tbuckley/cabot-search huggingface dataset:
SP0168 Theory of poster design and presentation
Authors: M Boers
Journal: Annals of the Rheumatic Diseases (2017)

This lecture introduces basic elements of poster design, and is followed after the session by a special poster tour devoted to design. It strongly links to the concepts discussed in my workshop on data visualization. To design an effective poster, its message and the intended audience must be clear. Effective posters stand out because they convey their main message almost instantly, and then seduce participants to stay longer and learn more. Much more than oral presentations, posters are about selling your work in competition with all those other people presenting in your session. In a good poster, all elements work together like a symphony orchestra: Title, headings, text, tables, graphs, format, colors, layout, handouts, gimmicks, and ... you! For the design process, you need a good plan (including timelines!), good tools (templates, software!) and a ruthless editor. Editing is about throwing out more and more stuff, until finally you reach the point where throwing out more destroys understanding. So the "orchestra" has single instrumentation, and is wonderfully transparent. Posters are not "comprehensive"! All the details you love can go into a specially designed handout (NOT an exact replica of your poster). Your role as presenter is special: you must be visible but unobtrusive, and flexible to accommodate different viewer styles, and have different modes of presentation (eg. walkthrough, answer questions, respond to critique). Also make sure your contact details are visible and correct (if no handout, be sure to have business cards). If you are playful you can use gimmicks to increase your visibility: match your clothes to your color scheme, make something in real 3D on your poster, use sound, etc. But don9t overdo it: this is just the icing on the cake: this is a science, not a commercial exhibit. When we go to assess posters in the upcoming poster tour, we will be looking for the following elements: 1. Overall message clear? 2. Text quality: brevity, clarity 3. Table quality: clear vision, clear understanding 4. Graph quality: clear vision, clear understanding 5. Design elements: layout, choice of font, color 6. Handout: not a replica, elements 1–5 repeated 7. Presenter: style, contact details <h3>Disclosure of Interest</h3> None declared
David Oliver: What GPs told me about how they see the future
Authors: David Oliver
Journal: BMJ (2017)

In June I wrote a column that was very supportive of primary care but asked, in view of serious current problems and an uncertain future, for a consensus from GPs themselves on the future of primary care.1 An excellent collection of rapid responses helped me (and hopefully other non-GPs) to understand the current mood.2

One point of consensus seemed clear: there simply is no consensus about future models of general practice, and we shouldn’t expect one. General practices and the communities they serve are just too diverse, and different doctors want different things from their careers. That’s OK. Most respondents found delivery and employment models secondary considerations. Some were happy to work as salaried GPs in networks or integrated care providers and for others to take on partnership.

