tbuckley/cabot-search huggingface dataset:
USPTF Prostate Cancer Screening Recommendations—A Step in the Right Direction
Authors: Peter R. Carroll
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer
Authors: Jacqulyne P. Robichaux, Yasir Y. Elamin, Zhi Tan, Brett W. Carter, Shuxing Zhang, Shengwu Liu, Shuai Li, Ting Chen, Alissa Poteete, Adriana Estrada-Bernal, Anh T. Le, Anna Truini, Monique B. Nilsson, Huiying Sun, Emily Roarty, Sarah B. Goldberg, Julie R. Brahmer, Mehmet Altan, Charles Lu, Vassiliki Papadimitrakopoulou, Katerina Politi, Robert C. Doebele, Kwok-Kin Wong, John V. Heymach
Journal: Nature Medicine (2018)
The PR interval in the fetal electrocardiogram is significantly prolonged in severe intrahepatic cholestasis of pregnancy and potentially normalised by UDCA therapy
Authors: T. Vasavan, C. Martin, I.A. Jayawardane, S. Deepak, V. Geenes, M. Lucchini, J. Chambers, L. Kurlak, J. Thornton, F. Broughton-Pipkin, B. Hayes-Gill, W. Fifer, C. Williamson
Journal: Journal of Hepatology (2018)
Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal–Regulating Kinase 1
Authors: Peng Sun, Qiang Zeng, Daqing Cheng, Kuo Zhang, Jilin Zheng, Yupeng Liu, Yu‐Feng Yuan, Yi‐Da Tang
Journal: Hepatology (2018)

The rapidly increasing prevalence of metabolic disorders associated with nonalcoholic fatty liver disease (NAFLD) warrants further study of the underlying mechanisms to identify key regulators as targets for the development of therapeutic interventions. Caspase recruitment domain protein 6 (Card6), as a member of the CARD family that regulates cell death and immunity, may potentially control this process. Indeed, Card6 down‐regulation was found to be closely associated with the fatty livers observed in NAFLD patients, obese mice, and a palmitate‐treated hepatocyte model. Gain‐of‐function and loss‐of‐function Card6 mouse models demonstrated that Card6 protected mice from insulin resistance, hepatic steatosis, and inflammatory responses upon high‐fat diet administration. Mechanistically, Card6 interacted with and inhibited apoptosis signal–regulating kinase 1 (Ask1) and its subsequent downstream c‐Jun N‐terminal kinase/p38 signaling. Furthermore, Ask1 was sufficient to mediate Card6 function, and the interaction between Ask1 and Card6 was absolutely required for Card6 function in vivo . Adenovirus‐mediated Card6 overexpression in the liver effectively ameliorated insulin resistance and hepatic steatosis in ob/ob mice. Therefore, we identified Card6 as an important negative regulator in NAFLD. Conclusion: Targeting Ask1 by Card6 may be a good strategy to develop a therapeutic method against NAFLD.
Rates and predictors of HBsAg loss after discontinuation of effective long-term Entecavir or Tenofovir therapy in noncirrhotic HBeAg-negative chronic hepatitis B patients: Results from the DARING-B prospective Greek study
Authors: M. Papatheodoridis, E. Rigopoulou, E. Hadziyannis, Z. Kalliopi, V. Xourafas, A. Lyberopoulou, N. Gatselis, I. Vlachogiannakos, S. Manolakopoulos, G. Dalekos, G. Papatheodoridis
Journal: Journal of Hepatology (2018)
Chronic Diseases and Health Monitoring Big Data: A Survey
Authors: Rongheng Lin, Zezhou Ye, Hao Wang, Budan Wu
Journal: IEEE Reviews in Biomedical Engineering (2018)

