tbuckley/cabot-search huggingface dataset:
Re: James T. Kearns, Anna V. Faino, Lisa F. Newcomb, et al. Role of Surveillance Biopsy with No Cancer as a Prognostic Marker for Reclassification: Results from the Canary Prostate Active Surveillance Study. Eur Urol 2018;73:706–12
Authors: Runqiang Yuan
Journal: European Urology (2018)
Abstract 17287: Difference in the Maintenance Mechanism Between the Paroxysmal and Persistent Atrial Fibrillation: Three-dimensional Analysis Using a Non-contact Mapping System
Authors: Shozo Kaneko, Hiroshige Yamabe, Hisanori Kanazawa, Miwa Ito, Yusuke Kanemaru, Takuya Kiyama, Hisao Ogawa
Journal: Circulation (2016)

Introduction: Pulmonary vein isolation has been effective in the treatment of paroxysmal atrial fibrillation (AF). However, ablation response rate remains lower in persistent AF. Furthermore, the d...
Better political and legal protection to improve sex workers’ health
Authors: John Reynolds-Wright, Sandy Goldbeck-Wood
Journal: BMJ (2018)

Protection for sex workers needs to include access to contraception and maternity services. Health interventions need to be underpinned by the right political and legal framework.

Howard emphasises the importance of sexual and reproductive rights for sex workers in the UK and the need to prevent sexually transmitted infections and sexual violence.1 Policies that actively …
Michael Kenneth Weaver
Authors: Denise Adams, Nicola Hirschauer, David Mayne
Journal: BMJ (2018)

Michael Kenneth Weaver (“Mike”) trained in anaesthesia at the Northern School of Anaesthesia, followed by a period of post-CCT specialist training in paediatric anaesthesia in Pittsburgh, USA. He was appointed consultant at the Queen Elizabeth Hospital in Gateshead in 1996. As college tutor and clinical director, he developed a modern department that remains one of the most popular training …
Comatose 62-Year-Old Woman Following Cardiopulmonary Resuscitation
Authors: Kan Liu, Megha Dogra
Journal: JAMA Cardiology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Continuous positive airway pressure effect on visual acuity in patients with type 2 diabetes and obstructive sleep apnoea: a multicentre randomised controlled trial
Authors: Sophie D. West, Benjamin Prudon, Joan Hughes, Rajen Gupta, Seid B. Mohammed, Stephen Gerry, John R. Stradling
Journal: European Respiratory Journal (2018)

We sought to establish whether continuous positive airway pressure (CPAP) for obstructive sleep apnoea (OSA) in people with type 2 diabetes and diabetic macular oedema (DMO) improved visual acuity. We randomly assigned 131 eligible patients aged 30–85 years from 23 UK centres with significant DMO causing visual impairment (LogMAR letters identified ≥39 and ≤78, score 0.92–0.14) plus severe OSA on screening to either usual ophthalmology care (n=67) or usual ophthalmology care plus CPAP (n=64) for 12 months. Mean age of participants was 64 years, 73% male, mean body mass index 35.0 kg·m − 2 . Mean 4% oxygen desaturation index was 36 events·h −1 . There was no significant difference in the visual acuity at 12 months between the CPAP group and the control group (mean LogMAR 0.33 (95% CI 0.29–0.37) versus 0.31 (95% CI 0.27–0.35); p=0.39), and no significant correlation between change in LogMAR and average CPAP use. The median± sd (range) daily CPAP use was 3.33±2.25 (0–7.93) h at 3 months, 3.19±2.54 (0–8.07) h at 6 months and 3.21±2.70 (0–7.98) h at 12 months. CPAP therapy for OSA did not improve visual acuity in people with type 2 diabetes and DMO compared with usual care alone over 12 months.
68Ga-PSMA Uptake in Angiolipoma
Authors: Irma Dekker, Marloes van der Leest, Maartje C. van Rijk, Winald R. Gerritsen, Anne I. J. Arens
Journal: Clinical Nuclear Medicine (2018)

Abstract 68 Ga-PSMA PET/CT is an imaging technique used in staging and detection of prostate cancer. However, enhanced uptake on 68 Ga-PSMA PET/CT scan has also been ascribed to other malignant and benign lesions. We report on a case of a 56-year-old man with treated prostate carcinoma who had a 68 Ga-PSMA PET/CT scan for restaging. 68 Ga-PSMA uptakes in the prostatic bed and in multiple subcutaneous lesions were seen. Histopathology of a subcutaneous lesion revealed angiolipoma. It is important to be aware of the existence of the growing amount of reports on enhanced 68 Ga-PSMA uptake unrelated to prostate cancer.
Richard Emmott Shaw
Authors: Rob Blacklock
Journal: BMJ (2018)

