tbuckley/cabot-search huggingface dataset:
Abstract 2637: Expression of SALL4 in prostate cancer
Authors: Dhafer A. Alghezi, Paul Whitley, Mark Beresford, Rebecca Bowen, John Mitchard, Andrew Chalmers
Journal: Cancer Research (2018)

Abstract Few prognostic biomarkers for Prostate cancer have been identified and there are clinical difficulties in distinguishing between relapsing and non-relapsing disease. The aim of our study is to investigate the hypothesis that proteins that have been linked to stem cells might be potential biomarkers, that could distinguish between aggressive tumors requiring radical intervention and those that have a good prognosis. One of the potential biomarkers that are being investigated is Sall4, a zinc finger transcriptional factor which has an important role in stem cell development and oncogeneses, including a possible role in prostate cancer progression and relapse. However, its role in prostate cancer remains unclear. Sall4 nuclear staining has been evaluated by immunohistochemistry using two sources of patient samples, a tissue microarray group and a Bath cohort. The tissue microarray group consists of 96 cases including normal prostate, adjacent normal prostate, and prostate cancer samples. The Bath cohort consists of 22 samples, including samples from patients that had recurrent disease and those who remained disease free. Sall4 nuclear staining was found to be decreased in prostate cancer samples compared to benign tissue from the tissue microarray group. Sall4 nuclear staining was also negatively associated with poorly differentiated grades of prostate cancer in the tissue microarray group. The Bath cohort did not have enough benign tissues to confirm the relationship between cancer and benign tissues but showed a negative association with the grade. Sall4 nuclear staining in tissue from both sets of samples was not associated with prostate cancer stages. It can be seen from this preliminary data that Sall4 might play an important role in tumor formation and/or aggressiveness and warrants further investigation to understand its function and establish if it could represent a potential diagnostic biomarker for prostate cancer. Citation Format: Dhafer A. Alghezi, Paul Whitley, Mark Beresford, Rebecca Bowen, John Mitchard, Andrew Chalmers. Expression of SALL4 in prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2637.
Abstract 17006: Is White Rice Consumption a Risk for Cardiovascular Disease? A Systematic Review and Meta-analysis
Authors: Chayakrit Krittanawong, Anusith Tunhasiriwet, Kimberly J Bisanz, HongJu Zhang, Tweet S Marysia, Larry J Prokop, Sakkarin Chirapongsathorn, Zhen Wang, Sharonne N Hayes
Journal: Circulation (2015)

Introduction: Current proposed Dietary Guidelines for Americans, 2015 suggested replacing refined grains (e.g., white rice) with whole grains (e.g., brown rice) for improved health outcomes; however, the association between white rice consumption and risk of cardiovascular disease (CVD) was not fully investigated. The purpose of this study was to explore the associations between rice consumption, metabolic syndrome and cardiovascular disease. Methods: We conducted a comprehensive search of MEDLINE, MEDLINE In-Process &amp; Other Non-Indexed Citations, EMBASE, Scopus, and the Cochrane Central Register of Controlled Trials from database inception through May 2015. Observational studies were included if the studies reported hazard ratios (HRs) or odd ratios (ORs) of the associations between rice consumption, metabolic syndrome and cardiovascular disease. Data were extracted by one reviewer and then reviewed by two independent reviewers. Conflicts were resolved through consensus. Using the DerSimonian and Laird random effects models, we calculated pooled HRs and pooled ORs with 95% confidence intervals (95% CIs). Subgroup analyses were performed to explore potential sources of heterogeneity. The quality of the included studies and publication bias were assessed. Results: Out of 343 retrieved articles, we identified 6 cross-sectional and 9 prospective studies with a total of 575,852 individuals with 24,649 total CVD events and 4,409 metabolic syndrome cases. The highest category of white rice consumption (≥5 times/week) was associated with a 37% higher risk of metabolic syndrome (pooled OR, 1.37; 95% CI: 1.03-1.84; p&lt;0.001; I 2 = 78.7%) but not a higher risk of cardiovascular disease (pooled HR, 1.01; 95% CI: 0.95-1.08; p=0.65; I 2 = 0%), compared to the lowest category (≤1 time/month). Conclusions: Higher white rice consumption has not been shown to increase the risk of cardiovascular diseases but may be associated with increased risk of metabolic syndrome.
High-Throughput Screening of Combinatorial Immunotherapies with Patient-Specific <i>In Silico</i> Models of Metastatic Colorectal Cancer
Authors: Jakob Nikolas Kather, Pornpimol Charoentong, Meggy Suarez-Carmona, Esther Herpel, Fee Klupp, Alexis Ulrich, Martin Schneider, Inka Zoernig, Tom Luedde, Dirk Jaeger, Jan Poleszczuk, Niels Halama
Journal: Cancer Research (2018)

