tbuckley/cabot-search huggingface dataset:
La surveillance des données d’envois des ambulances comme instrument pour l’alerte rapide
Authors: K H Bork, B M Klein, K Mølbak, S Trautner, U B Pedersen, E Heegaard
Journal: Eurosurveillance (2006)

L’article suivant traite de l’evaluation et de la validation d’un algorithme de detection d’epidemies base sur des donnees d’envois d’ambulances, mis en place dans le cadre du programme national de surveillance des maladies au Danemark. 
La detection rapide d’epidemies est primordiale pour permettre aux autorites d’initier et mettre en place une reponse appropriee. Le besoin d’un systeme de detection des epidemies pour la surveillance de donnees anterieures aux confirmations de laboratoire a ete identifie, conduisant a l’etablissement d’un systeme inedit de surveillance des symptomes.
Le systeme de surveillance controle environ 80% de la populationo danoise en appliquant un algorithme de detection des epidemies aux donnees des envois d’ambulances. Ce systeme controle egalement l’activite regionale et nationale, et possede les moyens integres et disponibles de declencher une notification basee sur les symptomes en cas d’alerte. 
Une evaluation avec des scenarios detailles d’epidemies a permis de trouver que la diminution de la sensibilite de la detection des epidemies d’une limite predictive de 95% a une de 99% reduit moderement le temps de detection, mais diminue considerablement le nombre de fausses alertes. 
Le systeme a permis de detecter rapidement une activite accrue de syndromes grippaux en decembre 2003. Notre systeme fait partie a present du programme national de surveillance des maladies.
Are athletes psychologically ready for sport following a concussion?
Authors: Jeffrey G Caron, Gordon A Bloom, Leslie W Podlog
Journal: British Journal of Sports Medicine (2017)

Sport-related concussions have garnered increasing attention in recent years. Part of making sport safer at all levels of competition involves ensuring that concussions are properly managed. Graduated return to play (RTP)1 has been a widely implemented strategy to assist with concussion management. RTP is a six-stage process managed by health professionals that progressively increases athletes’ exertion until they are able to resume preconcussion activity levels.1 Graduated RTP should ensure athletes are physically and physiologically ready for competition. However, existing RTP criteria do not comprehensively account for psychological readiness for competition. Given that a lack of psychological readiness could lead to heightened competitive anxiety, hesitant performances and greater risk of secondary concussion after returning to sport, insufficiently attending to concussed athletes’ psychological readiness during RTP appears to be cause for concern and is worth examining.

Research on psychological aspects of sport injury has primarily focused on musculoskeletal injuries (eg, sprains, tears and fractures) and not concussions. Adolescent athletes have expressed concerns about the prospect of …
TCT-574 Bivalirudin versus Heparin in Aortic valve interventions: A Meta-analysis
Authors: Anurag Bajaj, Samir Pancholy, Arjinder Sethi, Pranjal Boruah, Arpit Sothwal, Qasim Malik, Gursukhmandeep Sidhu
Journal: Journal of the American College of Cardiology (2017)
PS02.07 Telemedicine: A New Era for the Treatment of Patients with Cancer
Authors: C. Lazzari, G.L. Ceresoli, A. Bearz, A.J. Ferreri, M. Mandalá, S. Cordio, G. Aprile, D. Ghio, C. Ferrari Da Passano, V. Gregorc
Journal: Journal of Thoracic Oncology (2017)
GP who tried to discredit colleague is struck off
Authors: Clare Dyer
Journal: BMJ (2017)

A GP who colluded with a friend to complain to the General Medical Council (GMC) about a practice colleague in a bid to discredit that colleague’s complaint against him has been struck off by a medical practitioners tribunal.

