tbuckley/cabot-search huggingface dataset:
Incidence of End-Stage Renal Disease Attributed to Diabetes Among Persons with Diagnosed Diabetes — United States and Puerto Rico, 2000–2014
Authors: Nilka Rios Burrows, Israel Hora, Linda S. Geiss, Edward W. Gregg, Ann Albright
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

During 2014, 120,000 persons in the United States and Puerto Rico began treatment for end-stage renal disease (ESRD) (i.e., kidney failure requiring dialysis or transplantation) (1). Among these persons, 44% (approximately 53,000 persons) had diabetes listed as the primary cause of ESRD (ESRD-D) (1). Although the number of persons initiating ESRD-D treatment each year has increased since 1980 (1,2), the ESRD-D incidence rate among persons with diagnosed diabetes has declined since the mid-1990s (2,3). To determine whether ESRD-D incidence has continued to decline in the United States overall and in each state, the District of Columbia (DC), and Puerto Rico, CDC analyzed 2000-2014 data from the U.S. Renal Data System and the Behavioral Risk Factor Surveillance System. During that period, the age-standardized ESRD-D incidence among persons with diagnosed diabetes declined from 260.2 to 173.9 per 100,000 diabetic population (33%), and declined significantly in most states, DC, and Puerto Rico. No state experienced an increase in ESRD-D incidence rates. Continued awareness of risk factors for kidney failure and interventions to improve diabetes care might sustain and improve these trends.
Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence
Authors: Chandan Sharma, Hong-Xing Wang, Qinglin Li, Konstantin Knoblich, Emily S. Reisenbichler, Andrea L. Richardson, Martin E. Hemler
Journal: Cancer Research (2017)

DHHC-type protein acyltransferases may regulate the localization, stability, and/or activity of their substrates. In this study, we show that the protein palmitoyltransferase DHHC3 is upregulated in malignant and metastatic human breast cancer. Elevated expression of DHHC3 correlated with diminished patient survival in breast cancer and six other human cancer types. ZDHHC3 ablation in human MDA-MB-231 mammary tumor cell xenografts reduced the sizes of both the primary tumor and metastatic lung colonies. Gene array data and fluorescence dye assays documented increased oxidative stress and senescence in ZDHHC3-ablated cells. ZDHHC3-ablated tumors also showed enhanced recruitment of innate immune cells (antitumor macrophages, natural killer cells) associated with clearance of senescent tumors. These antitumor effects were reversed upon reconstitution with wild-type, but not enzyme-active site-deficient DHHC3. Concomitant ablation of the upregulated oxidative stress protein TXNIP substantially negated the effects of ZDHHC3 depletion on oxidative stress and senescence. Diminished DHHC3-dependent palmitoylation of ERGIC3 protein likely played a key role in TXNIP upregulation. In conclusion, DHHC3-mediated protein palmitoylation supports breast tumor growth by modulating cellular oxidative stress and senescence. Cancer Res; 77(24); 6880-90. ©2017 AACR.
The Use of PET/CT and Bone Marrow Aspiration/Biopsy in Initial Staging Evaluation of Adolescent and Adult Ewing Sarcomas
Authors: Chiaki Inagaki, Tatsunori Shimoi, Hitomi Okuma, Akihiko Shimomura, Emi Noguchi, Mayu Yunokawa, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara, Kenji Tamura
Journal: Annals of Oncology (2017)
Abstract 12198: Effect of Repeat Intravenous Infusion of Vepoloxamer (Purified Sodium-Free Poloxamer 188) on Left Ventricular Systolic Function in Dogs With Advanced Heart Failure
Authors: Hani N Sabbah, Mengjun Wang, Kefei Zhang, Ramesh C Gupta, Marty Emanuele
Journal: Circulation (2015)

