tbuckley/cabot-search huggingface dataset:
Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c
Authors: Fangshu Wu, Junsheng Zhu, Honglin Li, Lili Zhu
Journal: Acta Pharmaceutica Sinica B (2017)

UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF-α--triggered NF-κB activation. Therefore, UbcH5c is a potent therapeutic target for the treatment of inflammatory and autoimmune diseases induced by aberrant activation of NF-κB. In this study, we established a stable expression system for recombinant UbcH5c and solved the crystal structure of UbcH5c belonging to space group P22121 with one molecule in the asymmetric unit. This study provides the basis for further study of UbcH5c including the design of UbcH5c inhibitors.
Prospective Changes of Cardiac and Hepatic Iron and Cardiac Function By MR in Pediatric Thalassemia Major Patients Treated with Different Chelators or Not Chelated
Authors: Antonella Meloni, Lorella Pitrolo, Blandina Pagano, Giancarlo Izzi, Augusto Scaccetti, Aurelio Maggio, Maria Giovanna Neri, Elisabetta Chiodi, Chiara Tudisca, Cristina Salvatori, Vincenzo Positano, Alessia Pepe
Journal: Blood (2014)
PP38. LIMITATION OF EXTERNAL LIPID SOURCES INDUCES DIFFERENTIAL PROLIFERATIVE AND MORPHOLOGICAL RESPONSES IN ADULT AND PAEDIATRIC GBM CELLS
Authors: Mr James Wood, Dr Dong-Hyun Kim, Mr Safar Alqahtani, Dr Stuart Smith, Prof David Barrett, Prof Richard Grundy, Dr Ruman Rahman
Journal: Neuro-Oncology (2017)

INTRODUCTION: The tumour microenvironment of glioblastoma multiforme (GBM) demonstrates gradients in oxygen and nutrients due to an improperly formed tumour vasculature. Cancer cells obtain lipids for membrane biogenesis through anabolic cellular metabolism or internalisation of lipoproteins from the extracellular milieu. Growth rates of adult GBM cells have been demonstrated to be reduced in the absence of external lipid sources, indicating that de novo synthesis cannot generate the required lipid complement of highly proliferative cancer cells. Here, we evaluate the growth characteristics of paediatric glioma cell lines, to test the hypothesis that paediatric glioma cells demonstrate a similar growth response when cultured in lipoprotein deficient medium (LPDM) as compared to adult GBM cells. MATERIALS AND METHODS: Two paediatric GBM cell lines (KNS42 and SF188) and one paediatric grade I pilocytic astrocytoma (Res186) cell line were cultured in LPDM over a period of 7 days. Complementary experiments on adult counterparts were conducted using the U87 cell line as well as patient-derived tumour cells (GIN-8) isolated from the invasive margin of an adult GBM. Quantitative assessment of cell viability was conducted through crystal violet staining and resazurin-based PrestoBlue assays. RESULTS: Growth in LPDM reduced exponential growth rates and doubling times of KNS42 and SF188 cells after 3 days culture, reaching levels of significance (P<0.05) after 7 days. In contrast, cytostatic growth patterns were observed for Res186, U87 and GIN-8 cells after 3 days culture in LPDM. These cell lines demonstrated morphological changes reminiscent of differentiation (process elongation), whereas KNS42 and SF188 cells demonstrated a largely unaltered tumour cell membrane architecture. CONCLUSIONS: Culture of glioma cells utilising media depleted of external lipoproteins revealed an enhanced capacity of paediatric GBM cells to proliferate under acute metabolic stress compared to adult GBM and grade I paediatric glioma cells. This is suggestive of the ability of paediatric cells to utilise de novo cellular metabolism to generate lipids for proliferation, albeit at a rate that reduces doubling times. Metabolic differences between paediatric and adult cells likely portray differences at the genetic level. Growth of GBM cells under lipoprotein-deplete conditions has the potential to reveal essential metabolic pathways that will inform next-generation targeted treatment strategies.
Darbepoietin in Autologous Peripheral Blood Stem Cell Transplantation (ASCT): A Pilot Study.
Authors: Anna Chierichini, Barbara Anaclerico, Paola Anticoli Borza, Susanna Fenu, Carolina Nobile, Michele Cedrone, Velia Bongarzoni, Maurizio Bartolini, Benedetto Ronci, Luciana Annino
Journal: Blood (2007)
CD4+Foxp3+ Regulatory T Cells Persist in High Numbers in Peripheral Blood after Induction of Clinical Remission with Standard Chemotherapy and Suppress Tumor-Specific Effector T Cells in Patients with Follicular Lymphoma
Authors: Myriam Foglietta, David Delgado, Durgha Nattamai, Larry W Kwak, Sattva Neelapu
Journal: Blood (2008)
Phase 1/2 Study of Tandutinib (MLN518) Plus Standard Induction Chemotherapy in Newly Diagnosed Acute Myelogenous Leukemia (AML).
Authors: Daniel J. DeAngelo, Philip C. Amrein, Tibor J. Kovacsovics, Rebecca B. Klisovic, Bayard L. Powell, Michael Cooper, Iain J. Webb, Richard M. Stone
Journal: Blood (2006)
Evolution of the Genome 3D Organization: Comparison of Fused and Segregated Globin Gene Clusters
Authors: Anastasia P. Kovina, Natalia V. Petrova, Ekaterina S. Gushchanskaya, Konstantin V. Dolgushin, Evgeny S. Gerasimov, Aleksandra A. Galitsyna, Alexey A. Penin, Ilya M. Flyamer, Elena S. Ioudinkova, Alexey A. Gavrilov, Yegor S. Vassetzky, Sergey V. Ulianov, Olga V. Iarovaia, Sergey V. Razin
Journal: Molecular Biology and Evolution (2017)

