tbuckley/cabot-search huggingface dataset:
Micelle‐Coated, Hierarchically Structured Nanofibers with Dual‐Release Capability for Accelerated Wound Healing and Infection Control
Authors: Victoria Albright, Meng Xu, Anbazhagan Palanisamy, Jun Cheng, Mary Stack, Beilu Zhang, Arul Jayaraman, Svetlana A. Sukhishvili, Hongjun Wang
Journal: Advanced Healthcare Materials (2018)

Tailoring nanofibrous matrices-a material with much promise for wound healing applications-to simultaneously mitigate bacterial colonization and stimulate wound closure of infected wounds is highly desirable. To that end, a dual-releasing, multiscale system of biodegradable electrospun nanofibers coated with biocompatible micellar nanocarriers is reported. For wound healing, transforming growth factor-β1 is incorporated into polycaprolactone/collagen (PCL/Coll) nanofibers via electrospinning and the myofibroblastic differentiation of human dermal fibroblasts is locally stimulated. To prevent infection, biocompatible nanocarriers of polypeptide-based block copolymer micelles are deposited onto the surfaces of PCL/Coll nanofibers using tannic acid as a binding partner. Micelle-modified fibrous scaffolds are favorable for wound healing, not only supporting the attachment and spreading of fibroblasts comparable to those on noncoated nanofibers, but also significantly enhancing fibroblast migration. Micellar coatings can be loaded with gentamicin or clindamycin and exhibit antibacterial activity as measured by Petrifilm and zone of inhibition assays as well as time-dependent reduction of cellular counts of Staphylococcus aureus cultures. Moreover, delivery time of antibiotic dosage is tunable through the application of a novel modular approach. Altogether, this system holds great promise as an infection-mitigating, cell-stimulating, biodegradable skin graft for wound management and tissue engineering.
P142Anti-fibrotic effects of cardiac progenitor cells in a 3D-model of human cardiac fibrosis
Authors: T Bracco Gartner, J C Deddens, E A Mol, M M Ferrer, L W Van Laake, CVC Bouten, A Khademhosseini, WJL Suyker, JPG Sluijter, J Hjortnaes
Journal: Cardiovascular Research (2018)
Streptavidin-mirror DNA tetrahedron hybrid as a platform for intracellular and tumor delivery of enzymes
Authors: Kyoung-Ran Kim, Dohyeon Hwang, Juhyeon Kim, Chang-Yong Lee, Wonseok Lee, Dae Sung Yoon, Dongyun Shin, Sun-Joon Min, Ick Chan Kwon, Hak Suk Chung, Dae-Ro Ahn
Journal: Journal of Controlled Release (2018)
Global Prevalence of Presbyopia and Vision Impairment from Uncorrected Presbyopia
Authors: Timothy R. Fricke, Nina Tahhan, Serge Resnikoff, Eric Papas, Anthea Burnett, Suit May Ho, Thomas Naduvilath, Kovin S. Naidoo
Journal: Ophthalmology (2018)

Presbyopia prevalence and spectacle-correction coverage were estimated by systematic review and meta-analysis of epidemiologic evidence, then modeled to expand to country, region, and global estimates.Understanding presbyopia epidemiologic factors and correction coverage is critical to overcoming the burden of vision impairment (VI) from uncorrected presbyopia.We performed systematic reviews of presbyopia prevalence and spectacle-correction coverage. Accepted presbyopia prevalence data were gathered into 5-year age groups from 0 to 90 years or older and meta-analyzed within World Health Organization global burden of disease regions. We developed a model based on amplitude of accommodation adjusted for myopia rates to match the regionally meta-analyzed presbyopia prevalence. Presbyopia spectacle-correction coverage was analyzed against country-level variables from the year of data collection; variation in correction coverage was described best by a model based on the Human Development Index, Gini coefficient, and health expenditure, with adjustments for age and urbanization. We used the models to estimate presbyopia prevalence and spectacle-correction coverage in each age group in urban and rural areas of every country in the world, and combined with population data to estimate the number of people with near VI.We estimate there were 1.8 billion people (prevalence, 25%; 95% confidence interval [CI], 1.7-2.0 billion [23%-27%]) globally with presbyopia in 2015, 826 million (95% CI, 686-960 million) of whom had near VI because they had no, or inadequate, vision correction. Global unmet need for presbyopia correction in 2015 is estimated to be 45% (95% CI, 41%-49%). People with presbyopia are more likely to have adequate optical correction if they live in an urban area of a more developed country with higher health expenditure and lower inequality.There is a significant burden of VI from uncorrected presbyopia, with the greatest burden in rural areas of low-resource countries.
An unsettled debate: Key empirical and theoretical questions are still open – CORRIGENDUM
Authors: Stefano Vincini, Yuna Jhang, Eugene H. Buder, Shaun Gallagher
Journal: Behavioral and Brain Sciences (2018)

