tbuckley/cabot-search huggingface dataset:
Oral Contraceptive Use and the Risk of Endometrial Cancer
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ART<i>AIDS</i>AMERICA
Authors: Frank J. Palella
Journal: JAMA (2017)

Danger. Despair. Death. Shame. Fear. Hopelessness. Powerlessness. Isolation. Loss. Hope. These are some of the powerful themes apparent in the impressive and extensive visual arts exhibit ARTAIDSAMERICA, which closed a national tour in Chicago at the Alphawood Gallery in April 2017. Co-curated by Jonathan David Katz, from the University at Buffalo, and Rock Hushka, curator of Contemporary and Northwest Art at Tacoma Art Museum, the exhibit toured to critical acclaim—and some controversy—at the Tacoma Art Museum, Bronx Museum of the Arts, and the Bernard A. Zuckerman Museum of Art at Kennesaw State University in Georgia before its Chicago appearance.
P16.09 Pilocytic astrocytomas: comprehensive treatment approach
Authors: V. Smolanka, A. Smolanka
Journal: Neuro-Oncology (2017)

INTRODUCTION: Pilocytic astrocytomas (PAs) are WHO grade I neoplasms accounting for 5 to 6% of all gliomas, primarily affecting children and young adults with no gender predilection. Neoplasms such as pilocytic astrocytoma have excellent prognoses, even if resection has to be incomplete due to anatomic and other factors. Even though at least half of patients after subtotal (STR) or partial resection (PTR) will progress within 5 years, overall survival rates exceed 90%. PAs may remain quiescent after an incomplete resection suggests that tumors can exhibit decelerated growth kinetics over time and tumor cells may undergo senescence after an initial period of growth. Decisions regarding adjuvant radiation therapy are controversial after a STR or PTR. MATERIAL AND METHODS: A retrospective analysis of 10 consecutive surgical interventions on PAs that were treated at the Uzhhorod Regional Clinical Center of Neurosurgery and Neurology during the last 2.5 years (August 2014 to December 2016). The male-to-female ratio was 1:1. The mean age was 8 (from 3 to 17 years old). Localisation of tumors was as follows: brainstem - 3, optic pathways - 3, thalamus/hypothalamus - 2, cerebellum - 1, spinal cord - 1. In all patients the tumor cells show expression of GFAP and focal coexpression of Map2, all cases were without IDH1 mutation (variant R32H) and with preserved ATRX-expression.The mean Ki-67-labeling index for all the patients was 3 % RESULTS: According to the data, among the pilocytic astrocytoma prevail the tumors of the functionally eloquent areas (60%), with low mean proliferative index (3%). The degree of tumor removal: total/subtotal - 6 (60%), partial - 4 (40%) patients. There was no postoperative mortality. 3 (30%) received chemotherapy postoperatively and 7 had no adjuvant treatment. The results of treatment were assessed (median follow-up time - 10 month) according to Karnofsky scale: more than 60 points - 10 (100%) patients. CONCLUSIONS: In treating indolent tumors, the primary predictor of favourable oncological outcome is achieving maximum safe extent of the resection of the tumor. Significant long-term side effects make radiation difficult to justify as an adjuvant therapy in a patient population with excellent long-term survival. More prospective studies are needed to address the impact of modern radiation therapy technologies on patients outcome.
Ultrastructure of &lt;italic&gt;Mycoplasma orale&lt;/italic&gt; Isolated From Patients With Leukemia
Authors: Douglas R. Anderson, Michael F. Barile
Journal: JNCI Journal of the National Cancer Institute (1966)

Journal Article Ultrastructure of Mycoplasma orale Isolated From Patients With Leukemia Get access Douglas R. Anderson, Douglas R. Anderson Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael F. Barile Michael F. Barile Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 36, Issue 1, January 1966, Pages 161–167, https://doi.org/10.1093/jnci/36.1.161 Published: 01 January 1966 Article history Received: 05 May 1965 Published: 01 January 1966
Uncommon Manifestations of Common Malignancies
Authors: Hector Soto Parra, Paolo Andrea Zucali, Piergiuseppe Colombo, Luca Balzarini, Armando Santoro
Journal: Journal of Clinical Oncology (2004)

