tbuckley/cabot-search huggingface dataset:
Prevalence and incidence of interstitial lung diseases in a multi-ethnic county of Greater Paris
Authors: Boris Duchemann, Isabella Annesi-Maesano, Camille Jacobe de Naurois, Shreosi Sanyal, Pierre-Yves Brillet, Michel Brauner, Marianne Kambouchner, Sophie Huynh, Jean Marc Naccache, Raphael Borie, Jacques Piquet, Arsène Mekinian, Jerôme Virally, Yurdagul Uzunhan, Jacques Cadranel, Bruno Crestani, Olivier Fain, Francois Lhote, Robin Dhote, Nathalie Saidenberg-Kermanac'h, Paul-André Rosental, Dominique Valeyre, Hilario Nunes
Journal: European Respiratory Journal (2017)

The objective of the study was to estimate the prevalence and incidence of interstitial lung diseases (ILDs) in Seine-Saint-Denis, a multi-ethnic county of Greater Paris, France.Patients with ILDs were identified between January and December 2012 by using several sources; all potentially involved medical specialists from public and private hospitals, community-based pulmonologists and general practitioners, and the Social Security system. Diagnoses were validated centrally by an expert multidisciplinary discussion.1170 ILD cases were reported (crude overall prevalence: 97.9/105 and incidence: 19.4/105/year). In the 848 reviewed cases, the most prevalent diagnoses were sarcoidosis (42.6%), connective tissue diseases associated ILDs (CTDs-ILDs) (16%), idiopathic pulmonary fibrosis (IPF) (11.6%), and occupational ILDs (5.0%), which corresponded to a crude prevalence of 30.2/105 for sarcoidosis, 12.1/105 for CTDs-ILDs and 8.2/105 for IPF. The prevalence of fibrotic idiopathic interstitial pneumonias, merging IPF, nonspecific interstitial pneumonia and cases registered with code J84.1 was 16.34/105 An adjusted multinomial model demonstrated an increased risk of sarcoidosis in North Africans and Afro-Caribbeans and of CTDs-ILDs in Afro-Caribbeans, compared to that in Europeans.This study, with a comprehensive recruitment and stringent diagnostic criteria, emphasises the importance of secondary ILDs, particularly CTDs-ILDs and the relatively low prevalence of IPF, and confirms that sarcoidosis is a rare disease in France.
Lymphoma Causing Gastrosplenic Fistula Revealed by FDG PET/CT
Authors: Trent P. Wang, Mohan Doss, Jeffrey L. Tokar, Sanjay Reddy, Stefan K. Barta, Jian Q. Yu
Journal: Clinical Nuclear Medicine (2017)