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P356Fzd5 signalling controls vascular growth by repressing Ets1-mediated transcription of Angpt2 and Flt1
Authors: M M Brandt, CGM Van Dijk, I Chrifi, H M Kool, L Louzao-Martinez, J Pei, R J Rottier, M C Verhaar, D J Duncker, C Cheng
Journal: Cardiovascular Research (2018)
Wearable Brain Scanner Allows Imaging During Movement
Authors: Jennifer Abbasi
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pedunculated Hepatocellular Carcinoma Mimicking Right Adrenal Tumor on FDG PET/CT
Authors: Aisheng Dong, Xinping Zhong, Yang Wang
Journal: Clinical Nuclear Medicine (2018)

Abstract Pedunculated hepatocellular carcinoma is an unusual form of hepatocellular carcinoma protruding from the liver with or without a pedicle. We present a case of pedunculated hepatocellular carcinoma misdiagnosed as right adrenal tumor on MRI and FDG PET/CT. Intraoperative exploration revealed the mass was attached to the liver, but the right adrenal gland was intact. Laparoscopic biopsy revealed poorly differentiated hepatocellular carcinoma. This case indicates it may be difficult to diagnose pedunculated hepatocellular carcinoma because it is hard to define its origin on imaging. Elevated alpha-fetoprotein level and a history of viral hepatitis may be helpful for the diagnosis.
Translational genomics in pancreatic ductal adenocarcinoma: A review with re-analysis of TCGA dataset
Authors: Jeffery Ho, Xianchun Li, Lin Zhang, Yonghao Liang, Wei Hu, Johnny C.W. Yau, Hung Chan, Tony Gin, Matthew T.V. Chan, Gary Tse, William K.K. Wu
Journal: Seminars in Cancer Biology (2018)
Immediate implant placement and provisionalization of maxillary anterior single implants
Authors: Joseph Yun Kwong Kan, Kitchai Rungcharassaeng, Matteo Deflorian, Tommaso Weinstein, Hom‐Lay Wang, Tiziano Testori
Journal: Periodontology 2000 (2018)

Abstract An inevitable loss of soft and hard tissue after tooth extraction often results in a compromised site for anterior implant esthetics in both vertical and horizontal dimensions. Immediate implant placement and provisionalization has been a viable option for replacing failing maxillary anterior teeth as it preserves the vertical existing osseous and gingival architecture. With the simultaneous addition of soft‐ and hard‐tissue grafts, the peri‐implant horizontal tissue topography can also be maintained. The esthetic success of immediate implant placement and provisionalization procedures is influenced by a number of factors that can be identified as patient‐dependent or clinician‐dependent. This article describes in detail the process of patient selection, indications, contraindications, diagnosis, treatment planning and treatment execution required to achieve functional and esthetic success with immediate implant placement and provisionalization.
A proteomics analysis of cell signaling pathways in colon cancer.
Authors: Oleg Ivanovich Kit, Dmitriy I. Vodolazhsky, Denis S. Kutilin, Yaroslav S. Enin, Yuri Gevorkyan, Leonid V. Kharin, Svetlana B. Panina
Journal: Journal of Clinical Oncology (2018)

