tbuckley/cabot-search huggingface dataset:
Glioblastoma stem cell differentiation into endothelial cells evidenced through live-cell imaging
Authors: Xin Mei, Yin-Sheng Chen, Fu-Rong Chen, Shao-Yan Xi, Zhong-Ping Chen
Journal: Neuro-Oncology (2017)

Glioblastoma cell-initiated vascularization is an alternative angiogenesis called vasculogenic mimicry. However, current knowledge on the mechanism of de novo vessel formation from glioblastoma stem cells (GSCs) is limited. Sixty-four glioblastoma samples from patients and 10 fluorescent glioma xenograft samples were examined by immunofluorescence staining for endothelial marker (CD34 and CD31) and glial cell marker (glial fibrillary acidic protein [GFAP]) expression. GSCs were then isolated from human glioblastoma tissue and CD133+/Sox2+ red fluorescent protein-containing (RFP)–GSC-1 cells were established. The ability of these cells to form vascular structures was examined by live-cell imaging of 3D cultures. CD34-GFAP or CD31-GFAP coexpressing glioblastoma-derived endothelial cells (GDEC) were found in 30 of 64 (46.9%) of clinical glioblastoma samples. In those 30 samples, GDEC were found to form vessel structures in 21 (70%) samples. Among 21 samples with GDEC vessels, the CD34+ GDEC vessels and CD31+ GDEC vessels accounted for about 14.16% and 18.08% of total vessels, respectively. In the xenograft samples, CD34+ GDEC were found in 7 out of 10 mice, and 4 out of 7 mice had CD34+ GDEC vessels. CD31+ GDEC were also found in 7 mice, and 4 mice had CD31+ GDEC vessels (10 mice in total). Through live-cell imaging, we observed gradual CD34 expression when cultured with vascular endothelial growth factor in some glioma cells, and a dynamic increase in endothelial marker expression in RFP–GSC-1 in vitro was recorded. Cells expressed CD34 (9.46%) after 6 hours in culture. The results demonstrated that GSCs may differentiate into endothelial cells and promote angiogenesis in glioblastomas.
Sustained Health-Related Quality of Life (HRQoL) Improvement in Newly Diagnosed Multiple Myeloma Patients Treated with Bortezomib/Melphalan/Prednisone Versus Melphalan/Prednisone: Results From the VISTA Trial.
Authors: Ravinder Dhawan, Don Robinson Jr., Juliette Meunier, Antoine Regnault, Kathleen Rosa, Andrew Z Cakana, Helgi van de Velde, Paul G Richardson, Jesús F San Miguel
Journal: Blood (2009)
Long-Term Incidence and Outcome of BCR-ABL Mutations in Patients (pts) with Chronic Myeloid Leukemia (CML) Treated with Imatinib Mesylate - P-Loop Mutations Are Not Associated with Worse Outcome.
Authors: Elias Jabbour, Hagop Kantarjian, Dan Jones, Susan O’Brien, Raja Luthra, Guillermo Garcia-Manero, Francis Giles, Mary Beth Rios, Srdan Verstovsek, Jorge Cortes
Journal: Blood (2004)
Visual effects in anaplastic lymphoma kinase (<i>ALK</i>)-positive advanced non-small cell lung cancer (NSCLC) patients treated with crizotinib.
