tbuckley/cabot-search huggingface dataset:
A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow
Authors: Stephanie Rossnagl, Hiba Ghura, Christopher Groth, Eva Altrock, Franz Jakob, Sarah Schott, Pauline Wimberger, Theresa Link, Jan Dominik Kuhlmann, Arnulf Stenzl, Jörg Hennenlotter, Tilmann Todenhöfer, Markus Rojewski, Karen Bieback, Inaam A. Nakchbandi
Journal: Cancer Research (2017)

Abstract Breast and prostate cancer cells home to the bone marrow, where they presumably hijack the hematopoietic stem cell niche. We characterize here the elusive premetastatic niche by examining the role of mesenchymal stromal cells (MSC) in cancer cell homing. Decreasing the number of MSC pharmacologically enhanced cancer cell homing to the bone marrow in mice. In contrast, increasing the number of these MSCs by various interventions including G-CSF administration diminished cancer cell homing. The MSC subpopulation that correlated best with cancer cells expressed stem, endothelial, and pericytic cell markers, suggesting these cells represent an undifferentiated component of the niche with vascular commitment. In humans, a MSC subpopulation carrying markers for endothelial and pericytic cells was lower in the presence of cytokeratin+ cells in bone marrow. Taken together, our data show that a subpopulation of MSC with both endothelial and pericytic cell surface markers suppresses the homing of cancer cells to the bone marrow. Similar to the presence of cytokeratin+ cells in the bone marrow, this MSC subpopulation could prove useful in determining the risk of metastatic disease, and its manipulation might offer a new possibility for diminishing bone metastasis formation. Significance: These findings establish an inverse relationship between a subpopulation of mesenchymal stromal cells and cancer cells in the bone marrow. Cancer Res; 78(1); 129–42. ©2017 AACR.
A population-based prospective cohort study examining the influence of early-life respiratory tract infections on school-age lung function and asthma
Authors: Evelien R van Meel, Herman T den Dekker, Niels J Elbert, Pauline W Jansen, Henriëtte A Moll, Irwin K Reiss, Johan C de Jongste, Vincent W V Jaddoe, Liesbeth Duijts
Journal: Thorax (2017)

Background Early-life respiratory tract infections could affect airway obstruction and increase asthma risk in later life. However, results from previous studies are inconsistent. Objective We examined the associations of early-life respiratory tract infections with lung function and asthma in school-aged children. Methods This study among 5197 children born between April 2002 and January 2006 was embedded in a population-based prospective cohort study. Information on physician-attended upper and lower respiratory tract infections until age 6 years (categorised into ≤ 3 and &gt;3–6 years) was obtained by annual questionnaires. Spirometry measures and physician-diagnosed asthma were assessed at age 10 years. Results Upper respiratory tract infections were not associated with adverse respiratory outcomes. Compared with children without lower respiratory tract infections ≤3 years, children with lower respiratory tract infections ≤3 years had a lower FEV 1 , FVC, FEV 1 :FVC and forced expiratory flow at 75% of FVC (FEF 75 ) (Z-score (95% CI): ranging from −0.22 (−0.31 to –0.12) to −0.12 (−0.21 to −0.03)) and an increased risk of asthma (OR (95% CI): 1.79 (1.19 to 2.59)). Children with lower respiratory tract infections &gt;3–6 years had an increased risk of asthma (3.53 (2.37 to 5.17)) only. Results were not mediated by antibiotic or paracetamol use and not modified by inhalant allergic sensitisation. Cross-lagged modelling showed that results were not bidirectional and independent of preschool wheezing patterns. Conclusion Early-life lower respiratory tract infections ≤3 years are most consistently associated with lower lung function and increased risk of asthma in school-aged children.
Incidental Findings on Brain Imaging in the General Pediatric Population
Authors: Philip R Jansen, Marjolein Dremmen, Aaike van den Berg, Ilona A Dekkers, Laura M E Blanken, Ryan L Muetzel, Koen Bolhuis, Rosa M Mulder, Desana Kocevska, Toyah A Jansen, Marie-Claire Y de Wit, Rinze F Neuteboom, Tinca J C Polderman, Danielle Posthuma, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier, Aad van der Lugt, Tonya J H White
Journal: New England Journal of Medicine (2017)

