tbuckley/cabot-search huggingface dataset:
Traitement endoscopique des complications des kystes hydatiques du foie rompus dans les voies biliaires: Expérience d'un service marocain
Authors: H Boutallaka, H Seddik, K Loubaris, F Bouhamou, A Aomari, S Morabit, S Jamal, R Berraida, I El Koti, S Sentissi, A Benkirane
Journal: Endoscopy (2018)

Le kyste hydatique du foie (KHF) est une affection parasitaire due au développement de la forme larvaire du tænia du chien Echinococcus granulosus. Par sa latence clinique, le diagnostic est fait le plus souvent au stade de complications. La fistulisation du kyste hydatique dans les voies biliaires en est la complication la plus fréquente. Le traitement endoscopique s'impose en raison des problèmes thérapeutiques et aux risques liés à la chirurgie. L'objectif de notre étude était d'évaluer et d'analyser l'efficacité de la CPRE dans le diagnostic et le traitement des kystes hydatiques du foie rompus dans les voies biliaires.
Gestion des Sténoses Biliaires péri-hilaires Malignes par Voie Endoscopique: Une Expérience Marocaine
Authors: M Acharki, A Sarhani, S Ghani, M Salihoun, N Kabbaj
Journal: Endoscopy (2018)

Le développement de l'endoscopie interventionnelle a produit un bouleversement profond dans le traitement des sténoses des voies biliaires. Nous rapportons notre propre expérience en matière de prise en charge des sténoses biliaires malignes par voie endoscopique.
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS
Authors: Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Yuichiro Semba, Mohammad Shboul, Mohammed Al-Raqad, Manami Maeda, Vivien A.C. Schoonenberg, Mitchel A. Cole, Claudio Macias-Trevino, Yuichi Ishikawa, Qiuming Yao, Michitaka Nakano, Fumio Arai, Stuart H. Orkin, Bruno Reversade, Silvia Buonamici, Luca Pinello, Koichi Akashi, Daniel E. Bauer, Takahiro Maeda
Journal: Cancer Cell (2018)
Surgical Residents and Medical Malpractice—Reply
Authors: Cornelius A. Thiels, Elizabeth B. Habermann, Martin D. Zielinski
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
A Bird's-Eye View of Fever
Authors: John J. Ross, Sophia Koo, Alfred Ian Lee, Stuart B. Mushlin, Danny A. Milner
Journal: New England Journal of Medicine (2011)

A 78-year-old man presented to his primary care physician with a 4-month history of worsening fatigue, generalized weakness, and anorexia, with an unintentional weight loss of 11.4 kg (25 lb). He reported subjective fevers, chills, drenching night sweats, dry mouth, a nonproductive cough, dyspnea with minimal exertion, and nausea with occasional emesis. He became light-headed on standing . . .
Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy
Authors: Krista J. Spiller, Clark R. Restrepo, Tahiyana Khan, Myrna A. Dominique, Terry C. Fang, Rebecca G. Canter, Christopher J. Roberts, Kelly R. Miller, Richard M. Ransohoff, John Q. Trojanowski, Virginia M.-Y. Lee
Journal: Nature Neuroscience (2018)
Traitement endoscopique des diverticules de zenker: étude multicentrique rétrospective francaise sur 125 patients
Authors: F Gaiani, A Charachon, E Coron, A Amiot, J Branche, S Koch, E Chabrun, Y Le Baleur
Journal: Endoscopy (2018)