A 53-year-old man was diagnosed with malignant epithelial pleural mesothelioma after Tru-Cut biopsies of left parietal pleura and left supraclavicular lymph node. His clinical stage was III according to International Mesothelioma Interest Group classification. He received first-line chemotherapy with six courses of cisplatin and vinorelbine achieving partial remission. Nine months later, progressive disease was observed in mediastinal and bilateral supraclavicular lymph nodes; thus, radiotherapy (40 Gy) was performed on these sites. About 1 year later, the patient presented with contralateral lung disease and retroperitoneal masses. He received eight courses of multitarget antifolate therapy with disease stabilization. Two months later he underwent a chest and upper abdomen computed tomography scan that showed stable disease. However, he developed pain in the left buttock, and examination disclosed a fixed intramuscular mass. Magnetic resonance imaging showed a well-defined 4 2.5-cm mass in the left buttock, as well as another tumor mass in the left psoas muscle (Figs 1A and C, before, and B and D, after gadoliniumdiethylenetriamine pentaacetic acid injection; arrows, psoas and gluteus metastases). Musculoskeletal
P07.04 Local therapy with cytokine-induced killer cell for malignant gliomas
Authors: Y. Mou, K. Sai
Journal: Neuro-Oncology (2017)

Objective: To observe side-reaction and preliminary efficacy of local adoptive immunotherapy with cytokine-induced killer cells and to develop an aggressive treatment way to improve the prognosis of malignant gliomas. Methods: The tumor was resected totally or sub-totally under the neurosurgical microscope,when radiotherapy and chemotherapy have been finished for at least 6 weeks,if the patients were eligible, the CIK cells combined with 0.5 million IU interleukin-2 (IL-2) were infused via the ommaya reservoir-catheter system placed into the surgical resection cavity during operation. CIK cells were generated ex vivo by incubating peripheral blood mononuclear cells of the patient 7–10 days ago, and the number of CIK cells was 4 x 108,with the total volume is less than 4 ml, then, IL-2 alone was given via the ommaya reservoir on day 3 and 5 to complete one cycle of the therapy. This 7-day cycle was repeated at the next week. Each two-cycle constituted one full course of therapy. The treatment consisted of two 1-week cycles of therapy over 8–12 weeks period. Side-reaction were observed, such as headache,fever,and so on. Besides side-reaction, The efficacy was assessed by MRI scans retreated at 2- or 3-month interval and the survival of the patient summarized according to the follow-up also. Results: From September 2002 to May 2004, six malignant glioma patients were treated with local CIK cells therapy for ten courses, all the patients were followed up from 7 to 24 months by the end of March 2005. The Side-reaction included fever in two cases, headache in three cases and transient aphasia in one case and limb weakness in one patients, they were all controlled and the patient could tolerate. For the six patients in our study, with two out of 6 patients were still alive by the end of May 2016, survival time without recurrence was 13 and 12 years and the Karnofsky Permanence Scale were 100 and 70, respectively. Of the four patients with tumor recurrence, disease-free survival time was twenty months without other treatment after immunotherapy in one case, the rest three patients died. The efficacy was assessed: CR was in two cases;PR and ST were each in one case and PR in two cases. CONCLUSION: CIK cells can be administered intracavitary into CNS to treat primary malignant gliomas,the side-reaction was well tolerated; According to the eligibility criteria strictly, local cytokine-induced killer cell therapy for malignant gliomas appears to be safe and effective, it should be considered an option for patients with high-grade gliomas refractive to standard therapeutic approaches.
A new approach to transfect NF-κB decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method
Authors: Hiroyuki Yamaguchi, Yuji Ishida, Jun Hosomichi, Jun-ichi Suzuki, Risa Usumi-Fujita, Yasuhiro Shimizu, Sawa Kaneko, Takashi Ono
Journal: International Journal of Oral Science (2017)

The objective of this study is to investigate the effect of the ultrasound-microbubble technique in nuclear factor kappa B (NF-κB) decoy oligodeoxynucleotide (ODN) transfection in the gingival tissue in mice. The 6-FAM-labeled scrambled decoy ODN with microbubbles was applied to the periodontal tissue in 8-week-old male C57BL/6J mice by ultrasound radiation at low (LUM-Sc) and high (HUM-Sc) intensities to optimize the transfection condition of the ultrasound-microbubble method. Histological inspections were performed two hours after transfection to compare the expression with that in the sham-operated group without ultrasound radiation (A-Sc). Then, an NF-κB decoy was transfected into the periodontal tissue using the high-intensity ultrasound-microbubble (HUM-NF) technique to examine the anti-inflammatory effects of the decoy ODN. Western blot analysis was performed to investigate the expression of interleukin(IL)-1β, IL-6 and intercellular adhesion molecule-1 (ICAM-1) in the gingival tissues in the HUM-Sc, the HUM-NF and control groups. The fluorescence microscopy results showed that the fluorescent intensity in the periodontal tissues in the LUM-Sc and HUM-Sc groups was significantly higher than that in the A-Sc and the control groups. The fluorescent intensity in the HUM-Sc group, especially in the gingival connective tissue, was the highest of all groups. Western blot analysis indicated that the protein expression levels of IL-1β, IL-6 and ICAM-1 in the HUM-NF group were significantly lower than those in the HUM-Sc and the control groups. These findings suggest that the high-intensity ultrasound-microbubble technique is an effective tool for decoy transfection into the periodontal tissue.
Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study
Authors: Daniel N Cagney, Allison M Martin, Paul J Catalano, Amanda J Redig, Nancy U Lin, Eudocia Q Lee, Patrick Y Wen, Ian F Dunn, Wenya Linda Bi, Stephanie E Weiss, Daphne A Haas-Kogan, Brian M Alexander, Ayal A Aizer
Journal: Neuro-Oncology (2017)

