tbuckley/cabot-search huggingface dataset:
Abstract 18872: The Prognostic Utility of Risk Factors Defined by the AHA/ACCF Expert Consensus Statement on the Evaluation of Cardiac Disease in Liver Transplantation Candidates
Authors: Hena Patel, Sarah Alexander, Meron Teshome, Ahmad Alkhalil, Edie Chan, Rami Doukky
Journal: Circulation (2015)

Introduction: The 2012 AHA/ACCF expert consensus statement regarding cardiac evaluation of liver transplant candidates specifies 7 risk factors for identifying candidates for cardiac evaluation prior to liver transplantation. These include age &gt; 60 yrs, hypertension, diabetes, smoking, dyslipidemia, prior cardiovascular disease, and left ventricular hypertrophy. The prognostic value of these risk factors in predicting major adverse cardiac events (MACE) has not been established. Furthermore, the optimal threshold of the sum of risk factors to predict MACE has not been determined. Hypothesis: Risk factors set forth by the AHA/ACCF can predict MACE in liver transplant candidates. We sought to identify an optimal threshold sum of risk factors to predict MACE. Methods: We conducted a retrospective cohort study of consecutive liver transplant recipients who were followed for MACE, defined as a composite of cardiac death, myocardial infarction, or coronary revascularization. Kaplan-Meier plots, log-rank test, and Cox regression models were used in outcome analyses. Results: We retrospectively followed 193 consecutive liver transplant recipients (40% female, mean age 55±10 yrs) for a mean of 51±29 months, during which 24 MACE were observed. Having ≥2 AHA/ACCF risk factors was associated with increased MACE risk (HR, 2.75, P=0.02), whereas having ≥3 risk factors was associated with greater MACE risk (HR, 4.14, P&lt;0.001), Figure 1. Using ≥1 risk factor threshold provided insignificant predictive value of event-free survival (P=0.29). Conclusion: This study provides prognostic validation of risk factors set forth by the AHA/ACCF consensus statement for cardiac evaluation in liver transplant candidates. Having ≥2 risk factors is most sensitive for predicting MACE and seems optimal for triggering CAD surveillance in asymptomatic liver transplant candidates.
Wavelength Dependence of Tumor Induction by Ultraviolet Radiation
Authors: Harold F. Blum
Journal: JNCI Journal of the National Cancer Institute (1943)

Journal Article Wavelength Dependence of Tumor Induction by Ultraviolet Radiation Get access Harold F. Blum Harold F. Blum senior pharmacologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 3, Issue 5, June 1943, Pages 533–537, https://doi.org/10.1093/jnci/3.5.533 Published: 01 June 1943
Race/Ethnicity–Based Outcomes in Cardiovascular Medicine
Authors: Clyde W. Yancy, Ajay J. Kirtane
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury
Authors: Asvi A Francois, Kofo Obasanjo-Blackshire, James E Clark, Andrii Boguslavskyi, Mark R Holt, Peter J Parker, Michael S Marber, Richard J Heads
Journal: Cardiovascular Research (2017)

Abstract Aims PKN1 is a stress-responsive protein kinase acting downstream of small GTP-binding proteins of the Rho/Rac family. The aim was to determine its role in endogenous cardioprotection. Methods and results Hearts from PKN1 knockout (KO) or wild type (WT) littermate control mice were perfused in Langendorff mode and subjected to global ischaemia and reperfusion (I/R). Myocardial infarct size was doubled in PKN1 KO hearts compared to WT hearts. PKN1 was basally phosphorylated on the activation loop Thr778 PDK1 target site which was unchanged during I/R. However, phosphorylation of p42/p44-MAPK was decreased in KO hearts at baseline and during I/R. In cultured neonatal rat ventricular cardiomyocytes (NRVM) and NRVM transduced with kinase dead (KD) PKN1 K644R mutant subjected to simulated ischaemia/reperfusion (sI/R), PhosTag® gel analysis showed net dephosphorylation of PKN1 during sI and early R despite Thr778 phosphorylation. siRNA knockdown of PKN1 in NRVM significantly decreased cell survival and increased cell injury by sI/R which was reversed by WT- or KD-PKN1 expression. Confocal immunofluorescence analysis of PKN1 in NRVM showed increased localization to the sarcoplasmic reticulum (SR) during sI. GC-MS/MS and immunoblot analysis of PKN1 immunoprecipitates following sI/R confirmed interaction with CamKIIδ. Co-translocation of PKN1 and CamKIIδ to the SR/membrane fraction during sI correlated with phospholamban (PLB) Thr17 phosphorylation. siRNA knockdown of PKN1 in NRVM resulted in increased basal CamKIIδ activation and increased PLB Thr17 phosphorylation only during sI. In vivo PLB Thr17 phosphorylation, Sarco-Endoplasmic Reticulum Ca2+ ATPase (SERCA2) expression and Junctophilin-2 (Jph2) expression were also basally increased in PKN1 KO hearts. Furthermore, in vivo P-V loop analysis of the beat-to-beat relationship between rate of LV pressure development or relaxation and end diastolic P (EDP) showed mild but significant systolic and diastolic dysfunction with preserved ejection fraction in PKN1 KO hearts. Conclusion Loss of PKN1 in vivo significantly reduces endogenous cardioprotection and increases myocardial infarct size following I/R injury. Cardioprotection by PKN1 is associated with reduced CamKIIδ-dependent PLB Thr17 phosphorylation at the SR and therefore may stabilize the coupling of SR Ca2+ handling and contractile function, independent of its kinase activity.
TCT-766 Long term results of access related vascular complications following TAVI
Authors: Yoni Grossman, Israel Barbash, Anat Berkovitch, Fernando Chernomordik, Yafim Brodov, Amit Segev, Elad Asher, Dan Elian, Arwa Younis, Sagit Ben Zekry, Victor Guetta, Paul Fefer
Journal: Journal of the American College of Cardiology (2017)
Cutaneous metastasis as the first presentation of hepatocellular carcinoma
Authors: Neil Patel, Gemma Sheehan‐Dare, Justin Weir, Suman Verma, Louise Fearfield
Journal: Hepatology (2017)