Jatin Patel was a senior partner at the Highfields Medical Centre in Leicester, a teaching practice founded by his father where he had worked for 30 years. One of the GPs employed there, named only as Dr B at Patel’s hearing, left the practice in January 2013. Four days later Patel learnt that a whistleblower had raised concerns …
The cytotoxic effects of dimethyl sulfoxide in mouse preimplantation embryos: a mechanistic study
Authors: Min-Hee Kang, Joydeep Das, Sangiliyandi Gurunathan, Hwan-Woo Park, Hyuk Song, Chankyu Park, Jin-Hoi Kim
Journal: Theranostics (2017)

Rationale: Dimethyl sulfoxide (DMSO) is commonly used as a solvent for water-insoluble substances, a vehicle for drug therapy, and a cryoprotectant for cultured cells. DMSO induced embryonic defects and its mechanism of action remains unclear. The rationale is based on the assumption that DMSO supplementation should induce long-term negative effects on both pre- and post-implantation embryo development. Methods: DMSO induced oxidative stress, ER stress, autophagy, mitophagy, signaling responsible genes and proteins were determined by RT-qPCR, Western blotting, immunofluorescence, and confocal microscopy. DMSO induced mitochondrial dysfunction was measured by transmission electron microcopy and JC-1 assay. Apoptosis was estimated using TUNEL and comet assay. Post-implantation embryo developmental capability was estimated by implantation site and fetus numbers. Results: Exposure to DMSO induced an early oxidative stress response within 0.5 to 2 h in 1-cell zygotes by disrupting the balance of pro- and anti-oxidants. Notably, DMSO-treated 2-cell embryos showed increased expression of unfolded protein response genes such as Hspa5, Hsp90b1, Ddit3, Atf4, and Xbp1. As a result, the development of many embryos is arrested at the 2-cell, 4-cell, or morula stages in a dose-dependent manner. Further, DMSO-induced endoplasmic reticulum stress increased mitochondrial Ca2+ levels, induced mitochondrial depolarization/dysfunction, and induced apoptotic cell death via the JNK/ATF2-dependent pathway. Consequently, treatment with DMSO increased the expression of autophagy initiation-, phagophore elongation-, and autophagosome formation-related genes, as well as localization of PINK1/Parkin, which are the main mediators of mitophagy, in mitochondria. Interestingly, DMSO causes cytotoxic effects in preimplantation embryos by inducing extensive mitophagy and autophagy. Especially, DMSO treatment decreased the inner cell mass and trophectoderm cell numbers as well as mRNA expression of B3gnt5 and Wnt3a in developed blastocysts, which decreased the implantation and developmental rates of full-term offspring after being transferred into pseudopregnant mice. Conclusion: These results provide a significant contribution to finding effective protective agents to combat DMSO mediated reproductive toxicity for application in human embryos in the near future.
Investigation of the international comparability of population-based routine hospital data set derived comorbidity scores for patients with lung cancer
Authors: Margreet Lüchtenborg, Eva J A Morris, Daniela Tataru, Victoria H Coupland, Andrew Smith, Roger L Milne, Luc te Marvelde, Deborah Baker, Jane Young, Donna Turner, Diane Nishri, Craig Earle, Lorraine Shack, Anna Gavin, Deirdre Fitzpatrick, Conan Donnelly, Yulan Lin, Bjørn Møller, David H Brewster, Andrew Deas, Dyfed W Huws, Ceri White, Janet Warlow, Jem Rashbass, Michael D Peake
Journal: Thorax (2017)

Introduction The International Cancer Benchmarking Partnership (ICBP) identified significant international differences in lung cancer survival. Differing levels of comorbid disease across ICBP countries has been suggested as a potential explanation of this variation but, to date, no studies have quantified its impact. This study investigated whether comparable, robust comorbidity scores can be derived from the different routine population-based cancer data sets available in the ICBP jurisdictions and, if so, use them to quantify international variation in comorbidity and determine its influence on outcome. Methods Linked population-based lung cancer registry and hospital discharge data sets were acquired from nine ICBP jurisdictions in Australia, Canada, Norway and the UK providing a study population of 233 981 individuals. For each person in this cohort Charlson, Elixhauser and inpatient bed day Comorbidity Scores were derived relating to the 4–36 months prior to their lung cancer diagnosis. The scores were then compared to assess their validity and feasibility of use in international survival comparisons. Results It was feasible to generate the three comorbidity scores for each jurisdiction, which were found to have good content, face and concurrent validity. Predictive validity was limited and there was evidence that the reliability was questionable. Conclusion The results presented here indicate that interjurisdictional comparability of recorded comorbidity was limited due to probable differences in coding and hospital admission practices in each area. Before the contribution of comorbidity on international differences in cancer survival can be investigated an internationally harmonised comorbidity index is required.
Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity
Authors: Wojciech Bobela, Sameer Nazeeruddin, Graham Knott, Patrick Aebischer, Bernard L. Schneider
Journal: Molecular Neurodegeneration (2017)

