tbuckley/cabot-search huggingface dataset:
CYP2C19 Genotype-Guided Dosing and Voriconazole Concentrations in Hematopoietic Stem Cell Transplant Patients (HSCT) Receiving Antifungal Prophylaxis
Authors: Jai N Patel, Myra M Robinson, Issam Hamadeh, Zainab Shahid, James T Symanowski, Dragos Plesca, Margaret Croom, Jigar Trivedi, Nury M. Steuerwald, Belinda R. Avalos, Edward A. Copelan
Journal: Blood (2016)
強化された抗腫瘍効能を有するNd~3+増感アップコンバージョン発光を利用した完全による808nm光誘起およびヒアルロン酸標的二重光増感剤ナノプラットフォーム【Powered by NICT】
Authors: Hou Zhiyao, Deng Kerong, Li Chunxia, Deng Xiaoran, Lian Hongzhou, Cheng Ziyong, Jin Dayong, Lin Jun
Journal: Biomaterials (2016)
トロポエラスチン被覆したPLLA PLGA足場は血管網形成を促進する【Powered by NICT】
Authors: Landau Shira, A Szklanny Ariel, C Yeo Giselle, Shandalov Yulia, Kosobrodova Elena, S Weiss Anthony, Levenberg Shulamit
Journal: Biomaterials (2017)
Air Pollution and Risk of Parkinson’s Disease in a Large Prospective Study of Men
Authors: Natalia Palacios, Kathryn C. Fitzgerald, Jaime E. Hart, Marc Weisskopf, Michael A. Schwarzschild, Alberto Ascherio, Francine Laden
Journal: Environmental Health Perspectives (2017)

Background: Exposure to air pollution has been implicated in a number of adverse health outcomes, and the effect of particulate matter (PM) on the brain is beginning to be recognized. Objectives: We aimed to examine whether exposure to PM air pollution is related to risk of Parkinson's disease (PD) in the Health Professionals Follow-up Study (HPFS), a large prospective cohort of U.S. men. Methods: We prospectively followed 50,352 men in the HPFS, a large prospective cohort of U.S. men, and identified 550 incident PD cases. Cumulative average exposure to various size fractions of PM [PM10 (≤10μm microns in diameter), PM2.5 (≤2.5μm in diameter), and PM2.5–10 (between 2.5 and 10μm in diameter)] up to 2 years before the onset of PD was estimated using a spatiotemporal model by linking each participant's place of residence throughout the study with location-specific PM levels. We used multivariable Cox proportional hazards models to independently estimate the risk of PD associated with each size fraction of PM. Results: In models adjusted for age, smoking, region, and population density, we did not observe statistically significant associations between exposure to PM and PD risk. In analyses considering cumulative average PM exposure, the comparing the top to the bottom quintile of PM exposure was 0.85 [95% confidence interval (CI): (0.63, 1.15)] for PM10, 0.97 [95% CI: (0.72, 1.32)] for PM2.5, and 0.88 [95% CI: (0.64, 1.22)] for hazard ratio (HR) PM2.5–10. The results did not change markedly when restricted to men who did not move during the study or when stratified by smoking status or population density. Conclusions: In this study, we found no evidence that exposure to air pollution is a risk factor for PD in men. https://doi.org/10.1289/EHP259
Efficacy of a video-based psychological intervention for cancer-related insomnia: Results of a randomized controlled trial.
Authors: Josée Savard, Hans Ivers, Marie-Hélène Savard, Charles Morin
Journal: Journal of Clinical Oncology (2014)

