tbuckley/cabot-search huggingface dataset:
Endoscopic ultrasound fine-needle aspiration by experienced pulmonologists: a cusum analysis
Authors: Paul Leong, Sheetal Deshpande, Louis B. Irving, Philip G. Bardin, Michael W. Farmer, Barton R. Jennings, Daniel P. Steinfort
Journal: European Respiratory Journal (2017)

Endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA) is an established, minimally invasive way to sample intrathoracic abnormalities. The EBUS scope can be passed into the oesophagus to perform endoscopic ultrasound with bronchoscope-guided fine-needle aspiration (EUS-B-FNA). In cases of suspected lung cancer, a combination of the two techniques is now recommended by consensus guidelines. EBUS TBNA is usually performed by pulmonologists; however, the learning curve for EUS-B-FNA, which may be performed during the same procedure, has not been described. A multicentre, observational Australian study, using prospectively collected data from three experienced pulmonologists was conducted. Cumulative sum (cusum) analysis was used to generate visual learning curves. A total of 152 target lesions were sampled in 137 patients, with an overall sensitivity for malignancy of 94.8%. The sensitivity for malignant lesions outside of the 2009 International Association for the Study of Lung Cancer lymph node map (largely intraparenchymal lesions) was 92.9%. All three operators were competent by conventional cusum criteria. There was one case of pneumothorax, and no episodes of mediastinitis or oesophageal perforation were observed. Our data suggest that experienced pulmonologists can safely and accurately perform EUS-B-FNA, with a high diagnostic sensitivity for both lymph node and non-nodal lesions.
SmiNet-2 : description d’un système de surveillance des maladies transmissibles sur internet en Suède
Authors: P Rolfhamre, A Janson, M Arneborn, K Ekdahl
Journal: Eurosurveillance (2006)

Les systemes electroniques de surveillance des maladies transmissibles ameliorent la qualite de la surveillance en simplifiant les declarations, perfectionnant l’exhaustivite et raccourcissant les delais. 
Dans cet article, nous decrivons les principes et les technologies qui sous-tendent SmiNet-2, le nouveau systeme regional et national de surveillance des maladies transmissibles en Suede. Avec ce systeme, la notification peut etre faite par les medecins (au moyen d’un formulaire sur le web) et par les laboratoires (directement par le systeme de donnees de laboratoires) en passant par internet. Par le biais d’un numero d’identification personnel unique, SmiNet-2 fusionne automatiquement les declarations cliniques et de laboratoire avec les enregistrements de cas. Des utilisateurs privilegies, au niveau national et regional, utilisent un serveur central commun qui contient toutes les declarations et les enregistrements de cas. De plus, SmiNet-2 dispose de serveurs separes au niveau des comtes, avec des outils necessaires pour les investigations d’epidemies, la recherche de contacts et la gestion des cas. 
SmiNet-2 a ete lance en septembre 2004. Les comtes recoivent jusqu’a 90% de toutes les declarations electroniquement. Pendant la premiere annee, SmiNet-2 a recu 54 980 notifications cliniques et 32 765 declarations de laboratoires, qui ont genere 58 891 enregistrements de cas. 
Comme la plupart des medecins en Suede ont facilement acces a internet, il est possible de generaliser les notifications par le web. On peut prevoir que d’ici quelques annees, toutes les notifications a SmiNet-2 se feront via internet. Dans ce contexte, SmiNet-2 presente, compare a d’autres systemes, un certain nombre d’avantages majeurs : la rapidite dans le flux de donnees (y compris au niveau national), l’integration des declarations cliniques et de laboratoires, et la capacite de gerer plus de 50 maladies avec des formulaires de declaration sur mesure au sein d’un systeme unique .
In-State and Interstate Associations Between Gun Shows and Firearm Deaths and Injuries
Authors: Ellicott C. Matthay, Jessica Galin, Kara E. Rudolph, Kriszta Farkas, Garen J. Wintemute, Jennifer Ahern
Journal: Annals of Internal Medicine (2017)

