tbuckley/cabot-search huggingface dataset:
The Future of Surveillance in the Context of Cancer Predisposition: Through the Murky Looking Glass
Authors: David Malkin, Kim E. Nichols, Joshua D. Schiffman, Sharon E. Plon, Garrett M. Brodeur
Journal: Clinical Cancer Research (2017)

Abstract At least 10% of children with cancer harbor a disease-associated pathogenic variant in a known cancer predisposition gene. It is widely accepted that pathogenic variants affecting other genes, epigenetic factors, or abnormalities in additional gene products may contribute to the etiology of many more childhood cancers. Effective preventive measures exist for only a few cancer types associated with predisposing conditions, but the development and implementation of surveillance protocols aimed at reducing morbidity and mortality in at-risk children through the early detection of cancer has emerged as an important clinical tool. The articles in this Clinical Cancer Research series present international consensus generated recommendations for surveillance for a wide spectrum of cancer predisposition syndromes affecting children. In this article, we explore the challenges and opportunities for researchers and practitioners in the many fields affiliated with pediatric cancer, and we offer insights into what the future might hold as we continue our efforts to mitigate the impact of cancer susceptibility on children, their families and society. Clin Cancer Res; 23(21); e133–e7. ©2017 AACR. See all articles in the online-only CCR Pediatric Oncology Series.
PS04.03 LUME-Meso Phase II/III Study: Nintedanib + Pemetrexed/Cisplatin in Chemo-Naïve Patients with Malignant Pleural Mesothelioma
Authors: G. Scagliotti, R. Gaafar, A. Nowak, A. Tsao, N. Vogelzang, K. Kuribayashi, D. Velema, N. Morsli, S. Popat
Journal: Journal of Thoracic Oncology (2017)
TCT-145 Influence of Cachexia on Mortality after Transcatheter Aortic Valve Implantation in Patients with Severe Aortic Valve Stenosis
Authors: Lisa Voigtländer, Florian Deuschl, Niklas Schofer, Nicole Rübsamen, Moritz Seiffert, Daniel Kalbacher, Yvonne Schneeberger, Johannes Schirmer, Hermann Reichenspurner, Stefan Blankenberg, Lenard Conradi, Ulrich Schäfer
Journal: Journal of the American College of Cardiology (2017)
Le rapport de l’OMS sur la santé en Europe confirme le lien entre développement socio-économique et santé
Authors: M. S. Vilayleck
Journal: Eurosurveillance (2002)

Plus de 300 delegues, dont 20 ministres de la sante, ont participe a la 52e session du Comite regional de l’Organisation Mondiale de la Sante (OMS) qui s’est deroule a Copenhague (Danemark) du 16 au 19 septembre. A cette occasion, le rapport 2002 sur la sante en Europe a ete rendu public. Ce document confirme les liens etroits entre le developpement socio-economique, la sante et l’equite, dans la Region europeenne de l’Organisation Mondiale de la Sante (OMS), qui rassemble 51 Etats membres et compte quelques 870 millions d’habitants. Bien que les niveaux globaux de sante dans la Region figurent parmi les plus eleves de la planete, le rapport fait etat d’ecarts grandissant entre les pays, et au sein meme de chaque pays(www.euro.who.int/europeanhealthreport).
Guidelines for the management of acne: recommendations from a French multidisciplinary group
Authors: L. Le Cleach, B. Lebrun-Vignes, A. Bachelot, F. Beer, P. Berger, S. Brugère, M. Chastaing, G. Do-Pham, T. Ferry, J. Gand-Gavanou, B. Guigues, O. Join-Lambert, P. Henry, R. Khallouf, E. Lavie, A. Maruani, O. Romain, B. Sassolas, V.T. Tran, B. Guillot
Journal: British Journal of Dermatology (2017)

