tbuckley/cabot-search huggingface dataset:
Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant
Authors: Maria Salgado, Mi Kwon, Cristina Gálvez, Jon Badiola, Monique Nijhuis, Alessandra Bandera, Pascual Balsalobre, Pilar Miralles, Ismael Buño, Carolina Martinez-Laperche, Cristina Vilaplana, Manuel Jurado, Bonaventura Clotet, Annemarie Wensing, Javier Martinez-Picado, Jose Luis Diez-Martin
Journal: Annals of Internal Medicine (2018)

This article has been corrected. The original version (PDF) is appended to this article as a Supplement. Background: The multifactorial mechanisms associated with radical reductions in HIV-1 reservoirs after allogeneic hematopoietic stem cell transplant (allo-HSCT), including a case of HIV cure, are not fully understood. Objective: To investigate the mechanism of HIV-1 eradication associated with allo-HSCT. Design: Nested case series within the IciStem observational cohort. Setting: Multicenter European study. Participants: 6 HIV-infected, antiretroviral-treated participants who survived more than 2 years after allo-HSCT with CCR5 wild-type donor cells. Measurements: HIV DNA analysis, HIV RNA analysis, and quantitative viral outgrowth assay were performed in blood, and HIV DNA was also measured in lymph nodes, ilea, bone marrow, and cerebrospinal fluid. A humanized mouse model was used for in vivo detection of the replication-competent blood cell reservoir. HIV-specific antibodies were measured in plasma. Results: Analysis of the viral reservoir showed that 5 of 6 participants had full donor chimera in T cells within the first year after transplant, undetectable proviral HIV DNA in blood and tissue, and undetectable replication-competent virus (<0.006 infectious unit per million cells). The only participant with detectable virus received cord blood stem cells with an antithymocyte globulin–containing conditioning regimen, did not develop graft-versus-host disease, and had delayed complete standard chimerism in T cells (18 months) with mixed ultrasensitive chimera. Adoptive transfer of peripheral CD4+ T cells to immunosuppressed mice resulted in no viral rebound. HIV antibody levels decreased over time, with 1 case of seroreversion. Limitation: Few participants. Conclusion: Allo-HSCT resulted in a profound long-term reduction in the HIV reservoir. Such factors as stem cell source, conditioning, and a possible "graft-versus-HIV-reservoir" effect may have contributed. Understanding the mechanisms involved in HIV eradication after allo-HSCT can enable design of new curative strategies. Primary Funding Source: The Foundation for AIDS Research (amfAR).
Are adverse events (AEs) predictive of nivolumab activity? Data from the Italian expanded access program in metastatic renal cell carcinoma (mRCC)
Authors: E. Verzoni, G. Cartenì, E. Cortesi, F. Roila, M.G. Vitale, S. Buti, S. Pignata, F. Cognetti, L. Giustini, A. Damiani, D. Turci, C.N. Sternberg, C. Porta, F. Carrozza, G. Tortora, D. Tassinari, R. Passalacqua, A. Pazzola, G. Surico, G. Procopio
Journal: Annals of Oncology (2018)
Pertussis: An uncommon cause of microangiopathic hemolytic anemia in an infant
Authors: Angharad Pryce, Kirstin Lund, Mili Shah, Barbara J. Bain
Journal: American Journal of Hematology (2018)

