tbuckley/cabot-search huggingface dataset:
Movie Review of <i>The Immortal Life of Henrietta Lacks</i>
Authors: Mary L. (Nora) Disis
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and safety of calcipotriol (MC 903) ointment in psoriasis vulgaris
Authors: Louis Dubertret, Daniel Wallach, Pierre Souteyrand, Marc Perussel, Bernard Kalis, Jean Meynadier, Jacqueline Chevrant-Breton, Claire Beylot, Jacques A. Bazex, Hans Jessen Jurgensen
Journal: Journal of the American Academy of Dermatology (1992)
The effect of smoking on exacerbation risk in eosinophilic patients with COPD
Authors: Marjan Kerkhof, Elizabeth V. Hillyer, David B. Price
Journal: European Respiratory Journal (2017)

We thank C.R. Osadnik and co-workers for raising these comments and would like to explain the rationale behind our chosen strategy of analyses. Adjusting for prior history of outcome variable may lead to overadjustment bias in observational studies <http://ow.ly/627230gCBFd>
Особливості діагностики енцефалопатії у хворих з синдромом портальної гіпертензії
Authors: Yu.M. Stepanov, N.V. Chaliy, S.L. Меlanich
Journal: GASTROENTEROLOGY (2017)

Актуальність. Печінкова енцефалопатія — патологічні зміни функцій головного мозку незапального генезу, що проявляються синдромом вторинних неврологічних і когнітивних розладів, спричинених комплексом глибоких метаболічних порушень, в результаті гострої печінкової недостатності, хронічних захворювань печінки або портосистемного шунтування крові. Початкова стадія енцефалопатії не має клінічних неврологічних симптомів, але визначається у 20–80 % хворих на цироз печінки і на відміну від кінцевих стадій є оборотною. Мета дослідження: оцінити ефективність тесту зв’язку чисел, флікер-тесту та електроенцефалографії в діагностиці енцефалопатії у хворих з печінковою та позапечінковою формою портальної гіпертензії. Матеріали та методи. Синдром печінкової енцефалопатії вивчено у 50 хворих з печінковою формою портальної гіпертензії, 30 хворих з позапечінковою формою портальної гіпертензії та 25 осіб без ознак портальної гіпертензії. Для діагностики використовували тест зв’язку чисел, флікер-тест та електроенцефалографію. Результати. Тест зв’язку чисел дозволив встановити ознаки печінкової енцефалопатії майже в усіх хворих незалежно від наявності та форми портальної гіпертензії. Однак прояви печінкової енцефалопатії за частотою і за вираженістю переважали у хворих з печінковою портальною гіпертензією. Проведення флікер-тесту дозволило діагностувати мінімальну печінкову енцефалопатію у 96 % хворих з печінковою портальною гіпертензією та 60 % хворих з позапечінковою портальною гіпертензією. Виконання електроенцефалографії визначило наявність печінкової енцефалопатії у 60 % хворих з печінковою портальною гіпертензією, 50 % хворих з позапечінковою портальною гіпертензією та 12 % хворих без портальної гіпертензії. Висновки. Зіставлення ефективності діагностичних тестів показало, що простий у виконанні і доступний тест зв’язку чисел є найбільш ефективним, однак і інші тести мають свої позитивні сторони в клінічній оцінці печінкової енцефалопатії у хворих з портальною гіпертензією.
Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation
Authors: Sophie Glatt, Dominique Baeten, Terry Baker, Meryn Griffiths, Lucian Ionescu, Alastair D G Lawson, Ash Maroof, Ruth Oliver, Serghei Popa, Foteini Strimenopoulou, Pavan Vajjah, Mark I L Watling, Nataliya Yeremenko, Pierre Miossec, Stevan Shaw
Journal: Annals of the Rheumatic Diseases (2017)

