tbuckley/cabot-search huggingface dataset:
P190Protection of vascular wall from oxidative injury with supramolecular conjugate of antioxidant enzymes
Authors: A Maksimenko
Journal: Cardiovascular Research (2018)

occurring phenolic compounds found in a variety of plants and fruits.Their simple molecular structures have demonstrated an array of pharmacological activity including antioxidant and antivascular.Due to Chalcones having an easily modifiable scaffold, they are widely used as parent compounds in drug discovery studies.Endothelial cell proliferation and migration are essential for angiogenic growth, so compounds that possess anti-endothelial activity could be developed further as potential inhibitors of angiogenesis.With this in mind, we report the anti-endothelial activity of two novel analogues (AH1 and AH9) derived from the parent compound 2-chloro-2'5'dihydroxychalcone.Method: Chalcones were synthesised via the Claisen-Schmidt condensation and verified via nuclear magnetic resonance (NMR) and mass spectrometry (MS).Primary Human umbilical vein endothelial cells (HUVECs) were cultured according to manufactures protocol.Cells were seeding into 96-well plates (3500 cells/well) and, 24 hours later, treated either with AH1, AH9 or Sorafenib, a known anti-angiogenic drug for 72hr at a concentration of 10 mM.Effects of the compounds on cell proliferation was assessed by quantifying the colorimetric conversion of 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) to purple formazan product (measured at 560 nm).Data are expressed as mean % inhibition of cell proliferation 6 SEM (n¼4).Anti-migratory activity was assessed via the wound healing assay and the effects of the compounds at 3 mM on the width of the scratch across an 8 hour period were compared to untreated control.Analysis was performed by one-way ANOVA with Tukey-Kramer's multiple comparisons test.Data are expressed as mean % of maximum migration 6 SEM (n¼3).Results: AH1 and AH9 displayed significant anti-proliferative activity with inhibitory values of 94.94 6 1.64% and 79.62 6 4.45% compared to Sorafenib, 69.95 6 4.12%, respectively.Effects on HUVEC migration showed that AH9 limited migration to 16.19 6 14.44% (P<0.05 vs. control).AH1 (47.23 6 6.8%) showed similar anti-migratory activity to Sorafenib (52.68 6 3.32%).Conclusion: This preliminary data suggests that AH9 has potential antiangiogenic properties and could be developed further as a potential antiangiogenic or vascular remodelling agent.Further studies will elucidate the molecular mechanism of AH9 action in cells stimulated with known angiogenic agent, VEGF. P190Protection of vascular wall from oxidative injury with supramolecular conjugate of antioxidant enzymes
Time Out — Charting a Path for Improving Performance Measurement
Authors: Catherine H. MacLean, Eve A. Kerr, Amir Qaseem
Journal: New England Journal of Medicine (2018)

Interview with Dr. Catherine MacLean on physician performance measures and their integration into care delivery. (13:02)Download As performance measures proliferate, an American College of Physicians committee rated the validity of 87 measures that are relevant to ambulatory general internal medicine. The committee found that 37% were valid, 35% were not valid, and 28% were of uncertain validity.
Towards elucidating a universal panel of diagnostic biomarkers for early hepatocellular carcinoma
Authors: U. Abellona, D.P. Mark, O. Oleribe, N. Ladep, H. Reeves, S. Greer, M. Prince, S. Ryder, K. Nash, M. Cramp, M. Thursz, J. Nicholson, E. Holmes, S. Taylor-Robinson, E. Okeke, M. Lemoine
Journal: Journal of Hepatology (2018)
Correction -- Effect of Calcium Supplementation on Bone Loss in Postmenopausal Women
Authors: Ian R. Reid
Journal: New England Journal of Medicine (1993)

