tbuckley/cabot-search huggingface dataset:
UNIQUE CASE OF A TAKO-TSUBO CARDIOMYOPATHY OCCURRING IN A PATIENT WITH HEPATIC CIRRHOSIS SUBJECTED TO EVL
Authors: F Diterlizzi
Journal: Endoscopy (2018)

Variceal bleeding is a lethal complication of liver cirrhosis. Endoscopic variceal ligation is recommended as the first-choice intervention for esophageal variceal bleeding in cirrhotic patients. Vasoactive drugs play a role in controll variceal bleeding by reducing portal blood flow and portal pressure. Terlipressin is a synthetic analogue of natural hormone vasopressin with relatively low incidence of adverse effects.
COLON CAPSULE ENDOSCOPY AS SCREENING MODALITY FOR THR DETECTION OF COLORECTAL POLYPS
Authors: E Ivanova, E Tikhomirova, E Fedorov
Journal: Endoscopy (2018)

Colon capsule endoscopy (CCE) is an effective and painless diagnostic method for the examination of entire intestine and it is a reasonable way to diagnose diseases in screening patients. The aim of the study is to evaluate the significance of CCE in the detection of colorectal polyps in screening patients.
Left Ventricular Hypertrophy Patterns and Prognosis
Journal: Circulation (1974)

Electrocardiographic evidence of left ventricular hypertrophy (ECG-LVH), defined only by elevated R wave amplitudes in appropriate leads of the resting ECG, was ascertained among 2,760 survivors of myocardial infarction who had been randomized into the placebo-treated group of the Coronary Drug Project. The entry ECG findings were related to the subsequent three-year mortality. Of 2,760 men, 186 (6.7%) had ECG-LVH amplitude criteria in the baseline ECG when taken after at least three months survival (average, 36 months) from the last myocardial infarction. Three-year mortality in men with ECG-LVH was almost twice that in men without ECG-LVH (22.6% vs 12.1%; P = 0.0002) when the "effect" of all other variables on mortality was ignored. However, when the relationship between baseline ECG-LVH and subsequent mortality was adjusted, using a multivariate analysis, for other electrocardiographic and clinical findings, elevated R amplitude itself had no significantly independent prognostic importance. The prognostic importance of ECG-LVH was largely explained by coexisting repolarization abnormalities, although ECG-LVH plus abnormal ST-segment and T wave findings had a less favorable prognosis than ST-segment and T wave abnormalities alone. ECG-LVH by R wave amplitude criteria in the absence of abnormal ST-segment and T wave findings was unrelated to prognosis in these postinfarct patients.
QUALITY OF COLONOSCOPY IN CLUJ, ROMANIA
Authors: A Groza, C Tefas, O Mosteanu, M Tantau
Journal: Endoscopy (2018)

There is no screening programme for colorectal cancer (CRC) currently in Romania, but due to its growing incidence, different medical organizations are trying to implement one. In this respect we want to assess the current state of quality in colonoscopy in two of the largest Romanian Gastroenterology hospitals, in order to align certain aspects to the ESGE guidelines.
An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation
Authors: Teresa Song, Ana B. Pavel, Huei-Chi Wen, Kunal Malik, Yeriel Estrada, Juana Gonzalez, Peter W. Hashim, John K. Nia, Danielle Baum, Grace Kimmel, Giselle K. Singer, James G. Krueger, Emma Guttman-Yassky
Journal: Journal of Allergy and Clinical Immunology (2018)
Surgeon Attitudes Toward the Omission of Axillary Dissection in Early Breast Cancer
Authors: Monica Morrow, Reshma Jagsi, M. Chandler McLeod, Dean Shumway, Steven J. Katz
Journal: JAMA Oncology (2018)

