AB1116 Prevalence of poliautoimmunity and family autoimmunity in mexico
Authors: A Arellano-Martinez, V Gonzalez-Diaz, S Cerpa-Cruz, S Gutierrez-Ureña, J Reyes-Rueda, K Garcia-Osuna, GE Martinez-Bonilla
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Autoimmune diseases share pathophysiological mechanisms, genetic factors and certain environmental triggers. Its frequency is reported up to 43% for poliautoimmunity and almost half of these have family autoimmunity, but this is unknown in our population. <h3>Objectives</h3> To identify the prevalence of poliautoimmunity and family autoimmunity in a Rheumatology Service of a third level hospital in Mexico. <h3>Methods</h3> Observational, descriptive, cross-sectional study. Consecutive outpatients who attended the Rheumatology Service of the Hospital Civil de Guadalajara "Fray Antonio Alcalde" during 2 months were applied a questionnaire to obtain demographic data, autoimmunity and risk factors. Descriptive statistical analysis was done. <h3>Results</h3> Of 1,208 patients, 484 (40%) had autoimmunity, of these 58 (12%) had polyautoimmunity and 6 (1%) with Multiple Autoimmune Syndrome (MAS). The most frequent of 35 autoimmune diseases registered were: RA 42%; SLE 17%; AS 6%; SSc 5%; SSj 4%; PsA 3%; JIA 3%; autoimmune hypothyroidism 3%; APS 2%; Dermatomyositis 2% and Psoriasis 1%. In the group with polyautoimmunity SLE was present in 26 (45%) patients, SSj in 13 (22%) and autoimmune thyroid disease in 14 (24%). In the MAS group autoimmune thyroid disease in 5 patients. Patients with polyautoimmunity developed first: SLE (14%) and RA (14%). In the patient with MAS autoimmune thyroid disease in 33%. Of the 58 patients with poliautoimmunity 31 (53%) have familial autoimmunity, of which SLE is the most frequent in (22%), followed by autoimmune thyroid disease (17%) and RA (16%). All 6 MAS patients had familial autoimmunity. Referent to risk factores: 154/484 reported active smoking. Of the 58 patients with poliautoimmunity, only 23 (40%) had or are current smokers. Of the 6 patients with MAS 50% presented this risk factor.158/484 (33%) patients had periodontal disease. In patients with autoimmune disease 54% were overweight (28%) or obese (26%). Of the 58 patients with poliautoimmunity 48% were overweight and 21% obese; of patients with MAS 50% were overweight or obese. Only one patient had ASIA syndrome with GCA diagnosed. <h3>Conclusions</h3> The search of polyautoimmunity is required in all patients with autoimmune disease and convenient to consider that these patients will have a higher frequency for familial autoimmunity. Smoking and periodontal disease are widely known risk factors that are no taken serious by patients. <h3>References</h3> Raza KeGD. Preclinical Inflammatory Rheumatic Diseases. An Overview and Relevant Nomenclature. Rheumatic Diseseas Clinic of North America. 2014;(40). Coelho Aec. Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic slcerosis. Revista Brasileira de Reumatologia. 2016;: p. 314–22. Anaya Jec. The kaleidoscope of autoimmunity: multiple autoimmune syndromes and familial autoimmunity. Expert Review of Clinical Inmunology. 2007;: p. 623–35. <h3>Disclosure of Interest</h3> None declared