tbuckley/cabot-search huggingface dataset:
The quantitative link of lung clearance index to bronchial segments affected by bronchiectasis
Authors: Sylvia Verbanck, Gregory G King, Wenxiao Zhou, Anne Miller, Cindy Thamrin, Daniel Schuermans, Bart Ilsen, Caroline W Ernst, Johan de Mey, Walter Vincken, Eef Vanderhelst
Journal: Thorax (2017)

In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease.
SAT0388 Analysis of the musculoskeletal manifestations in inflammatory bowel disease patients and its relationship with biological treatment
Authors: S Mainero Mendoza, CM Feced Olmos, L Gonzalez Puig, J Ivorra Cortes, I Martínez Cordellat, C Nájera Herranz, R Negueroles Albuixech, JE Oller Rodriguez, FM Ortiz-Sanjuan, E Vicens Bernabeu, E Grau Garcia, E Sánchez Labrador, K Arévalo Ruales, JJ Fragio Gil, R Mazarío González, C Alcañiz Escandell, I Cánovas Olmos, I Chalmeta Verdejo, V Fornés Ferrer, JA Román Ivorra
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Crohn9s disease (CD) and ulcerative colitis (UC) are the main entities of inflammatory bowel disease (IBD). Both present extraintestinal manifestations that do not always depend on the IBD activity. The most common manifestations involve the musculoskeletal system and they are included in the seronegative spondiloarthritis group. If there is active or known IBD, treatment of this is priority because it usually improves joint disease. However, joint disease can also have an independent course of the intestinal manifestations as in patients with IBD and ankylosing spondylitis (AS). <h3>Objectives</h3> To analyze the prevalence of extraintestinal manifestations in IBD patients and treatment provided. <h3>Methods</h3> Retrospective observational analysis of IBD patients that have been remitted to the rheumatology department of HUP La Fe with musculoskeletal manifestations. Demographic, clinical and treatment data of patient were collected. Biostatistical analysis with R (3.3.2.) was performed. <h3>Results</h3> We recruited 183 patients diagnosed with IBD (57.4% women), 117 with CD and 66 with UC, with a mean age at diagnosis of 37.03±14.02 years old. 29 of them have axial affection and 51 peripheral affection, and simultaneously in 22 cases. We observed no statistical differences in axial or peripheral affection according to the IBD diagnosis. 79 cases were on biological therapy, and these treatments were conducted by Rheumatology in the 44% of cases and by Digestive Department in the 66% of cases. We observed that patients with axial affection present higher probability that the treatment has been conducted by Rheumatology (P=0.007), and broken down axial affections AS diagnosis had the most probability to be conducted by Rheumatology (n=36 P=0.0102). Related to peripheral manifestations, uveitis diagnosis had the most probability to be conducted by Rheumatology (n=14 P=0.0337). <h3>Conclusions</h3> In our patient series with IBD and musculoskeletal manifestations, the most common were peripheral affection. Among patients with IBD and axial and/or peripheral manifestation, 44% were conducted by Rheumatology, and are cases with axial predominance, where IBD treatment does not improve musculoskeletal disease and a primary spondyloarthritis treatment is needed. <h3>Disclosure of Interest</h3> None declared
A Violaceous, Photodistributed Cutaneous Eruption and Leg Ulcer in a Woman With Essential Thrombocytosis
Authors: Jody Platto, Christina E. Alexander, Drew J. B. Kurtzman
Journal: JAMA Dermatology (2017)

