tbuckley/cabot-search huggingface dataset:
Abstract 13132: Evolving Heart Block treated With a CHOP
Authors: Rami K Zein, Jason A Mouabbi, Mohammed Inany, Tarik Hadid, Thomas Lalonde
Journal: Circulation (2016)

Introduction: Primary cardiac lymphoma (PCL) is a very rare disorder accounting for less than 1% of all lymphomas. Presenting symptoms may be chest pain, congestive heart failure, pericardial effusions and arrhythmias. Herein, we present the case of a 62- year-old immunocompetent female with a one week history of worsening endurance and Wenckebach heart block who was ultimately diagnosed with primary cardiac lymphoma. Case: A 62-year-old woman was admitted with dyspnea, fatigue and bilateral pitting edema for 1 week. She was bradycardic with a heart rate of 55. Clinical examination was otherwise unremarkable. Electrocardiogram demonstrated Mobitz I second degree AV block. Echocardiography subsequently revealed a right atrial and ventricular mass. CT angiography of the chest demonstrated a 4-5 centimeter filling defect surfacing from the posterior right atrial and ventricular wall. She subsequently developed complete AV block with runs of ventricular tachycardia during her hospitalization requiring biventricular pacemaker implantation with automatic defibrillator. Excisional biopsy revealed diffuse large B-cell lymphoma. Patient underwent 6 cycles of rituximab, cyclophosphamide, adriamycin, vincristine and prednisone (R-CHOP) and achieved complete remission. Discussion: PCL often presents with non-specific symptoms that vary depending on the locations in the myocardium. The most common clinical manifestations are pericardial effusion, AV block and heart failure being the most common cause of death. Imaging studies are essential in estimating the extent of disease. However, surgical intervention is needed to confirm the diagnosis histologically. Fortunately, early treatment with R-CHOP can lead to remission. This case represents a fascinating presentation of a very rare malignancy.
P1.02-065 Histone Deacetylase Inhibition Alters Stem Cell Phenotype in Gefitinib-Resistant Lung Cancer Cells with EGFR Mutation
Authors: F. Nurwidya, F. Takahashi, M. Hidayat, I. Kobayashi, A. Wirawan, M. Kato, K. Tajima, N. Shimada, I. Takeda, M. Tajima, N. Matsumoto, K. Kanemori, Y. Koinuma, F. Yunus, S. Andarini, K. Takahashi
Journal: Journal of Thoracic Oncology (2017)
Genetic Variants in<i><scp>ERAP</scp>1</i>and<i><scp>ERAP</scp>2</i>Associated With Immune‐Mediated Diseases Influence Protein Expression and the Isoform Profile
Authors: Aimee L. Hanson, Thomas Cuddihy, Katelin Haynes, Dorothy Loo, Craig J. Morton, Udo Oppermann, Paul Leo, Gethin P. Thomas, Kim‐Anh Lê Cao, Tony J. Kenna, Matthew A. Brown
Journal: Arthritis & Rheumatology (2017)

