tbuckley/cabot-search huggingface dataset:
Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy
Authors: Serena Pellegatta, Barbara Savoldo, Natalia Di Ianni, Cristina Corbetta, Yuhui Chen, Monica Patané, Chuang Sun, Bianca Pollo, Soldano Ferrone, Francesco DiMeco, Gaetano Finocchiaro, Gianpietro Dotti
Journal: Science Translational Medicine (2018)

The heterogeneous expression of tumor-associated antigens limits the efficacy of chimeric antigen receptor (CAR)-redirected T cells (CAR-Ts) for the treatment of glioblastoma (GBM). We have found that chondroitin sulfate proteoglycan 4 (CSPG4) is highly expressed in 67% of the GBM specimens with limited heterogeneity. CSPG4 is also expressed on primary GBM-derived cells, grown in vitro as neurospheres (GBM-NS), which recapitulate the histopathology and molecular characteristics of primary GBM. CSPG4.CAR-Ts efficiently controlled the growth of GBM-NS in vitro and in vivo upon intracranial tumor inoculation. Moreover, CSPG4.CAR-Ts were also effective against GBM-NS with moderate to low expression of CSPG4. This effect was mediated by the in vivo up-regulation of CSPG4 on tumor cells, induced by tumor necrosis factor-α (TNFα) released by the microglia surrounding the tumor. Overall, the constitutive and TNFα-inducible expression of CSPG4 in GBM may greatly reduce the risk of tumor cell escape observed when targeted antigens are heterogeneously expressed on tumor cells.
“Son” at risk of inheriting of cancer can test DNA of dead man who might be his father
Authors: Clare Dyer
Journal: BMJ (2018)

The High Court can direct a hospital to allow paternity testing using a DNA sample from a person who has died, the Court of Appeal has ruled.1

David Spencer asked the High Court to allow him to be tested against the sample taken from William Anderson, with whom his mother, Carol, had been in a relationship when he was conceived. The pair had split up three months before his birth and his mother’s new partner was registered as his father. Mr Justice Peter Jackson, who granted Spencer’s request, said the application was “apparently unprecedented” in England and Wales.

Anderson …
Prédiction des intervalles de surveillance de coloscopie en temps réel: une étude monocentrique prospective sur 84 patients
Authors: B Brieau, M Barret, S Leblanc, M Dhooge, B Bordacahar, C Leandri, MA Guillaumot, S Ribière, R Coriat, F Prat, S Chaussade
Journal: Endoscopy (2018)

Dans la population générale, la coloscopie de surveillance est réalisée chez les patients ayant des antécédents personnels et/ou familiaux de cancer colo-rectal ou d'adénome, avec des intervalles de temps définis par le résultat de la coloscopie. Cette stratégie doit permettre de réduire l'incidence du cancer d'intervalle, qui correspond à la survenue d'un cancer colorectal avant la date de la coloscopie de surveillance prévue: à l'avenir, la définition de ce délai pourrait être opposable au praticien. Rappelons que selon des données de registre (1), sur 100 coloscopies de dépistage, seulement 3% trouvent un unique polype en dysplasie de haut grade < 10 mm: la reconnaissance de la dysplasie de haut grade pour un unique polype de cette taille fait passer l'intervalle de surveillance de 5 à 3 ans. Dans toutes les autres situations, la connaissance des règles définies par l'HAS (2) font facilement définir l'intervalle de surveillance, immédiatement au décours de la coloscopie. Partant de ce constat, nous avons réalisé une étude afin d'évaluer la capacité de prédiction des intervalles de surveillance de coloscopie dans le cadre du dépistage, chez des gastro-entérologues endoscopistes.
Chronic spontaneous urticaria and autoimmunity: a follow up study of patients with chronic urticaria for 16 years
Authors: Claudia Castilho Mouco, Andressa Zanandréa, João Paulo de Assis, Raisa Borges Castro, Gabriella Melo Fontes Silva Dias, Jorge Kalil, Antonio Abilio Motta, Rosana C. Agondi
Journal: Journal of Allergy and Clinical Immunology (2018)
Correction to: External confirmation and exploration of the Kigali modification for diagnosing moderate or severe ARDS
Authors: Veronica Vercesi, Luigi Pisani, Patricia S. I. van Tongeren, Wim K. Lagrand, Stije J. Leopold, Mischa M. A. Huson, Patricia C. Henwood, Andrew Walden, Marry Smit, Elisabeth D. Riviello, Paolo Pelosi, Arjen M. Dondorp, Marcus J. Schultz
Journal: Intensive Care Medicine (2018)
Reactions to Peanut during a Double-Blind Placebo Controlled Food Challenge (DBPCFC) for Enrolment in a Randomized Trial
Authors: Adriana Chebar Lozinsky, Paxton Loke, Kuang-Chih Hsiao, Christine Axerald, Sigrid Pitkin, Marnie Robinson, EeLyn Su, Anne-Louise Ponsonby, Patrick Quinn, Dean Tey, Michael O'Sullivan, Michael S. Gold, Susan L. Prescott, Katarina Jane Allen, Francesca Orsini, Mimi L.K. Tang
Journal: Journal of Allergy and Clinical Immunology (2018)
The BMJ charity appeal Christmas 2017: help Médecins Sans Frontières help child refugees worldwide
Authors: Richard Hurley
Journal: BMJ (2018)

