tbuckley/cabot-search huggingface dataset:
Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4 + T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals
Authors: Claudio Mauro, Joanne Smith, Danilo Cucchi, David Coe, Hongmei Fu, Fabrizia Bonacina, Andrea Baragetti, Gaia Cermenati, Donatella Caruso, Nico Mitro, Alberico L. Catapano, Enrico Ammirati, Maria P. Longhi, Klaus Okkenhaug, Giuseppe D. Norata, Federica M. Marelli-Berg
Journal: Cell Metabolism (2017)
Countering Low-Linear Energy Transfer (LET) and High-LET Radiation Exposure with Pro-Methyl Hoechst (PMH) and EUK-134 (Mg-Salen Complex): Radioprotection of Normal Human CD34+ Cells in a Simulated Deep Space Environment.
Authors: Gurudutta U. Gangenahalli, John M. Millholland, Anna Kalota, Paula Bennett, Betsy M. Sutherland, Alan M. Gewirtz
Journal: Blood (2004)
Complete Tumor Responses in Lymphoma Patients Who Receive Autologous Cytotoxic T Lymphocytes Targeting EBV Latent Membrane Proteins
Authors: Catherine M. Bollard, Maja Stanojevic, Ann M. Leen, Teresita Lopez, Andrea N. Sheehan, George Carrum, Hao Liu, Chung-Che Chang, Adrian P. Gee, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, Stephen Gottschalk
Journal: Blood (2008)
Privatized Pharmaceutical Innovation vs Access to Essential Medicines
Authors: Gian Luca Burci, Lawrence O. Gostin
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fruit Intake Significantly Reduces the Onset of Allergic Symptoms in Schoolchildren
Authors: Takashi Kusunoki, Jiro Takeuchi, Mio Sakuma, Takeshi Morimoto, Takahiro Yasumi, Ryuta Nishikomori, Akane Higashi, Toshio Heike
Journal: Journal of Allergy and Clinical Immunology (2017)
Glucocorticoid-Induced TNFR-Related Protein (GITR) Ligand Mediates Tumor Immunoediting in Chronic Lymphocytic Leukemia and Impairs Direct and Rituximab-Induced NK Cell Anti-Leukemia Reactivity.
Authors: Corina Buechele, Tina Baessler, Benjamin J Schmiedel, Lothar Kanz, Helmut R Salih
Journal: Blood (2009)
Sunitinib plus paclitaxel in patients with advanced esophageal cancer: A phase II study from the Hoosier Oncology Group.
Authors: J. M. Schmitt, S. R. Sommers, W. B. Fisher, R. H. Ansari, E. L. Robin, K. Koneru, J. W. McClean, Z. Liu, N. H. Hanna
Journal: Journal of Clinical Oncology (2011)

