tbuckley/cabot-search huggingface dataset:
Effect of Changing Work Stressors and Coping Resources on the Risk of Type 2 Diabetes: The OHSPIW Cohort Study
Authors: Yulong Lian, Qing Sun, Suzhen Guan, Hua Ge, Ning Tao, Yu Jiang, YanXia Zhang, Li Ning, Jing Xiao, Jiwen Liu
Journal: Diabetes Care (2017)

OBJECTIVE Little is known about the relationship between changing psychosocial work conditions and type 2 diabetes. We determined whether changing work stressors and coping resources affect the risk of type 2 diabetes. RESEARCH DESIGN AND METHODS In this prospective cohort (2003–2014) of 3,740 workers without diabetes (OHSPIW [Occupational Health Study of Petroleum Industry Workers]), participants completed an evaluation of work-related stress and coping resources and type 2 diabetes diagnosis at baseline and 12 years follow-up (two waves). The changes in work stressors and coping resources were measured with the Occupation Stress Inventory–Revised and the Instrument for Stress-Related Job Analysis (Version 6.0). Type 2 diabetes was diagnosed on the basis of an oral glucose tolerance test supplemented by physician report. RESULTS Increased task stressors (relative risk [RR] 1.57 [95% CI 1.03–2.63]) and decreased coping resources (RR 1.68 [95% CI 1.02–2.83]) were associated with risk of type 2 diabetes. The main risk factors were increased role overload, increased role insufficiency, increased physical environment stressors, decreased self-care, and decreased rational coping. Increased coping resources also had a buffering effect on increased task stressors and type 2 diabetes. CONCLUSIONS Changes in work stressors and coping resources have an influence on the risk for type 2 diabetes, highlighting the importance of preventive measures against adverse psychosocial work conditions and reduced coping resources for diabetes prevention in the workplace.
Abstract 11158: Trends in Heart Failure Hospitalizations Using Data From National Hospital Discharge Survey
Authors: Muhammad Bilal Munir, Michael S Sharbaugh, Floyd W Thoma, Muhammad Umer Nisar, Amir S Kamran, Andrew D Althouse, Samir Saba
Journal: Circulation (2016)

Aims: Heart failure (HF) is a common cause of hospital admission. However, relatively little data have described temporal trends in HF hospitalization. We present data on the number of HF admissions, length of stay and inpatient mortality from 1996-2010. Methods: Data were obtained from the National Hospital Discharge Survey (NHDS), a national probability sample survey of discharges conducted annually by the National Center for Health Statistics. Because of the survey design, sampling weights are applied to the raw NHDS data to produce national estimates. Hospitalizations with a primary diagnosis of HF were identified using ICD-9 codes. Weighted least squares regression was used to test for linear trends in the number of HF admissions, length of stay, and inpatient mortality. Results: The raw data contained 130,079 HF hospitalizations, translating to an estimated 16.7 million hospitalizations from 1996-2010 after application of sample weights. The total number of hospitalizations increased over time (p=0.05; see Figure); however, mean length of stay per hospitalization declined (p&lt;0.001; see Figure). Inpatient mortality rate has also declined (p&lt;0.001; see Figure). Conclusion: In a nationally representative sample of HF hospitalizations, mean length of stay and inpatient mortality rates have been declining over the past two decades. These trends reflect improvement in HF management over time, and have important implications in the cost of managing HF patients.
In adults, benzodiazepines were not linked to increased risk for mortality at 6 mo but were linked at 12 and 48 mo
Authors: Steven M. Belknap
Journal: Annals of Internal Medicine (2017)

ACP Journal Club19 December 2017In adults, benzodiazepines were not linked to increased risk for mortality at 6 mo but were linked at 12 and 48 moSteven M. Belknap, MD, FACP, FCPSteven M. Belknap, MD, FACP, FCPNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA (S.M.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2017-167-12-071 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationPatorno E, Glynn RJ, Levin R, Lee MP, Huybrechts KF. Benzodiazepines and risk of all cause mortality in adults: cohort study. BMJ. 2017;358:j2941. https://pubmed.ncbi.nlm.nih.gov/28684397Clinical Impact RatingsGIM/FP/GP: Mental Health: References1 Belknap SM. In adults, use of anxiolytic or hypnotic drugs was associated with increased risk for mortality [Comment]. Ann Intern Med. 2014;161:JC11. [PMID: 25023265] Google Scholar2 Weich S, Pearce HL, Croft P, et al. Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study. BMJ. 2014;348:g1996. [PMID: 24647164] Google Scholar3 Kripke DF, Langer RD, Kline LE. Hypnotics' association with mortality or cancer: a matched cohort study. BMJ Open. 2012;2:e000850. [PMID: 22371848] Google Scholar4 Kripke DF. Mortality risk of hypnotics: Strengths and limits of evidence. Drug Saf. 2016;39:93-107. [PMID: 26563222] Google Scholar Author, Article, and Disclosure InformationAffiliations: Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (S.M.B.)This article was published at Annals.org on 5 December 2017. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExposure to Latent Tuberculosis Treatment during Pregnancy. The PREVENT TB and the iAdhere Trials 19 December 2017Volume 167, Issue 12Page: JC71KeywordsAlgorithmsCohort studiesDatabasesDrugsHazard ratioHealth careMortalityPsychiatry and mental healthSafetySedatives ePublished: 19 December 2017 Issue Published: 19 December 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 14392: Endothelial Endoplasmic Reticulum Stress and Insulin Resistance in Patients With Diabetes Mellitus are Reduced by Liraglutide
Authors: Rosa Breton-Romero, Monika Holbrook, Jessica L Fetterman, Erika A Linder, Robert M Weisbrod, Melissa D Caitlin, Bihua Feng, Elica Inagaki, Noyan Gokce, Naomi M Hamburg
Journal: Circulation (2016)

