tbuckley/cabot-search huggingface dataset:
Aggravation of mild axillary hidradenitis suppurativa by microwave ablation: Results of a randomized intrapatient–controlled trial
Authors: Allard R.J.V. Vossen, Manon A.P.C. van Huijkelom, Tamar E.C. Nijsten, Eric W.P. Bakker, Hessel H. van der Zee, Martijn B.A. van Doorn, Errol P. Prens
Journal: Journal of the American Academy of Dermatology (2018)
HGG-42. GLIOMA ONCOGENESIS IN CONSTITUTIONNAL MISMATCH REPAIR DEFICIENCY (CMMRD) SYNDROME: A CLINICO-PATHOLOGICAL AND MOLECULAR STUDY IN 15 PATIENTS
Authors: Jane Merlevede, Felipe Andreiuolo, Marie-Anne Debily, Lea Guerrini-Rousseau, Stephanie Picot, Emilie Barret, Noémie Lavoine, David Castel, Stephanie Puget, Laurence Brugieres, Pascale Varlet, Jacques Grill
Journal: Neuro-Oncology (2018)

Glioma are frequently seen in the second decade of life in children with constitutional mismatch repair deficiency (CMMRD) syndrome. They are often associated with a high mutation load but their characteristics have not been extensively described. Your study describes 15 cases including 2 siblings from the radiological, histological et molecular (Whole Exome Sequencing) points of view. Tumors were frequently associated with lesions of different ages (multicentric) or vascular malformations. Different histologies were observed with a majority of glioblastomas (n=9) and giant tumor cells were almost always present. Immunohistochemistry was positive for p53 in 14/15 (concordant with mutations detected with sequencing) and was negative for ATRX in 11/15 (concordant with mutations detected with sequencing in all but one patient). PDL1 expression was only seen in 6/15. Mutation load was above 100/Mb in all but four; all hypermutated tumors had secondary mutations in POLE or POLD1. PMS2 and MSH2 were the two most frequently MMR genes mutated. The distribution of the variant allele frequency was most frequently bi- or tri-modal suggesting different waves of mutations gains. SomaticSignatures and DeconstructSig identified various combinations of signatures in the different exomes. Qualitatively mutations observed in the CMMRD samples were different from those observed in common pediatric high-grade gliomas (pHGG): absence of K27M and G34R/V mutations in H3F3A, absence of BRAF V600E mutation, absence of IDH1 R132H mutation, TP53 mutations were present in all but one. In conclusion, CMMRD-associated gliomas represent a distinct entity of pHGG with a specific oncogenesis.
Abstract 11366: Retained Cardiac Implantable Electronic Device Fragments After Incomplete Extraction Do Not Adversely Affect Magnetic Resonance Imaging Quality or Safety
Authors: Christopher Austin, Kevin Landolfo, Pragnesh Parikh, Fred Kusumoto
Journal: Circulation (2016)

Introduction: The prevalence of cardiac implantable electronic devices (CIED) is steadily increasing. Accordingly, the frequency of CIED extraction has also increased. Occasionally, safe retrieval of all CIED components is not feasabile and lead fragments are left behind. Little is known about the safety and diagnostic accuracy of MRI in patients with retained CIED fragments. Methods: Two hundred consecutive patients were identified as having undergone orthotopic heart transplantation (OHT) at our institution between April 2006 and December 2014. Chest x-rays immediately prior to OHT were reviewed for presence of CIED and chest x-rays immediately following OHT were reviewed for retained CIED fragments. MRI performed after OHT in patients with retained CIED fragments were inspected for image quality and procedural safety. The most recent chest x-ray in patients with retained CIED fragments subjected to MRI was reviewed for change in fragment position. Results: One hundred seventy-eight of 200 patients (89%) had CIED prior to OHT. All patients with CIED had surgical device extraction at the time of OHT. Of these, 29 patients (12%) had retained CIED fragments after OHT, the majority of which (23/29) were ICD coil fragments located in the superior vena cava, brachiocephalic or subclavian vein. Ten patients with retained CIED fragments underwent a total of 28 MRI after OHT. No patient safety issues were identified during MRI acquisition, and all MRI images were of diagnostic quality. There were no changes in the position of CIED fragments following MRI. Conclusions: Diagnostic MRI can be safely performed in patients with retained CIED fragments after incomplete device extraction. Adherence of the ICD coil to the vessel wall due to fibrosis has been well described and is a common impediment to complete device extraction. Retrieval of these fragments prior to MRI does not appear warranted given the demonstrated safety and preserved MRI image quality in this population.
Protecting Infants From Sleep-Related Deaths
Authors: Kyran P. Quinlan, Douglas R. Roehler, Jean Silvestri
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
The potential value of crowdsourced surveillance systems in supplementing sentinel influenza networks: the case of France
Authors: Caroline Guerrisi, Clément Turbelin, Cécile Souty, Chiara Poletto, Thierry Blanchon, Thomas Hanslik, Isabelle Bonmarin, Daniel Levy-Bruhl, Vittoria Colizza
Journal: Eurosurveillance (2018)