MSF has decades of experience in bringing medical aid to the neediest people worldwide, included unaccompanied child migrants. As <i>The BMJ</i> draws its appeal to a close for this year, <b>Richard Hurley</b> looks at the often gruesome situation of young migrants, in the Balkans, for example. There’s still time to donate—please give generously
Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions
Authors: Maximilien Evrard, Immanuel W.H. Kwok, Shu Zhen Chong, Karen W.W. Teng, Etienne Becht, Jinmiao Chen, Je Lin Sieow, Hweixian Leong Penny, Goh Chi Ching, Sapna Devi, José Maria Adrover, Jackson L.Y. Li, Ka Hang Liong, Leonard Tan, Zhiyong Poon, Shihui Foo, Jia Wang Chua, I-Hsin Su, Karl Balabanian, Françoise Bachelerie, Subhra K. Biswas, Anis Larbi, William Y.K. Hwang, Vikas Madan, H. Phillip Koeffler, Siew Cheng Wong, Evan W. Newell, Andrés Hidalgo, Florent Ginhoux, Lai Guan Ng
Journal: Immunity (2018)
Incorporating polysomnography into obstructive sleep apnoea phenotyping: moving towards personalised medicine for OSA
Authors: Jean Louis Pépin, Sebastien Bailly, Renaud Tamisier
Journal: Thorax (2018)

Obstructive sleep apnoea (OSA) is a major health concern worldwide with multiorgan consequences and the resulting increased economic and social burden.1 OSA is associated with obesity in more than 60% of cases and often with comorbidities including hypertension, arrhythmia, stroke, coronary heart disease and metabolic dysfunction. The comorbidities are of major importance because they have a significant impact on healthcare use and mortality in patients with OSA. Only half of the patients with OSA are symptomatic and a significant percentage of subjects are referred and treated with the goal of limiting their cardiometabolic risk. This heterogeneity in a highly prevalent chronic disease with millions of patients on home-based long-term treatment requires the complete reshaping of patient characterisation and therapeutic strategies.2  

Detailed phenotyping is the prerequisite for the development of precision and personalised medicine in chronic disease and particularly in OSA.3 The phenotyping of patients with OSA has been tackled in several different ways. One strategy has been to address the anatomical and physiological traits underlying OSA occurrence and the range of severity.4 The pathophysiological causes of OSA vary considerably between patients. Determining the respective contributions of upper airway anatomy and collapsibility, arousal threshold and loop gain (ventilator drive) will help to predict which therapeutic modality would be beneficial to the appropriately targeted patient subgroups.4 Another topic has been to define distinct OSA clinical phenotypes. Several recent studies exploiting large data sets have used unsupervised cluster analysis to identify distinct phenotypes.5 6 Subgroups have been recognised that varied considerably in age, gender, symptoms, obesity, comorbidities and environmental risk factors.5 6 The most significant differences between clusters were minimally symptomatic versus sleepy patients with OSA, lean versus obese, and among obese patients …
La place du traitement endoscopique dans l'angiocholite aiguë lithiasique (à propos de 109 cas)
Authors: S Mrabti, H Seddik, S Morabit, H Boutallaka, K Loubaris, A Aomari, S Jamal, F Bouhamou, S Sentissi, A Benkirane
Journal: Endoscopy (2018)