Prior studies have shown that nutrient excess induces endoplasmic reticulum (ER) stress in nonvascular tissues in patients with diabetes mellitus (DM). Initially, ER stress and the subsequent unfol...
Abstract 235: Integration of Patient-specific Computational Hemodynamics and Vessel Wall Shear Stress Into MRI Diagnosis of Vascular Diseases
Authors: Huidan W Yu, Xi Chen, Zhiqiang Wang, Rou Chen, Chen Lin, Stephen F Kralik, Raveena Patil
Journal: Circulation Research (2016)

The research objective is to expand the capability of current MRI imaging technique in assessing the overall risk and predicted outcomes of atherosclerotic diseases through the quantification of individual patient-specific hemodynamics, including flow, pressure, and wall-shear stress. A unique computational modeling technique, named InVascular, is integrated directly into clinical MRI scanners as the extension of the image reconstruction and post-processing pipeline so that velocity, pressure, vorticity, and WSS can be available immediately with other diagnostic images. InVascular is a unified and GPU accelerated computation platform to model and simulate patient-specific hemodynamics and flow-vessel interaction based on MRI imaging data. In this study, we validate the efficiency and accuracy of InVascular through quantitative hemodynamics in vertebral and carotid arteries. A group of five volunteers participated in the scanning of high resolution time-of-flight (TOF) and low resolution electrocardiogram (ECG) gated phase contrast (PC) MR angiogram (MRA) images. For each case, InVascular successively processes the images to get vessel geometry from TOF MRA and velocity slices from PC MRA and solve the fluid dynamics inside the carotid arteries with PC MRA measured velocity at the inlet and outlet (Fig. 1 a-c). The velocity profiles from Invascular and PC MRA are compared at the same location (Fig. 1 d-g ). We conclude that integration of MRAs and InVascular can well captured the velocity fields as MRI measures. InVascular can provide quantitative pressure and WSS (Fig. 1h ) information as well.
3D models of EGFR-dependent breast cancer: mechanisms of activation, drug response and resistance
Authors: Paraic Kenny, Dinah Levy, Mina Bissell
Journal: Cancer Research (2007)

2227   While common in other epithelial tumors, mutations in components downstream of the EGFR such as Ras and Raf are rare in breast tumors. We have defined an autocrine loop in a model of human breast cancer progression consisting of two EGFR ligands, Amphiregulin and TGF-alpha, and a protease, TACE/ADAM17, which is essential for their activity. Targeting this protease using small molecule inhibitors or siRNAs results in a reversion of the malignant phenotype in this 3D culture model, phenocopying EGFR inhibition. Although TACE has many substrates, we demonstrate definitively that the reverting effect of TACE inhibition is a direct consequence of the inhibition of growth factor ectodomain shedding. Additionally, we report that response to small molecule EGFR inhibitors is significantly affected by EGFR ligand levels in the microenvironment suggesting that high levels of these proteins may contribute to EGFR inhibitor resistance. We further demonstrate a strong positive correlation between TACE and TGF-alpha expression in human breast tumors that is predictive of poor prognosis. TGF-alpha expression was strongly associated with tumors of the Basal sub-class, while Amphiregulin expression was associated with Estrogen Receptor positive tumors of the Luminal and Normal sub-classes. Using a panel of Estrogen Receptor positive breast cancer cell lines we show that Amphiregulin is a key target of estrogen receptor signaling. These data implicate TACE as a therapeutically tractable enzyme, the inhibition of which effectively blocks EGFR signaling by preventing mobilization of ligands for this receptor and suggest that co-ordinate inhibition of TACE may augment the activity of EGFR inhibitors in a clinical setting in tumors of the breast and other epithelial tissues.
The Red Parasol
Authors: M. Therese Southgate
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Melanoma Metastatic to the Duodenum
Authors: Themistoklis Kourkoumpetis, Maria E Jarbrink-Sehgal
Journal: New England Journal of Medicine (2017)