Introduction Participatory surveillance systems provide rich crowdsourced data, profiling individuals and their health status at a given time. We explored the usefulness of data from GrippeNet.fr, a participatory surveillance system, to estimate influenza-related illness incidence in France. Methods: GrippeNet.fr is an online cohort since 2012 averaging ca. 5,000 weekly participants reporting signs/symptoms suggestive of influenza. GrippeNet.fr has flexible criteria to define influenza-related illness. Different case definitions based on reported signs/symptoms and inclusions of criteria accounting for individuals’ reporting and participation were used to produce influenza-related illness incidence estimates, which were compared to those from sentinel networks. We focused on the 2012/13 and 2013/14 seasons when two sentinel networks, monitoring influenza-like-illness (ILI) and acute respiratory infections (ARI) existed in France. Results : GrippeNet.fr incidence estimates agreed well with official temporal trends, with a higher accuracy for ARI than ILI. The influenza epidemic peak was often anticipated by one week, despite irregular participation of individuals. The European Centre for Disease Prevention and Control ILI definition, commonly used by participatory surveillance in Europe, performed better in tracking ARI than ILI when applied to GrippeNet.fr data. Conclusion : Evaluation of the epidemic intensity from crowdsourced data requires epidemic and intensity threshold estimations from several consecutive seasons. The study provides a standardised analytical framework for crowdsourced surveillance showing high sensitivity in detecting influenza-related changes in the population. It contributes to improve the comparability of epidemics across seasons and with sentinel systems. In France, GrippeNet.fr may supplement the ILI sentinel network after ARI surveillance discontinuation in 2014.
Failure of Classical β-Blocker Carvedilol to Deactivate Brown Adipose Tissue in a Patient With Pheochromocytoma
Authors: Ioannis Tsechelidis, Eva El Darazi, Raoul Muteganya, Kathleen Weyts, Serge Goldman
Journal: Clinical Nuclear Medicine (2018)

Abstract A 37-year-old woman with pheochromocytoma underwent presurgical FDG PET/CT. Despite her usual antiadrenergic medication consisting in 25 mg of carvedilol, PET/CT demonstrated intense and widespread FDG uptake in brown adipose tissue (BAT). No BAT FDG uptake was detectable on a repeated examination after specific preparation consisting in 40 mg propranolol and 5 mg diazepam. We therefore recommend this propranolol-diazepam preparation in patients with pheochromocytoma referred for PET/CT. Carvedilol—classically prescribed to alleviate effects of adrenergic overstimulation—seems ineffective on BAT. This observation questions the benefit of carvedilol to reduce β3-adrenoreceptor–mediated effects, not only in BAT, but also in other tissues.
EPID-05. EARLY DIAGNOSIS OF CHILDHOOD BRAIN TUMOURS: HELPING FAMILY CLINICIANS TO BE MORE ‘HEADSMART’
Authors: Shaarna Shanmugavadivel, Rebecca Chellaswamy, Jo-Fen Liu, David Walker
Journal: Neuro-Oncology (2018)

