tbuckley/cabot-search huggingface dataset:
EVALUATING THE ASSOCIATION BETWEEN PSYCHOSOCIAL FACTORS AND FIFA 11+ IMPLEMENTATION INTENTION IN YOUTH SOCCER COACHES
Authors: Oluwatoyosi Owoeye, Muge Bulat, Carly McKay, Tate Hubka, Luz Palacios-Derflingher, Kathryn Schneider, Carolyn Emery
Journal: British Journal of Sports Medicine (2017)

Background The FIFA 11+ program is efficacious in preventing lower extremity injuries in youth soccer players; however, its implementation remains a challenge. Coaches' beliefs and actions regarding injury prevention may influence program implementation. Objective To describe baseline psychosocial factors and evaluate their relationship with intended FIFA 11+ implementation amongst youth soccer coaches, using the Health Action Process Approach (HAPA) behaviour change model. Design Cross-sectional study. Setting Community youth soccer. Participants Seventy-nine youth soccer coaches from across Canada who attended a FIFA 11+ workshop (Spring 2016) during a nationwide program implementation initiative. Assessment of Risk Factors A HAPA-based questionnaire was used to measure risk perceptions (RP), outcome expectancies (OE) and task self-efficacy (TSE) on a 7-point Likert scale. Scale levels were combined (positive, negative and neutral) to describe baseline values. Spearman correlation was used to assess relationship between factors and intention (INT) (with Bonferroni correction). Main Outcome Measurements INT to implement the FIFA 11+ in the successive soccer season as measured by the questionnaire. Results In total, 92.4% of coaches completed the survey. Most coaches (84.6%) believed the overall risk of injury in youth soccer was high (RP). 80.6% of coaches believed soccer injuries were preventable (OE1) and 94.4% believed that the FIFA 11+ would decrease injury risk (OE2). 69.1% were confident in their understanding of the FIFA 11+ (TSE1) and 76.8% were confident in their ability to use it (TSE2). Most coaches (82.5%) intended to use the program (INT). Only TSE2 was found to be significantly associated with INT (r s =0.42, p=0.001). Conclusions This preliminary analysis demonstrates that task self-efficacy relating to youth soccer coaches' confidence in being able to use the FIFA 11+ correlates positively with their intention to implement the program. No other significant relations were found between the other psychosocial factors and coaches' intention.
Small-bowel endoscopy
Authors: G. Gay, M. Delvaux
Journal: Endoscopy (2008)

The endoscopic examination of the small bowel or enteroscopy has reached maturity with the introduction of video capsule endoscopy (VCE) and double balloon enteroscopy (DBE). In adults, VCE has proven effective in the investigation of patients with obscure digestive bleeding (ODB), inflammatory bowel diseases (IBD), and celiac disease 1 2 3. An Australian study published in 2006 4 showed the clinical usefulness of VCE in the diagnosis of small-bowel tumors, the prevalence of which seems to be underestimated in the literature. The use of VCE appears to significantly modify the management of patients with small-bowel tumors. Few studies have so far evaluated VCE in pediatric patients. Therefore, we would like to analyze and comment on an Italian study reporting a large experience of VCE in pediatric patients 5. Again, VCE appears to significantly influence the work-up of the patients. Since its introduction by Yamamoto et al. 6, DBE has been evaluated in several studies, with some investigators suggesting that VCE and DBE complement each other 7. A recent German study 8 reports the results of a large multicenter set of DBE therapeutic procedures, including technical aspects and complications.