9530 Background: Cognitive-behavioral therapy (CBT) is considered the treatment of choice for insomnia but is only rarely offered to cancer patients. It is therefore important to develop treatment formats that would maximize its accessibility in routine care. This study aimed at comparing the short- and long-term efficacy of two different formats of CBT for insomnia, a professionally-administered format (PCBT-I) and a video-based format (VCBT-I), to that of a no-treatment control condition (CTL). Methods: A sample of 242 women with breast cancer was randomized to: 1) video-based CBT-I (VCBT-I; n=80), composed of a 60-min animated video + 6 booklets; 2) professionally-administered CBT-I (PCBT-I; n=81), composed of 6 weekly sessions of 50 min; and 3) no treatment (n=81). The main study variables, collected at pre- and post-treatment, as well as at 3-, 6-, and 12-month follow-ups, were the Insomnia Severity Index (ISI) total score and sleep parameters derived from a daily sleep diary: sleep onset latency (SOL), wake after sleep onset (WASO), early morning awakenings (EMA), total wake time (TWT), and sleep efficiency (SE). Results: Mixed models analyses revealed that both PCBT-I and VCBT-I were associated with significantly greater sleep improvements, assessed subjectively, as compared to CTL at post-treatment. However, compared to VCBT-I, PCBT-I was associated with significantly greater improvements of ISI scores and EMA, depression, fatigue and dysfunctional beliefs about sleep. The remission rate of insomnia was significantly greater in PCBT-I as compared to VCBT-I (71.3% vs. 44.3%, p<.005).Except for WASO, no significant differences were found between the post-treatment and follow-up assessments in PCBT-I and VCBT-I groups (time effects). Between group differences at 3-, 6-, and 12-month follow-ups revealed larger treatment effects in PCBT-I when compared to CTL alone (ISI, WASO, EMA, SE) or both VCBT-I and CTL (SOL, TWT). Conclusions: Both short-term and long-term findings show that our video-based CBT-I is a most valuable alternative but that face-to-face sessions remain the optimal format for administering efficaciously CBT for insomnia in cancer patients. Clinical trial information: NCT00674830.
Researches on Temperature in Phthisis and Some Other Diseases: With Remarks on the General Value of Thermometric Observations in Diseased Conditions
Authors: A. T. H. Waters
Journal: BMJ (1879)

supple end that will bend at once before the obstacle, he makes an in- strument that bends slowly along a good part of its length, and so fails to accomplish the intention of the supple end, which is to change the direction of the point quickly, that it may slip by an obstruction and pass on.The " olive" or swell at the tip also is often made much too large; it should never approach the thickness of the stem, but be just sufficient to remove all sharpness from the point.The Frencn tapering bougie can be made to preserve any desired curve against a moderate strain by running down the interior of the bougie a leaden wire, or by filling it with shot.In this way, they are almost as useful as English bougies in the cases where a fixed curve is desired.When compared with each other, the following are the chief charac- teristics of rigid and flexible instruments.Rigid instruments are far more difficult to pass, more capable of injuring the patient, and, unless passed with proper skill, more painful to him.On the other hand, they are more durable, can be easily kept in good condition in hot cli- mates, can be made more smooth and, being rigid, their points can be guided by the hand past pouches and other obstructions.Of flexible instruments, the great advantage is their suppleness.This enables them to accommodate themselves to the urethra without strain; but, as their points cannot be easily directed away from an obstruction or false passage, they often slip where a rigid sound readily gains the bladder. RESEARCHES
Abnormal Expression of the Chemokine (C-C Motif) Ligand 17 Gene in Adult B-Cell Acute Lymphoblastic Leukemia
Authors: Yong-Huai Feng, Wei-Min Wang, Wen-Yi Lu, Shu-Juan Wang, Qiu-Mei Yao, Jiao Zhou, Jia-Min Zhang, Xiao-Jun Huan, Kai-Yan Liu, Guo-Rui Ruan
Journal: Blood (2016)
A Phase II Trial of Neoadjuvant MK-2206, an AKT Inhibitor, with Anastrozole in Clinical Stage II or III<i>PIK3CA</i>-Mutant ER-Positive and HER2-Negative Breast Cancer
Authors: Cynthia X. Ma, Vera Suman, Matthew P. Goetz, Donald Northfelt, Mark E. Burkard, Foluso Ademuyiwa, Michael Naughton, Julie Margenthaler, Rebecca Aft, Richard Gray, Amye Tevaarwerk, Lee Wilke, Tufia Haddad, Timothy Moynihan, Charles Loprinzi, Tina Hieken, Erica K. Barnell, Zachary L. Skidmore, Yan-Yang Feng, Kilannin Krysiak, Jeremy Hoog, Zhanfang Guo, Leslie Nehring, Kari B. Wisinski, Elaine Mardis, Ian S. Hagemann, Kiran Vij, Souzan Sanati, Hussam Al-Kateb, Obi L. Griffith, Malachi Griffith, Laurence Doyle, Charles Erlichman, Matthew J. Ellis
Journal: Clinical Cancer Research (2017)

