tbuckley/cabot-search huggingface dataset:
Priapism in Lymphoma
Authors: Ivan P. Law
Journal: JAMA (1974)

To the Editor.—  Priapism in hematologic malignancy has usually been associated with chronic myelocytic leukemia, 1 also rarely with acute leukemia, 2 and has been documented as a local circulatory phenomenon in the dorsal vein of the penis. Vadakan and Ortega 3 reported a case of acute lymphoblastic leukemia in which priapism developed, associated with central nervous system involvement. We have recently observed a similar finding in a patient with undifferentiated lymphoma.  Report of a Case.—  A 20-year-old white man was transferred here with a diagnosis of undifferentiated lymphoma. Physical findings included generalized lymphadenopathy and bilateral basilar rales, while the cardiovascular system was normal. The liver was enlarged 4 cm below the right costal margin. The spleen was not palpable. There was a palpable midline abdominal tumor mass. The laboratory studies showed the following values: white blood cells, 4,900/cu/mm; hematocrit, 32%; platelets, 315,000/cu mm; blood urea nitrogen, 27 mg/100 ml; and
Pain: Its Experimental Investigation
Authors: Robert Smith
Journal: Journal of the Royal Society of Medicine (1967)

Dr Robert Smith discusses the relationship between pain and emotional disturbance and describes experiments which he has undertaken in general practice, using a pressure algometer. Amongst other findings, he shows that aspirin did not relieve pressure pain but did delay or even suppress the onset of ultraviolet light burns.

Dr K D Keele describes experiments to define individual pain thresholds and correlates these with the pain of cardiac infarction, and the morphine requirements in that condition.

Professor C A Keele considers the chemistry of pain production and describes his technique for applying chemical algogens to experimentally induced blisters. He further considers the similarity between such substances and those contained in animal and plant venoms and speculates as to an even closer relationship between these and painful medical conditions.
RECOVERY FROM BROKEN NECK.
Authors: ARTHUR AYER LAW
Journal: JAMA (1907)

This case is of interest, not because a broken neck is especially rare, nor is recovery with partial restoration of function very unusual, but complete recovery following operative interference from fracture through the cervical vertebræ is almost unprecedented. I use the term broken neck advisedly—the conclusions of practically all observers have been that a dislocation of the cervical vertebræ without some fracture is impossible. If we are familiar with the bony contour of the vertebræ, with their articular processes placed nearly vertical, we readily understand how a dislocation without a fracture of greater or less magnitude is impossible. Medical literature contains report of a number of cases of fracture of the cervical vertebræ sh wing partial recovery with persistent deform y of the neck, greater or less pressure on spinal cord, possible paralysis, bed sores, etc., but I have been able to find but three cases where there was complete
Commentary: Having too much evidence (depression, suicide, and low serum cholesterol)
Authors: M. Law
Journal: BMJ (1996)

CONCLUSIONWe found that low or declining serum cholesterol concentrations were associated with death from suicide.Mechanisms that might link cholesterol concentrations to suicide should be thoroughly studied.The Paris prospective study I is organised by the Groupe d'Etude sur l'Epidemiologie de l'Atherosclerose.We thank Annie Bingham for technical assistance with the
Dynamic Studies of Metabolic Bone Disease.
Journal: Annals of Internal Medicine (1965)

and on p. 478 the large intestine 'is not only larger in caliber than the small intestine, but it is also more firmly attached to the posterior abdominal wall by mesentry.'The parts of the book dealing with physiology are clear, informative and uniform in treatment.The authors give the impression of attempting to cover too wide a field.The quality of reproduction, printing and paper is very good.
Boxing and Medicine
Authors: Joel M. Press
Journal: JAMA (1996)

<i>Boxing and Medicine</i>is one of the few sports medicine books that looks at a sport from more than a purely medical standpoint. Dr Cantu and contributors have compiled a unique blend of up-to-date information on both the medical aspects of boxing and the psychosocial issues affecting the individual athlete and society's perception of the sport. The intent of<i>Boxing and Medicine</i>is to respond to the growing sentiment that the sport should be eliminated and to present a balanced description of boxing and its medical risks, athletes, and position in society. The book begins by comparing the dangers of boxing with those of other, more socially accepted sporting activities, such as college football, motorcycle racing, scuba diving, mountaineering, hang gliding, sky diving, and horseracing. Interestingly, the chance of fatality in boxing is 1.3 per 100 000 participants, which is a fraction of the risk in these other sports. The
Kaposi Sarcoma and Plasma Cell Dyscrasia
Authors: Ivan P. Law
Journal: JAMA (1974)