Linked Comment: Tan. Br J Dermatol 2017; 177: 892–893
Abstract 17600: Risk Stratification Using Biomarker for Fatal Arrhythmic Events Following Acute Myocardial Infarction Complicated With Left Ventricular Dysfunction in the Reperfusion Era
Authors: Nao Konagai, Yasuhide Asaumi, Tatsuhiro Shibata, Noriaki Moriyama, Kunihiro Nishimura, Takahiro Nakashima, Shouji Kawakami, Masashi Fujino, Kazuhiro Nakao, Toshiyuki Nagai, Kensaku Nishihira, Reon Kumasaka, Tetsuo Arakawa, Tomoaki Kanaya, Yu Kataoka, Yoshio Tahara, Michio Nakanishi, Teruo Noguchi, Satoshi Yasuda
Journal: Circulation (2016)

Background: To stratify the patients with later fatal arrhythmia event (FAE) following acute myocardial infarction (AMI), its determinants in the reperfusion era still remain uncertain. Methods: Am...
Understanding adrenal crisis
Authors: Karin Amrein, Gennaro Martucci, Stefanie Hahner
Journal: Intensive Care Medicine (2017)

Incidence and mortalityApproximately 5-17 cases of adrenal crisis (AC) occur per 100 patient years in patients with primary or secondary adrenal insufficiency (AI) [1,2].The mortality rate is estimated to be between 0.5% and 2%.Norwegian data indicate that overall, 1 in 7 patients with Addison's disease eventually dies from AC.It is estimated that AC will account for 5500-10,600 excess deaths in the European Union in the next decade [3].Often, these are preventable deaths in relatively young patients in the emergency department (ED) or intensive care unit (ICU) occurring from cardiorespiratory arrest in hypovolemic shock after delayed or insufficient steroid replacement, contributing to the excess mortality in patients at risk.Adequate treatment of AC using stress-dose intravenous steroids is often delayed, even when AI is known and patients present their emergency card to EDs or retrieval services (European Steroid Emergency Card www.endocrinology.org/adrenal-crisis
International Assessment of Event-Free Survival at 24 Months and Subsequent Survival in Peripheral T-Cell Lymphoma
Authors: Matthew J. Maurer, Fredrik Ellin, Line Srour, Mats Jerkeman, N. Nora Bennani, Joseph M. Connors, Graham W. Slack, Karin E. Smedby, Stephen M. Ansell, Brian K. Link, James R. Cerhan, Thomas Relander, Kerry J. Savage, Andrew L. Feldman
Journal: Journal of Clinical Oncology (2017)