With the advancement of technology in data science and network technology, the world has stepped into the Era of Big Data, and the medical field is rich in data suitable for analysis. Thus, in recent years, there has been much research in medical big data, mainly targeting data collection, data analysis, and visualization. However, very few works provide a full survey of the medical big data on chronic diseases and health monitoring. This review investigates recent research efforts and conducts a comprehensive overview of the work on medical big data, especially as related to chronic diseases and health monitoring. It focuses on the full cycles of the big data processing, which includes medical big data preprocessing, big data tools and algorithms, big data visualization, and security issues in big data. It also attempts to combine common big data technologies with special medical needs by analyzing in detail existing works of medical big data. To the best of our knowledge, this is the first survey that targets chronic diseases and health monitoring big data technologies.
High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis
Authors: Daniele Avanzato, Emanuela Pupo, Nadia Ducano, Claudio Isella, Giovanni Bertalot, Chiara Luise, Salvatore Pece, Alejandra Bruna, Oscar M. Rueda, Carlos Caldas, Pier Paolo Di Fiore, Anna Sapino, Letizia Lanzetti
Journal: Cancer Research (2018)

Abstract USP6NL, also named RN-tre, is a GTPase-activating protein involved in control of endocytosis and signal transduction. Here we report that USP6NL is overexpressed in breast cancer, mainly of the basal-like/integrative cluster 10 subtype. Increased USP6NL levels were accompanied by gene amplification and were associated with worse prognosis in the METABRIC dataset, retaining prognostic value in multivariable analysis. High levels of USP6NL in breast cancer cells delayed endocytosis and degradation of the EGFR, causing chronic AKT (protein kinase B) activation. In turn, AKT stabilized the glucose transporter GLUT1 at the plasma membrane, increasing aerobic glycolysis. In agreement, elevated USP6NL sensitized breast cancer cells to glucose deprivation, indicating that their glycolytic capacity relies on this protein. Depletion of USP6NL accelerated EGFR/AKT downregulation and GLUT1 degradation, impairing cell proliferation exclusively in breast cancer cells that harbored increased levels of USP6NL. Overall, these findings argue that USP6NL overexpression generates a metabolic rewiring that is essential to foster the glycolytic demand of breast cancer cells and promote their proliferation. Significance: USP6NL overexpression leads to glycolysis addiction of breast cancer cells and presents a point of metabolic vulnerability for therapeutic targeting in a subset of aggressive basal-like breast tumors. Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/78/13/3432/F1.large.jpg. Cancer Res; 78(13); 3432–44. ©2018 AACR.
Exploring Radiotherapy Targeting Strategy and Dose: A Pooled Analysis of Cooperative Group Trials of Combined Modality Therapy for Stage III NSCLC
Authors: Steven E. Schild, Herbert H. Pang, Wen Fan, Thomas E. Stinchcombe, Everett E. Vokes, Suresh S. Ramalingam, Jeffrey D. Bradley, Karen Kelly, Xiaofei Wang
Journal: Journal of Thoracic Oncology (2018)
Influence of Myocardial Hemorrhage on Staging of Reperfused Myocardial Infarctions With T2 Cardiac Magnetic Resonance Imaging
Authors: Guan Wang, Hsin-Jung Yang, Avinash Kali, Ivan Cokic, Richard Tang, Guoxi Xie, Qi Yang, Joseph Francis, Songbai Li, Rohan Dharmakumar
Journal: JACC. Cardiovascular imaging (2018)

