tbuckley/cabot-search huggingface dataset:
Clinical outcome of immune related hepatitis (IrHep) in patients with advanced melanoma (AM) treated with single agent or combination immune checkpoint inhibitors (ICIs)
Authors: N. Shah, J. Puthiamadathil, M.T. Serzan, A. Belouali, W.J. Kelly, B. MA, M. blackburn, A. Knoedler, S. OchoaGonzaelz, M. Janni, S. Madhavan, G.T. Gibney, M.B. Atkins
Journal: Annals of Oncology (2018)
Abstract P045: The Association Between Cigarette Smoking and Cardiovascular Inflammation: The Genetic Epidemiology Network of Arteriopathy Study
Authors: Martin Tibuakuu, Daisuke Kamimura, Sina Kianoush, Andrew DeFilippis, Mahmoud Al Rifai, Kenneth R Butler, Thomas H Mosley, Michael E Hall, Michael J Blaha
Journal: Circulation (2017)

Background: To assist in the regulation of novel and existing tobacco products, there is a need to identify biomarkers of early cardiovascular damage following tobacco exposure. Our prior work suggests that inflammatory markers, in particular high-sensitivity C-reactive protein (hsCRP), may be sensitive markers of tobacco mediated cardiovascular damage. We aimed to further study the association of smoking and inflammation in a cohort with hsCRP and 11 other measures of inflammation associated with cardiovascular disease (CVD) risk. Methods: We conducted a cross-sectional analysis on 2,550 siblings diagnosed with essential hypertension prior to age 60 years. Cigarette smoking was assessed by status, intensity, pack-years, and time since quitting. We modeled each biomarker per standard deviation after natural log transformation and evaluated the association between smoking and biomarkers using generalized estimating equations (GEE) to account for intra-familial correlations. Models were adjusted for demographics and CVD risk factors. Results: The mean age of participants was 61±10 years; 64.5% were women and 54.4% African American. There were 12.2% current smokers and 32.2% former smokers. Compared to never smokers, current smokers had significantly higher levels of 8 inflammatory biomarkers ( Table ). In analyses of other smoking variables, there was a consistent association with hsCRP but not other biomarkers. HsCRP was positively associated with pack-years of cigarette smoked and inversely associated with time since quitting, but not with smoking intensity. There was a significant difference in hsCRP levels among current smokers by race ( p for interaction=0.005). On average, hsCRP was higher among African American [0.445 (0.283, 0.606)] compared to White smokers [0.183 (0.011, 0.356)]. Conclusion: Biomarkers of inflammation, especially hsCRP, may allow for early detection of cardiovascular injury due to cigarette smoking and could be useful for the study and regulation of emerging tobacco products.
Abstract 11661: Novel Phytopeptide Osmotin Mimics Atheroprotective Effects of Adiponectin via AdipoR1
Authors: Yui Takahashi, Rena Watanabe, Yuki Sato, Nana Ozawa, Remina Shirai, Kengo Sato, Takuya Watanabe
Journal: Circulation (2017)

Introduction: A novel phytohormone osmotin has been recently reported to act like the mammalian adiponectin possibly through PHO36/AdipoR1 in various in vitro and in vivo models. However, there hav...
Concurrent cisplatin and dose escalation with intensity-modulated radiotherapy (IMRT) versus conventional chemo-radiotherapy for locally advanced (LA) head and neck squamous cell carcinomas (HNSCC): GORTEC 2004-01 randomized phase III trial
Authors: Y. Tao, A. Auperin, P. Blanchard, M. Alfonsi, X.-S. Sun, M. Rives, Y. Pointreau, J. Castelli, P. Graff, S. Wong Hee Kam, J. Thariat, O. Veresezan, A. Cornely, O. Casiraghi, M. Lapeyre, J. Bourhis
Journal: Annals of Oncology (2018)
Response to: ‘Chronic hydroxychloroquine/chloroquine exposure for connective tissue diseases and risk of Alzheimer’s disease’ by Lee
Authors: Laurence Fardet, Irene Petersen, Irwin Nazareth
Journal: Annals of the Rheumatic Diseases (2018)