The American College of Surgeons Oncology Group (ACOSOG) Z0011 study demonstrated the safety of sentinel node biopsy alone in clinically node-negative women with metastases in 1 or 2 sentinel nodes treated with breast conservation. Little is known about surgeon perspectives regarding when axillary lymph node dissection (ALND) can be omitted.To determine surgeon acceptance of ACOSOG Z0011 findings, identify characteristics associated with acceptance of ACOSOG Z0011 results, and examine the association between acceptance of the Society of Surgical Oncology and American Society for Radiation Oncology negative margin of no ink on tumor and surgeon preference for ALND.A survey was sent to 488 surgeons treating a population-based sample of women with early-stage breast cancer (N = 5080). The study was conducted from July 1, 2013, to August 31, 2015.Surgeons were categorized as having low, intermediate, or high propensity for ALND according to the outer quartiles of ALND scale distribution. A multivariable linear regression model was used to confirm independent associations.Of the 488 surgeons invited to participate, 376 (77.0%) responded and 359 provided complete information regarding propensity for ALND derived from 5 clinical scenarios. Mean surgeon age was 53.7 (range, 31-80) years; 277 (73.7%) were male; 142 (37.8%) treated 20 or fewer breast cancers annually and 108 (28.7%) treated more than 50. One hundred seventy-five (49.0%) recommended ALND for 1 macrometastasis. Of low-propensity surgeons who recommended ALND, only 1 (1.1%) approved ALND for any nodal metastases compared with 69 (38.6%) and 85 (95.5%) of selective and high-propensity surgeons (P < .001), respectively. In multivariable analysis, lower ALND propensity was significantly associated with higher breast cancer volume (21-50: -0.19; 95% CI, -0.39 to 0.02; >51: -0.48; 95% CI, -0.71 to -0.24; P < .001), recommendation of a minimal margin width (1-5 mm: -0.10; 95% CI, -0.43 to 0.22; no ink on tumor: -0.53; 95% CI, -0.82 to -0.24; P < .001), participation in a multidisciplinary tumor board (1%-9%: -0.25; 95% CI, -0.55 to 0.05; >9%: -0.37; 95% CI, -0.63 to -0.11; P = .02), and Los Angeles Surveillance, Epidemiology, and End Results site (-0.18; 95% CI, -0.35 to -0.01; P = .04).This study shows substantial variation in surgeon acceptance of more limited surgery for breast cancer, which is associated with higher breast cancer volume and multidisciplinary interactions, suggesting the potential for overtreatment of many patients and the need for education targeting lower-volume breast surgeons.
Drenaje biliar en patología de región biliopancreática maligna no resecable. papel del drenaje guiado por USE
Authors: M Puga, CF Consiglieri, J Busquets, N Peláez, L Secanella, B Lanquete, M Calvo, J Fabregat, J Castellote, JB Gornals
Journal: Endoscopy (2017)

El acceso transpapilar mediante CPRE es el procedimiento de elección de drenaje biliar en patología biliopancreática maligna irresecable. Durante los últimos años se ha incrementado el drenaje guiado por USE (DB-USE) en casos de CPRE fallida, incluso como estrategia de elección por algunos grupos (japoneses).
Synthesis and Ultrastructural Localization of Protein C Inhibitor in Human Platelets and Megakaryocytes
Authors: Maria J. Prendes, Edith Bielek, Margareta Zechmeister-Machhart, Erika Vanyek-Zavadil, Veronica A. Carroll, Johannes Breuss, Bernd R. Binder, Margarethe Geiger
Journal: Blood (1999)
High-Flow Nasal Cannula System
Authors: Michael A. Vella, Jose Pascual-Lopez, Lewis J. Kaplan
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
UNITED STATES ADOPTED NAMES (USAN)
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for Peripheral Artery Disease With Ankle-Brachial Index
Authors: Jill Jin
Journal: JAMA (2018)

US Preventive Services Task Force; Susan J. Curry, PhD; Alex H. Krist, MD, MPH; Douglas K. Owens, MD, MS; Michael J. Barry, MD; Aaron B. Caughey, MD, PhD; Karina W. Davidson, PhD, MASc; Chyke A. Doubeni, MD, MPH; John W. Epling Jr, MD, MSEd; Alex R. Kemper, MD, MPH, MS; Martha Kubik, PhD, RN; C. Seth Landefeld, MD; Carol M. Mangione, MD, MSPH; Michael Silverstein, MD, MPH; Melissa A. Simon, MD, MPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD
Trace Amines and Their Receptors
Authors: Raul R. Gainetdinov, Marius C. Hoener, Mark D. Berry
Journal: Pharmacological Reviews (2018)

