tbuckley/cabot-search huggingface dataset:
Reply to Morice and Hart: Increased Propensity for Pneumonia with Fluticasone in Chronic Obstructive Pulmonary Disease
Authors: David A. Lipson, Helen Barnacle, Ruby Birk, Noushin Brealey, Nicholas Locantore, David A. Lomas, Andrea Ludwig-Sengpiel, Rajat Mohindra, Maggie Tabberer, Chang-Qing Zhu, Steven J. Pascoe
Journal: American Journal of Respiratory and Critical Care Medicine (2017)
Evolution of the Surgical Technique to Improve Functional Outcomes in Robot-Assisted Laparoscopic Prostatectomy (RALP): A Single Centre Experience of Over 500 Cases
Authors: P. Gurung, S. Bhasin, S. Hussain, H. Sensi, Y. Prakashkumar, J. Boddy, P. Cooke
Journal: International Journal of Surgery (2017)
Transvaginal mesh failure: lessons for regulation of implantable devices
Authors: Carl Heneghan, Jeffrey K Aronson, Ben Goldacre, Kamal R Mahtani, Annette Plüddemann, Igho Onakpoya
Journal: BMJ (2017)

<b>Carl Heneghan and colleagues</b> describe how failings in the process for the marketing approval of implantable transvaginal mesh devices may have exposed women to avoidable harms and how to avoid their repetition
Serial FDG-PET/CT Imaging in the Management of Cardiac Sarcoidosis
Authors: William Bremer, Nadera J. Sweiss, Yang Lu
Journal: Clinical Nuclear Medicine (2017)

A 60-year-old woman with biopsy-proven cardiac sarcoidosis status post implantable cardioverter defibrillator placement presented with periodic dizziness and dyspnea on exertion. Myocardial perfusion scan demonstrated a moderate sized, fixed perfusion defect along the mid to proximal anteroseptal wall of the left ventricle, with better perfusion on stress images. FDG-PET/CT demonstrated corresponding focal FDG avidity of the mid to proximal anteroseptal wall, suggestive of active cardiac sarcoidosis. Because of severe side effects, mycophenolate mofetil was discontinued, and the patient received low-dose steroid therapy. At 7-month follow-up FDG PET/CT, there was increased FDG avidity in the same regions, indicating worsening cardiac sarcoidosis.
Cardiovascular Guideline Skepticism vs Lifestyle Realism?
Authors: Philip Greenland
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of Obesity in Patients with Multiple Myeloma Receiving High-Dose Melphalan Followed By Autologous Hematopoietic Cell Transplantation
Authors: Justina Ofori Frimpong, Rebecca Tombleson, Melissa Alsina, Jamie Shapiro, Jongphil Kim, Binglin Yue, Janelle Perkins, Taiga Nishihori
Journal: Blood (2016)
Abstract 08: Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas
Authors: Chao Lu, Simon Papillon-Cavanagh, Tenzin Gayden, Leonie G. Mikael, Denise Bechet, Christina Karamboulas, Laurie Ailles, Jason Karamchandani, Dylan M. Marchione, Benjamin A. Garcia, Ilan Weinreb, David Goldstein, Peter W. Lewis, Octavia-Maria Dancu, Sandeep Dhaliwal, William Stecho, Christopher J. Howlett, Joe S. Mymryk, John W. Barrett, Anthony C. Nichols, C David Allis, Jacek Majewski, Nada Jabado
Journal: Clinical Cancer Research (2017)

Abstract Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs) are deadly and common cancers. Recent genomic studies implicate multiple genetic pathways, including cell signaling, cell cycle and immune evasion, in their development. Here we analyze public data sets and uncover a previously unappreciated role of epigenome deregulation in the genesis of 13% of HPV-negative HNSCCs. Specifically, we identify novel recurrent mutations encoding p.Lys36Met (K36M) alterations in multiple H3 histone genes. We further validate the presence of these alterations in multiple independent HNSCC data sets and show that, along with previously described NSD1 mutations, they correspond to a specific DNA methylation cluster. The K36M substitution and NSD1 defects converge on altering methylation of histone H3 at K36 (H3K36), subsequently blocking cellular differentiation and promoting oncogenesis. Our data further indicate limited redundancy for NSD family members in HPV-negative HNSCCs and suggest a potential role for impaired H3K36 methylation in their development. Further investigation of drugs targeting chromatin regulators is warranted in HPV-negative HNSCCs driven by aberrant H3K36 methylation. Citation Format: Chao Lu, Simon Papillon-Cavanagh, Tenzin Gayden, Leonie G. Mikael, Denise Bechet, Christina Karamboulas, Laurie Ailles, Jason Karamchandani, Dylan M. Marchione, Benjamin A. Garcia, Ilan Weinreb, David Goldstein, Peter W. Lewis, Octavia-Maria Dancu, Sandeep Dhaliwal, William Stecho, Christopher J. Howlett, Joe S. Mymryk, John W. Barrett, Anthony C. Nichols, C David Allis, Jacek Majewski, Nada Jabado. Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr 08.
Abstract 13031: Ultrasound Molecular Imaging of Inflammation in Mouse Abdominal Aorta With Modulated Acoustic Radiation Force
Authors: Shiying Wang, Elizabeth B Herbst, Sunil Unnikrishnan, Alexander L Klibanov, F W Mauldin, John A Hossack
Journal: Circulation (2016)

