tbuckley/cabot-search huggingface dataset:
Long-Term Potassium Monitoring and Dynamics in Heart Failure and Risk of Mortality
Authors: Julio Núñez, Antoni Bayés-Genís, Faiez Zannad, Patrick Rossignol, Eduardo Núñez, Vicent Bodí, Gema Miñana, Enrique Santas, Francisco J. Chorro, Anna Mollar, Arturo Carratalá, Jorge Navarro, Jose Luis Górriz, Josep Lupón, Oliver Husser, Marco Metra, Juan Sanchis
Journal: Circulation (2017)

Background: The prognostic value of long-term potassium monitoring and dynamics in heart failure has not been characterized completely. We sought to determine the association between serum potassium values collected at follow-up with all-cause mortality in a prospective and consecutive cohort of patients discharged from a previous acute heart failure admission. Methods: Serum potassium was measured at every physician-patient encounter, including hospital admissions and ambulatory settings. The multivariable-adjusted association of serum potassium with mortality was assessed by using comprehensive state-of-the-art regression methods that can accommodate time-dependent exposure modeling. Results: The study sample included 2164 patients with a total of 16 116 potassium observations. Mean potassium at discharge was 4.3±0.48 mEq/L. Hypokalemia (&lt;3.5 mEq/L), normokalemia (3.5–5.0 mEq/L), and hyperkalemia (&gt;5 mEq/L) were observed at the index admission in 77 (3.6%), 1965 (90.8%), and 122 (5.6%) patients, respectively. At a median follow-up of 2.8 years (range, 0.03–12.8 years), 1090 patients died (50.4%). On a continuous scale, the multivariable-adjusted association of potassium values and mortality revealed a nonlinear association (U-shaped) with higher risk at both ends of its distribution (omnibus P =0.001). Likewise, the adjusted hazard ratios for hypokalemia and hyperkalemia, normokalemia as reference, were 2.35 (95% confidence interval, 1.40–3.93; P =0.001) and 1.55 (95% confidence interval, 1.11–2.16; P =0.011), respectively (omnibus P =0.0003). Furthermore, dynamic changes in potassium were independently associated with substantial differences in mortality risk. Potassium normalization was independently associated with lower mortality risk ( P =0.001). Conclusions: Either modeled continuously or categorically, serum potassium levels during long-term monitoring were independently associated with mortality in patients with heart failure. Likewise, persistence of abnormal potassium levels was linked to a higher risk of death in comparison with patients who maintained or returned to normal values.
Quality of care is under threat, and services “straining at the seams,” warns CQC
Authors: Gareth Iacobucci
Journal: BMJ (2017)

The quality of health and care services in England is holding up but looks increasingly precarious in a system that is “straining at the seams,” the Care Quality Commission has warned.

In its annual State of Care report for 2017 the regulator said that most health and care providers in England were continuing to provide good quality care, thanks to the hard work and dedication of staff and leaders.1 But it warned that the challenges associated with caring for an ageing population with increasingly complex medical needs had left the system struggling, with an estimated one in eight older people not getting the help they …
Analysis of liquid biopsies from metastatic colorectal carcinoma (mCRC) patients (pts) enrolled in the CAPRI GOIM clinical trial
Authors: N. Normanno, R. Esposito Abate, M. Lambiase, L. Forgione, C. Cardone, A. Iannaccone, A. Sacco, A.M. Rachiglio, E. Martinelli, D. Rizzi, S. Pisconti, G. Cartenì, R. Bordonaro, T. Troiani, F. Giuliani, S. Leo, S. Romito, A. Rinaldi, E. Maiello, F. Ciardiello
Journal: Annals of Oncology (2017)
Abstracts 801 to 1071
Authors: Edward Carter, Justin Pitman, Walter Jung, Alan Fischman, Ronald Tompkins, Julie In, Sai Ramnarayanan, Pamela Tuma, Peter Walbrun, Claus Hellerbrand, Thomas Weiss, Susanne Netter, Erwin Gaebele, Marcus Muehlbauer, Reiner Wiest, Juergen Schoelmerich, Matthias Froh, Susanne Keiding, Susanne Lausten, Simon Buus, Hendrik Vilstrup, Stellate Cells, Li Lei, Ji-Yao Wang, Jiang Wei, Peng Zhang, Hong Ma, Liting Wang, Jidong Jia, Nobuyuki Takaoka, Hidenori Shiraha
Journal: Hepatology (2006)