Abstract Solid tumors are rich ecosystems of numerous different cell types whose interactions lead to immune escape and resistance to immunotherapy in virtually all patients with metastatic cancer. Here, we have developed a 3D model of human solid tumor tissue that includes tumor cells, fibroblasts, and myeloid and lymphoid immune cells and can represent over a million cells over clinically relevant timeframes. This model accurately reproduced key features of the tissue architecture of human colorectal cancer and could be informed by individual patient data, yielding in silico tumor explants. Stratification of growth kinetics of these explants corresponded to significantly different overall survival in a cohort of patients with metastatic colorectal cancer. We used the model to simulate the effect of chemotherapy, immunotherapies, and cell migration inhibitors alone and in combination. We classified tumors according to tumor and host characteristics, showing that optimal treatment strategies markedly differed between these classes. This platform can complement other patient-specific ex vivo models and can be used for high-throughput screening of combinatorial immunotherapies. Significance: This patient-informed in silico tumor growth model allows testing of different cancer treatment strategies and immunotherapies on a cell/tissue level in a clinically relevant scenario. Cancer Res; 78(17); 5155–63. ©2018 AACR.
Finding Means to Fulfill the Societal and Academic Imperative for Open Data Access and Sharing
Authors: Eric D. Peterson, Frank W. Rockhold
Journal: JAMA Cardiology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Abstract 9568: Adipose-Derived Mesenchymal Stem Cells Embedded in Platelet-Rich Fibrin Scaffolds Promote Angiogenesis, Preserve Heart Function, and Reduce Left Ventricular Remodeling in Rat Acute Myocardial Infarction
Authors: Jiunn-Jye Sheu, Sarah Chua, Tzu -Hsien Tsai, Hon-Kan Yip
Journal: Circulation (2013)

Background: This study tested the hypothesis that autologous adipose-derived mesenchymal stem cells (ADMSCs) embedded in platelet-rich fibrin (PRF) promotes myocardial regeneration and repair after acute myocardial infarction (AMI). Methods and Results: Adult male Sprague-Dawley rats equally divided (n=10/group) into group 1 (sham-operated), group 2 (AMI by ligating left coronary artery), group 3 (AMI+PRF), and group 4 (AMI+PRF-embedded autologous ADMSCs) were sacrificed on day 42 after AMI. Left ventricular (LV) dimension, infarct/fibrotic areas, and distance between I bands were lowest in group 1, highest in group 2, higher in group 3 than in group 4, whereas LV performance and wall thickness exhibited a reversed pattern (p&lt;0.001). Protein expressions of inflammatory (MMP-9, IL-1β), oxidative, apoptotic (Bax, cleaved-PARP), fibrotic (Smad 3, TFG-β), hypertrophic (β-MHC), and heart failure (BNP) biomarkers displayed an identical pattern in infarct/fibrotic areas, whereas protein expressions of anti-inflammatory (IL-10), anti-apoptotic (Bcl-2), anti-fibrotic (Smad1/5, BMP-2) biomarkers, and α-MHC showed an opposite pattern (p&lt;0.01). Angiogenic activities (Small-vessel numbers; C-kit+, Sca-1+, CD31+, SDF-1α+, CXCR4+ cells; protein expressions of SDF-1α, CXCR4, VEGF) were highest in group 4 and lowest in group 1, higher in group 3 than in group 2 (p&lt;0.001). Conclusion: ADMSCs embedded in PRF offered significant benefit in preserving LV function after AMI.
Role of sphingolipids in senescence: implication in aging and age-related diseases
Authors: Magali Trayssac, Yusuf A Hannun, Lina M Obeid
Journal: Journal of Clinical Investigation (2018)