Brain MRI in 3966 children from the population-based Generation R Study (mean age, 10.1 years) revealed incidental findings in 25.6%. Most findings did not require neurosurgical intervention, but 7 children (0.18%) had suspected primary brain tumors.
ECDC et OMS : une mission commune pour l'amélioration de la santé en Europe
Authors: M Danzon
Journal: Eurosurveillance (2004)

L'annee 2005 comptera en termes de sante publique en Europe, avec l'ouverture, en mai a Stockholm, du Centre europeen de prevention et de controle des maladies (ECDC). L'idee d'un CDC europeen est dans l'air depuis de nombreuses annees, suite aux excellents resultats obtenus par le CDC americain a Atlanta.
TCT-163 Long-term Clinical Outcomes of Patients with Chronic Kidney Disease and Critical Limb Ischemia underwent Percutaneous Transluminal Angioplasty
Authors: Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Won Young Jang, Woo Hyeun Kim, Eun Jin Park, Ja Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2017)
A randomized controlled trial comparing two vaso-occlusive episode (VOE) protocols in sickle cell disease (SCD)
Authors: Paula Tanabe, Susan Silva, Hayden B. Bosworth, Regina Crawford, Judith A. Paice, Lynne D. Richardson, Christopher N. Miller, Jeffrey Glassberg
Journal: American Journal of Hematology (2017)

Limited evidence guides opioid dosing strategies for acute Sickle Cell (SCD) pain. We compared two National Heart, Lung and Blood (NHBLI) recommended opioid dosing strategies (weight-based vs. patient-specific) for ED treatment of acute vaso-occlusive episodes (VOE). A prospective randomized controlled trial (RCT) was conducted in two ED's. Adults ≥ 21 years of age with SCD disease were eligible. Among the 155 eligible patients, 106 consented and 52 had eligible visits. Patients were pre-enrolled in the outpatient setting and randomized to one of two opioid dosing strategies for a future ED visit. ED providers accessed protocols through the electronic medical record. Change in pain score (0-100 mm VAS) from arrival to ED disposition, as well as side effects were assessed. 52 patients (median age was 27 years, 42% were female, and 89% black) had one or more ED visits for a VOE (total of 126 ED study visits, up to 5 visits/patient were included). Participants randomized to the patient-specific protocol experienced a mean reduction in pain score that was 16.6 points greater than patients randomized to the weight-based group (mean difference 95% CI = 11.3 to 21.9, P = 0.03). Naloxone was not required for either protocol and nausea and/or vomiting was observed less often in the patient-specific protocol (25.8% vs 59.4%, P = 0.0001). The hospital admission rate for VOE was lower for patients in the patient-specific protocol (40.3% vs 57.8% P = 0.05). NHLBI guideline-based analgesia with patient-specific opioid dosing resulted in greater improvements in the pain experience compared to a weight-based strategy, without increased side effects.
Touristes de retour en Suède comme population sentinelle pour comparer l’incidence de pathologies dans d’autres pays européens, l’exemple des infections à campylobacter et à giardia
Authors: K Ekdahl, J Giesecke
Journal: Eurosurveillance (2004)

Obtenir des donnees d’incidence comparables d’un pays a l’autre n’est pas toujours facile. C’est pourquoi nous avons compare les risques d’infection, chez les Suedois se rendant dans un autre pays d’Europe. A ete pris comme numerateur, le nombre de cas d’
Un pseudo-brote de infecciones humanas por A/H5N1 en Grecia y sus consecuencias en salud pública
Authors: G Spala, T Panagiotopoulos, N Mavroidi, X Dedoukou, A Baka, P Tsonou, E Triantafyllou, A Mentis, V Kyriazopoulou, A Melidou, S Tsiodras
Journal: Eurosurveillance (2006)

