tbuckley/cabot-search huggingface dataset:
Analisis de la persistencia de un marcador endoscopico para la identificación de localizaciones en el colon
Authors: S Ayllón Cano, M Megía Sánchez, A Zatarain Valles, S Fernández Díez, F Sánchez Ceballos, F González Rodríguez, M Vázquez Romero, E Rey Díaz-Rubio, JM Esteban López-Jamar
Journal: Endoscopy (2017)

La utilización de los marcadores endoscópicos ha servido para la localización quirúrgica de lesiones que requerían su extirpación pero también para localizar endoscópicamente zonas del colon donde se había realizado extirpación endoscópica de lesiones avanzadas para identificar crecimiento de lesiones en dicha zona. Mientras que en algunos países el marcaje se realiza con Tinta China, esta tiene serios inconvenientes y en España el mas utilizado es el SPOT. Se trata de una suspensión que contiene partículas de carbón altamente purificada.
Abstract 16951: Economic Burden of Angina and Chest Pain Following Percutaneous Coronary Intervention: a Real-World Analysis of Multi-Payer US Claims
Authors: Dhruv S Kazi, Ori Ben-Yehuda, Machaon Bonafede, John B Hernandez, Susanne F Machacz, Mark A Hlatky
Journal: Circulation (2014)

Background:  While PCI has revolutionized treatment of CHD, the contemporary incidence and economic burden of post-PCI angina and chest pain are not well documented. We sought to describe the direct medical costs associated with post-PCI angina/chest pain using real-world data.   Methods:  We used the multi-payer Truven Health MarketScan Commercial and Medicare Supplemental Databases to identify all patients undergoing a PCI (index event) between 2008 and 2011. We included all patients who had 12 months of continuous medical and pharmacy benefits before and after the index event. We identified outcomes of interest (angina, chest pain) using ICD-9 and CPT codes (inpatient claim with a principal diagnosis of angina or chest pain; an outpatient claim with an accompanying stress test or repeat PCI ≥ 30 days after the index PCI). Total and cardiovascular-specific costs were defined as the total paid amount on fully adjudicated claims in the first 12 months following the index PCI (2013 US$). We excluded patients with ACS from the cost analysis.   Results:  The 51,756 study patients who met the study criteria, had a mean age of 61.8 years, and 72% were men. In the first year after the index PCI, 23.1% had angina or chest pain, while only 2.7% had an ACS event. Compared with patients without an event, patients with post-PCI angina/chest pain had more hospitalizations (+0.5), clinic visits (+2.5), ER visits (+0.7), radiology services (+2.4), lab services (+6.1) and outpatient prescriptions (+5.8) (all p   Conclusions:  Despite continued improvement in CHD outcomes, persistent or recurrent angina and chest pain remain a clinical and economic burden in the first year after PCI. Strategies to reduce post-PCI angina/chest pain could have a substantial impact on the costs and outcomes of ischemic heart disease.
Designed trimer-mimetic TNF superfamily ligands on self-assembling nanocages
Authors: Minwoo Kih, Eun Jung Lee, Na Kyeong Lee, Yoon Kyoung Kim, Kyung Eun Lee, Cherlhyun Jeong, Yoosoo Yang, Dong-Hwee Kim, In-San Kim
Journal: Biomaterials (2018)
Abstract 19226: 2-Methoxyestradiol Down-regulates Angiotensin Type 1 Receptor Through G protein Coupled Receptor 30 Dependent Epidermal Growth Factor Receptor Phosphorylation at Tyrosine 1148
Authors: Benard Ogola, Yong Zhang, Thomas Thekkumkara
Journal: Circulation (2016)

The estrogen metabolite 2-methoxyestradiol (2ME2) elicits its pharmacological effects through G protein-coupled receptor 30 (GPR30), and has therapeutic potential in a number of cardiovascular diso...
Prótesis de aposición luminal en el tratamiento de estenosis esofágicas benignas. Serie de casos
Authors: M Fraile López, F Fernández Cadenas, MÁ De Jorge Turrión, OL González Bernardo, M Torner Simó, A Gómez Outomuro, MA Palacio Galán, O Castaño Fernández, R Fernández Velázquez, A Suárez González
Journal: Endoscopy (2017)

Las prótesis metálicas auto-expandibles (PMAC) han sido utilizadas para el tratamiento de estenosis refractarias, estando su eficacia limitada por altas tasas de migración o dificultad para extracción de las mismas. En estenosis esofágicas benignas cortas (EEBC) las prótesis de aposición luminal (PAL) tienen resultados prometedores al asociarse a menor migración y mayor facilidad de extracción.
Of Dictionaries, Old and New
Authors: Bergen Evans
Journal: JAMA (2023)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Weakly-supervised convolutional neural networks for multimodal image registration
Authors: Yipeng Hu, Marc Modat, Eli Gibson, Wenqi Li, Nooshin Ghavami, Ester Bonmati, Guotai Wang, Steven Bandula, Caroline M. Moore, Mark Emberton, Sébastien Ourselin, J. Alison Noble, Dean C. Barratt, Tom Vercauteren
Journal: Medical Image Analysis (2018)

One of the fundamental challenges in supervised learning for multimodal image registration is the lack of ground-truth for voxel-level spatial correspondence. This work describes a method to infer voxel-level transformation from higher-level correspondence information contained in anatomical labels. We argue that such labels are more reliable and practical to obtain for reference sets of image pairs than voxel-level correspondence. Typical anatomical labels of interest may include solid organs, vessels, ducts, structure boundaries and other subject-specific ad hoc landmarks. The proposed end-to-end convolutional neural network approach aims to predict displacement fields to align multiple labelled corresponding structures for individual image pairs during the training, while only unlabelled image pairs are used as the network input for inference. We highlight the versatility of the proposed strategy, for training, utilising diverse types of anatomical labels, which need not to be identifiable over all training image pairs. At inference, the resulting 3D deformable image registration algorithm runs in real-time and is fully-automated without requiring any anatomical labels or initialisation. Several network architecture variants are compared for registering T2-weighted magnetic resonance images and 3D transrectal ultrasound images from prostate cancer patients. A median target registration error of 3.6 mm on landmark centroids and a median Dice of 0.87 on prostate glands are achieved from cross-validation experiments, in which 108 pairs of multimodal images from 76 patients were tested with high-quality anatomical labels.
Kidney Cancer, Version 3.2015
Authors: Robert J. Motzer, Eric Jonasch, Neeraj Agarwal, Clair Beard, Sam Bhayani, Graeme B. Bolger, Sam S. Chang, Toni K. Choueiri, Brian A. Costello, Ithaar H. Derweesh, Shilpa Gupta, Steven L. Hancock, Jenny J. Kim, Timothy M. Kuzel, Elaine T. Lam, Clayton Lau, Ellis G. Levine, Daniel W. Lin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Elizabeth R. Plimack, Edward N. Rampersaud, Bruce G. Redman, Charles J. Ryan, Joel Sheinfeld, Brian Shuch, Kanishka Sircar, Brad Somer, Richard B. Wilder, Mary Dwyer, Rashmi Kumar
Journal: Journal of the National Comprehensive Cancer Network (2015)

The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for the clinical management of patients with clear cell and non-clear cell renal carcinoma. These NCCN Guidelines Insights highlight the recent updates/changes in these guidelines, and updates include axitinib as first-line treatment option for patients with clear cell renal carcinoma, new data to support pazopanib as subsequent therapy for patients with clear cell carcinoma after first-line treatment with another tyrosine kinase inhibitor, and guidelines for follow-up of patients with renal cell carcinoma.
Caring for Older People: Rehabilitation and older people
Authors: J. Young
Journal: BMJ (1996)

Risk factors in outbreaks of legionellosis * Water temperature between 200C and 500C * Nutrients available for growth, such as proteins and rust * Niches which will protect Legionella from heat and biocides, such as limescale and sludge * Fine (invisible) aerosol such as that generated from taps, shower heads, cooling towers, and spray humidifiers * Low water turnover-temperature may rise, biocides decay, and sediment precipitate to form a sludge * Open to ingress of animals, insects, dirt, and sun-direct sunlight encourages algal growth * Susceptible people exposed to aerosol-for example, those with impaired lung capacity or immune system Recommended further reading
Behind Schedule — Reconciling Federal and State Marijuana Policy
Authors: Rebecca L. Haffajee, Robert J. MacCoun, Michelle M. Mello
Journal: New England Journal of Medicine (2018)

Interview with Dr. Rebecca Haffajee on the conflict between federal and state marijuana laws. (09:40)Download As the marijuana-policy terrain in the United States shifts, it's important to consider the potential public health benefits of closing the divide between federal policies and those of individual states, which are increasingly legalizing at least medical marijuana use.
Abstract 11368: Pre-operative Endothelin Levels Predict Post-operative Acute Kidney Injury in Cardiac Surgery
Authors: Roxana Ghashghaei, Nick Wetterson, Joelle Coletta, Eugene Golts, Minal Patel, Elizabeth Lee, Paul Clopton, Ravinder Mehta, Alan S Maisel, Pam Taub
Journal: Circulation (2016)

Introduction: Acute kidney injury (AKI) occurs in up to 40% of patients undergoing cardiac surgery and is associated with substantial morbidity and mortality, prolonged hospitalizations, and increased costs. AKI is clinically characterized by by a rapid reduction in kidney function resulting in a failure to maintain fluid, electrolyte and acid-base homoeostasis. Thus, there is a critical need to identify patients at increased risk for developing AKI when undergoing cardiac surgery. Endothelin is a locally produced vasoactive and natriuretic peptide with pro-inflammatory and pro-fibrotic properties that serves an important role in the regulation of renal hemodynamics and hemofiltration. Hypothesis: In this study, we hypothesize that endothelin will predict post-operative AKI in patients undergoing cardiac surgery. Methods: 105 patients undergoing cardiac surgery (either coronary bypass surgery and/or valve surgery) were recruited from the Veterans Affairs San Diego Health Care System and their plasma samples pre-operatively and at 2, 6, 12, 24, and 48 hours post-operatively were collected. A post-hoc analysis was then performed to determine the ability of pre-operative endothelin levels to predict post-operative AKI. Results: Of 105 patients, 18 patients (17%) developed AKI post-operatively. Endothelin levels were elevated at baseline in patients who had a RIFLE score of at least 1, which is indicative of baseline renal injury. Preoperative endothelin was elevated in patients with post-operative AKI vs. no AKI (4.03 pg/mL [3.43-5.49] vs. 3.14 pg/mL [2.56-4.10], p=0.003). Interestingly, it was also determined that endothelin was superior to baseline creatinine in predicting AKI. Preoperative endothelin was predictive of post-operative AKI (AUC=0.721 (0.611-0.830), p=0.003) while there was no significant association between preoperative creatinine and post-operative AKI; p=0.953 (95% CI = 0.320-0.689). Conclusions: Elevation of pre-operative endothelin levels predicts post-operative AKI in patients undergoing cardiac surgery. Future studies are needed to understand mechanisms by which elevations in endothelin levels can predict future renal injury.
Clip OTSC (OVESCO), experiencia en un hospital de 3 ° nivel. análisis retrospectivo durante 4 años
Authors: JM Olmos Martínez, M Gonzalez Martínez, I Ezcurra Acedo, L Ciriano Hernández, C Magadán Álvarez, M Pascual Mato, C Del Pozo Calzada, Á Terán Lantarón, J Crespo García
Journal: Endoscopy (2017)

El clip OTSC (Over The Scope Clip), también conocido como OVESCO, se trata de un sistema capaz de aplicar una vez liberado una presión continua sobre el total del espesor de la mucosa.
Biosynthesis of Vasopressin In Vitro and Ultrastructure of a Bronchogenic Carcinoma
Authors: Jack M. George, Charles C. Capen, Audra S. Phillips
Journal: Journal of Clinical Investigation (1972)

Tumors from patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) have been found to contain large amounts of the antidiuretic hormone vasopressin. A lung tumor from a patient with hyponatremia most likely due to SIADH was removed at surgery and found to contain 23.5 mU vasopressin/g wet weight by radioimmunoassay Slices of this tumor were incubated with phenylalanine-(3)H. Arginine vasopressin-(3)H was purified from the incubate by Sephadex G-25 column chromatography in two different systems, performic acid oxidation, and gradient elution column chromatography with diethylaminoethyl Sephadex. As oxidation of vasopressin results in drastic conformational change with breaking of the ring of the cyclic polypeptide and addition of two cysteic acid residues per molecule, the radioactive material which eluted coincident with vasopressin both before and after this procedure was considered to be arginine vasopressin-(3)H. To our knowledge this is the first demonstration of in vitro biosynthesis of vasopressin by a tumor from a patient with SIADH.Ultrastructurally, the bronchogenic carcinoma was composed of small undifferentiated and granulated cells. The granulated neoplastic cells had well developed organelles (endoplasmic reticulum, free ribosomes) concerned with protein synthesis. Secretion granules present in the tumor cells were small, surrounded by a limiting membrane, and resembled those reported in polypeptide hormone-secreting cells.
UTILITY OF FAECAL OCCULT BLOOD TEST (FOBT) OUT OF COLORECTAL CANCER SCREENING PROGRAMME
Authors: L Rodríguez Martín, DJ Matias, L Monteserín Ron, S Vivas Alegre, R Díez Rodríguez, C Villar Lucas, R Quiñones Castro, MI Fernández, E Fernández Morán, F Jorquera Plaza
Journal: Endoscopy (2018)

Colorectal cancer screening (CRC) programmes with (FOBT) in asymptomatic patients between 50 and 69 years old have demonstrated to be effective in terms of reduction of incidence and mortality. There is very few information about the utility of this tests out of screening programmes. We aim to analyse the endoscopic findings in patients with positive FOBT out of screening programme.
The global impact of hand hygiene campaigning
Authors: C Kilpatrick, B Allegranzi, D Pittet
Journal: Eurosurveillance (2009)

Preview this article: The global impact of hand hygiene campaigning, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/14/17/art19191-en-1.gif
Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes
Authors: Andreas Heinzel, Michael Kammer, Gert Mayer, Roman Reindl-Schwaighofer, Karin Hu, Paul Perco, Susanne Eder, Laszlo Rosivall, Patrick B. Mark, Wenjun Ju, Matthias Kretzler, Peter Gilmour, Jonathan M. Wilson, Kevin L. Duffin, Moustafa Abdalla, Mark I. McCarthy, Georg Heinze, Hiddo L. Heerspink, Andrzej Wiecek, Maria F. Gomez, Rainer Oberbauer
Journal: Diabetes Care (2018)

OBJECTIVE The decline of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes is variable, and early interventions would likely be cost-effective. We elucidated the contribution of 17 plasma biomarkers to the prediction of eGFR loss on top of clinical risk factors. RESEARCH DESIGN AND METHODS We studied participants in PROVALID (PROspective cohort study in patients with type 2 diabetes mellitus for VALIDation of biomarkers), a prospective multinational cohort study of patients with type 2 diabetes and a follow-up of more than 24 months (n = 2,560; baseline median eGFR, 84 mL/min/1.73 m2; urine albumin-to-creatinine ratio, 8.1 mg/g). The 17 biomarkers were measured at baseline in 481 samples using Luminex and ELISA. The prediction of eGFR decline was evaluated by linear mixed modeling. RESULTS In univariable analyses, 9 of the 17 markers showed significant differences in median concentration between stable and fast-progressing patients. A linear mixed model for eGFR obtained by variable selection exhibited an adjusted R2 of 62%. A panel of 12 biomarkers was selected by the procedure and accounted for 34% of the total explained variability, of which 32% was due to 5 markers. The individual contribution of each biomarker to the prediction of eGFR decline on top of clinical predictors was generally low. When included into the model, baseline eGFR exhibited the largest explained variability of eGFR decline (R2 of 79%), and the contribution of each biomarker dropped below 1%. CONCLUSIONS In this longitudinal study of patients with type 2 diabetes and maintained eGFR at baseline, 12 of the 17 candidate biomarkers were associated with eGFR decline, but their predictive power was low.
Estudio comparativo a dos años entre gastroplastia plicada endoscópica vs. gastrectomía vertical y gastroplastia tubular plicada quirúrgica en pacientes obesos
Authors: J Nebreda Durán, E Espinet Coll, A García Ruiz De Gordejuela, G López-Nava Breviere, M Galvao Neto, J Pujol Gebelli
Journal: Endoscopy (2017)

Los procedimientos restrictivos, endoscópicos y quirúrgicos, son una excelente opción para el tratamiento de la obesidad en pacientes con IMC< 45 Kg/m2. Este estudio compara, por primera vez, un tratamiento endoscópico, Gastroplastia plicada endoscópica, método Apollo® (GPE) con tratamientos quirúrgicos, Gastrectomía vertical (GV) y Gastroplastia tubular plicada quirúrgica (GTP), a 2 años.
Pay GPs the same as hospitals to train medical students, says royal college
Authors: Abi Rimmer
Journal: BMJ (2018)

The Royal College of General Practitioners (RCGP) has written to the health secretary to demand an end to the inequality between the way that GP undergraduate training placements and hospital training placements are funded.