There were points …
THU0008 Mast cells show a reprogrammed transcriptional signature following repeated igg stimulations
Authors: T Messemaker, J Suurmond, K Habets, M Heijink, J Schonkeren, A Dorjee, M Giera, T Huizinga, R Toes, F Kurreeman
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Mast cell numbers are increased in the rheumatoid arthritis joint. We have previously shown that mast cells can be activated by IgG-ACPA leading to the production of proinflammatory cytokines. However, not much is known about the resulting function when mast cells would repeatedly engage IgG, a likely scenario given the long life span of mast cells (up to a year) and the perpetual presence of IgG-ACPA in the joints. We have recently shown that mast cells triggered repeatedly through their Ig Fc epsilon receptor undergo a reprogramming of their responses (<i>Suurmond et al. JACI, 2016</i> by expressing de-novo transcribed genes in the antigen presentation and pathogen defence response pathways. <h3>Objectives</h3> The aim of the current work was to determine whether mast cells show similar changes in their response mode following repeated interactions with IgG. <h3>Methods</h3> Human cord blood-derived mast cells were treated for 2 weeks with plate-bound IgG. The expression profile of naive or treated mast cells was measured through RNA sequencing, quantitative RT-PCR, flow cytometry. Protein secretion was measured with ELISA and Luminex assays. Metabolic changes were measured using HPLC mass-spectrometry. <h3>Results</h3> Similar to our previous work on Fc Epsilon receptor, we observe a dampening of the normal IgG responses with a set of novel genes upregulated. Interestingly, de-novo expressed genes consisted of <i>DHCR7</i> and <i>DHCR24</i>, key enzymes in the cholesterol pathway. Pathway analysis confirms an enrichment of genes in this pathway following repeated IgG triggering. Preliminary data on metabolic profiling reveals a decrease in phospholipid levels in repeatedly activated mast cells. <h3>Conclusions</h3> Our study provides evidence that mast cells are reprogrammed upon repeated IgG triggering. In contrast to repeated Fc Epsilon Receptor triggering, different pathways are affected, implying stimulus-specific effects. Our work has important implications for the understanding the role of mast cells in rheumatoid arthritis. <h3>Disclosure of Interest</h3> None declared
AB1236-HPR Connection between functional ability and socio-demographic data in patients with ra in slovenia
Authors: M Pavic Nikolic, S Kosir Jost
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Rheumatoid arthritis (RA) is the most common chronic inflammatory arthritis, characterized by progressive, destructive course when left untreated, resulting in severe patient disability and significantly reduced quality of life. RA has an important impact on work ability and economic status of patients. <h3>Objectives</h3> In our study we were focused on specific consequences of arthritis in terms of functional ability and we were looking for correlation with socio-demographic data. <h3>Methods</h3> The study was conducted between January 2016 and May 2016 at the Department of Rheumatology, UMC Ljubljana and included patients with RA. Data were collected using Arthritis Impact Measurement Scales 2 (AIMS2) questionnaire. <h3>Results</h3> One hundred RA patients (76% women, mean age (SD) of 61.1±15.29 years) participated in the study. Disease duration was ± 5. 6 year. Most of our patients were married, retired with elementary education and lower incomes (Table1). Respondents of our study described their functional ability good by the average of the entire sample 2.06. This value shows us a relatively good functional ability of patients most days or very often. Patients had some problems with function of hand and wrist in particular by opening jars (43%) and on area walking and bending with intensive activity (42%). Correlation between functional ability and socio-demographic data show us some statistical deviance in age group 41 to 50 year (p=0.94), in patients with higher education level (p=0.99) and in group of patients who monthly earns more then 900€ (p=0.96). But we didn9t find any statistically significant difference in the entire sample including patients treated with biological drugs (functional ability patients on biologics p=0.91). <h3>Conclusions</h3> We found fairly good functional ability of patients; which might be explained by relatively short duration of RA. The most important functional-related issues from patient perspective were identified. Despite that we not find a statistically significant relationship between socio-demographic data and functional ability of patients, it is very important that we pay attention on socially unprivileged patients and we offer our support in managing disease. <h3>Disclosure of Interest</h3> None declared
TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis
Authors: Min Deng, Ruixin Zhang, Zhengxi He, Qinwei Qiu, Xihong Lu, Jiang Yin, Hao Liu, Xiaoting Jia, Zhimin He
Journal: Cancer Research (2017)

DNA demethylases of the TET family function as tumor suppressors in various human cancers, but their pathogenic contributions and mechanisms of action in gastric carcinogenesis and progression remain unclear. Here, we report that TET is transcriptionally upregulated in gastric cancer, where it correlates with poor prognosis. Mechanistic investigations revealed that TET facilitated gastric carcinogenesis through a noncoding function of the 3'UTR, which interacted with miR-26. This interaction resulted in sequestration of miR-26 from its target EZH2, which released the suppression on EZH2, and thereby led to EZH2 overexpression in gastric cancer. Our findings uncover a novel noncoding function for TET family proteins in facilitating gastric carcinogenesis. Cancer Res; 77(22); 6069-82. ©2017 AACR.
Bone-Inspired Spatially Specific Piezoelectricity Induces Bone Regeneration
Authors: Peng Yu, Chengyun Ning, Yu Zhang, Guoxin Tan, Zefeng Lin, Shaoxiang Liu, Xiaolan Wang, Haoqi Yang, Kang Li, Xin Yi, Ye Zhu, Chuanbin Mao
Journal: Theranostics (2017)