PTH-015 Low risk adenomas with villous component resected at bowel scope – outcomes at colonoscopy
Authors: A Elzubeir, AM Verma
Journal: Endoscopy (2017)

<h3>Introduction</h3> Adenomas detected at Bowel Scope are classified based on the BSG guideline on adenoma follow up. Subjects with high or intermediate risk adenomas are referred for colonoscopy to clear the whole colon of polyps. Subjects with low risk adenomas (one or two sub 1 cm adenomas) undergo polypectomy and are discharged. However, in deviation to the guideline, if adenomas have villous component – tubulovillous adenoma (TVA) or villous adenoma (VA), they are upstaged to intermediate risk and subjects are referred for colonoscopy. We audit the outcome of the colonoscopies in subjects who have been upstaged. <h3>Method</h3> Interrogating the Northamptonshire Bowel Scope database, subjects with upstaged adenomas were identified. Colonoscopy and histology reports were reviewed, data collated and analysed. This covered a time period from July 2014 to February 2017 (6000+ Bowel Scope procedures have been performed). <h3>Results</h3> • 64 subjects (~1% of Bowel Scope subjects) had upstaged adenomas. • 47 males (73.4%) and 17 females (26.6%), 60 TVAs and 4 VAs. • 58 subjects had 1 adenoma, six had 2 adenomas. • Two subjects had 2 adenomas with villous component (1 had two TVAs with high grade dysplasia). • 66 TVAs/VAs in total, mean and median size=6 mm. • 24 in rectum (36.4%), 35 in sigmoid colon (53.0%), 7 in descending colon (10.6%). • 6 subjects have not had colonoscopy (9.4%) - 4 (male) subjects declined, 2 subjects awaiting colonoscopy. • 36 (56.3%) had no further adenomas seen at colonoscopy (2 hyperplastic polyps). • 22/64 (34.4%) subjects had further adenomas – 17 males (81.0%), 4 females (19.0%). • 14 single adenomas, 3 multiple, 1 serrated adenoma (SSA) and 4 non-retrieved. • 27 adenomas resected, 23 diminutive (sub 5 mm, 20 TAs, 2 TVAs, 1 SSA). • 4 larger adenomas; 9 mm, 9 mm, 12 mm and 20 mm (all TVAs). • After colonoscopy, 54/58 (93.1%) patients classed as low risk, 1 (1.7%) as intermediate risk and 3 (5.2%) as high risk. <h3>Conclusion</h3> 66 subjects with low risk adenomas at Bowel Scope upstaged due to villous component yielded 58 colonoscopies thus far (90.6% of eligible) with an overall polyp detection rate of 39.7% and adenoma detection rate of 31.0%. There is a male predominance, 56.3% yielded no adenomas. 85.2% of adenomas resected are diminutive. Only 4 (male) subjects remain upstaged after colonoscopy to intermediate or high risk groups (6.1%). This data opens up a debate to whether upstaging subjects found to have low risk adenomas with villous component is an effective strategy. 93.9% of subjects end up classed as low risk after colonoscopy and the vast majority of adenomas resected at colonoscopy are diminutive. The number needed to colonoscope to remain upstaged is 14.5. <h3>Reference</h3> . SR Cairns, JH Scholefield, RJ Steele, et al. Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002). Gut2010;59:666–690. <h3>Disclosure of Interest</h3> None Declared
Genomic profiling of ER <sup>+</sup> breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance
Authors: Jennifer M. Giltnane, Katherine E. Hutchinson, Thomas P. Stricker, Luigi Formisano, Christian D. Young, Monica V. Estrada, Mellissa J. Nixon, Liping Du, Violeta Sanchez, Paula Gonzalez Ericsson, Maria G. Kuba, Melinda E. Sanders, Xinmeng J. Mu, Eliezer M. Van Allen, Nikhil Wagle, Ingrid A. Mayer, Vandana Abramson, Henry Gόmez, Monica Rizzo, Weiyi Toy, Sarat Chandarlapaty, Erica L. Mayer, Jason Christiansen, Danielle Murphy, Kerry Fitzgerald, Kai Wang, Jeffrey S. Ross, Vincent A. Miller, Phillip J. Stephens, Roman Yelensky, Levi Garraway, Yu Shyr, Ingrid Meszoely, Justin M. Balko, Carlos L. Arteaga
Journal: Science Translational Medicine (2017)

Genomic profiling of ER + /HER2 − breast tumors after short-term estrogen deprivation revealed alterations associated with intrinsic resistance and provided mechanistic insights.
Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action
Authors: Kyu-Seon Oh, Heta Patel, Rachel A. Gottschalk, Wai Shing Lee, Songjoon Baek, Iain D.C. Fraser, Gordon L. Hager, Myong-Hee Sung
Journal: Immunity (2017)
BRAF mutation predicts for MEK-dependence in non-small cell lung cancer (NSCLC).
