tbuckley/cabot-search huggingface dataset:
Patterns of autoimmunity and subsequent solid tumors among 4.5 million U.S. veterans
Authors: A. M. Landgren, M. S. Linet, G. Gridley, G. M. Dores, O. Landgren, L. M. Morton
Journal: Journal of Clinical Oncology (2008)

11020 Background: Autoimmune diseases (AIs) are well-known to increase the risk of hematologic malignancies; however, risks for solid tumors are largely unknown. The aim of this large study was to assess the association between a wide range of AIs and subsequent solid tumors. Methods: We identified 4,501,578 male veterans with up to 26 years of follow-up. Based on hospital discharge-record data, we fit Poisson regression models to calculate relative risks (RR) of solid cancer following a history of AIs. Results: A total of 346,258 veterans were diagnosed with a solid tumor. We found a marginally decreased risk (RR=0.98) for any solid tumor following a history of any AI. In contrast, lung cancer risk was increased (RR=1.17 to 1.52) among individuals with a history of systemic AIs (rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis). Simultaneously, lung cancer risk was decreased (RR=0.46 to 0.86) for 9 other AIs (including amyotrophic lateral sclerosis, chronic rheumatic heart disease, multiple sclerosis, ankylosing spondylitis, and ulcerative colitis). Risks for stomach-, small intestinal-, colon-, and rectum/anus cancers were increased (RR=1.66 to 8.24) among individuals with AIs affecting the same location of the gastrointestinal system (pernicious anemia, Crohn disease, and ulcerative colitis). Based on small numbers, Hashimoto thyroiditis was associated with a 28-fold elevated risk of thyroid cancer. Liver cancer risk was increased (RR=2.40 to 6.83) among persons with a history of immune thrombocytopenic purpura, primary biliary cirrhosis, and ulcerative colitis. We found both increased and decreased risk of melanoma skin-, buccal-, bladder- and prostate cancer following various AIs. Conclusions: In this comprehensive investigation based on 4.5 million U.S. veterans, we observed both increased and decreased risk for different solid tumors following individual AIs. Our finding that multiple localized AIs were associated with elevated risk of cancer in the same organ supports the hypothesis that local inflammation might play an important role in tumor development. A better description of underlying mechanisms could ultimately enhance our understanding of carcinogenesis and allow identification of novel molecular targets. No significant financial relationships to disclose.
A Comprehensive Collaborative Nationwide Lymphoma Study in Lebanon: Incidence of Various Subtypes and Analysis of Associations with Viral Infections
Authors: Jad Saab, Zaher Otrock, Georges Aftimos, Fadi Nasr, Fadi Farhat, Saad Khairallah, Gérard Abadjian, Marwan Ghosn, Hassan Sidani, Ahmad Ibrahim, Ayman Tawil, Claude Ghorra, Zarouhie Meguerian, Walid Mokaddem, Walid Dayeh, Ziad Salem, Georges Y. Chahine, Nizar Bitar, Anas Mugharbel, Joseph I. Makdessi, Christina Khater, Mirna El Hajj, Dany Abi Gerges, Charles Sfeir, Joseph Kattan, Khaled Ibrahim, Michel Saade, Hussein Sadek, Rami Mahfouz, Mohamed A. Kharfan-Dabaja, Ghazi Zaatari, Ali Bazarbachi
Journal: Blood (2011)
Detection, Phenotype and Prognostic Significance of the Leukemic Stem Cell Side PopulationHo342low in Acute Myeloid Leukemia.
Authors: Juana Serrano-Lopez, Josefina Serrano, Joaquín Sanchez-Garcia, Noemi Fernandez-Escalada, Maria del Carmen Martinez-Losada, Javier Casaño, Salvador Tabares, Antonio P. Torres Gomez
Journal: Blood (2012)
In-Vitro Treatment of Lymphoma Cell Lines with BAY 43-9006 (Sorafenib) Is Followed by Typical Features of Apoptosis and Down-Regulation of MCL-1 Pointing to an Efficacy of Sorafenib in the Teatment of Lymphoma.
Authors: Dirk Winkler, Christof Schneider, Annett Habermann, Hartmut Doehner, Stephan Stilgenbauer
Journal: Blood (2007)
Tri‐Layered Nanocomposite Hydrogel Scaffold for the Concurrent Regeneration of Cementum, Periodontal Ligament, and Alveolar Bone
Authors: S. Sowmya, Ullas Mony, P. Jayachandran, S. Reshma, R. Arun Kumar, H. Arzate, Shantikumar V. Nair, R. Jayakumar
Journal: Advanced Healthcare Materials (2017)

