tbuckley/cabot-search huggingface dataset:
ENDOSCOPIC MANAGEMENT OF THE POST-OPERATIVE LEAKS AFTER A BARIATRIC SURGERY
Authors: G Claudé, B Vedrenne, T Degand, P Claudé, JB Chevaux, L Vuitton, S Koch
Journal: Endoscopy (2018)

The number of bariatric surgeries increased in the past decades. Post-surgical leaks are a major complication of these procedures. The endoscopic strategies of treatment have proven their efficiency, initially using self-expendable metal stents to cover the fistula tract in association with a surgical or radiological drainage. An endoscopic internal drainage using double pigtails stents seemed to be as efficient and better tolerated. The primary aim of this study was to evaluate the efficiency of the endoscopic management and the secondary aims were to evaluate the efficacy of the endoscopic internal drainage, to determine factors associated with a successful treatment.
Capsule endoscopy and deep enteroscopy
Authors: Lauren Gerson
Journal: Endoscopy (2013)

Abbreviations: CO<sub>2</sub>, carbon dioxide; DBE, double-balloon enteroscopy; MGCE, magnetic-guided capsule endoscopy; PC, patency capsule; PEG, polyethylene glycol; SBE, single-balloon enteroscopy; VCE, video capsule endoscopy
Doctors criticise India’s “ill conceived” launch of publicly funded health insurance scheme
Authors: Sanjeet Bagcchi
Journal: BMJ (2018)

The Indian government’s launch of what it claims will be the world’s largest publicly funded health insurance scheme has prompted scepticism and criticism from medical representatives.

The programme—officially called Ayushman Bharat-National Health Protection Mission (AB-NHPM) and popularly known as “Modicare”—aims to provide publicly funded health insurance cover worth 500 000 rupees (£5445; €6220; $7675) per family per year, for 100 million poor families or 500 million people in India.1 Ministers have hailed it as a major step towards universal healthcare in India.

But the Indian Medical Association criticised the …
Apport de la lithotritie extra-corporelle des calculs pancréatiques immédiatement avant le traitement endoscopique de la Pancréatite Chronique Calcifiante
Authors: L Heyries, X Lagrange, JP Bernard, J Sahel
Journal: Endoscopy (2009)

But: Etude pilote de faisabilité de la lithotritie extra-corporelle (LEC) sous anesthésie générale (AG) dans le même temps que la CPRE.
ESOPHAGEAL STENT PLACEMENT FOR DYSPHAGIA PALLIATION IN LUNG CANCER PATIENTS; A TWO YEAR SINGLE CENTER EXPERIENCE
Authors: P Markos, H Ivekovic, B Bilic, N Rustemovic
Journal: Endoscopy (2018)

Aim of the study was to evaluate the role of self-expandable metal stents (SEMS) for palliation of malignant dysphagia in lung cancer patients.
<i>Listeria monocytogenes</i>–Induced Rhombencephalitis in a Patient With Multiple Sclerosis Treated With Dimethyl Fumarate
Authors: Serena Ruggieri, Alessandra Logoteta, Gabriella Martini, Alessandro Bozzao, Laura De Giglio
Journal: JAMA Neurology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
FACTORS INFLUENCING CLINICAL OUTCOME OF PNEUMATIC DILATION IN ACHALASIA – INITIAL RESULTS FROM A TERTIARY CENTRE
Authors: C Puşcaşu, A Voiosu, A Benguş, T Voiosu, B Mateescu
Journal: Endoscopy (2018)

Achalasia is a rare motility disorder of the esophagus that is amenable to multiple modalities of endoscopic treatment. We report on factors influencing the clinical and manometric outcome of graded pneumatic dilation (PD).
TECHNICAL ISSUES (TIS) DURING EUS-GUIDED INSERTION OF LUMEN APPOSING METAL STENTS (LAMS): CLASSIFICATION, ANALYSIS OF THEIR EFFECT ON PROCEDURE OUTCOMES, RISK FACTORS AND SALVAGE TECHNIQUES
Authors: S Sevilla Ribota, J García-Alonso, R Sánchez-Ocaña Hernández, I Peñas Herrero, N Mora, R Torres Yuste, M Cimavilla, S Bazaga Pérez de Rozas, C de la Serna Higueras, M Pérez-Miranda Castillo
Journal: Endoscopy (2018)

LAMS have been recently introduced, presenting promising results in intraabdominal drainages and endoscopic anastomoses. A variety of TIs might appear but we lack a common terminology to address them and their consequences on outcomes are unknown.
Ethics in publication
Authors: Michael Wallace, Peter Siersema
Journal: Endoscopy (2015)

