tbuckley/cabot-search huggingface dataset:
TCT-340 Anomalous connection of the right coronary artery with interarterial course: preliminary prospective experience of stenting in a selected adult population
Authors: Philippe Degrell, Xavier Halna du Fretay, Patrick Dupouy, Paul Barragan, Mohammed Nejjari, Christophe Dugauquier, Jean-Michel Juliard, Pierre Aubry
Journal: Journal of the American College of Cardiology (2017)
On nuclear weapons, McCartney paints a biased picture.
Authors: Gee Yen Shin
Journal: BMJ (2017)

McCartney makes the controversial claim that “even if the nuclear weapons are never used, they do harm.”1

The whole point of a strategic nuclear deterrent is to deter any enemy from considering a nuclear first strike, a strategy predicated on the concept of mutually assured destruction. The fact that no nuclear weapons have been used in anger since the end of …
Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project
Authors: Zorana J. Andersen, Massimo Stafoggia, Gudrun Weinmayr, Marie Pedersen, Claudia Galassi, Jeanette T. Jørgensen, Anna Oudin, Bertil Forsberg, David Olsson, Bente Oftedal, Gunn Marit Aasvang, Geir Aamodt, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Nancy L. Pedersen, Claes-Göran Östenson, Laura Fratiglioni, Kirsten T. Eriksen, Anne Tjønneland, Petra H. Peeters, Bas Bueno-de-Mesquita, Michelle Plusquin, Timothy J. Key, Andrea Jaensch, Gabriele Nagel, Alois Lang, Meng Wang, Ming-Yi Tsai, Agnes Fournier, Marie-Christine Boutron-Ruault, Laura Baglietto, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Enrica Migliore, Ibon Tamayo-Uria, Pilar Amiano, Miren Dorronsoro, Roel Vermeulen, Ranjeet Sokhi, Menno Keuken, Kees de Hoogh, Rob Beelen, Paolo Vineis, Giulia Cesaroni, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen
Journal: Environmental Health Perspectives (2017)

BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts -Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM)
PET Scans With <sup>18</sup>F-Fluorodeoxyglucose to Diagnose Adrenal Tumors
Authors: Brock O’Neil, William T. Lowrance, Marta E. Heilbrun
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms
Authors: Margaret Nieborowska-Skorska, Silvia Maifrede, Yashodhara Dasgupta, Katherine Sullivan, Sylwia Flis, Bac Viet Le, Martyna Solecka, Elizaveta A. Belyaeva, Lucia Kubovcakova, Morgan Nawrocki, Martin Kirschner, Huaqing Zhao, Josef T. Prchal, Katarzyna Piwocka, Alison R. Moliterno, Mariusz Wasik, Steffen Koschmieder, Tony R. Green, Radek C. Skoda, Tomasz Skorski
Journal: Blood (2017)
Neuropilin-1 associates with c-Met and modulates hepatocyte growth factor actions
Authors: Akira Matsushita, Tobias Gotze, Jason Gunn, Murray Korc
Journal: Cancer Research (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

410 

Pancreatic ductal adenocarcinoma (PDAC), a leading cause of cancer death, harbors several key genetic alterations and is characterized by the overexpression of multiple tyrosine kinase receptors and their ligands, including c-Met and its ligand hepatocyte growth factor (HGF). Neuropilin-1 (Np-1), a co-receptor for vascular endothelial growth factor (VEGF), does not have intrinsic signaling capabilities but is expressed at high levels in PDAC. In this study we sought to determine whether there is an interaction between Np-1 and c-Met.

Methods: COLO-357 pancreatic cancer cells, which express relatively low levels of Np-1, were stably transfected with the Np-1 cDNA. Invasion and signaling studies were then performed, localization was assessed by confocal microscopy and the role of c-Met was evaluated by siRNA-based strategies.

