tbuckley/cabot-search huggingface dataset:
Abstract 20556: Temporal Trends in Incidence of Malignancy in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.
Authors: Konstantinos V Voudris, Mladen I Vidovich
Journal: Circulation (2016)

Background:  Cancer patients are believed to be exposed to increased cardiovascular risk as a result of potential toxicity from radiation and chemotherapy. Beyond traditional risk factors for acute myocardial infarction (AMI), cancer therapies may cause significant injury to the vasculature affecting overall outcomes. We examined temporal trends in incidence of malignancy in patients presenting with AMI requiring Percutaneous Coronary Intervention (PCI).   Methods:  Subjects were obtained from the HCUP-Nationwide Inpatient Sample (NIS) database for the years 2002-2013. ICD-9-CM procedure code were used to identify patients with Genitourinary, Gastrointestinal, Pulmonary, Skin, Breast and Hematologic malignancies treated with PCI for AMI.   Results:  Among 3,445,430 patients undergoing PCI for AMI during the study period, 236,101 (6.9%) had a history of malignancy. Genitourinary cancer was the most prevalent type increasing by 55.4% over the twelve-year period from 2.05% of the cases in 2002 to 3.18% in 2013. The highest increase, 160.2%, was observed in Skin cancer; incidence from 0.51% of the cases in 2002 to 1.33% in 2013, followed by Hematologic malignancies, 86.3% increase, from 0.56% of the cases in 2002 to 1.04% in 2013. Incidence of Gastrointestinal, Pulmonary and Breast malignancies were also elevated by 38.5%, 64.6% and 41.3% respectively. The reported increase in the incidence of malignancy was statistically significant in all subtypes over the years (P   Conclusion:  Hospital admissions for cancer patients presenting with AMI and requiring PCI increased significantly in the US during the last twelve years. Genitourinary malignancies are the most frequent subtype, while skin malignancies are the fastest increasing one.
TCT-573 Characterization of edge effects with second-generation drug-eluting absorbable metal scaffold assessed by optical coherence tomography, intravascular ultrasound grayscale, and virtual histology at 6- and 12-month. A Biosolve II substudy
Authors: Alexandre Hideo-Kajita, Hector Garcia-Garcia, Michael Haude, Hüseyin Ince, Alexandre Abizaid, Ralph Toelg, Pedro A. Lemos, Evald Christiansen, William Wijns, Franz-Josef Neumann, Eric Eeckhout, Soo Teik LIM, Javier Escaned, Viana Azizi, Kayode Kuku, Ron Waksman
Journal: Journal of the American College of Cardiology (2017)
Pooled RCTs: In symptomatic carotid stenosis, endarterectomy had lower periprocedural risk than stenting
Authors: Graeme J. Hankey
Journal: Annals of Internal Medicine (2017)

Source Citation Rantner B, Kollerits B, Roubin GS, et al; Carotid Stenosis Trialists' Collaboration. Early endarterectomy carries a lower procedural risk than early stenting in patients with symptomatic stenosis of the internal carotid artery: results from 4 randomized controlled trials. Stroke. 2017;48:1580-7. 28455318
Abstract 195: Kawasaki Disease in a four-year-old girl with History of Acute Myeloid Leukemia; Report of a Case and Literature Review
Authors: Reiko Kawai, Shinichi Takatsuki, Tomotaka Nakayama, Tomoka Sawa, Shun Yanai, Kazuyuki Naoi, Satoshi Ikehara, Hiroyuki Matsuura, Akira Ohara, Tsutomu Saji, Tsutomu Saji
Journal: Circulation (2015)