Patel, Neil; Sheehan‐Dare, Gemma; Weir, Justin; Verma, Suman; Fearfield, Louise Author Information
Defining potential mechanisms by which Cables is lost in ovarian cancer
Authors: Sakamoto Hideo, Rosemary Foster, Michael V. Seiden, Esther Oliva, Daniel C. Chung, Maureen P. Lynch, Lawrence R. Zukerberg, Bo R. Rueda
Journal: Cancer Research (2006)

1547   Cables is a novel cyclin-dependent kinase (cdk) binding protein that maps to human chromosome 18q11-12. Cables appears to be primarily involved in cell cycle regulation and cell proliferation. Loss of Cables expression is observed in many human cancers, such as colon, lung, and gynecological malignancies. Previously we reported that loss of Cables expression was observed with high frequency in ovarian serous carcinomas, whereas strong Cables staining was detected in all ovarian clear cell and mucinous tumors. However, the exact mechanisms which suppress Cables function are unclear. Predominant mechanisms of gene inactivation include loss of heterozygosity (LOH) and/or specific mutation. Method: We analyzed both normal tissue and primary ovarian serous carcinomas for evidence of Cables LOH using well-characterized markers which flank the Cables locus on chromosome 18. Briefly, DNA was extracted from paraffin embedded normal and tumor tissue from the same patient and LOH was evaluated using the highly polymorphic markers D18S44 and D18S1107. We also assessed whether the Cables gene is a frequent target of mutation in ovarian serous carcinoma. DNA extracted from ovarian serous carcinomas, benign ovarian tumors and genomic DNA from corresponding blood samples was PCR-amplified and sequenced for all exons (1-10) of the Cables gene. Massachusetts General Hospital IRB permission was obtained for use of discarded human tissue/cells derived from MGH Pathology and MGH Ovarian Tumor Bank (M.V.S and R.F.). Results: We observed loss of heterozygosity of chromosome 18 in 6 of 22 ovarian serous carcinomas in at least one of the polymorphic markers analyzed. Our ongoing mutation analysis has detected heterozygous nucleotide alterations in the Cables coding sequence. Conclusions: Our analyses provide evidence to suggest that the loss or suppression of Cables, which is common in ovarian cancer, may be due in part to LOH of chromosome 18 and/or heterozygous nucleotide alterations in the Cables coding sequence. Studies were supported in part by RO1 CA 98333 (BRR) and Advanced Medical Research Foundation (BRR).
Randomized Trial of ConquerFear: A Novel, Theoretically Based Psychosocial Intervention for Fear of Cancer Recurrence
Authors: Phyllis N. Butow, Jane Turner, Jemma Gilchrist, Louise Sharpe, Allan Ben Smith, Joanna E. Fardell, Stephanie Tesson, Rachel O’Connell, Afaf Girgis, Val J. Gebski, Rebecca Asher, Cathrine Mihalopoulos, Melanie L. Bell, Karina Grunewald Zola, Jane Beith, Belinda Thewes
Journal: Journal of Clinical Oncology (2017)