Liver injury is accompanied by replication and apoptosis, molecular processes which remove and replace the damaged cells.MRI and CT can detect structural abnormalities in the liver but cannot differentiate abscesses from metabolically active lesions.Likewise, it is difficult to differentiate between metabolism and replication in the liver using PET and FDG or FLT.Recently, radiolabeled FIAU (2-fluro-2-deoxy-1 beta-D-arabinofuranosyl-5iodouracil) has been examined by a number of groups for detection of replication of tumors in various animal models.Likewise, radiolabeled annexin has been used to detect the development of apoptosis in patients and animal models.In the present study, we examined the hepatic uptake of I125 FIAU or Tc99m annexin in mice subjected to CCl4 acute liver damage.Methods: Mice (8 in each group)(CD-1, Charles River, Wilmington, MA, 28 grams) were injected intraperitoneally with CCl4 (3 mL/kg, 2 mL/5 mL mineral oil)or mineral oil.48 hrs later the mice were injected in the tail vein with I125 FIAU (5 microcurie/mouse).Eighteen hours later the mice were sacrificed by carbon dioxide anesthesia, the liver removed and counted or the mice were anesthetized and subjected to planar imaging.Another group of mice were injected in the tail vein with Tc99m annexin or Tc99m labeled albumin (5 microcurie/mouse) 48 hrs after the CCl4 or mineral oil.One hour later the mice were subjected to planar imaging.A third group mice were treated with the CCl4 or mineral oil and liver tissue taken for standard histological analysis 48 hrs afterwards.Results: 48 hrs after injection, the CCl4 caused an 8-fold increase in the uptake of the I125 FIAU compared to the sham controls.Planar image analysis on these mice showed a demonstrable difference in the uptake of the radioactivity in the CCl4 treated mice compared to the controls.The uptake of radioactive annexin was greater in the CCl4 treated mouse liver than the control at this same time point, as measured by tissue counts or planar imaging.This change in Tc99m annexin did not appear to be related to changes in permeability since similar changes were not observed using Tc99m albumin injected into the CCl4 treated mice.The changes in the livers detected with the radioisotopes correlated to the histological analysis of the liver tissue, which demonstrated both replication and apoptosis in the CCl4 treated mouse livers.Conclusion: Radiolabeled FIAU and annexin may be useful in the detection of hepatic regeneration and replication, and as such may prove useful for imaging hepatocellular carcinoma.
ALK fusion variants detection by targeted RNA-next generation sequencing and clinical responses to crizotinib in ALK-positive non-small cell lung cancer
Authors: A. Mc Leer, M. Duruisseaux, J. Pinsolle, S. Dubourg, J. Mondet, M. Phillips-Houlbracq, N. Magnat, J. Fauré, A. Chatagnon, F. de Fraipont, M. Giaj Levra, A.C. Toffart, G. Ferretti, E. Brambilla, P. Hainaut, D. Moro-Sibilot, S. Lantuéjoul
Journal: Annals of Oncology (2017)
La vaccinazione contro la pertosse in Europa - la situazione alla fine del 1999
Authors: H Therre, S Baron
Journal: Eurosurveillance (2000)

