tbuckley/cabot-search huggingface dataset:
Highlights of the American College of Cardiology Annual Scientific Sessions 2017
Authors: Jeffrey T. Kuvin, Andrew M. Kates
Journal: Circulation (2017)

ecently, the 66th Annual American College of Cardiology (ACC) Scientific Sessions convened in Washington, DC, building on the theme of "more learning, less lecturing".Despite the challenge of winter storm Stella, the meeting went off without a hitch, bringing together more than 18 500 attendees from across the world.Clinical science was at the forefront of the meeting, with 23 late-breaking clinical trials and 17 featured clinical research presentations.In addition, ACC.17 (2017 American College of Cardiology Annual Scientific Sessions) offered an updated core curriculum program, half-day intensive sessions focusing on palliative care, healthcare equity, and faculty development, live case demonstrations, and a personalized skills center, featuring hands-on simulation and test question review.Audience participation and response were featured throughout the meeting.New this year, physician attendees received simultaneous credit for continuing medical education and American Board of Internal Medicine Maintenance of Certification (ABIM-MOC) for the majority of the educational sessions; European physicians received external continuing medical education credit; and pharmacists and nurses received continuing education credits.
Interferon-free antiviral therapy does not increase the risk of developing short term hepatocellular carcinoma in patients with cirrhosis infected with hepatitis C virus
Authors: A. Nuñez, V. Aguilera, Y. Sánchez-Torrijos, J.M. Sousa, M.T. Ferrer, A. Giraldez, J. Ampuero, J. Pérez-Martinez, M. Cuaresma, R. Ruiz-Pérez, J.M. Pascasio
Journal: Journal of Hepatology (2017)
Hepatitis B : Antiviral efficacy of adefovir dipivoxil in Lamivudine- resistant chronic hepatitis B: the optimal duration of Lamivudine overlap (초)
Authors: Young Sang Byoun, Hee Sup Kim, Sook Hyang Jeong, Ho Kil, Bo Young Min, Sang Hyub Lee, Jin Wook Kim, Jin Hyuk Hwang, Young Soo Park, Na Young Kim, Dong Ho Lee
Journal: Clinical and Molecular Hepatology (2011)
An Innovative app focused on patients and caregivers significantly decreases avoidable and HE-related readmissions in cirrhotic patients
Authors: D. Ganapathy, J. Lachar, C. Acharya, M. White, R.K. Sterling, S. Matherly, P. Puri, R.T. Stravitz, M.S. Siddiqui, A.J. Sanyal, H. Lee, V. Luketic, K. Patidar, C. Ignudo, S. Bommidi, J.S. Bajaj
Journal: Journal of Hepatology (2017)
Screening for pulmonary arterial hypertension in an unselected prospective systemic sclerosis cohort
Authors: Els Vandecasteele, Benny Drieghe, Karin Melsens, Kristof Thevissen, Michel De Pauw, Ellen Deschepper, Saskia Decuman, Carolien Bonroy, Yves Piette, Filip De Keyser, Guy Brusselle, Vanessa Smith
Journal: European Respiratory Journal (2017)

Screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) improves outcomes. The DETECT screening algorithm is recommended in a high-risk SSc subgroup. This study aims to compare prospectively the positive predictive value of screening using the DETECT algorithm and the 2009 European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines, and to compare their cost-effectiveness in an unselected, day-to-day SSc population. Post hoc, screening according to the 2015 ESC/ERS guidelines using echocardiographic parameters alone ("2015 echo screening") or combined with the DETECT algorithm ("2015 combined screening") in high-risk subjects was analysed.195 consecutive SSc patients included in the Ghent University Hospital SSc cohort were screened using different algorithms.The referral rate for right heart catheterisation was 32% (63 out of 195 patients) (46/4/13/34/40 patients using the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). Right heart catheterisation was performed in 53 patients (84%) (36 (78%)/four (100%)/13 (100%)/28 (82%)/32 (80%) patients recommended by the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). PAH was diagnosed in three patients (incidence 1.5%·year-1, 95% CI 0.5-4.4), in whom all algorithms recommended a right heart catheterisation. The positive predictive value was 6% (95% CI 2-17%; three out of 49 patients) for the DETECT algorithm, 18% (95% CI 6-41%; three out of 17 patients) for the 2009 guidelines, 23% (95% CI 8-50%; three out of 13 patients) for both, 11% (95% CI 4-27%; three out of 28 patients) for the 2015 echo screening and 9% (95% CI 3-24%; three out of 32 patients) for the 2015 combined screening. The cost was EUR224/80/90/112 per patient using the DETECT algorithm/2009 guidelines/2015 echo screening/2015 combined screening.Echocardiography may remain a candidate first step for PAH screening in SSc.
Can HCV core antigen replace HCV RNA testing in the era of direct-acting antivirals?
Authors: M. Van Tilborg, S. Almarzooqi, R. Maan, J. Vermehren, B. Maasoumy, T. Mazzulli, M. Kowgier, H.L. Janssen, R.J. De Knegt, J.-M. Pawlotsky, G. Cloherty, C. Sarrazin, H. Wedemeyer, J.J. Feld
Journal: Journal of Hepatology (2017)
Identification of tumour suppressive and oncogenic microRNAs in gallbladder carcinoma
Authors: B. Goeppert, M. Renner, F. Truckenmueller, A. Fraas, C. Sticht, D. Scherer, J.L. Bermejo, N. Gretz, P. Schirmacher, S. Roessler
Journal: Journal of Hepatology (2017)
Benefits of Cardiac Resynchronization Therapy Persist at Advanced Age
Authors: Frederik Hendrik Verbrugge, Lars Grieten, Matthias Dupont, Philippe De Vusser, Maximo Rivero-Ayerza, Hugo Van Herendael, Linda Jacobs, Jan Vercammen, David Verhaert, Pieter M Vandervoort, W H Wilson Tang, Wilfried Mullens
Journal: Circulation (2012)
Previously treated advanced NSCLC cohort from a multi-disease phase 1 study of ramucirumab (R) plus pembrolizumab (P): Efficacy and safety data
Authors: R.S. Herbst, J. Martin-Liberal, E. Calvo, N. Isambert, J. Bendell, P. Cassier, J. Jin, G. Mi, J. Rege, L. Paz-Ares
Journal: Annals of Oncology (2017)
Abstract A03: FGF-WNT cooperativity and the role of lncRNAs in translational regulation in breast cancer
Authors: Tuan M. Nguyen, Elena B. Kabotyanski, Lucas C. Reineke, Qianxing Mo, Peng Zhang, Xiang Zhang, Yiwen Chen, Joel Neilson, Richard E. Lloyd, Jeffrey M. Rosen
Journal: Cancer Research (2017)

Abstract The purpose of this study is to understand translational mechanisms underlying the cooperativity between FGF and WNT signaling in cancer progression. FGF and WNT signaling, crucial pathways in mammary stem cell self-renewal, are frequently deregulated in human cancer. We previously showed that acute activation of FGF signaling in the mammary gland of pubertal mice with WNT hyperactivation dramatically accelerates cancer progression. FGF-WNT-hyperactive tumor cells exhibit enhanced activation of translational machinery. Given the potential involvement of translational regulation in FGF-WNT induced tumorigenesis, we employed ribosome profiling to identify selectively translated and ribosome associated RNAs induced by acute FGF activation in vivo. Many genes associated with RNA processing and transport were translationally upregulated. Interestingly, the most translationally upregulated transcript was Malat1, originally thought to be a nuclear-restricted long noncoding RNA (lncRNA) that regulates transcription of cancer-associated genes. Along with Malat1, many lncRNAs were associated with ribosomes in FGF-WNT tumors. Malat1's association with polysomes upon acute FGF activation was confirmed by direct polysome analysis. We also demonstrated that Malat1 transcripts are transported to the cytoplasm during G2/M transition, implicating that Malat1 may be translated into small novel peptides or involved in translation regulation during this particular phase of cell cycle. Additionally, there is evidence that Malat1 is a direct downstream target of WNT signaling. Our findings indicate that FGF activation potentially increases the translation efficiency of WNT-target oncogenes including lncRNAs like Malat1, unraveling a novel mechanism of crosstalk between lncRNAs and translational regulation in cancer progression. Citation Format: Tuan M. Nguyen, Elena B. Kabotyanski, Lucas C. Reineke, Qianxing Mo, Peng Zhang, Xiang Zhang, Yiwen Chen, Joel Neilson, Richard E. Lloyd, Jeffrey M. Rosen. FGF-WNT cooperativity and the role of lncRNAs in translational regulation in breast cancer. [abstract]. In: Proceedings of the AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy; 2016 Oct 27-30; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2017;77(6 Suppl):Abstract nr A03.
Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice
Authors: Xuezhen Zeng, Xi Li, Chenshu Xu, Fulin Jiang, Yufei Mo, Xiaomei Fan, Yaoting Li, Yiming Jiang, Dongshun Li, Min Huang, Huichang Bi
Journal: Acta Pharmaceutica Sinica B (2017)

Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available. Wuzhi Tablet (WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepato-protective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ and the target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway.
Treatment of patients with hepatitis C virus genotype 5 and 6: descriptive analysis of the Hepa-C registry
Authors: M.H. Conde, I. Fernández, C.F. Carrillo, A. Albillos, C. Pons, E. Badia, J. García-Samaniego, J.M.M. Planas, J.L. Calleja
Journal: Journal of Hepatology (2017)
Radiotherapy for nasal cavity and Waldeyer ring natural killer/T-cell lymphoma: Analysis in 131 patients.
Authors: Yuan Zhu, Luying Liu, Jialing Luo
Journal: Journal of Clinical Oncology (2013)

8553 Background: Theaim of this study was to evaluate the efficacy and prognosis of chemotherapy and radiotherapy for patients with nasal cavity and Waldeyer ring natural killer/T cell lymphoma. Methods: Records of 131 patients who received chemotherapy or radiotherapy or chemoradiotherapy at Zhejiang Cancer Hospital between 2000 and 2010, were retrospectively reviewed. Ninety-eight patients received chemoradiotherapy. Thirty patients received radiotherapy, and three patients received chemotherapy. All patients had pathology and immunohistochemistry diagnosis. According to the Ann Arbor Staging System, majority of patients were staged as IE stage (116/131). 14 patients presented with IIE stage, and 1 IIIE stage. Thirty-four patients had B symptoms. Results: 109 patients were with nasal cavity NK/T cell lymphoma, and 22 patients with Waldeyer ring NK/T cell lymphoma. Complete response (CR) was achieved in 116 (89%) patients. The 5-year overall survival (OS) rate and disease-free survival (DFS) rate for all patients were 62.7% and 53.5%, respectively. 5-year OS in patients with RT dose ³a50Gy and &lt; 50Gy were 64% and 45.4% respectively (p =0.024). No survival difference was observed between patients with nasal cavity and Waldeyer ring, treated with radiotherapy and chemoradiotherapy, with or without B symptoms, CD56(+) and CD56(-), and between stage IE and IIE patients. On multivariate analysis, the level of lactate dehydrogenase (LDH) before treatment and dose of RT were correlated with prognosis (p&lt;0.05). Conclusions: Radiotherapy, as the primary therapy, can result in a favorable outcome in the treatment of nasal cavity and Waldeyer ring natural killer/T cell lymphoma. The patients with the lower level of LDH before treatment, RT dose ≥50Gy had better prognosis. Addition chemotherapy to radiotherapy didn’t improve the survival.
Abstract IA20: Monitoring translation in space and time with ribosome profiling
Authors: Jonathan Weissman
Journal: Cancer Research (2017)