The extracellular matrix of bone can be pictured as a material made of parallel interspersed domains of fibrous piezoelectric collagenous materials and non-piezoelectric non-collagenous materials. To mimic this feature for enhanced bone regeneration, a material made of two parallel interspersed domains, with higher and lower piezoelectricity, respectively, is constructed to form microscale piezoelectric zones (MPZs). The MPZs are produced using a versatile and effective laser-irradiation technique in which K0.5Na0.5NbO3 (KNN) ceramics are selectively irradiated to achieve microzone phase transitions. The phase structure of the laser-irradiated microzones is changed from a mixture of orthorhombic and tetragonal phases (with higher piezoelectricity) to a tetragonal dominant phase (with lower piezoelectricity). The microzoned piezoelectricity distribution results in spatially specific surface charge distribution, enabling the MPZs to bear bone-like microscale electric cues. Hence, the MPZs induce osteogenic differentiation of stem cells in vitro and bone regeneration in vivo even without being seeded with stem cells. The concept of mimicking the spatially specific piezoelectricity in bone will facilitate future research on the rational design of tissue regenerative materials.
Phase II randomized trial of carboplatin, paclitaxel, bevacizumab with or without cixutumumab (IMC-A12) in patients with advanced non-squamous, non-small-cell lung cancer: a trial of the ECOG-ACRIN Cancer Research Group (E3508)
Authors: A. Argiris, J.W. Lee, J. Stevenson, M.G. Sulecki, V. Hugec, N.W. Choong, J.N. Saltzman, W. Song, R.M. Hansen, T.L. Evans, S.S. Ramalingam, J.H. Schiller
Journal: Annals of Oncology (2017)
Antiproliferative effect of CHR-2797, a novel aminopeptidase inhibitor, in the human breast cancer xenograft, MDA-MB 435
Authors: Leon W. Hooftman, Elisabeth A. Bone, Alan H. Drummond, Lindsey A. Needham, David O. Laber, Rajesh Odedra, Annette Wright
Journal: Cancer Research (2005)

637   The aminopeptidase inhibitor CHR-2797 is currently in Phase I clinical evaluation for the treatment of advanced malignancies CHR-2797 is a novel orally active metallo-enzyme inhibitor with pleiotropic activity against a range of human cancers. A substantial body of evidence indicates that the molecular targets underpinning these pleiotropic effects are intracellular aminopeptidases. Both CHR-2797 and an active metabolite, CHR-79888, are pharmacologically active and may exert their anti-proliferative effect by disruption of the turnover of cell cycle intermediates. CHR-2797 shows selective anti-proliferative activity against transformed cells over normal cells. The human breast carcinoma cell line, MDA-MB 435 was used for testing the activity of CHR-2797 in a murine xenograft model. Tumors were inoculated intravenously in female nude mice (18 animals per group) via the tail vein (day 0) and subsequently localized to the lungs. Oral dosing with 100 mg/kg/day commenced on day 2 after cell inoculation and continued throughout the experiment. Compared to vehicle, CHR-2797 significantly inhibited lung tumor burden by 98% (p
Woman who became infertile after hospital’s negligence is awarded costs for surrogacy
Authors: Clare Dyer
Journal: BMJ (2017)

The High Court in London has awarded damages covering the cost of surrogacy for the first time to a woman who lost her fertility through a hospital’s negligence.

Whittington Hospital NHS Trust in north London admitted liability in the case of the woman, who was diagnosed as having invasive cervical cancer at the age of 29. The trust failed to detect cancer despite smear tests in 2008 and 2012 and biopsies in 2012 and 2013.

