tbuckley/cabot-search huggingface dataset:
Abstract P237: Moderate and Heavy Alcohol Consumption Are Associated With Decreased Systolic Function After 8 Years of Follow-up
Authors: Hanne Van Ballegooijen, Petra J Elders, Coen D Stehouwer, Jacqueline M Dekker, Joline Beulens
Journal: Circulation (2018)

Introduction: Excessive alcohol consumption is an important risk factors for cardiovascular disease, however, the underlying mechanisms are not well understood. Hypothesis: We assessed the hypothesis whether alcohol consumption is prospectively associated with unfavorable measures of cardiac structure and function. Methods: We used data from the Hoorn Study, a population-based, prospective cohort study. Data on self-reported alcohol consumption were collected with a validated food frequency questionnaire in 2000/2001(baseline for the current analyses). Echocardiography was performed in 2000/2001 in 582 participants and in 2007/2009 in 339 participants. Participants were classified into 5 categories based on self-reported alcohol consumption (glasses per week): 0 (non-drinkers), 0- 3 (light-drinkers), ≥3-7 (light to moderate drinkers), ≥7-14 (moderate drinkers) and ≥14 (heavy drinkers). Light drinking was considered the reference group. We studied the association of alcohol consumption with echocardiographic measures after 8 years of follow-up using linear regression analyses, adjusting for potential confounders. Results: The mean age was 69.8±6.5 years and 50% was female. After 7.4±0.5 years follow-up, moderate and heavy alcohol consumption were associated with a decreased left ventricular ejection fraction of -5.1% (-8.7, -1.4) for moderate and -4.8% (-8.8, -0.8) for heavy drinkers (Table). Heavy drinking was also associated with a decrease in left atrial volume index: -3.9mL/m 2 (-7.6, -0.2). No longitudinal associations were found between alcohol consumption and left ventricular mass index. Conclusion: Both moderate and heavy drinking were associated with decreased systolic function after 8 years follow-up. The toxic effect of alcohol could lead to underfilling of the left atrium which could lead to lower systolic function. These findings may explain the increased cardiovascular risk among people with excessive alcohol use.
Nivolumab in patients with DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) metastatic colorectal cancer (mCRC): Long-term survival according to prior line of treatment from CheckMate-142.
Authors: Michael J. Overman, Francesca Bergamo, Raymond S. McDermott, Massimo Aglietta, Franklin Chen, Fabio Gelsomino, Mark Wong, Michael Morse, Eric Van Cutsem, Alain Hendlisz, Bart Neyns, Rebecca Anne Moss, Huanyu Zhao, Z. Alexander Cao, Shital Kamble, Scott Kopetz, Thierry Andre
Journal: Journal of Clinical Oncology (2018)

554 Background: Nivolumab (NIVO) provided durable responses (ORR, 32% per central assessment) and disease control (DCR, 64%) in pre-treated pts with dMMR/MSI-H mCRC (NCT02060188; Overman MJ et al Lancet Oncol 2017). NIVO was approved in the US for pts with dMMR/MSI-H mCRC who progress after standard chemotherapy (SC) with a fluoropyrimidine (F), oxaliplatin (Ox), and irinotecan (Iri). Here we present long-term survival and outcomes by prior chemotherapy with NIVO in CheckMate-142. Methods: Pts with dMMR/MSI-H mCRC received NIVO 3 mg/kg Q2W. The primary endpoint was ORR per RECIST 1.1. Other endpoints were DCR, DOR, PFS, OS, and safety/tolerability. Results: Of 74 pts evaluated, 53 had received F, Ox and Iri (group A); 21 pts had ≤ 2 SC regimens (group B). Median follow-up was 21 mo. Efficacy by central assessment is shown in the Table. In the 74 pts, ORR was 34%; CRs increased from 3% in prior database lock (DBL) to 9%. Numerically higher responses were noted in group B vs group A (Table). Grade 3–4 TRAEs were reported in 20% (all pts), 25% (group A), and 10% (group B) of pts. No treatment-related deaths were reported. Conclusions: NIVO continued to provide clinically meaningful durable responses and long-term overall survival in pts with dMMR/MSI-H mCRC. Of note, CR rate increased with longer follow-up. No new safety signals were reported with long-term follow-up. Enhanced responses in pts with ≤ 2 SC regimens support ongoing evaluation of NIVO combinations in first-line setting. Clinical trial information: NCT02060188. [Table: see text]
Optimal Management of Pancreatic Cysts - A Cost-Effectiveness Analysis
Authors: A Das, S Nagendra, A Chak
Journal: Endoscopy (2006)

The management of asymptomatic pancreatic cysts, increasingly identified as incidental findings on abdominal imaging tests is a dilemma. A small proportion of mucinous cysts may progress to invasive cancer and an aggressive strategy of surgical resection of all cysts is often pursued with the attendant risk of surgery. Objective: We performed a decision analysis comparing the cost-effectiveness of different strategies for managing solitary, asymptomatic pancreatic cysts. Methods: Incremental cost-effectiveness ratio (ICER) of three primary strategies were examined in a Markov model with a societal perspective. Strategy I was a wait and watch approach with follow-up MRI every 3 years. Development of specific alarm symptoms or imaging features suggesting malignant transformation during surveillance would trigger further evaluation with EUS-FNA and appropriate management, including resection. In Strategy II, an initial EUS-FNA was performed and patients with increased cyst fluid CEA or positive cytology underwent resection. A. Strategy III was surgical resection of all cysts without prior EUS evaluation. Results: In a 60 year old person Strategy I yielded highest quality adjusted life years (QALY) with an acceptable ICER (Table) in both the baseline and a second order Monte Carlo analysis. Strategy II dominated strategy III, and was both cheaper and yielded more QALYs. Test characteristics of EUS-FNA, surgical risk score and the annual mortality rate of malignant mucinous cystic neoplasm were the three important threshold variables that influenced the optimal strategy. Conclusion: A conservative strategy is generally more cost-effective than surgical resection in managing incidental asymptomatic pancreatic cysts. An initial EUS-FNA based strategy is favored in selecting patients who may benefit from resection.
Joint Conference of BASEM and BASES
Authors: J Arbuthnot, M Mcnicholas, H Dashti, G Stables, K O'rourke, S Mun, M Browne, J Sheehan, S Cusack, M Molloy, R Phillip, A Wills
Journal: British Journal of Sports Medicine (2003)

There is little information that the orthopaedic surgeon can provide for patients concerned about the effect of a total hip arthroplasty (THA) operation on their ability to continue playing golf and at what level they can hope to play.We present the results of a study into the effect of THA for osteoarthritis on the golfing habits and performance of 750 patients.We sent 750 patients a questionnaire, which enquired about their participation in golf before and after the operation.We received 698 replies, 66 of which were from golfers.Harris hip scores are prospectively acquired before surgery and at regular intervals afterwards for all patients undergoing hip arthroplasty at our centre.Comparisons of hip scores for golfers were consistently higher than for non-golfers at all intervals.There was no statistically significant difference in the number of games played, maximum shot distance, shot accuracy, handicap, or ability to walk around the course after the operation.We conclude that THA does not have a detrimental effect on golf participation or performance.
Closing the Sex Divide in the Emerging Field of Neurology
Authors: Frances E. Jensen
Journal: JAMA Neurology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
PROSPECTIVE COMPARATIVE STUDY OF “STYLET SLOW-PULL” VERSUS “NEGATIVE PRESSURE” SUCTION IN EUS-GUIDED FINE NEEDLE ASPIRATION OF PANCREATIC MASS
Authors: JM Lee, HS Lee, SJ Choi, G Min, W Kim, JM Lee, SH Kim, HS Choi, ES Kim, B Keum, YT Jeen, HJ Chun, CD Kim
Journal: Endoscopy (2018)

To investigate the usefulness of ‘stylet slow-pull’ method, compared with conventional ‘negative pressure’ suction in EUS-FNA for pancreatic mass.
Dissection sous-muqueuse endoscopique de lésions néoplasiques superficielles et de tumeurs carcinoïdes du rectum: expérience monocentrique
Authors: D Coumaros, N Tsesmeli, D Tzilves, N Yahagi
Journal: Endoscopy (2009)

Introduction: La dissection sous-muqueuse endoscopique (ESD) a été développée au Japon pour la résection en-bloc des néoplasies superficielles. Notre but est de présenter une expérience mono-centrique d'ESD de lésions néoplasiques superficielles et de carcinoïdes du rectum.
DOUBLE-BALLOON ENTEROSCOPY IS USEFUL AND EFFECTIVE FOR THE DIAGNOSIS, ASSESSMENT AND MANAGEMENT OF SMALL BOWEL NEUROENDOCRINE TUMOURS: CASE SERIES FROM A NATIONAL TERTIARY REFERRAL CENTRE
Authors: A Telese, A Murino, E Phillips, F Laskaratos, TV Luong, N Koukias, D Mandair, C Toumpanakis, ME Caplin, EJ Despott
Journal: Endoscopy (2018)

Although small bowel (SB) neuroendocrine tumours (SBNETs) often present as indolent lesions, late diagnosis may result in poor outcomes. Successful management is therefore dependent on early identification. Double-balloon enteroscopy (DBE) enables direct SB mucosal visualisation, sampling and endotherapy. Our aim was to evaluate the role of DBE for early diagnosis and management of SBNETs.
Evaluation de l'atteinte grêlique proximale de la maladie de Crohn par vidéocapsule endoscopique: étude prospective comparative avec l'entéroscanner et le transit du grèle
Authors: S Karoui, S Ouerdiane, K Nouira, L Kallel, M Serghini, N Ben Mustapha, S Matri, M Fekih, J Boubaker, E Menif, A Filali
Journal: Endoscopy (2009)

Introduction: La vidéocapsule endoscopique (VCE) est une nouvelle technique permettant l'exploration de l'ensemble de l'intestin grèle. La maladie de Crohn touche principalement l'iléon terminal, mais l'atteinte grêlique proximale est certainement sous estimée par les méthodes d'imagerie et d'endoscopie conventionnelles.
Gastric Heterotopia of the Rectum
Authors: Maria Antonietta Pistoia, Stefano Guadagni, Terenzio Ventura, Francesco Pistoia, Manlio Carboni
Journal: Endoscopy (1986)

See also: Heterotopic Gastric Mucosa in the RectumEndoscopy 1984; 16(05): 197-199DOI: 10.1055/s-2007-1013008
Safety and efficacy of a fixed combination of halobetasol and tazarotene in the treatment of moderate-to-severe plaque psoriasis: Results of 2 phase 3 randomized controlled trials
Authors: Linda Stein Gold, Mark G. Lebwohl, Jeffrey L. Sugarman, David M. Pariser, Tina Lin, Gina Martin, Radhakrishnan Pillai, Robert Israel, Tage Ramakrishna
Journal: Journal of the American Academy of Dermatology (2018)

BackgroundTopical corticosteroids are the mainstay of psoriasis treatment, with long-term safety considerations limiting their use. Combining them with tazarotene may optimize their efficacy and minimize safety and tolerability concerns.ObjectiveTo investigate the safety and efficacy of halobetasol propionate 0.01% plus tazarotene 0.045% (HP/TAZ) lotion in moderate-to-severe plaque psoriasis.MethodsTwo multicenter, randomized, double-blind, vehicle-controlled phase 3 studies (N = 418) were conducted. Subjects were randomized (2:1) to HP/TAZ lotion or vehicle once daily for 8 weeks with a 4-week follow-up. The primary efficacy assessment end point was treatment success (at least a 2-grade improvement from baseline in Investigator's Global Assessment score and a score of clear or almost clear). Safety and treatment-emergent adverse events were evaluated throughout.ResultsHP/TAZ lotion demonstrated statistically significant superiority over vehicle within as few as 2 weeks. By week 8, 35.8% (study 1) and 45.3% (study 2) of subjects were treatment successes compared with 7.0% and 12.5% of those treated with vehicle (P < .001). HP/TAZ lotion was also superior in reducing signs and symptoms of psoriasis and body surface area affected by psoriasis. The most frequently reported treatment-related adverse events were contact dermatitis (6.3%), application site pain (2.6%), and pruritus (2.2%).LimitationsStudies did not include subjects with more than 12% of their body surface area affected by psoriasis.ConclusionsHP/TAZ lotion was associated with significant reductions in the severity of the clinical signs of psoriasis, with no safety concerns.
PROSPECTIVE RANDOMIZED CONTROLLED TRIAL COMPARING EFFICACY OF 1-L PEG-ASC WITH PRUCALOPRIDE AND 2-L PEG-ASC FOR BOWEL PREPARATION
Authors: YT Jeen, SY Seol, SJ Choi, G Min, W Kim, JM Lee, SH Kim, JM Lee, HS Choi, ES Kim, B Keum, HJ Chun, HS Lee, CD Kim
Journal: Endoscopy (2018)

Though numerous researches enabled decrease of the bowel preparation solution volume, it is still a major complaint of patients preparing colonoscopy. There have been studied that additional administration of laxatives could lessen the amount of aqueous formula with prokinetic effect. Prucalopride is a serotonin (5-HT4) receptor agonist which stimulate colonic mass movements and provide main propulsive force for defecation. The aim of this study is to compare 2-L PEG-Asc and 1-L PEG-Asc plus prucalopride for quality of bowel cleansing while preparing for colonoscopy and patient compliance.
Inhibition of HCV RNA synthesis by the expression of RNA structural mimicry
Authors: Robert Smolic, Robert M. Smith, Martina Volarevic, John H. Andorfer, Catherine H. Wu, George Y. Wu
Journal: Hepatology (2008)

HCV infection is a difficult health problem worldwide. A number of strategies are being studied for their potential in future therapy. Potent sequence-specific inhibition of RNA is now available in the form of RNA interference (RNAi) technology. However, the problem of viral RNA inaccessibility, and the escape of genetic mutants due to high mutation rates of HCV virus still remains. AIM: The objective of this study was to develop an alternative RNA-based approach by over expression of mimicry RNAs with a secondary structure corresponding to cis-acting replication elements of HCV RNA 3-terminal regions. The lack of dependence on sequence complementarity could result in inhibition of viral RNA replication while minimizing the development mutation driven resistance. Methods: Structural mimics were constructed based on RNA sequences of the HCV 1b subgenomic replicon, BB7. The HCV RNA sequence was predict 5B RNA mimic to adopt stem-loop structures identical to the corresponding cis-acting replication element in full-length viral RNA (7600- 7694 nt, NS5B coding region SL 3.1, 3.2) using mfold ver 3.1. DNA fragments containing mimic sequences flanked by BamH I and Hind III sites were generated by amplification of sequences from pHCV replbBB7 and verified by sequencing. To determine effects of structural mimics on HCV infection, an Huh 7.5 cell line was infected with HCV-JFH 1 virus. Cells supporting stable propagation of JFH virus after 5 days of infection were transfected with expression vectors generating HCV structural mimics from pSilencer 4.1 CMV for 48 hrs. Cellular HCV RNA levels were quantitated by Real-Time SYBR Green PCR using HCV specific primers. Lactate dehydrogenase A mRNA levels in each sample was used to normalize JFHv cDNA levels. A HBV specific structural mimic was used as a negative control . Western blot analysis was performed using anti-HCV antibodies to determine if the 5B RNA mimic could reduce levels of HCV proteins. Results: An 8-fold reduction of HCV RNA in Huh 7.5 cells infected with HCV-JFHv-1 was seen on day 2 after HCV 5B RNA mimic treatment compared to negative control HBV RNA-mimic treatment by Real-Time PCR. Conclusions: These results suggest that RNAs that mimic HCV structures corresponding to cis-acting replication elements of HCV RNA inhibit viral RNA replication and deserve further evaluation for the treatment of hepatitis C. This strategy may be advantageous over other sequence-specific gene therapy modalities in circumventing the problem of viral RNA inaccessibility and the escape of genetic variants.
SINGLE-CENTER EXPERIENCE ON OVER-THE-SCOPE-CLIP (OTSC) AS FIRST LINE THERAPY IN NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING
Authors: P Soriani, VG Mirante, C Barbera, T Gabbani, L Miglioli, M Manno
Journal: Endoscopy (2018)

The over-the-scope clip (OTSC; Ovesco, Tubingen, Germany) is an endoscopic clipping device designed for tissue approximation. This tool has been used in the closure of fistulas and perforations. We hereby report a series of patients with high-risk non-variceal upper gastrointestinal bleeding (NVUGIB) lesions in whom OTSCs were used as first-line endoscopic treatment. We prospectively collected and retrospectively analysed data over a period of 48 months from November 2013 to October 2017 from all consecutive patients who underwent emergency endoscopy for acute severe high-risk NVUGIB and were treated with OTSC as primary first-line therapy.
COMPARISON OF CLINICAL OUTCOMES BETWEEN PLASTIC STENT AND LUMEN APPOSING METAL STENT FOR PANCREATIC PSEUDOCYST DRAINAGE
Authors: CM Cho, HC Shin, SJ Yeo, MK Jung, GC Kim
Journal: Endoscopy (2018)

