tbuckley/cabot-search huggingface dataset:
Abstract 12983: Impact of Door to Balloon Time on Outcome of Patients Presenting With Different Symptom Onset to Door Time
Authors: Razvan T Dadu, Ana Davis, Jaromir Bobek, Mahboob Alam, Rajiv Goswami, Nasser Lakkis
Journal: Circulation (2014)

Objective: Delay in reperfusion &gt; 4h in patients with ST elevation myocardial infarction (STEMI) is associated with negative outcomes. We sought out to examine the impact of DTBT on 30-day cardiovascular outcomes and persistent ST elevation (STE) on the post reperfusion EKG, in patients with different symptom onset to door time (SOTDT). Methods: 122 consecutive patients undergoing primary percutaneous coronary intervention for STEMI in a tertiary care county hospital from 2011-2013 are included. All patients had DTBT ≤ 90min. Patients were divided into 3 groups according to their SOTDT: Group1 ≤ 90min, Group2 between 90min and 4h and Group3 &gt;4h. Each group was further divided in 2 subgroups based on median DTBT of the entire population. The primary outcome was a composite endpoint of mortality, re-hospitalization for chest pain or heart failure, repeat revascularization and re-infarction at 30 days. A secondary outcome was persistence of &gt; 50% STE on the post reperfusion EKG. Results: Median SOTDT was 129 min and the median DTBT was 47min for all included patients in the study. The 3 groups had comparable baseline characteristics. The mean DTBT was similar (49±20 min, 47±18 min and 50±16 min, p=0.7). In the 3 groups, the primary outcome was present in 16.7 %, 16.2 % and 35%, respectively (p=0.08) and there was a significant difference in STE resolution: 16.7%, 17.1% and 78.6%, respectively (p&lt;0.001). Group 1 and 3 demonstrate that short DTBT (≤ 47 min) does not affect overall outcomes compared to those with longer DTBT (&gt; 47 min). In group 2, patients with DTBT ≤ 47min had significantly lower persistent STE on EKG (0% vs 36.8%, p=0.002) and a trend to a favorable clinical outcome (table). Conclusion: Patients with intermediate SOTDT seem to benefit mostly from shorter DTBT compared to all other patient groups. Achieving shorter DTBT may have no impact on outcome in patients with very early or very late presentation. Larger studies are needed to further confirm these findings.
Abstract 46: Legacy Effects of STRRIDE Exercise Training Programs on Cardiometabolic Health Observed Ten Years Later
Authors: William E Kraus, Cris A Slentz, Brian D Duscha, Leslie H Willis, Johanna L Johnson
Journal: Circulation (2016)

Introduction: STRRIDE Reunion evaluated longitudinal changes in cardiometabolic health 10 years after completion of STRRIDE (Studies Targeting Risk Reduction Interventions through Defined Exercise). Subjects originally were randomized to one of four eight-month interventions: inactive control (IC); low amount moderate, intensity exercise (LAMI); low amount, vigorous intensity (LAVI); high amount, vigorous intensity (HAVI). Methods: Of 153 Duke STRRIDE graduates, 28 were lost to followup; 21 declined to participate in the Reunion; 104 were studied. Participants completed medical history and physical activity questionnaires; height, weight, blood pressure, waist circumference, and blood were collected; fitness was assessed on 93. We evaluated change in CMH 10 years after completion relative to assessments taken at the time of original randomization; thus, change scores reflect the original study-related changes plus those persisting over the ensuing ten years (legacy effect). Results: Several independent measures suggested group-specific legacy effects. Mean arterial pressure was lower in LAMI. This was different (P&lt;0.05) from all other groups even after controlling for BP meds and baseline values. LAMI also had a lower fasting insulin; this was different (P&lt;0.05) from IC. Peak VO2 decreased 10-11% over ~11 y in IC and LAMI, but decreased &lt; 5% in both vigorous intensity groups (LAVI, HAVI). IC increased 5.3 kg and 5 cm in waist circumference; however, none of the exercise groups changed significantly in these variables. All exercise groups maintained or improved lipids, blood pressure, body weight, fasting insulin; fasting glucose increased substantially in all groups. Physical activity was maintained more in all exercise groups over follow-up. Conclusions: We observed group-specific legacy effects from a eight-month exercise training program. Whether this was due to maintained physical activity, it demonstrates the power and value for long-term CMH of even moderate term exercise interventions.
Romiplostim for Chemotherapy-Induced Thrombocytopenia (CIT). Results of a Phase 2 Trial
Authors: Gerald A. Soff, Yimei Miao, Sean M. Devlin, Simon Mantha, Jodi V Mones, Valery J Li, Ghassan K Abou-Alfa, Andrea Cercek, Nancy Kemeny, Rekha Parameswaran
Journal: Blood (2017)
Expression of the CD5 Molecule in Chronic Lymphocytic Leukemia
Authors: Aldair Paiva, Gabriela Va Alves, Lenilton Silva Silveira, Erica Aires Gil, Rodolfo Da Soares, Dany Gkc Silva, Rodrigo Villar Freitas, Frank Bahia, Marcelo Rocha Barbosa, Geraldo Barroso Cavalcanti
Journal: Blood (2017)
Retrieval is central to the distinctive function of episodic memory
Authors: Sara Aronowitz
Journal: Behavioral and Brain Sciences (2018)

