tbuckley/cabot-search huggingface dataset:
Post-Transplant Natural Antibodies Associate with Kidney Allograft Injury and Reduced Long-Term Survival
Authors: Sarah B. See, Olivier Aubert, Alexandre Loupy, Yokarla Veras, Xavier Lebreton, Baoshan Gao, Christophe Legendre, Dany Anglicheau, Emmanuel Zorn
Journal: Journal of the American Society of Nephrology (2018)

Background The development of antibodies specific to HLA expressed on donor tissue (donor-specific antibodies [DSAs]) is a prominent risk factor for kidney graft loss. Non-HLA antibodies with pathogenic potential have also been described, including natural antibodies (Nabs). These IgG Nabs bind to immunogenic self-determinants, including oxidation-related antigens. Methods To examine the relationship of Nabs with graft outcomes, we assessed Nabs in blinded serum specimens collected from a retrospective cohort of 635 patients who received a transplant between 2005 and 2010 at Necker Hospital in Paris, France. Serum samples were obtained immediately before transplant and at the time of biopsy-proven rejection within the first year or 1 year after transplant. Nabs were detected by ELISA through reactivity to the generic oxidized epitope malondialdehyde. Results Univariate Cox regression analysis identified the development of post-transplant Nabs (defined as 50% increase in reactivity to malondialdehyde) as a significant risk factor for graft loss (hazard ratio, 2.68; 95% confidence interval, 1.49 to 4.82; P =0.001). Post-transplant Nabs also correlated with increased mean Banff scores for histologic signs of graft injury in post-transplant biopsy specimens. Multivariable Cox analyses confirmed Nabs development as a risk factor independent from anti-HLA DSAs (hazard ratio, 2.07; 95% confidence interval, 1.03 to 4.17; P =0.04). Moreover, patients with Nabs and DSAs had a further increased risk of kidney graft loss. Conclusions These findings reveal an association between Nabs, kidney graft injury, and eventual graft failure, suggesting the involvement of Nabs in immune mechanisms of rejection.
EFFICACY OF SIMETHICONE AND N-ACETYLCYSTEINE COMBINATION PREMEDICATION PRIOR TO ESOPHAGOGASTRODUODENOSCOPY TO IMPROVE MUCOSAL VISIBILITY – A PROSPECTIVE DOUBLE BLINDED RANDOMIZED PLACEBO CONTROLLED TRIAL (CTRI/2017/09/009913)
Authors: K Veeraraghavan, J Abel, V Shreyas, TT Malini, D Vijayaraghavan, AV Sangeetha, G Kurien
Journal: Endoscopy (2018)

To detect whether the combination of Simethicone with N-Acetyl Cystiene as premedication before Upper GI endoscopy improves mucosal visualization?
TREATMENT OF BILIARY STRICTURES AFTER ORTHOTOPIC LIVER TRANSPLANTATION – A COMPARISON BETWEEN SELF-EXPANDABLE METAL STENTS AND PLASTIC STENTS
Authors: V Sandru, M Ilie, O Plotogea, C Diaconu, B Ungureanu, A Constantinescu, G Constantinescu
Journal: Endoscopy (2018)

To assess the stricture resolution in orthotopic liver transplantation (OLT) patients by ERCP stent placement in a tertiary care hospital.
From Guideline to Order Set to Patient Harm
Authors: Sachin D. Shah, Adam S. Cifu
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differenzial Diagnosis of Pancreatic Cancer from Normal Tissue Using Digital Imaging Processing and Pattern Recognition based on Support Vector Machine of EUS Images
Authors: Zhang MinMin, Yang Hua, Jin ZhenDong, Li ZhaoShen, Yu JianGuo, Cai ZheYuan
Journal: Endoscopy (2011)

