tbuckley/cabot-search huggingface dataset:
Meta-analysis of LDL-C Lowering and Mortality—Reply
Authors: Jennifer G. Robinson, Eliano P. Navarese, Felicita Andreotti
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GW29-e0334 The relationship between the index of microcirculatory resistance and myocardial injury and cardiac function in patients with STEMI
Authors: Liyun He, Xingbang Liu, Ming Cui, Jiangli Han, Yongzhen Zhang, Jie Niu, Guisong Wang, Xinye Xu, Yupeng Wang, Fangfang Wang, Lijun Guo
Journal: Journal of the American College of Cardiology (2018)
Abstract IA38: Progress and unanswered questions in EGFR mutation-positive lung cancer
Authors: Lecia V. Sequist
Journal: Clinical Cancer Research (2018)

Abstract A summary of the major advances in management of EGFR mutation-positive lung cancer will be provided, along with a discussion of missing pieces of information that could improve the care of patients. Citation Format: Lecia V. Sequist. Progress and unanswered questions in EGFR mutation-positive lung cancer [abstract]. In: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; Jan 8-11, 2018; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(17_Suppl):Abstract nr IA38.
GW29-e1311 The investigation of essential hypertension in Wa minorities in Gengma County of yunnan province and analyzation of the risk factors
Authors: Shijie Liu, Yan He, Qin Ni, Wenhui Yang, Lulu Gan, Changhuan Mu, Yang Dong, Qin Wang, Fan Zhang, Li Yang
Journal: Journal of the American College of Cardiology (2018)
Differences in Characteristics and Clinical Outcomes Among Hispanic/Latino Men and Women Receiving HIV Medical Care — United States, 2013–2014
Authors: Ruth E. Luna-Gierke, R. Luke Shouse, Qingwei Luo, Emma Frazier, Guangnan Chen, Linda Beer
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

The prevalence of diagnosed human immunodeficiency virus (HIV) infection among Hispanics/Latinos in the United States is approximately twice that of non-Hispanic whites (1). Barriers to, and experiences with, medical care have been found to vary by sex (2). Describing characteristics of Hispanics/Latinos in care by sex can help identify disparities and inform delivery of tailored services to this underserved population. Data from the 2013 and 2014 cycles of the Medical Monitoring Project (MMP) were analyzed to describe demographic, behavioral, and clinical characteristics among Hispanics/Latinos by sex. MMP is an annual cross-sectional, nationally representative surveillance system that, during 2013-2014, collected information about behaviors, medical care, and clinical outcomes among adults receiving outpatient HIV care. Hispanic/Latina women were significantly more likely than were men to live in poverty (78% versus 54%), report not speaking English well (38% versus 21%), and receive interpreter (27% versus 16%), transportation (35% versus 21%), and meal (44% versus 26%) services. There were no significant differences between Hispanic/Latino women and men in prescription of antiretroviral therapy (ART) (95% versus 96%) or sustained viral suppression (68% versus 73%). Although women faced greater socioeconomic and language-related challenges, the clinical outcomes among Hispanic/Latina women were similar to those among men, perhaps reflecting their higher use of ancillary services. Levels of viral suppression for Hispanics/Latinos are lower than those found among non-Hispanic whites (3) and lower than the national prevention goal of at least 80% of persons with diagnosed HIV infection. Providers should be cognizant of the challenges faced by Hispanics/Latinos with HIV infection in care and provide referrals to needed ancillary services.
Supramolecular Nanofibers of Drug‐Peptide Amphiphile and Affibody Suppress HER2+ Tumor Growth
Authors: Chunhui Liang, Lushuai Zhang, Wene Zhao, Linlin Xu, Yaoxia Chen, Jiafu Long, Fuqiang Wang, Ling Wang, Zhimou Yang
Journal: Advanced Healthcare Materials (2018)