Abstract The ability to sequence genomes has far outstripped approaches for deciphering the information they encode. We have developed a suite of techniques based on ribosome profiling (deep sequencing of ribosome protected fragments) that dramatically expand our ability to follow translation in vivo. I will present recent applications of our ribosome profiling approach including the following: (1) Development of ribosome profiling protocols for a wide variety of eukaryotic and prokaryotic organisms. (2) Uses of ribosome profiling to globally monitor when chaperones, targeting factors or processing enzymes engage nascent chains. (3) Application of ribosome profiling to define the protein coding potential of complex genomes. (4) The development of a proximity-specific ribosome profiling assay for monitoring subcellular localized translation and its use to follow translation on the surface of the endoplasmic reticulum and mitochondria. Citation Format: Jonathan Weissman. Monitoring translation in space and time with ribosome profiling. [abstract]. In: Proceedings of the AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy; 2016 Oct 27-30; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2017;77(6 Suppl):Abstract nr IA20.
A new in vitro hepatocellular carcinoma model based on human normal and fibrotic 3D extracellular matrix scaffold bio-engineering
Authors: A. Telese, G. Mazza, L. Longato, W. Al-Akkad, L. Frenguelli, G. Marrone, D. Tamburrino, G. Spoletini, A. Hall, T.V. Luong, K. Moore, M. Malagò, M. Pinzani, K. Rombouts
Journal: Journal of Hepatology (2017)
High prevalence of chronic hepatitis C in injecting drug users in Tanzania, East Africa: a neglected burden of disease
Authors: Z. Mohamed, J. Mbwambo, J. Rwegasha, Y. Shimakawa, S. Bhagani, S. Chevaliez, J. Makani, S. Taylor-Robinson, M. Thursz, M. Lemoine
Journal: Journal of Hepatology (2017)
Human ascites microfibril-associated protein 4 is an independent predictor of mortality in decompensated cirrhosis
Authors: B.S. Madsen, M. Kjærgaard, M. Thiele, A. Pohlmann, P. Lutz, R. Schierwagen, S. Klein, C. Jansen, J. Lehmann, C.O. Mortensen, A.W. Knudsen, J. Trebicka, A. Schlosser, U. Holmskov, G.L. Sorensen, A. Krag
Journal: Journal of Hepatology (2017)
IL6-174GG genotype is associated with diabetes mellitus type 2 in patients with chronic hepatitis C
Authors: D.A. Vieira, M.T.B. de Almeida, L.R. da Cunha, T. Bering, K.G.D. Diniz, A.D. Gomes, C.L.L. Faria Junior, R. Teixeira, G.A. Rocha, D.M.D.M. Queiroz, L.D.D. Silva
Journal: Journal of Hepatology (2017)
Checkpoint inhibitors in hematological malignancies
Authors: Chi Young Ok, Ken H. Young
Journal: Journal of Hematology & Oncology (2017)

Inhibitory molecules such as PD-1, CTLA-4, LAG-3, or TIM-3 play a role to keep a balance in immune function. However, many cancers exploit such molecules to escape immune surveillance. Accumulating data support that their functions are dysregulated in lymphoid neoplasms, including plasma cell myeloma, myelodysplastic syndrome, and acute myeloid leukemia. In lymphoid neoplasms, aberrations in 9p24.1 (PD-L1, PD-L2, and JAK2 locus), latent Epstein-Barr virus infection, PD-L1 3′-untranslated region disruption, and constitutive JAK-STAT pathway are known mechanisms to induce PD-L1 expression in lymphoma cells. Clinical trials demonstrated that PD-1 blockade is an attractive way to restore host’s immune function in hematological malignancies, particularly classical Hodgkin lymphoma. Numerous clinical trials exploring PD-1 blockade as a single therapy or in combination with other immune checkpoint inhibitors in patients with hematologic cancers are under way. Although impressive clinical response is observed with immune checkpoint inhibitors in patients with certain cancers, not all patients respond to immune checkpoint inhibitors. Therefore, to identify best candidates who would have excellent response to checkpoint inhibitors is of utmost importance. Several possible biomarkers are available, but consensus has not been made and pursuit to discover the best biomarker is ongoing.
Hepatitis C Virus Infection Among Women Giving Birth — Tennessee and United States, 2009–2014
Authors: Stephen W. Patrick, Audrey M. Bauer, Michael D. Warren, Timothy F. Jones, Carolyn Wester
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Hepatitis C virus (HCV) affects an estimated 3.5 million persons in the United States (1), making it the most common bloodborne infection in the country. Recent surveillance data showed increased rates of HCV infection among adolescents and adults who are predominantly white, live in nonurban areas, and have a history of injection drug use.* U.S. birth certificate data were used to analyze trends and geographic variations in rates of HCV infection among women giving birth during 2009-2014. Birth certificates from Tennessee were used to examine individual characteristics and outcomes associated with HCV infection, using a multivariable model to calculate adjusted odds of HCV-related diagnosis in pregnancy among women with live births. During 2009-2014, HCV infection present at the time of delivery among pregnant women from states reporting HCV on the birth certificate increased 89%, from 1.8 to 3.4 per 1,000 live births. The highest infection rate in 2014 (22.6 per 1,000 live births) was in West Virginia; the rate in Tennessee was 10.1. In adjusted analyses of Tennessee births, the odds of HCV infection were approximately threefold higher among women residing in rural counties than among those in large urban counties, 4.5-fold higher among women who smoked cigarettes during pregnancy, and nearly 17-fold higher among women with concurrent hepatitis B virus (HBV) infection. HCV infection among pregnant women is an increasing and potentially modifiable threat to maternal and child health. Clinicians and public health officials should consider individual and population-level opportunities for prevention and risk mitigation.
Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?
Authors: S.H. Kardaun, A. Sidoroff, L. Valeyrie-Allanore, S. Halevy, B.B. Davidovici, M. Mockenhaupt, J.C. Roujeau
Journal: British Journal of Dermatology (2007)

Drug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological patterns, but sometimes the early distinction between 2 SCARs can be extremely challenging, and overlapping conditions could therefore be taken into consideration, although true overlapping SCARs are very rare when using strict diagnostic criteria (described by the RegiSCAR group). Only a better understanding of the physiopathology of the SCARs could possibly explain these ambiguities and overlaps. We report a case of SCAR in an 86-year-old patient probably induced by allopurinol and simultaneously fulfilling the diagnostic criteria for DRESS and SJS, thus considered as an overlapping case of SCARs.
Computed tomography scanning in mycosis fungoides: optimizing the balance between benefit and harm
Authors: A. Spencer, P. Gazzani, R. Gadvi, S.J. Hughes, A. Stevens, F. Shah, J. Scarisbrick
Journal: British Journal of Dermatology (2017)

Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL), accounting for 55% cases1. Although incurable, it most often presents in early-stage with a good prognosis. The primary aim is to minimise symptoms and maximise quality of life. The UK British Association of Dermatologists 2003 guidelines recommend a staging computed tomography (CT) scan of the neck, thorax, abdomen and pelvis for patients with stage IIA and above2.

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Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients
Authors: Christin Schmidt, Nil A Schubert, Sebastian Brabetz, Norman Mack, Benjamin Schwalm, Jennifer A Chan, Florian Selt, Christel Herold-Mende, Olaf Witt, Till Milde, Stefan M Pfister, Andrey Korshunov, Marcel Kool
Journal: Neuro-Oncology (2017)

Embryonal tumor with multilayered rosettes (ETMR) is a rare and aggressive embryonal brain tumor that solely occurs in infants and young children and has only recently been recognized as a separate brain tumor entity in the World Health Organization classification for CNS tumors. Patients have a very dismal prognosis with a median survival of 12 months upon diagnosis despite aggressive treatment. The aim of this study was to develop novel treatment regimens in a preclinical drug screen in order to inform potentially more active clinical trial protocols. We have carried out an in vitro and in vivo drug screen using the ETMR cell line BT183 and its xenograft model. Furthermore, we have generated the first patient-derived xenograft (PDX) model for ETMR and evaluated our top drug candidates in an in vitro drug screen using this model. BT183 cells are very sensitive to the topoisomerase inhibitors topotecan and doxorubicin, to the epigenetic agents decitabine and panobinostat, to actinomycin D, and to targeted drugs such as the polo-like kinase 1 (PLK1) inhibitor volasertib, the aurora kinase A inhibitor alisertib, and the mammalian target of rapamycin (mTOR) inhibitor MLN0128. In xenograft mice, monotherapy with topotecan, volasertib, and actinomycin D led to a temporary response in tumor growth and a significant increase in survival. Finally, using multi-agent treatment regimens of topotecan or doxorubicin combined with methotrexate and vincristine, the response in tumor growth and survival was further increased compared with mice receiving single treatments. We have identified several promising candidates for combination therapies in future clinical trials for ETMR patients.
Pooled resistance analysis in HCV genotype 1–6-infected patients treated with glecaprevir/pibrentasvir in phase 2 and 3 clinical trials
Authors: P. Krishnan, G. Schnell, R. Tripathi, T. Ng, T. Reisch, J. Beyer, T. Dekhtyar, M. Irvin, W. Xie, L. Larsen, F. Mensa, T. Pilot-Matias, C. Collins
Journal: Journal of Hepatology (2017)
Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies
Authors: Gautam Goel, Tim King, A James Daveson, Jane M Andrews, Janakan Krishnarajah, Richard Krause, Gregor J E Brown, Ronald Fogel, Charles F Barish, Roger Epstein, Timothy P Kinney, Philip B Miner, Jason A Tye-Din, Adam Girardin, Juha Taavela, Alina Popp, John Sidney, Markku Mäki, Kaela E Goldstein, Patrick H Griffin, Suyue Wang, John L Dzuris, Leslie J Williams, Alessandro Sette, Ramnik J Xavier, Ludvig M Sollid, Bana Jabri, Robert P Anderson
Journal: The Lancet. Gastroenterology & hepatology (2017)