tbuckley/cabot-search huggingface dataset:
해설논문 : 급성 간부전: 원인, 예후, 치료
Authors: 임영석 ( Young Suk Lim )
Journal: Clinical and Molecular Hepatology (2010)

Acute liver failure (ALF) is a rare condition in which rapid deterioration of liver function results in altered mentation and coagulopathy in individuals without previously recognized liver disease. The outcomes of patients with ALF vary greatly according to etiology, and the etiology of ALF varies markedly by geographical region. In Korea, about 90% of ALF are associated with etiologies that usually result in poor outcomes, including hepatitis B virus (HBV) infection and herbal remedies. The main causes of death in patients with ALF are increased intracranial pressure, systemic infection, and multi-organ failure. Recent advances in the intensive care of patients with ALF have contributed to a marked improvement in their overall survival. Emergency adult to adult living-donor liver transplantation (LDLT) can be performed expeditiously and safely for patients with ALF, and greatly improves survival rate as well as deceased-donor transplantation. As the window during which transplantation is possible is limited, emergency adult LDLT should be considered to be one of the first-line treatment options in patients with ALF, especially in regions in which ALFs are caused by etiologies associated with poor outcome and the supply of organs is very limited. (Korean J Hepatol 2010;16:5-18)
MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells
Authors: Katerina Cerna, Jan Oppelt, Vaclav Chochola, Katerina Musilova, Vaclav Seda, Gabriela Pavlasova, Lenka Radova, Maddalena Arigoni, Raffaele A. Calogero, Vladimir Benes, Martin Trbusek, Yvona Brychtova, Michael Doubek, Jiri Mayer, Sarka Pospisilova, Marek Mraz
Journal: Leukemia (2018)
Expression of Opioid Receptors During Heart Ontogeny in Normotensive and Hypertensive Rats
Authors: ReuvenZimlichman, DovGefel, HeskelEliahou, ZiporaMatas, BoazRosen, SvetlanaGass, CatherineEla, YaelEilam, ZviVogel, JacobBarg
Journal: Circulation (1996)

Background The opioidergic systems are involved in modulating nociceptive stimuli. In addition, recent results suggest that endogenous and exogenous opioids could play a role in the modulation of blood pressure and cardiac functions. However, little is known regarding the expression and role of opioid-binding sites in the heart. The decreased sensitivity to noxious stimuli in hypertensive rats raises the possibility of different developmental pattern expression of opioid-binding sites in normotensive versus hypertensive rats. Methods and Results Opioid receptor expression in hearts from hypertensive and normotensive rats was studied during heart development by binding assays. From P1 until P90, the development of the heart in the two rat strains was accompanied by a gradual increase in the density of κ-opioid receptors. Hearts from hypertensive rats expressed significantly higher levels of κ receptors compared with those of normotensive rats. At ages older than P7, μ-opioid receptors could not be detected...
Electrode Catheters and the Diagnostic Application of Intracardiac Electrography in Small Children
Authors: Hamishwatson
Journal: Circulation (1964)

The history of intracardiac electrography has been reviewed with particular reference to its practical application. The increasing versatility of electrode catheters is stressed and a new multipurpose diagnostic catheter with a platinum electrode is described. Electrograms chosen from 500 consecutive cases have been presented to demonstrate the use of an intracardiac lead during routine cardiac catheterization, and the special value of this technic in the investigation of congenital heart disease in babies and small children is emphasized.
Abstract 3051: Prognostic value of 18F-FDG PET/CT parameters in patients with primary pulmonary lymphoepithelioma-like carcinoma
Authors: Yueh-Fu Fang, Chun-Yu Lin
Journal: Cancer Research (2018)

