tbuckley/cabot-search huggingface dataset:
I feel that I am being discriminated against because of a past illness and am tempted not to declare it on the health questionnaire next time I apply for a job. Can I do this?
Authors: Sam Flynn
Journal: BMJ (2004)

<i>Got a career or related related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone (www.bmjcareers.com/advicezone) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site:</i>
Investigation of the survivorship needs of patients with primary brain tumours and the provision of a health &amp; wellbeing event
Authors: Julie Emerson, Sara Robson, Liz Molloy, Charlotte Smith, Alison Gilston-hope, Sarah Cundliffe, Andrea Wadeson, Catherine McBain
Journal: Neuro-Oncology (2018)

Improvements in treatment mean that the number of people living with a brain tumour is increasing. Survivorship needs are diverse. We undertook a project to introduce routine Holistic Needs Assessment (HNA) and use the issues identified to inform the design of a survivorship event. Every patient newly-diagnosed with a primary brain tumour January-June 2016 was offered a 48-item neuro-oncology HNA at diagnosis and on completion of initial treatment, unless deemed clinically inappropriate. Patients ranked concern for each item from 1(low)-10(high). Two thresholds (>4&amp;>7) were used to identify percentages of specific concerns. Data was analysed by tumour type/grade and changes over time. The most prevalent concerns were addressed in a targeted H&amp;WB event. 154 new patients were referred to the service; 104 (68%) completed an HNA at diagnosis. These comprised: Grade IV:55, Grade III:8, Grade II:12, Meningioma:26, Other:3. 49 patients (47%) also completed a post-treatment HNA (Grade IV:36, GIII4, GII:4, Meningioma:5). There was no evidence that needs varied significantly with grade or histology. Highest ranking baseline needs were: fatigue:26%, worry/fear/anxiety:23%, fear of recurrence:22%, transport/driving:21%, mobility:17%. Post-treatment, highest-scoring concerns included sleep and appearance: fatigue:35%, fear of recurrence:27%, mobility:21%, sleep:19%, appearance:19%. Routine HNA completion proved feasible, although sometimes challenging due to time and room availability. The tool identified unreported needs; resulting conversations were valuable. ‘Sexuality’ was identified as an omission. A Health &amp; Wellbeing event, based on identified needs, was attended by 50 patients and carers. Feedback was positive with high levels of ‘usefulness’ reported, although the duration of the day proved difficult for some with fatigue and cognitive changes. Routine HNA use in an unselected patient population proved feasible and valuable, if challenging. The resulting H&amp;WB event was successful; further events are planned. Repeat HNAs later in the disease journey are required to determine how needs change.
A novel assessment of sustained unresponsiveness (SU) after long term sublingual immunotherapy (SLIT) in peanut allergic children: results of a 4 year phase II clinical trial
Authors: Ahmad Hamad, Edwin H. Kim, A. Wesley Burks, Deanna K. Hamilton, Lauren Herlihy, Sarah A. Bennick, Pamela H. Steele
Journal: Journal of Allergy and Clinical Immunology (2018)
DEDICATED PROGRAM TO ENHANCE MEASUREMENT OF LIPOPROTEIN(A) AMONG PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Gary Ma, Michael Wilkinson, Calvin Yeang, Kelsey Johnson, Anthony DeMaria, Bruno Cotter, Ryan Reeves, Mitul Patel, Ehtisham Mahmud, Sotirios Tsimikas
Journal: Journal of the American College of Cardiology (2018)
The new consultant experience
Authors: Ashok Beckaya
Journal: BMJ (2007)

We welcome your rapid responses, whether in direct response to an article in Career Focus or as a way of sharing your own ideas. As long as it isn9t libellous or offensive, we9ll post it on our website. We print a selection of rapid reponses here and the writer of the best each month wins an <i>Oxford Handbook</i> of their choice. Letter of the month prize is donated by OUP.
Physician associates will not be in UK “any time soon,” Health Foundation says
Authors: Matthew Limb
Journal: BMJ (2016)

Physician associates will not become widespread in the United Kingdom “any time soon,” workforce analysts at an independent healthcare charity and think tank, the Health Foundation, have said.

