tbuckley/cabot-search huggingface dataset:
Abstract P096: Trends in Heart Disease Mortality Among Mississippi Adults Over a Three Decade Period, 1980 Through 2013
Authors: Vincent L. Mendy, Rodolfo Vargas, Lamees El-sadek, Abigail Gamble
Journal: Circulation (2016)

Background: Heart disease (HD) mortality has declined in Mississippi over recent decades however it remains as the leading cause of death among Mississippians. Trends in Mississippi HD mortality have not been thoroughly explored. This study examined trends in HD mortality from 1980 through 2013 among Mississippi adults (≥ 25 years) and further assessed trends by race and sex. Methods and Results: Data from Mississippi Vital Statistics (1980 through 2013) were used to calculate age-specific HD mortality rates for Mississippi adults. Cases were identified using underlying cause of death codes from the International Classification of Diseases, Tenth Revision (ICD-10), including I00-I09, I11, I13, and I20-I51. Joinpoint software was used to calculate the average annual percent change in HD mortality rates for the overall population and by race, sex, and race and sex. Overall, the age-adjusted HD mortality rates among Mississippi adults decreased by 36.5% between 1980 and 2013 with an average annual percent change of -1.60% (95% CI -2.0 to -1.3). During this period, HD mortality rates decreased annually on average by -1.30% (95% CI -1.98 to -0.69) for black adults; by -1.60% (95% CI -1.74 to -1.46) for white adults; by -1.30% (95% CI -1.5 to -1.1) for all females, and by -1.90% (95% -2.2 to -1.5) for all males. Conclusions: Between 1980 and 2013 a continual decrease in HD mortality among Mississippi adults was observed. Disparities in the magnitude of the decrease in HD mortality existed by race and sex.
Abstract 331: Activation of the Safe Pathway Against Cardiac Ischemia-Reperfusion Injury Goes Beyond the Risk Pathway in the Late Pregnancy
Authors: Jingyuan Li, Mansoureh Eghbali
Journal: Circulation (2014)

Introduction: We have recently shown that the heart of late pregnant (LP) rodent is more prone to ischemia/reperfusion (I/R) injury compared to non-pregnant. We also reported that post-ischemic adminstartion of (ITLD) protects the LP hearts against I/R injury. Here we investigated Survivor Activating Factor Enhancement (SAFE) pathway, which requires the activation of the signal transducer and activator of transcription 3 (STAT-3) and it can successfully lessen cardiomyocyte death at the time of reperfusion, independently of the activation of the already well-described Reperfusion Injury Salvage Kinase (RISK) pathway (which includes activation of phosphoinositide 3-kinase (PI3K) signaling pathways) in ITLD-induced cardioprotetion. Methods: Isolated LP mouse hearts were subjected to 20 min ischemia followed by 40 reperfusion with 1) Krebs Henseleit buffer (CTRL group), 2) 1% intralipid (ITLD group) or 3) ITLD+STAT3 inhibitor Stattic (20 μM, Stattic group), and 4) ITLD+PI3K inhibitor LY294002 (45 μM). Hemodynamics and myocardial infarction were measured. Two-way and one-way ANOVA was used for statistical analysis. The data are from four to six mice in each group. P&lt;0.05 was considered statistically significant. Values are expressed as mean± SE. Results: The Intralipid-induced cardioprotection was only partially abolished by PI3K inhibitor, LY294002, whereas it was fully abolished when stattic was applied at the end of 40 min reperfusion. The RPP was significantly lower in LY294002 treated group compared to the group treated with Intralipid alone, but still significantly higher than ITLD+Stattic: RPP=8881±1331 mmHg*beats/min in ITLD vs. 5212±1955 mmHg*beats/min in ITLD+LY, p&lt;0.05; 1186±563 mmHg*beats/min in ITLD+Stattic vs. 5212±1955 mmHg*beats/min in ITLD+LY, p&lt;0.05. The infarct size was also larger in LY294002 treated group when compared to Intralipid alone (32.8±3.1% in ITLD+LY vs. 21.7±2.6% in ITLD, p&lt;0.05), but lower than ITLD+Stattic group (32.8±3.1% in ITLD+LY vs 47.9±2.5% ITLD+Stattic, p&lt;0.05). Conclusion: Intralipid protects the heart of late pregnant mice against I/R injury mainly through SAFE-STAT3 pathway.
Inflammatory disorders mimicking periprosthetic joint infections may result in false-positive α-defensin
Authors: A. Plate, L. Stadler, R. Sutter, A. Anagnostopoulos, D. Frustaci, R. Zbinden, S.F. Fucentese, A.S. Zinkernagel, P.O. Zingg, Y. Achermann
Journal: Clinical Microbiology and Infection (2018)
Effect of Prostate Cancer Severity on Functional Outcomes After Localized Treatment: Comparative Effectiveness Analysis of Surgery and Radiation Study Results
Authors: Mark Douglas Tyson, Tatsuki Koyama, Dan Lee, Karen E. Hoffman, Matthew J. Resnick, Xiao-Cheng Wu, Matthew R. Cooperberg, Michael Goodman, Sheldon Greenfield, Ann S. Hamilton, Mia Hashibe, Lisa E. Paddock, Antoinette Stroup, Vivien Chen, Ralph Conwill, Dan McCollum, David F. Penson, Daniel A. Barocas
Journal: European Urology (2018)
Clinicians Support Medical Marijuana Use in Children With Cancer, but Lack Knowledge
Authors: Rachel Rabkin Peachman
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel targeted therapies and immunotherapy for advanced thyroid cancers
Authors: George E. Naoum, Michael Morkos, Brian Kim, Waleed Arafat
Journal: Molecular Cancer (2018)

