tbuckley/cabot-search huggingface dataset:
Inflammatory Biomarkers and Risk of Schizophrenia
Authors: Fernando Pires Hartwig, Maria Carolina Borges, Bernardo Lessa Horta, Jack Bowden, George Davey Smith
Journal: JAMA Psychiatry (2017)

Positive associations between inflammatory biomarkers and risk of psychiatric disorders, including schizophrenia, have been reported in observational studies. However, conventional observational studies are prone to bias, such as reverse causation and residual confounding, thus limiting our understanding of the effect (if any) of inflammatory biomarkers on schizophrenia risk.To evaluate whether inflammatory biomarkers have an effect on the risk of developing schizophrenia.Two-sample mendelian randomization study using genetic variants associated with inflammatory biomarkers as instrumental variables to improve inference. Summary association results from large consortia of candidate gene or genome-wide association studies, including several epidemiologic studies with different designs, were used. Gene-inflammatory biomarker associations were estimated in pooled samples ranging from 1645 to more than 80 000 individuals, while gene-schizophrenia associations were estimated in more than 30 000 cases and more than 45 000 ancestry-matched controls. In most studies included in the consortia, participants were of European ancestry, and the prevalence of men was approximately 50%. All studies were conducted in adults, with a wide age range (18 to 80 years).Genetically elevated circulating levels of C-reactive protein (CRP), interleukin-1 receptor antagonist (IL-1Ra), and soluble interleukin-6 receptor (sIL-6R).Risk of developing schizophrenia. Individuals with schizophrenia or schizoaffective disorders were included as cases. Given that many studies contributed to the analyses, different diagnostic procedures were used.The pooled odds ratio estimate using 18 CRP genetic instruments was 0.90 (random effects 95% CI, 0.84-0.97; P = .005) per 2-fold increment in CRP levels; consistent results were obtained using different mendelian randomization methods and a more conservative set of instruments. The odds ratio for sIL-6R was 1.06 (95% CI, 1.01-1.12; P = .02) per 2-fold increment. Estimates for IL-1Ra were inconsistent among instruments, and pooled estimates were imprecise and centered on the null.Under mendelian randomization assumptions, our findings suggest a protective effect of CRP and a risk-increasing effect of sIL-6R (potentially mediated at least in part by CRP) on schizophrenia risk. It is possible that such effects are a result of increased susceptibility to early life infection.
TCT-831 Results of left main percutaneous coronary intervention with zotarolimus eluting stent at a very long-term follow-up
Authors: Ignacio Sanchez-Perez, Jesus Piqueras-Flores, Fernando Lozano, María Thiscal López Lluva, Natalia Pinilla-Echeverri, Ramón Maseda Uriza, Alfonso Jurado-Román
Journal: Journal of the American College of Cardiology (2017)
Abstract 15154: T1-mapping and Outcomes in Non-ischemic Cardiomyopathies- An Investigator-led Multicenter Observational Longitudinal Study
Authors: Valentina O Puntmann, Gerry Carr-White, Andrew Jabbour, Chung-Yao Yu, Rolf Gebker, Sebastian Kelle, Rocio Hinojar, Ada Doltra, Niharika Varma, Nick Child, Toby Rogers, Eduardo Arroyo Ucar, Ben Goodman, Gonca Suna, Sitara Khan, Darius Dabir, Eva Herrmann, Andreas M Zeiher, Eike Nagel
Journal: Circulation (2015)