The woman underwent chemoradiotherapy, which left her infertile and with severe radiation damage …
THU0717 Mirror visual feedback therapy improves clinical outcomes and the activity of daily living to patients with hand complex regional pain syndrome
Authors: S Patru, IR Marcu, D Matei, AM Bumbea, AC Bighea
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Wrist osteoporotic fractures may be as disabling as vertebral or hip fractures and the functional decline attributed to them is similar to that seen for arthritis and diabetes mellitus. Sometimes these fractures will lead to a painful, debilitating condition with sensory and motor disturbances, changes in vascular tone, temperature and edema- complex regional pain syndrome (CRPS). We found some clinical trials and case reports which conclude that mirror visual feedback therapy (MVFT) improves clinical outcomes and the activity of daily living to patients with hand neurological disorders, including CRPS. <h3>Objectives</h3> In this controlled randomized clinical study we tried to investigate the effects of (MVFT) in CRPS type I following osteoporosis wrist fracture. <h3>Methods</h3> We included 21 subjects with osteoporotic wrist fracture and early CRPS (duration of 3–4 weeks), with a single hand affected by allodynia, stiffness and vasomotor disturbances, from Physical Medicine and Rehabilitation outpatient clinic. They are randomly assigned into two groups: MVFT group (n=11, simply place a mirror between their two hands and train the patient by asking them to move both hands while watching the reflection of the non-affected hand in the mirror, 10 minutes for each session, four times a day) and Control group (n=10, moved both hands separated by an opaque partition between the arms). All subjects also received conventional therapy. On presentation and after 4 weeks of rehabilitation programme we assessed the wrist flexion and extension with a goniometer and the Patient-Rated Wrist Evaluation (PRWE) a 15-items questionnaire designed to measure wrist pain and disability in activities of daily living. <h3>Results</h3> Subjects in the mirror therapy group showed significant improvement in range of motion: extension increased with 50.4% vs. 41.7% and for flexion MVFT achieved 33.2% and Control group 16.8% (<i>P</i>&lt;.001). The rehabilitation programme also increased hand function with better results to 4 weeks PRWE for MVFT group (40.4 vs. 51.8, <i>P</i>=0.003). <h3>Conclusions</h3> MVF is a simple, inexpensive, without adverse events treatment option that significantly reduces pain and stiffness and improves hand mobility in early CRPS after osteoporosis wrist fracture. <h3>References</h3> Vladimir Tichelaar YI, et al. Mirror box therapy added to cognitive behavioural therapy in three chronic complex regional pain syndrome type I patients: a pilot study. Int J Rehabil Res 2007; 30: 181–8. Bache SJ, Ankcorn L, Hiller L, Gaffrey A. Two different approaches to physiotherapy management of patients with distal radius fractures. Physiotherapy. 2000;86:383. <h3>Disclosure of Interest</h3> None declared
AB1038 Influence of age on enthesis in tunisian people: an ultrasound study
Authors: K Ben Abdelghani, M Chammakhi, A Fazaa, S Rejaibi, S Kassab, S Chekili, A Laatar
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> By aging, many changes occur in the different components of the locomotor system, leading to a pathological situation such as osteoarthritis or remaining totally asymptomatic. <h3>Objectives</h3> The aim of the current study was to compare,via ultrasound, the entheseal changes in two groups of people having different ages by calculating a modified Madrid sonography enthesitis index. <h3>Methods</h3> The study was conducted in the rheumatology department of Mongi Slim hospital in Tunisia, between June 2015 and December 2016, including 17 healthy subjects. We indentified two groups: (G1) 9 persons aged &gt;50 years [51–68] and (G2) 8 persons aged ≤50 years-old [37–50]. All the included persons underwent an enthesis ultrasound exploration (EsaoteMyLab 60 machine and a 13–18 MHz linear array transducer) by a rheumatogist experimented in ultrasound. Five enthesis locations bilaterally (distal Achilles tendon, distal andproximal patellar ligaments, distal quadriceps, and brachial triceps tendons) in each person