Purpose Peripheral T-cell lymphomas (PTCLs) have aggressive clinical behavior. We have previously shown that event-free survival (EFS) at 24 months (EFS24) is a clinically useful end point in diffuse large B-cell lymphoma. Here, we assess EFS24 and subsequent overall survival (OS) in large, multinational PTCL cohorts. Patients and Methods Patients with systemic PTCL newly diagnosed from 2000 to 2012 and treated with curative intent were included from the United States and Sweden (initial cohorts) and from Canada (replication cohort). EFS was defined as time from date of diagnosis to progression after primary treatment, retreatment, or death. Subsequent OS was measured after achieving EFS24 or from the time of progression if it occurred within 24 months. OS rates were compared with the age-, sex-, and country-matched general population. Results Seven hundred seventy-five patients were included in the study (the median age at diagnosis was 64 years; 63% were men). Results were similar in the initial and replication cohorts, and a combined analysis was undertaken. Sixty-four percent of patients progressed within the first 24 months and had a median OS of only 4.9 months (5-year OS, 11%). In contrast, median OS after achieving EFS24 was not reached (5-year OS, 78%), although relapses within 5 years of achieving EFS24 occurred in 23% of patients. Superior outcomes after achieving EFS24 were observed in younger patients (≤ 60 years of age: 5-year OS, 91%). Conclusion EFS24 stratifies subsequent outcome in PTCL. Patients with PTCL with primary refractory disease or early relapse have extremely poor survival. However, more than one third of patients with PTCL remain in remission 2 years after diagnosis with encouraging subsequent OS, especially in younger patients. These marked differences in outcome suggest that EFS24 has utility for patient counseling, study design, and risk stratification in PTCL.
Brain Metastases in Lung Cancer With Targetable Mutations—Reply
Authors: Paul W. Sperduto, Minesh P. Mehta
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial
Authors: Rasha Al-Lamee, David Thompson, Hakim-Moulay Dehbi, Sayan Sen, Kare Tang, John Davies, Thomas Keeble, Michael Mielewczik, Raffi Kaprielian, Iqbal S Malik, Sukhjinder S Nijjer, Ricardo Petraco, Christopher Cook, Yousif Ahmad, James Howard, Christopher Baker, Andrew Sharp, Robert Gerber, Suneel Talwar, Ravi Assomull, Jamil Mayet, Roland Wensel, David Collier, Matthew Shun-Shin, Simon A Thom, Justin E Davies, Darrel P Francis, Rasha Al-Lamee, David Thompson, Sayan Sen, Kare Tang, John Davies, Thomas Keeble, Raffi Kaprielian, Iqbal S Malik, Sukhjinder S Nijjer, Ricardo Petraco, Christopher Cook, Yousif Ahmad, James Howard, Matthew Shun-Shin, Amarjit Sethi, Christopher Baker, Andrew Sharp, Punit Ramrakha, Robert Gerber, Suneel Talwar, Ravi Assomull, Rodney Foale, Jamil Mayet, Roland Wensel, Simon A Thom, Justin E Davies, Darrel P Francis, Ramzi Khamis, Nearchos Hadjiloizou, Masood Khan, Jaspal Kooner, Michael Bellamy, Ghada Mikhail, Piers Clifford, Peter O'Kane, Terry Levy, Rosie Swallow
Journal: The Lancet (2017)
Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in patients with primary CNS lymphoma: results of the second randomisation of the International Extranodal Lymphoma Study Group-32 phase 2 trial
Authors: Andrés J M Ferreri, Kate Cwynarski, Elisa Pulczynski, Christopher P Fox, Elisabeth Schorb, Paul La Rosée, Mascha Binder, Alberto Fabbri, Valter Torri, Eleonora Minacapelli, Monica Falautano, Fiorella Ilariucci, Achille Ambrosetti, Alexander Roth, Claire Hemmaway, Peter Johnson, Kim M Linton, Tobias Pukrop, Jette Sønderskov Gørløv, Monica Balzarotti, Georg Hess, Ulrich Keller, Stephan Stilgenbauer, Jens Panse, Alessandra Tucci, Lorella Orsucci, Francesco Pisani, Alessandro Levis, Stefan W Krause, Hans J Schmoll, Bernd Hertenstein, Mathias Rummel, Jeffery Smith, Michael Pfreundschuh, Giuseppina Cabras, Francesco Angrilli, Maurilio Ponzoni, Martina Deckert, Letterio S Politi, Jürgen Finke, Michele Reni, Franco Cavalli, Emanuele Zucca, Gerald Illerhaus
Journal: The Lancet Haematology (2017)
Seeing the elephant: Parsimony, functionalism, and the emergent design of contempt and other sentiments
Authors: Matthew M. Gervais, Daniel M. T. Fessler
Journal: Behavioral and Brain Sciences (2017)

Abstract The target article argues that contempt is a sentiment, and that sentiments are the deep structure of social affect. The 26 commentaries meet these claims with a range of exciting extensions and applications, as well as critiques. Most significantly, we reply that construction and emergence are necessary for, not incompatible with, evolved design, while parsimony requires explanatory adequacy and predictive accuracy, not mere simplicity.
Surto de triquiníase humana, em Itália, associada ao consumo de carne de cavalo
Authors: E Pozio, D Sacchini, P Boni, A Tamburrini, F Alberici, F Paterlini
Journal: Eurosurveillance (1998)

