tbuckley/cabot-search huggingface dataset:
Abstract 14077: Percutaneous Coronary Intervention of Totally Occluded Venous Bypass Grafts: An Exercise in Futility?
Authors: Michael P Savage, Evan Nardone, David L Fischman, Matthew DeCaro, Nicholas J Ruggiero, Paul Walinsky, Brandon M Madsen, Melissa McCarey
Journal: Circulation (2016)

Introduction: Percutaneous coronary intervention (PCI) of diseased saphenous vein grafts (SVG) continues to be a clinical challenge. Current PCI guidelines give a class III recommendation against p...
Results of two phase I dose escalation studies of the oral heat shock protein 90 (Hsp90) inhibitor SNX-5422.
Authors: Todd Michael Bauer, Jeffrey R. Infante, Ramesh K. Ramanathan, Glen Weiss, Jasgit C. Sachdev, Howard A. Burris, James M Hinson, Everardus O Orlemans
Journal: Journal of Clinical Oncology (2013)

2617 Background: SNX-5422 is a prodrug of SNX-2112, a highly potent, non-geldanamycin analog, HSP90 inhibitor with preclinical anti-tumor activity in multiple tumor models. These phase 1 studies were designed to evaluate safety and tolerability, determine dose limiting toxicities, maximum tolerated doses (MTDs), and describe pharmacokinetics of SNX-2112 and SNX-5422. Methods: Two phase 1, open-label, 3 + 3 dose-escalation studies evaluated SNX-5422 when given daily (QD) or every-other-day (QOD) during the first 30 days of treatment in patients (pts) with advanced solid tumors or lymphoma. Plasma concentrations of SNX-2112 and SNX-5422 were measured after the first and 11 th (steady state) doses. Tumor assessments were performed every 8 weeks. Results: In both studies, pts received SNX-5422 QOD, 3 wks on/1 wk off, with doses ranging from 4 to 133 mg/m 2 QOD. In one study, pts also received QD doses from 50 to 89 mg/m 2 , 3 wks on/1 wk off, and 50 mg/m 2 QD continuously. Fifty-six pts (34M/22F; mean age 62 years) were enrolled. Treatment-related adverse events were mainly low grade (G), including diarrhea (64%), nausea (39%), vomiting (29%), fatigue (27%), abdominal pain (14%), and anorexia (14%). Reversible G 1 blurry vision, and G 1-2 blurry vision/vision darkening were reported by 1 pt on 100 mg/m 2 QOD, and 4 pts treated with 50 to 89 mg/m 2 QD. G 3 diarrhea was dose limiting in 2 of 3 pts (89 mg/m 2 QD; 133 mg/m 2 QOD). MTDs for the QOD and QD schedules were declared at100 mg/m 2 and 67 mg/m 2 , respectively. The QD schedule was associated with higher incidences of treatment related adverse events. 38 pts were evaluable for response including 1 confirmed durable complete response, 1 unconfirmed partial response, and 17 with stable disease. Activity was seen in adrenal, lung, liver, neuroendocrine, GIST, and prostate. All but 2 were seen with the QOD schedule. Conclusions: SNX-5422 mono-therapy was generally well tolerated and showed promising signs of efficacy in pts with advanced solid tumors. Given the superior benefit-risk profile of QOD dosing over QD dosing based on these preliminary clinical findings, 100 mg/m 2 QOD has been selected for further clinical testing. Clinical trial information: NCT00506805 and NCT01611623.
Abstract 16261: Longitudinal Study of Alcohol Consumption and High-Density Lipoprotein Concentrations: A Community-Based Study
Authors: Shue Huang, Junjuan Li, Gregory C Shearer, Alice H Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao
Journal: Circulation (2016)

