tbuckley/cabot-search huggingface dataset:
COMPLETE ENDOSCOPIC MUCOSAL RESECTION OF MALIGNANT COLONIC SESSILE POLYPS AND CLINICAL OUTCOME OF 51 CASES
Authors: M Fragaki, E Voudoukis, E Chliara, I Dimas, A Mpitouli, E Vardas, A Theodoropoulou, K Karmiris, L Giannikaki, G Paspatis
Journal: Endoscopy (2018)

Meta-analyses and guidelines recommend that deep submucosal invasion (> 1 mm) in malignant colonic polyps is an important risk factor for residual malignant disease. However, the existing data are based on small retrospective studies with marked heterogeneity. The aim of this study is to test the correlation between the submucosal invasion depth and the rate of residual malignant disease in complete endoscopic mucosal resection (EMR) of malignant colonic sessile polyps. The secondary outcomes include risk factors such as: lymphovascular invasion, tumor differentiation, resection margin status and the presence of tumor budding.
IS HIGH-PRESSURE INJECTION USEFUL FOR ENDOSCOPIC SUBMUCOSAL DISSECTION? RESULTS OF A RANDOMIZED PROSPECTIVE STUDY COMPARING TWO “SECOND-GENERATION” KNIVES IN A PORCINE MODEL
Authors: N Musquer, N Chapelle, M Le Rhun, E Metivier-Cesbron, Y Touchefeu, E Coron
Journal: Endoscopy (2018)

to compare, in terms of efficacy and safety, two second-generation knives with high- or low-pressure injection of fluid.
DOES POLYETHYLENE GLYCOL CLEANSING PURGE IMPROVE VIDEO CAPSULE ENDOSCOPY DIAGNOSTIC YIELD IN OBSCURE GASTROINTESTINAL BLEEDING?
Authors: F Cholet, G Rahmi, M Gaudric, J Filippi, C Duburque, S Bramli, V Quentin, Z Alavi, A Dion, JC Saurin, M Robaszkiewicz, C Cellier
Journal: Endoscopy (2018)

Small-bowel cleansing is required prior video capsule endoscopy (VCE). Nevertheless, there is no consensus on the type, volume and regimen of cleansing purge. Moreover, guidelines recommend polyethylene glycol (PEG) but are 1C GRADE (low quality evidence). Randomized, multicenter, prospective studies are still required. Our study aimed to compare the frequency of diagnosis of at least one lesion: high bleeding potential (P2) or intermediate bleeding potential (P1) of small bowel in patients with gastrointestinal bleeding (OGIB) undergoing VCE using different cleansing regimens.
Eribulin (E) and capecitabine (C), a combined treatment schedule in elderly metastatic breast cancer (EMBC): Efficacy and safety evaluation (E&amp;S).
Authors: Ignazio Ugo Carreca, Paolo D'alia, Giuseppe Bronte, Viviana Bazan, Dario Cova, Paolo Foa, Antonio Russo
Journal: Journal of Clinical Oncology (2014)