Authors: Ravi Salgia, Benjamin J. Solomon, Alice Tsang Shaw, D. Ross Camidge, Tracey L. Evans, Dong-Wan Kim, Yuankai Shi, Ji-Youn Han, Tommaso Martino De Pas, Sai-Hong Ignatius Ou, Cynthia Huang Bartlett, Keith D. Wilner, Arlene Reisman, Shrividya Iyer
Journal: Journal of Clinical Oncology (2012)

7596 Background: Crizotinib is an ALK inhibitor indicated in the US for advanced ALK-positive NSCLC. Visual effects reported by patients treated with crizotinib were characterized using the Visual Symptom Assessment Questionnaire (VSAQ). Methods: Patients with previously treated, advanced ALK-positive NSCLC were administered 250 mg BID crizotinib in an ongoing phase II study (PROFILE1005, NCT00932451; Pfizer). Patients completed the VSAQ at day 1 of each 21 day cycle and at end of treatment. The VSAQ has a recall period of 3 weeks and consists of 7 questions assessing presence, frequency, timing, duration and degree of bother of visual effects and their impact on Activities of Daily Living (ADL). The visual effects assessed included appearance of overlapping shadows/after images, flashing lights and streamers/strings/floaters, difficulty adapting to lights and seeing at night. Patients rated degree of bother on a 5-point scale ranging from ‘not at all’ to ‘extremely’. Impact on ADL was measured using a 10-point scale (0: no effect; 10: completely prevented ADL). Frequency analyses were performed. Results: As of June 1 2011, visual effects as identified by VSAQ were reported by 63% (114/182) of patients at cycle 2 (C2), 57% at C3 (85/149), 52% at C4 (64/123) and 41% at C5 (46/112). The most commonly experienced visual events were appearance of flashing lights (C2:81%; C3:82%; C4:84%; C5: 76%), streamers/strings/floaters (C2: 83%; C3:78%; C4: 81%; C5:87%) and overlapping shadows/after images (C2:70%; C3:77%; C4:87%; C5:84%). Most patients reported each event to last ≤1 minute (C2:61%; C3:71%; C4:77%; C5: 70%). Majority of patients reported event frequency at each cycle of &lt; 7 days/wk (50–78%). Patients reported that the visual effects occurred mostly in the morning (52–62%) and/or evening (62–73%). Majority of patients reported that visual effects were not at all or a little bothersome (C2:62%; C3:61%; C4:66%; C5:65%). Majority of patients indicated no or minimal impact on ADL (C2:80%; C3:80%; C4:83%; C5:87%). Conclusions: Visual effects identified by VSAQ in patients treated with crizotinib were frequent, but were reported to be transient with no or minimal impact on ADL.
The lower airway microbiota in early cystic fibrosis lung disease: a longitudinal analysis
Authors: Katherine B Frayman, David S Armstrong, Rosemary Carzino, Thomas W Ferkol, Keith Grimwood, Gregory A Storch, Shu Mei Teo, Kristine M Wylie, Sarath C Ranganathan
Journal: Thorax (2017)

<h3>Rationale</h3> In infants and young children with cystic fibrosis, lower airway infection and inflammation are associated with adverse respiratory outcomes. However, the role of lower airway microbiota in the pathogenesis of early cystic fibrosis lung disease remains uncertain. <h3>Objectives</h3> To assess the development of the lower airway microbiota over time in infants and young children with cystic fibrosis, and to explore its association with airway inflammation and pulmonary function at age 6 years. <h3>Methods</h3> Serial, semi-annual bronchoscopies and bronchoalveolar lavage (BAL) procedures were performed in infants newly diagnosed with cystic fibrosis following newborn screening. Quantitative microbiological cultures and inflammatory marker (interleukin 8 and neutrophil elastase) measurements were undertaken contemporaneously. 16S ribosomal RNA gene sequencing was conducted on stored BAL samples. Spirometry results recorded at 6 years of age were extracted from medical records. <h3>Measurements and main results</h3> Ninety-five BAL samples provided 16S ribosomal RNA gene data. These were collected from 48 subjects aged 1.2–78.3 months, including longitudinal samples from 27 subjects and 13 before age 6 months. The lower airway microbiota varied, but diversity decreased with advancing age. Detection of recognised cystic fibrosis bacterial pathogens was associated with reduced microbial diversity and greater lower airway inflammation. There was no association between the lower airway microbiota and pulmonary function at age 6 years. <h3>Conclusions</h3> In infants with cystic fibrosis, the lower airway microbiota is dynamic. Dominance of the microbiota by recognised cystic fibrosis bacterial pathogens is associated with increased lower airway inflammation, however early microbial diversity is not associated with pulmonary function at 6 years of age.
