tbuckley/cabot-search huggingface dataset:
CHEMISTRY IN AMERICA, 1876-1926
Journal: JAMA (1926)

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Medical Education Theme Issue 2015
Authors: Robert M. Golub
Journal: JAMA (2015)

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PSYCHOLOGY OF EVERYDAY LIFE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac Assessment Before Stem Cell Transplantation for Systemic Sclerosis—Reply
Authors: Jacob M. van Laar, Dominique Farge, Alan Tyndall
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression
Authors: Vincent Bernard, Alexander Semaan, Jonathan Huang, F. Anthony San Lucas, Feven C. Mulu, Bret M. Stephens, Paola A. Guerrero, Yanqing Huang, Jun Zhao, Nabiollah Kamyabi, Subrata Sen, Paul A. Scheet, Cullen M. Taniguchi, Michael P. Kim, Ching-Wei Tzeng, Matthew H. Katz, Aatur D. Singhi, Anirban Maitra, Hector A. Alvarez
Journal: Clinical Cancer Research (2018)

Early detection of pancreatic ductal adenocarcinoma (PDAC) remains elusive. Precursor lesions of PDAC, specifically intraductal papillary mucinous neoplasms (IPMNs), represent a bona fide pathway to invasive neoplasia, although the molecular correlates of progression remain to be fully elucidated. Single-cell transcriptomics provides a unique avenue for dissecting both the epithelial and microenvironmental heterogeneities that accompany multistep progression from noninvasive IPMNs to PDAC.Single-cell RNA sequencing was performed through droplet-based sequencing on 5,403 cells from 2 low-grade IPMNs (LGD-IPMNs), 2 high-grade IPMNs (HGD-IPMN), and 2 PDACs (all surgically resected).Analysis of single-cell transcriptomes revealed heterogeneous alterations within the epithelium and the tumor microenvironment during the progression of noninvasive dysplasia to invasive cancer. Although HGD-IPMNs expressed many core signaling pathways described in PDAC, LGD-IPMNs harbored subsets of single cells with a transcriptomic profile that overlapped with invasive cancer. Notably, a proinflammatory immune component was readily seen in low-grade IPMNs, composed of cytotoxic T cells, activated T-helper cells, and dendritic cells, which was progressively depleted during neoplastic progression, accompanied by infiltration of myeloid-derived suppressor cells. Finally, stromal myofibroblast populations were heterogeneous and acquired a previously described tumor-promoting and immune-evading phenotype during invasive carcinogenesis.This study demonstrates the ability to perform high-resolution profiling of the transcriptomic changes that occur during multistep progression of cystic PDAC precursors to cancer. Notably, single-cell analysis provides an unparalleled insight into both the epithelial and microenvironmental heterogeneities that accompany early cancer pathogenesis and might be a useful substrate to identify targets for cancer interception.See related commentary by Hernandez-Barco et al., p. 2027.
Effectiveness of seasonal 2012/13 vaccine in preventing laboratory-confirmed influenza infection in primary care in the United Kingdom: mid-season analysis 2012/13
Authors: J McMenamin, N Andrews, C Robertson, D M Fleming, H Durnall, B von Wissmann, J Ellis, A Lackenby, S Cottrell, B Smyth, M Zambon, C Moore, J  M Watson, R  G Pebody
Journal: Eurosurveillance (2013)

The early experience of the United Kingdom (UK) is that influenza B has dominated the influenza 2012/13 season. Overall trivalent influenza vaccine (TIV) adjusted vaccine effectiveness (VE) against all laboratory-confirmed influenza in primary care was 51% (95% confidence interval (CI): 27% to 68%); TIV adjusted VE against influenza A alone or influenza B alone was 49% (95% CI: -2% to 75%) and 52% (95% CI: 23% to 70%) respectively. Vaccination remains the best protection against influenza.
Первые итоги применения сдвиговолновой транзиторной эластометрии в определении состояния паренхимы поджелудочной железы (обзор литературы и собственные исследования)
Authors: Yu.M. Stepanov, N.H. Hravyrovska
Journal: GASTROENTEROLOGY (2020)

