tbuckley/cabot-search huggingface dataset:
Abstract 15463: Mandibular Advancement Device With Precise Usage Monitor Showed Comparable Cardiovascular Effects as Continuous Positive Airway Pressure Among Patients With Moderate to Severe Sleep Disordered Breathing
Authors: Umpei Yamamoto, Sayaka Soda, Sakiko Handa, Tomotake Tokunou, Mari Nishizaka, Hiroko Tsuda, Shin-ichi Ando
Journal: Circulation (2016)

Introduction: Mandibular advancement device (MAD) has shown better compliance but comparable or reduced improvement in sleep rerated parameters, symptoms and blood pressure than continuous positive...
Abstract 18782: Cardiac-specific Ablation of Ulk1, but not of Atg7, Attenuates Mitochondrial Autophagy in the Heart in Response to Energy Stress <i>(Best of Basic Science Abstract)</i>
Authors: Toshiro Saito, Junichi Sadoshima
Journal: Circulation (2015)

Rationale and Objective: During myocardial ischemia, mitochondria in cardiomyocytes undergo oxidative stress, develop protein damage/dysfunction, and trigger cell death. Dysfunctional mitochondria are eliminated through mitochondrial autophagy (MA). MA is mediated by both Atg7-dependent (conventional) and independent (alternative) mechanisms. We investigated the molecular mechanism mediating MA in response to prolonged myocardial ischemia. Methods and Results: We subjected wild-type, cardiac-specific atg7 KO, and cardiac-specific ulk1 KO mice (WT, atg7cKO, or ulk1cKO, respectively) to 48-hour fasting. The protein level of LC3-II was increased more than 5-fold in WT and ulk1cKO mouse hearts in response to starvation (p&lt;0.05), suggesting that conventional autophagy is induced. LC3-II was not detectable, and p62 was markedly accumulated in atg7cKO mouse hearts, indicating the complete absence of conventional autophagy in atg7cKO mouse hearts. Mitochondrial mass, as evaluated by the mitochondrial DNA content, was significantly increased in ulk1cKO mouse hearts (1.27-fold, p&lt;0.05) in response to fasting, but not in WT nor atg7cKO mouse hearts. Electron microscopic analyses indicated that autophagosomes containing mitochondria were easily detected in WT and atg7cKO, but not in ulk1cKO, mouse hearts after fasting. These results suggest that Ulk1, rather than Atg7, is essential for mediating MA in response to fasting. We also subjected them to prolonged ischemia (2 hours). The size of myocardial infarction/area at risk was significantly greater in ulk1KO mouse hearts (67%, p&lt;0.05) than in WT (37 %) and atg7cKO (40 %) mouse hearts. Although WT and atg7cKO mouse hearts exhibited a significant decrease in the protein level of COXI (0.81- and 0.82-fold, p&lt;0.05) in the ischemic region, ulk1cKO mouse hearts exhibited an increase (1.27-fold, p&lt;0.05). Through electron microscopy, MA was clearly observed at the ischemic area in WT and atg7cKO mouse hearts, but not in ulk1cKO mouse hearts. Conclusions: These results suggest that Ulk1, rather than Atg7, plays an important role in mediating protection of the heart against energy stress by mediating degradation of damaged mitochondria through MA.
Impacto global de la utilización de microcatéter en rendezvous pancreático-biliar guiado por ecoendoscopia en aquellos casos con fracaso inicial en la manipulación de la guía
Authors: D Oyón, J Carrascosa, A Elosua, S López, J Pinto, M Gómez, L Uribarri, A Pueyo, I Fernández-Urién, JJ Vila
Journal: Endoscopy (2017)

Se ha descrito la utilización de microcatéter para drenaje biliar y pancreático con rendezvous guiado por ecoendoscopia (CPES-RV) cuando fracasa inicialmente la manipulación de la guía.
Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
Authors: Krishna C. Vadodaria, Debha N. Amatya, Maria C. Marchetto, Fred H. Gage
Journal: Genome Medicine (2018)

Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.
The Urticaria Control Test as a Tool for Monitoring Chronic Idiopathic/Spontaneous Urticaria Treatment: Results From XTEND-CIU, a 48-Week, Randomized, Placebo-controlled Study
Authors: Allen P. Kaplan, Thomas B. Casale, Jonathan A. Bernstein, Michael Holden, Ahmar Iqbal, Benjamin L. Trzaskoma, Marcus Maurer
Journal: Journal of Allergy and Clinical Immunology (2018)
Research, urban myths and the never ending story
Authors: Tim J Gabbett, Peter Blanch
Journal: British Journal of Sports Medicine (2018)

In the modern technological age, practitioners are exposed to a wealth of information from many diverse sources. Social media has resulted in rapid distribution of research evidence. As soon as an article appears on the journal website, those with the fastest fingers and thumbs will have the paper ‘posted’, ‘tweeted’ or ‘blogged’. Without doubt, social media has assisted researchers to distribute their findings to (hopefully) enhance translation to the ‘real world’. But how well does a single 140-character ‘tweet’ encapsulate the findings of a complete research study (which may range from 3000 to 5000 words)?

Often research evidence is equivocal; for every study there will be another study reporting an opposing view, and quite often, factors other than empirical evidence shape our beliefs.1 Wherever possible, practitioners should examine their beliefs and the sources those beliefs are formed upon. We should try to ascertain what is a hypothesis, what is evidence (myth, story, empirical), and based on the strength of the hypothesis or evidence, how much weight should be placed on each. Below, we have provided some examples of how people obtain information and …
Medical Assistance in Dying—Unanswered Questions—Reply
Authors: Kieran L. Quinn, Allan S. Detsky
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Case of nasogastric tube dysfunction
Authors: Florian Rainer, Guenther Prenner, Lukas Peter Binder, Peter Fickert, Johannes Plank
Journal: Gut (2018)

An elderly female patient was admitted to intensive care for prolonged vasopressor therapy and mechanical ventilation after cardiac arrest and acute percutaneous coronary intervention. Antiplatelet, thyroid hormone replacement and statin therapies were administered through a 14-French nasogastric tube (Nestlé Health Science) and enteral feeding was initiated. Correct position of the nasogastric tube was confirmed radiologically. On the seventh day in the intensive care, our patient was seen to regurgitate soft crumbs into her mouth. The blocked nasogastric tube was removed, but attempts to reinsert another tube failed.Upper GI endoscopy revealed an obstruction of the oesophagus with a milky-yellowish caseous substance 20 cm from the incisors (figure 1). The proximal part of the mass showed a central hole and ring-shaped layers resembling the cut face of a tree trunk.gutjnl;68/2/206/F1F1F1Figure 1Obstruction of the oesophagus with a milky-yellowish caseous substance.What caused the obstruction?How should we manage such a problem?
Abstract 16193: Sport Activity and Sudden Cardiac Death in Women
Authors: Cristina Basso, Stefania Rizzo, Kalliopi Pilichou, Elisa Carturan, Gaetano Thiene
Journal: Circulation (2015)

