tbuckley/cabot-search huggingface dataset:
Abstract 11425: Left Ventricular Function and Coronary Artery Disease in Patients With and Without Diabetes. Long-term Follow-up - Revision-dm2 Trial
Authors: Thiago O Hueb, Martino Martinelli Filho, Rosa M Garcia, Gisele L Peixoto, Sergio Siqueira, Mauricio da Silva Rocha, Luiz A Cesar, Whady Hueb, Jose A Ramires, Roberto Kalil Filho
Journal: Circulation (2016)

Introduction: It is assumed that the left ventricular dysfunction due to ischemic cardiomyopathy is a major determinant of poor prognosis of survival when compared to preserved ventricular function. However, it is unknown the role of diabetes in long-term prognosis in this patient group compared to patients without diabetes. Hypothesis: To investigate whether the presence of diabetes affects the prognosis in ventricular function in long-term follow-up. Methods: We prospectively analyzed in a database, outpatients, previously submitted to percutaneous, surgical or clinical treatment. All patients had multivessel disease and LVEF measures. The events considered were overall mortality, nonfatal myocardial infarction, stroke and additional interventions. Results: From January 2009 to January 2010 were selected 918 consecutive patients, followed until May 2015. They were grouped into: G1, 266 diabetic patients with ventricular dysfunction, G2, 213 diabetic without dysfunction, G3, 213 patients without diabetes and without dysfunction and G4, 226 patients without diabetes and with dysfunction. The mortality rate was 21.6%, 6.1%, 4.2% and 10.6% for Groups 1, 2, 3 and 4 respectively. (p &lt;0.001). The incidence of nonfatal myocardial infarction was 5.3%, 0.5%, 7.0% and 2.6% for groups 1, 2, 3 and 4 respectively (p &lt;0.001). Stroke occurred at 0.40% 0.45%, 0.90% and 0.90% in groups 1, 2, 3 and 4 respectively (p = NS). Further interventions occurred in 3.8%, 11.7%, 10.3% and 2.6% for groups 1, 2, 3 and 4 respectively (p &lt;0.001). Conclusion: In this sample, regardless of the treatment received, diabetes mellitus added higher risk of cardiovascular events in patients with coronary artery disease and left ventricular dysfunction.
Os primeiros resultados do novo sistema de vigilância do VIH em França
Authors: F Lot, C Semaille, F Cazein, F Barin, R Pinget, J Pillonel, J C Desenclos
Journal: Eurosurveillance (2004)

Como complemento a vigilância do Sida, os dados sobre as infeccoes pelo VIH sao necessarios para melhor seguir a dinamica da epidemia. Este artigo apresenta os primeiros resultados do sistema de notificacao obligatoria e anonima do VIH, em relacao a vigilância virologica das infeccoes recentes pelo VIH e dos tipos, grupos e sub-tipos de VIH em circulacao. 
As notificacoes obligatorias sao iniciadas pelos microbiologos que cream un codigo anonimo para cada paciente. Os medicos clinicos completam esse formulario de notificacao con as informacoes clinicas e epidemiologicas. Depois, mandam-se as declaracoes as autoridades sanitarias locais que transmettem ao Institut de veille sanitaire (InVS).
Os laboratorios mandam, de forma voluntaria, as amostras de sangue seco ao laboratorio nacional de referencia do VIH. O mesmo realiza um teste de immunidade para detectar as infeccoes recentes (l6 meses) e un serotipado para determinar o grupo e o sub-tipo. Os resultados virologicos sao mandados para o InVS aonde sao ligados com as informacoes da notificacao obligatoria. 
A proporcao de mulheres era de 43%. Globalmente, 53% dos casos notificados eram heterosexuais, dos cuais 47% eram originarios da Africa sub-sahariana. Entre os homens, 36% dos casos declarados eram homosexuais. Uma amostra de sangue seco era disponivel para 64% dos novos diagnosticos de VIH. Em 38,4% dos casos foi identificada uma infeccao recente, com 22,2% em UDVP e 58,1% em homosexuais. Esta taxa era de 26% nos migrantes de origem sub-sahariana. As infeccoes pelo VIH-1 representavam 98% de todas as notificacoes, com 47,8% de sub-tipos nao-B. 
Os primeiros resultados de nosso sistema de notificacao do VIH mostram que a transmissao heterosexual e predominante em Franca, especialmente em pessoas originarias da Africa sub-sahariana. Mais da metade das infeccoes recentes tem sido identificada em homens homosexuais, indicando talvez um aumento da incidencia do VIH nesta populacao.
TCT-837 Clinical Impact of Complete Coronary Artery Revascularization in Elderly Patients with Unprotected Left Main Disease Treated with Drug-Eluting Stent
Authors: Angela Migliorini, Renato Valenti, Ruben Vergara, Eleonora Gabrielli, Maria Grazia De gregorio, Raffaele Martone, Sofia Morini, Maria Raffaella Aicale, Andrea Bernardini, Martina Berteotti, Nazario Carrabba, David Antoniucci
Journal: Journal of the American College of Cardiology (2017)
Inhibition of fatty acid synthase induces reactive oxygen species (ROS) to inhibit HER2 overexpressing breast cancer cell growth
Authors: binghui Li, Ingrid Espinoza, Hong Liu, Ruth Lupu
Journal: Cancer Research (2007)

