tbuckley/cabot-search huggingface dataset:
Response to: ‘Spontaneous hypertensive rat exhibits bone and meniscus phenotypes of osteoarthritis: is it an appropriate control for MetS-associated OA?’ by Chan and Wen
Authors: Chaohua Deng, Arnaud Bianchi, Nathalie Presle, David Moulin, Meriem Koufany, Cécile Guillaume, Hervé Kempf, Anne Pizard
Journal: Annals of the Rheumatic Diseases (2017)

à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
A phase 1b study of RXDX-105, a VEGFR-sparing potent RET inhibitor, in RETi-naïve patients with RET fusion-positive NSCLC
Authors: A.E. Drilon, S. Liu, R. Doebele, C. Rodriguez, M. Fakih, K.L. Reckamp, L. Bazhenova, B.C. Cho, E. Kowack, J. Oliver, P. Multani, M-J. Ahn
Journal: Annals of Oncology (2017)
Baseline corticosteroids (CS) could be associated with absence of benefit to immune checkpoint inhibitors (ICI) in advanced non-small cell lung cancer (NSCLC) patients
Authors: G. Martínez Bernal, L. Mezquita, E. Auclin, R. Ferrara, D. Planchard, J. Remon Masip, J. Lahmar, M-E. Boucher, C. Caramella, J. Adam, A. Gazzah, J-C. Soria, B. Besse
Journal: Annals of Oncology (2017)
GW28-e0328 Qishen Granule attenuates inflammation-induced myocardial apoptosis through inhibiting cyclooxygenase2 (COX2) pathway
Authors: Linghui Lu, Yong Wang, Jing Wang, Qiyan Wang, Yi Zhang, Qian Zhang, Yan Wu, Chun Li, Wei Wang
Journal: Journal of the American College of Cardiology (2017)
GW28-e1175 Recanalization of stumpless chronic total occlusion with guidance by intravascular ultrasound in the side branch
Authors: Bin Wang, Han Yaling, Jing Quanmin, Xu Kai, Wang Xiaozeng, Ma Yingyan, Liang Zhenyang, Wang Geng, Liu Haiwei, Guan Shaoyi, Wang Shuang
Journal: Journal of the American College of Cardiology (2017)
Augmentation explosive de Salmonella Java dans la volaille aux Pays-Bas
Authors: W van Pelt, H van der Zee, W J B Wannet, A. W van de Giessen, D. J Mevius, N M Bolder, Y T H P van Duynhoven
Journal: Eurosurveillance (2003)

Aux Pays-Bas, l'infection a Salmonella Paratyphi B variant Java dans la volaille a augmente de moins de 2% de tous les isolats avant 1996, a environ 60% en 2002. En depit d'une exposition importante a la viande contaminee, les cas humains presentant une infection a Java sont rares (0,3% de tous les isolats), mais 50% des isolats humains montrent des profils en PFGE identiques au clone de volaille. Par ailleurs, la resistance de S. Java a la flumequine a augmente de 3% entre 1996-2000 a 19% en 2001 et 39% en 2002, alors que celle des autres serotypes s'est maintenue a environ 7%. S. Java devient egalement moins sensible a la ciprofloxacine.
PTH-071 The changing face of surgery for ulcerative colitis: analysis of 10 years of colectomy data
Authors: R Ratnakumaran, N Scott, AC Ford, PJ Hamlin
Journal: Gut (2017)

