tbuckley/cabot-search huggingface dataset:
High hepatic tumor burden and cardiovascular comorbidities linked to carcinoid heart disease
Authors: M.C. Mesquita, C.A.C. Silva, C.M.P.D.C. Silva, M.C. Feres Almeida Soeiro, L.A. Hajjar, P.M. Gehm Hoff, R.S.P. Riechelmann
Journal: Annals of Oncology (2017)
Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazole-controlled non-inferiority and single-blind extension study
Authors: Yuji Mizokami, Kazunori Oda, Nobuo Funao, Akira Nishimura, Satoshi Soen, Takashi Kawai, Kiyoshi Ashida, Kentaro Sugano
Journal: Gut (2017)

Objective To assess the non-inferiority of vonoprazan to lansoprazole for secondary prevention of non-steroidal anti-inflammatory drug (NSAID)-induced peptic ulcer (PU) and the safety of vonoprazan during extended use. Design A phase 3, 24-week, multicenter, randomised, double-blind (DB), active-controlled study, followed by a phase 3, ≥28 week, multicenter, single-blind, parallel-group extension study (EXT) in outpatients (n=642) receiving long-term NSAID therapy who are at risk of PU recurrence. The patients received vonoprazan (10 mg or 20 mg) or lansoprazole 15 mg once daily. For DB, non-inferiority of the proportion of patients with recurrent PU within 24 weeks was analysed by Farrington and Manning test (significance level 2.5%, non-inferiority margin 8.3%; primary endpoint), recurrent PU within 12 weeks, bleeding and time-to-event of PU (secondary endpoint) and treatment-emergent adverse events (TEAEs). For EXT, TEAEs (primary endpoint), recurrent PU and safety (secondary) were assessed up to 104 weeks for patients in the extension study. Results The non-inferiority of vonoprazan 10 mg and 20 mg to lansoprazole 15 mg was verified (percentage difference –2.2%,95% CI –6.2% to 1.8%, p&lt;0.001; –2.1%,95% CI –6.1% to 2.0%, p&lt;0.001, respectively). The proportion of patients with endoscopically confirmed recurrent PU within 24 weeks was 3.3%, 3.4% and 5.5%, for vonoprazan 10 mg, 20 mg and lansoprazole 15 mg, respectively. No significant safety concerns were identified. Conclusion The non-inferiority of vonoprazan (10 and 20 mg) was verified in patients receiving long-term NSAIDs in DB; it was effective and well tolerated in EXT for longer than 1 year, with a safety profile similar to lansoprazole (15 mg). Trial registration numbers NCT01452750 , NCT01456260 ; Results.
Randomized phase 2 study of PEGPH20 Plus nab-paclitaxel/gemcitabine (PAG) vs AG in patients (Pts) with untreated, metastatic pancreatic ductal adenocarcinoma (mPDA)
Authors: S.R. Hingorani, A. Bullock, T. Seery, L. Zheng, D. Sigal, P.S. Ritch, F.S. Braiteh, M. Zalupski, N. Bahary, W. Harris, J. Pu, C. Aldrich, S. Khelifa, W. Wu, D. Chondros, P. Jiang, A. Hendifar
Journal: Annals of Oncology (2017)
Patient preference between Cabazitaxel and Docetaxel for first-line chemotherapy in metastatic castrate-resistant prostate cancer (mCRPC): Results from the CABADOC randomized trial
Authors: K. Fizazi, R. Delva, G. Gravis, G. Baciarello, C. Theodore, M. Gross-Goupil, E. Bompas, F. Joly Lobbedez, Y. Tazi, T. L'Haridon, T. Nguyen Tan Hon, P. Barthelemy, S. Culine, J-F. Berdah, M. Deblock, P. Beuzeboc, A. Fléchon, C. Cheneau, G. Martineau, I. Borget
Journal: Annals of Oncology (2017)
Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial
Authors: Robert Coleman, Andrew Hall, Joan Albanell, Andrew Hanby, Richard Bell, David Cameron, David Dodwell, Helen Marshall, Joël Jean-Mairet, Juan-Carlos Tercero, Federico Rojo, Walter Gregory, Roger R Gomis
Journal: The Lancet Oncology (2017)
Presença endémica de Salmonela enterica do serotipo Cerro no sul de Itália
Authors: C Mammina, L Cannova, S CarfiPavia, A Nastasi
Journal: Eurosurveillance (2000)