Background: No specific data are available on the prevalence and characteristics of cardiac sudden death (SCD) during sport activities among young women. Methods and Results: From a prospective 30-year target project on SCD in the young, involving 695 subjects 1-40 years old who died suddenly in the same geographic areas, 649 were due to SCD (196 female, 30%). A total of 76 young adults were competitive athletes and died during or soon after effort (11%). Only 6 (8%) of such events occurred in women (mean age 23±10 yrs, range 12-38), specifically during jogging (2), and swimming, volley, gymnastic and triathlon (one each). Cause of death seemed more likely to be associated with structurally normal heart in women compared with men (50% versus 7%; P&lt;0.01). In particular, while inherited cardiomyopathies (i.e. arrhythmogenic, hypertrophic and dilated) and coronary atherosclerosis are the leading cause in the overall population of athletes (24/76, 32% and 11/76, 14.5% respectively) and in the male sub-group (24/70, 34% and 11/70, 16%, respectively), they were never observed in female athletes. Conclusions: Sports-related SCD in women is dramatically less common compared with men. In the female athletic population, SCD occurs in the setting of a structurally normal heart in half of cases. In a country with obligatory pre-participation screening for sport activity, inherited cardiomyopathies and atherosclerotic coronary artery diseases are almost exclusive of the male athletic population.
Childhood Maltreatment in Women with Borderline Personality Disorder, Chronic Depression, and Episodic Depression, and in Healthy Controls
Authors: Eva-Lotta Brakemeier, Jana Dobias, Julia Hertel, Martin Bohus, Matthias F. Limberger, Elisabeth Schramm, Martina Radtke, Patrick Frank, Frank Padberg, Lena Sabass, Andrea Jobst, Gitta A. Jacob, Nele Struck, Johannes Zimmermann, Claus Normann
Journal: Psychotherapy and Psychosomatics (2018)
Effects of the “Living well with COPD” intervention in primary care: a comparative study
Authors: Claudia Steurer-Stey, Kaba Dalla Lana, Julia Braun, Gerben ter Riet, Milo A. Puhan
Journal: European Respiratory Journal (2018)

The pivotal objective of chronic obstructive pulmonary disease (COPD) self-management programmes is behaviour change to avoid moderate and severe exacerbations and improve health related quality of life. In a prospectively planned, controlled study, COPD patients who participated in the “Living well with COPD” (LWWCOPD) self-management intervention were compared with usual care patients from the primary care COPD Cohort ICE COLD ERIC, who did not receive self-management intervention ( NCT00706602 ) The primary outcome was behaviour change and disease-specific health related quality of life after 1 year. Secondary end-points included exacerbation rates. We calculated mixed linear, zero-inflated negative binomial and logistic regression models and used propensity scores to counteract confounding. 467 patients, 71 from the LWWCOPD and 396 from the usual care cohort, were included. The differences between intervention and control were 0.54 (95% CI 0.13−0.94) on the Chronic Respiratory Questionnaire domain “mastery”, 0.55 (95% CI 0.11−0.99) on “fatigue”, 0.54 (0.14−0.93) on “emotional function” and 0.64 (95% CI 0.14−1.14) on “dyspnoea”. The intervention considerably reduced the risk of moderate and severe exacerbations (incidence rate ratio 0.36, 95% CI 0.25−0.52). Self-management coaching in primary care improves health-related quality of life and lowers exacerbation rates and health care use.
The Nuremberg Code and Informed Consent for Research—Reply
Authors: Jonathan D. Moreno, Ulf Schmidt, Steve Joffe
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Corrected Prevalence of Autism Spectrum Disorder Among US Children and Adolescents
Authors: Guifeng Xu, Lane Strathearn, Buyun Liu, Wei Bao
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4
Authors: Jean-Daniel Lalau, Farshad Kajbaf, Youssef Bennis, Anne-Sophie Hurtel-Lemaire, Frans Belpaire, Marc E. De Broe
Journal: Diabetes Care (2018)