An 87-year-old man presented with a 3-week history of nausea, emesis, anorexia, and weight loss. Upper endoscopy identified three pigmented lesions, and melanoma was confirmed on biopsy.
Early-life House Dust and Infant Nasal Microbiota Similarity is Diminished in Infants who Develop Atopy
Authors: Kathryn McCauley, Douglas Fadrosh, Kole Lynch, Agustin Calatroni, Petra LeBeau, Hoang Tran, Homer A. Boushey, Daniel J. Jackson, James E. Gern, Susan V. Lynch
Journal: Journal of Allergy and Clinical Immunology (2018)
The Christmas gift of genetic uncertainty
Authors: Christopher Semsarian, Ray Moynihan
Journal: BMJ (2017)

John is a 32 year old father of two who had been troubled by excess earwax since childhood. Turning to “Dr Google” he thought that his type of earwax might be the result of a genetic change (single nucleotide polymorphism; SNP) in the ABCC11 gene, which can lead to either “dry earwax” or “wet earwax.” Having annoyed his family for many years, John’s father gave him a direct to consumer, ancestry based genetic test kit as a Christmas gift a couple of years ago; for fairness, he gave the same gift to his adult daughter, Rebecca.

Although this genetic gift was focused on providing information specifically about family and ethnic origins, John discovered that this genetic information—comprising thousands of SNPs across the genome—could also be uploaded to a free website to identify the genetic risk of many …
Trends in Country-Specific Surgical Randomized Clinical Trial Publications
Authors: Jared A. Forrester, Joseph D. Forrester, Sherry M. Wren
Journal: JAMA Surgery (2017)

Clinical Trial PublicationsHistorically, the United States was at the forefront of surgical discovery, as measured by publications and citations. 12][3] Randomized clinical trials (RCTs) are vital to discovery.We describe trends in country-specific surgical RCT publications in preeminent international journals to generate and inform the dialogue between surgical researchers and funding agencies in the United States.
Hypoglycemia in Hospice Patients With Type 2 Diabetes in a National Sample of Nursing Homes
Authors: Laura A. Petrillo, Siqi Gan, Bocheng Jing, Sean Lang-Brown, W. John Boscardin, Sei J. Lee
Journal: JAMA Internal Medicine (2017)

This retrospective cohort study examines whether patients with type 2 diabetes on hospice are assessed for dysglycemia, receive insulin or oral hypoglycemic medications, or experience hypoglycemia and hyperglycemia in the nursing home setting.
Advocacy as Key to Structural Competency in Psychiatry
Authors: Laurence J. Kirmayer, Rachel Kronick, Cécile Rousseau
Journal: JAMA Psychiatry (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression
Authors: Jung-Mi Lee, Vinothini Govindarajah, Bryan Goddard, Ashwini Hinge, David E. Muench, Marie-Dominique Filippi, Bruce Aronow, Jose A. Cancelas, Nathan Salomonis, H. Leighton Grimes, Damien Reynaud
Journal: The Journal of Experimental Medicine (2017)

Obesity is a chronic organismal stress that disrupts multiple systemic and tissue-specific functions. In this study, we describe the impact of obesity on the activity of the hematopoietic stem cell (HSC) compartment. We show that obesity alters the composition of the HSC compartment and its activity in response to hematopoietic stress. The impact of obesity on HSC function is progressively acquired but persists after weight loss or transplantation into a normal environment. Mechanistically, we establish that the oxidative stress induced by obesity dysregulates the expression of the transcription factor Gfi1 and that increased Gfi1 expression is required for the abnormal HSC function induced by obesity. These results demonstrate that obesity produces durable changes in HSC function and phenotype and that elevation of Gfi1 expression in response to the oxidative environment is a key driver of the altered HSC properties observed in obesity. Altogether, these data provide phenotypic and mechanistic insight into durable hematopoietic dysregulations resulting from obesity.
Chronic Traumatic Encephalopathy in Football Players
Authors: Scott L. Zuckerman, Benjamin L. Brett, Aaron M. Yengo-Kahn
Journal: JAMA (2017)

To the Editor The study of former professional football players diagnosed posthumously as having chronic traumatic encephalopathy (CTE) is the largest such study to date.1 The criterion used to diagnose CTE is a crucial limitation that necessitates further discussion.
Tolerability and activity of chemo-free triplet combination of TGR-1202, ublituximab, and ibrutinib in patients with advanced CLL and NHL.
Authors: Loretta J. Nastoupil, Matthew Alexander Lunning, Julie Vose, Marshall T. Schreeder, Tanya Siddiqi, Christopher Flowers, Jonathon Brett Cohen, Jan Andreas Burger, William G. Wierda, Susan Mary O'Brien, Peter Sportelli, Hari P. Miskin, Michelle A Purdom, Michael S. Weiss, Nathan Hale Fowler
Journal: Journal of Clinical Oncology (2017)