Richard Emmott Shaw was born in Ravensthorpe in the West Riding of Yorkshire. He came from a family of corn millers. Educated at Mirfield Grammar School, he then studied medicine at Leeds University. After surgical appointments on the professorial unit at Leeds General Infirmary and as RSO at the Dewsbury and District Infirmary, he was called up for military service in the Royal Army Medical Corps. He initially served as medical officer to an infantry unit in Norfolk, where he met his future wife, Jean Duncan Hart. He then went off to North Africa as surgical specialist to military hospitals in Algeria and later to Europe. He married Jean on 17 August 1945 at North Walsham. Soon after, he was dispatched to Kenya for two years (Nairobi and Mombasa). A careful reading of the regulations persuaded him that he was entitled to …
Abstract 19286: Human Cardiac Progenitors Isolated From Young Donors Harbor a Less Mature Phenotype Compared to Progenitors From Adult Donors
Authors: Ann-Sophie Walravens, Lara Ottaviani, Maarten Vanhaverbeke, Hilde Gillijns, Nina Vanden Driessche, Sander Trenson, Aernout Luttun, Jens-Uwe Voigt, Bart Meyns, Paul Herijgers, Filip Rega, Bart Meuris, Ruth Heying, Maurilio Sampaolesi, Stefan Janssens
Journal: Circulation (2016)

Introduction: Resident cardiac progenitor populations induce regeneration after myocardial infarction. Here we compare c-kitpos cardiac progenitor cells (CPC) and cardiosphere-derived cells (CDC) t...
Effect of ambulatory oxygen on quality of life for patients with fibrotic lung disease (AmbOx): a prospective, open-label, mixed-method, crossover randomised controlled trial
Authors: Dina Visca, Letizia Mori, Vicky Tsipouri, Sharon Fleming, Ashi Firouzi, Matteo Bonini, Matthew J Pavitt, Veronica Alfieri, Sara Canu, Martina Bonifazi, Cristina Boccabella, Angelo De Lauretis, Carmel J W Stock, Peter Saunders, Andrew Montgomery, Charlotte Hogben, Anna Stockford, Margaux Pittet, Jo Brown, Felix Chua, Peter M George, Philip L Molyneaux, Georgios A Margaritopoulos, Maria Kokosi, Vasileios Kouranos, Anne Marie Russell, Surinder S Birring, Alfredo Chetta, Toby M Maher, Paul Cullinan, Nicholas S Hopkinson, Winston Banya, Jennifer A Whitty, Huzaifa Adamali, Lisa G Spencer, Morag Farquhar, Piersante Sestini, Athol U Wells, Elisabetta A Renzoni
Journal: The Lancet Respiratory Medicine (2018)
Association between a PDCD1 polymorphism with renal manifestations in systemic lupus erythematosus
Authors: M Johansson, L Arlestig, B Moller, Solbritt Rantapää-Dahlqvist
Journal: Annals of the Rheumatic Diseases (2005)

Association between a PDCD1 polymorphism with renal manifestations in systemic lupus erythematosus
Abstract 18053: Prognostic Value of Anatomic versus Functional Diagnostic Testing in Symptomatic Patients With Suspected CAD: The PROMISE Trial (PROspective Multicenter Imaging Study for Evaluation of Chest Pain)
Authors: Udo Hoffmann, Maros Ferencik, James E Udelson, Michael H Picard, John Heitner, Manesh R Patel, Megan Huang, Michael Pencina, Daniel B Mark, Christopher B Fordyce, Jean-Claude Tardif, Matthew Budoff, George Nahhas, Benjamin Chow, Andrzej S Kosinski, Kerry L Lee, Pamela S Douglas
Journal: Circulation (2015)

Introduction: Symptoms suggestive of coronary artery disease (CAD) are common, but no randomized comparison of the prognostic value of coronary computed tomographic angiography (CTA) vs. functional testing has been performed. Methods: Patients (10,003) with suspected CAD were randomized to functional testing (exercise ECG, nuclear stress, or stress echo) or CTA. Site-based diagnostic test reports were classified as normal or mildly, moderately, or severely abnormal. Cox proportional hazards models assessed the relationship of test results to a composite of time to death, myocardial infarction, or unstable angina, and the discriminatory ability of the two tests was compared using the C-index. Adjusted HRs for events in patients with abnormal vs. normal test results were determined for CTA and functional testing. Results: Overall, 4516 patients received CTA and 4572 functional testing as the randomized diagnostic test. The proportions of normal, mild, moderate, and severe abnormalities on CTA were 33.3%, 42.7%, 10.0%, and 14.0%, respectively, and for functional testing 78.9%, 8.5%, 4.2%, and 8.4% (P=0.001). Event rates over 26.0 months’ (IQR 18.0, 34.4) follow-up were similar: CTA 137/4516 (3.0%) vs. functional 132/4572 (2.9%). Compared to patients with normal CTAs, those with abnormal CTAs had increasing HRs for events with increasingly severe abnormalities, while only patients with moderate and severely abnormal functional testing had an increased HR for events (Figure). The probability of having an event given a normal test result was lower for CTA compared to functional testing (0.9% vs. 2.2%; HR 0.47 [95% CI 0.26, 0.83]; P=0.009), but not significantly different for other test strata. The overall prognostic performance (C-index) of CTA vs. functional testing was 0.72 (0.68, 0.76) vs. 0.64 (0.60, 0.69); P=0.022 (see KM curves in Figure). Conclusions: In symptomatic patients with suspected CAD, CTA has better prognostic value than functional testing.
Abstract 17007: Racial Trends in Angiographic Evaluation and Revascularization for Non-ST Segment Myocardial Infarction: The Atherosclerosis Risk in Communities Surveillance Study
Authors: Sameer Arora, Kunihiro Matsushita, Arman Qamar, Muthiah Vaduganathan, Harmony R Reynolds, Sripal Bangalore, Melissa C Caughey
Journal: Circulation (2017)

Introduction: Important racial disparities exist in the management of non ST-segment elevation myocardial infarction (NSTEMI). Whether such disparities have mitigated over time is uncertain. Hypothesis: Racial disparities in angiographic evaluation and revascularization for patients with NSTEMI have persisted. Methods: Since 1987, the ARIC Study has conducted hospital surveillance of acute myocardial infarction in 4 US areas (MD, MN, MS, and NC). Clinical data and procedures were abstracted from the medical record. NSTEMI was classified with a validated algorithm. Relative probabilities of angiography and revascularization outcomes were derived from logistic regression, by comparing white to black patients with adjustment for age, sex, TIMI risk score, and hospital geographic region. All analyses were weighted by the sampling fraction. Results: From 1987-2013, 9,525 blacks and 21,721 whites were hospitalized with NSTEMI. Black patients were more often female (45% vs. 35%) and younger (60 vs. 65 years). Fo...
Methods for High-Resolution Electrical Mapping in the Gastrointestinal Tract
Authors: Gregory O'Grady, Timothy R. Angeli, Niranchan Paskaranandavadivel, Jonathan C. Erickson, Cameron I. Wells, Armen A. Gharibans, Leo K. Cheng, Peng Du
Journal: IEEE Reviews in Biomedical Engineering (2018)

Over the last two decades, high-resolution (HR) mapping has emerged as a powerful technique to study normal and abnormal bioelectrical events in the gastrointestinal (GI) tract. This technique, adapted from cardiology, involves the use of dense arrays of electrodes to track bioelectrical sequences in fine spatiotemporal detail. HR mapping has now been applied in many significant GI experimental studies informing and clarifying both normal physiology and arrhythmic behaviors in disease states. This review provides a comprehensive and critical analysis of current methodologies for HR electrical mapping in the GI tract, including extracellular measurement principles, electrode design and mapping devices, signal processing and visualization techniques, and translational research strategies. The scope of the review encompasses the broad application of GI HR methods from in vitro tissue studies to in vivo experimental studies, including in humans. Controversies and future directions for GI mapping methodologies are addressed, including emerging opportunities to better inform diagnostics and care in patients with functional gut disorders of diverse etiologies.
Abstract 13841: The Impact of Age on Coronary Perfusion, Cardiac Function and Inflammation in a Rat Model of Ashpyxial Cardiac Arrest
Authors: Niels Secher, Leif Østergaard, Else Tønnesen, Asger Granfeldt
Journal: Circulation (2015)