We agree with Lee1 that observational studies are limited by unmeasured and unknown confounding which can be best handled by a sufficiently powered randomised controlled trial. As mentioned in the discussion of our paper, we also acknowledge that Chou et al in their research on the Taiwanese National Health Insurance Research Database …
A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex
Authors: Sarah J. Marzi, Szi Kay Leung, Teodora Ribarska, Eilis Hannon, Adam R. Smith, Ehsan Pishva, Jeremie Poschmann, Karen Moore, Claire Troakes, Safa Al-Sarraj, Stephan Beck, Stuart Newman, Katie Lunnon, Leonard C. Schalkwyk, Jonathan Mill
Journal: Nature Neuroscience (2018)
Pilot study: Nurses' role in management of cutaneous toxicity in patients with targeted therapies anti EGFR-Is' treatment
Authors: O. Diamanti, T.M. Zacheo, C. Lando, C. Magro, G. Pauletti, E. Zemella, C. Fano, F. Bonadies, E. Sarno, A. Venturi, P. De Vecchi, S. Menuzzo, S. Gallimberti, D. Grosso
Journal: Annals of Oncology (2018)
Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica
Authors: Kelvin Robertson, Laurence A. G. Marshman, David Plummer, Elena Downs
Journal: JAMA Neurology (2018)

Optimal pharmacologic treatment for chronic sciatica (CS) is currently unclear. While gabapentin (GBP) and pregabalin (PGB) are both used to treat CS, equipoise exists. Nevertheless, pharmaceutical regulation authorities typically subsidize one drug over the other. This hinders interchange wherever the favored drug is either ineffective or ill-tolerated.To assess GBP vs PGB head to head for the treatment of CS.A preplanned interim analysis of a randomized, double-blind, double-dummy crossover trial of PGB vs GBP for management of CS at half the estimated final sample size was performed in a single-center, tertiary referral public hospital. A total of 20 patients underwent randomization from March 2016 to March 2018, and 2 were excluded with 1 lost to follow-up and the other requiring urgent surgery unrelated to the study. Patients attending a specialist neurosurgery clinic with unilateral CS were considered for trial recruitment. Chronic sciatica was defined as pain lasting for at least 3 months radiating into 1 leg only to, at, or below the knee level. Imaging (magnetic resonance imaging with or without computed tomography) corroborating a root-level lesion concordant with symptoms and/or signs was determined by the trial clinician. Inclusion criteria included patients who had not used GBP and PGB and were 18 years or older. Analyses were intention to treat and began February 2018.Randomly assigned participants received GBP (400 mg to 800 mg 3 times a day) then PGB (150 mg to 300 mg twice daily) or vice versa, each taken for 8 weeks. Crossover followed a 1-week washout.The primary outcome was pain intensity (10-point visual analog scale) at baseline and 8 weeks. Secondary outcomes included disability (using the Oswestry Disability Index) and severity/frequency of adverse events.The total trial population (N = 18) consisted mostly of men (11 [61%]) with a mean (SD) age of 57 (16.5) years. A third of the cohort were smokers (5 [28%]), and more than half consumed alcohol (12 [67%]). Gabapentin was superior to PGB, with fewer and less severe adverse events. Both GBP (mean [SD], 7.54 [1.39] to 5.82 [1.72]; P < .001) and PGB (mean [SD], 7.33 [1.30] to 6.38 [1.88]; P = .002) displayed significant visual analog pain intensity scale reduction and Oswestry Disability Index reduction (mean [SD], 59.22 [16.88] to 48.54 [15.52]; P < .001 for both). Head to head, GBP showed superior visual analog pain intensity scale reduction (mean [SD], GBP: 1.72 [1.17] vs PGB: 0.94 [1.09]; P = .035) irrespective of sequence order; however, Oswestry Disability Index reduction was unchanged. Adverse events for PGB were more frequent (PGB, 31 [81%] vs GBP, 7 [19%]; P = .002) especially when PGB was taken first.Pregabalin and GBP were both significantly efficacious. However, GBP was superior with fewer and less severe adverse events. Gabapentin should be commenced before PGB to permit optimal crossover of medicines.anzctr.org.au Identifier: ACTRN12613000559718.
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
Authors: Qianghu Wang, Baoli Hu, Xin Hu, Hoon Kim, Massimo Squatrito, Lisa Scarpace, Ana C. deCarvalho, Sali Lyu, Pengping Li, Yan Li, Floris Barthel, Hee Jin Cho, Yu-Hsi Lin, Nikunj Satani, Emmanuel Martinez-Ledesma, Siyuan Zheng, Edward Chang, Charles-Etienne Gabriel Sauvé, Adriana Olar, Zheng D. Lan, Gaetano Finocchiaro, Joanna J. Phillips, Mitchel S. Berger, Konrad R. Gabrusiewicz, Guocan Wang, Eskil Eskilsson, Jian Hu, Tom Mikkelsen, Ronald A. DePinho, Florian Muller, Amy B. Heimberger, Erik P. Sulman, Do-Hyun Nam, Roel G.W. Verhaak
Journal: Cancer Cell (2018)
Supratotal resection in glioma: a systematic review
Authors: Charles N de Leeuw, Michael A Vogelbaum
Journal: Neuro-Oncology (2018)

Emerging evidence suggests survival benefit from resection beyond all MRI abnormalities present on T1-enhanced and T2‒fluid attenuated inversion recovery (FLAIR) modalities in glioma (supratotal resection); however, the quality of evidence is unclear. We addressed this question via systematic review of the literature.EMBASE, MEDLINE, Scopus, and Web of Science databases were queried. Case studies, reviews or editorials, non-English, abstract-only, brain metastases, and descriptive works were excluded. All others were included.Three hundred and nine unique references yielded 41 studies for full-text review, with 7 included in the final analysis. Studies were mostly of Oxford Center for Evidence-Based Medicine Level 4 quality. A total of 88 patients underwent supratotal resection in a combined cohort of 492 patients (214 males and 278 females, age 18 to 82 years). Fifty-one supratotal resections were conducted on high-grade gliomas, and 37 on low-grade gliomas. Karnofsky performance status, overall survival, progression-free survival, neurological deficits postoperatively, and anaplastic transformation were the main measured outcomes. No randomized controlled trials were identified. Preliminary low-quality support was found for supratotal resection in increasing overall survival and progression-free survival for both low-grade and high-grade glioma.The literature suggests insufficient evidence for carte blanche application of supratotal resection, particularly in lower-grade gliomas where neurological deficits can result in long-term disability. While the preliminary studies discussed here, containing data from only a few centers, have reported increased progression-free and overall survival, these claims require validation in prospective research studies involving larger patient populations with clearly defined appropriate outcome metrics in order to reduce potential bias.
Pathogenesis, clinical evolution and outcomes of patients with immune checkpoint inhibitor induced acute liver injury: A multicentre study
Authors: L. Au, R. Nathwani, L. Possamai, C. Barlow, T. Tillett, R. Bowen, L. Spain, J. Thomas, M. Backhouse, A. Gurung, R. Morrison, T. Cross, C. Herbert, R. Goldin, M.E. Gore, J. Larkin, C. Antoniades, S. Turajlic
Journal: Annals of Oncology (2018)
A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression
Authors: Xin Chen, Siyi Wanggou, Ankur Bodalia, Min Zhu, Weifan Dong, Jerry J. Fan, Wen Chi Yin, Hyun-Kee Min, Malini Hu, Diana Draghici, Wenkun Dou, Feng Li, Fiona J. Coutinho, Heather Whetstone, Michelle M. Kushida, Peter B. Dirks, Yuanquan Song, Chi-chung Hui, Yu Sun, Lu-Yang Wang, Xuejun Li, Xi Huang
Journal: Neuron (2018)
Immune response, safety, and overall survival of NY-ESO-1+ soft tissue sarcoma patients treated with CMB305 therapy
Authors: S.P. Chawla, S. Pollack, M. Block, M. Druta, K. Do, J.C. Morris, J.W. Kim, C. Bohac, H. Lu, S. Gnjatic, R.L. Jones, P. Hwu, N. Somaiah
Journal: Annals of Oncology (2018)
Abstract 17770: Prognostic Values of Diuretic Response Within 6 Hours From Emergency Department Arrival in Patients With Acute Heart Failure: Insights From REALITY-AHF
Authors: Shunsuke Kuroda, Yuya Matsue, Takahiro Okumura, Keisuke Kida, Shogo Oishi, Eiichi Akiyama, Satoshi Suzuki, Masayoshi Yamamoto, Kazuki Yoshida, Takeshi Kitai, Kenji Yoshioka, Akira Mizukami, Akihiko Matsumura
Journal: Circulation (2017)