Introduction  One in four patients with ulcerative colitis (UC) may require surgery, but this figure is probably declining following NICE approval of biologics for acute severe (2008) and moderate (2015) UC. The IBD service standards (2009) advocate laparoscopic surgery where possible and advise auditing surgical outcomes. A retrospective audit of colectomy for UC in Leeds over the decade 2005–2015 was performed.  Method  Patients undergoing colectomy were identified from histology databases. Data on timing (elective, urgent (during admission with acute severe UC), or emergency (within 48 hours of admission for acute severe UC)), indication, and nature of the index procedure, grade of operator, surgical approach used, prior biologics, and complication rates were collected. Results for 2005–2009 were compared with 2010–2015 using a Chi 2  test.  Results  178 colectomies were performed between 2005 and 2015. 99 (55.6%) were elective (76 (76.8%) for failed medical therapy, 22 (22.2%) for dysplasia). 61 (34.3%) were urgent and 18 (10.1%) were emergency cases. Overall, 81 (47%) colectomies were performed laparoscopically (64 (68%) of elective cases vs. 17 (22%) of urgent/emergency cases (p  Conclusion  Fewer elective colectomies are being performed for UC, possibly attributed to increased biologic use. A greater proportion are done laparoscopically, with shorter lengths of stay. However, a significant greater proportion of patients are requiring urgent/emergency surgery, where mortality is higher.  Disclosure of Interest  None Declared
A Terrible Beauty
Authors: Carol Snyder Halberstadt
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neutrophil-to-lymphocyte ratio in metastatic breast cancer: Association with clinico-pathological features and outcome
Authors: M. Bartoletti, L. Gerratana, S. Zago, D. Basile, M.G. Vitale, G. Pelizzari, M. Bonotto, C. Bozza, V. Fanotto, C. Lisanti, M. Cinausero, S. Barban, M. Lera, I. Venuti, M. Mansutti, A.M. Minisini, G. Fasola, F. Curcio, F. Puglisi
Journal: Annals of Oncology (2017)
Differentiation of two distinct clusters among currently circulating influenza A(H1N1)v viruses, March-September 2009
Authors: S R Fereidouni, M Beer, T Vahlenkamp, E Starick
Journal: Eurosurveillance (2009)

Analysis of all complete genome sequences of the pandemic influenza A(H1N1)v virus available as of 10 September 2009 revealed that two closely related but distinct clusters were circulating in most of the affected countries at the same time. The characteristic differences are located in genes encoding the two surface proteins - haemagglutinin and neuraminidase - and four internal proteins - the polymerase PB2 subunit, nucleoprotein, matrix protein M1 and the non-structural protein NS1. Phylogenetic inference was demonstrated by neighbour joining, maximum likelihood and Bayesian trees analyses of the involved genes and by tree construction of concatenated sequences.
Progress towards TB reduction targets is faltering, report finds
Authors: Sophie Cousins
Journal: BMJ (2017)

Less than half of the 10.4 million people who develop tuberculosis (TB) each year are being successfully treated, according to a new report.1

The 90-(90)-90 Tuberculosis Report for Heads of State and Governments, published by Stop TB Partnership, found that global progress towards reaching the “90-(90)-90” goals is faltering.

The 90-(90)-90 goals, as part of the Global Plan to End TB 2016-2020, aim to ensure that 90% of all people with TB have been diagnosed and receive treatment; 90% of the most vulnerable populations are diagnosed and treated; and 90% of those diagnosed successfully complete treatment by 2020.