Aging is defined as the progressive deterioration of physiological function with age. Incidence of many pathologies increases with age, including neurological and cardiovascular diseases and cancer. Aging tissues become less adaptable and renewable, and cells undergo senescence, a process by which they “irreversibly” stop dividing. Senescence has been shown to serve as a tumor suppression mechanism with clear desirable effects. However, senescence also has deleterious consequences, especially for cardiovascular, metabolic, and immune systems. Sphingolipids are a major class of lipids that regulate cell biology, owing to their structural and bioactive properties and diversity. Their involvement in the regulation of aging and senescence has been demonstrated and studied in multiple organisms and cell types, especially that of ceramide and sphingosine-1-phosphate; ceramide induces cellular senescence and sphingosine-1–phosphate delays it. These discoveries could be very useful in the future to understand aging mechanisms and improve therapeutic interventions.
Comparison of Dual β-Lactam therapy to penicillin-aminoglycoside combination in treatment of Enterococcus faecalis infective endocarditis
Authors: Abdelghani El Rafei, Daniel C. DeSimone, Aalap D. Narichania, M. Rizwan Sohail, Holenarasipur R. Vikram, Zhuo Li, James M. Steckelberg, Walter R. Wilson, Larry M. Baddour
Journal: Journal of Infection (2018)
Association of Midlife Cardiorespiratory Fitness With Incident Depression and Cardiovascular Death After Depression in Later Life
Authors: Benjamin L. Willis, David Leonard, Carolyn E. Barlow, Scott B. Martin, Laura F. DeFina, Madhukar H. Trivedi
Journal: JAMA Psychiatry (2018)

Cardiorespiratory fitness (hereinafter referred to as fitness) as estimated by exercise testing is a modifiable risk factor independently associated with chronic diseases, cardiovascular disease (CVD) events, and mortality, but the association of fitness at midlife with incidence of later-life depression and the risk of CVD mortality after a depression diagnosis is unknown.To determine whether fitness measured in midlife would be inversely associated with later-life CVD mortality with antecedent depression.This retrospective cohort study at a single-center, community-based preventive medicine clinic was performed as part of the Cooper Center Longitudinal Study. Data were collected from January 13, 1971, through December 31, 2009, and analyzed from October 6, 2015, through August 14, 2017. Participants included generally healthy men and women who presented for preventive medicine examinations at midlife and who were eligible for Medicare from 1999 to 2010. Those with a self-reported history of depression, myocardial infarction, or stroke at examination were excluded.Objective midlife fitness estimated from results of treadmill exercise testing.Depression diagnosis from Medicare claims files using established algorithms and CVD mortality from National Death Index records.A total of 17 989 participants (80.2% men) with a mean (SD) age of 50.0 (8.7) years were included. After 117 218 person-years of Medicare follow-up, 2701 depression diagnoses, 610 deaths due to CVD without prior depression, and 231 deaths due to CVD after depression were observed. A high level of fitness in midlife was associated with a 16% lower risk of depression (hazard ratio [HR], 0.84; 95% CI, 0.74-0.95) compared with a low level of fitness. A high fitness level was also associated with a 61% lower risk of death due to CVD without depression (HR, 0.39; 95% CI, 0.31-0.48) compared with a low level of fitness. After a diagnosis of depression, a high fitness level was associated with a 56% lower risk of death due to CVD (HR, 0.44; 95% CI, 0.31-0.64) compared with a low fitness level.Midlife fitness is associated with a lower risk of later-life depression, CVD mortality, and CVD mortality after incident later-life depression. These findings suggest the importance of midlife fitness in primary prevention of depression and subsequent CVD mortality in older age and should encourage physicians to consider fitness and physical activity in promoting healthy aging.
Abstract O.35: BCGits as a Clinical Diagnosis Marker in Mexican Children with Kawasaki Disease
Authors: Jose A Castillo-Moguel, Mario A Ynga-Duran, Eduardo Galvez-Cuitiva, Cesar Carrasco, Giovanni Sorcia-Ramirez, Luis M Garrido-Garcia
Journal: Circulation (2015)