Authors: Ensar Halilovic, Christine Pratilas, Ayana Sawai, Olivera Grbovic, Neal Rosen, David Solit
Journal: Cancer Research (2007)

5247   Constitutive ERK signaling is common in human cancer and is often the result of activating mutations of BRAF, RAS and upstream receptor tyrosine kinases. Missense BRAF kinase domain mutations are frequently observed in melanoma, colon and thyroid cancers and less frequently in lung and other cancer types. The vast majority (>90%) involve a glutamic acid for valine substitution at codon 600 (V600E), which results in elevated BRAF kinase activity. BRAF kinase domain mutations with intermediate and impaired kinase activity have also been identified, most frequently in NSCLC. We have previously reported that tumors with V600E BRAF mutation are selectively sensitive to MEK inhibition. Using the potent and selective MEK1/2 inhibitor PD0325901 (Pfizer), we examined a panel of NSCLC cell lines with mutant EGFR, KRAS, and/or low, intermediate and high-activity BRAF kinase domain mutations for MEK dependence. In all but one case, EGFR, KRAS and BRAF mutations were mutually exclusive with the exception being a cell line with concurrent NRAS and intermediate activity BRAF mutations. Consistent with our prior results, NSCLC cells with V600E BRAF mutation were exquisitely sensitive to MEK inhibition (PD0325901 IC50 of 2nM). The proliferation of cells with non-V600E mutations, including those with high (G469A), intermediate (L597V) and impaired (G466V) kinase activities, was also MEK dependent with IC50’s ranging between 2.7 and 80 nM. Inhibition of MEK in these cells resulted in downregulation of cyclin D1 and G1 growth arrest, with variable induction of apoptosis. Despite high basal ERK activity, NSCLC tumor cells with EGFR mutation were uniformly resistant to MEK inhibition (at doses of up to 500nM), despite effective and prolonged inhibition of ERK phosphorylation. Tumor cells with RAS mutation had a more variable response, with some cell lines demonstrating sensitivity, while others were completely resistant. There was no correlation between basal ERK activity and sensitivity to MEK inhibition. A strong inverse correlation between Akt activity and PD0325901 sensitivity was observed. These results suggest that MEK inhibition may be useful therapeutically in tumors with V600E and non-V600E BRAF kinase domain mutations. The results also suggest that inhibition of both MEK and Akt signaling may be required in NSCLC tumors with high basal AKT activity.
FRI0656 Semiautomatic analysis of erosion volume by HR-PQCT in patients with rheumatoid arthritis
Authors: K Chiba, N Iwamoto, M Osaki, A Kawakami
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> HR-pQCT is a high resolution CT dedicated to human extremities. It has been used mainly for osteoporosis, while in more recent years it has been applied to research in rheumatoid arthritis (RA). <h3>Objectives</h3> The purpose of this study is to develop a method to quantify the volume of erosions in RA patients semiautomatically using second generation HR-pQCT. <h3>Methods</h3> Twenty patients with RA (70±8 years, 15 female, 5 male) participated in this study. The second and third MCP joints were scanned using HR-pQCT (XtremeCT II, Scanco Medical, Switzerland) at the voxel size of 61μm. The erosion volume was measured semiautomatically using the dedicated software (TRI/3D-BON, Ratoc System Engineering, Tokyo). All concave regions on the bone surface around the MCP joints were extracted automatically by subtracting the bone region from the smoothed bone model. Erosions were selected manually by a medical doctor based on certain criteria. The volume of the erosions were measured by voxel counting. <h3>Results</h3> In a total of 37 joints (3 joints were excluded due to severe deformities), 40 erosions were detected by HR-pQCT (phalanx side: 9 erosions, metacarpal side: 31 erosions). The average volume of the erosions was 1.84mm<sup>3</sup>, minimum 0.08mm<sup>3</sup>, and maximum 16.3mm<sup>3</sup>. <h3>Conclusions</h3> The semiautomatic method to quantify the volume of erosions at MCP joints in RA patients by HR-pQCT was developed. The opinion as to whether concave regions are pathological erosion or physiological concave, vascular channel or recess of osteophyte is occasionally difficult and should be performed by an experienced tester. <h3>Disclosure of Interest</h3> None declared