Abstract Purpose: Hyperactivation of AKT is common and associated with endocrine resistance in estrogen receptor–positive (ER+) breast cancer. The allosteric pan-AKT inhibitor MK-2206 induced apoptosis in PIK3CA-mutant ER+ breast cancer under estrogen-deprived condition in preclinical studies. This neoadjuvant phase II trial was therefore conducted to test the hypothesis that adding MK-2206 to anastrozole induces pathologic complete response (pCR) in PIK3CA mutant ER+ breast cancer. Experimental Design: Potential eligible patients with clinical stage II/III ER+/HER2− breast cancer were preregistered and received anastrozole (goserelin if premenopausal) for 28 days in cycle 0 pending tumor PIK3CA sequencing. Patients positive for PIK3CA mutation in the tumor were eligible to start MK-2206 (150 mg orally weekly, with prophylactic prednisone) on cycle 1 day 2 (C1D2) and to receive a maximum of four 28-day cycles of combination therapy before surgery. Serial biopsies were collected at preregistration, C1D1 and C1D17. Results: Fifty-one patients preregistered and 16 of 22 with PIK3CA-mutant tumors received study drug. Three patients went off study due to C1D17 Ki67 &amp;gt;10% (n = 2) and toxicity (n = 1). Thirteen patients completed neoadjuvant therapy followed by surgery. No pCRs were observed. Rash was common. MK-2206 did not further suppress cell proliferation and did not induce apoptosis on C1D17 biopsies. Although AKT phosphorylation was reduced, PRAS40 phosphorylation at C1D17 after MK-2206 persisted. One patient acquired an ESR1 mutation at surgery. Conclusions: MK-2206 is unlikely to add to the efficacy of anastrozole alone in PIK3CA-mutant ER+ breast cancer and should not be studied further in the target patient population. Clin Cancer Res; 23(22); 6823–32. ©2017 AACR.
No evidence for major adverse events related to suspicion of Ebola in France, 2014–2015
Authors: M. Lachâtre, M. Méchain, M. Etienne, P. Gautret, S. Matheron, M. Nahon, H. Coignard-Biehler, D. Malvy, X. Duval, P. Tattevin
Journal: Clinical Microbiology and Infection (2017)
動脈再狭窄の標的治療のための炎症性微小環境に応答するナノ粒子【Powered by NICT】
Authors: Feng Shibin, Hu Ying, Peng Song, Han Songling, Tao Hui, Zhang Qixiong, Xu Xiaoqiu, Zhang Jianxiang, Hu Houyuan
Journal: Biomaterials (2016)
Peri-orificial rash in an infant
Authors: Hui Min Liew, Jin Ho Chong
Journal: BMJ (2017)

A 6 month old girl was brought to the paediatric dermatology outpatient clinic with a rash, irritability, and poor weight gain for two months. She was born at 32 weeks’ gestation with intrauterine growth restriction as a result of placental insufficiency. She was exclusively breastfed. There was no family history of skin disorders. On examination, she had scaly erythematous plaques around her eyes, nose, mouth, ears, and neck (fig 1⇓). Fig 1 Scaly erythematous plaques around the eyes, nostril, mouth, ears, and neck She had been recently prescribed mild topical corticosteroids to treat presumed atopic dermatitis, but there had been no improvement. Skin swab and scraping for bacterial and fungal microscopy and culture were taken. The serum zinc level of the child and her mother, and the full blood count and liver function tests for the child were obtained.
A novel fibroblast growth factor-1 ligand with reduced heparin binding protects the heart against ischemia-reperfusion injury in the presence of heparin co-administration
Authors: Chahua Huang, Yang Liu, Andrew Beenken, Lin Jiang, Xiang Gao, Zhifeng Huang, Anna Hsu, Garrett J. Gross, Yi-Gang Wang, Moosa Mohammadi, Jo El J. Schultz
Journal: Cardiovascular Research (2017)

Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI). The impact of heparin, the standard of care for MI patients entering the emergency room, on cardioprotective effects of FGF1 is unknown, however.
セラミド,スフィンゴシン1‐りん酸及びセラミド1‐りん酸による炎症反応の制御【Powered by NICT】
Authors: Gomez-Munoz Antonio, Presa Natalia, Gomez-Larrauri Ana, Rivera Io-Guane, Trueba Miguel, Ordonez Marta
Journal: Progress in Lipid Research (2016)
Co-purification and analysis of global gene expression and allele-specific copy number from a single microdissected FFPE sample in pancreatic ductal adenocarcinoma.
Authors: Eric Collisson, Amrita Ray, Grace Kim, Janine Cooc, Rachel Hajnal, Yuker Wang, Malek Faham, Paul Spellman, Kathleen Danenberg, Margaret Tempero, Joe Gray
Journal: Cancer Research (2008)

