tbuckley/cabot-search huggingface dataset:
THU0141 Can we predict thrombotic tendency in rheumatoid arthritis: a thromboelastographic analysis
Authors: S Türk, D Üsküdar Cansu, H Üsküdar Teke, T Kaşifoğlu, M Akay, M Bilgin, C Korkmaz
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Arterial and venous thromboembolism were proven to be increased in cases with rheumatoid arthritis (RA) (1). It would be interesting to predict thrombosis in these patients by a laboratory test. Rotational thromboelastography (ROTEM) is a viscoelastometric clotting test to evaluate the kinetics of clot formation and fibrinolysis which provides global information on cellular and soluble procoagulant/anticoagulant protein interactions. <h3>Objectives</h3> Our aim was to determine the thrombosis predisposition in RA patients by thromboelastography and to identify the possible clinical and laboratory risk factors for thrombotic tendency in RA patients. <h3>Methods</h3> 85 RA patients (mean age: 54.12±13 yrs; female: 66 (77.6%) diagnosed based on 2010 ACR/EULAR classification criteria were sequentially recruited. Patients were receiving either conventional synthetic disease modifying antirheumatic drugs (csDMARD) or were receiving biological treatments. Age- and gender matched 35 healthy individuals were enrolled as a control group. Complete blood count (CBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured and DAS-28 scores were calculated. ROTEM was applied at the same time and clotting time (CT, seconds), clot formation time (CFT, seconds), and maximum clot firmness (MCF, mm) were determined. A shorter CT and/or CFT values and/or a higher MCF levels imply tendency towards hypercoagulability. <h3>Results</h3> RA patients with a higher disease activity were found to have a shorter I-CFT and a higher I-MCF (p values p=0.020, p=0.033, respectively). Correlation analysis revealed shorter I-CFT and E-CFT and higher I-MCF and E-MCF in those with more active disease, hence indicating a higher tendency to thrombosis. DAS-28 score, high level of CRP, and increased platelet count were identified as variants affecting thromboelastography in favor of thrombosis susceptibility. <h3>Conclusions</h3> Disease activation in RA patients may lead to hypercoagulability, independent of the ongoing medication of patients. Considering the fact that the predictive value of ROTEM parameters for further thrombosis, additional studies are needed whether pro-thrombotic state in RA may herald thrombosis in the presence of inflammation. <h3>References</h3> Mameli A, Barcellona D, Marongiu F. Rheumatoid arthritis and thrombosis. Clin Exp Rheumatol. 2009;27:846–55. <h3>Acknowledgements</h3> None. <h3>Disclosure of Interest</h3> None declared
INJURIES IN ELITE AUSTRALIAN FEMALE CRICKETERS
Authors: Nirmala Perera, Alex Kountouris, Joanne Kemp, Corey Joseph, Caroline Finch
Journal: British Journal of Sports Medicine (2017)

Background Cricket Australia has a well-established injury surveillance program for its elite male players and has published regular reports. Whilst injury data has been collected for the elite female players, it has not been published to date. Objective To establish injury profiles sustained by elite female players by utilising the data collected through the Cricket Australia's Athlete Management System. Design Cohort study, 2014–16 seasons. Setting International and national cricket. Participants Elite women. Main Outcome Measurements Incidence, nature and anatomical location and mechanism of injuries. Results The mean age of the 121 players was 24.2 years (SD ±4.5). 113 players sustained 600 injuries; 77.7% (n=94) sustained ≥1 injury. 477 injuries (79.5%) were acute and 73.2% (n=439) were new. Injury match incidence was 424.7 injuries/10,000 hours for all injuries, and 79.3 injuries/10,000 hours for time-loss. Thigh (n=84, 14.0%), wrist (n=77, 12.8%), knee (n=68, 11.3%), shoulder (n=66, 11.0%) and lumbar spine (n=63, 10.5%) were the most frequently injured regions. There were 31.8% (n=191) muscle injuries; 16.0% (n=96) joint sprains. Most injuries occurred via an insidious onset (28.7%, n=172), with running 15.3% (n=92) the most common mechanism. There were 121 (20.2%) time-loss injuries (94 new and 27 recurrent) resulting total of 3638 days (average 30 days, SD ±47.38) away from the sport. Wrist/hand (n=20, 19.80%) and lumbar spine (n=20, 16.5) were the most common time-loss injuries. Six players sustained lumbar-spine stress fractures that resulted in the most days missed due to injury (average 111 days/injury). Conclusions Similarities are evident between male and female cricket injury profiles with the thigh being the most injured location. This is the first study to demonstrate that elite female cricket players also develop lumbar spine stress fractures, similar to their male counterparts. More research is required to determine the mechanisms for injuries in female players.
