tbuckley/cabot-search huggingface dataset:
Barriers to online patient portal adoption among adult oncology patients.
Authors: Craig Siegel, Ammara Gill, Naseem Esteghamat, Yifan Tu, Miriam B. Rodin
Journal: Journal of Clinical Oncology (2017)

44 Background: Recent research shows tele-health and remote access technology enhances patient-provider communication. Among oncology patients, studies demonstrate that electronic access promotes improved treatment adherence and symptom management and provides better continuity of care and patient satisfaction. In a previous audit, we found only 26% of our oncology patients had activated our EHR (EPIC) online patient portal. MyChart facilitates communication by allowing patients to see results and email providers through a secure network. We undertook this study to discover patient opinions about MyChart and barriers to wider adoption. Methods: A short, self-administered questionnaire was distributed to a convenience sample of patients in waiting areas or the infusion center of the outpatient oncology clinic. Results: 76/108 patients knew of MyChart; 32 did not. 54/76 (71.1%) of patients who knew of MyChart had used it. 81.5% of 54 users were very or somewhat satisfied with it. Users rated features of MyChart on a 5 point scale: certain their confidentiality is protected 4.7,ability to track tests 4.4,receiving faster answers 3.0,and ease of contacting providers 2.8. 21 non-users gave several reasons for not using MyChart: preference to speak with a live person 38.1%, discomfort with the internet 23.8%, not having internet 19.0%, concern about personal information on the internet 14.3%, and too complicated 9.5%. Among 32patients not previously aware of MyChart, 43.7% said they would definitely or probably start using it.56.3% thought MyChart would make it easier to contact providers and 53.1%cited convenience over telephone.However, 28.1%,preferred speaking to a live person; 12.5% were uncomfortable with the internet, and 9.4% expressed concern with their information on the internet. Conclusions: In this sample, 50% of respondents used MyChart. Patients using MyChart were generally satisfied, specifically with confidentiality and ability to monitor their care. Barriers to increased use included a desire to speak directly to providers and lack of internet skill or access. While those using MyChart were confident that it was secure and confidential, those not using expressed concern about this issue.
Abstract 17430: Abnormal Excitation-contraction Coupling Gain in Heart Failure With Preserved Ejection Fraction (HFPEF) Can be Rescued by Cardiosphere-derived Stem Cells
Authors: Rui Zhang, Xin Yue, Ying Fu, Romain Gallet, Eduardo Marban, Robin Shaw, TingTing Hong, Joshua I Goldhaber
Journal: Circulation (2016)

Heart failure with preserved ejection fraction (HFPEF) is a major public health problem refractory to conventional therapy. Previously-studied models of HFPEF were often unverified hemodynamically, leading to confusing results. Recently, Gallet  et al  ( JACC BTS , 2016) showed that a phenotype-verified model of HFPEF, the Dahl Salt-sensitive (DS) rat fed high salt, can be rescued by cardiosphere-derived cells (CDCs). We used the same model to test the hypothesis that excitation-contraction (EC) coupling gain is decreased in HFPEF and restored by CDCs. We recorded membrane current and simultaneous intracellular calcium (Ca) dynamics in enzymatically-isolated patch clamped ventricular myocytes from control, HFPEF and CDC-treated HFPEF rats. Voltage protocols and solutions were designed to isolate L-type Ca current. We used the fluorescent Ca indicator fluo-4 AM (10 μM) and a Leica SP5 laser scanning confocal microscope to record Ca and cell shortening. All recordings were preceded by prepulses to achieve steady-state sarcoplasmic reticulum (SR) load. We found that the L-type Ca current amplitude (normalized for capacitance) was unchanged in HFPEF. However, the corresponding Ca transient amplitude was significantly decreased (by 22%, P 90  1.7x, P et al . The changes in EC coupling gain may be explained in part by disruption of the EC coupling microdomain associated with loss of the t-tubule protein cBIN1 (cardiac isoform of bridging integrator 1) and reduced local expression of Ca v 1.2 and RyR, changes that are rescued by CDCs. We conclude that 1) reduced EC coupling gain and increased myofilament Ca responsiveness are prominent features of the cellular defects in myocytes isolated from phenotype-verified HFPEF, and 2) CDCs are an effective means for reversing these changes, consistent with their hemodynamic benefit in this model.
Association between the 2012 Health and Social Care Act and specialist visits and hospitalisations in England: A controlled interrupted time series analysis
Authors: James A. Lopez Bernal, Christine Y. Lu, Antonio Gasparrini, Steven Cummins, J. Frank Wharham, Steven B. Soumerai
Journal: PLoS Medicine (2017)