A patient with Kaposi sarcoma also had plasma cell leukemia. Review of the literature showed three additional patients with multiple myeloma, and several with paraproteinemia and bone marrow plasmacytosis. All patients shared the same fulminant clinical course. Generalized lymphadenopathy, hepatosplenomegaly, and anemia were common findings in patients with paraproteinemia and bone marrow plasmacytosis, but were uncommon in patients with multiple myeloma. (<i>JAMA</i>229:1329-1331, 1974)
A Reminder of "Auld Lang Syne."
Authors: Thos. Law
Journal: JAMA (1905)

New York, April 25, 1905. <h3>To the Editor:</h3> —Through the courtesy of Mr. James Douglas of New York I have a copy of the papers relating to the apprenticeship of his father when he became a student of medicine. Notwithstanding that this was made in the early part of the last century, the paper is so curiously quaint and interesting that I send a copy of it to you for publication inThe Journal. Few in the present day realize the great changes that have taken place in less than one hundred years. Thomas Darlington, Commissioner of Health. "THIS INDENTURE Made the third Day of October in the year of our Lord one thousand eight hundred and thirteen between The Reverend George Douglas of Penrith in the county of Cumberland and James Douglas of the same place the son of the same George Douglas of the one part and Thomas
Problems With Condom Catheters
Authors: Peter Press
Journal: JAMA (1990)

<h3>To the Editor.—</h3> I have always enjoyed reading the Question and Answer section of<i>JAMA</i>. Dr Cotsonas<sup>1</sup>wrote the funniest parody on problem solving I have read. The question on how to stick on a condom catheter was straightforward. The answer was a quarter-page dissertation on advice, consisting of developing a master plan, adapting and keeping diaries, anticipating incontinence (oxymoron?), maintaining emphasis of continuity of interaction, evolution of solutions, agreeing on goals (long and short), maintaining open channels (terrific!), and finally, information sharing between patients. In wiping away the tears of laughter, I had the fleeting thought of how sad it would be if the answer was for real. May I offer a practical answer: Wipe the base of the penis with Skin Care, an adhesive enhancer less irritating and better than benzoin tincture, allow to dry, then use Microfoam tape to hold the condom in place.
OXYGEN INHALATION IN THE TREATMENT OF SPONTANEOUS PNEUMOTHORAX
Authors: E PRESS
Journal: Annals of Internal Medicine (1947)

