tbuckley/cabot-search huggingface dataset:
TLL1 variants do not predict the development of de-novo hepatocellular carcinoma in HCV cirrhotics treated with IFN-free DAA-based regimens
Authors: E. Galmozzi, F. Facchetti, R. D’ambrosio, E. Degasperi, A. Aghemo, R. Soffredini, M. Borghi, R. Perbellini, M. Iavarone, A. Sangiovanni, P. Lampertico
Journal: Journal of Hepatology (2018)
Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E–Deficient Mice
Authors: Tomoya Hara, Pham Tran Phuong, Daiju Fukuda, Koji Yamaguchi, Chie Murata, Sachiko Nishimoto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Issei Imoto, Michio Shimabukuro, Masataka Sata
Journal: Circulation (2018)

The coagulation system is closely linked with vascular inflammation, although the underlying mechanisms are still obscure. Recent studies show that protease-activated receptor (PAR)-2, a major receptor of activated factor X, is expressed in both vascular cells and leukocytes, suggesting that PAR-2 may contribute to the pathogenesis of inflammatory diseases. Here we investigated the role of PAR-2 in vascular inflammation and atherogenesis.We generated apolipoprotein E-deficient ( ApoE-/-) mice lacking systemic PAR-2 expression ( PAR-2-/- ApoE-/-). ApoE-/- mice, which lack or express PAR-2 only in bone marrow (BM) cells, were also generated by BM transplantation. Atherosclerotic lesions were investigated after 20 weeks on a Western-type diet by histological analyses, quantitative reverse transcription polymerase chain reaction, and Western blotting. In vitro experiments using BM-derived macrophages were performed to confirm the proinflammatory roles of PAR-2. The association between plasma activated factor X level and the severity of coronary atherosclerosis was also examined in humans who underwent coronary intervention.PAR-2-/- ApoE-/- mice showed reduced atherosclerotic lesions in the aortic arch ( P<0.05) along with features of stabilized atherosclerotic plaques, such as less lipid deposition ( P<0.05), collagen loss ( P<0.01), macrophage accumulation ( P<0.05), and inflammatory molecule expression ( P<0.05) compared with ApoE-/- mice. Systemic PAR2 deletion in ApoE-/-mice significantly decreased the expression of inflammatory molecules in the aorta. The results of BM transplantation experiments demonstrated that PAR-2 in hematopoietic cells contributed to atherogenesis in ApoE-/- mice. PAR-2 deletion did not alter metabolic parameters. In vitro experiments demonstrated that activated factor X or a specific peptide agonist of PAR-2 significantly increased the expression of inflammatory molecules and lipid uptake in BM-derived macrophages from wild-type mice compared with those from PAR-2-deficient mice. Activation of nuclear factor-κB signaling was involved in PAR-2-associated vascular inflammation and macrophage activation. In humans who underwent coronary intervention, plasma activated factor X level independently correlated with the severity of coronary atherosclerosis as determined by Gensini score ( P<0.05) and plaque volume ( P<0.01).PAR-2 signaling activates macrophages and promotes vascular inflammation, increasing atherosclerosis in ApoE-/- mice. This signaling pathway may also participate in atherogenesis in humans.
Sofosbuvir-based treatment of viral hepatitis C genotype 3 infection – A Polish real-world study
Authors: D. Zarebska-Michaluk, R. Flisiak, J. Jaroszewicz, E. Janczewska, A. Czauz-Andrzejuk, H. Berak, H. Andrzej, A. Staniaszek, A. Gietka, M. Tudrujek, K. Tomasiewicz, D. Dybowska, W. Halota, A. Piekarska, M. Sitko, A. Garlicki, I. Ortowska, S. Krzysztof, T. Belica-Wdowik, B. Baka-Cwierz, M. Wtodzimierz, J. Bialkowska-Warzecha, Ł. Socha, M. Wawrzynowicz-Syczewska, Ł. Laurans, D. Zbigniew, B. Lorenc, B. Dobracka, T. Olga, M. Pawtowska
Journal: Journal of Hepatology (2018)
Clinical Outcomes in biopsy-proven NAFLD patients from the HEPAmet Spanish Registry
Authors: J. Ampuero, R. Aller, R. Gallego-Durán, J. Banales, J. Crespo, N. Mora-Cuadrado, C. Garcia-Monzon, M.J. Pareja, E. Vilar-Gomez, R. Jiménez-Agüero, J. Caballería, M.T.A. Loste, D. Escudero-García, J. Gómez-Camarero, J.L.C. Panero, D.A. De Luis Román, Á. Gónzalez-Rodriguez, M. Latorre, A. Albillos, V. Aguilar-Urbano, J. Salmerón, J.L. Olcoz-Goñi, P. Aspichueta, Á. Santos-Laso, O.L. Iacono, P. Iruzubieta, I. Graupera, M. García-Torres, E. Badia-Aranda, J.A. Guerra, R. Francés, H. Pastor, E.D. Pozo-Maroto, M. Diago, R. Martin-Mateos, S. Benlloch, C. Fernández-Rodríguez, F.J.G.-S. Rey, P. Estevez, R.J. Andrade, J. Turnés, M.R. Gomez
Journal: Journal of Hepatology (2018)
Making a difference: the AMSSM Foundation and humanitarian service
Authors: Margot Putukian
Journal: British Journal of Sports Medicine (2018)