His initial blood film showed lymphocytosis with some cleft nuclei, and unremarkable red cell morphology. However 6 days after admission he developed peri-orbital edema. Hb had fallen to 47 g/L and a repeat blood film showed marked red cell fragmentation, microspherocytes, and polychromasia (images). A direct antiglobulin test was negative. Bilirubin was elevated to 25 μmol/L (previously 8) and lactate dehydrogenase to 1400 U/L. Serum haptoglobin was undetectable. The platelet count remained within the normal range. Renal function remained normal throughout but proteinuria developed with a protein creatinine ratio of 2000 mg/mmol. The kidneys were structurally normal on ultrasonography. Serum ferritin was markedly raised at 2289 μg/L. A diagnosis of microangiopathic hemolytic anemia (MAHA) as a complication of pertussis was made. Other features to suggest a diagnosis of atypical hemolytic uremic syndrome were absent. Factor H and factor I were normal and subsequent genetic analysis did not detect mutations in genes encoding complement factors B, C3, H, H-related 5, I, or membrane cofactor protein. The infant made a full recovery with subsequent normalization of red cell indices and biochemical markers of hemolysis. There has been one previous report of MAHA complicating neonatal pertussis.1 In addition, there have been three reports of postpertussis hemolytic uremic syndrome, presenting following an initial period of respiratory infection with the classic triad of thrombocytopenia, MAHA, and acute kidney injury.2-4 Of these cases one had a normal factor H level but an abnormal factor H was found on Western blot analysis,2 whilst the other two did not have any abnormality identified in genes encoding C3, C4, factor H, or MCP3 or in ADAMTS13 or genes encoding factors B, H, and I.4 This case highlights the rare occurrence of MAHA following pertussis infection. Nothing to report.
Panchromoendoscopy Increases Detection of Polyps in Patients With Serrated Polyposis Syndrome
Authors: Jorge López-Vicente, Daniel Rodríguez-Alcalde, Luis Hernández, Fausto Riu Pons, Pablo Vega, Jesus Miguel Herrero Rivas, José Santiago García, Inmaculada Salces Franco, Marco Bustamante Balén, María López-Cerón, María Pellisé
Journal: Clinical Gastroenterology and Hepatology (2018)
Abstract 17810: Second Heart Field-Derived Smooth Muscle Cells Contribute to Angiotensin II-Induced Medial Thickness in the Ascending Aorta
Authors: Hisashi Sawada, Jessica J Moorleghen, Debra L Rateri, Mark W Majesky, Alan Daugherty
Journal: Circulation (2016)

Objective: Smooth muscle cells (SMCs) in the ascending aorta are reported to be derived from two different embryonic origins, cardiac neural crest (CNC) and second heart field (SHF). Although previous studies have shown the location of CNC- and SHF-derived SMCs in embryonic or juvenile aortas, the distribution of these cells in the adult aorta is still unclear. During angiotensin II (AngII)-infusion, medial pathologies are most pronounced on the adventitial aspect of the outer curvature in the ascending aorta. The aim of this study was to delineate the distribution of these cell origins in the adult ascending aorta and to investigate the influence of AngII on these lineages. Methods and Results: To map SMCs of CNC and SHF origin, ROSA26 lacZ mice were bred to transgenic mice containing Cre under control of a Wnt1 or Mef2c promotor, respectively. Whole aortas stained for β-galactosidase revealed differences in distribution of CNC and SHF-derived SMCs. The former SMCs were present from the aortic root and e...
Efficacy and safety of nivolumab for previously treated non-squamous cell carcinoma of the head and neck
Authors: Chiaki Suzuki, Naomi Kiyota, Yoshinori Imamura, Junpei Rikitake, Satoshi Sai, Shiro Kimbara, Yasuko Hyogo, Yoshiaki Nagatani, Yohei Funakoshi, Masanori Toyoda, Hironobu Minami
Journal: Annals of Oncology (2018)
The second recurrence of<i>Mycobacterium avium</i>complex lung disease after successful treatment for first recurrence
Authors: Byoung Soo Kwon, Tae Sun Shim, Kyung-Wook Jo
Journal: European Respiratory Journal (2018)

<b>Approximately 60% of patients who are successfully treated for their first recurrence of MAC lung disease eventually experience a second recurrence. Approximately half of the second recurrence patients require anti-MAC treatment.</b>http://ow.ly/3G2R30meImC
Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri
Authors: Tammi C. Vesth, Jane L. Nybo, Sebastian Theobald, Jens C. Frisvad, Thomas O. Larsen, Kristian F. Nielsen, Jakob B. Hoof, Julian Brandl, Asaf Salamov, Robert Riley, John M. Gladden, Pallavi Phatale, Morten T. Nielsen, Ellen K. Lyhne, Martin E. Kogle, Kimchi Strasser, Erin McDonnell, Kerrie Barry, Alicia Clum, Cindy Chen, Kurt LaButti, Sajeet Haridas, Matt Nolan, Laura Sandor, Alan Kuo, Anna Lipzen, Matthieu Hainaut, Elodie Drula, Adrian Tsang, Jon K. Magnuson, Bernard Henrissat, Ad Wiebenga, Blake A. Simmons, Miia R. Mäkelä, Ronald P. de Vries, Igor V. Grigoriev, Uffe H. Mortensen, Scott E. Baker, Mikael R. Andersen
Journal: Nature Genetics (2018)