Metabolic perturbations and slower renewal of cellular components associated with aging increase the risk of Parkinson's disease (PD). Declining activity of AMPK, a critical cellular energy sensor, may therefore contribute to neurodegeneration. Here, we overexpress various genetic variants of the catalytic AMPKα subunit to determine how AMPK activity affects the survival and function of neurons overexpressing human α-synuclein in vivo. Both AMPKα1 and α2 subunits have neuroprotective effects against human α-synuclein toxicity in nigral dopaminergic neurons. Remarkably, a modified variant of AMPKα1 (T172Dα1) with constitutive low activity most effectively prevents the loss of dopamine neurons, as well as the motor impairments caused by α-synuclein accumulation. In the striatum, T172Dα1 decreases the formation of dystrophic axons, which contain aggregated α-synuclein. In primary cortical neurons, overexpression of human α-synuclein perturbs mitochondrial and lysosomal activities. Co-expressing AMPKα with α-synuclein induces compensatory changes, which limit the accumulation of lysosomal material and increase the mitochondrial mass. Together, these results indicate that modulating AMPK activity can mitigate α-synuclein toxicity in nigral dopamine neurons, which may have implications for the development of neuroprotective treatments against PD.
TCT-550 Comparative Clinical Outcomes with the Initial Use of Impella CP versus Impella 5.0 Devices in Patients with Severe Cardiogenic Shock
Authors: Rikin Tank, Richard Cheng, Danny Ramzy, Fardad Esmailian, Jon Kobashigawa, Jaime Moriguchi, Francisco Arabia, Babak Azarbal
Journal: Journal of the American College of Cardiology (2017)
Abstract 13254: Patient Education After CABG: Are We Teaching the Wrong Information?
Authors: Corey Bradley, Madelyn Burkart, Ravi Agarwala
Journal: Circulation (2016)

This article has been retracted. Please see: Notice of Retraction - http://circ.ahajournals.org/content/134/Suppl_1/suppl/DC1 Introduction: Secondary prevention after CABG improves morbidity and mortality, yet adherence remains poor. The inpatient stay for CABG is an invaluable teachable moment, and so it is imperative that the education we provide motivates adherence. There is limited data about whether patients identify their medications as preventive, or if this knowledge affects adherence behavior. Hypothesis: To determine if patient understanding of medication purpose and patient perception of medication importance affects adherence behavior. Methods: This was a prospective cohort study to evaluate medication adherence after discharge from CABG and CABG plus valve procedures at Wake Forest Baptist Hospital. A total of 49 patients met inclusion criteria and were enrolled. Participants were approached after receiving standardized nursing education before discharge and completed surveys addressing patient understanding of medication purpose and importance. Three months after discharge patients were contacted by phone and read the Morisky Medication Adherence Scale (MMAS-8), with a follow-up rate of 94%. Results: Only 27% of patients identified their cardiac medication regimen as lifelong and to promote future heart health. Most patients correctly identified the pharmacologic purpose of all 4 medications (aspirin, beta-blocker, ACEI, and statin). Significantly, 60% of patients with high adherence as defined by the MMAS-8 at 3 months had originally identified that daily use of their medications was important to maintaining long term health, while only 12% of those with low or medium adherence behaviors had identified the same (p = 0.000509). Conclusions: Patients appear to understand the mechanisms of action of cardiac medication but generally don’t appreciate their long-term preventative value. As such, patients may believe that they can discontinue the medications when objective criteria are met, such as lowered blood pressure, thus missing the potential benefit of decreased cardiac events and mortality.
Combined Safety Analysis for Japanese in Domestic Phase 1, Phase 1b and International Phase 2/3 Trials of Pembrolizumab
Authors: Atsushi Horiike, Hideo Saka, Hiroshi Tanaka, Terufumi Kato, Naoya Yamazaki, Kazuhiko Yamada, Kenji Yokota, Shunichi Sugawara, Kazuo Noguchi, Hidetoshi Hayashi
Journal: Annals of Oncology (2017)
RItA: The Italian severe/uncontrolled asthma registry
Authors: S. Maio, S. Baldacci, M. Bresciani, M. Simoni, M. Latorre, N. Murgia, F. Spinozzi, M. Braschi, L. Antonicelli, B. Brunetto, P. Iacovacci, P. Roazzi, C. Pini, M. Pata, L. La Grasta, P. Paggiaro, G. Viegi
Journal: Allergy (2017)

