tbuckley/cabot-search huggingface dataset:
Baseline hyperglycemia was predictive of poor outcome in pleural malignant mesothelioma
Authors: J.C. Ruffinelli, J.C. Pardo, S. Recalde, J.C. Benítez, L. Cancel, R. Palmero, R. Llatjós, M.R. Escoda, S. Padrones, I. Brao, E. Dalmau, Y. Garcia, F. Cardenal, E. Nadal
Journal: Annals of Oncology (2017)
肺に調節可能な持続放出する片面乳剤法を介した大多孔性PLGAナノ粒子工学におけるポリビニルピロリドンの検証:In vitro,in vivo特性評価
Authors: Ni Rui, Muenster Uwe, Zhao Jing, Zhang Lan, Becker-Pelster Eva-Maria, Rosenbruch Martin, Mao Shirui
Journal: Journal of Controlled Release (2017)
Targeted radiopeptide therapy Re188-P2045 to treat neuroendocrine lung cancer.
Authors: Christopher Peter Adams, Wasif M. Saif
Journal: Journal of Clinical Oncology (2017)

e20016 Background: : Despite the recent success of checkpoint inhibitors, there continues to be a significant medical need for lung cancer therapies that can be directed to the patients most likely to respond. Somatostatin receptor subtype 2 (SSTR2) is the most widely up-regulated subtype in both small and non-small cell lung cancers and is also expressed in tumoral (but not mature) blood vessels. Peptide targeted radiotherapy has advantages over traditional targeted therapies in that targeted tumor cells as well as surrounding cancer cells and supporting stroma are selectively killed. This study was conducted to determine the ability of Rhenium Re 188 P2045, a radiolabeled somatostatin analog specific for SSTR2 to both image (to select the most appropriate patients) and treat lung cancer patients who over-express somatostatin receptors. Methods: In an open label, single arm study, refractory lung cancer patients to standard of care therapy were identified by image analysis using Rhenium Re 188 P2045, a radiolabeled somatostatin analog. 25 Patients received the imaging dose of 10uCi of Re188 and 265ng of peptide by intravenous injection. Three patients were selected based on high SSTR expression levels to receive 30uCi of Re188 P2045 as a therapeutic dose 14 days after imaging. Patients were followed for 8 weeks post treatment. Results: The imaging study revealed a high density of expression of the somatostatin receptor in the lungs of patients. Patients in the imaging and therapeutic treatment groups reported no adverse advents or signs of toxicity. The image analysis using Re188 P2045 was compared to CT images and demonstrated accurate detection of lung tumor lesions. The images obtained using Re188 P2045 were of sufficiently high quality to enable identification of receptor expression at the tumor site as shown in Figures 1&amp;2. Conclusions: Rhenium Re 188 P2045, a radiolabeled somatostatin analog, may be used to both identify and treat lung cancer tumors. The ability to image and dose patients with the same targeted molecule enables a personalized medicine approach and this highly targeted patient therapy may significantly improve treatment of tumors that over express somatostatin receptor.
Development, Validation, and Dissemination of a Breast Cancer Recurrence Detection and Timing Informatics Algorithm
Authors: Debra P Ritzwoller, Michael J Hassett, Hajime Uno, Angel M Cronin, Nikki M Carroll, Mark C Hornbrook, Lawrence C Kushi
Journal: JNCI Journal of the National Cancer Institute (2017)

This study developed, validated, and disseminated a generalizable informatics algorithm for detecting breast cancer recurrence and timing using a gold standard measure of recurrence coupled with data derived from a readily available common data model that pools health insurance claims and electronic health records data. The algorithm has two parts: to detect the presence of recurrence and to estimate the timing of recurrence. The primary data source was the Cancer Research Network Virtual Data Warehouse (VDW). Sixteen potential indicators of recurrence were considered for model development. The final recurrence detection and timing models were determined, respectively, by maximizing the area under the ROC curve (AUROC) and minimizing average absolute error. Detection and timing algorithms were validated using VDW data in comparison with a gold standard recurrence capture from a third site in which recurrences were validated through chart review. Performance of this algorithm, stratified by stage at diagnosis, was compared with other published algorithms. All statistical tests were two-sided. Detection model AUROCs were 0.939 (95% confidence interval [CI] = 0.917 to 0.955) in the training data set (n = 3370) and 0.956 (95% CI = 0.944 to 0.971) and 0.900 (95% CI = 0.872 to 0.928), respectively, in the two validation data sets (n = 3370 and 3961, respectively). Timing models yielded average absolute prediction errors of 12.6% (95% CI = 10.5% to 14.5%) in the training data and 11.7% (95% CI = 9.9% to 13.5%) and 10.8% (95% CI = 9.6% to 12.2%) in the validation data sets, respectively, and were statistically significantly lower by 12.6% (95% CI = 8.8% to 16.5%, P < .001) than those estimated using previously reported timing algorithms. Similar covariates were included in both detection and timing algorithms but differed substantially from previous studies. Valid and reliable detection of recurrence using data derived from electronic medical records and insurance claims is feasible. These tools will enable extensive, novel research on quality, effectiveness, and outcomes for breast cancer patients and those who develop recurrence.
Pandemic H1N1 influenza surveillance in Victoria, Australia, April – September, 2009
Authors: J E Fielding, N Higgins, J E Gregory, K A Grant, M G Catton, I Bergeri, R A Lester, H A Kelly
Journal: Eurosurveillance (2009)

