tbuckley/cabot-search huggingface dataset:
Quality of life evaluation in lymphoedema
Authors: M. Augustin, E. Conde Montero, K. Hagenström, K. Herberger, C. Blome
Journal: British Journal of Dermatology (2018)

The lymphatic system is a network of small vessels draining clear fluid (lymph) from all bodily tissues. Many different disorders, including birth defect, infection and malignancy (cancer), can cause blockage of the system, resulting in chronic swelling, usually affecting arms or legs. This “lymphoedema” causes considerable discomfort and affects many aspects of the patient's life. Health‐related quality of life (QOL) is an important measure in health care, but to date the only QOL measure for patients with lymphoedema has been the Freiburg Life Quality Assessment for lymphoedema (FLQA‐L) ‐ a reliable measure but just too detailed for regular use in clinical practice, having 92 questions. This study from Germany aimed to create a more user‐friendly version. First, they re‐analysed the original FLQA‐L data and identified 33 questions which appeared most informative, covering 5 domains: physical impairments, daily life, social life, mental health and therapy. This shorter version (FLQA‐LS) was then mailed out to 348 lymphoedema patients at 33 clinics; 91% were women and the average age was 57 years. 295 patients completed the questionnaire. The items scoring highest (meaning having the highest impact) were “anxiety about a possible worsening of the disease”, “feeling pain in the arm or leg”, “joint pain” and “time‐consuming treatments”, while impairment of social life showed the lowest values. Statistical analysis of the results showed good correlations with other general health related QOL scores. The FLQA‐LS appears to be a valuable assessment tool for patients with lymphoedema and now needs to be tested in patients over time.
Aphasic Binary Reversals in Patients With Neurological Disease as a Barrier to Clinical Decision Making
Authors: Harri Sivasathiaseelan, Charles R. Marshall, Chris J. D. Hardy, Nick C. Fox, Jason D. Warren, Martin N. Rossor
Journal: JAMA Neurology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Sleep disturbance in psoriasis
Authors: P. Jensen, C. Zachariae, L. Skov, R. Zachariae
Journal: British Journal of Dermatology (2018)

Psoriasis is a common skin disease that affects 4‐5% of people worldwide. Psoriasis can be recognized by red, scaly areas on the skin, most often on the elbows, knees, scalp, and lower back. Given these physical symptoms, one could suspect that people with psoriasis may have difficulty sleeping. This study from Copenhagen, Denmark aimed to examine sleep disturbance in psoriasis. The study included 179 patients with psoriasis and 105 people without psoriasis, who all completed questionnaires on sleep quality. Twenty‐five per cent of the patients with psoriasis had difficulty sleeping and over half of them could be classified as poor sleepers. These numbers were much higher than what was what found in the people without psoriasis. Also, the authors found out that itchy skin was the main explanation for the reduced sleep quality in patients with psoriasis.
Physician attire and palliative care patients’ perception of physician compassion and professionalism: A randomized controlled trial (RCT).
Authors: Ahsan Azhar, Kimberson Cochien Tanco, Ali Haider, Hilda P. Cantu, Carolina Diaz Hernandez, Petra A Rantanen, Minjeong Park, Diane D. Liu, Janet L. Williams, Eduardo Bruera
Journal: Journal of Clinical Oncology (2018)

39 Background: Environment is important component of communication skills. Physicians’ communication style including attire may influence patient perceptions. Previous studies mostly based on pictures of providers in different attires provide conflicting evidence. This RCT aimed to explore the effects of physician attire on patients’ perceptions of compassion, professionalism and physician preference. Hypothesis was that patients will perceive the doctor in formal attire as more compassionate than the doctor wearing casual attire. Methods: 105 English speaking adult follow-ups at outpatient supportive care center, were randomized to watch 2 standardized, 3-minute video vignettes, with similar script, depicting a routine clinic encounter. In one video, physician was wearing formal attire with tie and buttoned up white coat, while in the other, physician was in casual attire without a tie or white coat. Actors and patients were all blinded to purpose of the study. Investigators were blinded to the videos watched by patients. After viewing each video, patients completed validated questionnaires rating their perception of physician compassion (0 = best, 50 = worst) and professionalism (5 = poor, 25 = very good). Patients were also asked to rate their preference for the physician. Results: There were no significant differences between formal and casual attire for compassion [median (IQR), 25 (10, 31) vs 20 (8, 27); P = 0.31] and professionalism, [17 (13, 21) vs 18 (14, 22); P = 0.42]. 32 (30%) patients preferred formal, 33 (31%) preferred casual attire and 40 (38 %) patients had no preference. Subgroup analysis did not show significant differences among age, sex, marital status and education level for compassion, professionalism and physician preference. Conclusions: Doctor’s attire did not have an effect on patients’ perception of physicians’ level of compassion and professionalism. Dress code also did not influence the patients’ preference for their doctor or their trust and confidence in the doctor’s ability to provide care. There is need for more RCTs in area of communication skills specifically to better understand the impact of different attires on patient perceptions. Clinical trial information: NCT03168763.
Gold Nanoparticles with Antibiotic‐Metallopolymers toward Broad‐Spectrum Antibacterial Effects
Authors: Peng Yang, Parasmani Pageni, Md Anisur Rahman, Marpe Bam, Tianyu Zhu, Yung Pin Chen, Mitzi Nagarkatti, Alan W. Decho, Chuanbing Tang
Journal: Advanced Healthcare Materials (2018)

