tbuckley/cabot-search huggingface dataset:
ESTIMATING DIFFICULTY OF ENDOSCOPIC RESECTION WITH SMSA POLYP COMPLEXITY CLASSIFICATION SYSTEM
Authors: P Puz, H Ivekovic, I Tiric, Z Trescec, M Narancic, B Mariani, N Rustemovic
Journal: Endoscopy (2018)

SMSA classification system consists of four factors (size, morphology, site, access) from which it identifies four different levels of polyp complexity (L1-L4).
Spy-Glass: Estudio restrospectivo sobre sus indicaciones y rendimiento diagnóstico y terapéutico en un hospital terciario
Authors: K Cárdenas Jaén, JR Aparicio, F Ruiz, L Compañy, JF Martínez, JA Casellas
Journal: Endoscopy (2017)

El nuevo sistema Spy-Glass DS, permite la realización de colangioscopia/pancreatoscopia con visión directa digital, y efectuar medidas diagnósticas y terapéuticas con un solo operador.
Lesiones colorrectales con displasia de bajo grado resecadas con disección: Valoración de la concordancia con la guía de práctica clínica de la SEED
Authors: F Ramos-Zabala, L Moreno-Almazán, M García-Mayor, A Alzina-Pérez, J Vásquez-Guerrero, FJ Pérez-Rodríguez, J Rodríguez-Pascual, E Gento-Peña, C Gil-Páez, S Blasco-Algora
Journal: Endoscopy (2017)

La disección submucosa endoscópica colorrectal (DSE-CR) es una técnica compleja indicada en lesiones de gran tamaño en las que la resección en bloque mediante mucosectomía es difícil. Cuando el resultado histológico de la pieza resecada es de displasia de bajo grado (DBG) es posible pensar que el tratamiento con DSE pueda ser excesivo.
FACTORS ASSOCIATED WITH OCCURRENCE OF METACHRONOUS TUMOR AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER
Authors: EY Kim, EJ Kim, JT Jung, JG Kwon
Journal: Endoscopy (2018)

Endoscopic submucosal dissection (ESD) has become accepted as a curative treatment for early gastric cancer (EGC). However, occurrence of metachronous gastric tumor (MGT) after ESD has become one of the major concerns. The aim of this study is to investigate the factors associated with occurrence of MGT after ESD for EGC.
Receptor mediated transcytosis in biological barrier: The influence of receptor character and their ligand density on the transmembrane pathway of active-targeting nanocarriers
Authors: Xiaoning Song, Rui Li, Hailiang Deng, Ye Li, Yanan Cui, Hua Zhang, Wenbing Dai, Bing He, Ying Zheng, Xueqing Wang, Qiang Zhang
Journal: Biomaterials (2018)
Nontraditional Risk Factors in Cardiovascular Disease Risk Assessment
Authors: Jennifer S. Lin, Corinne V. Evans, Eric Johnson, Nadia Redmond, Erin L. Coppola, Ning Smith
Journal: JAMA (2018)