Background: Kawasaki disease (KD) and acute myeloid leukemia (AML) both occur predominantly in young children. However, considering that the incidence rate of cancer during 0-14 years of age in Japan is 10.1 per a hundred thousand and that of KD during 0-4 years of age is 260 per a hundred thousand, there is little possibility of the same individual developing 2 diseases. Both inside and outside Japan we found at least 19 case reports of KD some relevant to cancer. Herein, we report a case of KD in a four-year-old Japanese girl with history of AML. Case report: A four-year-old Japanese girl was diagnosed with KD at 3 days of illness. She had the medical history of AML-M7 at her age of 1. She had no chimeric genes and was classed as intermediate risk. She had been treated following JPLSG AML05 protocol including etoposide, cytarabine (Ara-C), mitoxantrone, idarubicin, methotrexate (MTX), hydrocortisone (HDC) and triple intrathecal therapy (Ara-C, MTX and HDC). More than 2 years had passed without recurrence since her last chemotherapy. When we diagnosed her as KD, laboratory findings showed WBC 15.5 х103/μl with 85% neutrophils, hematocrit 33.7%, platelet count 19.1x10 6 /μl, CRP 10.5mg/dl, serum albumin 3.8g/dl and BNP 12.2pg/ml. She responded well to IVIG (2g/kg) plus prednisolone (2mg/kg/day) and ASA (30mg/kg/day). Although BNP transiently had increased to 151.8pg/ml at 5 days after onset, neither coronary arterial abnormalities nor myocardial complications were detected at 1 year of illness. Conclusions: We experienced the rare case of KD in a four-year-old Japanese girl with history of AML. She responded well to IVIG and any cardiovascular complications were not detected at 1 year of illness. Referring to only this case, it is unclear whether the history of AML could influence developing and progress of KD or not. The possibility of the same individual developing KD during 0-4 years of age and cancer during 0-14 years of age would be 2.6 per 10 million in Japan. However, among three hundred thousand cumulative patients of KD in Japan, 14 cases have been reported that they had developed cancer during 0-14 years of age. To discuss the relation to character of cancer, chemotherapy and severity or compilations of KD, more case should be evaluated.
TCT-443 Geographical Variation in Patient Characteristics, Procedures and Clinical Outcomes after PCI of Left Main Coronary Artery Disease: Analysis from the EXCEL Trial
Authors: Aung Myat, Marie-Claude Morice, David Hildick-Smith, Adam De Belder, Uday Trivedi, David Kandzari, Nicholas Lembo, William Brown, Patrick Serruys, A. Pieter Kappetein, Joseph Sabik, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
TCT-313 Lens Changes Associated with Radiation in the Cardiac Catheterization Laboratory: An Update from the IC-CATARACT (CATaracts Attributed to Radiation in the CaTh Lab) Study
Authors: Judit Karacsonyi, Harilaos Brilakis, Aris Karatasakis, Roberto Martinez-Parachini, Barbara Anna Danek, Peter Tajti, Phuong-Khanh Nguyen-Trong, Aya Alame, Michele Roesle, Bavana Rangan, Kenneth Rosenfield, Roxana Mehran, Ehtisham Mahmud, Charles Chambers, Imre Ungi, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2017)
Dolutegravir as maintenance monotherapy for HIV (DOMONO): a phase 2, randomised non-inferiority trial
Authors: Ingeborg Wijting, Casper Rokx, Charles Boucher, Jeroen van Kampen, Suzan Pas, Theodora de Vries-Sluijs, Carolina Schurink, Hannelore Bax, Maarten Derksen, Eleni-Rosalina Andrinopoulou, Marchina van der Ende, Eric van Gorp, Jan Nouwen, Annelies Verbon, Wouter Bierman, Bart Rijnders
Journal: The Lancet HIV (2017)
Assessment of liver fibrosis with the gamma-glutamyl transpeptidase to platelet ratio: a multicentre validation in patients with HBV infection
Authors: Xiao-Jie Lu, Xiu-Hui Li, Zhao-Xin Yuan, Hai-Ying Sun, Xiao-Chen Wang, Xiaolong Qi, Xin Zhang, Beicheng Sun
Journal: Gut (2017)

We read with interest the study by Lemoine et al 1 in which the gamma-glutamyl transpeptidase (GGT) to platelet ratio (GPR) was developed to stage fibrosis in patients with chronic hepatitis B (CHB). This study concluded that GPR is more accurate than the aspartate aminotransferase to platelet ratio index (APRI) and Fib-4 to stage liver fibrosis in patients with CHB. As China is a highly endemic area of CHB with estimated >74 million hepatitis B surface antigen (HBsAg)-positive patients,2 3 we conducted this multicentre study to validate the diagnostic performance of GPR in Chinese patients with CHB.