Trace amines are endogenous compounds classically regarded as comprising β-phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites. They are also abundant in common foodstuffs and can be produced and degraded by the constitutive microbiota. The ability to use trace amines has arisen at least twice during evolution, with distinct receptor families present in invertebrates and vertebrates. The term "trace amine" was coined to reflect the low tissue levels in mammals; however, invertebrates have relatively high levels where they function like mammalian adrenergic systems, involved in "fight-or-flight" responses. Vertebrates express a family of receptors termed trace amine-associated receptors (TAARs). Humans possess six functional isoforms (TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9), whereas some fish species express over 100. With the exception of TAAR1, TAARs are expressed in olfactory epithelium neurons, where they detect diverse ethological signals including predators, spoiled food, migratory cues, and pheromones. Outside the olfactory system, TAAR1 is the most thoroughly studied and has both central and peripheral roles. In the brain, TAAR1 acts as a rheostat of dopaminergic, glutamatergic, and serotonergic neurotransmission and has been identified as a novel therapeutic target for schizophrenia, depression, and addiction. In the periphery, TAAR1 regulates nutrient-induced hormone secretion, suggesting its potential as a novel therapeutic target for diabetes and obesity. TAAR1 may also regulate immune responses by regulating leukocyte differentiation and activation. This article provides a comprehensive review of the current state of knowledge of the evolution, physiologic functions, pharmacology, molecular mechanisms, and therapeutic potential of trace amines and their receptors in vertebrates and invertebrates.
Tesla and the Violet Ray
Authors: Tyler Marion, Kevin Cao, Jorge Roman
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome
Authors: Didier Dulon, Samantha Papal, Pranav Patni, Matteo Cortese, Philippe F.Y. Vincent, Margot Tertrais, Alice Emptoz, Abdelaziz Tlili, Yohan Bouleau, Vincent Michel, Sedigheh Delmaghani, Alain Aghaie, Elise Pepermans, Olinda Alegria-Prevot, Omar Akil, Lawrence Lustig, Paul Avan, Saaid Safieddine, Christine Petit, Aziz El-Amraoui
Journal: Journal of Clinical Investigation (2018)

Clarin-1, a tetraspan-like membrane protein defective in Usher syndrome type IIIA (USH3A), is essential for hair bundle morphogenesis in auditory hair cells. We report a new synaptic role for clarin-1 in mouse auditory hair cells elucidated by characterization of Clrn1 total (Clrn1ex4–/–) and postnatal hair cell–specific conditional (Clrn1ex4fl/fl Myo15-Cre+/–) knockout mice. Clrn1ex4–/– mice were profoundly deaf, whereas Clrn1ex4fl/fl Myo15-Cre+/– mice displayed progressive increases in hearing thresholds, with, initially, normal otoacoustic emissions and hair bundle morphology. Inner hair cell (IHC) patch-clamp recordings for the 2 mutant mice revealed defective exocytosis and a disorganization of synaptic F-actin and CaV1.3 Ca2+ channels, indicative of a synaptopathy. Postsynaptic defects were also observed, with an abnormally broad distribution of AMPA receptors associated with a loss of afferent dendrites and defective electrically evoked auditory brainstem responses. Protein-protein interaction assays revealed interactions between clarin-1 and the synaptic CaV1.3 Ca2+ channel complex via the Cavβ2 auxiliary subunit and the PDZ domain–containing protein harmonin (defective in Usher syndrome type IC). Cochlear gene therapy in vivo, through adeno-associated virus–mediated Clrn1 transfer into hair cells, prevented the synaptic defects and durably improved hearing in Clrn1ex4fl/fl Myo15-Cre+/– mice. Our results identify clarin-1 as a key organizer of IHC ribbon synapses, and suggest new treatment possibilities for USH3A patients.
Prevalence and Variation of Developmental Screening and Surveillance in Early Childhood
Authors: Ashley H. Hirai, Michael D. Kogan, Veni Kandasamy, Colleen Reuland, Christina Bethell
Journal: JAMA Pediatrics (2018)

