tbuckley/cabot-search huggingface dataset:
Abstract 9844: Endothelial Function is Impaired in Subjects With Increased Ratio of Serum Levels of AGEs to Soluble Form of RAGE
Authors: Masato Kajikawa, Yukihito Higashi, Ayumu Nakashima, Noritaka Fujimura, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi Iwamoto, Nozomu Oda, Shinji Kishimoto, Takayuki Hidaka, Kensuke Noma, Masayoshi Takeuchi, Takanori Matsui, Sho-ichi Yamagishi, Yasuki Kihara
Journal: Circulation (2015)

Introduction: Advanced glycation end products (AGEs) and their specific receptor, the receptor for AGEs (RAGE), play an important role in atherosclerosis. Recently, a soluble form of RAGE (sRAGE) has been identified in human serum. However, the role of sRAGE in cardiovascular disease is still controversial. There is no information on the association between simultaneous measurements of AGEs and sRAGE and vascular function. In this study, we evaluated the associations between serum levels of AGEs and sRAGE, ratio of AGEs to sRAGE and vascular function. Methods: We measured serum levels of AGEs and sRAGE and assessed vascular function by measurement of flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation in 110 subjects who underwent health examinations. Multivariate regression analyses were performed to identify factors associated with vascular function. Results: Univariate regression analysis revealed that FMD correlated with age (ρ=-0.38, P&lt;0.01), body mass index (ρ=-0.28, P&lt;0.01), systolic blood pressure (ρ=-0.44, P&lt;0.01), diastolic blood pressure (ρ=-0.46, P&lt;0.01), heart rate (ρ=-0.29, P&lt;0.01), triglycerides (ρ=-0.37, P&lt;0.01), high-density lipoprotein cholesterol (ρ=0.19, P&lt;0.05), glucose (ρ=-0.20, P&lt;0.05), smoking pack-years (ρ=-0.32, P&lt;0.01), nitroglycerine-induced vasodilation (ρ=0.40, P&lt;0.01), serum levels of AGEs (ρ=-0.34, P&lt;0.01) and sRAGE (ρ=0.20, P&lt;0.05), and ratio of AGEs to sRAGE (ρ=-0.38, P&lt;0.01). Multivariate analysis revealed that the ratio of AGEs to sRAGE remained an independent predictor of FMD (β=-0.22, P=0.03), while serum level of AGEs alone (β=-0.14, P=0.13) or sRAGE alone (β=0.13, P=0.15) was not associated with FMD. Conclusions: These findings suggest that sRAGE may have a counter-regulatory mechanism that is activated to counteract the vasotoxic effect of the AGEs-RAGE axis. The ratio of AGEs to sRAGE may be a new chemical biomarker of endothelial function.
Why do people believe in a zero-sum economy?
Authors: Samuel G. B. Johnson
Journal: Behavioral and Brain Sciences (2018)

Abstract Zero-sum thinking and aversion to trade pervade our society, yet fly in the face of everyday experience and the consensus of economists. Boyer &amp; Petersen's (B&amp;P's) evolutionary model invokes coalitional psychology to explain these puzzling intuitions. I raise several empirical challenges to this explanation, proposing two alternative mechanisms – intuitive mercantilism (assigning value to money rather than goods) and errors in perspective-taking.
Differential Distribution of Cardiac Ion Channel Expression as a Basis for Regional Specialization in Electrical Function
Authors: GernotSchram, MarcPourrier, PeterMelnyk, StanleyNattel
Journal: Circulation Research (2002)

The cardiac electrical system is designed to ensure the appropriate rate and timing of contraction in all regions of the heart, which are essential for effective cardiac function. Well-controlled cardiac electrical activity depends on specialized properties of various components of the system, including the sinoatrial node, atria, atrioventricular node, His-Purkinje system, and ventricles. Cardiac electrical specialization was first recognized in the mid 1800s, but over the past 15 years, an enormous amount has been learned about how specialization is achieved by differential expression of cardiac ion channels. More recently, many aspects of the molecular basis have been revealed. Although the field is potentially vast, an appreciation of key elements is essential for any clinician or researcher wishing to understand modern cardiac electrophysiology. This article reviews the major regionally determined features of cardiac electrical function, discusses underlying ionic bases, and summarizes present knowle...
Mulibrey Heart Disease
Authors: MaritaLipsanen-Nyman, JaakkoPerheentupa, JuhaniRapola, AnssiSovijärvi, MarkkuKupari
Journal: Circulation (2003)