A study by the foundation said that such new roles may “grab headlines” and could fill skills gaps in the medical workforce, but it concluded that the role would not make a substantial impact over the next few years.

In an examination of various workforce “pressure points,” the Health Foundation considered whether …
Abstract 17550: Prospective and Randomized Study of Efficacy and Safety of Epicardial Ablation of Ventricular Tachycardia in Patients With Chagas Disease Using Contact Force Sensor Irrigated Tip Catheter
Authors: Cristiano Pisani, Siss Lara, Carina Hardy, Muhieddine Chokr, Hugo Bellotti, Alex Guabiru, Luciana Sacilotto, Francisco Darrieux, Denise Hachul, Mauricio Scanavacca
Journal: Circulation (2016)

Introduction: Epicardial mapping and ablation is frequently necessary for non-ischemic cardiomyopathy, especially Chagas Disease patients. Although, there is no randomized study proving its superio...
Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives
Authors: Hüseyin Enis Karahan, Christian Wiraja, Chenjie Xu, Jun Wei, Yilei Wang, Liang Wang, Fei Liu, Yuan Chen
Journal: Advanced Healthcare Materials (2018)

Abstract Graphene materials (GMs), such as graphene, graphene oxide (GO), reduced GO (rGO), and graphene quantum dots (GQDs), are rapidly emerging as a new class of broad‐spectrum antimicrobial agents. This report describes their state‐of‐the‐art and potential future covering both fundamental aspects and biomedical applications. First, the current understanding of the antimicrobial mechanisms of GMs is illustrated, and the complex picture of underlying structure–property–activity relationships is sketched. Next, the different modes of utilization of antimicrobial GMs are explained, which include their use as colloidal dispersions, surface coatings, and photothermal/photodynamic therapy agents. Due to their practical relevance, the examples where GMs function as synergistic agents or release platforms for metal ions and/or antibiotic drugs are also discussed. Later, the applicability of GMs in the design of wound dressings, infection‐protective coatings, and antibiotic‐like formulations (“nanoantibiotics”) is assessed. Notably, to support our assessments, the existing clinical applications of conventional carbon materials are also evaluated. Finally, the key hurdles of the field are highlighted, and several possible directions for future investigations are proposed. We hope that the roadmap provided here will encourage researchers to tackle remaining challenges toward clinical translation of promising research findings and help realize the potential of GMs in antimicrobial nanomedicine.
THE SEVERITY OF THE METABOLIC SYNDROME AMONG ANGIOGRAPHIED CORONARY PATIENTS PREDICTS CARDIOVASCULAR EVENTS BOTH IN PATIENTS WITH DIABETES AND IN NONDIABETIC SUBJECTS
Authors: Christoph Saely, Alexander Vonbank, Christina Lins, Daniela Zanolin, Andreas Leiherer, Axel Muendlein, Philipp Rein, Heinz Drexel
Journal: Journal of the American College of Cardiology (2018)
Multiple post-translational modifications of E-cadherin during ER stress and apoptosis
Authors: Fei Geng, Weijia Zhu, Brian Leber, David W. Andrews
Journal: Cancer Research (2006)