To the Editor: In our study describing the effects of calcium supplementation on bone loss in normal postmenopausal women (Feb. 18 issue),1 the bone mineral density of the lumbar spine increased significantly during the first six months in both the placebo and calcium-treated groups. We speculated that this increase was attributable to a change in the software for the bone densitometer between the base-line and six-month visits. Further consultation with the manufacturer confirmed that the new software changed the values for bone mineral density of the lumbar spine. We therefore reanalyzed the earlier scans using the new software. This reanalysis . . .
TCTAP A-112 Aorto-ventricular Angulation Does Not Impact on Device Success in Transcatheter Aortic Valve Replacements with the Lotus Valve System
Authors: Hashrul Rashid, Ameera Amiruddin, Kim Be, Andrew Talman, Abdul Rahman Ihdayhid, Liam McCormick, Arthur Nasis, Ian T. Meredith, Robert Gooley
Journal: Journal of the American College of Cardiology (2018)
Basal core promoter mutations as potential predictors of an enlarged intrahepatic HBV reservoir and enhanced cccDNA transcriptional activity in HBeAg negative chronic hepatitis B infection
Authors: L. Colagrossi, R. Salpini, U.S. Gill, A. Battisti, L. Piermatteo, D.D. Carlo, N. Hansi, F.C. Silberstein, C.F. Perno, P. Kennedy, V. Svicher
Journal: Journal of Hepatology (2018)
All Surgical Readmissions Are Not Created Equal
Authors: Yanik J. Bababekov, Brooks V. Udelsman, David C. Chang
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Abstract 123: Increased Susceptibility of Mitochondria to Permeability Transition Pore Opening in Alcoholic Cardiomyopathy
Authors: Larisa Emelyanova, Ekhson Holmuhamedov, Sean Ryan, Kelsey Kraft, Stacie Edwards, Ulugbek Negmadjanov, Alisher Holmuhamedov, Farhan Rizvi, Gracious R. Ross, Yang Shi, A. Jamil Tajik, Arshad Jahangir
Journal: Circulation Research (2017)

Introduction: Although generations of reactive oxygen species and mitochondrial dysfunction have been implicated in pathogenesis of alcoholic cardiomyopathy (ACM), molecular target(s) responsible for myocardial dysfunction in ACM are not well known. Objective: To determine the impact of chronic alcohol exposure on mitochondrial oxidative phosphorylation system (OXPHOS), permeability transition pore (mPTP) opening, and oxidative stress using a rat model of ACM. Methods: Sprague Dawley male rats (1 mo old) were exposed to alcohol (7.5% ethanol) for 3 months to develop ACM. Activity of OXPHOS was assessed enzymatically and by measuring mitochondrial oxygen consumption rate (OCR). The mPTP opening was determined by monitoring abrupt release of Ca 2+ after exposure of mitochondria to Ca 2+ . Western blot and RT-PCR were used to assess the expression of OXPHOS and mPTP protein components and corresponding genes. Malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) were determined in heart tissue homogenates. Results: There was no significant change in OCR or activity of OXPHOS complexes I-V, despite a decrease in complex V protein and Atp6v1e2 gene expression (-1.7-fold, p&lt;0.01) in Alc rats. Mitochondria from Alc rats were more sensitive to Ca 2+ -induced mPTP opening. This was associated with increase in protein expression level of adenine nucleotide translocase 1/2 and voltage dependent anion channel 1. There was no difference in MDA or 4-HNE levels. Conclusion: Increased sensitivity of mitochondria to mPTP opening during long-term alcohol consumption may compromise cardiac energetic reserves and contractility, leading to ACM development and progression.
Ductular reaction cells display an inflammatory profile and recruit neutrophils in alcoholic hepatitis
Authors: B. Aguilar-Bravo, D. Rodrigo-Torres, M. Coll, L. Revilla, D. Blaya, L. Perea, J. Vallverdú, I. Graupera, E. Pose, L. Dubuquoy, C. Armengol, A.L. Nigro, P. Stärkel, P. Mathurin, J. Caballería, J. Lozano, R. Bataller, P. Ginés, P. Sancho-Bru
Journal: Journal of Hepatology (2018)
Immunotherapy for Glioblastoma: Playing Chess, Not Checkers
Authors: Christopher M. Jackson, Michael Lim
Journal: Clinical Cancer Research (2018)

Patients with glioblastoma (GBM) exhibit a complex state of immune dysfunction involving multiple mechanisms of local, regional, and systemic immunosuppression and tolerance. These pathways are now being identified and their relative contributions explored. Delineating how these pathways are interrelated is paramount to effectively implementing immunotherapy for GBM. Clin Cancer Res; 24(17); 4059-61. ©2018 AACRSee related articles by Woroniecka et al., p. 4175 and Mohme et al., p. 4187.
Prevalence of subclinical histological lesions and tolerance biomarkers in long-term adult liver transplant recipients considered for immunosuppression withdrawal
Authors: A. Sanchez-Fueyo, A. Douiri, M. Elstad, E. Kodela, J. Wall, E.B. Riani, G. Alexander, A. Marshall, M. Navasa, J. Ferguson, K.J. Simpson, A. Pascher, E. Jaeckel, P. Tachtatzis, F. Nevens, S. Masson
Journal: Journal of Hepatology (2018)
Limitations of the National Cancer Data Base to Evaluate Early-Stage Anal Cancer Treatment Outcomes
Authors: Andrew G. Renehan, Rebecca Muirhead, David Sebag-Montefiore
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Neuroscience of Addiction: Relevance to Prevention and Treatment
Authors: Nora D. Volkow, Maureen Boyle
Journal: American Journal of Psychiatry (2018)

Addiction, the most severe form of substance use disorder, is a chronic brain disorder molded by strong biosocial factors that has devastating consequences to individuals and to society. Our understanding of substance use disorder has advanced significantly over the last 3 decades in part due to major progress in genetics and neuroscience research and to the development of new technologies, including tools to interrogate molecular changes in specific neuronal populations in animal models of substance use disorder, as well as brain imaging devices to assess brain function and neurochemistry in humans. These advances have illuminated the neurobiological processes through which biological and sociocultural factors contribute to resilience against or vulnerability for drug use and addiction. The delineation of the neurocircuitry disrupted in addiction, which includes circuits that mediate reward and motivation, executive control, and emotional processing, has given us an understanding of the aberrant behaviors displayed by addicted individuals and has provided new targets for treatment. Most prominent are the disruptions of an individual’s ability to prioritize behaviors that result in long-term benefit over those that provide short-term rewards and the increasing difficulty exerting control over these behaviors even when associated with catastrophic consequences. These advances in our understanding of brain development and of the role of genes and environment on brain structure and function have built a foundation on which to develop more effective tools to prevent and treat substance use disorder.
The beneficial effects of non-selective betabockers in secondary prophylaxis are most pronounced in patients without refractory ascites
Authors: N. Pfisterer, C. Dexheimer, E.-M. Fuchs, T. Bucsics, M. Mandorfer, P. Schwabl, I. Gessl, L. Sandrieser, L. Baumann, F. Riedl, B. Scheiner, T. Pachofszky, W. Dolak, C. Schrutka-Kölbl, A. Ferlitsch, M. Schoniger-Hekele, M. Peck-Radosavljevic, M. Trauner, C. Madl, T. Reiberger
Journal: Journal of Hepatology (2018)
Cost-effectiveness of Nusinersen for Spinal Muscular Atrophy
Authors: Randal Charles Richardson
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
P562Expression profiling of complicated and uncomplicated atherosclerotic plaques of the lower extremities
Authors: A Fedorov, A Razuvaev, B Kox, E Ignatieva, J Roy, L Perisic Matic, U Hedin, A Kostareva
Journal: Cardiovascular Research (2018)