La storia della pertosse nei paesi europei ha dimostrato con chiarezza che la vaccinazione diminuisce la morbosita associata alla malattia. I vaccini a cellule intere inattivati (wP - whole cell Pertussis) sono stati utilizzati nell'ambito campagne vaccinali di alcune nazioni per oltre 30 anni ma la presenza di reazioni avverse, soprattutto nei bambini con eta maggiore, ha destato preoccupazione. Dal 1970, allo scopo di migliorare i vaccini acellulari contro la pertosse, sono stati compiuti sforzi considerevoli per identificare i principali fattori di virulenza di Bordetella pertussis. Questi fattori sono la tossina della pertosse (pertussis toxin - PT), responsabile della maggior parte degli effetti tossici provocati dal batterio e i fattori di adesione, come l'emoagglutinina filamentosa (filamentous haemagglutinin - FHA), la pertactina (pertactin - PRN) e gli agglutinogeni fimbriali (fimbrial agglutinogens - AG). All'inizio, in Giappone, nel 1981, sono stati registrati vaccini acellulari semplici per bambini di due anni d'eta o piu grandi (1) e, quindi, sono stati associati ai tossoidi della difterite e del tetano (Diphtheria Tetanus and acellular Pertussis - DTaP).
Characterization of KCNK9 in The Cancer Genome Atlas breast cancer dataset.
Authors: Keith A. Dookeran, Maria Argos, Jacob K Kresovich, Garth H Rauscher
Journal: Journal of Clinical Oncology (2015)

1086 Background: Background: KCNK9 is a maternally imprinted and functionally mono-allelic 2-pore domain K+ channel proto-oncogene. It has been posited that loss of KCNK9 methylation (LOM) is associated with more aggressive triple negative (TN) phenotype breast cancer. Epidemiologic data characterizing KCNK9 is sparse and was the rationale for this study. Methods: Publically available breast cancer data from The Cancer Genome Atlas on clinical factors and KCNK9 gene methylation (HM450 beta values), amplification (putative copy-number alterations (CNA) from GISTIC), and mRNA expression Z-scores (RSEM) was examined in 818 women. Multivariable (MV) logistic regression models with model-based standardization were used to estimate risk ratios (RRs) with 95% confidence intervals (CIs). Results: Overall, KCNK9 gene amplification was more common than deletion (58% vs. 6%, respectively). Bivariate results for KCNK9 LOM (highest tertile loss vs. others), gene amplification (CNA gain vs. normal), and mRNA expression (highest tertile vs. others) are provided in the table below. Median overall survival for women with gain was 103 vs. 140 months (log-rank test, p= 0.011), and 96 vs. 130 months for higher vs. lower expression (p=0.014), but was not different for LOM. Conclusions: KCNK9 gene LOM, amplification and higher mRNA expression occur more frequently in black women, and ER/PR-negative and TN disease, and amplification and expression are associated with worse survival outcome. KCNK9 Characteristic LOM Amplification mRNA expression RR 95% CI p RR 95% CI p RR 95% CI P Age at diagnosis (<50/50+) 1.21 0.94-1.56 0.148 1.01 0.81-1.27 0.902 1.25 1.01-1.55 0.044 Stage (1-2A/2B-4) 0.88 0.74-1.04 0.131 1.03 0.89-1.19 0.676 0.99 0.86-1.14 0.895 ER/PR status (-/+) 7.52 5.02-11.28 <0.001 2.54 1.79-3.61 <0.001 2.35 1.83-3.02 <0.001 HER2 status (+/-) 0.71 0.47-1.09 0.113 1.35 0.99-1.83 0.053 0.92 0.69-1.22 0.547 TN status (+/-) 9.96 5.9-16.82 <0.001 2.94 1.88-4.59 <0.001 2.87 2.09-3.92 <0.001 Race (black/white) 1.98 1.3-3.01 0.001 1.94 1.23-3.06 0.003 1.37 0.95-1.99 0.096 Ethnicity (Hispanic/white) 1.44 0.72-2.89 0.300 0.82 0.41-1.66 0.586 1.03 0.5-2.09 0.945
HIV Care Outcomes Among Hispanics or Latinos with Diagnosed HIV Infection — United States, 2015
Authors: Zanetta Gant, Andre Dailey, Xiaohong Hu, Anna Satcher Johnson
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

