AB1310 Anti-mÜllerian hormone and vitamin d serum levels in women with rheumatoid arthritis
Authors: I. Perez Onofre, C.M. Skinner Taylor, L. Perez Barboza, M. Erguia Bernal, D.A. Galarza Delgado, J.L. Riega Torres
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Anti-Müllerian hormone (AMH) is a marker for ovarian reserve, whose levels when found decreased suggest compromise of the fertility. The AMH gene promoter contains a vitamin D reponse element that may cause vitamin D status to influence serum AMH levels, vitamin D has an influence in the activity of Rheumatoid Arthritis (AR) since it has been found that patients with autoimmune diseases show lower serum levels of this vitamin in comparison of normal controls. The current study examined the vitamin D status and AMH levels in women with RA. <h3>Objectives</h3> Evaluate serum levels of vitamin D and AMH in women with RA and in control group. <h3>Methods</h3> Observational, cross-sectional, study conducted between May and July 2017 at the University Hospital "Dr. José E. González " in Mexico. We included 38 women between 18 and 39 years of age, they met diagnostic criteria for RA established by the ACR in 2010, excluding pregnant patients, with primary amenorrhea or known risk factors for diminished ovarian reserve. A control group of 38 healthy age-matched women was integrated. Serum AMH level was measured using ELISA method in commercial kit (AMH Gen II, Beckman Coulter, Brea, CA, EU) as well the 25-hydroxyitamin D [25(OH)D)] status using chemiluminescence immunoassay. To analyse differences between the groups, we used Mann-Whitney U test; Spearman correlation coefficients were calculated between AMH level and Vitamin D level. Values are shown as the mean ±SD. Two-sided <i>P</i> values less than 0.05 were considered significant. The statistical package used was SPSS Statistics, V17(Chicago: SPSS Inc.) <h3>Results</h3> It was found a mean age of 34.42 (<i>SD</i>=5.43) and 31.47 years (<i>SD</i>=5.72) in the control group and in women with RA, respectively. Regard the mean serum levels of Vitamin D it was reported 20.04(<i>SD</i>=7.81) in control group and 23.55(<i>SD</i>=8.2) in women with RA. In control group, it was reported a mean of AMH of 2.83(<i>SD</i>=0.47) and in women with RA a mean of 2.63(<i>SD</i>=0.50). Serum levels of Vitamin D of patients with RA were statistically significant compared with the control group (p=0.015) and AMH were statistically significant in women with RA compared with the control group (p=0.052)<i>(Table1)</i>. There was no significant correlation between serum levels of vitamin D and AMH (p=0.795). <h3>Conclusions</h3> The current study shows that AMH and Vitamin D levels are lower in RA patients compared with controls. However, results do not indicate significant correlation between serum levels of vitamin D and AMH. So, it is suggested more studies. <h3>References</h3> [1] Azzeh F, Kensara O. Vitamin D Is a Good Marker for Disease Activity of Rheumatoid Arthritis Disease. Dis Markers. 2015;2015:260725. [2] Brouwer J, Laven JSE, Hazes JMW, Schipper I, Dolhain RJEM. Levels of anti-mullerian hormone, a marker for65:1534–8. <h3>Disclosure of Interest</h3> None declared