Purpose Fear of cancer recurrence (FCR) is prevalent, distressing, and long lasting. This study evaluated the impact of a theoretically/empirically based intervention (ConquerFear) on FCR. Methods Eligible survivors had curable breast or colorectal cancer or melanoma, had completed treatment (not including endocrine therapy) 2 months to 5 years previously, were age > 18 years, and had scores above the clinical cutoff on the FCR Inventory (FCRI) severity subscale at screening. Participants were randomly assigned at a one-to-one ratio to either five face-to-face sessions of ConquerFear (attention training, metacognitions, acceptance/mindfulness, screening behavior, and values-based goal setting) or an attention control (Taking-it-Easy relaxation therapy). Participants completed questionnaires at baseline (T0), immediately post-therapy (T1), and 3 (T2) and 6 months (T3) later. The primary outcome was FCRI total score. Results Of 704 potentially eligible survivors from 17 sites and two online databases, 533 were contactable, of whom 222 (42%) consented; 121 were randomly assigned to intervention and 101 to control. Study arms were equivalent at baseline on all measured characteristics. ConquerFear participants had clinically and statistically greater improvements than control participants from T0 to T1 on FCRI total ( P < .001) and severity subscale scores ( P = .001), which were maintained at T2 ( P = .017 and P = .023, respectively) and, for FCRI total only, at T3 ( P = .018), and from T0 to T1 on three FCRI subscales (coping, psychological distress, and triggers) as well as in general anxiety, cancer-specific distress (total), and mental quality of life and metacognitions (total). Differences in FCRI psychological distress and cancer-specific distress (total) remained significantly different at T3. Conclusion This randomized trial demonstrated efficacy of ConquerFear compared with attention control (Taking-it-Easy) in reduction of FCRI total scores immediately post-therapy and 3 and 6 months later and in many secondary outcomes immediately post-therapy. Cancer-specific distress (total) remained more improved at 3- and 6-month follow-up.
Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology
Authors: Jennifer A Brody, Alanna C Morrison, Joshua C Bis, Jeffrey R O'Connell, Michael R Brown, Jennifer E Huffman, Darren C Ames, Andrew Carroll, Matthew P Conomos, Stacey Gabriel, Richard A Gibbs, Stephanie M Gogarten, Namrata Gupta, Cashell E Jaquish, Andrew D Johnson, Joshua P Lewis, Xiaoming Liu, Alisa K Manning, George J Papanicolaou, Achilleas N Pitsillides, Kenneth M Rice, William Salerno, Colleen M Sitlani, Nicholas L Smith, Susan R Heckbert, Cathy C Laurie, Braxton D Mitchell, Ramachandran S Vasan, Stephen S Rich, Jerome I Rotter, James G Wilson, Eric Boerwinkle, Bruce M Psaty, L Adrienne Cupples
Journal: Nature Genetics (2017)
PS01.06 Feasibility of Salvage Pulmonary Resection after Definitive Chemoradiotherapy for Advanced Non-Small Cell Lung Cancer Patients
Authors: A.K. Kobayashi, H. Horinouchi, Y. Ito, Y. Oe, S. Uchida, K. Asakura, Y. Yoshida, K. Nakagawa, S. Watanabe
Journal: Journal of Thoracic Oncology (2017)
Screening Children at Risk for Retinoblastoma
Authors: Alison H. Skalet, Dan S. Gombos, Brenda L. Gallie, Jonathan W. Kim, Carol L. Shields, Brian P. Marr, Sharon E. Plon, Patricia Chévez-Barrios
Journal: Ophthalmology (2017)