Aspergillus section Nigri comprises filamentous fungi relevant to biomedicine, bioenergy, health, and biotechnology. To learn more about what genetically sets these species apart, as well as about potential applications in biotechnology and biomedicine, we sequenced 23 genomes de novo, forming a full genome compendium for the section (26 species), as well as 6 Aspergillus niger isolates. This allowed us to quantify both inter- and intraspecies genomic variation. We further predicted 17,903 carbohydrate-active enzymes and 2,717 secondary metabolite gene clusters, which we condensed into 455 distinct families corresponding to compound classes, 49% of which are only found in single species. We performed metabolomics and genetic engineering to correlate genotypes to phenotypes, as demonstrated for the metabolite aurasperone, and by heterologous transfer of citrate production to Aspergillus nidulans. Experimental and computational analyses showed that both secondary metabolism and regulation are key factors that are significant in the delineation of Aspergillus species.
Combustible and Electronic Tobacco and Marijuana Products in Hip-Hop Music Videos, 2013-2017
Authors: Kristin E. Knutzen, Meghan Bridgid Moran, Samir Soneji
Journal: JAMA Internal Medicine (2018)

Hip-hop is the leading music genre in the United States and its fan base includes a large proportion of adolescents and young adults of all racial and ethnic groups, particularly minorities. The appearance of combustible and electronic tobacco and marijuana products, especially brand placement and use by popular and influential artists, may increase the risk of tobacco and marijuana use and decrease perceptions of harm.To assess the prevalence of the appearance and use of combustible and electronic tobacco and marijuana products, including brand placement, in leading hip-hop songs.Analysis of top 50 songs from 2013 to 2017 of Billboard magazine's weekly Hot R&B/Hip-Hop Songs with videos that included the appearance or use of combustible tobacco and marijuana products (manufactured cigarettes, cigars, hookah or waterpipe, pipe, hand-rolled tobacco and marijuana products, marijuana buds); appearance of exhaled smoke or vapor without an identifiable source product; appearance or use of electronic tobacco and marijuana products (eg, electronic cigarettes); tobacco or marijuana brand placement; appearance or use of combustible and electronic tobacco and marijuana by main or featured artist. Data were collected from December 6, 2017, to June 4, 2018.Prevalence of (1) appearance or use of combustible tobacco and marijuana products, (2) appearance of smoke or vapor, (3) appearance or use of electronic tobacco and marijuana products, (4) tobacco or marijuana brand placement, and (5) appearance or use of combustible and electronic tobacco and marijuana by main or featured artist. Probability of appearance or use of combustible and electronic tobacco and marijuana products by quartile of viewership of videos.The proportion of leading hip-hop videos containing combustible use, electronic use, or smoke or vapor ranged from 40.2% (76 of 189) in 2015, to 50.7% (102 of 201) in 2016. For each year, the leading category of combustible use was hand-rolled products. The appearance of branded products increased from 0% in 2013 (0 of 82) to 9.9% in 2017 (10 of 101) for combustible products, and from 25.0% in 2013 (3 of 12) to 87.5% in 2017 (14 of 16) for electronic products. The prevalence of combustible or electronic product use or exhaled smoke or vapor increased by quartile of total number of views: 41.9% (8700 to 19 million views) among songs in the first quartile of viewership and 49.7% among songs in the fourth quartile of viewership (112 million to 4 billion views).Combustible and electronic tobacco and marijuana use frequently occurred in popular hip-hop music videos. The genre's broad appeal, use of branded products by influential artists, and rise of electronic product and marijuana use may contribute to a growing public health concern of tobacco and marijuana use.
A rapid diagnostic algorithm had &gt; 98% sensitivity and specificity for detecting active pulmonary tuberculosis
Authors: Aaron E. Glatt
Journal: Annals of Internal Medicine (2018)

