tbuckley/cabot-search huggingface dataset:
FRI0662 Assessment of bone density, structure, and cortical interruptions of finger joints in patients with rheumatoid arthritis using high-resolution peripheral quantitative ct
Authors: M Peters, A Scharmga, A van Tubergen, D Loeffen, R Weijers, B van Rietbergen, P Geusens, J van den Bergh
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Rheumatoid arthritis (RA) is characterized by peri-articular bone loss. In patients with RA, lower bone density and structural integrity, and an increased number of erosions compared to healthy controls (HCs) has been demonstrated using High-Resolution peripheral Quantitative CT (HR-pQCT) (1,2). To further characterize RA-related changes, we recently introduced a method for quantifying small cortical interruptions in finger joints (3). <h3>Objectives</h3> To investigate the cortical and trabecular bone density, structure, and cortical interruptions in MCP joints in early and late RA patients compared to HCs using HR-pQCT imaging. <h3>Methods</h3> The 2nd and 3rd MCP joint of 70 subjects (mean age 53.1 (SD 9.2) years) were evaluated by HR-pQCT (82μm isotropic voxel size): 38 HCs, 10 early RA (diagnosis ≤2 years ago) and 22 late RA (diagnosis ≥10 years ago). Images were analyzed for cortical interruptions, and for cortical and trabecular bone density and structure. Descriptives were analyzed per joint by one-way ANOVA with Bonferroni post-hoc testing or Kruskal-Wallis with Mann-Whitney post-hoc testing, as appropriate. <h3>Results</h3> Significant differences with respect to all parameters were found across the groups (Table 1). In early and late RA, the percentage of joints with at least 1 interruption was higher, and number of trabeculae, cortical thickness, total density and cortical density were lower than in HC. In addition, in late RA, number of interruptions, interruption volume and trabecular separation were higher, and trabecular density was lower than in HC. Bone loss at the cortical and trabecular bone was primarily observed at the rim of the joint (Figure 1, arrows). <h3>Conclusions</h3> Bone density and structural integrity were impaired in early and late RA patients compared to HCs whereas the number of cortical interruptions is increased. The assessment of such parameters using HR-pQCT is, therefore, a promising tool for the follow-up of bone involvement in MCP joints in patients with RA. <h3>References</h3> Fouque-Aubert et al., ARD 2010. Stach et al., A&amp;R 2010. Peters et al., ACR2016 (abstract). <h3>Disclosure of Interest</h3> M. Peters: None declared, A. Scharmga: None declared, A. van Tubergen: None declared, D. Loeffen: None declared, R. Weijers: None declared, B. van Rietbergen Consultant for: Scanco Medical AG, P. Geusens: None declared, J. van den Bergh: None declared
Abstract 16148: Human Cardiac Development and Function Requires Proper Distribution of Transcriptional Complexes
Authors: Yen-Sin Ang, Renee Rivas, Alexandre Ribeiro, Janell Rivera, Rohith Srivas, Karishma Pratt, Tamer Mohamed, Nicole Stone, Beth Pruitt, Michael Snyder, Deepak Srivastava
Journal: Circulation (2016)

Cell identity and function require accurate transcription factor localization and dysregulation of this process can result in human disease. Heterozygous mutations in GATA4, a cardiogenic transcrip...
AB0990 Peri-arteritis as a novel paraneoplastic presentation of myelodysplastic syndrome: a case series and review of the literature
Authors: N Droz, C Gota
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Myelodysplastic syndromes (MDS) are characterized by ineffective and dysplastic hematopoiesis resulting in peripheral blood cytopenias with varying risk for progression to acute myelogenous leukemia (AML)<sup>1</sup>. Autoimmune manifestations have been well described in association with MDS<sup>2</sup>. Peri-arteritis has rarely been reported. <h3>Objectives</h3> Here, we present a novel association of MDS with peri-arteritis. <h3>Methods</h3> Three patients within our institution and one in the literature were identified. Patients were diagnosed with MDS according to 2008 World Health Organization classification with concomitant occurrence of peri-arteritis on imaging<sup>3</sup>. <h3>Results</h3> See Table 1. <h3>Conclusions</h3> Autoimmune manifestations associated with MDS occur in 7–25% of patients. The most commonly reported conditions include vasculitis, inflammatory arthritis and connective tissue disease. There is a paucity of literature describing peri-arteritis associated with MDS<sup>2</sup>. Review of the literature revealed only one other case of peri-arteritis associated with MDS outside of those identified at our facility<sup>4.</sup> With this case series, we report peri-arteritis as a novel presentation of MDS. Peri-vascular inflammation may mimic idiopathic retroperitoneal fibrosis, however, persistent cytopenias, lack of response to immunosuppressive therapy and persistence of elevated inflammatory markers should prompt the physician to evaluate for an underlying diagnosis of MDS. <h3>References</h3> Ades L, Itzykson R, Fenaux P. Myelodysplastic Syndromes. Lancet. 2014;383(9936):2239–52. Mekinian A, Grignano E, Braun T et al. Systemic inflammatory and autoimmune manifestations associated with MDS. Rheumatology.2016;55(2):291–300. Swerdlow S, Campo E, Harris N et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2008. Inoue M, Kano T, Ozaki T et al. Rheumatic manifestations and an epipharyngeal mass accompanied by MDS. Mod Rheumatol. 2015;25(4):653–6. <h3>Disclosure of Interest</h3> None declared
Cost-effectiveness analysis of first-line treatments for early-stage, low-grade follicular lymphoma.