The Foundation of the American Medical Society for Sports Medicine (AMSSM) was started in 1997, just 6 years after the organisation itself was launched. The initial mission of the AMSSM Foundation was to support education and foster research in sports medicine, recognise excellence and achievements of sports medicine physicians and cultivate member and patient relations. In 2011, with the prompting and encouragement of Dr Brian Halpern, a Past President and Founder of AMSSM and Immediate Past President of the AMSSM Foundation, the Foundation Board of Directors expanded the mission statement to include a focus on humanitarian outreach.

A number of AMSSM members travel to provide international medical humanitarian work. The increasing interest of our members encouraged the Foundation to establish a volunteer service project preceding our Annual Meeting. All of the Service Projects emphasise creating supportive environments where youth can exercise and learn about the benefits of a healthy lifestyle.

The first Service Project was held in 2014 in collaboration with Gentilly Charter School in New Orleans, one of 32 schools located in the Louisiana Recovery School District. Approximately 50 AMSSM members, as well as their friends and family, restored portions of the school that was rased by Hurricane Katrina. AMSSM members, …
Candida periprosthetic joint infection: A rare and difficult-to-treat infection
Authors: Laura Escolà-Vergé, Dolors Rodríguez-Pardo, Jaime Lora-Tamayo, Laura Morata, Oscar Murillo, Helem Vilchez, Luisa Sorli, Laura Guío Carrión, José Mª Barbero, Julián Palomino-Nicás, Alberto Bahamonde, Alfredo Jover-Sáenz, Natividad Benito, Rosa Escudero, Marta Fernandez Sampedro, Rafael Pérez Vidal, Lucía Gómez, Pablo S. Corona, Benito Almirante, Javier Ariza, Carles Pigrau
Journal: Journal of Infection (2018)
Histological severity is related to cardiovascular events in lean but not in overweight and obese subjects with NAFLD
Authors: A. Feldman, S. Eder, S. Ruhaltinger, M. Strasser, G. Strebinger, U. Huber-Schönauer, D. Niederseer, L. Stechemesser, B. Paulweber, C. Datz, E. Aigner
Journal: Journal of Hepatology (2018)
Gestational Diabetes Mellitus and Diet: A Systematic Review and Meta-analysis of Randomized Controlled Trials Examining the Impact of Modified Dietary Interventions on Maternal Glucose Control and Neonatal Birth Weight
Authors: Jennifer M. Yamamoto, Joanne E. Kellett, Montserrat Balsells, Apolonia García-Patterson, Eran Hadar, Ivan Solà, Ignasi Gich, Eline M. van der Beek, Eurídice Castañeda-Gutiérrez, Seppo Heinonen, Moshe Hod, Kirsi Laitinen, Sjurdur F. Olsen, Lucilla Poston, Ricardo Rueda, Petra Rust, Lilou van Lieshout, Bettina Schelkle, Helen R. Murphy, Rosa Corcoy
Journal: Diabetes Care (2018)