Bacterial infection has evolved into one of the most dangerous global health crises. Designing potent antimicrobial agents that can combat drug-resistant bacteria is essential for treating bacterial infections. In this paper, a strategy to graft metallopolymer-antibiotic bioconjugates on gold nanoparticles is developed as an antibacterial agent to fight against different bacterial strains. Thus, these nanoparticle conjugates combine various components in one system to display enhanced bactericidal efficacy, in which small sized nanoparticles provide high surface area for bacteria to contact, cationic metallopolymers interact with the negatively charged bacterial membranes, and the β-lactam antibiotics' sterilzation capabilities are improved via evading intracellular enzymolysis by β-lactamase. This nanoparticle-based antibiotic-metallopolymer system exhibits an excellent broad-spectrum antibacterial effect, particularly for Gram-negative bacteria, due to the synergistic effect of multicomponents on the interaction with bacteria.
Prognostic Testing and Treatment Approaches in Patients with Chronic Lymphocytic Leukemia: Clinical Experience from an Interim Analysis of the informCLLTM Real-World Registry
Authors: Anthony R. Mato, Jacqueline C. Barrientos, Danielle M. Brander, John M. Pagel, Meghan Gutierrez, Karen Kadish, Brian Tomlinson, Nilanjan Ghosh, Nick Giafis, David Ipe, Sandhya Upasani, Murali Sundaram, Lucille Ferrante, Carlos Amaya-Chanaga, Reethi Iyengar, Jeff Sharman
Journal: Blood (2018)
The Influence of Physicochemical Properties of Biomimetic Hydroxyapatite on the In Vitro Behavior of Endothelial Progenitor Cells and Their Interaction with Mesenchymal Stem Cells
Authors: Joanna Maria Sadowska, Jordi Guillem‐Marti, Maria‐Pau Ginebra
Journal: Advanced Healthcare Materials (2018)

Calcium phosphate (CaP) substrates are successfully used as bone grafts due to their osteogenic properties. However, the influence of the physicochemical features of CaPs in angiogenesis is frequently neglected despite it being a crucial process for bone regeneration. The present work focuses on analyzing the effects of textural parameters of biomimetic calcium deficient hydroxyapatite (CDHA) and sintered beta-tricalcium phosphate (β-TCP), such as specific surface area, surface roughness, and microstructure, on the behavior of rat endothelial progenitor cells (rEPCs) and their crosstalk with rat mesenchymal stem cells (rMSCs). The higher reactivity of CDHA results in low proliferation rates in monocultured and cocultured systems. This effect is especially pronounced for rMSCs alone, and for CDHA with a fine microstructure. In terms of angiogenic and osteogenic gene expressions, the upregulation of particular genes is especially enhanced for needle-like CDHA compared to plate-like CDHA and β-TCP, suggesting the importance not only of the chemistry of the substrate, but also of its textural features. Moreover, the coculture of rEPCs and rMSCs on needle-like CDHA results in early upregulation of osteogenic modulator, i.e., protein deglycase 1 might be a possible cause of overexpression of osteogenic-related genes on the same substrate.
Biomedical Applications of Layer‐by‐Layer Self‐Assembly for Cell Encapsulation: Current Status and Future Perspectives
Authors: Tengfei Liu, Ying Wang, Wen Zhong, Bingyun Li, Kibret Mequanint, Gaoxing Luo, Malcolm Xing
Journal: Advanced Healthcare Materials (2018)