Abstract Antibody‐based medicines and nanomedicines are very promising for cancer therapy due to the high specificity and efficacy of antibodies. However, antibody‐drug conjugates and antibody‐modified nanomaterials frequently suffer from low drug loading and loss of functions due to the covalent modification of the antibody. A novel and versatile strategy to prepare supramolecular nanomaterials by the coassembly of an affibody (antiHER2) and drug‐peptide amphiphiles is reported here. During the enzyme‐instructed self‐assembly process, the drug‐peptide amphiphile can coassemble with the affibody, resulting in supramolecular nanofibers in hydrogels. The drug loading in the supramolecular nanofibers is high (&gt;30 wt%), and the stability of antiHER2 is significantly improved in the nanofibers at 37 °C (&gt;15 d in vitro). The supramolecular nanofibers exhibit high affinity for HER2+ cancer cells and can be efficiently taken up by these cells. In a mouse tumor model, the supramolecular nanofibers abolish HER2+ NCI‐N87 tumor growth due to the good accumulation and retention of nanofibers in tumor. This study provides a novel strategy to prepare nanomedicines with high drug loading and high specificity.
Outcome of progestin therapy in patients with endometrial cancer recurrence
Authors: Kaori Yoriki, Taisuke Mori, Hiroshi Matsushima, Tetsuya Kokabu, Shiori Umemura, Hiroshi Tatsumi, Haruo Kuroboshi, Morio Sawada, Jo Kitawaki
Journal: Annals of Oncology (2018)
Abstract A17: Methylation profile of SEPT9, NDRG4, p16 genes in colorectal cancer
Authors: Thais Sobanski, Lidia Arantes, Wellington dos Santos, Ronilson Durães, Marcus Matsushita, Rui Manuel Reis, Denise Peixoto Guimaraes
Journal: Clinical Cancer Research (2018)

Abstract Background: Colorectal cancer (CRC) is the third most common cancer in Brazil, where it appears as the fifth most deadly cancer. Brazilian National Cancer Institute estimates for the year of 2016 in Brazil 16,660 newly diagnosed cases of CRC in men and 17,620 in women. There is evidence that the incidence and mortality rates can be reduced through the detection of precursor lesions and early cancer in the context of CRC screening. Aberrant hypermethylation of cancer-related genes has emerged as a promising strategy for the molecular CRC screening. However, the methylation profile of colorectal cancer of the Brazilian population has limited information about its characterization and frequency. Objective: To investigate the frequency of DNA methylation in the promoter region of tumor suppressor genes SEPT9, NDRG4, and CDKN2A (p16) in sporadic CRCs of Brazilian patients. Methods: Retrospective molecular analysis included 57 adult patients with CRC in different clinical stages attended at the Barretos Cancer Hospital. Demographic, clinical, and tumor-related characteristics were obtained from medical records. DNA was extracted from fresh-frozen tumor tissues. Levels of DNA methylation were determined by quantitative pyrosequencing. Results: The mean ± SD age of the 57 patients' analysis was 64.40 ±14 years; 56.14% (32/57) were males. Almost all tumors (56/57; 98.24%) were located in the left side of the colon, from descending colon to rectum. Regarding stage, 3/57 (5.26%) were stage 0, 15/57 (26.31 %) stage I, 27/57 (47.36%) stage II, 10/57 (17.54%) stage III, and 2/57 (3.53%) stage IV tumors. Among 57 analyzed, 52/57 (91.22%) were methylated for SEPT9, 42/57 (73.68%) for NDRG4, and 15/57 (26.31%) for CDKN2A. In conclusion, in our Brazilian case series, the gene SEPT9 and NDGR4 showed high frequency of methylation CRC tissues, similar with results found in other populations. Citation Format: Thais Sobanski, Lidia Arantes, Wellington dos Santos, Ronilson Durães, Marcus Matsushita, Rui Manuel Reis, Denise Peixoto Guimaraes. Methylation profile of SEPT9, NDRG4, p16 genes in colorectal cancer [abstract]. In: Proceedings of the AACR International Conference held in cooperation with the Latin American Cooperative Oncology Group (LACOG) on Translational Cancer Medicine; May 4-6, 2017; São Paulo, Brazil. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(1_Suppl):Abstract nr A17.
GW29-e1127 Differences in two-year outcomes for patients with non‒ST-segment elevation myocardial infarction or unstable angina treated with medication only - findings from the EPICOR Asia study
Authors: Juan Zhou, Xin Huang, Ning Guo, Yue Wu, Bo Yu, Shubin Qiao, Jiyan Chen, Yaling Han, Junbo Ge, Stuart J. Pocock, Yong Huo, Zuyi Yuan
Journal: Journal of the American College of Cardiology (2018)
P3.09-26 Concordance of Surgical Resections and Fine Needle Biopsy-Derived Cell Block Sections for PD-L1 22C3 Immunohistochemistry
Authors: J. Schwock, H.M. Ko, J. Weiss, C. Cheung, S. Boerner, M. Tsao
Journal: Journal of Thoracic Oncology (2018)
Neuroendocrine carcinoma of the urinary bladder: A large analysis of the French GETUG consortium
Authors: M. Sroussi, M. Lorcet, M.P. Tardy, M. Guerin, F. Estrade, R. Delva, P. Barthelemy, P. Lavaud, Y. Neuzillet, N. Penel, N. Houede, D. Pouessel, E. Mussat, M. Gross Goupil, H. Gauthier, A. Gobert, O. Huillard, Y. Allory, R.-T. Elaidi, S. Oudard
Journal: Annals of Oncology (2018)
Identification and Replication of Six Loci Associated With Gallstone Disease
Authors: Helene Gellert‐Kristensen, Nawar Dalila, Sune Fallgaard Nielsen, Børge Grønne Nordestgaard, Anne Tybjærg‐Hansen, Stefan Stender
Journal: Hepatology (2018)

