tbuckley/cabot-search huggingface dataset:
3D-printed scaffolds with synergistic effect of hollow-pipe structure and bioactive ions for vascularized bone regeneration
Authors: Wenjie Zhang, Chun Feng, Guangzheng Yang, Guanglong Li, Xun Ding, Shaoyi Wang, Yuandong Dou, Zhiyuan Zhang, Jiang Chang, Chengtie Wu, Xinquan Jiang
Journal: Biomaterials (2017)
Androgen Deprivation Therapy and Subsequent Dementia
Authors: Jae Heon Kim, Benjamin I. Chung
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Incidence, Severity, Day 100 Treatment Efficacy and Therapy Toxicity of Cytomegalovirus (CMV) Infections with Early Pre-Emptive Therapy in Adult Cord Blood (CB) Transplant Recipients
Authors: Carmen Lau, Valkal Bhatt, Parastoo B. Dahi, Sean Devlin, Yeon Yoo, Nelly G. Adel, Chris Mazis, Miguel Perales, Sergio A. Giralt, Guenther Koehne, Doris M Ponce, Genovefa A Papanicolaou, Juliet N. Barker
Journal: Blood (2016)
Therapeutic drug monitoring to prevent acquired drug resistance of fluoroquinolones in the treatment of tuberculosis
Authors: Lina Davies Forsman, Judith Bruchfeld, Jan-Willem C. Alffenaar
Journal: European Respiratory Journal (2017)

The new short-course World Health Organization (WHO)-endorsed regimen for multidrug-resistant (MDR) tuberculosis (TB) resistant to rifampicin and isoniazid gives hope for patients and care-givers. However, there is still an unacceptable proportion of treatment failure and evidence of man-made acquired drug resistance of fluoroquinolones during programmatic treatment of MDR-TB [1]. The appropriate use of fluoroquinolones is crucial in MDR-TB treatment, perhaps even more so in the new WHO-endorsed short-course MDR-TB regimen. Current shortcomings with inappropriate use of fluoroquinolones, such as underdosing, need to be avoided in order to prevent failure of the new short-course regimen. Therapeutic drug monitoring of fluoroquinolones might prevent acquired XDR-TB <http://ow.ly/jj6b309QXyZ>
The efficacy and efficiency of half frozen section assessment of breast cancer sentinel lymph nodes: A retrospective analysis of 1116 cases.
Authors: Houpu Yang, Shu Wang, Jiajia Guo, Yingming Cao
Journal: Journal of Clinical Oncology (2015)

1055 Background: Sentinel lymph node (SLN) biopsy became the standard of care for the staging of clinically negative axillary lymph node in patients with invasive breast cancer. Surgeons often request intra-operative frozen section assessment of SLN to guide treatment decision during the operation. This study was to assess whether this protocol was accurate and efficient. Methods: We retrospectively reviewed pathology records for consecutive breast cancer patients with frozen section of SLNB examined from 2012 to 2014. We defined paraffin section diagnosis as gold standard. Sensitivity, specificity, false negative rate, and false positive rate were calculated. The waiting time for frozen section analysis was record. Results: In total, 1116 cases involved frozen section evaluation of sentinel lymph nodes. The sensitivity, specificity of frozen section was 79.9%, 99.6% respectively. In 49 cases (20.1% of positive patients), the SLN was called negative during the intra-operative evaluation but positive on final examination (false negative). Furthermore, in another 3 patients, malignancy was only detected on frozen but not on paraffin sections (false positive). The waiting time for frozen diagnosis, unnecessary for true negative patients (77.8%), was 51±17 minutes, which is approximately 1.5 times the duration of a secondary axillary dissection (33±15). Only 17.4% patients from intra-operative half frozen section assessment. Conclusions: We do not recommend intra-operative frozen section to guide further axillary surgery, as the protocol of freezing half of SLN is not an accurate or an efficient method, with a relatively high false negative rate and some false positive cases which might make the axillary staging complicated.
Expanding undergraduate medical education in the UK—at whose cost?
Authors: Ahmed Soualhi, Ayiesha Ahmad
Journal: BMJ (2017)