Background: Diuretic response (DR) in patients with acute heart failure (AHF) has been shown to be a prognostic predictor. However, prognostic implication of DR measured in emergency department (ED...
Notes from the Field: Exported Case of Sin Nombre Hantavirus Pulmonary Syndrome — Israel, 2017
Authors: Aaron Kofman, Galia Rahav, Del Yazzie, Herman Shorty, Hayley D. Yaglom, Dallin Peterson, Melissa Peek-Bullock, Mary J. Choi, Anat Wieder-Finesod, John D. Klena, Heather Venkat, Cheng-Feng Chiang, Barbara Knust, Marlene Gaither, Matthew Maurer, Donald R. Hoeschele, Stuart T. Nichol
Journal: MMWR Morbidity and Mortality Weekly Report (2018)

In November 2017, CDC confirmed Sin Nombre virus (SNV) infection in a previously healthy man aged 47 years who was admitted to a hospital in Israel after returning from a trip to the western United States. SNV is a species of hantavirus transmitted to humans primarily through contact with the infected urine or droppings of a deer mouse (Peromyscus maniculatus), i
Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial
Authors: Pui Kuan Cheong, Alexander C Ford, Cynthia K Y Cheung, Jessica Y L Ching, Yawen Chan, Joseph J Y Sung, Francis K L Chan, Justin C Y Wu
Journal: The Lancet. Gastroenterology & hepatology (2018)
GW29-e2015 Primary endpoint Outcomes of A Prospective, Single-Blinded, Multi-Center, Randomized, Controlled, Clinical Trial on the Efficacy and Safety of Sirolimus-Eluting Stent (MiStent® System) compared to TIVOLI in the Treatment of Patients with Coronary Heart Disease
Authors: Yaling Han, Zhiyong Wang, Hanjun Pei, Li Zhang, Yuejin Yang, Bo Xu, Yang Zheng, Zheng Zhang, Xinqun Hu, Ziwen Ren, Feng Zheng, None Zhiming Yang, Renqiang Yang, Changqian Wang, Yuexi Wang, Guosheng Fu, Yu Cao, Zuyi Yuan, Bin Wang, Quanmin Jing
Journal: Journal of the American College of Cardiology (2018)
Abstract 17165: Factors Associated With Heart failure Family Caregiver Sleep Quality
Authors: Udia-Oghenetega Otuguor, Melinda K Higgins, Sandra B Dunbar
Journal: Circulation (2016)

Introduction: Caring for persons with heart failure (HF) is demanding and stressful, and may affect sleep quality of family caregivers (FCGs). Although FGCs report sleep disturbances, little is known about factors associated with sleep quality of FCGs of persons with HF. The purpose of this study was to examine the sleep quality of FCGs of persons with HF and associated sociodemographic, clinical and FCG stress factors. Methods: Baseline data from a family caregiver intervention study were used. Participants were FCGs of persons with HF (N=127, mean age 55.3 ± 1.5years, 92% women, 58% African American).Variables measured were self-reported overall sleep quality (PSQI), sociodemographics (age, gender, race, relationship with care recipient), co morbidity (Charlson Comorbidity Index), caregiver stress (Perceived Stress Scale), physical and mental strain (Caregiver Strain Index), life changes resulting from caregiving (Bakas Caregiving Outcome Scale) and caregiving difficulty (Oberst_difficulty & time). Anal...
Phase I/II, first in human trial with M7583, a Bruton’s tyrosine kinase inhibitor (BTKi), in patients with B cell malignancies
Authors: W. Jurczak, S. Rule, W. Townsend, D. Tucker, B. Sarholz, J. Scheele, J. Gribben, P.L. Zinzani
Journal: Annals of Oncology (2018)
Managing long term indwelling urinary catheters
Authors: Catherine Murphy, Alex Cowan, Katherine Moore, Mandy Fader
Journal: BMJ (2018)