le diverticule du tiers superieur de l'oesophage dit de «Zenker» est une pathologie rare (1/100 000) et est en rapport avec une hernie de la muqueuse pharyngée a travers la couche musculaire du muscle crico pharyngien. Bien que bénin, il peut causer une symptomatologie severe responsable d'une altération de la qualité de vie des patients qui restreignent leur alimentation et peuvent dans les cas les plus severes etre responsables de pneumopathie d'inhalation. Deux approches sont actuellement disponibles: la chirurgie ouverte par cervicotomie, resection du diverticule et section du crico pharyngien efficace mais morbide en premiere intention soit la section du mur diverticulaire (Par les chirurgiens ORL apres mise en place d'un diverticuloscope rigide ou plus recemment par les gastroentérologues sous controle endoscopique apres mise en place d'un divertucloscope souple).
P115 Low dose radiation has a positive impact on bone metabolism in an experimental model of inflammatory arthritis
Authors: L Deloch, M Rückert, AJ Hueber, M Herrmann, R Fietkau, B Frey, US Gaipl
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Introduction</h3> Rheumatoid arthritis (RA) is, next to inflammation and infiltration of activated immune cells into the synovial joint, characterised by a progressive destruction of cartilage and bone. Although today's treatment options are very effective for many patients, not all of them respond properly or have to reduce medications due to adverse effects. In these patients it is crucial to slow down bone loss and inflammation in a timely manner to prevent further damage. Here, low-dose radiotherapy (LD-RT) could be an option, as it has been shown to ameliorate inflammation and to reduce pain. Using the human <i>TNFα</i> transgenic (h<i>TNFα</i> tg) mouse model as an experimental model of inflammatory arthritis, we revealed that locally applied LD-RT attenuates inflammation in the joints. <h3>Objectives</h3> As little is known about the impact of LD-RT on bone metabolism, we thus focused on the effects of LD-RT on bone homeostasis. <h3>Methods</h3> Bone marrow-derived osteoclasts (OC) of h<i>TNFα</i> tg mice were differentiated using M-CSF and RANK-L and seeded either on plastic or bone slices prior to irradiation to investigate their numbers and function. Osteoblasts (OB) were differentiated from mouse calvariae, irradiated and analysed regarding their differentiation and function using alizarin red stain and qPCR. Hind legs of h<i>TNFα</i> tg mice were locally irradiated with 0.5 Gy of X-rays and consecutively analysed using histomorphological methods and µCT. <h3>Results</h3> Treatment of OC with LD-RT (0.5–2 Gy) lead to decreased differentiation and function, while OB showed increased mineralization after irradiation with 0.5 Gy. Further, no significant increase of <i>Acp5</i> and <i>catk</i> at 0.5 Gy was found in OC while OB showed a dose-dependent decrease in <i>RANK-L</i> and increase in <i>OPG</i> expression. Also, OPG secretion by OB was enhanced at 0.5 Gy and 1 Gy. Histomorphometric analyses showed a decrease of erosive areas and OC numbers in the paws of irradiated animals, a finding that was confirmed in µCT images. <h3>Conclusions</h3> We conclude that LD-RT is not only a valuable tool for reduction of inflammation, but also has beneficial effects in restoring a balanced bone homeostasis through increased OB mineralization and decreased OC function. In the future, placebo controlled studies are desirable in order to investigate the effects of LD-RT with focus on osteoimmunology in RA in the clinic. <h3>Acknowledgements</h3> Supported by the German Federal Ministry of Education and Research (GREWIS, 02NUK017G and GREWIS-alpha, 02NUK050E <h3>Disclosure of interest</h3> None declared
Exploration of Non-Daily Maintenance Dosing Regimens in Peanut Oral Immunotherapy
Authors: Kim Prescott, Kenneth Krantz, Kirsten Beyer, A. Wesley Burks, Thomas B. Casale, Jonathan O'B. Hourihane, Stacie M. Jones, Andrea Vereda, Brian P. Vickery, Daniel C. Adelman
Journal: Journal of Allergy and Clinical Immunology (2018)
Failures of Sacral Neuromodulation for Incontinence
Authors: Bilal Chughtai, Dominique Thomas, Tianyi Sun, Art Sedrakyan
Journal: JAMA Surgery (2018)

