tbuckley/cabot-search huggingface dataset:
Testosterone Treatment of Depressive Disorders in Men
Authors: Shalender Bhasin, Stuart Seidman
Journal: JAMA Psychiatry (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
GOG 3016/ENGOT-cx9: An open-label, multi-national, randomized, phase III trial of cemiplimab, an anti-PD-1, versus investigator's choice (IC) chemotherapy in ≥ second-line recurrent or metastatic cervical cancer
Authors: K.S. Tewari, I. Vergote, A. Oaknin, E. Alvarez, S. Gaillard, S. Lheureux, D. Rischin, A.D. Santin, M. Feng, M. Mathias, M. Fury, I. Lowy, B.J. Monk
Journal: Annals of Oncology (2018)
the doctor told him
Authors: D.A. Frater
Journal: Annals of Internal Medicine (2018)

Ad Libitum20 November 2018the doctor told himD.A. Frater, MDD.A. Frater, MDDallas, Texas (D.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-0665 Audio Reading - “the doctor told him” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "the doctor told him," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail and maybe shouldn't havethat a memory is as unique as a fingerprintas singular asthe moment that created itan attachment between neuronsstronger in pain and surpriseweaker beneath the weight of timepreserved by repetitionand that this fading of her mindwas due to the falling awayof attachmentsmoments places dissolvingfrom their past each partingof frayed nerves explaining moreher forgetting more perhaps evenhis insistence that she say his nameagain and again and again Author, Article, and Disclosure InformationAffiliations: Dallas, Texas (D.F.)Current Author Address: D.A. Frater, MD; e-mail, [email protected]md. PreviousarticleNextarticle Advertisement Audio Reading - “the doctor told him” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "the doctor told him," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 20 November 2018Volume 169, Issue 10Page: 730KeywordsMemoryNervesNeurons ePublished: 20 November 2018 Issue Published: 20 November 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A facile fabrication of novel stuff with antibacterial property and osteogenic promotion utilizing red phosphorus and near-infrared light
Authors: Bo Huang, Lei Tan, Xiangmei Liu, Jun Li, Shuilin Wu
Journal: Bioactive Materials (2018)

Bone-implant materials are important for bone repairing and orthopedics surgery, which include bone plates and bone nails. These materials need to be designed not only considering its biostability and biocompatibility, but also their by-products induced infection after therapy or long-time treatment in vivo. Thus, the development of novel implant materials is quite urgent. Red phosphorus has great biocompatibility and exhibits efficient photothermal ability. Herein, a red phosphorus/IR780/arginine-glycine-asparticacid-cysteine (RGDC) coating on titanium bone-implant was prepared. The temperature sensitivity of Staphylococcus aureus biofilm is enhanced in the presence of ROS produced by IR780 with 808 nm light irradiation. With keeping the cells and tissues normal, a high antibacterial performance can be realized by near-infrared (808 nm) irradiated within 10 min at 50 °C. Besides the high effective antibacterial efficacy provided by photothermal therapy (PTT) and photodynamic therapy (PDT), the RGDC decorated surface can also possess an excellent performance in osteogenesis in vivo.
Abstract 18945: miR-208a-3p is Downregulated in Cardiac Remodeling and Possibly Controls Gata4 Expression
Authors: Bruna Farjun, Raiana A Barbosa, Leonardo M Alves, Grazielle D Suhett, Leonardo M Pinto, Luis Felipe S Paula, Guilherme V Brasil, Alysson R Carvalho, Jose H Nascimento, Adriana B Carvalho
Journal: Circulation (2013)

