tbuckley/cabot-search huggingface dataset:
Abstract P3-14-03: Does fat transfer increase the risk of breast cancer recurrence? A meta-analysis involving 2382 patients
Authors: U Wazir, HEH Chehade, H Headon, M Oteifa, A Kasem, K Mokbel
Journal: Cancer Research (2017)

Abstract Introduction: Lipofilling is an increasingly popular technique for breast reconstruction following both mastectomy and breast conserving surgery. However, concerns remain over its oncological safety and its effect on cancer recurrence. Methods: A systematic literature review and meta-analysis was carried out. Patients who had undergone mastectomy and patients who had undergone breast conserving surgery (BCS) were looked at separately in order to investigate whether the addition of lipofilling had a significant effect on locoregional recurrence rate. Results: Eleven studies were used in the analysis yielding a total of 2382 patients. For patients undergoing mastectomy (mean follow up = 36.2 months: range=12-90) or BCS (mean follow up = 30.2 months: range = 12-60) , the addition of lipofilling was not found to significantly affect the locoregional recurrence rate. Conclusion: This meta-nalysis demonstrates that lipofilling is an oncologically safe procedure to be incorporated into breast reconstruction following either mastectomy or BCS for breast cancer. However a careful oncological follow up is recommended. In the future, more adequately- powered controlled clinical trials are needed in order to fully understand long term outcomes after lipofilling. Citation Format: Wazir U, Chehade HEH, Headon H, Oteifa M, Kasem A, Mokbel K. Does fat transfer increase the risk of breast cancer recurrence? A meta-analysis involving 2382 patients [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P3-14-03.
First Results of a New PCR-Based Approach for a Sensitive and Quantitative Monitoring of BCR-ABL Kinase Domain Mutations in Patients with Chronic Myeloid Leukemia.
Authors: Oliver Pelz-Ackermann, Michael W. Deininger, Michael Cross, Ines Kovacs, Christine Guenther, Knuth Krohn, Song-Yau Wang, Haifa K. Al-Ali, Dietger W. Niederwieser, Thoralf Lange
Journal: Blood (2006)
Diffuse Large B-Cell Lymphoma (DLBCL) Patients with Composite Histology Have Improved Early Outcome Compared to De Novo DLBCL When Treated with R-CHOP
Authors: Matthew J. Maurer, Thomas E. Witzig, William R. Macon, Sergei I. Syrbu, James R. Cerhan, Cristine Allmer, Patrick B. Johnston, Brian K. Link, Thomas M. Habermann
Journal: Blood (2008)
NHS gets £100m budget “sticking plaster” to help manage emergency demand
Authors: Gareth Iacobucci
Journal: BMJ (2017)

The NHS in England will receive an extra £100m (€115m; $120m) in 2017‑18 to invest in triage by GPs and other measures to ease the flow of patients into hospital emergency departments, the chancellor of exchequer has announced.

Philip Hammond’s 2017 spring budget also committed £325m to fund capital investments in the NHS’s sustainability and transformation plans (STPs) and £2bn extra to help stabilise social care over the next three years, with £1bn of this available to social care in 2017-18.1

The Treasury said that its £100m investment in emergency departments was in recognition of the severe pressures faced this winter,2 and would enable hospital trusts to invest in measures such as onsite GP triage to help manage demand and ensure that patients were seen quickly in the appropriate setting.

In his budget speech to the House of Commons Hammond …
Myeloid Neoplasm Gene Somatic Mutations in Patients with Severe Aplastic Anemia Treated with Eltrombopag and Standard Immunosuppression
Authors: Danielle M. Townsley, James N. Cooper, Thomas Winkler, Phillip Scheinberg, Olga Rios, Barbara Weinstein, Janet Valdez, Jennifer Lotter, Marie J. Desierto, Maria del Pilar Fernandez Ibanez, Colin Wu, Cynthia E. Dunbar, Wanlong Ma, Maher Albitar, Neal S. Young
Journal: Blood (2016)
Enhanced Removal of Phenol With Lidocaine vs Alcohol
Authors: Damian Cordoba Diaz, Marta Elena Losa Iglesias, Manuel Cordoba Diaz, Ricardo Becerro de Bengoa Vallejo
Journal: JAMA Dermatology (2017)

or lidocaine, indicating these solutions do not neutralize the phenol but merely dilute it.Alcohol is not an optimal choice for intraoperative irrigation of a surgical wound, and the recovery of more phenol using lidocaine vs alcohol suggests that it could be an optimal choice to eliminate any residual phenol that could cause continued burning of the germinal nail matrix.Our findings may help standardize treatment of ingrown toenails and thereby improve outcomes; however, a full clinical study is warranted to confirm our in vitro results.
Management of Chronic Insomnia Disorder in Adults
Authors: Lisa Medalie, Adam S. Cifu
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tumor-associated macrophages: from basic research to clinical application
Authors: Li Yang, Yi Zhang
Journal: Journal of Hematology & Oncology (2017)