Victoria was the first Australian state to report widespread transmission of pandemic H1N1 2009 influenza. Notifiable laboratory-confirmed influenza and a general practitioner sentinel surveillance system measuring influenza-like illness (ILI), including laboratory confirmation of influenza as the cause of ILI, were used to assess the pandemic. The pandemic influenza A(H1N1)v virus quickly became the dominant circulating strain and notification rates were highest in children and young adults. Despite a high number of notified cases, comparison of ILI rates suggested the season peaked in late June, was similar in magnitude to 2003 and 2007 and less severe than 1997. The majority of clinical presentations were mild, but one quarter of hospitalised cases required admission to intensive care. Given the low proportion of imported cases in the Victorian pandemic, the rapid increase in cases with no travel history and the low median age of cases notified during the phases of intense surveillance, we suggest there may have been silent importations of pandemic virus into Victoria before the first case was recognised. The usefulness of a general practitioner sentinel surveillance system to provide a comparable assessment of influenza and ILI activity over time was clearly demonstrated, and the need for similar hospital and mortality surveillance systems for influenza in Victoria was highlighted.
Low grade glioma patients with IDH mutation and 1p19q codeletion: What to do after surgery?
Authors: E. Franceschi, A. Mura, A. Mandrioli, S. Minichillo, A. Tosoni, A. Pession, D. De Biase, D. Danieli, S. Pizzolitto, A. Fioravanti, L. Volpin, R. Agati, S. Bartolini, A. Paccapelo, A.A. Brandes
Journal: Annals of Oncology (2017)
Surveillance of Zika virus infection in the EU/EEA, June 2015 to January 2017
Authors: G Spiteri, B Sudre, A Septfons, J Beauté
Journal: Eurosurveillance (2017)

Surveillance of Zika virus (ZIKV) infection in the European Union/European Economic Area (EU/EEA) was implemented in 2016 in response to the large outbreak reported in the Americas in 2015 associated with an increased number of infants born with microcephaly. Between June 2015 and January 2017, 21 EU/EEA countries reported 2,133 confirmed cases of ZIKV infection, of whom 106 were pregnant women. Cases infected in the Caribbean constituted 71% of reported cases. Almost all cases (99%) were most probably infected by mosquito bite during travel outside continental Europe, while only 1% were transmitted sexually. Considering that 584 imported cases were reported between May and October 2016 among residents of areas with established presence of Aedes albopictus, the absence of autochthonous vector-borne cases suggests that Ae. albopictus is not an efficient vector for ZIKV infection.
Circulating tumor cells (CTCs), molecular alterations and their correlation with characteristics of patients (pts) with metastatic colorectal cancer (mCRC) treated in the Spanish TTD VISNÚ Program
Authors: J. Sastre, V. de la Orden, A. Martínez, I. Bando, I. Santamaría, B. Bellosillo Paricio, S. Palanca, I. Peligros, B. Mediero, P. Llovet, V. Moreno, J.M. Viéitez, P. Garcia-Alfonso, S. Gil, M.J. Ortiz Morales, M.A. Salud Salvia, G. Quintero, F.A. Gesto, E. Aranda Aguilar, E. Diaz Rubio
Journal: Annals of Oncology (2017)
AMALTHEA: A prospective, single-arm study of the Hellenic Cooperative Oncology Group evaluating the efficacy and safety of 1st line FOLFIRI+Aflibercept in patients with metastatic colorectal cancer
Authors: G. Pentheroudakis, V. Kotoula, G-A. Koliou, I. Tikas, V. Karavasilis, E. Samantas, G. Aravantinos, E. Daskalaki, I. Souglakos, G. Koumakis, I. Efstratiou, C. Petraki, C. Poulios, D. Bafaloukos, D. Pectasides, E. Vrettou, G. Fountzilas
Journal: Annals of Oncology (2017)
Security of Text Messaging in Clinical Care
Authors: Brian G. Choi, Scott K. Intner
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An internet-supported school physical activity intervention in low socioeconomic status communities: results from the Activity and Motivation in Physical Education (AMPED) cluster randomised controlled trial
Authors: Chris Lonsdale, Aidan Lester, Katherine B Owen, Rhiannon L White, Louisa Peralta, Morwenna Kirwan, Thierno M O Diallo, Anthony J Maeder, Andrew Bennie, Freya MacMillan, Gregory S Kolt, Nikos Ntoumanis, Jennifer M Gore, Ester Cerin, Dylan P Cliff, David R Lubans
Journal: British Journal of Sports Medicine (2017)