7511 Background: Novel targeted agents are emerging for B-cell malignancies, but few studies have safely combined these agents. Ublituximab (UTX) is a novel glycoengineered mAb targeting a unique epitope on the CD20 antigen. TGR-1202 is a next generation, once daily PI3Kδ inhibitor, demonstrating a favorable safety profile compared to prior inhibitors, including in long-term follow up (Burris, 2016). This Ph 1 trial evaluates the safety/efficacy of the triplet combination of a novel anti-CD20 mAb + PI3Kδ + BTK inhibitor (ibrutinib) in pts with B-cell malignancies. Methods: Eligible pts had CLL or rel/ref NHL w/o limit to prior therapies, including those ref to prior PI3Kδ or BTK inhibitors. UTX dosed on D1, 8, 15 of C1; D1 of C2-6, and C9 &amp; 12. TGR-1202 dose escalated (400/600/800mg QD), ibrutinib dosed at 420mg (CLL) or 560mg (NHL), both on C1D1. Results: 38 pts were enrolled: 20 CLL/SLL and 18 NHL, including 6 follicular (FL), 6 DLBCL, 4 mantle cell (MCL) and 2 marginal zone (MZL). Med age 65 yrs (range 32-85); 29 M/9 F; med prior tx = 3 (range 0-6). 2 pts were ref to prior PI3Kδ and 2 were prev treated with ibrutinib (1 ref/1 rel). MTD was not reached. Most common ( &gt; 20%) all causality AE’s were fatigue (42%), diarrhea (39%), dizziness (34%), nausea (32%), neutropenia, pyrexia, rash, infusion reaction, insomnia (each at 29%), thrombocytopenia, cough (each at 26%), anemia (24%) and sinusitis (21%). GR 3/4 AE’s were minimal, the only event &gt; 10% was neutropenia (16%). ORR amongst 36 evaluable pts is shown in the table below. 53% of evaluable CLL pts had high-risk cytogenetics and 4/6 DLBCL pts were non-GCB. One CLL pt (17p/11q del) ref to both PI3Kδ and ibrutinib achieved a CR. Med time on study is 10 mos (range 1 – 27+ mos). Med DOR not reached (range 3 – 24+ mos). Conclusions: This is the first known triple combination of an anti-CD20 mAb + PI3Kδ + BTK inhibitor. The combination of UTX, TGR-1202, and ibrutinib has been well tolerated with activity observed across heavily pre-treated and high-risk B-cell malignancies. Expansion cohorts at the highest dose (800mg TGR-1202 + full dose ibrutinib) are underway. Future trials for the triplet are warranted. Clinical trial information: NCT02006485. [Table: see text]
FibroScan і неінвазивні індекси в діагностиці неалкогольної жирової хвороби печінки
Authors: Yu.M. Stepanov, N.V. Nedzvetskaya, V.B. Yagmur, D.V. Popok, L.M. Shendrik
Journal: GASTROENTEROLOGY (2017)

Актуальність. Неалкогольна жирова хвороба печінки (НАЖХП) є самостійною нозологічною одиницею, характеризується накопиченням жиру в гепатоцитах, не пов’язаним зі зловживанням алкоголем, і включає широкий спектр порушень — від жирової дистрофії печінки, неалкогольного стеатогепатиту до фіброзу з можливим переходом у цироз печінки. З огляду на поширеність цієї патології, погіршення якості життя хворих, збільшення смертності від ускладнень зростає інтерес до розробки методів для точної й своєчасної оцінки фіброзу. Мета: порівняльна характеристика результатів транзієнтної еластометрії (FibroScan) і неінвазивних лабораторних індексів у визначенні фіброзної трансформації печінки у хворих із неалкогольною жировою хворобою печінки. Матеріали та методи. У дослідження включені пацієнти з НАЖХП, які проходили обстеження й лікування у відділенні захворювань печінки та підшлункової залози ДУ «Інститут гастроентерології НАМН України». Обстежені 42 пацієнти з НАЖХП, серед яких 18 (45 %) чоловіків і 24 (55 %) жінки. Усім пацієнтам було виконано розрахунок неінвазивних маркерів фіброзу печінки: APRI, FIB­4, співвідношення аланінамінотрансферази/аспартатамінотрансферази, проведено вимірювання жорсткості печінки за допомогою апарату FibroScan. Результати нашої роботи узгоджуються з більшістю досліджень, згідно з якими найбільш ефективним з малоінвазивних індексів є APRI. Висновки. Поєднання транзієнтної еластометрії (FibroScan) з індексом APRI може забезпечити більш ефективний підхід до діагностики фіброзу печінки у хворих з НАЖХП.