Background The 2012 Health and Social Care Act (HSCA) in England led to among the largest healthcare reforms in the history of the National Health Service (NHS). It gave control of £67 billion of the NHS budget for secondary care to general practitioner (GP) led Clinical Commissioning Groups (CCGs). An expected outcome was that patient care would shift away from expensive hospital and specialist settings, towards less expensive community-based models. However, there is little evidence for the effectiveness of this approach. In this study, we aimed to assess the association between the NHS reforms and hospital admissions and outpatient specialist visits. Methods and findings We conducted a controlled interrupted time series analysis to examine rates of outpatient specialist visits and inpatient hospitalisations before and after the implementation of the HSCA. We used national routine hospital administrative data (Hospital Episode Statistics) on all NHS outpatient specialist visits and inpatient hospital admissions in England between 2007 and 2015 (with a mean of 26.8 million new outpatient visits and 14.9 million inpatient admissions per year). As a control series, we used equivalent data on hospital attendances in Scotland. Primary outcomes were: total, elective, and emergency hospitalisations, and total and GP-referred specialist visits. Both countries had stable trends in all outcomes at baseline. In England, after the policy, there was a 1.1% (95% CI 0.7%–1.5%; p < 0.001) increase in total specialist visits per quarter and a 1.6% increase in GP-referred specialist visits (95% CI 1.2%–2.0%; p < 0.001) per quarter, equivalent to 12.7% (647,000 over the 5,105,000 expected) and 19.1% (507,000 over the 2,658,000 expected) more visits per quarter by the end of 2015, respectively. In Scotland, there was no change in specialist visits. Neither country experienced a change in trends in hospitalisations: change in slope for total, elective, and emergency hospitalisations were −0.2% (95% CI −0.6%–0.2%; p = 0.257), −0.2% (95% CI −0.6%–0.1%; p = 0.235), and 0.0% (95% CI −0.5%–0.4%; p = 0.866) per quarter in England. We are unable to exclude confounding due to other events occurring around the time of the policy. However, we limited the likelihood of such confounding by including relevant control series, in which no changes were seen. Conclusions Our findings suggest that giving control of healthcare budgets to GP-led CCGs was not associated with a reduction in overall hospitalisations and was associated with an increase in specialist visits.
USP1–UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses
Authors: Zhongxia Yu, Hui Song, Mutian Jia, Jintao Zhang, Wenwen Wang, Qi Li, Lining Zhang, Wei Zhao
Journal: The Journal of Experimental Medicine (2017)

Optimal activation of TANK-binding kinase 1 (TBK1) is crucial for initiation of innate antiviral immunity and maintenance of immune homeostasis. Although several E3 ubiquitin ligases have been reported to regulate TBK1 activation by mediating its polyubiquitination, the functions of deubiquitinase on TBK1 activity remain largely unclear. Here, we identified a deubiquitinase complex, which is formed by ubiquitin specific peptidase 1 (USP1) and USP1-associated factor 1 (UAF1), as a viral infection–induced physiological enhancer of TBK1 expression. USP1–UAF1 complex enhanced TLR3/4 and RIG-I–induced IFN regulatory factor 3 (IRF3) activation and subsequent IFN-β secretion. Mechanistically, USP1 and UAF1 bound to TBK1, removed its K48-linked polyubiquitination, and then reversed the degradation process of TBK1. Furthermore, we found that ML323, a specific USP1–UAF1 inhibitor, attenuated IFN-β expression and enhanced viral replication both in vitro and in vivo. Therefore, our results outline a novel mechanism for the control of TBK1 activity and suggest USP1–UAF1 complex as a potential target for the prevention of viral diseases.
Prospects for passive immunity to prevent HIV infection
Authors: Lynn Morris, Nonhlanhla N. Mkhize
Journal: PLoS Medicine (2017)