Background: Kawasaki disease (KD) is an acute febrile illness characterized by systemic vasculitis of unknown etiology. A BCG reactivation (BCGitis) is not included in the classical clinical criteria for KD. BCGitis recently has been recognized as a clinical marker of incomplete KS in younger children in countries where BCG vaccination is mandatory. Objectives: To assess the frequency of BCGitis in the clinical profile of patients diagnosed with KD in a Mexican third level Children’s Hospital and its association with the presence of coronary artery abnormalities. (CAA) Material and Methods: An observational, comparative, retrospective and case control study of all patients diagnosed with KD at our Institution between August 1995 and May 2014 was performed. The clinical presentation, laboratory results, treatment used and coronary artery abnormalities in the BCG-reactive [BCG(+)] and BCG-nonreactive [BCG(-)] groups were analyzed and compared. Results: We included 356 patients with KD diagnosed at our institution; 83 had BCGitis. (23.3%) The BCG(+) group was younger than the BCG(-) group, 21.2 ± 22.51 vs 44.33 ± 38.85 months (p &lt; 0.00001) There were 17 (20.48%) incomplete cases in the BCG(+) group compared with 52 (19.11%) in the BCG(-) group without statistical significance. The BCG(+) group had a slightly shorter fever duration before IVGG treatment than the BCG(-) group. Laboratory results showed lower hemoglobin counts, higher white blood cell counts, platelet counts, CRP counts, and ALT counts in the BCG(+) group. The BCG+ group developed CAA in 29 cases and the BCG- group developed CAA in 110 cases without statistical significance. Multivariate analysis showed that younger age at diagnosis (&lt; 24 months) was the only factor significantly associated with a reaction at the BCG inoculation site in KD patients Conclusions: In Mexico, as a country with a National BCG Vaccination Program and a low incidence of KD, a reaction at the BCG inoculation site could be a useful and early diagnostic sign of KD among younger patients, especially those younger than 24 months of age.
Abstract 19123: Arginine Vasopressin Receptor 1A and Alpha 1A-Adrenergic Receptor Form Heteromeric Complexes on Human Vascular Smooth Muscle Cells
Authors: Lauren J Albee, Heather M LaPorte, Matthias Majetschak
Journal: Circulation (2016)

Introduction:  Alpha  1 -adrenergic receptors (α 1 -AR) and arginine vasopressin receptors (AVPR) are essential for regulating vascular smooth muscle function. Numerous previous observations demonstrated cross-talk between these receptors, but the underlying mechanisms remain poorly understood. Recent evidence suggests formation of heteromeric receptor complexes between G protein-coupled receptors as a possible mechanism for receptor cross-talk.   Hypothesis:  We hypothesize that α 1A -AR and arginine vasopressin receptor 1A (AVPR1A) form heteromeric complexes on human vascular smooth muscle cells (hVSMC).   Methods:  Proximity ligation assays (PLA) were utilized to visualize and quantify individual receptors and receptor-receptor interactions on hVSMC (ATCC PCS-100-012) at single molecule resolution. PLA signals were quantified using the Duolink Image Tool software. Co-immunoprecipitation was used to confirm PLA findings. The selectivity of all antibodies were confirmed with siRNA knockdown of the corresponding receptors. Data are presented as mean ± SEM from n=3 independent experiments with n=10 vision fields analyzed per condition and experiment. Data were analyzed with one-way ANOVA and Dunnett’s post-hoc correction. A 2-tailed p   Results:  The following PLA signals/cell were obtained for the detection of individual receptors: AVPR1A - 1830.01 ± 256.10, α 1A -AR - 65.99 ± 12.85, α 1B -AR - 371.80 ± 57.61, α 1D -AR - 167.90 ± 41.46 (p 1A -AR:AVPR1A - 58.82 ± 8.790, α 1A -AR:α 1B -AR - 48.99 ± 4.85, α 1A -AR:α 1D -AR - 22.40 ± 6.612 and α 1B -AR:α 1D -AR - 33.35 ± 4.850. The number of PLA signals for all receptor interactions except for α 1A -AR:α 1D -AR were significant vs. negative control (omission of minus strand secondary probe in PLA, 1.877 ± 0.449). The interaction between AVPR1A and α 1A -AR could be confirmed in co-immunoprecipitation experiments after AVPR1A pull-down.   Conclusions:  Our observations confirm previous findings from expression systems on heteromeric complexes among α 1 -AR subtypes and suggest that heteromeric complexes between AVPR1A and α 1A -AR are constitutively expressed on native hVSMC.
Abstract 1591: Ivabradine But Not Atenolol Attenuates The Decline In Ejection Fraction And Preserves Coronary Reserve In Post-infarcted Middle-aged Rats
Authors: Robert J Tomanek
Journal: Circulation (2008)

