tbuckley/cabot-search huggingface dataset:
Evaluation de la surveillance de l’infection à ménincocoques en Europe
Authors: C Trotter, S Samuelsson, A Perrocheau, S de Greeff, H de Melker, S Heuberger, M Ramsay
Journal: Eurosurveillance (2005)

Dans la plupart des pays, la surveillance de l’infection a meningocoques est base sur une combinaison de systeme de declaration obligatoire et de notification par les laboratoires, les deux systemes etant consideres comme sous-estimant le poids de la maladie. L’incidence de l’infection a meningocoques varie selon les pays d’Europe, et en depit des nombreuses causes a l’origine de cette variation, il est important de mesurer le degre de sous-estimation afin de valider les comparaisons internationales. Nous avons realise une revue de la litterature sur l’evaluation de l’infection a meningocoques en Europe et sur les methodes disponibles pour estimer le degre de sous-declaration. Il en ressort que la sensibilite des systemes de surveillance varie entre les pays et avec le temps, l’ecart estime variant de 40 a 96%. Nous avons identifie cinq methodes valable pour mener des etudes d’evaluation, depuis les simples enquetes comparatives jusqu’a des techniques plus sophistiquees telles que la capture-recapture et les analyses de regression. Ces etudes peuvent etre utilisees pour identifier la faiblesse et les biais des donnees de surveillance, et permet d’ameliorer ces systemes. Ces resultats sont pertinents pour la surveillance d’autres maladies infectieuses, et en particulier celle de moindre mortalite et de plus faible impact publique que l’infection a meningocoque, pour lesquelles une evaluation pourrait etre utile.
Dose, Content, and Mediators of Family-Based Treatment for Childhood Obesity
Authors: Denise E. Wilfley, Brian E. Saelens, Richard I. Stein, John R. Best, Rachel P. Kolko, Kenneth B. Schechtman, Michael Wallendorf, R. Robinson Welch, Michael G. Perri, Leonard H. Epstein
Journal: JAMA Pediatrics (2017)

Elucidation of optimal dosing and treatment content is critical for health care providers, payers, and policy makers, as well as mechanisms of change to inform intervention delivery and training initiatives for childhood obesity.
Arid1a regulates response to anti-angiogenic therapy in advanced hepatocellular carcinoma
Authors: Chaobo Hu, Weiping Li, Feng Tian, Kai Jiang, Xiaoting Liu, Jin Cen, Qiang He, Zhixin Qiu, Yvonne Kienast, Zhong Wang, Haibin Zhang, Yuan Ji, Junhao Hu, Lijian Hui
Journal: Journal of Hepatology (2017)
Long-Term and Short-Term Antidepressant Use in General Practice: Data from a Large Cohort in the Netherlands
Authors: Klaas M. Huijbregts, AdriaanW. Hoogendoorn, Paulien Slottje, Anton J.L.M. van Balkom, Neeltje M. Batelaan
Journal: Psychotherapy and Psychosomatics (2017)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Antidepressant use is highly prevalent. Research has mainly focused on efficacy during short periods of use for depression and anxiety. There is a relative paucity of data regarding the frequency of long-term use. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; To determine the prevalence and possible increase of long-term use of antidepressants over recent years, we analyzed routine general practice care data in a large cohort of patients (&lt;i&gt;n&lt;/i&gt; = 156,620) in and around Amsterdam, The Netherlands. Additionally, predictors of long-term use were studied. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Prevalence of long-term use of antidepressants is substantial, and such use appears to be increasing: 30.3% of use was long-term over the period 1995-2005 compared to 43.7% for the period 2005-2015. Higher age, a registered diagnosis of anxiety or depression, and the use of SSRIs or SNRIs were associated with long-term use in multivariate analysis. In addition, specific antidepressants were differentially associated with long-term use. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Long-term antidepressant use is substantial and appears to be on the rise. Awareness of this phenomenon should be increased, such use should be prevented when possible, and reasons for long-term use need to be examined.
Six ans de surveillance des hépatites A et B en médecine générale, en France
Authors: A Flahault, P Maison, N Farran, V Massari
Journal: Eurosurveillance (1997)