e14661 Background: Vascular endothelial growth factor (VEGF) is over expressed in 30-60% of pts with esophageal cancer, with high levels associated with poor prognosis. Sunitinib is a tyrosine kinase inhibitor targeting VEGF receptors (types 1-3). Taxanes have single-agent activity in esophageal cancer including anti-angiogenic properties. We studied the efficacy and tolerability of sunitinib and paclitaxel in pts with advanced esophageal cancer. Methods: The primary objective was to evaluate PFS at 24 weeks (goal improvement from 25% to 50%). Secondary objectives included evaluation of RR, OS, and toxicities. Eligible pts had metastatic or recurrent esophageal or GE junction carcinoma with a maximum of one prior chemotherapy regimen. Treatment included paclitaxel 90mg/m2 day 1, 8, 15 and Sunitinib 37.5mg orally daily. After 4 cycles, pts could remain on sunitinib until disease progression or severe toxicities developed. Results: 28 pts were enrolled at 6 centers. Median age was 59.5 years (range 40 -84 yrs). 54% were ECOG PS 0, 39% ECOG PS 1 and 7% ECOG PS 2. The 24 week PFS rate was 27% (90% CI: 13-45%). 3 of 23 evaluable pts had a response (1 CR and 2 PR). Median overall survival was 228 days (90% CI: 140-283 days). Grade 3/4 toxicities included: anemia (18%), leukopenia (14%), fatigue (11%), and neutropenia (11%). There were 4 grade 5 toxicities including: upper GI hemorrhage (n=2), GI /esophageal fistula (n=1), and unexplained death (n=1). Conclusions: Sunitinib + paclitaxel in patients with advanced esophageal or GE junction cancer does not appear to improve the 24 wk PFS rate compared to historical controls.
Full Donor Engraftment without Chronic GvHD Following HLA-Matched Sibling Donor Haemopoietic Stem Cell Transplantation for Diamond Blackfan Anaemia
Authors: Jayanthi Alamelu, Farah O’Boyle, Natalie Killeen, Helen New, Ayad Atra, Inderjeet Dokal, John Davis, Letizia Foroni, Richard M. Szydlo, Irene Roberts, Josu de la Fuente
Journal: Blood (2008)
Patient-Reported Outcomes and Quality of Life Improved with Fluticasone Propionate and Fluticasone Propionate/Salmeterol Multidose Dry Powder Inhalers Versus Placebo in Patients with Persistent Asthma
Authors: Gordon Raphael, Gloria Yiu, Anat Sakov, Siyu Liu, Cynthia Caracta
Journal: Journal of Allergy and Clinical Immunology (2017)
Alveolar Macrophages from House Dust Mite-Tolerant Mice Induce Foxp3+ Regulatory T Cells in an IL-10-Independent Manner
Authors: Sonali J. Bracken, Alexander J. Adami, Linda A. Guernsey, Robert R. Clark, Evan R. Jellison, Craig R. Schramm, Roger S. Thrall
Journal: Journal of Allergy and Clinical Immunology (2017)
Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia
Authors: Katie L. Burnham, Emma E. Davenport, Jayachandran Radhakrishnan, Peter Humburg, Anthony C. Gordon, Paula Hutton, Eduardo Svoren-Jabalera, Christopher Garrard, Adrian V. S. Hill, Charles J. Hinds, Julian C. Knight
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Heterogeneity in the septic response has hindered efforts to understand pathophysiology and develop targeted therapies. Source of infection, with different causative organisms and temporal changes, might influence this heterogeneity.To investigate individual and temporal variations in the transcriptomic response to sepsis due to fecal peritonitis, and to compare these with the same parameters in community-acquired pneumonia.We performed genome-wide gene expression profiling in peripheral blood leukocytes of adult patients admitted to intensive care with sepsis due to fecal peritonitis (n = 117) or community-acquired pneumonia (n = 126), and of control subjects without sepsis (n = 10).A substantial portion of the transcribed genome (18%) was differentially expressed compared with that of control subjects, independent of source of infection, with eukaryotic initiation factor 2 signaling being the most enriched canonical pathway. We identified two sepsis response signature (SRS) subgroups in fecal peritonitis associated with early mortality (P = 0.01; hazard ratio, 4.78). We defined gene sets predictive of SRS group, and serial sampling demonstrated that subgroup membership is dynamic during intensive care unit admission. We found that SRS is the major predictor of transcriptomic variation; a small number of genes (n = 263) were differentially regulated according to the source of infection, enriched for IFN signaling and antigen presentation. We define temporal changes in gene expression from disease onset involving phagosome formation as well as natural killer cell and IL-3 signaling.The majority of the sepsis transcriptomic response is independent of the source of infection and includes signatures reflecting immune response state and prognosis. A modest number of genes show evidence of specificity. Our findings highlight opportunities for patient stratification and precision medicine in sepsis.
Adherence to head and neck cancer guidelines: Setting the stage for continual quality improvement.
Authors: Zhannat Nurgalieva, Randal S. Weber, Stephen Yenzen Lai, Erich M. Sturgis, Beth Michelle Beadle, William William, Carol M. Lewis
Journal: Journal of Clinical Oncology (2012)

