Risk for Arterial and Venous Thrombosis in Patients With Myeloproliferative Neoplasms
Authors: Jie V. Zhao, C. Mary Schooling
Journal: Annals of Internal Medicine (2018)

Letters21 August 2018Risk for Arterial and Venous Thrombosis in Patients With Myeloproliferative NeoplasmsJie V. Zhao, PhD and C. Mary Schooling, PhDJie V. Zhao, PhDThe University of Hong Kong, Hong Kong, China (J.V.Z.)Search for more papers by this author and C. Mary Schooling, PhDCity University of New York, New York, New York (C.M.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0244 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hultcrantz and colleagues (1) show that myeloproliferative neoplasms (MPNs) with subtypes of polycythemia vera, essential thrombocythemia, and myelofibrosis that result in overproduction of erythrocytes, platelets, or other blood cell traits are associated with a higher risk for arterial and venous thrombosis. This finding is consistent with that from a randomized controlled trial showing that targeting a lower hematocrit level in polycythemia vera via phlebotomy and/or hydroxyurea treatment reduced cardiovascular and thrombotic events (2), although the exact mechanism was unclear. Of note, a recent Mendelian randomization study of 36 blood cell traits in ischemic heart disease (IHD), including ...References1. Hultcrantz M, Björkholm M, Dickman PW, Landgren O, Derolf ÅR, Kristinsson SY, et al. Risk for arterial and venous thrombosis in patients with myeloproliferative neoplasms: a population-based cohort study. Ann Intern Med. 2018;168:317-25. [PMID: 29335713]. doi:10.7326/M17-0028 LinkGoogle Scholar2. Marchioli R, Finazzi G, Specchia G, Cacciola R, Cavazzina R, Cilloni D, et al; CYTO-PV Collaborative Group. Cardiovascular events and intensity of treatment in polycythemia vera. N Engl J Med. 2013;368:22-33. [PMID: 23216616] doi:10.1056/NEJMoa1208500 CrossrefMedlineGoogle Scholar3. Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, et al. The allelic landscape of human blood cell trait variation and links to common complex disease. Cell. 2016;167:1415-29. [PMID: 27863252] doi:10.1016/j.cell.2016.10.042 CrossrefMedlineGoogle Scholar4. Kanias T, Sinchar D, Osei-Hwedieh D, Baust JJ, Jordan A, Zimring JC, et al. Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease. Transfusion. 2016;56:2571-83. [PMID: 27507802] doi:10.1111/trf.13745 CrossrefMedlineGoogle Scholar5. Schooling CM. Tachykinin neurokinin 3 receptor antagonists: a new treatment for cardiovascular disease? Lancet. 2017;390:709-11. [PMID: 28359648] doi:10.1016/S0140-6736(16)31648-8 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: The University of Hong Kong, Hong Kong, China (J.V.Z.)City University of New York, New York, New York (C.M.S.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0244. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRisk for Arterial and Venous Thrombosis in Patients With Myeloproliferative Neoplasms Malin Hultcrantz , Magnus Björkholm , Paul W. Dickman , Ola Landgren , Åsa R. Derolf , Sigurdur Y. Kristinsson , and Therese M.L. Andersson Risk for Arterial and Venous Thrombosis in Patients With Myeloproliferative Neoplasms Malin Hultcrantz , Magnus Björkholm , Ola Landgren , Sigurdur Y. Kristinsson , and Therese M.L. Andersson Metrics 21 August 2018Volume 169, Issue 4Page: 267-268KeywordsBlood cellsCardiovascular therapyHematocritPlateletsPolycythemia veraReticulocytesSex hormonesStatinsThrombocytosisThrombosis ePublished: 21 August 2018 Issue Published: 21 August 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...