A tri‐layered scaffolding approach is adopted for the complete and concurrent regeneration of hard tissues—cementum and alveolar bone—and soft tissue—the periodontal ligament (PDL)—at a periodontal defect site. The porous tri‐layered nanocomposite hydrogel scaffold is composed of chitin‐poly(lactic‐ co ‐glycolic acid) (PLGA)/nanobioactive glass ceramic (nBGC)/cementum protein 1 as the cementum layer, chitin–PLGA/fibroblast growth factor 2 as the PDL layer, and chitin–PLGA/nBGC/platelet‐rich plasma derived growth factors as the alveolar bone layer. The tri‐layered nanocomposite hydrogel scaffold is cytocompatible and favored cementogenic, fibrogenic, and osteogenic differentiation of human dental follicle stem cells. In vivo, tri‐layered nanocomposite hydrogel scaffold with/without growth factors is implanted into rabbit maxillary periodontal defects and compared with the controls at 1 and 3 months postoperatively. The tri‐layered nanocomposite hydrogel scaffold with growth factors demonstrates complete defect closure and healing with new cancellous‐like tissue formation on microcomputed tomography analysis. Histological and immunohistochemical analyses further confirm the formation of new cementum, fibrous PDL, and alveolar bone with well‐defined bony trabeculae in comparison to the other three groups. In conclusion, the tri‐layered nanocomposite hydrogel scaffold with growth factors can serve as an alternative regenerative approach to achieve simultaneous and complete periodontal regeneration.
Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
Authors: Peiran Yang, Cai Read, Rhoda E. Kuc, Guido Buonincontri, Mark Southwood, Rubben Torella, Paul D. Upton, Alexi Crosby, Stephen J. Sawiak, T. Adrian Carpenter, Robert C. Glen, Nicholas W. Morrell, Janet J. Maguire, Anthony P. Davenport
Journal: Circulation (2017)

Elabela/toddler (ELA) is a critical cardiac developmental peptide that acts through the G-protein-coupled apelin receptor, despite lack of sequence similarity to the established ligand apelin. Our aim was to investigate the receptor pharmacology, expression pattern, and in vivo function of ELA peptides in the adult cardiovascular system, to seek evidence for alteration in pulmonary arterial hypertension (PAH) in which apelin signaling is downregulated, and to demonstrate attenuation of PAH severity with exogenous administration of ELA in a rat model.In silico docking analysis, competition binding experiments, and downstream assays were used to characterize ELA receptor binding in human heart and signaling in cells expressing the apelin receptor. ELA expression in human cardiovascular tissues and plasma was determined using real-time quantitative polymerase chain reaction, dual-labeling immunofluorescent staining, and immunoassays. Acute cardiac effects of ELA-32 and [Pyr1]apelin-13 were assessed by MRI and cardiac catheterization in anesthetized rats. Cardiopulmonary human and rat tissues from PAH patients and monocrotaline- and Sugen/hypoxia-exposed rats were used to show changes in ELA expression in PAH. The effect of ELA treatment on cardiopulmonary remodeling in PAH was investigated in the monocrotaline rat model.ELA competed for binding of apelin in human heart with overlap for the 2 peptides indicated by in silico modeling. ELA activated G-protein- and β-arrestin-dependent pathways. We detected ELA expression in human vascular endothelium and plasma. Comparable to apelin, ELA increased cardiac contractility, ejection fraction, and cardiac output and elicited vasodilatation in rat in vivo. ELA expression was reduced in cardiopulmonary tissues from PAH patients and PAH rat models, respectively. ELA treatment significantly attenuated elevation of right ventricular systolic pressure and right ventricular hypertrophy and pulmonary vascular remodeling in monocrotaline-exposed rats.These results show that ELA is an endogenous agonist of the human apelin receptor, exhibits a cardiovascular profile comparable to apelin, and is downregulated in human disease and rodent PAH models, and exogenous peptide can reduce the severity of cardiopulmonary remodeling and function in PAH in rats. This study provides additional proof of principle that an apelin receptor agonist may be of therapeutic use in PAH in humans.
Eating overcooked starchy food is linked to cancer, agency warns
Authors: Anne Gulland
Journal: BMJ (2017)