608 Background: Colorectal cancer is the second most common cancer in women and third most common cancer in men. Major signaling pathways are known to be deregulated in cancer, however, there are only a few studies addressing activation status of more than one or two pathways in colorectal cancer in comparison with the normal tissue. The present study aims to compare the expression pattern of proteins associated with cell signaling in paired tumor and non-tumor samples of patients with colon cancer, as well as to define the cluster of proteins to differentiate patients with non-metastatic (Dukes’ grade B) and metastatic (Dukes’ grade C&amp;D) colon cancer. Methods: Frozen tumor and non-tumor samples were collected after tumor resection from 19 patients with colon cancer. The "Panorama" (Sigma-Aldrich) Antibody Microarray-Cell Signaling kits were used for the analyses. The expression ratios of paired tumor/non-tumor samples were calculated for the each protein. We employed R packages ‘samr’, ‘gplots’, ‘supclust’ ( pelora, wilma algorithms), ‘glmnet’ for the differential expression analysis, supervised clustering and penalized logistic regression, respectively. Results: Significance analysis of microarrays revealed 9 up-regulated proteins, including protein kinase C gamma, c-Myc, MDM2, bCOP, p14ARF, p57kip2, GRB2, APP, pan cytokeratin, and 1 down-regulated protein (GAP1) in tumoral mucosa. Pan cytokeratin and amyloid precursor protein were up-regulated in tumor vs. non-tumor tissue, and were selected in the predictive cluster to discriminate colon cancer type. Higher levels of S-100b and phospho-Tau-pSer199/202 were confirmed as the predictors of non-metastatic colon cancer by all of employed regression/clustering methods. Conclusions: Deregulated proteins in colon cancer are involved in oncogenic signal transduction, cell cycle control, and regulation of cytoskeleton formation/transport. Further studies are needed to validate potential protein markers of colon cancer development and metastatic progression.
Cardiovascular disease risk prediction equations in 400 000 primary care patients in New Zealand: a derivation and validation study
Authors: Romana Pylypchuk, Sue Wells, Andrew Kerr, Katrina Poppe, Tania Riddell, Matire Harwood, Dan Exeter, Suneela Mehta, Corina Grey, Billy P Wu, Patricia Metcalf, Jim Warren, Jeff Harrison, Roger Marshall, Rod Jackson
Journal: The Lancet (2018)
Impact of the US Food and Drug Administration–Approved Sex-Specific Cutoff Values for High-Sensitivity Cardiac Troponin T to Diagnose Myocardial Infarction
Authors: Maria Rubini Gimenez, Patrick Badertscher, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Desiree Wussler, Òscar Miró, F. Javier Martín-Sánchez, Tobias Reichlin, Christian Mueller
Journal: Circulation (2018)
Rapid Classification of Positive Blood Cultures
Authors: P. Anthony Chapdelaine
Journal: JAMA (1992)

To the Editor.  —In their prospective cohort study, Bates and Lee 1 developed a model that may help in the differentiation of true-positive bacterial cultures from false-positive cultures within 1 day of culture. Their study design avoided most common biases and the use of a logistic function was an appropriate and powerful tool.  There are a few areas that need clarification. In Table 6, Organism category  was identified as an independent predictor of bacteremia and assigned points, yet the 95% confidence interval for the odds ratio crossed one (0.9-17), which indicates nonsignificance. The number of points assigned to Time until blood culture became positive are apparently 8, 6,4, and 2 for 1,2,3, and 4 days, respectively. Also, for Risk category, which is based on clinical-risk score, the points are apparently 0,1, 2, and 3 for groups 1, 2, 3, and 4, respectively. These numbers are important if clinicians are
Impact of organ failure in patients with acute on chronic liver failure (ACLF) and the newly defined AARC liver failure score in predicting 90 days survival-results from APASAL-ACLF research consortium (AARC)
Authors: A. Pande, A. Choudhury, M. Kumar, S. Rahman, H. Deverbhavi, Z. Duan, D.J. Kim, C. Eapen, Q. Ning, Y. Chawla, W. Jafri, S.-S. Tan, H.L. Ghazinyan, D. Amarapurkar, S. Treeprasertsuk, G.H. Lee, J.H. Hu, L.A. Lesmana, A. Shukla, S. Shah, C. Kalal, M. Sahoo, Z. Abbas, S. Joyes, F. Karim, G. Lau, N.R. Padaki, D. Payawal, A. Kadir Dokmeci, V. Saraswat, M.-F. Yuen, V. Gm, O. Yokosuka, A. Shrestha, I. Paulson, P. Jain, G. Kumar, S.K. Sarin
Journal: Journal of Hepatology (2018)
Abstract 16622: Plasma Metabolomic Profiles Differentiate Hemodynamic Subtypes of Pulmonary Hypertension
Authors: Nancy Luo, Damian M Craig, Olga Ilkayeva, James Bain, Michael Muehlbauer, William E Kraus, Christopher B Newgard, Svati H Shah, Sudarshan Rajagopal
Journal: Circulation (2015)