Objective Quality physical education (PE) is the cornerstone of comprehensive school physical activity (PA) promotion programmes. We tested the efficacy of a teacher professional learning intervention, delivered partially via the internet, designed to maximise opportunities for students to be active during PE lessons and enhance adolescents’ motivation towards PE and PA. Methods A two-arm cluster randomised controlled trial with teachers and Grade 8 students from secondary schools in low socioeconomic areas of Western Sydney, Australia. The Activity and Motivation in Physical Education (AMPED) intervention for secondary school PE teachers included workshops, online learning, implementation tasks and mentoring sessions. The primary outcome was the proportion of PE lesson time that students spent in moderate-to-vigorous physical activity (MVPA), measured by accelerometers at baseline, postintervention (7–8 months after baseline) and maintenance (14–15 months). Secondary outcomes included observed PE teachers’ behaviour during lessons, students’ leisure-time PA and students’ motivation. Results Students (n=1421) from 14 schools completed baseline assessments and were included in linear mixed model analyses. The intervention had positive effects on students’ MVPA during lessons. At postintervention, the adjusted mean difference in the proportion of lesson time spent in MVPA was 5.58% (p&lt;0.001, approximately 4 min/lesson). During the maintenance phase, this effect was 2.64% (p&lt;0.001, approximately 2 min/lesson). The intervention had positive effects on teachers’ behaviour, but did not impact students’ motivation. Conclusions AMPED produced modest improvements in MVPA and compares favourably with previous interventions delivered exclusively face-to-face. Online teacher training could help facilitate widespread dissemination of professional learning interventions. Trial registration number ACTRN12614000184673.
GW28-e0660 Elevated Hs-CRP Level is Independently Associated with the Presence of Non-calcified or Mixed Coronary Atherosclerotic Plaques in Chinese Population Undergoing Coronary Computed Tomography Angiography
Authors: Tiewei Li, Rui Peng, Xiangfeng Cong, Xi Chen
Journal: Journal of the American College of Cardiology (2017)
Modified Glasgow prognostic score, prognostic nutritional index and ECOG score could be new prognostic factors for survival in metastatic gastric cancer
Authors: B. Demirelli, N. Babacan, S. Koca, B.N. Uzun, Ö. Ercelep, M.A. Ozturk, S. Kaya, E.T. Simsek, S. Khalil, R. Hasanov, O. Alan, T.A. Telli, M.E. Arıbal, F. Dane, F. Yumuk
Journal: Annals of Oncology (2017)
Abstract 17956: Stratification of Cardiac Electrophysiologic Phenotypes via Systematic Auditory Electrophysiology Evaluation
Authors: Sunil Kapur, Calum A MacRae
Journal: Circulation (2015)