<h3>Importance</h3> Incorporating nontraditional risk factors may improve the performance of traditional multivariable risk assessment for cardiovascular disease (CVD). <h3>Objective</h3> To systematically review evidence for the US Preventive Services Task Force on the benefits and harms of 3 nontraditional risk factors in cardiovascular risk assessment: the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) level, and coronary artery calcium (CAC) score. <h3>Data Sources</h3> MEDLINE, PubMed, and the Cochrane Central Register of Controlled Trials for studies published through May 22, 2017. Surveillance continued through February 7, 2018. <h3>Study Selection</h3> Studies of asymptomatic adults with no known cardiovascular disease. <h3>Data Extraction and Synthesis</h3> Independent critical appraisal and data abstraction by 2 reviewers. <h3>Main Outcomes and Measures</h3> Cardiovascular events, mortality, risk assessment performance measures (calibration, discrimination, or risk reclassification), and serious adverse events. <h3>Results</h3> Forty-three studies (N = 267 244) were included. No adequately powered trials have evaluated the clinical effect of risk assessment with nontraditional risk factors on patient health outcomes. The addition of the ABI (10 studies), hsCRP level (25 studies), or CAC score (19 studies) can improve both discrimination and reclassification; the magnitude and consistency of improvement varies by nontraditional risk factor. For the ABI, improvements in performance were the greatest for women, in whom traditional risk assessment has poor discrimination (C statistic change of 0.112 and net reclassification index [NRI] of 0.096). Results were inconsistent for hsCRP level, with the largest analysis (n = 166 596) showing a minimal effect on risk prediction (C statistic change of 0.0039, NRI of 0.0152). The largest improvements in discrimination (C statistic change ranging from 0.018 to 0.144) and reclassification (NRI ranging from 0.084 to 0.35) were seen for CAC score, although CAC score may inappropriately reclassify individuals not having cardiovascular events into higher-risk categories, as determined by negative nonevent NRI. Evidence for the harms of nontraditional risk factor assessment was limited to computed tomography imaging for CAC scoring (8 studies) and showed that radiation exposure is low but may result in additional testing. <h3>Conclusions and Relevance</h3> There are insufficient adequately powered clinical trials evaluating the incremental effect of the ABI, hsCRP level, or CAC score in risk assessment and initiation of preventive therapy. Furthermore, the clinical meaning of improvements in measures of calibration, discrimination, and reclassification risk prediction studies is uncertain.
Imaging the Vascular Bone Marrow Niche During Inflammatory Stress
Authors: Katrien Vandoorne, David Rohde, Hye-Yeong Kim, Gabriel Courties, Gregory Wojtkiewicz, Lisa Honold, Friedrich Felix Hoyer, Vanessa Frodermann, Ribhu Nayar, Fanny Herisson, Yookyung Jung, Pauline A. Désogère, Claudio Vinegoni, Peter Caravan, Ralph Weissleder, David E. Sosnovik, Charles P. Lin, Filip K. Swirski, Matthias Nahrendorf
Journal: Circulation Research (2018)

Rationale: Inflammatory stress induced by exposure to bacterial lipopolysaccharide causes hematopoietic stem cell expansion in the bone marrow niche, generating a cellular immune response. As an integral component of the hematopoietic stem cell niche, the bone marrow vasculature regulates the production and release of blood leukocytes, which protect the host against infection but also fuel inflammatory diseases. Objective: We aimed to develop imaging tools to explore vascular changes in the bone marrow niche during acute inflammation. Methods and Results: Using the TLR (Toll-like receptor) ligand lipopolysaccharide as a prototypical danger signal, we applied multiparametric, multimodality and multiscale imaging to characterize how the bone marrow vasculature adapts when hematopoiesis boosts leukocyte supply. In response to lipopolysaccharide, ex vivo flow cytometry and histology showed vascular changes to the bone marrow niche. Specifically, proliferating endothelial cells gave rise to new vasculature in the bone marrow during hypoxic conditions. We studied these vascular changes with complementary intravital microscopy and positron emission tomography/magnetic resonance imaging. Fluorescence and positron emission tomography integrin αVβ3 imaging signal increased during lipopolysaccharide-induced vascular remodeling. Vascular leakiness, quantified by albumin-based in vivo microscopy and magnetic resonance imaging, rose when neutrophils departed and hematopoietic stem and progenitor cells proliferated more vigorously. Conclusions: Introducing a tool set to image bone marrow either with cellular resolution or noninvasively within the entire skeleton, this work sheds light on angiogenic responses that accompany emergency hematopoiesis. Understanding and monitoring bone marrow vasculature may provide a key to unlock therapeutic targets regulating systemic inflammation.
The Prognostic Significance of Heart Rate in Patients Hospitalized for Heart Failure With Reduced Ejection Fraction in Sinus Rhythm
Authors: Stephen J. Greene, Muthiah Vaduganathan, Jane E. Wilcox, Matthew E. Harinstein, Aldo P. Maggioni, Haris Subacius, Faiez Zannad, Marvin A. Konstam, Ovidiu Chioncel, Clyde W. Yancy, Karl Swedberg, Javed Butler, Robert O. Bonow, Mihai Gheorghiade
Journal: JACC Heart Failure (2013)
Mitochondria Transfer from Hematopoietic Stem and Progenitor Cells to Pdgfrα+/Sca-1-/CD48dim BM Stromal Cells Via CX43 Gap Junctions and AMPK Signaling Inversely Regulate ROS Generation in Both Cell Populations
Authors: Karin Golan, Ashley Wellendorf, Yuji Takihara, Anju Kumari, Eman Khatib-Massalha, Orit Kollet, Hui Cheng, Tao Cheng, Mark J. Althoff, Shiri Gur-Cohen, Tomer Itkin, Marie-Dominique Fillipi, Jose A Cancelas, Toshio Suda, Tsvee Lapidot
Journal: Blood (2016)
Sedación con Propofol en la endoscopia digestiva: Tasa de complicación comparando los pacientes a partir de 75 años del resto de menor edad
Authors: AM Jurado Hernandez, ER Fuentes, JM Angel Rey, L Sevilla Caceres, A Pereñiguez Lopez, T Martinez Gimenez
Journal: Endoscopy (2017)