Introduction: Ca 2+ overload occurs in heart failure (HF) leading to cardiomyocyte dysfunction and death. Vepoloxamer (VEPO), purified sodium-free poloxamer 188, is a rheologic agent that, in HF, has been suggested to improve microvascular blood flow and repair damaged cell membranes, possibly inhibiting unregulated Ca 2+ entry into cardiomyocytes. We examined the effects of repeat acute i.v. infusion of VEPO on LV function in dogs with microembolization-induced HF (LV ejection fraction, EF~30%). Methods: 14 HF dogs were randomized to 2 hours infusions of VEPO (450 mg/kg, n=7) or v/v normal saline (control, n=7). Each dog received 2 infusions of VEPO or saline 3 weeks apart. Dogs were followed for an additional 3 weeks after the 2 nd infusion (total follow-up 6 weeks). LV end-diastolic (EDV) and end-systolic (ESV) volumes, EF, and plasma n-terminal-pro brain natriuretic peptide (nt-pro BNP) were measured at baseline, at end infusion 1 st infusion, and at 24 hours, 1, 2 and 3 weeks thereafter and then again at 24 hours, 1, 2 and 3 weeks after the 2 nd infusion. The change between baseline and other time points (treatment effect, Δ) was calculated. Results: Data are shown in the table. Saline had no effect on any measures. Compared to saline control, VEPO reduced ESV and nt-pro BNP and increased EF without affecting EDV, heart rate or aortic pressure. The benefits were sustained for up to at least 2 weeks after the 1 st VEPO dose and up to 3 weeks after the 2 nd dose. Conclusions: Therapy with multiple intravenous 2 hours infusions of VEPO, pulsed at 3 week intervals, elicit progressively sustained improvement in LV systolic function evident for at least 6 weeks. The results support development of MST-188 for the treatment of acute HF and potentially for continued therapy post-hospital discharge.
TCT-29 Mechanism of Low Fractional Flow Reserve in Lesions without angiographic significant stenosis: Role of hidden Plaque Burden
Authors: Jonghanne Park, Joo Myung Lee, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Doyeon Hwang, Tae-Min Rhee, Chee Hae Kim, Jung-Kyu Han, Han-Mo Yang, Bon-Kwon Koo, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2017)
TCT-397 Edoxaban versus Standard of Care and their Effects on Clinical Outcomes in Patients having undergone Transcatheter Aortic Valve Implantation in Atrial Fibrillation – Rationale and Design of the ENVISAGE-TAVI AF Trial
Authors: Nicolas Van Mieghem, Marco Valgimigli, Roxana Mehran, Eric Boersma, Usman Baber, Christian Hengstenberg, Minggao Shi, Roland Vranckx
Journal: Journal of the American College of Cardiology (2017)
TCT-76 Impact of Post-Discharge Dual Antiplatelet Therapy vs. Aspirin Alone After CABG in Patients with Left Main Disease: Results from the EXCEL Trial
Authors: Christopher Kelly, Joseph Sabik, A. Pieter Kappetein, William Brown, Nicolas Noiseux, Jose Pomar, Yiran Zhang, Patrick Serruys, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
TCT-298 Incidence, Predicting Factors, and Clinical Outcomes of Periprocedural Myocardial Infarction after Percutaneous Coronary Intervention of Chronic Total Occlusion in the new-generation drug-eluting stents era
Authors: Jin-Ho Kim, Byeong-Keuk Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Journal: Journal of the American College of Cardiology (2017)
TCT-97 Culprit lesion versus multi-vessel intervention in patients with cardiogenic shock complicating myocardial infarction: Incidence and outcomes from The London Heart Attack Group
Authors: Krishnaraj Rathod, Sudheer Koganti, Ajay Jain, Charles Knight, Anthony Mathur, Alexander Sirker, Constantinos O’Mahony, Andrew Wragg, Daniel Jones
Journal: Journal of the American College of Cardiology (2017)
P1.05-066 Impact of Micropapillary Pattern in Nodal Upstaging of Lung Adenocarcinoma 2cm or Less
Authors: Hirotsugu Yamazaki, Yasuto Kondo, Masahito Naito, Hiroyasu Nakashima, Yoshio Matsui, Kazu Shiomi, Yukitoshi Satoh
Journal: Journal of Thoracic Oncology (2017)
Brote de triquinosis humana asociado al consumo de carne de caballo en Italia
Authors: E Pozio, D Sacchini, P Boni, A Tamburrini, F Alberici, F Paterlini
Journal: Eurosurveillance (1998)