Le reseau  Sentinelles  francais est compose de medecins generalistes qui enregistrent sur une base continue les cas concernant sept pathologies transmissibles (les syndromes grippaux, la diarrhee severe, la varicelle, les oreillons, la rougeole, l'uretrite, et les hepatites aigues presumees virales) et les prescriptions de serologie pour le VIH. Ce systeme de surveillance permet d'evaluer en continu l'incidence des infections par les virus A et B de l'hepatite (VHA et VHB) sur le territoire metropolitain francais.
Vigilancia de la nueva variante de la enfermedad de Creutzfeldt-Jakob en el Reino Unido
Authors: H J T Ward
Journal: Eurosurveillance (2000)

A finales de mayo de 2000, en el Reino Unido habia 54 casos confirmados y 13 casos probables de la nueva variante de la enfermedad de Creutzfeldt-Jakob (nvECJ) registrados por la Unidad Nacional para la Vigilancia de ECJ, creada en 1990. Todos los casos confirmados, con datos disponibles, son homocigoticos para metionina en el codon 129 del gen de la proteina prionica (PrP). Ademas de la labor de vigilancia en todo el pais, esta unidad colabora en proyectos financiados por la Union Europea, como el EUROCJD y el NEUROCJD, que tienen como objetivo efectuar una comparacion de datos procedentes de distintos paises que ayude a identificar nuevos factores de riesgo.
Associations of Endogenous Estradiol and Testosterone Levels With Plaque Composition and Risk of Stroke in Subjects With Carotid Atherosclerosis
Authors: Marija Glisic, Blerim Mujaj, Oscar L. Rueda-Ochoa, Eralda Asllanaj, Joop S.E. Laven, Maryam Kavousi, M. Kamran Ikram, Meike W. Vernooij, M. Arfan Ikram, Oscar H. Franco, Daniel Bos, Taulant Muka
Journal: Circulation Research (2017)

Sex steroids may play a role in plaque composition and in stroke incidence.To study the associations of endogenous estradiol and testosterone with carotid plaque composition in elderly men and postmenopausal women with carotid atherosclerosis, as well as with risk of stroke in this population.Data of 1023 postmenopausal women and 1124 men (≥45 years) with carotid atherosclerosis, from prospective population-based RS (Rotterdam Study), were available. At baseline, total estradiol (TE) and total testosterone (TT) were measured. Carotid atherosclerosis was assessed by ultrasound, whereas plaque composition (presence of calcification, lipid core, and intraplaque hemorrhage) was assessed by magnetic resonance imaging. TE and TT were not associated with calcified carotid plaques in either sex. TE was associated with presence of lipid core in both sexes (in women odds ratio, 1.48 [95% confidence interval [CI], 1.02-2.15]; in men odds ratio, 1.23 [95% CI, 1.03-1.46]), whereas no association was found between TT and lipid core in either sex. Higher TE (odds ratio, 1.58 [95% CI, 1.03-2.40]) and lower TT (odds ratio, 0.82 [95% CI, 0.68-0.98]) were associated with intraplaque hemorrhage in women but not in men. In women, TE was associated with increased risk of stroke (hazard ratio, 1.98 [95% CI, 1.01-3.88]), whereas no association was found in men. TT was not associated with risk of stroke in either sex.TE was associated with presence of vulnerable carotid plaque as well as increased risk of stroke in women, whereas no consistent associations were found for TT in either sex.
TCT-18 Feasibility, safety and outcomes of chronic total occlusion revascularization in end-stage renal disease
Authors: Yasir Parviz, Matthew Finn, Nisha Jhalani, Bharath Rathakrishnan, Keyvan Karimi Galougahi, Gary Mintz, Akiko Maehara, Ajay Jayant Kirtane, Ori Ben-Yehuda, Gregg Stone, Mark Hardy, Sumit Mohan, Geoffery Dube, Russell Crew, Jai Radhakrishnan, David Cohen, Lloyd Ratner, Ali Akhund, Ming Liao, Martin Leon, Jeffrey Moses, Emmanouil Brilakis, Dimitri Karmpaliotis, Ziad Ali
Journal: Journal of the American College of Cardiology (2017)
TCT-640 24 Month Results From a First-In-Human Data on the Paclitaxel Drug-Coated Chocolate Coronary PTCA Balloon Catheters in De-Novo Coronary Lesions
Authors: Georgios Bouras, Alexandre Abizaid, Carlos Garcia - Lithgow, Ecaterina Cristea, Alexandra Lansky
Journal: Journal of the American College of Cardiology (2017)
Taxane Followed by Anthracycline or Vice Versa: Impact of Sequential Order on Breast Cancer Recurrence?—Reply
Authors: Heikki Joensuu, Henrik Lindman
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Vigilância sentinela de infecção por VIH em centros de teste do VIH, Espanha 1992-2002
Authors: A Barrasa, J Castilla, J del Romero, I Pueyo, C de Armas, J A Varela, J M Ureña, F J Bru, J R Ordoñana, L M Sáez de Vicuña
Journal: Eurosurveillance (2004)