A 73-year-old man presented with fatigue and weight loss. He had CT-proven splenic mass with fistulous connection to the greater curvature of the stomach, which suggested abscess. FDG PET/CT confirmed gastrosplenic fistula in addition to active lymph nodes in the gastrohepatic ligament and epigastric region. Pathological examination after the biopsy of the spleen was consistent with diffuse large B-cell lymphoma. Chemotherapy was administered with close clinical follow-up and resulted in the resolution of fistula without requirement for surgery.
piRNA分子ビーコンを用いた単一乳癌細胞におけるpiRNA分子経路調節theragnostic効果の多重バイオイメージング【Powered by NICT】
Authors: Lee Youn Jung, Moon Sung Ung, Park Min Geun, Jung Woon Yong, Park Yong Keun, Song Sung Kyu, Ryu Je Gyu, Lee Yong Seung, Heo Hye Jung, Gu Ha Na, Cho Su Jeong, A Ali Bahy, A Al-Khedhairy Abdulaziz, Lee Ilkyun, Kim Soonhag
Journal: Biomaterials (2016)
Facts Concerning Duexis Prescribing Habits Related to Combination Therapies—Reply
Authors: Aaron Hakim, Joseph S. Ross
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
02.36 Lasp-1 regulates the migratory behaviour of synovial fibroblasts in rheumatoid arthritis
Authors: Denise Beckmann, Annika Krause, Uwe Hansen, Hans P. Kiener, Karolina von Dalwigk, Thomas Kamradt, Catherine Chew, Thomas Pap, Adelheid Korb-Pap
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> In rheumatoid arthritis (RA) the attachment of synovial fibroblasts to articular cartilage is an important prerequisite in the process of cartilage degradation. The actin-associated protein Lasp-1 is involved in processes of actin organisation and polymerization and focal adhesion turnover, respectively. Therefore, we investigated its role in regulating cell-cell contacts and ECM interactions of synovial fibroblasts in RA. <h3>Methods</h3> Lasp-1 expression was analysed in human RA tissue and in arthritic mouse models such as the hTNFtg and G6PI mouse model by using WB and immunohistochemistry. Lasp-1 expression and its subcellular distribution was investigated in isolated synovial fibroblasts by immunofluorescence in all genotypes. Furthermore, the formation of cell-cell and -ECM contacts was investigated in an electrical cell/substrate impedance sensing assay (ECIS) as well as by immunofluorescence. Additionally, we performed an <i>in vitro</i> three-dimensional organ culture system to identify genotype-specific differences of cellular distribution and formation of the artificial synovial lining layer. <h3>Results</h3> An increased Lasp-1 expression was observed in synovial tissue from RA patients as well as in RASF. Isolated SF from hTNFtg mice also produced higher levels of Lasp-1 compared to wild type (wt) SF. Interestingly, this was completely reproducible in the G6PI model. Lasp-1 deficient mice that had been crossed into the hTNFtg background exhibited less cartilage degradation (−4% vs. hTNFtg) and less attachment of synovial tissue to the cartilage (−30% vs. hTNFtg) compared to hTNFtg mice. Functional analyses indicated that Lasp-1<sup>-/-</sup> hTNFtg SF form closer (+20% vs hTNFtg SF) and more stable cell-cell contacts in comparison to hTNFtg SF. Furthermore, we detected Lasp-1 to be located at structures of adherens junction complexes. The loss of Lasp-1 led to alterations of these structures. Histological analysis of 3D matrices showed that Lasp-1 deletion in the hTNFtg background resulted in an organised cellular lining layer at the interface between the matrix and fluid phases comparable with wild type SF. In contrast, hTNFtg SF formed unorganised cellular condensations with no synovial architecture evident. <h3>Conclusions</h3> Lasp-1 regulates the migratory behaviour of synovial fibroblasts and their invasion into cartilage matrix in rheumatoid arthritis by controlling the dynamics of cell-cell contacts.
OC-015 Impact and cost effectiveness of formal gastroenterology outpatient referral clinical assessment service
Authors: S Pelitari, C Hathaway, D Gritton, A Smith, D Bush, B McKaig
Journal: Gut (2017)

