tbuckley/cabot-search huggingface dataset:
AB0542 Multiple sclerosis in patients with primary sjÖgren’s syndrome
Authors: E. Kaltsonoudis, E. Pelechas, S. Konitsiotis, P.V. Voulgari, A.A. Drosos
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Imaging and histopathologic studies in patients with primary Sjögren's Syndrome (pSS) have demonstrated white matter lesions which are indistinguishable from those observed in multiple sclerosis (MS). <h3>Objectives</h3> The purpose of this study was to evaluate the frequency of MS in a cohort of patients with pSS. <h3>Methods</h3> One hundred and twenty-one patients with pSS had been evaluated and followed up in the outpatient Rheumatology Clinic at predefined times since 1994. All patients were classified according to the 2016 ACR-EULAR criteria for SS. During follow-up the clinical, laboratory and imaging findings were all recorded. In addition, Magnetic Resonance Imaging and electrophysiological studies as well as spinal fluid analysis were performed when indicated. The diagnosis of MS was based on the 2010 revised McDonald criteria. <h3>Results</h3> Seven patients were diagnosed as having MS. All patients with MS were female. Mean age at the time of MS diagnosis was 65.5±3.6 years, while pSS has been diagnosed at the mean age of 54.4±3.2 years. Mean time of MS development was approximately 10 years after the pSS diagnosis. pSS patients who developed MS had severe sicca symptoms without other extraglandular manifestations and had positive Ro (SSA) antibodies and a positive minor salivary gland biopsy. pSS patients with MS development were treated appropriately in the Neurology department with biological medications with some improvement of the sicca symptoms. <h3>Conclusions</h3> We found that 5.8% of pSS patients as having MS. This percentage of patients clearly indicates the possibility for the coexistence of a second autoimmune disease with similar if not common pathogenetic mechanisms. Thus patients with pSS should be evaluated carefully and screened appropriately for MS when indicated. <h3>Disclosure of Interest</h3> None declared
Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression
Authors: Svetlana S. Sakhnevych, Inna M. Yasinska, Alison M. Bratt, Ouafa Benlaouer, Isabel Gonçalves Silva, Rohanah Hussain, Giuliano Siligardi, Walter Fiedler, Jasmin Wellbrock, Bernhard F. Gibbs, Yuri A. Ushkaryov, Vadim V. Sumbayev
Journal: Cellular and Molecular Immunology (2018)
Clinical Impact of Local Progression in Pancreatic Cancer
Authors: Nicholas Cardillo, Daniel M. Seible, Katherine E. Fero, Andrew R. Bruggeman, Reith R. Sarkar, Alexa Azuara, Daniel R. Simpson, James D. Murphy
Journal: Journal of the National Comprehensive Cancer Network (2018)

Background: The high prevalence of distant metastatic disease among patients with pancreatic cancer often draws attention away from the local pancreatic tumor. This study aimed to define the complications and hospitalizations from local versus distant disease progression among a retrospective cohort of patients with pancreatic cancer. Methods: Records of 298 cases of pancreatic cancer treated at a single institution from 2004 through 2015 were retrospectively reviewed, and cancer-related symptoms and complications requiring hospitalization were recorded. Hospitalizations related to pancreatic cancer were attributed to either local or distant progression. Cumulative incidence analyses were used to estimate the incidence of hospitalization, and multivariable Fine-Gray regression models were used to identify factors predictive of hospitalizations. Results: The 1-year cumulative incidences of hospitalization due to local versus distant disease progression were 31% and 24%, respectively. Among 509 recorded hospitalizations, leading local etiologies included cholangitis (10%), biliary obstruction (7%), local procedure complication (7%), and gastrointestinal bleeding (7%). On multivariable analysis, significant predictors of hospitalization from local progression included unresectable disease (subdistribution hazard ratio [SDHR], 2.42; P<.01), black race (SDHR, 3.34; P<.01), younger age (SDHR, 1.02 per year; P=.01), tumor in the pancreatic head (SDHR, 2.19; P<.01), and larger tumor size (SDHR, 1.13 per centimeter; P=.02). Most patients who died in the hospital from pancreatic cancer (56%) were admitted for complications of local disease progression. Conclusions: Patients with pancreatic cancer experience significant complications of local tumor progression. Although distant metastatic progression represents a hallmark of pancreatic cancer, future research should also focus on improving local therapies.
