tbuckley/cabot-search huggingface dataset:
Clinical diagnostic utility of a blood-based multi-transcriptome assay for gastroenteropancreatic disease.
Authors: Irvin Mark Modlin, Daniele Alaimo, Stephen Callahan, Harry Aslanian, Christopher Lepensky, Nancy S. Teixeira, Lisa Bodei, Ignat Drozdov, Mark S. Kidd
Journal: Journal of Clinical Oncology (2015)

4106 Background: Current blood-based biomarkers for the diagnosis and follow-up of neuroendocrine tumors (NETs) do not achieve acceptable metrics of sensitivity and specificity. We report the sensitivity and selectivity of the PCR-based test, the NETest, to detect tumors with reference to other benign and malignant gastrointestinal diseases. We report the utility of a 51 transcript peripheral blood signature, the NETest, in comparison to Chromogranin A (CgA) measurement in pancreatic NETs. Methods: One hundred and seventy nine cases (Set 1: gastrointestinal tumors: n= 81 including NETs (n= 41) and gastrointestinal carcinomas (n= 40); Set 2: pancreatic disease: n= 98 including NETs (n= 45), pancreatitis (n= 4), cysts (n= 31) and adenocarcinoma (n= 14)) were prospectively collected and analyzed by the NETest (disease activity index > 20% [0-100 score]) or by chromogranin A (CgA) ELISA to determine metrics for detecting small intestinal and pancreatic NETs. Marker gene expression (qPCR) and CgA (DAKO) were compared (χ2, non-parametric) in Set 1. For Set 2, selectivity was assessed; sensitivity and specificity metrics were calculated for the entire cohort (n= 179). Results: Set 1: For intestinal disease, the accuracy of the NETest was 93% (all NETs positive, .CgA was positive in 80% but 29% (n= 7) of colorectal cancers were CgA positive and 3 (7.5%) colorectal tumors were NETest positive)). Set 2: For pancreatic disease, the NETest accuracy was 92% (96% NETs positive, 2 (6%) intraductal papillary mucinous neoplasms (IPMN) positive) while for CgA it was 56% (29% of pancreatic NETs were CgA positive). Overall, the NETest was significantly more sensitive than CgA for the detection of small intestinal (AUC 0.98±0.01 versus 0.75±0.06 p< 0.0001) and pancreatic NETs (0.95±0.02 vs. 0.5±0.06, p< 0.0001). When CgA was normal, The NETest was elevated (93%). Conclusions: This “real-world” study comparing NETs to unknown gastroenteropancreatic diseases demonstrates the sensitivity and specificity of a blood-based multianalyte NET gene transcript measurement for identifying small intestinal and pancreatic neuroendocrine tumor disease.
Vigilancia del botulismo transmitido por alimentos en Polonia: 1960-1998
Authors: A Galazka, A Przybylska
Journal: Eurosurveillance (1999)