Results: Overexpression of Np-1 was associated with enhanced invasiveness of the cells across a Matrigel membrane in response to HGF, and these effects were abolished by siRNA-mediated down-regulation of c-Met. Immunoprecipitation studies revealed that Np-1 associated with c-Met but not with EGFR family members. By confocal microscopy, this association occurred on the plasma membrane, and HGF promoted the internalization of Np-1-c-Met complex. HGF greatly increased c-Met tyrosine phosphorylation and p-38 MAPK phosphorylation in Np-1 overexpressing clones by comparison with its effects in sham-transfected cells. SB203580, a p38 MAPK inhibitor, suppressed HGF-induced invasion in Np-1 overexpressing cells, whereas U0126, a MAPK inhibitor, was without effect. PP2 and LY294002, which inhibit Src and PI-3Kinase, respectively, also suppressed HGF-induced invasion in these cells. Conclusions: Np-1 is a co-receptor of c-Met that modulates HGF/c-Met signaling pathways; HGF promotes invasion via a p38 MAPK pathway that is also dependent on Src and PI-3Kinase; targeting Np-1 may lead to novel therapeutic strategies in PDAC.
Abstract 17400: Catecholamine Release Triggered by Epicardial Absolute Refractory Period Stimulation Augments Global Left Ventricular Function
Authors: Bruce R Ito, James W Covell, Guy P Curtis
Journal: Circulation (2015)

Background: Biventricular epicardial (Epi) pacing can augment left ventricular (LV) function in heart failure. We postulated that these beneficial effects could involve catecholamine release from local autonomic nerve activation. This hypothesis was tested by applying Epi pacing stimuli during the muscle’s absolute refractory period (ARP) thereby activating intrinsic nerves without altering activation sequence. Methods: Anesthetized farm pigs (n=5) were instrumented with a LV high-fidelity pressure transducer, left atrial and LV Epi pacing electrodes, and sonomicrometer segment length (SL) gauges placed proximal and distal to the LV stimulation site. A small catheter was placed into the great cardiac vein adjacent to the LV pacing site for blood sampling. During atrial pacing at constant rate, 3 electrical pulses (0.8ms, 2-3x threshold volts) were applied to the LV Epi electrodes during the ARP. An experimental run consisted of baseline measurements, with 10 minutes of stimulation followed by 5 minutes of recovery repeated 3 times before and with ß- receptor blockade (BB, metoprolol, 5 mg). Coronary venous blood was sampled at baseline and at 5 and 10 minutes of stimulation for norepinephrine analysis (NE by ELISA). Results: ARP stimulation produced a significant increase in coronary venous NE levels (p&lt; 0.01) accompanied by a significant 10-15% increase in LV dP/dt max (p&lt; 0.01). Segment length vs. LV pressure loop area proximal to the stimulus site was significantly decreased (29.8 ± 10.9 mmHg*mm) compared to baseline (92.6 ± 8.2 mmHg*mm) but was unchanged at the distal site. BB abolished the changes in segment function and blocked the increase in LV dP/dt despite continued NE release. Conclusion: These results demonstrate that ARP EPI pacing induces NE release and augments global LV function. This effect may contribute to the beneficial effect of biventricular Epi pacing in some patients with heart failure.
Physiology of Heat Regulation and the Science of Clothing:
Journal: Annals of Internal Medicine (1950)

anticoagulants; neither seems to be pertinent to the text, but both are useful adjuncts.Each chapter has a complete bibliography which adds con- siderably to the value of the book.The variety of subjects discussed necessitates a rather brief discussion of each one, but the author has succeeded rather well in emphasizing the important phases of each subject.The radiologic illustrations are very good; the only suggestion for future editions would be to increase the size of the figures for clarity.This comprehensive monograph should be well received by the physician interested in diseases of the aorta.
The Future of Radiobiology
Authors: David G Kirsch, Max Diehn, Aparna H Kesarwala, Amit Maity, Meredith A Morgan, Julie K Schwarz, Robert Bristow, Sandra Demaria, Iris Eke, Robert J Griffin, Daphne Haas-Kogan, Geoff S Higgins, Alec C Kimmelman, Randall J Kimple, Isabelle M Lombaert, Li Ma, Brian Marples, Frank Pajonk, Catherine C Park, Dörthe Schaue, Phuoc T. Tran, Henning Willers, Brad G. Wouters, Eric J Bernhard
Journal: JNCI Journal of the National Cancer Institute (2017)