miR-208a-3p, a cardiac specific microRNA encoded by an intron of the α-myosin heavy chain (α-MHC) gene, is a predicted post-transcriptional repressor of Gata4. Hence, the aim of this work was to correlate the temporal expression profile of miR-208a-3p and Gata4 in cardiac remodeling after myocardial infarction (MI). Wistar rats were submitted to permanent occlusion (PO) of the left anterior descending artery and analyzes were performed in SHAM and MI groups with 2 (n=10 e n=7), 28 (n=8 e n=9) and 90 days post-PO (n=8 e n=9). Cardiac function was examined by echocardiography and Langendorff, while infarct area was obtained from histological analyzes. The relative expression of miR-208a-3p, α-MHC and Gata4 were obtained by RT-qPCR. There were no differences in infarct areas between infarcted animals in all timepoints and functional data were consistent with dilated cardiomyopathy. The relative expression of miR-208a-3p was downregulated both 2 days post-PO (0.12 ± 1.52 p&lt;0.01) and 90 days post-OP (0.18 ± 1.78, p&lt;0.01) in the MI group when compared to SHAM. mRNA levels of α-MHC and Gata4 were also decreased in the MI group at the same times post-PO (α-MHC 2 days: 0.004 ± 6.98, 90 days: 0.05 ± 3.42; Gata4 2 days: 0.25 ±1.54, 90 days: 0.24 ± 3.01). Pearson’s correlation coefficient revealed the existence of a linear correlation between the mRNA levels of Gata4 and α-MHC at 2 days (p=0.0003, R2=0.78) and 90 days post-PO (p&lt;0.0001, R2=0.86). Moreover, the correlation between Gata4 expression and miR-208a-3p was also present at 2 days (p=0.009, R2=0.54) and 90 days post-PO (p=0.04, R2=0.34), as well between α-MHC e miR-208a-3p at 2 days post-PO (p=0.01, R2=0.49). Since miR-208a-3p is coexpressed with α-MHC, which is a direct target of Gata4, we propose that miR-208a-3p decreases Gata4 expression through negative feedback loop. In this context, miR-208a-3p would function as a rheostat, regulating the levels of Gata4.
Contrast Echocardiographic Perfusion Imaging in Clinical Decision-Making for Cardiac Masses in Patients With a History of Extracardiac Malignant Tumor
Authors: Yu-Hang Mao, You-Bin Deng, Ya-Ni Liu, Xiang Wei, Xiao-Jun Bi, Qiao-Ying Tang, Yi-Bin Wang, Xin-Yu Wang
Journal: JACC. Cardiovascular imaging (2018)
ASTRIS global real world study of osimertinib in patients (pts) with EGFR T790M non-small cell lung cancer (NSCLC): Subpopulation analyses
Authors: M. Provencio, P.K. Cheema, J.F. Vansteenkiste, B.C. Cho, C. Zhou, J. Yu, C. Martin, K. Park, Y. He, Y. Hu, D. Vicente, M. Miranda, J. Rigas, F. de Marinis
Journal: Annals of Oncology (2018)
Review: In adults, increasing ω-6 fatty acid intake does not reduce mortality or overall cardiovascular events
Authors: Donald A. Smith
Journal: Annals of Internal Medicine (2018)

ACP Journal Club20 November 2018Review: In adults, increasing ω-6 fatty acid intake does not reduce mortality or overall cardiovascular eventsDonald A. Smith, MD, MPHDonald A. Smith, MD, MPHIcahn School of Medicine at Mount Sinai, New York City, New York, USA (D.A.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2018-169-10-051 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationHooper L, Al-Khudairy L, Abdelhamid AS, et al. Omega-6 fats for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2018;7:CD011094. https://pubmed.ncbi.nlm.nih.gov/30019765Clinical Impact RatingsGIM/FP/GP: Neurology: Public Health: References1 Sacks FM, Carey VJ, Fruchart JC. Combination lipid therapy in type 2 diabetes [Letter]. N Engl J Med. 2010;363:692-4; author reply 694-5. [PMID: 20842772] Google Scholar2 Bang HO, Dyerberg J, Nielsen AB. Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet. 1971;1:1143-5. [PMID: 4102857] Google Scholar3 Yokoyama M, Origasa H, Matsuzaki M, et al; Japan EPA Lipid Intervention Study (JELIS) Investigators. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007;369:1090-8. [PMID: 17398308] Google Scholar4 ASCEND Study Collaborative Group, Bowman L, Mafham M, et al. Effects of n-3 fatty acid supplements in diabetes mellitus. N Engl J Med. 2018;379:1540-50. [PMID: 30146932] Google Scholar Author, Article, and Disclosure InformationAffiliations: Icahn School of Medicine at Mount Sinai, New York City, New York, USA (D.A.S.)This article was published at Annals.org on 6 November 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReview: Long-chain ω-3 fatty acids have no effect on mortality or overall cardiovascular events Donald A. Smith Review: Long-chain ω-3 fatty acids have no effect on mortality or overall cardiovascular events Donald A. Smith Metrics 20 November 2018Volume 169, Issue 10Page: JC51KeywordsAnginaCongenital heart diseaseDietFatty acidsHigh density lipoprotein cholesterolMortalityMyocardial infarctionOilsPopulation statisticsStatins ePublished: 20 November 2018 Issue Published: 20 November 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Subcutaneous treprostinil for the treatment of severe non-operable chronic thromboembolic pulmonary hypertension (CTREPH): a double-blind, phase 3, randomised controlled trial
Authors: Roela Sadushi-Kolici, Pavel Jansa, Grzegorz Kopec, Adam Torbicki, Nika Skoro-Sajer, Ioana-Alexandra Campean, Michael Halank, Iveta Simkova, Kristof Karlocai, Regina Steringer-Mascherbauer, Miroslav Samarzija, Barbara Salobir, Walter Klepetko, Jaroslav Lindner, Irene M Lang
Journal: The Lancet Respiratory Medicine (2018)
Abstract A30: Gene regulatory mechanisms governing invasive mucinous adenocarcinoma of the lung (IMA)
Authors: Minzhe Guo, Koichi Tomoshige, Iris Fink-Baldauf, Yutaka Maeda
Journal: Clinical Cancer Research (2018)