Introduction  In 2012–13 gastroenterology (GI) services at Royal Wolverhampton NHS Trust (RWT) faced a 25% increase in new outpatient GI referrals. Therefore we collaborated with the Wolverhampton CCG to develop “Clinical Assessment Service” (CAS); a new model of working to improve efficiency of our GI referral pathways and reduce total costs to the healthcare economy whilst delivering an improved service to our patients. CAS allows secondary care clinicians to triage patients referred by GPs to the most appropriate pathway in a timely manner. We now present data from the first 3 years of the Gastroenterology CAS triage system at RWT.  Method  An electronic CAS proforma and a data platform were developed. Five potential outcomes were identified for each patient. Pathways for the 5 most common referral indications were also introduced. Satisfaction surveys for GPs and patients were performed after the first year. Data were analysed retrospectively focusing on patient outcome decision and impact on departmental performance and finances.  Results  A total of 14245 GP referrals were received between January 2014 and December 2016 with 9773 of them being triaged via our CAS service. A new outpatient appointment was offered to 60.1% (n=5873) of the CAS referred patients either as a fast track, urgent or routine slot with 23.8% (n=2326) of them having bloods arranged prior to their appointment. Endoscopic or radiological investigations were requested for 29.2% (n=2854) of patients prior to deciding on further management plan. Out of those, 27% (n=765) went on to receive another GI clinic appointment. The remaining 21.3% (n=2089) of this group were discharged back to their GP following initial investigations. 5.5% (n=538) were discharged to primary care with a letter of advice while 5.2% (n=509) were deemed inappropriate for GI clinic and were redirected to other specialists. Overall, 32% (n=3127) of patients were managed without a face to face consultation in the GI clinic. For the 3 year period of delivering the service this corresponds to 446 new outpatient clinics and estimated financial savings to health economy of £331K. 18 week performance and waiting times remained stable despite the increasing referral population. The DNA rate dropped from 14% pre to 8.5% post CAS implementation.  Conclusion  32% of CAS triaged patients were discharged in primary care with letter of advice without need of GI appointment which corresponds to savings equal to £331K. DNA rates were low and patients’ feedback very positive. Through our experience with CAS we are able to demonstrate that our new model of clinical assessment for GI referrals has in addition to the clinical benefits, a considerable positive financial impact to the health economy.  Disclosure of Interest  None Declared
GNPAT p.D519G is Independently Associated with Markedly Increased Iron Stores in HFE p.C282Y Homozygotes
Authors: James C. Barton, Wen-Pin Chen, Mary J. Emond, Pradyumna D. Phatak, V. Nathan Subramaniam, Paul C. Adams, Lyle C. Gurrin, Gregory J. Anderson, Grant A. Ramm, Lawrie W. Powell, Katrina J. Allen, John D. Phillips, Charles J. Parker, Gordon D. McLaren, Christine E. McLaren
Journal: Blood (2016)
Efficacy of curettage alone for invasive cutaneous squamous cell carcinoma: A retrospective cohort study
Authors: Kara Yakish, Jove Graham, Eric W. Hossler
Journal: Journal of the American Academy of Dermatology (2017)

To the Editor: Treatment modalities for invasive cutaneous squamous cell carcinoma (icSCC) include electrodessication and curettage, standard excision, and Mohs micrographic surgery.1 Electrodessication provides hemostasis. However, its use has been associated with hypopigmentation, hypertrophic scarring, and delayed healing.2 In addition, literature confirming its direct contribution to tumor extirpation is lacking.2 Curettage without electrodessication of basal cell carcinomas has been documented to be as effective as electrodessication and curettage,2,3 and some providers within our group subsequently adopted this technique for treating icSCC.
Neuronal Interfaces: Interactions of Neurons with Physical Environments (Adv. Healthcare Mater. 15/2017)
Authors: Michal Marcus, Koby Baranes, Matthew Park, Insung S. Choi, Kyungtae Kang, Orit Shefi
Journal: Advanced Healthcare Materials (2017)