### What you need to know Around in 90 000 people in the UK live with a long term catheter (one that has been in place for four weeks or more).1 Use of catheters varies considerably, suggesting differences in how or whether they are used. For example, in a study of more than 4000 people aged over 65 receiving domiciliary care in 11 European countries, long term catheter use ranged from 0% (Netherlands) to 23% (Italy).2 Problems with long term catheters, such as infections or blockage, affect individuals' lives and healthcare resources, particularly out-of-hours services.3 This article aims to help healthcare professionals address the needs of any person living with or making the decision to have a long term indwelling urinary catheter (examples shown in fig 1). Fig 1 Examples of indwelling catheters Urinary retention and urinary incontinence are the two main indications for long term catheters. An algorithm providing an overview of the process for deciding between a long term indwelling catheter and an alternative management options (box 1), is shown in figure 2.45678 Discussion about urinary problems and management options can involve a range of healthcare professionals, including those in primary, community, or secondary care, physicians, and nurses. Box 1 ### Commonly used non-invasive incontinence managementRETURN TO TEXT
Azacitidine with or without eltrombopag for first-line treatment of intermediate- or high-risk MDS with thrombocytopenia
Authors: Michael Dickinson, Honar Cherif, Pierre Fenaux, Moshe Mittelman, Amit Verma, Maria Socorro O. Portella, Paul Burgess, Pedro Marques Ramos, Jeea Choi, Uwe Platzbecker
Journal: Blood (2018)
Abstract 19062: Genome-Wide Association Study of the Human Proteome in a Community-Based Cohort
Authors: Mark D Benson, Qiong Yang, Michelle J Keyes, Deborah Ngo, John O’Sullivan, Dongxiao Shen, Jordan Morningstar, Xu Shi, Laurie Farrell, Sumita Sinha, Ramachandran S Vasan, Thomas J Wang, Robert E Gerszten
Journal: Circulation (2016)

Introduction: Circulating proteins play key roles as markers and effectors of cardiometabolic diseases, though the genetic determinants of relatively few circulating proteins have been defined. We ...
Blockade of NKG2D/NKG2D ligand interaction attenuated cardiac remodelling after myocardial infarction
Authors: Kotaro Matsumoto, Masanori Obana, Arisa Kobayashi, Miho Kihara, Go Shioi, Shigeru Miyagawa, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yoshiki Sawa, Yasushi Fujio
Journal: Cardiovascular Research (2018)

AimsAccumulating evidence demonstrates that cardiomyocyte death contributes to the onset and progression of heart failure (HF) after myocardial injury. Recent studies revealed that immune/inflammatory reactions play important roles in cardiovascular diseases. However, it remains unclear whether immunosurveillance system, which eliminates cytopathic cells, including infected or malignant cancer cells, is involved in cardiomyocyte death, though cardiomyocytes are exposed to pathological stresses during post-infarct remodelling. The aim of this study is to clarify the pathophysiological significance of Natural Killer Group 2 member D (NKG2D)/NKG2D ligand (NKG2DL)-mediated cell death in HF after myocardial infarction (MI).
Phase II trial of neoadjuvant S-1 and concurrent radiotherapy for borderline resectable pancreatic cancer (JASPAC05)
Authors: Izumi Ohno, Shinichiro Takahashi, Tatsushi Kobayashi, Tetsuo Akimoto, Hirochika Toyama, Yasuhiro Shimizu, Soichiro Morinaga, Shoji Nakamori, Shoichi Hishinuma, Norihisa Takakura, Wataru Takayama, Satoshi Hirano, Takehito Otsubo, Masafumi Ikeda, Katsuhiko Uesaka
Journal: Annals of Oncology (2018)
Abstract 14151: Comparing Effectiveness of Quadripolar and Bipolar Left Ventricular Leads in Cardiac Resynchronization Therapy
Authors: Dustin Lee, Christopher Liu, Bruce Lerman, Steve Markowitz, Jim Cheung, James Ip, George Thomas
Journal: Circulation (2016)