Publication of scientific manuscripts remains our core method of sharing knowledge and advanced scientific inquiry. Pressures to publish for reasons other than pure discovery have the potential to corrupt this process. The core principles of scientific ethics outlined above provide guidance on how to maintain the integrity of our scientific process. We, as journal editors, are committed to the advancement of scientific knowledge and the ethical process of publication. We do the best we can to make sure that the articles we publish fulfill all the criteria of a well-conducted study.
Abstract P200: Elevated Triacylglycerols and Diacylglycerols Had Association With Increased Carotid Arterial Stiffness, Independent of Cvd Risk Factors, in Women With or at High Risk of HIV Infection
Authors: Renato Quispe, Simin Hua, Clary Clish, Justin Scott, Amy Deik, David B Hanna, Kathryn Anastos, Mario J Garcia, Robert Kaplan, Jorge R Kizer, Qibin Qi
Journal: Circulation (2018)

Background: Metabolomics has provided new insights into mechanistic knowledge of CVD. However, this approach has limited use for studying arterial disease in high-risk women with and without HIV infection. Methods: Using liquid chromatography-tandem mass spectrometry, we profiled plasma levels of 114 cationic polar and 211 nonpolar lipid metabolites among 411 women (72% HIV+; 60% Black and 31% Hispanic) aged 35-50 from the Women’s Interagency HIV Study. Carotid arterial distensibility, a direct measure of carotid stiffness, was calculated from ultrasound measurements of the right common carotid artery diameter at systole and diastole and brachial artery pulse pressure measured. We performed partial least squares discriminant analysis (PLS-DA) to identify metabolite clusters associated with carotid stiffness (lowest vs. the other 3 quartiles of distensibility index). We used multivariate linear regression models to examine associations of individual metabolites with the distensibility index. Results: PLS-DA identified two major metabolite clusters associated with carotid stiffness. In the lipid metabolite cluster, triacylglycerols (TAGs 52:3, 52:4, 54:4), diacylglycerols (DAGs 36:2, 36:3) and sphingomyelins (16:1, 18:1, 18:2) were associated with decreased distensibility, while lysophosphatidylcholines (18:2, 20:5) were associated with increased distensibility. In the cationic polar metabolite cluster, urate, C4-OH carnitine, C5-DC carnitine, pseudouridine and 1-methyladenosine were associated with decreased distensibility. The associations of TAGs 52:3, 52:4, 54:4 and DAG 36:3 with carotid stiffness remained significant after further adjustment for conventional CVD risk factors ( Table ). No interaction by HIV infection was found. Conclusions: Among women with or at risk of HIV infection from predominantly race-ethnic minority groups, plasma TAGs and DAG of higher carbon number and double bond content are associated with carotid stiffness independent of conventional CVD risk factors.
CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment
Authors: Jarem Edwards, James S. Wilmott, Jason Madore, Tuba Nur Gide, Camelia Quek, Annie Tasker, Angela Ferguson, Jinbiao Chen, Rehana Hewavisenti, Peter Hersey, Thomas Gebhardt, Wolfgang Weninger, Warwick J. Britton, Robyn P.M. Saw, John F. Thompson, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, Umaimainthan Palendira
Journal: Clinical Cancer Research (2018)

Purpose: Therapeutic blockade of immune checkpoints has revolutionized cancer treatment. Durable responses, however, occur in less than half of those treated, and efforts to improve treatment efficacy are confounded by a lack of understanding of the characteristics of the cells that initiate antitumor immune response.Patients and Methods: We performed multiparameter flow cytometry and quantitative multiplex immunofluorescence staining on tumor specimens from immunotherapy-naïve melanoma patients and longitudinal biopsy specimen obtained from patients undergoing anti-PD-1 therapy.Results: Increased numbers of CD69+CD103+ tumor-resident CD8+ T cells were associated with improved melanoma-specific survival in immunotherapy-naïve melanoma patients. Local IL15 expression levels strongly correlated with these tumor-resident T-cell numbers. The expression of several immune checkpoints including PD-1 and LAG3 was highly enriched in this subset, and these cells significantly expanded early during anti-PD-1 immunotherapy.Conclusions: Tumor-resident CD8+ T-cell numbers are more prognostic than total CD8+ T cells in metastatic melanoma. In addition, they are likely to initiate response to anti-PD-1 and anti-LAG-3 treatments. We propose that the immune profile of these cells prior to treatment could inform strategies for immune checkpoint blockade. Clin Cancer Res; 24(13); 3036-45. ©2018 AACR.
Intérêt de la coloscopie systématique dans l'année suivant une résection chirurgicale pour la prévention de la récidive dans la maladie de Crohn
Authors: C Baudry, V Pacault, M Simon, JM Gornet, P Cattan, N Munoz-Bongrand, E Sarfati, M Allez, M Lémann
Journal: Endoscopy (2009)