Authors: Joanna C. Yang, Elena B. Elkin, Rahul Parikh, Joachim Yahalom
Journal: Journal of Clinical Oncology (2017)

6619 Background: Low-grade follicular lymphoma (FL) can present as localized stage I to II disease in up to one-third of patients. Upfront involved-site radiation therapy (RT) to 24-30Gy is the preferred first-line management strategy for these patients. However, the National LymphoCare Study found that less than one quarter of patients with early-stage, low-grade FL received upfront RT, while more than half received either chemoimmunotherapy or observation. Methods: We performed a cost-effectiveness analysis using a Markov state-transition model to simulate the progression of early-stage, low-grade FL in a cohort of 60-year-old men. The following first-line treatments were compared: RT, observation, rituximab induction (RI), rituximab and bendamustine (BR), and rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP). Patients who relapsed received second-line therapies that were dependent on their first-line treatment: RT for RI and observation, RCHOP for RT and BR, and BR for RCHOP. Disease-progression probabilities and other model inputs were from published trials. Results: First-line RT followed by RCHOP for relapses had a quality-adjusted life expectancy (QALE) of 11.4 years, superior to first-line observation, RI, BR, and RCHOP strategies. First-line RT strongly dominated observation, BR, and RCHOP. Compared with RI, first-line RT resulted in an incremental cost-effectiveness ratio of $2,740 per quality-adjusted life year. The probability of dying from other causes, the probability of a complete response to RT, and the probability of relapse had the greatest impact on both cost and effectiveness expected values. Conclusions: In contrast to current practice patterns, first-line RT is the most effective upfront treatment for patients with early-stage, low-grade FL. Further, first-line RT paired with RCHOP for relapses is a cost-effective treatment paradigm, relative to other strategies. [Table: see text]
Long-term survival in oligometastatic head and neck cancer patients.
Authors: Jonathan Eric Leeman, Suchit H. Patel, Erik Steven Anderson, C. Jillian Tsai, Sean Matthew McBride, Lara Dunn, Eric Jeffrey Sherman, Nancy Y. Lee, Nadeem Riaz
Journal: Journal of Clinical Oncology (2017)

6029 Background: Aggressive therapies for patients with oligometastatic disease are increasingly being administered with definitive intent in the context of clinical trials. However, outcomes in oligometastatic head and neck squamous cell carcinoma (HNSCC) patients have not been well characterized. Methods: We reviewed outcomes from 1147 patients who received intensity modulated radiotherapy (IMRT) as part of definitive management for stage I-IVB HNSCC from 2001-2013 at our institution. The primary sites included oropharynx (n=735), oral cavity (OCC, n=182), larynx (n=180) and hypopharynx (n=50). Among patients who developed distant metastasis (DM), the the number of clinically or radiographically apparent tumors was assessed. Survival estimates following DM were generated using the Kaplan-Meier method and compared using log-rank testing. Cox proportional hazards models were used for univariate (UVA) and multivariate analyses (MVA). Results: A total of 148 (13%) patients developed DM at a median time of 10.7 months (range 0.3-81.2) after IMRT. The median follow-up time following DM was 48 months. 5-year survival following DM was significantly longer in patients with a solitary metastatic lesion compared to multiple lesions (table 1, p=0.001). Of the 19 patients with solitary metastasis, the 14 who received definitive local therapy with either surgery or radiation survived longer than those who did not (5-year survival 55.7% vs 0%, p=0.001), though patients who did not receive local therapy were of poorer performance status. On UVA and MVA, longer survival after DM was associated with presence of a solitary metastatic tumor (MVA hazard ratio 0.31, 95% CI 0.16-0.59, p=0.001). Conclusions: An oligometastatic phenotype characterizes HNSCC patients with solitary metastasis, especially when amenable to definitive local therapy. These findings have important implications regarding clinical trial design for HNSCC in the recurrent and oligometastatic setting. [Table: see text]