A 69-year-old woman presented for the evaluation of a progressive, asymptomatic cutaneous eruption on her hands and forearms, as well as an enlarging, painful ulcer on her left leg that developed 6 months earlier; her medical history was notable for essential thrombocytosis. What is your diagnosis?
ケモカイン受容体CXCR4とクロマチンリモデリング酵素,NCOA3のポリプレックス仲介阻害は膵臓癌の進行および転移を阻害する【Powered by NICT】
Authors: Wang Yan, Kumar Sushil, Rachagani Satyanarayana, R Sajja Balasrinivasa, Xie Ying, Hang Yu, Jain Maneesh, Li Jing, D Boska Michael, K Batra Surinder, Oupicky David
Journal: Biomaterials (2016)
免疫調節ナノ粒子はLeishmania(Viannia)panamensisマウスモデルにおける疾患を改善する【Powered by NICT】
Authors: L Siefert Alyssa, Ehrlich Allison, Corral Maria Jesus, Goldsmith-Pestana Karen, McMahon-Pratt Diane, M Fahmy Tarek
Journal: Biomaterials (2016)
Natural protective immunity against grass pollen allergy is maintained by a diverse spectrum of response types
Authors: Almedina Kurtaj, Christoph Hillebrand, Gerda Fichtinger, Eva Hattinger, Melanie Lietzenmayer, Yoan Machado, Sandra Scheiblhofer, Angelika Stoecklinger, Theresa Thalhamer, Susanne Suessner, Martin Danzer, Sabine Keplinger, Johannes Weinberger, Susanne Schaller, Stephan Winkler, Christian Gabriel, Josef Thalhamer, Richard Weiss
Journal: Journal of Allergy and Clinical Immunology (2017)
Targeting p53 mutant ovarian cancer: Phase I results of the WEE1 inhibitor MK-1775 with carboplatin plus paclitaxel in patients (pts) with platinum-sensitive, p53-mutant ovarian cancer (OC).
Authors: Irene Brana, Kathleen N. Moore, Ronnie Shapira-Frommer, Stephen Welch, Ying-Ming Jou, Michelle Marinucci, Tomoko Freshwater, Shelonitda Rose, Amit M. Oza
Journal: Journal of Clinical Oncology (2013)

5518 Background: MK-1775 is a highly selective, investigational oral tyrosine kinase inhibitor of WEE1, which regulates G2 cell cycle checkpoint. Functional p53 mutation impairs G1 checkpoint; hence, targeting G2 checkpoint with MK-1775 in p53 mutants should induce synthetic lethality. Methods: Pts with platinum-sensitive disease-recurrent OC who had measurable disease (RECIST 1.1) with loss of function (LOF) p53 mutations by Roche AmpliChip were eligible. All pts received MK-1775 225mg twice daily (BID) D1-D3 (5 doses) plus carboplatin AUC5 + paclitaxel 175mg/m 2 every 21 days (CP) for 6 cycles. The objective for the phase I run-in portion of the study was to determine the recommended phase II dose based on safety data. A Toxicity Probability Interval method [Ji et al, Clin Trials 2010; 7(6):653-63] would determine if additional lower doses should be explored. A randomized phase II portion, assessing the efficacy of the combination vs placebo, would start if ≥5 radiological responses and &lt;5 dose-limiting toxicities (DLTs) were observed among the first 13 pts. Results: Of 76 pts screened (26 wt, 43 mutant [24 nonfunctional], 7 undetermined), 19 women had LOF p53 mutations and were eligible. Fifteen consented and were enrolled in the Phase I: median age was 57 (range 38-77); ECOG 0:1 ratio 9:6 pts. Three DLTs were observed: G3 febrile neutropenia, G4 neutropenia, and G4 thrombocytopenia. Diarrhea (84.6%), nausea (76.9%), and fatigue (76.9%) were the most common adverse events (AEs). Seven of 13 pts completed treatment (2 ongoing). Three pts discontinued due to AEs and 3 patients withdrew consent prior to completing treatment. Of 14 evaluable pts by RECIST 1.1 there were 11 partial responses (PRs; 6 confirmed, 5 unconfirmed) and 3 had stable disease; 7 pts were evaluable by CA125 with 3 complete responses and 4 PRs. MK-1775 PK results were similar to those reported for monotherapy studies. Conclusions: The combination of MK-1775 225mg BID x 5 doses with CP is well tolerated, with a preliminary radiological response rate of 78.6%, and has met the safety and efficacy bar for randomized phase II assessment in part 2 of the study. Clinical trial information: NCT01357161.
Non-base-contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding
Authors: Hamed S. Najafabadi, Michael Garton, Matthew T. Weirauch, Sanie Mnaimneh, Ally Yang, Philip M. Kim, Timothy R. Hughes
Journal: Genome biology (2017)