Case Reports1 July 1947OXYGEN INHALATION IN THE TREATMENT OF SPONTANEOUS PNEUMOTHORAXEDWARD PRESSEDWARD PRESSAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-1-135 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSo-called benign, idiopathic, spontaneous pneumothorax has been recognized more and more frequently during the past two or three decades. Inasmuch as this is chiefly an illness of apparently healthy, young males, it is not infrequent in the armed forces. In 1943, there were 873 hospital admissions with a primary diagnosis of spontaneous pneumothorax in the Army in the continental United States.1 The treatment in common usage consists of bed rest and mild sedation. The average length of hospitalization in the army cases quoted above was 40 days per person.In addition to the above conservative treatment, other methods have been...Bibliography1. "News and Comment": Bull. U. S. Med. Dept., 1944, lxxxii, 29. Google Scholar2. WARING JJ: Bull. Nat. Research Council, July, 1944, quoted in "News and Comment," Bull. U. S. Army Med. Dept., 1944, lxxxii, 29. Google Scholar3. WELKINDHERMAN AM: Rapid reëxpansion of lungs; pleural lavage with oxygen: further studies, Quart. Bull. Sea View Hosp., 1941, vi, 208-224. Google Scholar4. PHILIPSKNOEPP JRLF: Spontaneous pneumothorax, Dis. Chest, 1940, vi, 243-248. CrossrefGoogle Scholar5. MACKLINMACKLIN MTCC: Malignant interstitial emphysema of the lungs and mediastinum as an important occult complication in many respiratory diseases and other conditions: an interpretation of the clinical literature in the light of laboratory experiment, Medicine, 1944, xxiii, 281-359. CrossrefGoogle Scholar6. FINEBANKSSEARSHERMANSON JBMJBL: Treatment of gaseous distension of intestine by inhalation of 95 per cent oxygen. Description of apparatus for clinical administration of high oxygen mixtures, Ann. Surg., 1936, ciii, 375-387. CrossrefGoogle Scholar7. SCHWABFINEMIXTER RSJWJ: Reduction of postencephalographic symptoms by inhalation of 95 per cent oxygen, Arch. Neurol. and Psychiat., 1937, xxxvii, 1271-1282. CrossrefGoogle Scholar8. WARING JJ Denver, Colorado, Personal communication. Google Scholar9. LOVELACE WR, Col. M.C., Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: M.C. A.U.S. Englishtown, New Jersey*Received for publication October 2, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPneumothorax and pneumomediastinum in the first three days of lifeSpontaneous Pneumothorax in the Newborn 1 July 1947Volume 27, Issue 1Page: 135-137KeywordsArmed forcesHospitalizationsInhalationOxygenSedation Issue Published: 1 July 1947 PDF downloadLoading ...
Acute Myeloid Leukemia in the Elderly: Assessment of Multidrug Resistance (MDR1) and Cytogenetics Distinguishes Biologic Subgroups With Remarkably Distinct Responses to Standard Chemotherapy. A Southwest Oncology Group Study
Authors: Catherine P. Leith, Kenneth J. Kopecky, John Godwin, Thomas McConnell, Marilyn L. Slovak, I-Ming Chen, David R. Head, Frederick R. Appelbaum, Cheryl L. Willman
Journal: Blood (1997)
Studies of Experimental Transmission of Leukemogenic Virus Infection in Mice
Authors: L. W. Law
Journal: JNCI Journal of the National Cancer Institute (1965)

Attempts were made to detect transmission of Moloney leukemogenic virus (MLV) infection in mice of several susceptible strains. Neonatalcontact mice were caged either with potentially infectious young or adultinfectors of the established high-leukemic strains C3Hf*/Lw, C3Hf */Bi/ and RF*. Little or no evidence of contact infection was observed under what is considered optimal conditions for “horizontal” transmission of virus. Oral washings and urine, however, were infectious when introduced parenterally into susceptible low-leukemic mice. It is concluded that contact infections in natural environments must be minimal.
No One Wants Girls Except...
Authors: Shirley Press
Journal: JAMA (1983)

The other day I was shopping for a humorous greeting card to congratulate a friend on the birth of her daughter. I was struck by the fact that the card shop displayed six different cards for baby boys and only two for baby girls. This was a reminder of a long-nagging suspicion that American parents prefer boys over girls. A quick trip to the public library for some research seemed to confirm these thoughts. 1,2   So many times in my private practice of pediatrics, I have seen disappointment in the faces of fathers and mothers when girls were born. One time I found a mother crying over the birth of her second healthy daughter. She told me that she and her husband wanted a boy and that she wasn't sure she could love this baby. I told her, half seriously, that I would adopt and love the baby. The next
Crack and Fatal Child Abuse
Authors: Shirley Press
Journal: JAMA (1988)

<h3>To the Editor.—</h3> Crack, a preprocessed cocaine alkaloid, emerged in the Bahamas in 1983.<sup>1</sup>In late 1985, crack became available on the streets of New York City.<sup>2</sup>This potent, highly addictive smokable form of cocaine has been associated with physical complaints as well as psychiatric complaints that include depression, irritability, paranoia, and violent behavior.<sup>3</sup> The incidence of child abuse and neglect is known to be higher in families in which parents or caretakers are alcoholics or narcotic addicts. Reporting of child abuse and neglect has increased nationally 212% from 1976 to 1986 to more than 2 million cases a year. The number of fatalities also has risen.<sup>4</sup> At our hospital, since March 1988 we have seen three unrelated patients, ages 1 month, 2 years, and 3 years, as victims of fatal child abuse from battering. In two of the cases crack was specifically noted to have
Randomized clinical trials: design, practice and reporting
Authors: M. Law
Journal: Gut (2010)