The need for better HIV prevention toolsDespite the widespread global rollout of antiretroviral therapy and its ability to reduce onward HIV transmission, an alarming 1.8 million new HIV infections are estimated to have occurred in 2016 [1].Effective methods to prevent HIV infection include condom use and pre-exposure prophylaxis (PrEP) with antiretroviral drugs; however, owing to barriers such as adherence, an effective vaccine would be the most definitive solution to the ongoing burden of HIV infection.Yet researchers have struggled to design a prophylactic vaccine able to induce protective immunity.This highlights the urgency of developing new tools to prevent HIV infections and achieve control of the global epidemic [2].One such approach is passive immunization with protective antibodies, a strategy that has been used against infectious diseases for over 100 years and has proven useful for post-exposure prophylaxis or against pathogens where no vaccines yet exist [3].The flourishing field of antibody therapeutics, together with the identification of a growing number of broad and potent HIV monoclonal antibodies, presents an extraordinary opportunity to use this approach for HIV prevention.The protective and therapeutic effects of a number of these broadly neutralizing antibodies (bNAbs) have been well demonstrated in animal studies [4].Furthermore, bNAbs have been shown to have modest antiviral effects in HIV-infected humans, both in reducing viremia and delaying viral rebound after interruption of antiretroviral treatment [5][6][7].What is not yet known is whether bNAbs are able to protect uninfected humans from acquiring HIV.
Imminent Death Liver Donation for Children
Authors: Ruth L. Ackah, Abbas Rana, John A. Goss
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Abstract 17670: Mechanical Circulatory Support for Cardiovascular Shock: Results From the Japanese Circulation Society Cardiovascular Shock Registry
Authors: Yasushi Ueki, Hiroshi Imamura, Takahiro Miyamoto, Tsukasa Yagi, Kazuo Sakamoto, Hiroshi Takahashi, Hiroyuki Hanada, Naohiro Yonemoto, Eizo Tachibana, Ken Nagao
Journal: Circulation (2016)

Introduction:  Mechanical circulatory support (MCS) such as intra-aortic balloon pump (IABP) and extracorporeal membrane oxygenation (ECMO) are widely used for patients with profound or refractory cardiovascular shock. However, little is known about outcome of cardiovascular shock patients undergoing MCS.   Methods:  A total of 979 patients with cardiovascular shock were enrolled from the Japanese Circulation Society Cardiovascular Shock registry, which is a prospective, observational, multi-center, cohort study conducted from May 2012 to June 2014. Of those, 704 patients who had not experienced out-of-hospital cardiac arrest, including 160 patients undergoing IABP (IABP group), 17 undergoing ECMO (ECMO group), 61 undergoing ECMO and IABP (ECMO+IABP group), and 466 not undergoing MCS (non-MCS group), were included in this study. The primary endpoint was all-cause mortality at 30 days.   Results:  The systolic blood pressure on hospital arrival was significantly different among four groups (79.2±15.5 mmHg in the non-MCS group, 77.5±15.0 mmHg in the IABP group, 69.8±17.6 mmHg in the ECMO group, 74.5±13.6 mmHg in the ECMO+IABP group, p=0.029). The 30-day mortality was higher in both ECMO groups than other groups (20.0 % in the non-MCS group, 27.5% in the IABP group, 58.8% in the ECMO group, 60.7% in the ECMO+IABP group, p   Conclusions:  Although there was insufficient evidence to support or refute the use of MCS in patients with cardiovascular shock, the use of IABP did not significantly reduce 30-day mortality. Furthermore, the use of ECMO had poor outcome despite the use of IABP.
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo
Authors: Daniel J. Apicco, Peter E. A. Ash, Brandon Maziuk, Chelsey LeBlang, Maria Medalla, Ali Al Abdullatif, Antonio Ferragud, Emily Botelho, Heather I. Ballance, Uma Dhawan, Samantha Boudeau, Anna Lourdes Cruz, Daniel Kashy, Aria Wong, Lisa R. Goldberg, Neema Yazdani, Cheng Zhang, Choong Y. Ung, Yorghos Tripodis, Nicholas M. Kanaan, Tsuneya Ikezu, Pietro Cottone, John Leszyk, Hu Li, Jennifer Luebke, Camron D. Bryant, Benjamin Wolozin
Journal: Nature Neuroscience (2017)
Situation analysis of colorectal cancer status in Uzbekistan and implementing measures to increase early detection and survival rate
Authors: Y.V. Ten, S.B. Abdujapparov, H.D. Islamov, D.M. Egamberdiev, Y. Ziyaev, S.Y. Matniyazova, H.B. Bobokulov, B.S. Korahojaev, S.M. Djanklich, A.S. Abdujapparov
Journal: Annals of Oncology (2017)
Rotavirus en Irlanda
Authors: B Cryan, M Lynch, D Whyte
Journal: Eurosurveillance (1997)