Эластометрия является быстро развивающимся методом диагностики и позволяет выявлять и дифференцировать очаговые образования различного происхождения, а также стадировать фиброзную транс-формацию печени, о чем свидетельствует множество исследовательских работ. Метод прочно вошел в практику гастроэнтерологии. Появление аппаратов нового поколения с функцией ARFI (VTQ) и SWEI позволило ученым начать транзиторное исследование жесткости паренхимы поджелудочной железы. Однако работ этих пока немного, существует необходимость стандартизации техники выполнения исследования и его результатов при различных заболеваниях. Аппарат UltimaPAExpert® («Радмир», Украина) с функцией SWEI позволяет при применении определенных технических приемов провести транзиторную эластометрию (эластографию) поджелудочной железы с целью определения жесткости ее паренхимы в норме и при диффузной патологии. Показатели жесткости, получаемые на аппарате UltimaPAExpert® («Радмир», Украина), представлены в кПа и одновременно в м/с, что делает эти данные сопоставимыми с показателями, полученными другими исследователями на аппаратах, имеющих только одну измерительную функцию. У практически здоровых лиц получен показатель жесткости паренхимы поджелудочной железы (4,86 ± 0,05) кПа, (1,33 ± 0,05) м/с. При хроническом панкреатите этот показатель равен (6,48 ± 0,8) кПа, (1,52 ± 0,17) м/с. Полученные данные позволят определять тактику лечения, а также его эффективность, опираясь на показатели жесткости.
Activity of cabozantinib (XL184) in metastatic NSCLC: Results from a phase II randomized discontinuation trial (RDT).
Authors: Beth A. Hellerstedt, Gerald Edelman, Nicholas J. Vogelzang, Harriet M. Kluger, Christopher A. Yasenchak, Xiaodong Shen, David A. Ramies, Michael S. Gordon, Primo Lara
Journal: Journal of Clinical Oncology (2012)

7514 Background: Dysregulation of MET and VEGFR2 signaling has been observed in NSCLC and MET upregulation has been implicated in resistance to EGFR inhibitors. Cabozantinib (cabo) is an oral, potent inhibitor of MET and VEGFR2. A RDT evaluated activity and safety in 9 tumor types. Here we report on the metastatic NSCLC cohort which included patients who received prior EGFR and VEGF pathway targeted therapy. Methods: All eligible patients (pts) were required to have measurable disease at baseline. Pts received cabo at 100 mg qd over a 12 wk Lead-in stage. Tumor response (mRECIST) was assessed q6 wks. Treatment ≥ wk 12 was based on response: pts with PR continued open-label cabo, pts with SD were randomized to cabo vs placebo, and pts with PD discontinued. Results: Enrollment to this cohort is complete (n = 60); all pts are unblinded. Baseline characteristics: median age 67 years; adenocarcinoma 72% and squamous cell 28%; 6 pts with known EGFR mutation (of 28 tested), all having received prior erlotinib; bone metastases 20%; median prior lines of therapy 3 (range 0 - 6); prior exposure to anti-EGFR therapy 50%, prior exposure to anti-VEGF pathway therapy 32%. Median follow-up was 2 months (range 0.4 - 22.3 months). At Wk 12, ORR per RECIST was 10% and overall disease control rate (PR+SD) was 40%. Objective tumor regression was observed in 30/47 pts (64%) with post-baseline tumor assessments, some of whom had known driver mutations in KRAS (3 pts) or EGFR (4 pts). 24 pts (40%) completed Lead-in stage with 15 randomized to continue cabo (N = 8) or to placebo (N = 7). No differences with respect to PFS were observed between treatment arms in the randomized phase of the study. Median PFS from study day 1 for all pts was 4.2 months. Most common Grade 3/4 AEs were fatigue (13%), Palmar-plantar erythrodyesthesia (8%), diarrhea (7%) and asthenia (7%); one related Grade 5 AE of hemorrhage was reported during Lead-in stage. Conclusions: Cabo treatment demonstrates activity in heavily pretreated metastatic NSCLC pts with 4.2 months median PFS, 10% RECIST response, and 64% rate of objective tumor regression. The safety profile of cabo was comparable to that seen with other VEGFR TKIs. Future studies are warranted in NSCLC.
CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice
Authors: Sebastian Steven, Mobin Dib, Michael Hausding, Fatemeh Kashani, Matthias Oelze, Swenja Kröller-Schön, Alina Hanf, Steffen Daub, Siyer Roohani, Yves Gramlich, Esther Lutgens, Eberhard Schulz, Christian Becker, Karl J Lackner, Hartmut Kleinert, Christoph Knosalla, Beate Niesler, Philipp S Wild, Thomas Münzel, Andreas Daiber
Journal: Cardiovascular Research (2017)