04.10 Chronic inflammation regulates the mrna stabilome in rheumatoid arthritis fibroblast-like synoviocytes
Authors: Konstantinos Loupasakis, David Kuo, Christopher Sohn, Bethany Syracuse, Eugenia G Giannopoulou, Sung Ho Park, Gunnar Rätsch, Lionel B Ivashkiv, George D Kalliolias
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Chronic synovial inflammation is a hallmark of rheumatoid arthritis (RA). During the long-term course of RA synovitis, chronic exposure of FLS to pro-inflammatory cytokines, such as TNF, induces a constellation of genes, which perpetuate synovial inflammation and provoke joint damage. Inflammation-induced gene expression evolves in a temporal order and involves two integrated processes: transcription and mRNA decay. Although the molecular mechanisms regulating transcription are well characterised, little is known about the impact of mRNA stability on gene expression and the genome-wide impact of chronic inflammation on decay rates of mRNA transcripts in RA FLS. <h3>Materials and methods</h3> Chronic synovitis was modelled <i>ex vivo</i> by long-term exposure of RA FLS to TNF. RNA-sequencing was performed, gene-transcripts were quantified, and DESeq2 was used for differential testing between TNF treated and control libraries. For pathway analysis, MSigDB and Panther were used. Differentially stable gene transcripts were identified between time points of TNF stimulation by specific statistical analytical tools. <h3>Results</h3> In our experimental system, long-term exposure of FLS to TNF induces a biphasic gene expression program. Initially, the inducible transcriptome consists primarily of unstable transcripts, but progressively switches and becomes dominated by very stable transcripts. This temporal switch is due to: a) TNF-induced prolonged stabilisation of previously unstable transcripts that enables progressive transcript accumulation over days and b) sustained expression and late induction of very stable transcripts. TNF-induced mRNA stabilisation in RA FLS occurs during the late phase of TNF response, is MAPK-dependent, and involves several genes with pathogenic potential, such as pro-inflammatory cytokines (eg, IL-6), a series of neutrophil-recruiting chemokines (eg, CXCL1, CXCL3, IL-8/CXCL8), CCL2, and PTGS2. <h3>Conclusions</h3> These results provide the first insights into genome-wide regulation of mRNA stability by TNF in RA FLS, and highlight the potential contribution of dynamic regulation of the mRNA stabilome during the chronic course of RA synovitis. Inhibition of inflammation-induced mRNA-stabilising pathways may offer new opportunities for therapeutic intervention in RA synovitis. The results of the current study support a model where continuously active transcription in concert with mRNA stabilisation shape the aggressive behaviour of FLS during the chronic course of RA synovitis.
EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression
Authors: Xueran Chen, Huihui Ma, Zhen Wang, Shangrong Zhang, Haoran Yang, Zhiyou Fang
Journal: Cancer Research (2017)

Gliomas with mutant p53 occurring in 30% of glioma patients exhibit therapeutic resistance and poor outcomes. In this study, we identify a novel mechanism through which mutant p53 drives cancer cell survival and malignant growth. We documented overexpression of the zinc finger protein ZDHHC5 in glioma compared with normal brain tissue and that this event tightly correlated with p53 mutations. Mechanistic investigations revealed that mutant p53 transcriptionally upregulated ZDHHC5 along with the nuclear transcription factor NF-Y. These events contributed to the development of glioma by promoting the self-renewal capacity and tumorigenicity of glioma stem-like cells, by altering the palmitoylation and phosphorylation status of the tumor suppressor EZH2. Taken together, our work highlighted ZDHHC5 as a candidate therapeutic target for management of p53-mutated gliomas. Cancer Res; 77(18); 4998-5010. ©2017 AACR.