Abstract Background: Invasive mucinous adenocarcinoma of the lung (IMA) comprises 5-10% of lung adenocarcinoma. IMA is pathologically characterized as lung tumor cells with goblet cell morphology containing abundant intracytoplasmic mucin. Recent advances using next-generation sequencing technology revealed driver oncogenes (e.g., KRAS mutation and NRG1 fusions) and a gene expression signature (e.g., NKX2-1 negative and SPDEF positive) inducing IMA. However, the genetic mechanism governing the pathogenesis of IMA is not fully understood. Here, we report the mechanism of the gene regulatory network regulating mucins and immune checkpoints in IMA. Methods: Using lentiviral vectors expressing the anti-mucous transcription factor NKX2-1 (also known as TTF-1) and the pro-mucous transcription factor SPDEF, we assessed their functions in regulating the expression of mucins and immune checkpoints in multiple lung cancer cell lines. Using ChIP-seq datasets, we further identified genome-wide binding sites of NKX2-1 and SPDEF in A549 lung carcinoma cells that carry a KRAS mutation and produce mucins. We further deleted such binding sites in the genome using CRISPR/Cas9 to assess the function of the sites. Results: NKX2-1 influenced the expression of immune checkpoints, including PD-L1, and mucin-related genes, including MUC5AC and SPDEF. Notably, NKX2-1 bound to the same noncoding region upstream of MUC5AC as SPDEF. The genomic deletion study using CRISPR/Cas9 indicated that both NKX2-1 and SPDEF bound to the enhancer region (but not the silencer region) of MUC5AC, suggesting that NKX2-1 suppresses mucin gene expression by blocking the activity of the enhancer region but not by recruiting a co-repressor complex such as HDAC to the region. Conclusion: Transcription factors NKX2-1 and SPDEF function as yin and yang to affect the pathogenesis of IMA. Citation Format: Minzhe Guo, Koichi Tomoshige, Iris Fink-Baldauf, Yutaka Maeda. Gene regulatory mechanisms governing invasive mucinous adenocarcinoma of the lung (IMA) [abstract]. In: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; Jan 8-11, 2018; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(17_Suppl):Abstract nr A30.
Prognostic impact of pT3a subclassification based on extent of extraprostatic extension after robot-assisted radical prostatectomy
Authors: K. Kanao, M. Sugie, S. Morinaga, H. Muramatsu, K. Kajikawa, I. Kobayashi, G. Nishikawa, M. Watanabe, K. Zennami, K. Nakamura, M. Sumitomo
Journal: Annals of Oncology (2018)
Prevention of infections in patients with antineutrophil cytoplasm antibody-associated vasculitis: potential role of hydroxychloroquine
Authors: Pavel I Novikov, Nikolai M Bulanov, Anastasiia S Zykova, Sergey V Moiseev
Journal: Annals of the Rheumatic Diseases (2018)

In a recent observational study, Kronbichler et al recorded 95 severe/life-threatening infections in 49 of 192 patients (25.5%) with associated vasculitides (AAV) within approximately 2 years following rituximab initiation.1 Respiratory tract infections were the most common infectious complications. In patients with a positive culture, opportunistic pathogens were frequently seen, though Pneumocystis jirovecii was identified in only one case.