Abstract Aims CD40 ligand (CD40L) signaling controls vascular oxidative stress and related dysfunction in angiotensin-II-induced arterial hypertension by regulating vascular immune cell recruitment and platelet activation. Here we investigated the role of CD40L in experimental hyperlipidemia. Methods and results Male wild type and CD40L−/− mice (C57BL/6 background) were subjected to high fat diet for sixteen weeks. Weight, cholesterol, HDL, and LDL levels, endothelial function (isometric tension recording), oxidative stress (NADPH oxidase expression, dihydroethidium fluorescence) and inflammatory parameters (inducible nitric oxide synthase, interleukin-6 expression) were assessed. CD40L expression, weight, leptin and lipids were increased, and endothelial dysfunction, oxidative stress and inflammation were more pronounced in wild type mice on a high fat diet, all of which was almost normalized by CD40L deficiency. Similar results were obtained in diabetic db/db mice with CD40/TRAF6 inhibitor (6877002) therapy. In a small human study higher serum sCD40L levels and an inflammatory phenotype were detected in the blood and Aorta ascendens of obese patients (body mass index &gt; 35) that underwent by-pass surgery. Conclusion CD40L controls obesity-associated vascular inflammation, oxidative stress and endothelial dysfunction in mice and potentially humans. Thus, CD40L represents a therapeutic target in lipid metabolic disorders which is a leading cause in cardiovascular disease.
Community-Acquired Pneumonia and Use of Gastric Acid–Suppressive Drugs—Reply
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neurofeedback for Attention-Deficit/Hyperactivity Disorder
Authors: Samuel J. Westwood, Pascal-M. Aggensteiner, Anna Kaiser, Peter Nagy, Federica Donno, Dóra Merkl, Carla Balia, Allison Goujon, Elisa Bousquet, Agata Maria Capodiferro, Laura Derks, Diane Purper-Ouakil, Sara Carucci, Martin Holtmann, Daniel Brandeis, Samuele Cortese, Edmund J. S. Sonuga-Barke, Dieter Baeyens, Tobias Banaschewski, Sven Bölte, Jan Buitelaar, David Coghill, Manfred Doepfner, Maite Ferrin, Cedric Galera, Barbara Van Den Hoofdakker, Chris Hollis, Jonna Kuntsi, Saskia Van der Oord, Jose Antoni Ramos-Quiroga, Marcel Romanos, Argyris Stringaris, Cesar A. Soutullo, Emily Simonoff, Paramala Santosh, Anita Thapar, Ian CK Wong
Journal: JAMA Psychiatry (2024)

Neurofeedback has been proposed for the treatment of attention-deficit/hyperactivity disorder (ADHD) but the efficacy of this intervention remains unclear.
Painful Purple Toes
Authors: John J. Ross, Brendan M. Everett, Jennifer A. Johnson, Amy Miller
Journal: New England Journal of Medicine (2009)