The C2H2 zinc finger (C2H2-ZF) is the most numerous protein domain in many metazoans, but is not as frequent or diverse in other eukaryotes. The biochemical and evolutionary mechanisms that underlie the diversity of this DNA-binding domain exclusively in metazoans are, however, mostly unknown. Here, we show that the C2H2-ZF expansion in metazoans is facilitated by contribution of non-base-contacting residues to DNA binding energy, allowing base-contacting specificity residues to mutate without catastrophic loss of DNA binding. In contrast, C2H2-ZF DNA binding in fungi, plants, and other lineages is constrained by reliance on base-contacting residues for DNA-binding functionality. Reconstructions indicate that virtually every DNA triplet was recognized by at least one C2H2-ZF domain in the common progenitor of placental mammals, but that extant C2H2-ZF domains typically bind different sequences from these ancestral domains, with changes facilitated by non-base-contacting residues. Our results suggest that the evolution of C2H2-ZFs in metazoans was expedited by the interaction of non-base-contacting residues with the DNA backbone. We term this phenomenon "kaleidoscopic evolution," to reflect the diversity of both binding motifs and binding motif transitions and the facilitation of their diversification.
Comparison of paclitaxel and docetaxel as single agents or in combination with bevacizumab in the 4T1 metastatic breast tumor line
Authors: Mario Sepulveda, Scott Kelley, Lionel Gomez, Jennifer Marty, Michael J. Wick, Wesley Lowell, Chris H. Takimoto
Journal: Cancer Research (2006)

959  Paclitaxel (Taxol) and docetaxel (Taxotere) are anticancer agents in a class of compounds called taxanes which act by stabilizing microtubules and inducing apoptosis. Bevacizumab (Avastin) is a humanized monoclonal antibody which disrupts tumor vascularization by blocking signaling through the vascular endothelial growth factor (VEGF) receptor. Some benefit has been reported by combining bevacizumab with standard chemotherapies in preclinical and clinical studies. In addition, experiments comparing single agent activity of paclitaxel to docetaxel have produced conflicting results. To examine potential additive activity of bevacizumab with taxanes and to further compare efficacy of these compounds, we examined single agent and combination antitumor activity in the 4T1 orthotopic metastatic breast cancer model in immunocompetent mice. Paclitaxel was dosed at 15 mg/kg once daily for five treatments (QDx5) while docetaxel was administered every other day for three treatments at 12.5 mg/kg (QODx3); bevacizumab was dosed at 10 mg/kg every three days for five treatments (Q3Dx5). Significant endpoints included tumor growth inhibition (TGI), metastasis, tumor regression, and weight loss. Tested alone, paclitaxel produced only moderate TGI in this model (21%), which was not increased by bevacizumab co-treatment. However, single agent docetaxel treatment resulted in significant tumor growth inhibition (p
腫瘍イメージングと深部組織治療のための二重標的化発光性金ナノクラスタ【Powered by NICT】
Authors: Chen Dan, Li Bowen, Cai Songhua, Wang Peng, Peng Shuwen, Sheng Yuanzhi, He Yuanyuan, Gu Yueqing, Chen Haiyan
Journal: Biomaterials (2016)
Abstract 133: A Systems Genetics Approach to Identify Genetic Pathways and Key Drivers of Isoproterenol-induced Cardiac Hypertrophy and Cardiomyopathy in Mice
Authors: Christoph D Rau, Milagros Romay, Jessica Wang, Aldons J Lusis, Yibin Wang
Journal: Circulation Research (2016)

Heart Failure (HF) is a complex disease involving numerous environmental and genetic factors. We previously reported a genetic analysis of HF traits in a population of inbred mouse strains treated with isoproterenol, a β-adrenergic agonist used to mimic catecholamine-driven cardiac hypertrophy. We now present a systems genetics analysis in which we have used left ventricular transcript levels from these mice to perform co-expression network modeling. We constructed gene networks composed of 8,126 genes and 20 modules using the wMICA algorithm. In the wMICA network generated from treated hearts, we identified a module with significant correlations to several HF-related phenotypic traits. Further analysis of this module showed significant over-representation of genes known to contribute to the development of HF. Using the causal modeling algorithm NEO, we identified the gene Adamts2 as a putative master regulator of the module. We then validated the role of this gene through siRNA-mediated knockdown in neonatal rat ventricular myocytes (NRVM). Consistent with our model, Adamts2 silencing was able to regulate the expression of the genes residing within the module as well as impairing isoproterenol-induced cell size changes . Our results provide a view of higher order interactions in heart failure with potential to facilitate diagnostic and therapeutic approaches.
Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis
Authors: Yibing Yang, Xinya Gao, Maolei Zhang, Sheng Yan, Chengjun Sun, Feizhe Xiao, Nunu Huang, Xuesong Yang, Kun Zhao, Huangkai Zhou, Suyun Huang, Bo Xie, Nu Zhang
Journal: JNCI Journal of the National Cancer Institute (2017)