Gun shows are an important source of firearms, but no adequately powered studies have examined whether they are associated with increases in firearm injuries.To determine whether gun shows are associated with short-term increases in local firearm injuries and whether this association differs by the state in which the gun show is held.Quasi-experimental.California.Persons in California within driving distance of gun shows.Gun shows in California and Nevada between 2005 and 2013 (n = 915 shows) and rates of firearm-related deaths, emergency department visits, and inpatient hospitalizations in California.Compared with the 2 weeks before, postshow firearm injury rates remained stable in regions near California gun shows but increased from 0.67 injuries (95% CI, 0.55 to 0.80 injuries) to 1.14 injuries (CI, 0.97 to 1.30 injuries) per 100 000 persons in regions near Nevada shows. After adjustment for seasonality and clustering, California shows were not associated with increases in local firearm injuries (rate ratio [RR], 0.99 [CI, 0.97 to 1.02]) but Nevada shows were associated with increased injuries in California (RR, 1.69 [CI, 1.16 to 2.45]). The pre-post difference was significantly higher for Nevada shows than California shows (ratio of RRs, 1.70 [CI, 1.17 to 2.47]). The Nevada association was driven by significant increases in firearm injuries from interpersonal violence (RR, 2.23 [CI, 1.01 to 4.89]) but corresponded to a small increase in absolute numbers. Nonfirearm injuries served as a negative control and were not associated with California or Nevada gun shows. Results were robust to sensitivity analyses.Firearm injuries were examined only in California, and gun show occurrence was not randomized.Gun shows in Nevada, but not California, were associated with local, short-term increases in firearm injuries in California. Differing associations for California versus Nevada gun shows may be due to California's stricter firearm regulations.National Institutes of Health; University of California, Berkeley; and Heising-Simons Foundation.
TCT-119 Short Term TAVR Outcome in Patients with Indication for Oral Anticoagulation
Authors: Felix Woitek, Lisa Crusius, Norman Mangner, Aileen Spindler, Stephan Haussig, Georg Stachel, Florian Schlotter, Philipp Kiefer, Sergey Leontyev, David Michael Holzhey, Friedrich-Wilhelm Mohr, Gerhard Schuler, Axel Linke
Journal: Journal of the American College of Cardiology (2017)
Laser treatment of congenital melanocytic naevi: a systematic review
Authors: C.A.M. Eggen, J.E. Lommerts, E.J. van Zuuren, J. Limpens, S.G.M.A. Pasmans, A. Wolkerstorfer
Journal: British Journal of Dermatology (2017)

Recent studies on congenital melanocytic naevi (CMN) indicate a lower risk of melanoma than has been previously assumed. As a result, the treatment paradigm in CMN has shifted from complete removal to cosmetically acceptable, less invasive treatment options, such as laser treatment. Our objective was to review systematically the efficacy and safety of laser therapy for CMN. We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and PubMed. We rated the quality of evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Twenty-four eligible studies (three nonrandomized controlled studies; 21 case series) with 434 patients were included; the majority were of poor quality). Twenty different laser modalities or combinations were evaluated. Overall, the Q-switched laser was used most frequently, although large or giant CMN were generally treated with an ablative laser. Owing to heterogeneity between studies, comparison between laser modalities was hampered and statistical analysis was precluded. Lasers in CMN showed rather good results (albeit with very low-quality evidence) for clearing of hyperpigmentation in the short term. Outcome measures varied widely, patient satisfaction was rarely measured and high incidences of scarring, repigmentation and complications were reported. No malignant change was seen. While most studies report short-term improvement of CMN after laser therapy, there is no high-quality evidence for the efficacy and safety of laser modalities in CMN in the long term. Future research should focus on well-conducted and well-reported prospective studies on different laser modalities for CMN, with the use of recognized and validated outcome measures.
OA03.08 Activity of Ensartinib after Second Generation Anaplastic Lymphoma Kinase (ALK) Tyrosine Kinase Inhibitors (TKI)
Authors: L. Horn, T.A. Leal, G. Oxnard, H. Wakelee, G.R. Blumenschein, S. Waqar, L. Gandhi, A.A. Chiappori, G. Dukart, K. Harrow, C. Liang, F. Tan, J.P. Gockerman, K. Reckamp
Journal: Journal of Thoracic Oncology (2017)
Unnecessary Thyroid Ultrasonography in the Evaluation of Laboratory Thyroid Abnormalities
Authors: Arjun Gupta, Nivedita Arora, Ugis Gruntmanis
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
KIF5B-MET Gene Rearrangement with Robust Antitumor Activity in Response to Crizotinib in Lung Adenocarcinoma
Authors: Jang Ho Cho, Bo Mi Ku, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
Journal: Journal of Thoracic Oncology (2017)
TCT-825 Outcomes of Patients With and Without Hyperlipidemia Undergoing Revascularization for Left Main Coronary Artery Disease: Analysis from the EXCEL Trial
Authors: Shmuel Chen, Bjorn Redfors, Yangbo Liu, Mathias Vrolix, Carlos Macaya, Ori Ben-Yehuda, A. Pieter Kappetein, Joseph Sabik, Patrick Serruys, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
TCT-824 Prediction of Side Branch Occlusion in Percutaneous Coronary Intervention by Coronary Computed Tomography - CT Bifurcation Score as a Novel Tool for Predicting Risk of Intraprocedural Side Branch Occlusion
Authors: Seung Hwa Lee, Soree Kim, Mingi Lim, Jin-Ho Choi
Journal: Journal of the American College of Cardiology (2017)
TCT-546 Performance of the Dual AntiPlatelet Therapy (DAPT) Score in the ADAPT-DES Study
Authors: Sorin Brener, Ajay Jayant Kirtane, Michael Rinaldi, Bernhard Witzenbichler, Franz-Josef Neumann, Timothy Henry, David Cox, Peter L. Duffy, Ernest Mazzaferri, Bruce Brodie, Roxana Mehran, Thomas McAndrew, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Occupational exposure and asthma control
Authors: Dick Heederik
Journal: European Respiratory Journal (2017)