188   As a vital cell adhesion molecule, E-cadherin plays an important role in the suppression of tumorigenesis, tumor invasion and metastasis. Because stress and apoptosis are common events in tumors, we examined the regulation of E-cadherin expression during endoplasmic reticulum (ER) stress and apoptosis in the MCF-7 human breast cancer cell line. We used different agents to elicit ER stress and analyzed alterations of E-cadherin in MCF-7 cells by western blotting. To assay glycosylation, wheat germ agglutinin (WGA)-agarose was used to precipitate glycoproteins from cell lysates. To differentiate O-linked and N-linked glycosylation, N-linked carbohydrate was removed from samples by digestion with PNGase. Digestion with the proprotein convertase furin was used to examine pro-protein processing. Here we report that after the induction of ER stress by either thapsigargin or brefeldin A, as well as after induction of apoptosis by a cell-permeable ceramide derivative, both the mature form of E-cadherin (120 kDa) and a multiply modified form of E-cadherin (135 kDa) were detected in MCF-7 cells. PNGase digestion revealed that both forms are N-glycosylated. However, the 135 kDa form bound WGA even after PNGase digestion. Furthermore, pretreatment with tunicamycin to inhibit N-glycosylation did not reduce binding of the 135 kDa form to WGA confirming this form is also O-glycosylated. This form of E-cadherin was cleaved in vitro by furin into a mature form (120 KDa) suggesting it contains an unprocessed pro-region. Moreover, inhibition of furin generated a 135 kDa form of E-cadherin in unstressed cells. Therefore, upregulation of O-glycosylation and inhibition of proprotein processing of E-cadherin occur in response to some ER stress and apoptosis pathways. These modifications block E-cadherin cell surface transport suggesting they might lead to increased metastasis.
Initial Inflammatory Profile in Community-acquired Pneumonia Depends on Time since Onset of Symptoms
Authors: Raúl Méndez, Rosario Menéndez, Catia Cillóniz, Isabel Amara-Elori, Rosanel Amaro, Paula González, Tomás Posadas, Alexandra Gimeno, Pedro P. España, Jordi Almirall, Antoni Torres
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Rationale: Assessment of the inflammatory response can help the decision-making process when diagnosing community-acquired pneumonia (CAP), but there is a lack of information about the influence of time since onset of symptoms.Objectives: We studied the impact of the number of days since onset of symptoms on inflammatory cytokines and biomarker concentrations at CAP diagnosis in hospitalized patients.Methods: We performed a secondary analysis in two prospective cohorts including 541 patients in the derivation cohort and 422 in the validation cohort. The time since onset of symptoms was self-reported, and patients were classified as early presenters (<3 d) and nonearly presenters. Biomarkers (C-reactive protein [CRP] and procalcitonin [PCT] in both cohorts) and cytokines in the derivation cohort (IL-1, - 6, -8, -10, and tumor necrosis factor-α) were measured within 24 hours of hospital admission.Measurements and Main Results: In early presenters, CRP was significantly lower, whereas PCT, IL-6, and IL-8 were higher. Nonearly presenters showed significantly lower PCT, IL-6, and IL-8 levels. In the validation cohort, CRP and PCT exhibited identical patterns: CRP levels were 36.4% greater in patients with 3 or more days since onset of symptoms than in those with less than 3 days since symptom onset in the derivation cohort and 38.2% in the validation cohort. PCT levels were 40% lower in patients with 3 or more days since onset of symptoms in the derivation cohort and 56% in the validation cohort.Conclusions: Time since symptom onset modifies the systemic inflammatory profile at CAP diagnosis. This information has relevant clinical implications for management, and it should be taken into account in the design of future clinical trials.
Tomorrow’s teachers
Authors: Karen Hebert
Journal: BMJ (2008)

It is aimed at junior and middle grade doctors who would like to develop their teaching skills. Most participants are registrar level but there are a good number of more junior doctors, from foundation year 2 doctors upwards. The course organisers work very hard to ensure the more junior participants do not feel out of place. The course is part of a series of generic continuing professional development days that have been set up by Wessex Institute for their senior healthcare professionals, but the course is also open to external applicants. The course aims to introduce the basic principles of learning and teaching; identify educational opportunities in day to day practice; provide a forum to practise teaching skills in groups and to receive feedback; and offers an opportunity to explore …
IN-HOSPITAL OUTCOMES AFTER MITRACLIP IMPLANTATION: NATIONWIDE INPATIENT SAMPLE, 2010-2014
Authors: Sagar Mallikethi-Reddy, Ujjwal Rastogi, Emmanuel Akintoye, Rajeev Sudhakar, Melvyn Rubenfire, Cindy Grines, Luis Afonso
Journal: Journal of the American College of Cardiology (2018)
Eligibility for the shorter regimen for multidrug-resistant tuberculosis in Mexico
Authors: Marcela Munoz-Torrico, Miguel Angel Salazar, Miriam de Jesús Mohedano Millán, Jose A. Martínez Orozco, Luis A. Narvaez Diaz, Mariela Segura del Pilar, Dina Visca, Lia D'Ambrosio, Rosella Centis, Giovanni Battista Migliori
Journal: European Respiratory Journal (2018)