Innovation and progress in radiation oncology depend on discovery and insights realized through research in radiation biology. Radiobiology research has led to fundamental scientific insights, from the discovery of stem/progenitor cells to the definition of signal transduction pathways activated by ionizing radiation that are now recognized as integral to the DNA damage response (DDR). Radiobiological discoveries are guiding clinical trials that test radiation therapy combined with inhibitors of the DDR kinases DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM), ataxia telangiectasia related (ATR), and immune or cell cycle checkpoint inhibitors. To maintain scientific and clinical relevance, the field of radiation biology must overcome challenges in research workforce, training, and funding. The National Cancer Institute convened a workshop to discuss the role of radiobiology research and radiation biologists in the future scientific enterprise. Here, we review the discussions of current radiation oncology research approaches and areas of scientific focus considered important for rapid progress in radiation sciences and the continued contribution of radiobiology to radiation oncology and the broader biomedical research community.
WJOG6510G: Randomized phase II of Pmab + IRI vs Cmab + IRI for KRAS WT mCRC previously treated after FU, IRI, and L-OHP
Authors: Hiroki Hara, Daisuke Sakai, Toshimi Takano, Katsunori Shinozaki, Masahiro Goto, Hiroya Taniguchi, Junji Kishimoto, Narikazu Boku, Ichinosuke Hyodo, Kei Muro
Journal: Annals of Oncology (2017)
Introducing the new Evidence-Based Dermatology section
Authors: C. Flohr, K. Abuabara, F. Bath-Hextall, A. Nast, E. van Zuuren
Journal: British Journal of Dermatology (2017)

Linked Articles: Garcia-Doval et al. Br J Dermatol 2017; 177: 888–889. Callander et al. Br J Dermatol 2017; 177: 1007–1013.
H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas
Authors: Manav Pathania, Nicolas De Jay, Nicola Maestro, Ashot S. Harutyunyan, Justyna Nitarska, Pirasteh Pahlavan, Stephen Henderson, Leonie G. Mikael, Angela Richard-Londt, Ying Zhang, Joana R. Costa, Steven Hébert, Sima Khazaei, Nisreen Samir Ibrahim, Javier Herrero, Antonella Riccio, Steffen Albrecht, Robin Ketteler, Sebastian Brandner, Claudia L. Kleinman, Nada Jabado, Paolo Salomoni
Journal: Cancer Cell (2017)
Concentration of Potentially Preventable Spending Among High-Cost Medicare Subpopulations
Authors: Jose F. Figueroa, Karen E. Joynt Maddox, Nancy Beaulieu, Robert C. Wild, Ashish K. Jha
Journal: Annals of Internal Medicine (2017)

Background: Little is known about whether potentially preventable spending is concentrated among a subset of high-cost Medicare beneficiaries. Objective: To determine the proportion of total spending that is potentially preventable across distinct subpopulations of high-cost Medicare beneficiaries. Design: Beneficiaries in the highest 10% of total standardized individual spending were defined as "high-cost" patients, using a 20% sample of Medicare fee-for-service claims from 2012. The following 6 subpopulations were defined using a claims-based algorithm: nonelderly disabled, frail elderly, major complex chronic, minor complex chronic, simple chronic, and relatively healthy. Potentially preventable spending was calculated by summing costs for avoidable emergency department visits using the Billings algorithm plus inpatient and associated 30-day postacute costs for ambulatory care–sensitive conditions (ACSCs). The amount and proportion of potentially preventable spending were then compared across the high-cost subpopulations and by individual ACSCs. Setting: Medicare. Participants: 6 112 450 Medicare beneficiaries. Measurements: Proportion of spending deemed potentially preventable. Results: In 2012, 4.8% of Medicare spending was potentially preventable, of which 73.8% was incurred by high-cost patients. Despite making up only 4% of the Medicare population, high-cost frail elderly persons accounted for 43.9% of total potentially preventable spending ($6593 per person). High-cost nonelderly disabled persons accounted for 14.8% of potentially preventable spending ($3421 per person) and the major complex chronic group for 11.2% ($3327 per person). Frail elderly persons accounted for most spending related to admissions for urinary tract infections, dehydration, heart failure, and bacterial pneumonia. Limitation: Potential misclassification in the identification of preventable spending and lack of detailed clinical data in administrative claims. Conclusion: Potentially preventable spending varied across Medicare subpopulations, with the majority concentrated among frail elderly persons. Primary Funding Source: The Commonwealth Fund.
Epidemiology of imaging-detected bone stress injuries in athletes participating in the Rio de Janeiro 2016 Summer Olympics
Authors: Daichi Hayashi, Mohamed Jarraya, Lars Engebretsen, Michel D Crema, Frank W Roemer, Abdalla Skaf, Ali Guermazi
Journal: British Journal of Sports Medicine (2017)

Bone stress injuries are common in high-level athletics.To describe the demographics, frequency and anatomical location of stress injuries (ie, stress reaction and stress fractures) in athletes at the Rio de Janeiro 2016 Summer Olympic Games.We recorded all sports injuries at the Rio de Janeiro 2016 Summer Olympics reported by the National Olympic Committee (NOC) medical teams and in the polyclinic and medical venues. Imaging was performed through the official IOC clinic within the Olympic Village, using digital X-ray cameras and 3T and 1.5T magnetic resonance (MR) scanners. Images were read centrally and retrospectively by musculoskeletal radiologists with expertise in sports injuries.11 274 athletes (5089 women (45%), 6185 men (55%)) from 207 NOCs participated in the study. 1101 injuries were reported. Imaging revealed 9 stress fractures (36%) and 16 stress reactions (64%) in 18 female and 7 male athletes (median age 25 years, age range 18-32). Stress injuries were mostly in the lower extremities (84%), particularly tibia (44%) and metatarsals (12%), with two in the lumbar spine (8%). Stress injuries were most common in track and field athletes (44%) followed by volleyball players (16%), gymnastics (artistic) (12%) and other type of sports.Twenty-five bone stress injuries were reported, more commonly in women, mostly in the lower extremities and most commonly in track and field athletes. Our study demonstrates the importance of early imaging with MRI to detect stress reactions before they can progress to stress fractures.
Abstract 15560: Inhibition of the Microrna Let-7 Enhances Epithelial-Mesenchymal Transition and Recruitment of Epicardial Cells After Acute Myocardial Infarction
Authors: Timon Seeger, Quanfu Xu, Marion Muhly-Reinholz, Ariane Fischer, Andreas M. Zeiher, Stefanie Dimmeler
Journal: Circulation (2013)

Intrinsic regeneration of the myocardium after acute myocardial infarction (AMI) is limited. The miRNA let-7 is involved in epithelial-mesenchymal transition (EMT) as well as differentiation proces...
Introduction to the Theme “New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development”
Authors: Paul A. Insel, Susan G. Amara, Terrence F. Blaschke, Urs A. Meyer
Journal: The Annual Review of Pharmacology and Toxicology (2017)

The theme “New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development” links 13 articles in this volume of the Annual Review of Pharmacology and Toxicology (ARPT). The engaging prefatory articles by Arthur Cho and Robert Lefkowitz set the stage for this theme and for the reviews that insightfully describe new approaches that advance research and discovery in pharmacology and toxicology. Examples include the progress being made in developing Organs-on-Chips/microphysiological systems and human induced pluripotent stem cell–derived cells to aid in understanding cell and tissue pharmacokinetics, action, and toxicity; the recognition of the importance of circadian rhythm, the microbiome, and epigenetics in drug and toxicant responses; and the application of results from new types of patient-derived information to create personalized/precision medicine, including therapeutics for pain, which may perhaps provide help in dealing with the opioid epidemic in the United States. Such new information energizes discovery efforts in pharmacology and toxicology that seek to improve the efficacy and safety of drugs in patients and to minimize the consequences of exposure to toxins.
Retrospective multicenter cohort of nab-paclitaxel plus gemcitabine (NG) after FOLFIRINOX failure in advanced pancreatic cancer (APC): Effectiveness, tolerability, and response markers.
Authors: Ines Vendrell, Arlindo Rebelo Ferreira, Catarina Pulido, Anuraj Parmanande, Filipa Ferreira Da Silva, João Vasco Barreira, João Godinho, João Moreira Pinto, Joaquim Gago, Nuno Couto, Ana Castro, Carlos Carvalho, José Passos-Coelho, Monica Semedo, Conceição Pinto, Luis Costa
Journal: Journal of Clinical Oncology (2017)