Background— Mulibrey nanism is a rare inherited disease characterized by growth failure and multiorgan manifestations, including constrictive pericarditis. Its long-term course, the results of pericardiectomy, and the details of myocardial involvement have not been reported previously. Methods and Results— We studied 49 patients (26 men) born before 1985 and followed for up to 25 years. By 1999, 25 patients (51%) had developed congestive heart failure (CHF), 19 (39%) had undergone pericardiectomy for constrictive pericarditis, 10 (22%) had died of cardiac causes, and 5 (10%) had died of noncardiac causes. Of the 19 pericardiectomized patients, 12 derived lasting clinical benefit, whereas 1 patient suffered an early noncardiac death and 6 died later of unrelieved or recurrent CHF. At echocardiography in 34 living patients, left ventricular mass adjusted for body height and weight averaged (±SEM) 149±5 g in 21 unoperated patients, 144±8 g in 13 pericardiectomized patients, and 104±7 g in 16 healthy persons ...
Dual SPECT Imaging of Löffler’s Endomyocarditis in the Acute Phase
Authors: TomoyukiYamaguchi, YoshioYasumura, SatoshiNakatani, NoritoshiNagaya, HatsueIshibashi-Ueda, MasayukiInubushi, YoshioIshida, MasakazuYamagishi
Journal: Circulation (2000)
Abstract MP17: Fruits and Vegetables Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies
Authors: LeaBorgi, JohnForman
Journal: Circulation (2015)

Introduction: Intake of fruits and vegetables lower blood pressures in short-term interventional studies. However, data on the association of long-term intake of fruits and vegetables with hypertension risk are scarce. Hypothesis: We assessed the hypothesis that a higher long-term intake of fruits and vegetables is associated with a lower incidence of hypertension when compared with minimal intake of fruits and vegetables. Methods: We prospectively examined the independent association of fruit and vegetable intake with incident hypertension in three large longitudinal cohort studies of originally non-hypertensive individuals: Nurses’ Health Study I (NHS1, n=62,273, aged 38-63 years in 1984), Nurses’ Health Study II (NHS2, n=88,831, aged 27-44 years in 1991), and Health Professionals Follow-up Study (HPFS, n =37,414, aged 40-75 years in 1986). Information about diet (using a validated food frequency questionnaire), other risk factors and behaviors, and health status was updated biennially. We used multivar...
Abstract 105: The Therapeutic Efficacy of Embryonic Stem Cell-Derived Exosomes for Postinfarction Myocardial Repair and Regeneration
Authors: ErinLambers, VeronicaRamirez, AlexMackie, SolMisener, EnedaHoxha, PrasannaKrishnamurthy, SureshVerma, MelissaThal, RajGupta, RajKishore
Journal: Circulation Research (2012)

Although embryonic stem cells (ESCs) hold great promise for regeneration of the heart post myocardial infarction (MI) due to their pluripotent potential, it is this same potential that poses risk for the formation of teratomas. Lately there have been reports that exosomes, 30-100nm membrane bound vesicles, are not simply used by the cell to exocytose unwanted material, but contain intact protein, mRNA, and miRNA important for intercellular communication. Here we hypothesize that ESC derived exosomes can be used to exploit an already established mechanism to shuttle ESC content intercellularly in a cell free system for physiological and anatomical repair of the myocardium following acute myocardial infarction. To test our hypothesis exosomes were isolated by ultracentrifugation from equal numbers of murine ESCs or primary embryonic fibroblasts (MEFs). ESC exosomes had intact pluripotent transcripts similar to their parent cells in contrast the MEF exosomes. Using a double blinded acute myocardial infarctio...
Abstract 15907: Does Fractional Flow Reserve Truly Identify Coronary Stenoses Causing Myocardial Ischemia?
Authors: Giulia Arena, Alberto Morello, Antonello D’Andrea, Paolo Calabrò, Bernardino Tuccillo, Francesco Punzo, Fortunato Scotto di Uccio, Wanda Acampa, Roberta Assante, Emilia Zampella, Alberto Cuocolo, Paolo Golino
Journal: Circulation (2015)