Estudio observacional retrospectivo de las exploraciones practicadas en la Unidad de Digestivo del Hospital Rafael Méndez de Lorca desde el 1 de Enero al 30 de junio de 2017, con objeto de examinar la tasa de complicaciones durante la sedación con propofol, administrada por el endoscopista, en la endoscopia digestiva, en los pacientes a partir de 75 años en comparación con el resto de menor edad.
Abstract 52: An Evidence Based Animal Model Of Prolonged Ventricular Fibrillation Cardiac Arrest
Authors: Timothy J Mader
Journal: Circulation (2007)

Background: Promising basic science findings in cardiac resuscitation often do not translate into improved outcomes when studied in humans. One explanation is that the current animal models do not adequately reflect the out-of-hospital cardiac arrest (OHCA) clinical trial environment. The author sought to review the literature and devise a new model of prolonged VF with time intervals that more accurately simulate OHCA conditions. Methods: A systematic review of the literature (01/90 –12/06) was conducted using PUBMED and a comprehensive list of appropriate MESH headings. All OHCA human clinical trials were included. The most relevant studies underwent explicit and detailed review. Mean values with 95%CI were calculated for each specified interval. Suitable conditions and establishment of appropriate times were then devised. Results: Twenty-two papers with adequate detail for evaluation were examined, leading to the following recommendations: the duration of non-treatment (assuming no bystander CPR or first-responders) is 11” (3” for recognition and EMS activation, 7” response interval and 1” for paramedics to reach the patient); chest compressions are initiated immediately with passive oxygen insufflation; assuming they can be done simultaneously, IV access and intubation (ETI) are accomplished 4” after arrival; drugs are delivered by minute 16 - well into the metabolic phase; and 2” of CPR are needed to circulate the drugs for the first rescue shock (RS) at minute 18. Conclusions: This proposed evidence based experimental model of prolonged untreated VF cardiac arrest has conditions and time intervals that simulate those of human OHCA clinical trials.
Visualización de la Papila de Vater en gastroscopias rutinarias
Authors: J García-Cano Lizcano, C Murillo Matamoros, M Muñiz Muñoz, M Suárez Matías, M Viñuelas Chicano, M Del Moral, L Valiente González, T Martínez Pérez, R Martínez Fernández, J Morillas Ariño
Journal: Endoscopy (2017)