Introduction: Pulmonary hypertension (PH) is defined as a mean pulmonary artery pressures (mPAP) ≥ 25 mmHg. Within PH, there are distinct hemodynamic subgroups based on the presence of hypertension in the precapillary or postcapillary beds of the pulmonary vasculature: pulmonary arterial hypertension (PAH - precapillary PH), passive PH secondary to left heart disease (postcapillary PH) and mixed PH with both precapillary and postcapillary components. Hypothesis: As metabolic abnormalities have been noted in PAH and heart failure, we hypothesized that different hemodynamic subtypes of PH would be associated with distinct plasma metabolomic profiles. Methods: The CATHGEN biorepository consists of biological samples collected on over 9000 individuals undergoing cardiac catheterization at Duke University Medical Center. Of those subjects who had targeted metabolomics studies performed, 282 were identified with mPAP ≥ 25 mmHg. Of these 282 subjects, 133 met criteria for passive PH (PCWP &gt; 15 mmHg, PVR 15 mmHg, PVR ≥ 3 WU) and 67 for PAH (PCWP ≤ 15 mmHg). Tandem flow injection mass spectrometry (MS) with isotope-labeled internal standards were used for targeted quantitative measurements of ~ 60 metabolites (including free fatty acids, acylcarnitines, amino acids, lipids and ketones). Multivariable logistic regression adjusted for age, presence of coronary artery disease, sex, race, diabetes and ejection fraction were used to determine differences in metabolites between the pulmonary HTN subgroups and with a matched cohort of CATHGEN subjects free from PH (N=280, matched on 282). Results: All PH subgroups demonstrated significantly different levels of long chain acylcarnitines from controls (p &lt; 0.01). Compared to controls, subjects with mixed PH also had significant differences in long chain dicarboxyl acylcarnitines (p &lt; 0.01) and C3-C5s (p &lt; 0.028), passive PH had significant differences in ketone related metabolites (p &lt; 0.04), and PAH had significant differences in branched chain amino acids (p &lt; 0.01). Conclusions: Passive, mixed and PAH subtypes of PH were associated with distinct plasma metabolomics profiles compared to matched controls. These finding demonstrate that specific metabolic changess develop in the distinct subtypes of PH.
A Novel Method for the Development of Environmental Public Health Indicators and Benchmark Dose Estimation Using a Health-Based End Point for Chlorpyrifos
Authors: Todd J. Zurlinden, Brad Reisfeld
Journal: Environmental Health Perspectives (2018)

Organophosphorus (OP) compounds are the most widely used group of insecticides in the world. Risk assessments for these chemicals have focused primarily on 10% inhibition of acetylcholinesterase in the brain as the critical metric of effect. Aside from cholinergic effects resulting from acute exposure, many studies suggest a linkage between cognitive deficits and long-term OP exposure.In this proof-of-concept study, we focused on one of the most widely used OP insecticides in the world, chlorpyrifos (CPF), and utilized an existing physiologically based pharmacokinetic (PBPK) model and a novel pharmacodynamic (PD) dose-response model to develop a point of departure benchmark dose estimate for cognitive deficits following long-term, low-dose exposure to this chemical in rodents.Utilizing a validated PBPK/PD model for CPF, we generated a database of predicted biomarkers of exposure and internal dose metrics in both rat and human. Using simulated peak brain CPF concentrations, we developed a dose-response model to predict CPF-induced spatial memory deficits and correlated these changes to relevant biomarkers of exposure to derive a benchmark dose specific to neurobehavioral changes. We extended these cognitive deficit predictions to humans and simulated corresponding exposures using a model parameterized for humans.Results from this study indicate that the human-equivalent benchmark dose (BMD) based on a 15% cognitive deficit as an end point is lower than that using the present threshold for 10% brain AChE inhibition. This predicted human-equivalent subchronic BMD threshold compares to occupational exposure levels determined from biomarkers of exposure and corresponds to similar exposure conditions where deficits in cognition are observed.Quantitative PD models based on neurobehavioral testing in animals offer an important addition to the methodologies used for establishing useful environmental public health indicators and BMDs, and predictions from such models could help inform the human health risk assessment for chlorpyrifos. https://doi.org/10.1289/EHP1743.
Growth and Growth Charts in Children
Authors: Lindsay A. Thompson, Megan A. Moreno
Journal: JAMA Pediatrics (2018)