ACP Journal Club16 October 2018A rapid diagnostic algorithm had > 98% sensitivity and specificity for detecting active pulmonary tuberculosisAaron E. Glatt, MD, FACP, FIDSA, FSHEAAaron E. Glatt, MD, FACP, FIDSA, FSHEASouth Nassau Communities Hospital, Oceanside, New York, USA (A.E.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2018-169-8-046 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationJafari C, Olaru ID, Daduna F, et al. Rapid diagnosis of pulmonary tuberculosis by combined molecular and immunological methods. Eur Respir J. 2018;51:1702189. https://pubmed.ncbi.nlm.nih.gov/29599184Clinical Impact RatingsGIM/FP/GP: Infectious Disease: Pulmonology: References1 Chaisson LH, Duong D, Cattamanchi A, et al. Association of rapid molecular testing with duration of respiratory isolation for patients with possible tuberculosis in a US hospital. JAMA Intern Med. 2018. [Epub ahead of print]. [PMID: 30178007] Google Scholar2 Dheda K, van Zyl-Smit RN, Meldau R, et al. Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis. Thorax. 2009;64:847-53. [PMID: 19592392] Google Scholar3 Khonga M, Nicol MP. Xpert MTB/RIF Ultra: a gamechanger for tuberculous meningitis? Lancet Infect Dis. 2018;18:6-8. [PMID: 28919337] Google Scholar Author, Article, and Disclosure InformationAffiliations: South Nassau Communities Hospital, Oceanside, New York, USA (A.E.G.)This article was published at Annals.org on 2 October 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 October 2018Volume 169, Issue 8Page: JC46KeywordsAlgorithmsBronchoalveolar lavageBronchoscopyHIVMicroscopyNucleic acidsSpecificitySputumThoraxWeight loss ePublished: 16 October 2018 Issue Published: 16 October 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease
Authors: Silke Nuber, Molly Rajsombath, Georgia Minakaki, Jürgen Winkler, Christian P. Müller, Maria Ericsson, Barbara Caldarone, Ulf Dettmer, Dennis J. Selkoe
Journal: Neuron (2018)
Phase II study of paclitaxel and TAK-228 in metastatic urothelial carcinoma and the impact of PI3K-mTOR pathway genomic alterations
Authors: A. Rodríguez-Vida, J.L. Pérez-Gracia, A. Taus, T. Bonfill, F.J. Vázquez-Mazón, S. Galtes, B. Pons, L. Cano, S. Macia, P. Maroto, J. Bellmunt
Journal: Annals of Oncology (2018)
Progression of disease within 2 years (POD24) is a clinically significant endpoint to identify follicular lymphoma patients with high risk of death
Authors: C. Sortais, A. Lok, T. Gastinne, B. Mahé, V. Dubruille, N. Blin, S. Howlett, A. Tabah, P. Arnaud, A. Moreau, P. Moreau, C. Leux, S. Le Gouill
Journal: Annals of Oncology (2018)
GW29-e1611 Metformin Mediate both Remodeling of Gap Junction and Susceptibility of Atrial Fibrillation via AMPK/mTOR Signaling Way
Authors: Jiayi Li, Biao Li, Fan Bai, Jie Qiu, Jin Xie, Fen Qin, Qiming Liu
Journal: Journal of the American College of Cardiology (2018)
Deletion of <i>Atm</i> in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma
Authors: Jordan A. Torok, Patrick Oh, Katherine D. Castle, Michael Reinsvold, Yan Ma, Lixia Luo, Chang-Lung Lee, David G. Kirsch
Journal: Cancer Research (2018)