OBJECTIVE Medical nutrition therapy is a mainstay of gestational diabetes mellitus (GDM) treatment. However, data are limited regarding the optimal diet for achieving euglycemia and improved perinatal outcomes. This study aims to investigate whether modified dietary interventions are associated with improved glycemia and/or improved birth weight outcomes in women with GDM when compared with control dietary interventions. RESEARCH DESIGN AND METHODS Data from published randomized controlled trials that reported on dietary components, maternal glycemia, and birth weight were gathered from 12 databases. Data were extracted in duplicate using prespecified forms. RESULTS From 2,269 records screened, 18 randomized controlled trials involving 1,151 women were included. Pooled analysis demonstrated that for modified dietary interventions when compared with control subjects, there was a larger decrease in fasting and postprandial glucose (−4.07 mg/dL [95% CI −7.58, −0.57]; P = 0.02 and −7.78 mg/dL [95% CI −12.27, −3.29]; P = 0.0007, respectively) and a lower need for medication treatment (relative risk 0.65 [95% CI 0.47, 0.88]; P = 0.006). For neonatal outcomes, analysis of 16 randomized controlled trials including 841 participants showed that modified dietary interventions were associated with lower infant birth weight (−170.62 g [95% CI −333.64, −7.60]; P = 0.04) and less macrosomia (relative risk 0.49 [95% CI 0.27, 0.88]; P = 0.02). The quality of evidence for these outcomes was low to very low. Baseline differences between groups in postprandial glucose may have influenced glucose-related outcomes. As well, relatively small numbers of study participants limit between-diet comparison. CONCLUSIONS Modified dietary interventions favorably influenced outcomes related to maternal glycemia and birth weight. This indicates that there is room for improvement in usual dietary advice for women with GDM.
Disseminated Cutaneous Lesions in a Patient With a Medical History of Myelodysplastic Syndrome
Authors: Seongseok Yun, Lubomir Sokol, Ling Zhang
Journal: JAMA Oncology (2018)

A man in his 50s with a medical history of myelodysplastic syndrome refractory anemia with excess blasts presented with a 2-month history of nonpruritic infiltrative skin lesions on the left upper chest. What is your diagnosis?
Cardiovascular risk factors and fibrosisseverity in NAFLD: is there a link?
Authors: D. Roccarina, M. Guerrero, L.I. Prat, E. Buzzetti, A. Goyale, F. Arico, F. Arico’, M. Rosselli, M. Pinzani, E. Tsochatzis
Journal: Journal of Hepatology (2018)
Abstract 16893: Subclinical Decrease in Myocardial Function in Asymptomatic Infants of Diabetic Mothers: A Tissue Doppler Study
Authors: Jenny E Zablah, Dorota Gruber, Denise A Hayes
Journal: Circulation (2015)