Edited by David Machin, Peter M Fayers. . Published by Wiley-Blackwell, Chichester, 2010, 361, £39.99 (Softcover). ISBN-978-0-471-49812-4

A search of the Amazon website reveals 80 books on clinical trials, 20 of them paperbacks for generalists like this one. So why do so many people write them, and why do we need another? This book does not tell us; we can only speculate. Clearly though the field is a competitive one. We are told that the book is targeted towards clinicians who wish to be involved in clinical trials research. It contains far more detail than this readership would need: like many textbooks perhaps, the agenda is set more by the desire of the authors to impart information than the need of the readers to receive it.

Overall it must be said that this book is sound and comprehensive and will not lead clinicians astray. The problem is that the same could probably be said for most of the other 80 books. Clinicians will know half this material already …
Adult obesity and growth in childhood
Authors: C. Law
Journal: BMJ (2001)

Over half of all adults in the United States and the United Kingdom are overweight, and developing countries are increasingly facing the public health problems of overnutrition as well as undernutrition.1 In the past 20 years or so, the prevalence of obesity and overweight in both adults and children has increased dramatically.2 These time and geographical trends argue against a primarily genetic cause of obesity, and both behavioural and pharmaceutical interventions in obesity have limited effectiveness.3 Prevention through environmental, social, or behavioural interventions is a logical focus for tackling this epidemic.

The possibility of preventing adult obesity by taking action in infancy and childhood is attractive. Several studies have shown a weak relation between being heavy at birth and becoming overweight in later life. Others have found that faster growth in childhood predicts obesity in adulthood.4 In this week's issue (p 1331) Parsons et al replicate these findings in a large British birth cohort study followed to age …
AG-120, an Oral, Selective, First-in-Class, Potent Inhibitor of Mutant IDH1, Reduces Intracellular 2HG and Induces Cellular Differentiation in TF-1 R132H Cells and Primary Human IDH1 Mutant AML Patient Samples Treated Ex Vivo
Authors: Erica Hansen, Cyril Quivoron, Kim Straley, René M Lemieux, Janeta Popovici-Muller, Hossein Sadrzadeh, Amir T Fathi, Camelia Gliser, Muriel David, Véronique Saada, Jean-Baptiste Micol, Olivier Bernard, Marion Dorsch, Hua Yang, Michael Su, Sam Agresta, Stéphane de Botton, Virginie Penard-Lacronique, Katharine Yen
Journal: Blood (2014)
Closed Incomplete Rupture of Pectoralis Major
Authors: W. B. Law
Journal: BMJ (1954)

MEDICAL JOURNAL&x considered unnecessary.The wound was then closed in layers, positive intrathoracic pressure being induced by the anaesthetist before final closure of the thorax.Apart from transitory paralytic ileus and a pleural effusion which required aspiration, the patient made an excellent recovery and returned to work in the middle of July.DISCUSSION
Screening without evidence of efficacy
Authors: Malcolm Law
Journal: BMJ (2004)

Screening of unproved value should not be advocated 

Screening has intuitive appeal. Cancer, for example, causes a quarter of all deaths, and a doctor does not diagnose many incurable cancers without wanting some means of bringing forward the diagnosis. Before any screening for cancer is introduced, however, large randomised trials with mortality end points should be conducted to establish and quantify any benefit. But there is a view that there must be some gain from earlier diagnosis; awaiting trial results is a needless delay. The scientific rigour applied to other areas of medicine may not always be applied to screening.

Cancer of the prostate is an example. The serum concentration of prostate specific antigen can predict mortality from prostate cancer.1–4 There are no published randomised trials that the earlier detection improves prognosis, yet in the United States and Italy a third or more of healthy men aged over 50 have had prostate specific antigen measured in the past two years.4 5 In Britain, on the other hand, only 5% have,5 and the available evidence on prostate specific antigen testing in reducing mortality indicates that the British are right to reject it.

A problem with using prostate specific antigen (or any chemical produced by a cancer) as a marker for screening is that the serum concentration will increase …
Transgenic approaches to reintegration
Authors: W LAW
Journal: Cardiovascular Research (2006)

See article by Willems et al.  [1]  (pages 79–87) in this issue. 