Abstract Episodic retrieval is heavily and asymmetrically dependent on the temporal order of the remembered events. This effect, or rather the underlying structure which it reflects, is a distinctive feature missing from the account in the target article. This structure explains significant successes and failures of episodic retrieval, and it has clear consequences for the fitness of the organism extending beyond communication.
Efficient Induction of Hematopoietic Progenitor/Stem Cell Differentiation by Lentiviral Gene Transduction of TAL1/SCL Into Human ES Cells.
Authors: Ryo Kurita, Yoshie Miura, Michiyo Okada, Rui Kageyama, Takafumi Hiramoto, Tomoko Yokoo, Megumi Narusawa, Youko Suehiro, Hiroyuki Inoue, Tomotoshi Marumoto, Atsushi Takahashi, Kenzaburo Tani
Journal: Blood (2009)
PD-1 Is Not a Reliable Marker of Impending Relapse after Allogeneic Stem Cell Transplantation
Authors: Prachi Jain, Xin Tian, Jinguo Chen, Caroline R Cantilena, Christian Bradley, Reema Panjwani, Keyvan Keyvanfar, Fariba Chinian, Eleftheria Koklanaris, Jeanine Superata, Sara Hauffe, Minoo Battiwalla, A John Barrett, Sawa Ito
Journal: Blood (2017)
Bifurcation angle is an independent predictor of outcome after crush stenting of coronary bifurcation lesions
Authors: V Dzavik, P Daly, D Ing, E Horlick, R Kharbanda, A Barolet, S Bui, K Mackie, J Ross, L Schwartz, P H Seidelin
Journal: Journal of the American College of Cardiology (2006)
Abstract 18234: miR-362-3p Decreases hERG Expression and is Associated With an Unidentified Form of Congenital Long-QT Syndrome
Authors: Minghai Shao, Rongrong Wei, James E Tisdale, Wanqing Liu, Brian R Overholser
Journal: Circulation (2013)