Since 2001, the American Academy of Pediatrics has recommended universal developmental screening and surveillance to promote early diagnosis and intervention and to improve the outcomes of children with developmental delays and disabilities.To examine the current prevalence and variation of developmental screening and surveillance of children by various sociodemographic, enabling, and health characteristics.This cross-sectional analysis of the Health Resources and Services Administration's 2016 National Survey of Children's Health-a nationally representative survey of US children completed between June 2016 and February 2017-examined 5668 randomly selected children 9 through 35 months of age whose parent or caregiver responded to the address-based survey by mail or via a website. All analyses were weighted to account for the probability of selection and nonresponse and to reflect population counts of all noninstitutionalized US children residing in housing units.Developmental screening was measured through a validated set of 3 items indicating receipt in the past year of parent-completed screening from a health care professional with age-appropriate content regarding language development and social behavior. Surveillance was determined by an item capturing verbal elicitation of developmental concerns by a health care professional.Of the estimated 9.0 million children aged 9 through 35 months, an estimated 30.4% (95% CI, 28.0%-33.0%) were reported by their parent or guardian to have received a parent-completed developmental screening and 37.1% (95% CI, 34.4%-39.8%) were reported to have received developmental surveillance from a health care professional in the past year. Characteristics associated with screening and/or surveillance that remained significant after adjustment included primary household language, family structure, household education, income, medical home, past-year preventive visit, child health status, and special health care needs. Having health care that meets medical home criteria was significantly associated with both developmental screening (adjusted rate ratio, 1.34; 95% CI, 1.13-1.57) and surveillance (adjusted rate ratio, 1.24; 95% CI, 1.08-1.42), representing an 8 to 9 absolute percentage point increase. State-level differences spanned 40 percentage points for screening (17.2% in Mississippi and 58.8% in Oregon) and surveillance (19.1% in Mississippi and 60.8% in Oregon), with approximately 90% of variation not explained by child and family characteristics.Despite more than a decade of initiatives, rates of developmental screening and surveillance remain low. However, state-level variation indicates continued potential for improvement. Systems-level quality improvement efforts, building on the medical home, will be necessary to achieve recommended screening and surveillance goals.
I-SCAN OPTICAL ENHANCEMENT FOR THE IN VIVO PREDICTION OF DIMINUTIVE COLORECTAL POLYP HISTOLOGY: RESULTS FROM A PROSPECTIVE THREE-PHASED MULTICENTRE TRIAL
Authors: E Klenske, S Zopf, C Neufert, A Naegel, J Siebler, J Gschossmann, S Mühldorfer, L Pfeifer, S Fischer, F Vitali, M Iacucci, S Ghosh, P Klare, GE Tontini, MF Neurath, T Rath
Journal: Endoscopy (2018)

Recently dye-less chromoendoscopy techniques have been emerging for diminutive colorectal polyp characterization. Herein, we investigated whether the newly introduced I-scan optical enhancement (OE) can accurately predict polyp histology in vivo in real time.
Baja incidencia de pancreatitis post-CPRE en un hospital de tercer nivel
Authors: AJ Del Pozo García, F Sánchez Gómez, JC Marín Gabriel, S Sáenz López, T Valdés, G Castellano Tortajada
Journal: Endoscopy (2017)

La pancreatitis aguda es la complicación más temida de la CPRE. Diversas estrategias, como stent pancreático profilático o AINES rectales, minorizan su riesgo pero no han conseguido disminuir el riesgo a cero.
Utilidad de las prótesis biliares metálicas autoexpandibles cubiertas en el tratamiento de la hemorragia intra y post-CPRE
Authors: A Conthe, C Martínez-Flores, S García-Mulas, L Rayón, O Nogales, B Merino, J García-Lledó, L Pérez-Carazo, M López-Ibáñez, R Bañares
Journal: Endoscopy (2017)