The goal of physiology has always been to understand how organisms function. In a far-reaching field that encompasses aspects of biology, chemistry, and physics, the three mainstays of the physical sciences, terms such as homeostasis, or Claude Bernard's concept of the ‘milieu interior,’ have often been used to define the balance amongst many diverse processes that yield the net outcome determining health or disease, life or death. In our drive to understand these processes, we have taken a reductionist approach to increasingly smaller and more detailed avenues of inquiry. These avenues have led to fantastic discoveries and the development of entire disciplines, including genomics, transcriptomics, proteomics, and most recently (or, in the mind of some, a return to) metabolomics. Investigations in these realms have increased our understanding of the detailed components that comprise physiological processes, and undoubtedly will continue to … 

* Tel.: +1 215 596 8919; fax: +1 215 596 7443. Email address: w.law{at}usip.edu
Rhoda Rebecca Law
Authors: George Enderby
Journal: BMJ (2004)

A pioneer of hypotensive anaesthesiaHale Enderby is best known for his pioneering work in hypotensive anaesthesia.This is the technique of lowering blood pressure during surgery, making operations safer and more rapid, and enabling more complicated surgery while controlling blood loss from the patient.In 1948-9 the pharmacologists Paton and Zaimis first described a range of new drugs, the methonium compounds, some of which could lower blood pressure.Hale Enderby saw that this fall in blood pressure could be used to lessen bleeding during surgery-the snag was measuring the low blood pressures.Early methods of measurement relied on using a mercury column, but the Korotkov sounds become inaudible below 60 mm Hg systolic.The pulse also becomes impalpable at that pressure.However, this was the level of blood pressure needed to reduce bleeding significantly.Hale Enderby introduced into anaesthesia the oscillometer, an older and largely forgotten method of blood pressure measurement but one that proved capable of measuring accurately these low pressures.He was also responsible for introducing the "anti-trendelenburg" or head-up tilt of the operating table to assist in the lowering of blood pressure.George Edward Hale Enderby was born in Boston, Lincolnshire.At the start of the second world war he joined the emergency medical service after being turned down for active military service because of a duodenal ulcer.He worked initially at Guy's Hospital and then at Pembury Hospital, Kent, to which many of the Guy's facilities were moved after the hospital was bombed at the start of the war.It was there that he was asked to move into anaesthesia.He organised most of his training himself by reading and visiting notable anaesthetists of the day.
Immune Surveillance Revisited
Authors: Lloyd W. Law
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Immune Surveillance Revisited Get access Lloyd W. Law Lloyd W. Law Laboratory of Cell Biology National Cancer Institute, Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 54, Issue 1, January 1975, Pages 280–281, https://doi.org/10.1093/jnci/54.1.280b Published: 01 January 1975
Differential diagnosis of ulcerative lesions in fish.
Authors: M Law
Journal: Environmental Health Perspectives (2001)

Tissues such as skin and muscle have a limited repertoire of morphological response to injury. The two most important phenomena that determine the outcome of cell injury appear to be a) critical cell membrane damage, with associated fluid and ionic imbalances; and b) inability of mitochondria, the powerhouse of the cell, to restart ATP synthesis. In fish, skin ulcers can have many different etiologies, including infectious agents, toxins, physical causes, immunologic causes, and nutritional and metabolic perturbations. This article is concerned primarily with the possible pathways of disease involved in ulcerative lesions of fish. In particular, the high prevalence of ulcerative lesions in Atlantic menhaden found along the mid-Atlantic coast, especially in North Carolina estuarine waters, has received much recent attention. These ulcerative lesions are likely to be initiated by a series of factors that lead ultimately to a breach of the normal barrier function of the skin. Bioassays that attempt to define the role of individual etiologic agents such as fungi (oomycetes) or putative Pfiesteria toxin(s) should recognize this multiplicity of factors and should include appropriate quality control measures for water quality parameters (temperature, dissolved oxygen, nitrogenous wastes, etc.) as well as bacterial and other contaminants that may confound bioassay results and their interpretation. Consideration of these factors along with the whole animal in the context of its environment can only advance the science, perhaps provide clues to the causative pathways of skin ulcers in fish, and give us keener insight into the health of the aquatic environment.