Introduction: Endogenous microRNAs (miRs) regulate cardiovascular disease by modulating diverse cellular processes. We recently discovered that miRs may mediate the association between a single nucleotide polymorphism (rs1533317) and QT interval prolongation; identified in a previous genome-wide association study (GWAS). The objective of this research was to assess the ability of the identified miRs to regulate the expression of hERG (i.e. KCNH2). Methods: Through a previous genome-wide integrated miR-transcriptome analysis, the expression of 9 miRs were significantly associated with rs1533317 (p&lt; 1x10 -5 ). To assess this relationship further, a correlation analyses between transcriptome and miRNome data was performed related to the down-regulation of KCNH2. The potential targeting of KCNH2 by miR was validated using a Dual-Luciferase Assay of the KCNH2 3′-UTR. SK-Br-3 cells were co-transfected with miR mimic or negative control and the KCNH2-3’UTR reporter clone. The reporter plasmid, renilla, was used to control for transfection efficiency. To further assess the ability of miRs to down-regulate KCNH2, SK-Br-3 cells (endogenous KCNH2 expression) were transfected with miR mimic or control and KCNH2 protein expression was assessed by Western blot analysis. Results: Out of the 9 assessed, miRs 362-3p, 98, 148, 129*, and 186 were significantly associated with down-regulation of KCNH2 based on the transcriptome and miRNome data (p&lt;0.001). From the Luciferase assay, miR-362-3p was the only miR to significantly reduce KCNH2 3’UTR activity (mean ± SE of 42.6% ± 16.9) relative to control, whereas KCNH2 3’UTR activity was enhanced by miR-98 by an unknown mechanism (figure). Endogenous KCNH2 protein expression was reduced by 33.9% ± 5.3 relative to GAPDH by miR 362-3p (p=0.01). Conclusion: Upregulation of miR-362-3p decreases KCNH2 expression and may be the underlying mechanism for a previously reported unidentified form of LQTS regulated by rs1533317.
Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells
Authors: Szu-Han Huang, Yanqin Ren, Allison S. Thomas, Dora Chan, Stefanie Mueller, Adam R. Ward, Shabnum Patel, Catherine M. Bollard, Conrad Russell Cruz, Sara Karandish, Ronald Truong, Amanda B. Macedo, Alberto Bosque, Colin Kovacs, Erika Benko, Alicja Piechocka-Trocha, Hing Wong, Emily Jeng, Douglas F. Nixon, Ya-Chi Ho, Robert F. Siliciano, Bruce D. Walker, R. Brad Jones
Journal: Journal of Clinical Investigation (2018)

The presence of persistent, latent HIV reservoirs in CD4+ T cells obstructs current efforts to cure infection. The so-called kick-and-kill paradigm proposes to purge these reservoirs by combining latency-reversing agents with immune effectors such as cytotoxic T lymphocytes. Support for this approach is largely based on success in latency models, which do not fully reflect the makeup of latent reservoirs in individuals on long-term antiretroviral therapy (ART). Recent studies have shown that CD8+ T cells have the potential to recognize defective proviruses, which comprise the vast majority of all infected cells, and that the proviral landscape can be shaped over time due to in vivo clonal expansion of infected CD4+ T cells. Here, we have shown that treating CD4+ T cells from ART-treated individuals with combinations of potent latency-reversing agents and autologous CD8+ T cells consistently reduced cell-associated HIV DNA, but failed to deplete replication-competent virus. These CD8+ T cells recognized and potently eliminated CD4+ T cells that were newly infected with autologous reservoir virus, ruling out a role for both immune escape and CD8+ T cell dysfunction. Thus, our results suggest that cells harboring replication-competent HIV possess an inherent resistance to CD8+ T cells that may need to be addressed to cure infection.
Dieulafoy’s disease with mediastinal arteriovenous malformation
Authors: Andrea Zhi Xin Foo, Anne Ann Ling Hsu
Journal: Thorax (2018)

A 42-year-old, non-smoker man was hospitalised for newly diagnosed acute myeloid leukaemia and had an episode of haemoptysis of 200 mL fresh blood, complicated by transient hypotension. Patient was afebrile and his blood results were: haemoglobin 10.0 g/dL decreasing to 8.5 g/dL within 1 day of haemoptysis, total white cell counts 23x109/L, platelet counts 30x109/L, normal renal panel and coagulation profile. CT scan reported extensive tortuous mediastinal vessels (figure 1A). Flexible bronchoscopy under platelet transfusion revealed a small lesion in the right upper lobe (RUL) bronchus (figure 2). Upon contact of the bronchoscope tip with the lesion, brisk bleeding occurred (online supplementary video) which ceased with ice-cold saline wash. A diagnosis of Dieulafoy’s disease associated with mediastinal arteriovenous malformation (AVM) was made. CT angiogram followed by embolisation of major vessels feeding into RUL (figures 1B …
Guidelines, policies, and barriers to kidney care: findings from a global survey
Authors: Meaghan Lunney, Mona Alrukhaimi, Gloria E. Ashuntantang, Aminu K. Bello, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Vivekanand Jha, David W. Johnson, Kamyar Kalantar-Zadeh, Rumeyza Kazancioglu, Michelle E. Olah, Timothy Olusegun Olanrewaju, Mohamed A. Osman, Yasin Parpia, Jeffrey Perl, Harun Ur Rashid, Ahmed Rateb, Eric Rondeau, Laura Sola, Irma Tchokhonelidze, Marcello Tonelli, Natasha Wiebe, Isaac Wirzba, Chih-Wei Yang, Feng Ye, Alexander Zemchenkov, Ming-hui Zhao, Adeera Levin
Journal: Kidney International Supplements (2018)
The chloroethylnitrosourea, BCNU, activates the ATR-Chk1 pathway in medulloblastomas independent of the DNA mismatch repair pathway
Authors: Bo Cui, Stewart Johnson, Francis Ali-Osman, Darell Bigner, Henry Friedman
Journal: Cancer Research (2007)

