tbuckley/cabot-search huggingface dataset:
Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia
Authors: Kiyomi Morita, Hagop M. Kantarjian, Feng Wang, Yuanqing Yan, Carlos Bueso-Ramos, Koji Sasaki, Ghayas C. Issa, Sa Wang, Jeffrey Jorgensen, Xingzhi Song, Jianhua Zhang, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Latasha Little, Curtis Gumbs, Naveen Pemmaraju, Naval Daver, Courtney D. DiNardo, Marina Konopleva, Michael Andreeff, Farhad Ravandi, Jorge E. Cortes, Tapan Kadia, Elias Jabbour, Guillermo Garcia-Manero, Keyur P. Patel, P. Andrew Futreal, Koichi Takahashi
Journal: Journal of Clinical Oncology (2018)

Purpose The aim of the current study was to determine whether the degree of mutation clearance at remission predicts the risk of relapse in patients with acute myeloid leukemia (AML). Patients and Methods One hundred thirty-one previously untreated patients with AML who received intensive induction chemotherapy and attained morphologic complete remission (CR) at day 30 were studied. Pretreatment and CR bone marrow were analyzed using targeted capture DNA sequencing. We analyzed the association between mutation clearance (MC) on the basis of variant allele frequency (VAF) at CR (MC2.5: if the VAF of residual mutations was &lt; 2.5%; MC1.0: if the VAF was &lt; 1%; and complete MC [CMC]: if no detectable residual mutations) and event-free survival, overall survival (OS), and cumulative incidence of relapse (CIR). Results MC1.0 and CMC were associated with significantly better OS (2-year OS: 75% v 61% in MC1.0 v non-MC1.0; P = .0465; 2-year OS: 77% v 60% in CMC v non-CMC; P = .0303) and lower CIR (2-year CIR: 26% v 46% in MC1.0 v non-MC 1.0; P = .0349; 2 year-CIR: 24% v 46% in CMC v non-CMC; P = .03), whereas there was no significant difference in any of the above outcomes by MC2.5. Multivariable analysis adjusting for age, cytogenetic risk, allogeneic stem-cell transplantation, and flow cytometry–based minimal residual disease revealed that patients with CMC had significantly better event-free survival (hazard ratio [HR], 0.43; P = .0083), OS (HR, 0.47; P = .04), and CIR (HR, 0.27; P &lt; .001) than did patients without CMC. These prognostic associations were stronger when preleukemic mutations, such as DNMT3A, TET2, and ASXL1, were removed from the analysis. Conclusion Clearance of somatic mutation at CR, particularly in nonpreleukemic genes, was associated with significantly better survival and less risk of relapse. Somatic mutations in nonpreleukemic genes may function as a molecular minimal residual disease marker in AML.
Ad Libitum Mediterranean and Low‐Fat Diets Both Significantly Reduce Hepatic Steatosis: A Randomized Controlled Trial
Authors: Catherine Properzi, Therese A. O'Sullivan, Jill L. Sherriff, Helena L. Ching, Garry P. Jeffrey, Rachel F. Buckley, Jonathan Tibballs, Gerry C. MacQuillan, George Garas, Leon A. Adams
Journal: Hepatology (2018)

Although diet-induced weight loss is first-line treatment for patients with nonalcoholic fatty liver disease (NAFLD), long-term maintenance is difficult. The optimal diet for improvement in either NAFLD or associated cardiometabolic risk factors, regardless of weight loss, is unknown. We examined the effect of two ad libitum isocaloric diets (Mediterranean [MD] or low fat [LF]) on hepatic steatosis (HS) and cardiometabolic risk factors. Subjects with NAFLD were randomized to a 12-week blinded dietary intervention (MD vs. LF). HS was determined by magnetic resonance spectroscopy (MRS). From a total of 56 subjects enrolled, 49 completed the intervention and 48 were included for analysis. During the intervention, subjects on the MD had significantly higher total and monounsaturated fat, but lower carbohydrate and sodium, intakes compared to LF subjects (P < 0.01). At week 12, HS had reduced significantly in both groups (P < 0.01), and there was no difference in liver fat reduction between groups (P = 0.32), with mean (SD) relative reductions of 25.0% (±25.3%) in LF and 32.4% (±25.5%) in MD. Liver enzymes also improved significantly in both groups. Weight loss was minimal and not different between groups (-1.6 [±2.1] kg in LF vs -2.1 [±2.5] kg in MD; P = 0.52). Within-group improvements in Framingham Risk Score (FRS), total cholesterol, serum triglyceride (TG), and glycated hemoglobin (HbA1c) were observed in the MD (all P < 0.05), but not with the LF diet. Adherence was higher for the MD compared to LF (88% vs. 64%; P = 0.048). Conclusion: Ad libitum low-fat and Mediterranean diets both improve HS to a similar degree.
Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease
Authors: Bradley S. Marino, Sarah Tabbutt, Graeme MacLaren, Mary Fran Hazinski, Ian Adatia, Dianne L. Atkins, Paul A. Checchia, Allan DeCaen, Ericka L. Fink, George M. Hoffman, John L. Jefferies, Monica Kleinman, Catherine D. Krawczeski, Daniel J. Licht, Duncan Macrae, Chitra Ravishankar, Ricardo A. Samson, Ravi R. Thiagarajan, Rune Toms, James Tweddell, Peter C. Laussen
Journal: Circulation (2018)