4462   Recently, FAS inhibition has been frequently reported to induce apoptosis in different cancer cells. Thus, FAS emerges as a potential target for the treatment of cancer. We have determined a bidirectional regulation between FAS and the oncogene HER2. However, the comprehensive role of FAS in cancer cells remains unknown. To assess the impact of FAS in breast cancer cells, we created a specific silencing RNA for FAS and introduced it into a retroviral vector to generate stable cell lines. Three cell lines were used to express the siRNA for FAS and the control vector. The cell lines used are SK-Br3 and BT474 (overexpressing FAS and HER2) and MCF-7 (expressing low levels of both). While expression of FAS was drastically diminished in SK-Br3/FAS-siRNA, BT474/FAS-siRNA and slightly decreased in the MCF-7/FAS-siRNA, the control vector siRNA had no effect on the level of FAS. Likewise, the level of HER2 was significantly reduced in both SK-Br3/FAS-siRNA and BT474/FAS-siRNA cells. No significant reduction in HER2 expression was observed in MCF-7/FAS-siRNA cells. Moreover, a significant decrease in HER2 transcriptional activity was also observed correlated with a decrease in HER2 expression, corroborating our previous observations. Constitutive inhibition of FAS expression promoted a significant inhibition in anchorage-dependent growth compared with the vector and wild type cells. FAS is an important contributor to the redox balance since it oxidizes fourteen moles of NADPH to synthesize one mole of product. To assess the mechanism by which FAS inhibition attenuates breast cancer cell growth, we tested the levels of reactive oxygen species (ROS). A marked increase in ROS level was observed in SK-Br3/FAS-siRNA and BT474/FAS-siRNA cells as compared with their vector control cells measured by flow cytometry, indicating that while FAS expression is attenuated, the cells produce oxidative stress that induces ROS. To test this hypothesis we used NAC (N-acetyl-cysteine, a strong ROS scavenger) to decrease ROS level. Our results demonstrate that ROS indeed is a key modulator for cell growth inhibition by FAS attenuation since NAC rescues cell growth inhibition in FAS-siRNA expressing cells. More interestingly, while NAC does not bring back FAS level, it completely restores HER2 expression in SK-Br3/FAS-siRNA and BT474/FAS-siRNA cells. The results indicate that in this case, the slower growth of the engineered cell lines/FAS-siRNA is not directly due to inhibition of FAS expression; it strongly suggests that resulted increase in ROS production mediates expression of lower HER2 protein and is the key molecular basis for the growth inhibition via blockage of FAS expression. Therefore, our results suggest that FAS is a critical component to maintain the redox balance in breast cancer cells. FAS inhibition perturbs this balance and produces ROS to affect the growth of HER-2 overexpressing cells.
Sticking to principles and anticipating outcomes
Authors: Tom Jefferson
Journal: Journal of the Royal Society of Medicine (2017)

Riassunto La pubblicazione di Unanticipated outcomes, la storia personale di Jerome P. Kassirer, ex direttore del New England Journal of Medicine, offre l'opportunita di considerare i principi etici dell'editoria biomedica e scientifica. Il conflitto di interessi, le dichiarazioni e la frode influenzano la credibilita della comunicazione medica, che poggia sulla robustezza e sulla trasparenza dei suoi processi. Non tutto e ancora perduto, ma dobbiamo essere guidati da forti principi morali e da un quadro coerente di valori.
Le Basic Surveillance Network, une base de données européenne pour la surveillance des maladies infectieuses
Authors: A Ternhag, A Tegnell, B Lesko, K Skaerlund, P Penttinen
Journal: Eurosurveillance (2004)

Le Basic Surveillance Network mis en place en 2000, est l'un des reseaux sur les maladies transmissibles finance par la Commission Europeenne. Y sont recueillies et mises a disposition des donnees de surveillance fondamentales sur les maladies infectieuses de tous les 'anciens' pays membres de l'Union Europeenne (pre-2004). L'objectif est de fournir un acces aise aux donnees descriptives deja disponibles dans les bases de donnees nationales, facilitant ainsi la surveillance et la comparaison des tendances des incidences des maladies infectieuses dans les Etats membres de l'UE. 
La liste de maladies couvertes par le reseau, initialement limitee a 10 maladies pilote, a ete recemment etendue a plus de 40 maladies. Cette liste, etablie par l'UE, comprend toutes les maladies devant faire l'objet d'une surveillance specifique. Les nouveaux Etats membres vont prochainement etre invites a participer a ce reseau. 
Les donnees sont basees sur les cas et comprennent la date d'apparition de la maladie, l'âge et le sexe. Seules quelques tres rares variables complementaires specifiques a certaines maladies sont collectees, telles que le pays d'infection ou le statut immunitaire. La classification en cas (possible, probable et confirme) correspond aux definitions de l'UE. 
Les participants ont acces a un site internet ou toutes les donnees sont presentees sous forme de tableaux et graphiques. De plus, il existe un site accessible au public ( https://www.eubsn.org./BSN/).
VLITL is a major cross-β-sheet signal for fibrinogen Aα-chain frameshift variants
Authors: Cyrille Garnier, Fatma Briki, Brigitte Nedelec, Patrick Le Pogamp, Ahmet Dogan, Nathalie Rioux-Leclercq, Renan Goude, Caroline Beugnet, Laurent Martin, Marc Delpech, Frank Bridoux, Gilles Grateau, Jean Doucet, Philippe Derreumaux, Sophie Valleix
Journal: Blood (2017)
Abstract 15860: Arterial and Cardiac Hemodynamics in Advanced HF Patients Implanted With the C-Pulse Counterpulsation Device: Implications for Myocardial Recovery
Authors: J. Eduardo Rame, Dimitrios Georgakopoulos, David Pomfret, Pavan Atluri, Phi Wiegn, Patrick Segers, William T Abraham
Journal: Circulation (2015)

Introduction: Despite intensive medical and device therapy, many HF patients remain symptomatic with refractory NYHA class III/IV. Therapeutic options are limited in this population, with the goal being stabilization of HF progression. A novel approach is the use of an extra-aortic counterpulsation device, C-Pulse™, consisting of an extra-vascular balloon cuff wrapped around the ascending aorta. The C-Pulse operates on principle of counterpulsation however placement on the proximal aorta may afford unique hemodynamic advantages over traditional counterpulsation devices. We report for the first time hemodynamic effects from advanced HF patients implanted with C-Pulse. Methods: Radial tonometry and office BP were measured in successive patients (N=6) NYHA Class III/IV, 5M, EF 17.2±6.6%, age 67.8±9.7 years (mean±SD), during device optimization. Median time from implant was 180 days (range 1-1356 days). Waveforms and blood pressure were obtained after 5 minute steady state OFF period followed by device optimization (ON). Results: Systolic and diastolic BP were maintained with optimization (Table). Myocardial perfusion indexed by subendocardial viability ratio (SEVR) significantly increased primarily resulting from increase in diastolic area, Ad. Cardiac ejection was enhanced; increased forward wave amplitude, P1, and reduced time to peak pressure, P2. Late systolic load from wave reflections was also reduced assessed by augmentation index (Aix). Conclusions: In this small cohort, C-Pulse increased myocardial perfusion and reduced early and late components of cardiac load. Novel finding of reduced Aix may arise from aortic arch baroreceptor stimulation due to enhanced pulsatility or mechanical deformation from the balloon. These changes may translate into improved heart failure symptoms, cardiac reverse remodeling and possibly recovery.Further studies are needed to assess these mechanisms and their association with regression of heart failure.
c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals
Authors: Christopher D. Nishimura, Daniel A. Brenner, Malini Mukherjee, Rachel A. Hirsch, Leah Ott, Meng-Fen Wu, Hao Liu, Olga Dakhova, Jordan S. Orange, Malcolm K. Brenner, Charles Y. Lin, Caroline Arber
Journal: Blood (2017)
Incidence, clinical management, and mortality risk following self harm among children and adolescents: cohort study in primary care
Authors: Catharine Morgan, Roger T Webb, Matthew J Carr, Evangelos Kontopantelis, Jonathan Green, Carolyn A Chew-Graham, Nav Kapur, Darren M Ashcroft
Journal: BMJ (2017)

Objectives To examine temporal trends in sex and age specific incidence of self harm in children and adolescents, clinical management patterns, and risk of cause specific mortality following an index self harm episode at a young age.Design Population based cohort study.Setting UK Clinical Practice Research Datalink-electronic health records from 647 general practices, with practice level deprivation measured ecologically using the index of multiple deprivation. Patients from eligible English practices were linked to hospital episode statistics (HES) and Office for National Statistics (ONS) mortality records.Participants For the descriptive analytical phases we examined data pertaining to 16 912 patients aged 10-19 who harmed themselves during 2001-14. For analysis of cause specific mortality following self harm, 8638 patients eligible for HES and ONS linkage were matched by age, sex, and general practice with up to 20 unaffected children and adolescents (n=170 274).Main outcome measures In the first phase, temporal trends in sex and age specific annual incidence were examined. In the second phase, clinical management was assessed according to the likelihood of referral to mental health services and psychotropic drug prescribing. In the third phase, relative risks of all cause mortality, unnatural death (including suicide and accidental death), and fatal acute alcohol or drug poisoning were estimated as hazard ratios derived from stratified Cox proportional hazards models for the self harm cohort versus the matched unaffected comparison cohort.Results The annual incidence of self harm was observed to increase in girls (37.4 per 10 000) compared with boys (12.3 per 10 000), and a sharp 68% increase occurred among girls aged 13-16, from 45.9 per 10 000 in 2011 to 77.0 per 10 000 in 2014. Referrals within 12 months of the index self harm episode were 23% less likely for young patients registered at the most socially deprived practices, even though incidences were considerably higher in these localities. Children and adolescents who harmed themselves were approximately nine times more likely to die unnaturally during follow-up, with especially noticeable increases in risks of suicide (deprivation adjusted hazard ratio 17.5, 95% confidence interval 7.6 to 40.5) and fatal acute alcohol or drug poisoning (34.3, 10.2 to 115.7).Conclusions Gaining a better understanding of the mechanisms responsible for the recent apparent increase in the incidence of self harm among early-mid teenage girls, and coordinated initiatives to tackle health inequalities in the provision of services to distressed children and adolescents, represent urgent priorities for multiple public agencies.
Abstract 18669: A Novel Association Between GATA4 and Left Ventricular Noncompaction
Authors: Vi T Tang, Patricia Arscott, Adam S Helms, Sharlene M Day
Journal: Circulation (2016)

Background: Left ventricular noncompaction (LVNC) is characterized by a heavily trabeculated left ventricle and often systolic dysfunction. In contrast to other inherited cardiomyopathies, only in ...
Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection
Authors: Franziska Niehr, Theresa Eder, Tanja Pilz, Robert Konschak, Denise Treue, Frederick Klauschen, Michael Bockmayr, Seval Türkmen, Korinna Jöhrens, Volker Budach, Ingeborg Tinhofer
Journal: Clinical Cancer Research (2017)

Purpose: Platinum-based drugs, in particular cisplatin (cis-diamminedichloridoplatinum(II), CDDP), are used for treatment of squamous cell carcinoma of the head and neck (SCCHN). Despite initial responses, CDDP treatment often results in chemoresistance, leading to therapeutic failure. The role of primary resistance at subclonal level and treatment-induced clonal selection in the development of CDDP resistance remains unknown.Experimental Design: By applying targeted next-generation sequencing, fluorescence in situ hybridization, microarray-based transcriptome, and mass spectrometry-based phosphoproteome analysis to the CDDP-sensitive SCCHN cell line FaDu, a CDDP-resistant subline, and single-cell derived subclones, the molecular basis of CDDP resistance was elucidated. The causal relationship between molecular features and resistant phenotypes was determined by siRNA-based gene silencing. The clinical relevance of molecular findings was validated in patients with SCCHN with recurrence after CDDP-based chemoradiation and the TCGA SCCHN dataset.Results: Evidence of primary resistance at clonal level and clonal selection by long-term CDDP treatment was established in the FaDu model. Resistance was associated with aneuploidy of chromosome 17, increased TP53 copy-numbers and overexpression of the gain-of-function (GOF) mutant variant p53R248L siRNA-mediated knockdown established a causal relationship between mutant p53R248L and CDDP resistance. Resistant clones were also characterized by increased activity of the PI3K-AKT-mTOR pathway. The poor prognostic value of GOF TP53 variants and mTOR pathway upregulation was confirmed in the TCGA SCCHN cohort.Conclusions: Our study demonstrates a link of intratumoral heterogeneity and clonal evolution as important mechanisms of drug resistance in SCCHN and establishes mutant GOF TP53 variants and the PI3K/mTOR pathway as molecular targets for treatment optimization. Clin Cancer Res; 24(1); 158-68. ©2017 AACR.
Are Surgical Residents Prepared to Care for Transgender Patients?
Authors: Shane D. Morrison, Jesse R. Smith, Samuel P. Mandell
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
A risk adjustment approach to estimating the burden of skin disease in the United States
Authors: Henry W. Lim, Scott A.B. Collins, Jack S. Resneck, Jean Bolognia, Julie A. Hodge, Thomas A. Rohrer, Marta J. Van Beek, David J. Margolis, Arthur J. Sober, Martin A. Weinstock, David R. Nerenz, Wendy Smith Begolka, Jose V. Moyano
Journal: Journal of the American Academy of Dermatology (2017)
Infecciones recientes por HTLV diagnosticadas en Inglaterra y Gales, 2002-2004
Authors: S Dougan, Alan Smith, J C Tosswill, K Davison, M Zuckerman, G P Taylor
Journal: Eurosurveillance (2005)

Los HTLV (Human T cell lymphotropic viruses) son retrovirus transmitidos por la leche materna, las relaciones sexuales, las transfusiones sanguineas y el uso de drogas inyectadas. Los HTLV son endemicos en el Caribe y ciertas zonas de Africa, Japon y America del Sur, con focos aislados en otras regiones del mundo. La infeccion es cronica. Menos del 5% de las personas infectadas desarrollan alguna de las enfermedades ligadas al virus, pero estas son debilitantes y frecuentemente mortales. 
En Inglaterra y Gales, las notificaciones microbiologicas y clinicas de los nuevos diagnosticos de HTLV se recogen de forma rutinaria, incluyendo las infecciones identificadas por el departamento de donaciones de sangre desde la introduccion del cribado del HTLV en agosto de 2002.
Entre 2002 y 2004, fueron confirmadas positivas para el HTLV 273 personas, de las cuales 102 (37%) fueron varones y 169 mujeres (el sexo no estaba notificado para dos casos). En el momento del diagnostico, la edad mediana era de 54 anos para los varones y 50 para las mujeres. Se disponia de la historia clinica en el 78% (212/273) de los casos. De los que tenian informacion disponible, el 58% (116/199) eran negros del Caribe y el 29% (57/199) blancos. El 87% (128/147) de los casos fueron probablemente infectados por via sexual o por transmision de madre a hijo; y el origen mas probable de la infeccion fue el Caribe en el 45% de los casos (66/146), y el Reino-Unido en el 40% (59/146). 
Un numero notable de infecciones por HTLV siguen siendo identificadas en Inglaterra y Gales, con un aumento en 2002-2003, debido al cribado anti-HTLV en las donaciones sanguineas. Aunque la mayoria de las infecciones diagnosticadas esten directamente asociadas con el Caribe, la transmision de las infecciones por HTLV se produce en el interior de Inglaterra y Gales. Las unidades de cuidados especializados para las personas infectadas por el HTLV y sus familias mejoraron estos ultimos anos, pero la prevencion sigue siendo limitada.
La trichinellose est toujours un problème en Europe
Authors: J Dupouy-Camet
Journal: Eurosurveillance (2006)

La trichinellose est une maladie zoonotique due a l’ingestion de viande crue contenant des larves du nematode Trichinella. En Europe, il existe quatre especes de trichinelles : Trichinella spiralis (espece cosmopolite), T. britovi (dans la faune sauvage des regions montagneuses), T. nativa (animaux sauvages de regions plus froides et nordiques) et T. pseudospiralis (une espece non encapsulee cosmopolite). Chez l’homme, la trichinellose est responsable de fievre elevee, oedeme facial, myosotis et eosinophilie. Elle peut representer un vrai danger, surtout chez les personnes âgees pour lesquelles des complications neurologiques ou cardiovasculaires peuvent avoir une issue fatale.
Informe resumen de la situación en Amsterdam: aumento de las enfermedades de transmisión sexual y de los comportamientos sexuales de riesgo en hombres homosexuales, relacionados con la introducción de los nuevos tratamientos anti-VIH
Authors: G Stolte, N H T M Dukers, J B F de Wit, H Fennema, R A Coutinho
Journal: Eurosurveillance (2002)

El preocupante aumento de las enfermedades de transmision sexual (ETS) en Amsterdam ha sido analizado en dos estudios realizados por el Departamento de Investigacion del SIDA del Servicio de Salud Municipal. Los resultados indican que la introduccion de Tratamientos Antirretrovirales de Gran Actividad (TARGA) pueden haber influido en el aumento de ETS y de los comportamientos sexuales de riesgo en Amsterdam.