National Latino AIDS Awareness Day is observed each year on October 15 to focus attention on the continuing disproportionate impact of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) on the Hispanic or Latino population in the United States.As of July 2015, the population of Hispanics or Latinos was estimated at 56.6 million, or approximately 18% of the U.S. population (1).However, in 2015, Hispanics or Latinos accounted for 24% of all new HIV diagnoses (2).At the end of 2014, an estimated 235,600 Hispanics or Latinos were living with HIV infection in the United States.In 38 jurisdictions with complete reporting of CD4 and viral load data, 75.4% were linked to care within 1 month of diagnosis, 70.2% received HIV medical care, and 58.2% were virally suppressed (3).National Latino AIDS Awareness Day is an opportunity to encourage increased HIV prevention activities, such as HIV testing, for Hispanics or Latinos.CDC supports testing, linkage to, and engagement in care and treatment, and a range of other efforts to reduce the risk for acquiring or transmitting HIV infection among Hispanics or Latinos.Additional information is available at https:// www.cdc.gov/Features/LatinoAIDSAwareness.
Comprehensive genomic profiling of metastatic and relapsed thyroid gland carcinomas is associated with tumor type and reveals new routes to targeted therapies
Authors: J.S. Ross, L.M. Gay, P. Vanden Borre, N. Almog, A.B. Schrock, J-A. Vergilio, J. Suh, S. Ramkissoon, E. Severson, S. Daniel, S.M. Ali, V.A. Miller, P.J. Stephens, J.A. Elvin, D. Bowles
Journal: Annals of Oncology (2017)
Elena Matsa
Authors: Pam Goldberg-Smith
Journal: Circulation Research (2017)

Yes, most of my time is spent in the lab, and I am currently working on two main projects, both dealing with precision medicine. 1One project 2,3 tries to figure out new treatments for people who are born with heart disease and have a mutation that causes the disease.This project is especially exciting since it's what I've been working on since my postdoctoral fellowship in the UK under my mentor Chris Denning.Right now, at Stanford, we have progressed to using nanomaterials to deliver the new treatment to the heart.The other project 4 relates to how our genetic makeup affects our response to medications.Some people are fine, but others may experience side effects when taking a drug, which can lead to heart complications.Fourteen percent of people who take antidiabetic medications have heart complications as a result of the medication rather than diabetes itself.In the lab, we take the blood cells from these people, create stem cells, and turn those into heart cells to see if they have the same proclivities. What LedYou to Study Cardiovascular Science, and What Brought You "Across the Pond" to the United States?How Hard Do You Work?I work only 10 to 12 hours a day now, which includes weekends; people not in academia can't believe it, but I'm used to Elena MatsaLighting Fires for Heart Disease
PIVOT-02: A phase 1/2, open-label, multicenter, dose escalation and dose expansion study of NKTR-214 and nivolumab in patients with select, locally advanced or metastatic solid tumor malignancies
Authors: A. Diab, M.E. Hurwitz, N. Tannir, C. Bernatchez, C. Haymaker, S.E. Bentebibel, B.D. Curti, M.K.K. Wong, I. Gergel, M. Tagliaferri, J. Zalevsky, U. Hoch, S. Aung, M. Imperiale, D. Cho, S.S. Tykodi, I. Puzanov, H. Kluger, P. Hwu, M. Sznol
Journal: Annals of Oncology (2017)
Evaluation of the Melanoma Tumor Burden Score (MTBS) in a real-world setting.
Authors: Michael Weichenthal, Gamze Senel, Marcus Both, Ilka Senkpiehl, Dragana Lekic, Katharina C. Kähler, Selma Ugurel, Ulrike M. Leiter, Peter Mohr, Axel Hauschild, Dirk Schadendorf
Journal: Journal of Clinical Oncology (2017)