A tipagem molecular de estirpes de salmonela isoladas, entre 1997 e 1999 no sul de Italia, realizada pelo Centro de Agentes Patogenicos Entericos do sul de Italia, demonstrou uma frequencia elevada de Salmonela enterica do serotipo Cerro. Este serotipo e extremamente raro em humanos, sendo o ribotipo rt2 largamente predominante. Os autores consideram a hipotese da disseminacao deste serotipo na Sicilia Oriental e recomendam uma vigilância cuidadosa A tipagem molecular de estirpes de salmonela isoladas, entre 1997 e 1999 no sul de Italia, realizada pelo Centro de Agentes Patogenicos Entericos do sul de Italia, demonstrou uma frequencia elevada de Salmonela enterica do serotipo Cerro. Este serotipo e extremamente raro em humanos, sendo o ribotipo rt2 largamente predominante. Os autores consideram a hipotese da disseminacao deste serotipo na Sicilia Oriental e recomendam uma vigilância cuidadosa.
Legacy data sharing to improve drug safety assessment: the eTOX project
Authors: Ferran Sanz, François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Montserrat Cases, Manuel Pastor, Philippe Marc, Joerg Wichard, Katharine Briggs, David K. Watson, Thomas Kleinöder, Chihae Yang, Alexander Amberg, Maria Beaumont, Anthony J. Brookes, Søren Brunak, Mark T. D. Cronin, Gerhard F. Ecker, Sylvia Escher, Nigel Greene, Antonio Guzmán, Anne Hersey, Pascale Jacques, Lieve Lammens, Jordi Mestres, Wolfgang Muster, Helle Northeved, Marc Pinches, Javier Saiz, Nicolas Sajot, Alfonso Valencia, Johan van der Lei, Nico P. E. Vermeulen, Esther Vock, Gerhard Wolber, Ismael Zamora
Journal: Nature Reviews Drug Discovery (2017)
Blinatumomab retreatment after relapse in patients with relapsed/refractory B-precursor acute lymphoblastic leukemia
Authors: M S Topp, M Stelljes, G Zugmaier, P Barnette, L T Heffner, T Trippett, J Duell, R C Bargou, C Holland, J E Benjamin, M Klinger, M R Litzow
Journal: Leukemia (2017)

Blinatumomab retreatment after relapse in patients with relapsed/refractory B-precursor acute lymphoblastic leukemia
How does academic achievement relate to cardiorespiratory fitness, self-reported physical activity and objectively reported physical activity: a systematic review in children and adolescents aged 6–18 years
Authors: Adilson Marques, Diana A Santos, Charles H Hillman, Luís B Sardinha
Journal: British Journal of Sports Medicine (2017)

Objective This report aimed to systematically review the evidence for a differential association between objective and self-reported physical activity and cardiorespiratory fitness on academic achievement. Design Systematic review. Data sources Studies were identified from searches in Embase, Education Resources Information Center, PubMed, PsycINFO, SPORTdiscus and Web of Science databases from January 2000 to December 2016. Eligibility criteria for selecting studies Eligibility criteria included cross-sectional, longitudinal and interventional study designs. Outcomes included students’ school grade or a standardised test or measure of academic achievement. Explanatory variables were cardiorespiratory fitness and objective and self-reported physical activity. Inclusion criteria included school-aged children and adolescents aged–18 years (or students from primary to secondary school when student’s participants age was not described) and articles published in English, Portuguese or Spanish. Results A total of 51 articles met inclusion criteria: 41 cross-sectional, 2 intervention and 8 longitudinal studies. Results from 11 studies were inconsistent regarding the relationship between objectively measured physical activity and academic achievement. Ten of the 16 articles reported positive associations between self-reported physical activity and academic achievement. From the 22 studies that analysed the relationship between cardiorespiratory fitness and academic achievement, it was verified that they all generally support the beneficial effect of cardiorespiratory fitness on students’ academic achievement. Conclusion Higher cardiorespiratory fitness may be important to enhance children and adolescents’ health and, additionally, academic achievement. Due to a lack of consensus across studies, methodological issues associated with the assessment of physical activity should be considered when investigating physical activity and academic achievement.
Non-Coding RNAs and Their Roles in Stress Response in Plants
Authors: Jingjing Wang, Xianwen Meng, Oxana B. Dobrovolskaya, Yuriy L. Orlov, Ming Chen
Journal: Genomics Proteomics & Bioinformatics (2017)