The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as "protumoral macrophages," contributing to disease progression. TAMs can promote initiation and metastasis of tumor cells, inhibit antitumor immune responses mediated by T cells, and stimulate tumor angiogenesis and subsequently tumor progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential biomarkers for diagnosis and prognosis of cancers, as well as therapeutic targets in these cases. In this review, we will discuss the origin, polarization, and role of TAMs in human malignant tumors, as well as how TAMs can be used as diagnostic and prognostic biomarkers and therapeutic targets of cancer in clinics.
Israeli Physician Salman Zarka, MD: Caring for Syrian Patients Is Our Duty
Authors: Jennifer Abbasi
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autologous Hematopoietic Cell Transplantation in Elderly Patients Aged 65 and Older: A Retrospective Analysis By the Complications and Quality of Life Working Party of the EBMT
Authors: Isabel Sánchez-Ortega, Grzegorz W. Basak, Eric Beohou, Steffie van der Werf, Myriam Labopin, Anja van Biezen, Nicolaus Kroeger, Silvia Montoto, Arnon Nagler, Peter Dreger, Hartmut Goldschmidt, Didier Blaise, Hermann Einsele, Jürgen Finke, Nigel H Russell, Mathias Haenel, Michael Potter, Denis Caillot, Hans-Juergen Salwender, Per T. Ljungman, Charles Craddock, Laurent Garderet, Anna Sureda, Mohamad Mohty, Tapani Ruutu, Rafael F. Duarte
Journal: Blood (2016)
Quantifying US Residency Competitiveness in Different Fields—Reply
Authors: David A. Faber, Shivam Joshi, Mark H. Ebell
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Corneal Models: Surface Topography and Mechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model (Adv. Healthcare Mater. 5/2017)
Authors: Wei Zhang, Jialin Chen, Ludvig J. Backman, Adam D. Malm, Patrik Danielson
Journal: Advanced Healthcare Materials (2017)

In article number 1601238, Patrik Danielson and co-workers create a novel biomimetic 3D corneal model by optimizing the surface topography and mechanical strain similar to the microenvironment of native cornea. Compared to traditional 2D culture conditions, this 3D culture model, in the form of a collagen-modified, silk fibroin-patterned construct subjected to 3% dome-shaped strain, further enhances the expression of keratocyte and ECM markers, and better maintains the keratocyte phenotype, alignment and fusiform cell shape.
Myocardial Fibrosis by Delayed Enhancement Cardiovascular Magnetic Resonance and HCV Infection In Thalassemia Major Patients
Authors: Alessia Pepe, Antonella Meloni, Zelia Borsellino, Maria Chiara Dell'Amico, Caterina Borgna-Pignatti, Aurelio Maggio, Vincenzo Positano, Eliana Cracolici, Massimo Lombardi, Marcello Capra
Journal: Blood (2010)
Inactivation of Tumor Necrosis Factor 3 Gene (TRAF3) Is Frequently Identified in Waldenström’s Macroglobulinemia Patients.
Authors: Esteban Braggio, Jonathan J. Keats, Scott Van Wier, Tammy Price-Troska, Kimberly Henderson, Marta Chesi, John Carpten, Leif P. Bergsagel, Rafael Fonseca
Journal: Blood (2007)
Abstract P4-13-01: Prospective association between breast cancer risk and an individual dietary index based on the British Food Standards Agency nutrient profiling system
Authors: M Deschasaux, C Julia, L Zelek, E Kesse-Guyot, V Gourlet, L Lécuyer, C Méjean, P Ducrot, S Peneau, P Latino-Martel, L Fézeu, P Fassier, S Hercberg, M Touvier
Journal: Cancer Research (2017)