Thyroid cancer is a frequently encountered endocrine malignancy. Despite the favorable prognosis of this disease, 15-20% of differentiated thyroid cancer (DTC) cases and most anaplastic types, remain resistant to standard treatment options, including radioactive iodine (RAI). In addition, around 30% of medullary thyroid cancer (MTC) cases show resistance after surgery. The evolving understanding of disease-specific molecular therapeutic targets has led to the approval of two targeted therapies (Sorafenib and Lenvatinib) for RAI refractory DTC and another two drugs (Vandetanib and Cabozantinib) for MTC. These advanced therapies exert their effects by blocking the MAPK pathway, which has been widely correlated to different types of thyroid cancers. While these drugs remain reserved for thyroid cancer patients who failed all treatment options, their ability to improve patients' overall survival remain hindered by their low efficacy and other molecular factors. Among these factors is the tumor's ability to activate parallel proliferative signaling pathways other than the cascades blocked by these drugs, along with overexpression of some tyrosine kinase receptors (TKR). These facts urge the search for novel different treatment strategies for advanced thyroid cases beyond these drugs. Furthermore, the growing knowledge of the dynamic immune system interaction with tumor microenvironment has revolutionized the cancer immune therapy field. In this review, we aim to discuss the molecular escape mechanisms of thyroid tumors from these drugs. We also highlight novel therapeutic options targeting other pathways than MAPK, including PI3K pathway, ALK translocations and HER2/3 receptors and their clinical impact. We also aim to discuss the usage of targeted therapy in restoring thyroid tumor sensitivity to RAI, and finally turn to extensively discuss the role of immunotherapy as a potential alternative treatment option for advanced thyroid diseases.
Kystogastrostomie sous contrôle échoendoscopique dans le drainage des collections pancréatiques: Expérience d'un service marocain
Authors: H Boutallaka, H Seddik, K Loubaris, A Aomari, F Bouhamou, S Morabit, S Jamal, R Berraida, I El Koti, S Sentissi, A Benkirane
Journal: Endoscopy (2018)