Brain metastases are associated with significant morbidity and mortality. Population-level data describing the incidence and prognosis of patients with brain metastases are lacking. The aim of this study was to characterize the incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy using recently released data from the Surveillance, Epidemiology, and End Results (SEER) program.
P08.16 ATF3 reduces migration capacity by regulation of matrix metalloproteinases in glioblastoma in vitro
Authors: J. Guenzle, J. Goeldner, A. Weyerbrock
Journal: Neuro-Oncology (2017)

Objective: Glioblastoma is associated with poor survival and a high recurrence rate in patients due to the inevitable uncontrolled infiltrative tumor growth. The elucidation of the molecular mechanisms may offer opportunities to prevent relapses. In this study we investigated the role of the activating transcription factor 3 (ATF3) in the context of experimental nitric oxide donor (NO) treatment with JS-K (O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin- 1-yl]diazen-1-ium-1,2-diolate) on migration of GBM cells in vitro. Methods: RNA microarray was performed to identify ATF3 as one of the genes upregulated by experimental NO therapy in U87 glioma cells. To elucidate its role in tumor growth and treatment response of malignant gliomas, ATF3 was overexpressed by lentiviral transduction and expression of target genes STAT3 and NFκB was investigated by qRT-PCR, Western Blot and immunocytochemistry. The underlying molecular mechanisms of migration capacity and proliferation were studied by Western Blot, zymography, immunostaining and PCR while migration was assessed by wound closure and invasion assay. Results: RNA microarray revealed that gene expression of ATF3 is 15-fold upregulated after exposure to 15 µM JS-K for 48 h. We demonstrate that ATF3 is directly involved in the regulation of matrix metalloproteinase expression and activation. MMP2, 7 and 9 were downregulated and MMP2 activity was reduced by overexpression of ATF3. While stat3 was 2.5-fold upregulated in cells overexpressing ATF3, STAT3 was no longer phosphorylated. Even if the expression of nfκb is not affected by ATF3, NFκB accumulated in the cytoplasm and did not translocate by TNFα stimulation. Cells overexpressing ATF3 migrated 40% slower into the gap (p=0.02) and reduced invasive capability to 30% (p=0.00004). The proliferation rate was 2-fold reduced by ATF3 (p=0.003) after 72 h whereas the influence of NO on viability did not change. Conclusions: Overexpression of ATF3 leads to a significantly reduced migration and invasion capacity by induction of tissue inhibitors of matrix metalloproteinases. ATF3 is directly involved in expression and activation of MMPs as well as the oncogenic regulators STAT3 and NFκB. Our study highlights for the first time ATF3 as a potential novel therapeutic target and can therefore be important for specific anticancer therapy to overcome the high treatment resistance of glioblastoma.
Mandatory reporting of fitness to drive doesn’t work
Authors: Desmond O'Neill
Journal: BMJ (2017)

Sokol discusses the mandatory reporting of patients unfit to drive.1 I am sympathetic to the victims of road crashes, but practice must be evidence based. Mandatory reporting of medical conditions relevant to driving does not work for epilepsy,2 dementia,3 or obstructive sleep apnoea,4 among others. Notably, epilepsy …
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum
Authors: James E East, Wendy S Atkin, Adrian C Bateman, Susan K Clark, Sunil Dolwani, Shara N Ket, Simon J Leedham, Perminder S Phull, Matt D Rutter, Neil A Shepherd, Ian Tomlinson, Colin J Rees
Journal: Gut (2017)