The genomes are folded in a complex three-dimensional (3D) structure. Some features of this organization are common for all eukaryotes, but little is known about its evolution. Here, we have studied the 3D organization and regulation of zebrafish globin gene domain and compared its organization and regulation with those of other vertebrate species. In birds and mammals, the α- and β-globin genes are segregated into separate clusters located on different chromosomes and organized into chromatin domains of different types, whereas in cold-blooded vertebrates, including Danio rerio, α- and β-globin genes are organized into common clusters. The major globin gene locus of Danio rerio is of particular interest as it is located in a genomic area that is syntenic in vertebrates and is controlled by a conserved enhancer. We have found that the major globin gene locus of Danio rerio is structurally and functionally segregated into two spatially distinct subloci harboring either adult or embryo-larval globin genes. These subloci demonstrate different organization at the level of chromatin domains and different modes of spatial organization, which appears to be due to selective interaction of the upstream enhancer with the sublocus harboring globin genes of the adult type. These data are discussed in terms of evolution of linear and 3D organization of gene clusters in vertebrates.
Safety and Efficiency of New Nonacog Alfa Drug in the Treatment of Bleeding Episodes in Patients with Severe and Moderate Hemophilia B
Authors: Igor Davydkin, Tatiana Andreeva, Vladimir Yu. Zorenko, Valeria Konstantinova, Olga Zalepukhina, Nina Klimova, Georgy Mishin, Igor Kurtov, Maria Shamina, Elena Fatenkova, Olga Gusyakova, Alexandr Shuster, Dmitry Kudlay, Sergey Lukyanov, Anton Borozinets, Eugene Nikitin, Ekaterina Klykova
Journal: Blood (2015)
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
Authors: Ting Chen, Christopher A. Tibbitt, Xiaogang Feng, Julian M. Stark, Leona Rohrbeck, Lisa Rausch, Saikiran K. Sedimbi, Mikael C. I. Karlsson, Bart N. Lambrecht, Gunilla B. Karlsson Hedestam, Rudi W. Hendriks, Benedict J. Chambers, Susanne Nylén, Jonathan M. Coquet
Journal: Science Immunology (2017)