193 Background: Adherence to clinical guidelines, such as those developed by the National Comprehensive Cancer Network (NCCN), can serve as a quality measure for delivered care. We aimed to assess multidisciplinary conference (MC) treatment recommendations’ adherence to NCCN head and neck cancer guidelines, while identifying potential areas for quality improvement. Methods: Patients presented with previously un-treated head and neck cancers are being prospectively accrued as they are presented at weekly MC. The charts of patients presented between 10/20/2011 and 6/31/2012 were retrospectively reviewed for clinical data leading up to MC to allow us to assess whether, based on the available information, the recommendations of conference are compliant with NCCN treatment guidelines. Results: We identified 231 eligible patients. TNM staging was documented in 90.9% of MC notes and treatment recommendations were documented for 93.5% of patients; the remainder of presented patients required further evaluation before a treatment plan could be determined. Of 196 enrolled patients, 53% had oropharyngeal cancer, 25% had oral cavity cancer, 18.4% had laryngeal cancer, and 3.6% had nasopharyngeal cancer. For the entire cohort, the mean age at presentation was 59.5 years. One hundred fifty nine patients (81.1%) were men. The recommendations of conference were compliant with NCCN treatment guidelines for 92.3% patients. The main reasons for non-compliance in 15 patients were treatment of T1/2N2 oropharyngeal cancer with definitive radiation alone (6 patients), incomplete documentation (4 patients), and recommended over-use of adjuvant therapy (3 patients) and induction chemotherapy (2 patients). Conclusions: NCCN guideline compliance can be used to evaluate the quality of head and neck cancer care. Although most cases involving deviation resulted from incomplete MC documentation, areas for improvement were identified. Further study is needed to evaluate how care that deviates from NCCN guidelines affects patient outcomes.
Modified Oral Rapid Drug Desensitization (ORDD) to Ibrutinib in a Patient with Stage IV Mantle Cell Lymphoma and Early Onset Grade 1 Hypersensitivity Reaction
Authors: Elena E. Perez, Mark R. Stein, Alan Koterba, Bruce Moskowitz, Neal E. Rothschild
Journal: Journal of Allergy and Clinical Immunology (2017)
Disruption of Tet2 Leads to Enhanced Self-Renewal and Competitive Repopulating Capacity of Fetal Liver Hematopoietic Stem Cells
Authors: Hiroyoshi Kunimoto, Yumi Fukuchi, Masatoshi Sakurai, Ken Sadahira, Yasuo Ikeda, Shinichiro Okamoto, Hideaki Nakajima
Journal: Blood (2011)
The activation of transient receptor potential melastatin 8 (TRPM8) receptors induces airway inflammation in bronchial asthma
Authors: Joo-Hee Kim, Young-Sook Jang, Ji Young Park, Yong Il Hwang, Sunghoon Park, Seung-Hun Jang, Ki-Suck Jung, Hae-Sim Park
Journal: Journal of Allergy and Clinical Immunology (2017)
Risk of Thromboembolic Events in ET and Early/Prefibrotic PMF: The Relevance of an Accurate Histological Diagnosis
Authors: Serena Rupoli, Gaia Goteri, Picardi Picardi, Lucia Canafoglia, Giorgia Micucci, Anna Rita Scortechini, Irene Federici, Federica Giantomassi, Lidia Da Lio, Antonio Zizzi, Pietro Leoni
Journal: Blood (2012)
Predicting patterns of distress in adult survivors of childhood cancer: A latent profile analysis from the Childhood Cancer Survivor Study.
Authors: Norma Mammone D'Agostino, Kim Edelstein, Nan Zhang, Christopher J. Recklitis, Tara M. Brinkman, Deokumar Srivastava, Wendy M. Leisenring, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Krull
Journal: Journal of Clinical Oncology (2016)

210 Background: Although most survivors are emotionally healthy, subgroups report elevated or increasing distress over time. Distress often involves comorbid symptoms, which are difficult to treat. Predictors of comorbidity have not been examined in survivors. This study identifies patterns of distress and examines disease, treatment and demographic predictors in long-term survivors diagnosed between 1970-99. Methods: Latent profile analyses were used to identify clusters of survivors (N = 16079) and siblings (N = 3085) based on symptoms of somatization, anxiety, and depression from the Brief Symptom Inventory – 18. Bayesian information criterion &amp; Lo-Mendell-Rubin adjusted likelihood ratio test were used to select cluster number. Multinomial logistic regression was used to identify predictors of cluster membership stratified by sex. Results: Four clusters were identified: low distress on all subscales (asymptomatic); high distress on all subscales (global distress); primary somatization (somatic distress); primary depression (affective distress). Compared to siblings, fewer survivors were asymptomatic (62% v. 74%) and more had global distress (11% v. 5%), p’s &lt; 0.0001. More male (66%) than female (58%) survivors were asymptomatic, and more females reported somatic (17% vs 10%) and global (12% vs 9%) distress, all p’s &lt; 0.0001. Among females, fair/poor perceived health (OR 30.9, 95% CI 19.4-49.1); pain (OR 3.4, 95% CI 2.4-4.8), divorced/separated (OR 2.3, 95% CI 1.7-3), less than college education (OR 1.9, 95% CI 1.5-2.3), and antimetabolite therapy (OR 1.3, 95% CI 1.1-1.6) were associated with global distress. Fair/poor perceived health (OR 26.2, 95% CI 17.6-38.9), pain (OR 5.1, 95% CI 3.8- 6.8), divorced/separated (OR 3.0, 95% CI 2.2-4), and anthracycline therapy (OR 1.2, 95% CI 1.0-1.4) were associated with global distress in males. Diagnosis, age at or time since diagnosis, and radiation were not significant predictors. Conclusions: Results support the conceptual distinction between somatic versus affective symptoms of distress and highlight sex differences and health-related predictors of distress, all which have implications for treatment approaches.
ACTR-38. NRG/RTOG 1119: PHASE II RANDOMIZED STUDY OF WHOLE BRAIN RADIOTHERAPY WITH CONCURRENT LAPATINIB IN PATIENTS WITH BRAIN METASTASIS FROM Her2-POSITIVE BREAST CANCER: A COLLABORATIVE STUDY OF NRG AND KROG (NCT01622868)
Authors: David M. Peereboom, Jennifer Moughan, In Ah Kim, Jennifer F. Delossantos, Paul W. Sperduto, Julia R. White, Minesh P. Mehta
Journal: Neuro-Oncology (2016)