Cardiac arrest occurs at a higher rate in children with heart disease than in healthy children. Pediatric basic life support and advanced life support guidelines focus on delivering high-quality resuscitation in children with normal hearts. The complexity and variability in pediatric heart disease pose unique challenges during resuscitation. A writing group appointed by the American Heart Association reviewed the literature addressing resuscitation in children with heart disease. MEDLINE and Google Scholar databases were searched from 1966 to 2015, cross-referencing pediatric heart disease with pertinent resuscitation search terms. The American College of Cardiology/American Heart Association classification of recommendations and levels of evidence for practice guidelines were used. The recommendations in this statement concur with the critical components of the 2015 American Heart Association pediatric basic life support and pediatric advanced life support guidelines and are meant to serve as a resuscitation supplement. This statement is meant for caregivers of children with heart disease in the prehospital and in-hospital settings. Understanding the anatomy and physiology of the high-risk pediatric cardiac population will promote early recognition and treatment of decompensation to prevent cardiac arrest, increase survival from cardiac arrest by providing high-quality resuscitations, and improve outcomes with postresuscitation care.
TCTAP C-200 Chronic Left Main and Left Anterior Descending Dissection in a Young Woman: Optical Coherence Tomography Role to Indicate Optimal Treatment
Authors: Luca Testa, Riccardo Gorla, Mauro Luca Agnifili, Mario Bollati, Giovanni Bianchi, Francesco Bedogni
Journal: Journal of the American College of Cardiology (2018)
Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity
Authors: H. Takaya, K. Kaji, S. Saikawa, M. Furukawa, S. Sato, Y. Sawada, H. Kawaratani, M. Kitade, K. Moriya, T. Namisaki, T. Akahane, A. Mitoro, H. Yoshiji
Journal: Journal of Hepatology (2018)
Personalized T cell therapy against HBV-related hepatocellularcarcinoma
Authors: A. Tan, T. Krishnamoorthy, N. Yang, D. Low, Y.L. Tham, A. Khakpoor, E. Felinska, V. Oei, R. Giri, Z.Z. Ho, H.K. Tan, R. Kumar, W. Hwang, E. Guccione, W.C. Chow, A. Bertoletti
Journal: Journal of Hepatology (2018)
Is HCV elimination among HIV-infected people who inject drugs possible through HCV treatment targeting HIV/HCV coinfection? A modeling analysis for Andalusia, Spain
Authors: B. Skaathun, A. Borquez, A. Rivero-Juarez, F. Tellez, M. Castano, D. Merino, J. Santos, J.M. Sanchez, A. Rivero, N. Martin
Journal: Journal of Hepatology (2018)
Abstract P238: Remission/Cure of Autoimmune Diseases by a Lectin Limite Diet Supplemented With Probiotics, Prebiotics, and Polyphenols
Authors: Steven R Gundry
Journal: Circulation (2018)