A hallmark of immunity to worm infections and many allergies is a strong type 2 immune response. This is characterized by the production of cytokines interleukin-5 (IL-5) and IL-13 by adaptive T helper 2 (TH2) cells and/or type 2 innate lymphoid cells. Peroxisome proliferator activated receptor-γ (PPAR-γ) is typically regarded as an anti-inflammatory factor. We report that TH2 cells express high levels of PPAR-γ in response to the allergen house dust mite and after infection with the parasite Heligmosomoides polygyrus Mice lacking PPAR-γ in T cells failed to effectively differentiate into IL-5- and IL-13-secreting cells and, hence, did not develop TH2 cell-associated pathologies, including goblet cell metaplasia and eosinophilia, in response to allergen challenge. Furthermore, these mice could not mount protective immune responses to nematode infection. In addition, mice lacking PPAR-γ in T cells had greatly reduced frequencies of TH2 cells in visceral adipose tissue. Mechanistically, PPAR-γ appeared to promote the expression of the IL-33 receptor on the surface of TH2 cells. These results pinpoint PPAR-γ as a factor that drives type 2 responses in allergy, worm infection, and visceral adipose tissue.
Potential Therapeutic Applications of Jak2 Inhibitors and Hif2a-ASO for the Treatment of β-Thalassemia Intermedia and Major
Authors: Carla Casu, Paraskevi Rea Oikonomidou, Vania Lo Presti, Mariam Aghajan, Shuling Guo, Abdulmalik Osheiza, Luca Melchiori, Pedro Ramos, Stefano Rivella
Journal: Blood (2016)
Incident opioid drug use and adverse respiratory outcomes among older adults with COPD
Authors: Magnus Ekström, Sabrina Bajwah, Miriam J. Johnson
Journal: European Respiratory Journal (2017)

We read with great interest the observational, registry-based study of the association between an incident opioid prescription and risk of subsequent hospitalisation or death within 30 days in people aged 66 years or older in the community with a diagnosis of chronic obstructive pulmonary disease (COPD), published recently in the European Respiratory Journal [1]. The study was carefully conducted and accounts for potential confounding factors for which data were available. However, as with all observational studies, there are issues that affect interpretation of the findings and their application to clinical practice. Extended-release morphine is underused for breathlessness. Careful titration will ensure better symptom control <http://ow.ly/wtN03095IdM>
PP39. 5-AMINOLEVULINIC ACID AIDED RESECTION OF PAEDIATRIC BRAIN TUMOURS: THE UK’S FIRST CASE SERIES
Authors: Ms Charlotte Burford, Ms Nida Kalyal, Dr Anand Pandit, Mr Jignesh Tailor, Mr Jose Pedro Lavrador, Ms Angela Bravo, Ms Airi Kugisaki, Prof Keyoumars Ashkan, Mr Sanjeev Bassi, Mr Christopher Chandler, Dr Stergios Zacharoulis, Mr Bassel Zebian
Journal: Neuro-Oncology (2017)

BACKGROUND: 5-aminolevulinic acid (5-ALA, Gliolan) use is well documented and established in the resection of adult high-grade gliomas. There is growing interest in its safety and usefulness in the paediatric populations. The main challenge in the latter is the diverse range of histopathological tumour types that can occur. We present the UK’s first case series of 5-ALA use in the paediatric population. METHODS: Parental consent was obtained for the 6 patients (age 1.6–15 years, median 6.5 years) to be given a dose of 20mg/kg of 5-ALA 3 hours pre-operatively. Intra-operatively the tumours were viewed under violet-blue light and the presence of fluorescence was recorded. Fluorescence status was compared with histopathological classification and grade. RESULTS: The case series included: a pilocytic astrocytoma (grade I), a pilomyxoid astrocytoma (II), a glioneuronal tumour (II), a ganglioglioma (II-III), an anaplastic ependymoma (III) and an anaplastic medulloblastoma (IV). Only the grade III ependymoma showed strong fluorescence with 5-ALA. The pilocytic astrocytoma (I) and pilomxyoid astrocytoma (II) showed moderate fluorescence and the ganglioglioma (II-III) showed weak fluorescence. No fluorescence was observed in the glioneuronal tumour (II) or the medulloblastoma (IV). No significant adverse drug reactions were recorded. CONCLUSION: This case series adds to the growing body of evidence demonstrating the safety of 5-ALA in the paediatric population. Our case series highlights the need for larger trials into the usefulness of 5-ALA in the different paediatric brain tumour types. KEYWORDS: 5-aminolevulinic, 5-ALA, Gliolan, Fluoresence, Paediatric, Child, Brain tumour
Erratum: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
Authors: Claire Palles, Jean-Baptiste Cazier, Kimberley M Howarth, Enric Domingo, Angela M Jones, Peter Broderick, Zoe Kemp, Sarah L Spain, Estrella Guarino, Israel Salguero, Amy Sherborne, Daniel Chubb, Luis G Carvajal-Carmona, Yusanne Ma, Kulvinder Kaur, Sara Dobbins, Ella Barclay, Maggie Gorman, Lynn Martin, Michal B Kovac, Sean Humphray, Anneke Lucassen, Christopher C Holmes, David Bentley, Peter Donnelly, Jenny Taylor, Christos Petridis, Rebecca Roylance, Elinor J Sawyer, David J Kerr, Susan Clark, Jonathan Grimes, Stephen E Kearsey, Huw J W Thomas, Gilean McVean, Richard S Houlston, Ian Tomlinson
Journal: Nature Genetics (2013)
Children’s diabetes control improves but gaps in care remain, audit finds
Authors: Zosia Kmietowicz
Journal: BMJ (2017)