Post-Induction-BM Status Combining Minimal Residual Disease, Return to MDS and Hematogones in Predicting Prognosis in Adult AML,
Authors: Sung-Chao Chu, Tso-Fu Wang, Yu-Chieh Su, Ruey-Ho Kao, Yi-Fung Wu, Dian-Kun Li, Szu-Chin Li, Chi-Cheng Li, Michael R. Loken
Journal: Blood (2011)
A VEGF delivery system targeting MI improves angiogenesis and cardiac function based on the tropism of MSCs and layer-by-layer self-assembly
Authors: Ge Liu, Li Li, Da Huo, Yanzhao Li, Yangxiao Wu, Lingqing Zeng, Panke Cheng, Malcolm Xing, Wen Zeng, Chuhong Zhu
Journal: Biomaterials (2017)
SIRPB1 Is a Strong Predictor Biomarker of Response to 5-Azacitidine Therapy in MDS and AML Patients
Authors: Viviana Guadagnuolo, Cristina Papayannidis, Ilaria Iacobucci, Antonella Padella, Giorgia Simonetti, Stefania Paolini, Mariachiara Abbenante, Sarah Parisi, Francesca Volpato, Chiara Sartor, Maria Chiara Fontana, Emanuela Ottaviani, Anna Ferrari, Nicoletta Testoni, Carmen Baldazzi, Massimo Delledonne, Carla Filì, Michele Malagola, Federica Cattina, Simona Bernardi, Domenico Russo, Giovanni Martinelli
Journal: Blood (2014)
Association between Cardiorespiratory Fitness and Lung Health from Young Adulthood to Middle Age
Authors: Lillian R. Benck, Michael J. Cuttica, Laura A. Colangelo, Stephen Sidney, Mark T. Dransfield, David M. Mannino, David R. Jacobs, Cora E. Lewis, Na Zhu, George R. Washko, Kiang Liu, Mercedes R. Carnethon, Ravi Kalhan
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Rationale: Beyond the risks of smoking, there are limited data on factors associated with change in lung function over time.Objectives: To determine whether cardiorespiratory fitness was longitudinally associated with preservation of lung health.Methods: Prospective data were collected from 3,332 participants in the Coronary Artery Risk Development in Young Adults study aged 18–30 in 1985 who underwent treadmill exercise testing at baseline visit, and 2,735 participants with a second treadmill test 20 years later. The association between cardiorespiratory fitness and covariate adjusted decline in lung function was evaluated.Measurements and Main Results: Higher baseline fitness was associated with less decline in lung function. When adjusted for age, height, race-sex group, peak lung function, and years from peak lung function, each additional minute of treadmill duration was associated with 1.00 ml/yr less decline in FEV1 (P < 0.001) and 1.55 ml/yr less decline in FVC (P < 0.001). Greater decline in fitness was associated with greater annual decline in lung function. Each 1-minute decline in treadmill duration between baseline and Year 20 was associated with 2.54 ml/yr greater decline in FEV1 (P < 0.001) and 3.27 ml/yr greater decline in FVC (P < 0.001). Both sustaining higher and achieving relatively increased levels of fitness over 20 years were associated with preservation of lung health.Conclusions: Greater cardiopulmonary fitness in young adulthood, less decline in fitness from young adulthood to middle age, and achieving increased fitness from young adulthood to middle age are associated with less decline in lung health over time.Clinical trial registered with www.clinicaltrials.gov (NCT 00005130).
Obinutuzumab (GA101) Significantly Enhances Cell Death and ADCC Compared to Rituximab Against CD20+ sensitive and Rituximab Resistant B-Cell Non-Hodgkin Lymphoma (NHL) and Lymphoblastic Leukemia (BLL)
Authors: Aradhana Awasthi Tiwari, Janet Ayello, Carmella van de Ven, Danielle Glassman, Anthony Sabulski, Matthew J. Barth, Mitchell S. Cairo
Journal: Blood (2012)
Annals Story Slam - Everyday Wow
Authors: Lorenita Lucas
Journal: Annals of Internal Medicine (2017)

Web Exclusives7 March 2017Annals On Being a Doctor Story Slam - Everyday WowFREELorenita LucasLorenita LucasFrom Washington, DC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W17-0026 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - Everyday Wow "Everyday Wow," by Lorenita Lucas (Duration 4:44)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: From Washington, DC.Current Author Address: Lorenita Lucas; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 March 2017Volume 166, Issue 5Page: SS1 ePublished: 7 March 2017 Issue Published: 7 March 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.Loading ...