junctions, prior to stretching and enlargement of the endothelial cell, followed by alignment around a larger lumen.Conversely, loss of VE-cadherin and inhibition of actin prevented lumen remodelling.Conclusion: Arterial Flt1 by titrating arterial Vegfa regulates the caliber of arterioles during de novo arteriologenesis involving a unique sequence of collective endothelial cell behaviors and actin remodeling events.Plgf and Vegfb, by shifting the Flt1-Vegfa binding equilibrium toward Vegfa release, promote arteriologenesis.Our model suggests that arterial Flt1 may be used as a local cargo to deliver safe Vegfa dosages in revascularization strategies.
TCTAP A-103 Mechanisms of In-stent Restenosis in Hemodialysis Patients
Authors: Norihito Nakamura, Gaku Nakazawa, Shingo Matsumoto, Tsutomu Murakami, Toshiharu Fujii, Masataka Nakano, Yohei Ohno, Norihiko Shinozaki, Fuminobu Yoshimachi, Yuji Ikari
Journal: Journal of the American College of Cardiology (2018)
Hepatocellular Carcinoma‐Associated Protein TD26 Interacts and Enhances Sterol Regulatory Element‐Binding Protein 1 Activity to Promote Tumor Cell Proliferation and Growth
Authors: Chenchen Wang, Ying Tong, Yankai Wen, Jie Cai, Han Guo, Lifeng Huang, Min Xu, Mingxuan Feng, Xiaosong Chen, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia
Journal: Hepatology (2018)

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Increased lipogenesis has been reported to play a critical role in HCC progression. However, the underlying mechanism contributing to lipogenesis increase in HCC remains elusive. Here, we show that HCC-associated protein TD26 (TD26) was highly expressed in HCC tumor tissues compared to matched normal tissues. From the clinicopathologic analyses of two independent HCC cohorts, we demonstrate that TD26 expression was positively correlated with tumor size and was an independent predictor of overall survival (OS) and recurrence-free survival (RFS) in HCC patients. Our metabolomics assays demonstrate that TD26 had no effect on glycometabolism, but significantly increased lipogenesis in HCC cells. In addition, our functional assays indicate that TD26 promoted HCC cell proliferation and tumor growth. We further demonstrate that TD26-mediated increase in lipogenesis and tumor cell proliferation was SREBP1 dependent. Mechanistically, we demonstrate that, through its C-terminus (amino acids [aa] from 121 to 198), TD26 interacted with the truncated nuclear sterol regulatory element-binding protein 1 (SREBP1) form (nSREBP1), but not full-length SREBP1 (flSREBP1), to block adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)-mediated inhibition on SREBP1 activity, resulting in increased lipogenesis, elevated tumor cell proliferation, and enhanced tumor progression. Conclusion: We propose that TD26 is a positive regulator on SREBP1 transactivity, and the interaction between TD26 and SREBP1 can serve as a potential therapeutic target for HCC treatment.
Younger age is associated with lower transplant-free survival relative to a general population in patients with Primary Biliary Cholangitis
Authors: C.F.M. Perez, W.J. Lammers, H. Van Buuren, A. Gulamhusein, A. Cheung, C. Ponsioen, M. Carbone, A.L. Mason, C. Corpechot, M.J. Mayo, P. Invernizzi, P.M. Battezzati, A. Floreani, A. Pares, F. Nevens, K.V. Kowdley, T. Bruns, G. Dalekos, K. Zachou, D. Thorburn, N. Larusso, R. Poupon, P. Trivedi, V. Xavier, H. Janssen, G. Hirschfield, K. Lindor, B. Hansen
Journal: Journal of Hepatology (2018)
Hepatic Hemangioma on SPECT Myocardial Perfusion Imaging
Authors: Susan Taylor, Tricia Francisco, Janet A. Munroe, Hadyn T. Williams
Journal: Clinical Nuclear Medicine (2018)

Abstract Extracardiac uptake on SPECT MPI, seen with physiologic radiotracer distribution, benign or malignant neoplasm, infection, inflammation, or granulomatous disease, may confound the accuracy of MPI or lead to unsuspected pathology. A 38-year-old woman with end-stage renal disease on hemodialysis had SPECT MPI for renal transplant preoperative risk stratification, showing left anterior descending artery ischemia and an intense extracardiac soft tissue focus adjacent to the diaphragmatic right ventricle concerning for focal infection related to prior coronary or gastric surgeries or tumor. CT revealed focal herniation of liver containing a flash-fill hemangioma into the left hemithorax accounting for this focal uptake.
Impact of SVR to IFN-free DAA therapy on steatosis in HIV/HCV coinfected patients
Authors: D. Chromy, P. Schwabl, T. Bucsics, B. Scheiner, C. Schmidbauer, M. Aichelburg, P. Ferenci, M. Trauner, T. Reiberger, M. Mandorfer
Journal: Journal of Hepatology (2018)
Prenatal Organophosphate Pesticide Exposure and Traits Related to Autism Spectrum Disorders in a Population Living in Proximity to Agriculture
Authors: Sharon K. Sagiv, Maria H. Harris, Robert B. Gunier, Katherine R. Kogut, Kim G. Harley, Julianna Deardorff, Asa Bradman, Nina Holland, Brenda Eskenazi
Journal: Environmental Health Perspectives (2018)