Treatment-naive patients with positive HBsAg who underwent liver biopsy, Fibroscan (FS402, Echosens, France) and blood tests were included from three centres (Huai’an Fourth People’s Hospital, Huai’an, China (January 2012–April 2016), Beijing You-An Hospital, Capital Medical University, Beijing, China (January 2014–June 2016) and Hepatology Hospital of Jilin …
TCT-754 One-year clinical outcome of patients treated with Resolute Onyx versus Resolute Integrity: A Comparison of the HOST-ONYX and HOST-RESOLINTE Registries
Authors: Chee Hae Kim, Euijae Lee, Jeehoon Kang, Jung-Kyu Han, Han-Mo Yang, Kyung Woo (KW) Park, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2017)
TCT-49 Long-term valve function 5-9 years after transcatheter aortic valve implantation: data from the UK-TAVI Registry. On behalf of the National Institute for Cardiovascular Outcomes Research (NICOR)
Authors: Daniel Blackman, David Hildick-Smith, Philip Maccarthy, Stephen Brecker, Stephen Dorman, Stephen Hoole, Adrian Banning, Saib Khogali, Peter Ludman, David Roberts, Christopher Malkin, Cameron Dowling, Jessica Parker, Omar Aldalati, Justin Tay, Bernadette Moreby, Ayush khurana
Journal: Journal of the American College of Cardiology (2017)
Options for affordable pre-exposure prophylaxis (PrEP) in national HIV prevention programmes in Europe
Authors: Rosalind Coleman, Maria Prins
Journal: Eurosurveillance (2017)

Preview this article: Options for affordable pre-exposure prophylaxis (PrEP) in national HIV prevention programmes in Europe, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/22/42/eurosurv-22-42-1-1.gif
Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology
Authors: Yu-Han Chiu, Paige L. Williams, Matthew W. Gillman, Audrey J. Gaskins, Lidia Mínguez-Alarcón, Irene Souter, Thomas L. Toth, Jennifer B. Ford, Russ Hauser, Jorge E. Chavarro
Journal: JAMA Internal Medicine (2017)

<h3>Importance</h3> Animal experiments suggest that ingestion of pesticide mixtures at environmentally relevant concentrations decreases the number of live-born offspring. Whether the same is true in humans is unknown. <h3>Objective</h3> To examine the association of preconception intake of pesticide residues in fruits and vegetables (FVs) with outcomes of infertility treatment with assisted reproductive technologies (ART). <h3>Design, Setting, and Participants</h3> This analysis included 325 women who completed a diet assessment and subsequently underwent 541 ART cycles in the Environment and Reproductive Health (EARTH) prospective cohort study (2007-2016) at a fertility center at a teaching hospital. We categorized FVs as having high or low pesticide residues using a validated method based on surveillance data from the US Department of Agriculture. Cluster-weighted generalized estimating equations were used to analyze associations of high– and low–pesticide residue FV intake with ART outcomes. <h3>Main Outcomes and Measures</h3> Adjusted probabilities of clinical pregnancy and live birth per treatment cycle. <h3>Results</h3> In the 325 participants (mean [SD] age, 35.1 [4.0] y; body mass index, 24.1 [4.3]), mean (SD) intakes of high– and low–pesticide residue FVs were 1.7 (1.0) and 2.8 (1.6) servings/d, respectively. Greater intake of high–pesticide residue FVs was associated with a lower probability of clinical pregnancy and live birth. Compared with women in the lowest quartile of high-pesticide FV intake (&lt;1.0 servings/d), women in the highest quartile (≥2.3 servings/d) had 18% (95% CI, 5%-30%) lower probability of clinical pregnancy and 26% (95% CI, 13%-37%) lower probability of live birth. Intake of low–pesticide residue FVs was not significantly related to ART outcomes. <h3>Conclusions and Relevance</h3> Higher consumption of high–pesticide residue FVs was associated with lower probabilities of pregnancy and live birth following infertility treatment with ART. These data suggest that dietary pesticide exposure within the range of typical human exposure may be associated with adverse reproductive consequences.
TCT-86 Which patients are undergoing transcatheter tricuspid repair today? An update from the International Multicenter Transcatheter Tricuspid Valve Therapies (TriValve) Registry
Authors: Maurizio Taramasso, Rebecca Hahn, Hannes Alessandrini, Azeem Latib, Adrian Attinger, Daniel Braun, Eric Brochet, Christelle Calen, Kim Connelly, Paolo Denti, Florian Deuschl, Neil Fam, Christian Frerker, Jörg Hausleiter, Jean-Michel Juliard, Ryan Kaple, Karl-Heinz Kuck, Shingo Kuwata, Marco Ancona, Michael Mehr, Tamim Nazif, Georg Nickenig, Fabian Nietlispach, Joachim Schofer, Alberto Pozzoli, Ulrich Schäfer, Robert Schueler, Gilbert Tang, John Webb, Ermela Yzeiraj, Francesco Maisano, Martin Leon
Journal: Journal of the American College of Cardiology (2017)
Clinical and histopathological effects of heart failure drug therapy in advanced heart failure patients on chronic mechanical circulatory support
Authors: Anna B. Catino, Peter Ferrin, James Wever‐Pinzon, Benjamin D. Horne, Omar Wever‐Pinzon, Abdallah G. Kfoury, Lauren McCreath, Nikolaos A. Diakos, Stephen McKellar, Antigone Koliopoulou, Michael J. Bonios, Mohammad Al‐Sarie, Iosif Taleb, Elizabeth Dranow, James C. Fang, Stavros G. Drakos
Journal: European Journal of Heart Failure (2017)
Situación actual de la poliomielitis en Europa de cara a su erradicación
Authors: S Wassilak, G Oblapenko, S Dittmann
Journal: Eurosurveillance (1997)