The Statistical Significance of the Efficacy Results in a Randomized Clinical Trial—Reply
Authors: Evangelos J. Giamarellos-Bourboulis
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Vorinostat plus tacrolimus/methotrexate to prevent GVHD after myeloablative conditioning, unrelated donor HCT
Authors: Sung Won Choi, Thomas Braun, Israel Henig, Erin Gatza, John Magenau, Brian Parkin, Attaphol Pawarode, Mary Riwes, Greg Yanik, Charles A. Dinarello, Pavan Reddy
Journal: Blood (2017)
02.39 Clusterin is increased in idiopathic inflammatory myopathies and is associated with disease activity
Authors: Tereza Lennerová, Lucia Vernerová, Martin Klein, Michal Tomčík, Heřman Mann, Veronika Hrušková, Karel Pavelka, Jiří Vencovský, Ladislav Šenolt
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Clusterin (apolipoprotein J) is an extracellular chaperone involved in the number of biological processes, such as inflammation and apoptosis. Recent data suggest its protective role in autoimmune diseases. The aim of this study was to analyse the serum levels of clusterin and its expression in skeletal muscle specimens in patients with idiopathic inflammatory myopathies (IIM) vs healthy controls, and to investigate the association of clusterin with disease activity. <h3>Materials and methods</h3> Clusterin serum levels were measured by ELISA (Biovendor) in 65 patients with IIM (27 dermatomyositis (DM), 28 polymyositis (PM), 10 immune-mediated necrotizing myopathy (IMNM)) and in 54 healthy individuals. Clusterin mRNA expression was analysed in skeletal muscle samples obtained from muscle biopsy (mini-invasive Bergstrom technique) in 10 patients with IIM (DM/PM) and 10 healthy controls by RT-PCR. Disease activity was assessed using myositis disease activity assessment visual analogue scales (MYOACT), myositis intention to treat index (MITAX), health assessment questionnaire (HAQ) and global disease assessment evaluated by patient and doctor. Data are presented as mean ± SD. <h3>Results</h3> Serum concentrations of clusterin were significantly higher in all patients with IIM compared with healthy controls (87.1±22.8 vs 68.4±12.4, p&lt;0.0001). There were no differences in the clusterin levels among particular myositis subtypes. Clusterin levels in all IIM patients positively correlated with MITAX (r=0.357, p=0.004), MYOACT (r=0.337, p=0.008) and doctor global disease assessment (r=0.309, p=0.015), but not with muscle enzymes. Moreover, mRNA expression of clusterin in muscle tissues was almost three-times higher in patients with IIM than in healthy individuals (p=0.029). <h3>Conclusions</h3> We demonstrate here for the first time increased clusterin expression in myositis patients than in healthy subjects and its association with clinical disease activity. <h3>Acknowledgement</h3> Supported by the project of MHCR for conceptual development of research organisation 00023728 and project NV16-33746A.