Introduction: Cardiac resynchronization therapy (CRT) is an established treatment for patients with heart failure. Quadripolar LV leads create multiple pacing vectors, with potential advantages of reduced pacing thresholds, improved CRT response, less phrenic nerve capture, and less need for LV lead revision. Hypothesis: We assessed the hypothesis that quadripolar leads would be associated with fewer complications and more effective CRT than traditional bipolar LV leads. Methods: In this single-center, retrospective cohort study, 259 consecutive patients receiving a LV pacing lead from 2012-2014 were reviewed. Complications were defined as intra-op (coronary sinus perforation, need to attempt multiple LV leads, inability to place lead) and post-op (need for LV lead or system revision). For complication rates, groups were defined by initial type of LV lead attempted. For effectiveness of CRT, groups were defined by type of LV lead implanted and post-procedure echocardiograms were compared. Results: There w...
New molecular semi-quantification tool provides reliable microbiological evidence for pulmonary infection
Authors: Javier Yugueros-Marcos, Olivier Barraud, Alexandra Iannello, Marie Cécile Ploy, Christine Ginocchio, Margarita Rogatcheva, Cristina Alberti-Segui, Alexandre Pachot, Virginie Moucadel, Bruno François
Journal: Intensive Care Medicine (2018)
Abstract 19365: Hemodynamic Response to Exercise in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients After Upregulation of SERCA2a
Authors: Satyam Sarma, Michinari Hieda, Erin J Howden, Christopher Hearon, Justin Lawley, Sheryl Livingston, Mitchel Samels, Braden Everding, Benjamin D Levine
Journal: Circulation (2017)

Introduction: Impaired ventricular relaxation is a key feature of HFpEF contributing to increased left ventricular (LV) filling pressure during exercise. Sarco/endoplasmic reticulum Ca2+ ATPase (SE...
Oncotype Dx results in patients ≤40 years: Does age matter? New insights
Authors: F. Namuche, R.E. Ruiz, Z.D. Morante Cruz, D. Urrunaga, G. Ziegler, R. Mantilla, M. Leon Rivera, M. Chavez Mac Gregor, H.L. Gomez Moreno
Journal: Annals of Oncology (2018)
A Model for Glomerular Filtration Rate Assessment in Liver Disease (GRAIL) in the Presence of Renal Dysfunction[Link]
Authors: Sumeet K. Asrani, Linda W. Jennings, James F. Trotter, Josh Levitsky, Mitra K. Nadim, W.R. Kim, Stevan A. Gonzalez, Bernard Fischbach, Ranjeeta Bahirwani, Michael Emmett, Goran Klintmalm
Journal: Hepatology (2018)

Estimation of glomerular filtration rate (eGFR) in patients with liver disease is suboptimal in the presence of renal dysfunction. We developed a model for GFR assessment in liver disease (GRAIL) before and after liver transplantation (LT). GRAIL was derived using objective variables (creatinine, blood urea nitrogen, age, gender, race, and albumin) to estimate GFR based on timing of measurement relative to LT and degree of renal dysfunction (www.bswh.md/grail). The measured GFR (mGFR) by iothalamate clearance (n = 12,122, 1985‐2015) at protocol time points before/after LT was used as reference. GRAIL was compared with the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) and Modification of Diet in Renal Disease (MDRD‐4, MDRD‐6) equations for mGFR &lt; 30 mL/min/1.73 m 2 . Prediction of development of chronic kidney disease (mGFR &lt; 20 mL/min/1.73 m 2 , initiation of chronic dialysis) and listing or receipt of kidney transplantation within 5 years was examined in internal cohort (n = 785) and external validation (n = 68,217, 2001‐2015). GRAIL had less bias and was more accurate and precise as compared with CKD‐EPI, MDRD‐4, and MDRD‐6 at time points before/after LT for low GFR. For mGFR &lt; 30 mL/min/1.73 m 2 , the median difference (eGFR–mGFR) was GRAIL: 5.24 (9.65) mL/min/1.73 m 2 as compared with CKD‐EPI: 8.70 (18.24) mL/min/1.73 m 2 , MDRD‐4: 8.82 (17.38) mL/min/1.73 m 2 , and MDRD‐6: 6.53 (14.42) mL/min/1.73 m 2 . Before LT, GRAIL correctly classified 75% as having mGFR &lt; 30 mL/min/1.73 m 2 versus 36.1% (CKD‐EPI), 36.1% (MDRD‐4), and 52.8% (MDRD‐6) ( P &lt; 0.01). An eGFR &lt; 30 mL/min/1.73 m 2 by GRAIL predicted development of CKD (26.9% versus 4.6% CKD‐EPI, 5.9% MDRD‐4, and 10.5% MDRD‐6) in center data and needing kidney after LT (48.3% versus 22.0% CKD‐EPI versus 23.1% MDRD‐4 versus 48.3% MDRD‐6, P &lt; 0.01) in national data within 5 years after LT. Conclusion: GRAIL may serve as an alternative model to estimate GFR among patients with liver disease before and after LT at low GFR.