En 1.988, la Asamblea Mundial de la Salud establecio el objetivo de erradicacion global de la poliomielitis por poliovirus salvaje en el ano 2.000. Las estrategias de la campana son: alcanzar y mantener altos niveles de cobertura de vacunacion sistematica en toda la poblacion; administrar inmunizacion suplementaria en campanas masivas denominadas dias de inmunizacion nacional (DIN) a ninos de corta edad, con independencia de su historial de vacunacion anterior; realizar una inmunizacion suplementaria de “erradicacion” en grupos de alto riesgo, mediante una labor a domicilio; y llevar a cabo una potente vigilancia de la paralisis flacida aguda (PFA) para detectar de inmediato todos los casos posibles de poliomielitis y facilitar datos virologicos que confirmen la ausencia de circulacion de poliovirus salvaje. En 1.994, se certifico la erradicacion de la poliomielitis en la region de las Americas de la OMS. Este informe presenta la situacion actual hacia dicho objetivo en los 51 paises de la Region Europea de la OMS, que incluye a todos los paises de los Nuevos Estados Independientes (NEI) de la antigua Union Sovietica, Turquia e Israel.
Abstract 18751: The Diverse Management and Prognosis of Supraventricular Tachycardia in Pregnant Women: Poor Prognosis for Pregnant Outcome in Patient With Non-psvt Pattern
Authors: Je-Wook Park, Taehoon Kim, Jae-Sun Uhm, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
Journal: Circulation (2016)

Introduction:  Supraventricular tachycardia (SVT) can be seen de novo or exacerbated by pregnancy, and can pose risks for both mother and fetus. But, the diverse management and fate of SVT in pregnant women were not well known.   Hypothesis:  We hypothesized that pregnant women with non-PSVT had poor pregnant outcomes.   Methods:  In 68 consecutive pregnant women with SVT, enrolled between January 2005 and April 2016. (mean age of 32±4 years), characteristics and pregnant outcomes were investigated during follow up period (median 272 days, 28-303 days). The primary endpoint was pregnant outcome as adverse pregnant events, which were composite of abortion, pre-term labor, late-term labor, fetal deformity at birth, and abnormal fetal birth weight ( 90 percentile of birth weight).   Results:  PSVT was the most frequent SVT (n=23, 33.8%) in this study. Non-PSVT were consisted of atrial tachycardia (n=12, 17.6%), atrial flutter (n=5, 7.4%), atrial fibrillation (n=12, 17.6%), and pre-excitation (n=16, 23.5%). SVT was first documented in 38 (56%) patients, and preexisting SVT was aggravated in 8 (12%) patients. While 18 out of 45 patients (40%) with non-PSVT had adverse pregnant events, patients with PSVT had 2 events (p = 0.07). No abortion events were occurred in patients with PSVT, compared with those with non-PSVT (p = 0.013). The Kaplan-Meier curve showed that patients with non-PSVT were associated with higher adverse pregnant events rather than those with PSVT (Log Rank, p = 0.008). Multivariate Cox regression analysis revealed that patients with non-PSVT underwent an independent poor prognosis for pregnant outcomes (HR 4.918, 95% CI 1.059-22.846, p = 0.042) when controlled for age, BMI, hemoglobin, and history of heart failure.   Conclusions:  Pregnant women with non-PSVT are associated with independent poor pregnant outcomes, compared with those with PSVT. Therefore, pregnant women with non-PSVT should be meticulously managed and treated before pregnancy if possible.
Feasibility, Process, and Outcomes of Cardiovascular Clinical Trial Data Sharing
Authors: Hawkins C. Gay, Abigail S. Baldridge, Mark D. Huffman
Journal: JAMA Cardiology (2017)

