FRI0373 Long-term follow-up of 320 children born to mothers with systemic autoimmune diseases: a multicentre italian survey from 24 rheumatology centres
Authors: M.G. Lazzaroni, C. Nalli, L. Andreoli, C. Carini, E. Bartoloni-Bocci, R. Gerli, C.B. Chighizola, M. Gerosa, P.L. Meroni, L. Sinigaglia, P. Conigliaro, R. Perricone, A. Corrado, F. Cantatore, S. D’Angelo, M. Favaro, M. Larosa, A. Doria, A. Ruffatti, E. Generali, C. Selmi, M. Meroni, M. Cutolo, M. Padovan, M. Govoni, G. Pazzola, C. Salvarani, S. Peccatori, G. Paolazzi, I. Prevete, G.D. Sebastiani, G. Minisola, A. Brucato, V. Ramoni, R. Caporali, C. Montecucco, C. Tani, V. Signorini, M. Mosca, M. Trevisani, N. Malavolta, M. Vadacca, A. Afeltra, E. Vivaldelli, A. Maier, E. Visalli, R. Foti, L. Zuliani, A. Gabrielli, C. Campochiaro, E. Baldissera, M.G. Sabbadini, N. Romeo, A. Tincani
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatic Diseases (RD) frequently affect women during reproductive age, therefore counselling on family planning is crucial for their quality of life. Children's outcome is a major topic, but no large studies are available. <h3>Objectives</h3> To assess the long-term health conditions of children born to women with RD in a large multicentre cohort. <h3>Methods</h3> 24 Rheumatology Centres distributed the questionnaire (65 multiple-choice and 12 open-answer questions) to consecutive patients (18–55 years) in September 2015. Data were analysed dividing children upon maternal diagnosis: Chronic Arthritides (CA) and Connective Tissue Diseases (CTD). <h3>Results</h3> Data were collected for 320 children (166 males, 52%) born to 184 mothers (63 CA and 121 CTD). At the time of interview, children had a mean age of 17.1±9.6 years. Preterm delivery (&lt;37 w) was observed in 72 cases (22.5%), including 13 (4%)&lt;34 w. Data on autoimmune/inflammatory disease (AIID) and/or neurodevelopmental disorders (ND)/learning disabilities (LD) is reported in table 1. 12 children (3.7%) had a diagnosis of AIID, mostly coeliac disease (8/12, 67%)and 11 children (3.4%) of a ND and/or LD by a Paediatric Neuropsychiatrist. To rule out the possible effects of <i>in utero</i> exposure to maternal autoantibodies and/or anti-rheumatic drugs in the pathogenesis of ND, these data were retrieved for 280 children (88%) and a comparison was performed between 11 affected and 269 not-affected children (table 2). <h3>Conclusions</h3> In this long-term follow-up of children born to mothers with RD in this large, multicenter study of randomly interviewed women each AIID did not display a significantly increased frequency as compared to the literature; only coeliac showed a mild increased frequency. Children with LD had a tendency to cluster in the group of mothers with CTD, especially after maternal diagnosis (4/63, 6.3%), with a higher frequency as compared to general paediatric population. No significant relationships between ND/LD and prematurity, intrauterine drug exposure or maternal autoantibodies were identified. <h3>Acknowledgements</h3> Statistical analysis supported by an unrestricted grant by UCB Pharma. The authors wish to thank Patients Associations and Participants to the survey. <h3>Disclosure of Interest</h3> None declared