tbuckley/cabot-search huggingface dataset:
Abstract 12038: A Family-focused and Literacy-sensitive Intervention to Improve Medication Adherence in Patients With Heart Failure
Authors: Jia-rong Wu, Barbara Mark
Journal: Circulation (2016)

Background: Medication nonadherence contributes to rehospitalization and death in heart failure (HF) patients, yet there is no intervention that improves and sustains adherence after intervention completion. Objective: To address the need for a more effective intervention, we combined a literacy sensitive approach that also incorporated family support in an educational counseling intervention. The purpose of the study was to pilot-test the effects of a fam ily-focused, lit eracy-sensitive ( FamLit ) intervention on improving and sustaining medication adherence in HF patients. Methods: A randomized controlled pilot trial was conducted on 43 HF patients and their family members (dyads) who were assigned to the FamLit intervention group or usual care attention-control group. All dyads had an in-person session at baseline and received bi-weekly phone booster calls for the 3 month intervention. The Medication Event Monitoring System (MEMS) was used to measure medication adherence continuously for 6 months (from baseline). Repeated measures analysis of variance (ANOVA) was used to analyze the data. Results: No differences on demographic and clinical factors between groups at baseline. After the intervention, patients in the FamLit group (n=24) had better medication adherence compared to the control group (n=19) as measured by the MEMS (84.96% vs. 79.9%). Repeated measures ANOVA showed that there was a significant group by time interaction (F=7.158, p=.011). Improvement of medication adherence was sustained from 3 to 6 months in the intervention group (84.96% to 84.67%, Figure) while medication adherence decreased in the control group (79.9% to 69.96%), reflecting the natural trajectory of medication adherence. Conclusion: Incorporating family support and providing easy-to-read educational material to both HF patients and their caregivers enhances medication adherence during the intervention and sustains adherence 3 months after intervention completion.
Cyclic peptide-poly(HPMA) nanotubes as drug delivery vectors: In vitro assessment, pharmacokinetics and biodistribution
Authors: Sophie C. Larnaudie, Joaquin Sanchis, Tri-Hung Nguyen, Raoul Peltier, Sylvain Catrouillet, Johannes C. Brendel, Christopher J.H. Porter, Katrina A. Jolliffe, Sébastien Perrier
Journal: Biomaterials (2018)
Polymorphisms in beta-defensin pathways and clinical outcomes in metastatic colorectal cancer patients treated with FOLFIRI-bevacizumab in two randomized phase III trials.
Authors: Madiha Naseem, Martin D Berger, Alberto Puccini, Ryuma Tokunaga, FRANCESCA BATTAGLIN, Afsaneh Barzi, Shivani Soni, Michelle McSkane, Shu Cao, Joshua Millstein, Wu Zhang, Fotios Loupakis, Sebastian Stintzing, Volker Heinemann, Alfredo Falcone, Heinz-Josef Lenz
Journal: Journal of Clinical Oncology (2018)

