tbuckley/cabot-search huggingface dataset:
SAT0015 Uveitis as the initial clinical manifestation in patiens with spondyloarthopathies
Authors: J Fernández-Melón, S Muñoz-Fernández, V Hidalgo, G Bonilla, A Schlincker, A Fonseca, J Vieitez, E Martin-Mola
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Uveitis can be the first manifestation in patients with spondyloarthropathy (spA). <h3>Objectives</h3> To investigate the frecuency and pattern of presentation uveitis as the first clinical manifestation in patients with spA. <h3>Methods</h3> In this study we include the patients with uveitis attended simoultaneosly by ophthalmologists and rheumatologists in our Uveitis Clinic between June 1997 and October 2000. A clinical preestablished protocol based on the pattern of uveitis and the patient´s symptoms was used to achieve diagnosis in each case. Diagnostic evaluation included, a clinical history, an ophthalmologic examination, hemogram, biochemistry, ESR, a fluorescent treponemal antibody absortion test, urinary test and a chest x-ray. In addition, in patients with previous flares of uveitis a pelvis x-ray was done. Any type of studies were ordered according to protocol. <h3>Results</h3> Date from 376 were recorded in our date base. Seventy (18.6%) had some type of spA, 49 (70% of patients with spA) were male and the mean age of this group was 44.7, SD:15.7. Forty patients (57%) were previously diagnosed (33 ankylosing spondylitis (AS), 4 Reiter´s syndrome (RS), 2 inflammatory bowel disease (EII) and 1 undifferentiated spA (UspA)); thirty (43%) were undiagnosed and uveitis was the first manifestation (15 AS, 5 psoriatic arthritis (PA), 4 RS, 4 EII, 1 UspA and 1 SAPHO). The most frequent clinical pattern was acute (only one was chronic), anterior (only two were panuveitis) and unilateral (only four were bilateral) uveitis. There were two main keys to achieve the diagnosis of spA that were the recurrence of a type of pattern of uveitis (acute, recurrent and unilateral) and the presence of lumbar or articular pain in addition to the uveitis flare. HLA B27 was found in 47 (66%) patients, 37 AS, 4 RS, 4 PA, one UspA and one SAPHO syndrome. All patients received local treatment. Sistemic corticosteroids, sulfasalazine and metotrexate was associated in 8, 8 and 1 patient respectively. <h3>Conclusion</h3> Uveitis was the first manifestation in 43% of the patients with spA, attended prospectively in a multidisciplinary outpatient clinic of uveitis. That is why the collaboration between ophthalmologics and rheumatologics contribute to a better diagnosis and treatment of patients. In case in which this close collaboration could not be possible, all patients with acute unilateral recurrent uveitis and those with rheumatic complains, should be referred to a rheumatologist, in spite of the absence of rheumatic symptoms.
2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary
Authors: Sana M. Al-Khatib, William G. Stevenson, Michael J. Ackerman, William J. Bryant, David J. Callans, Anne B. Curtis, Barbara J. Deal, Timm Dickfeld, Michael E. Field, Gregg C. Fonarow, Anne M. Gillis, Christopher B. Granger, Stephen C. Hammill, Mark A. Hlatky, José A. Joglar, G. Neal Kay, Daniel D. Matlock, Robert J. Myerburg, Richard L. Page
Journal: Journal of the American College of Cardiology (2017)
Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia
Authors: Lubna H. Abdullah, Raymond Coakley, Megan J. Webster, Yunxiang Zhu, Robert Tarran, Giorgia Radicioni, Mehmet Kesimer, Richard C. Boucher, C. William Davis, Carla M. P. Ribeiro
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Rationale: Cystic fibrosis (CF) airways disease produces a mucoobstructive lung phenotype characterized by airways mucus plugging, epithelial mucous cell metaplasia/hyperplasia, chronic infection, and inflammation. Simultaneous biochemical and functional in vivo studies of mucin synthesis and secretion from CF airways are not available. In vitro translational models may quantitate differential CF versus normal mucin and fluid secretory responses to infectious/inflammatory stimuli.Objectives: We tested the hypothesis that CF airways exhibit defective epithelial fluid, but not mucin, secretory responses to bacterial/inflammatory host products.Methods: Well-differentiated primary human bronchial epithelial cultures were exposed to supernatant from mucopurulent material (SMM) from human CF airways as a test of bacterial/inflammatory host product stimulus. Human bronchial epithelia (HBE) with normal CF transmembrane conductance regulator function were compared with ΔF508/ΔF508 CF HBE.Measurements and Main Results: Acute (up to 60 min) SMM exposure promoted mucin secretion, but mucins were degraded by the proteolytic enzymes present in SMM. Chronic SMM exposure induced upregulation of mucin synthesis and storage and generated absolute increases in basal and stimulated mucin release in normal and CF cultures. These responses were similar in normal and CF cultures. In contrast, SMM produced a coordinated CF transmembrane conductance regulator–mediated Cl− secretory response in normal HBE, but not in CF HBE. The absence of the fluid secretory response in CF produced quantitatively more dehydrated mucus.Conclusions: Our study reveals the interplay between regulation of mucin and fluid secretion rates in inflamed versus noninflamed conditions and why a hyperconcentrated mucus is produced in CF airways.
Interleukin-6 Mediates Post-Infarct Repair by Cardiac Explant-Derived Stem Cells
Authors: Audrey E Mayfield, Pushpinder Kanda, Alex Nantsios, Sandrine Parent, Seth Mount, Somya Dixit, Bin Ye, Richard Seymour, Duncan J Stewart, Darryl R Davis
Journal: Theranostics (2017)