PurposeTo provide a set of surveillance guidelines for children at risk for development of retinoblastoma.DesignConsensus panel.ParticipantsExpert panel of ophthalmic oncologists, pathologists, and geneticists.MethodsA group of members of the American Association of Ophthalmic Oncologists and Pathologists (AAOOP) with support of the American Association for Pediatric Ophthalmology and Strabismus and the American Academy of Pediatrics (AAP) was convened. The panel included representative ophthalmic oncologists, pathologists, and geneticists from retinoblastoma referral centers located in various geographic regions who met and discussed screening approaches for retinoblastoma. A patient "at risk" was defined as a person with a family history of retinoblastoma in a parent, sibling, or first- or second-degree relative.Main Outcome MeasuresScreening recommendations for children at risk for retinoblastoma.ResultsConsensus statement from the panel: (1) Dedicated ophthalmic screening is recommended for all children at risk for retinoblastoma above the population risk. (2) Frequency of examinations is adjusted on the basis of expected risk for RB1 mutation. (3) Genetic counseling and testing clarify the risk for retinoblastoma in children with a family history of the disease. (4) Examination schedules are stratified on the basis of high-, intermediate-, and low-risk children. (5) Children at high risk for retinoblastoma require more frequent screening, which may preferentially be examinations under anesthesia.ConclusionsRisk stratification including genetic testing and counseling serves as the basis for screening of children at elevated risk for development of retinoblastoma.
TCT-27 What is the Most Effective Treatment After Rotational Atherectomy for Stent Underexpansion? An Inverse Probability of Treatment Weighting Analysis Based on Propensity Score
Authors: Daisuke Hahcinohe, Yoshifumi Kashima, Morio Enomoto, Daitarou Kanno, Ken Kobayashi, Takuro Sugie, Umihiko Kaneko, Yutaka Tadano, Tomohiko Watanabe, Hidemasa Shitan, Takatoyo Kiko, Tsutomu Fujita
Journal: Journal of the American College of Cardiology (2017)
Autorefraction-Based Prescription and Mailed Delivery of Eyeglasses
Authors: Prateek Gajwani, Varshini Varadaraj, William Plum, Di Zhao, Egwuonwu Johnson, Niccolo Dosto, Sean Thompson, Eliseo Guallar, Natasha Kanwar, David S Friedman, Lucy I Mudie
Journal: Ophthalmology (2017)
LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease
Authors: Christopher P. Larsen, Claire Trivin-Avillach, Paige Coles, A. Bernard Collins, Michael Merchant, Hong Ma, Daniel W. Wilkey, Josephine M. Ambruzs, Nidia C. Messias, L. Nicholas Cossey, Ivy A. Rosales, Thomas Wooldridge, Patrick D. Walker, Robert B. Colvin, Jon Klein, David J. Salant, Laurence H. Beck
Journal: Journal of the American Society of Nephrology (2017)

Export Primary renal tubulointerstitial disease resulting from proximal tubule antigen–specific antibodies and immune complex formation has not been well characterized in humans. We report a cohort of patients with a distinct, underappreciated kidney disease characterized by kidney antibrush border antibodies and renal failure (ABBA disease). We identified ten patients with ABBA disease who had a combination of proximal tubule damage, IgG-positive immune deposits in the tubular basement membrane, and circulating antibodies reactive with normal human kidney proximal tubular brush border. All but one of the patients also had segmental glomerular deposits on renal biopsy specimen. Patients with ABBA disease were elderly and presented with AKI and subnephrotic proteinuria. Serum from all patients but not controls recognized a high molecular weight protein in renal tubular protein extracts that we identified as LDL receptor-related protein 2 (LRP2), also known as megalin, by immunoprecipitation and mass spectrometry. Immunostaining revealed that LRP2 specifically colocalized with IgG in the tubular immune deposits on the ABBA biopsy specimen but not the control specimen analyzed. Finally, ABBA serum samples but not control samples showed reactivity against recombinantly expressed N-terminal LRP2 fragments on Western blots and immunoprecipitated the recombinantly expressed N-terminal region of LRP2. This case series details the clinicopathologic findings of patients with ABBA disease and shows that the antigenic target of these autoantibodies is LRP2. Future studies are needed to determine the disease prevalence, stimulus for ABBA, and optimal treatment.
TCT-686 There’s More to the ECG: Predictors of Complete Heart Block after Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy
Authors: Justin Heizer, Laura Divoky, Jeremy Rier, Amy Wahlquist, Ashley Waring, Shawn Shaji, Sheldon Litwin, Michael Gold, Valerian Fernandes, Christopher Nielsen
Journal: Journal of the American College of Cardiology (2017)
From concept to in vivo testing: Microcontainers for oral drug delivery
Authors: Chiara Mazzoni, Fabio Tentor, Sophie Andersen Strindberg, Line Hagner Nielsen, Stephan Sylvest Keller, Tommy Sonne Alstrøm, Carsten Gundlach, Anette Müllertz, Paolo Marizza, Anja Boisen
Journal: Journal of Controlled Release (2017)
Hepatitis C aguda en hombres homosexuales VIH positivos. Paris, Francia, 2001-2004
Authors: L Gambotti
Journal: Eurosurveillance (2005)