Introduction:  Cross-sectional studies and short-term clinical trials suggest a linear relationship between alcohol consumption and high-density lipoprotein (HDL) cholesterol concentrations although prospective data suggests the relationship may be more complex. The association between consumption of alcohol and individual alcohol beverages and longitudinal change in HDL concentrations was examined in a community-based cohort.   Methods:  This study included 80,081 Chinese adults (mean age 49 y) who were free of cardiovascular diseases and cancer, and did not use any cholesterol-lowering agents during follow-up. Alcohol intake was assessed by a questionnaire in 2006 (baseline) and participants were categorized as never, past, light (women: 0-0.4 servings/d, men: 0-0.9 servings/d), moderate (women: 0.5-1.0 servings/d, men: 1-2 servings/d), and heavy drinkers (women: >1.0 servings/d, men: >2 servings/d). HDL concentrations were measured in 2006, 2008, 2010, and 2012. We used generalized estimating equation models to examine the associations between baseline alcohol intake and change in HDL concentrations, adjusting for age, sex, smoking, physical activity, obesity, hypertension, diabetes, liver function and C-reactive protein concentrations.   Results:  An inverted U-shaped association was observed between alcohol consumption and changes in HDL. Compared with never drinkers, past, light, moderate and heavy drinkers, respectively, experienced a 0.012, 0.013, 0.017, and 0.008 mmol/l per year slower decrease rate in HDL (P    Conclusions:  Alcohol consumption was associated with slower HDL decreases, with moderate consumption slowest. However, the data suggested differential effects on the basis of alcoholic beverage type.
Abstract 20155: The Adverse Effect of End Stage Renal Disease on Intimal Hyperplasia of Internal Thoracic Artery
Authors: Hirofumi Sato, Yuko Ohashi, Chikara Ueki, Takehide Akimoto, Genichi Sakaguchi
Journal: Circulation (2015)

Introduction: Internal thoracic arteries (ITA) are widely used as a reliable conduit in coronary artery bypass grafting surgery (CABG) because they are said to be less affected by arterioscrelosis. Little is known about the relationships between patient’s characteristics and intimal hyperplasia of ITAs. Hypothesis: The condition of intima of ITA of patients with end stage renal disease (ESRD) is worse than those of patients without ESRD. Methods: The specimens of LITAs and RITAs, obtained from 48 patients who underwent CABG or OPCAB (off-pump CABG) , were evaluated with histopathology; 56 arteries were suitable for morphometric analysis. The severity of disease was evaluated on the basis of percentage of luminal narrowing (%LN) , intimal thickness index (ITI), and intima-to-media ratio (IMR). Results: The patients included 36 males, 15 ESRD, 11 HD patients, 8 peripheral arterial disease (PAD) patients, and their average age was 69.3, average estimated glomerular filtration rate (eGFR) was 49.0 ml/min/1.73m 2 . The %LN was 6.26, ITI was 0.24, and IMR was 0.96 in average. In Spearman's rank correlation test, eGFR was associated with %LN (correlation coefficient -0.242, p=0.07). The %LN of patients with ESRD was significantly higher than that of patients without ESRD ( 7.99 vs 5.48, p=0.001). Conclusions: The lumen of ITAs of patients with ESRD was significantly narrower than that of patients without ESRD.
So you want to understand subsequent injuries better? Start by understanding the minimum data collection and reporting requirements
Authors: Caroline F Finch, Lauren V Fortington
Journal: British Journal of Sports Medicine (2017)

In recent years, there has been increasing recognition of the importance of adequately describing multiple and subsequent injuries in sports injury datasets.1 2 Such information is needed to answer questions such as:

Sports medicine professionals will often consider these questions when athletes present with certain injury profiles. When diagnosing injuries and determining suitable rehabilitation and recovery programmes, sports medicine professionals need to make links between the past, the present and the expected future injury outcomes. Suspecting links and decision making in relation to them should be evidence informed. Epidemiologists also ask similar questions at a broader level across populations or groups of athletes. Epidemiological answers to the above questions can provide important evidence to inform and underpin clinical decision making, but only when based on relevant and robust data. This editorial proposes a …
Notice of Retraction
Journal: Circulation Research (2015)