El botulismo transmitido por alimentos, a diferencia de las otras dos formas de botulismo (por heridas e infantil), es una intoxicacion que aparece al ingerir toxina botulinica preformada. Los casos esporadicos y los brotes familiares y generales aparecen cuando los productos alimenticios se elaboran o conservan incorrectamente y se almacenan en condiciones anaerobias que permiten la germinacion y multiplicacion de las esporas y la produccion de toxina.
GW28-e1120 Six versus twelve mouths of dual antiplatelet therapy after implantation of biodegradable polymer sirolumus-eluting stent in patients with diabetes mellitus: A subgroup analysis of the I-LOVE-IT 2 Trial
Authors: Dan Xu, Yi Li, Jing Li, Heyang Wang, Yushan Chen, Yaling Han, Wang Shuang
Journal: Journal of the American College of Cardiology (2017)
A phase II clinical trial of radium-223 activity in patients (pts) with metastatic castration-resistant prostate cancer (mcrpc) with asymptomatic progression while on abiraterone acetate or enzalutamide besides AR-V7 mutational status (EXCAAPE)
Authors: J. Carles Galceran, T. Bonfill Abella, P. Borrega, R. Collado, J. Garde, M.A. Gonzalez del Alba Baamonde, E. Grande Pulido, B. Mellado, M.J. Mendez Vidal, J.M. Piulats Rodriguez, R. Morales Barrera, E. Gallardo Diaz, P. Paredes, C. Suarez Rodriguez, O. Reig, S. Vazquez Estevez
Journal: Annals of Oncology (2017)
Malignant pleural mesothelioma immune microenvironment and checkpoint expression before and after systemic cytotoxic treatment
Authors: G. Zago, F. Lunardi, F. Calabrese, S.E. Vuljan, L. Urso, S. Frega, A. Pavan, V. Polo, L. Bonanno, I. Attili, F. Rea, P.F. Conte, G. Pasello
Journal: Annals of Oncology (2017)
A Phase 1 PK/PD Study of ASN003, a novel highly selective BRAF and PI3K inhibitor, in patients with advanced solid tumors
Authors: D. Rasco, R. Sullivan, N. Lakhani, S. Reddy, N. Rao, L. Denis, A. Tolcher, K.T. Flaherty
Journal: Annals of Oncology (2017)
LKB1 loss is a novel genomic predictor of de novo resistance to PD-1/PD-L1 axis blockade in KRAS-mutant lung adenocarcinoma
Authors: F. Skoulidis, M.D. Hellman, M. Awad, J.F. Gainor, H. Rizvi, B. Carter, W.L. Denning, P. Villalobos, E.R. Parra, Y.Y. Elamin, J. Zhang, G.C. Leonardi, D.F. Halpenny, V. Papadimitrakopoulou, I.I. Wistuba, J.D. Wolchok, A.T. Shaw, P.A. Jänne, C.M. Rudin, J.V. Heymach
Journal: Annals of Oncology (2017)
Follicular lymphoma: clinical and mollecular characteristics of histologic transformation
Authors: M. Mendez Garcia, M. Sánchez-Beato Gomez, J. González Rincón, J. Gomez Codina, M. Llanos Rodríguez, A. Rueda Domínguez, C. Quero Blanco, L. De la Cruz Merino, J. Gumá Padró, M. Provencio Pulla
Journal: Annals of Oncology (2017)
Circulating levels of ADAM12, a stromal activation biomarker, are predictive of survival in pancreatic ductal adenocarcinoma (PDAC)
Authors: H.W. van Laarhoven, H. Damhofer, V.L. Veenstra, C. Waasdorp, L.B. van Rijssen, F. Dijk, J.W. Wilmink, M.G. Besselink, O.R. Busch, J.P. Medema, J. Shiansong Li, R. Jiang, D.W. Pierce, M.F. Bijlsma
Journal: Annals of Oncology (2017)
Systematic evaluation of the immune microenvironment of neuroendocrine tumours (NET)
Authors: C. Vesely, A. Childs, Y.N.S. Wong, O. Ogunbiyi, T.V. Luong, C. Thirlwell, M. Caplin, T. Marafioti, S. Quezada, T. Meyer
Journal: Annals of Oncology (2017)
Abstract 21: Remote Limb Ischemic Postconditioning Improves Postresuscitation Cerebrovascular Circulation and Survival/Neurological Prognoses via In Situ and Remote Activation of Akt-eNOS-NO Signaling Pathway
Authors: Wei-Tien Chang, Woan-Yi Wang, Chun-Pei Lee, Hsiao-Ching Wei, Sung-Chun Tang, Chien-Hua Huang, Min-Shan Tsai, Chih-Hung Wang, An-Yi Wang, Hsiao-Ju Cheng, Matthew Huei-Ming Ma, Cheng-Chung Fang, Shyr-Chyr Chen, Chiang-Ting Chien, Wen-Jone Chen
Journal: Circulation (2014)

Introduction: Cerebrovascular circulation is usually compromised after cardiac arrest and CPR. Remote limb ischemic post-conditioning (RLIP) is clinically feasible and can potentially mitigate post-resuscitation neurological deficits. Since nitric oxide (NO) is implicated in post-conditioning protection, we aim to investigate if RLIP impacts post-resuscitation cerebral perfusion and prognosis via NO-related mechanism. Hypothesis: RLIP improves post-CPR cerebral perfusion and prognosis through in situ and remote activation of Akt-eNOS-NO signaling. Methods: Using an established rat model of asphyxia cardiac arrest and CPR, we randomized the rats to the following groups: (1) sham, (2) standard CPR, (3) RLIP 5 min after return of spontaneous circulation (ROSC). RLIP was done by 3 cycles of 5 min of left hind limb ischemia followed by 5 min of reperfusion. Arterial blood was sampled for colorimetric determination of nitrate/nitrite. The cerebral perfusion was continuously recorded by OxyFLO probe. Two hours after ROSC, the brain and left femoral artery were harvested for measuring phosphorylated endothelial NO synthase (p-eNOS at Ser1177) and protein kinase B (p-Akt at Ser473). In a subgroup the survival and neurological outcomes were monitored up to 3 days. Results: The cerebral perfusion was significantly decreased (0.6-0.8 folds that of baseline) after ROSC in standard CPR group. If RLIP was employed, the cerebral perfusion was significantly augmented (up to 1.6 folds, P &lt; 0.001) in the post-resuscitation phase. This was associated with improved survival (log-rank P &lt; 0.05) and neurological scores at 6, 24, 48 and 72 h (all P &lt; 0.05). Plasma NO as indicated by nitrate/nitrite was significantly increased in the RLIP group ( P &lt; 0.05). Most of all, p-eNOS and p-Akt were significantly increased not only in left femoral artery but also in brain. If NOS inhibitor N ω -nitro-L-arginine methyl ester (10 mg/kg) was used, not only the NO increase was reversed, the improvement in survival and neurological outcomes were also abrogated. Conclusions: RLIP enhances post-resuscitation cerebral perfusion and improves survival and neurological prognoses not only via in situ limb artery derived NO but remote activation of Akt-eNOS signaling in the brain.
Reproductive function in patients (pts) with malignant ovarian germ cell tumors (MOGCT) following chemotherapy (ChT)
Authors: D. Chekini, A. Tryakin, M. Fedyanin, I. Pokataev, A. Bulanov, T. Zakharova, K. Zhordania, O. Sekhina, S. Tjulandin
Journal: Annals of Oncology (2017)
Versatile multigene expression biomarker for predicting clinical platinum sensitivity in non-small cell lung cancer (NSCLC) and ovarian cancer (OC).
Authors: Ida Kappel Buhl, Ib J. Christensen, Anker Hansen, Thomas Jensen, Ulla Hald Buhl, Nils Brunner, Mogens Winkel Madsen, Jens Benn Sørensen, Jesper Ravn, Eric Santoni-Rugiu, Jon Askaa, Peter Buhl Jensen, Steen Knudsen
Journal: Journal of Clinical Oncology (2015)

e18502 Background: There are no established biomarkers for prediction of clinical platinum sensitivity. A new platinum response prediction method using multigene expression is reported. Methods: We used a Drug Response Predictor (DRP) which is a microarray-based mRNA expression method previously described and validated (Wang et al JNCI 2013;105:1284–1291). The DRP combines in vitro sensitivity with baseline transcriptomics and is secondarily processed through mRNA expression patterns of more than 3.000 tumors in order to evaluate only the expressed genes of clinical relevance. Three datasets available through Gene Expression Omnibus were used: A) 133 NSCLC patients randomized to receive adjuvant chemotherapy containing platinum (n = 71) or no adjuvant treatment (n = 62) (GSE14814) (Zhu et al JCO 2010;28:4417-4424), B) 35 OC patients treated with a platinum (GSE9899) (Tothill et al Clin Cancer Res 2008 Aug 15;14(16):5198-208) and C) 28 OC patients treated with a platinum-containing regimen (GSE23554) (Marchion et al Clin Cancer Res 2011 Oct 1;17(19):6356-66) were examined with Affymetrix Human Genome U133A Array. Statistical analysis used the Cox-proportional hazards model and the studies were pooled using a random effects model. Results: The NSCLC study [2] demonstrated a hazard ratio (HR) (comparing the sensitive profile to the resistant) of 0.45 (95% CI: 0.19-1.05, p = 0.056). For the OC studies (Tothill et al; Marchion et al) the HRs were 0.80 (95% CI:0.36-1.78,p = 0.59) and 0.34 (95% CI:0.10-1.12, p = 0.074), respectively. The pooled HR was 0.50 (95 % CI 0.30-0.85, p = 0.010). Conclusions: When the smaller studies were pooled the mRNA profile significantly predicted the effect of platinum-based chemotherapy in NSCLC and OC (HR 0.50). This genomic platinum biomarker is currently being validated prospectively in breast cancer.
Final results of a phase I study of cabozantinib (cabo) plus nivolumab (nivo) and cabonivo plus ipilimumab (Ipi) in patients (pts) with metastatic urothelial carcinoma (mUC) and other genitourinary (GU) malignancies
Authors: R. Nadal, A. Mortazavi, M. Stein, S.K. Pal, N. Davarpanah, H.L. Parnes, Y.M. Ning, L.M. Cordes, J. Lin, M. Bagheri, L. Linderberg, M. Berniger, S.M. Steinberg, T. Moore, T. Lancaster, M. Aviles, R. Costello, D.P. Bottaro, W.L. Dahut, A.B. Apolo
Journal: Annals of Oncology (2017)
Overexpression of superoxide dimutase enhances the matrix metalloproteinase-2 expression and promotes an invasive phenotype in a dysplastic mouse prostate
Authors: Johny Elkahwaji, George Casale, Weixiong Zhong, George Hemstreet, Dali Huang, Jun Tian
Journal: Cancer Research (2007)

3079    Introduction and objective:  Epithelial to mesenchymal transition (EMT) and matrix metalloproteinase (MMP) play a major role in cell motility and remodeling process during cancer cell invasion. The imbalance between pro-and anti-oxidants have been shown to modulate the cellular morphology and the MMP activities during the invasive process in many human malignancies. The aim of this study was to evaluate the effect of chronic inflammation induced-oxidative stress on MMP activity and the molecular profile during EMT in a dysplastic mouse prostate.   Methods : Twelve weeks old male C3H/HeOuJ mice were anaesthetized with isoflurane and inoculated intraurethrally with 2x106  E.  coli  1677 bacteria. Control mice were inoculated with PBS. Mice were sacrificed at 26 weeks post-inoculation. Prostate tissue sections were stained with hematoxylin and eosin and evaluated by light microscopy for inflammatory responses and dysplastic changes. Expression of antioxidant, EMT marker, and proteolytic enzymes were analyzed by immunohistochemistry staining using antibodies against manganese superoxide dismutase (MnSOD), E-cadherin, and MMP-2, respectively.   Results : PBS control mice had no prostate infections or inflammation. All  E.  coli  infected mice had evidence of chronic prostatic inflammation with dense inflammatory infiltrates in the stroma. The prostatic glandular epithelium showed varying degrees of atypical hyperplasia with increased epithelial cell layers, cytological atypia, and dysplastic changes of glandular architecture. Prostatic gland exhibiting the dysplastic changes showed an overexpression of MnSOD, a decrease in E-cadherin, and an increased expression of MMP-2 as compared to PBS normal gland.   Conclusions : These data suggest that overexpression of MnSOD induced by chronic bacterial inflammation enhances the MMP-2 expression and modulates the profile of E-cadherin during the EMT process. Also, these results suggest that the increased level of intrinsic oxidative stress associated with both MMP-2 activation and down-regulation of E-cadherin expression might play a role in the invasive phenotype observed in the dysplastic mouse prostate.
Prediction of Mid-Term Outcomes in Adult Obstructive Hypertrophic Cardiomyopathy After Surgical Ventricular Septum Myectomy
Authors: Bing Tang, Yunhu Song, Hao Cui, Keshan Ji, Changsheng Zhu, Shihua Zhao, Xiaohong Huang, Qinjun Yu, Shengshou Hu, Shuiyun Wang
Journal: Journal of the American College of Cardiology (2017)
Head and neck cancer (HNC) and synchronic lung cancer: Impact of the lung cancer on the management and prognosis of these patients. Data from the SYNCHRON GFPC 15-04 Study
Authors: N. Paleiron, L. Saramon, G. Robinet, R. Gervais, P. Fournel, H. Le Caer, H. Berard, G. Valette, R. Marianowski, C. Chouaid
Journal: Annals of Oncology (2017)
Brote regional de S. Enteritidis fagotipo 5, con origen en una granja avícola en Austria
Authors: C Berghold, C. Kornschober, S. Weber
Journal: Eurosurveillance (2003)

En las temporadas de primavera y verano de 2002, el Nationale Referenzzentrale fur Salmonellen (Centro nacional de referencia de salmonelas - CNRS) de Austria observo un cluster de infecciones por Salmonella enterica subsp. enterica ser. Enteritidis fagotipo 5 humana (S. Enteritidis PT5) en dos distritos vecinos de este pais. Otro pequeno brote de infecciones por S. Enteritidis PT5 que se produjo en la misma region en 1999 fue vinculado a las aves de un productor de huevos local (unas 6.000 gallinas). Por lo tanto, la atencion se dirigio nuevamente a esta granja. Los resultados de los examenes bacteriologicos voluntarios de la granja y de otras investigaciones epidemiologicas identificaron al mismo productor como el origen del segundo brote. Los setenta aislamientos humanos de S. Enteritidis PT5 determinados en 2002 representaron una minoria de todas las infecciones. Cabe estimar que, durante el brote de 2002, se produjeron varios cientos de infecciones. El granjero no vacunaba a las nuevas aves contra la Salmonella desde agosto de 2001. Es probable que el cambio en la politica de vacunacion haya dado lugar a la reaparicion de infecciones por S. Enteritidis PT5. A finales de septiembre de 2002, el granjero dejo de vender huevos de mesa sin tratar. En octubre de 2002 solo se encontro un aislamiento de S. Enteritidis PT5 en toda la region.
Method for Case-Control Studies
Authors: S. Kibrick, M.D., A.D. Kelman, M.D., F. Moolten, M.D.
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Method for Case-Control Studies Get access S. Kibrick, M.D., S. Kibrick, M.D. 1Department of Microbiology Boston University School of MedicineBoston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar A.D. Kelman, M.D., A.D. Kelman, M.D. 1Department of Microbiology Boston University School of MedicineBoston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Moolten, M.D. F. Moolten, M.D. 1Department of Microbiology Boston University School of MedicineBoston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 48, Issue 5, May 1972, Page 1552, https://doi.org/10.1093/jnci/48.5.1552 Published: 01 May 1972
Oncological Home-Hospitalization: Prospective randomized trial to evaluate its implications for patient and society
Authors: L. Cool, J. Missiaen, P. Debruyne, K. Geldhof, T. Lefebvre, M. Desmedt, V. Foulon, H. Pottel, D. Vandijck, K. Van Eygen
Journal: Annals of Oncology (2017)
Explaining and apologizing to patients after errors does not increase lawsuits, finds study
Authors: Susan Mayor
Journal: BMJ (2017)

Explaining and apologizing to patients after a medical error has resulted in injury does not result in an increase in lawsuits, a large US study has reported.1

In the face of growing numbers of lawsuits, many US hospitals have introduced “communication and resolution” programs over the past few years. In these programs hospitals communicate with patients when adverse events have occurred, investigate and explain what happened, apologize where appropriate, and offer compensation where failure to follow standard procedures led to significant harm.

The study analyzed the documentation and outcomes for …
Abstract 18332: Clinical Parameters Associated with the Development of the Coronary Collateral Circulation in Patients with a Chronic Total Occlusion
Authors: Nina W van der Hoeven, Paul F Teunissen, Ronak Delewi, Stephan H Schirmer, Tobias Traupe, Tineke van der Pouw-Kraan, Jan P Tijssen, Jan J Piek, Gerard S Werner, Christian Seiler, Niels van Royen
Journal: Circulation (2012)