But according to the report, no country has achieved both 90% treatment coverage and 90% …
Your Hearing: How to Preserve and Aid It.
Authors: Wendell Christopher Phillips, Hugh Grant Rowell
Journal: JAMA (1933)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulating ESR1 mutations at the end of aromatase inhibitor adjuvant treatment and after relapse in breast cancer patients
Authors: V. Allouchery, L. Beaussire, A. Perdrix, D. Sefrioui, L. Augusto, C. Guillemet, N. Sarafan-Vasseur, F. Di Fiore, F. Clatot
Journal: Annals of Oncology (2017)
Safety and efficacy of Cabozantinib for metastatic renal cell carcinoma (mRCC): real world data from an Italian Expanded Access Program (EAP)
Authors: G. Procopio, M. Prisciandaro, R. Iacovelli, M. Mancini, G. Fornarini, G. Facchini, G. Cartenì, M. Napolitano, C.N. Sternberg, C. Caserta, M. Bregni, F. Massari, S. Buti, E. Biasco, U. De Giorgi, F. Zustovich, R. Ratta, C. Ortega, G. Tortora, E. Verzoni
Journal: Annals of Oncology (2017)
Benefit of the use of tyrosine kinase inhibitors (TKIs) in patients (pts) with METAstatic Soft Tissue SARComa (STS) in a Real-Life Setting: an ancillary analysis of the METASARC Study
Authors: S. Cousin, M. Savina, A. Le Cesne, J.-Y. Blay, I. Ray-Coquard, O. Mir, M. Toulmonde, P. Terrier, D. Ranchere-Vince, P. Meeus, E. Stoeckle, C. Honore, P. Sargos, M.P. Sunyach, C. Le Pechoux, A. Giraud, C. Bellera, F. le loarer, A. Italiano
Journal: Annals of Oncology (2017)
Immune correlates for the efficacy of PEGylated Human IL-10 (AM0010) with nivolumab in renal cell cancer
Authors: A. Naing, J.R. Infante, D.J. Wong, M.W. Korn, R. Aljumaily, K. Papadopoulos, K. Autio, S. Pant, T.M. Bauer, A. Drakaki, N. Daver, A. Hung, P. Van Vlasselaer, G. Brown, M. Oft, N. Tannir
Journal: Annals of Oncology (2017)
Nutritional risk as a predictor of short-term outcomes in a prospective cohort of elderly patients with cancer
Authors: L.T. Sales, J.T. Oliveira Lima, A. Bergmann, M.J.G. Mello, M. Rebello, Z. Cavalcanti, D. Sales, N. Cruz, L.C.S. Thuler
Journal: Annals of Oncology (2017)
David Oliver: How much information should patients’ families expect on acute wards?
Authors: David Oliver
Journal: BMJ (2017)

One of the biggest stressors in work for me and my colleagues, junior and senior, is the relentless demand for information—not from patients themselves but from their relatives.

It’s taboo to talk about this in public for fear of appearing callous and uncaring. But it comes up whenever a group of medics unburden themselves in a safe space. I’m happy to break the taboo and to be found wanting for doing so.

The source of this stress is rarely visitors who are involved carers, supporting the patient day in, day out. They are often highly present on the wards, making frequent interaction and updates easier. It’s crucial to involve …
Immune expression profile and sunitinib benefit in metastatic clear cell renal cell carcinoma (ccRCC)
Authors: O. Reig Torras, M. Marín-Aguilera, N. Jimenez, L. Paré, P. Galvan, C. Mallofre, A. Prat, B. Mellado Gonzalez
Journal: Annals of Oncology (2017)
Time out: ethical reflections on medical disqualification of athletes in the context of mandated pre-participation cardiac screening
Authors: Emma Forton Magavern, Gherardo Finocchiaro, Sanjay Sharma, Michael Papadakis, Pascal Borry
Journal: British Journal of Sports Medicine (2017)

Sudden cardiac death (SCD) in any young person is a tragic event.Following decades of high profile cases, the value of preventative strategies, including cardiac preparticipation screening for athletes, has been debated in the medical community and public health arena.Equally important, but less prominent in the literature, are the possible implications of subsequent disqualification of individuals identified with a condition associated with exercise related SCD from competitive sports.This is critical, given the currently limited knowledge regarding the risk of exercise induced malignant arrhythmias for heterogeneous conditions, poor risk stratification protocols in athletic individuals, and the potential benefits of disqualification in reducing morbidity and mortality.These challenges are reflected in the discrepancies of expert consensus recommendations across the Atlantic.In recognition of the limited evidence, the American Heart Association and the American College of Cardiology take a more liberal approach, while the European Society of Cardiology makes more conservative recommendations.This analysis considers the ethical implications of disqualification of athletes with heart disease from competitive sports in the context of available evidence, contemporary medical recommendations and legal structures, as well as emerging genetic diagnostics.
Concurrent chemoradiotherapy (CCRT) versus induction docetaxel, cisplatin and 5-fluorouracil (TPF) followed by CCRT in locally advanced hypopharyngeal and base of tongue cancer: A randomized phase II study
Authors: S.H. Lim, J-M. Sun, J. Hong, D. Oh, Y.C. Ahn, M.K. Chung, H-S. Jeong, Y-I. Son, M-J. Ahn, C-H. Baek, K. Park
Journal: Annals of Oncology (2017)
Cancer cachexia (CAX), anorexia and muscle wasting (sarcopenia) assessment in non-small cell lung cancer (NSCLC): an observational study in 531 patients
Authors: D. Debieuvre, H. Morel, P-J. Souquet, V. Surmont, D. Planchard, F. Bonnetain, I. Krakowski, H. Gaudin, S. Antoun
Journal: Annals of Oncology (2017)
Abstract 17736: ICD Lead Performance in Athletes: Long-term Results of a Prospective Multinational Registry
Authors: Mark S Link, Brian Olshansky, David Cannom, Charlie I Berul, Robert G Hauser, Hein Heidbuchel, Luc Jordaens, Andrew D Krahn, Kristen K Patton, Elizabeth Saarel, Bruce L Wilkoff, Fangyong Li, James Dzuira, Laura Simone, Cynthia Brandt, Cheryl Barth, Rachel Lampert
Journal: Circulation (2016)