Efficacy of Carfilzomib (K), Pomalidomide (P), and Dexamethasone (d) in Heavily Pretreated Patients with Relapsed/ Refractory Multiple Myeloma (RRMM) in a Real World Setting
Authors: Miriam Hobbs, Jonas Paludo, Amie Fonder, Jithma P Abeykoon, Morie A. Gertz, S. Vincent Rajkumar, Ronald S. Go, Francis K Buadi, Martha Q. Lacy, Nelson Leung, Angela Dispenzieri, Wilson I Gonsalves, David Dingli, Yi L. Hwa, Taxiarchis Kourelis, Robert A. Kyle, Shaji Kumar, Prashant Kapoor
Journal: Blood (2016)
AB1076 Low back pain in turkish bus drivers: pilot study
Authors: ZB Karakoc, Z Sarı, F Koroglu, M Aamir RashediBonab, S Karakas, B Kapşigay
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Lowback pain is a common problem whichincreasefinancialburden of government (1).The incidence of back pain that can be seen in every part of society is also high in drivers (2). We haven9t seen any investigation about low back pain of Turkish drivers in literature. We thought that it should be research because of changeable ethnic differences. <h3>Objectives</h3> The aim of our study was to determine the rate of lowback pain and it9srelationshipbetweenquality of life in drivers. <h3>Methods</h3> Intercity and municipalitydriversof Istanbul and Yalova, participated in our study.Itwasdesigned as cross-sectional and complementarytype. Inclusioncriteriawerevolunteerforthis study and driving at least eight hours per day, being a driver for at least three years. Those with congenital deformities, having an accident history and doing an additional job were excluded from this study. After getting drivers9 demographic data, "Oswestry Low Back Disability Questionnaire" forlowback pain and "Nottingham Health Profile" forhealthquality of life weresurveyedface to face. Chi-square and Spearman9scorelationnon-parametric test in the SPSS statistics programwereusedforstatistical analysis in this study. <h3>Results</h3> All of the 261 people who participated in this study were male. Their mean of age, weekly working hours and working year were 43±9.28, 50±13.09 and 18±1.04, respectively. %50 of participantshavelowback pain and those of 43%reported that jobsatisfactionwasaffecteddue to pain. Itwasdetermined that 10% of participants, whosejobsatisfactionwereaffected, didn9tapply the medicaldoctor. While there was a significant relationship between low back pain and quality of life (p=0.000); there was no relationship between these two parameters and age and working year (p&gt;0.05). It was determined that applying to medical doctor (p=0.02) and drug use rate (p=0.015) increased if the painful period lasted longer. <h3>Conclusions</h3> Low back pain affects quality of life related to health status. In this study, it was seen that the incidence of low back pain was high in long-distance drivers and affected job satisfaction in a great way. We think that the rates of drug use and medication usage can be reduced by increasing leisure time activity before increasing the severity of back pain and lengthening painful period. In addition, half of this occupation group is influenced by low back pain and once again it has been shown that waist schools should be expanded in our country. <h3>References</h3> Hoy, D.,Brooks, P., Blyth, F., andBuchbinder, R. The Epidemiology of LowBack Pain. Best Practice andResearchClinicalRheumatology. 2010; 24(6): 769–781. Anderson, Robert. The Back Pain of Bus Drivers: Prevalencein an Urban Area of California. Spine. 1992; 17(12); 1481–1488. <h3>Disclosure of Interest</h3> None declared
AB0498 Soluble CD14 (PRESEPSIN) as a potential biomarker to discriminate infection vs. activity in patients with systemic lupus erythematosus
Authors: I Posso-Osorio, A Echeverry, D Aguirre-Valencia, G Castaño, G Tobόn
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Differentiation of Systemic Lupus Erythematosus (SLE) activity and infection in a febrile SLE patient become difficult, since initial clinical presentation may be similar. Several biological markers (including procalcitonin and CRP) have been evaluated, with discordant results. Soluble CD14 (sCD14), also called presepsin, is the receptor for lipopolysaccharide - lipopolysaccharide binding protein (LPS-LBP) complexes. CD14 could activate a series of signal transduction pathways and inflammatory cascades, and lead to systemic inflammatory responses.(1) <h3>Objectives</h3> The aim of this study is to evaluate the utility of sCD14 as a biomarker to differentiate infection <i>vs.</i> activity in SLE patients admitted with systemic inflammatory response (SIRS). <h3>Methods</h3> We included 11 patients with SLE (ACR criteria 1997) and SIRS (International conference 2001) admitted to the ER and/or ICU. The measurement of sCD14 in plasma by enzymatic immunoassay of chemiluminescence <i>in vitro</i> was performed to differentiate active SLE <i>vs.</i> infection. Infection was considered if a positive culture/PCR was obtained. Mann-Whitney test was used to evaluate the association of variables with infection. <h3>Results</h3> All patients were female; mean age 37.9 years. An infectious disease was confirmed in 5 cases (3 bacterial including urinary tract infection, pneumonia and bacteremia; 1 viral infection by Chikungunya virus and 1 fungal by <i>histoplasma capsulatum</i>). sCD14 was elevated in the infected SLE patients (median: 1005 pg/mL- RIC: 533–1415-) vs patients with lupus flare (median: 431.5 pg/mL - RIC: 369–579-) (p=0,04). <h3>Conclusions</h3> High values of sCD14 levels seem to be useful to differentiate infections from activity in SLE patients with SIRS. More patients and further analysis are necessary to define the clinical use of this biomarker. <h3>References</h3> Zou Q, Wen W, Zhang X. Presepsin as a novel sepsis biomarker. World J Emerg Med [Internet]. Second Affiliated Hospital of Zhejiang University School of Medicine; 2014 Aug 22;5(1):16–9. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129857. <h3>Disclosure of Interest</h3> None declared
Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians
Authors: Sanja Stanojevic, Brian L. Graham, Brendan G. Cooper, Bruce R. Thompson, Kim W. Carter, Richard W. Francis, Graham L. Hall
Journal: European Respiratory Journal (2017)

There are numerous reference equations available for the single-breath transfer factor of the lung for carbon monoxide (T LCO); however, it is not always clear which reference set should be used in clinical practice. The aim of the study was to develop the Global Lung Function Initiative (GLI) all-age reference values for T LCOData from 19 centres in 14 countries were collected to define T LCO reference values. Similar to the GLI spirometry project, reference values were derived using the LMS (lambda, mu, sigma) method and the GAMLSS (generalised additive models for location, scale and shape) programme in R.12 660 T LCO measurements from asymptomatic, lifetime nonsmokers were submitted; 85% of the submitted data were from Caucasians. All data were uncorrected for haemoglobin concentration. Following adjustments for elevation above sea level, gas concentration and assumptions used for calculating the anatomic dead space volume, there was a high degree of overlap between the datasets. Reference values for Caucasians aged 5-85 years were derived for T LCO, transfer coefficient of the lung for carbon monoxide and alveolar volume.This is the largest collection of normative T LCO data, and the first global reference values available for T LCO.