In this issue of the European Respiratory Journal , Dumas et al . [1] describe associations between occupational disinfectant exposure and asthma control in US nurses. Asthma control was defined by using the Asthma Control Test (ACT) and based on responses to five questions on activity limitations, frequency of symptoms and frequency of use of quick-relief medication in the past 4 weeks (β-agonist inhaler, e.g . albuterol, for symptom control). This instrument is not commonly considered an end-point in studies on occupational exposures and asthma, while asthma control is of particular relevance for asthma patients at work. Thus, the use of asthma control using the ACT is of particular interest [2]. According to the Global Initiative for Asthma Statement, asthma control is the extent to which manifestations of asthma can be observed, or have been reduced or removed by treatment. Asthma control has two dimensions; treatment of symptoms and future risk of adverse outcomes. Variables that can determine future adverse outcomes are lung function, exposure to allergens and non-specific stimuli (smoking, indoor and outdoor air quality), socio-economic and psychological problems, comorbidities and eosinophilia. These variables also determine future outcomes of occupational asthma. The ACT includes a limited set of these, in particular variables associated with treatment of symptoms. Poor control of asthma may be the result of ongoing exposure to disinfectants <http://ow.ly/njzC30fJFMj> Jos Rooijackers contributed with some critical comments to earlier versions of this manuscript.
I know what the imaging guidelines say, but...
Authors: Kieran O’Sullivan, Gilat Linn Grunau, Bruce B Forster, Peter P O’Sullivan, Timothy Flynn, Ben Darlow
Journal: British Journal of Sports Medicine (2017)

Despite evidence to the contrary, the public, and clinicians, often believe that low back pain (LBP) diagnosis and management are enhanced through the use of imaging such as MRI and CT. In the USA alone, nearly $6 billion is spent on spinal MRI scans annually, stretching limited resources. We have previously discussed1 how imaging rates for LBP may be safely reduced and aligned with guidelines,2 using methods such as clinician decision support to ‘shape the path’.3 Nevertheless, reducing imaging rates for LBP is difficult. There may be additional value in gaining a better understanding of the decision-making processes, and motivations, of referring clinicians.

There is considerable variation in imaging referral patterns between clinicians, with variation the greatest for LBP presentations not involving trauma or radiculopathy (the majority of people with LBP). This suggests clinician factors, in addition to system factors, contribute to the variation. Many clinicians are aware of, and broadly agree with, recommended clinical …
Progressive Acute Abdominal Pain
Authors: Daniel J. Gross, Lisa Shimotake, Leon Boudourakis
Journal: JAMA Surgery (2017)