Les pseudokystes du pancréas sont définis selon la conférence de consensus d'Atlanta comme étant des collections de liquide pancréatique entourées d'une paroi de tissu fibreux granuleux dénuées d'épithélium. Les options thérapeutiques disponibles actuellement sont le traitement chirurgical, le drainage radiologique, et le traitement endoscopique. L'objectif de notre étude est d'évaluer les résultats thérapeutiques de la kystogastrostomie guidée par échoendoscopie dans le traitement des pseudokystes du pancréas et de les comparer aux données de la littérature.
Adjuvant vemurafenib in resected, BRAFV600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
Authors: Michele Maio, Karl Lewis, Lev Demidov, Mario Mandalà, Igor Bondarenko, Paolo A Ascierto, Christopher Herbert, Andrzej Mackiewicz, Piotr Rutkowski, Alexander Guminski, Grant R Goodman, Brian Simmons, Chenglin Ye, Yibing Yan, Dirk Schadendorf, Gabriela Cinat, Luis Enrique Fein, Michael Brown, Alexander Guminski, Andrew Haydon, Adnan Khattak, Catriona McNeil, Phillip Parente, Jeremy Power, Rachel Roberts-Thomson, Shahneen Sandhu, Craig Underhill, Suresh Varma, Thomas Berger, Ahmad Awada, Nathalie Blockx, Veronique Buyse, Jeroen Mebis, Fábio André Franke, Sérgio Jobim de Azevedo, Nicolas Silva Lazaretti, Rahima Jamal, Catalin Mihalcioiu, Teresa Petrella, Kerry Savage, Xinni Song, Ralph Wong, Nina Dabelic, Stjepko Plestina, Zeljko Vojnovic, Petr Arenberger, Ivo Kocak, Ivana Krajsova, Eugen Kubala, Bohuslav Melichar, Yvetta Vantuchova, Kadri Putnik, Brigitte Dreno, Caroline Dutriaux, Jean-Jacques Grob, Pascal Joly, Jean-Philippe Lacour, Nicolas Meyer, Laurent Mortier, Luc Thomas, Michael Fluck, Thilo Gambichler, Jessica Hassel, Axel Hauschild, Dirk Schadendorf, Paul Donnellan, John McCaffrey, Derek Power, Samuel Ariad, Gil Bar-Sela, Daniel Hendler, Ilan Ron, Jacob Schachter, Paolo Ascierto, Alfredo Berruti, Luca Bianchi, Vanna Chiarion Sileni, Francesco Cognetti, Riccardo Danielli, Anna Maria Di Giacomo, Luca Gianni, Aron Goldhirsch, Michele Guida, Michele Maio, Mario Mandalà, Paolo Marchetti, Paola Queirolo, Armando Santoro, Ellen Kapiteijn, Andrzej Mackiewicz, Piotr Rutkowski, Paula Ferreira, Lev Demidov, Georgy Gafton, Yulia Makarova, Zoran Andric, Nada Babovic, Darjana Jovanovic, Lidija Kandolf Sekulovic, Graham Cohen, Lydia Dreosti, Daniel Vorobiof, Maria Teresa Curiel Garcia, Roberto Diaz Beveridge, Margarita Majem Tarruella, Ivan Marquez Rodas, Jose-M Puliats Rodriguez, Antonio Rueda Dominguez, Marianne Maroti, Karin Papworth, Olivier Michielin, Igor Bondarenko, Ewan Brown, Pippa Corrie, Mark Harries, Christopher Herbert, Satish Kumar, Agustin Martin-Clavijo, Mark Middleton, Poulam Patel, Toby Talbot, Sanjiv Agarwala, Paul Chapman, Robert Conry, Gary Doolittle, Tara Gangadhar, Sigrun Hallmeyer, Omid Hamid, Leonel Hernandez-Aya, Douglas Johnson, Frederic Kass, Tatjana Kolevska, Karl Lewis, Scott Lunin, April Salama, Branimir Sikic, Bradley Somer, David Spigel, Eric Whitman
Journal: The Lancet Oncology (2018)
Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals
Authors: Aniek C. Bouwman, Hans D. Daetwyler, Amanda J. Chamberlain, Carla Hurtado Ponce, Mehdi Sargolzaei, Flavio S. Schenkel, Goutam Sahana, Armelle Govignon-Gion, Simon Boitard, Marlies Dolezal, Hubert Pausch, Rasmus F. Brøndum, Phil J. Bowman, Bo Thomsen, Bernt Guldbrandtsen, Mogens S. Lund, Bertrand Servin, Dorian J. Garrick, James Reecy, Johanna Vilkki, Alessandro Bagnato, Min Wang, Jesse L. Hoff, Robert D. Schnabel, Jeremy F. Taylor, Anna A. E. Vinkhuyzen, Frank Panitz, Christian Bendixen, Lars-Erik Holm, Birgit Gredler, Chris Hozé, Mekki Boussaha, Marie-Pierre Sanchez, Dominique Rocha, Aurelien Capitan, Thierry Tribout, Anne Barbat, Pascal Croiseau, Cord Drögemüller, Vidhya Jagannathan, Christy Vander Jagt, John J. Crowley, Anna Bieber, Deirdre C. Purfield, Donagh P. Berry, Reiner Emmerling, Kay-Uwe Götz, Mirjam Frischknecht, Ingolf Russ, Johann Sölkner, Curtis P. Van Tassell, Ruedi Fries, Paul Stothard, Roel F. Veerkamp, Didier Boichard, Mike E. Goddard, Ben J. Hayes
Journal: Nature Genetics (2018)
<i>Vital Signs</i>: Asthma in Children — United States, 2001–2016
Authors: Hatice S. Zahran, Cathy M. Bailey, Scott A. Damon, Paul L. Garbe, Patrick N. Breysse
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