Objective Endoplasmic reticulum aminopeptidase 1 ( ERAP ‐1) and ERAP ‐2 , encoded on chromosome 5q15, trim endogenous peptides for HLA ‐mediated presentation to the immune system. Polymorphisms in ERAP 1 and/or ERAP 2 are strongly associated with several immune‐mediated diseases with specific HLA backgrounds, implicating altered peptide handling and presentation as prerequisites for autoreactivity against an arthritogenic peptide. Given the thorough characterization of disease risk–associated polymorphisms that alter ERAP activity, this study aimed instead to interrogate the expression effect of chromosome 5q15 polymorphisms to determine their effect on ERAP isoform and protein expression. Methods RNA sequencing and genotyping across chromosome 5q15 were performed to detect genetic variants in ERAP 1 and ERAP 2 associated with altered total gene and isoform‐specific expression. The functional implication of a putative messenger RNA splice‐altering variant on ERAP ‐1 protein levels was validated using mass spectrometry. Results Polymorphisms associated with ankylosing spondylitis ( AS ) significantly influenced the transcript and protein expression of ERAP‐1 and ERAP‐2. Disease risk–associated polymorphisms in and around both genes were also associated with increased gene expression. Furthermore, key risk‐associated ERAP 1 variants were associated with altered transcript splicing, leading to allele‐dependent alternate expression of 2 distinct isoforms and significant differences in the type of ERAP ‐1 protein produced. Conclusion In accordance with studies demonstrating that polymorphisms that increase aminopeptidase activity predispose to immune disease, the increased risk also attributed to increased expression of ERAP 1 and ERAP 2 supports the notion of using aminopeptidase inhibition to treat AS and other ERAP ‐associated conditions.
Abstract 21301: Effect of Chest Compression Parameter Variation on Waveform Characteristics of the Ventricular Fibrillation Electrocardiogram
Authors: David D Salcido, Matthew L Sundermann, Allison C Koller, Rena Sufrin, John Kucewicz, Graham Nichol, Adeyinka Adedipe, James J Menegazzi
Journal: Circulation (2017)

Introduction: The ventricular fibrillation (VF) electrocardiogram (ECG) waveform is known to deteriorate over time if untreated, recover with CPR, and to predict defibrillation success. VF ECG measures could inform CPR quality feedback algorithms based on patient physiologic response. Objectives: Investigate the effects of chest compression parameters (rate, depth and duty cycle (DC)) on VF ECG waveform characteristics in a swine cardiac arrest model. Methods: Twelve mixed-breed domestic swine were sedated, anesthetized and paralyzed, followed by endotracheal intubation and mechanical ventilation. Animals were instrumented with a battery of physiological sensors, including multi-lead ECG, recorded continuously with a high-fidelity data acquisition unit at 1000Hz. VF was induced with a 3-second 100mA transthoracic shock. After 7 minutes, animals were randomized to receive continuous CPR with a custom robotic device using 1 of 6 pre-programmed, cross-over 2-phase CPR schemes that varied 1 parameter in 5 x 1-minute intervals per phase while holding the other 2 parameters fixed. Frequency (AMSA) and slope-based (MS) quantitative ECG characteristics of the ECG were calculated at the end of each 1-minute interval and compared between rate, depth and DC schemes, as well as experimental phases. Correlations between CPR parameter settings and ECG characteristics were calculated. Results: Compression rate showed a low-to-moderate correlation (0.454) with change in MS in Phase I, however neither DC nor depth showed a correlation with either AMSA or MS. In ANOVA models, MS differed between CPR groups at the end of Phase I (p = 0.046) but not AMSA, suggesting similar response of quantitative ECG measures after extended time intervals. Conclusions: In this study only chest compression rate in early phase CPR appeared to be related to quantitative characteristics of the VF ECG. Rate may be important clinically in the early phase of CPR.
P2.14-004 Comparable Local Controls after Twice-Daily and Once-Daily Chest Radiotherapy in Extensive Stage Small Cell Lung Cancer
Authors: Q. Li, B. Qiu, W. Xie, Z. Hui, B. Wang, Y. Liang, J. Guo, Y. Zhou, M. Zhu, W. Shen, R. Duan, L. Chen, L. Zhang, H. Long, H. Liu
Journal: Journal of Thoracic Oncology (2017)
A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma
Authors: Dan R Laks, Juan A Oses-Prieto, Alvaro G Alvarado, Jonathan Nakashima, Shreya Chand, Daniel B Azzam, Ankur A Gholkar, Jantzen Sperry, Kirsten Ludwig, Michael C Condro, Serli Nazarian, Anjelica Cardenas, Michelle Y S Shih, Robert Damoiseaux, Bryan France, Nicholas Orozco, Koppany Visnyei, Thomas J Crisman, Fuying Gao, Jorge Z Torres, Giovanni Coppola, Alma L Burlingame, Harley I Kornblum
Journal: Neuro-Oncology (2017)

Clinical trials of therapies directed against nodes of the signaling axis of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin (mTOR) in glioblastoma (GBM) have had disappointing results. Resistance to mTOR inhibitors limits their efficacy.To determine mechanisms of resistance to chronic mTOR inhibition, we performed tandem screens on patient-derived GBM cultures.An unbiased phosphoproteomic screen quantified phosphorylation changes associated with chronic exposure to the mTOR inhibitor rapamycin, and our analysis implicated a role for glycogen synthase kinase (GSK)3B attenuation in mediating resistance that was confirmed by functional studies. A targeted short hairpin RNA screen and further functional studies both in vitro and in vivo demonstrated that microtubule-associated protein (MAP)1B, previously associated predominantly with neurons, is a downstream effector of GSK3B-mediated resistance. Furthermore, we provide evidence that chronic rapamycin induces microtubule stability in a MAP1B-dependent manner in GBM cells. Additional experiments explicate a signaling pathway wherein combinatorial extracellular signal-regulated kinase (ERK)/mTOR targeting abrogates inhibitory phosphorylation of GSK3B, leads to phosphorylation of MAP1B, and confers sensitization.These data portray a compensatory molecular signaling network that imparts resistance to chronic mTOR inhibition in primary, human GBM cell cultures and points toward new therapeutic strategies.
MA 05.12 Oncogenic Drivers Induce Production of CCL5 to Recruit Regulatory T-Cells Early in Lung Cancer Progression
Authors: E. Franks, E. Halvorsen, E. Melesse, A. Unni, J. Collier, M.H. Oh, V. Lam, G. Krystal, J.C. English, W. Lam, S. Lam, N. Abraham, K. Bennewith, W. Lockwood
Journal: Journal of Thoracic Oncology (2017)
NIMG-02. MULTI-CENTER STUDY DEMONSTRATES RADIOMIC TEXTURE FEATURES DERIVED FROM MR PERFUSION IMAGES PREDICT PSEUDOPROGRESSION FROM TRUE PROGRESSION IN GLIOBLASTOMA PATIENTS
Authors: Nabil Elshafeey, Aikaterini Kotrotsou, Srishti Abrol, Islam Hassan, Ahmed Hassan, Anand Agarwal, Kamel Salek, Samuel Bergamaschi, Fanny Moron, Meng Law, Pascal Zinn, Rivka Colen
Journal: Neuro-Oncology (2017)

To differentiate between pseudoprogression and true progression in patients with glioblastoma using MR perfusion radiomic texture analysis (TA). 98 patients with pathologically-proven diagnosis of GBM were retrospectively included in this IRB approved HIPAA compliant study. All patients underwent DSC and DCE Perfusion MRI as part of their routine clinical care. Images were analyzed using Nordic ICE 2.3 (NordicNeuroLab) ; rCBV and ktrans maps were obtained. Subsequently, 3D slicer 4.3.1(http://www.slicer.org) was used to segment the entire tumor on the different processed maps to create a volume of interest (VOI) for Radiomic TA. Multiple invariant texture features where then extracted from each VOI. 475 invariant texture features were applied to each map. Leave-one-out cross-validation (LOOCV), receiver operating characteristic (ROC), Kaplan Meier, and multivariate Cox proportional hazards regression analyses were used to assess the relationship between texture feature and pseudoprogression and true progression. Variance and sum entropy were the two most significant radiomic features that discriminated between pseudoprogression and true progression. P value, AUC, specificity and sensitivity were 0.03, 89.26%, 81.82%, and 100% respectively. Radiomic TA derived from perfusion images can be helpful in determining true versus pseudoprogression in GBM. Further, this study illustrates successful application of radiomic TA as an advanced processing step for different MRI perfusion maps (DCE, DSC).
Small bowel adenocarcinoma (SBA) is a rare and heterogeneous disease: results of a retrospective analysis
Authors: K. Andrikou, A. Bittoni, R. Giampieri, G. Pugliese, G. Orsi, M. Barbolini, A. Lanese, R. Berardi, S. Cascinu
Journal: Annals of Oncology (2017)
Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing
Authors: Nathaniel P. Hoyle, Estere Seinkmane, Marrit Putker, Kevin A. Feeney, Toke P. Krogager, Johanna E. Chesham, Liam K. Bray, Justyn M. Thomas, Ken Dunn, John Blaikley, John S. O’Neill
Journal: Science Translational Medicine (2017)

The circadian clock in fibroblasts determines the efficiency of wound healing through rhythmic regulation of actin cytoskeletal dynamics.
Social stress induces neurovascular pathology promoting depression
Authors: Caroline Menard, Madeline L. Pfau, Georgia E. Hodes, Veronika Kana, Victoria X. Wang, Sylvain Bouchard, Aki Takahashi, Meghan E. Flanigan, Hossein Aleyasin, Katherine B. LeClair, William G. Janssen, Benoit Labonté, Eric M. Parise, Zachary S. Lorsch, Sam A. Golden, Mitra Heshmati, Carol Tamminga, Gustavo Turecki, Matthew Campbell, Zahi A. Fayad, Cheuk Ying Tang, Miriam Merad, Scott J. Russo
Journal: Nature Neuroscience (2017)
Safety and Efficacy of Abiraterone Acetate in Patients (pts) aged 75 or more with Metastatic Castration Resistant Prostate Cancer (mCRPC) in Both Pre-chemotherapy and Post-chemotherapy Settings: The Real Life Experience of Our Institution
Authors: Z. Sirotovà, G. Courthod, O.E. Cursio, A. Battaglia, A. Trogu, S. Spinazzè, A. Stella, M. Schena
Journal: Annals of Oncology (2017)
PDTM-41. TG02, A NOVEL MULTIKINASE INHIBITOR, IS EFFECTIVE IN PEDIATRIC BRAIN TUMORS, WITH SELECTIVE POTENCY IN THOSE WITH MYC EXPRESSION
Authors: Elizabeth Wadhwa, Kristan Meetze, Theo Nicolaides
Journal: Neuro-Oncology (2017)

Brain tumors account for the most cancer-related deaths among children. MYC is one of the key oncogenes implicated in the tumor pathogenesis, and MYC (c-MYC, MYCN, and MYCL) deregulation is common in various types of malignant brain tumors in children, including those with the worst prognoses. Subsets of pediatric glioblastoma (GBM), medulloblastoma, diffuse intrinsic pontine glioma (DIPG), and atypical teratoid rhabdoid tumor (ATRT) have been shown to harbor MYC overexpression, amplification, and chromosomal translocation. Cyclin-dependent kinase 9 (CDK9) is a key regulator of transcription via its substrate, RNA polymerase II, and with CDK9 inhibition, very short-lived proteins are rapidly depleted, resulting in caspase activation and subsequent apoptosis. MYC is a short-lived protein that plays a prominent role in cancer cell survival signaling and has been shown to be depleted with CDK9 inhibition. TG02, a novel, orally-bioavailable CDK9 inhibitor, which also inhibits other CDKs (1, 2, 5, 7), works at clinically-achievable exposures and has demonstrated anti-tumor activity in vitro and in vivo. TG02 significantly reduced MYC in cell lines, primary cells, and mouse models of adult glioblastoma, though has not yet been evaluated with pediatric brain tumors. We tested the efficacy against a panel of pediatric brain tumors, both cell lines and primary cells. While treatment with TG02 universally resulted in decreased cell viability, TG02 was selectively more potent in cells with high levels of c-myc expression as compared to those with low levels of expression, with mean IC50 values of 82 nM and 575 nM, respectively. The greatest efficacy in reduction of cell proliferation with TG02 treatment was shown in c-myc-amplified medulloblastoma. Downregulation of c-myc in treated cells was confirmed by immunoblot. This work provides rationale for pursuing in vivo studies testing the efficacy of TG02 in pediatric brain tumors that express MYC.
Vigilancia de las enfermedades transmisibles en los refugiados kosovares en Albania, abril-junio 1999
Authors: M Valenciano, A Pinto, D Coulombier, E Hashorva, M Murthi
Journal: Eurosurveillance (1999)