1069  The chloroethylnitrosoureas are an important class of antitumor agents whose cytotoxicity is believed to be largely a result of the DNA interstrand cross-links that are formed subsequent to their reaction with cellular DNA. One of these agents, 1,3-bis(2-chloroethyl)-1-nitrosouear (BCNU), has been commonly used in adjunct therapy of brain tumors. Though its mechanisms of action have been well defined, the DNA damage response pathway to BCNU remains unelucidated. Human checkpoint kinase 1 (Chk1) is a major effector of normal S-phase progression and is involved in the G2/M-phase checkpoint signaling in response to genotoxic stress. In response to DNA damage, Chk1 is phosphorylated by ATR, a member of the phosphatidyalinositol-3-kinase-related kinase (PIKK) family. We hypothesized that DNA damage response to BCNU involved the ATR-Chk1 pathway as BCNU-induced DNA interstrand cross-links pose a replication stress to the cell. In the current study, we exposed medulloblastoma cell lines (D341 MED, Daoy MED, D487 MED and D283 MED) to 2-20 μM BCNU and assessed the activation of the ATR-Chk1 pathway in these cells. We observed the activation of Chk1 as evidenced by phosphorylation of Chk1 at serine 345 as early as 4 hours after treatment of the cells with BCNU with a peak occurring between 16 and 24 hours. Inhibition of the ATR kinase activity can be effected by treatment with caffeine or wortmannin, which are broad spectrum inhibitors of the PIKKs. These inhibitors were found to reduce substantially the phosphorylation of Chk1. Small interfering RNA knockdown of ATR also decreased the level of Chk1 phosphorylation, indicating a specific requirement for ATR in Chk1 activation. Other investigators have found that Chk1 activation by ATR in response to DNA damage is dependent upon a functional DNA mismatch repair apparatus. However, two of these medulloblastoma cell lines (D283 MED and D341 MED) are deficient in DNA mismatch repair, specifically lacking the MutLα protein. This result suggests that activation of the ATR-Chk1 pathway in response to the DNA damage induced by BCNU is independent of the DNA mismatch repair pathway.
Overexpression of a constitutively-active cGMP-independent protein kinase mutant reduces neointima formation following balloon-injury in rat carotid arteries via an antiproliferative and antimigratory effect
Authors: Peter Sinnaeve, H Gillijns, N Van Peit, JD Chiche, Desire Collen, K Bloch, Stefan Janssens
Journal: Circulation (1999)
Mexicans head off spread of zoonotic tuberculosis
Authors: Jacqui Thornton
Journal: BMJ (2018)

The Union/Steve Forrest/Workers’ Photos

The still twitching heads of 50 slaughtered cows in five rows of 10 are being inspected by vets, distinguishable from the slaughtermen by their orange hard hats, in the Zapopan municipal slaughterhouse in Jalisco state, Mexico.