La triquinosis es endemica entre los mamiferos en estado salvaje en Italia, aunque el numero de infecciones que causa en seres humanos es muy bajo y generalmente se debe al consumo de carne de cerdos que hozan en zonas silvestres o de jabalies (1). La mayoria de los casos de triquinosis humana en Italia se deben al consumo de carne de caballo (902 casos en cuatro brotes entre 1975 y 1990) (2). El 22 de enero de 1998 fueron importados de Polonia 27 caballos para ser sacrificados en el matadero de una empresa privada de Brescia, en el norte de Italia. Las pruebas rutinarias de triquinosis llevadas a cabo el 26 de enero en el Instituto Zooprofilactico Experimental de Brescia (Istituto Zooprofilattico Sperimentale, IZS) detectaron la infeccion de uno de los caballos.
TCT-651 Coronary Risk Factors Associated with OCT Macrophage Images and their Response After CoCr Everolimus-Eluting Stent Implantation in Patients with Stable Coronary Artery Disease: Subanalysis of the MECHANISM-Elective study
Authors: Yuya Taguchi, Tomonori Itoh, Hideto Oda, Yohei Uchimura, Kyosuke Kaneko, Tsubasa Sakamoto, Iwao Goto, Masafumi Sakuma, Masaru Ishida, Yoshihiro Morino, Daisuke Terashita, Hiromasa Otake, Toshiro Shinke
Journal: Journal of the American College of Cardiology (2017)
Abstract 14468: Atrial Fibrillation-Related Nuclear Calcium Remodeling and Transcriptional Signaling
Authors: Xiao-Yan Qi, Feng Xiong, Louis Villeneuve, Yoshihiro Sobue, Senka Ljubojevic, Donald M Bers, Stanley Nattel
Journal: Circulation (2016)

Introduction: Atrial fibrillation (AF) is the most common clinical arrhythmia, and contributes to cardiovascular morbidity and mortality. AF-related remodeling is mechanistically important but unde...
TCT-324 Rehospitalization after percutaneous coronary intervention
Authors: Kirstine Hansen, Kristoffer Bendix, Lisbeth Antonsen, Karsten Veien, Michael Maeng, Anders Junker, Evald Christiansen, Johnny Kahlert, Lotte Christensen, Christian Oliver Fallesen, Lisette Okkels Jensen
Journal: Journal of the American College of Cardiology (2017)
Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates
Authors: Niña G. Caculitan, Josefa dela Cruz Chuh, Yong Ma, Donglu Zhang, Katherine R. Kozak, Yichin Liu, Thomas H. Pillow, Jack Sadowsky, Tommy K. Cheung, Qui Phung, Benjamin Haley, Byoung-Chul Lee, Robert W. Akita, Mark X. Sliwkowski, Andrew G. Polson
Journal: Cancer Research (2017)