It is well appreciated that overlap exists between cardiac and auditory electrophysiology, notably the classic example of Jervell Lange Neilson syndrome. We aimed to investigate if further insights into cardiac electrophysiology could be derived via auditory electrophysiology evaluation. We performed a retrospective chart review in the Partners Healthcare system from January 2001- May 2015 for patients who underwent at least 23 hours of a Holter recording as well as an auditory hearing evaluation. 55 patients were identified. Indications for auditory evaluation included patient complaint of hearing loss, symptomatic tinnitus and pre-neurosurgical evaluation. Indications for Holter recordings included complaint of palpitations and heart rate monitoring. Of the 55 patients, 26 (47%) had at least mild sensorineural defect in at least one ear while 28 (51%) had at least mild conductive defect in at least one ear. All auditory evaluations were interpreted by a clinical audiologist. Patients with sensorineural hearing defects had an increased percentage of total (summed atrial and ventricular) ectopic beats when compared to those without any hearing defects as well as those with conductive hearing defects (3.7% versus 0.3% versus 0.5% respectively, p&lt;0.05). The 9 patients (16%) with bilateral sensorineural loss had significant increase in atrial ectopy as a percent of total beats when compared to the 46 patients without bilateral sensorineural hearing loss (6.1% versus 1.1%, p&lt;0.05). Patients with bilateral sensorineural hearing defects had an increased prevalence of atrial fibrillation when compared to those without sensorineural hearing loss (44% vs 14%). In conclusion, a retrospective analysis of a small population of patients having undergone clinical auditory evaluation and Holter monitoring suggests that patients with bilateral sensorineural defects have increased atrial arrhythmias over controls. This finding serves as a hypothesis generating observation regarding the ability of non-cardiac electrophysiologic findings to characterize arrhythmic propensity. These observations further suggest that extracardiac electrophysiologic determinants exist that may be leveraged to better stratify arrhythmic risk.
The impact of co-culture of NSCLC tumor cells and fibroblasts on drug response
Authors: S. Abreu, V. Espírito Santo, A. Oleksijew, E. Oswald, M.F. Estrada, S.P. Rebelo, K. Vaidya, J. Schuler, P.M. Alves, E.R. Boghaert, C. Brito
Journal: Annals of Oncology (2017)
Real world comparison of common patient reported symptoms with health utility scores in cancer outpatients
Authors: M. Moskovits, K. Jao, C.M. Brown, S. Su, H. Naik, L. Eng, T. Wang, Y. Leung, W. Xu, G. Liu, M. Li, G. Devins, D. Howell
Journal: Annals of Oncology (2017)
Cancer patient attitudes and preferences towards smoking status assessment
Authors: L. Eng, S. Liu, Q. Zhang, D. Farzanfar, R. Milne, S. Yeung, C.M. Brown, D. Howell, W. Xu, D.P. Goldstein, J.M. Jones, P. Selby, M.E. Giuliani, G. Liu
Journal: Annals of Oncology (2017)
Salmonella enteritidis in Western Europe 1995-98 – a surveillance report from Enter-net
Authors: I. S.T. Fisher
Journal: Eurosurveillance (1999)

A decline in the incidence of Salmonella enteritidis infections in western Europe was identified by the Salm-Net (forerunner of Enter-net) salmonella database between 1993 and 1995, when the numbers of S. enteritidis isolates fell from 37 647 to 31 482. T
Vigilancia sindrómica basada en los servicios de urgencias y la mortalidad bruta : dos ejemplos
Authors: L Josseran, Javier Nicolau, N Caillère, P Astagneau, G Brücker
Journal: Eurosurveillance (2006)

Las recientes crisis sanitarias mostraron la necesidad de disponer rapidamente de informacion que facilite la gestion apropiada a los responsables. Los proveedores de datos mas apropiados para responder a esa necesidad son los profesionales que registran datos de forma rutinaria para sus actividades. Describimos aqui los resultados de un estudio piloto llevado a cabo por el InVS frances. (Institut national de veille sanitaire) basado en datos recogidos en servicios de urgencia hospitalarios y en registros civiles. 
Los datos de las urgencias provienen de servicios de urgencias informatizados y los datos de mortalidad del Instituto Nacional de Estadistica (Insee). Los datos son transmitidos diariamente. Se compararon los datos de gripe de los brotes 2004/05 y 2005/06 con los datos de la Red centinela para los mismos anos, observandose una correlacion significativa (pl0.001) entre los datos de los servicios de urgencias y los de la red centinela. Los datos de salud ambiental fueron comparados con las temperaturas parisienses de junio a agosto de 2006. Cada semana se hacia un analisis de la mortalidad. Para los datos relacionados con el calor, se observo una correlacion significativa entre ciertos diagnosticos y el aumento de la temperatura. Para ese tipo de fenomenos la mortalidad crece significativamente tras una a dos semanas. 
Es la primera vez, en nuestro conocimiento, que se lleva a cabo un estudio utilizando en tiempo real datos de morbilidad y mortalidad. Los primeros resultados muestran que estos datos se complementan unos con otros y que su analisis simultaneo en tiempo real permite medir rapidamente el impacto de un fenomeno.
Red española de vigilancia de la tuberculosis multirresistente
Authors: S Samper, M. J. Iglesias, O Tello
Journal: Eurosurveillance (2000)