The vets are searching for signs of calcified lesions that indicate bovine tuberculosis. Each part of the body is marked in turquoise with …
Justify your alpha
Authors: Daniel Lakens, Federico G. Adolfi, Casper J. Albers, Farid Anvari, Matthew A. J. Apps, Shlomo E. Argamon, Thom Baguley, Raymond B. Becker, Stephen D. Benning, Daniel E. Bradford, Erin M. Buchanan, Aaron R. Caldwell, Ben Van Calster, Rickard Carlsson, Sau-Chin Chen, Bryan Chung, Lincoln J. Colling, Gary S. Collins, Zander Crook, Emily S. Cross, Sameera Daniels, Henrik Danielsson, Lisa DeBruine, Daniel J. Dunleavy, Brian D. Earp, Michele I. Feist, Jason D. Ferrell, James G. Field, Nicholas W. Fox, Amanda Friesen, Caio Gomes, Monica Gonzalez-Marquez, James A. Grange, Andrew P. Grieve, Robert Guggenberger, James Grist, Anne-Laura van Harmelen, Fred Hasselman, Kevin D. Hochard, Mark R. Hoffarth, Nicholas P. Holmes, Michael Ingre, Peder M. Isager, Hanna K. Isotalus, Christer Johansson, Konrad Juszczyk, David A. Kenny, Ahmed A. Khalil, Barbara Konat, Junpeng Lao, Erik Gahner Larsen, Gerine M. A. Lodder, Jiří Lukavský, Christopher R. Madan, David Manheim, Stephen R. Martin, Andrea E. Martin, Deborah G. Mayo, Randy J. McCarthy, Kevin McConway, Colin McFarland, Amanda Q. X. Nio, Gustav Nilsonne, Cilene Lino de Oliveira, Jean-Jacques Orban de Xivry, Sam Parsons, Gerit Pfuhl, Kimberly A. Quinn, John J. Sakon, S. Adil Saribay, Iris K. Schneider, Manojkumar Selvaraju, Zsuzsika Sjoerds, Samuel G. Smith, Tim Smits, Jeffrey R. Spies, Vishnu Sreekumar, Crystal N. Steltenpohl, Neil Stenhouse, Wojciech Świątkowski, Miguel A. Vadillo, Marcel A. L. M. Van Assen, Matt N. Williams, Samantha E. Williams, Donald R. Williams, Tal Yarkoni, Ignazio Ziano, Rolf A. Zwaan
Journal: Nature Human Behaviour (2018)
Association of Depression With Mortality in Older Adults Undergoing Transcatheter or Surgical Aortic Valve Replacement
Authors: Laura M. Drudi, Matthew Ades, Sena Turkdogan, Caroline Huynh, Sandra Lauck, John G. Webb, Nicolo Piazza, Giuseppe Martucci, Yves Langlois, Louis P. Perrault, Anita W. Asgar, Marino Labinaz, Andre Lamy, Nicolas Noiseux, Mark D. Peterson, Rakesh C. Arora, Brian R. Lindman, Melissa Bendayan, Rita Mancini, Amanda Trnkus, Dae H. Kim, Jeffrey J. Popma, Jonathan Afilalo
Journal: JAMA Cardiology (2018)

Depression is increasingly recognized as a risk factor for adverse outcomes in cardiovascular disease. However, little is known about depression in older adults undergoing transcatheter (TAVR) or surgical (SAVR) aortic valve replacement.To determine the prevalence of depression and its association with all-cause mortality in older adults undergoing TAVR or SAVR.This preplanned analysis of the Frailty Aortic Valve Replacement (FRAILTY-AVR) prospective cohort study included 14 centers in 3 countries from November 15, 2011, through April 7, 2016. Individuals 70 years or older who underwent TAVR or SAVR were enrolled. Depressive symptoms were evaluated using the Geriatric Depression Scale Short Form at baseline and follow-up.All-cause mortality at 1 and 12 months after TAVR or SAVR. Logistic regression was used to determine the association of depression with mortality after adjusting for confounders such as frailty and cognitive impairment.Among 1035 older adults (427 men [41.3%] and 608 women [58.7%]) with a mean (SD) age of 81.4 (6.1) years, 326 (31.5%) had a positive result of screening for depression, whereas only 89 (8.6%) had depression documented in their clinical record. After adjusting for clinical and geriatric confounders, baseline depression was found to be associated with mortality at 1 month (odds ratio [OR], 2.20; 95% CI, 1.18-4.10) and at 12 months (OR, 1.532; 95% CI, 1.03-2.24). Persistent depression, defined as baseline depression that was still present 6 months after the procedure, was associated with a 3-fold increase in mortality at 12 months (OR, 2.98; 95% CI, 1.08-8.20).One in 3 older adults undergoing TAVR or SAVR had depressive symptoms at baseline and a higher risk of short-term and midterm mortality. Patients with persistent depressive symptoms at follow-up had the highest risk of mortality.
Conduct Disorder and Neighborhood Effects
Authors: Wesley G. Jennings, Nicholas M. Perez, Jennifer M. Reingle Gonzalez
Journal: Annual Review of Clinical Psychology (2018)