Abstract Background: The Food Standards Agency Nutrient Profiling System (FSA-NPS) constitutes the basis for the Five-Colour Nutrition Label suggested in France to be put on the front-of-pack of food products. At the individual level, a dietary index (FSA-NPS DI) has been derived and validated and corresponds to a weighted mean of all FSA-NPS scores of foods usually consumed by the individual, reflecting the nutritional quality of his/her diet. Our aim was to investigate the association between the FSA-NPS DI and breast cancer risk in a large cohort. Methods: This prospective study included 46,864 women aged over 35y from the NutriNet-Santé cohort (2009-2015) who completed at least three 24h dietary records during the first 2y of follow-up (median follow-up: 4.0y). 555 incident breast cancers were diagnosed. FSA-NPS DI was computed for each subject using the following nutrient content for 100g of each foods and beverages consumed: energy, total sugar, saturated fatty acid, sodium, fruits and vegetables (%), fibres and proteins. Higher values of the FSA-NPS DI correspond to a lower nutritional quality of the diet. Associations were characterized by multivariate Cox proportional hazards models. Results: The FSA-NPS DI was directly associated with breast cancer risk (HR1-point increment=1.06 (1.02-1.11), P-trend=0.005; HRQ5vs.Q1=1.52 (1.11-2.08), P-trend=0.002). These associations were similar after the exclusion of cases diagnosed during the first year of follow-up. Conclusions: In this prospective study, a higher FSA-NPS individual score was associated with an increased breast cancer risk. These results suggested that unhealthy food choices may be associated with a 52% increase in breast cancer risk (FSA-NPS DI ≥7.7 (Q5) vs. &amp;lt;4.1 (Q1)), supporting the public health relevance of developing front-of-pack nutrition labels based on this score. Citation Format: Deschasaux M, Julia C, Zelek L, Kesse-Guyot E, Gourlet V, Lécuyer L, Méjean C, Ducrot P, Peneau S, Latino-Martel P, Fézeu L, Fassier P, Hercberg S, Touvier M. Prospective association between breast cancer risk and an individual dietary index based on the British Food Standards Agency nutrient profiling system [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P4-13-01.
PP06. HYPOMETHYLATION OF HEXOKINASE 2 IS A FREQUENT EVENT IN GLIOBLASTOMA MULTIFORME
Authors: Mr Daniel Blakeway, Dr Katherine Karakoula, Dr Mark Morris, Mr Lawrence Eagles, Dr Farjana Begam Rowther, Dr Anushree Singh, Mrs Kate Ashton, Prof Tim Dawson, Prof John Darling, Prof Tracy Warr
Journal: Neuro-Oncology (2017)

HK2 is highly expressed in several cancers including colon and breast and its role as the rate-limiting step of glycolysis may potentially contribute to tumour growth. Overexpression of HK2 has also been associated with drug resistant phenotypes. Inhibition of HK2 has increased the effectiveness of anticancer agents suggesting HK2 as both a potential genetic modifier and therapeutic target. There is evidence that HK2 is epigenetically silenced in normal tissue and that increased expression in tumours is due to hypomethylation. In this study, methylation status and expression levels of HK2 were determined in 36 glioblastoma multiforme (GBM) fresh frozen biopsies and 9 patient-derived GBM short-term cultures by methylation specific-PCR (MS-PCR) and RT-PCR respectively. More than 90% (n=33) of the GBM biopsies showed some hypomethylation of HK2, including 5 tumour samples that were completely hypomethylated. Total hypermethylation of HK2 was present in only 3 biopsy samples. There was good correlation between methylation status and level of expression; no mRNA transcripts were detected in tumours samples with complete HK2 methylation. There was also complete hypomethylation of HK2 in 4 (44%) of the short-term cultures and the remaining 5 cultures had only partial methlyation. Expression of HK2 was detected in all culture samples. This data demonstrates that hypomethylation of HK2 is a frequent event in GBM compared to normal brain. Furthermore, the high levels of HK2 expression detected in short-term cultures will enable future investigations of HK2 inhibitors as a therapeutic option in GBM.
Erratum: Imatinib Mesylate Resistance Through BCR-ABL Independence in Chronic Myelogenous Leukemia (Cancer Research (January 15, 2004) (672-677))
Authors: Nicholas J. Donato, Ji Y. Wu, Jonathan Stapley, Hui Lin, Ralph Arlinghaus, Bharat B. Aggarwal, Shishir Shishodia, Maher Albitar, Kimberly Hayes, Hagop Kantarjian, Moshe Talpaz
Journal: Cancer Research (2004)
Abstract P6-11-16: PYTHIA: A phase II study of palbociclib plus fulvestrant versus placebo plus fulvestrant for pretreated patients with ER+/HER2- metastatic breast cancer
Authors: D Zardavas, M Regan, R Maibach, B Ruepp, A Hiltbrunner, L Blacher, T Goulioti, R Gelber, P Flamen, M Piccart, L Malorni
Journal: Cancer Research (2017)