Objective Interleukin (IL)-17A has emerged as pivotal in driving tissue pathology in immune-mediated inflammatory diseases. The role of IL-17F, sharing 50% sequence homology and overlapping biological function, remains less clear. We hypothesised that IL-17F, together with IL-17A, contributes to chronic tissue inflammation, and that dual neutralisation may lead to more profound suppression of inflammation than inhibition of IL-17A alone. Methods Preclinical experiments assessed the role of IL-17A and IL-17F in tissue inflammation using disease-relevant human cells. A placebo-controlled proof-of-concept (PoC) clinical trial randomised patients with psoriatic arthritis (PsA) to bimekizumab (n=39) or placebo (n=14). Safety, pharmacokinetics and clinical efficacy of multiple doses (weeks 0, 3, 6 (240 mg/160 mg/160 mg; 80 mg/40 mg/40 mg; 160 mg/80 mg/80 mg and 560 mg/320 mg/320 mg)) of bimekizumab, a humanised monoclonal IgG1 antibody neutralising both IL-17A and IL-17F, were investigated. Results IL-17F induced qualitatively similar inflammatory responses to IL-17A in skin and joint cells. Neutralisation of IL-17A and IL-17F with bimekizumab more effectively suppressed in vitro cytokine responses and neutrophil chemotaxis than inhibition of IL-17A or IL-17F alone. The PoC trial met both prespecified efficacy success criteria and showed rapid, profound responses in both joint and skin (pooled top three doses vs placebo at week 8: American College of Rheumatology 20% response criteria 80.0% vs 16.7% (posterior probability &gt;99%); Psoriasis Area and Severity Index 100% response criteria 86.7% vs 0%), sustained to week 20, without unexpected safety signals. Conclusions These data support IL-17F as a key driver of human chronic tissue inflammation and the rationale for dual neutralisation of IL-17A and IL-17F in PsA and related conditions. Trial registration number NCT02141763; Results.
Abstract 13293: Instability of the Mechanosensory Domain of Platelet Glycoprotein GPIbα Underlies the Pathophysiology of Bernard-Soulier Syndrome
Authors: Xiaoqin Zhang, Lanbo Liu, Yue Tao, Xi Mo, Renhao Li
Journal: Circulation (2016)

Glycoprotein (GP)Ib-IX complex is a highly expressed receptor complex on the platelet surface and plays a critical role in platelet activation and clearance. It consists of GPIbα, GPIbβ and GPIX subunits, with GPIbα containing the ligand-binding domain for von Willebrand factor (VWF) and other hemostatically important proteins. Bernard-Soulier syndrome (BSS), a rare hereditary bleeding disorder, is characterized by the abnormally low expression of functional GPIbα on the platelet surface. Previous studies of GPIb-IX expression in platelets and transfected Chinese hamster ovary (CHO) cells have showed that efficient surface expression of GPIbα requires its coexpression and proper assembly with GPIbβ and GPIX. However, the molecular basis underlying the fast degradation and low surface expression of GPIbα in the absence of GPIbβ and GPIX has remained unclear. Since the recently identified mechanosensory domain of GPIbα is not stable in isolation, we tested here whether it plays a role in influencing GPIbα expression in transfected CHO cells. Removal of this domain produced the first GPIbα variant (GPIbαΔ417-483) that could express alone in the plasma membrane at a level comparable to that of GPIbα in the wild-type GPIb-IX complex. Further analysis of mutational effects on GPIbα expression detected by flow cytometry and Western blot suggests that in the absence of GPIbβ and GPIX residues 461-483 confer GPIbα the vulnerability to degradation and low surface expression in transfected CHO cells. The underlying reason is being explored, but it is not due to the heightened exposure of the ADAM17 cleavage site because surface expression levels of various GPIbα variants in transfected CHO M2 cells, which lack a functional ADAM17, was very similar to those in wild-type CHO cells. In conclusion, we have identified for the first time high-expressing GPIba variants that retain native VWF-binding activity and intracellular signaling sequence, which will help to shed important insights on BSS pathogenesis and GPIb-IX structure-function.
Fractional ablative carbon-dioxide laser treatment improves histologic and clinical aspects of striae gravidarum: A prospective open label paired study
Authors: Elisete Isabel Crocco, Guilherme Muzy, Natalia M. Schowe, Marilia S. Albuquerque, Mirna D. Barros, Hudson S. Buck
Journal: Journal of the American Academy of Dermatology (2017)
Abstract 14731: Sinus Node Recovery Time and Minor Allele of ZFHX3 SNP Were Independent Predictors of Atrial Fibrillation Recurrence After Pulmonary Vein Isolation
Authors: Sunsuke Tomomori, Yukiko Nakano, Takehito Tokuyama, Akinori Sairaku, Hiroya Matsumura, Michitaka Amioka, Naoya Hironobe, Yasuki Kihara
Journal: Circulation (2016)

Background: The AF related SNPs have been reported to be associated with the outcomes after AF ablation, but it remains controversial. We investigated the predictors of paroxysmal AF (PAF) recurren...
MICRA: an automatic pipeline for fast characterization of microbial genomes from high-throughput sequencing data
Authors: Ségolène Caboche, Gaël Even, Alexandre Loywick, Christophe Audebert, David Hot
Journal: Genome biology (2017)