Circular RNAs (circRNAs) are RNA transcripts that are widespread in the eukaryotic genome. Recent evidence indicates that circRNAs play important roles in tissue development, gene regulation, and carcinogenesis. However, whether circRNAs encode functional proteins remains elusive, although translation of several circRNAs was recently reported. CircRNA deep sequencing was performed by using 10 pathologically diagnosed glioblastoma samples and their paired adjacent normal brain tissues. Northern blotting, Sanger sequencing, antibody, and liquid chromatograph Tandem Mass Spectrometer were used to confirm the existence of circ-FBXW7 and its encoded protein in in two cell lines. Lentivirus-transfected stable U251 and U373 cells were used to assess the biological functions of the novel protein in vitro and in vivo (five mice per group). Clinical implications of circ-FBXW7 were assessed in 38 pathologically diagnosed glioblastoma samples and their paired periphery normal brain tissues by using quantitative polymerase chain reaction (two-sided log-rank test). Circ-FBXW7 is abundantly expressed in the normal human brain (reads per kilobase per million mapped reads [RPKM] = 9.31). The spanning junction open reading frame in circ-FBXW7 driven by internal ribosome entry site encodes a novel 21-kDa protein, which we termed FBXW7-185aa. Upregulation of FBXW7-185aa in cancer cells inhibited proliferation and cell cycle acceleration, while knockdown of FBXW7-185aa promoted malignant phenotypes in vitro and in vivo. FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization. Moreover, circ-FBXW7 and FBXW7-185aa levels were reduced in glioblastoma clinical samples compared with their paired tumor-adjacent tissues (P < .001). Circ-FBXW7 expression positively associated with glioblastoma patient overall survival (P = .03). Endogenous circRNA encodes a functional protein in human cells, and circ-FBXW7 and FBXW7-185aa have potential prognostic implications in brain cancer.
メチル化:メチル化ハプロタイプブロックの同定は,不均一な組織試料のデコンボリューションや血漿DNAからの腫瘍組織起源のマッピングに役立つ
Authors: Guo Shicheng, Diep Dinh, Plongthongkum Nongluk, Fung Ho‐Lim, Zhang Kun, Zhang Kang
Journal: Nature Genetics (2017)
Neighborhood-Level Disparities in Resuscitation and the Potential of Connected Health
Authors: Raina M. Merchant, Peter W. Groeneveld
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Effect of Telemedicine Education and Telemonitoring on Continuous Positive Airway Pressure Adherence. The Tele-OSA Randomized Trial
Authors: Dennis Hwang, Jeremiah W. Chang, Adam V. Benjafield, Maureen E. Crocker, Colleen Kelly, Kendra A. Becker, Joseph B. Kim, Rosa R. Woodrum, Joanne Liang, Stephen F. Derose
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Rationale: Automated telemedicine interventions could potentially improve adherence to continuous positive airway pressure (CPAP) therapy.Objectives: Examining the effects of telemedicine-delivered obstructive sleep apnea (OSA) education and CPAP telemonitoring with automated patient feedback messaging on CPAP adherence.Methods: This four-arm, randomized, factorial design clinical trial enrolled 1,455 patients (51.0% women; age, 49.1 ± 12.5 yr [mean ± SD]) referred for suspected OSA. Nine hundred and fifty-six underwent home sleep apnea testing, and 556 were prescribed CPAP. Two telemedicine interventions were implemented: 1) web-based OSA education (Tel-Ed) and 2) CPAP telemonitoring with automated patient feedback (Tel-TM). Patients were randomized to 1) usual care, 2) Tel-Ed added, 3) Tel-TM added, or 4) Tel-Ed and Tel-TM added (Tel-both).Measurements and Main Results: The primary endpoint was 90-day CPAP usage. Secondary endpoints included attendance to OSA evaluation, and change in Epworth Sleepiness Scale score. CPAP average daily use at 90 days was 3.8 ± 2.5, 4.0 ± 2.4, 4.4 ± 2.2, and 4.8 ± 2.3 hours in usual care, Tel-Ed, Tel-TM, and Tel-both groups. Usage was significantly higher in the Tel-TM and Tel-both groups versus usual care (P = 0.0002 for both) but not for Tel-Ed (P = 0.10). Medicare adherence rates were 53.5, 61.0, 65.6, and 73.2% in usual care, Tel-Ed, Tel-TM, and Tel-both groups (Tel-both vs. usual care, P = 0.001; Tel-TM vs. usual care, P = 0.003; Tel-Ed vs. usual care, P = 0.07), respectively. Telemedicine education improved clinic attendance compared with no telemedicine education (show rate, 68.5 vs. 62.7%; P = 0.02).Conclusions: The use of CPAP telemonitoring with automated feedback messaging improved 90-day adherence in patients with OSA. Telemedicine-based education did not significantly improve CPAP adherence but did increase clinic attendance for OSA evaluation.Clinical trial registered with www.clinicaltrials.gov (NCT02279901).
Abstract P2-01-01: Prospective study of the need for axillary dissection and outcomes in Z11 eligible patients accounting for the use of nodal RT
Authors: M Morrow, A Mamtani, S Patil, A Barrio, ML Pilewskie, HS Cody, M Gemignani, LM Sclafani, AY Ho, KJ Van Zee
Journal: Cancer Research (2017)