4964   Background: Unlike numerous other tumor types, little is known about the expression and copy number patterns of pancreatic ductal adenocarcinoma (PDA) primary tumors. This is due in large part to the difficulty obtaining tissue from this retroperitoneal organ, and the poor quality of nucleic acids obtained. Severe desmoplasia leads to stromal contamination and the extreme autodigestive properties often leads to degraded nucleic acids. Nevertheless, robust and accurate molecular measurements are essential in generating predictive and prognostic biomarkers in this disease.  Methods: We selected FFPE blocks from 20 Whipple resections performed for PDA at UCSF. Microdissection was performed. Genomic DNA and total RNA were isolated using proprietary technology at Response Genetics. After amplification cRNA was hybridized to Affymetric Hu133Plus2 chips. Co-extracted genomic DNA (~70ng) was subjected to genome wide allele-specific copy number analysis using molecular inversion probe (MIP) technology. We assessed the quality of MIP data by the median proportion of overlapping clones in neighboring segments. We compared this to similar datasets from 1) cancer cell lines and 2) non-microdissected frozen primary tumors. We also analyzed the correlation between gene copy number and expression to identify dosage effects in co-extracted tissues.  Results: Expression and copy number data were successfully obtained in 20 and 19 samples respectively. The quality assessment of the MIPs showed that only 15% of all MIPs overlap with neighboring clones, whereas we observed 22% overlap for non microdissected tumors. A strong influence of copy number on mRNA expression was also observed.  Conclusion: Primary tumor samples are a valuable, limited resource. We show here that genomic DNA and mRNA can be successfully and consistently co-isolated from a single microdissected FFPE sample in PDA and analyzed for global expression and allele specific copy number. Gene expression reflects copy number as in samples extracted separately. FFPE MIP data compared favorably to non-microdissected, frozen tumor samples. This work maximizes data from rare samples and has implications for the personalization of treatment, prognosis studies and adjuvant clinical trial tissue analysis. Future work will focus on needle-based biopsy procedures.
Association of White Matter Structure With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder
Authors: Yuta Aoki, Yuliya N. Yoncheva, Bosi Chen, Tanmay Nath, Dillon Sharp, Mariana Lazar, Pablo Velasco, Michael P. Milham, Adriana Di Martino
Journal: JAMA Psychiatry (2017)

Clinical overlap between autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) is increasingly appreciated, but the underlying brain mechanisms remain unknown to date.To examine associations between white matter organization and 2 commonly co-occurring neurodevelopmental conditions, ASD and ADHD, through both categorical and dimensional approaches.This investigation was a cross-sectional diffusion tensor imaging (DTI) study at an outpatient academic clinical and research center, the Department of Child and Adolescent Psychiatry at New York University Langone Medical Center. Participants were children with ASD, children with ADHD, or typically developing children. Data collection was ongoing from December 2008 to October 2015.The primary measure was voxelwise fractional anisotropy (FA) analyzed via tract-based spatial statistics. Additional voxelwise DTI metrics included radial diffusivity (RD), mean diffusivity (MD), axial diffusivity (AD), and mode of anisotropy (MA).This cross-sectional DTI study analyzed data from 174 children (age range, 6.0-12.9 years), selected from a larger sample after quality assurance to be group matched on age and sex. After quality control, the study analyzed data from 69 children with ASD (mean [SD] age, 8.9 [1.7] years; 62 male), 55 children with ADHD (mean [SD] age, 9.5 [1.5] years; 41 male), and 50 typically developing children (mean [SD] age, 9.4 [1.5] years; 38 male). Categorical analyses revealed a significant influence of ASD diagnosis on several DTI metrics (FA, MD, RD, and AD), primarily in the corpus callosum. For example, FA analyses identified a cluster of 4179 voxels (TFCE FEW corrected P < .05) in posterior portions of the corpus callosum. Dimensional analyses revealed associations between ASD severity and FA, RD, and MD in more extended portions of the corpus callosum and beyond (eg, corona radiata and inferior longitudinal fasciculus) across all individuals, regardless of diagnosis. For example, FA analyses revealed clusters overall encompassing 12121 voxels (TFCE FWE corrected P < .05) with a significant association with parent ratings in the social responsiveness scale. Similar results were evident using an independent measure of ASD traits (ie, children communication checklist, second edition). Total severity of ADHD-traits was not significantly related to DTI metrics but inattention scores were related to AD in corpus callosum in a cluster sized 716 voxels. All these findings were robust to algorithmic correction of motion artifacts with the DTIPrep software.Dimensional analyses provided a more complete picture of associations between ASD traits and inattention and indexes of white matter organization, particularly in the corpus callosum. This transdiagnostic approach can reveal dimensional relationships linking white matter structure to neurodevelopmental symptoms.
Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis
Authors: Andrea Gimenez, Karin Storrer, Lilian Kuranishi, Maria Raquel Soares, Rimarcs Gomes Ferreira, Carlos A C Pereira
Journal: Thorax (2017)