Failures of Sacral Neuromodulation for IncontinenceSacral neuromodulation (SNM) is increasingly used to treat lower urinary tract symptoms and bowel symptoms refractory to conventional therapy. 1 The US Food and Drug Administration approved the device in 1997, and the device was modified in 2006, which included a 50% reduction in size and an improvement in leads to decrease lead migration.These changes at least partially explain the more than 3.5-fold increase in the number of SNM procedures in the following 5 years. 2 While guidelines based on small clinical studies with highly selected patients report 50% or greater symptom improvement in most patients, 1,3,4 an early safety report using real world data found that a large number of reinterventions occurred in the Medicare population. 2 The indications for SNM use are growing despite the lack of evidence.Hence, we sought to determine the reintervention rate associated with treatment failures and device malfunctions at 1, 3, and 5 years after surgery.The secondary aim was to evaluate the volume-outcome relationship.
La technique du pont: drainage endoscopique du foie droit par le foie gauche pour les sténoses hilaires malignes
Authors: C Bosshardt, F Caillol, E Francioni, E Bories, C Pesenti, JP Ratone, M Giovannini
Journal: Endoscopy (2018)

Le drainage biliaire par cholangiopancréatografie rétrograde endoscopique (CPRE) est le gold standard dans le cadre d'obstruction biliaire maligne chez les patients souffrant d'un ictère. Cependant après un échec de CPRE, les alternatives sont le drainage percutané radiologique, la chirurgie, et plus récemment l'hépaticogastrostomie sous échoendoscopie. La limite de cette technique est la limitation du drainage aux voies gauches. L'objectif de notre étude était d'évaluer l'efficacité et l'utilité d'un drainage complexe, du foie droit dans le foie gauche, et du foie gauche à l'estomac ou au jéjunum dans le même temps opératoire.
Risk Factors for Fecal Urgency Among Individuals With and Without Diarrhea, Based on Data From the National Health and Nutrition Examination Survey
Authors: Vikram Rangan, Shuji Mitsuhashi, Prashant Singh, Sarah Ballou, William Hirsch, Thomas Sommers, Judy Nee, Johanna Iturrino, Anthony Lembo
Journal: Clinical Gastroenterology and Hepatology (2018)
HDL in CKD—The Devil Is in the Detail
Authors: Florian Kronenberg
Journal: Journal of the American Society of Nephrology (2018)

The picture of HDL cholesterol (HDL-C) as the “good” cholesterol has eroded. This is even more surprising because there exists strong evidence that HDL-C is associated with cardiovascular disease (CVD) in the general population as well as in patients with impairment of kidney function and/or progression of CKD. However, drugs that dramatically increase HDL-C have mostly failed to decrease CVD events. Furthermore, genetic studies took the same line, as genetic variants that have a pronounced influence on HDL-C concentrations did not show an association with cardiovascular risk. For many, this was not surprising, given that an HDL particle is highly complex and carries &gt;80 proteins and several hundred lipid species. Simply measuring cholesterol might not reflect the variety of biologic effects of heterogeneous HDL particles. Therefore, functional studies and the involvement of HDL components in the reverse cholesterol transport, including the cholesterol efflux capacity, have become a further focus of study during recent years. As also observed for other aspects, CKD populations behave differently compared with non-CKD populations. Although clear disturbances have been observed for the “functionality” of HDL particles in patients with CKD, this did not necessarily translate into clear-cut associations with outcomes.
Abstract 33: Instrumental Variables Regression to Account for Bias in Associations Between the Food Environment and Diet Quality in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Authors: Pasquale E Rummo, David K Guilkey, Shu Wen Ng, Katie A Meyer, Jared P Reis, James M Shikany, Penny Gordon-Larsen
Journal: Circulation (2016)