Abstract Encapsulating living cells within multilayer functional shells is a crucial extension of cellular functions and a further development of cell surface engineering. In the last decade, cell encapsulation has been widely utilized in many cutting‐edge biomedical fields. Compared with other techniques for cell encapsulation, layer‐by‐layer (LbL) self‐assembly technology, due to the versatility and tunability to fabricate diverse multilayer shells with controllable compositions and structures, is considered as a promising approach for cell encapsulation. This review summarizes the state‐of‐the‐art and potential future biomedical applications of LbL cell encapsulation. First of all, a brief introduction to the LbL self‐assembly technique, including assembly mechanisms and technologies, is made. Next, different cell encapsulation strategies by LbL self‐assembly techniques are explained. Then, the biomedical applications of LbL cell encapsulation in cell‐based biosensors, cell transplantation, cell/molecule delivery, and tissue engineering, are highlighted. Finally, discussions on the current limitations and future perspectives of LbL cell encapsulation are also provided.
The pyramid of treatment levels: A tool to convey goal-based treatment options.
Authors: Heather Leeper, Andrew Kamell
Journal: Journal of Clinical Oncology (2018)

147 Background: 60% of Americans die in acute care hospitals and under 40% of advanced cancer patients have end-of-life care discussions with their health care providers. Didactic methods and tools to teach about symptom management, navigation of treatment decisions, code status, and end-of-life care decisions within an inpatient setting are a necessity to meet this high demand. Methods: A model of medical care systematically dividing clinical management decisions into escalating levels of medical care relative to illness severity, treatment goals, and code status was created. The model is illustrated as a pyramid with a base of symptom management as the initial level of medical care. The second level represents disease-focused medical care including antibiotics, disease-modifying drugs, and chemotherapy administration. Hospitalization with increasingly complex and invasive interventions represents the third level followed by critical illness care including ICU admission and vasopressors as the fourth level. Intubation comprises the fifth level and CPR forms the top of the pyramid. Results: This model has been used extensively at our institution in educating medical students, residents, fellows, and faculty. All groups reported it was helpful in understanding POLST forms, code status, and collaboratively developing appropriate goal-based care plans with their patients. Symptom management remaining as a non-negotiable foundation of care emphasizes its importance. This depiction of medical care may facilitate goals of care and code status discussions and is particularly helpful for determining appropriate care goals or options when considering de-escalation of medical therapies. Used implicitly or explicitly in patient and family discussions, it has facilitated decision-making and discerning the appropriateness of the overall treatment plan relative to patient goals of care. Conclusions: This model of care with its companion pyramid accommodate a wide range of clinical scenarios, is an effective, high yield didactic device for patients, families, and healthcare providers alike, and has applications as supportive tool to optimize goal-based clinical decision making in the context of serious illness.
SAT0681 The causal association between childhood and adulthood body mass index and osteoarthritis: a mendelian randomizationstudy
Authors: A. Prats-Uribe, S. Sayols-Baixeras, A. Fernández-Sanlés, T. Duarte-Salles, J. Logue, R. Elosua, D. Prieto-Alhambra
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Childhood obesity is a strong predictor of adult obesity. Body mass index (BMI) has been associated with a dose-response increase in risk of osteoarthritis. However, studying causality in this association is difficult due to confounding factors <h3>Objectives</h3> To study the causal association of childhood and adult BMI on the risk of developing osteoarthritis using Mendelian Randomization (MR) methods <h3>Methods</h3> A two-step MR analysis was conducted. Exposures were determined by reviewing data from two genome-wide association study (GWAS) from &gt;47,000 children describing 15 SNPs associated with childhood BMI, and another GWAS describing 97 SNPs related to BMI within 3 39 224 adults. For the outcomes, data gathered from a GWAS analysing 3 37 000 unrelated individuals in the UK BioBank was used to assess the association between the SNPs of interest and self-reported osteoarthritis and ICD10 linked hospital data: knee, hip and first carpo-metacarpal joint osteoarthritis. Traumatic eye injury from the same cohort was used as a negative control. An inverse variance weighted meta-analysis estimator was used to test for association. In presence of heterogeneity, a weighted median approach was used and, when necessary, pleiotropy was controlled for using the MR Egger method. All analyses were performed using the TwoSampleMR package in R <h3>Results</h3> 14 and 91 SNPs associated with BMI in the childhood and adulthood were identified in the UK BioBank GWAS respectively. Association between childhood BMI and adult OA was seen for self-reported and hip and knee OA. Adult BMI also appeared associated with them [figure 1]. Conversely, no associations were found between BMI (either childhood or adult) and Hand OA risk. Finally, no relationship was seen between BMI and traumatic eye injury (negative control) <h3>Conclusions</h3> Higher BMI in both childhood and adulthood overweight/obesity cause an excess in risk of knee and hip osteoarthritis. Whilst the effect of adult BMI seems stronger on knees, childhood BMI might impact both knee and hip osteoarthritis risk similarly. Age-specific associations should be treated with caution given significant overlap between loci associated with BMI across age ranges. In contrast, our findings contradict previous cohorts that found an association between overweight/obesity and hand osteoarthritis, which could be explained by confounding factors such as manual work or related socio-economic factors. The association between increased BMI and knee or hip osteoarthritis adds further impetus to strategies for the prevention of childhood and adult obesity in order to reduce subsequent disability. <h3>Disclosure of Interest</h3> None declared
Electroanatomic and Pathologic Right Ventricular Outflow Tract Abnormalities in Patients With Brugada Syndrome
Authors: Maurizio Pieroni, Pasquale Notarstefano, Antonio Oliva, Oscar Campuzano, Pasquale Santangeli, Monica Coll, Martina Nesti, Andrea Carnevali, Aureliano Fraticelli, Anna Iglesias, Simone Grassi, Ramon Brugada, Leonardo Bolognese
Journal: Journal of the American College of Cardiology (2018)
Regional Hyperthermia With Neoadjuvant Chemotherapy for Treatment of Soft Tissue Sarcoma
Authors: Ryan Sun, Lee-Jen Wei
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
PET/CT and MR Features of Infiltrating Spinal Angiolipoma
Authors: Guohua Shen, Minggang Su, Anren Kuang
Journal: Clinical Nuclear Medicine (2018)

Spinal angiolipomas are benign tumors predominantly found in the epidural space. Infiltrating spinal angiolipoma is an extremely rare type, which tends to invade the surrounding tissue and may mimic an aggressive tumor. Herein, we reported the case of a 64-year-old woman with a thoracic angiolipoma involving the T9 vertebral body and its appendix. The lesion showed long T1 and T2 signal intensity on MRI and slightly increased FDG uptake on PET/CT. After surgery, the pathologic examination demonstrated features consistent with angiolipoma, and the patient was free of symptoms.
Strength training to enhance early recovery after hematopoietic stem cell transplantation.
Authors: Eileen Danaher Hacker, Eileen Collins, Chang Park, Tara Peters, Damiano Rondelli
Journal: Journal of Clinical Oncology (2016)

e21687 Background: Intensive cancer treatment followed by hematopoietic stem cell transplantation (HCT) results in moderate to severe fatigue and physical inactivity leading to diminished functional ability. Methods: This study compared strength training to enhance early recovery (STEER) (n = 33) to attentional control with health education (n = 34) in adult HCT patients on primary outcomes (physical activity and fatigue) and secondary outcome (functional ability) in a single-blind randomized clinical trial. Subjects were randomly stratified by type of transplant (allogeneic or autologous) and age (≤ 60 years of age or > 60 years of age). STEER consisted of a comprehensive program of progressive resistance introduced during hospitalization and continued for six weeks following hospital discharge. Attention control with health education subjects received weekly health education post hospitalization. Variables were assessed prior to HCT hospital admission and six weeks following hospital discharge. Using the two-sided alpha level of 0.05, a final sample size of 66 (n = 33 per arm) was planned with 80% statistical power. Data were analyzed using split-plot ANOVAs. Results: Interactions effects were noted for fatigue, p = .04, ηp 2 = .06. The STEER group reported more fatigue at baseline and less fatigue following strength training compared to attention-control. Time, p < .001, ηp 2 = .16, and group effects, p = .05, ηp 2 = .05, were observed for physical activity. Physical activity decreased from baseline to six weeks post hospitalization. The STEER group was more physically active. Group effects were observed for two functional tests (15-foot timed walk, p = .04, ηp 2 = .06; and, timed up and go test, p = .03, ηp 2 = .07. The STEER group completed both tests faster. The timed stair climb, p = .03. ηp 2 = .07, and timed up and go tests, p = .05, ηp 2 = .06, resulted in interaction effects. The STEER group completed both tests faster following completion of strength training. Conclusions: Study findings support the use of strength training to enhance early recovery following HCT with moderate effect sizes. Strength training reduced fatigue while improving physical activity and functional ability six weeks following hospital discharge.