Abstract Eukaryotic genomes encode thousands of non-coding RNAs (ncRNAs), which play crucial roles in transcriptional and post-transcriptional regulation of gene expression. Accumulating evidence indicates that ncRNAs, especially microRNAs (miRNAs) and long ncRNAs (lncRNAs), have emerged as key regulatory molecules in plant stress responses. In this review, we have summarized the current progress on the understanding of plant miRNA and lncRNA identification, characteristics, bioinformatics tools, and resources, and provided examples of mechanisms of miRNA- and lncRNA-mediated plant stress tolerance.
Retreatment with direct-acting antivirals of genotypes 1-3-4 hepatitis C patients who failed an anti-NS5A regimen in real world
Authors: Philippe Halfon, Caroline Scholtès, Jacques Izopet, Sylvie Larrat, Pascale Trimoulet, Fabien Zoulim, Laurent Alric, Sophie Métivier, Vincent Leroy, Denis Ouzan, Victor de Lédinghen, Sofiane Mohamed, Guillaume Pénaranda, Hacène Khiri, Marie-Ange Thélu, Anne Plauzolles, Laurent Chiche, Marc Bourlière, Florence Abravanel
Journal: Journal of Hepatology (2017)
Colon cancer screening by fecal immunochemical testing in Iran
Authors: H. Salimzadeh, F. Bishehsari, C. Sauvaget, M. Amani, R. Hamzeloo, A. Nikfarjam, M. Maziar, S. Merat, A. Delavari, R. Malekzadeh
Journal: Annals of Oncology (2017)
Usefulness of electronic nose breath analyzer in patients with persistent rhinitis
Authors: T. Garriga-Baraut, J. Giner-Donaire, L. Soto-Retes, J. Montserrat-Gili, J. Gras-Cabrerizo, O. Sibila, E. Mateus-Medina, A. Crespo, J. Merino-Panades, Plaza
Journal: Allergy (2017)

Reference EPFL-CONF-231676View record in Web of Science Record created on 2017-10-09, modified on 2017-10-09
HELICS: um projecto europeu para normalizar a vigilância das infecções hospitalares, 1994-1995
Authors: R Mertens, J. M.J van den Berg, J Fabry, O. B Jepsen
Journal: Eurosurveillance (1996)

Durante a decada de 90, varios paises europeus iniciaram a criacao de re-des nacionais ou regionais para a vigilância das infeccoes hospitalares. A maior parte destas redes baseou-se no modelo do Sistema Nacional de Vigilância das Infeccoes Nosocomiais dos Centros de Controlo e Prevencao da Doenca (EUA), no projecto EURONIS, patrocinado pela UE, (Infeccoes Nosocomiais em Unidades de Cuidados Intensivos na Europa) ou na iniciativa DANOP/WHOCARE, coordenada pela OMS/EURO e pelo Statens Seruminstitut de Copenhaga.
Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo
Authors: Cedric N. Berger, Valerie F. Crepin, Theodoros I. Roumeliotis, James C. Wright, Danielle Carson, Meirav Pevsner-Fischer, R. Christopher D. Furniss, Gordon Dougan, Mally Dori-Bachash, Lu Yu, Abigail Clements, James W. Collins, Eran Elinav, Gerald J. Larrouy-Maumus, Jyoti S. Choudhary, Gad Frankel
Journal: Cell Metabolism (2017)
Dose- and regimen-dependent effects of dexamethasone on extracellular matrix of brain tissue
Authors: A.Y. Tsidulko, T.M. Pankova, C. Bezier, G. de La Bourdannaye, A.V. Suhovskih, G.M. Kazanskaya, S.V. Aidagulova, E. Grigorieva
Journal: Annals of Oncology (2017)
PRODIGE 51 - GASTFOX: Phase III randomised trial evaluating FOLFOX with or without DOCETAXEL (TFOX) as 1st line chemotherapy for locally advanced or metastatic oesophago-gastric adenocarcinoma
Authors: A. Zaanan, E. Samalin, C. Louvet, C. Montérymard, F. Khemissa, O. Bouche, S. Louafi, F. Ghiringhelli, P. Bernard, B. Chibaudel, P. Artru, Y. Molin, N. Baba-Hamed, O. Romano, T. Aparicio, P. Michel, P. Rougier, D. Tougeron, S. Manfredi, J. Taieb
Journal: Annals of Oncology (2017)
Ralph Josiah Patrick Wedgwood
Authors: Helen Chapel
Journal: BMJ (2017)