All autoimmune diseases are highly associated with increased rates of coronary artery and vascular disease secondary to immune cell attack on epithelial cells. The causes of autoimmune disease (AID) seem to be multifactorial. However, the idea that derangement of the microbiome, breaches of the intestinal barrier (leaky gut) and introduction into the human diet of plant defense molecules such as lectins, which are capable of molecular mimicry, prompted our group to investigate the application of a lectin limited diet, coupled with probiotics and prebiotics (The Pant Paradox Protocol) to impact biomarker proven autoimmune disease activity in humans and their impact on endothelial biomarkers of inflammation. One hundred and two consecutive patients with immunoassay markers of autoimmune disease activity, i.e., RF, anti-CCP, ANA, Histone, etc, and signs and symptoms of RA, Lupus, Sjogrens, Crohns, Colitis, Scleroderma, Mixed Connective Tissue Disease, and biomarkers of endothelial inflammation, were enrolled into a program of elimination of major dietary lectins, consisting of all grains and pseudo grains, beans and legumes, peanuts, cashews, nightshades, squashes, and Casein A1 milk products (The Plant Paradox Program), supplemented with probiotics and prebiotics including resistant starches and polyphenol supplements. All pts initially low Vit D levels and low Omega 3 index and adiponectin levels above 16mg/dl. Biomarkers of inflammation, hs-CRP, TNF-alpha, IL-6, fibrinogen, myeloperoxidase and autoimmune markers were measured every 3 months. 95/102 patients achieved complete resolution of autoimmune markers and inflammatory markers within 9 months. The other 7/102 patients all had reduced markers, but incomplete resolution. 80/102 patients were weaned from all immunosuppressive and/or biologic medications without rebound. We conclude that a lectin limited diet, supplemented with pro and prebiotics, and polyphenols are capable of curing or putting into remission most autoimmune diseases.
Baseline neutrophil-to-lymphocyte ratio in patients with advanced melanoma treated with immune checkpoint inhibitors
Authors: L. Machet, J. Zaragoza, A. Finon, M. Garnier, H. Maillard, A. Caille
Journal: British Journal of Dermatology (2018)

Linked Article:Fujisawa etal. Br J Dermatol 2018; 179:213–215.
Sudden Cardiac Deaths—WHO Says They Are Always Arrhythmic?
Authors: Zian H. Tseng
Journal: JAMA Cardiology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Annals Story Slam - On Being Vulnerable
Authors: J. Kevin Dorsey
Journal: Annals of Internal Medicine (2018)

Web Exclusives17 April 2018Annals Story Slam - On Being VulnerableFREEJ. Kevin Dorsey, MD, PhDJ. Kevin Dorsey, MD, PhDSIU Medicine, Springfield, Illinois (J.K.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W18-0010 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - On Being Vulnerable "On Being Vulnerable," by Dr. J. Kevin Dorsey (Duration 6:22)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: SIU Medicine, Springfield, Illinois (J.K.D.)Corresponding Author: J. Kevin Dorsey, MD, PhD; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 April 2018Volume 168, Issue 8Page: SS1 ePublished: 17 April 2018 Issue Published: 17 April 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.Loading ...
Expression of IL-33 and TSLP and Their Receptors in Asthmatic Airways after Inhaled Allergen Challenge
Authors: Dhuha Al-Sajee, Roma Sehmi, Thomas J. Hawke, Amani El-Gammal, Karen J. Howie, Richard M. Watson, Marco Londei, Gail M. Gauvreau, Paul M. O’Byrne
Journal: American Journal of Respiratory and Critical Care Medicine (2018)
Evidence to Support Monitoring of Vedolizumab Trough Concentrations in Patients With Inflammatory Bowel Diseases
Authors: Erwin Dreesen, Bram Verstockt, Sumin Bian, Magali de Bruyn, Griet Compernolle, Sophie Tops, Maja Noman, Gert Van Assche, Marc Ferrante, Ann Gils, Séverine Vermeire
Journal: Clinical Gastroenterology and Hepatology (2018)
Post transcriptional regulation of Hepatitis B virus in a prospective cohort of chronically infected patients
Authors: A. Schnuriger, M. Yassmina, S. Gourari, B. Lekbaby, T. Attout, H. Wang, J. Augustin, D. Kremsdorf, N. Debzi, P. Soussan
Journal: Journal of Hepatology (2018)
P531Mitochondria of parental cells control the capacity of monocyte-derived microvesicles to activate endothelial cells
Authors: F Puhm, T A Afonyushkin, G O Obermayer, U R Resch, I M Melki, G W Wagner, N M Mackman, B J Jilma, E B Boilard, CJB Binder
Journal: Cardiovascular Research (2018)
Climate Velocity Can Inform Conservation in a Warming World
Authors: Isaac Brito-Morales, Jorge García Molinos, David S. Schoeman, Michael T. Burrows, Elvira S. Poloczanska, Christopher J. Brown, Simon Ferrier, Tom D. Harwood, Carissa J. Klein, Eve McDonald-Madden, Pippa J. Moore, John M. Pandolfi, James E.M. Watson, Amelia S. Wenger, Anthony J. Richardson
Journal: Trends in Ecology & Evolution (2018)
After Bawa-Garba: what the future holds for a medical profession feeling let down by its regulator
Authors: Zosia Kmietowicz
Journal: BMJ (2018)

Doctors work in fear of a complaint being made against them, and the system that regulates them is too arbitrary, medical professionals told a meeting on the lessons to be learnt from the Hadiza Bawa-Garba case.