Asthma is the most common chronic lung disease of childhood, affecting approximately 6 million children in the United States. Although asthma cannot be cured, most of the time, asthma symptoms can be controlled by avoiding or reducing exposure to asthma triggers (allergens and irritants) and by following recommendations for asthma education and appropriate medical care.CDC analyzed asthma data from the 2001-2016 National Health Interview Survey for children aged 0-17 years to examine trends and demographic differences in health outcomes and health care use.Asthma was more prevalent among boys (9.2%) than among girls (7.4%), children aged ≥5 years (approximately 10%) than children aged <5 years (3.8%), non-Hispanic black (black) children (15.7%) and children of Puerto Rican descent (12.9%) than among non-Hispanic white (white) children (7.1%), and children living in low income families (10.5%) than among those living in families with income ≥250% of the Federal Poverty Level (FPL) (approximately 7%). Asthma prevalence among children increased from 8.7% in 2001 to 9.4% in 2010, and then decreased to 8.3% in 2016. Although not all changes were statistically significant, a similar pattern was observed among subdemographic groups studied, with the exception of Mexican/Mexican-American children, among whom asthma prevalence increased from 5.1% in 2001 to 6.5% in 2016. Among children with asthma, the percentage who had an asthma attack in the past 12 months declined significantly from 2001 to 2016. Whereas asthma prevalence was lower among children aged 0-4 years than among older children, the prevalence of asthma attacks (62.4%), emergency department or urgent care center (ED/UC) visits (31.1%), and hospitalization (10.4%) were higher among children with asthma aged 0-4 years than among those aged 12-17 years (44.8%, 9.6%, and 2.8%, respectively). During 2013, children with asthma aged 5-17 years missed 13.8 million days of school per year (2.6 days per child). Compared with 2003, in 2013, the prevalence of adverse health outcomes and health care use were significantly lower and the prevalence of having an action plan to manage asthma was higher.Asthma remains an important public health and medical problem. The health of children with asthma can be improved by promoting asthma control strategies, including asthma trigger reduction, appropriate guidelines-based medical management, and asthma education for children, parents, and others involved in asthma care.
Effects of diltiazem and nitroglycerin on prostaglandin F2.ALPHA.-induced periodic contractions of isolated human coronary arteries.
Authors: Ken-Ichi Kawasaki, Katumi Seki, Isao Miyazawa, Naohiro Matumoto, Norifumi Nakanisi, Tomoya Iino, Saichi Hosoda
Journal: Circulation (1985)
Taux de détection des adénomes et risque de cancer d'intervalle après coloscopie dans le programme français de dépistage organisé en Isère de 2002 – 2013
Authors: C Exbrayat, A Seigneurin, P Jennings
Journal: Endoscopy (2018)

Le cancer colorectal est le troisième cancer le plus souvent diagnostiqué chez les hommes et le deuxième chez les femmes, avec 1.4 million de nouveaux cas et 693 000 décès en 2012 dans le monde.
Assessing Metronomic Chemotherapy for Progressive Pediatric Solid Malignant Tumors
Authors: Shripad Banavali, Kumar Prabhash, Vijay Patil
Journal: JAMA Oncology (2018)

To the Editor First of all, we congratulate Pramanik et al1 for carrying out the first randomized clinical trial in the field of metronomic chemotherapy. However, we would like to raise some pertinent issues.
Corrélation et facteurs prédictifs de concordance entre endoscopie histologie au cours de l'endobrachyoesophage: à propos de 150 cas
Authors: R Kallel, M Sabbah, N Bibani, D Trad, H Elloumi, A Ouakaa-Kchaou, J Kharrat, D Gargouri
Journal: Endoscopy (2018)

