Acquired C1 Esterase Inhibitor Deficiency
Authors: Teresa Caballero
Journal: Annals of Internal Medicine (2000)

Letters21 November 2000Acquired C1 Esterase Inhibitor DeficiencyTeresa Caballero, MD, PhD, Maria Concepcion Lopez-Serrano, MD, PhD, and Margarita Lopez-Trascasa, PhDTeresa Caballero, MD, PhDHospital Universitario La Paz; 28046 Madrid, Spain (Caballero, Concepcion Lopez-Serrano, Lopez-Trascasa)Search for more papers by this author, Maria Concepcion Lopez-Serrano, MD, PhDHospital Universitario La Paz; 28046 Madrid, Spain (Caballero, Concepcion Lopez-Serrano, Lopez-Trascasa)Search for more papers by this author, and Margarita Lopez-Trascasa, PhDHospital Universitario La Paz; 28046 Madrid, Spain (Caballero, Concepcion Lopez-Serrano, Lopez-Trascasa)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-10-200011210-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We disagree with Markovic and colleagues' treatment recommendations for acquired C1 esterase deficiency (1) because they could lead to mistreatment of patients with this illness and life-threatening situations.The authors draw conclusions from 22 cases with supposed “acquired C1 esterase inhibitor deficiency angioedema” but present only partial results of two cases that have no clearly documented diagnosis. Acute angioedema attacks were treated with antihistamines, corticosteroids, or epinephrine. Symptom resolution was attributed to this therapy, but the cause-and-effect relationship was not clearly demonstrated (the attacks could have resolved spontaneously). Moreover, the authors did not document these treatments with ...References1. Markovic SN, Inwards DJ, Frigas EA, Phyliky RP. Acquired C1 esterase inhibitor deficiency. Ann Intern Med. 2000;132:144-50. LinkGoogle Scholar2. Waytes AT, Rosen FS, Frank MM. Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate. N Engl J Med. 1996;334:1630-4. CrossrefMedlineGoogle Scholar3. Agostoni A, Cicardi M. Hereditary and acquired C1-inhibitor deficiency: biological and clinical characteristics in 235 patients. Medicine Baltimore. 1992;71:206-15. CrossrefMedlineGoogle Scholar4. Carreer FM. The C1 inhibitor deficiency. A review. Eur J Clin Chem Clin Biochem. 1992;30:793-807. MedlineGoogle Scholar5. Cicardi M, Bergamaschini L, Cugno M, Beretta A, Zingale LC, Colombo M, et al . Pathogenetic and clinical aspects of C1 inhibitor deficiency. Immunobiology. 1998;199:366-76. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Hospital Universitario La Paz; 28046 Madrid, Spain (Caballero, Concepcion Lopez-Serrano, Lopez-Trascasa) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAcquired C1 Esterase Inhibitor Deficiency Svetomir N. Markovic , David J. Inwards , Evangelos A. Frigas , and Robert P. Phyliky Acquired C1 Esterase Inhibitor Deficiency Thomas Grünewald Acquired C1 Esterase Inhibitor Deficiency Marco Cicardi , Angelo Agostoni , and Alvin E. Davis III Acquired C1 Esterase Inhibitor Deficiency Allen P. Kaplan Acquired C1 Esterase Inhibitor Deficiency Antal Csepregi and Elemér Nemesánszky Acquired C1 Esterase Inhibitor Deficiency Svetomir N. Markovic , David J. Inwards , and Robert P. Phyliky Metrics Cited ByProtease inhibitors in the treatment of hereditary angioedema 21 November 2000Volume 133, Issue 10Page: 837KeywordsAndrogensAntigensAntihistaminesDrugsEpinephrineEsterasesGenetic diseasesPatient advocacyProphylaxis ePublished: 21 November 2000 Issue Published: 21 November 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...