Bortezomib Is Synergistic with Rituximab and Cyclophosphamide in Inducing Apoptosis of Mantle Cell Lymphoma Cells In Vitro and In Vivo.
Authors: Liang Zhang, Yuankai Shi, Xiaohong Han, Jing Yang, Jianfei Qian, Larry W. Kwak, Jorge Romaguera, Qing Yi, Michael Wang
Journal: Blood (2007)
Screening Pelvic Examinations
Authors: George F. Sawaya
Journal: JAMA Internal Medicine (2017)

US Preventive Services Task Force; Kirsten Bibbins-Domingo, PhD, MD, MAS; David C. Grossman, MD, MPH; Susan J. Curry, PhD; Michael J. Barry, MD; Karina W. Davidson, PhD, MASc; Chyke A. Doubeni, MD, MPH; John W. Epling Jr, MD, MSEd; Francisco A. R. García, MD, MPH; Alex R. Kemper, MD, MPH, MS; Alex H. Krist, MD, MPH; Ann E. Kurth, PhD, RN, MSN, MPH; C. Seth Landefeld, MD; Carol M. Mangione, MD, MSPH; William R. Phillips, MD, MPH; Maureen G. Phipps, MD, MPH; Michael Silverstein, MD, MPH; Melissa Simon, MD, MPH; Albert L. Siu, MD, MSPH; Chien-Wen Tseng, MD, MPH, MSEE
Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017
Authors: Heli Harvala, Dan Frampton, Paul Grant, Jade Raffle, Ruth Bridget Ferns, Zisis Kozlakidis, Paul Kellam, Deenan Pillay, Andrew Hayward, Eleni Nastouli
Journal: Eurosurveillance (2017)

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.
Clinical Relevance of Failure to Achieve Early Molecular Response in Chronic Myeloid Leukemia in Chronic Phase
Authors: Ji Yun Lee, Sung Hee Lim, Hae Su Kim, Kwai Han Yoo, Haa-Na Song, Jinhyun Cho, Silvia Park, Seok Jin Kim, Won Seog Kim, Kihyun Kim, Jun Ho Jang, Chul Won Jung
Journal: Blood (2015)
Introduction to the special focus issue on the impact of diet on gut microbiota composition and function and future opportunities for nutritional modulation of the gut microbiome to improve human health
Authors: Sharon M. Donovan
Journal: Gut Microbes (2017)

Over the past decade, application of culture-independent, next generation DNA sequencing has dramatically enhanced our understanding of the composition of the gut microbiome and its association with human states of health and disease. Host genetics, age, and environmental factors such as where and who you live with, use of pre-, pro- and antibiotics, exercise and diet influence the short- and long-term composition of the microbiome. Dietary intake is a key determinant of microbiome composition and diversity and studies to date have linked long-term dietary patterns as well as short-term dietary interventions to the composition and diversity of the gut microbiome. The goal of this special focus issue was to review the role of diet in regulating the composition and function of the gut microbiota across the lifespan, from pregnancy to old age. Overall dietary patterns, as well as perturbations such as undernutrition and obesity, as well as the effects of dietary fiber/prebiotics and fat composition are explored.