A triquiniase e endemica entre os mamiferos selvagens em Italia, embora cause poucas infestacoes no homem geralmente devidas ao consumo de carne de porcos apascentados em regioes selvagens ou de javalis (1). Em Italia, a maior parte dos casos de triquiniase humana sao devidos ao consumo de carne de cavalo (902 casos em quatro surtos de 1975 a 1990)(2). A 22 de Janeiro de 1998, foram importados 27 cavalos da Polonia para serem abatidos no matadouro duma empresa privada em Brescia, no norte de Italia.
68Ga-DOTA-TATE PET/CT for Molecular Imaging of Somatostatin Receptor Expression in Extra-adrenal Paraganglioma in a Case of Complete Carney Triad
Authors: Thorsten Derlin, Dagmar Hartung, Katja Hueper
Journal: Clinical Nuclear Medicine (2017)

Carney triad is a very rare syndrome characterized by the synchronous or metachronous occurrence of gastrointestinal stromal tumors, pulmonary chondroma, and extra-adrenal paraganglioma. We present the case of a 36-year-old woman with complete Carney triad who underwent a Ga-DOTA-TATE PET/CT scan for restaging of metastasizing extra-adrenal paraganglioma and for evaluation of targeted radionuclide therapy potential. On the Ga-DOTA-TATE PET scan, increased tracer accumulation was observed in paraganglioma metastases. This case highlights the usefulness of Ga-DOTA-TATE PET/CT for restaging of metastasizing paraganglioma in Carney triad and the option of targeted radionuclide therapy in this entity.
The Distribution of T Memory Stem Cells in Cord Blood, Peripheral Blood from Healthy Individuals and Patients with Leukemia/Lymphoma
Authors: Ling Xu, Jiaxiong Tan, Yikai Zhang, Jing Lai, Yuhong Lu, Danlin Yao, Zhenyi Jin, Shaohua Chen, Lijian Yang, Xianfeng Zha, Yangqiu Li
Journal: Blood (2016)
Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase
Authors: R Jarrett, M Salio, A Lloyd-Lavery, S Subramaniam, E Bourgeois, C Archer, A Cheung, C Hardman, D Chandler, M Salimi, D Gutowska-Owsiak, J B de la Serna, P Fallon, H Jolin, A Mckenzie, A Dziembowski, E Podobas, W Bal, D Johnson, D B Moody, V Cerundolo, G Ogg
Journal: British Journal of Dermatology (2016)
PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models
Authors: Terrence F. Meehan, Nathalie Conte, Theodore Goldstein, Giorgio Inghirami, Mark A. Murakami, Sebastian Brabetz, Zhiping Gu, Jeffrey A. Wiser, Patrick Dunn, Dale A. Begley, Debra M. Krupke, Andrea Bertotti, Alejandra Bruna, Matthew H. Brush, Annette T. Byrne, Carlos Caldas, Amanda L. Christie, Dominic A. Clark, Heidi Dowst, Jonathan R. Dry, James H. Doroshow, Olivier Duchamp, Yvonne A. Evrard, Stephane Ferretti, Kristopher K. Frese, Neal C. Goodwin, Danielle Greenawalt, Melissa A. Haendel, Els Hermans, Peter J. Houghton, Jos Jonkers, Kristel Kemper, Tin O. Khor, Michael T. Lewis, K.C. Kent Lloyd, Jeremy Mason, Enzo Medico, Steven B. Neuhauser, James M. Olson, Daniel S. Peeper, Oscar M. Rueda, Je Kyung Seong, Livio Trusolino, Emilie Vinolo, Robert J. Wechsler-Reya, David M. Weinstock, Alana Welm, S. John Weroha, Frédéric Amant, Stefan M. Pfister, Marcel Kool, Helen Parkinson, Atul J. Butte, Carol J. Bult
Journal: Cancer Research (2017)

Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models.
Study of Host-Virus Relationship. I. Light, Phase, and Fluorescence Microscopy of Mouse-Embryo Cells Infected With Polyoma Virus&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Elizabeth Bereczky, Leon Dmochowski, Clifford E. Grey
Journal: JNCI Journal of the National Cancer Institute (1961)

Comparative studies by means of light, phase-contrast, and fluorescence microscopy were carried out on C3H/An/Dm mouse-embryo cell cultures infected with SE polyoma virus. The nature and sequence of changes after infection were studied. As seen by phase microscopy, inclusions appear in the nuclei of the infected cells, 4 to 5 days after infection. One type of inclusion, centrally or eccentrically located, is composed of dense, homogeneous material and is frequently surrounded by a clear zone. The other type of inclusion consists of either dense strands or amorphous, dense, scattered material. Increase and margination of chromatin material are frequently observed. The inclusions increase in size and density before the lysis of cells. Both types of inclusions stain yellow for deoxyribonucleic acid (DNA) with acridine orange fluorescent dye. The staining is not removed by treatment with deoxyribonuclease (DNase) or pepsin. Pretreatment with pepsin, followed by DNase digestion, removes the DNA stain, which indicates the possible viral nature of these inclusions. By the Feulgen method, both types of inclusions at first stain delicate pink and lavender-pink at the height of infection. Feulgen-negative material surrounds the dense areas of type-1 inclusions and is present between the dense strands or amorphous material of type-2 inclusions. During the last stages of infection, inclusions of similar staining properties are found occasionally in the cytoplasm of the infected cells. Electron microscopy of ultrathin sections of similar cells or adjacent thin sections of cells with the two types of intranuclear inclusions has revealed characteristic polyoma-virus particles within these inclusions. The chemical nature of the polyoma virus is discussed in the light of these observations.
O impacto do teste de ácidos nucleicos (NAT) em Italia de 2001 a 2003
Authors: C Velati, L Fomiatti, L Baruffi, L Romanò, A Zanetti
Journal: Eurosurveillance (2005)

Em Italia, o uso do teste de acidos nucleicos (NAT) nas doacoes de sangue e obrigatario desde o 28 de Junho de 2002, embora fora utilizada esta tecnica desde 2001 de modo experimental. Durante o periode de transicao tambem estava permitido o uso de testes enzimaticos (EIA) para a deteccao do antigeno do core do virus da hepatite C (Ag HBc). Considerando o grande numero de centros de transfusao de sangue em Italia, foi necessario reorganizar a validacao biologica das doacoes de sangue com uma centralizacao parcial do teste pelo NAT. O “Gruppo Italiano per lo Studio delle Malattie Trasmissibili con la Trasfusione” (Grupo Italiano de Estudo de Doencas Transmissiveis por Transfusao) realizou um estudo nacional para evaluar o NAT baseado na recolha annual de dados por meio de um questionario enviado a todos os centros. Durante os tres primeiros anos, 219 centros de transfusao responderam ao inquerito. 
Entre Janeiro de 2001 e Dezembro de 2003, foram testadas para o virus da hepatite C (VHC) 3.894.894 doacoes de sangue e 2.186.468 para o VIH. Doze testes eram positivos para o VHC, o que representa uma melhoria para o NAT comparado com os testes de anticorpos de 3,1 por milhao de doacoes para o VHC e de 1,8 por milhao de doacoes para o VIH. Cinco dos 12 dadores VHC positivos e anti-VHC negativos tinham valores de TLA anormais; estas doacoes teriam sido recusadas mesmo sem NAT. Assim, o resultado final do NAT para o VHC nao e mais do que 1,79 por milhao de doacoes. Em Italia, desde a implementacao do NAT, o risco residual de transmissao do VHC ou do VIH por transfusao de sangue e extremamente baixo.
Rational Design of a New Self‐Codelivery System from Redox‐Sensitive Camptothecin–Cytarabine Conjugate Assembly for Effectively Synergistic Anticancer Therapy
Authors: Wenxiu He, Xu Hu, Wei Jiang, Ruiling Liu, Di Zhang, Jing Zhang, Zhonghao Li, Yuxia Luan
Journal: Advanced Healthcare Materials (2017)