Introduction: Ultrasound molecular imaging has demonstrated the ability to detect the molecular signature of early vascular inflammation. Consequently, it may enable more timely detection of atherosclerosis. Unfortunately, existing methods face substantial challenges in large blood vessels. Recently, a new modulated acoustic radiation force (ARF)-based imaging method has demonstrated rapid and quantitative measurements of biomarkers in large vessels. Hypothesis: We hypothesized that a clinically translatable method could be tested pre-clinically for non-invasive rapid detection of vascular cell adhesion molecule (VCAM)-1 in the mouse abdominal aorta. Methods: C57BL/6 mice fed with a high-fat diet were used as a diet-induced obesity model (M DIO ). Normal mice were used as controls (M Normal ). Anti-VCAM-1 and isotype control antibodies were conjugated to microbubbles to form the VCAM-1 targeted (MB VCAM-1 ) and control (MB Control ) microbubbles, respectively. Constant infusions of microbubbles were performed, during imaging, for 180 s ( A ). A parameter, residual-to-saturation ratio (RSR), was extracted and used to assess VCAM-1 expression. Four groups of mice were studied (5 mice per group): M Normal + MB Control , M DIO + MB Control , M Normal + MB VCAM-1 , and M DIO + MB VCAM-1 . Results: RSR of the M DIO + MB VCAM-1 group was 56.0%, significantly higher ( p &lt; 0.0005) than that of any other group (-94.9% for M Normal + MB Control , -13.9% for M DIO + MB Control , and -37.4% for M Normal + MB VCAM-1 ) ( B ). Immunohistochemistry confirmed M Normal exhibited minimal VCAM-1 staining while M DIO exhibited VCAM-1 staining localized to the endothelium ( C ). Conclusions: In conclusion, a statistically significant assessment of VCAM-1 in mouse abdominal aorta was achieved using the modulated ARF-based method. This technique yields progress towards rapid targeted molecular imaging in large blood vessels, and thus has long-term potential for early diagnosis of atherosclerosis.
Isolation of a novel IgG from a patient with lung cancer using immunoassays and cloning.
Authors: Scott K. Dessain, Hossein Borghaei, Jiping Zhang, Paul Simon, Minzhou Huang, Huiwu Zhao, Rama Devudu Puligedda, Maureen E. Murphy
Journal: Journal of Clinical Oncology (2013)