Introduction: Nonischemic cardiomyopathy (NICM) is a recognised cause of poor clinical outcome. NICM is characterised by intrinsic myocardial impairment, which is driven by interstitial myocardial fibrosis in a considerable majority of NICM. The lack of accurate and noninvasive characterisation of interstitial myocardial fibrosis limits recognition of disease and effective clinical management in NICM. Hypothesis: T1 mapping by CMR is a novel non-invasive imaging application with a recognized potential to significantly improve the management of patients with NICM, supporting characterization of interstitial myocardial disease, assessment of severity of disease, risk stratification as well as development of targeted therapies. Comparative prognostic relevance of T1-mapping parameters in subjects with NICM for adverse outcome is unknown. Methods: an investigator-led multicenter observational longitudinal study in patients with NICM. We standardized imaging acquisition based on the modified Look-Locker sequence (MOLLI) (3(3)3(3)5) and post-processing approach of T1 mapping, and transferred the methodology to several other centres. We determined reference ranges for T1 mapping values and provided proof of concept studies in NICM in discrimination between health and disease. The primary endpoint was all-cause mortality. Results: 805 consecutive patients (mean age (years) 50±16; males: n=499, 62%) with NICM underwent contrast-enhanced CMR with T1-mapping. During a median follow-up period of 17 months (range 36 months), we observed a total of 26 deaths (18 cardiac). Native T1, ECV and extent of LGE were strongly associated with an increased likelihood of all-cause mortality (p&lt;0.001). In multivariate analyses, native T1 was the sole independent predictor of all-cause and cardiac mortality, over and above ECV and LGE. Native T1 was also superior in correctly classifying subjects and adverse events over a 17-months period. Conclusions. In patients with NICM, non-invasive measures of interstitial myocardial fibrosis are useful in prediction of outcome. Native T1 is an independent predictor over and above conventional markers of risk, providing a basis for a novel algorithm of risk stratification in NICM.
Attitude–Scenario–Emotion (ASE) sentiments are superficial
Authors: Heather Adair, Peter Carruthers
Journal: Behavioral and Brain Sciences (2017)

Abstract Gervais &amp; Fessler's (G&amp;F's) Attitude–Scenario–Emotion (ASE) model reduces sentiments to superficial patterns of emotional responding that emerge when an underlying evaluative attitude interacts with appraisals of a range of specific scenarios. Thus construed, sentiments are epiphenomenal. We argue that G&amp;F would do better to identify each sentiment (love, say) with the attitude that underlies and explains the patterns of emotional responding (in the case of love, this might be the attitude of valuing the good of a specific other).
Neutrophil to lymphocyte ratio (NLR) as an early marker for outcome in patients treated with nivolumab in advanced NSCLC
Authors: Aya Nakaya, Maiko Niki, Takashi Yokoi, Yuki Takeyasu, Kayoko Kibata, Makoto Ogata, Yoshitaro Torii, Takayasu Kurata, Shosaku Nomura
Journal: Annals of Oncology (2017)
Mechanisms of Very Late Bioresorbable Scaffold Thrombosis
Authors: Kyohei Yamaji, Yasushi Ueki, Geraud Souteyrand, Joost Daemen, Jens Wiebe, Holger Nef, Tom Adriaenssens, Joshua P. Loh, Benoit Lattuca, Joanna J. Wykrzykowska, Josep Gomez-Lara, Leo Timmers, Pascal Motreff, Petra Hoppmann, Mohamed Abdel-Wahab, Robert A. Byrne, Felix Meincke, Niklas Boeder, Benjamin Honton, Crochan J. O’Sullivan, Alfonso Ielasi, Nicolas Delarche, Günter Christ, Joe K.T. Lee, Michael Lee, Nicolas Amabile, Alexios Karagiannis, Stephan Windecker, Lorenz Räber
Journal: Journal of the American College of Cardiology (2017)
Motivating Health Behaviors in Adolescents Through Behavioral Economics
Authors: Shelagh Mulvaney, Joyce M. Lee
Journal: JAMA Pediatrics (2017)

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Late-Onset ADHD Reconsidered With Comprehensive Repeated Assessments Between Ages 10 and 25
Authors: Margaret H. Sibley, Luis A. Rohde, James M. Swanson, Lily T. Hechtman, Brooke S.G. Molina, John T. Mitchell, L. Eugene Arnold, Arthur Caye, Traci M. Kennedy, Arunima Roy, Annamarie Stehli
Journal: American Journal of Psychiatry (2017)

Objective: Adolescents and young adults without childhood attention deficit hyperactivity disorder (ADHD) often present to clinics seeking stimulant medication for late-onset ADHD symptoms. Recent birth-cohort studies support the notion of late-onset ADHD, but these investigations are limited by relying on screening instruments to assess ADHD, not considering alternative causes of symptoms, or failing to obtain complete psychiatric histories. The authors address these limitations by examining psychiatric assessments administered longitudinally to the local normative comparison group of the Multimodal Treatment Study of ADHD. Method: Individuals without childhood ADHD (N=239) were administered eight assessments from comparison baseline (mean age=9.89 years) to young adulthood (mean age=24.40 years). Diagnostic procedures utilized parent, teacher, and self-reports of ADHD symptoms, impairment, substance use, and other mental disorders, with consideration of symptom context and timing. Results: Approximately 95% of individuals who initially screened positive on symptom checklists were excluded from late-onset ADHD diagnosis. Among individuals with impairing late-onset ADHD symptoms, the most common reason for diagnostic exclusion was symptoms or impairment occurring exclusively in the context of heavy substance use. Most late-onset cases displayed onset in adolescence and an adolescence-limited presentation. There was no evidence for adult-onset ADHD independent of a complex psychiatric history. Conclusions: Individuals seeking treatment for late-onset ADHD may be valid cases; however, more commonly, symptoms represent nonimpairing cognitive fluctuations, a comorbid disorder, or the cognitive effects of substance use. False positive late-onset ADHD cases are common without careful assessment. Clinicians should carefully assess impairment, psychiatric history, and substance use before treating potential late-onset cases.
Man posed as psychiatrist in German hospital for over a year
Authors: Ned Stafford
Journal: BMJ (2017)