The BMA has criticised the government’s plans for expanding the medical workforce.1 We too read the consultation document with alarm2 and were particularly distressed by point 3.11, which states that new medical students from overseas (outside the European Economic Area) will have to pay their own placement tariff, a fee paid to healthcare providers to cover costs of a clinical placement. This …
포스터발표 : 그랜드볼룸 ; 신체운동이 비알코올성 지방간과 인슐린 저항성에 미치는 영향 (초)
Authors: 최광준, 조용균, 서현일, 성준모, 이수희, 이우진, 양동진, 김홍주, 전우규, 김병익
Journal: Clinical and Molecular Hepatology (2010)
Limitations of Study on Symptom Checkers
Authors: Hamish S. F. Fraser, Susan Clamp, Carol J. Wilson
Journal: JAMA Internal Medicine (2017)

To the Editor In their Research Letter in a recent issue of JAMA Internal Medicine, Semigran et al1 provide some interesting insights on the diagnostic ability of physicians vs "symptom checkers" on clinical vignettes. However, the study has 2 important limitations that were not mentioned.
Transcatheter Aortic Valve Implantation Within Degenerated Aortic Surgical Bioprostheses
Authors: John G. Webb, Michael J. Mack, Jonathon M. White, Danny Dvir, Philipp Blanke, Howard C. Herrmann, Jonathon Leipsic, Susheel K. Kodali, Raj Makkar, D. Craig Miller, Philippe Pibarot, Augusto Pichard, Lowell F. Satler, Lars Svensson, Maria C. Alu, Rakesh M. Suri, Martin B. Leon
Journal: Journal of the American College of Cardiology (2017)
Clinical phenotypes of perinatal depression and time of symptom onset: analysis of data from an international consortium
Authors: Karen T Putnam, Marsha Wilcox, Emma Robertson-Blackmore, Katherine Sharkey, Veerle Bergink, Trine Munk-Olsen, Kristina M Deligiannidis, Jennifer Payne, Margaret Altemus, Jeffrey Newport, Gisele Apter, Emmanuel Devouche, Alexander Viktorin, Patrik Magnusson, Brenda Penninx, Anne Buist, Justin Bilszta, Michael O'Hara, Scott Stuart, Rebecca Brock, Sabine Roza, Henning Tiemeier, Constance Guille, C Neill Epperson, Deborah Kim, Peter Schmidt, Pedro Martinez, Arianna Di Florio, Katherine L Wisner, Zachary Stowe, Ian Jones, Patrick F Sullivan, David Rubinow, Kevin Wildenhaus, Samantha Meltzer-Brody
Journal: The Lancet Psychiatry (2017)
Exocrine Pancreatic Insufficiency in Diabetes Mellitus: Incidence, Pathogenesis, Diagnosis and Treatment
Authors: S.M. Tkach
Journal: GASTROENTEROLOGY (2020)

Статья посвящена проблеме экзокринной панкреатической недостаточности (ЭПН), которая имеется у значительного числа (30–50 %) больных сахарным диабетом (СД) I и II типа и потенциально может влиять на компенсацию СД. Заместительную ферментную терапию следует рассматривать как один из перспективных методов лечения больных СД. Ее желательно проводить в соответствии с клиническими рекомендациями, изложенными в последних консенсусах, однако более высокими дозами современных ферментных препаратов IV поколения, таких как Пангрол®25000. Дополнительными методами лечения ЭПН у больных СД являются коррекция нутритивного статуса с помощью соответствующей диеты, а также заместительная витаминотерапия.
Annals Story Slam - The Uncomfortable Role
Authors: Hayley Goldbach
Journal: Annals of Internal Medicine (2017)

Web Exclusives2 May 2017Annals Story Slam - The Uncomfortable RoleFREEHayley Goldbach, MDHayley Goldbach, MDFrom Children's Hospitals of Philadelphia, Philadelphia, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W17-0045 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - The Uncomfortable Role "The Uncomfortable Role," by Dr. Hayley Goldbach (Duration 6:05)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: From Children's Hospitals of Philadelphia, Philadelphia, Pennsylvania.Current Author Address: Hayley Goldbach, MD, Children's Hospital of Philadelphia, Philadelphia, PA; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 May 2017Volume 166, Issue 9Page: SS1KeywordsChildren ePublished: 2 May 2017 Issue Published: 2 May 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.Loading ...
Correlation between CD4 lymphocytes count and the opportunistic infections in treated glioblastoma.
Authors: Marie Josee Begin, Karl Belanger, Marie Florescu
Journal: Journal of Clinical Oncology (2012)