How Frank Hawking, DM, and Table Salt, Helped Eliminate Lymphatic Filariasis From China
Authors: Justin D. Arnold, Saurabh Singh
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
TMPRSS2–ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer
Authors: Ken J Kron, Alexander Murison, Stanley Zhou, Vincent Huang, Takafumi N Yamaguchi, Yu-Jia Shiah, Michael Fraser, Theodorus van der Kwast, Paul C Boutros, Robert G Bristow, Mathieu Lupien
Journal: Nature Genetics (2017)
Music Therapy for Children With Autism Spectrum Disorder
Authors: Sarabeth Broder-Fingert, Emily Feinberg, Michael Silverstein
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
植物ウイルスに基づくナノ粒子の血清アルブミン「カモフラージュ」はそれらの抗体認識を妨げ薬物動態を増強する
Authors: Pitek Andrzej S, Jameson Slater A, Veliz Frank A, Shukla Sourabh, Steinmetz Nicole F
Journal: Biomaterials (2016)
Interferon Gamma (IFNγ)/STAT1 Signaling in Host Antigen Present Cells Suppresses MHC Class II-Dependent Presentation of Self-Antigens and Development of Graft Versus Host Disease (GVHD)
Authors: Caisheng Lu, Huihui Ma, Liangsong Song, Shirong Li, Suzanne Lentzsch, Markus Y Mapara
Journal: Blood (2016)
FRI0750-HPR Construct validity of the international physical activity questionnaire – long form in patients with axial spondyloarthritis
Authors: TW Swinnen, S Willemijns, W Dankaerts, R Westhovens, K de Vlam
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Physical activity (PA) is increasingly recognized as an important outcome measure in patients with axial spondyloarthritis (axSpA). Indeed, PA interventions in axSpA have shown to improve clinical status and to reduce comorbidity. The International Physical Activity Questionnaire-Long Form (IPAQ-LF) may be a feasible self-reported PA measurement tool, but its validity is unknown in axSpA. <h3>Objectives</h3> To establish the convergent construct validity of the IPAQ-LF in axSpA. <h3>Methods</h3> Forty patients with axSpA (Male/Female: 24/16; Mean±SD, Age:44.38±11.30 yrs, BMI: 26.27±5.11 kg/m<sup>2</sup>, disease duration: 11.40±9.50 yrs, disease activity (BASDAI): 3.69±2.59) completed the IPAQ-LF and wore the SenseWear Pro3 Multisensor Armband during five consecutive days (three weekdays and two weekend days). A priori, significant directional associations evidenced by Spearman correlation coefficients of ≥.50 were hypothesized between IPAQ-LF total or its subscales and the armband to conform convergent construct validity (p&lt;.05). <h3>Results</h3> IPAQ-LF total PA (Median (IQR): 16.71 (5.91–45.15) MET.hrs/day) was associated with Physical Activity Level (r=.434, p&lt;.01), moderate to (very)vigorous PA (MET≥3, r=.439, p&lt;.01), moderate PA (MET ≥3&lt;6, r=.432, p&lt;.01) and inactive time (MET≤1.8, r=-.382, p&lt;.05) obtained with the armband. Similar, IPAQ-LF moderate PA (Median (IQR): 10.39 (2.41–23.71) MET.hrs/day) was related with PAL (r=.492, p&lt;.01), moderate to (very)vigorous PA (r=.456, p&lt;.01), moderate PA (r=.444, p&lt;.01) and inactive time (r=-.491, p&lt;.05). Also, IPAQ sitting (Median (IQR): 14.91 (10.89–20.80) hrs/day) was correlated to PAL (r=-.461, p&lt;.01), moderate to (very)vigorous PA (r=-.391, p&lt;.05), moderate PA (r=-.386, p&lt;.05) and inactive time (r=.496, p&lt;.01). No relevant nor significant correlations were found for the other IPAQ-LF subscales. Taken together, no hypothesis could be confirmed. <h3>Conclusions</h3> Even at a group level, the convergent construct validity of IPAQ-LF in axSpA was not confirmed. Self-reported PA outcomes may provide important contextual information on PA, but perform poor at quantifying PA levels in axSpA. Future research on a feasible self-reported PA measurement tool for these patients is required. <h3>Disclosure of Interest</h3> None declared
角膜輪部上皮細胞を用いた組織工学的全層角膜代替品の構築とヒト胚性幹細胞から誘導した角膜内皮細胞様細胞【Powered by NICT】
Authors: Zhang Canwei, Du Liqun, Sun Peng, Shen Lin, Zhu Jing, Pang Kunpeng, Wu Xinyi
Journal: Biomaterials (2017)