Abstract Background The Italian severe/uncontrolled asthma ( SUA ) web‐based registry encompasses demographic, clinical, functional, and inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. Methods Four hundred and ninety three adult patients from 27 Italian centers (recruited in 2011‐2014) were analyzed. Results Mean age was 53.8 years. SUA patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis/symptoms (&gt;40 years); the mean age for asthma symptoms onset was 30.2 years and for asthma diagnosis 34.4 years. 97.1% used ICS (dose 2000 BDP ), 93.6% LABA in association with ICS , 53.3% LTRA s, 64.1% anti‐IgE, 10.7% theophylline, and 16.0% oral corticosteroids. Mean FEV 1 % pred of 75.1%, median values of 300/mm 3 of blood eosinophil count, 323 kU /L of serum total IgE, and 24 ppb of FENO were shown. Most common comorbidities were allergic rhinitis (62.4%), gastroesophageal reflux (42.1%), sinusitis (37.9%), nasal polyposis (30.2%), and allergic conjunctivitis (30.2%). 55.7% of SUA patients had exacerbations in the last 12 months, 9.7% emergency department visits, and 7.3% hospitalizations. Factors associated with exacerbation risk were obesity ( OR , 95% CI 2.46, 1.11‐5.41), psychic disorders (2.87, 0.89‐9.30—borderline), nasal polyps (1.86, 0.88‐3.89—borderline), partial/poor asthma treatment adherence (2.54, 0.97‐6.67—borderline), and anti‐IgE use in a protective way (0.26, 0.12‐0.53). Comparisons to severe asthma multicenter studies and available registries showed data consistency across European and American populations. Conclusions An international effort in the implementation of SUA patients’ registries could help to better understand the clinical features and to manage severe asthma, representing a non‐negligible socioeconomic burden for health services.
Margaret McCartney: Doctors should care about cycling
Authors: Margaret McCartney
Journal: BMJ (2017)

Charlie Alliston was recently convicted of “wanton and furious driving” and jailed for 18 months. A pedestrian, Kim Briggs, was killed when Alliston, riding a bicycle that was not fitted with a front brake, collided with her in London in 2016.1

In the wake of his conviction we’ve heard significant murmurings from the media that cyclists, as part of a “minority activity,” have had it too easy. Some suggest that cyclists not only require some form of regulation but are responsible for causing car congestion, as bike lanes are allegedly underused.2 A police and crime commissioner in England has called for cyclists to have some kind of registration display.3

The government, in …
Leukemia Drug Makes a Comeback
Authors: Rebecca Voelker
Journal: JAMA (2017)

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Estudo da introdução da vacinação universal da gripe em idosos na Holanda
Authors: G. A. van Essen
Journal: Eurosurveillance (1998)