The addition of trastuzumab to cytotoxic chemotherapy has improved outcomes for patients with HER2 positive breast cancer. Increased survival coupled with limited blood-brain barrier (BBB) penetration of trastuzumab may contribute to the increased incidence of brain metastasis in these patients. Half of these patients die of intracranial disease progression rather than extracranial disease. Therefore, strategies to improve survival must include increased CNS disease control in these patients. Lapatinib crosses the BBB and demonstrates modest activity against intracranial metastases. Based upon preclinical data and results of a phase I study, we hypothesized that lapatinib plus WBRT can improve the intracranial disease control compared to WBRT alone. A randomized phase II trial of WBRT (37.5 Gy/3 weeks) with or without concurrent lapatinib (1000 mg qd x 21 during WBRT and for 21 days after) was initiated. Non-CNS penetrating HER2 targeted therapy is permitted throughout the study, but patients not on trastuzumab, pertuzumab or any other breast cancer therapy at registration are not permitted to begin this therapy while on protocol treatment, but may begin it 24 hours after completion of protocol treatment. Eligibility includes HER2+ breast cancer with at least one measurable, unirradiated parenchymal brain metastasis. The two populations targeted for accrual include patients with 1) newly diagnosed, multiple brain metastases or 2) progressive brain metastases after stereotactic radiosurgery (SRS) or surgical resection of 1–3 metastases. Prior lapatinib is allowed. Patients are stratified by breast-specific graded prognostic assessment; use of non-CNS penetrating HER2 targeted therapy; and prior SRS or surgical resection. The primary endpoint is CR rate in the brain 12 weeks after WBRT. 85 of 143 target accrual have enrolled (5/31/2016). An amendment to allow protocol RT to be delivered as WBRT or SRS is in process. (Supported by NCI U10 grants CA21661, CA180868, CA180822, CA37422 & UG1CA189867).
Safety to Extensively Heated Cow's Milk Challenge in Children with Severe Cow's Milk Allergy
Authors: Pablo Torres Córdova, Natalia Falci Pedroso, Marcella Fonseca Mello, Patricia Salles-Cunha, Jorge Kalil, Fabio M. Castro, Ariana Campos Yang
Journal: Journal of Allergy and Clinical Immunology (2017)
Empowerment in adolescents and young adults (AYA) with cancer and its association with health-related quality of life
Authors: S. Kaal, O. Husson, S. van Duivenboden, R. Jansen, E. Manten-Horst, S. van den Berg, J.B. Prins, W.T. van der Graaf
Journal: Annals of Oncology (2016)
Overexpression of MEL1 as a Novel Fusion Partner of AML1 in the Blastic Phase of Chronic Myeloid Leukemia with the Recurrent Cryptic Translocation t(1;21)(p36.3;q22).
Authors: Sawcene Hazourli, Pierre Chagnon, Raouf Fetni, Lambert Busque, Josee Hebert
Journal: Blood (2005)
Low Incidence of Thromboembolism in Asian Multiple Myeloma Patients Treated with Thalidomide: Do We Really Need Prophylaxis for Thromboembolism in Asian Population?
Authors: Youngil Koh, Soo-Mee Bang, Jae Hoon Lee, Hwi-Joong Yoon, Young-Rok Do, Hun-Mo Ryoo, Nari Lee, Seok Jin Kim, Sung-Soo Yoon, Jong-Ho Won, Yeung-Chul Mun, Moon-Hee Lee, Jong-Youl Jin, Hyo-Jung Kim, HyeonSeok Eom, Min Kyoung Kim, Hyun Chun Shin, Korean Multiple Myeloma Working Party
Journal: Blood (2008)
Minimally Invasive Skin Tape Strip RNA-Seq Identifies Atopic Dermatitis Disease Endotype
Authors: Max A. Seibold, Elena Goleva, Nathan Dyjack, Byung Eui Kim, Brittany N. Richers, Clifton F. Hall, Agata Wesolowska-Andersen, Cydney Rios, Caroline Bronchick, Patricia A. Taylor, Donald Y.M. Leung
Journal: Journal of Allergy and Clinical Immunology (2017)
Achievement of at least PR was a robust prognostic factor in patients with refractory/relapsed DLBCL
Authors: Yoshiharu Kusano, Yasuhito Terui, Masahiro Yokoyama, Noriko Nishimura, Yuko Mishima, Kyoko Ueda, Hideaki Nitta, Tadahiro Gunji, Norihito Inoue, Anna Takahashi, Kiyohiko Hatake
Journal: Annals of Oncology (2016)
IgA Hevylite® Test As a Surrogate to Serum Protein Electrophoresis (SPEP) or Nephelometry in the Management of IgA Myeloma
Authors: Eileen Mary Boyle, Philip Young, Helene Demarquette, Julie Gay, Houria Debarri, Sarah Bonnet, Charles Herbaux, Remy Dulery, Salomon Manier, Jean-Luc Faucompre, Frederic Combat, Annie Pietrantuono, Brigitte Onraed, Bernadette Hennache, Thierry Facon, Stephen J Harding, Xavier Leleu
Journal: Blood (2012)
Patients with FLT3/ITD AML May Benefit From Allogeneic Transplant In First Remission: Outcomes From a Consecutive Series of Patients at a Single Institution
Authors: Amy E. DeZern, Anthony Sung, Sharon Kim, Hua-Ling Tsai, Jeanne Kowalski, B. Douglas Smith, Judith E. Karp, Steven D. Gore, Ephraim Fuchs, Michael A McDevitt, Leo Luznik, Richard J. Jones, Mark J. Levis
Journal: Blood (2010)
Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results
Authors: Michael C. Heinrich, Cathryn Rankin, Charles D. Blanke, George D. Demetri, Ernest C. Borden, Christopher W. Ryan, Margaret von Mehren, Martin E. Blackstein, Dennis A. Priebat, William D. Tap, Robert G. Maki, Christopher L. Corless, Jonathan A. Fletcher, Kouros Owzar, John J. Crowley, Robert S. Benjamin, Laurence H. Baker
Journal: JAMA Oncology (2017)

