Implantable Cardioverter-Defibrillators for Primary Prevention in Patients With Ischemic or Nonischemic Cardiomyopathy
Authors: Michalina Kolodziejczak, Felicita Andreotti, Eliano Pio Navarese
Journal: Annals of Internal Medicine (2018)

Letters6 February 2018Implantable Cardioverter-Defibrillators for Primary Prevention in Patients With Ischemic or Nonischemic CardiomyopathyMichalina Kołodziejczak, MD, Felicita Andreotti, MD, PhD, and Eliano Pio Navarese, MD, PhDMichalina Kołodziejczak, MDCollegium Medicum in Bydgoszcz, University of Nicolaus Copernicus, Toruń, Poland (M.K.), Felicita Andreotti, MD, PhDCatholic University, Rome, Italy (F.A.), and Eliano Pio Navarese, MD, PhDInova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Fairfax, Virginia (E.P.N.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0692 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Littmann's and Dr. Shah's comments spark a discussion around the therapeutic changes that have taken place over the past 20 years for systolic heart failure and the ensuing treatment differences across the randomized controlled trials included in our analysis of prophylactic ICDs. Although management has indeed changed with recent optimized strategies, the groups of each trial were matched for baseline pharmacologic and resynchronization interventions; therefore, within each randomized controlled trial, all outcomes are balanced between groups, and hazard ratios—used as a summary statistic—are not affected in favor of any randomized group. Because of differences in baseline interventions, ...References1. Køber L, Thune JJ, Nielsen JC, Haarbo J, Videbæk L, Korup E, et al; DANISH Investigators. Defibrillator implantation in patients with nonischemic systolic heart failure. N Engl J Med. 2016;375:1221-30. [PMID: 27571011] doi:10.1056/NEJMoa1608029 CrossrefMedlineGoogle Scholar2. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, et al; Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225-37. [PMID: 15659722] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Collegium Medicum in Bydgoszcz, University of Nicolaus Copernicus, Toruń, Poland (M.K.)Catholic University, Rome, Italy (F.A.)Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Fairfax, Virginia (E.P.N.)Note: All authors are members of the Systematic Investigation and Research on Interventions and Outcomes (SIRIO) MEDICINE Research Network.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-0120. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImplantable Cardioverter-Defibrillators for Primary Prevention in Patients With Ischemic or Nonischemic Cardiomyopathy Michalina Kołodziejczak , Felicita Andreotti , Mariusz Kowalewski , Antonino Buffon , Marco Matteo Ciccone , Gianfranco Parati , Pietro Scicchitano , Julia M. Umińska , Stefano De Servi , Kevin P. Bliden , Jacek Kubica , Alessandro Bortone , Filippo Crea , Paul Gurbel , and Eliano P. Navarese Implantable Cardioverter-Defibrillators for Primary Prevention in Patients With Ischemic or Nonischemic Cardiomyopathy Laszlo Littmann Implantable Cardioverter-Defibrillators for Primary Prevention in Patients With Ischemic or Nonischemic Cardiomyopathy Rahman Shah Metrics Cited byAnalysis of mortality risk following receipt of implantable cardioverter defibrillators in patients with and without heart failureEfficacy of Pharmacologic and Cardiac Implantable Electronic Device Therapies in Patients With Heart Failure and Reduced Ejection Fraction 6 February 2018Volume 168, Issue 3Page: 234-235KeywordsCardiomyopathiesDisclosureForecastingHazard ratioHeart failureImplantable cardioverter defibrillators ePublished: 6 February 2018 Issue Published: 6 February 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...