SAT0577 Evalatuion of sarcopenia multidimensionally in patients with knee osteoarthritis
Authors: S. Gümrük Aslan, M. Saraçoğlu, H. Genç, B. D.Çakit, B. Nacir
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Osteoarthritis(OA) is a noninflammatory chronic degenerative disease.The rate of development of sarcopenia has been increased in patients with OA. <h3>Objectives</h3> In this study,we evaluated the presence of sarcopenia multidimensionally in patients with knee osteoarthritis (OA) using clinical,ultrasonographic and biochemical parameters,and in this respect, it was aimed to investigate the relation between OA and sarcopenia and to identify the most practical,easily accessible and inexpensive method for investigating sarcopenia. <h3>Methods</h3> 102 patients with clinical and radiological diagnosis of knee osteoarthritis and 33 healthy control subjects were included in the study.A total of 135 subjects were evaluated by the European Working Group on Sarcopenia in Older People (EWGSOP) for the diagnosis of sarcopenia.The first group consists of (OA) patients with sarcopenia, the second group consist of OA patients without sarcopenia and the third group is controls subjects.Dual-X-ray absorptiometry (DEXA) is used to measure Body composition parameters and muscle mass measurements, isometric muscle strength evaluations, hand grip strength and walking speeds for diagnosis of sarcopenia. Short form −36 (SF-36) The Nutritional Assesment-short form (MNA), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the International Physical Assessment Questionnaire Short Form (IPAQ-SF) and the Centre for Epidemiologic Studies Depression Scale (CES-D scale) were administered to every patients. <h3>Results</h3> The mean age of the group with sarcopenia was statistically higher than the other two groups (p&lt;0.001). The weight, body mass index (BMI), waist circumference, upper mid-arm circumference, thigh and leg circumference of osteoarthritis (OA) patients with sarcopenia were statistically lower than those of non-sarcopenic and control group (p&lt;0.01 p&lt;0.001).Body composition parameters results showed that sarcopenic patients had statistically lower values as fat mass, lean body mass and Skeletal Muscle Index (p&lt;0.001, p=0.001, p&lt;0.001, respectively) than those of non-sarcopenic and control group.It was determined that body composition values measured with DEXA, ultrasonogrphic measures, isokinetic muscle strength assessment, hand grip strength and gaid speed had predictive values for sarcopenia. <h3>Conclusions</h3> We found that patients with sarcopenic OA were older, weaker, less powerful, undernourished, and restricted in their level of physical activity in the study in which we identified sarcopenia as approximately 12% in patients with osteoarthritis. Among the methods of determining sarcopenia, ultrasound becomes prominent with its practical, cheap and easily accessible features. We think that our results will increase the awareness of the presence of sarcopenia in OA patients. <h3>References</h3> [1] Kemmler W, Teschler M, Goisser S, Bebenek M, von Stengel S, Bollheimer LC, et al. Prevalence of sarcopenia in Germany and the corresponding effect of osteoarthritis in females 70 years and older living in the community: results of the FORMoSA study. Clinical interventions in aging2015;10:1565. [2] Papalia R, Zampogna B, Torre G, Lanotte A, Vasta S, Albo E, et al. Sarcopenia and its relationship with osteoarthritis: risk factor or direct consequence?Musculoskeletal surgery2014;98:9–14. <h3>Disclosure of Interest</h3> None declared