Lower levels of vitamin A are associated with increased gastrointestinal graft-versus-host disease in children
Authors: Dana T. Lounder, Pooja Khandelwal, Christopher E. Dandoy, Sonata Jodele, Michael S. Grimley, Gregory Wallace, Adam Lane, Cynthia Taggart, Ashley C. Teusink-Cross, Kelly E. Lake, Stella M. Davies
Journal: Blood (2017)
Escalated Dose-Rates of Total Marrow Irradiation (TMI) Combined with Treosulfan and Fludarabine-Based Conditioning Chemotherapy Regimen for Chemosensitive Advanced Multiple Myeloma (MM) Patients Undergoing a Matched Allogeneic Stem-Cell Transplantation: First Results of a Phase I/II Prospective Monocentric Study (TrRaMM TMI)
Authors: Andrea Angelo Assanelli, Francesca Lorentino, Magda Marcatti, Anna Chiara, Tommaso Perini, Maria Teresa Lupo Stanghellini, Fabio Giglio, Mara Morelli, Raffaella Greco, Sara Broggi, Mauro Cattaneo, Jacopo Peccatori, Chiara Bonini, Nadia Di Muzio, Fabio Ciceri
Journal: Blood (2016)
Response of Hodgkin Lymphoma Patients of Different Ethnic Groups to Standard ABVD with or without Involved Field RT.
Authors: Samuel Ofori-Ntow, Bety Ciobanu, Margaret Clare Telfer, Sunita Nathan, Paula Kovarik, Rafid Kouz, Decebal S. Griza, Thomas Lad, R. Catchatourian
Journal: Blood (2007)
Diagnostic Instability and Reversals of Chronic Obstructive Pulmonary Disease Diagnosis in Individuals with Mild to Moderate Airflow Obstruction
Authors: Shawn D. Aaron, Wan C. Tan, Jean Bourbeau, Don D. Sin, Robyn H. Loves, Jenna MacNeil, George A. Whitmore
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Chronic obstructive pulmonary disease (COPD) is a chronic, progressive disease, and reversal of COPD diagnosis is thought to be uncommon.To determine whether a spirometric diagnosis of mild or moderate COPD is subject to variability and potential error.We examined two prospective cohort studies that enrolled subjects with mild to moderate post-bronchodilator airflow obstruction. The Lung Health Study (n = 5,861 subjects; study duration, 5 yr) and the Canadian Cohort of Obstructive Lung Disease (CanCOLD) study (n = 1,551 subjects; study duration, 4 yr) were examined to determine frequencies of (1) diagnostic instability, represented by how often patients initially met criteria for a spirometric diagnosis of COPD but then crossed the diagnostic threshold to normal and then crossed back to COPD over a series of annual visits, or vice versa; and (2) diagnostic reversals, defined as how often an individual's COPD diagnosis at the study outset reversed to normal by the end of the study.Diagnostic instability was common and occurred in 19.5% of the Lung Health Study subjects and 6.4% of the CanCOLD subjects. Diagnostic reversals of COPD from the beginning to the end of the study period occurred in 12.6% and 27.2% of subjects in the Lung Health Study and CanCOLD study, respectively. The risk of diagnostic instability was greatest for subjects whose baseline FEV1/FVC value was closest to the diagnostic threshold, and the risk of diagnostic reversal was greatest for subjects who quit smoking during the study.A single post-bronchodilator spirometric assessment may not be reliable for diagnosing COPD in patients with mild to moderate airflow obstruction at baseline.
Prognostic factors and outcome of atypical and anaplastic meningioma with and without radiation.