Abstract Introduction Pretreatment tumor metabolic burden, which measured by fluorine-18 fluorodeoxyglucose positron emission tomography/computerized tomography (18F-FDG PET/CT) have been shown to predict outcomes in various malignancies. Epstein-Barr virus (EBV) serology titer in pulmonary LELC is correlated to stage. However, the prognostic value of 18F-FDG PET/CT in patients with pulmonary lymphoepithelioma-like carcinoma (LELC) and the relationship between EBV viral load remained unknown. The current study aims to investigate the prognostic value and association between functional parameters of 18F-FDG PET/CT and serum EBV DNA in patients with pulmonary LELC. Methods This retrospective study comprised 32 patients with pulmonary LELC who underwent pretreatment 18F-FDG PET/CT between January 2008 and December 2016. The EBV viral load and the functional parameters of 18F-FDG PET/CT were used for survival analysis. Results The value of pre-treatment serum EBV DNA had significantly positive correlation with whole MTV (r = 0.63, P = 0.0337) and whole TLG (r = 0.77, P = 0.0093). Advanced tumor stage (≥III) and high whole MTV (≥72.58) significantly predicted poor PFS. Multivariate survival analysis for PFS showed that there was a trend toward a lower risk of recurrence in patients with early tumor stage (≤II) (HR = 0.112, 95% CI =0.011-1.117, P = 0.062, Table 3), albeit not significantly so. Advanced tumor stage (≥III), high whole MTV (≥72.58) and high whole TLG (≥278.4) were predictors of poor OS. However, in multivariate survival analysis, none of them were independent predictors for OS. EBV viral load was not prognostic factor for both PFS and OS. Conclusion Greater whole MTV and whole TLG predicted poorer OS in patients with primary pulmonary LELC. Functional parameter of 18F-FDG PET/CT may provide useful prognostic information. Serum EBV DNA was closely related to whole MTV and TLG, but not a prognostic factor. Citation Format: Yueh-Fu Fang, Chun-Yu Lin. Prognostic value of 18F-FDG PET/CT parameters in patients with primary pulmonary lymphoepithelioma-like carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3051.
Intracellular Sodium Accumulation During Ischemia as the Substrate for Reperfusion Injury
Authors: KenichiImahashi, HideoKusuoka, KatsujiHashimoto, JunYoshioka, HitoshiYamaguchi, TsunehikoNishimura
Journal: Circulation Research (1999)

Abstract—To elucidate the role of intracellular Na+ kinetics during ischemia and reperfusion in postischemic contractile dysfunction, intracellular Na+ concentration ([Na+]i) was measured in isolated perfused rat hearts using 23Na nuclear magnetic resonance spectroscopy. The extension of the ischemic period from 9 minutes to 15, 21, and 27 minutes (at 37°C) increased [Na+]i at the end of ischemia from 270.0±10.4% of preischemic level (mean±SE, n=5) to 348.4±12.0% (n=5), 491.0±34.0% (n=7), and 505.3±12.1% (n=5), respectively, whereas the recovery of developed pressure worsened with the prolongation of the ischemic period (95.1±4.2%, 84.3±1.2%, 52.8±13.7%, and 16.9±6.4% of preischemic level). The kinetics of [Na+]i recovery during reperfusion was analyzed by the fitting of a monoexponential function. When the hearts were reperfused with low–[Ca]o (0.15 mmol/L) solution, the time constants of the recovery (τ) after 15-minute (8.07±0.85 minutes, n=5) and 21-minute ischemia (6.44±0.90, n=5) were significantly ...
Computed Tomography Coronary Angiography in Patients With Acute Myocardial Infarction Without Significant Coronary Stenosis
Authors: AnnachiaraAldrovandi, FilippoCademartiri, DanieleArduini, DanielaLina, FabrizioUgo, EricaMaffei, AlbertoMenozzi, ChiaraMartini, AlessandroPalumbo, FedericoBontardelli, TizianoGherli, LiviaRuffini, DiegoArdissino
Journal: Circulation (2012)