Serrated polyps have been recognised in the last decade as important premalignant lesions accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical need for guidance on how to manage these lesions; however, the evidence base is limited. A working group was commission by the British Society of Gastroenterology (BSG) Endoscopy section to review the available evidence and develop a position statement to provide clinical guidance until the evidence becomes available to support a formal guideline. The scope of the position statement was wide-ranging and included: evidence that serrated lesions have premalignant potential; detection and resection of serrated lesions; surveillance strategies after detection of serrated lesions; special situations—serrated polyposis syndrome (including surgery) and serrated lesions in colitis; education, audit and benchmarks and research questions. Statements on these issues were proposed where the evidence was deemed sufficient, and re-evaluated modified via a Delphi process until &gt;80% agreement was reached. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tool was used to assess the strength of evidence and strength of recommendation for finalised statements. Key recommendation : we suggest that until further evidence on the efficacy or otherwise of surveillance are published, patients with sessile serrated lesions (SSLs) that appear associated with a higher risk of future neoplasia or colorectal cancer (SSLs ≥10 mm or serrated lesions harbouring dysplasia including traditional serrated adenomas) should be offered a one-off colonoscopic surveillance examination at 3 years ( weak recommendation, low quality evidence, 90% agreement ).
P15.01 Clinical utility of FDG-PET/CT for diagnosis and staging in patients with primary central nervous system lymphoma: prospective single arm study
Authors: T. Gupta, M. Gupta, V. Rangarajan, N. Purandare, G. Sastri, H. Menon, A. Moiyadi, P. Shetty, S. Epari, R. Jalali
Journal: Neuro-Oncology (2017)
P17.07 The impact of postoperative radiation therapy on patterns of failure and survival improvement in patients with intracranial hemangiopericytoma
Authors: J. Kim
Journal: Neuro-Oncology (2017)

Because of the rarity of intracranial hemangiopericytomas (HPCs), the role of postoperative radiation therapy (PORT) in the management of HPC remains unclear. This study therefore analyzed the effects of PORT on patterns of failure and survival improvement in patients with HPC. Fifty-two patients surgically treated for intracranial HPC at our institution between 1992 and 2013 were retrospectively analyzed. Patterns of failure were subdivided into local recurrence, regional metastasis, and distant metastasis. Multivariate Cox proportional hazards models were used to assess factors prognostic of treatment failure and survival, and a time-dependent Cox proportional hazards models were used to investigate the correlations between patterns of failure and death. Of the 52 patients, 45 (87 %) underwent gross total resection, and 39 (75 %) received PORT. PORT significantly lengthened local control (LC) and overall survival (OS), by 14 and 13 months, respectively, independent of the extent of resection. Patients who did and did not receive PORT had 5 year LC rates of 97 and 44 %, respectively (HR .05, P = .002); and 10 year OS rates of 83 and 25 %, respectively (hazard ratio (HR) .20, P = .008). PORT, however, did not show preventive effects on regional and distant metastases. The main patterns of failure were local recurrence in patients who did not receive PORT and distant metastasis in those who received PORT. Regional metastasis was a main immediate cause of death (P\.001), and tended to occur more frequently and earlier in patients not receiving PORT.
Outstanding Early-Career Investigator Award Finalists
Authors: Shahrzad Abbasi, Tiejuan Mi, Mei Li, Peter Razeghi, Rodney Kellems, Yang Xia
Journal: Circulation Research (2005)

Ca 2ϩ -dependent and Ca 2ϩ -independent signaling pathways are associated with cardiac hypertrophy.How these two pathways crosstalk with each other resulting in cardiac hypertrophy is poorly understood.To address this issue we designed a transfection bioassay to monitor NFAT activation in cultured rat neonatal cardiomyocytes.We determined that active MEKK3 was capable of stimulating calcineurin(Cn)/NFAT signaling in cardiac myocytes.Overexpression of active MEKK3 in cardiac myocytes and mouse hearts resulted in Cn/NFAT activation and reprogramming cardiac gene expression.In contrast, small interference RNA directed against MEKK3 and a dominant negative form of MEKK3 caused the loss of NFAT activation in response to angiotensin II (Ang II) in cardiac myocytes.Likewise, MEKK3-deficient mouse embryo fibroblasts failed to activate Cn/NFAT in response to Ang II, a potent NFAT activator.Conversely, restoring MEKK3 to the MEKK3-deficient cells restored Ang II-mediated Cn/NFAT activation.Thus, MEKK3 is sufficient and essential for Cn activation.Next we determined that MEK5 and BMK1 function downstream of MEKK3 to induce NFAT activation.Physical interaction assays showed that activated MEKK3/MEK5/BMK1 formed complex with MCIP1, a Cn interacting protein, resulting in its phosphorylation.In vivo labeling experiments and immunoprecipitation pulldown assays revealed that phospho-MCIP1 dissociated from Cn catalytic subunit and interacted with an unknown 31 KD protein.Sequence analysis of MCIP1 revealed a serine-proline (SP) repeat domain with the potential to bind with a 31 kDa protein termed 14 -3-3, a multifunctional phosphopeptide binding protein.Subsequent coimmunoprecipitation experiments demonstrated that phosphorylation of MCIP1 resulted in reduced affinity for Cn and increased affinity for 14 -3-3, thereby displacing phospho-NFAT from it docking site on 14 -3-3.The displaced phospho-NFAT interacted with Cn, where it was dephosphorylated allowing entry in the nucleus to contribute to the hypertrophic transcriptional response.Thus, our findings reveal a previously unrecognized novel essential regulatory role of MAP kinase signaling in Cn activation.