OBJECTIVE This study was conducted to define a safe, effective dose regimen for metformin in moderate and severe chronic kidney disease (CKD; stages 3A/3B and 4, respectively), after the lifting of restrictions on metformin use in patients with diabetes with moderate-to-severe CKD in the absence of prospective safety and efficacy studies. RESEARCH DESIGN AND METHODS Three complementary studies were performed: 1) a dose-finding study in CKD stages 1–5, in which blood metformin concentrations were evaluated during a 1-week period after each dose increase; 2) a 4-month metformin treatment study for validating the optimal metformin dose as a function of the CKD stage (3A, 3B, and 4), with blood metformin, lactate, and HbA1c concentrations monitored monthly; and 3) an assessment of pharmacokinetic parameters after the administration of a single dose of metformin in steady-state CKD stages 3A, 3B, and 4. RESULTS First, in the dose-finding study, the appropriate daily dosing schedules were 1,500 mg (0.5 g in the morning [qam] +1 g in the evening [qpm]) in CKD stage 3A, 1,000 mg (0.5 g qam + 0.5 g qpm) in CKD stage 3B, and 500 mg (qam) in CKD stage 4. Second, after 4 months on these regimens, patients displayed stable metformin concentrations that never exceeded the generally accepted safe upper limit of 5.0 mg/L. Hyperlactatemia (&amp;gt;5 mmol/L) was absent (except in a patient with myocardial infarction), and HbA1c levels did not change. Third, there were no significant differences in pharmacokinetic parameters among the CKD stage groups. CONCLUSIONS Provided that the dose is adjusted for renal function, metformin treatment appears to be safe and still pharmacologically efficacious in moderate-to-severe CKD.
Prospective Study of Cardiac Events during Proteasome Inhibitor Therapy for Relapsed Multiple Myeloma
Authors: Robert Frank Cornell, Bonnie Ky, Brendan M Weiss, Liping Du, Joseph R Carver, Adam D. Cohen, Brian G Engelhardt, Alfred L. Garfall, Stacey A Goodman, Shelton Lacy Harrell, Adetola A. Kassim, Trafina Jadhav, Madan Jagasia, Javid Moslehi, Rupal O'Quinn, Michael R. Savona, David Slosky, Amanda Smith, Edward A. Stadtmauer, Dan T. Vogl, Racquel Innis-Shelton, Adam Waxman, Daniel Lenihan
Journal: Blood (2017)
Outbreak of Salmonella Bovismorbificans associated with the consumption of uncooked ham products, the Netherlands, 2016 to 2017
Authors: Diederik Brandwagt, Cees van den Wijngaard, Anna Dolores Tulen, Annemieke Christine Mulder, Agnetha Hofhuis, Rianne Jacobs, Max Heck, Anjo Verbruggen, Hans van den Kerkhof, Ife Slegers-Fitz-James, Lapo Mughini-Gras, Eelco Franz
Journal: Eurosurveillance (2018)

In January 2017, an increase in reported Salmonella enterica serotype Bovismorbificans cases in the Netherlands was observed since October 2016. We implemented a case–control study to identify the source, including all cases after December 2016. Adjusted odds ratios were calculated using logistic regression analysis. We traced back the distribution chain of suspected food items and sampled them for microbiological analysis. Human and food isolates were sequenced using whole genome sequencing (WGS). From October 2016 to March 2017, 54 S. Bovismorbificans cases were identified. Sequencing indicated that all were infected with identical strains. Twenty-four cases and 37 controls participated in the study. Cases were more likely to have consumed ham products than controls (aOR = 13; 95% CI: 2.0–77) and to have shopped at a supermarket chain (aOR = 7; 95% CI: 1.3–38). Trace-back investigations led to a Belgian meat processor: one retail ham sample originating from this processor tested positive for S. Bovismorbificans and matched the outbreak strain by WGS. All ham products related to the same batch were removed from the market to prevent further cases. This investigation illustrates the importance of laboratory surveillance for all Salmonella serotypes and the usefulness of WGS in an outbreak investigation.
Personal history of keratinocyte carcinoma is associated with reduced risk of death from invasive melanoma in men
Authors: Fengju Song, Steven T. Chen, Xin Li, Jiali Han
Journal: Journal of the American Academy of Dermatology (2018)