A well-developed collateral circulation provides a survival benefit in patients with obstructive coronary artery disease. Studies aiming to detect clinical parameters associated with collateral circulation show controversial results and have only been assessed in studies using angiographic assessment of the collateral circulation and mainly in patients with non-occlusive lesions. Here we assess the correlation of clinical parameters with intracoronary derived collateral flow index (CFI) a unique group of patients with a chronic total occlusion (CTO) in which was measured directly upon opening of the CTO. Data from 295 patients (Bern, Switzerland, Amsterdam, the Netherlands and Jena, Germany) were pooled. Clinical parameters and lab values were collected before the procedure. CFI was calculated from the occlusive pressure distal from the coronary lesion (Pd), the aortic pressure (Pao) and central venous pressure (CVP). Multivariate analysis was performed to assess the correlation between collateral formation and clinical parameters. The mean CFI was 0.39 ± 0.14. After multivariate analysis, β-blockers, hypertension and duration of AP were positively associated with a well-developed collateral circulation (respectively B=0.07, SE=0.03, p=0.02, B=0.040, SE=0.02, p=0.042 and B=0.001, SE=0.000, p=0.02). Furthermore, high serum leukocytes, prior MI and high diastolic blood pressure were negatively associated with a well-developed collateral circulation (respectively B=-0.01, SE=0.005, p=0.03, B=-0.04, SE=0.02, p=0.03 and B=-0.002, SE=0.001, p=0.011). In a unique cohort of CTO patients we show that high serum leukocytes and high diastolic blood pressure are associated with a poorly developed collateral circulation. Interestingly, the use of β-blockers is positively associated with a well developed collateral circulation, shedding new light on the potential mode of action of this drug in patients with angina pectoris.
Genome-wide methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol)
Authors: M. Gündert, D. Edelmann, A. Benner, L. Jansen, M. Jia, V. Walter, P. Knebel, E. Herpel, J. Chang-Claude, M. Hoffmeister, H. Brenner, B. Burwinkel
Journal: Annals of Oncology (2017)
Diagnostic accuracy of magnetic resonance imaging hepatic proton density fat fraction in pediatric nonalcoholic fatty liver disease
Authors: Michael S. Middleton, Mark L. Van Natta, Elhamy R. Heba, Adina Alazraki, Andrew T. Trout, Prakash Masand, Elizabeth M. Brunt, David E. Kleiner, Edward Doo, James Tonascia, Joel E. Lavine, Wei Shen, Gavin Hamilton, Jeffrey B. Schwimmer, Claude B. Sirlin
Journal: Hepatology (2017)

We assessed the performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in children to stratify hepatic steatosis grade before and after treatment in the Cysteamine Bitartrate Delayed‐Release for the Treatment of Nonalcoholic Fatty Liver Disease in Children (CyNCh) trial, using centrally scored histology as reference. Participants had multiecho 1.5 Tesla (T) or 3T MRI on scanners from three manufacturers. Of 169 enrolled children, 110 (65%) and 83 (49%) had MRI and liver biopsy at baseline and at end of treatment (EOT; 52 weeks), respectively. At baseline, 17% (19 of 110), 28% (31 of 110), and 55% (60 of 110) of liver biopsies showed grades 1, 2, and 3 histological steatosis; corresponding PDFF (mean ± SD) values were 10.9 ± 4.1%, 18.4 ± 6.2%, and 25.7 ± 9.7%, respectively. PDFF classified grade 1 versus 2‐3 and 1‐2 versus 3 steatosis with areas under receiving operator characteristic curves (AUROCs) of 0.87 (95% confidence interval [CI], 0.80, 0.94) and 0.79 (0.70, 0.87), respectively. PDFF cutoffs at 90% specificity were 17.5% for grades 2‐3 steatosis and 23.3% for grade 3 steatosis. At EOT, 47% (39 of 83), 41% (34 of 83), and 12% (10 of 83) of biopsies showed improved, unchanged, and worsened steatosis grade, respectively, with corresponding PDFF (mean ± SD) changes of –7.8 ± 6.3%, –1.2 ± 7.8%, and 4.9 ± 5.0%, respectively. PDFF change classified steatosis grade improvement and worsening with AUROCs (95% CIs) of 0.76 (0.66, 0.87) and 0.83 (0.73, 0.92), respectively. PDFF change cut‐off values at 90% specificity were –11.0% and +5.5% for improvement and worsening. Conclusion: MRI‐estimated PDFF has high diagnostic accuracy to both classify and predict histological steatosis grade and change in histological steatosis grade in children with NAFLD. (H epatology 2018;67:858–872)
GW28-e0452 All-trans retinoic acid may induce conotruncal cardiac defects in C57BL6J mice embryos and concentration gradient has effect on conotruncal defective phenotype
Authors: Qing Chu, Yu Nie, Shijun Gao, Haobin Jiang, Shengshou Hu
Journal: Journal of the American College of Cardiology (2017)
PACTO: A single center, randomized, phase II study of the combination of nab-paclitaxel and gemcitabine with or without tocilizumab, an IL-6R inhibitor, as first-line treatment in patients with locally advanced or metastatic pancreatic cancer
Authors: I. Chen, J.S. Johansen, T.A. Zimmers, C. Dehlendorff, V. Kirk Parner, B. Vittrup Jensen, D. Nielsen
Journal: Annals of Oncology (2017)