SAT0298 Influence of age onset in clinical and biological spectrum of systemic lupus erythematosus
Authors: M Kechida, N Lorenzo, I Ben Chaaben, R Klii, S Hammami, I Khochtali
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a multi systemic auto immune disease which can affect patients at any age. <h3>Objectives</h3> We aimed to study influence of age onset in clinical and biological spectrum of SLE <h3>Methods</h3> medical records of 89 patients diagnosed as SLE according to the ACR criteria of 1997, between January 2004 and December 2016, were retrospectively analyzed. Patients were divided into 3 groups according to the age of onset: Juvenile onset patients (group 1) (G1) (≤16 years), Adult onset patients (group 2) (G2) (&gt;16 and &lt;50 years), Late onset patients (group 3) (G3) (≥50 years). Clinical and biological comparative study was conducted between the 3 groups. Data were analyzed by chi-square test and potentially associated factors were tested by binary logistic regression. <h3>Results</h3> among the patients 11.2% are in G1, 75.3% in G2 and 13.5% in G3. Prevalence of SLE was higher in female than male (F/M=9/1) but predominance of women was lower in G1 (F/M=4/1) compared to G2 (F/M=10/1) and G3 (F/M=11/1). Patients in G3 had more hypertension (41.7%) compared to G2 (6%) (p=0.5) and G1 (0%) (p=0.04). Vespertilio erythema was less frequently found in G3 (33.3%) compared to G2 (64.2%) (p=0.045) and G1 (80%) (p=0.04). Anti Sm antibodies were more frequent in G1 (87.5%) compared to G2 (38.5%) (p=0.009) and G3 (18.2%) (p=0.003). Multivariate analysis showed that hypertension is significantly associated to late onset lupus (OR=29, 95% IC= [2.77 – 320], p=0.05) and anti Sm antibody is more frequent in juvenile onset patients (OR=12, 95% IC= [1.4- 117], p=0.024). <h3>Conclusions</h3> according to our study, prevalence of lupus is higher in female regardless of age onset. Late onset lupus is associated to a high frequency of co morbidity while anti Sm antibody seems to be a hallmark of juvenile onset. <h3>Disclosure of Interest</h3> None declared
Abstract P118: Association of Comorbid Depression and Diabetes with Mortality: A Pooled Cohort Analysis
Authors: Mercedes R Carnethon, Peter John D De Chavez, Sherita H Golden, Brenda Campbell-Jenkins, Mary L Biggs, Tene T Lewis, Nefertiti Durant, Kiang Liu, Hillary Tindle, Alan R Dyer
Journal: Circulation (2013)

Background: Reports from prior studies testing whether adults with comorbid depression and diabetes have higher mortality than adults with diabetes alone are inconsistent. Explanations may include sample sizes, inadequate follow-up, or populations selected based on disease status (e.g., post- CHD). In a large sample of adults free from prevalent CHD, we tested whether the presence of depressive symptoms in persons with diabetes led to higher mortality than what would be expected by either condition alone. Methods: Participants from the Coronary Artery Risk Development in Young Adults Study, Cardiovascular Health Study, Framingham Offspring Study and Multi-Ethnic Study of Atherosclerosis longitudinal cohort studies who had measures available to determine diabetes, depression and mortality were included in the analysis (n=17,160). Diabetes was determined based on medication use or fasting glucose &gt; 126 mg/dL. Centers for Epidemiologic Studies Depression (CES-D) scores &gt; 16 (&gt; 8 short version) indicated high depressive symptoms. We tested whether comorbid depressive symptoms and diabetes exceeded what would be expected by the sum of the two conditions independently on the additive scale by calculating the Relative Excess Risk due to Interaction (RERI; &gt; 0 indicates interaction). Results: Crude mortality was highest in participants who had high depressive symptoms and diabetes, followed by participants who had diabetes and low depressive symptoms. Despite a significantly elevated adjusted hazard ratios (HR) comparing participants with diabetes who had high vs. low depressive symptoms, the RERI was 0.058 (95% confidence interval [CI]: -0.298, 0.413) indicating an absence of additive interaction. Findings were similar across strata by sex, age (&lt; 65, &gt;65), race (non-white vs. white) and education (&lt; high school vs. &gt; high school). Conclusions: While comorbid diabetes and depressive symptoms do not act synergistically to increase mortality, death rates are highest in this subgroup of participants.
Suboptimal Agreement Among Cytopathologists in Diagnosis of Malignancy Based on Endoscopic Ultrasound Needle Aspirates of Solid Pancreatic Lesions: A Validation Study
Authors: Carrie Marshall, Rawad Mounzer, Matt Hall, Violette Simon, Barbara Centeno, Katie Dennis, Jasreman Dhillon, Fang Fan, Laila Khazai, Jason Klapman, Srinadh Komanduri, Xiaoqi Lin, David Lu, Sanjana Mehrotra, V. Raman Muthusamy, Ritu Nayar, Ajit Paintal, Jianyu Rao, Sharon Sams, Janak Shah, Rabindra Watson, Amit Rastogi, Sachin Wani
Journal: Clinical Gastroenterology and Hepatology (2017)
Role of cardiopulmonary exercise testing in clinical stratification in heart failure. A position paper from the Committee on Exercise Physiology and Training of the Heart Failure Association of the European Society of Cardiology
Authors: Ugo Corrà, Pier Giuseppe Agostoni, Stefan D. Anker, Andrew J.S. Coats, Maria G. Crespo Leiro, Rudolph A. de Boer, Veli‐Pekka Harjola, Loreena Hill, Mitja Lainscak, Lars H. Lund, Marco Metra, Piotr Ponikowski, Jillian Riley, Petar M. Seferović, Massimo F. Piepoli
Journal: European Journal of Heart Failure (2017)