Consumers are being warned about the dangers of overcooking toast, potatoes, and other starchy food because acrylamide, a chemical that is produced during cooking, has been linked to cancer.

The dangers of high levels of acrylamide have been recognised for about a decade, but in 2015 the European Food Safety Authority published a risk assessment saying that high levels of acrylamide in food potentially increased the risk of developing all types of cancer in all age groups.1

The Food …
Membranous Glomerulonephritis and Nephrotic Syndrome as a Late Manifestation of Chronic Graft-Versus-Host Reaction Following Allogeneic Transplantation for Hematologic Malignancy.
Authors: Bashir Ahmad, Barbara Stehr, Laura Johnston, Eileen Patricia Smith, Auayporn P. Nademanee, Pablo Miguel Parker, Robert Negrin, Stephen J. Forman
Journal: Blood (2006)
Defining Abnormal Fetal Growth and Perinatal Risk: Population or Customized Standards?
Authors: Sarah J. Stock, Jenny Myers
Journal: PLoS Medicine (2017)

Appropriate fetal growth and development in utero is essential for newborn health and lifelong well-being.Both fetal growth restriction (in which the fetus does not achieve its growth potential, usually because of placental insufficiency) and macrosomia (excessive in utero growth, frequently associated with maternal obesity and/or diabetes), are associated with stillbirth, neonatal morbidity and mortality, and long-term risks to health [1,2].An aim of obstetric care is to detect fetuses at risk of complications from fetal growth disorders and intervene to reduce the risk.In reality, the only current effective intervention to prevent stillbirth is delivery of the fetus at a point when the risks of continuing the pregnancy are thought to outweigh the risks of birth [3].It is presumed, although not proven, that timely delivery also minimizes neonatal and longer-term morbidities and mortality.There is substantial variation in the fetal and newborn growth charts used to detect growth deviations.Although there is broad recognition that appropriate unified standards are needed, two different approaches to fetal and neonatal growth assessment have been advocated.One is based on the premise that fetal growth is strongly influenced by genetic factors and adjusts for this by creation of growth charts customized for specific phenotypic traits such as maternal ethnicity, height, and weight [4].The other is to define optimal fetal growth standards at a population level.This is based on the theory that growth potential is similar across populations, and deviation from this norm indicates deprivation or other environmental influences rather than inherent biological differences [5].Although there are enthusiasts for each approach, they have yet to be directly compared in a clinical trial, and it is not clear if either is superior for detecting the fetus or infant at risk of morbidity because of growth disorders.We are thus reliant on evidence from observational studies.Two articles published in PLOS Medicine contribute to the evidence base regarding the use of population charts for detection of fetal growth disorders and how best to determine risk of complications [6,7].Kiserud et al. [6] from the World Health Organization (WHO) performed a prospective cohort study in around 1,400 women in ten middle-and high-income countries with the aim of creating population standard fetal growth charts.The work followed on from the production of WHO international growth standards for infants and children up to age five years, based on the concept that growth potential is similar across all populations.However, although the authors produced fetal growth charts for international use, they did find significant variation in growth between countries, with a difference in median birth weight of approximately 300 g in countries with comparable maternal complication rates; this is significantly greater than the difference between male and female infants.Furthermore, growth was influenced to a
Efficacy and Safety of Deferasirox (Exjade®) in Patients with Transfusion- Dependent Anemias: 1-Year Results from the Large, Prospective, Multicenter EPIC Study
Authors: Maria Domenica Cappellini, Amal El-Beshlawy, Antonis Kattamis, Jong Wook Lee, John F Seymour, Chi-Kong Li, Dany Habr, Gabor Domokos, Abdel Hmissi, Mohsen Saleh Elalfy
Journal: Blood (2008)
Characterization of Leaf Transcriptome in <i>Banksia Hookeriana</i>
Authors: Sim Lin Lim, Haylee M. D’Agui, Neal J. Enright, Tianhua He
Journal: Genomics Proteomics & Bioinformatics (2017)