Endoscopic ultrasonography (EUS) can detect morphologic abnormalities of pancreatic cancer with high sensitivity, but with limited specificity. In the present study, we applied digital imaging processing (DIP) technique to EUS images of pancreas to develop a classification model for differenzial diagnosis of pancreatic cancer.
Dosing de novo two-drug combinations based on 32,894 patients in phase I-III clinical trials.
Authors: Mina Nikanjam, Sariah Liu, Razelle Kurzrock
Journal: Journal of Clinical Oncology (2016)

2563 Background: Metastatic cancers harbor complex genomic alterations. Combinations are needed to attenuate resistance. Knowledge of appropriate starting doses for novel drug combinations in clinical trials and practice is lacking. Literature review was used to help inform selection of safe starting doses for two-drug combinations involving a targeted agent. Methods: Phase I-III adult oncology clinical trial publications (Jan. 1, 2010 to Dec. 31, 2013; PubMed) were reviewed. The dose of drug used in each combination was compared to the single agent recommended dose (FDA-approved/recommended phase 2 dose (RP2D)/maximum tolerated dose (MTD)). Dose percentages were calculated as: (safe dose of drug in combination/dose of drug as single agent at FDA/RP2D/MTD) X 100. Additive dose percentages were the sum of the dose percentage for each drug. Results: 144 studies (N = 8,568 patients; 95 combinations) of dual targeted agents and 372 studies (N = 24,326 patients; 248 drug combinations) with a targeted and cytotoxic agent were analyzed. Each agent could be administered at 100% of their standard dose in 51% (two targeted agents) and 38% of trials (cytotoxic and targeted agent), respectively. Median and lowest safe additive dose percentages are summarized in the Table. Dual targeted agent dosages were limited by overlapping targets, same drug class, and mTor inhibitors (lowest safe additive dose percentage of 60%), while targeted-cytotoxic combinations were limited by the presence of a PARP or HDAC inhibitor (lowest additive percentage of 41%). In the absence of these factors, the lowest safe additive dose percentage was 143% (dual targeted agents) and 82% (targeted-cytotoxic). Conclusions: The current findings can help inform safe starting doses for novel two-drug combinations in the context of clinical trials and practice. Dual Targeted Targeted-Cytotoxic Lowest Safe Additive Dose Percentage 60% 143% (for non-overlapping targets/different classes) 41% 82% (without HDAC/PARP inhibitors) Lowest Safe Additive Dose Percentage with One Agent at 100% of Single Agent Recommended Dose 125% 117% (cytotoxic agent 100%) 136% (targeted agent 100%) Median Safe Additive Dose Percentage (Range) 200% (60% – 200%) 180% (41% - 200%)
ENDOSCOPIC PANCREATIC SPHINCTEROTOMY IMPROVES SYMPTOMS OF PAIN RELATED TO BRANCH-DUCT INTRA-PAPILLARY MUCINOUS NEOPLASIA WITHOUT WORRISOME FEATURES AND DELAY AN AVOIDABLE SURGERY. A MULTICENTER STUDY
Authors: JM Gonzalez, D Lorenzo, JP Ratone, A Culetto, F Maire, P Lévy, M Barthet
Journal: Endoscopy (2018)

Branch Duct intraductal papillary mucinous neoplasms (BD-IPMNs) require follow-up to detect worrisome features (WF). Data are missing about endoscopic pancreatic sphincterotomy (PS) for symptomatic IPMN. The aim is to assess the efficacy of endoscopic pancreatic sphincterotomy in the treatment of BD-IPMN without WF, and to document the evolution with regards to evolution towards malignancy.
OPTIMAL NAOH CONCENTRATION IN THE EXPERIMENTAL MODEL OF BENIGN ESOPHAGEAL STENOSIS IN RATS
Authors: W Jiang, L Chen, Y Wang
Journal: Endoscopy (2018)