La reciente diseminacion geografica del virus de gripe aviar A/H5N1 altamente patogeno tiene consecuencias importantes en salud publica. En Grecia, la infeccion de varias aves migratorias se confirmo en febrero y marzo de 2006. El objetivo del articulo siguiente fue describir los datos procedentes de casos humanos potenciales de H5N1 que se presentaron en hospitales locales con una infeccion respiratoria durante este periodo, y expresaban su inquietud en relacion con una exposicion al virus de la gripe aviar. 
Se llevo a cabo un estudio caso-control. Los casos se seleccionaron por medio de una definicion estructurada, una revision de las caracteristicas epidemiologicas y clinicas y mediante la identificacion del virus de la gripe aviar A/H5N1 por analisis molecular. El ambito de estudio fue todo el pais para el periodo de febrero y marzo de 2006. Se esperaba obtener la tasa de casos posibles (los que respondian tanto a criterios clinicos como a epidemiologicos) y las caracteristicas clinicas o epidemiologicas que permitian diferenciarlos de los casos potenciales que respondian a uno solo de estos criterios, no a ambos. 
Veintiseis pacientes potenciales (de los cuales el 81% respondia a un criterio clinico y el 39% a un criterio epidemiologico) se presentaron durante el dicho periodo en hospitales locales donde la mayor parte (85%) fueron admitidos. La mayor parte de los casos (85%) se observaron en el norte de Grecia, donde fueron descritos la mayoria de los casos confirmados de gripe aviar A/H5N1. Cinco de los 26 pacientes estudiados correspondian a la definicion de caso posible. Todos ellos estaban agrupados en el periodo precoz de casos confirmados A/H5N1 en aves migratorias (P=0,05). El analisis molecular fue negativo para todos los casos posibles. El hecho de utilizar una definicion de caso revisada siguiendo las recomendaciones mas recientes de la Union Europea resulto en la exclusion de dos casos posibles. 
Como conclusion, se identificaron recientemente casos humanos potenciales de A/H5N1 en Grecia. El periodo de tiempo y su localizacion geografica sugieren un aumento de la conciencia de riesgo en la poblacion general y una interpretacion incorrecta de la definicion de caso por parte de los medicos.
Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease
Authors: J.T. Qiao, C. Cui, L. Qing, L.S. Wang, T.Y. He, F. Yan, F.Q. Liu, Y.H. Shen, X.G. Hou, L. Chen
Journal: Metabolism (2017)
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies
Authors: Siew C Ng, Hai Yun Shi, Nima Hamidi, Fox E Underwood, Whitney Tang, Eric I Benchimol, Remo Panaccione, Subrata Ghosh, Justin C Y Wu, Francis K L Chan, Joseph J Y Sung, Gilaad G Kaplan
Journal: The Lancet (2017)
Recombinant immunotoxins targeting B-cell maturation antigen are cytotoxic to myeloma cell lines and myeloma cells from patients
Authors: T K Bera, Y Abe, T Ise, A Oberle, D Gallardo, X-f Liu, S Nagata, M Binder, I Pastan
Journal: Leukemia (2017)

Recombinant immunotoxins targeting B-cell maturation antigen are cytotoxic to myeloma cell lines and myeloma cells from patients
Abstract 16097: Comparison of Outcomes for Patients With Chronic Kidney Disease Treated With Pre-Hospital Reduced Dose Fibrinolytic Followed by Urgent Percutaneous Coronary Intervention versus Percutaneous Coronary Intervention Alone for Treatment of ST-Elevation Myocardial Infarction
Authors: Amirreza Solhpour, Kay-Won Chang, Richard W Smalling, Stefano Sdringola, Prakash Balan, H Vernon Anderson, Ali E Denktas
Journal: Circulation (2013)