Introduction: Différentes stratégies ont été proposées pour la prévention de la récidive après résection pour maladie de Crohn iléocolique. La sévérité de la récidive endoscopique évaluée dans l'année suivant la chirurgie étant prédictive de la récidive clinique, une de ces stratégies consiste à réaliser une iléocoloscopie dans les 12 mois suivant la chirurgie et à adapter le traitement préventif aux résultats endoscopiques. L'applicabilité et l'impact de cette stratégie pour réduire la récidive n'ont pas été réellement évalués.
Exploring diagnostic and therapeutic implications of endoscopic mucosal resection in EUS-staged T2 esophageal adenocarcinoma
Authors: Annieke Gotink, Manon Spaander, Michael Doukas, Thjon Tang, Paul Didden, Bas Wijnhoven, Marco Bruno, Arjun Koch
Journal: Endoscopy (2017)

Abstract Background and study aims Treatment strategies for clinical (c)T2N0M0 esophageal adenocarcinoma (EAC) are subject to debate owing to the relative inaccuracy of tumor staging by endoscopic ultrasound (EUS), with profound implications in overstaged patients. We aimed to evaluate the final histological diagnosis of patients initially staged as having a cT2 tumor by EUS, and to assess the value of endoscopic reassessment by an interventional endoscopist, followed by an endoscopic resection when deemed feasible. Patients and methods Two distinct cohorts of patients with cT2 EAC as determined by EUS were included: a retrospective surgical cohort of patients treated by primary esophagectomy, and a prospective cohort of patients who underwent an endoscopic reassessment by an interventional endoscopist. The main outcome measure was the final pathological (p)T stage. Results We identified 134 patients with stage T2 EAC from the surgical cohort. In 72 patients treated by primary esophagectomy, 32/72 (44 %) were downstaged to a pT1 tumor. In 12/72 (17 %), the surgical resection specimen showed tumor characteristics that fulfilled the current criteria for a curative endoscopic resection. In 13 prospectively identified patients with cT2N0M0 EAC, an expert endoscopic reassessment was done. In 11/13 (85 %) the lesion appeared endoscopically resectable and a complete endoscopic resection was performed. Histology revealed a pT1 tumor in all 11 patients, with 5/13 (38 %) fulfilling current criteria for a curative endoscopic resection. Conclusions In this study, 44 % of cT2 EACs were in fact pT1 tumors. Curative treatment by endoscopic resection was achieved in more than a third of these cases. To avoid an unnecessary esophagectomy, an endoscopic reassessment by an interventional endoscopist is recommended for all patients with cT2N0M0 EAC.
Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study
Authors: Theodore W Laetsch, Steven G DuBois, Leo Mascarenhas, Brian Turpin, Noah Federman, Catherine M Albert, Ramamoorthy Nagasubramanian, Jessica L Davis, Erin Rudzinski, Angela M Feraco, Brian B Tuch, Kevin T Ebata, Mark Reynolds, Steven Smith, Scott Cruickshank, Michael C Cox, Alberto S Pappo, Douglas S Hawkins
Journal: The Lancet Oncology (2018)
INTEREST OF SELFEXPANSIVE METALLIC PROTHESIS IN THE TREATEMENT OF NEOPLASTIC COLIC OCCLUSIONS (ABOUT 27 CASES)
Authors: K Loubaris, H Seddik, S Jamal, H Boutallaka, A Aomari, F Bouhamou, S Morabit, R Berraide, I El Koti, A Benkirane
Journal: Endoscopy (2018)

The treatment of neoplastic colonic obstruction has been modified in recent years thanks to selfexpansive metallic prothesis (SEMP). It is a therapeutic alternative for emergency lifting of colonic obstruction before curative surgery and for the palliative treatment of colonic obstruction in patients who are inoperable or have unresectable tumor. The aim of this work is to evaluate the feasibility, safety and effectiveness of SEMP in the management of occlusive colorectal cancer.
Place de l'échoendoscopie dans l'évaluation préopératoire du lobe gauche avant hépatectomie droite pour métastases hépatiques de cancers colorectaux –étude prospective
Authors: C Sabbagh, D Fuks, JP Joly, ED Nguyen-Khac, T Yzet, A Hanes, JC Duchmann, JC Prevost, F Demuynck, P Verhaeghe, JM Regimbeau
Journal: Endoscopy (2009)