The optimal concentration of alkali applied which can achieve both extremely satisfying success rate of establishing experimental models and high survival rate still needs further investigation. Our study aimed to investigate the optimal concentration of sodium NaOH to establish a BES model in rats.
Gut microbiome modulates efficacy of immune checkpoint inhibitors
Authors: Ming Yi, Shengnan Yu, Shuang Qin, Qian Liu, Hanxiao Xu, Weiheng Zhao, Qian Chu, Kongming Wu
Journal: Journal of Hematology & Oncology (2018)

Immune checkpoint inhibitors (ICIs) therapy is a novel strategy for cancer treatments in recent years. However, it was observed that most patients treated with ICIs could not get benefit from the therapy, which led to the limitation of clinical application. Motivated by potent and durable efficacy of ICIs, oncologists endeavor to explore the mechanisms of resistance to ICIs and increase the drug sensitivity. It is known that heterogeneity of gut microbiome in populations may result in different outcomes of therapy. In xenograft model, bacteria in gut have been proved as a crucial factor regulating immunotherapy efficacy. And the similar phenomenon was obtained in patients. In this review, we summarized relevant advancements about gut microbiome and ICIs. Furthermore, we focused on modulatory function of gut microbiome in ICIs therapy and possible antitumor mechanism of specific commensals in ICIs treatment. We propose that gut microbiome is an important predictive factor, and manipulation of gut microbiome is feasible to elevate response rate in ICIs therapy.
Sténoses du 1/3 supérieur de l'œsophage: intérêt des prothèses à collerettes supérieures courtes
Authors: C Pesenti, F Caillol, E Bories, M Giovannini
Journal: Endoscopy (2009)

Introduction: Les prothèses oesophagiennes expansibles sont utilisées comme traitement des sténoses malignes, des fistules, ou plus rarement pour calibration des sténoses bénignes. Leur tolérance et souvent médiocre au niveau du 1/3 supérieur à proximité du Killian. Nous rapportons notre expérience de manière rétrospective sur l'utilisation de prothèses à collerettes supérieures courtes.
Abstract P221: Combined Low Vitamin D and K Status is Associated With Greater Left Ventricular Mass
Authors: Sharon Remmelzwaal, Joline Beulens, Petra J Elders, Jacqueline M Dekker, Coen D Stehouwer, Hanne Van Ballegooijen
Journal: Circulation (2018)

Introduction: Low vitamin D and vitamin K status are both associated with cardiovascular disease risk. New evidence from experimental studies on bone health suggest an interaction between vitamin D and K, however, a joint association with vascular health outcomes is largely unknown. Hypothesis: We assessed the hypothesis that combined low vitamin D and low vitamin K status is prospectively associated with unfavorable measures of cardiac structure and function. Methods: In the Hoorn Study, a population-based cohort study of 598 participants, mean age 70.1±6.6 years, 51% female, had physical examinations in 2000-2001 (baseline for the current analyses), and of these 265 had a follow-up in 2007-2009. In baseline samples, vitamin D and K status were assessed by measuring 25-hydroxyvitamin D [25(OH)D] and dephosphorylated uncarboxylated matrix gla protein (dp-ucMGP). High dp-ucMGP is indicative of a low vitamin K status. We studied the combined association of 25(OH)D and dp-ucMGP with echocardiographic measures of left ventricular mass index, left ventricular ejection fraction and left atrium volume index after 8 years of follow-up using linear regression analyses. The group high 25(OH)D/low dp-ucMGP was the reference group. We adjusted our analyses for potential confounders including follow-up time and baseline echocardiographic measures. Results: Mean 25(OH)D was 57.8 nmol/L and median was dp-ucMGP was 567 pmol/L. The low 25(OH)D/high dp-ucMGP category was associated with a greater left ventricle mass index:4.8 g/m 2.7 (95% CI 0.6, 9.1) at follow-up compared to the reference group, in the fully adjusted model (Table 1). No associations were observed between 25(OH)D and dp-ucMGP categories with systolic and diastolic function after 8 years of follow-up. Conclusion: In conclusion, these results suggest that high levels of 25(OH)D and low levels of dp-ucMGP are associated with a greater left ventricle mass index. Vitamin D and K supplementation trials are the next step to assess a causal relationship with cardiac structure.
COMPARISON OF EUS-GUIDED FINE NEEDLE BIOPSY TECHNIQUES FOR CORE TISSUE ACQUISITION AND DIAGNOSTIC PERFORMANCES IN PANCREATIC SOLID LESIONS
Authors: CM Cho, AN Seo, HI Bae
Journal: Endoscopy (2018)