La red espanola de vigilancia de la propagacion de la tuberculosis multirresistente mediante tipificacion genomica creada en enero de 1998 cuenta con la participacion de alrededor del 90% de los laboratorios del sistema sanitario nacional. De los 94 casos de tuberculosis multirresistente incluidos en el estudio de 1998, un 30% presentaba el mismo patron de RFLP. El veinte por ciento de los casos estaba coinfectado con VIH, siendo este porcentaje similar al observado en casos con tuberculosis sensible. El objetivo de la red es establecer un sistema de alerta precoz de la tuberculosis multirresistente en el ambito nacional.
Benefit of cetuximab addition to a platinum-fluorouracil-based chemotherapy in an unselected population of metastatic head and neck cancer patients and effect of KRAS Lcs6 variation on cetuximab response
Authors: V. Bastit, N. Bon-Mardion, J-M. Picquenot, V. Rainville, C. Moldovan, A. François, F. El Ouakif, F. Jardin, J-P. Marie, F. Di Fiore, F. Clatot
Journal: Annals of Oncology (2017)
Red Cell Distribution Width (RDW) at Diagnosis of Diffuse Large B-Cell Lymphoma (DLBCL) Is Associated to Higher Mortality and Worse Overall Survival
Authors: Leyre Bento, Juan Sarmentero, Ana Ortuño, Marta García-Recio, Bernardo Lopez, Jordi Martínez-Serra, Jose Rodriguez, Antonia Sampol, Antonio Gutierrez
Journal: Blood (2016)
A randomized Phase 2 study comparing different dosing approaches of induction treatment (first cycle) of regorafenib in metastatic colorectal cancer (mCRC) patients
Authors: G. Argilés Martinez, E. Sanz-Garcia, M. Valladares-Ayerbes, J.M. Viéitez, P. Garcia-Alfonso, C. Gravalos, M. Tobeña, G. Duran Ogaya, M.T. Cano Osuna, B. García-Paredes, C. Santos, M. Rodríguez-Garrote, F. Rivera Herrero, M.J. Safont, A. Falcone, F. Ciardiello, R. Goldberg, J. Bennouna, J. Tabernero, E. Aranda Aguilar
Journal: Annals of Oncology (2017)
Treatment of patients with substance use disorders
Authors: Herbert D. Kleber, Roger D. Weiss, Raymond F. Anton, Tony P. George, Shelly F. Greenfield, Thomas R. Kosten, Charles P. O'Brien, Bruce J. Rounsaville, Eric C. Strain, Douglas M. Ziedonis, Grace Hennessy, Hilary Smith Connery
Journal: American Journal of Psychiatry (2006)
Long-Term Outcomes in Patients With <i>BRAF</i> V600–Mutant Metastatic Melanoma Who Received Dabrafenib Combined With Trametinib
Authors: Georgina V. Long, Zeynep Eroglu, Jeffrey Infante, Sapna Patel, Adil Daud, Douglas B. Johnson, Rene Gonzalez, Richard Kefford, Omid Hamid, Lynn Schuchter, Jonathan Cebon, William Sharfman, Robert McWilliams, Mario Sznol, Suman Redhu, Eduard Gasal, Bijoyesh Mookerjee, Jeffrey Weber, Keith T. Flaherty
Journal: Journal of Clinical Oncology (2017)

Purpose To report 5-year landmark analysis efficacy and safety outcomes in patients with BRAF V600-mutant metastatic melanoma (MM) who received BRAF inhibitor dabrafenib (D) and MEK inhibitor trametinib (T) combination therapy versus D monotherapy in the randomized phase II BRF113220 study part C. Patients and Methods BRAF inhibitor-naive patients with BRAF V600-mutant MM were randomly assigned 1:1:1 to receive D 150 mg twice a day, D 150 mg twice a day plus T 1 mg once daily, or D 150 mg twice a day plus T 2 mg once daily (D + T 150/2). Patients who received D monotherapy could cross over to D + T 150/2 postprogression. Efficacy and safety were analyzed 4 and 5 years after initiation in patients with ≥ 5 years of follow-up. Results As of October 13, 2016, 18 patients who received D + T 150/2 remained in the study (13 [24%] of 54 enrolled at this dose plus five [11%] of 45 initially administered D who crossed over to D + T). With D + T 150/2, overall survival (OS; 4 years, 30%; 5 years, 28%) and progression-free survival (4 and 5 years, both 13%) appeared to stabilize with extended follow-up. Increased OS was observed in patients who received D + T with baseline normal lactate dehydrogenase (5 years, 45%) and normal lactate dehydrogenase with fewer than three organ sites with metastasis (5 years, 51%). With extended follow-up, one additional patient who received D + T 150/2 improved from a partial to a complete response. No new safety signals were observed. Conclusion This 5-year analysis represents the longest follow-up to date with BRAF + MEK inhibitor combination therapy in BRAF V600-mutant MM. Consistent with trends observed in landmark analyses with shorter follow-up, this therapy elicits durable plateaus of long-term OS and progression-free survival that last ≥ 5 years in some patients with MM.