Trimethoprim/sulfamethoxazole prophylaxis was administered in 73 of 192 patients (38.0%) and resulted in an impressive reduction in the risk of severe infectious complications by 70%. Approximately half of patients were treated with 480 mg or 960 mg on alternate days. The optimum prophylactic dose of trimethoprim/sulfamethoxazole in patients with non-HIV remains unknown. The current recommendations for the management of AAV encourage prophylaxis against P. jirovecii infection with trimethoprim/sulfamethoxazole 960 mg on alternate days or 480 mg daily in all patients being treated with cyclophosphamide, where not contraindicated.2 There is some evidence suggesting that a lower dose of trimethoprim/sulfamethoxazole may be equally effective and more safe than 480 mg daily. In a randomised controlled …
Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study
Authors: Joe-Elie Salem, Ali Manouchehri, Melissa Moey, Bénédicte Lebrun-Vignes, Lisa Bastarache, Antoine Pariente, Aurélien Gobert, Jean-Philippe Spano, Justin M Balko, Marc P Bonaca, Dan M Roden, Douglas B Johnson, Javid J Moslehi
Journal: The Lancet Oncology (2018)
Abstract 19250: Urinary Homocysteine Thiolactone Predicts Acute Myocardial Infarction in a Randomized Controlled Homocysteine-lowering B-vitamin Trial
Authors: Hieronim Jakubowski, Kamila Borowczyk, Rafal Glowacki, Ottar Nygård
Journal: Circulation (2015)

Introduction: Elevated plasma total homocysteine (tHcy) is associated with increased risk of coronary artery disease (CAD) and stroke. However, tHcy-lowering by B-vitamin therapy has no effect on cardiovascular disease (CVD), suggesting that tHcy is not causally related to CVD. One Hcy metabolite, Hcy-thiolactone (HTL), not accounted for in clinical tHcy assays, has been independently implicated in CVD. HTL is generated in the human body by methionyl-tRNA synthetase during protein biosynthesis and is cleared by the kidney. Hypothesis: Our objective was to test the predictive value of urinary HTL as risk marker of incident acute myocardial infarction (AMI) and to evaluate potential effect modification by B vitamin treatment and status. Methods and Results: We analyzed urinary HTL in samples from 2048 patients (20.5% female, mean age 61.7 years) who underwent coronary angiography for stable angina pectoris and were recruited to the Western Norway B Vitamin Intervention Trial. Linear regression was used to study determinants of baseline urinary HTL/creatinine and no association was observed with established risk factors such as age, gender, hypertension, body mass index, diabetes, apolipoprotein B and A1. Cox regression was used to study its association with subsequent risk of AMI. During median 4.7-years follow-up, 183 patients (8.9%) suffered from AMI. After adjustment for age, gender, diabetes, smoking, extent of CAD at angiography and left ventricular ejection fraction, per tertile increment in HTL/creatinine was significantly associated with AMI (RR 1.23; 95% CI 1.025-1.474; P=0.026). No significant effect-modification by folate/B12 or B6 treatment was observed. The association was entirely confined to patients with low (below median) levels of the inactive B6 metabolite pyridoxic acid (P-interaction 0.020), and identified patients with low risk. The risk association of plasma tHcy was confined to patients with elevated pyridoxic acid (P-interaction 0.001), and identified patients with high risk. Conclusions: Urinary HTL is a risk predictor of AMI in patients with CAD independent from established risk factors and plasma tHcy, but related to vitamin B6 metabolism. These surprising results should encourage further research into HTL and CVD.
Phase II trial of tepotinib vs sorafenib for treatment-naïve advanced hepatocellular carcinoma (HCC) in Asian patients
Authors: B.-Y. Ryoo, Z. Ren, T.-Y. Kim, H. Pan, K.-M. Rau, H.J. Choi, J.-W. Park, J.H. Kim, C.-J. Yen, B.-H. Kim, D. Zhou, J. Straub, C. Zhao, S. Qin
Journal: Annals of Oncology (2018)
Paradoxical exacerbation of latent interstitial pneumonia by secukinumab in a patient with psoriasis vulgaris
Authors: M. Hayashi, A. Igarashi, K. Okamura, T. Suzuki
Journal: British Journal of Dermatology (2018)

Linked Article: Chijiwa et al. Br J Dermatol 2018; 179:1396–1397.
Abstract P295: Association Between Remained Number of Teeth and Cardiovascular Disease Among Korean Adults
Authors: Hong Seok Lee, Yong-Moon Park, Kyungdo Han
Journal: Circulation (2018)