Background—It is known that a significant number of patients experiencing an acute myocardial infarction have normal coronary arteries or nonsignificant coronary disease at coronary angiography (CA). Computed tomography coronary angiography (CTCA) can identify the presence of plaques, even in the absence of significant coronary stenosis. This study evaluated the role of 64-slice CTCA in detecting and characterizing coronary atherosclerosis in these patients. Methods and Results—Consecutive patients with documented acute myocardial infarction but without significant coronary stenosis at CA underwent late gadolinium-enhanced magnetic resonance and CTCA. Only the 50 patients with an area of myocardial infarction identified by late gadolinium-enhanced magnetic resonance were included in the study. All of the coronary segments were assessed for the presence of plaques. CTCA identified 101 plaques against the 41 identified by CA: 61 (60.4%) located in infarct-related arteries (IRAs) and 40 (39.6%) in non-IRAs. ...
In silico validation of the Autoinflammatory Disease Damage Index
Authors: Nienke M ter Haar, Amber Laetitia Justine van Delft, Kim Valerie Annink, Henk van Stel, Sulaiman M Al-Mayouf, Gayane Amaryan, Jordi Anton, Karyl S Barron, Susanne Benseler, Paul A Brogan, Luca Cantarini, Marco Cattalini, Alexis-Virgil Cochino, Fabrizio de Benedetti, Fatma Dedeoglu, Adriana Almeida de Jesus, Erkan Demirkaya, Pavla Dolezalova, Karen L Durrant, Giovanna Fabio, Romina Gallizzi, Raphaela Goldbach-Mansky, Eric Hachulla, Veronique Hentgen, Troels Herlin, Michaël Hofer, Hal M Hoffman, Antonella Insalaco, Annette F Jansson, Tilmann Kallinich, Isabelle Kone-Paut, Anna Kozlova, Jasmin Beate Kuemmerle-Deschner, Helen J Lachmann, Ronald M Laxer, Alberto Martini, Susan Nielsen, Irina Nikishina, Amanda K Ombrello, Seza Özen, Efimia Papadopoulou-Alataki, Pierre Quartier, Donato Rigante, Ricardo Russo, Anna Simon, Maria Trachana, Yosef Uziel, Angelo Ravelli, Grant Schulert, Marco Gattorno, Joost Frenkel
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Introduction</h3> Autoinflammatory diseases can cause irreversible tissue damage due to systemic inflammation. Recently, the Autoinflammatory Disease Damage Index (ADDI) was developed. The ADDI is the first instrument to quantify damage in familial Mediterranean fever, cryopyrin-associated periodic syndromes, mevalonate kinase deficiency and tumour necrosis factor receptor-associated periodic syndrome. The aim of this study was to validate this tool for its intended use in a clinical/research setting. <h3>Methods</h3> The ADDI was scored on paper clinical cases by at least three physicians per case, independently of each other. Face and content validity were assessed by requesting comments on the ADDI. Reliability was tested by calculating the intraclass correlation coefficient (ICC) using an 'observer-nested-within-subject' design. Construct validity was determined by correlating the ADDI score to the Physician Global Assessment (PGA) of damage and disease activity. Redundancy of individual items was determined with Cronbach's alpha. <h3>Results</h3> The ADDI was validated on a total of 110 paper clinical cases by 37 experts in autoinflammatory diseases. This yielded an ICC of 0.84 (95% CI 0.78 to 0.89). The ADDI score correlated strongly with PGA-damage (r=0.92, 95% CI 0.88 to 0.95) and was not strongly influenced by disease activity (r=0.395, 95% CI 0.21 to 0.55). After comments from disease experts, some item definitions were refined. The interitem correlation in all different categories was lower than 0.7, indicating that there was no redundancy between individual damage items. <h3>Conclusion</h3> The ADDI is a reliable and valid instrument to quantify damage in individual patients and can be used to compare disease outcomes in clinical studies.
Abstract 3318: Frequent promoter hypermethylation correlates with better prognosis in pharyngeal cancer
Authors: Takuya Nakagawa, Keisuke Matsusaka, Kiyoshi Misawa, Masaki Fukuyo, Kiyoko Takane, Toyoyuki Hanazawa, Hisahiro Matsubara, Yoshitaka Okamoto, Atsushi Kaneda
Journal: Cancer Research (2018)