A recent internal sub-analysis by Baker IDI Heart and Diabetes Institute ("the Institute") of the data presented in this article revealed anomalies that triggered an investigation, which resulted in an admission of fabricated results by Dr Anna Ahimastos.Dr Ahimastos is both the first and corresponding author of this article, and was responsible for data collection and integrity.According to the Institute's finding, no other co-authors were involved in this misrepresentation.In addition, no data from the Townsville and Brisbane recruitment centers were included in this publication, and data from those centers remains valid.All authors recognize the seriousness of this
PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
Authors: Audrey S. Dickey, Dafne N. Sanchez, Martin Arreola, Kunal R. Sampat, Weiwei Fan, Nicolas Arbez, Sergey Akimov, Michael J. Van Kanegan, Kohta Ohnishi, Stephen K. Gilmore-Hall, April L. Flores, Janice M. Nguyen, Nicole Lomas, Cynthia L. Hsu, Donald C. Lo, Christopher A. Ross, Eliezer Masliah, Ronald M. Evans, Albert R. La Spada
Journal: Science Translational Medicine (2017)

PPARδ activation by bexarotene in a mouse model of Huntington’s disease rescues defective oxidative metabolism and is neuroprotective.
Caracterización del seguimiento endoscópico tras resección de cáncer colorrectal de aparición precoz
Authors: J Arribas Anta, A Cañete Ruiz, S Tapial, D Rueda, C Sánchez, L Brandariz, JC Marín Gabriel, G Castellano Tortajada, JB Díaz Tasende, J Perea García
Journal: Endoscopy (2017)

Existen datos para considerar el cáncer colorrectal en jóvenes (CCRJ) (aparición < 45 años) un subgrupo con características propias, sin encontrarse todos los pacientes en el espectro Lynch.
Patient self‐care of periodontal pocket infections
Authors: Nicole Birgit Arweiler, Thorsten M. Auschill, Anton Sculean
Journal: Periodontology 2000 (2017)

Abstract Treatment of periodontitis aims to control the infection caused by the periodontal pathogenic flora and includes mechanical debridement of root surfaces to disrupt the supragingival and subgingival biofilm. As periodontal pockets of ≤ 5 mm can be perform in a stable condition and may not need additional therapy, the ability and the willingness of the patient to perform good oral hygiene on a long‐term basis are of utmost importance for ensuring long‐term success of periodontal treatment. In this context, the aim of all home‐care measures must be the optimal control of plaque biofilm in order to prevent or treat gingival inflammation as a primary stage of periodontitis. Despite the fact that toothbrushing and other mechanical cleaning practices are the most important elements for preventing periodontal diseases or their progression, other factors, including education, motivation, manual dexterity and compliance with professional recommendation, provision of time and socio‐economic status, as well as risk factors, play a role. The present article provides an overview on the various possibilities for self‐care of residual pockets in patients with periodontitis.
Causes of Death after a Hospitalization with AKI
Authors: Samuel A. Silver, Ziv Harel, Eric McArthur, Danielle M. Nash, Rey Acedillo, Abhijat Kitchlu, Amit X. Garg, Glenn M. Chertow, Chaim M. Bell, Ron Wald
Journal: Journal of the American Society of Nephrology (2017)

