tbuckley/cabot-search huggingface dataset:
Immunotherapy Leads to Complete Regression in Late-Stage Breast Cancer
Authors: Jennifer Abbasi
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sección endoscópica de prótesis biliares plásticas y metálicas: Una técnica accesoria de la CPRE útil y segura en casos seleccionados
Authors: N Mora Cuadrado, AY Carbajo López, M De Benito Sanz, ST Law, S Sevilla Ribota, R Sánchez-Ocaña Hernández, I Peñas Herrero, P Gil Simón, C De La Serna Higuera, M Pérez-Miranda Castillo
Journal: Endoscopy (2017)

la sección endoscópica de prótesis biliares metálicas con argón es una técnica útil en casos de migración o malposición. No se han descrito técnicas para la sección endoscópica de prótesis plásticas. Se desconoce si ello es viable, su potencial eficacia y seguridad.
Abstract 15617: Liver X Receptor {alpha} is essential for myocardial fatty acid and glucose metabolism
Authors: Teayoun Kim, Sijie Wu, Jiwen Luo, Peiyong Wang, Jian Liu, Zhelyabovska Olga, Qinglin Yang
Journal: Circulation (2011)

Liver X receptors (α and β) are nuclear receptors and ligand-dependent transcription factors. LXRs have been recognized as key transcriptional regulators of lipid and glucose metabolism, as well as...
Gordon Francis Falconer
Authors: Daniel Falconer, Aimee Lucas
Journal: BMJ (2018)

Gordon Francis Falconer was the oldest of fiven children born to Dr Eric Falconer and Margaret Falconer. He trained in London at Guy’s Hospital and became a house officer in orthopaedics in 1965, before moving to Royal Surrey County Hospital, Guildford, in the same role, in 1966. In 1967 he became senior house officer in paediatrics at St Luke’s Hospital in Guildford. Subsequently he was SHO in general surgery-urology and a year later in obstetrics and gynaecology.

In 1969 he became registrar in obstetrics and gynaecology, still at St Luke’s Hospital. In 1971 he moved to Manchester and took the same role at St Mary’s …
Subjective Cognitive Decline Among Adults Aged ≥45 Years — United States, 2015–2016
Authors: Christopher A. Taylor, Erin D. Bouldin, Lisa C. McGuire
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Subjective cognitive decline (SCD) is the self-reported experience of worsening or more frequent confusion or memory loss within the previous 12 months (1,2) and one of the earliest noticeable symptoms of Alzheimer's disease (Alzheimer's), a fatal form of dementia (i.e., a decline in mental abilities severe enough to interfere with everyday life) (1). Alzheimer's is the most common form of dementia, although not all memory loss results from Alzheimer's (3). To examine SCD, CDC analyzed combined data from the 2015 and 2016 Behavioral Risk Factor Surveillance System (BRFSS) surveys. Overall, 11.2% of adults aged ≥45 years reported having SCD, 50.6% of whom reported SCD-related functional limitations. Among persons living alone aged ≥45 years, 13.8% reported SCD; among persons with any chronic disease, 15.2% reported SCD. Adults should discuss confusion or memory loss with a health care professional who can assess cognitive decline and address possible treatments and issues related to chronic disease management, medical care, and caregiving.
Prótesis como puente a la cirugía frente a cirugía primaria. Recurrencia oncológica en pacientes con obstrucción maligna de colon izquierdo
Authors: C Lara Romero, I Lavín Castejón, A García, E Romero, A García, G Alcaín Martínez
Journal: Endoscopy (2017)

Las prótesis colónicas como puente a la cirugía permiten resolver la obstrucción y una mayor realización de anastomosis primaria. Diversos estudios plantean dudas sobre la seguridad oncológica.
Screening for Peripheral Artery Disease and Cardiovascular Disease Risk Assessment With the Ankle-Brachial Index
Authors: Susan J. Curry, Alex H. Krist, Douglas K. Owens, Michael J. Barry, Aaron B. Caughey, Karina W. Davidson, Chyke A. Doubeni, John W. Epling, Alex R. Kemper, Martha Kubik, C. Seth Landefeld, Carol M. Mangione, Michael Silverstein, Melissa A. Simon, Chien-Wen Tseng, John B. Wong
Journal: JAMA (2018)

Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the lower limbs. It can impair walking and, in severe cases, can lead to tissue loss, infection, and amputation. In addition to morbidity directly caused by PAD, patients with PAD are at increased risk for cardiovascular disease (CVD) events, because atherosclerosis is a systemic disease that also causes coronary and cerebrovascular events.To update the 2013 US Preventive Services Task Force (USPSTF) recommendation on screening for PAD and CVD risk with the ankle-brachial index (ABI).The USPSTF reviewed the evidence on whether screening for PAD with the ABI in generally asymptomatic adults reduces morbidity or mortality from PAD or CVD. The current review expanded on the previous review to include individuals with diabetes and interventions that include supervised exercise and physical therapy intended to improve outcomes in the lower limbs.The USPSTF found few data on the accuracy of the ABI for identifying asymptomatic persons who can benefit from treatment of PAD or CVD. There are few studies addressing the benefits of treating screen-detected patients with PAD; 2 good-quality studies showed no benefit of using the ABI to manage daily aspirin therapy in unselected populations, and 2 studies showed no benefit from exercise therapy. No studies addressed the harms of screening, although the potential exists for overdiagnosis, labeling, and opportunity costs. Studies that addressed the harms of treatment showed nonsignificant results. Therefore, the USPSTF concludes that the current evidence is insufficient and that the balance of benefits and harms of screening for PAD with the ABI in asymptomatic adults cannot be determined.The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for PAD and CVD risk with the ABI in asymptomatic adults. (I statement).
POEM, un tratamiento seguro y eficaz en los trastornos motores esofágicos no-acalásicos. Estudio multicéntrico internacional
Authors: E Albéniz, A Elosua, F Estremera, R Iglesias, I Aresté, JJ Vila, G Costamagna, J Devière, YI Chen, M Khashab
Journal: Endoscopy (2017)

La eficacia de la miotomía peroral endoscópica (POEM) en los trastornos motores esofágicos no acalásicos (obstrucción funcional del esfínter esofágico inferior (EGJOO), espasmo del esófago distal (DES) y el esófago hipercontráctil o Jackhammer (JE) no ha sido demostrada, existiendo únicamente algunas pequeñas series de casos.
Whole of community pain education for back pain. Why does first-line care get almost no attention and what exactly are we waiting for?
Authors: G Lorimer Moseley
Journal: British Journal of Sports Medicine (2018)

A recent series of back pain articles in The Lancet 1–3 attracted a great deal of attention across the media, with the usual outrage at physios and doctors providing useless treatments, and the usual advice to sufferers to exercise and get psychological help. The authors—some of the most prolific back pain researchers on the planet—made a ‘call to action’ and it was a sensible one. But it was not really a new one—we have known for decades not to ‘ take back pain lying down ,’4 that the vast majority of back pain episodes do not require surgery or long-term powerful analgesics, and that most will resolve over time if we do not mess them up. So how is it that we are still in this mire of spiralling costs and widespread disability? When are we going to stop taking the very solid science and sensible calls to action just to see it mashed into an accusatory swing at doctors to clean up their act or sufferers to ‘get over it, change their mindset and exercise’?

Back pain is not a simple problem. There are many forces at play 5 that propagate its widespread mismanagement. The massive elephant in the room—that entire professions appear to depend on the problem remaining unsolved—will be hard to tackle. In the meantime, the glaringly obvious cornerstone of best practice care that somehow keeps flying under the radar is education.

Education is universally recommended as first-line treatment for acute and persistent back pain but it attracts little attention. Indeed, The Lancet papers1–3 clearly listed education of …
INITIATION OF QUALITY ASSURANCE PROGRAM REDUCED ERCP COMPLICATION RATES IN HIGH VOLUME CENTER
Authors: T Gyökeres, Á Orbán-Szilágyi, K Lőrinczy, L Vatai, K Rábai, M Horváth, F Zsigmond
Journal: Endoscopy (2018)

We prospectively collected data between April 2016-April 2017 about cannulation success and complication rates as widely accepted quality indicators of ERCP. As majority of ERCP complications occur in patients with naive papilla and cannulation rate is most reliable in this settings as well, we considered only patients with naive papilla. After evaluation of these quality parameters an action plan was carried out. After implementation of determined changes the same data were collected during the next 6 months.
Cluster Headache and Calcitonin Gene-Related Peptide—More on Quantum Therapeutics in Headache Medicine
Authors: Amy A. Gelfand, Peter J. Goadsby
Journal: JAMA Neurology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Enhanced immigration enforcement in the USA and the transnational continuity of HIV care for Latin American immigrants in deportation proceedings
Authors: Kathleen R Page, Suzanne Dolwick Grieb, Karen Nieves-Lugo, Thespina Yamanis, Holly Taylor, Omar Martinez, Yoshiaki Yamasaki, Rupali Limaye, Wendy Davis, Chris Beyrer, María Cecilia Zea
Journal: The Lancet HIV (2018)
Advancing the public health applications of Chlamydia trachomatis serology
Authors: Sarah C Woodhall, Rachel J Gorwitz, Stephanie J Migchelsen, Sami L Gottlieb, Patrick J Horner, William M Geisler, Catherine Winstanley, Katrin Hufnagel, Tim Waterboer, Diana L Martin, Wilhelmina M Huston, Charlotte A Gaydos, Carolyn Deal, Magnus Unemo, J Kevin Dunbar, Kyle Bernstein
Journal: The Lancet Infectious Diseases (2018)
Polylactide-tethered prodrugs in polymeric nanoparticles as reliable nanomedicines for the efficient eradication of patient-derived hepatocellular carcinoma
Authors: Hangxiang Wang, Liqian Zhou, Ke Xie, Jiaping Wu, Penghong Song, Haiyang Xie, Lin Zhou, Jialin Liu, Xiao Xu, Youqing Shen, Shusen Zheng
Journal: Theranostics (2018)