La diarrhee aigue est la cause la plus courante de morbidite et de mortalite a travers le monde. La diarrhee infectieuse est estimee etre responsable d'au moins 5 millions de deces chaque annee dans les pays en voie de developpement (1). Les tres jeunes enfants sont particulierement susceptibles a l'infection et, chez eux, la mortalite est la plus importante. Le rotavirus est l'entero-pathogene le plus repandu chez les enfants a la fois dans les pays developpes et les pays en voie de developpement (1). La particularite frappante de l'infection a rotavirus dans les pays temperes est sa saisonnalite. Contrairement aux autres entero-pathogenes qui circulent surtout pendant les mois chauds, la “saison” du rotavirus se situe en hiver et au printemps. Habituellement, ce sont les enfants de moins de 2 ans qui sont affectes ; le rotavirus peut etre responsable de plus de 50% des admissions dans les unites pediatriques durant les mois d'hiver (2).
The endoscopic loop-and-let-go technique for treatment of an exceedingly rare cause of recurrent biliary pain
Authors: Joana Carmo, José Rodrigues, Júlio Veloso, Vitor Duarte, Ricardo Gorjão, Eduardo Barroso
Journal: Endoscopy (2017)

A 67-year-old Caucasian male was admitted to another institution with choledocholithiasis complicated by acute cholangitis. Endoscopic retrograde cholangiopancreatography (ERCP) showed a large duodenal subepithelial lesion fully covering the papilla, and a dilated common bile duct (CBD) with multiple filling defects. Sphincterotomy was performed and CBD stones were removed. The patient underwent laparoscopic cholecystectomy 2 weeks later.
Distancing, not embracing, the Distancing-Embracing model of art reception
Authors: Stephen Davies
Journal: Behavioral and Brain Sciences (2017)

Abstract Despite denials in the target article, the Distancing-Embracing model appeals to compensatory ideas in explaining the appeal of artworks that elicit negative affect. The model also appeals to the deflationary effects of psychological distancing. Having pointed to the famous rejection in the 1960s of the view that aesthetic experience involves psychological distancing, I suggest that “distance” functions here as a weak metaphor that cannot sustain the explanatory burden the theory demands of it.
Comparative pharmacokinetics of a proposed biosimilar bevacizumab Bmab-100 and reference product bevacizumab in a multicentre double blind randomized clinical trial in metastatic colorectal carcinoma (mCRC) patients
Authors: S. Beniwal, M. Kothekar, S. Loganathan, A. Vishweswaramurthy, A. Marwah, E. Pennella, N. Sengupta
Journal: Annals of Oncology (2017)
Former USA Gymnastics team doctor pleads guilty to sexual assault
Authors: Owen Dyer
Journal: BMJ (2017)

A once renowned sports medicine specialist accused of molesting at least 125 girls and women while he worked for USA Gymnastics and for Michigan State University has pleaded guilty to multiple charges of sexual assault and will face at least 25 years in prison.