Mortality after AKI is high, but the causes of death are not well described. To better understand causes of death in patients after a hospitalization with AKI and to determine patient and hospital factors associated with mortality, we conducted a population-based study of residents in Ontario, Canada, who survived a hospitalization with AKI from 2003 to 2013. Using linked administrative databases, we categorized cause of death in the year after hospital discharge as cardiovascular, cancer, infection-related, or other. We calculated standardized mortality ratios to compare the causes of death in survivors of AKI with those in the general adult population and used Cox proportional hazards modeling to estimate determinants of death. Of the 156,690 patients included, 43,422 (28%) died in the subsequent year. The most common causes of death were cardiovascular disease (28%) and cancer (28%), with respective standardized mortality ratios nearly six-fold (5.81; 95% confidence interval [95% CI], 5.70 to 5.92) and eight-fold (7.87; 95% CI, 7.72 to 8.02) higher than those in the general population. The highest standardized mortality ratios were for bladder cancer (18.24; 95% CI, 17.10 to 19.41), gynecologic cancer (16.83; 95% CI, 15.63 to 18.07), and leukemia (14.99; 95% CI, 14.16 to 15.85). Along with older age and nursing home residence, cancer and chemotherapy strongly associated with 1-year mortality. In conclusion, cancer-related death was as common as cardiovascular death in these patients; moreover, cancer-related deaths occurred at substantially higher rates than in the general population. Strategies are needed to care for and counsel patients with cancer who experience AKI.
The Heterogeneous Fusion Gene Landscape in Pediatric Acute Lymphoblastic Leukemia
Authors: Yanara Marincevic-Zuniga, Johan Dahlberg, Sara Nilsson, Amanda Raine, Jonas Abrahamsson, Lucia Cavelier, Erik Forestier, Mats Heyman, Gudmar Lönnerholm, Jessica Nordlund, Ann-Christine Syvänen
Journal: Blood (2016)
Abstract 12990: Genome-wide Associations of Global Electrical Heterogeneity ECG Phenotype: The Atherosclerosis Risk in Communities (ARIC) and Cardiovascular Health (CHS) Studies
Authors: Larisa G Tereshchenko, Nona Sotoodehnia, Colleen M Sitlani, Jonathan W Waks, Muammar Kabir, Mary L Biggs, Tor Biering-Sørensen, Charles A Henrikson, Elsayed Z Soliman, Scott D Solomon, Wendy S Post, Alfred E Buxton, David S Siscovick, Mark E Josephson, Dan E Arking
Journal: Circulation (2016)

Introduction: Abnormal myocardial electrophysiological substrate quantified by global electrical heterogeneity (GEH) is independently associated with sudden cardiac death in the general population. The genetic basis of GEH has not been previously studied. Hypothesis: We hypothesized that a genome-wide association study (GWAS) would identify genetic loci related to GEH. Methods: We tested 22-26 million genotyped and imputed variants in African American (AA, N=3,378) and European American (EA, N=12,802) participants in the Atherosclerosis Risk in Communities and Cardiovascular Health Study cohorts. Five ECG markers of GEH (sum absolute QRST integral (SAI), spatial QRST angle (QRSTA), and spatial ventricular gradient (SVG) magnitude (SVGmag), elevation (SVGel), and azimuth (SVGaz)) were measured on standard 12-lead ECGs. Adjusted linear regression models were constructed with each GEH parameter as an outcome. Results: Ten significant susceptibility loci with 17 SNPs were identified. Multiple GEH parameters were associated with identical SNPs. A low frequency polymorphism (minor allele frequency 0.02) of SCN5A (rs7638275) was strongly associated with SAI (βGWAS -0.30; P=8.71x10 -11 in EA; P=3.49x10 -11 in combined EA/AA). QRSTA, SVGmag, SVGel, and SVGaz were associated with 9 loci, including transcriptional factors ( TBX3, HAND1, NFIA ), implicated in fetal gene program, facilitating molecular remodeling in response to stress. Our strongest association (rs7301677), associated with QRSTA (β GWAS 0.16; P=1.46x10 -26 in the combined EA/AA), was previously reported associated with QRS duration and PR interval, and mapped near the TBX3 gene, which plays a critical role in cardiac conduction system development. Both SAI (P=2.21x10 -10 ) and SVGmag (P=2.40x10 -09 ) were associated with rs7029396 (β GWAS 0.09 in combined EA/AA), mapped near the NCS1 gene, which plays a role in CaMKII-dependent cardiac hypertrophy. SAI was associated with 5 loci; genes in these loci included transcription factors ACTB, SPI-1, IGF1R, GINS3 , and LUZP1 , implicated in cardiac hypertrophy. Conclusions: We identified 10 genetic loci associated with ECG manifestation of GEH. There is a strong association between GEH and genetic signals for molecular remodeling.
Incidencia de los marcadores virales y evaluación del riesgo estimado en la población de donantes de sangre en Suiza de 1996 a 2003
Authors: C Niederhauser, P Schneider, M Fopp, A Ruefer, G Lévy
Journal: Eurosurveillance (2005)