Introduction: L'évaluation préopératoire du lobe gauche est essentielle avant hépatectomie droite (HD) pour métastases hépatiques de cancers colorectaux (MHCCR). L'échoendoscopie (EUS) est fréquemment utilisée pour le bilan locorégional ou pour biopsie de tumeurs pancréatiques et a montré un certain intérêt dans l'analyse du parenchyme du lobe gauche.
TACE combined with apatinib for the treatment of BCLC stage C of hepatocellular carcinoma: A restrospective controlled study.
Authors: Xuefeng Kan, Bin Xiong, Yong Wang, Bin Liang, Guofeng Zhou, Chuansheng Zheng
Journal: Journal of Clinical Oncology (2018)

445 Background: To access the safety and effcacy of transarterial chemoembolization (TACE) combined with apatinib (TACE-apatinib) for the treatment of Barcelona Clinic Liver Cancer (BCLC) stage C of hepatocellular carcinoma (HCC). Methods: The medical records of 290 consecutive patients with BCLC stage C of HCC who underwent TACE-apatinib or TACE-alone from June 2015 to June 2017 were retrospectively reviewed. a-Fetoprotein (AFP) response at 4 weeks after treatment in the two groups were evaluated. Tumor response in the two groups were assessed according to modified Response Evaluation Criteria in Solid Tumors (m-RECIST) criteria. The time to tumor progression (TTP) and overall survival (OS) of patients in the two groups were evaluated respectively. Results: One hundred and ninety patients were included in the analysis; 95 patients underwent TACE-apatinib and 95 underwent TACE-alone. The baseline characteristics of patients between the two groups were comparable. The disease control rate (DCR) of tumor and AFP response in TACE-apatinib group was significantly greater than that of TACE-alone group ( P &lt; 0.001). The median TTP was 14.0 months in the TACE-apatinib group and 3.0 months in the TACE-alone group, and the median OS was 17 months in the TACE-apatinib group and 6.0 months in the TACE-alone group. Apatinib-related adverse events of grade 3 occurred in 14 patients in TACE-apatinib group, and there was no occurrence of grade 4 adverse event. Conclusions: The adverse effects of apatinib were acceptable, and TACE-apatinib improved the outcomes for patients with BCLC stage C of HCC in comparison to TACE-alone.
COLORECTAL CANCER AND ITS STAGES IN SCREENING PROGRAMME IN OUR HOSPITAL. DIFFERENCES BETWEEN MALES AND FEMALES
Authors: G Hontoria Bautista, MA Jimenez Moreno, R Pereda Garcia, J Sanz Sanchez, B Bernad Cabredo, A Moncada Urdaneta, E Badia Aranda, BS Aladren, S Garcia Moran, JL Martin Lorente, F Saez-Royuela Gonzalo
Journal: Endoscopy (2018)

To describe the neopastic findings and stages of colorectal cancer (CRC) in in CCR screening asymptomatic participants.
Ongoing clonal evolution in chronic myelomonocytic leukemia on hypomethylating agents: a computational perspective
Authors: Hein Than, Yi Qiao, Xiaomeng Huang, Dongqing Yan, Jamshid S. Khorashad, Anthony D. Pomicter, Tibor J. Kovacsovics, Gabor T. Marth, Thomas O’Hare, Michael W. Deininger
Journal: Leukemia (2018)
TRANSORAL OUTLET REDUCTION (TORE) COMBINED WITH ENDOSCOPIC SLEEVE GASTROPLASTY (ESG) FOR WEIGHT REGAIN AFTER GASTRIC BYPASS
Authors: V Bove, I Boškoski, R Landi, A Tringali, P Familiari, V Perri, G Costamagna
Journal: Endoscopy (2018)

Gastrojejunal anastomosis enlargement is associated with weight regain in patients with Roux-en-Y gastric bypass (RYGB). Endoscopic transoral outlet reduction (TORe) has been proven as safe and effective for treatment of weight regain due to anastomosis enlargement after RYGB.
Association of Author Gender With Sex Bias in Surgical Research
Authors: Nicholas Xiao, Neel A. Mansukhani, Diego F. Mendes de Oliveira, Melina R. Kibbe
Journal: JAMA Surgery (2018)