2102 Background: Less than 200 CD4 lymphocytopenia happens frequently with temozolomide treatment of glioblastoma. This immunosuppression is associated with many opportunistic infections and antibiotic prophylaxis is given in some centers to prevent Pneumocystis pneumonia. Methods: We analyzed the association between documented culture-proved infections and CD4 lymphocytes level in 140 patients treated with temozolomide in first-line glioblastoma in Notre-Dame Hospital from 2006 to 2009. Demographic and treatment data were collected and analyzed with Kaplan-Meier survival plots and Log Rank tests. Results: The cohort of infected patients was represented by 31 patients who developed 49 culture-proved infections: 21 urinary origin, 8 pulmonary (1 Pneumocytis and 2 Aspergillosis), 5 brain, 5 bacteremia and 2 other. The infected cohort (n=31) had similar demographs, but also similar outcome compared to our control non infected glioblastoma treated patients cohort (n=109) with a 2 year survival of 40.8% vs 50.2% (p=). The median CD4 lymphocytes level was 260, but clearly infections were associated with less than 200 CD4 lymphocytes. During their infection, 20 patients had a CD4 level less than 200, compared with 11 patients with more than 200 CD4 lymphocytes count. Conclusions: CD4 lymphocytopenia less than 200 is associated with increase in number of documented culture-proven infections in patients treated with temozolomide, but the survival is not altered by the infection.
Quality of life in patients receiving herbal therapy for biochemically recurrent prostate cancer.
Authors: Eric Beam, Dongyun Yang, Linyung Ji, David I. Quinn, Susan G. Groshen, Jacek K. Pinski, Tanya B. Dorff
Journal: Journal of Clinical Oncology (2013)

e16073 Background: Men who experience biochemical recurrence after curative therapy for prostate cancer are often treated with androgen deprivation therapy (ADT), though there is no proven survival benefit in this setting. Side effects of ADT negatively impact quality of life (QOL). There is interest in alternative therapies to control PSA without ADT side effects. In conjunction with clinical testing of prostate health cocktail (PHC), a combination herbal therapy for men with biochemically recurrent prostate cancer, we surveyed QOL in trial subjects who were still receiving PHC (n=11), or had moved on to ADT (n=12) or observation (n=16). Methods: Subjects were surveyed using the Functional Assessment of Cancer Therapy-Prostate (FACT-P) instrument, in which respondents report their level of physical and psychological functioning during the past 7 days. The survey was completed in person, by phone, by mail or via online submission. Results: Of the 40 men (93% of total trial subjects) who responded to the survey, the median age was 66 (range 54-84) and PSA was 2.8 (range 1.1-84). 23% had received radiation as primary treatment, 25% radical prostatectomy, and 52% had received both. One patient was receiving radiation at the time of survey and was excluded. In the Physical Well-Being domain, which assesses energy, feeling ill, nausea, pain and trouble meeting needs, there was a significantly lower score among men receiving ADT (median 25; 95% CI 23.5-26.2) compared to those taking PHC (26.5; CI 24.2-27.8) or being observed (28; 26.4-28) (p =0.006). There was no significant difference among the groups in the other domains, though within the Prostate Cancer-Specific Concerns domain significantly more men indicated they were "not at all" able to have/maintain erections in the ADT group (11/12) compared to PHC (6/11) and observation (5/15) (p=0.009). Conclusions: Decisions about treatment for rising PSA levels after curative-intent therapy must be informed by therapeutic value as well as consideration for QOL. We found that men being treated with ADT have a significantly lower physical function score, and the relatively high QOL for patients on a clinical trial of an herbal supplement was similar to that of patients being observed. Clinical trial information: NCT00669656.
Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation
Authors: Chun Zeng, Francesca Mulas, Yinghui Sui, Tiffany Guan, Nathanael Miller, Yuliang Tan, Fenfen Liu, Wen Jin, Andrea C. Carrano, Mark O. Huising, Orian S. Shirihai, Gene W. Yeo, Maike Sander
Journal: Cell Metabolism (2017)
United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment
Authors: Peter S. Hersh, R. Doyle Stulting, David Muller, Daniel S. Durrie, Rajesh K. Rajpal, Perry S. Binder, Eric D. Donnenfeld, Daniel Durrie, David Hardten, Peter Hersh, Francis Price, David Schanzlin, Walter Stark, R. Doyle Stulting, William Trattler, Steven Trokel
Journal: Ophthalmology (2017)
Abstract 78: Pnmt+ "Primer" Cells Give Rise to Cardiac Myocytes and Neurons in the Mammalian Heart: Development of New Experimental Tools for Cardiac Regenerative Medicine Applications
Authors: Namita M Varudkar, Jixiang Xia, Ibrahim Abukenda, Karl Pfeifer, Steven Ebert
Journal: Circulation Research (2012)