662 Background: Beta defensin 1 (DEFB1) and 2 (DEFB4A) are antimicrobial peptides secreted from colonic epithelial cells in response to inflammation. DEFB1 has been shown to serve as a tumor suppressor, whereas high concentrations of DEFB4A are linked with angiogenesis. This study examines the impact of single nucleotide polymorphisms (SNPs) in beta-defensin pathways in two independent phase III trials: FIRE-3 and TRIBE. Methods: The OncoArray database containing 530K SNP markers provided by Illumina was used to find associations between clinical outcomes and 10 functional SNPs from DEFB1, DEFB4A, PPARG, NFKB1, MUC2, and TLR4 genes. Patients treated with first-line FOLFIRI/bevacizumab (bev) in the randomized phase III FIRE-3 trial (n = 107) and TRIBE trial (n = 215) served as discovery and validation cohorts respectively. The FIRE-3 FOLFIRI and cetuximab (cet) arm served as a negative control (n = 129). Results: A total of 451 patients were included. The NFKB1 rs3821958 SNP showed significant association with OS and PFS in overall pts and those with left-sided CRC. Compared to pts carrying the mutant A allele, those with the wild-type G/G genotype had a shorter median OS (19 vs 40 mts) and PFS (9.2 vs 11.7 mts) in both univariate ((OS: HR = 2.32, 95%CI 1.21-4.42, p = 0.006) (PFS: HR = 1.93, 95%CI: 1.11-3.37, p = 0.014)) and multivariable analysis ((OS: HR = 2.90, 95%CI 1.47-5.70, p = 0.002) (PFS: HR = 2.08, 95%CI:1.18-3.67, p = 0.012)). This finding was validated in TRIBE, where carriers of G allele had shorter PFS in univariate analysis (HR = 1.44, p = 0.019). Opposite results were observed in pts receiving cet, where G/G carriers had improved OS in univariate analysis (HR = 0.46, p = 0.048). Pts with left-sided CRC who carried the wild-type allele had poorer OS and PFS in both trials. Conclusions: NFKB1 rs3821958 SNP is known to activate DEFB1 and is downstream of EGFR. Harboring a mutant allele in this SNP confers a mortality benefit in left-sided and overall pts treated with bev, and worsens OS in pts receiving cet. Hence, NFKB1 could serve as an important predictive biomarker. Future studies are warranted to further elucidate its role in colorectal cancer.
SUCCESSFUL ENDOSCOPIC REMOVAL OF A LARGE FIBROVASCULAR POLYP IN UPPER ESOPHAGUS
Authors: A Maynard, M Abu-Suboh Abadia, M Masachs Peracaula, J Armengol Bertoli Armengol Bertoli, A Benages Curell, MD Castillo Cejas, J Guevara Cubas, D Sihuay Diburga, M Pigrau Pastor, J Rámon Armengol Miro, J Dot Bach
Journal: Endoscopy (2018)

We present the case of a 44 year old female with chronic constipation; Gastroesophageal Reflux Disease (GERD) and dyspepsia manage with medical therapy. She presented to the emergency department with a 2 week history of progressive dysphagia to both solids and liquids and 4 kg weight loss. She also complained of nocturnal orthopnea. A chest X-ray, ECG and laboratory test were normal. A gastroduodenoscopy was performed showing a 1.5 cm maximal diameter pseudo pedunculated submucosal lesion that originated from the left pyriform sinus that prolapsed into the esophagus. She was derived to the otolaryngologist who after review direct laryngoscopy failed to visualize the lesion. A CT scan was ordered showing an occupying submucosal mass suggestive of a lipoma in the upper third esophagus.
ENDOSCOPY-ASSOCIATED INFECTIONS – A COMPREHENSIVE REVIEW OF LITERATURE WITH ANALYSIS OF TRANSMISSION CAUSES
Authors: J Boban, P Lenz, A Mellmann, I Herrmann, D Domagk
Journal: Endoscopy (2018)

In the past two years, transmission of carbapenem-resistant Enterobacteriaceae via duodenoscopes has attracted broad attention in the endoscopic community and also in media. Flexible endoscopes are considered “semi-critical” medical devices which are associated with an increased risk of infectious transmission. In this study, we performed a comprehensive literature review on endoscopy associated infections to receive a systematic overview on endoscopy-associated infections with the aim to illuminate the factors leading to an insufficient reprocessing of flexible endoscopes and to allow recommendations for quality improvement to minimize the risks of infections.
Optimal pain management for patients with cancer in the modern era
Authors: Bethann M. Scarborough, Cardinale B. Smith
Journal: CA A Cancer Journal for Clinicians (2018)

Abstract Pain is a common symptom among patients with cancer. Adequate pain assessment and management are critical to improve the quality of life and health outcomes in this population. In this review, the authors provide a framework for safely and effectively managing cancer‐related pain by summarizing the evidence for the importance of controlling pain, the barriers to adequate pain management, strategies to assess and manage cancer‐related pain, how to manage pain in patients at risk of substance use disorder, and considerations when managing pain in a survivorship population. CA Cancer J Clin 2018;68:182–196 . © 2018 American Cancer Society .
Defining Postoperative Opioid Needs Among Preoperative Opioid Users
Authors: Jennifer Hah, Tina Hernandez-Boussard
Journal: JAMA Surgery (2018)

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MANAGEMENT OF RESECTION OF LARGE COLONIC LESIONS IN A REAL-LIFE SETTING: THE SCALP STUDY
Authors: A Amato, F Radaelli, V Cennamo, E Di Giulio, L Fuccio, G Manes, O Tarantino, G Fiori, M De Bellis, A Buda, F Pigò, P Cesaro, P Occhipinti, G Feliciangeli, M Manno, P Dulbwcco, A Musso, G Gullotti, M Giardini, B Mangiavillano, S Paggi, C Hassan, A Repici
Journal: Endoscopy (2018)

Endoscopic resection of large colonic lesions (LCLs, > 20 mm) is effective and associated with low rate of complications when performed by trained endoscopists in resourced centers. Aim of present study is to evaluate the reproducibility of good performance of endoscopic resection of LCLs outside referral centers.
PER-PROCEDURE TRIDIMENSIONAL HIGH RESOLUTION ESOPHAGEAL MANOMETRY DURING PERORAL ENDOSCOPIC MYOTOMY FOR ACHALASIA
Authors: M Barret, MA Guillaumot, S Leblanc, F Prat, S Chaussade
Journal: Endoscopy (2018)

Peroral endoscopic myotomy (POEM) is a widely used technique for the treatment of achalasia. However, about 10% primary treatment failures are recorded. These failures could be explained by an insufficient length of the gastric myotomy. We assessed the feasibility a per-POEM manometric measurement to optimize the length of the gastric myotomy.
Differential ubiquitination in NETs regulates macrophage responses in systemic lupus erythematosus
Authors: Ana Barrera-Vargas, Diana Gómez-Martín, Carmelo Carmona-Rivera, Javier Merayo-Chalico, Jiram Torres-Ruiz, Zerai Manna, Sarfaraz Hasni, Jorge Alcocer-Varela, Mariana J Kaplan
Journal: Annals of the Rheumatic Diseases (2018)

To assess if ubiquitinated proteins potentially present in neutrophil extracellular traps (NETs) can modify cellular responses and induce inflammatory mechanisms in patients with systemic lupus erythematosus (SLE) and healthy subjects.We studied 74 subjects with SLE and 77 healthy controls. Neutrophils and low-density granulocytes were isolated, and NETs were induced. Ubiquitin content was quantified in NETs by western blot analysis, ELISA and immunofluorescence microscopy, while ubiquitination of NET proteins was assessed by immunoprecipitation. Monocyte-derived macrophages from SLE and controls were isolated and stimulated with NETs or ubiquitin. Calcium flux and cytokine synthesis were measured following these stimuli.NETs contain ubiquitinated proteins, with a lower expression of polyubiquitinated proteins in subjects with SLE than in controls. Myeloperoxidase (MPO) is present in ubiquitinated form in NETs. Patients with SLE develop antiubiquitinated MPO antibodies, and titres positively correlate with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score (P<0.01), and negatively correlate with complement components (P<0.01). Stimulation of monocyte-derived macrophages with NETs or with ubiquitin led to enhanced calcium flux. In addition, stimulation with NETs led to enhanced cytokine (tumour necrosis factor-α and interleukin-10) production in macrophages from patients with SLE when compared with controls, which was hampered by inhibition of NET internalisation by macrophages.This is the first study to find ubiquitinated proteins in NETs, and evidence for adaptive immune responses directed towards ubiquitinated NET proteins in SLE. The distinct differences in ubiquitin species profile in NETs compared with healthy controls may contribute to dampened anti-inflammatory responses observed in SLE. These results also support a role for extracellular ubiquitin in inflammation in SLE.
Abstract 10920: Programmed Ventricular Stimulation for Risk Stratification in the Brugada Syndrome: A Pooled Analysis
Authors: Jakub Sroubek, Vincent Probst, Andrea Mazzanti, Pietro Delise, Jesus Castro Hevia, Kimie Ohkubo, Alessandro Zorzi, Jean Champagne, Anna Kostopoulou, Xiaoyan Yin, Carlo Napolitano, David J Milan, Arthur Wilde, Frederic Sacher, Martin Borggrefe, Patrick T Ellinor, George Theodorakis, Isabelle Nault, Domenico Corrado, Ichiro Watanabe, Charles Antzelevitch, Giuseppe Allocca, Silvia Priori, Steven A Lubitz
Journal: Circulation (2015)