Durante la gastroscopia convencional suele avanzarse el endoscopio hasta el comienzo de la segunda porción duodenal o zonal papilar. Sin embargo, la visualización de la Papila de Vater es difícil con la visión frontal de los gastroscopios. Por otro lado, en ocasiones una Papila de Vater normal, aunque prominente, puede confundirse con un pólipo duodenal. Nos propusimos estudiar la tasa de visualización de la Papila de Vater en una serie de gastroscopias rutinarias.
Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease
Authors: Richard Haynes, Parminder K. Judge, Natalie Staplin, William G. Herrington, Benjamin C. Storey, Angelyn Bethel, Louise Bowman, Nigel Brunskill, Paul Cockwell, Michael Hill, Philip A. Kalra, John J.V. McMurray, Maarten Taal, David C. Wheeler, Martin J. Landray, Colin Baigent
Journal: Circulation (2018)

Sacubitril/valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction, but its effects on kidney function and cardiac biomarkers in people with moderate to severe chronic kidney disease are unknown.The UK HARP-III trial (United Kingdom Heart and Renal Protection-III), a randomized double-blind trial, included 414 participants with an estimated glomerular filtration rate (GFR) 20 to 60 mL/min/1.73 m2 who were randomly assigned to sacubitril/valsartan 97/103 mg twice daily versus irbesartan 300 mg once daily. The primary outcome was measured GFR at 12 months using ANCOVA with adjustment for each individual's baseline measured GFR. All analyses were by intention to treat.In total, 207 participants were assigned to sacubitril/valsartan and 207 to irbesartan. Baseline measured GFR was 34.0 (SE, 0.8) and 34.7 (SE, 0.8) mL/min/1.73 m2, respectively. At 12 months, there was no difference in measured GFR: 29.8 (SE 0.5) among those assigned sacubitril/valsartan versus 29.9 (SE, 0.5) mL/min/1.73 m2 among those assigned irbesartan; difference, -0.1 (0.7) mL/min/1.73 m2. Effects were similar in all prespecified subgroups. There was also no significant difference in estimated GFR at 3, 6, 9, or 12 months and no clear difference in urinary albumin:creatinine ratio between treatment arms (study average difference, -9%; 95% CI, -18 to 1). However, compared with irbesartan, allocation to sacubitril/valsartan reduced study average systolic and diastolic blood pressure by 5.4 (95% CI, 3.4-7.4) and 2.1 (95% CI, 1.0-3.3) mm Hg and levels of troponin I and N terminal of prohormone brain natriuretic peptide (tertiary end points) by 16% (95% CI, 8-23) and 18% (95% CI, 11-25), respectively. The incidence of serious adverse events (29.5% versus 28.5%; rate ratio, 1.07; 95% CI, 0.75-1.53), nonserious adverse reactions (36.7% versus 28.0%; rate ratio, 1.35; 95% CI, 0.96-1.90), and potassium ≥5.5 mmol/L (32% versus 24%, P=0.10) was not significantly different between randomized groups.Over 12 months, sacubitril/valsartan has similar effects on kidney function and albuminuria to irbesartan, but it has the additional effect of lowering blood pressure and cardiac biomarkers in people with chronic kidney disease.URL: http://www.isrctn.com . Unique identifier: ISRCTN11958993.
Utilidad de los nuevos agentes hemostáticos en hemorragia digestiva alta: Análisis de nuestra experiencia
Authors: R Jiménez-Rosales, E Fernández-Fernández, F Vadillo-Calles, JG Martínez-Cara, F Valverde-López, P Abellán-Alfocea, EJ Ortega-Suazo, E Redondo-Cerezo
Journal: Endoscopy (2017)

El Hemospray es un agente hemostático consistente en un polvo inorgánico con doble mecanismo de acción: en contacto con el agua se vuelve adhesivo creando una barrera mecánica y favorece la formación del coágulo. Su principal ventaja es no precisar contacto con el tejido permitiendo su uso en lesiones de difícil acceso o difusas.
ADENOMA RECURRENCE RATE AFTER LEFT- VERSUS RIGHT-SIDED COLECTOMY FOR COLON CANCER; IS THERE REALLY A DIFFERENCE BETWEEN THE TWO GROUPS?
Authors: HS Moon, GY Yun, JS Kim, SH Kang, JK Sung, HY Jeong
Journal: Endoscopy (2018)