Growth and Growth Charts in ChildrenGrowth is a result of your child's genetics, environment, and culture.When your children come to a well-child check, their pediatrician will measure their height and weight at each visit and head circumference when they are 3 years and younger.Not only can it be fun to see how much they have grown between visits, but these measurements also provide important information about their health and development.Growth charts can be on paper or in an electronic medical record.These charts are standardized graphs that use information from a larger population to show how your child compares with other children of the same age and sex.Pediatricians are interested in the "percentile" in which your child falls, as well as if your child is tracking along the same percentile over time.For example, if your child is on the 50% percentile, it means that on average, 50% of children of the same age and sex are bigger than your child and 50% are smaller.
Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks
Authors: Anni Sorkio, Lothar Koch, Laura Koivusalo, Andrea Deiwick, Susanna Miettinen, Boris Chichkov, Heli Skottman
Journal: Biomaterials (2018)

There is a high demand for developing methods to produce more native-like 3D corneal structures. In the present study, we produced 3D cornea-mimicking tissues using human stem cells and laser-assisted bioprinting (LaBP). Human embryonic stem cell derived limbal epithelial stem cells (hESC-LESC) were used as a cell source for printing epithelium-mimicking structures, whereas human adipose tissue derived stem cells (hASCs) were used for constructing layered stroma-mimicking structures. The development and optimization of functional bioinks was a crucial step towards successful bioprinting of 3D corneal structures. Recombinant human laminin and human sourced collagen I served as the bases for the functional bioinks. We used two previously established LaBP setups based on laser induced forward transfer, with different laser wavelengths and appropriate absorption layers. We bioprinted three types of corneal structures: stratified corneal epithelium using hESC-LESCs, lamellar corneal stroma using alternating acellular layers of bioink and layers with hASCs, and finally structures with both a stromal and epithelial part. The printed constructs were evaluated for their microstructure, cell viability and proliferation, and key protein expression (Ki67, p63α, p40, CK3, CK15, collagen type I, VWF). The 3D printed stromal constructs were also implanted into porcine corneal organ cultures. Both cell types maintained good viability after printing. Laser-printed hESC-LESCs showed epithelial cell morphology, expression of Ki67 proliferation marker and co-expression of corneal progenitor markers p63α and p40. Importantly, the printed hESC-LESCs formed a stratified epithelium with apical expression of CK3 and basal expression of the progenitor markers. The structure of the 3D bioprinted stroma demonstrated that the hASCs had organized horizontally as in the native corneal stroma and showed positive labeling for collagen I. After 7 days in porcine organ cultures, the 3D bioprinted stromal structures attached to the host tissue with signs of hASCs migration from the printed structure. This is the first study to demonstrate the feasibility of 3D LaBP for corneal applications using human stem cells and successful fabrication of layered 3D bioprinted tissues mimicking the structure of the native corneal tissue.
Safety and Efficacy of Combination Treatment With Calcineurin Inhibitors and Vedolizumab in Patients With Refractory Inflammatory Bowel Disease
Authors: Britt Christensen, Peter R. Gibson, Dejan Micic, Ruben J. Colman, Sarah R. Goeppinger, Olufemi Kassim, Andres Yarur, Christopher R. Weber, Russell D. Cohen, David T. Rubin
Journal: Clinical Gastroenterology and Hepatology (2018)
Sepsis in HBV associated decompensated cirrhosis: A comparison between SIRS (Sepsis-1) and qSOFA (Sepsis-3) based criteria
Authors: Z. Cao, Y. Liu, X. Lu, L. Chen, S. Yin, Z. Li, R. Mo, P. Ren, L. Chen, J. Lu, X. Wang, G. Zhao, W. Tang, X. Xiang, H. Wang, W. Cai, H. Li, Q. Xie
Journal: Journal of Hepatology (2018)
Comment on Li et al. Time Trends of Dietary and Lifestyle Factors and Their Potential Impact on Diabetes Burden in China. Diabetes Care 2017;40:1685–1694
Authors: Anna Vittoria Mattioli, Francesca Coppi, Alberto Farinetti
Journal: Diabetes Care (2018)

We have read with great interest the article by Li et al. (1). We found their conclusion to be important in view of clinical prevention. They found that a high BMI and low intake of whole grains but high intake of refined grains are the most important individual risk factors related to Chinese diabetes burden; low physical activity and high blood pressure also significantly contributed.

Moreover, they reported that intakes of processed meat, red meat, and sugar-sweetened beverages showed increasing trends over time and were responsible for 2.8, 1.8, and 0.5 million diabetes cases, respectively, in 2011.

With reference to the findings reported …