Introduction: The role of programmed ventricular stimulation (PVS) in identifying Brugada syndrome patients at highest risk for sudden death is uncertain. Objective: To investigate the utility of PVS to predict future cardiac arrests or ICD therapy for ventricular arrhythmias in Brugada syndrome patients. Methods: We performed a systematic review and pooled analysis of prospective observational studies of Brugada syndrome patients with no history of sudden cardiac arrest who underwent PVS. We estimated incidence rates and relative hazards of cardiac arrest or ICD shock. Results: We analyzed individual-level data from 8 studies, comprising 1312 patients who experienced 65 cardiac events (median follow-up of 38.3 months). A total of 527 patients were induced into arrhythmias with up to triple extrastimuli. Induction was associated with cardiac events during follow-up (HR 2.66, 95%CI 1.44-4.92, P&lt;0.001). Event risks were inversely proportional to the number of extrastimuli causing induction (HR for each fewer extrastimulus protocol relative to individuals not induced 1.69, 95%CI 1.25-2.29, P&lt;0.001). Annual event rates varied substantially by syncope history, presence of spontaneous type 1 ECG pattern, and arrhythmia induction (0.23%, 95%CI 0.05-0.68 [no induced arrhythmia with up to double extrastimuli]; 0.45%, 95%CI 0.01-2.49 [induced arrhythmia]) and highest risk occurring among individuals with syncope and spontaneous type 1 patterns (2.55%, 95%CI 1.58-3.89 [no induced arrhythmia]; 5.60%, 95%CI 2.98-9.58 [induced arrhythmia]; ( Figure ). Conclusion: In Brugada syndrome patients, arrhythmias induced with PVS associate with future ventricular arrhythmia risk. Induction with fewer extrastimuli is associated with higher risk. However, clinical risk factors are important determinants of arrhythmia risk, and lack of induction does not necessarily portend low ventricular arrhythmia risk particularly in patients with high-risk clinical features.
A SIMPLIFIED TABLE MIXING VALIDATED DIAGNOSTIC CRITERIA IS EFFECTIVE TO IMPROVE CHARACTERIZATION OF COLORECTAL LESIONS BY FELLOWS: THE CONECCT CLASSIFICATION
Authors: M Fabritius, J Jacques, JM Gonzalez, X Dray, E Coron, L Brenet-Defour, J Branche, C Lepage, L Poincloux, I Lienhart, J Rivory, JC Saurin, V Lépilliez, T Ponchon, M Pioche
Journal: Endoscopy (2018)

Endoscopic characterization of colorectal neoplasia is a key point to choose in real time the best therapeutic option to treat effectively and safely each lesion. This characterization is based on 5 classifications, difficult to combine and to learn for non-experts. Thus, we mixed all the validated criteria in a single classification called CONECCT to facilitate prediction and therapeutic choice. This study aimed to evaluate CONECCT benefits in endoscopic characterization of colorectal neoplasia.
Abstract 12989: Generalizability of Quantitative Angiographic In-Segment Late Lumen Loss Imaging in Eastern and Western Populations: Can We Facilitate Global Drug Eluting Stent Evaluation?
Authors: Vaishnavi Radhakrishnan, John C Allen, Rebecca Fisher, Weng Kit Lye, Robert W Harrison, Mitchell W Krucoff
Journal: Circulation (2014)

Background: Regulators require mechanistic observations of late lumen loss (LLL) in evaluating new drug eluting stents (DES). Redundant requirements for follow-up catheterization across regulatory jurisdictions worldwide could be reduced if independent core laboratory quantitative coronary angiography (QCA) findings were generalizable. Our study aim was to assess comparability of QCA LLL in East (Japan, China) and West (N. America, Europe) pts using the world’s largest compilation of late follow-up QCA data. Hypothesis: The propensity adjusted mean difference in QCA in-segment LLL between East and West is ≤0.4mm, with 95% confidence. Methods: All available data from 4 manufacturers (7157 pts, 29 trials) reporting 6-12mo QCA LLL were compiled. East vs West were compared unadjusted and via propensity score (PS) quartiles that adjusted for 26 clinical descriptive and anatomic variables affecting QCA LLL. Of the 7157 pts, 6163 (86%) had complete covariable profiles and comprised the analysis set. Based on consensus of experts and regulators, a clinically meaningful difference between East and West mean IS-LLL was prospectively set at 0.4mm. Results: Of 6163 pts, 4134 were West and 2029 East, including 2304 paclitaxel, 1455 everolimus, 1562 zotarolimus, 440 sirolimus and 402 biolimus exposures. Unadjusted and adjusted IS-LLL (Mean±SD) was 0.25±0.47 (W) and 0.08±0.41 (E), and 0.24±0.45 (W) and 0.13±0.45 (E), respectively; differences (95% CI) were 0.17 (0.15, 0.19) and 0.12 (0.08, 0.16), respectively. PS-adjusted IS-LLL is shown the Figure. All differences were ≤ 0.4mm. Conclusion: In the world’s largest compilation of protocol follow-up across multiple DES platforms, QCA LLL appears generalizable and sufficiently predictive across East and West pts in both unadjusted and adjusted comparisons. This suggests that global DES evaluations can be facilitated by reducing the need for redundant invasive late catheterization across regulatory jurisdictions.
ERYTHROCYTE DISTRIBUTION WIDTH (RDW) AND HELICOBACTER PYLORI (H. PYLORI) INFECTION: IS THERE AN ASSOCIATION?
Authors: B Çavuş, T Çavuş, B Akyüz Erdoğan, E Kumcu
Journal: Endoscopy (2018)

H. Pylori is thought to be associated with inflammation and anemia. Although RDW's relationship with many diseases and inflammatory processes has been investigated, there is no study in the literature to show its relationship with H. Pylori. We aimed to investigate the relationship between RDW and H. Pylori in this study.
AZATHIOPRINE AND ENDOSCOPIC MUCOSAL HEALING: ABOUT A SERIES OF 67 CASES
Authors: FZ Chabib, I Benelbarhdadi, FZ Ajana
Journal: Endoscopy (2018)

Endoscopic mucosal healing has now become a major therapeutic goal that seems to improve the prognosis of IBD. Immunosuppressive drugs play an important role in the treatment and maintenance of remission during IBD. The aim of our work is to evaluate the rate of endoscopic mucosal healing obtained with Azathioprine after a mean therapeutic retreat of 4 years.
ENDOSCOPIC CLOSURE OF ACUTE PERFORATIONS OF THE GASTROINTESTINAL TRACT IN ANIMAL MODELS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: A Gabr, N Ammar, M El Housini, C Summerton, M Rutter
Journal: Endoscopy (2018)

Acute perforations are one of the recognized complications of gastrointestinal endoscopy. Endoscopic closure has become a popular treatment, due to feasibility and the reduction of the burden of surgery, combined with the availability of various closure devices. We aim to assess the technical and clinical success and safety of endoscopic closure, in total, and for each endoscopic device used in closing acute perforations in animal models.
Efficacité de la dilatation hydrostatique des sténoses au cours de la maladie de Crohn
Authors: S Bizid, G Mohamed, H Ben Abdallah, M Fekih, N Abdelli, R Bouali
Journal: Endoscopy (2009)