Background:  Athletic activity, especially including those with repetitive upper extremity motion, may increase the risk of lead failure in those with an implanted defibrillator (ICD). A prospective international registry has followed athletes with ICDs. The current study is an analysis of this registry focusing on lead failures.   Hypothesis:  Lead failures will be increased in those participating in sports.   Methods:  Athletes with transvenous ICDs (age 10-60 years) participating in sports were enrolled in a prospective international registry. Contact sports were defined based on American Academy of Pediatrics definitions. Clinical outcomes including lead failure (nonphysiologic noise or significant changes in sensing or pacing) were adjudicated by two electrophysiologists.   Results:  The registry enrolled 440 athletes with an ICD. Median age was 33 years (111    Conclusions:  Overall lead failure rate in non-recalled leads (89.0%% over ten years) is similar to that reported in the general population. In this cohort of 440 athletes, intense arm activity and contact sports did not predict lead failure compared to those not engaged in these activities.
Improved Bone Microarchitecture in Patients With Celiac Disease After 3 Years on a Gluten-Free Diet
Authors: María B. Zanchetta, Ana F. Costa, Vanesa Longobardi, Roberto Mazure, Fernando Silveira, María P. Temprano, Horacio Vázquez, César Bogado, Sonia I. Niveloni, Edgardo Smecuol, María L. Moreno, Andrea González, Eduardo Mauriño, José R. Zanchetta, Julio C. Bai
Journal: Clinical Gastroenterology and Hepatology (2017)
Functional screening of B7H6-based chimeric antigen receptor (CAR) designs
Authors: B. Demoulin, L. Springuel, D. Daro, J. Bolsée, J. Houssa, F. Huberty, C. Jacques-Hespel, C. Marchand, J. Marijsse, T.L.T. Nguyen, N. Ramelot, B. Violle, C. Lonez, D.E. Gilham, V. Steenwinckel
Journal: Annals of Oncology (2017)
Achievement of complete response (CR) in metastatic or recurrent cervical cancer (MRCC): Does it matter?
Authors: J.F. Grau Béjar, V. Rodriguez Freixinos, L. Fariñas Madrid, G. Villacampa, A. Gil, R. Verges, M.A. Perez Benavente, A. García, R. Dienstmann, A. Oaknin
Journal: Annals of Oncology (2018)
Comparison of carboplatin with 5-fluorouracil (carbo-5FU) versus cisplatin as concomitant chemoradiotherapy (CRT) for locally advanced head and neck squamous cell carcinoma (LA-HNSCC)
Authors: S.H. Hanemaaijer, I.C. Kok, R.S.N. Fehrmann, B. van der Vegt, J.A. Gietema, B.E.C. Plaat, M.A.T.M. Vugt, M.R. Vergeer, J. Voortman, C.R. Leemans, J. Buter, J.A. Langendijk, S.F. Oosting
Journal: Annals of Oncology (2017)
Death by Gun Violence—A Public Health Crisis
Authors: Howard Bauchner, Frederick P. Rivara, Robert O. Bonow, Neil M. Bressler, Mary L. (Nora) Disis, Stephan Heckers, S. Andrew Josephson, Melina R. Kibbe, Jay F. Piccirillo, Rita F. Redberg, John S. Rhee, June K. Robinson
Journal: JAMA Pediatrics (2017)
Phase I dose escalation study of the protein kinase C iota inhibitor aurothiomalate for advanced non-small cell lung cancer, ovarian cancer, and pancreatic cancer.
Authors: Aaron Scott Mansfield, Alan P. Fields, Aminah Jatoi, Yingwei Qi, Alex A. Adjei, Charles Erlichman, Julian R. Molina
Journal: Journal of Clinical Oncology (2013)