A 38 year old man with psychosis and paranoid schizophrenia and no medical qualifications used forged documents to obtain a position as an assistant doctor in the psychiatric ward of a German hospital, where he worked for 15 months before the fraud was discovered.

The documents, which he forged himself, falsely indicated that he had qualified in medicine at Donetsk National University in Ukraine, said the national newspaper Bild , which uncovered the deception.1

The man, who has not been named in the German press, was involved in another major fraud a decade ago. In that case, he forged documents indicating …
TCT-356 Decreasing the Hazards of Radiation Dose Exposure in Patient Undergoing Percutaneous Coronary Interventions (PCI) for the Treatment of Chronic Total Occlusion. A Prospectively Evaluated Radiation Protocol
Authors: Austin Hamlin, Kendall Parris, Amber Petrohovich, Emilio Exaire, Luis Guzman
Journal: Journal of the American College of Cardiology (2017)
A Missense Variant in PLEC Increases Risk of Atrial Fibrillation
Authors: Rosa B. Thorolfsdottir, Gardar Sveinbjornsson, Patrick Sulem, Anna Helgadottir, Solveig Gretarsdottir, Stefania Benonisdottir, Audur Magnusdottir, Olafur B. Davidsson, Sridharan Rajamani, Dan M. Roden, Dawood Darbar, Terje R. Pedersen, Marc S. Sabatine, Ingileif Jonsdottir, David O. Arnar, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hilma Holm, Kari Stefansson
Journal: Journal of the American College of Cardiology (2017)
Comma hairs: A dermatoscopic marker for tinea capitis
Authors: Monika Slowinska, Lidia Rudnicka, Robert A. Schwartz, Elzbieta Kowalska-Oledzka, Adriana Rakowska, Justyna Sicinska, Malgorzata Lukomska, Malgorzata Olszewska, Elzbieta Szymanska
Journal: Journal of the American Academy of Dermatology (2008)
Extracellular Vesicles in Cardiovascular Theranostics
Authors: Yihua Bei, Saumya Das, Rodosthenis S. Rodosthenous, Paul Holvoet, Maarten Vanhaverbeke, Marta Chagas Monteiro, Valter Vinicius Silva Monteiro, Jana Radosinska, Monika Bartekova, Felix Jansen, Qian Li, Johnson Rajasingh, Junjie Xiao
Journal: Theranostics (2017)

Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids.EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells.Increasing evidence has shown the important regulatory effects of EVs in cardiovascular diseases (CVDs).EVs secreted by cardiomyocytes, endothelial cells, fibroblasts, and stem cells play essential roles in pathophysiological processes such as cardiac hypertrophy, cardiomyocyte survival and apoptosis, cardiac fibrosis, and angiogenesis in relation to CVDs.In this review, we will first outline the current knowledge about the physical characteristics, biological contents, and isolation methods of EVs.We will then focus on the functional roles of cardiovascular EVs and their pathophysiological effects in CVDs, as well as summarize the potential of EVs as therapeutic agents and biomarkers for CVDs.Finally, we will discuss the specific application of EVs as a novel drug delivery system and the utility of EVs in the field of regenerative medicine.
Les vagues de chaleur de 2003 en Europe
Authors: T Kosatsky
Journal: Eurosurveillance (2005)