Gallstone disease is a common complex disease that confers a substantial economic burden on society. The genetic underpinnings of gallstone disease remain incompletely understood. We aimed to identify genetic associations with gallstone disease using publicly available data from the UK Biobank and two large Danish cohorts. We extracted genetic associations with gallstone disease from the Global Biobank Engine (GBE), an online browser of genome-wide associations in UK Biobank participants (14,940 cases and 322,268 controls). Significant associations (P < 5 × 10-8 ) were retested in two Copenhagen cohorts (comprising 1,522 cases and 18,266 controls). In the Copenhagen cohorts, we also tested whether a genetic risk score was associated with gallstone disease and whether individual gallstone loci were associated with plasma levels of lipids, lipoproteins, and liver enzymes. We identified 19 loci to be associated with gallstone disease in the GBE. Of these, 12 were replicated in the Copenhagen cohorts, including six previously unknown loci (in hepatocyte nuclear factor 4 alpha [HNF4A], fucosyltransferase 2, serpin family A member 1 [SERPINA1], jumonji domain containing 1C, AC074212.3, and solute carrier family 10A member 2 [SLC10A2]) and six known loci (in adenosine triphosphate binding cassette subfamily G member 8 [ABCG8], sulfotransferase family 2A member 1, cytochrome P450 7A1, transmembrane 4 L six family member 4, ABCB4, and tetratricopeptide repeat domain 39B). Five of the gallstone associations are protein-altering variants, and three (HNF4A p.Thr139Ile, SERPINA1 p.Glu366Lys, and SLC10A2 p.Pro290Ser) conferred per-allele odds ratios for gallstone disease of 1.30-1.36. Individuals with a genetic risk score >2.5 (prevalence 1%) had a 5-fold increased risk of gallstones compared to those with a score <1.0 (11%). Of the 19 lithogenic loci, 11 and ten exhibited distinct patterns of association with plasma levels of lipids and liver enzymes, respectively. Conclusion: We identified six susceptibility loci for gallstone disease.
GW29-e1468 Pacing Parameters and Success Rate of Permanent His Bundle Pacing in Patients with Narrow QRS: From A Single Center Experience
Authors: None Lan su, Shengjie Wu, Songjie Wang, Zhengxian Wang, Fangyi Xiao, Peiren Shan, Hao Zhou, Zhouqing Huang, Lei Xu, Weijian Huang
Journal: Journal of the American College of Cardiology (2018)
Re: Black–White Breast Cancer Incidence Trends: Effects of Ethnicity
Authors: Carol E DeSantis, Ahmedin Jemal
Journal: JNCI Journal of the National Cancer Institute (2018)

We read with interest the report by Davis Lynn et al. (1) that breast cancer incidence rates in non-Hispanic white (NHW) and non-Hispanic black (NHB) women did not recently converge.This differs from our previous analysis of long-term breast cancer trends based on data from the nine oldest Surveillance, Epidemiology, and End Results (SEER) registries that found rates converged between black women and white women in 2012 (2).Indeed, we agree with the authors that it is important to consider ethnicity when examining race-specific trends; however; this information was not available in the SEER 9 database.Thus, we extended our previous analysis using data on female breast cancer cases for all ages combined from the North American Association of Central Cancer Registries (NAACCR), which includes information from 43 states with high-quality data during 2002 to 2014, representing 92% of the US population (3).We adjusted the data for reporting delays using race-specific delay ratios from the 18 SEER registries, because delay factors are not publicly available for the combined NAACCR catchment area.Figure 1.Trends in breast cancer incidence rates in non-Hispanic white and non-Hispanic black women 2002 to 2014 in the NAACCR 43 states and SEER 13 registries.NH ¼ non-Hispanic.Symbols represent annual rates and 95% confidence intervals are indicated by shaded bands.Stars ¼ NH whites; diamonds ¼ NH blacks.Rates are age adjusted to the US standard population and have been adjusted to account for delays in case reporting.
Abstract 11239: Fat and Lean Mass Distributions and Cardiovascular and All-cause Mortality in Older Adults: the Cardiovascular Health Study
Authors: Aferdita Spahillari, Kenneth Mukamal, Jorge R Kizer, John S Gottdiener, Luc Djoussé, Mary F Lyles, Traci M Bartz, Venkatesh L Murthy, Ravi V Shah
Journal: Circulation (2016)

Introduction: Understanding contributions of fat and lean tissue to cardiovascular and all-cause cardiovascular mortality may help clarify areas of prevention in older adults Hypothesis: We hypothesized that greater fat and lower lean mass would be associated with a higher risk of mortality. Methods: A total of 1335 participants of the Cardiovascular Health Study who underwent dual-energy x-ray absorptiometry (DEXA) scans were included. We used principal components analysis (PCA) to define two independent sources of variation in DEXA-derived body composition, corresponding to principal components composed of fat (“fat PC”) and lean (“lean PC”) tissue. We used Cox proportional hazards regression using these PCs to investigate the relationship between body composition and mortality. Results: Mean age was 76.2±4.8 years (56% women) with mean body mass index 27.1±4.4 kg/m 2 . In spline models, fat PC had a non-linear association with mortality in unadjusted but not adjusted models; lean PC was associated with mortality risk linearly. The lowest quartile of the fat PC (least adiposity) was associated with a greater hazard of all-cause mortality (HR = 1.24, 95% CI 1.04-1.48, P=0.02) relative to fat PCs between the 25 th -75 th percentile, but the highest quartile did not have a significantly greater hazard (P=0.70). A greater lean PC was associated with lower all-cause (HR=0.91, 95% CI 0.84-0.98, P=0.01) and cardiovascular mortality (HR=0.84, 95% CI 0.74-0.95, P=0.005). Conclusions: Greater lean tissue mass is associated with improved cardiovascular and overall mortality in the elderly. The lowest levels of fat tissue mass are linked with adverse prognosis, but the highest levels show no significant mortality protection. Prevention efforts in the elderly frail may be best targeted toward improvements in lean muscle mass.
Immediate vs Delayed Pushing During the Second Stage of Labor
Authors: Jeffrey D. Sperling, Dana R. Gossett
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Assessment and initial management of suspected behavioural insomnia in pre-adolescent children
Authors: Catherine M Hill, Hazel Everitt
Journal: BMJ (2018)