Stereotactic body radiotherapy is utilized to treat lung cancer. The mechanism of tumor response to high-dose radiotherapy (HDRT) is controversial, with competing hypotheses of increased direct tumor cell killing versus indirect effects on stroma including endothelial cells. Here we used dual recombinase technology in a primary murine lung cancer model to test whether tumor cells or endothelial cells are critical HDRT targets. Lenti-Cre deleted one or two copies of ataxia-telangiectasia mutated gene (
Neoadjuvant chemotherapy and radical surgery versus chemorradiation for stage IB2, IIA2 e IIB cervical cancer: A randomized controlled trial
Authors: P.T.F. Reis Filho, J.M. Andrade, M.P. Batista, C.B. Sousa, T.H.G.F. Oliveira, G.V. Arruda, T.M.G. Oliveira, F. Gabrielli, M.L.N.D. Genta, A.M. Poveda, M.D.P. Estevez Diz, F.J. Candido Dos Reis
Journal: Annals of Oncology (2018)
2008–2018: a decade of recommendations for systemic lupus erythematosus
Authors: Dimitrios T Boumpas, George K Bertsias, Antonis Fanouriakis
Journal: Annals of the Rheumatic Diseases (2018)

Recommendations represent a popular way of integrating evidence-based medicine to clinical practice. These systematically developed statements can assist practitioner and patient decisions about appropriate healthcare, facilitate teaching of students and physicians, and educate patients. In 2008, the first European League Against Rheumatism (EULAR) recommendations for the management of general systemic lupus erythematosus (SLE) were published in the Annals of the Rheumatic Diseases (ARD).1 These were based on a combination of evidence and expert opinion, and followed the standard EULAR operating procedures. The effort involved experts on SLE, skilled methodologists and meticulous fellows who undertook an exhaustive systematic literature research (SLR). In this EULAR-endorsed project, a panel of European lupus experts was first updated on current literature and issues on SLE, and then developed and voted on the questions to be included in the SLR in an open and rigorous process. During the second phase, the results of the SLR were presented to the panel which then formulated, graded and voted on the recommendations. Recommendations covered the diagnosis, monitoring and management of general SLE with a few statements on neuropsychiatric and renal disease. Other EULAR panels also prepared recommendations for clinical trials in SLE,2 3 as well as more specific recommendations on …
Abstract 17466: Percutaneous Ventricular Assist Devices versus Intra-Aortic Balloon Pump in Cardiogenic Shock of Non-Ischemic Etiology
Authors: Gbolahan O Ogunbayo, Le Dung Ha, Odunayo Olorunfemi, Ayman Elbadawi, Deola Saheed, Andrew R Kolodziej, Adrian W Messerli, Maya E Guglin
Journal: Circulation (2017)

Introduction: In patients with cardiogenic shock due to acute myocardial infarction (AMI), percutaneous ventricular assist devices (PVADs) improve hemodynamic parameters, but do not offer mortality...
BP:血清抗 BP180 IgG 水平、死亡率和卡式评分
Authors: M.M. Holtsche, S. Goletz, N. van Beek, D. Zillikens, S. Benoit, K. Harman, S. Walton, J. English, M. Sticherling, A. Chapman, N.J. Levell, R. Groves, H.C. Williams, I.R. K€onig, E. Schmidt
Journal: British Journal of Dermatology (2018)