We read with interest the articles by Sotgiu et al . [1] and Dalcolmo et al . [2], which initiated a debate on the suitability of the shorter regimen for multidrug-resistant (MDR) tuberculosis (TB) cases in different settings [2–6]. The shorter World Health Organization (WHO) regimen [7, 8] is composed of an initial phase of 4–6 months of kanamycin, moxifloxacin, prothionamide, clofazimine, pyrazinamide, high-dose isoniazid and ethambutol, followed by 5 months of moxifloxacin, clofazimine, pyrazinamide and ethambutol. Comparing phenotypic and genotypic results in Mexico: guidance for the adoption of the shorter MDR-TB regimen <http://ow.ly/MOxJ30hXkjd>
NORMALIZATION OF QRS DURATION TO LEFT VENTRICULAR DIMENSION IMPROVES PATIENT SELECTION FOR CARDIAC RESYNCHRONIZATION THERAPY
Authors: Alwin Zweerink, Daniel Friedman, Igor Klem, Caitlin Vink, Paul Biesbroek, Steen M. Hansen, Raymond Kim, Albert van Rossum, Brett Atwater, Robin Nijveldt, Cornelis Allaart
Journal: Journal of the American College of Cardiology (2018)
MPs criticise government for lack of “affirmative action” on air pollution
Authors: Gareth Iacobucci
Journal: BMJ (2018)

The UK government has failed to protect the public from poisonous air and must act swiftly to tackle what has become “a national health emergency,” an influential group of MPs has urged.

A damning joint report by the Environment, Food and Rural Affairs Committee, the Environmental Audit Committee, the Health and Social Care Committee, and the Transport Committee said that the government’s approach so far had been more concerned with technical compliance and political convenience.1

It said that the …
Understanding the Possible Nonmedical Risks of Preexposure Prophylaxis Prescription in Adolescents
Authors: Angel B. Algarin, Gladys E. Ibañez
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
ERβ-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma
Authors: Zhenwei Han, Yong Zhang, Yin Sun, Jiaqi Chen, Chawnshang Chang, Xiaolu Wang, Shuyuan Yeh
Journal: Cancer Research (2018)

Abstract Early studies have indicated that estrogen receptor beta (ERβ) can influence the progression of clear cell renal cell carcinoma (ccRCC). Here, we report the mechanistic details of ERβ-mediated progression of ccRCC. ERβ increased ccRCC cell invasion via suppression of circular RNA ATP2B1 (circATP2B1) expression by binding directly to the 5′ promoter region of its host gene ATPase plasma membrane Ca2+ transporting 1 (ATP2B1). ERβ-suppressed circATP2B1 then led to reduced miR-204-3p, which increased fibronectin 1 (FN1) expression and enhanced ccRCC cell invasion. Targeting ERβ with shRNA suppressed ccRCC metastasis in a murine model of RCC; adding circATP2B1 shRNA partly reversed this effect. Consistent with these experimental results, ccRCC patient survival data from The Cancer Genome Atlas indicated that a patient with higher ERβ and FN1 expression had worse overall survival and a patient with higher miR-204-3p expression had significantly better overall survival. Together, these results suggest that ERβ promotes ccRCC cell invasion by altering the ERβ/circATP2B1/miR-204-3p/FN1 axis and that therapeutic targeting of this newly identified pathway may better prevent ccRCC progression. Significance: These results identify an ERβ/circATP2B1/miR-204-3p/FN1 signaling axis in RCC, suggesting ERβ and circular RNA ATP2B1 as prognostic biomarkers for this disease. Cancer Res; 78(10); 2550–63. ©2018 AACR.
Technology as a Tool for Mental Disorders—Reply
Authors: Thomas R. Insel
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insulin resistance causes inflammation in adipose tissue
Authors: Mitsugu Shimobayashi, Verena Albert, Bettina Woelnerhanssen, Irina C. Frei, Diana Weissenberger, Anne Christin Meyer-Gerspach, Nicolas Clement, Suzette Moes, Marco Colombi, Jerome A. Meier, Marta M. Swierczynska, Paul Jenö, Christoph Beglinger, Ralph Peterli, Michael N. Hall
Journal: Journal of Clinical Investigation (2018)

Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose tissue. Using a mouse model that combines genetically induced, adipose-specific insulin resistance (mTORC2-knockout) and diet-induced obesity, we found that insulin resistance causes local accumulation of proinflammatory macrophages. Mechanistically, insulin resistance in adipocytes results in production of the chemokine monocyte chemoattractant protein 1 (MCP1), which recruits monocytes and activates proinflammatory macrophages. Finally, insulin resistance (high homeostatic model assessment of insulin resistance [HOMA-IR]) correlated with reduced insulin/mTORC2 signaling and elevated MCP1 production in visceral adipose tissue from obese human subjects. Our findings suggest that insulin resistance in adipose tissue leads to inflammation rather than vice versa.
I am taking the PLAB test part 2 in 2005. I have a disabled left hand and require assistance for many medical procedures that are specific for the test. How should I discuss this with the GMC?
Authors: Brian Keighley
Journal: BMJ (2005)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone (www.bmjcareers.com/advicezone) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site.
Should we continue to consider serum cholesterol as an exogenous poisoning?
Authors: Luca Mascitelli, Mark Goldstein
Journal: British Journal of Sports Medicine (2018)

In her narrative review,1 Maryanne Demasi highlighted how an aggressive focus on lowering low-density lipoprotein-cholesterol (LDL-c), a surrogate endpoint of coronary heart disease, together with a lack of transparency surrounding the raw data on statins, has led to the overprescription of statin drugs to healthy people at low cardiovascular risk. We fully agree and wish to shed further light on the cholesterol-statin controversy.

The multifunctional importance of cholesterol for every cell in the body cannot be forgotten. It is indeed incongruous to suggest that in every individual it is …
Plk1-Mediated Phosphorylation of TSC1 Enhances the Efficacy of Rapamycin
Authors: Zhiguo Li, Yifan Kong, Longzhen Song, Qian Luo, Jinghui Liu, Chen Shao, Xianzeng Hou, Xiaoqi Liu
Journal: Cancer Research (2018)

The AKT/TSC/mTOR axis is an important pathway controlling cell growth, survival, and proliferation in response to extracellular cues. Recently, it was reported that AKT activity fluctuates across the cell cycle. However, it remains unclear whether downstream targets of AKT are also regulated by the cell cycle. Here, we report that mTORC1 activity inversely correlates with AKT activity during the cell cycle. Mechanistically, Plk1 phosphorylation of TSC1 at S467 and S578 interfered with TSC1/TSC2 binding, destabilized TSC1, promoted dissociation of the TSC complex from the lysosome, and eventually led to mTORC1 activation. Tumors derived from cancer cells expressing the TSC1-S467E/S578E mutant exhibited greater sensitivity to rapamycin than those expressing WT TSC1. Collectively, our data support a model in which Plk1, instead of AKT, regulates the TSC/mTORC1 pathway during mitosis, eventually regulating the efficacy of rapamycin.Significance: This seminal report shows that activation of mTORC1 can be independent of AKT during mitosis. Cancer Res; 78(11); 2864-75. ©2018 AACR.