Introduction: Although observational evidence suggests that the food environment is associated with diet behaviors, the literature is inconsistent. Most studies ignore potential bias due to healthier people selecting healthier residential neighborhoods and healthier food outlets locating in areas where there is demand. Hypotheses: Greater availability of fast food restaurants (vs. full-service restaurants) and convenience stores and grocery stores (vs. supermarkets) is associated with lower diet quality, accounting for potential bias. Methods: We used 20 years (1985-6; 1992-3; 2005-6) of data from CARDIA study (n=26,203 observations) with geographically-linked, time-varying neighborhood-level data. Using instrumental-variables regression with a generalized method of moments estimator, we estimated the longitudinal association between the percent of neighborhood fast food restaurants, full-service restaurants, convenience stores, grocery stores, and supermarkets (per total food outlets within 1-km network distance of respondents’ residences at each exam) and an a priori diet quality score, with higher scores indicating higher diet quality. We adjusted for individual-level sociodemographics, health behaviors, baseline study center, exam year, and total other food outlets. We included theoretically-justified instrumental variables related to neighborhood-level sociodemographics, road connectivity, physical activity facilities, and housing prices. Results: Across exam years the mean diet quality score was 64.3 (SD=12.8; range: 24-107). Relative to the percent of neighborhood full-service restaurants, a 10% increase in the density of fast food restaurants (mean=12.3; SD=13.0) was associated with a lower a priori diet quality score over time (β=-3.5; 95% CI=-6.0, -0.90; p=0.01), after adjusting for potential residential selection and purposeful store placement. However, relative to the percent of supermarkets, neither the percent of convenience stores (β=-0.85; 95% CI=0.12, -1.93; p=0.12), nor grocery stores (β=-0.72; 95% CI=-1.70, -0.26; p=0.15), was associated with diet quality. Conclusions: Compared to standard regression models, our findings suggest that efforts to reduce the availability of neighborhood fast food restaurants, but not other types of food outlets, may be associated with minor improvements to diet behaviors. This suggests that the selective nature of where people and stores locate may influence associations of the food environment with diet quality.
Is There a Future for Ovarian Cancer Screening?
Authors: Steven A. Narod
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Performances du diagnostic optique des polypes colo-rectaux avec le système Blue Laser Imaging: étude prospective sur 237 gastro-entérologues avant et après formation spécifique
Authors: B Brieau, S Ribière, M Barret, S Leblanc, B Bordacahar, C Leandri, MA Guillaumot, R Coriat, F Prat, S Chaussade
Journal: Endoscopy (2018)

Le diagnostic optique des polypes colo-rectaux est un enjeu majeur formation des gastroentérologues. Il permet 1-de différencier les polypes hyperplasiques des adénomes et d'appliquer la stratégie «detect and leave» (polypes hyperplasiques laissés en place) ou de résection sans analyse histologique (stratégie «discard» pour les petits adénomes de moins de 5 mm de diamètre) (1), 2-d'évaluer le risque de cancer au sein d'un polype et d'évaluer la profondeur d'invasion d'un cancer dont dépend la résécabilité endoscopique et le choix de la technique de résection (dissection sous-muqueuse versus mucosectomie versus chirurgie), 3-de prédire la prochaine coloscopie de surveillance en se basant sur la taille et la nature des polypes observés. Ces stratégies nécessitent une formation spécifique des endoscopistes juniors ou seniors. Un autre système de coloration virtuelle, le BLI (Blue Laser Imaging – Fujifilm), a montré des résultats comparables au NBI dans une étude japonaise réalisée par des endoscopistes experts: la performance diagnostique du BLI était de 74% versus 77,8% avec le NBI. En revanche, il existe peu de données concernant les performances diagnostiques d'endoscopistes naifs avec le BLI (2). L'objectif de notre étude était d'évaluer les performances diagnostiques d'endoscopistes naifs avec le système BLI, avant et après une formation dédiée courte.
Improving animal research: PREPARE before you ARRIVE
Authors: Adrian J Smith, R Eddie Clutton, Elliot Lilley, Kristine E Aa Hansen, Trond Brattelid
Journal: BMJ (2018)