### What you need to know

About 20-30% of parents and caregivers (hereafter referred to as parents) in the developed world report that their children have insomnia (difficulty falling asleep or staying asleep).1234 Reliable data from developing countries is lacking, but adult data suggests that insomnia is a global phenomenon.5 Children born this millennium are likely to sleep for around 70 minutes less each night than generations born 100 years ago.6 Insomnia in children is a public health concern, because short sleep is associated with multiple adverse outcomes (table 1). Numerous meta-analyses confirm the link between short sleep and childhood obesity,131415 behavioural problems,7 and poor school performance.11 A population based prospective cohort study has also associated sleep disturbance after 2 years of age with reduced grey matter volume at 7 years old.19

View this table:

Table 1 
Adverse outcomes associated with short sleep in children



The effect on parents is also important. As little as one week of sleep disruption in children affects parents’ mood, emotional regulation, and decision making, and it can take months or years for them to seek help.2021

Parents are generally understanding when a child has short-lived or acute insomnia, such as after a period of illness or the birth of a sibling. However, when insomnia is chronic (defined as occurring for ≥3 nights a week for ≥3 …
JAVELIN PARP medley: A phase Ib/II study of avelumab (anti–PD-L1) plus talazoparib in locally advanced or metastatic solid tumors
Authors: T.A. Yap, J.T. Beck, R.A. Stewart, S.C. Dahm, C. Chappey, R. Cesari, A. Scheuber, M.D. Galsky, D. Wise
Journal: Annals of Oncology (2018)
Mouse Models for Cancer Immunotherapy Research
Authors: Brian Olson, Yadi Li, Yu Lin, Edison T. Liu, Akash Patnaik
Journal: Cancer Discovery (2018)

Abstract Immunotherapy has revolutionized cancer therapy, largely attributed to the success of immune-checkpoint blockade. However, there are subsets of patients across multiple cancers who have not shown robust responses to these agents. A major impediment to progress in the field is the availability of faithful mouse models that recapitulate the complexity of human malignancy and immune contexture within the tumor microenvironment. These models are urgently needed across all malignancies to interrogate and predict antitumor immune responses and therapeutic efficacy in clinical trials. Herein, we seek to review pros and cons of different cancer mouse models, and how they can be used as platforms to predict efficacy and resistance to cancer immunotherapies. Significance: Although immunotherapy has shown substantial benefit in the treatment of a variety of malignancies, a key hurdle toward the advancement of these therapies is the availability of immunocompetent preclinical mouse models that recapitulate human disease. Here, we review the evolution of preclinical mouse models and their utility as coclinical platforms for mechanistic interrogation of cancer immunotherapies. Cancer Discov; 8(11); 1358–65. ©2018 AACR.
Re: Kersten et al.: Orbital “blowout” fractures: time for a new paradigm (Ophthalmology. 2018;125:796-798)
Authors: Margaret L. Pfeiffer, Mica Y. Bergman, Helen A. Merritt, David B. Samimi, Steven C. Dresner, Michael A. Burnstine
Journal: Ophthalmology (2018)
Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients
Authors: Attila Feher, Ajay Srivastava, Michael A. Quail, Nabil E. Boutagy, Pravien Khanna, Lynn Wilson, Edward J. Miller, Yi-Hwa Liu, Forrester Lee, Albert J. Sinusas
Journal: JACC. Cardiovascular imaging (2018)

This study aimed to evaluate the long-term prognostic value of serial assessment of coronary flow reserve (CFR) by rubidium Rb 82 (