Background: It has been reported that people with teeth loss have an increased risk of cardiovascular disease. However, there is limited evidence for the specific relationship between remained teeth and cardiovascular disease (CVD). Method: Among subjects who participated in Korea National Health and Nutrition Examination Survey conducted in 2008-2013, a total of 12,612 adults with mean age of 60.2±1.2 years old were analyzed. Number of teeth was classified as number less than 20, from 20 to 27 and more than 27. Multiple logistic regression analysis was performed to determine the relationship between cardiovascular disease and remained teeth number after adjusting for potential confounders. Result: The prevalence of cardiovascular disease was 6.5%, 3.3% and 1.4% respectively in groups having number less than 20, 20 to 27 and more than 27 ( P &lt; 0.001). Total number of cardiovascular disease was 666. Diabetes, hypertension, total cholesterol level, waist circumference, metabolic syndrome had large proportion in a group having less than 20 teeth ( P &lt; 0.001). People having less than 20 remained teeth had statistically significant cardiovascular disease after adjusting for age, sex, body mass index, smoking, drinking alcohol, exercise, education, income status, stress, diabetes, and hypertension. A group having less 20 teeth was likely to have statistically significant relationship with cardiovascular disease. (Odds ratio [OR]: 1.41, 95 % confidence interval [CI]: 1.06-1.89) and stroke (OR:1.90, CI:1.03-3.48). Conclusion: Our findings suggest that the number of remained teeth could be a useful additional indicator for assessing cardiovascular disease and stroke
Host–pathogen interactions and prognosis of critically ill immunocompetent patients with pneumococcal pneumonia: the nationwide prospective observational STREPTOGENE study
Authors: Jean-Pierre Bedos, Emmanuelle Varon, Raphael Porcher, Pierre Asfar, Yves Le Tulzo, Bruno Megarbane, Armelle Mathonnet, Anthony Dugard, Anne Veinstein, Kader Ouchenir, Shidasp Siami, Jean Reignier, Arnaud Galbois, Joël Cousson, Sébastien Preau, Olivier Baldesi, Jean-Philippe Rigaud, Bertrand Souweine, Benoit Misset, Frederic Jacobs, Florent Dewavrin, Jean-Paul Mira
Journal: Intensive Care Medicine (2018)
Progress on children’s mental health services is too slow, says commissioner for England
Authors: Jacqui Wise
Journal: BMJ (2018)

Children’s mental health services show signs of improvement but the current rate of progress is still not good enough, the Children’s Commissioner for England has said.1 Her report comes as new figures show that one in eight 5 to 19 year olds had at least one mental disorder in 2017.2

Last year, 338 633 children accessed Child and Adolescent Mental Health Services (CAMHS), equivalent to 2.85% of the total population of children.

Anne Longfield, the Children’s Commissioner, says this is a small fraction of those who need help and there is a vast gap between what is provided and what children need. She has called for better lower level mental health services including an NHS funded counsellor in every school.

Latest figures from NHS Digital show a slight increase over time in the prevalence of mental …
Abstract 18269: Select Cardiac MicroRNA Are Associated With Prevalent Atrial Fibrillation and Change After AF Ablation
Authors: Raghava Velagaleti, Kahraman Tanriverdi, Honghuang Lin, Nada Esa, Menhel Kinno, Divakar Mandapati, Stanley Tam, Okike Okike, Patrick Ellinor, John Keaney, Emelia Benjamin, Jane Freedman, David McManus
Journal: Circulation (2014)

Introduction: Atrial fibrillation (AF) is the most common arrhythmia in the U.S and biomarkers are needed to identify individuals at risk for AF. Cardiac microRNAs (miRNA) are associated with AF an...
Postoperative complications in elderly patients following pancreaticoduodenectomy lead to increased postoperative mortality and costs. A retrospective cohort study
Authors: Fang Yuan, Yasmin Essaji, Emilie P Belley-Cote, Amiram Gafni, Lekhini Latchupatula, Leyo Ruo, Pablo E Serrano
Journal: International Journal of Surgery (2018)
Enough data to draw conclusions about vitamin D and bone health
Authors: Mark J Bolland, Alison Avenell, Andrew Grey
Journal: BMJ (2018)

The experts’ comments in the news article by Torjesen about our systematic review on the effects of vitamin D supplementation are incorrect or mistargeted.12

Clarke’s comments are wrong. He says that the trials in our meta-analysis had too few participants, used an insufficient dose of vitamin D, and had an insufficient duration of treatment to warrant changing health recommendations, …