e22163 Background: Cancer cells express novel antigens that are characteristic of the transformed state and may engender an immune response ( i.e., antibody production) in patients. These antibodies may identify novel immune targets for antibody-based immunotherapies and diagnostics. Furthermore, the presence of these auto-antibodies could be followed as biomarkers of therapeutic response or relapse. Previous studies of the antibody response to tumors have been hampered by inefficient methods of cloning the human antibodies in their native configurations. We collected blood samples from a group of lung cancer patients with diverse clinical and pathologic features and are characterizing the anti-tumor antibody response using a variety of whole-cell binding assays. Our approach also uses an optimized hybridoma method to clone tumor-specific IgG antibodies from primary memory B-cells. Methods: We obtained serum and peripheral blood mononuclear cell samples from 50 patients with advanced lung cancer. We characterized the immune response of these patients to tumor cell lines using fluorescence microscopy with the Operetta (Perkin Elmer) and by whole-cell ELISA. We performed a cell fusion using B-cells from one of the immunoreactive patients, screening the hybridomas for antibodies specific for binding in the whole cell ELISA. We characterized the antibody activity using flow cytometry and immunoblotting, and we identified the antigen using mass spectroscopy analysis of a gel-purified, immunoreactive band. We confirmed the identity of the antigen bound by immunoblotting to recombinant protein. Results: Human IgG antibodies immunoreactive with human cancer cell lines are prevalent in our panel of lung cancer patients. Using our hybridoma method, we isolated a human IgG that binds a tumor-specific surface antigen expressed in a variety of tumors, but only minimally expressed by normal cells. Conclusions: Novel IgG antibodies against specific tumor antigens can be isolated from lung cancer patients’ serum.Using our novel hybridoma method for cloning human antibodies, we have identified an antibody that binds a tumor-specific antigen. The study of these antibodies may lead to novel biomarkers for cancer diagnosis and therapy.
Objective Responses Achieved in Patients with MYC-Altered Relapsed/Refractory Diffuse Large B-Cell Lymphoma Treated with the Dual PI3K and HDAC Inhibitor CUDC-907
Authors: Daniel J. Landsburg, Rod Ramchandren, Yasuhiro Oki, John M. Pagel, P.J. Lugtenburg, Robert Gharavi, Anna Ma, Amir Hafeez, Stefan Klaus Barta
Journal: Blood (2017)
JAMA Network Articles of the Year
Authors: Jennifer Abbasi
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Vivo FRET Imaging to Predict the Risk Associated with Hepatic Accumulation of Squalene‐Based Prodrug Nanoparticles
Authors: Fanny Cayre, Simona Mura, Bohdan Andreiuk, Dunja Sobot, Sandrine Gouazou, Didier Desmaële, Andrey S. Klymchenko, Patrick Couvreur
Journal: Advanced Healthcare Materials (2017)

Abstract Förster resonance energy transfer (FRET) is used here for the first time to monitor the in vivo fate of nanoparticles made of the squalene‐gemcitabine prodrug and two novel derivatives of squalene with the cyanine dyes 5.5 and 7.5, which behave as efficient FRET pair in the NIR region. Following intravenous administration, nanoparticles initially accumulate in the liver, then they show loss of their integrity within 2 h and clearance of the squalene bioconjugates is observed within 24 h. Such awareness is a key prerequisite before introduction into clinical settings.
Biology and Management of Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma, and Malignant Peripheral Nerve Sheath Tumors: State of the Art and Perspectives
Authors: Brigitte C. Widemann, Antoine Italiano
Journal: Journal of Clinical Oncology (2017)

Undifferentiated pleomorphic sarcomas, myxofibrosarcomas, and malignant peripheral nerve sheath tumors are characterized by complex genomic characteristics and aggressive clinical behavior. Recent advances in the understanding of the pathogenesis of these tumors may allow for the development of more-effective innovative therapeutic strategies, including immunotherapies. This review describes the current knowledge of the epidemiology, clinical presentation, treatment, and pathogenesis of these tumors and highlights ongoing and future research.
T cell responses in patients with melanoma resistant to multiple immunotherapies
Authors: R. Andersen, T.H. Borch, A. Draghi, A. Gokuldass, M.A.H. Rana, M. Pedersen, M. Nielsen, P. Kongsted, J.W. Kjeldsen, M.C.W. Westergaard, L.R. Hölmich, H.W. Hendel, M.S. Larsen, Ö Met, I.M. Svane, M. Donia
Journal: Annals of Oncology (2017)
Abstract 17955: Hurricane Katrina and Acute Myocardial Infarction: Ten Years After the Storm
Authors: Hassan Baydoun, John Moscona, Patrick Ters, Ahmad Jabbar, Alaa Boulad, Indrajeet Mahata, Taraka Gadiraju, Muhammad Raja, Kapil Yadav, Holly Gonzales, Christopher Westley, Ryan Nelson, Diane Davis, Thomas Middour, Chase Cannon, Sudesh Srivastav, Anand Irimpen
Journal: Circulation (2016)

Introduction: We aimed to evaluate the incidence and contributing factors of acute myocardial infarction (AMI) in New Orleans ten years after Hurricane Katrina. Methods: This is a single-center, re...
Abstract 17857: Trial Duration And Relative Risk Of Clinical Worsening With Combination Therapy In Pah Patients: A Meta-analysis
Authors: Annie C. Lajoie, Gabriel Lauziere, Jean-Christophe Lega, Yves Lacasse, Sylvie Martin, Serge Simard, Sébastien Bonnet, Steeve Provencher
Journal: Circulation (2016)