Background:  Pre-hospital administration of reduced-dose fibrinolytic restores coronary patency prior to urgent percutaneous coronary intervention (PCI) but it could be associated with stroke or bleeding risk, especially in patients with chronic kidney disease (CKD) for whom recurrence of stroke and bleeding hazards may be increased. For over 7 years we have used a strategy of field evaluation for STEMI using 12 lead EKGs obtained and transmitted by emergency services (EMS) personnel with over-read by emergency center physicians. Appropriate STEMI patients receive pre-hospital reduced dose fibrinolytic (10 units reteplase) along with aspirin, clopidogrel, and heparin, and are transported to our STEMI center for urgent PCI (FAST-PCI strategy).   Methods:  We examined the data for CKD patients (ie, glomerular filtration rate  2  for 3 months or more) treated by either a FAST-PCI strategy or primary PCI (PPCI). We compared demographic, clinical, angiographic data and outcomes. Ischemic time was defined as time from onset of pain to device activation. Bleeding was assessed using GUSTO criteria.   Results:  Between May 2006 and February 2013, we treated 1258 STEMI patients of which 199 (15.8%) had CKD. FAST-PCI was employed in 84 (42%) and PPCI in 115 (58%) patients. Both groups were comparable in age, cardiac risk factors and ischemic time. Data are shown in the table.   Conclusions:  The FAST-PCI strategy reduced 30 day mortality among CKD patients with STEMI, without increasing the risk of stroke or bleeding, compared to PPCI. It was also associated with earlier infarct-related artery patency and decreased the incidence of shock at presentation.
Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition
Authors: Josine M. Quispel-Janssen, Jitendra Badhai, Laurel Schunselaar, Stacey Price, Jonathan Brammeld, Francesco Iorio, Krishna Kolluri, Matthew Garnett, Anton Berns, Paul Baas, Ultan McDermott, Jacques Neefjes, Constantine Alifrangis
Journal: Clinical Cancer Research (2017)

Abstract Purpose: Despite intense research, treatment options for patients with mesothelioma are limited and offer only modest survival advantage. We screened a large panel of compounds in multiple mesothelioma models and correlated sensitivity with a range of molecular features to detect biomarkers of drug response. Experimental design: We utilized a high-throughput chemical inhibitor screen in a panel of 889 cancer cell lines, including both immortalized and primary early-passage mesothelioma lines, alongside comprehensive molecular characterization using Illumina whole-exome sequencing, copy-number analysis and Affymetrix array whole transcriptome profiling. Subsequent validation was done using functional assays such as siRNA silencing and mesothelioma mouse xenograft models. Results: A subgroup of immortalized and primary MPM lines appeared highly sensitive to FGFR inhibition. None of these lines harbored genomic alterations of FGFR family members, but rather BAP1 protein loss was associated with enhanced sensitivity to FGFR inhibition. This was confirmed in an MPM mouse xenograft model and by BAP1 knockdown and overexpression in cell line models. Gene expression analyses revealed an association between BAP1 loss and increased expression of the receptors FGFR1/3 and ligands FGF9/18. BAP1 loss was associated with activation of MAPK signaling. These associations were confirmed in a cohort of MPM patient samples. Conclusions: A subgroup of mesotheliomas cell lines harbor sensitivity to FGFR inhibition. BAP1 protein loss enriches for this subgroup and could serve as a potential biomarker to select patients for FGFR inhibitor treatment. These data identify a clinically relevant MPM subgroup for consideration of FGFR therapeutics in future clinical studies. Clin Cancer Res; 24(1); 84–94. ©2017 AACR.
Salmonella Enteritidis fagotipo 29 na Austria : uma opportunidade para considerar a relevância da carne de frango como fonte de infecções humanas por salmonella
Authors: C Berghold, C. Kornschober, I Lederer, F Allerberger
Journal: Eurosurveillance (2004)