Abstract The incidence of Human Papilloma Virus (HPV) associated oropharyngeal cancer is dramatically increasing in developed countries, due to mainly HPV 16. Whereas viral infection status could affect molecular subtypes in other cancers, molecular features of HPV(+) and HPV(-) OPSCCs including epigenetic aberrations are not fully clarified. We here performed genome-wide DNA methylation analysis of OPSCC. We identified 144 candidate methylation-associated silencing genes using Infinium 450k analysis of 13 OPSCC samples, 4 normal mucosal samples and two HNSCC cell lines with/without 5Aza/TSA. Re-expression of the hypermethylated genes by 5-aza-2-deoxycytidine was confirmed by RNA-seq. Among the 144 candidate genes, 9 genes were selected and their methylation status was analyzed in 70 pharyngeal SCC cases including 55 OPSCC and 15 hypopharyngeal SCC cases using pyrosequencing. HPV(+) samples showed higher methylation level within all the samples (P=0.0002, t-test) and within OPSCC (P=0.001, t-test). While HPV infection significantly correlated with positive staining of p16 in immunohistochemistry, HPV(+) as well as p16(+) status significantly correlated with better prognosis (P = 0.005 and 0.002, log-rank test). The aberrant hypermethylation of an identified marker gene also correlated with better prognosis significantly when all the cases were analyzed (P = 0.04). Interestingly, the its hypermethylation status also correlated with better prognosis within p16(-) cases (P = 0.03). Our data suggest that aberrant DNA methylation might be involved in genesis of OPSCC, that DNA methylation might associate with HPV infection, and that methylation marker might work as prognostic marker. To elucidate the correlation between DNA methylation and OPSCC including HPV(+) and HPV(-) OPSCCs, we additionally performed genome-wide DNA methylation analysis of OPSCC using Infinium 450k analysis of 83 OPSCC samples, and integrated our data with 81 OPSCC data from the Cancer Genome Atlas (TCGA). HPV(+) and HPV(-) OPSCCs were mainly classified into two epigenotypes, respectively. Analyzing the correlation with clinicopathological data, we created a new classification strategy for OPSCC. Citation Format: Takuya Nakagawa, Keisuke Matsusaka, Kiyoshi Misawa, Masaki Fukuyo, Kiyoko Takane, Toyoyuki Hanazawa, Hisahiro Matsubara, Yoshitaka Okamoto, Atsushi Kaneda. Frequent promoter hypermethylation correlates with better prognosis in pharyngeal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3318.
Initiation of Atrial Fibrillation by Ectopic Beats Originating From the Superior Vena Cava
Authors: Chin-FengTsai, Ching-TaiTai, Ming-HsiungHsieh, Wei-ShiangLin, Wen-ChungYu, Kwo-ChangUeng, Yu-AnDing, Mau-SongChang, Shih-AnnChen
Journal: Circulation (2000)

Background—The superior vena cava (SVC) has cardiac musculature extending from the right atrium. However, no previous study in humans has given details regarding the ectopic foci that initiate paroxysmal atrial fibrillation (PAF), which may originate from the SVC. Methods and Results—A total of 130 patients with frequent attacks of PAF initiated by ectopic beats were included. Eight patients (6%) had spontaneous AF initiated by a burst of rapid ectopic beats from the SVC (located 19±7 mm above the junction of the SVC and right atrium), which was confirmed by multiplane angiographic and intracardiac echocardiographic visualization and was marked by a sharp SVC potential preceding atrial activity. During initial repetitive discharges, the group with SVC ectopy had a higher incidence of intravenous conduction block than the group with pulmonary vein ectopy (75% versus 37%; P=0.03). The activation time of the earliest intracardiac ectopic activities relative to ectopic P wave onset was significantly shorter i...
THU0240 The size and frequency of bone marrow oedema on sacroiliac joint mri differs in a cluster-wise comparison of patients with findings suggestive of axial spondyloarthritis
Authors: A.A. Christiansen, A.G. Loft, K. Hørslev-Petersen, S. Juhl-Pedersen, U. Weber, L.T. Hermansen, B. Arnbak, A. Zejden, B. Schiøttz-Christensen, C. Manniche, O. Hendricks
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Multiple correspondence analysis (MCA) is a statistical method that allows for the translation of data from multiple categorical variables into single coordinates per individual. When combined with cluster analysis, individuals that share phenotypic characteristics can be grouped together. The Assessment of Axial Spondyloarthritis international Society (ASAS) published classification criteria for axial spondyloarthritis (axSpA) in 2009<sup>1</sup> that included active sacroiliitis on magnet resonance imaging (MRI) of the sacroiliac joints (SIJ) defined as bone marrow oedema (BME) present in either as 2 lesions on one slice, or 1 lesion on 2 consecutive slices.<sup>2</sup> It has been shown that extent of BME is associated with risk of radiographic progression.<sup>3</sup> <h3>Objectives</h3> To identify phenotypes in low back pain (LBP) patients recruited from primary care with findings suggestive of early axSpA and to assess differences in size and frequency of BME lesions on SIJ MRI. <h3>Methods</h3> Age, gender and the ASAS SpA features (SIJ BME on MRI, HLA-B27, inflammatory back pain, arthritis, heel enthesitis, uveitis, psoriasis, inflammatory bowel disease, good response to NSAIDs, family history of SpA, but not dactylitis (not observed) or radiographic sacroiliitis) of 134 LBP patients who either met of were one feature short of meeting the ASAS classification criteria for axSpA were analysed by MCA and subsequent k-means cluster analysis in order to identify various clinical phenotypes. The above listed SpA features, and if present, the size and frequency of SIJ BME as defined by the Aarhus scoring module,<sup>4</sup> were compared across clusters. <h3>Results</h3> MCA and cluster analysis revealed 3 clusters. Cluster 1 was predominantly HLA-B27 positive (96.7%) with SIJ BME in half of the cases. Cluster 2 and 3 had SIJ BME in all cases. Cluster 3 had fewer features suggestive of axSpA than clusters 1 and 2. There were significant differences in frequency (3.0 vs 2.0 vs 1.0) and extent of BME (4.0 vs 2.0 vs 1.0) across clusters 1, 2 and 3. <h3>Conclusions</h3> Three clusters were identified among LBP patients with findings suggestive of axSpA: 1 predominantly HLA-B27 positive cluster with SIJ BME in half of the subjects, and 2 clusters having less features suggestive of SpA and with SIJ BME in all subjects. The predominantly HLA-B27 positive cluster had more and larger BME lesions than the other 2, which may indicate individuals at risk for progression. <h3>References</h3> [1] Ann Rheum Dis2009;68(6):777–83; [2] Ann Rheum Dis2009;68(10):1520–7. [3] Arthritis Rheum2008;58(11):3413–3418. [4] AC&amp;R. 2010;62(1):11–8. <h3>Disclosure of Interest</h3> None declared
Lung cancer staging: imagine fewer images
Authors: Kurt G. Tournoy, Jan P. Van Meerbeeck
Journal: European Respiratory Journal (2018)