In Progress Report 1700267, Orit Shefi and co-workers exploit studies of platforms generated with a range of physical topographies, from micro- down to nano- scale, that interact effectively with neurons, affecting differentiation, outgrowth and activity. Matching these specific needs may advance therapies and brain-machine interface applications.
Optical Coherence Tomography Characterization of Coronary Lithoplasty for Treatment of Calcified Lesions
Authors: Ziad A Ali, Todd J Brinton, Jonathan M Hill, Akiko Maehara, Mitsuaki Matsumura, Keyvan Karimi Galougahi, Uday Illindala, Matthias Götberg, Robert Whitbourn, Nicolas Van Mieghem, Ian T Meredith, Carlo Di Mario, Jean Fajadet
Journal: JACC. Cardiovascular imaging (2017)
03.01 Adipokines as link between arthritis and metabolism
Authors: Marie-Lisa Hülser, Carina Schreiyäck, Yubin Luo, Aline Bozec, Georg Schett, Ulf MüllerLadner, Elena Neumann
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> The important role of adipokines in obesity and hyperinsulinemia is well characterised. Furthermore, the adipokines adiponectin, visfatin and leptin are known to be immunomodulatory factors in the context of rheumatic diseases. Since hyperinsulinemia and obesity are widespread comorbidities of osteoarthritis (OA), the combination of an OA model (surgical destabilisation of the medial meniscus (DMM)) with hyperinsulinemia and obesity through high-fat diet (HFD) is an obvious consequence. Here we evaluated and correlated systemic vs. local effects of adipokines in OA with normal diet (ND) compared to HFD. <h3>Materials and methods</h3> Hyperinsulinemia and obesity in C57Bl/6 mice was induced by HFD containing mainly saturated fatty acids. The control group was fed with ND. Both groups underwent surgical OA induction. Mice were sacrificed 4, 6 and 8 weeks after OA induction. Systemic levels of adiponectin, leptin, visfatin and IL-6 were measured by serum ELISA. Mouse joints were paraffin embedded and stained histologically (H/E, safranin O, pappenheim and Masson-Goldner's trichrome) and local macrophage and adipokine distributions were evaluated by immunohistochemical staining. <h3>Results</h3> To exclude acute inflammation as a consequence of the surgery, we confirmed normal levels of IL-6 in all animals. Histological scoring of the mice confirmed OA induction in DMM mice, which was increased when DMM was combined with HFD. Systemic leptin levels were significantly elevated by HFD at all timepoints, but DMM led to a decrease in leptin (3/6 groups significant, e.g. 4 weeks HFD healthy 86.9±17 ng/ml vs. DMM 25.8±15.6 ng/ml). Systemic levels of visfatin, adiponectin and IL-6 did not show strong reactions to diet. Noteworthy, adiponectin was systemically increased by OA induction, but only 8 weeks after surgery (e.g. HFD healthy 6148.65±637.64 ng/ml vs. HFD healthy 5175.95±417.74 ng/ml). <h3>Conclusions</h3> OA induced by DMM was aggravated when combined with HFD. Leptin levels in the mouse sera were elevated by HFD but reduced by DMM, which could not be observed for visfatin. Adiponectin seems to play a role in later stages of OA development, since it was solely elevated in later stages of OA. The results show that systemic levels of adipokines can be influenced by DMM and/or HFD.
Clinical Outcomes With a Repositionable Self-Expanding Transcatheter Aortic Valve Prosthesis
Authors: Eberhard Grube, Nicolas M. Van Mieghem, Sabine Bleiziffer, Thomas Modine, Johan Bosmans, Ganesh Manoharan, Axel Linke, Werner Scholtz, Didier Tchétché, Ariel Finkelstein, Ramiro Trillo, Claudia Fiorina, Antony Walton, Christopher J. Malkin, Jae K. Oh, Hongyan Qiao, Stephan Windecker, Eberhard Grube, Stephan Windecker, Johan Bosmans, Sabine Bleiziffer, Ganesh Manoharan, Thomas Modine, Nicolas Van Mieghem, Ajay Sinhal, Robert Gooley, Tony Walton, Gerald Yong, Johan Bosmans, John Webb, Michael Chu, Sam Radhakrishnan, Antonio Dager, Marian Branny, Didier Tchetche, Thomas Modine, Emmanuel Teiger, Bernard Chevalier, Dominique Himbert, Gerhard Schymik, Tobias Zeus, Christoph Jensen, Tienush Rassaf, Stephan Fichtlscherer, Georg Nickenig, Axel Linke, Sabine Bleiziffer, Jörg Kempfert, Werner Scholtz, Axel Harnath, Ruth Strasser, Christian Frerker, Konstantinos Spargias, Béla Peter Merkely, Ariel Finkelstein, Corrado Tamburino, Antonio Colombo, Anna Sonia Petronio, Claudia Fiorina, Francesco Bedogni, Giovanni Amoroso, Jan van der Heijden, Nicolas Van Mieghem, Pim Tonino, Pedro Echeverria Beliz, Adam Witkowski, Vasco Gama Ribeiro, Moheeb Al Abdullah, Hellmuth Weich, Ramiro Trillo, José Maria Hernández García, Cesar Moris, Anders Lars Jönsson, Christopher J. Malkin, Saib Khogali, David Hildick-Smith, Ganesh Manoharan
Journal: Journal of the American College of Cardiology (2017)
The EuroMyositis registry: an international collaborative tool to facilitate myositis research
Authors: James B Lilleker, Jiri Vencovsky, Guochun Wang, Lucy R Wedderburn, Louise Pyndt Diederichsen, Jens Schmidt, Paula Oakley, Olivier Benveniste, Maria Giovanna Danieli, Katalin Danko, Nguyen Thi Phuong Thuy, Monica Vazquez-Del Mercado, Helena Andersson, Boel De Paepe, Jan L deBleecker, Britta Maurer, Liza J McCann, Nicolo Pipitone, Neil McHugh, Zoe E Betteridge, Paul New, Robert G Cooper, William E Ollier, Janine A Lamb, Niels Steen Krogh, Ingrid E Lundberg, Hector Chinoy
Journal: Annals of the Rheumatic Diseases (2017)