The increase in available sequence data has advanced the field of microbiology; however, making sense of these data without bioinformatics skills is still problematic. We describe MICRA, an automatic pipeline, available as a web interface, for microbial identification and characterization through reads analysis. MICRA uses iterative mapping against reference genomes to identify genes and variations. Additional modules allow prediction of antibiotic susceptibility and resistance and comparing the results of several samples. MICRA is fast, producing few false-positive annotations and variant calls compared to current methods, making it a tool of great interest for fully exploiting sequencing data.
Improving P300 spelling rate using language models and predictive spelling
Authors: William Speier, Corey Arnold, Nand Chandravadia, Dustin Roberts, Shrita Pendekanti, Nader Pouratian
Journal: Brain-Computer Interfaces (2017)

The P300 Speller Brain-Computer Interface (BCI) provides a means of communication for those suffering from advanced neuromuscular diseases such as amyotrophic lateral sclerosis (ALS). Recent literature has incorporated language-based modelling, which uses previously chosen characters and the structure of natural language to modify the interface and classifier. Two complementary methods of incorporating language models have previously been independently studied: predictive spelling uses language models to generate suggestions of complete words to allow for the selection of multiple characters simultaneously, and language model-based classifiers have used prior characters to create a prior probability distribution over the characters based on how likely they are to follow. In this study, we propose a combined method which extends a language-based classifier to generate prior probabilities for both individual characters and complete words. In order to gauge the efficiency of this new model, results across 12 healthy subjects were measured. Incorporating predictive spelling increased typing speed using the P300 speller, with an average increase of 15.5% in typing rate across subjects, demonstrating that language models can be effectively utilized to create full word suggestions for predictive spelling. When combining predictive spelling with language model classification, typing speed is significantly improved, resulting in better typing performance.
A Baby-Led Approach to Complementary Feeding
Authors: Lakshmi Gribble, Sowmya Gandham, Alison Poulton
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Clinical next generation sequencing for precision oncology in rare cancers.
Authors: Roman Groisberg, David S. Hong, Filip Janku, Apostolia Maria Tsimberidou, Milind M. Javle, Funda Meric-Bernstam, Vivek Subbiah
Journal: Journal of Clinical Oncology (2017)

2582 Background: Rare tumors receive little financial support or interest from major drug developers or clinical investigators. They are by nature difficult to study even in a large academic medical center. As such, no standard of care exists for many of these cancers and treatment is often extrapolated. ESMO defines rare tumors as 5/100,000 persons per year. We examined patients with rare tumors for potentially targetable genomic alterations using next generation exome sequencing (NGS). Methods: We reviewed charts of patients with rare tumors per the ESMO definition. Sarcomas were excluded. Patients were referred to investigational therapeutics department and underwent CLIA certified comprehensive genomic profiling (Foundation Medicine). Actionable alterations were defined as targeted by a drug available on-label, off-label, or in clinical trials. Results: Among the 95 patients analyzed median age was 51 years (range 2-75). M:F ratio 46:49. Overall, there were 47 different subtypes in our dataset with the most common being adenoid cystic (13%), cholangiocarcinoma (7%), metaplastic breast (6%), gallbladder (5%), and carcinoid (4%). Eighty-seven out of 96 patients (92%) had at least one genomic alteration identified with mean of 2.6 mutations per patient. Of the patients with identifiable mutations, the most common were TP53 (23%), KRAS (10%), PIK3CA (9%), CDKN2A/B (8%), BRAF (7%), MLL (7%), and ARID1A (6%). Thirty-six patients (38%) had at least one potentially actionable alteration in 21 different tumors (eg: PI3K in metaplastic breast and adenoid cystic carcinomas and BRAF V600E in Erdheim-Chester disease). Nine patients received targeted therapy. Of these 9 patients, 3 had PR, 4 had SD, and 2 had PD as best response (table). Conclusions: The addition of CGP to management of rare tumors adds a potential line of therapy especially in RAF pathway altered ultra-rare cancers that have no standard of care. [Table: see text]
Access to Health Care
Authors: Marc Gourevitch
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 September 1990Access to Health CareMarc Gourevitch, MD, Mack Lipkin Jr., MD, James A. Bryan, MDMarc Gourevitch, MDSearch for more papers by this author, Mack Lipkin Jr., MDSearch for more papers by this author, James A. Bryan, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-6-478 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: We strongly support a system of universal health insurance as thoughtfully discussed in the American College of Physicians' recent position paper (1). However, although universal coverage might result in a net decrease in the weight of bureaucracy and regulation (2), most physicians fear the opposite. In the current climate of physician hostility to "bureaucracy," many oppose universal coverage for fear of further loss of autonomy and increased and noxious scrutiny of their every decision. This tension between resistance to greater bureaucratic intrusion and recognition that the current system is inadequate must be addressed.Physicians' apprehensions are well-founded....References1. . Access to health care. Ann Intern Med. 1990;112:641-61. LinkGoogle Scholar2. HimmelsteinWoolhandler DS. Cost without benefit. Administrative waste in U.S. health care. N Engl J Med. 1986;314:441-5. CrossrefMedlineGoogle Scholar3. Belkin L. Many in medicine see rules sapping profession's morale. New York Times. 19 February 1990:1. Google Scholar4. Radovsky S. U.S. medical practice before Medicare and now—differences and consequences. N Engl J Med. 1990;322:263-7. CrossrefMedlineGoogle Scholar1. . Access to health care. Ann Intern Med. 1990;112:641-61. LinkGoogle Scholar1. GreenbergerDaviesMaynardWallersteinHildrethClever NNEREL. Universal access to health care in America: a moral and medical imperative. Ann Intern Med. 1990;112:637-8. LinkGoogle Scholar2. . Access to health care. Ann Intern Med. 1990;112:641-61. LinkGoogle Scholar3. Marchasin S. One hospital tells the cost of regulation. The Wall Street Journal. 26 June 1990:A18. Google Scholar1. . Access to health care. Ann Intern Med. 1990;112:641-61. LinkGoogle Scholar1. . Access to health care. Ann Intern Med. 1990;112:641-61. LinkGoogle Scholar1. . Access to health care. Ann Intern Med. 1990;112:641-61. LinkGoogle Scholar2. GreenbergerDaviesMaynardWallersteinHildrethClever NNEREL. Universal access to health care in America: a moral and medical imperative. Ann Intern Med. 1990;112:637-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Marc Gourevitch, MD; Mack LipkinJr., MD; James A. Bryan, MDAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1990Volume 113, Issue 6Page: 478-480KeywordsFearHealth careHealth insurance ePublished: 1 December 2008 Issue Published: 15 September 1990 PDF downloadLoading ...
Hypoglycaemia and Golytely in Distal Intestinal Obstruction Syndrome
Authors: Arvind Shah, Su Madge, Robert Dinwiddie, Parviz Habibi
Journal: Journal of the Royal Society of Medicine (1994)