were explored.The following elemental lesions of enthesis were evaluated: thickness, presence of calcifications, erosions,enthesophyte, loss of fibrillar patternand power Doppler signal. The calculated index was compared by Mann-Whitney U test between cases and controls. The significance level was set at 5%. <h3>Results</h3> In our study population, the median age was 51.8±2.3 years and the median body mass index was 30±1 kg/m<sup>2</sup>. This last was similar between the two groups. All included subjects were female. The total enthesitis index was higher in G1 (6.67±0.91)than G2 (3.50±0.73) with a statistically significant difference (p=0.01). Considering each evaluated enthesis, the distal patellar ligament score was significantly higher in the G1 (1.67±0.55 vs 0.25±0.16 with p=0.03). For the other enthesis, there was no significantly difference between the 2 groups. <h3>Conclusions</h3> The distal patellar ligament enthesis changes shown in older persons may be the traduction of a silent-stage of knee osteoarthritis. <h3>Disclosure of Interest</h3> None declared
Bone Marrow-Derived Tenascin-C Attenuates Cardiac Hypertrophy by Controlling Inflammation
Authors: Lei Song, Lai Wang, Fuqiang Li, Ada Yukht, Minghui Qin, Haley Ruther, Mingjie Yang, Aurelio Chaux, Prediman K. Shah, Behrooz G. Sharifi
Journal: Journal of the American College of Cardiology (2017)
FRI0565 Fragility fractures in patients on depo-provera are not associated with usual risk factors for fracture
Authors: M Dey, M Bukhari
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Depo-Provera is one of the most widely-used contraceptives. The side-effects includes loss in bone mineral density (BMD), increasing fracture risk (1,2). It is not known if conventional fracture risk factors impact fracture risk in these patients. <h3>Objectives</h3> We set out to determine if the usual risk factors for fracture are associated with increased risk of fragility fractures in patients exposed to Depo-Provera. <h3>Methods</h3> Patients referred for bone densitometry at a scanner in North West of England were analysed. Femoral and vertebral BMD, height, weight and body mass index (BMI) were recorded, in addition to: age, diagnosis of rheumatoid arthritis, smoking status, alcohol consumption, family history of fractures, history of secondary osteoporosis, corticosteroid use, total average proportion fat, average tissue thickness, fat mass, and lean mass. Patients with exposure to Depo-Provera were selected for analysis. Initially patients with and without a fracture were compared using Chi-squared test and T-test. Logistic models were fitted univariately and adjusted for age to analyse association between traditional risk factors and fracture. <h3>Results</h3> 304 females (103 currently and 201 previously on Depo-Provera) were included. 62 (20.4%) had sustained had least one fragility fracture. There was no significant difference in fracture risk between those currently and previously on Depo-Provera (<i>p</i>=0.176 95% CI). Decreased left femoral BMD significantly impacted fracture risk (<i>p</i>=0.035 95% CI). All other factors investigated did not significantly increase fracture risk in this cohort.(see table below) <h3>Conclusions</h3> Our study suggests that fragility fractures in patients taking Depo-Provera are not associated with the usual risk factors for fractures. To our knowledge, this is the first study demonstrating fracture risk in such patients to be independent of conventional risk factors. This therefore indicates an as yet unidentified mechanism of increased fracture risk. Study limitations include the small number of fractures and lack of data on length of treatment with Depo-Provera. Further research is needed into the mechanisms by which the drug gives rise to increased fracture risk, independent of other factors. <h3>References</h3> Contraception. United States; 2011 Nov;84(5):e31–7. Obstet Gynecol. United States; 2008 Oct;112(4):788–99. <h3>Disclosure of Interest</h3> None declared
Mutational Frequency in Hispanic Vs. Non-Hispanic Patients with Acute Myeloid Leukemia (AML)
Authors: Jorge Monge, Christine Vaupel, Ronan T Swords, Terrence Bradley, Ryan Chapman, Naiomi Gunaratne, Jennifer R Chapman, Francisco Vega, Eric Padron, Fernando Vargas, Jeff Hall, Justin M Watts
Journal: Blood (2016)