Remission of Psoriasis After Treatment of Chronic Hepatitis C Virus Infection With Direct-Acting Antivirals
Authors: Masaru Enomoto, Chiharu Tateishi, Daisuke Tsuruta, Akihiro Tamori, Norifumi Kawada
Journal: Annals of Internal Medicine (2018)

Letters1 May 2018Remission of Psoriasis After Treatment of Chronic Hepatitis C Virus Infection With Direct-Acting AntiviralsMasaru Enomoto, MD, Chiharu Tateishi, MD, Daisuke Tsuruta, MD, Akihiro Tamori, MD, and Norifumi Kawada, MDMasaru Enomoto, MDOsaka City University, Osaka, Japan (M.E., C.T., D.T., A.T., N.K.)Search for more papers by this author, Chiharu Tateishi, MDOsaka City University, Osaka, Japan (M.E., C.T., D.T., A.T., N.K.)Search for more papers by this author, Daisuke Tsuruta, MDOsaka City University, Osaka, Japan (M.E., C.T., D.T., A.T., N.K.)Search for more papers by this author, Akihiro Tamori, MDOsaka City University, Osaka, Japan (M.E., C.T., D.T., A.T., N.K.)Search for more papers by this author, and Norifumi Kawada, MDOsaka City University, Osaka, Japan (M.E., C.T., D.T., A.T., N.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0613 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Hepatitis C virus (HCV) infection is a systemic disease with extrahepatic manifestations that include skin involvement, such as mixed cryoglobulinemia, lichen planus, and porphyria cutanea tarda (1). Some studies also suggest an association between HCV infection and psoriasis (2).Objective: To provide additional information about the possible association between HCV infection and psoriasis.Case Report: In September 2015, an 80-year-old man with a 9-year history of refractory psoriasis was referred to us. The patient had small, well-demarcated, pruritic, scaly erythema on the trunk and upper and lower extremities with a Psoriasis Area and Severity Index score of 8.3 (Figure ...References1. Sayiner M, Golabi P, Farhat F, Younossi ZM. Dermatologic manifestations of chronic hepatitis C infection. Clin Liver Dis. 2017;21:555-64. [PMID: 28689593] doi:10.1016/j.cld.2017.03.010 CrossrefMedlineGoogle Scholar2. Noe MH, Grewal SK, Shin DB, Ogdie A, Takeshita J, Gelfand JM. Increased prevalence of HCV and hepatic decompensation in adults with psoriasis: a population-based study in the United Kingdom. J Eur Acad Dermatol Venereol. 2017;31:1674-80. [PMID: 28485831] doi:10.1111/jdv.14310 CrossrefMedlineGoogle Scholar3. Snast I, Atzmony L, Braun M, Hodak E, Pavlovsky L. Risk for hepatitis B and C virus reactivation in patients with psoriasis on biologic therapies: a retrospective cohort study and systematic review of the literature. J Am Acad Dermatol. 2017;77:88-97. [PMID: 28495497] doi:10.1016/j.jaad.2017.01.037 CrossrefMedlineGoogle Scholar4. Afshar M, Martinez AD, Gallo RL, Hata TR. Induction and exacerbation of psoriasis with interferon-alpha therapy for hepatitis C: a review and analysis of 36 cases. J Eur Acad Dermatol Venereol. 2013;27:771-8. [PMID: 22671985] doi:10.1111/j.1468-3083.2012.04582.x CrossrefMedlineGoogle Scholar5. Heppt F, Sticherling M. Psoriasis as a manifestation of an immune reconstitution in two patients with hepatitis C treated with ledipasvir/sofosbuvir. Acta Derm Venereol. 2017;97:526-7. [PMID: 27868140] doi:10.2340/00015555-2582 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Osaka City University, Osaka, Japan (M.E., C.T., D.T., A.T., N.K.)Financial Support: Dr. Kawada has received lecture fees and research grants from Gilead Sciences.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0613.This article was published at Annals.org on 16 January 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTransient flare of psoriasis under direct‐acting antiviral therapy of chronic hepatitis C: A case reportEffectiveness and safety of chronic hepatitis C treatment with direct-acting antivirals in patients with rheumatic diseases: A case-seriesEffect of treating chronic hepatitis C with direct-acting antivirals on extrahepatic cutaneous manifestationsEffect of sofosbuvir plus daclatasvir for treatment of chronic hepatitis C on patients with psoriasisAnti-HCV for treatment of HCV-positive psoriatic patients: A promising therapy 1 May 2018Volume 168, Issue 9Page: 678-680KeywordsBiologicsCorticosteroid therapyCytokinesDisclosureHepatitis C virusInfectious hepatitisInflammationLesionsPsoriasisTreatment guidelines ePublished: 16 January 2018 Issue Published: 1 May 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...