Abstract Banksia is a significant element in vegetation of southwestern Australia, a biodiversity hotspot with global significance. In particular, Banksia hookeriana represents a species with significant economic and ecological importance in the region. For better conservation and management, we reported an overview of transcriptome of B. hookeriana using RNA-seq and de novo assembly. We have generated a total of 202.7 million reads (18.91 billion of nucleotides) from four leaf samples in four plants of B. hookeriana, and assembled 59,063 unigenes (average size = 1098 bp) through de novotranscriptome assembly. Among them, 39,686 unigenes were annotated against the Swiss-Prot, Clusters of Orthologous Groups (COG), and NCBI non-redundant (NR) protein databases. We showed that there was approximately one single nucleotide polymorphism (SNP) per 5.6–7.1 kb in the transcriptome, and the ratio of transitional to transversional polymorphisms was approximately 1.82. We compared unigenes of B. hookeriana to those of Arabidopsis thaliana and Nelumbo nucifera through sequence homology, Gene Ontology (GO) annotation, and KEGG pathway analyses. The comparative analysis revealed that unigenes of B. hookeriana were closely related to those of N. nucifera. B. hookeriana, N. nucifera, and A. thaliana shared similar GO annotations but different distributions in KEGG pathways, indicating that B. hookeriana has adapted to dry-Mediterranean type shrublands via regulating expression of specific genes. In total 1927 potential simple sequence repeat (SSR) markers were discovered, which could be used in the genotype and genetic diversity studies of the Banksia genus. Our results provide valuable sequence resource for further study in Banksia.
RNA-Binding Protein VICKZ Is Expressed in a Germinal Center Associated Pattern among Lymphoma Subtypes.
Authors: Yasodha Natkunam, Gilad Vainer, Shuchun Zhao, Gail Amir, Eli Pikarsky, Anne S. Hammer, Stephen Hamilton-Dutoit, Ronald Levy, Joel K. Yisraeli, Izidore S. Lossos
Journal: Blood (2005)
Multiple Myeloma Plasma Cell Expression of Hepatocyte Growth Factor mRNA Isoforms Correlates with Overall Survival In Myeloma Patients
Authors: Ida Bruun Kristensen, Jacob Haaber Christensen, Maria Lyng, Tobias W Klausen, Lene Meldgaard Knudsen, Inger Marie S Dahl, Thomas Rasmussen, Henrik Ditzel, Niels Abildgaard
Journal: Blood (2010)
Induction of a CTL-Like Phenotype In B-CLL Cells Stimulated with Interleukin 21 and CpG Oligodeoxynucleotides
Authors: Bernd Jahrsdoerfer, Sue E Blackwell, Magdalena Hagn, Verena Ebel, Thamara Beyer, Kai Sontheimer, Karen Dahlke, George Weiner, Thomas Simmet
Journal: Blood (2010)
MNGO-15TYPE 2 DIABETES MELLITUS IS AN INDEPENDENT RISK FACTOR FOR PERIOPERATIVE COMPLICATIONS IN PATIENTS SURGICALLY TREATED FOR MENINGIOMA
Authors: Arash Nayeri, Philip Brinson, Marc Prablek, Diana Douleh, Lola Chambless
Journal: Neuro-Oncology (2015)