This study sought to determine whether T2 cardiac magnetic resonance (CMR) can stage both hemorrhagic and nonhemorrhagic myocardial infarctions (MIs).CMR-based staging of MI with or without contrast agents relies on the resolution of T2 elevations in the chronic phase, but whether this approach can be used to stage both hemorrhagic and nonhemorrhagic MIs is unclear.Hemorrhagic (n = 15) and nonhemorrhagic (n = 9) MIs were created in dogs. Multiparametric noncontrast mapping (T1, T2, and T2*) and late gadolinium enhancement (LGE) were performed at 1.5- and 3.0-T at 5 days (acute) and 8 weeks (chronic) post-MI. CMR relaxation values and LGE intensities of hemorrhagic, peri-hemorrhagic, nonhemorrhagic, and remote territories were measured. Histopathology was performed to elucidate CMR findings.T2 of nonhemorrhagic MIs was significantly elevated in the acute phase relative to remote territories (1.5-T: 39.8 ± 12.8%; 3.0-T: 27.9 ± 16.5%; p < 0.0001 for both) but resolved to remote values by week 8 (1.5-T: -0.0 ± 3.2%; p = 0.678; 3.0-T: -0.5 ± 5.9%; p = 0.601). In hemorrhagic MI, T2 of hemorrhage core was significantly elevated in the acute phase (1.5-T: 17.7 ± 10.0%; 3.0-T: 8.6 ± 8.2%; p < 0.0001 for both) but decreased below remote values by week 8 (1.5-T: -8.2 ± 3.9%; 3.0-T: -5.6 ± 6.0%; p < 0.0001 for both). In contrast, T2 of the periphery of hemorrhage within the MI zone was significantly elevated in the acute phase relative to remote territories (1.5-T: 35.0 ± 16.1%; 3.0-T: 24.2 ± 10.4%; p < 0.0001 for both) and remained elevated at 8 weeks post-MI (1.5-T: 8.6 ± 5.1%; 3.0-T: 6.0 ± 3.3%; p < 0.0001 for both). The observed elevation of T2 in the peri-hemorrhagic zone of MIs and the absence of T2 elevation in nonhemorrhagic MIs were consistent with ongoing or absence of histological evidence of inflammation, respectively.Hemorrhagic MIs are associated with persisting myocardial inflammation and edema, which can confound staging of hemorrhagic MIs when T2 elevations alone are used to discriminate between acute and chronic MI. Moreover, given the poor prognosis in patients with hemorrhagic MI, CMR evidence for myocardial hemorrhage with persistent edema may evolve as a risk marker in patients after acute MI.
Comorbid disease burden in patients with primary liver pathologies-data from a comprehensive analysis of serial transient elastography and other liver disease evaluations at the Toronto liver centre (CASTLE-TLC)
Authors: M. Elkashab, H. Dallali, S. Kausar, M. Farshadi, M. Khurram, O. Muraru, M. Khan, J. Palmart, S. Loo, M. Magnes, K. Boctor
Journal: Journal of Hepatology (2018)
P68Cardiomyocyte cell cycle activity and function is under the control of miR-125a
Authors: R Verjans, L Braga, M Rech, S Beijnsberger, P Carai, R Spatjens, M Van Bilsen, M Giacca, B Schroen
Journal: Cardiovascular Research (2018)

Background: Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes are currently emerging as a valuable experimental platform in cardiovascular research.Despite being widely used as an alternative for animal models to study disease specific drug responses, fully functional and mature cardiomyocytes suitable for drug discovery and toxicity screenings remain to be developed.Purpose: Using the CRISPR-Cas9 genome editing strategy, we generated a cardiac specific hiPSC fluorescent reporter line for real-time monitoring of cardiomyocyte differentiation from hiPSCs.This reporter line offer a promising tool to isolate a purified population of cardiomyocytes and will provide better insights in the biology and function of hiPSC-derived cardiomyocytes.Method: The myosin heavy chain locus (MYH6), enocoding a cardiac muscle specific protein, is targeted before the stop codon by knocking-in a bicistronic 2A-mScarlet reporter cassette carrying an excisable selection marker (PGK-Puro) using homologous recombination.For validating the reporter activity, a homozygous reporter iPS clone free of predicted off-target mutations and a normal karyotype was differentiated to cardiomyocytes by both mouse visceral endodermal-like (END-2) co-culture method and small molecule differentiation method.Immunostaining of the mature cardiac markers, Ca2þ imaging and action potential measurements by conventional patch clamping functionally characterized the reporter hiPSC-derived cardiomyocytes.Result: The expression profile of the mScarlet fluorescent reporter monitored during the course of cardiomyocyte differentiation by a time-lapse incubator imaging system demonstrate a faithful cardiac reporter activity of the CRISPR engineered hiPSC reporter line.Beating areas expressing mScarlet fluorescent protein was observed at day 14 for END-2 differentiation and day 10 for small molecule differentiation method.Video-based beating analysis, Ca2þ handling properties and electrophysiological measurements of the disassociated cardiomyocytes confirmed the functional use of this reporter line to define cardiac cell lineage.
HPV vaccines are effective and safe and work best in young women, review finds
Authors: Nigel Hawkes
Journal: BMJ (2018)