Durante muitos anos, na Holanda, a vacinacao da gripe tem sido administrada pelos clinicos gerais a populacao inscrita na sua lista de utentes. Nove em cada 10 consultorios medicos utilizam um dos seis sistemas de informacao de clinica geral aprovados (SICG: sistema de informacao em clinica geral). A crescente utilizacao de ficheiros medicos informatizados em paises como a Holanda e o Reino Unido pode ser considerada como um dos maiores progressos dos ultimos anos, no que respeita a prevencao, na populacao geral. A lista dos doentes e a automatizacao possibilitam uma prevencao sistematica em clinica geral.
KRAS Mutation and Consensus Molecular Subtypes 2 and 3 Are Independently Associated with Reduced Immune Infiltration and Reactivity in Colorectal Cancer
Authors: Neeraj Lal, Brian S. White, Ghaleb Goussous, Oliver Pickles, Mike J. Mason, Andrew D. Beggs, Philippe Taniere, Benjamin E. Willcox, Justin Guinney, Gary W. Middleton
Journal: Clinical Cancer Research (2017)

mutation is a common canonical mutation in colorectal cancer, found at differing frequencies in all consensus molecular subtypes (CMS). The independent immunobiological impacts of RAS mutation and CMS are unknown. Thus, we explored the immunobiological effects of
TCT-351 Temporal Trends and Factors Associated With Prolonged Length of Stay in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
Authors: Poonam Velagapudi, Dhaval Kolte, Kashif Ather, Sahil Khera, Tanush Gupta, Paul Gordon, Herbert Aronow, Ajay Jayant Kirtane, J. Dawn Abbott
Journal: Journal of the American College of Cardiology (2017)
David Oliver: The non-story of “NHS Airbnb”
Authors: David Oliver
Journal: BMJ (2017)

As the NHS approaches its busiest time of year, politicians and the media are ramping up their focus on very real winter pressures. Overcrowded emergency departments, ambulances stacked outside, and patients on trolleys in corridors, are sure to make headlines. And don’t forget a pandemic scare: this year it’s Australian flu. No laughing matter, but hardly the only significant challenge to the service or to population health.

In an NHS where even senior managers seem reluctant to speak out, it was good to see Dame Julie Moore, a hospital chief executive, doing so on Newsnight on 25 October.1 Seeing that even the best led hospitals are experiencing …
TCT-203 A distal mode of renal denervation in segmental branches of renal artery versus conventional main trunk therapy: a double blind randomized controlled study in patients with resistant hypertension
Authors: Andrei Baev, Stanislav Pekarskiy, Viktor Mordovin, Tatiana Ripp, Alla Falkovskaya, Valeria Lichikaki, Irina Zubanova, Galina Semke, Sergei Popov
Journal: Journal of the American College of Cardiology (2017)
Abstract 16116: Drug Eluting vs. Bare Metal Stents in Patients With Chronic Kidney Disease and Coronary Artery Disease: Insight From a Systematic Review and Meta-Analysis of Trials
Authors: Alexander Volodarskiy, Sunil Kumar, Sripal Bangalore
Journal: Circulation (2013)

Background:  Chronic kidney disease (CKD) is an independent risk factor for coronary artery disease (CAD) and is associated with an exponential increase in adverse outcomes. Most large clinical trials of drug eluting stents (DES) have excluded patients with impaired renal function. The efficacy of DES in patients with CKD is therefore not known.   Methods:  MEDLINE, EMBASE and CENTRAL were searched for studies including at least 100 patients with CKD or with a creatinine clearance of ≤ 60 mL/min and CAD treated with DES or bare metal stents (BMS) and followed for at least 1 month and reporting outcomes of all-cause mortality, cardiovascular (CV) mortality, myocardial infarction (MI), target lesion and target vessel revascularizations.   Results:  27 studies with 83,332 participants (47,073 DES and 36,259 BMS) fulfilled the criteria and were included in the analysis. DES was associated with significant reduction in all-cause mortality (OR 0.70; 95% CI 0.61-0.80), CV mortality (OR 0.39; 95% CI 0.25-0.60), MI (OR 0.90; 95% CI 0.85-0.95), TLR (OR 0.61; 95% CI 0.48-0.77) and TVR (OR 0.49; 95% CI 0.35-0.69) when compared with BMS alone (Figure).   Conclusions:  In CAD patients with CKD undergoing PCI, the current data from non-randomized studies indicate a significant benefit of DES when compared with BMS alone. These associations should be tested in future randomized controlled trials.