Herein, two careful selected anticancer drugs camptothecin (CPT) and cytarabine (Ara-C) with different biological action mechanisms and different water solubility are conjugated together through a glutathione (GSH) cleavable disulfide bond to construct a redox-sensitive drug-drug conjugate, which can self-assemble into nanoparticles, thus notably improving the water solubility of CPT and the cell membrane permeability of Ara-C. Compared with free drugs, the self-assembled CPT-ss-Ara nanoparticles can concentrate in tumor tissues through the enhanced permeability and retention (EPR) effect, then they can be rapidly internalized by tumor cells and degrade into free drugs for killing the tumor cells when exposed to the reductive environment (GSH) of tumor cells, thereby reducing the injury to normal cells. Meanwhile, the CPT-ss-Ara nanoparticles can effectively protect CPT and Ara-C molecules from biological inactivation before their arrival in tumor microenvironment since free CPT and Ara-C are easy to partly lose their therapy efficacy due to their structure degradation in blood circulation. The in vitro and in vivo anticancer experimental results indicate that simultaneous release of free CPT and Ara-C can realize synergistic chemotherapy effects, thus markedly improve their anticancer activity. Therefore, our designed carrier-free, redox-sensitive CPT-ss-Ara nanoparticles might have promising clinical application to combat cancers.
Rapid Field Response to a Cluster of Illnesses and Deaths — Sinoe County, Liberia, April–May, 2017
Authors: John Doedeh, Joseph Asamoah Frimpong, Kwuakuan D.M. Yealue, Himiede W. Wilson, Youhn Konway, Samson Q. Wiah, Vivian Doedeh, Umaru Bao, George Seneh, Lawrence Gorwor, Sylvester Toe, Emmanuel Ghartey, Lawrence Larway, Dedesco Gweh, Philemon Gonotee, Thomas Paasewe, George Tamatai, James Yarkeh, Samuel Smith, Annette Brima-Davis, George Dauda, Thomas Monger, Leleh W. Gornor-Pewu, Siafa Lombeh, Jeremias Naiene, Nathaniel Dovillie, Mark Korvayan, Geraldine George, Garrison Kerwillain, Ralph Jetoh, Suzanne Friesen, Carl Kinkade, Victoria Katawera, Maame Amo-Addae, Roseline N. George, Miatta Z. Gbanya, E. Kainne Dokubo
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

On April 25, 2017, the Sinoe County Health Team (CHT) notified the Liberia Ministry of Health (MoH) and the National Public Health Institute of Liberia of an unknown illness among 14 persons that resulted in eight deaths in Sinoe County. On April 26, the National Rapid Response Team and epidemiologists from CDC, the World Health Organization (WHO) and the African Field Epidemiology Network (AFENET) in Liberia were deployed to support the county-led response. Measures were immediately implemented to identify all cases, ascertain the cause of illness, and control the outbreak. Illness was associated with attendance at a funeral event, and laboratory testing confirmed Neisseria meningitidis in biologic specimens from cases. The 2014-2015 Ebola virus disease (Ebola) outbreak in West Africa devastated Liberia's already fragile health system, and it took many months for the country to mount an effective response to control the outbreak. Substantial efforts have been made to strengthen Liberia's health system to prevent, detect, and respond to health threats. The rapid and efficient field response to this outbreak of N. meningitidis resulted in implementation of appropriate steps to prevent a widespread outbreak and reflects improved public health and outbreak response capacity in Liberia.