Phenylethanolamine n-methyltransferase (Pnmt) catalyzes the conversion of norepinephrine to epinephrine, and thus serves as a marker for adrenergic cells. We employed a combination of immunofluorescent histochemical staining and genetic fate-mapping strategies to show that two separate Pnmt+ cell populations contribute to heart development. Intrinsic cardiac adrenergic (ICA) cells originate from the primary heart field, and contribute to pacemaking, conduction, and working (contractile) myocardium. A second population of cardiac Pnmt+ cells is derived from migrating neural crest. These neural crest adrenergic (NCA) cells appear to contribute to cardiac neurons. By adulthood, most of the Pnmt+ cells show a distinctively left-sided orientation in the heart, with nearly 90% of them being found in the left atrium and ventricle. Surprisingly large swaths of ventricular muscle are derived from Pnmt+ primer cells. Since this region of the heart is highly vulnerable to coronary artery disease and often sustains varying degrees of damage following myocardial infarction, we hypothesize that directed stem cell differentiation into Pnmt+ primer cells could serve as a valuable resource for repair and/or regeneration of left ventricular myocardium for heart disease patients. To test this hypothesis, we have generated stable recombinant mouse embryonic stem cell (mESC) lines that express various fluorescent marker proteins under the control of the endogenous Pnmt gene regulatory network. These cells can be rapidly expanded in culture, sorted, and used for transplantation studies in animal models to determine their therapeutic effectiveness. The cells can be induced along cardiogenic or neurogenic pathways in vitro, and the resulting Pnmt+ cells from each population can then be collected and tested in vivo. To achieve this goal, we have knocked-in a nuclear-localized enhanced green fluorescent protein into the Pnmt locus to create Pnmt-nEGFP recombinant mESCs and mice. We show that nEGFP expression is specifically expressed in Pnmt+ cells in vitro and in vivo. This strategy allows us to identify and isolate Pnmt+ cells to evaluate their effectiveness for cardiac regenerative medicine applications. .
Hodgkin Lymphoma Version 1.2017, NCCN Clinical Practice Guidelines in Oncology
Authors: Richard T. Hoppe, Ranjana H. Advani, Weiyun Z. Ai, Richard F. Ambinder, Patricia Aoun, Celeste M. Bello, Cecil M. Benitez, Karl Bernat, Philip J. Bierman, Kristie A. Blum, Robert Chen, Bouthaina Dabaja, Andres Forero, Leo I. Gordon, Francisco J. Hernandez-Ilizaliturri, Ephraim P. Hochberg, Jiayi Huang, Patrick B. Johnston, Mark S. Kaminski, Vaishalee P. Kenkre, Nadia Khan, David G. Maloney, Peter M. Mauch, Monika Metzger, Joseph O. Moore, David Morgan, Craig H. Moskowitz, Carolyn Mulroney, Matthew Poppe, Rachel Rabinovitch, Stuart Seropian, Mitchell Smith, Jane N. Winter, Joachim Yahalom, Jennifer Burns, Ndiya Ogba, Hema Sundar
Journal: Journal of the National Comprehensive Cancer Network (2017)

This portion of the NCCN Guidelines for Hodgkin lymphoma (HL) focuses on the management of classical HL. Current management of classical HL involves initial treatment with chemotherapy or combined modality therapy followed by restaging with PET/CT to assess treatment response using the Deauville criteria (5-point scale). The introduction of less toxic and more effective regimens has significantly advanced HL cure rates. However, long-term follow-up after completion of treatment is essential to determine potential long-term effects.
Impact of High Molecular Risk Mutations on Overall Survival in WHO-Defined Essential Thrombocythemia and Prefibrotic Primary Myelofibrosis
Authors: Heinz Gisslinger, Martin Schalling, Bettina Gisslinger, Roland Jäger, Edith Bogner, Ashot S Harutyunyan, Jelena D Milosevic Feenstra, Nicole C.C. Them, Maria-Theresa Krauth, Leonhard Muellauer, Juergen Thiele, Robert Kralovics
Journal: Blood (2016)
Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation
Authors: Ingrid G Winkler, Valerie Barbier, Micheal Ward, Michael Tallack, Jessica Lowe, Julie Davies, Johanna Erbani, John L Magnani, Jean-Pierre Levesque
Journal: Blood (2016)
Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax
Authors: Mary Ann Anderson, Constantine Tam, Thomas E. Lew, Surender Juneja, Manu Juneja, David Westerman, Meaghan Wall, Stephen Lade, Alexandra Gorelik, David C. S. Huang, John F. Seymour, Andrew W. Roberts
Journal: Blood (2017)
FDG-Avid Keloid on PET/CT Imaging
Authors: Zu-Gui Li
Journal: Clinical Nuclear Medicine (2017)