Antibody-drug conjugates (ADC) are designed to selectively bind to tumor antigens via the antibody and release their cytotoxic payload upon internalization. Controllable payload release through judicious design of the linker has been an early technological milestone. Here, we examine the effect of the protease-cleavable valine-citrulline [VC(S)] linker on ADC efficacy. The VC(S) linker was designed to be cleaved by cathepsin B, a lysosomal cysteine protease. Surprisingly, suppression of cathepsin B expression via CRISPR-Cas9 gene deletion or shRNA knockdown had no effect on the efficacy of ADCs with VC(S) linkers armed with a monomethyl auristatin E (MMAE) payload. Mass spectrometry studies of payload release suggested that other cysteine cathepsins can cleave the VC(S) linker. Also, ADCs with a nonprotease-cleavable enantiomer, the VC(R) isomer, mediated effective cell killing with a cysteine-VC(R)-MMAE catabolite generated by lysosomal catabolism. Based on these observations, we altered the payload to a pyrrolo[2,1-c][1,4]benzodiazepine dimer (PBD) conjugate that requires linker cleavage in order to bind its DNA target. Unlike the VC-MMAE ADCs, the VC(S)-PBD ADC is at least 20-fold more cytotoxic than the VC(R)-PBD ADC. Our findings reveal that the VC(S) linker has multiple paths to produce active catabolites and that antibody and intracellular targets are more critical to ADC efficacy. These results suggest that protease-cleavable linkers are unlikely to increase the therapeutic index of ADCs and that resistance based on linker processing is improbable. Cancer Res; 77(24); 7027-37. ©2017 AACR.
LONG TERM OUTCOMES OF TAVR ON PARADOXICAL LOW FLOW LOW GRADIENT SEVERE AORTIC STENOSIS
Authors: Abdulah Alrifai, Mohamad Kabach, Jesus Pino, Pradeep Dayanand, Edwin Grajeda, Swethika Sundaravel, Eduardo Venegas, Lawrence Lovitz, Mark Rothenberg, Roberto Cubeddu, Cristiano Faber, Marcos Nores, Zaher Fanari
Journal: Journal of the American College of Cardiology (2018)
PRE-Transplant Positron Emission Tomography (PET) Predicts Outcomes of Patients with Hodgkin disease Undergoing Reduced Intensity Conditioning Haploidentical Transplant
Authors: Carlo Marani, Silvia Morbelli, Anna Maria Raiola, Alida Dominietto, Giulia Ferrarazzo, Sandro Nati, Marina Congiu, Stefania Bregante, Riccardo Varaldo, Francesca Gualandi, Emanuele Angelucci
Journal: Blood (2016)
Changes in Albuminuria and the Risk of Major Clinical Outcomes in Diabetes: Results From ADVANCE-ON
Authors: Min Jun, Toshiaki Ohkuma, Sophia Zoungas, Stephen Colagiuri, Giuseppe Mancia, Michel Marre, David Matthews, Neil Poulter, Bryan Williams, Anthony Rodgers, Vlado Perkovic, John Chalmers, Mark Woodward
Journal: Diabetes Care (2017)

OBJECTIVE To assess the association between 2-year changes in urine albumin–to–creatinine ratio (UACR) and the risk of clinical outcomes in type 2 diabetes. RESEARCH DESIGN AND METHODS We analyzed data from 8,766 participants in the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation Post-Trial Observational Study (ADVANCE-ON). Change in UACR was calculated from UACR measurements 2 years apart, classified into three groups: decrease in UACR of ≥30%, minor change, and increase in UACR of ≥30%. By analyzing changes from baseline UACR groups, categorized into thirds, we repeated these analyses accounting for regression to the mean (RtM). The primary outcome was the composite of major macrovascular events, renal events, and all-cause mortality; secondary outcomes were these components. Cox regression models were used to estimate hazard ratios (HRs). RESULTS Over a median follow-up of 7.7 years, 2,191 primary outcomes were observed. Increases in UACR over 2 years independently predicted a greater risk of the primary outcome (HR for ≥30% UACR increase vs. minor change: 1.26; 95% CI 1.13–1.41), whereas a decrease in UACR was not significantly associated with lower risk (HR 0.93; 95% CI 0.83–1.04). However, after allowing for RtM, the effect of “real” decrease in UACR on the primary outcome was found to be significant (HR 0.84; 95% CI 0.75–0.94), whereas the estimated effect on an increase was unchanged. CONCLUSIONS Changes in UACR predicted changes in the risk of major clinical outcomes and mortality in type 2 diabetes, supporting the prognostic utility of monitoring albuminuria change over time.
TCT-123 Pressure-Controlled Intermittent Coronary Sinus Occlusion Reduces Infarct Size After primary PCI: A propensity-controlled matched study
Authors: Mohaned Egred, Roger Kessels, Alan Bagnall, Ioakim Spyridopoulos, Nick Palmer, Ever Grech, Ajay Jain, Gregg Stone, Robin Nijveldt, Thomas McAndrew
Journal: Journal of the American College of Cardiology (2017)
TCT-772 The Effect of Appropriate Implant Position for the Evolut R Self-Expanding Transcatheter Aortic Valve: Analysis from the FORWARD Study
Authors: Ganesh Manoharan, Eberhard Grube, Nicolas Van Mieghem, Johan Bosmans, Thomas Modine, Sabine Bleiziffer, Axel Linke, Werner Scholtz, Stephan Windecker
Journal: Journal of the American College of Cardiology (2017)
Cyclooxygenase-2 dependent expression of angiogenic CXC chemokines, ENA-78/CXCL5 and IL-8/CXCL8, in human non-small cell lung cancer
Authors: Mehis Pold, Li X. Zhu, Sherven Sharma, Marie D. Burdick, Ying Lin, Anu Pold, Jie Luo, Kostyantin Krysan, Mariam Dohadwala, Jenny T. Mao, Raj K. Batra, Robert M. Strieter, Steven M. Dubinett
Journal: Cancer Research (2004)

4942  Elevated tumor cyclooxygenase 2 (COX-2) activity plays a multifaceted role in non-small cell lung cancer (NSCLC). To elucidate the role of COX-2 in the in vitro and in vivo expression of two known NSCLC angiogenic peptides, CXCL8 and CXCL5, we studied two COX-2 gene modified NSCLC cell lines, A549 and H157. COX-2 overexpression enhanced the in vitro expression of both CXCL8 and CXCL5. In contrast, specific COX-2 inhibition decreased the in vitro production of both peptides. Consistent with the COX-2 in vitro effects, the enhanced tumor growth of COX-2 expressing tumors in a SCID-mouse model of NSCLC was accompanied by elevated levels of CXCL5 and CXCL8. Furthermore, neutralizing anti-CXCL5 and anti-CXCL8 antisera inhibited the tumor growth of COX-2 overexpressing tumors in SCID-mice. In addition, the COX-2 related angiogenic capacity of H157 was efficiently reduced by anti-CXCR2 treatment in a rat corneal pocket model of angiogenesis. In summary, we conclude that COX-2 contributes to the progression of NSCLC tumorigenesis by enhancing the expression of angiogenic chemokines CXCL8 and CXCL5. Further studies will be required to determine if COX-2 inhibitors can regulate angiogenic chemokines in lung cancer patients.
4B.03 Prospective Evaluation of Multidisciplinary Lung Cancer Care: Timeliness, Thoroughness, and Patient/Caregiver Perspectives
Authors: M. Smeltzer, F.E. Rugless, H.K. Lee, K. Ward, N.R. Faris, M.A. Ray, M. Meadows, B. Jiang, B. Jackson, C. Foust, A. Patel, N. Boateng, S. Kedia, K. Roark, C. Houston-Harris, C. Fehnel, R.S. Signore, R. Fox, E.T. Robbins, J. Li, R.U. Osarogiagbon
Journal: Journal of Thoracic Oncology (2017)
Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence
Authors: Marcos Rios Garcia, Brigitte Steinbauer, Kshitij Srivastava, Mahak Singhal, Frits Mattijssen, Adriano Maida, Sven Christian, Holger Hess-Stumpp, Hellmut G. Augustin, Karin Müller-Decker, Peter P. Nawroth, Stephan Herzig, Mauricio Berriel Diaz
Journal: Cell Metabolism (2017)
Resistencia bacteriana a los antibióticos en Francia: una prioridad para la salud pública
Authors: H Aubry Damon, J Carlet, P Courvalin, J C Desenclos, J Drucker, D Guillemot, V Jarlier, B Régnier, B Schlemmer
Journal: Eurosurveillance (2000)

Desde hace varios anos, Francia ha debido hacer frente a una rapida propagacion de resistencias a los agentes antimicrobianos en hospitales y consultas generales, a pesar de las diversas recomendaciones formuladas para solucionar este problema. En 1999, el Instituto de Vigilancia Sanitaria convoco a los especialistas del pais y posteriormente realizo una consulta nacional que reunio a todos los profesionales de la salud del pais que colaboran en la investigacion de resistencias bacterianas. Esta consulta finalizo con propuestas para un plan nacional de medidas destinadas a controlar estas resistencias que fueron presentadas ante el Ministerio de Sanidad frances.
TCT-702 Multi-vessel Vasospastic Angina as a Strong Independent Predictor for Cardiovascular Outcome; Vasospastic Angina in Korea (VA-KOREA) registry
Authors: Seung Hwan Han, Youngkeun Ahn, Byoung Kwon Lee, Hyeon Cheol Gwon, Hyuck Moon Kwon
Journal: Journal of the American College of Cardiology (2017)
TCT-471 The prognostic implications of a single higher contrast volume procedure vs. separate lower contrast volume staged procedures for percutaneous coronary intervention: a decision-analytical model to define the threshold for contrast:glomerular filtration ratio in determining the optimum strategy
Authors: Navin Chandra, Peter Moore, Imad Nadra, David Wood, Sean Hardiman, Lilian Ding, Anthony Fung, Eve Aymong, Albert Chan, Steven Hodge, Kevin Horgan, Adeera Levin, Simon Robinson, Anthony Della Siega
Journal: Journal of the American College of Cardiology (2017)
Child admissions to intensive care rise 15% in England since 2009
Authors: Jacqui Wise
Journal: BMJ (2017)

The number of children admitted to intensive care in England has risen sharply since 2009, placing additional strain on the NHS, a study has found.1 The authors said that the rise was not explained by an increasing child population or by any change in admission criteria to paediatric intensive care units.

The researchers analysed data from the Paediatric Intensive Care Audit Network on children aged 15 and under from 2004 to 2013. They also analysed population data from the Office for …
DnaJ Heat Shock Protein Family B Member 9 Is a Novel Biomarker for Fibrillary GN
Authors: Surendra Dasari, Mariam P. Alexander, Julie A. Vrana, Jason D. Theis, John R. Mills, Vivian Negron, Sanjeev Sethi, Angela Dispenzieri, W. Edward Highsmith, Samih H. Nasr, Paul J. Kurtin
Journal: Journal of the American Society of Nephrology (2017)

Fibrillary GN (FGN) is a rare primary glomerular disease. Histologic and histochemical features of FGN overlap with those of other glomerular diseases, and no unique histologic biomarkers for diagnosing FGN have been identified. We analyzed the proteomic content of glomeruli in patient biopsy specimens and detected DnaJ heat shock protein family (Hsp40) member B9 (DNAJB9) as the fourth most abundant protein in FGN glomeruli. Compared with amyloidosis glomeruli, FGN glomeruli exhibited a &gt;6-fold overexpression of DNAJB9 protein. Sanger sequencing and protein sequence coverage maps showed that the DNAJB9 protein deposited in FGN glomeruli did not have any major sequence or structural alterations. Notably, we detected DNAJB9 in all patients with FGN but not in healthy glomeruli or in 19 types of non-FGN glomerular diseases. We also observed the codeposition of DNAJB9 and Ig- γ . Overall, these findings indicate that DNAJB9 is an FGN marker with 100% sensitivity and 100% specificity. The magnitude and specificity of DNAJB9 overabundance in FGN also suggests that this protein has a role in FGN pathogenesis. With this evidence, we propose that DNAJB9 is a strong biomarker for rapid diagnosis of FGN in renal biopsy specimens.