Le diagnostic d'endobrachyoesophage (EBO) est suspecté endoscopiquement et confirmé histologiquement. Le but de ce travail était d'étudier la corrélation entre l'endoscopie et l'histologie dans le diagnostic positif d'EBO et de rechercher les facteurs prédictifs de concordance.
Absolute vs Additive Net Reclassification Index
Authors: Maarten J. G. Leening, Michael J. Pencina
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTH-064 Longitudinal investigation of microbiota dynamics in a model of mild chronic dss-induced colitis in wild-type (wt) c57bl/6 mice receiving diets with different iron contents
Authors: A Mahalhal, B Campbell, DM Pritchard, C Probert
Journal: Gut (2017)

Introduction  Iron deficiency anaemia is common in inflammatory bowel disease (IBD). Iron supplementation may induce or exacerbate colitis in rats (APT 2001;15:1989–99). Dysbiosis is common in IBD and iron contributes to this as it is a growth factor for some bacteria. We examined the long-effect of dietary iron supplementation and iron reduction on the intestinal microbiome in a chronic murine model of colitis. We report results of changes at the phylum level.  Method  Studies were performed on 6 groups of 8 WT mice. Chronic colitis was induced with 1.25% dextran sodium sulphate (DSS) for 5 days, followed by 16 further days on water [for three consecutive cycles]. DSS-treated mice were fed one of three diets (start from day-1 of experiments): low iron [LI] (100ppm), normal iron [NI] (200ppm) and high iron [HI] (400ppm) supplemented chow. Also, three non-DSS-treated groups were studied and fed similarly. Half of the mice in each control group were treated with one cycle of acute 2% DSS for 5 days at day 53, followed by 5 further days on water.All mice were sacrificed at day 63. Clinical and pathological data were compared at day-1, 21, 42 and 63 (chronic) and day-1 and 10 (acute); bacterial gDNA was extracted from faeces and microbiota composition determined from the sequence of V4 region of 16S rDNA on the Illumina MiSeq platform. Statistical inferences were made using Kruskal-Wallis H-test with post-hoc analysis (Bioinformatics 2010;26:715–21).  Results  DSS-induced colitis in all treated mice. Chronic DSS colitis was not associated with significant weight loss, while weight loss in acute DSS mice was greatest in the LI diet group (p  Conclusion  Changes in nutritional luminal iron exacerbate colitis. Oral administration of DSS causes a reproducible acute colitis, followed by a slow recovery phase with a concomitant chronic inflammation. Chronic colitis was worse in mice fed low or high iron diets. Dysbiosis was found in mice with chronic colitis and altered iron intake as well as controls receiving high iron diets. Iron, therefore, appears to contribute to the dysbiosis associated with IBD.  Disclosure of Interest  None Declared
Palatal prolapse as a signature of expiratory flow limitation and inspiratory palatal collapse in patients with obstructive sleep apnoea
Authors: Ali Azarbarzin, Scott A. Sands, Melania Marques, Pedro R. Genta, Luigi Taranto-Montemurro, Ludovico Messineo, David P. White, Andrew Wellman
Journal: European Respiratory Journal (2018)

In some individuals with obstructive sleep apnoea (OSA), the palate prolapses into the velopharynx during expiration, limiting airflow through the nose or shunting it out of the mouth. We hypothesised that this phenomenon causes expiratory flow limitation (EFL) and is associated with inspiratory “isolated” palatal collapse. We also wanted to provide a robust noninvasive means to identify this mechanism of obstruction. Using natural sleep endoscopy, 1211 breaths from 22 OSA patients were scored as having or not having palatal prolapse. The patient-level site of collapse (tongue-related, isolated palate, pharyngeal lateral walls and epiglottis) was also characterised. EFL was quantified using expiratory resistance at maximal epiglottic pressure. A noninvasive EFL index (EFLI) was developed to detect the presence of palatal prolapse and EFL using the flow signal alone. In addition, the validity of using nasal pressure was assessed. A cut-off value of EFLI &gt;0.8 detected the presence of palatal prolapse and EFL with an accuracy of &gt;95% and 82%, respectively. The proportion of breaths with palatal prolapse predicted isolated inspiratory palatal collapse with 90% accuracy. This study demonstrates that expiratory palatal prolapse can be quantified noninvasively, is associated with EFL and predicts the presence of inspiratory isolated palatal collapse.