Data sharing is as an expanding initiative for enhancing trust in the clinical research enterprise.To evaluate the feasibility, process, and outcomes of a reproduction analysis of the THERMOCOOL SMARTTOUCH Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation (SMART-AF) trial using shared clinical trial data.A reproduction analysis of the SMART-AF trial was performed using the data sets, data dictionary, case report file, and statistical analysis plan from the original trial accessed through the Yale Open Data Access Project using the SAS Clinical Trials Data Transparency platform. SMART-AF was a multicenter, single-arm trial evaluating the effectiveness and safety of an irrigated, contact force-sensing catheter for ablation of drug refractory, symptomatic paroxysmal atrial fibrillation in 172 participants recruited from 21 sites between June 2011 and December 2011. Analysis of the data was conducted between December 2016 and April 2017.Effectiveness outcomes included freedom from atrial arrhythmias after ablation and proportion of participants without any arrhythmia recurrence over the 12 months of follow-up after a 3-month blanking period. Safety outcomes included major adverse device- or procedure-related events.The SMART AF trial participants' mean age was 58.7 (10.8) years, and 72% were men. The time from initial proposal submission to final analysis was 11 months. Freedom from atrial arrhythmias at 12 months postprocedure was similar compared with the primary study report (74.0%; 95% CI, 66.0-82.0 vs 76.4%; 95% CI, 68.7-84.1). The reproduction analysis success rate was higher than the primary study report (65.8%; 95% CI 56.5-74.2 vs 75.6%; 95% CI, 67.2-82.5). Adverse events were minimal and similar between the 2 analyses, but contact force range or regression models could not be reproduced.The feasibility of a reproduction analysis of the SMART-AF trial was demonstrated through an academic data-sharing platform. Data sharing can be facilitated through incentivizing collaboration, sharing statistical code, and creating more decentralized data sharing platforms with fewer restrictions to data access.
Primary Sclerosing Cholangitis Is Not Rare Among Blacks in a Multicenter North American Consortium
Authors: David S. Goldberg, Cynthia Levy, Kidist Yimam, Stuart C. Gordon, Lisa Forman, Elizabeth Verna, Lei Yu, Robert Rahimi, Kathleen Schwarz, Bertus Eksteen, Daniel Pratt, James L. Boyer, David Assis, Christopher Bowlus
Journal: Clinical Gastroenterology and Hepatology (2017)
Real-time differentiation of adenomatous and hyperplastic diminutive colorectal polyps during analysis of unaltered videos of standard colonoscopy using a deep learning model
Authors: Michael F Byrne, Nicolas Chapados, Florian Soudan, Clemens Oertel, Milagros Linares Pérez, Raymond Kelly, Nadeem Iqbal, Florent Chandelier, Douglas K Rex
Journal: Gut (2017)

Background In general, academic but not community endoscopists have demonstrated adequate endoscopic differentiation accuracy to make the ‘resect and discard’ paradigm for diminutive colorectal polyps workable. Computer analysis of video could potentially eliminate the obstacle of interobserver variability in endoscopic polyp interpretation and enable widespread acceptance of ‘resect and discard’. Study design and methods We developed an artificial intelligence (AI) model for real-time assessment of endoscopic video images of colorectal polyps. A deep convolutional neural network model was used. Only narrow band imaging video frames were used, split equally between relevant multiclasses. Unaltered videos from routine exams not specifically designed or adapted for AI classification were used to train and validate the model. The model was tested on a separate series of 125 videos of consecutively encountered diminutive polyps that were proven to be adenomas or hyperplastic polyps. Results The AI model works with a confidence mechanism and did not generate sufficient confidence to predict the histology of 19 polyps in the test set, representing 15% of the polyps. For the remaining 106 diminutive polyps, the accuracy of the model was 94% (95% CI 86% to 97%), the sensitivity for identification of adenomas was 98% (95% CI 92% to 100%), specificity was 83% (95% CI 67% to 93%), negative predictive value 97% and positive predictive value 90%. Conclusions An AI model trained on endoscopic video can differentiate diminutive adenomas from hyperplastic polyps with high accuracy. Additional study of this programme in a live patient clinical trial setting to address resect and discard is planned.
Antibacterial Inhibits Resistance
Authors: Rebecca Voelker
Journal: JAMA (2017)

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