AB0963 Lipid abnormalities in children and adolescents with systemic lupus erythematosus
Authors: LF Bogmat, NS Shevchenko, IN Bessonova, VV Nikonova
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Systemic lupus erythematosus is an autoimmune disease that leads to the progressive destruction of the vital organs and systems, promotes early disability, premature mortality. The main reasons for the latest adult population of patients have complications of atherosclerotic vascular lesions stuch as the myocardial infarction and the stroke. The greatest effectiveness of preventive measures of the progression of atherosclerotic process and its associated cardiovascular complications determine the maximum early to start immediately after diagnosis in childhood and adolescence. <h3>Objectives</h3> To evaluate the lipid spectrum of the blood of children and adolescent patients with SLE. <h3>Methods</h3> It was been examined 26 persons 7–18 years with systemic lupus erythematosus, mostly female (88.46%), which were determined by the concentration of total cholesterol (total cholesterol), HDL cholesterol (HDL cholesterol), low density lipoprotein cholesterol (LDL), triglycerides (TG), calculated coefficient of the atherogenicity (CA = (total cholesterol - HDL cholesterol)/HDL cholesterol). Distribution groups conducted depending on the duration of the disease: the first consisted of 10 patients (38.46%) with a term of 1–3 years of the disease, the second - 16 people (61,54%) with duration of more than 3 years. The control group consisted of 10 healthy peers. <h3>Results</h3> Average lipid spectrum of the blood of patients did not exceed the reference values and had no statistical differences in the patients allocated to groups. However, in comparison with the control group the children with SLE had significant differences that reflect the peculiarities of formation of their metabolic disorders. Thus, total cholesterol and TG levels in both the first and the second groups were significantly higher than the control value and accounted for (5,02±0,26) mmol /L (5,24±0,26) mmol/L vs (3,39±0,20) mmol/L (p&lt;0, 05) and (1,64±0,54) mmol/L (1,45±0,19) mmol/L vs (0,72±0,08) mg /L (p&lt;0.05), respectively. Similar changes had occurred with parameters of LDL cholesterol, which significantly increased among patients with disease duration of 1–3 years ((3,08±0,26) mmol/L vs (1,73±0,03) mg/dL in the control group; p&lt;0.05) and reached biggest values in patients with SLE over the course of 3 years ((3,57±0,82) mmol/l, p&lt;0.05). In parallel, the concentration of HDL cholesterol patients of the second group decreased ((1,38±0,06) mmol/L vs (1,51±0,08) mg/dL healthy subjects, p&lt;0.1), the consequence was significant increase in their spacecraft ((2,79±0,69) conv. units. against (1,24±0,17) conv. units. in comparison group, p&lt;0.05). In addition, patients with SLE found a direct correlation of total cholesterol blood of disease activity, confirmed a direct correlation (r =0,632; p&lt;0.05). <h3>Conclusions</h3> Thus, changes of blood lipid profile in the SLE patients occur in the early stages of the disease in childhood and adolescence, have the atherogenic focus, which compounded with increasing the duration and disease activity. <h3>Disclosure of Interest</h3> None declared