A infeccao por VIH em Espanha foi monitorizada em individuos submetidos a analise voluntaria do VIH em dez clinicas sentinela entre 1992 e 2002. Foram apenas considerados para incluao os doentes de primeira vez, e o seu numero aumentou de 4426 em 1992 para 6649 em 2002. A maioria reconheceu o seu risco de exposicao como heterossexual. A proporcao de consumidores de drogas intravenosas diminuiu de 19% para 2% da populacao de estudo e a proporcao de trabalhadores do sexo feminino aumentou de 6% para 26%. O numero de doentes diagnosticados com infeccao por VIH diminuiu de 604 em 1992 para 153 em 2002 e a prevalencia de infeccao por VIH desceu de 13,6% para 2.3% no mesmo periodo. Em todas as categorias de exposicao de risco, foi observada uma diminuicao da prevalencia da infeccao por VIH, mais acentuada durante os primeiros anos e que estabilizou nos ultimos anos. Em 2002, a prevalencia mais elevada de infeccao por VIH foi registada em consumidores de drogas intravenosas (IDUs) (14,2%), homens homo/bissexuais (7,5%) e individuos com um parceiro heterossexual infectado pelo VIH (10,2%).
A Rare Variant (rs933717) at <i><scp>FBXO</scp>31‐<scp>MAP</scp>1<scp>LC</scp>3B</i> in Chinese Is Associated With Systemic Lupus Erythematosus
Authors: Yuan‐yuan Qi, Xu‐jie Zhou, Swapan K. Nath, Celi Sun, Yan‐na Wang, Ping Hou, Rong Mu, Chun Li, Jian‐ping Guo, Zhan‐guo Li, Geng Wang, Hu‐ji Xu, Yan‐jie Hao, Zhuo‐li Zhang, Wei‐hua Yue, Huoru Zhang, Ming‐hui Zhao, Hong Zhang
Journal: Arthritis & Rheumatology (2017)

Objective Recent evidence from genetic, cell biology, and animal model studies has suggested a pivotal role of autophagy in mediating systemic lupus erythematosus ( SLE ). However, the genetic basis has not yet been thoroughly examined. Therefore, the aim of the present study was to identify additional susceptibility variants in autophagy‐related genes along with their functional significance. Methods First, we performed a gene family–based genetic association analysis in SLE patients with the use of ImmunoChip arrays, and then we selected the most strongly associated polymorphisms for replication in additional cohorts. To identify regulatory clues, we analyzed publicly available blood expression quantitative trait locus data and Encyclopedia of DNA Elements data on transcription factor binding sites and cell type‐specific differential expression. Functional effects were tested by luciferase reporter assays, electrophoretic mobility shift assays, and differential gene expression assays. Results In 14,474 samples, we observed that the rare Chinese variant rs933717T was associated with susceptibility to SLE (0.11% in cases versus 0.87% in controls; P = 2.36 × 10 – 10 , odds ratio 0.13). The rs933717 risk allele C correlated with increased MAP 1 LC 3B expression; increased MAP 1 LC 3B messenger RNA was observed in SLE patients and in lupus‐prone mice. In reporter gene constructs, the risk allele increased luciferase activity up to 2.7‐3.8‐fold in both HEK 293T and Jurkat cell lines, and the binding of HEK 293T and Jurkat cell nuclear extracts to the risk allele was also increased. Conclusion We observed a likely genetic association between light chain 3B, a widely used marker for autophagy, and susceptibility to SLE .
Peculiar Growth Lesions in Frogs Induced by Irradiation of Sperm Cells With X-Rays
Authors: Paul S. Henshaw
Journal: JNCI Journal of the National Cancer Institute (1943)