Despite widespread journal endorsement of reporting guidelines, the poor reproducibility of preclinical research is increasingly under debate.1234 Ritskes-Hoitinga and Wever cite preregistration, systematic reviews, and better reporting as major tools for raising standards of animal research.5

An elephant in the room has been ignored for too long—better reporting does not improve the quality of an experiment that has already been …
Case Series Of Cross-Intolerance Reactions To Nonsteroidal Anti-Inflammatory Drugs In Children And Adolescents In Our Allergy Unit
Authors: Ana Gonzalez Moreno, Wendy Vargas Porras, María Del Mar Moro, Ana M. Nieto, Monica Rodriguez, Maria Dolores Alonso Diaz De Durana, Sabela Perez Codesido, Martina Privitera
Journal: Journal of Allergy and Clinical Immunology (2018)
A photosensitive liposome with NIR light triggered doxorubicin release as a combined photodynamic-chemo therapy system
Authors: Qingpo Li, Wei Li, Haixiao Di, Lihua Luo, Chunqi Zhu, Jie Yang, Xiaoyi Yin, Hang Yin, Jianqing Gao, Yongzhong Du, Jian You
Journal: Journal of Controlled Release (2018)
Administration of two doses of an oral, irreversible inhibitor of Bruton’s tyrosine kinase (BTK) to food allergic adults abrogates skin test responses and eliminates IgE-mediated basophil activation ex vivo
Authors: Melanie C. Dispenza, Jacqueline A. Pongracic, Anne Marie Singh, Bruce S. Bochner
Journal: Journal of Allergy and Clinical Immunology (2018)
Taux de détection d'adénomes en fonction de l'âge: Et s'il fallait débuter le dépistage dès 45 ans?
Authors: D Karsenti, G Tharsis, F Venezia, P Cattan, G Tordjman, A Gillet, K Nahon-Uzan, J Samama, M Cavicchi
Journal: Endoscopy (2018)

Les sociétés savantes réservent leur programme de dépistage des patients à risque moyen de cancer colo-rectal (CCR) à la population comprise entre 50 à 75 ans. Mais, nous avons peu de données sur le taux de détection d'adénome (TDA) chez les sujets plus jeunes et il n'est pas rare en pratique de routine de dépister des polypes ou des CCR chez des patients de moins de 50 ans. Nous avons donc évalué de façon prospective sur l'ensemble des coloscopies effectuées dans notre centre sur 1 an, le taux de détection d'adénomes (TDA) et de néoplasies (TDN) en fonction de la tranche d'âge.
Fructose and sugar: A major mediator of non-alcoholic fatty liver disease
Authors: Thomas Jensen, Manal F. Abdelmalek, Shelby Sullivan, Kristen J. Nadeau, Melanie Green, Carlos Roncal, Takahiko Nakagawa, Masanari Kuwabara, Yuka Sato, Duk-Hee Kang, Dean R. Tolan, Laura G. Sanchez-Lozada, Hugo R. Rosen, Miguel A. Lanaspa, Anna Mae Diehl, Richard J. Johnson
Journal: Journal of Hepatology (2018)
Test diagnostique non invasif de morphométrie automatisée de l'histologie des polypes coliques
Authors: A Berger, E Metiver, G Hunault, C Cavaro-Ménard, A Clément
Journal: Endoscopy (2018)

En France, prés de 1,3 millions de coloscopies sont réalisées chaque année. Il s'agit de l'examen de référence pour la détection des lésions pré-cancéreuses. Près de la moitié correspond à des polypes hyperplasiques c'est-à-dire sans potentiel de dégénérescence carcinologique. A l'échelon national, les polypectomies des petits polypes hyperplasiques représentent donc un coût économique et sociétal considérable.
Urine Test for Tuberculosis in Development
Authors: Jennifer Abbasi
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal