SAT0690 The association between sarcoidosis and ischaemic heart disease – a big data analysis
Authors: D. Katz, S. Tiosano, D. Comaneshter, A.D. Cohen, H. Amital
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Sarcoidosis is an inflammatory disease characterised by the hallmark sign of non-caseating granulomas<sup>1,2</sup>. In the past decade a consensus has formed regarding the pivotal role of inflammation in atherosclerosis<sup>3</sup>. Since this discovery the association between chronic inflammatory states and ischaemic heart disease was confirmed in several rheumatic diseases<sup>4</sup>. Therefore, the constant state of inflammation to which sarcoidosis patients are exposed might pose as a risk factor for ischaemic heart disease. <h3>Objectives</h3> The aim of this study is to assess the relation between sarcoidosis and Ischaemic heart disease and its prognostic significance. <h3>Methods</h3> Based on data from Clalit Health Services (CHS), Israel's largest health maintenance organisation, the medical records of 3993 sarcoidosis patients and 19 856 controls were acquired. Controls were matched to sarcoidosis patients according to age and sex. Chi-square and student t-tests were used in order to compare variables distribution in the cohort. Variables associated with ischaemic heart disease were assessed by logistic regression model. Log-rank test was performed for survival analysis, while Cox proportional hazards method was utilised to evaluate variables related to increased risk of all-cause mortality. <h3>Results</h3> Matched by sex and age – both sarcoidosis group and the control group were composed from 63% females with mean age being 56 years. Compared to the control group, sarcoidosis patients had a higher proportion of ischaemic heart disease, presenting with 856 (21.4%) cases whereas the control group had only 2999 cases (15.1%, p&lt;0.001). The association between sarcoidosis and ischaemic heart disease was demonstrated by a multivariate analysis, (adjusted OR 1.503, 95% CI 1.361–1.660). A 15 year follow up revealed increased mortality among sarcoidosis patients – as 710 (17.8%) of sarcoidosis patients had passed away while 2121 (10.7%) deaths were reported in the control group (p&lt;0.001). In a multivariate model, sarcoidosis patients were found to be in increased risk for all-cause mortality compared to the control group (adjusted HR 1.95, 95% CI 1.75–2.14). <h3>Conclusions</h3> Sarcoidosis is associated with an increased risk for ischaemic heart disease and all-cause mortality. Patients with co-morbidity of sarcoidosis and ischaemic heart disease should be treated accordingly. <h3>References</h3> [1] Markevitz, N, Epstein Shochet G, Levi Y, Israeli-Shani L, Shitrit D. Sarcoidosis in Israel: Clinical Outcome Status, Organ Involvement, and Long-Term Follow-Up. Lung2017;195;419–424. [2] Valeyre D, et al. Sarcoidosis. Lancet (London, England)2014;383;1155–67. [3] Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation2004;109:II2–10. [4] Shoenfeld Y, et al. Accelerated Atherosclerosis in Autoimmune Rheumatic Diseases. Circulation2005;112:3337–3347. <h3>Disclosure of Interest</h3> None declared