Hyoscyamine for a Slow Ventricular Response During Atrial Fibrillation
Authors: Scott A. Helgeson, Edson J. Mwakyanjala, Pragnesh P. Parikh, K.L. Venkatachalam
Journal: Annals of Internal Medicine (2018)

Letters18 September 2018Hyoscyamine for a Slow Ventricular Response During Atrial FibrillationScott A. Helgeson, MD, Edson J. Mwakyanjala, MD, Pragnesh P. Parikh, MD, and K.L. Venkatachalam, MDScott A. Helgeson, MDMayo Clinic, Jacksonville, Florida (S.A.H., E.J.M., P.P.P., K.V.)Search for more papers by this author, Edson J. Mwakyanjala, MDMayo Clinic, Jacksonville, Florida (S.A.H., E.J.M., P.P.P., K.V.)Search for more papers by this author, Pragnesh P. Parikh, MDMayo Clinic, Jacksonville, Florida (S.A.H., E.J.M., P.P.P., K.V.)Search for more papers by this author, and K.L. Venkatachalam, MDMayo Clinic, Jacksonville, Florida (S.A.H., E.J.M., P.P.P., K.V.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Atrial fibrillation typically presents with tachycardia; atrial fibrillation with bradycardia is much less common. Bradycardia may be due to increased vagal tone, drugs affecting the atrioventricular node, or conduction system disease. Symptomatic bradycardia caused by conduction system disease is often treated with a pacemaker, because medications are not usually effective. Atropine, glycopyrrolate, hyoscyamine, and other anticholinergic drugs inhibit receptors that are present in smooth and cardiac muscle, the sinoatrial and atrioventricular node, and the exocrine glands (1–3). These drugs are often used to inhibit gastrointestinal propulsion and decrease urinary bladder contractions and secretions of the pharynx, stomach, trachea, and ...References1. Green DW, Bristow AS, Fisher M. Comparison of i.v. glycopyrrolate and atropine in the prevention of bradycardia and arrhythmias following repeated doses of suxamethonium in children. Br J Anaesth. 1984;56:981-5. [PMID: 6466532] CrossrefMedlineGoogle Scholar2. Product information: glycopyrrolate intramuscular injection, intravenous injection, glycopyrrolate intramuscular injection, intravenous injection. Shirley, NY: American Regent; 2009. Google Scholar3. Product information: CUVPOSA oral solution, glycopyrrolate oral solution. Atlanta: Shionogi Pharma; 2010. Google Scholar Author, Article, and Disclosure InformationAffiliations: Mayo Clinic, Jacksonville, Florida (S.A.H., E.J.M., P.P.P., K.V.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0037. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHyoscyamine for a Slow Ventricular Response During Atrial Fibrillation Neelesh Gupta Hyoscyamine for a Slow Ventricular Response During Atrial Fibrillation Scott A. Helgeson , Edson J. Mwakyanjala , Pragnesh P. Parikh , and K.L. Venkatachalam Metrics Cited byStructural insights on the interaction potential of natural leads against major protein targets of SARS-CoV-2: Molecular modelling, docking and dynamic simulation studiesHyoscyamine for a Slow Ventricular Response During Atrial FibrillationNeelesh Gupta, MD 18 September 2018Volume 169, Issue 6Page: 418-419KeywordsAtrial fibrillationBradycardiaDrugsElectrocardiographyHeart ratePacemakersRight bundle branch blockSyncopeSystemic diseasesTachycardia ePublished: 15 May 2018 Issue Published: 18 September 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...