We compared the effects of heart rate reduction (HRR) by the I f  channel inhibitor, ivabradine (MI+IVA) and the β-blocker, atenolol (MI+ATEN) on ventricular remodeling and perfusion after myocardial infarction (MI). MI was induced in 12-mo.-old male Sprague-Dawley rats by left coronary artery ligation. Sham-operated rats (Sham) served as age-matched controls. Rats were treated for 1– 4 weeks and the drug doses were adjusted so that HRR would be comparable in the two groups; mean HRR ± SEM was 19.5 ± 1.1% for MI + IVA and 19.0 ± 0.8% for MI ± ATEN. Infarct areas (% of LV free wall) were not significantly different between groups: MI 64 ± 3; MI ± IVA 56 ± 3; MI ± ATEN 62 ± 3. Coronary reserve (fold increase in conductance during maximal vasodilation in response to dipyridamole), volume to mass ratio and ejection fraction (determined by echocardiograms 4 weeks after ligation) revealed the following values (*, p
Prevalence, characteristics and management of frequently exacerbating asthma patients: an observational study in Sweden (PACEHR)
Authors: Christer Janson, Karin Lisspers, Björn Ställberg, Gunnar Johansson, Marcus Thuresson, Gunilla Telg, Kjell Larsson
Journal: European Respiratory Journal (2018)

The aim of the study was to investigate the prevalence, management and characteristics of asthma patients with frequent exacerbations. Data from asthma patients (aged ≥18 years) identified in primary care medical records were linked to Swedish national health registries. Exacerbations were defined as hospitalisations, emergency visits and/or collection of oral steroids. Frequent exacerbations were defined as two or more exacerbations per year during the 3-year observation period. Of 18 724 asthma patients, 81.49% had no exacerbations and 6.3% had frequent exacerbations in the year prior to the index date. Frequent exacerbations were observed yearly for 1.8% of the patients. Frequent exacerbators were older, more often females, and had increased eosinophil and neutrophil counts, lower lung function, and more comorbidities than patients without exacerbations. There was a slight increase in asthma medication claims and a slight decrease in physician visits compared with baseline, both in the group with and the group without frequent exacerbations. Patients with frequent exacerbations were characterised by greater age, female predominance, high eosinophil and neutrophil counts, and high prevalence of comorbidities. This study indicates that the Swedish healthcare system lacks efficiency to adjust treatment and management for this patient group. With new treatment options targeting severe asthma available, identification of these patients should be in focus to ensure reduction of exacerbations.
Abstract 15403: Is the Sum Greater Than the Whole? Association of Heart Risk Factors and Echocardiographic Parameters With Reduction in 6-Minute Walk Test in Stage A Heart Failure
Authors: Mark T Nolan, Ying Wang, Hilda Yang, Thomas H Marwick
Journal: Circulation (2015)

Introduction: Chemotherapy increases long-term risk of heart failure (HF), but its impact relative to other HF risk factors is unknown. 6 minute walk test (6MWT) provides prognostic information regarding hospitalization and mortality in HF patients. We sought the relative role of these factors on echocardiographic changes and 6MWT. Hypothesis: Prior chemotherapy is associated with greater functional impairment than other stage A HF risk factors. Methods: We recruited 521 asymptomatic pts from the community aged ¬&gt;65 years with stage A heart failure (SAHF, based on at least one of: diabetes, obesity, hypertension, coronary artery disease or chemotherapy). All went echocardiographic studies and 6MWT. 45 patients had previous chemotherapy (mean interval 7±7.5 years) and underwent 6MWT. These patients were matched 2:1 using demographic and clinical characteristics with patients who did not receive chemotherapy. Fisher’s test and independent t-test were used for statistical analysis. Results: There were no significant difference in demographic variables. The chemotherapy group had a significantly lower 6MWT distance (mean difference -155m) and significantly higher proportion of patients with 6MWT distance &lt; 400m (26.7% vs. 11%, p=0.043). There were no significant difference in other echocardiographic parameters assessing systolic, diastolic and geometrical parameters. Conclusion: Prior chemotherapy has a significant long-term effect on functional capacity in comparison with other SAHF factors. As no one echo parameter was associated with this difference, this could potentially be secondary to noncardiac (including vascular) parameters.