Previous studies have found an increased risk for invasive cutaneous melanoma (CM) among those with a history of keratinocyte carcinoma (KC).The aim of this study was to evaluate the risk of CM death after KC.The study was based on the Health Professionals Follow-up Study. A Cox proportional hazards model was used to examine the hazard ratio (HR) of death due to CM associated with personal history of KC among the entire study population (primary analysis) and among participants with invasive CM (secondary analysis), respectively.We documented a total of 908 participants with invasive CM over a total of 0.7 million person-years of follow-up. Among all participants, the risk for development of either lethal or nonlethal invasive CM increased for those with a history of KC. The risk for death due to melanoma based on KC history was not significantly increased, with an HR of 1.53 (95% confidence interval, 0.95-2.46). In the case-only analysis, those with a history of KC had a significantly lower risk for death due to melanoma than those with no such history (HR, 0.60; 95% confidence interval, 0.35-0.94).Because the population covered by the Health Professionals Follow-up Study consists exclusively of male health professionals, the results of this study may not be extended to the entire population.Personal history of KC is associated with a decreased risk for melanoma-specific death among male patients with invasive CM.
Racial and Ethnic Disparities in Interval Colorectal Cancer Incidence
Authors: Stacey A. Fedewa, W. Dana Flanders, Ahmedin Jemal, Chyke A. Doubeni, Michael Goodman
Journal: Annals of Internal Medicine (2018)

Letters2 January 2018Racial and Ethnic Disparities in Interval Colorectal Cancer IncidenceStacey A. Fedewa, PhD, MPH, W. Dana Flanders, MD, DSc, Ahmedin Jemal, DVM, PhD, Chyke A. Doubeni, MD, MPH, and Michael Goodman, MD, MPHStacey A. Fedewa, PhD, MPHAmerican Cancer Society, Atlanta, Georgia (S.A.F., A.J.)Search for more papers by this author, W. Dana Flanders, MD, DScEmory University, Atlanta, Georgia (W.D.F., M.G.)Search for more papers by this author, Ahmedin Jemal, DVM, PhDAmerican Cancer Society, Atlanta, Georgia (S.A.F., A.J.)Search for more papers by this author, Chyke A. Doubeni, MD, MPHUniversity of Pennsylvania, Philadelphia, Pennsylvania (C.A.D.)Search for more papers by this author, and Michael Goodman, MD, MPHEmory University, Atlanta, Georgia (W.D.F., M.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0498 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Drs. Rodriguez and McCarty for their insightful comment and for integrating our findings with their recent work examining racial and ethnic disparities in CRC screening (1). We agree that improving access to CRC screening with evidence-based interventions and ensuring adequate quality are important ways to reduce interval CRC incidence. In addition, PDRs alone may not account for all potential variations in quality, and such patient factors as follow-up on surveillance may play a role.Reference1. Rodriguez N, McCarty TR. Racial and ethnic differences in health behaviors and colorectal cancer screening among United States adults: a 2015 Behavioral Risk Factor Surveillance System analysis. Gastroenterology. 2017;152 Suppl 1 S22-3. CrossrefGoogle Scholar Author, Article, and Disclosure InformationAffiliations: American Cancer Society, Atlanta, Georgia (S.A.F., A.J.)Emory University, Atlanta, Georgia (W.D.F., M.G.)University of Pennsylvania, Philadelphia, Pennsylvania (C.A.D.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-1154. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRacial and Ethnic Disparities in Interval Colorectal Cancer Incidence Stacey A. Fedewa , W. Dana Flanders , Kevin C. Ward , Chun Chieh Lin , Ahmedin Jemal , Ann Goding Sauer , Chyke A. Doubeni , and Michael Goodman Racial and Ethnic Disparities in Interval Colorectal Cancer Incidence Nicolette J. Rodriguez and Thomas R. McCarty Metrics Cited byEpidemiology of Colorectal Cancer 2 January 2018Volume 168, Issue 1Page: 80KeywordsColorectal cancerConflicts of interestDisclosure ePublished: 2 January 2018 Issue Published: 2 January 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Minimally invasive skin tape strip RNA sequencing identifies novel characteristics of the type 2–high atopic dermatitis disease endotype
Authors: Nathan Dyjack, Elena Goleva, Cydney Rios, Byung Eui Kim, Lianghua Bin, Patricia Taylor, Caroline Bronchick, Clifton F. Hall, Brittany N. Richers, Max A. Seibold, Donald Y.M. Leung
Journal: Journal of Allergy and Clinical Immunology (2018)