Keloid is a benign fibroproliferative growths resulting from an overexuberant healing response. A 51-year-old man with a 20-year history of keloid formation presented with a 1-year history of unexplained progressive weakness of both lower limbs. He was clinically suspected of having paraneoplastic neurologic syndrome. FDG PET/CT was performed to exclude underlying malignancy. FDG PET/CT revealed a giant FDG-avid keloid in the anterior chest wall without any other abnormal FDG uptake in the body. We emphasize that a benign FDG-avid keloid should be considered in the differential diagnosis of FDG-avid cutaneous lesions on PET/CT.
Antibody-Targeted HRP Associated with Indole-3-Acetic Acid Induces in Vitro Apoptosis in Hematological Tumors.
Authors: Leandro Felipe Figueiredo Dalmazzo, Barbara Amelia Aparecida Santana-Lemos, Rafael Henriques Jacomo, Aglair Bergamo Garcia, Eduardo Magalhaes Rego, Luiz M Fonseca, Roberto P Falcao
Journal: Blood (2009)
Reducing blood splatter in dermatological surgery
Authors: E.D. Owen, R.J. Motley
Journal: British Journal of Dermatology (2017)

Aguilar-Duran et al (BJD 2017,176, pp275-6) reconfirmed the increased risk of blood splatter specifically associated with the use of bipolar electrosurgery and recommended wearing a mask with a visor when it is used1. Bipolar Electrosurgery is an excellent means of achieving haemostasis and is an important technique in dermatological surgery. Inadvertent blood splatter may be virtually eliminated by the simple expedient of the surgeon placing a cotton gauze swab over the tips of the bipolar forceps prior to activating the current.

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Abstract P141: Gender Differences in the Development of Severe Pulmonary Hypertension and Right Ventricular Dysfunction in Apolipoprotein E--Deficient Mice Are Eliminated with Increasing Age
Authors: Rod Partow-Navid, Soban Umar, Humann Matori, Andrea Iorga, Alan M Fogelman, Mohamad Navab, Mansoureh Eghbali
Journal: Circulation Research (2011)

Apolipoprotein E (ApoE) is a multifunctional protein and its deficiency leads to the development of atherosclerosis in mice. Patients with pulmonary hypertension (PH) have reduced expression of ApoE in lung tissue. ApoE is known to inhibit endothelial and smooth muscle cell proliferation and has anti-inflammatory and anti-platelet aggregation properties. Young ApoE deficient mice have been shown to develop high fat diet-induced PH in a gender specific manner. Estrous cyclicity peaks at 7–8 months and declines by 9 months of age in mice. Here we investigated the effects of monocrotaline (MCT) on young and middle-aged ApoE deficient mice.Middle-Aged (MA) (11–12 month old) male (n=4) and female (n=4) and young (7–8 month old) male (n=5) and female (n=5) ApoE deficient mice were injected with a single intraperitoneal dose of MCT (60 mg/kg). Mice were closely monitored for ∼4 weeks with serial echocardiography for cardiopulmonary hemodynamic assessment. Direct cardiac catheterisation was performed terminally to record peak systolic right ventricular pressure (RVP). RV, LV, IVS and lung tissue was dissected and weighed. Trichrome staining and histochemical analyses were performed. At ∼4 weeks after MCT, MA male and female and young male mice developed severe PH (RVP: MA male=64±5 mmHg, MA female=71±4 mmHg, young male=60±5 mmHg, p=n.s between all the groups) whereas young females developed significantly less severe PH (RVP: 37±5 mmHg, P&lt;0.05 vs. MA male and female, and young male). MA male and female and young male mice developed severe RV dysfunction (RV ejection fraction (RVEF): MA male=31±2%, MA female=28±4%, young male=36±1%, p=n.s between all the groups) whereas young females showed significantly better RV function (RVEF: 43±2%, P&lt;0.05 vs. MA male and female, and young male). MA male and female mice also developed more severe RV hypertrophy (RV/LV+Septum, MA male=0.49, MA female=0.53, young female=0.39). MA male and female mice also manifested increased peripheral pulmonary artery muscularization and pulmonary fibrosis. Interestingly, the gender differences witnessed between young ApoE deficient male and female mice in the development of severe PH and RV dysfunction are abolished as the mice increase in age.