Introduction: Age is an independent predictor of poor outcome after cardiac arrest (CA), and age reduces organ function and increase infarct size, oxidative stress and inflammation in studies of regional ischemia reperfusion injury. Meanwhile, experimental CA studies are mostly performed in young, healthy animals, and our understanding of the CA pathophysiology may therefore fail to address the age-effects inherent to human CA. Objective: To investigate whether high age affects the reduction in cardiac function, increased inflammation, and endothelial activation observed after CA. Method: Aged (26 months, n=12) and young (5 months, n=10) male Sprague Dawley rats were subjected to 8 min of asphyxia induced CA, resuscitated using adrenalin and mechanical CPR, and observed for 360 min. Coronary perfusion pressure (CPP) was measured during CPR, and left ventricular end diastolic pressure, dP/dtmax, and dP/dtmin were determined at baseline and at the end of follow up. Blood samples at baseline, 120min, and 360min after CA were analysed for IL-6, IL-10, elastase, sE-selectin, and sI-CAM1. Results: We found no difference in CPP (aged: 16 [95%CI 13;20] vs young: 23 [95%CI 12;34]) or rate of ROSC (aged: 9/12 vs. young 9/10) between groups. During the first hour after resuscitation, a hyperperfusion phase was seen in the young group but not in the aged group (MAP aged: 50mmHg [95%CI 38;62] vs MAP young 105 [95%CI 88;123]). Left ventricular end diastolic pressure and dP/dtmax was higher in aged animals at baseline (p&lt;0.02). We observed a significant decrease in dP/dtmax and increase in dP/dtmin after CA, with no group difference. Compared to young rats, aged animals showed a significantly higher increase in plasma elastase and sE-selectin levels after CA. In contrast, plasma IL-6 and IL-10 increased from baseline to end of follow up, but with no difference between the groups. sI-CAM1 showed no difference over time or between groups. Conclusion: We found increased endothelial activation and a blunted hyperperfusion in aged compared to young rats after CA. Age did not affect cardiac function and cytokine levels.
Abstract 19792: Obesity is Associated With Significantly Higher Healthcare Expenditures in a Large US Employee Population: The Baptist Health South Florida Employee Study
Authors: Chukwuemeka U Osondu, Ehimen C Aneni, Joseph Salami, Javier Valero-Elizondo, Maribeth Rouseff, Sankalp Das, Lara Roberson, Janisse Post, Theodore Feldman, Emir Veledar, Arthur S Agatston, Khurram Nasir
Journal: Circulation (2016)

Introduction: Obesity is a recognized epidemic in the United States (US) and places a huge burden on the US economy and healthcare resources. In this study, we estimate impact of increasing burden ...
Undiagnosed Chagas disease is causing sudden cardiac deaths, warns American Heart Association
Authors: Owen Dyer
Journal: BMJ (2018)

Chagas disease, a chronic parasitic infection that can damage the heart, is widespread in the US and is a frequent cause of sudden cardiac death but often goes undiagnosed by physicians, the American Heart Association has warned.

More than 300 000 people in the US each year are infected by the protozoan causing Chagas disease, Trypanosoma cruzi , the association warned in a scientific statement in the journal Circulation .1 About a third of infected people eventually develop overt heart disease because of the damage done by the parasite. A further 10% develop chronic neurological or gastrointestinal complications.

The vector is the bloodsucking triatomine insect or kissing bug, a name given because of its tendency to bite the face, especially around the mouth. …
Abstract 17258: Effects of Aerobic Exercise Intensity on Ambulatory Blood Pressure Monitoring and Vascular Responses in Resistant Hypertension: A Cross-over Trial
Authors: Lucas Porto Santos, Ruy S Moraes, Paulo J Vieira, Gustavo Waclavowsky, Daniel Umpierre
Journal: Circulation (2015)

Introduction: Patients with resistant hypertension are usually exposed to poor blood pressure (BP) control, resulting in clinical vulnerability, possibility of device-based procedures (denervation), and cumulative costs with drug therapy. Regular aerobic exercise promotes marked benefits in hypertension, including the subset of resistant patients. However, little is known about acute effects of exercise on patients with resistant hypertension. Hypothesis: We hypothesized that a single aerobic session would reduce BP and improve vascular variables. Thus, we compared ambulatory BP and vascular parameters in response to two intensities of aerobic sessions and a non-exercise control session in patients with resistant hypertension. Methods: After a maximal exercise test, 18 patients (54±6 years, 30.2±4.9 kg/m2) participated in three interventions in random order, crossover design, and on separate days: control session (45’ of rest), light intensity (LI) and moderate intensity (MI) sessions (45’ of aerobic exercise at 50% and 75% of HRmax, respectively). Ambulatory BP monitoring (Space Labs, 90702) comprised a 19h period after each session. Vascular variables were measured at the non-dominant forearm by venous occlusion plethysmography (Hokanson Inc) before and up to 1h after all sessions. Results: Compared with control session, both exercise sessions reduced ambulatory systolic BP in a 5h period (LI: -7.7±2.4mm Hg and MI: -9.4±2.8mm Hg, p&lt;0.01), whereas only LI session reduced diastolic BP (-5.7±2.2mm Hg, p&lt;0.01). In addition, LI induced lower values in systolic and diastolic BP during 10h-daytime (-3.8±1.3mm Hg and -4.0±1.3mm Hg, respectively, p&lt;0.02), nighttime (-6.0±2.4 mm Hg and -6.1±1.6mm Hg, respectively, p&lt;0.05) and in diastolic BP during 19h (-4.8±1.2mm Hg, p&lt;0.01). Forearm blood flow decreased only at minute 50 after LI (p&lt;0.05), with no other changes. In control and LI sessions, forearm vascular resistance increased at the end of 1h recovery period and in MI session, it decreased immediately after the intervention (p&lt;0.05). Conclusions: A single aerobic exercise session in light or moderate intensities induces beneficial changes in ambulatory BP in resistant hypertension, with advantages in effect length for lighter intensities.
Abstract 21040: MicroRNA-144 Antagonism Promotes Regression of Atherosclerosis
Authors: Elizabeth J Tarling, Joan Cheng, Angela Cheng, Judy Wu, Tamer Sallam, Angel Baldan, Thomas Q de Aguiar Vallim
Journal: Circulation (2017)