2551 Background: Protein kinase C iota (PKCi) is overexpressed in non-small cell lung (NSCLC), ovarian and pancreatic cancers and promotes tumorigenesis. The gold compound aurothiomalate (ATM) inhibits downstream activation of Rac1 by PKCi. We sought to determine the maximum tolerated dose (MTD) of ATM. Methods: We conducted a phase I dose escalation trial of ATM in patients with NSCLC, ovarian or pancreatic cancer. In the dose escalation cohort patients received ATM IM weekly for three cycles (cycle duration 4 weeks) at 25 mg, 50 mg or 75 mg in a 3+3 design. The dose was not escalated for individual patients. Up to 9 subjects were allowed to enroll in the expansion cohort at the MTD. Blood samples were analyzed for elemental gold levels. Patients were evaluated for response every eight weeks with computed tomography using modified response evaluation criteria in solid tumors. Results: Fifteen patients, all pretreated, enrolled in this study. There were ten patients with NSCLC, four with ovarian cancer and one with pancreatic cancer. Six patients were treated at the 25 mg dose, 6 patients at 50 mg, and 2 at 75 mg. There was 1 dose limiting toxicity (DLT) at 25 mg (hypokalemia), 1 DLT at 50 mg (urinary tract infection), and none at 75 mg. There were 3 grade 3 hematologic toxicities in the dose escalation cohort. The recommended MTD of ATM is 50 mg, and 1 subject was treated in the expansion cohort at 50 mg. Patients received treatment for a median of 2 cycles (range 1-3). The best response observed was stable disease in 2 subjects. There appeared to be a dose-related accumulation of steady-state plasma concentrations of gold with concentrations exceeding 20 µM after one month of therapy with 75 mg of ATM and after 2 months of therapy with 50 mg of ATM, consistent with linear pharmacokinetics. Conclusions: In summary, this phase I study was successful in identifying ATM 50 mg IM weekly as the MTD. In this heavily pre-treated group of patients in who we observed at best stable disease, it remains unclear whether future investigations that target PKCi should focus on single agent ATM, combination therapy with ATM, or other PKCi inhibitors that are currently in development. Clinical trial information: NCT00575393.
Using Antimüllerian Hormone to Predict Fertility
Authors: Nanette Santoro
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 16607: Human Pharmacokinetics of Centhaquin Citrate, a Novel Resuscitative Agent
Authors: Anil Gulati, Ashish O Goyal, Manish S Lavhale, Shruti Gulati, Marc Scheetz
Journal: Circulation (2016)

Introduction: Centhaquin citrate (PMZ-2010) is a novel agent that has been shown to reduce blood lactate, increase cardiac output and mean arterial pressure, and decrease vascular resistance in hem...
Palliative care in interstitial lung disease: living well
Authors: Michael Kreuter, Elisabeth Bendstrup, Anne-Marie Russell, Sabrina Bajwah, Kathleen Lindell, Yochai Adir, Crystal E Brown, Greg Calligaro, Nicola Cassidy, Tamera J Corte, Klaus Geissler, Azza Adel Hassan, Kerri A Johannson, Ronaldo Kairalla, Martin Kolb, Yasuhiro Kondoh, Sylvia Quadrelli, Jeff Swigris, Zarir Udwadia, Athol Wells, Marlies Wijsenbeek
Journal: The Lancet Respiratory Medicine (2017)