e20513 Background: E mesylate, a nontaxane microtubule dynamics inhibitor, was approved in the U.S in 2010 for the treatment of MBC who have previously received at least 2 MBC chemo regimens, including anthracycline and taxanes (A&T). Aim: We know that E is administered as a single iv agent at dose of 1.4 mg/sqm d1-8 every 21 with moderate general toxicity. Since elderly patients develop rapid and sometime fatal toxicity during treatment with traditional regimens, we plain to design a new schedule (E+C), more safe and effective, in EMBC pts pre-treated with A&T regimens and with up to two points on Charlson’s Score Comorbidity. Methods: 30 EMBC pts mean age 77 ( range 70–85 ) with one site of visceral metastases were enrolled in this study. Pts were treated with C 900 mg/sqm bid on d1-14 every 21d and E 0.98 mg/sqm IV on d1-8 every 21d (Dose-adjustement according to Kintzel-Dorr’s formula for Elderly Pts).Comprehensive Geriatric Assessment (CGA) was performed before, to assess eligibility for chemotherapy and after treatment to evaluate clinical benefit (CB) and clinical response rates (CRR) according to WHO criteria. Toxicity profile using NCI-CTC v2.0 and Quality of life (QoL) score through EORTC QLQ-C30 questionnaires were also considered. Adequate renal, bone-marrow and liver function were required to enrolling patients.Written informed-consent was acquired. Results: A total number of 120 cycles were delivered without evident toxicity for all pts enrolled. Treatment is still prolonged until intolerable toxicity or disease progression. None of the pts needed any delay in drugs-delivery. No grade-4 toxicity was experienced. QoL score improvement was noted in all pts after treatment. Total CB+CRR was about 78%. Conclusions: Preliminary analisys of these data have demonstrated that the proposed schedule to treat EMBCpts with comorbidity or frailty is E&S more than traditional regimens for MBC. Pts are still monitored for possible long-term toxicity, QoL empairment and CRR. To confirm this a larger number of pts are under evaluation for enrolling in the study.
Fully automatic detection and segmentation of abdominal aortic thrombus in post-operative CTA images using Deep Convolutional Neural Networks
Authors: Karen López-Linares, Nerea Aranjuelo, Luis Kabongo, Gregory Maclair, Nerea Lete, Mario Ceresa, Ainhoa García-Familiar, Iván Macía, Miguel A. González Ballester
Journal: Medical Image Analysis (2018)
HIGHER MEAN HAREFIELD CLEANSING SCALE SCORES WITH 1L PEG-BASED NER1006 VERSUS 2L PEG + ASCORBATE: POST HOC ANALYSIS OF A RANDOMISED PHASE 3 CLINICAL TRIAL
Authors: R Bisschops, J Manning, L Clayton, B Amlani, M Álvarez-González
Journal: Endoscopy (2018)

The cleansing efficacy and safety of NER1006 (PLENVU®), a novel 1L polyethylene glycol (PEG)-based bowel preparation, were assessed versus standard 2L PEG + Ascorbate in the randomised phase 3 clinical trial MORA. This post hoc analysis of MORA assessed cleansing efficacy as the mean segmental cleansing scores using the Harefield Cleansing Scale (HCS).
Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis
Authors: Marit Westerterp, Panagiotis Fotakis, Mireille Ouimet, Andrea E. Bochem, Hanrui Zhang, Matthew M. Molusky, Wei Wang, Sandra Abramowicz, Sacha la Bastide-van Gemert, Nan Wang, Carrie L. Welch, Muredach P. Reilly, Erik S. Stroes, Kathryn J. Moore, Alan R. Tall
Journal: Circulation (2018)

The CANTOS trial (Canakinumab Antiinflammatory Thrombosis Outcome Study) showed that antagonism of interleukin (IL)-1β reduces coronary heart disease in patients with a previous myocardial infarction and evidence of systemic inflammation, indicating that pathways required for IL-1β secretion increase cardiovascular risk. IL-1β and IL-18 are produced via the NLRP3 inflammasome in myeloid cells in response to cholesterol accumulation, but mechanisms linking NLRP3 inflammasome activation to atherogenesis are unclear. The cholesterol transporters ATP binding cassette A1 and G1 (ABCA1/G1) mediate cholesterol efflux to high-density lipoprotein, and Abca1/g1 deficiency in myeloid cells leads to cholesterol accumulation.
Vidéo-capsule colique électronique: évaluation d'un protocole de préparation colique modifié (POIT20) et de sa faisabilité en pratique quotidienne
Authors: JC Letard, P Adenis Lamarre, P Georget, F Martin
Journal: Endoscopy (2009)

Introduction: La vidéo capsule colique électronique (VCCE) est un dispositif médical qui permet l'étude du côlon (hors dépistage ciblé du CCR). La qualité de la préparation colique est déterminante pour réaliser cet examen, nous souhaitions évaluer: l'efficacité du protocole de préparation POIT20; ainsi que la faisabilité de cette nouvelle technique.
The expression of pAKT/survivin and their role in colorectal cancer.
Authors: Junjie Gu, Zhao Sun, Chunmei Bai, Fei Luo
Journal: Journal of Clinical Oncology (2018)