immunosuppression. Meshing the dermis allows a larger surface area to be grafted and allows simultaneous grafting with cultured keratinocytes. Unfortunately, the demand for cadaver skin greatly outstrips supply and there is a need for a connective tissue component (dermal substitute) that can be produced in the laboratory. Various techniques have been tried leading to the formation of a number of composite skin grafts or 'artificial skin substitutes'. Collagen gels contracted by incorporation of fibroblasts have had keratinocytes cultured on the surface to form a composite culture graft4 and a combination of bovine collagen and shark chondroitin-6sulphate has been overlaid with sheets of Silastic in an attempt to produce a stable skin substitute5. In fact, a number of complex culture systems exist, containing substrates of human, rat or bovine collagen some cross linked with glycoproteins and others containing fibroblasts. Unfortunately, many groups have reported poor handling with these systems6 and dermo-epidermal separation remains a problem. Certainly, at present, intact whole dermis appears to be the best substrate available. References 1 Rheinwald JG, Green H. Serial cultivation of strains of human keratinocytes: the formation in keratinising colonies from single cells. Cell 1975;6:331-44 2 Leigh IM, Navsaria H, Purkis PE, McKay I. Clinical Practice and Biological Effects of Keratinocyte Grafting. Ann Acad Med Singapore 1991;20(4):549-55 3 Leigh IM, Purkis PE, Navsaria H, Phillips TA. Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes. Br J Dermatol 1987;117:591-7 4 Bell E, Sher S, Hull B, Merrill C, Rosen S, Chamsen A, et al. The reconstruction of living skin. J Invest Dermatol 1983;81:2s-lOs 5 Burke JF, Yannas IV, Quinby WC, Bondoc CC, Jung WK. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg 1981; 194:413-28 6 Nanchahal J, Davies D. Cultured composite skin grafts for burns. BMJ 1990;301:1342-3
Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats
Authors: Danai Riga, Ioannis Kramvis, Maija K. Koskinen, Pieter van Bokhoven, Johanneke E. van der Harst, Tim S. Heistek, A. Jaap Timmerman, Pim van Nierop, Roel C. van der Schors, Anton W. Pieneman, Anouk de Weger, Yvar van Mourik, Anton N. M. Schoffelmeer, Huib D. Mansvelder, Rhiannon M. Meredith, Witte J. G. Hoogendijk, August B. Smit, Sabine Spijker
Journal: Science Translational Medicine (2017)

Alterations in the hippocampal extracellular matrix contribute to cognitive deficits in rats exhibiting a chronic depressive-like state after exposure to social defeat–induced persistent stress.