Introduction: Infants of diabetic mothers (IDMs) with cardiac hypertrophy are recognized to have impaired myocardial performance, but less is known about ventricular function in those without hypertrophy. We hypothesized that, in asymptomatic newborns with normal echocardiograms, tissue Doppler imaging (TDI) indices of cardiac function would be decreased in IDMs compared to controls. Methods: This retrospective case-control study involved IDMs ≥ 36 weeks gestational age, at 0 to 7 days of life. Subjects with cardiorespiratory symptoms, ventricular hypertrophy or dysfunction, or any echocardiographic abnormality (other than a patent ductus arteriosus before 4 days of life, or a patent foramen ovale) were excluded. Each subject was matched with 3 controls (healthy infants of non-diabetic mothers) by age (0-24, 25-48, 49-72, or &gt; 72 hours of life), birth weight (± 0.5 kg), body surface area (± 0.03 m 2 ), and by the ultrasound system utilized. TDI systolic (S’), early diastolic (E’), and late diastolic (A’) velocities were measured at the mitral valve (MV) annulus, basal ventricular septum, and tricuspid valve (TV) annulus, and were averaged from 3 consecutive cardiac cycles. Early Doppler inflow velocity to E’ ratios (E/E’) were calculated. Results: Seventy cases (39 male) were identified: first 24 hours (h) of life (n=18), 25-48 h (n=22), 49-72 h (n=14), and &gt; 72 h (n=16). Maternal diabetes was gestational in 60 cases, and pre-existing in 10. Median gestational age was 38 6/7 weeks (range 36-41 2/7), median birth weight 3.65 kg (2.56-5.38), and median BSA 0.22 m 2 (0.17-0.27). Ultrasound system vendors included Siemens ® (n=46), Philips ® (n=23), and General Electric ® (n=1). Cases were matched with 210 controls. IDMs had significantly lower S’ ( p ≤ 0.05) and E’ ( p ≤ 0.01) velocities, and significantly higher E/E’ ratios ( p ≤ 0.01) at the MV, basal septum, and TV compared to controls (Wilcoxon rank-sum test). There were no significant differences in A’ values between groups. Intraclass correlation demonstrated 84-99% interobserver and 98-99% intraobserver reliability. Conclusions: In asymptomatic newborn IDMs without cardiac hypertrophy, TDI suggests a subclinical decrease in systolic and diastolic myocardial function compared to controls.
Carvedilol for Treatment of Red Vulva Syndrome
Authors: Carla Hajj, Nakhle Ayoub
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Osteopenia and Multiple Fractures in an Infant With Harlequin Ichthyosis
Authors: Jan Cezary Sitek, Else Merckoll, Per Arne Tølløfsrud
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Female Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease
Authors: MeiLan K. Han, Emilio Arteaga-Solis, John Blenis, Ghada Bourjeily, Deborah J. Clegg, Dawn DeMeo, Jeanne Duffy, Ben Gaston, Nicola M. Heller, Anna Hemnes, Elizabeth Petri Henske, Raksha Jain, Tim Lahm, Lisa H. Lancaster, Joyce Lee, Marianne J. Legato, Sherry McKee, Reena Mehra, Alison Morris, Y. S. Prakash, Martin R. Stampfli, Rashmi Gopal-Srivastava, Aaron D. Laposky, Antonello Punturieri, Lora Reineck, Xenia Tigno, Janine Clayton
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Female sex/gender is an undercharacterized variable in studies related to lung development and disease. Notwithstanding, many aspects of lung and sleep biology and pathobiology are impacted by female sex and female reproductive transitions. These may manifest as differential gene expression or peculiar organ development. Some conditions are more prevalent in women, such as asthma and insomnia, or, in the case of lymphangioleiomyomatosis, are seen almost exclusively in women. In other diseases, presentation differs, such as the higher frequency of exacerbations experienced by women with chronic obstructive pulmonary disease or greater cardiac morbidity among women with sleep-disordered breathing. Recent advances in -omics and behavioral science provide an opportunity to specifically address sex-based differences and explore research needs and opportunities that will elucidate biochemical pathways, thus enabling more targeted/personalized therapies. To explore the status of and opportunities for research in this area, the NHLBI, in partnership with the NIH Office of Research on Women's Health and the Office of Rare Diseases Research, convened a workshop of investigators in Bethesda, Maryland on September 18 and 19, 2017. At the workshop, the participants reviewed the current understanding of the biological, behavioral, and clinical implications of female sex and gender on lung and sleep health and disease, and formulated recommendations that address research gaps, with a view to achieving better health outcomes through more precise management of female patients with nonneoplastic lung disease. This report summarizes those discussions.
Low density neutrophils, as immunosuppressant, increased in HCC patients, highly correlated with advanced stage, predicted stage I HCC recurrence and all patients’ survival
Authors: C.-H. Huang, C.-Y. Lin, T.-H. Wu, R.W.-J. Jeng, S.-K. Shih, Y.-C. Hsieh, W. Teng, Y.-C. Chen, C.-C. Lin, S.-M. Lin, I.-S. Sheen, Y.-C. Lin
Journal: Journal of Hepatology (2018)
Internalization of canalicular transporters in estradiol 17ß-D-glucuronide-induced cholestasis involves shift from “raft” to “non-raft” membrane domains and clathrin-mediated endocytosis
Authors: G.S. Miszczuk, I. Barosso, R. Andermatten, M.C. Larocca, J. Marrone, R.A. Marinelli, A.C. Boaglio, E.S. Pozzi, M.G. Roma, F.A. Crocenzi
Journal: Journal of Hepatology (2018)
Validation of the ANCA-associated vasculitis patient-reported outcomes (AAV-PRO) questionnaire
Authors: Joanna C Robson, Jill Dawson, Helen Doll, Peter F Cronholm, Nataliya Milman, Katherine Kellom, Susan Ashdown, Ebony Easley, Don Gebhart, Georgia Lanier, John Mills, Jacqueline Peck, Raashid Ahmed Luqmani, Judy Shea, Gunnar Tomasson, Peter A Merkel
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Objectives</h3> To finalise and validate a disease-specific patient-reported outcome (PRO) measure: the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire. Using a 35-item candidate questionnaire developed following 50 qualitative interviews in the UK, USA and Canada, a longitudinal survey was conducted to determine the final scale structure and validate the AAV-PRO. <h3>Methods</h3> Participants were recruited via Vasculitis UK and the Vasculitis Patient-Powered Research Network. The 35-item candidate questionnaire was completed at baseline and 3 months; UK participants completed the EuroQol-5D-5L (EQ-5D-5L), while US participants completed a test–retest exercise, 3–5 days after baseline. Scale structure was defined using exploratory factor analysis (EFA) and Rasch analysis. Convergent and known groups validity, test–retest reliability and longitudinal construct validity were assessed. <h3>Results</h3> There were 626 participants with AAV; &gt;25% reporting ‘active disease’. EFA and Rasch analysis supported a 29-item profile measure comprising six domains: ‘organ-specific symptoms’, ‘systemic symptoms’, ‘treatment side effects’, ‘social and emotional impact’, ‘concerns about the future’ and ‘physical function’. Mean domain scores were higher for participants with ‘active disease’ versus ‘remission’ (p&lt;0.001). Construct validity was demonstrated by correlations between domain scores and the EQ-5D-5L (range r=−0.55 to 0.78), all p&lt;0.0001. In participants reporting ‘no change’ (n=97) during the test–retest, intraclass correlation coefficient values were high (range 0.89–0.96) for each domain. <h3>Conclusions</h3> The AAV-PRO, a new disease-specific PRO measure for AAV, has good face and construct validity, is reliable, feasible and discriminates among disease states.
International experience of vedolizumab in primary sclerosis cholangitis and inflammatory bowel disease
Authors: K. Williamson, E. Lytvyak, A.E. Kremer, M. de Krijger, P. Trivedi, D. Estes, L. Yu, D. Pratt, A. de Vries, K.K. Yimam, L. Daretti, C.H. Liu, C. Bowlus, M. Vetter, H.-U. Marschall, A. Montano-Loza, R.W.G. Chapman, M. Marzioni, S. Keshav, C. Ponsioen, G. Hirschfield, C. Levy
Journal: Journal of Hepatology (2018)
Pertinence of liver stiffness measurement inpatients with Wilson’s disease for assessment of initial fibrosis and treatment follow-up
Authors: R. Sobesky, M. Darce, H. Agostini, I. Fernandez, A. Usardi, R. Adam, D. Cherqui, E. Gonzales, E. Jacquemin, D. Samuel, A. Poujois, F. Woimant, J.-C. Duclos-Vallée
Journal: Journal of Hepatology (2018)
Clinical, trichoscopic, and histopathologic characteristics of patients with alopecia and hypothyroidism: An observational study
Authors: Sergio Enrique Leal-Osuna, Diana Emma Becerril-Parra, Fátima Tinoco-Fragoso, Ana Beatriz García-Gil, María Elisa Vega-Memije, Lorena Lammoglia-Ordiales
Journal: Journal of the American Academy of Dermatology (2018)
A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health
Authors: Manuel Rodriguez-Concepcion, Javier Avalos, M. Luisa Bonet, Albert Boronat, Lourdes Gomez-Gomez, Damaso Hornero-Mendez, M. Carmen Limon, Antonio J. Meléndez-Martínez, Begoña Olmedilla-Alonso, Andreu Palou, Joan Ribot, Maria J. Rodrigo, Lorenzo Zacarias, Changfu Zhu
Journal: Progress in Lipid Research (2018)
CD19 CAR-T cell therapy for relapsed/refractory acute lymphoblastic leukemia: factors affecting toxicities and long-term efficacies
Authors: Li-Na Zhang, Yongping Song, Delong Liu
Journal: Journal of Hematology & Oncology (2018)