Helen Stokes-Lampard, chair of college, called for GP practices to get the same funding as hospitals for hosting medical students as part of their training.

The college said that …
GASTRIC ADENOCARCINOMA OF FUNDIC GLAND TYPE: CLINICOPATHOLOGICAL FEATURES DETERMINED BY RETROSPECTIVE ANALYSIS
Authors: S Shiroma, T Hirasawa, M Takamatsu, H Kawachi, S Yoshimizu, Y Horiuchi, A Ishiyama, T Yoshio, T Tsuchida, J Fujisaki
Journal: Endoscopy (2018)

Gastric adenocarcinoma of the fundic gland type (GAFG), chief cell predominant type, is a new histological type of gastric adenocarcinoma with chief cell differentiation. The aim of this study was to determine clinicopathological features of GAFG.
A NEW TUNNEL TECHNIQUE FOR THE ENDOSCOPIC TREATMENT OF ZENKER'S DIVERTICULUM
Authors: K Shishin, I Nedoluzhko, I Pavlov, N Kurushkina, L Shumkina
Journal: Endoscopy (2018)

Recently, the introduction of endoscopic technologies has resulted in the progression of surgical treatment options for Zenker's diverticulum. The endoscopic procedure's only drawback is the limitation in the ability to perform the longitudinal myotomy of the oesophagus. Currently, a new type of endoscopic intervention is being developed, which can provide access to the muscular wall of the oesophagus by forming a tunnel in the submucosal space.
Maintenance of CD4 T cell fitness through regulation of Foxo1
Authors: Ryan H. Newton, Sharad Shrestha, Jenna M. Sullivan, Kathleen B. Yates, Ewoud B. Compeer, Noga Ron-Harel, Bruce R. Blazar, Steven J. Bensinger, W. Nicholas Haining, Michael L. Dustin, Daniel J. Campbell, Hongbo Chi, Laurence A. Turka
Journal: Nature Immunology (2018)
REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort
Authors: Patricia Acosta-Castro, Camila Hirotsu, Helena Marti-Soler, Pedro Marques-Vidal, Nadia Tobback, Daniela Andries, Gérard Waeber, Martin Preisig, Peter Vollenweider, José Haba-Rubio, Raphael Heinzer
Journal: European Respiratory Journal (2018)

This study determined the prevalence of rapid eye movement (REM) related sleep-disordered breathing (REM-SDB) in the general population and investigated the associations of REM-SDB with hypertension, metabolic syndrome, diabetes and depression.Home polysomnography (PSG) recordings (n=2074) from the population-based HypnoLaus Sleep Cohort (48.3% men, 57±11 years old) were analysed. The apnoea-hypopnoea index was measured during REM and non-REM sleep (as REM-AHI and NREM-AHI, respectively). Regression models were used to explore the associations between REM-SDB and hypertension, diabetes, metabolic syndrome and depression in the entire cohort and in subgroups with NREM-AHI <10 events·h-1 and total AHI <10 events·h-1The prevalence of REM-AHI ≥20 events·h-1 was 40.8% in the entire cohort. An association between increasing REM-AHI and metabolic syndrome was found in the entire cohort and in both the NREM-AHI and AHI subgroups (p-trend=0.014, <0.0001 and 0.015, respectively). An association was also found between REM-AHI ≥20 events·h-1 and diabetes in both the NREM-AHI <10 events·h-1 (odds ratio (OR) 3.12 (95% CI 1.35-7.20)) and AHI <10 events·h-1 (OR 2.92 (95% CI 1.12-7.63)) subgroups. Systolic and diastolic blood pressure were positively associated with REM-AHI ≥20 events·h-1REM-SDB is highly prevalent in our middle-to-older age sample and is independently associated with metabolic syndrome and diabetes. These findings suggest that an increase in REM-AHI could be clinically relevant.