Authors: Hannah Yoon, Irene B. Helenowski, Karthikeyan Perumal, MaryAnne H. Marymont, James Chandler, Bernard R. Bendok, Joshua M. Rosenow, Minesh P. Mehta
Journal: Journal of Clinical Oncology (2013)

2083 Background: We evaluated outcome and prognostic factors for high grade meningioma (G2-3) and the role of early post-operative radiotherapy (RT). Methods: From 2000 to 2010, 136 patients were diagnosed with G2-3 meningioma at Northwestern: 124 with atypical (G2) and 12 with anaplastic (G3) meningioma. All were treated with or without RT after initial or subsequent resection. The primary endpoint was progression-free survival (PFS). Results: 21 patients received adjuvant RT, and 115 did not. Median PFS for G2 with and without RT was 68 vs.89 mos. Median PFS for G3 with and without RT was not reached=nr (mean 5) vs.60 mos (mean 35). Median PFS for Simpson G1-3 with and without RT was 18 vs.96 mos. Median PFS for Simpson G4 with and without RT was nr (mean 55) vs.59 mos (mean 44). For median follow-up of 33 mos for Simpson G1-3 and 29 mos for G4, recurrence rate for Simpson G1-3 with and without RT was 40 vs.6%, and for Simpson G4 with and without RT, 9 vs.31%. 3-yr OS for G2 with and without RT was 93 vs.94%. 3-yr OS for G3 with and without RT was 80 vs.80%. In multivariate analysis, G3 histology and Simpson grade were predictive for relapse, while brain invasion, mitoses, adjuvant RT, and location of tumor were not. For those who received adjuvant RT, mean dose of external beam radiation (EBRT) in 2 patients was 58 Gy, while mean dose of stereotactic radiosurgery (SRS) in 15 patients was 15 Gy. 51% EBRT patients recurred, while 22% SRS patients recurred (p = 0.45). Median PFS with EBRT was 43 vs.51 mos for SRS (p = 0.34). Patients were maldistributed between the with and without RT arms in terms of brain invasion, extent of resection, and G3 histology. Conclusions: Patients who received RT had lower PFS compared to those who did not; survival was comparable. This may be due to inherent selection bias for patients with more aggressive disease getting adjuvant RT. Our study may be underpowered to determine the true role of RT in G2-3 meningioma. Patients with subtotal resection, Simpson G4, who received RT had fewer recurrences and higher PFS compared to those who did not. 3-yr OS was equivalent in both G2 and G3 tumors with and without RT. G3 histology and Simpson grade were predictive for relapse while brain invasion, mitoses, adjuvant RT, and location of tumor were not.
Radius: A Phase 2, Randomized Trial of Standard of Care (SOC) with or without Midostaurin to Prevent Relapse Following Allogeneic Hematopoietic Stem Cell Transplant (alloHSCT) in Patients (pts) with FLT3-Itd-Mutated Acute Myeloid Leukemia (AML)
Authors: Richard T. Maziarz, Mrinal M Patnaik, Bart L. Scott, Sanjay R. Mohan, Abhinav Deol, Scott D. Rowley, Dennis Dong Hwan Kim, Kelly Haines, Gaetano Bonifacio, Patrice Rine, Hugo F. Fernandez
Journal: Blood (2016)
Abstract B56: Breaching endosomal barriers for carried-mediated intracellular delivery of messenger RNA
Authors: Siddhrath Patel, Gaurav Sahay
Journal: Cancer Research (2017)

Abstract RNA therapeutics represents a new class of modern medicine for targets considered undruggable. Lipid based nanoparticles (LNPs) based platforms remain the most advanced in clinical trials for RNA based drugs. Yet, the lack of mechanistic insights into the cellular trafficking and endosomal escape of nanoparticles has become a major hurdle for efficient intracellular delivery. We have 1) Dissected the productive sites for endosomal escape by utilizing an CRISPR/Cas9 based genetically altered cells targeted against endosomal proteins, that direct nanoparticles towards the early, recycling, late or lysosomal delivery. The disruption of key steps in endocytic trafficking revealed the active sites for endosomal escape 2) Identified novel compounds that improve escape from productive endocytic compartments. These molecules were selected based on their properties of influencing endo/lysosomal system that can trigger endosomal escape. Our investigation reveals that endo/lysosomal transport drives intracellular delivery of LNP delivered mRNA and we were able to pinpoint key stages of endosomal escape using genetically altered cells. Novel compounds that can improve cytosolic delivery of mRNA have been identified and are being further interrogated for their ability to breach endosomal barriers. Our goal is to unlock the mechanisms of carrier-mediated intracellular delivery, unravel productive sites of endosomal escape and identify compounds that enable intracellular mRNA delivery for the treatment of various devastating disorders including cancer. Citation Format: Siddhrath Patel, Gaurav Sahay. Breaching endosomal barriers for carried-mediated intracellular delivery of messenger RNA. [abstract]. In: Proceedings of the AACR Special Conference on Engineering and Physical Sciences in Oncology; 2016 Jun 25-28; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2017;77(2 Suppl):Abstract nr B56.