Abstract This abstract was not presented at the symposium.
Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats
Authors: Clark Zhang, Elizabeth A. Nance, Panagiotis Mastorakos, Jane Chisholm, Sneha Berry, Charles Eberhart, Betty Tyler, Henry Brem, Jung Soo Suk, Justin Hanes
Journal: Journal of Controlled Release (2017)
British Association of Dermatologists’ guidelines for the management of contact dermatitis 2017
Authors: G.A. Johnston, L.S. Exton, M.F. Mohd Mustapa, J.A. Slack, I.H. Coulson, J.S.C. English, J.F. Bourke, P.M. McHenry, K. Gibbon, D.A. Buckley, T.A. Leslie, E.C. Mallon, S. Wakelin, S. Ungureanu, R.Y.P. Hunasehally, M. Cork, J. Natkunarajah, F.S. Worsnop, N. Chiang, J. Donnelly, C. Saunders, A.G. Brain, LS Exton
Journal: British Journal of Dermatology (2017)
Abstract P6-01-14: Dissection of the Abl interactor 1 signaling in metastatic breast cancer cells
Authors: P Jiang, H Tang, H Hogan, S Tate, W Ryan, L Paul, X Liu, D Zonghan
Journal: Cancer Research (2017)

Abstract Abl interactor 1 (Abi1) is a key component of WAVE regulatory complex (WRC) that regulates actin cytoskeleton reorganization, membrane receptor signaling, and intracellular trafficking. Recent in vitro and in vivo studies as well as the studies of human patient samples suggest that Abi1 may play an important role in breast cancer (BC) metastasis. To determine if Abi1 is deregulated in metastatic breast cancer cells, we compared the expression of Abi1 in a panel of human breast cancer cell lines exhibiting distinct metastatic properties. In comparison with low-metastatic ER+/PR+ BC lines MCF-7 and T47D and a non-transforming mammary epithelial cell line MCF-10A, two ER-BC lines CN34 and MDA 231 and their sublines selected by high metastatic potential to bone (231Bo), brain (231Br and CN34Br), and lung (231LM2) show significantly reduced Abi1 protein levels, with greater reduction found in highly metastatic sublines. It is unlikely that the down-regulation of Abi1 expression in these metastatic BC cells occurs at mRNA level, because RT-PCR analysis shows no significant difference in Abi1 mRNA levels among the cells analyzed. Interestingly, despite a reduction in protein level, the tyrosine phosphorylation of Abi1 was increased in CN34, MDA231, and their metastatic sublines compared to low-metastatic BC cells. The tyrosine phosphorylation of Abi1 is stimulated by epidermal growth factor (EGF) in these cells and Abi1 is recruited to EGF receptor (EGFR) upon EGF stimulation. The deregulation of Abi1 in metastatic BC cells is mediated by Abl tyrosine kinases, as the inhibition of Abl family kinases by imatinib not only attenuates EGF-stimulated Abi1 tyrosine phosphorylation but also rescue the down-regulation of Abi1 protein in metastatic BC cells. These findings are consistent with a role of the EGFR-Abl-Abi1 signaling in BC metastasis. The studies suggest that this pathway may serve as a biomarker for diagnosis and/or prognosis of metastatic breast cancer. We have identified the tyrosine 213 in Abi1 as a major phosphorylation site stimulated by Abl kinases and have generated a unique conditional Abi1 depletion/re-expression system to dissect how the deregulation of the Abi1 signaling contributes to BC metastasis. Citation Format: Jiang P, Tang H, Hogan H, Tate S, Ryan W, Paul L, Liu X, Zonghan D. Dissection of the Abl interactor 1 signaling in metastatic breast cancer cells [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P6-01-14.
Segmental re-examination of the proximal colon and its impact on adenoma detection: Does seeing twice make nice?
Authors: Ian Gralnek
Journal: Endoscopy (2017)

Colonoscopy is the accepted gold standard for detecting colorectal adenomas and neoplasms [1]. Yet studies have consistently shown that a significant percentage of adenomas, especially small lesions, can be missed during colonoscopy [2]. This is problematic as missed adenomas can lead to interval colorectal cancers, especially in the right colon [3] [4] [5]. Thus, there has been an array of emerging technologies attempting to improve adenoma detection (or conversely reduce adenoma miss rates) [6]. Others have attempted to develop practical colonoscopic techniques or maneuvers that may be utilized by the colonoscopist to improve adenoma detection [7]. These techniques include prolonged colonoscope retroflexion in the right colon and extended withdrawal times. However, these maneuvers may not be consistently performed by the colonoscopist or may be done using a less-than-optimal technique as they require additional time, technical skill, and may confer a limited patient risk.
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade
Authors: Florence Allantaz, Damien Chaussabel, Dorothee Stichweh, Lynda Bennett, Windy Allman, Asuncion Mejias, Monica Ardura, Wendy Chung, Elisabeth Smith, Carol Wise, Karolina Palucka, Octavio Ramilo, Marilynn Punaro, Jacques Banchereau, Virginia Pascual
Journal: The Journal of Experimental Medicine (2009)