Human papillomavirus (HPV) vaccines are effective against pre-cancerous changes that could lead to cervical cancer, and they cause no serious side effects, a Cochrane review has found.1

The reassuring conclusions, based on 26 studies involving 73 428 women, confirmed what the vaccine trials had shown—that these vaccines are a powerful tool in reducing deaths from cervical cancer. They work best if given to young women who are free of HPV at the time of vaccination, almost eliminating cervical lesions, but they also approximately halve this risk in women aged 15-26 who are already infected with HPV.

Because insufficient time has passed no trials have yet shown an effect on cervical cancer deaths, but the well established course of the disease justifies the use …
Transcatheter recanalization with angioplasty and/or stenting: a novel, minimally-invasive treatment option for children with chronic portal vein thrombosis with cavernous transformation
Authors: H. Justino, K. Kukreja, J.A. Hernandez, Y. Pham, S. Harpavat, L. Karam, P. Hertel, B. Carter, B. Shneider, T. Miloh
Journal: Journal of Hepatology (2018)
P494Applying proteomic tools to disclose human cardiac stem cells regenerative potential in ischemia/reperfusion injury
Authors: M Sebastiao, M Paiva, I Reis, M Sousa, I Palacios, M Serra, P Gomes-Alves, P M Alves
Journal: Cardiovascular Research (2018)

After an Acute Myocardial Infarction (AMI), Ischemia-Reperfusion (I/R) injury is responsible for a critical decrease in the number of viable cardiomyocytes (hCMs).Human myocardium harbors a population of endogenous cardiac stem/progenitor cells (hCSCs) that is activated upon I/R injury, contributing to myocardial repair through the establishment of an auto/paracrine molecular crosstalk between hCSCs and hCMs in stress.Clinical trials involving transplantation of hCSCs into the infarcted myocardium have demonstrated the potential of these cells.Although some improvements have been reported regarding increase in viable myocardium and improved tissue contractility, extensive data indicates that transplanted cells do not survive in the myocardium and this has led to the postulation of a paracrine mechanism for the observed beneficial effects.Using the same cells currently employed in the allogenous hCSCs transplantation clinical trial CARE-MI (EUDRA 2013-001358-81), our work aims at setting up an in vitro human I/R injury model using by using 3D culture approached combined with stirred tank bioreactor technology, in order to better decipher the mechanisms of action of hCSCs upon AMI using proteomic tools.By using aggregates of cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) and a microcarreir based culture of hCSCs, injury setup was performed in bioreactors, allowing paracrine crosstalk between the two cell types via a reciprocal medium exchange via a perfusion system.Ischemia was mimicked by substituting growth media by Ischemia Mimetic Solution and placing the cells at 0% O2 for 5 hours.In the reperfusion step, cells were placed back in their physiological culture conditions (3% O2).The effect of I/R injury in hCSCs was accessed by quantitative total proteome analysis (using LC-MS) at different time points.Growth factor secretion, cells' viability, as well as hCSCs proliferation was also monitored in this co-culture system.Our first experiments in monolayer static systems showed that this model is able to recapitulate important features of I/R, including hCSC proliferation activation and a protective effect of hCSCs in hiPSC-CMs survival.Upon injury, proteome of hCSCs was enriched in proteins related to cell cycle regulation inhibition, proliferation through EGF signaling, gluthathione-mediated reactive oxygen species detoxification and paracrine signalling pathways.This system will allow further understanding on the molecular landscape of the myocardium during AMI, namely regarding hCSCs regenerative response and hCMs survival.The knowledge generated in this work will hopefully potentiate the development of novel molecular and cell-based therapies for myocardium regeneration.
Making Sense of Triple Inhaled Therapy for COPD
Authors: Samy Suissa, Jeffrey M. Drazen
Journal: New England Journal of Medicine (2018)