Patients with a history of colonic resection for cancer have an increased risk for the development of metachronous malignant lesions. However, data on detection rates of premalignant lesions during colonoscopy surveillance in this setting are scarce and the results were different. We have tried to confirm the results of previous studies, especially in the non-western societies.
Do women overreport nocturia?
Authors: J. Hotchkiss
Journal: BMJ (1995)

after extensive division of ahesions she was found to have moderate diverticular disease of the sigmoid colon with a loop stuck to the left posterolateral aspect of the uterus forming the fistulous communication.Given the degree of adhesions and the anatomy, she underwent a subtotal hysterectomy and oversewing of the colonic defect.Apart from a minor wound infection the remainder of her recovery was uneventful.Presumably the fistula resulted from trauma arising from the conduction of diathermy current during the endometrial ablation.While the introduction of minimally invasive but equiefficacious hysteroscopic techniques should be encouraged, serious complications may still arise.
Ensayo clínico de balón intra-gástrico preoperatorio previo a cirugía bariátrica y repercusion en la morbilidad postoperatoria
Authors: LR Rábago Torre, C Vicente Martinez, C Garcia-Ramos Garcia, M Perez Ferrer, I Maestro Prada, N Herrera Merino
Journal: Endoscopy (2017)

La cirugía bariátrica presenta una morbilidad postoperatoria importante y no hay muchos estudios que evalúen si la pérdida de peso conseguida influye en la disminución de las complicaciones postoperatorias.
UNDERWATER ENDOSCOPIC MUCOSAL RESECTION SHOWS COMPARABLE OUTCOMES THAN TRADITIONAL EMR WITH LESS ADVERSE EVENTS
Authors: J Rodríguez Sánchez, H Uchima, E de la Santa Belda, B López Viedma, J Olmedo Camacho
Journal: Endoscopy (2018)

Underwater endoscopic mucosal resection (UEMR) is an emerging resection technique, which is performed plunging the lesions in water without submucosal cushion. Somehow, the floating effect makes a feasible cutting line, and allows a safe resection. We aimed to evaluate the experience of two tertiary hospital using UEMR compared with traditional resection method for the treatment of non pedunculated colorectal polyps, focusing on the indication of both techniques.
Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development
Authors: Zev A. Binder, Amy Haseley Thorne, Spyridon Bakas, E. Paul Wileyto, Michel Bilello, Hamed Akbari, Saima Rathore, Sung Min Ha, Logan Zhang, Cole J. Ferguson, Sonika Dahiya, Wenya Linda Bi, David A. Reardon, Ahmed Idbaih, Joerg Felsberg, Bettina Hentschel, Michael Weller, Stephen J. Bagley, Jennifer J.D. Morrissette, MacLean P. Nasrallah, Jianhui Ma, Ciro Zanca, Andrew M. Scott, Laura Orellana, Christos Davatzikos, Frank B. Furnari, Donald M. O'Rourke
Journal: Cancer Cell (2018)
Abstract 17806: The Prognostic Importance of Frequent Premature Atrial Contractions Following Ischemic Cerebrovascular Events
Authors: John J Keaney, Layan Akijian, Doug Mulholland, Niamh Hannon, Danielle M Ní Chróinín, Gillian Horgan, Catherine McGorrian, Gavin Blake, Niall G Mahon, Lorraine Kyne, Joseph Duggan, Sean Murphy, Peter J Kelly
Journal: Circulation (2014)