大疱性类天疱疮 (BP) 是一种罕见的慢性皮肤病, 主要在老年患者中引起水疱和严重瘙痒。它是一种自身免疫性皮肤病, 身体自身的免疫系统会针对皮肤结构发起攻击。其会产生称为自身抗体的特定蛋白质并导致炎症。德国每百万人中约有 259 人会受到该病影响。在最近发表的一项临床试验中,在英国和德国的 253 名 BP 患者中比较了两种不同的 BP 治疗方法。这项额外的研究,同样来自德国和英国,旨在探索这些患者的血液中是否有任何标记物告诉我们疾病的进程。因此,作者研究了参加一项试验的 143 名患者的血液,这项试验名为 BLISTER 试验。通过几项测试以检查这些患者血液中自身抗体的含量。然后将结果与基本参数相关联,基本参数包括年龄、一般状况、水疱数、副作用和死亡率。该研究显示, 一般状况较差的患者两种特异性自身抗体水平均较高,从而导致了该疾病。在入组研究的一年内死亡的患者具有更高含量的特异性自身抗体之一。其他特异性自身抗体的存在在老年患者中更为常见。总之, 分析自身抗体谱不仅有助于诊断, 还可能有助于预测疾病的进程。
GW29-e0480 Data-driven cluster analysis of hypertension and their association with cardiovascular outcomes and treatment effects: Systolic Blood Pressure Intervention Trial (SPRINT)
Authors: Xiaodong Zhuang, Lizhen Liao, Zhiqiang Nie, Daya Yang, Shaozhao Zhang, Huimin Zhou, Xiuting Sun, Xiangbin Zhong, Zhimin Du, Xinxue Liao
Journal: Journal of the American College of Cardiology (2018)
A phase II clinical investigation of BPM31510-IV (ubidecarenone) in patients with advanced pancreatic cancer
Authors: A.A. Niewiarowska, D.M. Lucius, R. Sarangarajan, N.R. Narain, R. Ramanathan, P. Ritch, J. Strauss, M. Kundranda, D. Propper
Journal: Annals of Oncology (2018)
Association of CD4+ Radiation-Induced Lymphocyte Apoptosis with Fibrosis and Telangiectasia after Radiotherapy in 272 Breast Cancer Patients with &amp;gt;10-Year Follow-up
Authors: Marlon R. Veldwijk, Petra Seibold, Akke Botma, Irmgard Helmbold, Elena Sperk, Frank A. Giordano, Nicole Gürth, Anne Kirchner, Sabine Behrens, Frederik Wenz, Jenny Chang-Claude, Carsten Herskind
Journal: Clinical Cancer Research (2018)

Radiation-induced lymphocyte apoptosis (RILA) has been suggested as a predictive assay for adverse late reactions after radiotherapy. Thus, low RILA values of T-lymphocyte subpopulations have been associated with increased risk for various endpoints at 2 to 3 years of follow-up. The purpose was to test if such associations persist for specific endpoints (subcutaneous fibrosis, telangiectasia) in breast cancer patients with at least 10 years of follow-up.Experimental Design: Two hundred and seventy-two female patients who had received breast-conserving therapy within the German ISE study were included (median follow-up: 11.6 years). Radiotherapy-induced side effects were scored according to the Late Effects in Normal Tissues-Subjective, Objective, Management, and Analytic (LENT-SOMA) classification system. RILA in the CD4+, CD8+, and natural killer (NK) subpopulations from peripheral blood was analyzed by flow cytometry. Multivariate predictive modeling was performed including relevant clinical risk factors.Low CD4+ RILA was associated with increased risk for both fibrosis (P = 0.011) and telangiectasia (P < 0.001). For fibrosis, the association was stronger outside the surgical area (Fibout; P = 0.004) than within (Fibin; P = 0.17). Predictive multivariate modeling including clinical risk factors yielded OR of 3.48 (95% confidence interval, 1.84-6.58) for any fibrosis and 8.60 (2.71-27.3) for telangiectasia. Addition of CD4+ RILA to the clinical variables improved discrimination (c statistics) from 0.62 to 0.68 for any fibrosis, 0.62 to 0.66 for Fibin, 0.61 to 0.69 for Fibout, and from 0.65 to 0.76 for telangiectasia. CD8+ and NK RILA were not significantly associated with radiotherapy-related late reactions.The results provide first evidence that low CD4+ RILA is associated with increased subcutaneous fibrosis and telangiectasia even after 10 years. This supports the potential usefulness for predicting individual clinical risk.
Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency
Authors: Jan Dudeck, Julia Froebel, Johanna Kotrba, Christian H.K. Lehmann, Diana Dudziak, Stephan Speier, Sergei A. Nedospasov, Burkhart Schraven, Anne Dudeck
Journal: Journal of Allergy and Clinical Immunology (2018)