A 57-year-old man presented to the emergency department with painful purple toes. He had first noted pain and discoloration in his left great toe 2 weeks earlier. One week before presentation, the pain and discoloration had progressed to involve the left second and third toes. During the preceding 3 weeks, the patient also had intermittent blurry vision, fleeting episodes of . . .
Medical Education Theme Issue 2013
Authors: Robert M. Golub
Journal: JAMA (2013)

Education costs money, but then so does ignorance.-Sir Claus Moser
Medical education is expensive. In contrast to other items of great cost, arguments against its necessity and importance are unlikely. Nevertheless, the value of current educational approaches can be questioned, whether on a large scale such as the length of medical training1 or on a more intimate scale such as length of attending physician inpatient rotations.2
Ignorance about how best to deliver medical education may not only cost dollars in lost efficiency in training, but may produce physicians who are not able to provide optimal medical care for their patients. The best hope for reducing such ignorance is high-quality research in medical education. To be done well, such research also costs money; the strongest research in medical education has had substantial funding.3- 4 But the large gaps in knowledge about medical education (related in part to limited research training, resources, and funding) are certainly costing money too.
ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: Executive Summary
Authors: Andrew E. Epstein, John P. DiMarco, Kenneth A. Ellenbogen, N.A. Mark Estes, Roger A. Freedman, Leonard S. Gettes, A. Marc Gillinov, Gabriel Gregoratos, Stephen C. Hammill, David L. Hayes, Mark A. Hlatky, L. Kristin Newby, Richard L. Page, Mark H. Schoenfeld, Michael J. Silka, Lynne Warner Stevenson, Michael O. Sweeney
Journal: Journal of the American College of Cardiology (2008)
Monitoring of minimal residual disease in acute myeloidleukemia with frequent and rare patient-specific NPM1 mutations
Authors: Dana Dvořáková, Zdeněk Ráčil, Ivana Ježíšková, Ivo Palásek, Markéta Protivánková, Martina Lengerová, Filip Rázga, Jiří Mayer
Journal: American Journal of Hematology (2010)

Nucleophosmin (NPM1) mutations in exon 12 are the most common
genetic alternation in cytogenetically normal AML (CN-AML). In
this study, we have evaluated a novel, DNAbased real-time
quantitative polymerase chain reaction (RQ-PCR) for the
detection of three of the most commonly occurring mutations
(A,B,D) and for six rare patient-specific mutation types, which
represent 28% of all of the NPM1 mutations in our group of 25
CN-AML patients. Furthermore, the prognostic relevance of NPM1-
based monitoring of minimal residual disease (MRD) in
peripheral blood (PB), bone marrow (BM), and in specific cell
subsets (CD341, CD342, CD34dim) of BM were evaluated. In 80% of
the evaluable patients, a molecular relapse preceded a
hematological relapse. Moreover, in this subset of patients,
the molecular relapse occurred at a median of 97 days before
the hematological relapse. Our analysis showed a strong
correlation between BM and PB as well as a high copy number of
mutated NPM1 in CD341 BM cells. In conclusion, we have
demonstrated applicability of our presented RQPCR method for a
large percentage of mutated NPM1 patients with CN-AML as well
as the usefulness for long-term follow-up monitoring of MRD and
the prediction of hematological relapse.
The Health School on Wheels.
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit
Authors: Marija S. Nadjsombati, John W. McGinty, Miranda R. Lyons-Cohen, James B. Jaffe, Lucian DiPeso, Christoph Schneider, Corey N. Miller, Joshua L. Pollack, G.A. Nagana Gowda, Mary F. Fontana, David J. Erle, Mark S. Anderson, Richard M. Locksley, Daniel Raftery, Jakob von Moltke
Journal: Immunity (2018)
Safety in Physical Education in Secondary Schools
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal