tbuckley/cabot-search huggingface dataset:
Effect of Neoadjuvant Chemoradiotherapy on Health-Related Quality of Life in Esophageal or Junctional Cancer: Results From the Randomized CROSS Trial
Authors: Bo Jan Noordman, Mathilde G.E. Verdam, Sjoerd M. Lagarde, Maarten C.C.M. Hulshof, Pieter van Hagen, Mark I. van Berge Henegouwen, Bas P.L. Wijnhoven, Hanneke W.M. van Laarhoven, Grard A.P. Nieuwenhuijzen, Geke A.P. Hospers, Johannes J. Bonenkamp, Miguel A. Cuesta, Reinoud J.B. Blaisse, Olivier R. Busch, Fiebo J.W. ten Kate, Geert-Jan M. Creemers, Cornelis J.A. Punt, John Th.M. Plukker, Henk M.W. Verheul, Ernst J. Spillenaar Bilgen, Herman van Dekken, Maurice J.C. van der Sangen, Tom Rozema, Katharina Biermann, Jannet C. Beukema, Anna H.M. Piet, Caroline M. van Rij, Janny G. Reinders, Hugo W. Tilanus, Ewout W. Steyerberg, Ate van der Gaast, Mirjam A.G. Sprangers, J. Jan B. van Lanschot
Journal: Journal of Clinical Oncology (2017)

Purpose To compare pre-agreed health-related quality of life (HRQOL) domains in patients with esophageal or junctional cancer who received neoadjuvant chemoradiotherapy (nCRT) followed by surgery or surgery alone. Secondary aims were to examine the effect of nCRT on HRQOL before surgery and the effect of surgery on HRQOL. Patients and Methods Patients were randomly assigned to nCRT (carboplatin plus paclitaxel with concurrent 41.4-Gy radiotherapy) followed by surgery or surgery alone. HRQOL was measured using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire–Core 30 (QLQ-C30) and –Oesophageal Cancer Module (QLQ-OES24) questionnaires pretreatment and at 3, 6, 9, and 12 months postoperatively. The nCRT group also received preoperative questionnaires. Physical functioning (PF; QLQ-C30) and eating problems (EA; QLQ-OES24) were chosen as predefined primary end points. Predefined secondary end points were global QOL (GQOL; QLQ-C30), fatigue (FA; QLQ-C30), and emotional problems (EM; QLQ-OES24). Results A total of 363 patients were analyzed. No statistically significant differences in postoperative HRQOL were found between treatment groups. In the nCRT group, PF, EA, GQOL, FA, and EM scores deteriorated 1 week after nCRT (Cohen’s d: −0.93, P &lt; .001; 0.47, P &lt; .001; −0.84, P &lt; .001; 1.45, P &lt; .001; and 0.32, P = .001, respectively). In both treatment groups, all end points declined 3 months postoperatively compared with baseline (Cohen’s d: −1.00, 0.33, −0.47, −0.34, and 0.33, respectively; all P &lt; .001), followed by a continuous gradual improvement. EA, GQOL, and EM were restored to baseline levels during follow-up, whereas PF and FA remained impaired 1 year postoperatively (Cohen’s d: 0.52 and −0.53, respectively; both P &lt; .001). Conclusion Although HRQOL declined during nCRT, no effect of nCRT was apparent on postoperative HRQOL compared with surgery alone. In addition to the improvement in survival, these findings support the view that nCRT according to the Chemoradiotherapy for Esophageal Cancer Followed by Surgery Study–regimen can be regarded as a standard of care.
Patient-reported priorities for survivorship care and experience discussing available services.
Authors: Julia Rabin, Katharine Quain, Nora Horick, Garrett Chinn, Allison McDonough, Areej El-Jawahri, Yen-Lin Chen, Belle De Rooij, Giselle Katiria Perez, Elyse Park, Jeffrey M. Peppercorn
Journal: Journal of Clinical Oncology (2017)

200 Background: Despite the recognized need for high quality survivorship care, barriers to identifying and addressing patients’ needs still remain. We sought to evaluate cancer survivor care priorities, awareness of available services, and factors associated with care and informational needs. Methods: A needs assessment survey was distributed to patients presenting for routine follow-up care in adult oncology clinics at the MGH Cancer Center between February and August of 2016. The survey assessed sociodemographic characteristics, and preferences for care and communication. Care priorities were selected from a list of options including open ended response. Discussion of supportive care services was assessed by the item “have any of your providers informed you about the types of supportive care services that are available to cancer patients" with response options of “yes,” “no” or “don’t know.” Results: Among 637 total respondents, 339 patients with early stage cancer completed the survey. The majority of participants were between 50-69 years old (54%), white (89%), female (64%), and college educated (80%). Breast (32%) and hematological malignancies (21%) were the most prevalent diagnoses. Commonly endorsed priorities for care included: emotional concerns related to cancer (40%), strategies to increase self-care (33%), and management of physical cancer symptoms (30%). Demographic and clinical factors associated with endorsing emotional concerns as a care priority included female gender, and moderate or greater levels of fatigue, depression, or anxiety (all p&lt; 0.01). Factors associated with endorsing management of physical cancer symptoms as a care priority included younger age, and moderate or greater levels of fatigue or depression (all p≤0.01). Despite these priorities for care, only 41% of patients reported receiving information from providers about available supportive care services. Conclusions: Cancer survivors’ preferences for emotional support and symptom management are strongly associated with self-reported depression and fatigue. Routine screening for these issues and improvement in communication regarding available services should be prioritized in survivorship care.
Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments
Authors: Anje Cauwels, Sandra Van Lint, Franciane Paul, Geneviève Garcin, Stefaan De Koker, Alexander Van Parys, Thomas Wueest, Sarah Gerlo, José Van der Heyden, Yann Bordat, Dominiek Catteeuw, Elke Rogge, Annick Verhee, Bart Vandekerckhove, Niko Kley, Gilles Uzé, Jan Tavernier
Journal: Cancer Research (2017)

An ideal generic cancer immunotherapy should mobilize the immune system to destroy tumor cells without harming healthy cells and remain active in case of recurrence. Furthermore, it should preferably not rely on tumor-specific surface markers, as these are only available in a limited set of malignancies. Despite approval for treatment of various cancers, clinical application of cytokines is still impeded by their multiple toxic side effects. Type I IFN has a long history in the treatment of cancer, but its multifaceted activity pattern and complex side effects prevent its clinical use. Here we develop AcTakines (Activity-on-Target cytokines), optimized (mutated) immunocytokines that are up to 1,000-fold more potent on target cells, allowing specific signaling in selected cell types only. Type I IFN-derived AcTaferon (AFN)-targeting Clec9A+ dendritic cells (DC) displayed strong antitumor activity in murine melanoma, breast carcinoma, and lymphoma models and against human lymphoma in humanized mice without any detectable toxic side effects. Combined with immune checkpoint blockade, chemotherapy, or low-dose TNF, complete tumor regression and long-lasting tumor immunity were observed, still without adverse effects. Our findings indicate that DC-targeted AFNs provide a novel class of highly efficient, safe, and broad-spectrum off-the-shelf cancer immunotherapeutics with no need for a tumor marker.Significance: Targeted type I interferon elicits powerful antitumor efficacy, similar to wild-type IFN, but without any toxic side effects. Cancer Res; 78(2); 463-74. ©2017 AACR.
P2.03a-059 LCL161 Increases Paclitaxel-Induced Apoptosis by Degrading cIAP1 and cIAP2 in NSCLC
Authors: Chengcheng Yang, Huangzhen Wang, Boxiang Zhang, Yimeng Chen, Yamin Zhang, Xin Sun, Guodong Xiao, Kejun Nan, Hong Ren, Sida Qin
Journal: Journal of Thoracic Oncology (2017)
Bioterrorismo: crimen y oportunidad
Authors: D Byrne
Journal: Eurosurveillance (2001)

Los tragicos ataques terroristas sin precedentes que tuvieron lugar recientemente en los Estados Unidos (EE UU) han conmocionado a las administraciones de paises acostumbrados a batallas libradas en materia de gasto sanitario, pero que habian relegado a segundo plano la vigilancia y la preparacion para emergencias. La reaccion inmediata suscitada por el horror de las amenazas producidas en el otono de 2001 revelo que, en materia de salud y seguridad, los gobiernos continuan midiendo el exito en funcion del grado de tranquilidad, y ausencia de incidentes observados por los responsables sanitarios. Paradojicamente, en salud y seguridad la falta de noticias suele ser sinonimo de exito: la publicacion de noticias implica habitualmente que no son buenas.
Pseudolesions Impersonating Osseous Tumor Involvement on Both Contrast Enhanced CT and FDG PET/CT
Authors: Jessica K. Peterson, Rustain L. Morgan, Joseph S. Donald, Mark A. Perry
Journal: Clinical Nuclear Medicine (2017)

A 27-year-old man with stage IV-B Hodgkin's lymphoma status post autologous peripheral stem cell transplant in 2015 with complete response, presented in 2017 with increasing back pain. Restaging contrast enhanced CT demonstrated left brachiocephalic vein occlusion with peripheral nodular high density areas within C7-T2 vertebral bodies with corresponding radiotracer uptake on same day PET/CT. No matching lesion was seen on noncontrast CT. Findings were consistent with pooling of contrast and radiotracer within vertebral venous plexus collaterals at the cervicothoracic junction secondary to brachiocephalic vein occlusion. Repeat PET/CT with contralateral injection of radiotracer and MRI confirmed absence of osseous lymphomatous involvement.
David Oliver: We need statutory duty of candour and transparency for NHS executives
Authors: David Oliver
Journal: BMJ (2017)

Robert Francis QC’s report into historical care failings at Mid Staffordshire made over 200 recommendations.12 Most were endorsed by the government. These included a statutory duty of candour and transparency for doctors and nurses, to be enforced by their professional regulators—the General Medical Council and the Nursing and Midwifery Council. A few key recommendations were rejected or abandoned, including minimum safe nurse staffing levels and registration for healthcare assistants.3

Another recommendation seemingly deemed too difficult was statutory professional regulation for health service managers.4 This is a shame. Surely, a duty of candour and transparency should apply even more to people in such key senior roles than to a staff nurse or junior doctor: their actions or omissions affect far more patients. Suppressing or ignoring bad news was a major feature of the …
Oncological outcomes of neoadjuvant chemotherapy in patients with locally advanced upper tract urothelial carcinoma: A multicenter study
Authors: S. Hatakeyama, Y. Kubota, T. Matsumoto, O. Soma, I. Hamano, A. Kusaka, S. Hosogoe, T. Yoneyama, Y. Hashimoto, T. Koie, C. Ohyama
Journal: Annals of Oncology (2017)
The “Utility” in Composite Outcome Measures
Authors: Telba Z. Irony
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Agrupación epidémica de casos de la enfermedad del legionario: París, junio de 1998
Authors: B Decludt, L Guillotin, B van Gastel, A Perrocheau, L Capek, M Ledrans, J Etienne, D Carlier, S Jarraud, S Dubrou, M Reyrolle
Journal: Eurosurveillance (1999)

Entre el 29 de junio y el 1 de julio de 1998, cuatro casos de legionelosis en ciudadanos britanicos fueron declarados a la Red Nacional de Sanidad (Reseau National de Sante Publique, - RNSP- ), a traves del sistema de declaracion obligatoria (DO) y de la red de Vigilancia Europea de legionelosis asociada a los viajes, coordinada por el Grupo Europeo de Trabajo sobre Infecciones por Legionella (European Working Group for Legionella Infections, - EWGLI- ). Uno de los casos se detecto gracias a la red de vigilancia reforzada que se establecio con motivo de la celebracion del mundial de futbol. Los cuatro casos habian estado en Paris durante los diez dias anteriores al desarrollo de sintomas. Se realizo un estudio a fin de confirmar la existencia de un episodio epidemico, identificar una fuente comun de contaminacion y emprender medidas de control adaptadas a la situacion epidemiologica.
Myocardial Stiffness Assessment Using Shear Wave Imaging in Pediatric Hypertrophic Cardiomyopathy
Authors: Olivier Villemain, Mafalda Correia, Diala Khraiche, Ilya Podetti, Mathilde Meot, Antoine Legendre, Mickael Tanter, Damien Bonnet, Mathieu Pernot
Journal: JACC. Cardiovascular imaging (2017)
Factors associated with palliative radiotherapy in the last 30 days of life.
Authors: Susan Y. Wu, Lisa Singer, Michael A Garcia, Shannon E. Fogh, Steve E. Braunstein
Journal: Journal of Clinical Oncology (2017)

84 Background: A significant proportion of patients will undergo radiotherapy (RT) within their last 30 days of life. Identifying patients who may not benefit from RT is difficult and use of predictive models for life expectancy is not routine (Chow et al., JCO 2008; Krishnan et al., Cancer 2013). Methods: Patients treated with external beam RT to a site of metastatic disease between 2012-2016 at a single institution prior to death were included in this analysis. Mann-Whitney U and chi-squared tests were used to compare patients who received RT within 30 days of death (D 30 RT) and those who did not. Multivariate analysis was used to identify factors associated with D 30 RT. Results: 518 patients accounting for 922 palliative RT courses were included. Median age at treatment was 63 yrs (IQR 54-71 yrs), median survival time was 28 months (IQR 11-53 mos) and median time from RT to death was 74 days (IQR 33-174 days). 49% of patients were metastatic at diagnosis. The most common primary sites were lung (26%), breast (19%) and prostate (10%). The most common treatment sites were bone (56%) and brain (28%). 125 patients (24%) died within 30 days of RT. D 30 RT was associated with older median age at treatment (64 vs. 62 yrs, p = 0.04), shorter interval since diagnosis (14 vs. 31 months, p &lt; 0.001), liver but not brain or lung metastasis (p = 0.02, 0.43, and 0.06 respectively), lower median KPS scores (50 vs. 70, p &lt; 0.001), lower median BMI (22 vs. 24, p = 0.001), and inpatient status at consult (56% vs. 26%, p &lt; 0.001). Despite poor outcomes, patients who died within 30 days of RT were less likely to have hospice involved in their care (44% vs. 71%, p = 0.001). The only factor associated with hospice was longer time since diagnosis (28 months vs. 21 months, p = 0.04). D 30 RT was associated with higher Chow and TEACHH scores at the time of consult (p &lt; 0.001 for both). Conclusions: A high frequency of patients received palliative RT at the end of life in our cohort. Earlier integration of palliative care or hospice services may allow patients and physicians to optimally direct treatment at the end of life. Existing life-expectancy prediction models may allow physicians to identify patients who could benefit from short treatment courses or alternative interventions to maximize quality at the end of life.
Engineering detoxified pneumococcal pneumolysin derivative ΔA146PLY for self-biomineralization of calcium phosphate: Assessment of their protective efficacy in murine infection models
Authors: Jingwen Wu, Kaifeng Wu, Wenchun Xu, Taixian Yuan, Xiaofang Wang, Jinghui Zhang, Yajun Min, Yibing Yin, Xuemei Zhang
Journal: Biomaterials (2017)
Cortactin overexpression in the esophageal squamous cell carcinoma and its involvement in the carcinogenesis
Authors: Nan-Yung Hsu, Heng-Chien Ho
Journal: Cancer Research (2007)

3842    Objective:  The aim of this study is to examine whether dysregulated expression of cortactin occurs in esophageal squamous cell carcinoma (ESCC) and is involved in the development of ESCCs.  Methods:  Immunohistochemistry study for cortactin expression was performed on surgically resected 46 pairs of non-tumor and ESCC tumor tissues and murine tumors of esophagi induced by a carcinogen. Results:  The results show increased cortactin expression in 20 and in 22 to a lesser extent, out of total 46 ESCC tumor tissues. Increased cortactin was also detected in the premalignant lesions, the early-stage dysplasia and carcinoma in situ, of ESCC tumor tissues. Differential PCR results show slight increases in the EMS1 gene only in 2 of 10 ESCC tumor tissues, suggesting that EMS1 gene amplification is not the only mechanism for cortactin overexpression. In the mouse model induced by treatment with 4-nitroquinoline 1-oxide and arecoline, increased cortactin was detected in the epithelia with hyperkeratosis, papillomas, and ESCCs with invasion into the submucous, respectively. Conclusions:  Overall, we observed cortactin overexpression in early and late stages of human ESCCs and carcinogen-induced murine ESCCs, suggesting a role for cortactin in esophageal carcinogenesis.
What Can Thyroidectomy-Specific Outcomes Teach Us About the American College of Surgeons’ National Surgical Quality Improvement Program?
Authors: Peter Angelos
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Motivos del brusco aumento de las infecciones genitales por clamidias en los primeros meses de 2007 en Suecia
Authors: I Velicko, S Kühlmann-Berenzon, A Blaxhult
Journal: Eurosurveillance (2007)

Tras un crecimiento continuado de la incidencia de clamidiasis notificada en Suecia durante los ultimos 10 anos, dicha incidencia se redujo un 2% en 2006.
The influence of a cachexia clinic on palliative care integration in oncology.
Authors: Diane Portman, Sarah Thirlwell, Kristine A. Donovan
Journal: Journal of Clinical Oncology (2017)

124 Background: Appetite and weight loss are common in patients with advanced cancer and specialized cachexia clinics have been established to address these symptoms. Given the association between anorexia/cachexia and other adverse symptoms, these patients may also benefit from specialty level palliative care (PC). However, referral to outpatient specialty level PC is often delayed or does not occur. We sought to examine the prevalence of other factors associated with appetite and weight loss in patients with advanced cancer and the impact of a specialized cachexia clinic on identification and treatment of other PC needs. Methods: The records of patients referred by their Oncologist to the cachexia clinic of a cancer center from August 2016 to June 2017 were reviewed retrospectively. Subjects who had been referred to PC by their Oncologist were excluded. Patients had been assessed for symptom burden using the Edmonton Symptom Assessment Scale (ESAS-r). Patients identified with PC needs had been referred to the PC clinic for follow-up within 30 days after cachexia clinic consultation. Results: Thirty subjects were evaluated in the cachexia clinic (average age 68 years; 63% female). The predominant diagnosis was lung cancer (70%). An average of 6 symptoms per patient were in the moderate to severe range on ESAS, excluding appetite. Depression, fatigue and pain were most common. The average cachexia clinic total ESAS score was 51.61. Only 17% of patients had completed advance directives. Ninety-three % of patients were referred to PC and 68% were seen. The average number of PC visits was 2.79. Within the PC clinic, advance directive completion increased to 37%, goals of care discussion occurred with 50% and 17% received hospice referrals. At the most recent follow-up in the PC clinic, the average total ESAS score had decreased by 11.44 (22%) and all ESAS item scores were improved on average. Conclusions: The cachexia clinic proved a useful means to identify other PC needs and achieve effective PC referrals. We suggest this is proof of concept that specialty clinics can be a meaningful way to achieve an earlier entry point to comprehensive PC in patients who were not previously referred by their Oncologists.
Diminuzione nel riutilizzo di strumenti medici usa e getta negli ospedali danesi in seguito a una circolare che invitava ad evitarlo
Authors: M Christensen, M Meyer, O. B Jepsen
Journal: Eurosurveillance (1999)

Recentemente, in Danimarca, Finlandia, Norvegia e Svezia, sono state condotte, in 100 ospedali, delle indagini sulla frequenza di riutilizzo di strumenti classificati come 'usa e getta' (1). Un'indagine simile era gia stata intrapresa, due anni prima, negli ospedali danesi. Questo ci ha consentito di confrontare i risultati ottenuti negli ospedali danesi che hanno partecipato ad entrambe le indagini e di studiare l'effetto esercitato dalle conclusioni del primo studio, che raccomandava di non riutilizzare strumenti monouso, sulle normative interne e sui comportamenti.