595 Background: Colorectal cancer(CRC) is the fourth most prevalent cancer and the leading cause of cancer mortality worldwide. Drug resistance remains the main obstacle to the success of cytotoxic therapies. It is reported that soluble factors released by carcinoma-associated fibroblasts(CAFs) can induce the translocation of AKT, Survivin, P38 to the nucleus of tumor cells, which might be the mechanism of microenvironment-mediated drug resistance to nonspecific conventional chemotherapeutic agents, such as platinum compounds or 5-FU. Methods: Clinicopathological data of colorectal cancer patients who underwent chemotherapy (XELOX or FOLFOX) were collected, followed up and evaluated. p-AKT and survivin expression were assessed by immunohistochemical (IHC) staining. The relationships between p-AKT and survivin expression and patients’ resistance to chemotherapy were analyzed by Chi square respectively. The expression between p-AKT and survivin expression and progression-free survival(PFS) of patients were analyzed by Kaplan-Meier. Results: 51 CRC patients were enrolled in our research. Among them, 21 patients were resistant to chemotherapy(PD), and 30 patients were sensitive to chemotherapy(PR). P-AKT and survivin were assessed by IHC in 47 patients. Among them, 17 patients were p-AKT positive, and 29 patients were survivin positive. Patients of progressive disease(resistant to chemotherapy) were significantly associated with p-AKT positive and survivin positive(p = 0.009, 0.000). Poorer progression-free survival(PFS) was observed in patients with survivin positive compared to those with survivin negative(6.323±0.9m, 13.857±2.664m, Breslow chi square = 4.885, p value = 0.027). There is no significant difference between p-AKT expression and PFS(Breslow chi square = 2.403, p value = 0.121). Conclusions: CRC patients with p-AKT positive or survivin positive were more likely to be resistant to chemotherapeutic agents. CRC patients with survivin positive had a shorter DFS.
A healthy diet in women is associated with less facial wrinkles in a large Dutch population-based cohort
Authors: Selma Mekić, Leonie C. Jacobs, Merel A. Hamer, M. Arfan Ikram, Josje D. Schoufour, David A. Gunn, Jessica C. Kiefte-de Jong, Tamar Nijsten
Journal: Journal of the American Academy of Dermatology (2018)
LUMEN-APPOSING FULLY-COVERED SELF-EXPANDABLE METAL STENTS VERSUS BILIARY FULLY-COVERED SELF-EXPANDABLE METAL STENTS FOR EUS-GUIDED DRAINAGE OF PANCREATIC FLUID COLLECTIONS: WHICH METAL STENT SHOULD BE USED?
Authors: E Vázquez Sequeiros, AG García de Paredes, JR Foruny Olcina, J Ángel González Martín, F Gonzalez Panizo, D Juzgado, A Albillos Martínez
Journal: Endoscopy (2018)

EUS-guided drainage has become first line treatment of encapsulated pancreatic fluid collections (PFC). It is not well established which stent should be used.
Intratumoral CpG-B Promotes Antitumoral Neutrophil, cDC, and T-cell Cooperation without Reprograming Tolerogenic pDC
Authors: Marion Humbert, Leslie Guery, Dale Brighouse, Sylvain Lemeille, Stephanie Hugues
Journal: Cancer Research (2018)

Cancer immunotherapies utilize distinct mechanisms to harness the power of the immune system to eradicate cancer cells. Therapeutic vaccines, aimed at inducing active immune responses against an existing cancer, are highly dependent on the immunological microenvironment, where many immune cell types display high levels of plasticity and, depending on the context, promote very different immunologic outcomes. Among them, plasmacytoid dendritic cells (pDC), known to be highly immunogenic upon inflammation, are maintained in a tolerogenic state by the tumor microenvironment. Here, we report that intratumoral (i.t.) injection of established solid tumors with CpG oligonucleotides-B (CpG-B) inhibits tumor growth. Interestingly, control of tumor growth was independent of tumor-associated pDC, which remained refractory to CpG-B stimulation and whose depletion did not alter the efficacy of the treatment. Instead, tumor growth inhibition subsequent to i.t. CpG-B injection depended on the recruitment of neutrophils into the milieu, resulting in the activation of conventional dendritic cells, subsequent increased antitumor T-cell priming in draining lymph nodes, and enhanced effector T-cell infiltration in the tumor microenvironment. These results reinforce the concept that i.t. delivery of TLR9 agonists alters the tumor microenvironment by improving the antitumor activity of both innate and adaptive immune cells.Significance: Intratumoral delivery of CpG-B disrupts the tolerogenic tumor microenvironment and inhibits tumor growth. Cancer Res; 78(12); 3280-92. ©2018 AACR.
Talking to others: The importance of responsibility attributions by observers
Authors: Stefanie Hechler, Thomas Kessler
Journal: Behavioral and Brain Sciences (2018)

Abstract This commentary extends Doris's approach of agency by highlighting the importance of responsibility attributions by observers. We argue that (a) social groups determine which standards are relevant and which actors are responsible, (b) consensus about these attributions may correct individual defeaters, and (c) the attribution of moral responsibility reveals agency of observers and may foster the actors' agency.
ENDOSCOPIC MANAGEMENT OF UNCONTROLLED FUNGAL INFECTION IN A CASE OF PERIPANCREATIC COLLECTION. ANTIFUNGAL INTRACAVITARY INFUSION AS AN ALTERNATIVE TREATMENT
Authors: D Collado Pacheco, C Garcia-Ramos Garcia, JL Castro Urda, P Castro Carbajo, M Perez, M Lomberas, L Ramon Rabago Torre
Journal: Endoscopy (2018)

We present a case of peripancreatic collection with persistent fungal infection despite of drainage of the peripancreatic collection with the Hot-Axios® device. We describe a new successful treatment approach not previously reported so far for the management of the fungal infection.
Why value values?
Authors: Samuel Murray
Journal: Behavioral and Brain Sciences (2018)

Doris argues that an agent is responsible for her behavior only if that behavior expresses (a relevant subset of) the agent's values. This view has problems explaining responsibility for mistakes or episodes of forgetfulness. These problems highlight a conceptual problem with Doris's theory of responsible agency and give us reasons to prefer an alternative (non-valuational) theory of responsible agency.
Microbiota as a new indicator of colorectal cancer (CRC) heterogeneity.
Authors: Iradj Sobhani, Amine Ghozelane, Emma Bergsten Bergsten, Sean Kennedy
Journal: Journal of Clinical Oncology (2017)

3615 Background: Location and somatic gene signature of CRCs may impact prognosis and therapy response. The aim was to characterize colon Microbiota in CRC patients regarding location, gene markers and outcome. Methods: Patients (N = 173) signed consent for whole metagenome (shot gun sequencing on Illumina HiSeq2500) analysis of stool DNA: 72 CRC (53 sporadic-S, 19 Lynch-L), 87 asymptomatic subjects (normal colonoscopy), 14 first degree healthy relatives from Lynch families. "MOCAT" pipeline was used, library sorted (Phred quality score ¡20 Alientrimmer v0.4.0) after exclusion of &lt; 35 nt, human genes or phage sequences. Quality sequences were aligned (REFMG.V13) and most abundant genes constructed (MBMA program v0.1). The Shaman program (shaman.c3bi.pasteur.fr) was used. The number of bacteria was estimated (REFMG program). The linear model (GLM) was implemented in the DESeq2 R kit. Dfferences between Control (N = 87) and CRCs (N = 69), between L (N = 19) and S CRCs(N = 50), and between LCRC (N = 19) and Healthy Lynch relatives were obtained after interaction of age, BMI and gender was considered (GLM model). The P &lt; 0.1 value was retained after correction (Benjamini and Hochberg). The specific taxonomic composition of the control and CRC groups was subjected to random analysis ( Caret's R package) with two optimization parameters (precision and kappa) in the model. Results: There was no difference for gender, age (p = 0.08) and BMI (p = 0.187) in the L and S CRCs. Significant differences were observed between Normal and CRCs, C-CRC and L-CRC, L-CRC and first degree relatives based on the common component (similarity of sequences): 13 species differentiated Normal and CCRs, two were more prevalent in L-CRCs. The panels of bacteria linked with location, MSI, Ras mutations, methylation phenotypes and survival were identified. No significant link was observed with TNM Staging: I (N = 17, 2L and 15S), II (N = 12, 5L and 7S), III (N = 20, 10L, 10S), IV (N = 22.1L, 21S). DFS might be dysbiosis dependent. Conclusions: CRC dysbiosis is location-dependent. Several bacteria are associated with Ras mutation, MSI, and methylation status. They may directly or through therapies impact the prognosis. Microbiota signature should be taken in consideration in trials.
Metal Nanoparticles for Diagnosis and Therapy of Bacterial Infection
Authors: Peiyan Yuan, Xin Ding, Yi Yan Yang, Qing‐Hua Xu
Journal: Advanced Healthcare Materials (2018)

Infectious diseases caused by pathogenic bacteria, especially multidrug-resistant bacteria, and their global spreading have become serious public health concerns. Early diagnosis and effective therapy can efficiently prevent deterioration and further spreading of the infections. There is an urgent need for sensitive, selective, and facile diagnosis as well as therapeutically potent treatment. The emergence of nanotechnology has provided more options for diagnosis and treatments of bacterial infections. Metal nanoparticles and metal oxide nanoparticles have drawn intense attention owing to their unique optical, magnetic, and electrical properties. These versatile metal-based nanoparticles have great potential for selective detection of bacteria and/or therapy. This review gives an overview of recent efforts on developing various metal-based nanoparticles for bacterial detection and infection therapy. It begins with an introduction of fundamental concepts and mechanisms in designing diagnostic and therapeutic strategies. Representative achievements are selected to illustrate the proof-of-concept in vitro and in vivo applications. A brief discussion of challenges and perspective outlook in this field is provided at the end of this review.
FRI0150 Clinical manifestations of giant cell arteritis: changes over 20 years
Authors: KT Calamia, JR Basarich, M Schirmer, MD Cohen
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Complications of Giant Cell Arteritis (GCA) can be prevented with prompt diagnosis and treatment in most cases. However, the presenting manifestations of the disease are diverse and may be non-specific. <h3>Objectives</h3> We undertook this study in order to determine the clinical features in 100 conecutive patients with GCA. We compared these features in patients with and without visual loss. We compared the findings to those from a study of 100 consecutive biopsy proven cases from the same institution by one of the authors (KTC) 20 years earlier. <h3>Methods</h3> We reviewed the clinical records of 100 consecutive biopsy-proven cases of GCA diagnosed just prior to December 31, 1998. Findings in patients with and without visual loss were compared and findings in this series were compared to those of an identical review of 100 consecutive biopsy-proven cases from our institution, ending in December, 1978.<sup>1</sup> Differences were compared using Fisher's exact test and the rank sum test. <h3>Results</h3> In the current series, there were 77 females and 23 males, with a mean age at diagnosis of 73.2 years. The mean duration of symptoms prior to diagnosis was 3.5 months. Headache was the initial symptom in 41 patients and twenty patients presented with polymyalgia rheumatica. However, systemic symptoms dominated the clinical presentation in 22 patients and 13 patients were evaluated for fever of unknown origin. Swallowing or tongue claudication was seen in 7 patients. Trismus or dysgeusia were reported by some patients. Nine patients complained of sore throat and 10 patients had cough. Twelve patients developed loss of vision. Inflammatory parameters were not significantly different in patients with visual loss as compared to those without. The median duration of symptoms were shorter (p &lt; 0.001), median sedimentation rate was lower (p &lt; 0.001) and the median haemoglobin concentration was higher (p = 0.011) in the current series when compared to patients diagnosed 20 years earlier. <h3>Conclusion</h3> The presenting manifestations in this group of patients with GCA were diverse and often did not suggest the diagnosis. Clinical suspicion for the disease in the setting of an older patient with systemic symptoms or with a variety of head and neck symptoms, with laboratory evidence of an inflammatory process, was critical for the diagnosis. Because of this suspicion, patients were diagnosed earlier after onset of symptoms, with less prominent inflammatory findings, than they were 20 years ago. <h3>Reference</h3> Calamia KT, Hunder GG. Clinical manifestations of giant cell (temporal) arteritis. Clin Rheum Dis. 1980;6:389–403
DIABETES MELLITUS – A RISK FACTOR FOR POOR BOWEL PREPARATION?
Authors: M Ciochina, DV Balaban, IA Zoican, GC Robu, IC Enache, L Pinte, P Nuta, F Ionita, M Jinga
Journal: Endoscopy (2018)