L'angiocholite aigue lithiasique est une infection bactérienne des voies biliaires due à un obstacle lithiasique. Il s'agit d'une urgence thérapeutique qui peut engager le pronostic vital. Le but de notre travail est d'évaluer les résultats du drainage endoscopique en urgence en cas d'angiocholite aigue lithiasique en matière d'extraction des calculs et d'amélioration de la morbidité et de la mortalité.
Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study
Authors: Elaine Setiawan, Sophia Attwells, Alan A Wilson, Romina Mizrahi, Pablo M Rusjan, Laura Miler, Cynthia Xu, Sarita Sharma, Stephen Kish, Sylvain Houle, Jeffrey H Meyer
Journal: The Lancet Psychiatry (2018)
肺動脈性肺高血圧におけるBMP/TGF-βシグナルの不均衡へのインターベンション・遺伝学研究による血管リモデリングへのポテンシャル治療
Authors: Ogo Takeshi, Takagi Yaemi, Miyaji Katsumasa, Nakanishi Norifumi, Rajiv Machado, Nasim Talat, Nick Morrell, Richard Trembath
Journal: Circulation (2012)
Abstract 11125: Increasing Stimulus Strength of Coronary Sinus Pacing Improved Left Ventricular Mechanical Dyssynchrony and Contractile Function in Patients With Reduced Ejection Fraction
Authors: Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Dokuni Kumiko, Yutaka Hatani, Keiko Hatazawa, Hiroaki Matsuzoe, Junichi Ooka, Hiroyuki Sano, Hiroyuki Shimoura, Takuma Sawa, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Koji Fukuzawa, Ken-ichi Hirata
Journal: Circulation (2015)

Introduction: Increasing stimulus strength of left ventricular (LV) coronary sinus pacing decreases QRS duration and inter-ventricular conduction time. Hypothesis: Increasing stimulus strength of LV coronary sinus pacing improves LV mechanical dyssynchrony and myocardial function. Methods: We studied 36 patients with 6±4 months after cardiac resynchronization therapy (LV ejection fraction: 39±11%). The LV pacing lead was positioned in lateral or posterolateral coronary sinus vein. We measured standard deviation (SD) of time to negative peak circumferential strain (time-CircS) in 6 segments and peak global circumferential strain value (CircS) using two-dimensional speckle-tracking echocardiography to evaluate LV mechanical dyssynchrony and myocardial contractile function, respectively. Low (1.3±0.6V), clinical (2.6±1.0V), and high (7.3±1.1V) voltage conditions of LV coronary sinus pacing were performed under right ventricular pacing-off. Results: SD of time-CircS and global CircS under high voltage LV coronary sinus pacing was significantly better than those under low and clinical voltage (78±38 vs. 90±48 and 92±43msec, p=0.014 and 0.016; 5.7±3.4 vs. 5.4±3.3 and 5.4±3.4%, p=0.007 and 0.003). Moreover, global CircS significantly correlated with SD of time-CircS (r= -0.54, p&lt;0.001, n=108). Conclusions: Increasing stimulus strength of LV coronary sinus pacing improved LV mechanical dyssynchrony and LV contractile function, leading clinical implication for better management of heart failure patients with cardiac resynchronization therapy.
Le traitement endoscopique des sténoses bénignes de l'oesophage
Authors: I Elhidaoui, H Sghir, S Oubaha, Z Samlani, K Krati
Journal: Endoscopy (2018)

Les sténoses bénignes de l'oesophage constituent une complication redoutable de nombreuses pathologies. Leur gravité émane du risque de l'installation de troubles hydro-électrolytiques sévères secondaires à la dénutrition. La fibroscopie oeso-gastro-duodénale permet généralement de poser le diagnostic étiologique. Le traitement repose essentiellement sur la dilatation endoscopique.
P097 ANTI-TNF treatment improves vascular function via suppression of GALECTIN-3 expression during inflammatory arthritis
Authors: K Sime, E Hughes, EH Choy, AS Williams
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Introduction</h3> The link between rheumatoid arthritis (RA) and cardiovascular disease (CVD) is well established but not yet fully understood. Anti-TNF treatment, e.g. with Enbrel, is one of most common therapies used in RA patients and has been shown to have beneficial effects on RA-associated cardiovascular pathologies in these patients.<sup>1</sup> Initial studies in the collagen-induced arthritis (CIA) model revealed an increase in cardiac fibrosis marker galectin-3, both locally in perivascular adipose tissue (PVAT) and systemically in blood plasma during inflammatory arthritis and correlated with impaired vascular function.<sup>2</sup> <h3>Objectives</h3> This study aims to investigate the impact of anti-TNF treatment on galectin-3 expression and vascular function during CIA. <h3>Methods</h3> Male DBA/1 mice underwent CIA induction and received either Enbrel or phosphate buffered saline (PBS) by intravenous injection. Vascular function was determined by measuring the constriction response of the thoracic aorta at termination using a myograph. Galectin-3 was measured locally in thoracic PVAT by immunohistochemistry and quantitative polymerise chain reaction (qPCR), and systemically by ELISA. <h3>Results</h3> Anti-TNF treatment during CIA resulted in a decrease in arthritis severity and progression compared to PBS treated mice, and partially restored vascular function. Galectin-3 expression was significantly reduced in thoracic PVAT, but not in blood plasma, in CIA mice treated with Enbrel. <h3>Conclusions</h3> In conclusion, decreased galectin-3 expression in Enbrel treated mice is associated with an improvement in arthritis-associated disease activity including arthritis clinical score, joint swelling and vascular function. <h3>References</h3> . Allanore Y, Avouac J. Cardiovascular risk in rheumatoid arthritis: Effects of anti-TNF drugs. Expert Opin Pharmacother2008May;9(7):1121–8. doi:10.1517/14656566.9.7.1121 . Sime K, Choy EH, Williams AS. Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice. Adipocyte2017April 3;6(2):87–101. doi:10.1080/21623945.2017.1295174 (Accessed: 2017 February 21). <h3>Disclosure of interest</h3> None declared
Significance of the expression of pyrimidine metabolic enzymes in colorectal cancer tissue
Authors: Yoshito Akagi, Tomoaki Mizobe, Kazuo Shirouzu, Masayoshi Kage, Akihiko Kawahara, Michihiko Kuwano
Journal: Cancer Research (2008)

1290  Introduction and purpose:  The chemotherapy for colon cancer has progressed remarkably. Its key drag is 5-FU(5-Fluorouracil). 5-FU shows antitumor effect after it was metabolized by many enzymes. Therefore, the characteristic expression of some enzymes on a metabolic pathway of 5-FU in carcinoma is extremely important. The research about relationship between expression of enzyme and clinicopathologic factor and/or between expression of enzyme and effective prediction has been reported. Then we attempted to examine the expression of a pyrimidine metabolism enzymes in colon cancer tissue using immunohistchemical staining  Material and methods:  The specimens of forty advanced colon cancers (20 cases of no recurrence, 10 cases of liver metastasis, 10 cases of pulmonary metastasis) were used.  Antibody of DPD (dihydropyrimidine dehydrogenese), ORPT (orotate phosphoribosyl transferase), TS (thymidylate synthase), TP (thymidine phosphorylase), TK (thymidine kinase) were used, and tumor specimens were blindly scored for expression levels. Associations of each antibody expression level with their characteristic and metastasis to liver or lung.  Results:  The strong expression in a primary tumor is respectively DPD; 47%, OPRT; 75%, TS; 20%, TK; 65%, TP; 22.5%. Between each enzymes, the expression of DPD and TK was indicated positive correlation (p=0.002). The strong expression of TS was poor prognosis (p=0.0001). The combination of negative DPD and strong OPRT was occurred 60%(9/15) of recurrence. Especially in 8 cases were metastases to lung. The combination of strong expression of both DPD and OPRT occurred 60%(9/15) of recurrence. Especially in 8 cases were metastases to liver.  Conclusion:  The expression of pyrimidine metabolism enzyme in colon cancer tissue is varied, and there are few correlation in each. The examination of plural enzyme expression is necessary for an effect prediction of 5FU. However, in the recurrence part, it seems that DPD and OPRT might play an important role.
Abstract 16898: Time Course and Associated Cardiac Conditions of Reduced Left Ventricular Ejection Fraction in Patients With Severe Aortic Stenosis
Authors: Saki Ito, Vuyisile T Nkomo, Sorin V Pislaru, Jeremy J Thaden, Kevin L Greason, Patricia A Pellikka, Jae K Oh
Journal: Circulation (2015)

Objective: In patients with aortic stenosis (AS), the development of left ventricular (LV) systolic dysfunction adversely affects the natural history and is associated with poor outcomes following aortic valve replacement. However, the timing and possible reasons for transition from preserved to impaired LV ejection fraction (LVEF) in patients with AS have not been described. The aim of this study was to describe the time course of development of LV dysfunction and associated conditions in patients with severe AS. Methods &amp; Results: Between 1/1/2009 and 12/31/2012, 667 (19%) of 3528 patients with severe AS (aortic valve area (AVA) ≤1 cm2) identified from the Mayo Clinic, Rochester, MN Echocardiographic Laboratory database; had LVEF ≤50%. Of those 667 patients, 263 (39%) had previous echocardiograms (median: 71.6 months, 25 IQR: 36.3, 75:118.2) before the development of severe AS, allowing an assessment of change in LVEF over time. Among these 263 patients, 8 (3%) had dilated cardiomyopathy (DCM), 225 (86%) had ischemic heart disease (IHD), 5 (2%) had other significant valve disease, and 25 (10%) had no concomitant heart disease before the development of severe AS. The evolution of development of reduced LVEF at several time points is shown in the Figure. The initial LVEF was 34±12 % in DCM patients, 51±13% in IHD patients and 61±9 % in AS patients without other heart diseases (p&lt;0.001, ANOVA). Patients with AS alone or AS+DCM/IHD showed a gradual decline in LVEF before AS became severe, and a more rapid decline in LVEF once the AVA reached ≤ 1 cm2. Conclusion: In patients with severe AS, a majority of the patients (86%) with reduced EF had ischemic heart disease. Although there was a gradual decline in LVEF before development of severe AS, the decline was more rapid after AS became severe in almost all patients regardless of associated cardiac condition. More frequent monitoring may be indicated in AS patients especially when AVA reaches 1cm2 and concomitant IHD.
Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial
Authors: Cindy L. Amundsen, Yuko M. Komesu, Christopher Chermansky, W. Thomas Gregory, Deborah L. Myers, Emily F. Honeycutt, Sandip P. Vasavada, John N. Nguyen, Tracey S. Wilson, Heidi S. Harvie, Dennis Wallace
Journal: European Urology (2018)
Relapse and Recurrence of Common Mental Health Problems after Low Intensity Cognitive Behavioural Therapy: The WYLOW Longitudinal Cohort Study
Authors: Jaime Delgadillo, Laura Rhodes, Omar Moreea, Dean McMillan, Simon Gilbody, Chris Leach, Mike Lucock, Wolfgang Lutz, Shehzad Ali
Journal: Psychotherapy and Psychosomatics (2018)
L'anxiété: facteur de mauvaise acceptabilité de l'endoscopie digestive haute sans sédation
Authors: Z Hassini, M Tahiri Joutei Hassani, W Hliwa, F Haddad, W Badre
Journal: Endoscopy (2018)

La fibroscopie oesogastroduodénale (FOGD) est l'examen de référence en matière d'exploration du tractus digestif haut. Elle a un double intérêt diagnostique et thérapeutique. L'évaluation du confort du patient au cours de cet examen est importante dans le contexte de l'amélioration de la «qualité de vie» des patients. D'autant plus que certains subissent cet examen de manière itérative.
Generalized Lichen Nitidus Following Anti–PD-1 Antibody Treatment
Authors: Maria Cho, Yumi Nonomura, Yo Kaku, Teruki Dainichi, Atsushi Otsuka, Kenji Kabashima
Journal: JAMA Dermatology (2018)

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Short Course of Lolium Perenne Peptides (LPP) Immunotherapy Induces IL-35 + T Regulatory Cells (iTr35) that Promote B Regulatory Cells (Bregs) and Blocking Antibodies
Authors: Iesha Singh, Hanisah Sharif, Lubna Kouser, Angeliki Karamani, Uday Kishore, Gabriële Holtappels, Lara Derycke, Rémy von Frenckell, Nathalie Wathelet, Jean Duchateau, Thierry Legon, Sabine Pirotton, Ralph Mosges, Stephen R. Durham, Claus Bachert, Mohamed H. Shamji
Journal: Journal of Allergy and Clinical Immunology (2018)
Hémorragie digestive haute de l'enfant de moins de 10 ans: aspects diagnostiques, pronostiques et thérapeutiques à propos de 14 patients
Authors: PE Itoudi Bignoumba, I Maganga Moussavou, JB Moussavou Kombila
Journal: Endoscopy (2018)

L'hémorragie digestive haute est l'une des principales urgences en gastroentérologie. Son pronostic est fonction de l'étiologie, du plateau technique et de la précocité de sa prise en charge.