Introduction: Most randomized controlled trials (RCT) report results as relative risk (RR). The number needed to treat (NTT) has been used alternatively to provide information on the risk reduction...
Combination of brain radiotherapy (RT) and immunotherapy (IT) in a single Institution cohort of patients (pts) with metastatic melanoma (MM)
Authors: G. Galli, S. Cavalieri, L. Di Guardo, C. Cimminiello, F. Corti, F. Nichetti, M. Garcia, S. Tana, C. Fallai, F. de Braud, M. Platania, M. Del Vecchio
Journal: Annals of Oncology (2017)
The Importance of Continued US Investment to Sustain Momentum Toward Global Health Security
Authors: Jennifer B. Nuzzo, Anita J. Cicero, Thomas V. Inglesby
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow
Authors: Matthew T. Stier, Jian Zhang, Kasia Goleniewska, Jacqueline Y. Cephus, Mark Rusznak, Lan Wu, Luc Van Kaer, Baohua Zhou, Dawn C. Newcomb, R. Stokes Peebles
Journal: The Journal of Experimental Medicine (2017)

Group 2 innate lymphoid cells (ILC2s) are effector cells within the mucosa and key participants in type 2 immune responses in the context of allergic inflammation and infection. ILC2s develop in the bone marrow from common lymphoid progenitor cells, but little is known about how ILC2s egress from the bone marrow for hematogenous trafficking. In this study, we identified a critical role for IL-33, a hallmark peripheral ILC2-activating cytokine, in promoting the egress of ILC2 lineage cells from the bone marrow. Mice lacking IL-33 signaling had normal development of ILC2s but retained significantly more ILC2 progenitors in the bone marrow via augmented expression of CXCR4. Intravenous injection of IL-33 or pulmonary fungal allergen challenge mobilized ILC2 progenitors to exit the bone marrow. Finally, IL-33 enhanced ILC2 trafficking to the lungs in a parabiosis mouse model of tissue disruption and repopulation. Collectively, these data demonstrate that IL-33 plays a critical role in promoting ILC2 egress from the bone marrow.
China's Silk Road and global health
Authors: Kun Tang, Zhihui Li, Wenkai Li, Lincoln Chen
Journal: The Lancet (2017)

In 2013, China proposed its Belt and Road Initiative to promote trade, infrastructure, and commercial associations with 65 countries in Asia, Africa, and Europe. This initiative contains important health components. Simultaneously, China launched an unprecedented overseas intervention against Ebola virus in west Africa, dispatching 1200 workers, including Chinese military personnel. The overseas development assistance provided by China has been increasing by 25% annually, reaching US$7 billion in 2013. Development assistance for health from China has particularly been used to develop infrastructure and provide medical supplies to Africa and Asia. China's contributions to multilateral organisations are increasing but are unlikely to bridge substantial gaps, if any, vacated by other donors; China is creating its own multilateral funds and banks and challenging the existing global architecture. These new investment vehicles are more aligned with the geography and type of support of the Belt and Road Initiative. Our analysis concludes that China's Belt and Road Initiative, Ebola response, development assistance for health, and new investment funds are complementary and reinforcing, with China shaping a unique global engagement impacting powerfully on the contours of global health.
Anti-aggregant tau mutant promotes neurogenesis
Authors: Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelkow
Journal: Molecular Neurodegeneration (2017)

The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss in the hippocampus whereas the anti-aggregant form has no deleterious effects. These two proteins differ mainly in their propensity to form ß structure and hence to aggregate.To elucidate the basis of these contrasting effects, we analyzed organotypic hippocampal slice cultures (OHSCs) from transgenic mice expressing the repeat domain (RD) of Tau with the anti-aggregant mutation (TauRDΔKPP) and compared them with slices containing pro-aggregant TauRDΔK. Transgene expression in the hippocampus was monitored via a sensitive bioluminescence reporter gene assay (luciferase).The expression of the anti-aggregant TauRDΔKPP leads to a larger volume of the hippocampus at a young age due to enhanced neurogenesis, resulting in an increase in neuronal number. There were no signs of activation of microglia and astrocytes, indicating the absence of an inflammatory reaction. Investigation of signaling pathways showed that Wnt-5a was strongly decreased whereas Wnt3 was increased. A pronounced increase in hippocampal stem cell proliferation (seen by BrdU) was observed as early as P8, in the CA regions where neurogenesis is normally not observed. The increase in neurons persisted up to 16 months of age.The data suggest that the expression of anti-aggregant TauRDΔKPP enhances hippocampal neurogenesis mediated by the canonical Wnt signaling pathway, without an inflammatory reaction. This study points to a role of tau in brain development and neurogenesis, in contrast to its detrimental role in neurodegeneration at later age.