AB0139 Investigation of prevotella copri from rheumatoid arthritis patients
Authors: Y. Maeda, D. Motooka, T. Nii, Y. Matsumoto, M. Matsushita, Y. Saeki, M. Narazaki, A. Kumanogoh, S. Nakamura, K. Takeda
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> We have previously reported some of the rheumatoid arthritis (RA) patients had <i>Prevotella copri</i> in the intestine. By using germ-free (GF) SKG mice, we also showed that <i>Prevotella</i>–dominated gut microbiota contribute to the development of arthritis<sup>1)</sup>. However, <i>P. copri</i> itself has not been isolated from RA patients and their molecular biology was unknown. <h3>Objectives</h3> Firstly, we planned to evaluate the intestinal microbiota in RA patients before and after the treatment. Second, we isolated <i>P. copri</i> strains from RA patients and healthy controls (HCs) and analysed whether RA patients-derived <i>P. copri</i> expanded in the intestine of GF mice. <h3>Methods</h3> We first examined whether RA patients have altered composition of microbiota. All the patients were diagnosed according to the American College of Rheumatology/<sup>European League Against Rheumatism 2010</sup> classification criteria for RA. We collected faecal samples from 55 RA patients (61.5±9.5 years, mean ages±SD) and 33 HCs (56.2±8.2 years) to investigate the microbiota by 16S rRNA-based deep sequence technique. We also analysed bacterial counts of <i>Prevotella</i> and <i>Bacteroides fragilis</i> by qPCR method. Moreover, we isolated <i>P. copri</i> from faecal contents of RA patients and HCs. GF mice were inoculated with <i>P. copri</i> from RA patients and HCs for further analysis. <h3>Results</h3> We found that 34.5% (19/55) of RA patients and 18.1% (6/33) of healthy controls have relatively high abundance of <i>Prevotella</i> (&gt;4%) in the intestine. These results were compatible with our previous observations. When we focused on the patients who harboured high abundance of <i>Prevotella</i> in the gut, <i>Prevotella/B. fragilis</i> ratio was decreased after the treatment. The mean <i>Prevotella/B. fragilis</i> ratio were changed from 1.28 to 0.75 (p=0.08). Further analyses revealed that RA patients-derived <i>P. copri</i> successfully colonised to GF-mice and induced Th17 cells in the large intestine. <h3>Conclusions</h3> We found that alternation of microbiota composition was observed after the RA treatment. Moreover, we successfully isolated <i>P. copri</i> from RA patients and HCs. RA patients-derived <i>P. copri</i> efficiently expanded in the intestine of GF mice. <h3>Reference</h3> [1] Maeda Y, et al. Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheumatol2016;68(11):2646–2661. <h3>Disclosure of Interest</h3> None declared
Peri-operative therapy for operable gastroesophageal adenocarcinoma: past, present and future
Authors: V. Aggelis, D. Cunningham, F. Lordick, E.C. Smyth
Journal: Annals of Oncology (2018)

Surgery represents the only chance of cure for patients with gastroesophageal adenocarcinoma; however, surgery alone does not cure most patients. Over the past decade, several multimodality adjunctive treatments have improved survival for patients with operable gastroesophageal adenocarcinoma who are undergoing surgical resection; these include peri-operative chemotherapy, neoadjuvant chemoradiotherapy, adjuvant chemotherapy and adjuvant chemoradiotherapy. More recently, the results of several large randomised trials are leading to a shift in the peri-operative treatment of gastroesophageal cancer, away from anthracycline-based and towards taxane-based chemotherapy regimens. Emerging data support an increased focus on patients who are at high risk for poor operative outcomes such as R1 resection, and on patients who are at high risk for relapse following surgery such as those with lymph node metastases (N1+). Future developments may include use of fluorodeoxyglucose-positron emission tomography to inform a switch to non-cross resistant chemotherapy pre-operatively and substitution of alternative treatments for chemotherapy in high risk post-operative node positive patients. Conversely, in molecularly selected subgroups such as microsatellite unstable gastroesophageal cancer, peri-operative or adjuvant chemotherapy may not be helpful, and treatments such as immunotherapy may be considered. In this review, the most up-to-date clinical trials and translational research in the field of operable gastroesophageal cancer are discussed; with a focus on how best to risk stratify patients with operable disease for peri-operative treatment plus surgery, and how novel therapies might be integrated into standard treatments in order to improve survival outcomes in this patient group.