Peculiar Growth Lesions in Frogs Induced by Irradiation of Sperm Cells With X-Rays Get access Paul S. Henshaw Paul S. Henshaw senior radiobiologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 3, Issue 4, February 1943, Pages 409–417, https://doi.org/10.1093/jnci/3.4.409 Published: 01 February 1943
Handling time varying confounding in observational research
Authors: Mohammad Ali Mansournia, Mahyar Etminan, Goodarz Danaei, Jay S Kaufman, Gary Collins
Journal: BMJ (2017)

Many exposures of epidemiological interest are time varying, and the values of potential confounders may change over time leading to time varying confounding. The aim of many longitudinal studies is to estimate the causal effect of a time varying exposure on an outcome that requires adjusting for time varying confounding. Time varying confounding affected by previous exposure often occurs in practice, but it is usually adjusted for by using conventional analytical methods such as time dependent Cox regression, random effects models, or generalised estimating equations, which are known to provide biased effect estimates in this setting. This article explains time varying confounding affected by previous exposure and outlines three causal methods proposed to appropriately adjust for this potential bias: inverse-probability-of-treatment weighting, the parametric G formula, and G estimation<i>.</i>
Stigma and silence are key barriers to dealing with addiction, Bill Clinton says
Authors: Bob Roehr
Journal: BMJ (2017)

The twinned bonds of stigma and silence must be broken if America has any hope of tackling the addiction crisis that is killing one person every four minutes, the former US president Bill Clinton said at the launch of a report into the opioid epidemic.1

Clinton spoke of five family friends who have lost children to the crisis, one of whom was working for Hillary Clinton when he died. Clinton was speaking on 30 October at a Johns Hopkins University forum where the report, by the university and the Clinton Foundation, …
TCT-734 Impact of Stent Length on 5-year Clinical Outcomes following Second-generation Drug-eluting Stents Implantation
Authors: Ahmed Mashaly, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Won Young Jang, Woo Hyeun Kim, Eun Jin Park, Ja Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2017)
Pattern of dose delay and dose reduction among cancer patients treated with chemotherapy.
Authors: Hairong Xu, Chun Chao, Lanfang Xu, Kimberly Cannavale, Olivia Sattiyapiwat, John Page, Roberto Rodriguez, Leila Family
Journal: Journal of Clinical Oncology (2015)

e20705 Background: Chemotherapy dose delay or dose reduction due to chemotherapy induced toxicity or other consideration of patient factors has been shown to be associated with worse patient outcomes. The current study describes the pattern of dose delay and dose reduction in a retrospective cohort of 3,955 cancer patients in Kaiser Permanente Southern California, a large managed care organization. Methods: We identified the first chemotherapy course from patients diagnosed with incident non-Hodgkin’s lymphoma (NHL), breast, lung, gastric, ovarian or colorectal cancers from Kaiser Permanente Southern California Health plan (2010-2012). For each regimen, we estimated the incidences of dose delay (> 3 day delay in a given cycle), and dose reduction (>15% decrease relative to standard dose in a given cycle). Incidence proportions of chemotherapy dose delay/reduction were estimated overall and by chemotherapy cycle. Results: See Table. Conclusions: The incidences of chemotherapy dose delays and dose reductions varied significantly across tumor types and regimens, and were increased with advanced stages. Future research should focus on understanding the causes of dose delay and reduction. Identifying opportunities for proactive management of these causes will help minimize the need for dose delay and dose reduction and maximize treatment benefit. Tumor type and regimen N of cycles Dose delay, % Dose reduction, % Overall 18312 13.0 16.4 Stage I 3353 9.8 15.7 II 6162 10.6 14.4 III 5290 15.0 16.3 IV 3507 17.1 20.9 Breast AC 236 11.9 9.3 AC →T (dose dense) 1069 15.0 5.8 TAC 735 7.6 11.7 TC 2812 5.3 11.7 TCH 1500 8.5 31.5 Lung CARBO+TAX 606 13.9 28.2 CARBO+VP16 269 20.8 21.9 Cisplatin (or carboplatin)+permetrexed 208 10.1 24.5 NHL CHOP/RCHOP 1753 10.6 10.0 RCVP/CVP 248 10.1 10.5 Colorectal CAPOX 712 15.7 25.8 FOLFOX 2391 17.0 16.1 Ovarian CARBO+TAX 931 18.8 33.6
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis
Authors: F Nanne Croles, Kazem Nasserinejad, Johannes J Duvekot, Marieke JHA Kruip, Karina Meijer, Frank WG Leebeek
Journal: BMJ (2017)