Albania, un pais con 3,5 millones de habitantes, se enfrenta a una grave crisis socioeconomica. La renta media per capita es inferior a 1.000 US$ por ano y, desde 1995, el desempleo ha aumentado un 2,7% (1). La pobreza y la migracion constituyen los dos problemas sociales mas importantes. El pais esta dividido en 37 distritos administrativos. La atencion sanitaria primaria se suministra a traves de una red de 1500 puestos sanitarios (dotados de enfermeras o comadronas) y 602 centros sanitarios (dotados de medicos de cabecera). La atencion sanitaria secundaria esta a cargo de 53 policlinicas ubicadas en las ciudades, 34 hospitales de distrito y 10 hospitales regionales. La atencion terciaria se ofrece unicamente en el Hospital Universitario de Tirana (2). El sistema de vigilancia nacional permanente monitoriza 73 enfermedades: tanto los centros de salud como los puestos sanitarios transmiten las notificaciones de casos a los epidemiologos de los distritos, quienes a su vez envian informacion mensual al Instituto de Salud Publica (IPH) de Tirana. La calidad de la vigilancia se ve limitada por el grado de fiabilidad de los datos, la subnotificacion, la calidad de los datos, su transmision y el retorno de informacion (3).
GENE-53. SEX-SPECIFIC GENE AND PATHWAY MODELING OF INHERITED GLIOMA RISK
Authors: Quinn Ostrom, Joshua Rubin, Justin Lathia, Michael Berens, Gil Speyer, Warren Coleman, William Huang, Peter Liao, Christopher Amos, Georgina Armstrong, Jonine Bernstein, Elizabeth Claus, Jeanette Eckel-Passow, Helen Hansen, Richard Houlston, Dora Il’yasova, Robert Jenkins, Christoffer Johansen, Daniel Lachance, Rose Lai, Ching Lau, Lucie McCoy, Ryan Merrell, Sara Olson, Terri Rice, Siegal Sadetzki, Joellen Schildkraut, Sanjay Shete, John Wiencke, Beatrice Melin, Margaret Wrensch, Melissa Bondy, Jill Barnholtz-Sloan
Journal: Neuro-Oncology (2017)
The utility of monitoring trimellitic anhydride (<scp>TMA</scp>)‐specific IgG to predict IgE‐mediated sensitization in an immunosurveillance program
Authors: D. Ghosh, C. Clay, J. A. Bernstein
Journal: Allergy (2017)

Abstract Background Workplace exposure to trimellitic anhydride ( TMA ) can elicit TMA ‐specific IgE ( sIgE ), which may lead to occupational asthma ( OA ). An occupational immunosurveillance program ( OISP ) has been implemented to monitor TMA exposure and immunologic outcomes. The purpose of this study was to determine whether TMA ‐specific IgG ( sIgG ) responses can discriminate between TMA ‐exposed workers with and without sIgE responses. Methods Serum TMA ‐specific antibody (IgG, IgG4, and IgE) levels were estimated longitudinally (years 2006 to 2014) in TMA ‐exposed workers recruited in low, medium, and high exposure areas. sIgG and sIgE titers plotted against exposure duration were compared between workers with (a) sIgG only and (b) with sIgG who developed sIgE . Results Among 92 TMA ‐exposed workers continuously monitored for sIgG and sIgE , 38 developed sIgG ; 11 developed a sIgE response 342.38 ± 186.03 days posthire and were removed from exposure. The average detection time of sIgG in removed workers (159 ± 92 days) was significantly shorter than for actively exposed workers with only sIgG (346 ± 187 days). Workers with earlier sIgG responses of higher titer (mean value 42.25 μg/mL) compared to delayed responders with lower sIgG titers (mean value 14.79 μg/mL) more frequently developed sIgE responses. Hierarchical clustering showed the initial magnitude and exposure time required for detectable sIgG production discriminated between workers with only sIgG from workers who subsequently produced sIgE . Conclusions This study demonstrates the utility of longitudinally monitoring TMA ‐specific antibodies in an OISP as exposed workers with early sIgG responses and of higher magnitude are more likely to develop TMA sIgE sensitization.
Maternal Use of Antiepileptic Agents During Pregnancy and Major Congenital Malformations in Children
Authors: Rebecca L. Bromley, Jennifer Weston, Anthony G. Marson
Journal: JAMA (2017)

Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children?Certain antiepileptic drugs were associated with increased rates of congenital malformations (eg, spina bifida, cardiac anomalies). Lamotrigine (2.31% in 4195 pregnancies) and levetiracetam (1.77% in 817 pregnancies) were associated with the lowest risk and valproate was associated with the highest risk (10.93% in 2565 pregnancies) compared with the offspring of women without epilepsy (2.51% in 2154 pregnancies).
Brote de infecciones por Escherichia coli O157 productor de shigatoxina (STEC). Países Bajos, septiembre-octubre de 2005
Authors: Y Doorduyn, C M de Jager, W K van der Zwaluw, I H Friesema, A E Heuvelink, E de Boer, W J B Wannet, Y T H P van Duynhoven
Journal: Eurosurveillance (2006)

En septiembre de 2005, se investigo en los Paises Bajos el primer brote de Escherichia coli O157 productor de shigatoxina (Stx) (STEC) asociado a alimentos. Entre el 11 de septiembre y el 10 de octubre de 2005, se identificaron 21 casos confirmados microbiologicamente (de los cuales uno era caso secundario) y 11 casos probables (dos casos primarios y nueve casos secundarios). Segun las encuestas preliminares, los factores de riesgo posibles eran el consumo de carne de vaca cruda (steak tartaro, tambien llamado « filete americano » en los Paises Bajos), y el contacto con otras personas sintomaticas. El estudio caso-control subsiguiente apoyaba la hipotesis del steak tartaro como fuente del brote (odds-ratio apareado (OR) 272, intervalo de confianza al 95% (IC) 3-23.211). Tambien se asocio el consumo de vegetales listos para consumir con las infecciones por STEC O157 (OR apareado 24, IC 95% 1,1–528), pero fue considerado menos probable, pues solo el 40% de los casos habian sido expuestos. Las muestras de steak tartaro recogidas en una cadena de supermercados donde la mayoria de los pacientes (67%) probablemente lo habian adquirido, dieron todas negativo para STEC O157. Sin embargo, las muestras se tomaron tres dias despues del inicio de sintomas en los ultimos casos declarados. Como la enfermedad ocurrio en un periodo de dos semanas para el 88% de los casos, una contaminacion puntual de la fuente puede ser la explicacion de estos resultados negativos. Se concluyo que el steak tartaro era la causa mas probable de este primer brote por STEC O157 asociado a alimentos en los Paises Bajos.
Genetic Factors Associated with Platinum Toxicity: A Preliminary Study
Authors: B. De Troia, D. Davide, V. Filipazzi, L. Isabella, N. Tosca, S. Ferrario, A. Gambaro, L. Somma, C. Fasola, I. Pellegrini, G. Bombonati, E. Damiani, S. Cheli, F.S. Falvella, E. Clementi, D. de Francesco, M.T. Cattaneo
Journal: Annals of Oncology (2017)
First-line platinum-based chemotherapy in elderly patients with NSCLC: determinants of therapeutic choice and outcome
Authors: G. Pelizzari, L. Gerratana, M. Cattaneo, F. Cortiula, C. Lisanti, M. Bartoletti, M. Giavarra, V. Buoro, E. De Carlo, M. Macerelli, E. Poletto, C. Rossetto, S. Rizzato, F. Puglisi, G. Fasola
Journal: Annals of Oncology (2017)