Endoscopic ultrasound (EUS)-guided transluminal drainage for pancreatic pseudocyst (PP) is steadily increasing and has become the first-line treatment. Although lumen apposing metal stent (LAMS) was recently introduced and its feasibility and safety was established by several clinical trials, there was no data for clinical outcomes of PP drainage. We retrospectively reviewed patient with PP who underwent endoscopic ultrasound-guided PP drainage by using plastic stent (PS) or LAMS and compared clinical outcomes between two stents.
EFFECTIVENESS OF REPEATED DILATIONS IN THE MANAGEMENT OF ESOPHAGEAL BENIGN STRICTURES
Authors: A Benezech, A Debourdeau, JM Gonzalez, M Barthet
Journal: Endoscopy (2018)

Refractory esophageal benign strictures (REBS) are defined as the impossibility to reach or maintain a diameter of 14 mm after 5 sessions of endoscopic dilation (ED). Their management remains challenging. The aim of this study was to define the efficacy of long-term and repeated ED in the management of REBS.
EFFECT OF INTRAGASTRIC BALLOON-INDUCED WEIGHT LOSS ON BODY COMPOSITION, FATTY LIVER AND CO-MORBIDITIES IN EGYPTIAN MIDDLE-AGED OBESE FEMALES: A SIX-MONTH FOLLOW-UP STUDY
Authors: A Shamseya, M Shamseya, M Madkour, K Aly Abdelaaty
Journal: Endoscopy (2018)

A group of obese middle-aged Egyptian female subjects treated with intragastric balloon to induce weight loss was prospectively followed up and reported its effect on their anthropometric measurements, body composition, fatty liver and co-morbidities.
OUTCOMES OF ENDOSCOPIC MUCOSAL RESECTION OF LARGE NON-PEDUNCULATED COLORECTAL POLYPS – A PROSPECTIVE STUDY FROM A PORTUGUESE REFERRAL CENTER
Authors: G Alexandrino, T Dias Domingues, L Lourenço, R Carvalho, J Reis
Journal: Endoscopy (2018)

Endoscopic mucosal resection (EMR) has been shown to be useful in the removal of large non-pedunculated colorectal polyps (LNPCP), avoiding the need for surgical resection. We aimed to prospectively evaluate the success, complications and recurrence with EMR in the management of LNPCP.
Pharmacokinetics of tuberculosis drugs in HIV-infected patients from Irkutsk, Russian Federation: redefining drug activity
Authors: Galina Lyles, Oleg Ogarkov, Svetlana Zhdanova, Charles A. Peloquin, Andrew Ebers, Herman Pfaeffle, Mohammad H. Al-Shaer, Elena Moiseeva, Elena Zorkaltseva, Mikhail Koscheev, Eric R. Houpt, Scott K. Heysell
Journal: European Respiratory Journal (2018)

The Russian Federation has the third highest burden of multidrug-resistant (MDR) tuberculosis (TB) in the world, accounting for 10.5% of cases worldwide [1]. Management of the drug-resistant TB epidemic in the Siberian province of Irkutsk is further complicated by high rates of HIV co-infection [2], which leads to early mortality and risk for acquired Mycobacterium tuberculosis drug resistance [3]. Such poor treatment outcomes may be in part a consequence of pharmacokinetic variability rendering subtherapeutic drug concentrations [4–6]. Serum area under the concentration curve (AUC) is the pharmacokinetic parameter correlative with efficacy for most concentration-dependent TB drugs [7, 8] and AUC/minimum inhibitory concentration (MIC) ratio can be further used to predict treatment response [9]. However, relatively few studies have examined the pharmacokinetics of MDR-TB drugs, and none from HIV-infected patients in the Russian Federation. The following prospective cohort study of HIV-TB co-infected patients in Irkutsk was performed to describe pharmacokinetic variability and MIC ranges, and determine if drug activity associates with treatment response. The setting was hypothesised to be particularly informative given the high incidence of MDR- and extensively drug-resistant (XDR)-TB and routine use of novel treatment strategies, including high-dose isoniazid. In Irkutsk, drug concentration testing of TB medications can improve outcomes in HIV-TB co-infected patients <http://ow.ly/bj4a30jkqum>