MHS; Jan L. Losby, PhD, MSW; Irene B. Murimi, PhD, MA; Grant T. Baldwin, PhD, MPH; Jeromie M. Ballreich, PhD, MHS; David A. Thomas, PhD; Mark C. Bicket, MD; Linda Porter, PhD; Jonothan C. Tierce, CPhil; G. Caleb Alexander, MD, MS
GW29-e1290 Relationship between the Thrombus on Device and Selection of Anticoagulant Drugs after Left Arial Appendage Closure
Authors: Zhiqing Qiao, Heng Ge, Ziyong Hao, Lisheng Jiang, Zheng Li, Xinhua Wang, Xuedong Shen, Ben He
Journal: Journal of the American College of Cardiology (2018)
Polymer Self‐Assembled BMSCs with Cancer Tropism and Programmed Homing
Authors: Shuyi Zhang, Yuqing Liu, Soroosh Derakhshanfar, Wanming He, Qiong Huang, Shumin Dong, Jinjun Rao, Gao‐Xing Luo, Wen Zhong, Wangjun Liao, Min Shi, Malcolm Xing
Journal: Advanced Healthcare Materials (2018)

Targeted therapy can improve the accuracy of diagnosis and treatment in the field of cancer management. Cellular surface engineering can enhance cell functions via mounting functional molecules onto cellular membranes. A novel amphiphilic hyperbranched polymer (AHP) conjugated with oleic acid (OA) and tumor-targeted ligand folic acid (FA) is employed. The lipophilic chain can self-assemble and infuse with the cytomembrane of bone marrow mesenchymal stem cells (BMSCs) with the end of FA left on the outside for targeting. The polymer tailored BMSCs can enhance tumor tropism in gastric cancer. BMSCs are characterized by the low immunogenicity and tumor tropism, which makes them promising targeting carriers. Regarding the integrated advantages of these two vectors, it is demonstrated that the functional amphiphilic AHP-OA-FA enhances the tumor tropism of BMSCs. Flow cytometry, standard MTT assay, and wound-healing assay show that AHP-OA-FA has no influence on CD expression, proliferative capacity, and cell motility of BMSCs, respectively. Furthermore, in vitro transwell assay and ex vivo fluorescence image verify that AHP-OA-FA enhances tumor tropism of BMSCs compared to BMSCs and AHP-OA-Rhodamine B-BMSCs. Finally, histological analysis demonstrates that AHP-OA-FA causes no damage to major organs. The results of this study suggest that living BMSCs self-assembled with a polymer might be a promising vehicle for targeted delivery to cancer cells.