Background: Despite the clinical importance of coronary physiological assessment, the relationship between coronary flow reserve (CFR) and fractional flow reserve (FFR) remains poorly defined. Hypothesis: We aimed at studying the relationship between absolute CFR and FFR in patients with stable coronary artery disease (CAD). Methods: Twenty-six patients with moderate (30%-70%) pretest likelihood of CAD underwent 82Rb PET/CT cardiac imaging at rest and after pharmacological stress (dipyridamole 0.142 mg/kg/min for 4 min). CFR was considered abnormal if ≤1.74. Patients then underwent coronary angiography and FFR was measured during intracoronary administration of adenosine (200 μg). FFR was considered abnormal if ≤0.8. A total of 30 stenoses were studied. Results: A significant, albeit modest, correlation exists between CFR and FFR (r=0.44, p=0.02). In particular, of the 16 stenoses with a pathological FFR value ≤0.8, only 6 showed a reduced CFR (black dots), while the other 10 had a normal CFR (red dots); in contrast, of the 14 lesions with an FFR value above 0.8, only one showed a reduced CFR (red dot), while the other 13 had a normal CFR (black dots). Conclusions: In this preliminary series, FFR values &gt;0.8, indicating a non-significant stenosis, show an excellent correlation with absolute CFR, while pathological FFR values (&lt;0.8) poorly correlate with a reduced CFR. This discordance should be probably taken into account when facing the choice of recommending revascularization solely on the basis of FFR values.
Abstract 4308: RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses
Authors: lesetja R. Motadi, pontsho Moela
Journal: Cancer Research (2018)

Abstract Breast cancer incidence rate has increased beyond that of lung cancer, making it the most common malignancy among women. Breast tumour progression is partly as a result of p53 inactivation by overexpressed ubiquitous regulatory proteins that possess p53 binding domain. RBBP6 forms a member of such protein since it has an E3 ligase activity due to its RING finger-like domain. Moreover, its overexpression in several malignancies makes it a potential target in cancer management. However, it is not clearly defined whether RBBP6 effect on cell growth and apoptosis is cell line dependent, more especially in breast cancer cell lines that have distinct p53 expression profiles. The present study therefore aims at evaluating RBBP6 effects on cell growth and apoptosis in breast cancer cell lines with different p53 expression profiles. Following analysis at mRNA and protein levels in breast cancer tissue, RBBP6 expression was successfully manipulated using gene silencing and protein overexpression techniques in MCF-7 and MDA-MB-231 cell lines. Transfection efficiencies were confirmed using qPCR and western blot, followed by monitoring of cell proliferation in the presence of transfection using xCELLigence system. The cells were then co-treated with anti-cancer agents followed by apoptosis detection using confocal microscopy and flow cytometry, which was further confirmed by caspase 3/7 activity and quantification of apoptotic genes. RBBP6 was overexpressed in breast cancer tissues that were classified as stage 3 and 4 while in stage 1 it was expressed but at much lower levels. The wt. p53-expressing MCF-7 cell line was more susceptible to apoptosis induction as opposed to the mt. p53-expressing MDA-MB-231. RBBP6 silencing led to a significant accumulation of p53 expression in MCF-7 as compared to MDA-MB-231. Co-treatment with GABA and camptothecin seemed to sensitize the cells to apoptosis induction. These data suggest that RBBP6 silencing triggers significant levels of intrinsic apoptosis and over-expression appears to promote cell proliferation in wild type p53-expressing MCF-7 rather than in MDA-MB-231 cells. Insignificant changes in the expression of mt. TP53 in MDA-MB-231 cell line following RBBP6 silencing and over-expression suggests that RBBP6 is highly likely to interact with wt-p53 rather than mutated p53. In conclusion, the effect of RBBP6 on cell proliferation and apoptosis induction in breast cancer seem to be cell line dependent based on p53 status Citation Format: lesetja R. Motadi, pontsho Moela. RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4308.
Abstract 18087: GLP-1 Receptor Agonist Exenatide Attenuates Endothelial Dysfunction by Reducing Oxidative Stress in Hyperhomocysteinemia via AMPK/eNOS Pathway
Authors: Chak Kwong Cheng, Chi Wai Lau, Xiaoyu Tian, Yu Huang
Journal: Circulation (2017)