PTH-009 Endoscopic closure of acute perforations of the gastrointestinal tract in animal models: a systematic review and meta-analysis
Authors: A Gabr, N Ammar, MEl Houssini, C Summerton, M Rutter
Journal: Endoscopy (2017)

<h3>Introduction</h3> Acute perforations are one of the recognised complications of both diagnostic and therapeutic gastrointestinal endoscopy. For decades, surgical treatment has been the standard of care, but endoscopic closure has become a more popular approach, due to feasibility and the reduction of the burden of surgery, combined with the availability of various endoscopic closure devices.We aimed to assess the technical and clinical success and safety of endoscopic closure, in total, and for each endoscopic device used in closing acute perforations in animal models. <h3>Method</h3> Medical literature (Cochrane library, EMBASE, MEDLINE) from 1966 till September 2016 was searched. A systematic review and meta-analysis were performed on studies reporting technical and clinical success of endoscopic closure of acute perforations, according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. <h3>Results</h3> 46 studies on animal models were identified. 15 studies,including 4 randomised controlled trials, met our inclusion criteria (acute, less than 24 hours, iatrogenic, no fistulas or leaks, clear documentation of the method of closure, and technical and clinical success and 5 cases or more of endoscopic closure per study), were analysed. A total of 214 endoscopic closures were attempted in these studies. The overall technical success rate was 94.8% (n=201/214, 95% CI: 92%&gt;97.6%), clinical success was 92.3% (n=189/214, 95% CI: 88.8%&gt;95.8%), and complication rate was 4.2% (n=6/214, 95% CI: 1.6%&gt;6.8%).Technical success for endoclip closure was 84.9% (95% CI: 71.4%&gt;93.6%), and clinical success was 83.2% (95% CI: 69.5%&gt;92.5%), and complication rate was 2.7% (95% CI: 90.12%&gt;99.88%).For OTSC (Over the scope clip device), technical success was 97% (95% CI: 88%&gt;99.7%), clinical success was 97% (95% CI: 88%&gt;99.7%), and complication rate was 1.87% (95% CI: 91.2%&gt;98.8%).The technical success for endosuturing (endoscopic suturing device) was 92.7% (95% CI: 82% to 98%), clinical success was 87% (95% CI: 74.9%–94.8%), complication rate was 1.9% (95% CI: 91.1%&gt;98.9%). <h3>Conclusion</h3> Our study suggests that endoscopic closure is a suitable treatment option for acute iatrogenic gastrointestinal perforations with a reasonable technical and clinical success, and low complication rate. Further confirmation from prospective studies in human is needed. <h3>Disclosure of Interest</h3> None Declared
Ischemic Pain Testing Demonstrates Hypoxia Dependent Early Pain and Hypoxia Independent Persistent Pain Responses in Adults with Sickle Cell Anemia
Authors: Kathleen Vaughan, Joseph Kim, Daniel Lichy, Nathan S Fishman, Amit Khandhadia, You Keun Kim, Stephen Yoon, Niral Sheth, James Ahad, Hans Ackerman, Inna Belfer, Alexander M. Gorbach, James G. Taylor
Journal: Blood (2016)
Endoscopic retrograde cholangiography after endoscopic ultrasound-related duodenal perforation: keep calm, use over-the-scope clip, and carry on!
Authors: Paola Soriani, Vincenzo Mirante, Carmelo Barbera, Giuseppe Grande, Lucia Miglioli, Mauro Manno
Journal: Endoscopy (2017)

The over-the-scope clip (OTSC) is a useful tool recommended as first-line endoscopic treatment for endoscopic acute iatrogenic perforation [1]. A retrospective study documented that OTSCs can avoid emergency surgical repair, allowing, in some cases, completion of the primary endoscopic procedure. As documented only once in the literature, its use could allow subsequent endoscopic procedures to be performed in the same session, owing to the endurance of the device during pneumatic and mechanical stress [2].
Floor of mouth window to improve surgical access for trans-oral cancer surgery.
Authors: Jeffson Chia-Hsien Chung, Adam Bender-Heine, H. Wayne Lambert
Journal: Journal of Clinical Oncology (2017)

e17568 Background: The increasing incidence of HPV associated oropharyngeal cancer has sparked interest in minimally invasive transoral surgery as a primary treatment modality. However, adequate surgical exposure and access to the tongue base is difficult to achieve. Many complex oral retraction systems have been developed in attempt to solve this problem but none work consistently or efficiently. Methods: This cadaveric study introduces the floor of mouth window – a simple adjunctive procedure done at the time of transoral resection and concurrent neck dissection that greatly improves surgical access to the tongue base while eliminating the need for oral retractors. It involves passing the oral tongue through the floor of mouth into the neck dissection field, thereby creating space for robotic or laser instruments to perform cancer resection. The floor of mouth is closed primarily in layers at the end of the procedure. Results: This study compares the tongue base exposure achievable with existing oral retractors to that achievable utilizing this novel technique. Our finding is that superior surgical exposure is attainable without retractors using the floor of mouth window. In fact, laser resection of the base of tongue was successfully performed in cadavers without the use of any retractors. Conclusions: We believe this technique may have a major impact on the management of oropharyngeal cancers because having a simple, reproducible method to access the tongue base will encourage greater adoption of transoral surgery as a treatment modality. It is a technique that can be helpful regardless of any future advances in robot or laser technology. Furthermore, this technique reduces the reliance on multiple complicated and expensive retraction systems. Finally, the improved exposure and visualization of the tongue base attainable by this new procedure may facilitate clear surgical margins and thus maximize the potential for cure, which is ultimately the objective of all head and neck surgeons.
血小板由来マイクロパーティクル(PDMP)はPCI後再狭窄の予測因子となる
Authors: 藤松大輔, 井上晃男, 挽地裕, 諸岡俊文, 琴岡憲彦, 吉田和代, 松下哲也, 中村郁子, 山崎あゆむ, 薦田洋, 橋本重正, 野出孝一
Journal: Circulation (2007)
Combined effect of anti-BAG3 and anti-PD-1 treatment on macrophage infiltrate, CD8 <sup>+</sup> T cell number and tumour growth in pancreatic cancer
Authors: Vittoria Iorio, Alessandra Rosati, Raffaella D'Auria, Margot De Marco, Liberato Marzullo, Anna Basile, Michelina Festa, Maria Pascale, Paolo Remondelli, Mario Capunzo, Gianluca Sala, Verena Damiani, Giuseppina Amodio, Marta Di Nicola, Rossano Lattanzio, Maria Caterina Turco, Vincenzo De Laurenzi
Journal: Gut (2017)

We read with great interest the article by Zhang et al 1 showing that CD8+ cell infiltration in pancreatic tumours can be enhanced by depletion of myeloid cells (CD11b+ macrophages and myeloid-derived suppressor cells) and that the depletion of CD11b+ cells resulted in decreased PD-L1 expression on cancer cells thus impairing the triggering of the inhibitory receptor PD-1 on T cells.1 Recruitment and activation of CD8+ lymphocytes in tumours are suppressed by mechanisms only partially understood and rescuing CD8+ cell infiltrate in tumours is one of the objectives of immunotherapies.1 2 Tumour-associated macrophages (TAMs) play a crucial role in the relation between tumour cells and their environment.3 Here, we confirm the interplay between macrophages and CD8+ cells in pancreatic cancer and identify a potential way to exploit this enhancing effect of anti-PD-1 treatment. Indeed, we show that reduction of macrophage infiltrate, through treatment with an anti-Bcl-2-Associated athanoGene 3 (BAG3) antibody,4 results in increased number of CD8+ cells in pancreatic tumours in a murine model. BAG3 is a co-chaperone of …
Evaluation of epidermal growth factor receptor tyrosine kinase mutations in patients with primary and metastatic pulmonary nodules.
Authors: Ramin Altaha, Jing Jie Yu, Daniel Flynn, Patricia Stoltzfus, Sylvia McEwuen, Gerry Hobbs, Barbara Ducatman, Geoffrey Graeber, William Petros
Journal: Clinical Cancer Research (2007)

B10  Background: Somatic mutations in epidermal growth factor receptor tyrosine kinase (EGFR-TK) have been associated with tumor response to treatment with EGFR-TK inhibitors. These occur in approximately 13% of non-small cell lung cancer (NSCLC) patients in the United States, but EGFR-TK mutation frequency in lung metastases from cancers originating in other organs is not well studied.  Methods: DNA sequencing was performed on a cohort of rural Appalachian patients who presented with malignant pulmonary nodules. All patients with pulmonary nodules on CT-scan, suspicious for malignancies, were identified between September 2005 and April 2006 and prospectively consented to enroll on an institutional review board-approved study for genetic evaluation of their pulmonary nodules. Patients subsequently underwent diagnostic fine needle aspirates or tumor resection. Tumor DNA from the pulmonary nodules was evaluated by direct sequencing for mutations in exons 18, 19, 20 and 21 of EGFR-TK. All samples were evaluated in duplicate sequencing tests.  Results: Consent for the study was obtained in 37 patients; whereas DNA sequencing was successful in 20 (17 patients did not have sufficient material for DNA sequencing). Eighty-five percent of the sequenced patients were tobacco smokers. EGFR-TK mutations were identified in 55% of the eleven patients with primary pulmonary nodules compared to 57% of the seven patients with metastatic nodules. Twelve of 20 evaluable samples (60%) displayed a previously reported silent mutation (G to A) in exon 20. The distribution was as follows: NSCLC (5/10), small cell lung cancer (1/1), renal cell cancer (1/1), breast cancer (1/2), Non Hodgkin lymphoma (0/1), carcionid (1/1), metastatic tonsillar cancer (1/2), non-diagnostic (1/1) and inflammation (1/1).  Conclusions: Patients with metastatic pulmonary nodules have a similar mutation frequency to those with NSCLC. The exon 20 G to A mutation observed in rural Appalachians with primary pulmonary nodules is markedly higher than that reported in a previous large, multi-center study of NSCLC patients (50% vs. 3%, p
Multicenter prospective randomized controlled trial of comparing laparoscopic proximal gastrectomy and laparoscopic total gastrectomy for upper third early gastric cancer (KLASS-05).