The HeadSmart campaign has been associated with reducing median total diagnostic interval of childhood brain tumours in UK from 14.4 weeks to 6.5 weeks with a new aim of 4 weeks. In 2013, only 26% of family clinicians were aware of the campaign. We conducted a year-long project in collaboration with Royal College of General Practitioners (RCGP) aiming to enhance awareness amongst this crucial professional group. Two surveys were conducted collecting data on confidence, knowledge and awareness. An online toolkit was launched on the RCGP website and two interactive face-to-face courses took place. Descriptive statistics were used for analysis of data. 142 and 71 GPs completed the pre and post survey respectively. Awareness of national guidance increased from 28% to 52% (p<0.001). GPs self-rated level of confidence in recognising signs/symptoms increased from 4.8 to 5.7 on a scale of 1-10. The toolkit received 1196 hits in the first week with average time spent as 5 minutes and 45 seconds, making it one of the most successful RCGP Toolkit launches. 80 GPs attended 2 workshops. 100% of participants reported improved confidence in ability to recognise signs/symptoms and 87% said they ‘would’/‘definitely would’ use the toolkit in their own practice. Free text included “Excellent & informative”, “sharing this with my team” and “this is the best course I have attended in some years”. Awareness, knowledge and confidence of important diagnoses amongst professional groups can be enhanced significantly by focusing education through their professional bodies.
Gynaecologist who asked patient about sex toys and pornography is struck off
Authors: Clare Dyer
Journal: BMJ (2018)

An associate specialist in obstetrics and gynaecology has been struck off, after a medical practitioners tribunal found that he performed a vaginal inspection without informed consent, asked the patient if it made her want to have sex, and offered to install pornography on her computer.

Iftekhar Ahmed later called the woman at home to again suggest that he come over and install pornography on her computer, the tribunal found.

Ahmed had two genitourinary medicine consultations at Princess Royal Community Health Centre in Huddersfield, West Yorkshire, in 2013 and 2015 with the woman, named only as “Patient A.” Her diagnosis was vulvovaginitis.

He was also found …
Health Data and Privacy in the Digital Era
Authors: Lawrence O. Gostin, Sam F. Halabi, Kumanan Wilson
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIPG-20. PRE-RANDOMISATION CENTRAL REVIEW AND REAL-TIME BIOMARKERS SCREENING IN THE MULTICENTRE BIOLOGICAL MEDICINE FOR DIPG ERADICATION (BIOMEDE) TRIAL: LESSONS LEARNT FROM THE FIRST 120 BIOPSIES
Authors: Pascale Varlet, Marie-Anne Debily, Gwenael Le Teuff, Arnault Tauziede-Espariat, Mélanie Pages, Felipe Andreiuolo, Emanuele Lechapt-Zalcman, Emilie Barret, Stephanie Picot, Karsten Nysom, Sophie Pravong, Gilles Vassal, David Castel, Stephanie Puget, Jacques Grill
Journal: Neuro-Oncology (2018)