연구논문 : 간경변증을 동반한 만성 C형간염 환자에서 페그인터페론과 리바비린 병합요법의 치료 효과와 안전성
Authors: 정홍렬 ( Hong Ryeol Cheong ), 우현영 ( Hyun Young Woo ), 허정 ( Jeong Heo ), 윤기태 ( Ki Tae Yoon ), 김동욱 ( Dong Uk Kim ), 김광하 ( Gwang Ha Kim ), 강대환 ( Dae Hwan Kang ), 송근암 ( Geun Am Song ), 조몽 ( Mong Cho )
Journal: Clinical and Molecular Hepatology (2010)

목적: 페그인터페론과 리바비린의 병합요법은 만성 C형간염의 효과적 치료이지만 간경변증을 동반한 환자에서는 치료 효과가 떨어지는 것으로 알려져 있다. 이에 저자들은 간경변증을 동반한 만성 C형간염 환자를 대상으로 페그인터페론과 리바비린 병합요법의 효과 및 부작용을 후향적으로 조사하였다. 대상 및 방법: 2004년 1월부터 2007년 1월까지 간경변증을 동반한 만성 C형간염 환자 중 페그인터페론과 리바비린의 병합요법을 받은 65명을 대상으로 바이러스 반응과 부작용을 조사하였다. 페그인터페론 알파-2a는 체중에 관계없이 180μg을(n=32), 페그인터페론 알파-2b는 1.5μg/kg을 주1회 피하주사하였다. 리바비린은 1형 유전자의 경우 75kg 미만에서는 1,000mg, 75kg 이상에서는 1,200mg을 사용하였고 비1형 유전자의 경우 체중에 관계없이 800mg을 투여하였다. 유전자형에 따라 1형 유전자형 만성 C형간염인 경우는 48주간 치료하였으며 비1형 유전자형은 24주간 치료하였다. 치료 효과는 지속바이러스반응률(SVR)로 평가 하였다. 결과: 본 연구에 포함된 65명 환자 중 HCV유전자 1형 환자(50명)에서 EVR은 70.0%(35/50), ETR은 52.0%(26/50)였고 SVR은 24.0%(12/50)였다. HCV 유전자 비1형 환자(15명)에서 ETR은 53.3%(8/15)였으며 SVR은 33.3%(5/15)였다. 비대상 간경변증 환자(10명)에서 SVR은 대상 간경변증 환자(55명)와 비교하여 큰 차이를 보이지 않았다(20.0% vs. 27.3%, P=0.630). 치료 과정에서 간경변증으로 인한 합병증이 10명에서 발생하였고 11명이 치료 와 관련된 부작용으로 치료를 중단하였다. 결론: 간경변증 환자에게서 페그인터페론과 리바비린의 병합요법은 기존의 간염 환자를 대상으로 한 보고와 비교하여 치료 효과가 낮고 심한 부작용으로 중단하는 경우가 흔하였다. 그러나 진행된 간경변증 환자에서 간이식 외에는 다른 효과적인 치료법이없으므로 만일 부작용이 대해 충분히 주의한다면 일부 환자에서는 병합치료를 고려해 볼 수 있을 것이다.
Supporting the Next Generation of Biomedical Researchers
Authors: Ron Daniels, Victor Dzau
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Addressing Cardiovascular Disease Disparities—Are We Getting Closer to the Truth?
Authors: Clyde W. Yancy
Journal: JAMA Cardiology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
THU0708 Disparity in osteoarthritis knee prevalence- a tale of two cities in iran (TEHRAN) and india (PUNE): findings from who ilar copcord population survey (STAGE I)
Authors: A. Jamshidi, T. Kianifard, R. Ghorpade, M. Shayan, M. Mahmoudi, A. Chopra
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Radiographs are a major deterrent in population surveys. COPCORD (community oriented program for control of rheumatic diseases), a low infrastructure low cost model. advocates clinical approach (www.copcord.org). Iran and India completed COPCORD surveys during 2000–2010. Tehran (dominantly Muslim Shia ethnic) is 35° N, 51° E, altitude 3907' and Pune (dominantly Hindu Maratha ethnic) is 18° N,73° E altitude 1817'. Tehran and Pune represent distinct culture and ethnicity but people in both communities sit and squat (ground). Early reports showed an adjusted prevalence of OA knee was 15.3 in Teheran and 3.4 in Pune. <h3>Objectives</h3> To determine and compare the age gender specific prevalence of knee OA in an urban survey in Iran and India <h3>Methods</h3> 8145 population (51% women) in Pune and 10 107 population (53% women) in Tehran were screened (convenience sampling). House to house survey (Phase 1) identified respondents with past(last 3 months) and/or current musculoskeletal (MSK) pain (last 7 days). Trained community volunteers interviewed respondents to map MSK pain and disability (Phase 2). Concurrently, rheumatologists examined cases to make a clinical diagnosis (phase 3). 8.1% in Iran and 16.6% in Pune population were aged 65+years. The age-gender structure in both surveys (phase 1) was similar to the respective national census. Current data pertains to clinically diagnosed symptomatic OA knees (No X-Rays). Crude prevalence (95% confidence intervals) rate is shown. <h3>Results</h3> The prevalence was 15.1 (14.5, 15.9) in Tehran and 5.6 (5.1, 6.1) in Pune (OR=3.15, 95% confidence interval 2.83, 3.52, p&lt;0.001, ANOVA); knee was the commonest affliction amongst OA sites- 93% in Tehran and 87% in Pune (data not shown). The age gender specific prevalence (percent) is shown in the figure 1. The prevalence was exceptionally high in Iran, both men and women, compared to Pune (Men: OR=2.84, <i>P</i>-value&lt;0.001; Women: OR=2.56,<i> P</i>-value&lt;0.001). The odds ratio remained more or less unchanged for each of the age group by gender. Presentation will include probable risk factors (culture) and global comparisons. <h3>Conclusions</h3> Based on a unique community model, urban surveys in Iran and India showed an enormous burden of OA knee. Women suffered more. The burden was strikingly high and unprecedented in Iran. Further research of life styles and risk factors is required to improve understanding of OA in the community. <h3>Reference</h3> [1] Chopra A. The COPCORD world of musculoskeletal pain and arthritis. Rheumatol (Oxford) 2013. <h3>Disclosure of Interest</h3> None declared