Ralph Josiah Patrick Wedgwood was born in Hendon, London, the second of the Hon Josiah Wedgwood and Dorothy Mary Winser, and brother of consultant physician John Wedgwood CBE (1919-2007). He moved to the US when his education at Bedales School was interrupted by the second world war, and he was evacuated by convoy to New England. After internship and paediatric residency at New York University, Bellevue Hospital, he returned to …
The Prognostic Significance of Polyclonal Bone Marrow Plasma Cells in Patients with Actively Relapsing Multiple Myeloma
Authors: Toshi Ghosh, Wilson I Gonsalves, Dragan Jevremovic, S. Vincent Rajkumar, Michael M. Timm, William Morice, Angela Dispenzieri, David Dingli, Prashant Kapoor, Taxiarchis Kourelis, Martha Q. Lacy, Suzanne R. Hayman, Francis K Buadi, Nelson Leung, Ronald S. Go, Yi Lin, Stephen J. Russell, John A Lust, Steven R. Zeldenrust, Rahma Warsame, Yi L. Hwa, Robert A. Kyle, Morie A. Gertz, Shaji Kumar
Journal: Blood (2016)
Wide-field endoscopic mucosal resection versus endoscopic submucosal dissection for laterally spreading colorectal lesions: a cost-effectiveness analysis
Authors: Farzan F Bahin, Steven J Heitman, Khalid N Rasouli, Hema Mahajan, Duncan McLeod, Eric Y T Lee, Stephen J Williams, Michael J Bourke
Journal: Gut (2017)

Objective To compare the cost-effectiveness of endoscopic submucosal dissection (ESD) and wide-field endoscopic mucosal resection (WF-EMR) for removing large sessile and laterally spreading colorectal lesions (LSLs) &gt;20 mm. Design An incremental cost-effectiveness analysis using a decision tree model was performed over an 18-month time horizon. The following strategies were compared: WF-EMR, universal ESD (U-ESD) and selective ESD (S-ESD) for lesions highly suspicious for containing submucosal invasive cancer (SMIC), with WF-EMR used for the remainder. Data from a large Western cohort and the literature were used to inform the model. Effectiveness was defined as the number of surgeries avoided per 1000 cases. Incremental costs per surgery avoided are presented. Sensitivity and scenario analyses were performed. Results 1723 lesions among 1765 patients were analysed. The prevalence of SMIC and low-risk-SMIC was 8.2% and 3.1%, respectively. Endoscopic lesion assessment for SMIC had a sensitivity and specificity of 34.9% and 98.4%, respectively. S-ESD was the least expensive strategy and was also more effective than WF-EMR by preventing 19 additional surgeries per 1000 cases. 43 ESD procedures would be required in an S-ESD strategy. U-ESD would prevent another 13 surgeries compared with S-ESD, at an incremental cost per surgery avoided of US$210 112. U-ESD was only cost-effective among higher risk rectal lesions. Conclusion S-ESD is the preferred treatment strategy. However, only 43 ESDs are required per 1000 LSLs. U-ESD cannot be justified beyond high-risk rectal lesions. WF-EMR remains an effective and safe treatment option for most LSLs. Trial registration number NCT02000141.
Serum CYFRA 21-1 as a biomarker of pemetrexed plus cisplatin treatment in nonsquamous non-small cell lung cancer.
Authors: Toshio Sakatani, Fumiyoshi Ohyanagi, Azusa Tanimoto, Yuko Kawano, Ryota Saito, Kyohei Kaburaki, Noriko Yanagitani, Keita Kudo, Atsushi Horiike, Sachiko Hagiwara, Takeshi Horai, Makoto Nishio
Journal: Journal of Clinical Oncology (2012)