Entre los riesgos conocidos asociados a las transfusiones sanguineas, la transmision de virus patogenos se considera como uno de los mas graves, implementandose con exito durante las ultimas dos decadas una serie de medidas para reducirlo. Actualmente, se considera que el riesgo de transmision de infecciones virales por hemoderivados es muy bajo en los paises desarrollados. 
El siguiente estudio analiza, entre 1996 y 2003, la incidencia del VIH, del virus de la hepatitis B (VHB), y del virus de la hepatitis C (VHC) en el 99% de los donantes de sangre voluntarios de los servicios de transfusion sanguinea de la Cruz Roja Suiza. Tambien se estimo el riesgo de estos marcadores virales. Durante este periodo, la tasa de incidencia del VHC siguio bajando, mientras la incidencia del VIH y del VHB no disminuyo de manera significativa. Entre 2001 y 2003, en el ultimo periodo calculado, el riesgo residual se estimaba en 1 por 1.900.000 para el VIH, 1 por 2.200.000 para el VHC, y 1 por 115.000 para el VHB. Estos resultados coinciden con los estudios internacionales, que han demostrado que entre 1996 y 2003 el riesgo residual fue mas alto para el VHB que para el VHC y el VIH.
Precision Dosing of Alemtuzumab: Population Pharmacokinetic Modeling in Pediatric Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Non-Malignant Diseases
Authors: Tsuyoshi Fukuda, Chie Emoto, Rebecca A Marsh, Lisa Neumeier, Alexander A. Vinks, Parinda A Mehta
Journal: Blood (2016)
Evolution of Acidic Mammalian Chitinase Genes (CHIA) Is Related to Body Mass and Insectivory in Primates
Authors: Mareike C Janiak, Morgan E Chaney, Anthony J Tosi
Journal: Molecular Biology and Evolution (2017)

Insects are an important food resource for many primates, but the chitinous exoskeletons of arthropods have long been considered to be indigestible by the digestive enzymes of most mammals. However, recently mice and insectivorous bats were found to produce the enzyme acidic mammalian chitinase (AMCase) to digest insect exoskeletons. Here, we report on the gene CHIA and its paralogs, which encode AMCase, in a comparative sample of nonhuman primates. Our results show that early primates likely had three CHIA genes, suggesting that insects were an important component of the ancestral primate diet. With some exceptions, most extant primate species retain only one functional CHIA paralog. The exceptions include two colobine species, in which all CHIA genes have premature stop codons, and several New World monkey species that retain two functional genes. The most insectivorous species in our sample also have the largest number of functional CHIA genes. Tupaia chinensis and Otolemur garnettii retain three functional CHIA paralogs, whereas Tarsius syrichta has a total of five, two of which may be duplications specific to the tarsier lineage. Selection analyses indicate that CHIA genes are under more intense selection in species with higher insect consumption, as well as in smaller-bodied species (<500 g), providing molecular support for Kay's Threshold, a well-established component of primatological theory which proposes that only small primates can be primarily insectivorous. These findings suggest that primates, like mice and insectivorous bats, may use the enzyme AMCase to digest the chitin in insect exoskeletons, providing potentially significant nutritional benefits.
Response to Pioglitazone in Patients With Nonalcoholic Steatohepatitis With vs Without Type 2 Diabetes
Authors: Fernando Bril, Srilaxmi Kalavalapalli, Virginia C. Clark, Romina Lomonaco, Consuelo Soldevila-Pico, I-Chia Liu, Beverly Orsak, Fermin Tio, Kenneth Cusi
Journal: Clinical Gastroenterology and Hepatology (2017)
Clinical and Molecular Characteristics of Therapy-Related Acute Lymphoblastic Leukemia
Authors: Caner Saygin, Ryan D. Cassaday, Natalie Reizine, Ilana Yurkiewicz, Michaela Liedtke, Wendy Stock, Richard A. Larson, Cassandra M. Hirsch, Bartlomiej Przychodzen, Mikkael A. Sekeres, Matt Kalaycio, Hetty E. Carraway, Betty K. Hamilton, Ronald Sobecks, Aaron T. Gerds, Sudipto Mukherjee, Aziz Nazha, Donna M. Abounader, Jaroslaw P. Maciejewski, Anjali S. Advani
Journal: Blood (2017)
Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia
Authors: Balázs Mayer, Krisztián Németh, Miklós Krepuska, Vamsee D. Myneni, Dragan Maric, John F. Tisdale, Matthew M. Hsieh, Naoya Uchida, Heon-Jin Lee, Michael J. Nemeth, Kenn Holmbeck, Constance Tom Noguchi, Heather Rogers, Soumyadeep Dey, Arne Hansen, Jeffrey Hong, Ian Chow, Sharon Key, Ildikó Szalayova, Jerome Pagani, Károly Markó, Ian McClain-Caldwell, Lynn Vitale-Cross, W. Scott Young, Michael J. Brownstein, Éva Mezey
Journal: Science Translational Medicine (2017)