BIOMEDE is a multicentre, phase-II trial comparing efficacy of erlotinib, everolimus, and dasatinib in combination with radiotherapy, in newly diagnosed diffuse intrinsic pontine glioma (DIPG) (NCT02233049). Randomisation is based on biomarkers determined in upfront stereotactic biopsies: mTOR pathway activation detected by the loss of PTEN expression and EGFR overexpression. A central pathology review is mandatory in BIOMEDE for DIPG diagnosis confirmation, assessment of H3K27M immunostatus, PDGFRA amplification by FISH and biomarkers evaluation for treatment allocation (no erlotinib if no EGFR overexpression; no everolimus if no PTEN loss, no specific marker for dasatinib allocation). We evaluated the process feasibility and the agreement between H3.3 immunoprofil and genotyping on the first 120 patients. DIPG was centrally confirmed in 94% of cases (median time=1 day; range 0–6). The differential diagnoses were HGNET-MYCN (n=1) and angiocentric glioma MYB-QKI (n=1). No tumoral infiltration was found in 3 cases and extensive necrosis in 1 case. Overall, 38/118 evaluable cases showed EGFR overexpression (32%) and 90/118 had PTEN loss (76%). 15/105 evaluable cases had PDGFRA amplification (14%). Trimethylation loss at H3K27 was detected in all samples but 4 corresponding to HGNET-MYCN, angiocentric glioma and to 2 H3 wild-type gliomas. Agreement between genotyping (H3.3 and/or H3.1) and H3K27M immunostatus (loss of trimethylation and/or H3K27M) is substantial (Kappa coefficient=0.79, 95%-confidence interval, 0.41 to 1). These data document the feasibility of real-time molecular pathology and biomarkers screening in international multicentre trials.
DIPG-60. PPM1D MUTATION MEDIATES TUMORIGENESIS AND IS A THERAPEUTIC TARGET IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
Authors: Mwangala Akamandisa, Kai Nie, Jing Wen, Rita Nahta, Dolores Hambardzumyan, Robert Castellino
Journal: Neuro-Oncology (2018)
Correlation of neutrophil lymphocyte ratio, platelet lymphocyte ratio and rate of change of CA 19.9 in predicting outcome for metastatic pancreatic cancer
Authors: A. Dean, D. Higgs, A. Das, M. Rogers-Seeley, S. Fennessy, C. McGarvey, M. McNulty
Journal: Annals of Oncology (2018)

Introduction: CA19.9, NLR and PLR have all been proposed as prognostic in pancreatic cancer. We analysed correlation between NLR, PLR and rate of change of CA19.9. Methods: A total of 63 metastatic pancreatic cancer patients were identified from our database and evaluated retrospectively for blood count, NLR, PLR and serial CA19.9 levels during treatment. Daily Rate of Change of CA19.9 levels were calculated for the first 90 days (DRC90) of the patient's treatment. Kaplan Meir curves, univariate and multivariate Cox regression analyses were calculated to assess the effects of these 3 markers on overall survival. Results: In a univariate analysis, PLR > 240, NLR > 5 and DRC90 > 0.4% were all significantly associated with deceased overall survival. The Cox proportional hazards model showed that NLR < 5 (HR 0.475, 95% CI 0.259 to 0.873, P = 0.017), PLR < 240 (HR 0.444, 95% CI 0.229 to 0.861, P = 0.016), and a DRC90 < 0.4% (HR 0.294, 95% CI 0.102 to 0.851, P = 0.024) were independent predictors of good prognosis (22.6 months vs. 9.6 months, 22.3 months vs 12.4 months and 23.9 months vs. 9.3 months respectively). In multivariate analysis, only a DRC90 < 0.4% was independently associated with a longer survival (HR 0.239, 95% CI 0.076 to 0.752, P = 0.014). The formula (F) {PLR + (NLRxNLR) + (DRC90 x 100)} was predictive for survival, as patients with F > 190 (HR 3.295, 95% CI 1.232 to 8.807, P = 0.017), having a significantly lower survival rate than patients with F < 190 (25.1 months vs. 10.6 months, logrank P = 0.009). Conclusion: These findings indicate the prognostic utility of the rate of CA 19.9 decline measured as a standardised daily percentage change in value over 90 days. Our data validates daily rate of change of CA 19.9 over 90 days as an independent variable that correlates with prognosis, independent of PLR and NLR. We also identified a novel formula PLR + (NLRxNLR) + (DRC90 x 100) as being predictive for survival. We would like to increase the sample size to further validate our initial findings and investigate possible relationships in combining these variables for better prognostication in metastatic pancreatic cancer.
Post-operative venous thromboembolism increased mortality in patients with either adenocarcinoma or non-adenocarcinoma pancreatic cancer
Authors: K. Majmudar, L. Diaz Quintero, H. Fuentes, S. Stocker, A. Tafur, M. Talamonti
Journal: Annals of Oncology (2018)