After identification of activating mutations of the KIT gene in gastrointestinal stromal tumor (GIST)-the most common sarcomaof the gastrointestinal tract-a phase 2 study demonstrated efficacy of imatinib mesylate in patients with metastatic GIST harboring a KIT exon 11 mutation. Initial results of long-term follow-up have found a survival benefit in this subgroup of patients.
Heavy lifting and shift work are linked to reduced fertility
Authors: Jacqui Wise
Journal: BMJ (2017)

Women who do physically demanding jobs or who work shifts may have reduced fertility, research published in Occupational and Environmental Medicine has found.1

The Environment and Reproductive Health (EARTH) study found that heavy lifting at work and non-daytime work schedules were associated with poorer egg quality in women attending an academic fertility clinic.

The researchers examined the ovarian reserve of 473 women, measured by the number of remaining eggs and levels of follicle stimulating hormone. They also looked at the ovarian response—the number of mature eggs capable of developing …
One ACL injury is enough! Focus on female football players
Authors: Anne Fältström
Journal: British Journal of Sports Medicine (2017)

I investigated1 (i) factors that differ between females with an ACL reconstructed (ACLR) knee who return to football or not, (ii) functional performance between these females who returned to football and knee-healthy players, (iii) predictors for additional ACLR and (iv) patient-reported outcomes in patients with bilateral ACL injuries.

ACL rupture is a serious and common injury in football. Return to sport (RTS) is a common goal after an ACLR, but females RTS and to football specifically to a lower degree than do males.2 There is lack of knowledge about factors associated with return to football in females after ACLR.

A key dilemma is the high re-injury risk after ACLR in female football players.2 It …
Reduced-Intensity Conditioning with FBA/FBAA Regimen Is Feasible for Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML): Interim Results of a Multicenter Clinical Trial in China.
Authors: Jianmin Wang, Jiong Hu, Chun Wang, Xinghua Chen, Jian Hou, Weiping Zhang, Wei Tang, Shike Yan, Xi Zhang, Lili Zhou, Jun Hou
Journal: Blood (2009)
Inhalational exposure to statins and drug vehicle induces transient immunological changes in both the airways and peripheral blood of non-human primates
Authors: Sarah Killingbeck, Sean Ott, Moyar Qing Ge, Cameron H. Flayer, Lisa Miller, Melpo Christofidou-Solomidou, Amir A. Zeki, Angela Haczku
Journal: Journal of Allergy and Clinical Immunology (2017)