A woman in her 50s with a history of systemic lupus erythematosus, congestive heart failure, and diabetes presents to the emergency department with worsening abdominal pain and a 4-day history of progressively worsening abdominal pain and diarrhea. What is your diagnosis?
Feasibility study of FOLFIRINOX as first-line chemotherapy for metastatic pancreatic cancer (KOBE FOLFIRINOX study)
Authors: Yukimasa Hatachi, Hironaga Satake, Takeshi Kotake, Takatsugu Ogata, Yoshihiro Okita, Hisateru Yasui, Akihito Tsuji
Journal: Annals of Oncology (2017)
Effect of secukinumab on quality of life and psoriasis-related symptoms: A comparative analysis versus ustekinumab from the CLEAR 52-week study
Authors: Lluís Puig, Matthias Augustin, Andrew Blauvelt, Alice B. Gottlieb, Ron Vender, Neil J. Korman, Diamant Thaçi, Yang Zhao, Isabelle Gilloteau, Bintu Sherif, Nicole Williams, Adriana Guana, Mark G. Lebwohl
Journal: Journal of the American Academy of Dermatology (2017)
Mesoporous Silica Nanoparticles: Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles (Adv. Healthcare Mater. 20/2017)
Authors: Jian Yang, Jing Tu, Gerda E. M. Lamers, René C. L. Olsthoorn, Alexander Kros
Journal: Advanced Healthcare Materials (2017)

In article number 1700759, Alexander Kros and co-workers describe how mesoporous silica nanoparticles (MSNs) are delivered into cells via membrane fusion thereby omitting endocytosis pathways. Fusion is induced by a pair of complementary coiled-coil lipopeptides inserted into the membrane of cells and in the bilayer of lipid-coated MSNs. In this manner proteins can be efficiently delivered into the cytoplasm of cells.
Primary Pericardial Angiosarcoma Shown on FDG PET/CT
Authors: Ximin Shi, Fang Li
Journal: Clinical Nuclear Medicine (2017)

A 63-year-old woman had persistent bloody pericardial effusion. Tuberculous pericarditis was initially suspected, but empirical antituberculosis therapy was futile. FDG PET/CT study revealed abnormal FDG activity in multiple parts of the pericardium, especially along with aorta and main pulmonary artery, and in the left atrium. However, there was no abnormal activity in other parts of the body. Histopathologic examination revealed primary pericardial angiosarcoma.
Nivolumab-Induced Acute Diabetes Mellitus and Hypophysitis in a Patient with Advanced Pulmonary Pleomorphic Carcinoma with a Prolonged Tumor Response
Authors: Lucien Marchand, Valérie Paulus, Nicole Fabien, Maurice Pérol, Charles Thivolet, Julien Vouillarmet, Pierre Saintigny
Journal: Journal of Thoracic Oncology (2017)
Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017
Authors: David Terkelsen, Jacob Tolstrup, Camilla Hundahl Johnsen, Ole Lund, Helle Kiellberg Larsen, Peder Worning, Magnus Unemo, Henrik Westh
Journal: Eurosurveillance (2017)

We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.
Um Surto de Criptosporidose na Holanda
Authors: I. A. van Asperen, T Mank, G. J. Medema, C Stijnen, A S de Boer, J. F. Groot, P TenHam, J. F. Sluiters, M W Borgdorff
Journal: Eurosurveillance (1996)

Um microbiologista em Spijkenisse, no sudoeste da Holanda ­ que tinha assitido recentemente a um curso de parasitologia ­ identificou em 20 de de Agosto de 1995, oocistos de criptosporidio em fezes de um doente com diarreia. O reexame de 89 amostras de fezes recebidas desde 10 de Agosto e em que nao tinha sido identificado nenhum agente patogenico bacteriano, revelou 15 casos de criptosporidose, que foram confirmados no laboratorio de parasitologia da Universidade de Leiden (Dr. A.M. Polderman). A maioria dos casos eram criancas com menos de 5 anos e mulheres com idade entre 25­35 anos, nenhum tinha evidencia de diminuicao da imunidade.
Response rate and durability of chemotherapy for metastatic Merkel cell carcinoma among 62 patients.
Authors: Jayasri G Iyer, Astrid Blom, Ryan Doumani, Christopher Lewis, Austin Anderson, Christine Ma, Upendra Parvathaneni, Shailender Bhatia, Paul Nghiem
Journal: Journal of Clinical Oncology (2014)