Larry Nassar, 54, a father of three, admitted to digitally penetrating seven girls while pretending to treat their injuries at his home in Lansing, Michigan and at a campus clinic from 1998 to …
Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies
Authors: Julie Dyall, Robin Gross, Jason Kindrachuk, Reed F. Johnson, Gene G. Olinger, Lisa E. Hensley, Matthew B. Frieman, Peter B. Jahrling
Journal: Drugs (2017)

No specific antivirals are currently available for two emerging infectious diseases, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). A literature search was performed covering pathogenesis, clinical features and therapeutics, clinically developed drugs for repurposing and novel drug targets. This review presents current knowledge on the epidemiology, pathogenesis and clinical features of the SARS and MERS coronaviruses. The rationale for and outcomes with treatments used for SARS and MERS is discussed. The main focus of the review is on drug development and the potential that drugs approved for other indications provide for repurposing. The drugs we discuss belong to a wide range of different drug classes, such as cancer therapeutics, antipsychotics, and antimalarials. In addition to their activity against MERS and SARS coronaviruses, many of these approved drugs have broad-spectrum potential and have already been in clinical use for treating other viral infections. A wealth of knowledge is available for these drugs. However, the information in this review is not meant to guide clinical decisions, and any therapeutic described here should only be used in context of a clinical trial. Potential targets for novel antivirals and antibodies are discussed as well as lessons learned from treatment development for other RNA viruses. The article concludes with a discussion of the gaps in our knowledge and areas for future research on emerging coronaviruses.
Models of care for serious illness: What is the evidence?
Authors: Robin L. Whitney, Janice Bell, Khue Nguyen, Theresa Schmidt, Sibel Ozcelik, Cynthia Matsumoto
Journal: Journal of Clinical Oncology (2017)

168 Background: Individuals with cancer and other serious illness may benefit from specialized models of care, including palliative care. However, limited evidence exists to guide real-world implementation of such programs. We reviewed evidence supporting models of care for serious illness as part of a larger effort to develop an implementation framework for serious illness care programs. Methods: We conducted a systematic review, focusing on existing reviews and meta-analyses across a broad range of serious illness population definitions and programs. The quality of evidence was graded and results were synthesized with respect to five outcomes categories (patient and caregiver experience; care and support processes; health outcomes; health service use and costs; and operations), program components associated with success, and implementation considerations. Results: Collectively, 28 reviews were identified, reporting 743 studies, 426 of which were randomized controlled trials. The strongest and most consistent evidence was for reduced health service use and costs (e.g., reduced hospitalization and emergency department use) and for improved patient and caregiver experiences. Few reviews reported on operational outcomes. Program components most frequently reported as associated with success included targeted selection of high-risk patients; face-to-face contact; and transition management. Common recommendations for implementation (reported in 10 of 28 reviews) included attention to relationship building, inclusion of technology-enabled decision support and continuous quality improvement. Conclusions: Compelling evidence exists for improved outcomes across a range of serious illness care models and populations with palliative care needs. Policy attention to payment structures that support feasibility and sustainability of these care models is warranted. Future research might address gaps in the literature, including implementation-related factors, operational outcomes and the relative contribution of individual components associated with program success.
Setting the empirical record straight: Acceptability judgments appear to be reliable, robust, and replicable
Authors: Jon Sprouse, Diogo Almeida
Journal: Behavioral and Brain Sciences (2017)

Abstract Branigan &amp; Pickering (B&amp;P) advocate the use of syntactic priming to investigate linguistic representations and argue that it overcomes several purported deficiencies of acceptability judgments. While we recognize the merit of drawing attention to a potentially underexplored experimental methodology in language science, we do not believe that the empirical evidence supports B&amp;P's claims about acceptability judgments. We present the relevant evidence.