Abstract 2763: Health-related quality of life among long-term prostate cancer survivors by primary treatment: A systematic review
Authors: Salome Adam, Anita Feller, Sabine Rohrmann, Volker Arndt
Journal: Cancer Research (2017)

Abstract Introduction: Due to improving prognosis for prostate cancer survivors and increased awareness of late- or long-term treatment effects, monitoring long-term well-being among prostate cancer survivors has gained increasing attention. In this systematic review, we identified and synthesized studies comparing health-related quality of life (HRQoL) among long-term prostate cancer (PC) survivors (i.e. ≥5 years past diagnosis) by primary treatment. Methods: In order to summarize current literature research results, we searched multiple databases, including Pubmed, Medline, Embase, PsychInfo, Cinahl, Web of Science and Cochrane Central Register of Controlled Trials to identify all relevant articles. Studies had to assess at least overall/ general HRQoL plus one HRQoL domain or a minimum of two HRQoL domains. Two independent reviewers systematically extracted the content of the included studies. Results: A total of twelve studies were identified (2 from US, 3 from Japan, 6 from Europe, 1 from US/UK); the majority were observational prospective cohort studies (n=7), and two were RCTs. HRQoL was assessed using the SF-36 (n=7) or EORTC QLQ-C30 (n=5). Instruments to assess symptoms included various questionnaires (e.g., EPIC, IPSS, UCLA and EORTC PR 25). The sample size (all arms combined) was below 100 in 6 studies, between 100 and 200 in 5 studies, and 780 in one study. Comparison groups differed across studies. Although, long-term prostate cancer survivors reported comparable HRQoL to the general population, survivors treated using external beam radiation therapy (EBRT) reported poorer role, social and role physical functioning and a higher burden of diarrhea, pain, sleep disturbance and nausea/vomiting. Results for comparisons of different therapies were not consistent. Whereas studies using the EORTC QLQ-c30 questionnaire did not reveal any statistically or clinically significant results, studies using the SF-36 showed that survivors treated with a radical prostatectomy reported better physical and role functioning as well as higher vitality than survivors treated with AS/WW, ADT and EBRT. However, the latter results were only based on one study. No clear associations were seen between EBRT and OM. Conclusion: This review suggests that HRQol among long-term prostate cancer survivors varies according to primary treatment. However, it remains unclear which treatment options are superior with respect to HRQoL since studies yielded conflicting results, used different comparison groups, or did not have enough power to draw any firm conclusions. Citation Format: Salome Adam, Anita Feller, Sabine Rohrmann, Volker Arndt. Health-related quality of life among long-term prostate cancer survivors by primary treatment: A systematic review [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2763. doi:10.1158/1538-7445.AM2017-2763