AB1403-HPR Investigation of the validity of bety scale in patients with rheumatoid arthritis
Authors: F.B Oflaz, G. Arın, N.B. Karaca, S. Apraş Bilgen, E. Ünal
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The Cognitive Exercise Therapy Approach is a biopsychosocial model for the patients with rheumatic diseases.<sup>1</sup> Cognitive Exercise Therapy Approach Scale (the authors request that the abbreviation stay as "BETY" as the original in Turkish) is a scale that evaluates the biopsychosocial status of the patients with rheumatic diseases. This scale needs validation studies in different rheumatic diseases.<sup>2</sup> <h3>Objectives</h3> The aim of this study is to investigate the validation of the BETY scale in patients with Rheumatoid Arthritis (RA). <h3>Methods</h3> 120 RA patients were included in this study. To determine the functional status of the patient Health Assessment Questionnaire (HAQ) was used. Rheumatoid Arthritis Quality of Life Scale (RAQoL) and 36-Item Short Form Survey (SF-36) were used to measure quality of life. Hospital Anxiety and Depression Scale (HADS) was used to determine anxiety and depression levels. BETY scale was used to in addition to this questionaires for the validation. <h3>Results</h3> 120 RA patients including 13 men and 107 women were participated in the study. The average age of the participating patients was 28,47±11,39 years and the body mass index was 28.4±6,56. There was a very high correlation between the BETY scale and RAQoL (r=0,817, p&lt;0,001). There was high correlation between the BETY scale and subscale of the HADS-Anxiety, HAQ and subscale of the SF-36 Pain (r=0,617, p&lt;0.001; r=0,606, p&lt;0.001; r= −0, 610, p&lt;0.001, respectively). There was moderate correlation between the BETY scale and subscale of the HADS-Depression, subscales of the SF-36 form Physical Functioning, Role Limitations, Role Limitations Due to Emotioal and General Health Perception (r=-0,597, p&lt;0,001; r=-0,576, p&lt;0,001; r=-0,525, p&lt;0,001; r=-0, 598, p&lt;0,001; r=-0, 420, p&lt;0,001, respectively) (Table 1–2). <h3>Conclusions</h3> There were high or moderate correlations between the BETY scale and valid and reliable scales that are developed for these parameters. The BETY scale can be considered as a valid scale in patients with RA. <h3>References</h3> [1] Kisacik P, Unal E, Akman U, Yapali G, Karabulut E, Akdogan A. Investigating the effects of a multidimensional exercise program on symptoms and antiinflammatory status in female patients with ankylosing spondylitis. Complementary therapies in clinical practice. 2016;22:38–43. [2] Ünal E, Arin G, Karaca Nb, Kiraz S, Akdoğan A, Kalyoncu U, et al. Romatizmalı hastalar için bir yaşam kalitesi ölçeğinin geliştirilmesi: madde havuzunun oluşturulması. Journal of Exercise Therapy and Rehabilitation. 2017;4(2):67–75. <h3>Disclosure of Interest</h3> None declared
AB0029 Characteristic patterns of hla presentation and t cell differentiation in adult-onset still’s disease
Authors: H.-A. Kim, J.-Y. Jung, C.-H. Suh, S. Sohn
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The role of T cells in AOSD pathogenesis remains controversial. In autoimmune and auto-inflammatory diseases, such as rheumatoid arthritis (RA) and Behçet's disease, a human leukocyte antigen (HLA)-restricted T cell response to antigen has been shown to affect disease progression, with several HLA alleles strongly associated with disease severity. <h3>Objectives</h3> In this study, we investigated the frequencies of cells presenting HLA-DP, DQ, and DR, as well as differentiated T cell populations including naïve and effector memory T cells in peripheral blood leukocytes (PBLs) of patients with AOSD. Frequencies of the markers were then compared based on clinical outcomes and disease activity, to better understand the role of these cell populations in the pathogenesis of AOSD. <h3>Methods</h3> This study enrolled 14 active AOSD patients, 20 rheumatoid arthritis (RA) patients, and 20 healthy controls (HC). The percentage of surface-stained cells presenting HLA–DP, DQ, and DR alleles, and the proportions of differentiated T cell populations in peripheral blood leukocytes (PBLs) were measured by flow cytometry. <h3>Results</h3> Patients with AOSD exhibited significantly higher percentages of lymphocytes presenting HLA-DP and HLA-DR, and lower percentages of cells presenting HLA-DQ, than patients with RA or HC. The proportions of CD4+, CD4 +CCR7+, CD4 +CD62L-, and CD8 +CD62L- cells in PBLs were decreased in patients with AOSD relative to patients with RA or HCs. In contrast, AOSD patients exhibited increased proportions of CD8 +naïve T cells in whole blood relative to patients with RA or HC. The proportions of CD4 +effector memory T cells, CD8 +naïve T cells, and CD8 +effector memory T cells in whole blood cells and CD4 +effector memory T cell in lymphocytes were significantly associated with systemic score. <h3>Conclusions</h3> While the frequencies of CD4+, CD8+, CCR7+, CD4 +CCR7+, CD4 +CD62L-, and CD8 +CD62L- cells were significantly decreased in patients with AOSD, the frequency of CD8 +naïve T cells was elevated in patients with AOSD, and correlated with systemic score. Additional studies in a larger cohort of patients will be necessary to evaluate the role of these markers in the pathogenesis of AOSD. <h3>Disclosure of Interest</h3> None declared
Red blood cell adhesion to heme‐activated endothelial cells reflects clinical phenotype in sickle cell disease
Authors: Erdem Kucukal, Anton Ilich, Nigel S. Key, Jane A. Little, Umut A. Gurkan
Journal: American Journal of Hematology (2018)

In sickle cell disease (SCD), 'disease severity' associates with increased RBC adhesion to quiescent endothelium, but the impact on activated endothelium is not known. Increased concentrations of free heme result from intravascular hemolysis in SCD. Heme is essential for aerobic metabolism, and plays an important role in numerous biological processes. Excess free heme induces reactive oxygen species generation and endothelial activation, which are associated with cardiovascular disorders including atherosclerosis, hypertension, and thrombosis. Here, we utilized an endothelialized microfluidic platform (Endothelium-on-a-chip) to assess adhesion of sickle hemoglobin-containing red blood cells (HbS RBCs), from adults with homozygous SCD, to heme-activated human endothelial cells (EC) in vitro. Confluent EC monolayers in microchannels were treated with pathophysiologically relevant levels of heme in order to simulate the highly hemolytic intravascular milieu seen in SCD. RBC adhesion to heme-activated ECs varied from subject to subject, and was associated with plasma markers of hemolysis (LDH) and reticulocytosis, thereby linking those RBCs that are most likely to adhere with those that are most likely to hemolyze. These results re-emphasize the critical contribution made by heterogeneous adhesive HbS RBCs to the pathophysiology of SCD. We found that adhesion of HbS RBCs to heme-activated ECs varied amongst individuals in the study population, and associated with biomarkers of hemolysis and inflammation, age, and a recent history of transfusion. Importantly, the microfluidic approach described herein holds promise as a clinically feasible Endothelium-on-a-chip platform with which to study complex heterocellular adhesive interactions in SCD. This article is protected by copyright. All rights reserved.