Le numero suivant d’Eurosurveillance fournit les mises a jour et presente le contexte d’un exces estime de 22 080 deces pour l’Angleterre et le Pays de Galles, la France, l’Italie et le Portugal, pendant et aussitot apres les vagues de chaleur de l’ete 2003 [1], rapporte debut 2004. Alors que les estimations pour l’Angleterre et le Pays de Galles [2], la France [3] et le Portugal [4] n’ont pratiquement pas varie comparees aux chiffres annonces precedemment, il faut y ajouter 6595-8648 morts en exces pour l’Espagne [5], dont 54% environ, soit entre 3574 et 4687, sont survenues au mois d’aout, ainsi que 1400-2200 aux Pays-Bas [6], dont 500 estimees ont eu lieu pendant la vague de chaleur du 31 juillet au 13 aout. Les donnees pour l’Italie, concernant ici Bologne, Milan, Rome et Turin, tendent a confirmer les estimations anterieures, de 3134 deces dans les 21 capitales regionales pour la periode du 1er juin au 15 aout [7] ; cependant l’Institut national italien de statistiques a rapporte un exces de 19 780 deces pour l’ensemble du pays entre juin et septembre 2003 compare a 2002 [8]. D’autres etudes mentionnent environ 1250 deces lies a la canicule en Belgique pendant l’ete 2003 [9], un exces de 975 deces entre juin et aout en Suisse [10], et de 1410 pendant la periode du 1er au 24 aout a Baden-Wurttemberg, Allemagne [11]. A l’heure actuelle, on peut raisonnablement supposer qu’avec la confirmation des deces associes a la vague de chaleur entre l’Angleterre et le Pays de Galles, la France, l’Italie et le Portugal, le chiffre estime de 22 080 morts en exces debut aout devrait etre revu a la hausse et augmente de 50% pour toute l’Europe occidentale. Cette augmentation pourrait etre portee jusqu’a 100% si les episodes de canicule de juin et juillet 2003 etaient egalement pris en compte.
TCT-83 Provisional vs. Planned Two-stent Technique in Patients with Distal Bifurcation Left Main Disease Undergoing PCI: The EXCEL Trial
Authors: David Kandzari, Anthony Gershlick, Patrick Serruys, Martin Leon, Marie-Claude Morice, Nicholas Lembo, Adrian Banning, Ad van Boven, Imre Ungi, A. Pieter Kappetein, Joseph Sabik, Ovidiu Dressler, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
8,4′-Oxyneolignane glucosides from an aqueous extract of “ban lan gen” ( Isatis indigotica root) and their absolute configurations
Authors: Lingjie Meng, Qinglan Guo, Yufeng Liu, Jiangong Shi
Journal: Acta Pharmaceutica Sinica B (2017)

Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A−F (1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of ΔδC8-C7 values to distinguish threo and erythro aryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in 1–6 and their aglycones (1a–6a) are discussed.
TCT-47 Morphological Difference of Culprit Lesions by Age and Gender Assessed by Optical Coherence Tomography
Authors: Mitsuaki Matsumura, Gary Mintz, Tetsumin Lee, Masahiro Hoshino, Eisuke Usui, Yoshihisa Kanaji, Tadashi Murai, Taishi Yonetsu, Tsunekazu Kakuta, Akiko Maehara
Journal: Journal of the American College of Cardiology (2017)
The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes
Authors: Olivia S. Rissland, Alexander O. Subtelny, Miranda Wang, Andrew Lugowski, Beth Nicholson, John D. Laver, Sachdev S. Sidhu, Craig A. Smibert, Howard D. Lipshitz, David P. Bartel
Journal: Genome biology (2017)

All mRNAs are bound in vivo by proteins to form mRNA–protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored. Here, we have analyzed, on a transcriptome-wide scale, how microRNA-mediated repression modulates the associations of the core mRNP components eIF4E, eIF4G, and PABP and of the decay factor DDX6 in human cells. Despite the transient nature of repressed intermediates, we detect significant changes in mRNP composition, marked by dissociation of eIF4G and PABP, and by recruitment of DDX6. Furthermore, although poly(A)-tail length has been considered critical in post-transcriptional regulation, differences in steady-state tail length explain little of the variation in either PABP association or mRNP organization more generally. Instead, relative occupancy of core components correlates best with gene expression. These results indicate that posttranscriptional regulatory factors, such as microRNAs, influence the associations of PABP and other core factors, and do so without substantially affecting steady-state tail length.
Patient perspectives on telephone first system
Authors: Denis Pereira Gray, Patricia Wilkie
Journal: BMJ (2017)

As representatives of a major patient charity, we think that Newbould and colleagues have seriously undervalued the adverse effects that patients experience and the extra hospital costs incurred with telephone first consultations in general practice.1