e15743 Background: NG is a standard 1 st line treatment for APC. Although recommended in 2 nd line after FOLFIRINOX, there is little evidence of its efficacy, tolerability and of markers of efficacy. Methods: We performed a multicenter retrospective cohort study, including patients (pts) with APC from 5 centers in Portugal treated with 2 nd line NG after 1 st line FOLFIRINOX from 01/2013-12/2016. We collected demographic, clinicopathological characteristics and treatment data. We used descriptive statistics, Kaplan-Meier methods and Cox proportional hazards analysis. Results: 30 pts were included; median age was 64 years (range 45–78); the majority had stage IV (90%) disease, an ECOG Performance Status of 0 (76.7%) and had received a median of 8.5 cycles of FOLFIRINOX (range 1–18). A median of 6 cycles of NG were administered (range 1–13). Median progression free survival (PFS) and overall survival (OS) were 6.4 months (CI 95% 3.0-8.5) and 11.4 months (CI 95% 8.4–16.5), respectively, and did not differ by age &lt; 65 or ≥65 (p = 0.87; p = 0.57 respectively). The most frequent toxicity was fatigue (66.6%, any grade). Grade 3-4 events occurred in 40% of pts – thrombocytopenia in 16.7%, neutropenia in 10.0%; anemia, sensorial neuropathy, fatigue and diarrhea each occurred in 3.3% of patients. No febrile neutropenia events or toxic deaths occurred. Median CA 19.9 at the beginning of NG was 1254U/mL (IQR: 207–6775); the median decrease of CA19.9 at 3 months was 45U/mL (IQR:-1373– +174). CA 19.9 variation at 3 months did not correlate with PFS (p = 0.53) or OS (p = 0.09) in multivariate analysis (adjusted for age and stage at diagnosis). Neutrophil to Lymphocyte ratio (NLR) was high ( &gt; 3.0) in 37.5% of patients before 1 st line treatment and in 27.6% at the beginning of NG. In multivariate analysis NLR before 1 st or 2 nd chemotherapy lines were not associated with PFS (p = 0.39; p = 0.14 respectively) or OS (p = 0.44; p = 0.12, respectively). Conclusions: In this cohort of pts with APC, NG was an effective and well tolerated 2 nd line regimen after FOLFIRINOX failure, even in pts ≥65 years. Neither CA19.9 variation at 3 months nor NLR were markers of NG clinical benefit.
Authors’ reply to Baker and Alderson
Authors: Thomas J Cahill, Mark Dayer, Bernard Prendergast, Martin Thornhill
Journal: BMJ (2017)

Baker and Alderson emphasise elements of the available data to support the decision made by NICE to withdraw antibiotic prophylaxis for patients at risk of infective endocarditis in the UK.1 Differing interpretations of best practice in the context of limited data are the essence of the uncertainty that underlies The BMJ ’s article series and should be welcomed. As we outlined explicitly in our Uncertainties article,2 Baker and Alderson …
Association of the bevacizumab pharmacokinetics with efficacy and toxicity in advanced non-small cell lung cancer
Authors: Megumi Inaba, Sho Saeki, Jiichiro Sasaki, Shinya Sakata, Ryo Sato, Koichi Saruwatari, Hiroto Kishi, Shinji Fujii, Akinobu Hamada, Hirotsugu Kohrogi
Journal: Annals of Oncology (2017)
Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology
Authors: Thomas M. Gorter, Dirk J. van Veldhuisen, Johann Bauersachs, Barry A. Borlaug, Jelena Celutkiene, Andrew J.S. Coats, Marisa G. Crespo‐Leiro, Marco Guazzi, Veli‐Pekka Harjola, Stephane Heymans, Loreena Hill, Mitja Lainscak, Carolyn S.P. Lam, Lars H. Lund, Alexander R. Lyon, Alexandre Mebazaa, Christian Mueller, Walter J. Paulus, Burkert Pieske, Massimo F. Piepoli, Frank Ruschitzka, Frans H. Rutten, Petar M. Seferovic, Scott D. Solomon, Sanjiv J. Shah, Filippos Triposkiadis, Rolf Wachter, Carsten Tschöpe, Rudolf A. de Boer
Journal: European Journal of Heart Failure (2017)
TCT-418 Five Years Clinical Outcome of the Cobalt-Chromium Everolimus-Eluting Stent in Patients With Bare-Metal and Drug-Eluting In-Stent Restenosis
Authors: Takashi Hiromasa, Shoichi Kuramitsu, Hiroyuki Jinnouchi, Makoto Hyodo, Yoshimitsu Soga, Shinichi Shirai, Kenji Ando
Journal: Journal of the American College of Cardiology (2017)