More than a quarter of children in England and Wales with diabetes now have excellent blood glucose control, while the number said to have poor control has fallen, the latest paediatric audit has found.1

It found signs, however, that some children are not getting the care they need. The 2015-16 audit found that 13.8% had early signs of eye disease, up from 12.8% in 2014-15. Children with type 1 diabetes were also more likely to be overweight or obese than the general population.

The National Paediatric Diabetes Audit,1 which has been carried out since 2003, is …
Anemia Associated with Chronic Disease in Patients with Chronic Lymphocytic Leukemia Is Not Attributed to Decreased Production or Impaired EPO Signaling of Erythroid Precursors.
Authors: Olga Tsopra, Panos Ziros, Eleni Lagadinou, Alexandra Kouraklis, Argiris Symeonidis, Eleni Thanopoulou, Panagiotis Zikos, Nicholas C. Zoumbos
Journal: Blood (2006)
Immune Microenvironment in Microsatellite-Instable Endometrial Cancers: Hereditary or Sporadic Origin Matters
Authors: Janelle B. Pakish, Qian Zhang, Zhongyuan Chen, Han Liang, Gary B. Chisholm, Ying Yuan, Samuel C. Mok, Russell R. Broaddus, Karen H. Lu, Melinda S. Yates
Journal: Clinical Cancer Research (2017)

Abstract Purpose: Recent studies show that colorectal tumors with high microsatellite instability (MSI-H) have increased immunogenicity and response to immunotherapy compared with microsatellite-stable (MSS) tumors. It is not yet clear whether MSI-H endometrial cancer may also benefit from these therapies. It is also unknown whether immune response is equivalent in MSI-H endometrial cancer with sporadic or inherited Lynch syndrome origins. Experimental Design: Multiplexed fluorescent IHC was used to compare matched MSI-H (n = 60) and MSS (n = 96) endometrial cancer specimens by evaluating immune cell populations in tumor and stroma compartments. Sporadic MSI-H and Lynch syndrome–associated (LS) MSI-H endometrial cancers were also directly compared. Results: Increased immune cells were present in stroma of MSI-H endometrial cancer compared with MSS, including granzyme B+ cells, activated CTLs (CD8+granzyme B+), and PD-L1+ cells. Granzyme B+ cells and activated CTLs were also increased in the tumor compartment of MSI-H endometrial cancers. Comparing sporadic and LS MSI-H endometrial cancer showed distinct differences in immune cell populations, indicating that mechanisms underlying microsatellite instability alter immune response. Specifically, LS MSI-H endometrial cancer showed increased CD8+ cells and activated CTLs in stroma, with reduced macrophages in stroma and tumor compared with sporadic MSI-H. Sporadic MSI-H had increased PD-L1+ macrophages in stroma and tumor compared with LS MSI-H endometrial cancer. Conclusions: MSI-H endometrial cancer has increased immune cell infiltration compared with MSS endometrial cancer and the hereditary or sporadic origin of microsatellite instability impacts immune response. Clinical trials to determine the role of immunotherapy in patients with MSI-H endometrial cancer must evaluate Lynch syndrome–related and sporadic MSI-H tumors separately. Clin Cancer Res; 23(15); 4473–81. ©2017 AACR.
BURDEN OF ARRHYTHMIAS IN PERIPARTUM CARDIOMYOPATHY: ANALYSIS OF 9,840 HOSPITALIZATIONS
Authors: Sagar Mallikethi Lepakshi Reddy, Alexandros Briasoulis, Mazhar Khan, Melvyn Rubenfire, Cindy Grines, Robert Brook, Luis Afonso
Journal: Journal of the American College of Cardiology (2016)
Intelligence and fertility.
Authors: J A Fraser Roberts
Journal: BMJ (1972)

radical irradiation.The 5 and 10-year crude survival rates for cases treated in this way are 85% and 72%, respectively.Over 90% of the patients were in good general health with no serious neurological or mental dis- ability at two years; vision was good or useful in 82%°,.For patients treated in the most recent period using a 6 MeV linear accelerator, the 3-year survival rate for 31 patients was 94%, while at five years 11 of 12 cases (92°%) were still alive and well.These early results for radiotherapy, together with those quoted above, appear to be more than a challenge to that reported for radical sur- gery.We are concerned, not only that your authoritative columns should claim that radical surgery is the best treatment, but that it is said to be the only effective treat- ment; this is surely a question which now demands re-evaluation.-Weare, etc.,
13q14 Chromosome Deletion Size and Number of Deleted Cells Influence Prognosis In Chronic Lymphocytic Leukemia
Authors: Francesca Maria Rossi, Davide Rossi, Clara Deambrogi, Francesco Bertoni, Michele Dal Bo, Ilaria Del Giudice, Andrea Rinaldi, Ivo Kwee, Giuseppe A Palumbo, Mauro Nanni, Giorgia Corradini, Erika Tissino, Marco Ladetto, Angela Coletta, Fabrizio Luciano, Alessandro Gozzetti, Rosaria Crupi, Gabriele Pozzato, Luca Laurenti, Francesco Forconi, Francesco Di Raimondo, Roberto Marasca, Giovanni Del Poeta, Robin Foá, Gianluca Gaidano, Anna Guarini, Valter Gattei
Journal: Blood (2010)
Abstract B23: Neuroblastoma patient-derived orthotopic xenografts: Clinically relevant models for drug testing
Authors: Daniel Bexell, Noémie Braekeveldt, Sofie Mohlin, Caroline Wigerup, David Gisselsson, Irene Tadeo, Ana P. Berbegall, Sam Navarro, Rosa Noguera, Sven Påhlman
Journal: Clinical Cancer Research (2016)

Abstract Background: We previously established neuroblastoma patient-derived orthotopic xenografts (PDXs) by implanting patient neuroblastoma fragments into immunodeficient NSG mice. SNP array analysis confirmed that PDXs maintain patient-specific chromosomal aberrations 1p del, MYCN amp and 17q gain. Immunohistochemistry showed that PDXs retain neuroblastoma markers and a highly infiltrative growth pattern. Importantly, we found spontaneous distant metastasis to lungs, liver and bone marrow. In vitro cultures established from the PDXs express neuroblastoma markers and retain their tumorigenic and metastatic ability in vivo after orthotopic injection. Methods and Results: Given the important role of the tumor stroma for tumor progression and treatment response, we examined PDX stroma by immunohistochemistry. PDXs were highly vascularized with mouse endothelial cells and two PDX models also formed tumor vasculature by co-engrafted human tumor endothelial cells. Tumors contained pericytes, cancer-associated fibroblasts, macrophages and extracellular components resembling the patient disease. PDXs established in athymic nude mice additionally developed intratumoral lymphatic vessels and contained mouse-derived CD45+ lymphoid cells. Thus, PDXs reflect important tumor microenvironment hallmarks for high-stage neuroblastoma. Furthermore, we demonstrate the feasibility of using short-term in vitro cultured PDX-derived cells as a drug-testing model, and show that the HIF2A oncogene is transcriptionally regulated at hypoxia via the PI3K/mTORC2 pathway in these cells. The results establish the PI3K and mTORC2 pathways as potential therapeutic targets of aggressive neuroblastoma. Conclusion: Neuroblastoma orthotopic PDXs reflect clinical aspects of high-risk disease including spontaneous metastasis, copy number changes and microenvironmental hallmarks. Neuroblastoma PDXs are relevant models for in vitro and in vivo preclinical drug testing. Citation Format: Daniel Bexell, Noémie Braekeveldt, Sofie Mohlin, Caroline Wigerup, David Gisselsson, Irene Tadeo, Ana P. Berbegall, Sam Navarro, Rosa Noguera, Sven Påhlman. Neuroblastoma patient-derived orthotopic xenografts: Clinically relevant models for drug testing. [abstract]. In: Proceedings of the AACR Special Conference: Patient-Derived Cancer Models: Present and Future Applications from Basic Science to the Clinic; Feb 11-14, 2016; New Orleans, LA. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(16_Suppl):Abstract nr B23.
Analysis of Cord Blood Unit (CBU) Segment for CD34+ Cell Viability and Hematopoietic Progenitor Cell Content Correlates with the Post-Thaw CBU After Albumin-Dextran Reconstitution.
Authors: Andromachi Scaradavou, Maria S Albano, Nela-Ludy Dobrila, Katharine Smith, Marissa N Lubin, Joann Tonon, Dorothy Sung, Cladd Stevens, Juliet N Barker
Journal: Blood (2012)
Erratum: The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma (Blood Cancer Journal (2011) 1 (e46) DOI:10.1038/bcj.2011.46)
Authors: E. Derenzini, M. Lemoine, D. Buglio, H. Katayama, Y. Ji, R. E. Davis, S. Sen, A. Younes
Journal: Blood Cancer Journal (2014)
Importance of JAK2 V617F Allele Burden in the Diagnosis of Myeloproliferative Diseases and Its Association to Age.
Authors: Inmaculada Rapado, Enriqueta Albizua, Rosa Ayala, Jose Angel Hernandez, Luis Garcia-Alonso, Silvia Grande, Miguel Gallardo, Florinda Gilsanz, Joaquin Martinez-Lopez
Journal: Blood (2007)
Abstract P2-01-36: Ex vivo shear-wave elastography of axillary lymph nodes predicting nodal metastasis in patients with primary breast cancer: A pilot study
Authors: JW Lim, HW Lee, JT Park, SG Ahn, J Jung
Journal: Cancer Research (2017)

Abstract Objective: To evaluate the feasibility of shear-wave elastography using breast ultrasonography in identifying metastasis of removed sentinel lymph nodes during the operation for treatment of breast cancer. Background: Conventional method for identification of sentinel nodal metastasis is time and cost consuming. The optimal method for identification of nodal status is important. Methods: Excised sentinel lymph nodes during the operation were prospectively examined with the elastography. Metastatic status of lymph nodes was confirmed with permanent histology. Only macrometastasis was regarded as positive. Elastic values measured by the ex vivo elastography and nodal characteristics were analyzed to correlate with nodal metastasis. Results: A total of 274 lymph nodes harvested from 68 breast cancer patients at Gangnam Severance Hospital from May 2014 to April 2015 were included this study. There was the difference of elastic values between nodes with and without metastasis (mean stiffness, 41.6 kPa and 17.4 kPa, P &amp;lt; 0.001). Mean sizes of metastatic nodes (range 0.36-2.59 cm) were significantly larger than that of non-metastatic nodes (1.0 cm versus 0.75 cm, P &amp;lt; 0.001). Moreover, there was a correlation between the size of metastatic nodes which ranged from 0.7 to 21.5 mm with a median of 7 mm and nodal stiffness (correlation coefficient of mean stiffness, r = 0.431). The area under the receiver operating characteristic curve (AUC) by the mean stiffness was 0.794. The combination of size of nodes, mean stiffness and ratio made AUC of 0.856. Conclusions: In our study, ex vivo shear-wave elastography of sentinel lymph nodes was a feasible method to predict metastasis. Through the validation study, ex vivo elastography could be helpful to determine metastasis of sentinel lymph nodes during the operation. Keywords Breast cancer; Elastography; Lymph node metastasis. Citation Format: Lim JW, Lee HW, Park JT, Ahn SG, Jung J. Ex vivo shear-wave elastography of axillary lymph nodes predicting nodal metastasis in patients with primary breast cancer: A pilot study [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P2-01-36.