OBJECTIVES: Increased risk of perioperative complications in patients with type 2 diabetes mellitus (DM) has previously been noted with regard to a number of different operations. We sought to study the relative rates of perioperative complications after the surgical resection of a meningioma based on a pre-existing diagnosis of diabetes. METHODS: We conducted a retrospective cohort study on 259 patients who underwent a primary meningioma resection at our institution between 2001-2013. The medical record was reviewed to identify a pre-existing diagnosis of type 2 DM and to obtain patient age, body mass index (BMI), and preoperative Karnofsky Performance Status (KPS) scores. Components of perioperative complications included duration of postoperative hospital stay, intensive care unit (ICU) stay, perioperative changes in KPS scores, and any postoperative emergency department (ED) presentation within 90 days of the operation. Variables associated with perioperative complications in a univariate analysis were included in the multivariate Standard Least Squares model. RESULTS: Average postoperative hospital and ICU stays were respectively 7.6 and 6.0 days amongst diabetics compared to 4.7 and 2.9 days amongst non-diabetics. The mean perioperative KPS score change in diabetics was -2.7 compared to +5.6 in non-diabetics. 48.4% of diabetic patients presented to the ED postoperatively compared to 19.1% of non-diabetics. In the multivariate model, diabetics were found to have significantly longer durations of postoperative hospital and ICU stays, poorer performance status changes, and increased risk of postoperative ED presentation than non-diabetics independent of patient age, pre-operative KPS, and BMI (p = 0.036,p = 0.0006,p = 0.0003, and p = 0.0011 respectively). CONCLUSIONS: Patients with pre-existing diagnoses of type 2 diabetes are at increased risk of lengthier hospital and ICU stays during their operative hospital admission and postoperatively present to the ED at a higher rate than non-diabetics. Further studies are needed to elucidate the optimal perioperative management of diabetic patients surgically treated for meningioma.
Unrelated Cord Blood Transplantation after Nonmyeloablative Conditioning: Single Institutional Retrospective Comparison with Bone Marrow or Peripheral Blood Stem-Cell Transplants.
Authors: Koichiro Kobayashi, Yoshinobu Maeda, Hisakazu Nishimori, Haruko Sugiyama, Kazutoshi Aoyama, Tomoko Kikuchi, Noriko Namba, Shiro Kubonishi, Masami Niiya, Katsuji Shinagawa, Kazuma Ikeda, Mitsune Tanimoto
Journal: Blood (2008)
<i>Notes from the Field</i>: Knowledge, Attitudes, and Practices Regarding Yellow Fever Vaccination Among Men During an Outbreak — Luanda, Angola, 2016
Authors: Mariel A. Marlow, Maria Augusta Chitula de Feliciano Pambasange, Constantino Francisco, Odete Da Conceiçao Bambi Receado, Maria Jose Soares, Sandra Silva, Carlos Navarro-Colorado, Emily Zielinski-Gutierrez
Journal: MMWR Morbidity and Mortality Weekly Report (2017)
Microrna-34a As a Marker for Fludarabine Resistance and Impairment of p53-Pathway in Chronic Lymphocytic Leukemia
Authors: Marek Mraz, Katerina Cerna, Veronika Mayerova, Katerina Musilova, Karla Plevova, Sarka Pavlova, Boris Tichy, Michael Doubek, Yvona Brychtova, Jitka Malcikova, Jiri Mayer, Martin Trbusek, Sarka Pospisilova
Journal: Blood (2012)
Myelodysplastic Syndromes, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology
Authors: Peter L. Greenberg, Richard M. Stone, Aref Al-Kali, Stefan K. Barta, Rafael Bejar, John M. Bennett, Hetty Carraway, Carlos M. De Castro, H. Joachim Deeg, Amy E. DeZern, Amir T. Fathi, Olga Frankfurt, Karin Gaensler, Guillermo Garcia-Manero, Elizabeth A. Griffiths, David Head, Ruth Horsfall, Robert A. Johnson, Mark Juckett, Virginia M. Klimek, Rami Komrokji, Lisa A. Kujawski, Lori J. Maness, Margaret R. O'Donnell, Daniel A. Pollyea, Paul J. Shami, Brady L. Stein, Alison R. Walker, Peter Westervelt, Amer Zeidan, Dorothy A. Shead, Courtney Smith
Journal: Journal of the National Comprehensive Cancer Network (2016)

The myelodysplastic syndromes (MDS) comprise a heterogenous group of myeloid disorders with a highly variable disease course. Diagnostic criteria to better stratify patients with MDS continue to evolve, based on morphology, cytogenetics, and the presence of cytopenias. More accurate classification of patients will allow for better treatment guidance. Treatment encompasses supportive care, treatment of anemia, low-intensity therapy, and high-intensity therapy. This portion of the guidelines focuses on diagnostic classification, molecular abnormalities, therapeutic options, and recommended treatment approaches.
Optimized response prediction in esophagogastric junction adenocarcinomas (EGJAc) with combination of molecular biomarkers and FDG-PET.
Authors: Russell David Petty, Gillian H Bain, Graeme I Murray, Fiona Jane Gilbert, Alan Denison, Fergus Mckiddie, Trevor Ahearns, John Leeds, Perminder Phull, Ken Park, Shayanthan Nanthakumaran, Andy Welch, Lutz Schweiger, Eliana Collie-Duguid
Journal: Journal of Clinical Oncology (2012)

1 Background: Predictive biomarkers (BMs) for EGJAc would optimise treatment selection and avoid ineffective therapy. Metabolic response (MR) defined as &gt;35% decrease in tumour FDG Standardized Uptake Value (SUV) between day 0 &amp; 14 after starting chemotherapy has a high negative predictive value (95%) for response, but limited positive predictive value (50%). Combining molecular BMs with FDG-PET may optimise response prediction. We used global gene expression profiling (GEP) to identify molecular BMs that when combined with FDG-PET would improve predictive accuracy. Methods: 28 patients with locally advanced or metastatic EGJAc received platinum based chemotherapy (PBC). FDG PET CT scans were at day 0 and day 14 and GEP (Affymetrix ST1.0 Exon Genechips) on day 0 tumour biopsies. A tissue microarray comprising an independent set of 154 OGJAc who underwent surgery +/− neoadjuvant PBC was used with immunohistochemistry (IHC) for qualification of GEP results. Radiological response was assessed after 3/ 4 cycles of PBC by RECISTv1.1. Results: We identified a gene expression signature (86 genes) that separated FDG PET MR patients(&gt;35% fall SUV day 0 to14) into those that do and do not go on to have a RECIST response. In cross validation, this signature correctly predicted response in 28/28. Pathway analysis on GEP data identified potential novel mechanisms of response, including the Leptin pathway. Leptin mRNA was higher in FDG metabolic responders who did not have a RECIST response compared to those that did. In the independent set, high Leptin protein by IHC was strongly associated with lack of histopathologic response to neoadjuvant PBC (n=64, p=0.002). High Leptin expression also had a therapy independent prognostic effect with longer survival in the absence of histopathologic response or with no neoadjuvant PBC and in low Leptin patients poor survival was mitigated to a certain extent by neoadjuvant PBC (n=154, Kaplan-Mieier, log rank p=0.041 &amp; Cox MVA p=0.040). Conclusions: Molecular biomarkers (Leptin in particular) combine with FDG PET to optimise response prediction in EGJAc. Further investigation of this combined molecular and imaging approach is warranted.
Novel Agents Overcome the Adverse Prognosis Imparted by Compromised Renal Function in Patients with Multiple Myeloma
Authors: Mehul Patel, Taimur Sher, Sikander Ailawadhi, Terry Mashtare, Wei Tan, Pranay Soni, Gregory Wilding, Kena C Miller, Alice Mohr, Kelvin P. Lee, Asher Alban Chanan-Khan
Journal: Blood (2008)