A 4% immediate rise in hospital admissions for (potentially preventable) ambulatory care sensitive conditions, which increases thereafter, is bad for patients. Similarly, the ESTEEM study reported a 22.2% rise …
TCT-482 The comparison of usefulness of bioresorbable polymer-everolimus eluting stent with platinum chromium-everolimus eluting stent and everolimus-eluting stent in patients with the end-stage chronic kidney disease including hemodialysis
Authors: Takao Sato, Shohei Kishi, Katsuharu Hatada, Masaaki Okabe
Journal: Journal of the American College of Cardiology (2017)
TCT-87 Transcatheter Pledget-Assisted Suture Tricuspid Annuloplasty (PASTA)
Authors: Jaffar Khan, Toby Rogers, William Schenke, Adam Greenbaum, Vasilis Babaliaros, Gaetano Paone, Rajiv Ramasawmy, Marcus Chen, Daniel Herzka, Robert Lederman
Journal: Journal of the American College of Cardiology (2017)
Un'epidemia di legionellosi in un comune del nord del Portogallo
Authors: A M Correia, G Gonçalves, J Reis, J M Cruz, J A Castro e Freitas
Journal: Eurosurveillance (2001)

In un ospedale di distretto del nord del Portogallo sono stati ricoverati 11 pazienti, tutti residenti nello stesso comune, affetti da legionellosi. Dalle prime indagini e risultata una associazione con le manifestazioni della festa annuale del paese. Non e stata isolata Legionella pneumophila da nessuna delle fonti sospette, ma uno studio caso-controllo ha suggerito come probabile veicolo dell'infezione l'aerosol prodotto da una fontana della piazza principale, durante la notte di un concerto rock. La prevalenza di fumatori era piu alta tra i casi che tra i controlli.
Resposta a um caso suspeito de Difteria em Dordrecht, Holanda
Authors: J. E. van Steenbergen, A Leentvaar-Kuijpers, J H C T van den Kerkhof
Journal: Eurosurveillance (1996)

Cerca de 25 000 ­ 50 000 refugiados buscam asilo na Holanda todos os anos. Apos uma avaliacao judicial, 85 a 90% deles sao transferidos para um dos 14 centros de recepcao, onde as criancas e os idosos sao inspeccionados medicamente e os restantes no que respeita a Tuberculose. O estado vacinal das criancas menores de 18 anos e avaliado e actualizado em funcao do plano vacinal holandes (difteria­tosse convulsa, tetano, Polio inactivada, Parotidite, Sarampo e Rubeola (MMR) e ainda o BCG para todos os refugiados. Cerca de quatro meses mais tarde os refugiados sao transferidos para um dos 14 centros ou residencias, onde podem ficar mais um ou dois anos ate terem garantido o seu estatuto. A partir de entao, sao assistidos na procura de habitacao propria.
La notifica dell'HIV in Europa occidentale: sistemi nazionali e primi dati europei
Authors: A Infuso, F F Hamers, A M Downs, J Alix
Journal: Eurosurveillance (2000)

In Europa occidentale, la notifica dei casi di AIDS ha costituito uno strumento essenziale per monitorare l'infezione da HIV. Le tendenze recenti dell'incidenza dell'AIDS sono state influenzate dal miglioramento nelle terapie antiretrovirali, che ritardano la progressione della malattia da HIV, e non sono piu utili come indicatori delle tendenze della trasmissione dell'HIV. La notifica di tutte le infezioni da HIV diagnosticate e considerata sempre di piu una componente essenziale della sorveglianza (1). Nel 1999, e stato organizzato un sistema di notifica europeo dell’infezione da HIV comprendente 39 paesi della regione europea dell'Organizzazione Mondiale per la Sanita (OMS) per integrare le notifiche di AIDS. Quest'articolo descrive i sistemi nazionali di notifica dell'HIV nei paesi dell'Europa occidentale e presenta i primi dati raccolti.
TCT-452 High Wall Shear Stress was Strongly Associated with Plaque Vulnerability in Computational Fluid Dynamics with Combined Optical Coherence Tomography and Heartflow FFRCT Simulation
Authors: Takayoshi Toba, Gilwoo Choi, Yuichiro Nagano, Hiroyuki Kawamori, Toshiro Shinke, Charles Taylor, Hiromasa Otake
Journal: Journal of the American College of Cardiology (2017)