The update on lung cancer staging published by the European Respiratory Journal [1] is a welcome overview of a field characterised by fast evolution of therapeutic modalities. The accurate staging of lung cancer is of utmost importance for an optimal outcome. Since value of care incorporates outcome over cost as a surrogate of the quality achieved [2], one must be very attentive in recommending the necessary staging investigations. There is no place for reflex brain MRI in any patient with early stage non-small cell lung cancer being considered for a therapy with curative intent <http://ow.ly/I5O530kI5vQ>
Abstract 2054: Tumor endothelial cells survive under lactic acidosis
Authors: Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Yasuhiro Hida, Kyoko Hida
Journal: Cancer Research (2018)

Abstract Tumor endothelial cells (TECs) which line tumor blood vessels differ functionally, structurally and genetically from normal endothelial cells (NECs). Recent findings have furthermore shown that TECs are hyper-glycolytic, making them a significant source of lactic acid within the tumor. Similar to TECs, tumor cells are also preferably glycolytic and release large amounts of lactic acid. Consequently, TECs may be influenced by both intrinsic and tumor-derived lactic acid. However, the effects of lactic acidic on TECs have not been elucidated. Moreover, with the quest to find novel therapeutic antiangiogenic targets, it is of much essence to identify adaptive mechanisms supporting TECs under conditions of lactic acidosis. In this study, metabolomic analysis was performed in TECs and NECs. TECs had significantly higher intracellular levels of glycolytic metabolites, lactate, ATP and amino acids than NECs. Additionally, unlike NECs, TECs proliferated when exposed to conditions of lactic acidosis (20mM lactate, pH 6.9) and not under lactosis (20mM lactate, pH 7.3). This observation implied that TECs survive and sustain their growth under low pH conditions but in the presence of lactate. Furthermore, qRT -PCR analysis revealed an elevated expression of proton-coupled transporters in TECs than in NECs. The TECs were sensitive to drugs targeting some of the transporters. This indicated that proton-coupled transporters may be involved in the survival and proliferation of TECs in lactic acidosis. Next, the effects of lactic acidosis on tumor blood vessels, particularly endothelial cellular junctions was investigated. VE-cadherin expression was analysed by immunocytochemistry in endothelial cells exposed to lactosis and lactic acidosis. The VE-cadherin was more disorganized under lactic acidosis than in lactosis. Lactic acidosis may therefore contribute to the poor integrity of tumor blood vessels. More studies are on-going to elucidate the molecular effects of lactic acidosis on TECs and the role played by proton-coupled transporters in TECs survival in the tumor microenvironment. These will lead to the identification of a proton-coupled transporter as an antiangiogenic therapeutic target. Citation Format: Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Yasuhiro Hida, Kyoko Hida. Tumor endothelial cells survive under lactic acidosis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2054.