9565 Background: Clinical cancer registration is increasingly important for healthcare delivery and outcome research in oncology. As compared to clinical trial data, information from clinical routine is often limited regarding the granularity and quality of measures for individual tumor load and distribution. Methods: In an effort to implement a robust and useful measure of tumor burden for patients with metastatic melanoma in a German national skin cancer registry (ADOReg) we evaluated the melanoma tumor burden score (MTBS), originally developed for analyzing chemotherapy data in melanoma patients. The MTBS contains a simple categorization of size, number an distribution of metastatic lesions in individual patients. It is aimed at being used on routine radiologic report allowing for a certain level of uncertainty and imprecise quantification of metastatic lesions. Basically, the lesions are categorized per affected organ with respect to number (solitary, few, multiple) and size (≤1cm, &gt;1- 5cm, &gt;5cm). For evaluation of prognostic significance the summary score was calculated and included in univariate and multivariate survival analysis. We performed extensive sensitivity analyses for a variety of different model settings. Results: In the primary analysis set we re-evaluated 898 radiologic reports in a total of 235 various chemotherapies in n=128 stage IV melanoma patients. The confirmatory data sets consisted of n=384 stage IV melanoma patients with various treatments including chemotherapy, BRAF inhibitor treatment, and immune checkpoint blockade. MTBS categorization could be applied on routine radiologic reports in the majority of cases (95.7 %). In a multivariate model MTBS remained significantly correlated with outcome when adjusted for age, sex, LDH, and number of metastatic sites. Moreover, change in MTBS correlated to a formal response evaluation according to RECIST. Conclusions: The MTBS appears to be a promising tool for meaninful quantification of metastatic tumor load in metastatic melanoma for real life data collection like in clinical cancer registries. [Table: see text]
Association of Pediatric Medical Emergency Teams With Hospital Mortality
Authors: Shelby Kutty, Philip G. Jones, Quentin Karels, Navya Joseph, John A. Spertus, Paul S. Chan
Journal: Circulation (2017)

Implementation of medical emergency teams has been identified as a potential strategy to reduce hospital deaths, because these teams respond to patients with acute physiological decline in an effort to prevent in-hospital cardiac arrest. However, prior studies of the association between medical emergency teams and hospital mortality have been limited and typically have not accounted for preimplementation mortality trends.Within the Pediatric Health Information System for freestanding pediatric hospitals, annual risk-adjusted mortality rates were calculated for sites between 2000 and 2015. A random slopes interrupted time series analysis then examined whether implementation of a medical emergency team was associated with lower-than-expected mortality rates based on preimplementation trends.Across 38 pediatric hospitals, mean annual hospital admission volume was 15 854 (range, 6684-33 024), and there were a total of 1 659 059 hospitalizations preimplementation and 4 392 392 hospitalizations postimplementation. Before medical emergency team implementation, hospital mortality decreased by 6.0% annually (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.92-0.96) across all hospitals. After medical emergency team implementation, hospital mortality continued to decrease by 6% annually (OR, 0.94; 95% CI, 0.93-0.95), with no deepening of the mortality slope (ie, not lower OR) in comparison with the preimplementation trend, for the overall cohort (P=0.98) or when analyzed separately within each of the 38 study hospitals. Five years after medical emergency team implementation across study sites, there was no difference between predicted (hospital mean of 6.18 deaths per 1000 admissions based on preimplementation trends) and actual mortality rates (hospital mean of 6.48 deaths per 1000 admissions; P=0.57).Implementation of medical emergency teams in a large sample of pediatric hospitals in the United States was not associated with a reduction in hospital mortality beyond existing preimplementation trends.
P57-mediated autophagy promotes the efficacy of EGFR inhibitors in hepatocellular carcinoma
Authors: Q. Li, L. Jing, T. Wu, Y. Wang, T.H. Huang, L.X. Huang, J. Wang, S.Z. Yu, Tao Tian, Z.P. Ruan, X. Liang, K.J. Nan, H. Guo
Journal: Annals of Oncology (2017)
Event free survival at 24 months: A new endpoint in diffuse large B-cell lymphoma
Authors: B. Cantos, J.C. Sanchez, V. Calvo de Juan, M. Mendez Garcia, C. Maximiano Alonso, D. Perez Callejo, F.F. Franco, L. Gutierrez Sanz, A. Gonzaga López, B. Nuñez, M. Provencio Pulla
Journal: Annals of Oncology (2017)
High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice
Authors: Sarah E. Heywood, Adele L. Richart, Darren C. Henstridge, Karen Alt, Helen Kiriazis, Claire Zammit, Andrew L. Carey, Helene L. Kammoun, Lea M. Delbridge, Medini Reddy, Yi-Ching Chen, Xiao-Jun Du, Christoph E. Hagemeyer, Mark A. Febbraio, Andrew L. Siebel, Bronwyn A. Kingwell
Journal: Science Translational Medicine (2017)