The predictive value of the decline in FVC by ≥10% on survival in patients with fibrotic hypersensitivity pneumonitis is unknown. Of 112 patients included, 66 (59%) had surgical lung biopsies. Patients with ≥10% decline in predicted FVC after 6–12 months had a significantly increased risk of all-cause mortality (median survival 53 months, 95% CI 37 to 69 vs 139 months, 95% CI 66 to 212 months, p=0.007). On multivariate analysis remained associated with increasing mortality: decline in FVC by ≥10% (HR 4.13, 95% CI 1.96 to 8.70, p=0.005), lower FVC% (HR 1.03, 95% CI 1.01 to 1.05, p=0.003) and with decreasing mortality improvement with antigen avoidance (HR 0.18, 95% CI 0.04 to 0.77, p=0.021).
Reply
Authors: James M. Gwinnutt, Deborah P. M. Symmons, Mark Lunt, Suzanne M. M. Verstappen
Journal: Arthritis & Rheumatology (2017)

We thank Dr Crowson for her interest in our study and for her comment.(1,2) Immortal time bias is an important issue in observational research and can lead to large biases and misinterpretation of results. However, we would argue that in this instance, the bias is not large and the clinical message from our analysis has not changed.

Immortal time leads to important bias when a large proportion of follow-up time in the exposed group is considered ‘immortal’.

This article is protected by copyright. All rights reserved.
OP0150 Paradoxical effect of biological dmards in rheumatoid arthritis patients with overweight and obesity: less often clinical remission, but also less radiological damage
Authors: AV de Jonge, MM ter Wee, IE Bultink, WF Lems
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> The relationship between treatment with biological disease-modifying antirheumatic drugs (DMARDs), including TNF-blocking agents, and disease activity in overweight and obese rheumatoid arthritis (RA) patients has not been clarified yet. <h3>Objectives</h3> The aim of this review is to assess the effect of overweight/obesity on the therapeutic efficacy of these drugs. Secondly, we aimed to assess the influence of overweight/obesity on the occurrence of joint destruction. <h3>Methods</h3> A systematic review of all articles published on these subjects using PubMed and EMBASE was executed. For the first research question, studies were eligible when focused on the clinical efficacy of biological DMARDs only in overweight/obese RA patients versus patients with normal body weight. For the second research question studies were eligible when questioning the relation between overweight and joint destruction in patients with RA. Overweight and obesity were defined according to the following body mass index (BMI) categories; BMI &lt;20 kg/m<sup>2</sup> for underweight, BMI 20–25 kg/m<sup>2</sup> for normal weight, BMI 25–30 kg/m<sup>2</sup> and BMI &gt;30 kg/m<sup>2</sup> for overweight. <h3>Results</h3> A total of 6782 articles were found, of which 12 were eligible for this review. A total of 3647 RA patients were treated with adalimumab, etanercept, infliximab, golimumab, or certolizumab pegol, or TNF blockers, rituximab, or tocilizumab. Ten studies used disease activity as outcome. In general, these studies showed that higher BMI is associated with poor response, based on either outcome or percentages on remission or improvement defined according to EULAR guidelines. In addition, four studies showed that higher BMI is also associated with higher Health Assessment Questionnaire (HAQ)-scores. Two articles (of which one article described the results of studies in two different RA cohorts) focused on the association between BMI and joint destruction. These articles showed that higher BMI values were associated with lower odds for having joint destruction. One study also showed that having a BMI &lt;20 kg/m<sup>2</sup> was associated with a higher odds ratio (OR =4.12) for joint destruction. <h3>Conclusions</h3> Higher BMI levels in RA patients treated with biological DMARDs are associated with reduced therapeutic efficacy as compared to RA patients with normal body composition. The unfavourable effect of body weight on disease activity was paralleled by a favourable, protective effect on joint destruction. This uncoupling is not fully elucidated yet, and should be further investigated. <h3>Disclosure of Interest</h3> None declared
Deficient Immune Response to Viral Infections in Children Predicts Later Asthma Persistence
Authors: Simonetta Baraldo, Marco Contoli, Matteo Bonato, Deborah Snijders, Davide Biondini, Erica Bazzan, Manuel G. Cosio, Angelo Barbato, Alberto Papi, Marina Saetta
Journal: American Journal of Respiratory and Critical Care Medicine (2017)