e18014 Background: Pemetrexed (P) is a key drug in the treatment of advanced non-squamous (N-Sq) non-small cell lung cancer (NSCLC). Although differential efficacies of P between squamous (Sq) and N-sq subtypes have been reported, it is difficult to get a clear histological diagnosis from a small biopsy sample. Therefore, a more objective, yet simple, biomarker for histology-based treatment is needed. Previously, we reported that serum Cytokeratin fragment 21-1 (CYFRA) was related to the outcome of P monotherapy. In this study, we examined whether serum CYFRA could predict the efficacy of the cisplatin-pemetrexed (CP) combination regimen as well as it did for P monotherapy. Methods: Pre-treatment serum concentrations of CYFRA, carcinoembryonic antigen (CEA), squamous cell carcinoma (SCC) antigen, and sialyl Lewis X-I antigen (SLX) were measured in 50 N-sq NSCLC patients who were enrolled in a phase II study of C (75 mg/m 2 and 500 mg/m 2 ) against N-Sq NSCLC. Eligibility criteria consisted of histologically or cytologically confirmed recurrent or metastatic N-Sq NSCLC previously untreated with chemotherapy, ECOG performance status (PS) 0-1. The primary endpoint was response rate, which was evaluated with RECIST. The planned sample size was 50 patients. We analyzed possible associations between these NSCLC marker levels and the efficacy of the CP regimen. Results: From April 2010 to June 2011, 50 N-sq NSCLC patients (male/female, 34/16; median age 60 y (28-74 y)) were enrolled in this study. Patients’ histological characteristics were: adeno/large/not otherwise specified (NOS), 39/5/6; PS: 0/1, 31/19. In these 50 patients, elevated levels of serum CYFRA, CEA, SCC and SLX were found in 25, 32, 5 and 32 patients, respectively. CYFRA was significantly associated with progression-free survival (PFS) (median PFS: 5.53 vs. 3.29 months; p &lt; 0.05), whereas no significant associations were observed between PFS and CEA, SCC or SLX. In addition, multivariate analysis showed that higher CYFRA and PS levels were significant factors associated with a shorter PFS. (p &lt; 0.05) Conclusions: Serum CYFRA is related to the outcome of CP treatment; our results suggest that serum CYFRA is a promising predictive marker of CP therapy.
Sol Spiegelman 1914–1983
Authors: Jeffrey Schlom, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Sol Spiegelman 1914–1983 Get access Jeffrey Schlom, Ph.D. Jeffrey Schlom, Ph.D. Chief Laboratory of Tumor Immunology and Biology National Cancer Institute, Bethesda, Maryland 20205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 71, Issue 2, August 1983, Pages 227–228, https://doi.org/10.1093/jnci/71.2.227 Published: 01 August 1983
Abstract 12878: The Effect of Advanced Glycation End Products (AGE) Breaker, Alagebrium on the Cardiac Structural and Functional Change in Type I Diabetic Rat Model
Authors: Hye-Sun Seo, Nae-Hee Lee, Youn-Haeng Cho, Hyung Oh Choi, Jon Suh
Journal: Circulation (2015)