Background: Following ischemic cerebrovascular accident (CVA) or transient ischemic attack (TIA) aggressive risk factor modification is undertaken to reduce the risk of recurrent events. Holter monitoring is advocated to facilitate the detection and treatment of Atrial Fibrillation (AF). Frequent Premature Atrial Contractions (PACs) are associated with the development of AF, but to date it is unknown whether the burden of PACs on Holters is of any prognostic importance following CVA/TIA. Objective: PACs on Holter monitoring may be a marker for recurrent cerebrovascular events post CVA/TIA. Methods: Retrospective analysis was performed on Holters of patients with CVA/TIA enrolled in a prior population based stroke study. Frequent PACs were defined as a rate of PACs ≥ 100 per 24 hours. The primary endpoint was recurrent CVA or TIA. Results: 84 cases (61.0% male) were reviewed. Mean age was 69.7 ± 12.4 years. Mean time to follow-up was 2514.6 ± 91.2 days. The average number of PACs in the frequent group (Hi-PAC, 21 patients) was 1610.8 ± 4541.4 compared with 21.8 ± 27.6 in those with less than 100 PACs (Lo-PAC, 63 patients). There was no statistically significant difference in age, gender, hypertension or diabetes between the two groups. On follow-up there were 20 recurrent events and 33 patients died. In the Hi-PAC group there were 8 (38.1%) recurrent events, and 16 (76.2%) patients died versus 12 (18.8%) and 17 (26.6%) respectively in Lo-PAC group. On Cox regression analysis the Hazard ratio (HR) for recurrent events was 2.75 (95% confidence interval (CI) 1.08 to 7.01). Kaplan Meier curves revealed a statistically significant difference in recurrance rates between the two groups (p &lt; 0.05). There was also a statistically significant difference in overall mortality on Kaplan Meier survival analysis (p &lt; 0.001), and with a hazard ratio on Cox regression analysis of 3.47 (95% CI 1.74 [[Unable to Display Character: &amp;#8211;]] 6.91). There was no significant difference in incidence of MI or AF. Conclusion: Frequent PACs on Holter monitor represent a significant risk factor for both recurrent events and mortality following CVA/TIA. Further prospective studies should be performed to assess whether these patients may benefit from more aggressive anticoagulation, similar to those with AF.
Acute Abdominal Pain in a Postmenopausal Woman
Authors: Carly M. Cooke, D. Blair Macdonald, Sukhbir S. Singh
Journal: JAMA Surgery (2018)

A postmenopausal woman presented with severe abdominal pain. Computed tomography revealed solid extracolonic implants, and magnetic resonance imaging showed 2 corresponding areas of focus. What is your diagnosis?
Transplant coordinators need more money for education
Authors: S. Falvey, V. Morgan
Journal: BMJ (1996)

EDITOR,—Celia Wight and Bernard Cohen point out that the fall in the numbers of organ donors due to declining death rates from intracranial haemorrhage and road traffic accidents should be welcomed.1 We would suggest that herein lies the most important limitation on the current transplantation programme. However, organ donation, as well as providing the obvious benefit to potential transplant recipients, can offer a bereaved family considerable comfort. It is the family's …
Abstract 16311: Echocardiographic Findings Predict Long-Term Mortality in Stroke Population
Authors: Leonid Garber, Jeremy A Miles, Daniel M Spevack
Journal: Circulation (2016)

Introduction:  Transthoracic echocardiography (TTE) has become a routine part of management for acute stroke to assess for cardiac sources of emboli. Many studies have illustrated a low diagnostic yield for sources of emboli on TTE, ranging from 3-10%. Little has been reported about the prognostic importance of TTE findings performed for evaluation of acute stroke.   Methods:  Brain imaging and TTE reports were reviewed for 3,920 consecutive patients presenting to an urban medical center with acute stroke between 1/1/01 and 9/30/07. Data was collected on baseline demographics, subtypes of stroke, abnormal TTE findings, and 10-year rates of readmission for stroke and mortality. Brain imaging showed evidence of recent or old infarction in 2,501.   Results:  Study patients were 67±15 years, 60% female, 75% minorities and had hypertension (75%), diabetes (41%), CKD (27%) and atrial fibrillation (18%). On TTE, a cardiac source (mass, thrombus or vegetation) was identified in only 14 cases (0.6%), whereas a clinically significant abnormality (EF   Conclusions:  Although TTE performed for ischemic stroke had minimal yield for identifying the source of embolization, clinically important abnormalities were common in this population. TTE abnormalities were independently associated with increased long-term mortality.