Guidelines for the treatment of chronic obstructive pulmonary disease (COPD) have consistently recommended long-acting inhaled bronchodilators — either long-acting muscarinic antagonists (LAMAs) or long-acting inhaled beta-agonists (LABAs) — as initial maintenance therapy. If disease control is not achieved, as manifested by inadequate lung function and disease exacerbations, guidelines recommend their combined use.1 Although there is general agreement about the role of LAMAs and LABAs in the treatment of COPD, the role for inhaled glucocorticoids in this treatment guideline has been the object of much debate because of their modest effectiveness and concerns about safety, particularly the risk of pneumonia.2 The . . .
TCTAP C-085 The Stepwise Performing Percutaneous Coronary Intervention in Calcified Chronic Total Occlusion Lesion with Rich Collateral Using Simple Tool: Impossible or I'm Possible?
Authors: Johan Senihardja, Evan Jim Gunawan, Janry Anton Pangemanan, Vika Candra, Hendro Adi Kuncoro, Benny Mulyanto Setiadi, Agnes Lucia Panda
Journal: Journal of the American College of Cardiology (2018)
National Institutes of Health Pathways to Prevention Workshop: Methods for Evaluating Natural Experiments in Obesity
Authors: Karen M. Emmons, Chyke A. Doubeni, Maria E. Fernandez, Diana L. Miglioretti, Jonathan M. Samet
Journal: Annals of Internal Medicine (2018)

On 5 and 6 December 2017, the National Institutes of Health (NIH) convened the Pathways to Prevention Workshop: Methods for Evaluating Natural Experiments in Obesity to identify the status of methods for assessing natural experiments to reduce obesity, areas in which these methods could be improved, and research needs for advancing the field. This article considers findings from a systematic evidence review on methods for evaluating natural experiments in obesity, workshop presentations by experts and stakeholders, and public comment. Research gaps are identified, and recommendations related to 4 key issues are provided. Recommendations on population-based data sources and data integration include maximizing use and sharing of existing surveillance and research databases and ensuring significant effort to integrate and link databases. Recommendations on measurement include use of standardized and validated measures of obesity-related outcomes and exposures, systematic measurement of co-benefits and unintended consequences, and expanded use of validated technologies for measurement. Study design recommendations include improving guidance, documentation, and communication about methods used; increasing use of designs that minimize bias in natural experiments; and more carefully selecting control groups. Cross-cutting recommendations target activities that the NIH and other funders might undertake to improve the rigor of natural experiments in obesity, including training and collaboration on modeling and causal inference, promoting the importance of community engagement in the conduct of natural experiments, ensuring maintenance of relevant surveillance systems, and supporting extended follow-up assessments for exemplar natural experiments. To combat the significant public health threat posed by obesity, researchers should continue to take advantage of natural experiments. The recommendations in this report aim to strengthen evidence from such studies.
Asthma‐<scp>COPD</scp> Overlap Syndrome among subjects with newly diagnosed adult‐onset asthma
Authors: Y.‐C. Wang, M. S. Jaakkola, T. K. Lajunen, C.‐H. Lai, J. J. K. Jaakkola
Journal: Allergy (2018)

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Will Posting Nutritional Information on Menus Prod Diners to Make Healthier Choices?
Authors: Rita Rubin
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCTAP A-150 Outcomes of Percutaneous Coronary Intervention with Drug-eluting Stent in Patients with Total Occlusive In-stent Restenosis
Authors: Yong-Hoon Yoon, Sang Yong Om, Minsoo Kim, Hanbit Park, Sang-Cheol Cho, Osung Kwon, Kyusup Lee, Do-Yoon Kang, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2018)
A nomogram with sarcopenia surpasses the MELD score in predicting waiting list mortality in cirrhotic liver transplant patients: a competing risk analysis in a national cohort
Authors: J. van Vugt, L. Alferink, S. Buettner, M. Gaspersz, D. Bot, S.D. Murad, S. Feshtali, P. van Ooijen, W. Polak, R. Porte, B.V. Hoek, A. van den Berg, H. Metselaar, J. Ijzermans
Journal: Journal of Hepatology (2018)