Introduction: Removal of cholesterol from atherosclerotic lesions remains an unmet therapeutic need. The ATP Binding Cassette Transporter A1 (ABCA1) plays a key role in the efflux of cholesterol from macrophages, therefore strategies that increase macrophage ABCA1 levels are likely to be atheroprotective. Methods and Results: To determine the long-term efficacy of anti-microRNA-144 (miR-144) therapy on the progression of atherosclerosis, we first treated Ldlr -/- mice with saline, control anti-miR, or anti-miR-144 oligonucleotides once a week for 16 weeks. Second, to determine the potential of miR-144 antagonism as an interventional atherosclerosis therapeutic, we treated Low-density lipoprotein receptor null ( Ldlr -/- ) mice with established atherosclerotic plaques with anti-miR-144 for 4 weeks, in a model of atherosclerosis regression. All anti-miR-144-treated mice showed an increase in circulating high-density lipoprotein (HDL) levels. In the model of atherosclerosis regression, anti-miR-144-treated mice also showed enhanced reverse cholesterol transport to the plasma, liver, and feces. Consistent with these observations, anti-miR-144-treated mice showed reductions in atherosclerotic burden. Notably, in addition to increasing circulating HDL levels and reverse cholesterol transport, miR-144 antagonism significantly remodeled the HDL particle proteome in both progression and regression models of atherosclerosis. Conclusions: These studies establish that raising HDL levels and altering HDL particle properties by anti-miR-144 treatment promotes reverse cholesterol transport and atherosclerosis regression, and suggest it may be a promising interventional therapeutic strategy to treat atherosclerotic disease.
Cyclodextrin/chitosan nanoparticles for oral ovalbumin delivery: Preparation, characterization and intestinal mucosal immunity in mice
Authors: Muye He, Chen Zhong, Huibing Hu, Yu Jin, Yanzuo Chen, Kaiyan Lou, Feng Gao
Journal: Asian Journal of Pharmaceutical Sciences (2018)

A novel oral protein delivery system with enhanced intestinal penetration and improved antigen stability based on chitosan (CS) nanoparticles and antigen-cyclodextrin (CD) inclusion complex was prepared by a precipitation/coacervation method. Ovalbumin (OVA) as a model antigen was firstly encapsulated by cyclodextrin, either β-cyclodextrin (β-CD) or carboxymethyl-hydroxypropyl-β-cyclodextrin (CM-HP-β-CD) and formed OVA-CD inclusion complexes, which were then loaded to chitosan nanoparticles to form OVA loaded β-CD/CS or CM-HP-β-CD/CS nanoparticles with uniform particle size (836.3 and 779.2 nm, respectively) and improved OVA loading efficiency (27.6% and 20.4%, respectively). In vitro drug release studies mimicking oral delivery condition of OVA loaded CD/CS nanoparticles showed low initial releases at pH 1.2 for 2 h less than 3.0% and a delayed release which was below to 30% at pH 6.8 for further 72 h. More importantly, after oral administration of OVA loaded β-CD/CS nanoparticles to Balb/c mice, OVA-specific sIgA levels in jejunum of OVA loaded β-CD/CS nanoparticles were 3.6-fold and 1.9-fold higher than that of OVA solution and OVA loaded chitosan nanoparticles, respectively. In vivo evaluation results showed that OVA loaded CD/CS nanoparticles could enhance its efficacy for inducing intestinal mucosal immune response. In conclusion, our data suggested that CD/CS nanoparticles could serve as a promising antigen-delivery system for oral vaccination.