La hemorragia post-CPRE es una complicación con morbimortalidad elevada. La colocación temporal de prótesis biliares metálicas autoexpandibles cubiertas (PBMAC) se ha utilizado como terapia de rescate en esta complicación.
Modulation of tumor microenvironment enhances oncolytic virus therapy
Authors: Kazuhiko Kurozumi, Jayson Hardcastle, Ming Yang, Gregory Christoforidis, William Carson, E. Antonio Chiocca, Balveen Kaur
Journal: Cancer Research (2007)

4183  Like most solid tumors, glioblastoma multiforme is a complex tissue consisting of neoplastic, stromal, endothelial, and pericytic cells embedded in a complex extracellular matrix. The complex interplay between cancer cells and their microenvironment is crucial in determining the fate of a tumor and its response to treatment. Treatment of tumors mediated by oncolytic viruses (OV) employs a strategy based on initial infection of cancer cells by virus followed by replication and burst of virus infection resulting in tumor cell specific lysis. Detailed elucidation of the response of tumor environment to therapy with OV has been neglected. Vasculature is a major determinant of the microenvironment of malignant gliomas. We are using a syngeneic rat glioma model treated with an experimental herpes simplex virus (HSV)-derived OV to evaluate the response of tumor vessels to this treatment strategy. Our results have indicated a four-fold increase in vascular leakage upon infection with OV compared to injection with PBS (control). This observation was confirmed on ultra-high-field, high-resolution magnetic resonance (MR) imaging performed at 8.0-Tesla using gradient echo sequence enhanced by ultra-small particles of iron oxide (USPIO). Analysis of OV-induced changes in gene expression revealed significant induction of iNOS but not of VEGF, suggesting that increased vessel permeability could be the result of endothelial cell activation in response to inflammation induced by OV infection of tumor. We further show that this hyperpermeability is a result of endothelial cell activation caused by tumor inflammation in response to OV infection. Recent studies have revealed that rapid viral clearance mediated by innate host inflammatory responses limits OV therapy. Finally, we show that vascular normalization achieved by pretreatment with a single dose of cyclic RGD peptide (cRGD; a known anti-angiogenic agent and antagonist of integrins αvβ3, and αvβ5) suppressed OV-induced vascular leakage, suppressed CD45-positive leucocyte infiltration in tumor tissue, and significantly increased OV propagation and survival of rats with brain tumors (P = 0.0003 between OV and cRGD + OV). In conclusion, vascular normalization achieved prior to OV infection enhanced the therapeutic efficacy of OV.
Cancer-associated thrombosis in patients with implanted ports: a prospective multicenter French cohort study (ONCOCIP)
Authors: Hervé Decousus, Aurélie Bourmaud, Pierre Fournel, Laurent Bertoletti, Carine Labruyère, Emilie Presles, Adel Merah, Silvy Laporte, Laetitia Stefani, Francesco Del Piano, Jean-Philippe Jacquin, Guy Meyer, Franck Chauvin
Journal: Blood (2018)
TIP-IN ENDOSCOPIC MUCOSAL RESECTION VERSUS ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EN BLOC RESECTION IN LARGE COLORECTAL TUMORS
Authors: BM Ko, HJ Goong, SR Jeon, YH Jung, HG Kim, SJ Hong, JO Kim, MS Lee
Journal: Endoscopy (2018)

En bloc resection of large colorectal tumors by conventional endoscopic mucosal resection (EMR) is usually not possible since it is difficult to capture properly and piecemeal EMR accompanies high risk of recurrence. Although endoscopic submucosal dissection (ESD) is a good treatment option for en bloc resection in large colorectal tumors, it is generally time-consuming and technically challenging. The aim of this study was to investigate the feasibility of Tip-in EMR for en bloc resection in large colorectal tumors compared with ESD.