Vasopressin stimulates erythropoiesis.
Prognostic miRNA classifier in early-stage mycosis fungoides: development and validation in a Danish nationwide study
Authors: Lise M. Lindahl, Søren Besenbacher, Anne H. Rittig, Pamela Celis, Andreas Willerslev-Olsen, Lise M. R. Gjerdrum, Thorbjørn Krejsgaard, Claus Johansen, Thomas Litman, Anders Woetmann, Niels Odum, Lars Iversen
Journal: Blood (2017)

Mycosis fungoides (MF) is the most frequent form of cutaneous T-cell lymphoma. The disease often takes an indolent course, but in approximately one-third of the patients, the disease progresses to an aggressive malignancy with a poor prognosis. At the time of diagnosis, it is impossible to predict which patients develop severe disease and are in need of aggressive treatment. Accordingly, we investigated the prognostic potential of microRNAs (miRNAs) at the time of diagnosis in MF. Using a quantitative reverse transcription polymerase chain reaction platform, we analyzed miRNA expression in diagnostic skin biopsies from 154 Danish patients with early-stage MF. The patients were subdivided into a discovery cohort (n = 82) and an independent validation cohort (n = 72). The miRNA classifier was built using a LASSO (least absolute shrinkage and selection operator) Cox regression to predict progression-free survival (PFS). We developed a 3-miRNA classifier, based on miR-106b-5p, miR-148a-3p, and miR-338-3p, which successfully separated patients into high-risk and low-risk groups of disease progression. PFS was significantly different between these groups in both the discovery cohort and the validation cohort. The classifier was stronger than existing clinical prognostic factors and remained a strong independent prognostic tool after stratification and adjustment for these factors. Importantly, patients in the high-risk group had a significantly reduced overall survival. The 3-miRNA classifier is an effective tool to predict disease progression of early-stage MF at the time of diagnosis. The classifier adds significant prognostic value to existing clinical prognostic factors and may facilitate more individualized treatment of these patients.
Impact of real-time metabolomics in liver transplantation: Graft evaluation and donor-recipient matching
Authors: Francois Faitot, Camille Besch, Stephanie Battini, Elisa Ruhland, Mihaela Onea, Pietro Addeo, Marie-Lorraine Woehl-Jaeglé, Bernard Ellero, Philippe Bachellier, Izzie-Jacques Namer
Journal: Journal of Hepatology (2017)