Nanomedicines have been extensively explored for cancer treatment, and their efficacies have arguably been proven in various cancer cell-derived xenograft (CDX) mouse models. However, they generally fail to show such therapeutic advantages in patients because of the huge pathological differences between human tumors and CDX models. Methods: In this study, we fabricated colloidal ultrastable nanomedicines from polymeric prodrugs and compared the therapeutic efficacies in hepatocellular carcinoma (HCC) CDX and clinically relevant patient-derived xenograft (PDX) mouse models, which closely mimic human tumor pathological properties. Working towards this goal, we esterified a highly potent SN38 (7-ethyl-10-hydroxycamptothecin) agent using oligo- or polylactide (oLA or PLA) segments with varying molecular weights. Results: The resulting SN38 conjugates assembled with polyethylene glycol-block-polylactic acid to form systemically injectable nanomedicines. With increasing PLA chain length, the SN38 conjugates showed extended retention in the nanoparticles and superior antitumor activity, completely eradicating xenografted tumors in both mouse models. Our data implicate that these small-sized and ultrastable nanomedicines might also efficaciously treat cancer in patients. More interestingly, the systemically delivered nanomedicines notably alleviated the incidence of bloody diarrhea. Conclusion: Our studies demonstrate that the appropriate molecular editing of anticancer drugs enables the generation of better tolerated cytotoxic nanotherapy for cancer, which represents a potentially useful scaffold for further clinical translation.
Long-acting Reversible Contraception—Highly Efficacious, Safe, and Underutilized
Authors: Justine P. Wu, Michelle H. Moniz, Allison N. Ursu
Journal: JAMA (2018)

This JAMA Clinical Update reviews the features of commercially available intrauterine devices (IUDs) and progestin implants, misunderstanding about their safety, noncontraceptive benefits, and how to select the form of long-acting reversible contraception (LARC) best for an individual patient.
Abstract 19851: Impact of Neutrophils to Lymphocytes Ratio in Acute Coronary Syndromes: A Meta-analysis of Major Clinical Outcomes
Authors: Francesco Dentali, Olga Nigro, Alessandro Squizzato, Anna M Grandi, Luigina Guasti
Journal: Circulation (2017)

Introduction: The ratio between neutrophils and lymphocytes (NLR) is a potential new biomarker, which can single out individuals at risk for future cardiovascular (CV) events. Among total white blo...
Migración de las prótesis de aposición luminal tipo Axios. Riesgo acumulado y factores determinantes
Authors: FJ García-Alonso, I Peñas-Herrero, R Sánchez-Ocaña, S Sevilla-Ribota, M De Benito Sanz, M Cimavilla, AY Carbajo López, P Gil-Simón, C De La Serna-Higuera, M Pérez-Miranda
Journal: Endoscopy (2017)

Las prótesis de aposición luminal (PAL) permiten crear anastomosis endoscópicamente, siendo una opción atractiva si el riesgo quirúrgico es alto. Existe incertidumbre sobre su comportamiento a largo plazo.
MUCOSAL FLATTENING ASSISTED COLONOSCOPY (FAC) TO IMPROVE THE ADENOMA DETECTION RATE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: C Marmo, V Napolitano, L Fei, C Hassan, R Marmo
Journal: Endoscopy (2018)

Improving ADR is the central focus of the current quality movement in colonoscopy. The fold flattening devices could ameliorate the ADR.
Content validity of video recorded consultations needs to be proved
Authors: T. Coleman, T. Manku-Scott, A. Howe
Journal: BMJ (1996)

Content validity of video recorded consultations needs to be proved EDrroR,-Douglas Carnall voices his doubts about the introduction of summative assessment for registrars in general practice.'We are concerned about the use of video recordings of consultations with patients in one component of the assessment.Although one team of researchers has shown the reliability of its method of video recorded assessment (that is, that repeating the exercise produces consistent results),2 no one has shown that assessment with video recording has content validity.3To show content validity, assessors would need to show that consultations video recorded for assessment purposes were not vastly different from others.Unfortunately, our experience of using video recorded consultations for research purposes suggests that this is unlikely to be so.In two separate research projects, patients' consent to video recording was sought in accordance with recent guidelines.4We independently investigated the factors associated with patients withholding consent to recording.In both analyses the demographic characteristics ofpatients who agreed to recording seemed to be significantly different from those of patients who withheld consent.Additionally, one study has shown significant differences in the clinical problems presented in each of these two groups.'We cannot present our detailed conclusions here because we are preparing papers for publication.We believe, however, that the assessors of registrars in general practice will need to give our findings close scrutiny.The onus is likely to fall on them to prove that the differences we have highlighted are not present when patients' consent to video recording is sought for assessment purposes.
Ingesta de cáusticos. Experiencia en el hospital son Llàtzer (Palma de Mallorca)
Authors: G Thomás Salom, C De Zárraga Mata, Á Brotons García, A Vilella Martorell, ÁL Maura Oliver, A Puy Guillén, C Dolz Abadía
Journal: Endoscopy (2017)

La ingesta de cáusticos constituye una causa frecuente de gastroscopia urgente. La relevancia de estas lesiones radica además de en su frecuencia en su importante morbimortalidad asociada. Algunos pacientes pueden requerir seguimiento endoscópico.
Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC
Authors: Natsuko Tokonami, Tomoaki Takata, Jan Beyeler, Iris Ehrbar, Ayumi Yoshifuji, Erik I. Christensen, Johannes Loffing, Olivier Devuyst, Eric G. Olinger
Journal: Kidney International (2018)

Uromodulin, the most abundant protein in normal urine, is essentially produced by the cells lining the thick ascending limb. There it regulates the activity of the cotransporter NKCC2 and is involved in sodium chloride handling and blood pressure regulation. Conflicting reports suggested that uromodulin may also be expressed in the distal convoluted tubule (DCT) where its role remains unknown. Using microdissection studies combined with fluorescent in situ hybridization and co-immunostaining analyses, we found a significant expression of uromodulin in mouse and human DCT at approximately 10% of thick ascending limb expression levels, but restricted to the early part of the DCT (DCT1). Genetic deletion of Umod in mouse was reflected by a major shift in NCC activity from the DCT1 to the downstream DCT2 segment, paralleled by a compensatory expansion of DCT2. By increasing the distal sodium chloride and calcium ion load with chronic furosemide administration, an intrinsic compensatory defect in the DCT from Umod-/- compared to wild type mice was found manifested as sodium wasting and hypercalciuria. In line, co-expression studies in HEK cells suggested a facilitating role for uromodulin in NCC phosphorylation, possibly via SPAK-OSR1 modulation. These experiments demonstrate a significant expression of uromodulin in the early part of mouse and human DCT. Thus, biosynthesis of uromodulin in the DCT1 is critical for its function, structure and plasticity, suggesting novel links between uromodulin, blood pressure control and risk of kidney stones.Graphical abstract
Abstract 18317: An Interactive Online Education Program Improves Knowledge of ECG Monitoring: Findings From the PULSE Trial
Authors: Marjorie Funk, Jeanine L May, Kimberly Stephens, Kristopher P Fennie, Pei-Shiun Chang, Catherine Winkler, Shelli L Feder, Barbara J Drew
Journal: Circulation (2013)

Introduction: Evidence suggests that ECG monitoring practices are inconsistent and inadequate, which may be due to knowledge deficits of nurses. We evaluated whether an interactive online education program improves knowledge related to ECG monitoring. Methods: The PULSE Trial is a 5-year multi-site randomized clinical trial with crossover to evaluate the effect of implementing the AHA practice standards for ECG monitoring on nurses’ knowledge, quality of care, and patient outcomes. We report data related to nurses’ knowledge from all 3 phases. The sample included nurses on cardiac units in 14 hospitals. After nurses completed a validated 20-item knowledge test, hospitals were randomized to the experimental or control group. Experimental group nurses completed the education program that covered essentials of ECG monitoring and arrhythmia, ischemia, and QT interval monitoring. They then re-took the knowledge test. In phase 3, 12-18 months later, experimental group nurses re-took the test to evaluate knowledge retention and control group nurses took the education program and test. We used mixed modeling to address repeated measures and hospital intra-correlation. Results: The sample contained 2,560 unique nurses (90% female, 75% white, mean age 38±11 years). Mean test scores improved (p&lt;.0001) in both groups (71.2) immediately after the intervention, but declined to 61.1 12-18 months later in the experimental group. This was lower (p&lt;.0001) than right after the intervention, but higher (p&lt;.0001) than before. Of the 4 subsections of the test, essentials of ECG monitoring had the highest mean post-test scores (77) and ischemia monitoring had the lowest (56). The pattern of change for all subsections was similar to the entire test. Conclusions: Although test scores improved after the education, gains diminished over time, but were better than at baseline. Whether the improved knowledge translates into better quality of care and patient outcomes will be determined.