Aims The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data. Methods Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. Results Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p&lt;0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p&lt;0.001). Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p&lt;0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p&lt;0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p&lt;0.001). ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p&lt;0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases (‘V’ sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p&lt;0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%. Conclusion This large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.
DECISION MAKING IN THE RETURN TO PLAY AND PREVENTION STRATEGIES – ANALYSIS OF ELITE FOOTBALL PLAYERS AND TEAM COACHE` VIEW
Authors: Werner Krutsch, Peter Angele, Michael Nerlich, Oliver Loose
Journal: British Journal of Sports Medicine (2017)

Background Football injuries are a common problem for players, coaches and clubs. To improve prevention strategies, the player and coach view needs to be known. Objective The aim of the study was to reveal current views about injuries prevention strategies in football. Design Retrospective cohort study in elite football level. Setting The elite football level of salaried football players (n=486) and team coaches (n=88) were investigated. Participants Team coaches (c) and male football players (p) of all age levels of the 4th until 6th division in German football were included. Interventions One questionnaire at the beginning of a football season was completed in the context of an intervention study regarding injury prevention in elite football. Main Outcome Measurements Investigated topics were points view about influencing factors on injuries, screening tests, injury profile and return to play decision-making. Results Physiotherapy (p:77.8%; c:75.9%) and screening examinations (p: 56.3%; c: 62.1%) were highest ranked as prevention strategy in football. The most important preventive training topics were warm up exercises (p: 76.1%; c: 74.7%), regeneration (p: 54.1%; c: 56.3%) and core stability (p: 53.8; c: 70.1%), while practical transfer to the field was low for core stability (p: 27.5%; c: 32.1%) and balancing exercises (p: 22.0; c: 19.8%). Knee injuries (p: 90.7%; c: 93.1%) were reported as the most common problem in football. Decision-making for return to play after injuries presented players with own will for a decision-making (81.4%) and the team coaches with the opinion that doctors are main decision maker (83.5%). Thus, decisions against doctors' recommendation in the past were frequently made among participants (p: 64.4%; c: 87.1%). Conclusions The basic knowledge about prevention of injuries in elite football is sufficient, while practical implementation is insufficient.
Seven day service doesn’t improve clinical outcomes, researchers find
Authors: Abi Rimmer
Journal: BMJ (2017)

Reorganising hospital services to create a seven day NHS would not improve clinical outcomes, researchers have concluded.

The paper, published in BMC Health Services Research , said that adverse clinical outcomes at the weekend might not be lessened by large scale reorganisation designed to create seven day services.1

In December 2012 NHS England outlined plans for seven day access of patients to NHS services.2 In 2013 the national medical director, Bruce Keogh, and his colleagues at …
デュアルモード画像誘導光線力学療法のためのスマートヒアルロニダーゼ明確になったセラノスティックミセル【Powered by NICT】
Authors: Li Wenjun, Zheng Cuifang, Pan Zhengyin, Chen Chi, Hu Dehong, Gao Guanhui, Kang Shendong, Cui Haodong, Gong Ping, Cai Lintao
Journal: Biomaterials (2016)