Although patient-sourced cardiac explant-derived stem cells (EDCs) provide an exogenous source of new cardiomyocytes post-myocardial infarction, poor long-term engraftment indicates that the benefits seen in clinical trials are likely paracrine-mediated.Of the numerous cytokines produced by EDCs, interleukin-6 (IL-6) is the most abundant; however, its role in cardiac repair is uncertain.In this study, a custom short-hairpin oligonucleotide lentivirus was used to knockdown IL-6 in human EDCs, revealing an unexpected pro-healing role for the cytokine.Methods: EDCs were cultured from atrial appendages donated by patients undergoing clinically indicated cardiac surgery.The effects of lentiviral mediated knockdown of IL-6 was evaluated using in vitro and in vivo models of myocardial ischemia.Results: Silencing IL-6 in EDCs abrogated much of the benefits conferred by cell transplantation and revealed that IL-6 prompts cardiac fibroblasts and macrophages to reduce myocardial scarring while increasing the generation of new cardiomyocytes and recruitment of blood stem cells.Conclusions: This study suggests that IL-6 plays a pivotal role in EDC-mediated cardiac repair and may provide a means of increasing cell-mediated repair of ischemic myocardium.
Imaging Characteristics of Chemotherapy Related Adult-Onset Still Disease
Authors: Yang Lu, Beth A. Chasen, Homer A. Macapinlac
Journal: Clinical Nuclear Medicine (2017)

A 60-year-old man with lymphoma completed chemotherapy on October 21, 2016, with complete remission. He then received rituximab maintenance therapy. Since March 2017, he has had progressive fatigue, myalgias, rash, weight loss, diarrhea, and recurrent low-grade fever. Subsequent bone marrow biopsy and FDG PET/CT demonstrated no active lymphoma. An In-white blood cell scan showed abnormal tracer uptake on 20-hour postinjection, but not on 3-hour postinjection images, including innumerable skeleton muscle foci, multiple cutaneous foci, and persistent diffuse increased uptake in the lungs. Diagnosis of adult-onset Still disease was made accordingly. The patient's cytopenia was deemed a chemotherapy-related adverse effect.
CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8+ T Cells
Authors: Fernando P. Canale, María C. Ramello, Nicolás Núñez, Cintia L. Araujo Furlan, Sabrina N. Bossio, Melisa Gorosito Serrán, Jimena Tosello Boari, Andrés del Castillo, Marta Ledesma, Christine Sedlik, Eliane Piaggio, Adriana Gruppi, Eva V. Acosta Rodríguez, Carolina L. Montes
Journal: Cancer Research (2017)

The ability of CD8+ T lymphocytes to eliminate tumors is limited by their ability to engender an immunosuppressive microenvironment. Here we describe a subset of tumor-infiltrating CD8+ T cells marked by high expression of the immunosuppressive ATP ecto-nucleotidase CD39. The frequency of CD39highCD8+ T cells increased with tumor growth but was absent in lymphoid organs. Tumor-infiltrating CD8+ T cells with high CD39 expression exhibited features of exhaustion, such as reduced production of TNF and IL2 and expression of coinhibitory receptors. Exhausted CD39+CD8+ T cells from mice hydrolyzed extracellular ATP, confirming that CD39 is enzymatically active. Furthermore, exhausted CD39+CD8+ T cells inhibited IFNγ production by responder CD8+ T cells. In specimens from breast cancer and melanoma patients, CD39+CD8+ T cells were present within tumors and invaded or metastatic lymph nodes, but were barely detectable within noninvaded lymph nodes and absent in peripheral blood. These cells exhibited an exhausted phenotype with impaired production of IFNγ, TNF, IL2, and high expression of coinhibitory receptors. Although T-cell receptor engagement was sufficient to induce CD39 on human CD8+ T cells, exposure to IL6 and IL27 promoted CD39 expression on stimulated CD8+ T cells from human or murine sources. Our findings show how the tumor microenvironment drives the acquisition of CD39 as an immune regulatory molecule on CD8+ T cells, with implications for defining a biomarker of T-cell dysfunction and a target for immunotherapeutic intervention.Significance: The tumor microenvironment elicits a subset of functionally exhausted CD8+ T cells by creating conditions that induce cell surface expression of CD39, an immunosuppressive molecule that can be therapeutically targeted to restore effector T-cell function. Cancer Res; 78(1); 115-28. ©2017 AACR.
Abstract 20654: An Estrogen Receptor α (ERα)-BMPR2-Apelin Axis Mediates 17β-Estradiol’s Protective Effects on Right Ventricular Function in Experimental Pulmonary Hypertension (PH)
Authors: Andrea Frump, Margie Albrecht, Sandra Brueils-Bonnet, Jordan Whitson, Bakhtiyor Yakubov, Mary Beth Brown, Steeve Provencher, Sébastien Bonnet, Tim Lahm
Journal: Circulation (2016)

Introduction: Women with pulmonary arterial hypertension (PAH) exhibit superior RV function and survival compared to men, a phenomenon attributed to poorly understood cardioprotective effects of 17...
Re: Bimal Bhindi, Igor Frank, Ross J. Mason, et al. Oncologic Outcomes for Patients with Residual Cancer at Cystectomy Following Neoadjuvant Chemotherapy: A Pathologic Stage-matched Analysis. Eur Urol 2017;72:660–4
Authors: Giulia I. Lane, Badrinath Konety
Journal: European Urology (2017)
TCT-209 Clinical outcome of a new generation drug-coated balloon for treatment of de novo coronary lesions and in-stent restenosis: an insight from the DCB-RISE registry
Authors: Bernardo Cortese, Gaetano di Palma, Simonetta Blengino, Massimo Fineschi, Renata Rogacka, Corrado Lettieri, Andrea Pavei, Pedro Silva
Journal: Journal of the American College of Cardiology (2017)
Profiling, clinicopathological correlation and functional validation of specific long non-coding RNAs for hepatocellular carcinoma
Authors: Jian Yao, Lingjiao Wu, Xiaohua Meng, Huanxia Yang, Shujun Ni, Qiangfeng Wang, Jiawei Zhou, Qiong Zhang, Kunkai Su, Li Shao, Qingyi Cao, Mingding Li, Fusheng Wu, Lanjuan Li
Journal: Molecular Cancer (2017)

Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignancies worldwide. Studies seeking to advance the overall understanding of lncRNA profiling in HCC remain rare. The transcriptomic profiling of 12 HCC tissues and paired adjacent normal tissues was determined using high-throughput RNA sequencing. Fifty differentially expressed mRNAs (DEGs) and lncRNAs (DELs) were validated in 21 paired HCC tissues via quantitative real-time PCR. The correlation between the expression of DELs and various clinicopathological characteristics was analyzed using Student's t-test or linear regression. Co-expression networks between DEGs and DELs were constructed through Pearson correlation co-efficient and enrichment analysis. Validation of DELs' functions including proliferation and migration was performed via loss-of-function RNAi assays. In this study, we identified 439 DEGs and 214 DELs, respectively, in HCC. Furthermore, we revealed that multiple DELs, including NONHSAT003823, NONHSAT056213, NONHSAT015386 and especially NONHSAT122051, were remarkably correlated with tumor cell differentiation, portal vein tumor thrombosis, and serum or tissue alpha fetoprotein levels. In addition, the co-expression network analysis between DEGs and DELs showed that DELs were involved with metabolic, cell cycle, chemical carcinogenesis, and complement and coagulation cascade-related pathways. The silencing of the endogenous level of NONHSAT122051 or NONHSAT003826 could significantly attenuate the mobility of both SK-HEP-1 and SMMC-7721 HCC cells. These findings not only add knowledge to the understanding of genome-wide transcriptional evaluation of HCC but also provide promising targets for the future diagnosis and treatment of HCC.
Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study
Authors: Elizabeth C Oelsner, Benjamin M Smith, Eric A Hoffman, Aaron R Folsom, Steven M Kawut, Joel D Kaufman, Ani Manichaikul, David J Lederer, Joseph E Schwartz, Karol E Watson, Paul L Enright, John H M Austin, Joao A C Lima, Steven J Shea, Robert G Barr
Journal: Thorax (2017)

Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV 1 /FVC&lt;0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas &lt;—950HU &gt;upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification.
Abstract 10865: Online Multielectrode Catheter-enabled Temporal Tctivation Electrogram Enalysis for Localization of Atrial Fibrillation Rotor Regions: Substrate HD Study
Authors: Clément Bars, Julien Seitz, Guillaume Theodore, Sylvain Beurtheret, Eloi Marijon, Ange Ferracci, Michel Bremondy, Jacques Faure, Laurence Curel, Guillaume Penaranda, Omer Berenfeld, Jérôme Kalifa, André Pisapia
Journal: Circulation (2015)

Introduction: Multi-electrode electrogram temporal activation and fractionation have been used to localize atrial fibrillation (AF) drivers. Yet, the feasibility of a simplified “online” analysis and its usefulness to ablate AF remain to be investigated. Hypothesis: Evaluating a simplified “online” electrogram analysis approach designed to localize and ablate AF drivers. Methods: 105 patients undergoing AF ablation (77% with persistent AF, 3 centres) were prospectively enrolled. AF was first mapped in both atria with the 20-pole contact electrode catheter PentaRay® (Biosense Webster, Inc.) in order to identify regions with a temporal activation pattern compatible with the presence of rapidly rotating rotors. Specifically, regions with consecutive activations spanning the majority of the AF cycle length (including examples of rapid and continuously fractionated electrograms) were visually selected (“hot zone”).The endpoints were AF termination acutely, and freedom from long-term AF (single procedure). Off-line, electrogram cycle length values were compared between “hot” and “non-hot” regions and a numerical simulation of PentaRay-enabled unipolar recordings of a stable rotor driving AF was conducted Results: Visually selected “hot” regions located mostly in the left atrium (6.5 ±4.2/patient; ~70% of ”hot” regions). “Hot” regions were activated at a significantly shorter cycle length than “non-hot” regions (171.8 ± 4.8 vs. 193.0 ± 6.3 ms, p=0.01, N=20). 95.6% of the “hot regions” were automatically labelled CFAEs (automated analysis, Carto). However, 4.5±3.4 distinct CFAEs regions/patient were also labelled in “non-hot” regions. Ablation at “hot” regions terminated AF in 99/104 patients (95.2%), 46 [21-72] min after the 1st radiofrequency application within 20 [10-37] min of RF. Also, numerical simulations show that a simplified PentaRay®-enabled activation analysis is sufficient to distinguish rotor and non-rotor regions. After 9+3 [6-11], months of median [Q1-Q3] follow-up, 87 % were free from AF after 1 procedure and 53 % still under antiarrhythmic drugs. Conclusions: With this simplified “online” analysis, we could successfully localize rotor regions and perform efficient AF ablation. Clinical trial.gov: NCT02093949
Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial
Authors: Peter Holger Johnsen, Frank Hilpüsch, Jorunn Pauline Cavanagh, Ingrid Sande Leikanger, Caroline Kolstad, Per Christian Valle, Rasmus Goll
Journal: The Lancet. Gastroenterology & hepatology (2017)
The proportion of asymptomatic infections and spectrum of disease among pregnant women infected by Zika virus: systematic monitoring in French Guiana, 2016
Authors: Claude Flamand, Camille Fritzell, Séverine Matheus, Maryvonne Dueymes, Gabriel Carles, Anne Favre, Antoine Enfissi, Antoine Adde, Magalie Demar, Mirdad Kazanji, Simon Cauchemez, Dominique Rousset
Journal: Eurosurveillance (2017)

Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, the proportion of ZIKV-infected pregnant women with symptoms remains unknown. Following the emergence of ZIKV in French Guiana, all pregnancies in the territory were monitored by RT-PCR and/or detection of ZIKV antibodies. Follow-up data collected during pregnancy monitoring interviews were analysed from 1 February to 1 June 2016. We enrolled 3,050 pregnant women aged 14-48 years and 573 (19%) had laboratory-confirmed ZIKV infection. Rash, arthralgia, myalgia and conjunctival hyperaemia were more frequently observed in ZIKV-positive women; 23% of them (95% confidence interval (CI): 20-27) had at least one symptom compatible with ZIKV infection. Women 30 years and older were significantly more likely to have symptoms than younger women (28% vs 20%). The proportion of symptomatic infections varied from 17% in the remote interior to 35% in the urbanised population near the coast (adjusted risk ratio: 1.6; 95% CI: 1.4-1.9.). These estimates put findings on cohorts of symptomatic ZIKV-positive pregnant women into the wider context of an epidemic with mainly asymptomatic infections. The proportion of symptomatic ZIKV infections appears to vary substantially between populations.
Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti–T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease–Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation
Authors: Robert J. Soiffer, Haesook T. Kim, Joseph McGuirk, Mitchell E. Horwitz, Laura Johnston, Mrinal M. Patnaik, Witold Rybka, Andrew Artz, David L. Porter, Thomas C. Shea, Michael W. Boyer, Richard T. Maziarz, Paul J. Shaughnessy, Usama Gergis, Hana Safah, Ran Reshef, John F. DiPersio, Patrick J. Stiff, Madhuri Vusirikala, Jeff Szer, Jennifer Holter, James D. Levine, Paul J. Martin, Joseph A. Pidala, Ian D. Lewis, Vincent T. Ho, Edwin P. Alyea, Jerome Ritz, Frank Glavin, Peter Westervelt, Madan H. Jagasia, Yi-Bin Chen
Journal: Journal of Clinical Oncology (2017)

Purpose Several open-label randomized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG; formerly antithymocyte globulin-Fresenius) reduces chronic graft-versus-host disease (cGVHD) without compromising survival. We report a prospective, double-blind phase III trial to investigate the effect of ATLG (Neovii Biotech, Lexington, MA) on cGVHD-free survival. Patients and Methods Two hundred fifty-four patients 18 to 65 years of age with acute leukemia or myelodysplastic syndrome who underwent myeloablative HLA-matched unrelated hematopoietic cell transplantation (HCT) were randomly assigned one to one to placebo (n =128 placebo) or ATLG (n = 126) treatment at 27 sites. Patients received either ATLG or placebo 20 mg/kg per day on days -3, -2, -1 in addition to tacrolimus and methotrexate as GVHD prophylaxis. The primary study end point was moderate-severe cGVHD-free survival. Results Despite a reduction in grade 2 to 4 acute GVHD (23% v 40%; P = .004) and moderate-severe cGVHD (12% v 33%; P < .001) in ATLG recipients, no difference in moderate-severe cGVHD-free survival between ATLG and placebo was found (2-year estimate: 48% v 44%, respectively; P = .47). Both progression-free survival (PFS) and overall survival (OS) were lower with ATLG (2-year estimate: 47% v 65% [ P = .04] and 59% v 74% [ P = .034], respectively). Multivariable analysis confirmed that ATLG was associated with inferior PFS (hazard ratio, 1.55; 95% CI, 1.05 to 2.28; P = .026) and OS (hazard ratio, 1.74; 95% CI, 1.12 to 2.71; P = .01). Conclusion In this prospective, randomized, double-blind trial of ATLG in unrelated myeloablative HCT, the incorporation of ATLG did not improve moderate-severe cGVHD-free survival. Moderate-severe cGVHD was significantly lower with ATLG, but PFS and OS also were lower. Additional analyses are needed to understand the appropriate role for ATLG in HCT.
PS06.06 Immune Checkpoint Markers in Lung Large Cell Neuroendocrine Carcinomas (L- LCNEC)
Authors: N. Abdel Karim, A. Sendilnathan, I. Eldessouki, M. Orr-Asman, C. Xie, J. Wang, H. Elnakat
Journal: Journal of Thoracic Oncology (2017)
TCT-655 Derivation and Validation of a Luminal Diameter Correction Factor for Determination of Stent Sizing by Optical Coherence Tomography: An ILUMIEN III sub-study
Authors: Evan Shlofmitz, Yasir Parviz, Richard Shlofmitz, Bjorn Redfors, Akiko Maehara, Franco Fabbiocchi, Tamim Nazif, Giulio Guagliumi, Perwaiz Meraj, Fernando Alfonso, Takashi Akasaka, Eric Carlson, Massoud Leesar, Mitsuaki Matsumura, M. Ozgu Ozan, Ali Akhund, Gary Mintz, Ori Ben-Yehuda, Gregg Stone, Ziad Ali
Journal: Journal of the American College of Cardiology (2017)
TCT-742 Safety and Efficacy of Ultra-thin Biodegradable Polymer-coated Everolimus-eluting Stent in Real-world Patients with Coronary Artery Disease – One-year Outcomes of Indian Multi-centric ‘EVERsafe’ Study
Authors: Manjinder Sandhu, P. Mangalanandan, Rashmit Pandya
Journal: Journal of the American College of Cardiology (2017)