Adequate bowel preparation is the most important prerequisite for a successful colonoscopy. Patient-related factors contribute to poor bowel preparation. Among these, diabetes mellitus (DM) could predispose to a poor bowel preparation due to inability to maintain fasting and autonomous neuropathy with consequent bowel paresis. Our aim was to assess bowel preparation in patients with DM.
Profiling of protein–protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors
Authors: Hong-Won Lee, Byoungsan Choi, Han Na Kang, Hyunwoo Kim, Ahrum Min, Minkwon Cha, Ji Young Ryu, Sangwoo Park, Jinyoung Sohn, Kihyuk Shin, Mi Ran Yun, Joo Yeun Han, Min Ju Shon, Cherlhyun Jeong, Junho Chung, Seung-Hyo Lee, Seock-Ah Im, Byoung Chul Cho, Tae-Young Yoon
Journal: Nature Biomedical Engineering (2018)
POPULATION-BASED STUDY. SCREENING FOR COLORECTAL CANCER. DIFFERENCES BETWEEN MALES AND FEMALES. RESULTS IN 73545 SUBJECTS
Authors: G Hontoria Bautista, MA Jimenez Moreno, R Pereda Garcia, J Sanz Sanchez, B Bernad Cabredo, A Moncada Urdaneta, E Badia Aranda, B Sicilia Aladren, S Garcia Moran, JL Martin Lorente, F Saez-Royuela Gonzalo
Journal: Endoscopy (2018)

To describe the findings and the differences in neoplastic findings between sexes in the asymptomatic participants.
TEMPORARY PERCUTANEOUS ENDOSCOPIC GASTROSTOMY – USEFULNESS AND FOLLOW-UP
Authors: R Micut, G Tudor, R Mateescu, MM Pruna, M Jinga, F Ionita-Radu, SN Bucurica
Journal: Endoscopy (2018)

The study's aim was to evaluate a group of patients that had percutaneous endoscopic gastrostomy (PEG) placement regarding the indications of PEG, period of usage, type of nutrition and quality of life.
EUS-guided needle-based Confocal Laser induced Endomicroscopy (nCLE): a correlation study of “through the needle' imaging with normal histology in a porcine model
Authors: K Chang
Journal: Endoscopy (2011)

Background: Endoscopic probe-based Confocal Laser Endomicroscopy (pCLE) enables in-vivo real time imaging of cells and blood flow within the mucosal layer of the GI tract. Recently, a prototype high-resolution CLE probe has been developed (Cellvizio®, Mauna Kea Technologies) which can be introduced through a 19g FNA needle creating the possibility for needle-based Confocal Laser Endomicroscopy (nCLE). The feasibility and quality of images obtained using EUS-guided nCLE in solid organs such as the pancreas, liver, spleen, gallbladder and lymph node have not been clearly correlated with normal histology.