There has been a considerable amount of scholarly attention to the relationship between neighborhood effects and conduct disorder, particularly in recent years. Having said this, it has been nearly two decades since a comprehensive synthesis of this literature has been conducted. Relying on a detailed and comprehensive search strategy and inclusion criteria, this article offers a systematic and interdisciplinary review of 47 empirical studies that have examined neighborhood effects and conduct disorder. Described results suggest that there are generally robust linkages between adverse neighborhood factors and conduct disorder and externalizing behavior problems, as 67 of the 93 (72.04%) effect sizes derived from these studies yielded statistically significant neighborhood effects. The review also identifies salient mediating and moderating influences. It discusses study limitations and directions for future research as well.
“Direct to Drug” Screening As a Route to Individualized Therapy in Multiple Myeloma
Authors: Nathalie Meurice, Joachim L Petit, Cecilia Bonolo De Campos, Alysia N Polito, Ilsel D Lopez Armenta, Gregory J Ahmann, Laura Ann Bruins, Joseph R Mikhael, Craig B. Reeder, Angela A Mayo, P. Leif Bergsagel, Rafael Fonseca, Nikolai Sepetov, Sergei Romanov, A. Keith Stewart
Journal: Blood (2017)
Effect of Deferasirox Combined with Erythropoietin Versus Erythropoietin Alone on Erythroid Response in Patients with Low- and Int-1-Risk Myelodysplastic Syndromes: Results of the Phase II Kallisto Trial
Authors: Norbert Gattermann, Rosa Coll, Lutz Jacobasch, Allameddine Allameddine, Laurie DeBonnett, Amin Azmon, Jie Jin
Journal: Blood (2017)
Abstract P034: Hypertension in a Pediatric Cardiology Practice
Authors: Sara K Sexson Tejtel, Constance Cephus, Thomas Seery, America Suh, Douglas Moodie
Journal: Circulation (2016)

Background: Hypertension (HTN) is becoming a more recognized problem in pediatrics in general, though the prevalence is not changing despite the increasing prevalence of obesity.(1) The prevalence of borderline high and high blood pressure in children and adolescents appears to have plateaued at 11-12%. (1) Annual blood pressure measurement in patients being seen in pediatric practices has long been recommended. Our goal is to evaluate whether or not patients with HTN seen in a pediatric cardiology practice were appropriately diagnosed with HTN. Methods: A retrospective analysis of patients seen in the Texas Children’s Hospital Pediatric Cardiology outpatient clinics between 2005 and 2015 was performed. All blood pressure measurements, heights, weights, and BMI obtained at the same clinic visit were obtained from the electronic medical record. Patients with missing data were excluded from the analysis The data was analyzed using SAS with calculations performed of means, standard deviations and interquartile ranges. Chi-squre and t-tests were used to compare means. Results: A total of 57,670 patients (53% male, mean age 8.7 +/- 8.3) were seen in clinic. The average BMI was 19 (range 0 to 95). There were a total of 125,750 visits, with a average number of visits 3.9 (range 1-64). 33,765 patients had blood pressure measurements in the pre-HTN or HTN range and 9,149 patients had Stage 2 HTN measured at the time of clinic visit. Most children (35,220, 61%) had only one visit and were therefore unable to truly be diagnosed with HTN. Of the remaining 22,450 patients, 3,751 (15%) patients had hypertensive blood pressure measurements on at least three occasions and 977 (26%) of those were diagnosed with HTN. The diagnosis of HTN was made in younger patients (p&lt;0.001). Of those with the diagnosis of HTN, 691 (70%) were on antihypertensive medication. Younger patients were more likely to be treated for HTN than not, 10.3 +/- 11.7 years and 16.2 +/- 16.4 years respectively (p&lt;0.001). Additionally proportionally females were more likely to be diagnosed with (p&lt;0.001) and treated for HTN (p&lt;0.001) than males. Conclusions: HTN is a common problem in pediatrics. In a pediatric cardiology practice, many patients have HTN that is undiagnosed. If HTN is diagnosed it is frequently either untreated or inadequately treated. While evaluation of blood pressure is being performed and documented in most patients adequate diagnosis and treatment is lacking.