The General Medical Council (GMC) is considering how to tackle the “considerable variation” in how medical manslaughter applies to doctors around the UK as a matter of urgency, said the regulator’s chief executive, Charlie Massey, so that doctors are more fairly treated.

Bawa-Garba, a trainee paediatrician, was convicted of gross negligence manslaughter in 2015 after the death of 6 year old Jack Adcock in Leicester Royal Infirmary,1 and she was recommended for a 12 month suspension by a medical practitioners tribunal. But the GMC appealed to High Court, and she was struck off in January.2

The case has left medical professionals in a state of anxiety, unsure of how to keep the patient safety agenda moving forwards while protecting themselves from possible legal action.3

“When you talk to doctors the over-riding issue is fear, because patients are encouraged to complain,” said Clare Gerada, a GP and former chair of the Royal College of General Practitioners, at the meeting organised by The BMJ and the King’s Fund on 8 May. “Even myself—towards …
Down expression of activin A receptor type 2A in relation to metastatic potential and prognosis of patients with colon cancer.
Authors: Changhua Zhuo, Dan Hu, Xiandong Lin, Ying Chen, Xiongwei Zheng, Chunkang Yang
Journal: Journal of Clinical Oncology (2018)

712 Background: The ACVR2A (activin A receptor type 2A) is a membrane receptor in TGF-β signal pathway, which is involved in the regulation of cell proliferation, migration and apoptosis. The expression profiles and biological functions of ACVR2A in colon cancer is largely unknown so far. Methods: ACVR2A expression was investigated using GSE39582 database and two validation cohorts. The in vitro study of the cell proliferation and migration of human colon cell lines was also performed. Results: In GSE39582 database (n = 497), lower mRNA expression of ACVR2A was identified as an inferior prognostic factor by linear regression analysis. In one validation cohort of 15 stage IV patients, the mRNA expression of ACVR2A was significantly reduced in metastatic lesions and primary tumors compared with adjacent normal controls (P = 0.001). In another validation cohort of tissue microarray (TMA) cohort consisting 193 cases, reduced ACVR2A expression was correlated with advanced N stage (P = 0.001) and positive lymphovascular invasion (P = 0.005). Strong correlations between lower ACVR2A mRNA or protein expression and worse survival were also observed in GSE39582 database and TMA validation cohort (all P&lt; 0.05). Moreover, our in vitro studies showed a remarkable increase of cell migration in cell ACVR2A knockdown cells. Conclusions: Taken together, our findings indicate that loss of ACVR2A has an important role in cancer progression and distant metastasis, and may serve as a prognostic marker in patients with colon cancer. Keywords: Activin a receptor type 2A (ACVR2A), Colon Cancer, tissue microarray, Metastasis, Cell proliferation, Cell migration
Usefulness of liver stiffness measurement by transient elastography for predicting complications in patients with alcoholic liver disease
Authors: A. Gomez, B. Redondo, M. Fraile, A. Castano-Garcia, M. Torner, M.L.G. Dieguez, V. Cadahía-Rodrigo, M. Varela, P. Alonso, C. Álvarez-Navascués, M. Rodríguez
Journal: Journal of Hepatology (2018)
Abstract 10634: Multiple Atrial Communications Presenting as Platypnea-Orthodeoxia Syndrome
Authors: Nishaki Mehta Oza, Fengting Yan, Stephen Johnson, John Cheatham, Curt Daniels
Journal: Circulation (2013)

We report a case of platypnea-orthodeoxia syndrome resulting from multiple inter-atrial communications with right-to-left shunting in a 73 year old woman. Our patient presented with progressive shortness of breath over the last eighteen months. She was on 10 liters of high flow oxygen at time of presentation to our hospital and was bed bound owing to severe dyspnea. Her history of chronic pulmonary emboli despite therapeutic coumadin levels and ulcerative colitis initially led to an exhaustive hepato-pulmonary work-up. On clinical exam, she was noted to have normal oxygen saturation with lying down, but with sitting up or walking she developed significant hypoxia and respiratory distress. With no evidence of lung parenchymal or vascular diseases, right heart catheterization was performed and revealed normal right sided pressures. Intracardiac echocardiography confirmed a typical appearing patent foramen ovale (PFO) with atrial septal aneurysm and bidirectional shunting, and a small inferior secundum atrial septal defect (ASD) Although the ASD was congenital, aortic dilation with ageing could have altered the location of the atrial septum which facilitated laminar blood flow from the inferior vena cava to the left atrium. We proceeded to close both defects with an Amplatzer Cribiform Occluder. Her symptoms dramatically improved 48 hours following closure and she was ambulating on room air at time of discharge. One month follow-up was notable for no recurrence of symptoms. PFOs and small ASDs are generally innocuous but could cause right to left shunting even in the absence of elevated right sided pressures. Excluding other causes of platypnea-orthodeoxia, and closing the atrial communications can lead to resolution of symptoms.
Utility of FDG-PET/CT in lymphoma patients undergoing immunotherapy with autologous CTL019 T-cells.
Authors: Nirav Niranjan Shah, Drew A. Torigian, Michael Farwell, Wei-Ting Hwang, Noelle V. Frey, Sunita Nasta, Daniel Jeffrey Landsburg, Anthony R. Mato, Carl H. June, Stephen J. Schuster, David L. Porter, Jakub Svoboda
Journal: Journal of Clinical Oncology (2015)

3022 Background: Molecular imaging with FDG-PET/CT (PET/CT) is an established modality for response assessment in lymphoma patients (pts) undergoing treatment (Tx). However, pts treated with novel immunotherapies may have false positive PET/CT findings due to tumor site and systemic inflammation. In particular, Tx with CTL019cells(autologous chimeric antigen receptor modified T-cells redirected at CD19) can be complicated by ‘cytokine release syndrome’ (CRS) due to a severe systemic inflammatory reaction. Infiltration of tumors by activated CTL019 cells may impact radiographic and functional imaging findings. The role of PET/CT in pts treated with CTL019has not previously been described. Methods: We performed a pilot, single arm, prospective study to explore the utility of early PET/CT in pts with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) undergoing Tx with CTL019 T-cells. Pts had PET/CT prior to CTL019infusion and then early PET/CT at 1 month (m) post-Tx. The primary outcome was the amount/change in metabolically active tumor volume (MTV) and FDG uptake. Secondary outcomes included the association of early PET/CT with formal response assessment by 3 m CT scan and the effect of CRS on PET/CT results. Results: We enrolled 6 pts (DLBCL 4; FL 2). 5 of 6 had baseline PET/CT with active disease. 4 of 6 pts developed CRS but all resolved symptoms prior to the 1 m scan. On the 1 m PET/CT, 3 had response (CR or PR) and 3 had disease progression (PD). There was 100% correlation of early PET/CT result with 3 month CT response assessment (Table). Development of CRS did not confound PET/CT findings. Conclusions: In DLBCL and FL pts on Tx with CTL019, early PET/CT may predict response to this novel immunotherapy. The development of CRS did not influence image assessment at 1 m. We plan to include early PET/CT in future CTL019 lymphoma studies to better define its role in this setting. Subject Disease CRS N=No Y=Yes Pre-Tx Total MTV (cc) Post-Tx Total MTV (cc) Absolute change in MTV(cc) Post-Tx PET/CT Deauville Score/Response 3 m CT response 13 FL N 54.7 0 -54.7 1/CR CR 16 DLBCL Y 0 32.7 + 32.7 5/PD PD 12 DLBCL Y 91.2 22.9 -68.3 4/PR PR 22 DLBCL Y 255.9 1625.3 + 1369.4 5/PD PD 19 FL Y 451.6 0 -451.6 2/CR CR 25 DLBCL N 121.3 369.8 + 248.5 5/PD PD
Microvascular complications in diabetes patients with heart failure and reduced ejection fraction—insights from the Beta‐blocker Evaluation of Survival Trial
Authors: Søren L. Kristensen, Rasmus Rørth, Pardeep S. Jhund, Li Shen, Matthew M. Y. Lee, Mark C. Petrie, Lars Køber, John J.V. McMurray
Journal: European Journal of Heart Failure (2018)
P360TWEAK or Fn14 insufficiency inhibits neointimal hyperplasia through reduction of Cyclin/CDKs expression and impaired vascular smooth muscle cells proliferation
Authors: N Mendez-Barbero, J Madrigal-Matute, P Minguez, C Gutierrez-Munoz, J Egido, J L Martin-Ventura, V Esteban, L Blanco-Colio
Journal: Cardiovascular Research (2018)
Neutral Theory, Transposable Elements, and Eukaryotic Genome Evolution
Authors: Irina R Arkhipova
Journal: Molecular Biology and Evolution (2018)

Among the multitude of papers published yearly in scientific journals, precious few publications may be worth looking back in half a century to appreciate the significance of the discoveries that would later become common knowledge and get a chance to shape a field or several adjacent fields. Here, Kimura's fundamental concept of neutral mutation-random drift, which was published 50 years ago, is re-examined in light of its pervasive influence on comparative genomics and, more specifically, on the contribution of transposable elements to eukaryotic genome evolution.