Introduction: Hyperhomocysteinemia (HHcy) is an independent risk factor of various CVD including hypertension and atherosclerosis. HHcy induces excessive oxidative stress to impair endothelial func...
Oral GLP-1 Analog for Type 2 Diabetes on the Horizon
Authors: Jennifer Abbasi
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12735: Differences in the Tolerable Threshold of Right Ventricular Volume Predict Adverse Events in Patients With Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension
Authors: KoyaOzawa, NobusadaFunabashi, HiroyukiTakaoka, NobuhiroTanabe, KoichiroTatsumi, YoshioKobayashi
Journal: Circulation (2014)

Introduction: Right ventricular (RV) volume measurements may predict short term prognosis in patients with pulmonary arterial hypertension (PAH) and chronic pulmonary thromboembolic pulmonary hypertension (PH) (CTEPH) but quantitative thresholds of RV volume that predict occurrence of adverse events (AE) may differ between both groups. Hypothesis: To evaluate tolerance of RV volume in PAH and CTEPH patients by comparing quantitative thresholds of RV end diastolic (RVEDV) and end systolic volume (RVESV) by CT as predictors of AE. Method: 43 confirmed PH patients (14 PAH (4 males, 49 ± 16 yrs) and 29 CTEPH patients (9 males, 58 ± 15 yrs) underwent retrospective ECG gated 320 slice CT (Aquilion one). CT images were reconstructed every 5% from 0-95% of ECG R-to-R interval and RVEDV and RVESV were measured. Subjects were followed for a median of 31.5 months for PAH and 21 months for CTEPH. AE included cardiac death and hospitalization due to heart failure. Results: AE occurred in 2 PAH and 3 CTEPH patients. Re...
Abstract 83: The role of Nrf2-Keap1 pathway in the survival of circulating metastatic cancer cells
Authors: Hashim M. Aljohani, John M. Furgason, Peter Amaya, Ayham Deeb, Jeffery J. Chalmers, El Mustapha Bahassi
Journal: Cancer Research (2018)

Abstract Approximately 90% of all cancer deaths arise from the metastatic spread of primary tumors. Of all the processes involved in carcinogenesis, local invasion and the formation of metastases are clinically the most relevant, but they are the least well understood at the molecular level. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” in circulation. The recent technological advances in the isolation and characterization of rare circulating tumor cells (CTCs) will allow a better understanding of anoikis resistance. Detailed molecular and functional analyses of anoikis-resistant cells may provide insight into the biology of cancer metastasis and help identify novel targets for prevention of cancer dissemination. To uncover the molecular changes that govern the transition from a primary lung tumor to a secondary metastasis and specifically the mechanisms by which CTCs survive in circulation, we carried out whole-genome sequencing (WGS) of normal lung, primary tumors and the corresponding brain metastases from five patients with progressive metastatic NSCLC. We also isolated CTCs from patients with metastatic cancer and subjected them to whole-genome amplification and Sanger sequencing and quantitative digital PCR of genes of interest. While the primary tumors showed mutations in genes associated with cell adhesion and motility, brain metastases acquired mutations in adaptive and cytoprotective genes involved in the response to cellular stress such as Keap1, Nrf2 and E300, which are key players of the Keap1-Nrf2-ARE survival pathway. Nrf2 is a transcriptional factor that upon stress translocates into the nucleus, binds to the ARE (anti-oxidant response elements) and drives the expression of antioxidant genes. The identified mutations affect regulatory domains in all three proteins, suggesting a functional role in providing a survival advantage to CTCs in the peripheral blood, allowing their dissemination to distant organs. Citation Format: Hashim M. Aljohani, John M. Furgason, Peter Amaya, Ayham Deeb, Jeffery J. Chalmers, El Mustapha Bahassi. The role of Nrf2-Keap1 pathway in the survival of circulating metastatic cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 83.
Radical Outcome Method
Authors: KevinTurley, MichaelTyndall, KerryTurley, DeweyWoo, ThomasMohr
Journal: Circulation (1995)