Assumindo que os diversos fagotipos de Salmonella Enteritidis (S. Enteritidis) sao igualmente virulentos, pode-se estimar a importancia de certas comidas como fonte de infeccoes para salmonelosis humanas segundo as diferencas na distribuicao dos fagotipos nas amostras humanas e nao-humanas. Em Austria, foi isolado pela primeira vez em 2002 S. Enteritidis de fagotipo 29 em amostras nao-humanas. Foi identificado esse fagotipo em 44 de 159 estirpes (27,7%), provindo de amostras veterinarias de galinhas ou de seu entorno (carne, miudos, amostras du galinheiro e das fezes). Na carne vendida ao detalhe (frango, figado), cinco dos 38 isolamentos de S. Enteritidis, eram de fagotipo 29. A proporcao do mesmo fagotipo nas amostras humanas era muito inferior, representando apenas 0,40% de todos isolamentos de S. Enteritidis em 2002 (30 isolamentos primarios humanos) e 0,33% em 2003 (23 isolamentos primarios humanos). A nossa opiniao e que a diferenca entre a alta prevalencia de S. Enteritidis nos frangos e na carne de frango e o numero restrinto de casos humanos de S. Enteritidis mostra que os frangos de origem austriaca nao sao uma fonte importante de infeccoes humanas por S. Enteritidis.
Abstract 15233: The Lesion Length Gives a Better Effect on the Fractional Flow Reserve Than the Minimal Luminal Area in the Intermediate Coronary Artery Lesion
Authors: Yoon Juneyoung, Xiongjie Jin, Kyong-Woo Seo, Jin-sun Park, Hyoung-Mo Yang, Jung Rae Cho, Hong-Seok Lim, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Juyong Lee, Gyo-Seung Hwang, Joon-Han Shin, Seoung-Jea Tahk
Journal: Circulation (2015)

Introduction: The pressure gradient of the circulation fluid in a stenosis area depends on minimal luminal area (MLA) of the stenosis, lesion length (LL), and the fluid velocity. However, the correlation of the LL and the MLA; the cutoff values are uncertain. Hypothesis: LL and MLA differently influences the FFR. Methods: We studied 117 patients with intermediate coronary artery disease who underwent FFR and IVUS measurement out of 302 patients in FAVOR study. This study was a prospective, 1:1 randomized, open label multicenter trial to demonstrate the clinical outcomes between FFR and IVUS-guided PCI. Inclusion criteria were as follows: 1)Angina or documented silent ischemia 2) De novo intermediate coronary artery disease (30-70% diameter stenosis) by visual estimation, 3) Reference vessel diameter ≥ 3.0mm by visual estimation. We excluded left main disease, MI, EF&lt; 40%, and graft vessel. There were no significant differences in baseline clinical characteristics. The mean values are the QCA (54.3±14.0 %), MLA (3.6±1.4 mm2) and LL (20.6±1.4mm), respectively. We were performed the path analysis using AMOS 18, and estimated the ROC curve in SPSS 18. Results: Standardized estimates were the LL -0.47,QCA -0.28 and MLA -0.21 (R2=0.594, p&lt;0.000) in path analysis. The model is recursive and statistically significant. The FFR was ≤0.80 in 47 lesions (31%). The optimal LL for an FFR of ≤0.80 was 15.8mm (90% sensitivity, 50% specificity, 44% positive predictive value, 87% negative predictive value, area under the curve: 0.75, 95% CI: 0.66 to 0.85; p &lt; 0.001) and MLA 3.9mm (sensitivity 86%, specificity 59%, 35% positive predictive value , 94% negative predictive value, area under the curve: 0.78, 95% CI: 0.67 to 0.85; p &lt; 0.001) Conclusions: The lesion length influenced more the FFR than MLA. The lesion length ≥ 15.8mm and MLA ≤ 3.9mm are risk zones, which need to be confirm the functional status with FFR because of the low positive predictive value
Total pancreatectomy of pancreatic cancer with slowly progressive type1 DM after chemotherapy of GEM+ Nab-paclitaxel
Authors: Ayako Suzuki, Shinsuke Funakoshi, Mai Hoshino, Keiichirou Saigusa, Ryuhei Kishino, Yutaka Shimoyama, Gen Sakai, Atsushi Nakazawa, Nobuhiro Tsukada, Shigemichi Hirose
Journal: Annals of Oncology (2017)
Insights into Epigenetic Remodeling in VHL-Deficient Clear Cell Renal Cell Carcinoma
Authors: Christopher J. Ricketts, W. Marston Linehan
Journal: Cancer Discovery (2017)