Abstract This abstract was withdrawn by the authors.
iRGD修飾インドシアニングリーンナノ粒子による腫瘍に対する分子造影ガイド高熱/光線力学治療iRGD修飾インドシアニングリーンナノ粒子による腫瘍に対する分子造影ガイド高熱/光線力学治療
Authors: Yan Fei, Wu Hao, Liu Hongmei, Deng Zhiting, Liu Hong, Duan Wanlu, Liu Xin, Zheng Hairong
Journal: Journal of Controlled Release (2016)
ヒト多能性幹細胞の超高感度検出のための新しい表面増強Raman散乱に基づく分析【Powered by NICT】
Authors: Han Jingjia, Qian Ximei, Wu Qingling, Jha Rajneesh, Duan Jinshuai, Yang Zhou, O Maher Kevin, Nie Shuming, Xu Chunhui
Journal: Biomaterials (2016)
ドキソルビシンの治療効果を向上させるためのミトコンドリアと核二重標的不均一ヒドロキシアパタイトナノ粒子【Powered by NICT】
Authors: Xiong Hui, Du Shi, Ni Jiang, Zhou Jianping, Yao Jing
Journal: Biomaterials (2016)
Vitamin D Supplementation and Cardiovascular Disease Risk
Authors: Armin Zittermann, Stefan Pilz
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation
Authors: Anand Padmanabhan, Curtis G Jones, Shannon M Pechauer, Barbara J. Bryant, Jack B. Alperin, Mehraboon S. Irani, Binod Dhakal, Brian R Curtis, Daniel W. Bougie, Mia J Sullivan, Renren Wen, Demin Wang, Richard H. Aster
Journal: Blood (2016)
Thrombotic Thrombocytopenic Purpura Predominance in the Southern United States; Trends in Regional and Seasonal Variation and Mortality of TTP Utilizing the National Inpatient Sample Database Between 1999 and 2013
Authors: Jordan Carter, William Lee, Stuthi Perimbeti, Ya Yu Liang, Rachel Nathan, Doris Rivas, Luiz Marconcini, Parshva Patel, Kristine Ward, Michael Styler, Maneesh Jain
Journal: Blood (2016)
The phasing out of mental hospitals in the United States
Authors: M Greenblatt, E Glazier
Journal: American Journal of Psychiatry (1975)

The authors view the current wave of closing state mental hospitals against the background of trends in mental health services during the past 20 years. Although a small number of hospitals has been totally closed, the overall number of institutions has remained stable due to the opening of new hospitals, and many states will be forced to consider phasing out additional hospitals in the immediate future. The closing of hospitals is a social phenomenon that involves the lives and welfare of patients, personnel, families, and the community and poses a substantial political and logistical challenge. The authors make a few suggestions for those who are contemplating closing hospitals in the future.
The empress of subterfuge: cancer of the fallopian tube presenting with malapropism
Authors: Lucy Gilbert, Timothée Revil, Charles Meunier, Kris Jardon, Xing Zeng, Claudia Martins, Jocelyne Arseneau, Lili Fu, Krystle North, Alicia Schiavi, Eric Ehrensperger, Giovanni Artho, Todd Lee, David Morris, Jiannis Ragoussis
Journal: The Lancet (2017)