Background: Chronic hyperglycemia contributes to diabetic complications through the formation of advanced glycation end products (AGEs). The crosslink breaker, 3-phenacyl-4,5-dimethylthiazolium chloride (ALT-711), alagebrium chloride is known to reduce the pathological condition through breaking AGE cross-links. However, there has been little assessment regarding the impact of alagebrium on AGE-dependent signaling or restoring structural molecular physiology as well as the myocardial functional change. Methods: We investigated the effect of alagebrium on myocardial functional change using echocardiography as well as structural change in diabetic rat model based on the cellular mechanism. Results: AGE enhanced reactive oxygen species (ROS) synthesis dose-dependently in cardiomyocytes. Alagebrium induced decrease in enhanced ROS synthesis by AGE and increased expression of receptor for AGE (RAGE). In western blot and RT-PCR experiments, alagebrium also inhibited AGE-induced activation of MAP Kinase and decreased AGE-induced connective tissue growth factor (CTGF) and extracellular matrix. In echocardiography, the left ventricular (LV) dimension was increased (6.33 ±0.58mm at initial vs. 8.33±0.32mm at 16weeks after diabetes, p=0.003), and systolic contractility in radial and circumferential direction was decreased as diabetes was progressed in diabetic rat model. Diabetic progress also modified collagen structure. However, the alagebrium treatment reversed these LV remodeling (8.33±0.32mm at initial vs. 7.03±0.46mm at 4weeks after medication, p=0.049) and systolic dysfunction. The value of radial strain improved from 15.2±5.8% to 38.7±6.9% at 4weeks after medication. (p=0.032) Conclusion: In conclusion, alagebrium treatment in diabetic rat heart improved myocardial systolic dysfunction and LV remodeling by blocking the AGE-induced intracellular ROS synthesis resulting in inhibition of contractile dysfunction induced by AGE. The beneficial effect of alagebrium on diabetic cardiomyopathy was mediated by reduction of extracellular matrix production and this might be mediated by decreased activation of ERK (extracellular signal-regulated kinase) MAP kinase.
PROSENZA: Prospective multi-centre study of prognostic factors in castration resistant prostate cancer (CRPC) patients treated with enzalutamide (ENZ)
Authors: A. Medina, A. Montesa, N. Romero Laorden, E. Gonzalez-Billalabeitia, A. Rodriguez-Vida, G. Grau, T. Garcés, R. Morales Barrera, F.J. Vazquez Mazon, R. Villatoro, M.A. Gonzalez Del Alba Baamonde, F. López, S. Hernando Polo, M. Domenech, G. de Velasco, P. Borrega, R. Querol, E. Velez, E. Castro Marcos, D. Olmos Hidalgo
Journal: Annals of Oncology (2017)
GW28-e1153 Study of Intrinsic QRS Complex Duration Changes 6 Months After Cardiac Resynchronization Therapy
Authors: Rong Liu, Liang Yanchun, Yu Haibo, Xu Baige, Gao Yang, Yan Xiaolei, Xu Guoqing, Wang Na, Wang Zulu, Han Yaling, Wang Shuang
Journal: Journal of the American College of Cardiology (2017)
Prenatal and Postnatal PCB-153 and <i>p</i> , <i>p</i> ′-DDE Exposures and Behavior Scores at 5–9 Years of Age among Children in Greenland and Ukraine
Authors: Aske Hess Rosenquist, Birgit Bjerre Høyer, Jordi Julvez, Jordi Sunyer, Henning Sloth Pedersen, Virissa Lenters, Bo A.G. Jönsson, Jens Peter Bonde, Gunnar Toft
Journal: Environmental Health Perspectives (2017)

BACKGROUND: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior.OBJECTIVE: We investigated the association between prenatal and early-life exposures to 2,2 0 ,4,4 0 ,5,5 0 -hexachlorobiphenyl (PCB-153) and 1,1dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p 0 -DDE) and behaviors in children between 5 and 9 y of age.METHODS: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (n = 1,018), maternal serum PCB-153 and p,p 0 -DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model.Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score.RESULTS: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre-or postnatal exposures to PCB-153 or to p,p 0 -DDE.However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre-and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for preand postnatal p,p 0 -DDE, respectively.Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre-and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre-and postnatal p,p 0 -DDE, respectively.CONCLUSION: Prenatal and early postnatal exposures to p,p 0 -DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5-9 y of age in our study population.These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age.