Authors: Do Joong Park, Hyung-Ho Kim, Sang Uk Han, Woo Jin Hyung, Sun-Hwi Hwang, Hoon Hur, Han-Kwang Yang, Hyuk-Joon Lee, Hyoung-Il Kim, Young Woo Kim, Seong-Ho Kong, Han Hong Lee, Youngkyu Park, In Seob Lee, Beom Su Kim, Young-Joon Lee, Ji-Ho Park, Yun-Suhk Suh, Sang-Hoon Ahn
Journal: Journal of Clinical Oncology (2019)

TPS184 Background: Proximal gastrectomy (PG) is rarely performed for upper third early gastric cancer (EGC) because of postoperative reflux esophagitis. Recently, PG with double tract reconstruction was introduced and reported to have a reflux of approximately the same frequency as total gastrectomy (TG) with esophagojejunostomy. PG has several theoretical advantages over TG but has not yet been proven in randomized controlled trial. This study aimed to provide scientific evidence of laparoscopic PG with double tract reconstruction as a standard procedure for proximal EGC. Methods: The present trial is multicenter, prospective, randomized, controlled trial with superiority design. A total of 138 patients with upper third cT1N0M0 gastric adenocarcinoma are randomized to laparoscopic PG with double tract reconstruction and laparoscopic TG with esophagojejunostomy. Patients are enrolled for two years and followed up for two years. Primary co-endpoints are hemoglobin change and vitamin B12 cumulative supplement quantity after 2 years of operation. We used the alpha-split method to set the hemoglobin to 4% and vitamin B12 to 1% for alpha. The sample size needed was 62 patients for each arm. Accounting for 10% follow-up loss, the enrollment of 69 patients in each group was required. Secondary endpoints are prevalence rate of postoperative reflux esophagitis, morbidity and mortality, quality of life 2-year after operations, relapse-free survival, and overall survival. Nineteen investigators from 10 institutes participated in this trial. The first patient was enrolled on October 27, 2016 and we completed the patient enrollment on September 17, 2018. Clinical trial information: NCT02892643.
<scp>NF</scp>‐κB2 Controls the Migratory Activity of Memory T Cells by Regulating Expression of <scp>CXCR</scp>4 in a Mouse Model of Sjögren's Syndrome
Authors: Mie Kurosawa, Rieko Arakaki, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Jonathan Sprent, Naozumi Ishimaru
Journal: Arthritis & Rheumatology (2017)

Dysregulated chemokine signaling contributes to autoimmune diseases by facilitating aberrant T cell infiltration into target tissues, but the specific chemokines, receptors, and T cell populations remain largely unidentified. The aim of this study was to examine the role of the potent chemokine CXCL12 and its receptor CXCR4 in the T cell autoimmune response, using alymphoplasia (aly)/aly mice, a model of Sjögren's syndrome (SS).T cell phenotypes in the salivary gland of aly/aly mice were evaluated using immunologic analysis. An in vitro migration assay was used to assess T cell migratory activity toward several chemokines. Gene expression of chemokine receptors and transforming growth factor β receptors (TGFβRs) was measured by quantitative reverse transcription-polymerase chain reaction. The CXCR4 antagonist AMD3100 was administered to the aly/aly mice in order to evaluate its suppressive effect on autoimmune lesions.Effector memory T (TEM) cells derived from aly/aly mice demonstrated higher in vitro migratory activity toward CXCL12 than did TEM cells from aly/+ mice. CXCL12 expression was specifically up-regulated in the SS target cells of aly/aly mice. TEM cells from RelB-/- mice, but not Nfkb1-/- mice, also showed high migratory activity toward CXCL12, implicating a role of the nonclassical RelB/NF-κB2 pathway in the regulation of TEM cell migration. TEM cells from aly/aly mice also overexpressed TGFβR type I (TGFβRI) and TGFβRII. The CXCR4 antagonist AMD3100 suppressed autoimmune lesions in aly/aly mice by reducing TEM cell infiltration.Our results suggest that the RelB/NF-κB2 pathway regulates T cell migration to autoimmune targets through TGFβ/TGFβR-dependent regulation of CXCL12/CXCR4 signaling. This suggests that these signaling pathways are potential therapeutic targets for the treatment of autoimmune diseases.