Introduction: Pancreatic Cancer is strongly associated with thrombosis and early thrombosis in adenocarcinoma patients has an independent impact on mortality. It is not known whether timing of post-operative thrombosis in pancreatic cancer surgery is an independent predictor of mortality in adenocarcinoma (ACPC) or non-adenocarcinoma pancreatic cancer (NACPC) patients. We investigated post-operative VTE mortality among patients with ACPC compared to NACPC. Methods: We analyzed a prospectively collected database of patients who underwent pancreatic cancer-related surgery with either palliative or curative purposes from 2007 to 2016. Diagnosis of pancreatic malignancy was confirmed by histology. The surgical procedures performed include standard Whipple, pyloric-preserving modified Whipple, exploratory laparotomy, open or laparoscopic distal pancreatectomy with or without splenectomy and total pancreatectomy. Patients were guideline compliant with post-operative prophylaxis. All VTE events were confirmed by imaging. We selected patients with NACPC and a random sample of patients with ACPC. Post-operative VTE (PVTE) was defined as VTE occurring within 3 months of surgical intervention. Mortality was determined by patient follow-up and combined with review of the Social Security Death Index. Statistical analysis for the main outcome was performed using Cox Proportional Hazards Regression using IBM SPSS. Results: 441 pancreatic cancer surgery patients were included. 331 had ACPC and 110 had NACPC, including 46 (41.8%) IPMN and 17 (15.4%) neuroendocrine tumors. Median follow up was 449 days during which 90 (20.4%) patients developed VTE. PVTE occurred in 53 (12.0%) patients, including 41 (12.4%) ACPC patients and 12 (10.9%) NACPC patients. Those with PVTE had 60% higher mortality rate. A multivariable analysis including cancer type, patient age >75 years old, Whipple technique, surgical time, gender and presence of metastatic disease found that PVTE is an independent predictor of increased mortality [HR Adj 1.6 (1.1 - 2.2), p;0.01)]. The mortality impact was not consistent between the ACPC [HR 3.2 (1.3; 7.9)] and NACPC groups [HR 1.3 (0.9; 1.8), p= NA]. Conclusion: Post-operative venous thromboembolism is an independent predictor of increased mortality in pancreatic cancer including those with non-adenocarcinoma pancreatic cancer.
Homeobox Gene Duplication and Divergence in Arachnids
Authors: Daniel J Leite, Luís Baudouin-Gonzalez, Sawa Iwasaki-Yokozawa, Jesus Lozano-Fernandez, Natascha Turetzek, Yasuko Akiyama-Oda, Nikola-Michael Prpic, Davide Pisani, Hiroki Oda, Prashant P Sharma, Alistair P McGregor
Journal: Molecular Biology and Evolution (2018)

Homeobox genes are key toolkit genes that regulate the development of metazoans and changes in their regulation and copy number have contributed to the evolution of phenotypic diversity. We recently identified a whole genome duplication (WGD) event that occurred in an ancestor of spiders and scorpions (Arachnopulmonata), and that many homeobox genes, including two Hox clusters, appear to have been retained in arachnopulmonates. To better understand the consequences of this ancient WGD and the evolution of arachnid homeobox genes, we have characterized and compared the homeobox repertoires in a range of arachnids. We found that many families and clusters of these genes are duplicated in all studied arachnopulmonates (Parasteatoda tepidariorum, Pholcus phalangioides, Centruroides sculpturatus, and Mesobuthus martensii) compared with nonarachnopulmonate arachnids (Phalangium opilio, Neobisium carcinoides, Hesperochernes sp., and Ixodes scapularis). To assess divergence in the roles of homeobox ohnologs, we analyzed the expression of P. tepidariorum homeobox genes during embryogenesis and found pervasive changes in the level and timing of their expression. Furthermore, we compared the spatial expression of a subset of P. tepidariorum ohnologs with their single copy orthologs in P. opilio embryos. We found evidence for likely subfunctionlization and neofunctionalization of these genes in the spider. Overall our results show a high level of retention of homeobox genes in spiders and scorpions post-WGD, which is likely to have made a major contribution to their developmental evolution and diversification through pervasive subfunctionlization and neofunctionalization, and paralleling the outcomes of WGD in vertebrates.