Background: Prenatal exposure to organophosphate (OP) pesticides has been linked with poorer neurodevelopment and behaviors related to autism spectrum disorders (ASD) in previous studies, including in the Center for Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a birth cohort living in the agricultural Salinas Valley in California. Objectives: To investigate the association of prenatal exposure to OP pesticides with traits related to ASD, in childhood and adolescents in CHAMACOS. Methods: We assessed OP exposure during pregnancy with measurements of dialkyl phosphates (DAP) metabolites in urine, and residential proximity to OP use during pregnancy using California's Pesticide Use Reporting (PUR) data and estimated associations with ASD-related traits using linear regression models. We measured traits reported by parents and teachers as well as the child's performance on tests that evaluate the ability to use facial expressions to recognize the mental state of others at 7, 10½, and 14 years of age. Results: Prenatal DAPs were associated with poorer parent and teacher reported social behavior [e.g., a 10-fold DAP increase was associated with a 2.7-point increase (95% confidence interval (CI): 0.9, 4.5) in parent-reported Social Responsiveness Scale, Version 2, T-scores at age 14]. We did not find clear evidence of associations between residential proximity to OP use during pregnancy and ASD-related traits. Conclusions: These findings contribute mixed evidence linking OP pesticide exposures with traits related to developmental disorders like ASD. Subtle pesticide-related effects on ASD-related traits among a population with ubiquitous exposure could result in a rise in cases of clinically diagnosed disorders like ASD. https://doi.org/10.1289/EHP2580
Should foot orthoses be used for plantar heel pain?
Authors: Glen A Whittaker, Shannon E Munteanu, Hylton B Menz, Karl B Landorf
Journal: British Journal of Sports Medicine (2018)

The authors of this systematic review1 found that foot orthoses are not effective for plantar heel pain (when compared with sham devices) and suggest ‘that clinicians should be reserved in prescribing foot orthoses in all patients with plantar heel pain’. This finding is in contrast to a similar systematic review and meta-analysis that we recently published in the  British Journal of Sports Medicine  that concluded foot orthoses are effective at reducing pain in those with plantar heel pain and that ‘health practitioners may consider using foot orthoses … but the reduction in pain may not be sufficient for some people’.2

The publication of these meta-analyses in the same journal, within a short time-period may create uncertainty for health practitioners regarding the effectiveness of foot orthoses for plantar heel pain. Furthermore, there may be a loss of trust by health practitioners and members of the public in the process of conducting and reporting systematic reviews and meta-analyses, as reviews by different authors can arrive at contrasting findings. Therefore, it is important to provide context to the different conclusions reached in these meta-analyses in …
<i>Notes from the Field:</i> Increase in Hepatitis A Virus Infections — Marshall Islands, 2016–2017
Authors: Megan G. Hofmeister, Jill A. McCready, Ruth Link-Gelles, Blanche Greene Cramer, Leisha D. Nolen, Helentina Garstang, Monique A. Foster
Journal: MMWR Morbidity and Mortality Weekly Report (2018)
Increased intestinal permeability and inflammation are associated with hepatocellular carcinoma in patients with NAFLD-related liver cirrhosis
Authors: F. Ponziani, S. Bhoori, V. Petito, F.P. Sterbini, D. Morelli, T.D. Michele, M. Sanguinetti, A. Gasbarrini, V. Mazzaferro, M. Pompili
Journal: Journal of Hepatology (2018)