The prognosis of adults with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) remains dismal even at this day and age. With salvage chemotherapy, only 29% (range 18 to 44%) of the patients with R/R ALL can be induced into complete remission (CR), with a median overall survival (OS) of 4 months (range 2–6 months). Blinatumomab and inotuzumab ozogamycin (IO) are immunotherapeutic agents that increased CR to 80% and extended survival to 7.7 months in this high-risk population of patients. In the last few years, chimeric antigen receptor (CAR)––engineered T cells have led to major progress in cancer immunotherapy. CD-19 CAR-T cells have been recently approved for high-risk R/R ALL and lymphoma. The data from long-term follow-up of a single-center phase I study of 19-28z CAR-T cell therapy for adult R/R ALL were just published. At the same time, a multicenter phase II study of 19-41BB CAR-T cell therapy for children and young adults with R/R B cell ALL was also published. The two studies provided fresh information with long-term follow-up. This research highlight analyzed the data and proposed future perspectives for further investigation in this rapidly evolving field.
Response by Liu and Li to Letter Regarding Article, “Dextrocardia: Why Significant Left Axis Deviation?”
Authors: Renguang Liu, Yuhong Li
Journal: Circulation (2018)

atrium enlargement, with diameters of 42 mm and 48 mm, respectively.The effect of single ventricle on left and right atrium is determined by other coexisting congenital anatomic abnormalities and cardiac function.Echocardiography revealed mirrorimage dextrocardia accompanied with single ventricle and transposition of the great arteries, moderate mitral and tricuspid regurgitation, and severe pulmonary hypertension; consequently, the ECG of this patient has a clear manifestation of right atrium enlargement.