9091 Background: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high propensity to metastasize (> 30%). Distant metastatic MCC is often treated using chemotherapy but its efficacy is unclear because the existing literature: 1) intermingles adjuvant and therapeutic chemotherapy cases and, 2) often includes combined chemo-radiation. Methods: To assess the efficacy of chemotherapy on MCC we performed a retrospective analysis of 62 patients in our cohort with distant MCC metastases evaluable for response to chemotherapy alone.Tumor responses were characterized as complete remission (CR), partial remission (PR), stable disease (SD) or progressive disease (PD) per RECIST. Overall survival (OS), durability of response and progression-free survival (PFS) were also analyzed. Results: Median age of this cohort was 68 years (range: 47 – 96). Median OS from the start of chemotherapy was 9.5 months. Platinum plus etoposide was the most common first line regimen administered to 69% of the patients. Objective response rate (ORR) with front-line chemotherapy was 54% (34/62) with CR in 15% (9/62) of the patients. 7 of 9 patients with CR eventually progressed. The median progression free survival (PFS) for all patients from start of chemotherapy was 93.5 days with 90% of patients progressing by 290 days. Among responders (CR + PR), median PFS was 161 days, median durability of response was 103 days (range: 12 – 522) and 90% progressed in this subgroup by 428 days. Among 30 patients who received a second line chemotherapy regimen, the ORR was 23% (7/30 with 1 CR, 6 PR). Median PFS from start of second line chemotherapy (n=30) was 61 days (range: 11 – 364). Topotecan was the most commonly used second-line regimen (23%). Conclusions: The results of our study suggest that responses to cytotoxic chemotherapy for MCC are frequent but of limited durability. While subject to selection bias in a retrospective study, these data may be useful as a basis for comparison as the “control arm” for trials of new therapeutic modalities in this rare malignancy lacking data from prospective trials.
TCT-167 One-Year Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Lower Extremity Peripheral Artery Intervention
Authors: Houman Khalili, Haekyung Jeon-Slaughter, Ehrin Armstrong, Nicolas W. Shammas, Khusrow Niazi, Scott Kinlay, Mazen Abu-Fadel, Anand Prasad, Bala Ramanan, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2017)
Action Concertée Européenne sur la Borréliose de Lyme (EUCALB)
Authors: S O’Connell
Journal: Eurosurveillance (1996)

L'incertitude sur la dimension du probleme pose par la borreliose de Lyme, le risque de sequelles graves et les insuffisances des techniques de laboratoire pour la detection, ont conduit des chercheurs de 12 pays de l'Union Europeenne (UE) et de deux pays d'Europe de l'est a collaborer. L'Action Concertee Europeenne sur la Borreliose de Lyme (EUCALB), financee par l'UE dans le cadre du programme Biomed 1 et dirigee par le docteur Jeremy Gray de l'Universite de Dublin, coordonne les recherches sur l'ecologie, la biologie moleculaire, la taxonomie et la distribution geographique a travers l'Europe du Borrelia burgdorferi ; l'etude des caracteristiques cliniques et epidemiologiques de la borreliose de Lyme en Europe et les facteurs de risques pour les infections humaines ; et les mesures de prevention comprenant les programmes d'education cibles sur les regions d'endemie.
Retrospective analysis on the needs of early palliative care for outpatients under cancer chemotherapy
Authors: Hidenori Takahashi, Yuji Satomi, Takeshi Suzuki, Aritomo Nanba, Takeo Ishii, Natsumi Iguchi, Tetsuo Hirata, Masato Masuda, Akira Arasaki
Journal: Annals of Oncology (2017)
Rapport sur la première souche de LPV-SARM communautaire en Lettonie
Authors: E Miklaševics, S Hæggman, A Balode, B Sanchez, A Martinsons, B Olsson-Liljequist, U Dumpis
Journal: Eurosurveillance (2004)

Des infections par Staphylococcus aureus resistant a la methicilline acquises dans la communaute (co-SARM) ont ete rapportees partout dans le monde. L'article suivant presente les caracteristiques du premier co-SARM isole en Lettonie. Une souche de LPV-SARM IV ST30 a ete isolee dans un prelevement nasal et le catheter veineux central d'un patient presentant de la fievre et des deficiences polyviscerales. Le profil de l'electrophorese en champ pulse de cette souche etait indiscernable du profil de souches SARM SE00-3 isolees en Suede en 2002-2003 chez 29 patients. Cette souche est liee a la zone du Pacifique Sud et son emergence en Suede et en Lettonie demontre sa dissemination a l'echelle mondiale.
Cardiac Steatosis Detected in Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy and Aortic Stenosis
Authors: J J Suttie, S Dass, S Bull, C Holloway, R Banerjee, P Cox, A Pitcher, B R Franco, J Francis, J Schneider, M Robson, H Watkins, S Myerson, S Neubauer
Journal: Circulation (2011)