Previous studies demonstrate sex bias in surgical research. Female participants and investigators are underrepresented in surgical scientific research. To describe the distribution of male and female authors in 5 general-interest surgery journals, assess the association of author gender with sex bias, and explore whether investigators benefit from performing sex-inclusion research. For this bibliometric analysis, data were abstracted from 1921 original, peer-reviewed articles published from January 1, 2011, through December 31, 2012, in Annals of Surgery, American Journal of Surgery, JAMA Surgery, The Journal of Surgical Research, and Surgery. Excluded articles pertained to a sex-specific disease or did not report the number of study participants. An additional 119 articles contained gender-ambiguous author names and were omitted. Data were analyzed from April to June 2017. Male and female first and senior authors, number of female and male participants in each study, surgical specialty, and number of citations received per article. Of the 3604 authors of 1802 articles included in this study, 2791 first and senior authors (77.4%) were male and 813 (22.6%) were female. The prevalence of male and female authors was consistent across all 5 journals and among clinical and basic science research. Articles by female authors included a higher median number of female study participants compared with their male counterparts (27.5 vs 16.0; P = .01), but sex matched the inclusion of participants less frequently (36% vs 45%; P = .001). No sex-based differences occurred between male and female authors in reporting, statistical analysis, and discussion of the data or in the number of citations received. Compared with studies that did not report, analyze, or discuss data by sex, studies that performed sex-specific data reporting yielded a mean of 2.8 more citations (95% CI, 1.2-4.4; P = .001); those that performed statistical analysis, a mean of 3.5 more citations (95% CI, 1.8-5.1; P = .001); and those that discussed the data, a mean of 2.6 more citations (95% CI, 0.7-4.5; P = .001). Articles with a higher percentage of sex matching of participants also received more citations, with an increase of 1 citation per 4.8% (95% CI, 2.0%-7.7%; P = .001) increase in percentage of sex matching. Sex bias in surgical research is prevalent among male and female authors; however, female authors included proportionally more female participants in their studies compared with male authors. Notably, studies that addressed sex bias were rewarded by the scientific community with increased citations of their published work.
What does agency afford the self?
Authors: Bradley Franks, Benjamin G Voyer
Journal: Behavioral and Brain Sciences (2018)

Abstract We welcome Doris's dual systems, social account of agency and self. However, we suggest that a level of affordances regarding agency is interpolated between those dual systems. We also suggest a need to consider joint (“we”) agency in addition to individual (“I”) agency, and we suggest a more fundamental role for culture in configuring both the values entering the dialogue that generates the sense of agency and self, and the nature of the dialogue itself.
Quarter of childhood asthma cases in Bradford are linked to traffic pollution
Authors: Ingrid Torjesen
Journal: BMJ (2018)

Air pollution may be responsible for more than a third of childhood asthma cases in the UK city of Bradford and a quarter may be due to traffic pollution alone, a study has found.1

An international group of researchers used a newly developed method that knits together four assessment models—traffic, emissions, atmospheric dispersion, and health impact—to assess the effect of exposure to nitrogen oxides on the development of childhood asthma.

These models allowed the team to chart …
Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis
Authors: Pilar Mur, Richarda M. De Voer, Rubén Olivera-Salguero, Sandra Rodríguez-Perales, Tirso Pons, Fernando Setién, Gemma Aiza, Rafael Valdés-Mas, Angelo Bertini, Marta Pineda, Lilian Vreede, Matilde Navarro, Silvia Iglesias, Sara González, Joan Brunet, Alfonso Valencia, Manel Esteller, Conxi Lázaro, Geert J. P. L. Kops, Miguel Urioste, Xose S. Puente, Gabriel Capellá, Laura Valle
Journal: Molecular Cancer (2018)

Germline mutations in BUB1 and BUB3 have been reported to increase the risk of developing colorectal cancer (CRC) at young age, in presence of variegated aneuploidy and reminiscent dysmorphic traits of mosaic variegated aneuploidy syndrome. We performed a mutational analysis of BUB1 and BUB3 in 456 uncharacterized mismatch repair-proficient hereditary non-polyposis CRC families and 88 polyposis cases. Four novel or rare germline variants, one splice-site and three missense, were identified in four families. Neither variegated aneuploidy nor dysmorphic traits were observed in carriers. Evident functional effects in the heterozygous form were observed for c.1965-1G>A, but not for c.2296G>A (p.E766K), in spite of the positive co-segregation in the family. BUB1 c.2473C>T (p.P825S) and BUB3 c.77C>T (p.T26I) remained as variants of uncertain significance. As of today, the rarity of functionally relevant mutations identified in familial and/or early onset series does not support the inclusion of BUB1 and BUB3 testing in routine genetic diagnostics of familial CRC.