Background Treatment of congenital heart disease has entered a new era of healthcare delivery and cost containment. Critical pathway method (CPM) has been previously demonstrated by us to produce a significant reduction in average length of stay (ALOS) in hospital of −44%. A new approach, radical outcome method (ROM), has produced comparable results that appear to improve over time. The dynamic nature is examined. Methods and Results Two hundred consecutive patients with congenital heart disease were treated by a single surgeon at a single health maintenance organization (HMO) facility. ROM was used in all patients. This method uses seven critical moments at which shortening rather than confirmation of the ALOS is possible. This process is completed by the second post-operative day. Overall mortality was 1%. The 200 patients were divided into two consecutive groups of 100 patients to determine the effectiveness of ROM over time. Fifty sets were matched. ALOS hospital decreased by 29 days (mean, 0.6 d/set)...
<i>Notes from the Field:</i> Toxigenic <i>Vibrio cholerae</i> O141 in a Traveler to Florida — Nebraska, 2017
Authors: Brianna K.D. Loeck, Amy Roberts, Arryn R. Craney, Stephanie King, Monica S. Im, Thomas J. Safranek, Peter C. Iwen, Anna V. Carlson, Caitlin Pedati
Journal: MMWR Morbidity and Mortality Weekly Report (2018)
Blockade of Endogenous Cytokines Mitigates Neointimal Formation in Obese Zucker Rats
Authors: RyoTakeda, EtsuSuzuki, HiroshiSatonaka, ShigeyoshiOba, HiroakiNishimatsu, MasaoOmata, ToshiroFujita, RyozoNagai, YasunobuHirata
Journal: Circulation (2005)

Background— It is well known that diabetes mellitus is a major risk factor for vascular diseases such as atherosclerosis and restenosis after angioplasty. It has become clear that advanced glycation end products (AGE) and their receptor (RAGE) are implicated in vascular diseases, especially in diabetes mellitus. Nevertheless, the mechanisms by which diabetes mellitus is often associated with vascular diseases remain unclear. Methods and Results— To study the role of endogenous cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 in the development of vascular diseases and in the expression of RAGE, we used semapimod, a pharmacological inhibitor of cytokine production, and examined its effect on neointimal formation in the femoral artery of obese Zucker (OZ) rats. We also used an adenovirus construct expressing a dominant negative mutant of the receptor for TNF-α (AdTNFRΔC) to block the action of endogenous TNF-α. Semapimod significantly suppressed neointimal formation and RAGE expression in...
Abstract 17191: Fragmentation Assessed by Magnetocardiography but not Electrocardiogram Can Predict Future Cardiac Events in Patients with Non-ischemic Dilated Cardiomyopathy and Narrow QRS
Authors: ShojiKawakami, HiroshiTakaki, ShujiHashimoto, MitsuruWada, KoheiIshibashi, IkutaroNakajima, KojiMiyamoto, HideoOkamura, TakashiNoda, TakeshiAiba, KengoKusano, SatoshiYasuda, HisaoOgawa, ShiroKamakura, MasaruSugimachi
Journal: Circulation (2014)

Background: Fragmented QRS (fQRS) in 12-lead ECG, ascribed to myocardial scar, has been shown to predict future cardiac events in patients with both ischemic and non-ischemic dilated cardiomyopathy (NIDCM). Various definitions and low specificity of fQRS, however, limited its use. We hypothesized that the advantage of 64-channel magnetocardiography (MCG), i.e., high spatio-temporal resolution, enables more accurate detection of fragmented LV conduction (fLV), that would lead to accurate prediction of future events. Methods: In 51 patients with NIDCM and narrow QRS (LVEF, 22±7%; QRS duration, 99±11 ms), we recorded MCG. We defined, in MCG superimposed vector magnitude waveforms, fLV as distinct abnormal components (>20% of maximal amplitude). In current arrow map, fLV corresponded to heterogeneous QRS currents (Figure). We predicted major adverse cardiac events (MACE), including sudden cardiac death (SCD), sustained ventricular tachyarrhythmias (VF/VT), appropriate defibrillator discharge (Def) and left ve...