The acquisition of core tissue in endoscopic ultrasound-guided tissue sampling (EUS-TS) is necessary for histologic diagnosis and immunohistochemical staining in the diagnosis of some solid mass lesions. Although recent studies revealed the superiority of core biopsy needle in the specimen adequacy, controversy still remains that which EUS-TS techniques would contribute better results. The aim of our study was to evaluate EUS-TS techniques with a ProCore needle using suction and slow pull suction for solid pancreatic lesions without an on-site cytopaphologist.
The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma
Authors: Mantang Qiu, Wenjia Xia, Rui Chen, Siwei Wang, Youtao Xu, Zhifei Ma, Weizhang Xu, Erbao Zhang, Jie Wang, Tian Fang, Jingwen Hu, Gaochao Dong, Rong Yin, Jun Wang, Lin Xu
Journal: Cancer Research (2018)

Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs. By integrating bioinformatics analyses of alerted circRNAs and focal CNV in lung adenocarcinoma, we identify a proto-oncogenic circular RNA (circPRKCI) from the 3q26.2 amplicon, one of the most frequent genomic aberrations in multiple cancers. circPRKCI was overexpressed in lung adenocarcinoma tissues, in part due to amplification of the 3q26.2 locus, and promoted proliferation and tumorigenesis of lung adenocarcinoma. circPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7 Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model. In summary, circPRKCI is crucial for tumorigenesis and may serve as a potential therapeutic target in patients with lung adenocarcinoma.Significance: These findings reveal high expression of the circular RNA circPRKCI drives lung adenocarcinoma tumorigenesis. Cancer Res; 78(11); 2839-51. ©2018 AACR.
WIRELESS ESOPHAGEAL PH MONITORING FOR THE EVALUATION OF GASTROESOPHAGEAL REFLUX. INITAL EXPERIENCE
Authors: S Bacchiddu, E Espinet Coll, C Hernández Ballesteros, C Vila Lolo, E Vidal Gispert, JA Gómez Valero, D Maluenda Colomer, E Hernández Ramos, A Juan-Creix Comamala
Journal: Endoscopy (2018)

Wireless esophageal pH monitoring (Bravo® system) consists of a small capsule endoscopically placed into the esophageal lumen which measures pH and transmits the data to an external receiver, without the need for a nasal probe and allowing a more than 24 hours recording.
Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project
Authors: Katrin M Sjoquist, Lindsay A Renfro, R John Simes, Niall C Tebbutt, Stephen Clarke, Matthew T Seymour, Richard Adams, Timothy S Maughan, Leonard Saltz, Richard M Goldberg, Hans-Joachim Schmoll, Eric Van Cutsem, Jean-Yves Douillard, Paulo M Hoff, Joel Randolph Hecht, Christophe Tournigand, Cornelis J A Punt, Miriam Koopman, Herbert Hurwitz, Volker Heinemann, Alfredo Falcone, Rainer Porschen, Charles Fuchs, Eduardo Diaz-Rubio, Enrique Aranda, Carsten Bokemeyer, Ioannis Souglakos, Fairooz F Kabbinavar, Benoist Chibaudel, Jeffrey P Meyers, Daniel J Sargent, Aimery de Gramont, John R Zalcberg
Journal: JNCI Journal of the National Cancer Institute (2017)

Estimating prognosis on the basis of clinicopathologic factors can inform clinical practice and improve risk stratification for clinical trials. We constructed prognostic nomograms for one-year overall survival and six-month progression-free survival in metastatic colorectal carcinoma by using the ARCAD database. Data from 22 674 patients in 26 randomized phase III clinical trials since 1997 were used to construct and validate Cox models, stratified by treatment arm within each study. Candidate variables included baseline age, sex, body mass index, performance status, colon vs rectal cancer, prior chemotherapy, number and location of metastatic sites, tumor mutation status (BRAF, KRAS), bilirubin, albumin, white blood cell count, hemoglobin, platelets, absolute neutrophil count, and derived neutrophil-to-lymphocyte ratio. Missing data (<11%) were imputed, continuous variables modeled with splines, and clinically relevant pairwise interactions tested if P values were less than .001. Final models were internally validated via bootstrapping to obtain optimism-corrected calibration and discrimination C-indices, and externally validated on a 10% holdout sample from each trial (n = 2257). In final models, all included variables were associated with overall survival except for lung metastases, and all but total white cell count associated with progression-free survival. No clinically relevant pairwise interactions were identified. Final nomogram calibration was good (C = 0.68 for overall and C = 0.62 for progression-free survival), as was external validity (concordance between predicted >50% vs < 50% probability) and actual (yes/no) survival (72.8% and 68.2% concordance, respectively, for one-year overall and six-month progression-free survival, between predicted [>50% vs < 50% probability] and actual [yes/no] overall and progression-free survival). Median survival predictions fell within the actual 95% Kaplan-Meier confidence intervals. The nomograms are well calibrated and internally and externally valid. They have the potential to aid prognostication and patient-physician communication and balance risk in colorectal cancer trials.
AGGRESSIVE INTRAVENOUS HYDRATION WITH LACTATED RINGER'S SOLUTION REDUCES THE DEVELOPMENT OF POST-ERCP PANCREATITIS
Authors: M Alcivar-Leon, A Serrano-Suarez, J Carrillo-Ubidia, ML Jara Alba, D Marriott-Blum, L Frugone-Morla, I Nieto-Orellana, K Mönkemüller, E Marriott-Diaz
Journal: Endoscopy (2018)

To determine whether aggressive periprocedural hydration with lactated Ringer's solution reduces the incidence of post-ERCP pancreatitis (PEP).
SERUM PHOSPHATE AS A PROGNOSTIC FACTOR IN POST-ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY PANCREATITIS
Authors: YH Choi, DK Jang, YT Kim, JK Ryu, WH Paik, J Kang, JH Choi, SH Lee
Journal: Endoscopy (2018)

There is no definite prognostic marker of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). Previous animal study reported that serum phosphate correlated with severity of acute pancreatitis. In this study, we aimed to evaluate the efficacy of serum phosphate as a prognostic factor for PEP in human.
Ethics in publication, part 2: duplicate publishing, salami slicing, and large retrospective multicenter case series
Authors: Michael Wallace, Deborah Bowman, Hilary Hamilton-Gibbs, Peter Siersema
Journal: Endoscopy (2018)

Abbreviations COI: conflict of interest COPE: International Committee on Publication Ethics ICMJE: International Committee of Medical Journal Editors IRB: institutional review board LAMS: lumen-apposing metal stent POEM: per-oral endoscopic myotomy SAE: serious adverse event
Abstract MP40: Associations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cardiovascular Mortality Risk
Authors: Marta Guasch, Geng Zong, Walter Willett, Peter Zock, Anne Wanders, Frank Hu, Qi Sun
Journal: Circulation (2018)

Background: Studies regarding monounsaturated fatty acid(MUFA) intake and mortality have reported inconsistent findings.Dietary MUFAs can come from both plant and animal sources with divergent nutrient components that potentially obscure the associations for total MUFAs. Hypothesis: We hypothesized that MUFA from plant sources(MUFA-P) is more likely to be inversely associated with mortality than MUFA from animal sources (MUFA-A).Replacing saturated fatty acids(SFA), trans fat,or refined carbohydrates by MUFA-P would be associated with a lower risk. Methods: We included 63,412 women from the Nurses’ Health Study(1990-2012) and 29,966 men from Health Professionals Follow-up Study(1990-2010). MUFA-Ps and MUFA-As were calculated based on validated food frequency questionnaires collected every 4-y and food composition databases that capture changes in composition over time. Results: During 1,896,864 person-years of follow-up, 20,672 total and 4,588 cardiovascular deaths occurred.MUFA-P was inversely associated with total mortality after adjusting for potential confounders [HR:0.84(95%CI:0.79,0.89) P &lt;0.01], whereas MUFA-A was associated with higher risk [1.21(1.07,1.37), P &lt;0.01].Isocalorically replacing SFAs (5% of total energy), refined carbohydrates (5% energy),or trans fat (2% energy) with MUFA-Ps was associated with 15%, 14%, and 10% lower risk of total mortality, respectively. Mortality risk was 24% lower when MUFA-Ps were modelled to replace MUFA-As(5% energy),and 20% lower when the sum of SFAs and MUFA-As(5% energy) was replaced.Similar results were observed for cardiovascular mortality for the same substitutions:HR(95%CI) were 0.74 (0.64, 0.85; P &lt;0.01) for replacing MUFA-A and 0.83 (0.76, 0.92; P &lt;0.01) for replacing SFA+MUFA-A. Conclusions: Higher MUFA-P intake was associated with lower total mortality and MUFA-A was associated with higher mortality.Significantly lower mortality was observed when SFAs, trans fats,or refined carbohydrates were replaced by MUFA-P, but not MUFA-A.
FREQUENCY OF CELIAC DISEASE IN PATIENTES WHO COMBINED LOW PLASMA IRON AND VITAMIN B12 AND EVALUATION WITH MAGNIFIED UPPER GASTROINTESTINAL ENDOSCOPY
Authors: Ö Burcak Binicier, S Akay
Journal: Endoscopy (2018)

Celiac disease (CD) is characterized with malabsorption. The gold standard for the diagnosis is histopatological findings confirmed with the serologic tests. Herein we aimed to study the frequency of CD and evaluate whether the magnified endoscopy and magnified FICE (Fujinon Intelligence Color Enhancement) techniques do contribute the diagnosis in patients with combined decreased serum iron and vitamin B12 levels.
Malignant melanoma associated with chronic once-daily aspirin exposure in males: A large, single-center, urban, US patient population cohort study from the “Research on Adverse Drug events And Report” (RADAR) project
Authors: Kelsey A. Orrell, Ahuva D. Cices, Nicholas Guido, Sara Majewski, Erin Ibler, Thy Huynh, Stephanie M. Rangel, Anne E. Laumann, Mary C. Martini, Alfred W. Rademaker, Dennis P. West, Beatrice Nardone
Journal: Journal of the American Academy of Dermatology (2018)
Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non–Small Cell Lung Cancer
Authors: Daisuke Shibahara, Kentaro Tanaka, Eiji Iwama, Naoki Kubo, Keiichi Ota, Koichi Azuma, Taishi Harada, Jiro Fujita, Yoichi Nakanishi, Isamu Okamoto
Journal: Journal of Thoracic Oncology (2018)
EUS GUIDED DILATATION OF STRICTURED BILIO-ENTERIC ANASTOMOSES (BEA)
Authors: P Nemade, S Kumar Korrapati, M Mahadik, J Bapaye, A Bapaye
Journal: Endoscopy (2018)

Treatment of strictured bilioenteric anastomosis (BEA) is required in 3 – 5% patients. Percutaneous, endoscopic (overtube assisted enteroscopy (OAE) or EUS guided) or surgical approaches are described. Percutaneous & surgical approaches have high morbidity whereas OAE guided endoscopic approach has poor success rates. EUS guided dilatation of HJ strictures has been described earlier. This study reports results of patients treated by EUS guided dilatation of BEA strictures.