One dose of rHDL after myocardial ischemia increases both cardiac glucose uptake and heart function in healthy and insulin-resistant mice.
A prospective multicenter, phase II trial (NAC-GA trial) to evaluate the effect of neoadjuvant nab-paclitaxel plus gemcitabine therapy on overall survival in patients with borderline resectable pancreatic cancer
Authors: K-I. Okada, T. Shimokawa, S. Hirono, M. Kawai, M. Miyazawa, Y. Kitahata, H. Yamaue
Journal: Annals of Oncology (2017)
Prognostic impact of BRAF and KRAS mutations according to the consensus molecular subtypes of colorectal cancer
Authors: J. Smeby, A. Sveen, C.H. Bergsland, J. Bruun, M. Merok, S.A. Danielsen, M. Hektoen, M. Eknæs, I.A. Eilertsen, M. Grønlie Guren, A. Nesbakken, R.A. Lothe
Journal: Annals of Oncology (2017)
Sarampión en Alemania
Authors: E Gericke, Gernot Rasch, A Tischer, S Santibanez
Journal: Eurosurveillance (1997)

El 19 y 20 de noviembre de 1.996, se llevo a cabo en Copenhague una reunion de expertos con el objeto de analizar la erradicacion del sarampion en Europa. Los paises europeos se clasificaron en cuatro categorias diferentes en funcion de un estudio recientemente realizado por la Oficina Regional de Europa de la OMS (1). Alemania esta incluida en el tercer grupo (tabla 1), formado por paises con sarampion endemico, brotes importantes y olas epidemicas, baja cobertura de vacunacion y donde no se realiza una labor de vigilancia sistematica.
Abstract 245: Cxcl12 Chemokine Signaling Regulates Synchronous Development of Coronary Vessels and Myocardium
Authors: Ching-Ling Lien, Michael R Harrison
Journal: Circulation Research (2016)

Introduction: The coronary vasculature plays critical roles in heart functions. Coronary heart disease is a major cause of myocardial infarction and heart failure, which continues to be the leading cause of mortality. However, the mechanisms underlying coronary vessel development and myocardial vascularization are not fully understood. Furthermore, it is not known if myocardial developmental defects caused by lack of vascularization will lead to decreased regenerative capacity of the adult heart. Hypothesis: Synchronous development with coronary vessels is essential for normal morphogenesis and regenerative capacity of the myocardium of zebrafish heart. Methods and Results: Using transgenic reporter fish lines, we observed that during zebrafish heart development, coronary vessels form a close association with a specific subpopulation of cortical cardiomyocytes marked by the transcription factor Gata4. When gata4+ cardiomyocytes emerge onto the surface of the juvenile zebrafish hearts, they follow the tracks of coronary endothelial cells. We previously showed that cxcr4a mutant zebrafish fail to form a vascular network, whereas ectopic expression of Cxcl12b ligand induces coronary vessel formation. In cxcr4a mutant hearts, gata4+ cardiomyocytes fail to associate with coronary vessels. Importantly, cxcr4a mutant zebrafish fail to undergo heart regeneration following injury. Gene expression analysis using RNAseq was performed to dissect the molecular mechanisms underlying synchronous development of coronary vessels and gata4+ cardiomyocytes. Conclusion: Our results suggest that Cxcl12/Cxcr4 chemokine signaling has an essential role in directing cardiomyocyte migration guided by endothelial cells. Poorly developed vasculature in cxcr4a mutants likely underlies defects in myocardial development and decreased regenerative potential of zebrafish hearts.