<b>Objective</b>&nbsp;To provide evidence to support updated guidelines for the management of pregnant women with hereditary thrombophilia in order to reduce the risk of a first venous thromboembolism (VTE) in pregnancy. <b>Design</b>&nbsp;Systematic review and bayesian meta-analysis. <b>Data sources</b>&nbsp;Embase, Medline, Web of Science, Cochrane Library, and Google Scholar from inception through 14 November 2016. <b>Review methods</b>&nbsp;Observational studies that reported on pregnancies without the use of anticoagulants and the outcome of first VTE for women with thrombophilia were eligible for inclusion. VTE was considered established if it was confirmed by objective means, or when the patient had received a full course of a full dose anticoagulant treatment without objective testing. <b>Results</b>&nbsp;36 studies were included in the meta-analysis. All thrombophilias increased the risk for pregnancy associated VTE (probabilities ≥91%). Regarding absolute risks of pregnancy associated VTE, high risk thrombophilias were antithrombin deficiency (antepartum: 7.3%, 95% credible interval 1.8% to 15.6%; post partum: 11.1%, 3.7% to 21.0%), protein C deficiency (antepartum: 3.2%, 0.6% to 8.2%; post partum: 5.4%, 0.9% to 13.8%), protein S deficiency (antepartum: 0.9%, 0.0% to 3.7%; post partum: 4.2%; 0.7% to 9.4%), and homozygous factor V Leiden (antepartum: 2.8%, 0.0% to 8.6%; post partum: 2.8%, 0.0% to 8.8%). Absolute combined antepartum and postpartum risks for women with heterozygous factor V Leiden, heterozygous prothrombin G20210A mutations, or compound heterozygous factor V Leiden and prothrombin G20210A mutations were all below 3%. <b>Conclusions</b>&nbsp;Women with antithrombin, protein C, or protein S deficiency or with homozygous factor V Leiden should be considered for antepartum or postpartum thrombosis prophylaxis, or both. Women with heterozygous factor V Leiden, heterozygous prothrombin G20210A mutation, or compound heterozygous factor V Leiden and prothrombin G20210A mutation should generally not be prescribed thrombosis prophylaxis on the basis of thrombophilia and family history alone. These data should be considered in future guidelines on pregnancy associated VTE risk.
PTH-139 Usage of transmural metal stents for endoscopic ultrasound guided drainage of pseudocysts may lead to lower reintervention rates
Authors: J Ramesh, R Saunders, J Evans, P Ghaneh, M Raraty, V Yip, R Barkatali, F Hughes, R McCready, S Cicconi, R Sutton, JP Neoptolemos, C Halloran
Journal: Gut (2017)

Introduction  Endoscopic ultrasound (EUS) guided drainage is now the first line treatment for drainage of symptomatic pancreatic pseudocysts. This study investigates the effects of metal vs. plastic transmural stents. The primary outcome measure was defined as rate of reintervention for pseudocyst following stent.  Method  A prospectively maintained database from 2011–2016 was analysed. Fluid collections were characterised by CT imaging and EUS. All patients were discussed at multidisciplinary meeting prior to intervention.  Results  74 patients with pseudocysts were included in this analysis. There was no significant difference in patient demographics or indication for intervention between the groups. Metal stents were placed in 38 (51%) patients. Three patients (8%) with metal stents required further intervention compared to 11 patients (31%) with plastic stents (p=0.037). Technical success was similar between groups; 100% for metal vs 97% for plastic stents. At 6 weeks following procedure, pseudocyst drainage was achieved in 33/35 patients using metal vs 27/36 of the plastic stent group (p=0.046). 25 patients with metal stents achieved pseudocyst drainage at 6 months vs 23 (p=0.25) who had plastic stents. Early adverse events were less common in the metal stent group (8%) vs 33% with plastic stents (p=0.009).  Conclusion  Use of metal transmural stents for drainage of pancreatic pseudocysts may reduce reintervention rates and causes fewer adverse events compared to plastic stents. Drainage with metal stents is most effective by 6 weeks, with little difference between metal vs. plastic stents by 6 months.  Disclosure of Interest  None Declared