Abstract Summary: Clear cell renal cell carcinoma (ccRCC) is characterized by loss of the von Hippel–Lindau tumor suppressor gene (VHL), and the functional tumorigenic consequences of this loss have been used to develop therapies for advanced ccRCC, such as targeting activation of the HIF pathway. Yao and colleagues elucidate how VHL loss contributes to chromatin alteration at both gene promoters and enhancers/superenhancers, in both an HIF-dependent as well as independent manner, and how this may provide additional targets for therapeutic intervention in advanced ccRCC. Cancer Discov; 7(11); 1221–3. ©2017 AACR. See related article by Yao et al., p. 1284.
Normal-Tension Glaucoma Has Normal Intracranial Pressure
Authors: Christina Lindén, Sara Qvarlander, Gauti Jóhannesson, Elias Johansson, Fanny Östlund, Jan Malm, Anders Eklund
Journal: Ophthalmology (2017)

PurposeTo test the hypothesis that normal-tension glaucoma (NTG) is caused by an increased pressure difference across the lamina cribrosa (LC) related to a low intracranial pressure (ICP).DesignProspective case-control study.ParticipantsThirteen NTG patients (9 women; median 71 [range: 56–83] years) were recruited for investigation with the same protocol as 11 healthy volunteers (8 women; 47 [30–59] years). A larger control group (n = 51; 30 women; 68 [30–81] years) was used only for ICP comparison in supine position.MethodsICP and intraocular pressure (IOP) were simultaneously measured in supine, sitting, and 9° head-down tilt (HDT) positions. Trans–lamina cribrosa pressure difference (TLCPD) was calculated using ICP and IOP together with geometric distances estimated from magnetic resonance imaging to adjust for hydrostatic effects.Main Outcome MeasuresICP, IOP, and TLCPD in different body positions.ResultsBetween NTG patients and healthy volunteers, there were no differences in ICP, IOP, or TLCPD in supine, sitting, or HDT (P ≥ 0.11), except for IOP in HDT (P = 0.04). There was no correlation between visual field defect and TLCPD, IOP, or ICP and in any body position (P ≥ 0.39). Mean ICP in supine was 10.3 mmHg (SD = 2.7) in the NTG group (n = 13) and 11.3 (2.2) mmHg in the larger control group (n = 51) (P = 0.24).ConclusionsThere was no evidence of reduced ICP in NTG patients as compared with healthy controls, either in supine or in upright position. Consequently, the hypothesis that NTG is caused by an elevated TLCPD from low ICP was not supported.
A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets
Authors: Masaki Imai, Tokiko Watanabe, Maki Kiso, Noriko Nakajima, Seiya Yamayoshi, Kiyoko Iwatsuki-Horimoto, Masato Hatta, Shinya Yamada, Mutsumi Ito, Yuko Sakai-Tagawa, Masayuki Shirakura, Emi Takashita, Seiichiro Fujisaki, Ryan McBride, Andrew J. Thompson, Kenta Takahashi, Tadashi Maemura, Hiromichi Mitake, Shiho Chiba, Gongxun Zhong, Shufang Fan, Kohei Oishi, Atsuhiro Yasuhara, Kosuke Takada, Tomomi Nakao, Satoshi Fukuyama, Makoto Yamashita, Tiago J.S. Lopes, Gabriele Neumann, Takato Odagiri, Shinji Watanabe, Yuelong Shu, James C. Paulson, Hideki Hasegawa, Yoshihiro Kawaoka
Journal: Cell Host & Microbe (2017)