En 2004, tres servicios hospitalarios parisinos informaron al Institut de veille sanitaire de casos recientes de hepatitis C aguda en hombres que tenian relaciones sexuales con otros hombres (HRSH), infectados por el VIH (VIH+), en los cuales no se encontraron los modos usuales de transmision sanguinea del virus de la hepatitis C (VHC), y que habian tenido relaciones no protegidas. En octubre de 2004, se llevo a cabo un estudio retrospectivo de los casos de hepatitis C aguda en los HRSH VIH+ en los hospitales parisinos, buscando los factores de riesgo de transmision del VHC. A partir de las historias clinicas se recogieron las caracteristicas demograficas, el estado clinico y biologico de la infeccion por VIH, las razones del cribado frente al VHC, el comportamiento sexual y los factores de riesgo de transmision del VHC en los seis meses precedentes a la hepatitis aguda. 
Tambien se proporciono a todos los casos un auto-cuestionario anonimo sobre el comportamiento sexual durante los seis meses anteriores a la ocurrencia de la hepatitis. En total, fueron identificados 29 casos de hepatitis C aguda con inicio de sintomas entre los meses de abril de 2001 y octubre de 2004 en HRSH VIH+. La infeccion por el VIH era asintomatica para el 76% de ellos. La edad mediana en el momento de la infeccion por el virus de la hepatitis fue de 40 anos (28-54). Todos los casos habian tenido relaciones anales no protegidas, un 21% habian practicado “fisting” y el 41% tenian una infeccion de transmision sexual (ITS) concomitante a la hepatitis. El periodo mediano entre los diagnosticos de infecciones por VIH y la hepatitis C era de 6,5 anos (0-22). De los 11 auto-cuestionarios, diez declaraban una ITS, ocho practicas sexuales “duras”, seis sangrados durante las relaciones y cinco la practica de “fisting”. La transmision del VHC en los hombres homosexuales VIH+ podria ser debida a sangrados durante las relaciones anales no protegidas y traumaticas y ser facilitada por lesiones mucosas asociadas a una ITS. Este estudio subraya de nuevo la necesidad de recomendar las practicas sexuales seguras entre los homosexuales varones.
Prospective Comparison of Gd-EOB-DTPA-Enhanced MRI with Dynamic CT for Detecting Recurrence of HCC after Radiofrequency Ablation
Authors: Yasuharu Imai, Kazuhiro Katayama, Masatoshi Hori, Takayuki Yakushijin, Kenji Fujimoto, Toshifumi Itoh, Takumi Igura, Mitsuru Sakakibara, Manabu Takamura, Masakatsu Tsurusaki, Hiroto Takahashi, Katsuyuki Nakanishi, Noriaki Usuki, Koh Tsuji, Hiroshi Ohashi, Tonsok Kim, Tetsuo Takehara, Takamichi Murakami
Journal: Liver Cancer (2017)

We prospectively compared the efficacy of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) with that of dynamic multidetector computed tomography (MDCT) for detection of recurrent hypervascular hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA).Institutional review board approval and written informed consent were obtained for this multicenter study. Ninety-seven HCC patients treated with curative RFA underwent both Gd-EOB-DTPA-enhanced MRI and dynamic MDCT every 3-4 months. HCC diagnosis was made based on the typical enhancement pattern of HCC on MRI and/or CT by on-site consensus reading. Two blinded observers independently assessed image datasets to compare diagnostic accuracy, sensitivity, specificity, and the areas under the receiver operating characteristic curve (AUROC).Recurrence was observed in 48 of 97 patients. Among these, 22 were diagnosed by both Gd-EOB-DTPA-enhanced MRI and MDCT; the remainder were diagnosed by only one of these 2 modalities. Recurrence was diagnosed in more patients by Gd-EOB-DTPA-enhanced MRI than by MDCT (44 vs. 26 patients, p < 0.001). Patient-based analysis revealed that the accuracy, sensitivity, and AUROC of Gd-EOB-DTPA-enhanced MRI were significantly higher than those of MDCT for both observers (p < 0.005). The AUROC of Gd-EOB-DTPA- enhanced MRI and MDCT was 0.95 and 0.76 for observer 1 and 0.90 and 0.74 for observer 2, respectively. The κ values for MRI and MDCT were 0.83 and 0.70, respectively.Compared with dynamic MDCT, Gd-EOB-DTPA-enhanced MRI had higher diagnostic accuracy and sensitivity for detection of recurrent hypervascular HCC and may be a better tool for following patients after RFA.
TCT-581 Impact of severe annular dilatation in the recurrence of mitral regurgitation after percutaneous edge-to-edge mitral valve repair
Authors: Tomas Benito-González, Rodrigo Estevez, Carmen Garrote, David Alonso, Armando Perez de Prado, Laura Romero-Roche, Carlos Cuellas-Ramon, Maria Lopez-Benito, Ignacio Iglesias-Garriz, Javier Gualis-Cardona, Mario Castaño, Felipe Fernandez-Vazquez
Journal: Journal of the American College of Cardiology (2017)