Objectif: Evaluer l'innocuité et l'efficacitéà long terme de la dilatation hydrostatique des sténoses de localisation digestive haute et basse de la maladie de Crohn.
Successful endoscopic removal of an eroded gastric ring with subsequent endoscopic suturing of the luminal defect
Authors: Enad Dawod, Aleksey Novikov, Najib Nassani, Ming Xu, Monica Saumoy, Cheguevara Afaneh, Reem Sharaiha
Journal: Endoscopy (2017)

A 50-year-old woman with a history of Fobi Pouch Roux-en-Y gastric bypass (RYGB) presented to our hospital with abdominal pain, reflux, and significant weight loss. Initial endoscopic evaluation at an outside hospital revealed a Silastic ring that had eroded into the gastric pouch. The patient refused surgery and was referred to our institution for management.
COMPARISON OF ORAL SULFATE SOLUTION AND 2 LITERS POLYETHYLENE GLYCOL WITH ASCORBIC ACID IN SPLIT DOSES AS BOWEL PREPARATION FOR COLONOSCOPY: A RANDOMIZED SINGLE-BLINDED TRIAL
Authors: MG Choi, HH Lee, CH Lim, YK Cho, JM Park, BI Lee, YS Cho
Journal: Endoscopy (2018)

This study aimed to evaluate the efficacy and tolerability oforal sulfate solution (OSS) and 2-L polyethylene glycol with ascorbic acid (PEG+Asc) in split doses for bowel cleansing prior to colonoscopy.
ENDOSCOPIC SUBMUCOSAL DISSECTION OR HYBRID-ESD FOR COLORECTAL SUPERFICIAL LESIONS? RETROSPECTIVE ANALYSIS OF A SERIES OF 101 PATIENTS
Authors: S Greco, M Campanale, C Spada, V La Vaccara, L Petruzziello, G Costamagna
Journal: Endoscopy (2018)

Endoscopic Submucosa dissection (ESD) is considered the gold standard for endoscopic resection of superficial colorectal neoplastic lesions > 20 mm and local adenomatous recurrence. However, ESD is a highly complex and time consuming procedure. In order to simplify it, the Hybrid-ESD (h-ESD) has been proposed as an alternative technique. It consists in circonferencial incision and partial submucosal dissection followed by the use of a snare for final resection. The aim of our study is to analyse, retrospectively, data on ESD and h-ESD resection for superficial colorectal lesions, in order to asses safety and efficacy of h-ESD and consider this procedure as a valid simplification of classical ESD
PSEUDOINVASION, A HISTOLOGICAL DIAGNOSIS TO CONSIDER IN THE ENDOSCOPIC SUBMUCOSAL DISSECTION
Authors: M Rodríguez-Téllez, MF Guerra Veloz, VA Jiménez García, AA Belda Cuesta, P Hergueta Delgado, Á Caunedo Álvarez, T Matsuda
Journal: Endoscopy (2018)

A 34-year-old female patient, referred to our center for endoscopic submucosal dissection (ESD) of non-granular laterally spreading rectal tumor (LST-NG) of 20 × 30 mm, with a central depression (paris 0-IIa+IIc) (Photo 1). After characterization by endoscopist with more than 300 ESD (photo 2), he performed this technique during a Live-Endoscopy in vivo. LST was resected in a piecemeal, because the lesion had a depression with severe fibrosis and could not be lifted enough. The histological findings showed a tubular adenoma with signs of pseudoinvasion, discarding after the complete analysis any foci of high grade dysplasia or adenocarcinoma.
CLINICAL EFFICACY AND ADVERSE EVENTS OF FULLY COVERED SELF-EXPANDABLE METAL STENTS (FC-SEMS) IN PANCREATOBILIARY STENOSIS
Authors: C Huertas, M Figa, M Hombrados, H Uchima, D Busquets, C Luz Rosales, M Albert, L Peries, L Gutiérrez, X Aldeguer
Journal: Endoscopy (2018)

To analyze indications, clinical efficacy, technical incidences and complications of fully covered self-expandable metal stents (FC-SEMS) in pancreatobiliary diseases in a terciary center.