tbuckley/cabot-search huggingface dataset:
Reply to Matsumoto et al.
Authors: S. Seewald, N. Soehendra
Journal: Endoscopy (2004)

We are grateful for the comments and discussions of Matsumoto et al. with regard to the treatment of isolated fundic varices. There is firm agreement between us that cyanoacrylate is undoubtedly the first-line treatment for acute bleeding from fundic varices. However, we do not agree with the argument of Matsumoto et al. that the rebleeding rates after initial eradication of fundic varices are relatively high [1] [2].
An analysis of which subgroups of multiple myeloma patients, divided according to b(2)-microglobulin and plasma cell labeling index, benefit from high dose vs conventional chemotherapy.
Authors: M. Boccadoro, C Tarella, A Palumbo, C Argentino, S Triolo, A Dominietto, Callea, Vm Lauta, S Molica, P Musto, F Marmont, Am Gianni, A. Pileri
Journal: The Journal of Experimental Medicine (1999)
Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children: a retrospective analysis
Authors: Mary Eapen, Tao Wang, Paul A Veys, Jaap J Boelens, Andrew St Martin, Stephen Spellman, Carmem Sales Bonfim, Colleen Brady, Andrew J Cant, Jean-Hugues Dalle, Stella M Davies, John Freeman, Katherine C Hsu, Katharina Fleischhauer, Chantal Kenzey, Joanne Kurtzberg, Gerard Michel, Paul J Orchard, Annalisa Paviglianiti, Vanderson Rocha, Michael R Veneris, Fernanda Volt, Robert Wynn, Stephanie J Lee, Mary M Horowitz, Eliane Gluckman, Annalisa Ruggeri
Journal: The Lancet Haematology (2017)
Association study of childhood food allergy with genome-wide association studies–discovered loci of atopic dermatitis and eosinophilic esophagitis
Authors: Tomomitsu Hirota, Tsuguhisa Nakayama, Sakura Sato, Noriyuki Yanagida, Teruaki Matsui, Shiro Sugiura, Yuri Takaoka, Nobuyuki Hizawa, Shigeharu Fujieda, Akihiko Miyatake, Takashi Sasaki, Masayuki Amagai, Satoru Doi, Komei Ito, Motohiro Ebisawa, Mayumi Tamari
Journal: Journal of Allergy and Clinical Immunology (2017)
Chronic pulmonary aspergillosis complicating sarcoidosis
Authors: Yurdagül Uzunhan, Hilario Nunes, Florence Jeny, Maxime Lacroix, Sophie Brun, Pierre-Yves Brillet, Emmanuel Martinod, Marie-France Carette, Diane Bouvry, Caroline Charlier, Fanny Lanternier, Carole Planès, Abdellatif Tazi, Olivier Lortholary, Robert P. Baughman, Dominique Valeyre
Journal: European Respiratory Journal (2017)

Chronic pulmonary aspergillosis (CPA) complicating sarcoidosis (SA) is associated with high mortality, and there is a lack of clarity regarding the relative contributions of SA or CPA.This was a retrospective single-centre study on CPA-SA.In total, 65 patients (44 men), aged 41.4±13.5 and 48.3±11.9 years at the time of SA and CPA diagnoses, respectively, were included between 1980 and 2015. Of these, 64 had fibrocystic SA, most often advanced, with composite physiological index (CPI) >40 (65% of patients) and pulmonary hypertension (PH) (31%), and 41 patients (63%) were treated for SA (corticosteroids or immunosuppressive drugs). Chronic cavitary pulmonary aspergillosis (CCPA) was the most frequent CPA pattern. Regarding treatment, 55 patients required long-term antifungals, 14 interventional radiology, 11 resection surgery and two transplantation. Nearly half of the patients (27; 41.5%) died (mean age 55.8 years); 73% of the patients achieved 5-year survival and 61% 10-year survival. Death most often resulted from advanced SA and rarely from haemoptysis. CPI, fibrosis extent and PH predicted survival. Comparison with paired healthy controls without CPA did not show any difference in survival, but a higher percentage of patients had high-risk mould exposure.CPA occurs in advanced pulmonary SA. CPA-SA is associated with high mortality due to the underlying advanced SA rather than to the CPA. CPI, fibrosis extent and PH best predict outcome.
Abstract P245: Increased Hospital Length of Stay as a Predictor of Heart Failure Readmission
Authors: Yao Djilan, Robert G Zoble, Philip Foulis, Adam Zoble, Britta I Neugaard
Journal: Circulation (2012)

Background: Heart Failure (HF) is a major cause of morbidity and mortality with a global prevalence estimated at 16 million. Understanding the risk factors and predictors assists in identifying patients at high risk of subsequent re-hospitalization and death. Consequently, we hypothesized that hospital Length of Stay (LOS) can predict the risk of HF patients’ readmission within a year from an indexed HF hospitalization. Methods: A total of 1,255 HF patients admitted to a VA medical center between January 2004 and December 2009, were identified with IDC-9 code for HF. In order to reduce selection bias, patients were required to have at least on HF readmission from the index HF hospitalization. LOS was categorized in two groups (less than 7 days and more than 7days). The study sample was analyzed using Kaplan Meier (KM) estimate and Cox proportional hazard regression in order to assess the risk of patients’ readmission within a year from their indexed HF hospitalization at a significance level of 0.05. Results: Among the HF patients identified, 511 met the inclusion criteria. The KM curves below show that patients with LOS greater than 7days are more likely to be readmitted compared to those with LOS less than 7 days. Cox proportional hazard regression confirmed this finding with a hazard ratio of 1.39 (CI: 1.08 – 1.79) and a p-value = 0.012 while adjusting for age, tobacco use, diabetes and medications at first HF discharge. Conclusion: From this study sample, we can predict that patients with LOS greater than 7 days are 1.39 times more likely to be readmitted within a year compared to those with LOS less than 7 days.
Who is at Risk for Exhaustion Post-Cardiac Surgery
Authors: Pamela S Miller, Lorraine S Evangelista, Joyce Newman Giger, Teresita Corvera-Tindel, Otoniel Martinez-Maza, Kathleen Dracup, Lynn Doering
Journal: Circulation (2011)

Cjrculatjoo CORE 2. EPIDEMIOLOGY AND PREVENTION OF CV DISEASE: PHYSIOLOGY, PHARMACOLOGY AND LIFESTYLE SESSION TITLE: FATIGUE AND CARDIAC PATIENTS: SICK AND TIRED Abstract 14574: Who is at Risk for Exhaustion Post-Cardiac Surgery Pamela S Miiier, Lorraine S Evangellsta, Joyce Newman Giger, Teresita Corvera-Tinclel, Otonlel Martinez-Maza, Kathleen Dracup and Lynn V Doering Published: November 22, 2011 Artlcle Info & Metrics •Letters ... Jumpto Abstract Background: Vital exhaustion (VE), a psychological state characterized by extreme fatigue, is an independent prognostic indicator of future cardiac events. Despite its prognostic value, little is known about predictors of VE after cardiac surgery. Objective: To investigate socio-demographic and clinical factors associated with risk of postoperative VE following coronary artery bypass graft (CABG) surgery. Methods: In a prospective, cross-sectional pilot study at two cardiac centers, 42 post-CABG patients (age 67.5 ± 12.6 years, 90.5% male) were screened for depression (Patient Health Questionnaire-2) and evaluated for VE (Maastricht Interview) 4 to 8 weeks post-hospitalization discharge. Potential covariates included socio- demographics, clinical characteristics, medical history, cardiovascular risk factors, medications, and preoperative hematology. Stepwise logistic regression analyses were performed to identify predictors of VE. Results: Prevalence rate of VE was approximately 41% (n = 17). Older patients(> 65 years) were less likely to be exhausted (Table; p < 0.05). After adjusting for age, independent predictors of exhaustion were presence of right coronary artery disease (p < 0.05) and higher preoperative left ventricular ejection fraction (LVEF: p < 0.01 ). In a
Prevention of Denervation in Bell's Palsy
Authors: D. Taverner, M. E. Fearnley, F. Kemble, D. W. Miles, O. A. Peiris
Journal: BMJ (1966)

Hyperthyroidism-Williams et al.BRITLSH 391 of these findings to the possible autoimrnmune nature of hyperthyroidism itself is discussed.We are grateful to Dr. Audrey Dawson for the serum vitamin- B12 estimations and to Dr. S. D.
Legal Abortion in Italy, 1978–1980
Journal: New England Journal of Medicine (1983)

In Italy 160532 legally induced abortions were notified in 1991 and 155172 in 1992 (a 34% reduction as against 1982). The abortion rate was 11.0 in 1991 and 10.7 in 1992 while the abortion ratio has been estimated to have declined. Women who sought legal abortion were mainly 25-34 years old married with children. 28% of the abortions in 1992 were obtained by women who had a previous abortion: this value is less than that estimated mathematically (41%). 51% of the abortions were performed within 8 weeks of gestation 87% in hospital 84% by vacuum aspiration 80% under general anaesthesia and 74% without overnight stay. (SUMMARY IN ENG)  (EXCERPT)
Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis
Authors: Cyrielle Caussy, Meera Soni, Jeffrey Cui, Ricki Bettencourt, Nicholas Schork, Chi-Hua Chen, Mahdi Al Ikhwan, Shirin Bassirian, Sandra Cepin, Monica P. Gonzalez, Michel Mendler, Yuko Kono, Irine Vodkin, Kristin Mekeel, Jeffrey Haldorson, Alan Hemming, Barbara Andrews, Joanie Salotti, Lisa Richards, David A. Brenner, Claude B. Sirlin, Rohit Loomba
Journal: Journal of Clinical Investigation (2017)

The risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease and cirrhosis (NAFLD-cirrhosis) is unknown and needs to be systematically quantified. We aimed to prospectively assess the risk of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis.This is a cross-sectional analysis of a prospective cohort of 26 probands with NAFLD-cirrhosis and 39 first-degree relatives. The control population included 69 community-dwelling twin, sib-sib, or parent-offspring pairs (n = 138), comprising 69 individuals randomly ascertained to be without evidence of NAFLD and 69 of their first-degree relatives. The primary outcome was presence of advanced fibrosis (stage 3 or 4 fibrosis). NAFLD was assessed clinically and quantified by MRI proton density fat fraction (MRI-PDFF). Advanced fibrosis was diagnosed by liver stiffness greater than 3.63 kPa using magnetic resonance elastography (MRE).The prevalence of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis was significantly higher than that in the control population (17.9% vs. 1.4%, P = 0.0032). Compared with controls, the odds of advanced fibrosis among the first-degree relatives of probands with NAFLD-cirrhosis were odds ratio 14.9 (95% CI, 1.8-126.0, P = 0.0133). Even after multivariable adjustment by age, sex, Hispanic ethnicity, BMI, and diabetes status, the risk of advanced fibrosis remained both statistically and clinically significant (multivariable-adjusted odds ratio 12.5; 95% CI, 1.1-146.1, P = 0.0438).Using a well-phenotyped familial cohort, we demonstrated that first-degree relatives of probands with NAFLD-cirrhosis have a 12 times higher risk of advanced fibrosis. Advanced fibrosis screening may be considered in first-degree relatives of NAFLD-cirrhosis patients.140084.National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Environmental Health Sciences, NIH.
Sunitinib Treatment of Renal Adjuvant Cancer (S-TRAC): A Randomized, Double-Blind, Phase III Study of Sunitinib vs. Placebo in Subjects at High Risk of Recurrent Renal Cell Carcinoma (RCC)
Authors: A. Ravaud, R.J. Motzer, H. Pandha, M. Staehler, D.J. George, A. Pantuck, A. Patel, P. Gerletti, L. Chen, J. Patard
Journal: Annals of Oncology (2012)
Prevalence of hepatitis C virus infection in patients with lymphoma.
Authors: Tehseen Iqbal, Parag Mahale, Francesco Turturro, Andreas Kyvernitakis, Harrys A. Torres
Journal: Journal of Clinical Oncology (2015)

e19506 Background: Hepatitis C virus (HCV) is associated with development of B-cell non Hodgkin lymphomas (NHLs). However, association of HCV with specific types of NHL and Hodgkin Lymphoma (HL) is limited. We sought to determine prevalence and association of NHL and HL in HCV-seropositive cancer patients. Methods: In this cross-sectional study, we abstracted data from electronic medical records of cancer patients screened for HCV antibody at MD Anderson Cancer Center during 2004–2013. HCV cases were defined as those who were tested positive for HCV antibody. Infected patients had detectable HCV-RNA, HCV genotype or received HCV treatment. NHL cases were classified for subtype specific analysis using International Classification of Disease for Oncology (ICD-O3) topography and morphology codes. Controls consisted of other non-lymphoma cancer patients tested positive for HCV antibody during the period. Patients with hepatocellular carcinoma were excluded. Results: :Out of 34,545 cancer patients tested for HCV antibody, 8,310 had any type of lymphoma. HCV cases included 173 NHL and 25 HL. Among them, 114(65.8%) NHL and 11(44%) HL had documented HCV infection. Prevalence of HCV-seropositivity was 2.5% in NHL (OR = 1.5, 95% CI = 1.2-1.8, p = 0.003) and 1.9% in HL (OR = 1.1, 95% CI = 0.7-1.7, p = 0.5) patients. Of the total 173 NHL cases, 152 had B-cell NHL (87.8%, OR = 1.6, 95% CI = 1.3-1.9, p < 0.0001) and 21 had T-cell NHL (12.1%, OR = 1.3, 95% CI = 0.8-2, p = 0.1). The most common B-cell NHLs included Diffuse large (DLBCL) (48.5%, OR = 2.2, 95% CI = 1.7-2.8, p < 0.0001), Marginal zone (MZ) (13.3%, OR = 2.4, 95% CI = 1.5-3.7, p = 0.0001) and Follicular (12%, OR = 0.74, 95% CI = 0.5-1.2, p = 0.1). T-cell NHL found were Mycosis fungoides/Sezary syndrome (7.5%, OR = 1.3, 95% CI = 0.6-2.2, p = 0.2) and peripheral T-cell lymphoma (6.9%, OR = 1.7, 95% CI = 0.9-3.1, p = 0.051). The most prevalent HL was Nodular Sclerosis (71%, OR = 1.3, 95% CI = 0.8-2.2, p = 0.1). Conclusions: Patients with NHLs need to be screened for HCV. HCV seropositivity is associated with DLBCL and MZ, but not with T-cell NHLs or HL. The role of HCV in lymphomagenesis requires further research.
Intravenous PPI Treatment: A Reflex Action?
Authors: R Theyventhiran, K Nolan, F Kennedy, C Ridge, D O'Donoghue, H Mulcahy
Journal: Endoscopy (2004)

Aims: The rationale for using intravenous (IV) proton pump inhibitors (PPI's) stems from their efficacy following endoscopic treatment of bleeding peptic ulcer disease, but an American review suggested that nearly 50% of intravenous pantoprazole use was inappropriate. We assessed appropriateness of IV PPI use in an Irish hospital without current local guidelines.
A global research agenda on migration, mobility, and health
Authors: Johanna Hanefeld, Jo Vearey, Neil Lunt, Sadie Bell, Karl Blanchet, Diane Duclos, Ludovica Ghilardi, Daniel Horsfall, Natasha Howard, Jo Hunter Adams, Mphatso Kamndaya, Caroline Lynch, Tackson Makandwa, Nuala McGrath, Moeketsi Modesinyane, Kate O'Donnell, Chesmal Siriwardhana, Richard Smith, Adrienne Testa, Kuda Vanyoro, Helen Walls, Kolitha Prabhash Wickramage, Cathy Zimmermann
Journal: The Lancet (2017)
A Lecture ON WOUND INFECTIONS AND THEIR TREATMENT
Authors: A. E. Wright
Journal: BMJ (1915)

WNOU'ND INFECTIONS AND THEIRE TiIEATMENT.[Nov. 6, I91S lectuLre.Furtlher, it hias been shown that disease of the arteries miiaterially affects tlhe course of most nervous affections at thlis period.Since nervous tissue, once destroyed, canuot b-restored, tlle prevention of vascular disease becomes of paramount imlportance.How tllis is to be accomplished I cannot consider at lengtlh.Often the tendency to vascular disease is hereditary, and beyond our powers to remedy, but apart from suclh cases it is certain thiat the chief mneasures to prevent degenerative clhanges in the circulatory system are abstemiousness in eating and dlrinlkinog, care to keep efficienit the organs of digestion and excretiona, and regular physical exercise.The simple life may prevent, and certainly mitigates, the progress of vasculaF decay.Again, grantularl kidney, a disease for which unfor- tunately our treatmllent is merely palliative and not pre.venitive, is tlhe cause of a-large proportion of cases of cerebral haeimorrlhage.Wlhilst on the one hand over- feeding has to be avoided, on the other excessive work witlh insufficient niutrition is also a danger.Exhaustion, over-fatigue, or overstrain are doubtless causes of such liseases as the muscular atrophies in later life.The need for m-oderation of former activities, both mental and phy.sical, is a lesson that many learn too late.Defect of nutrition, again, may be local in the nervous system from defective supply of blood, due to localized arterial disease.TuLrning fromi tlle vascular degenerations to those affec- tioins miiore purely of nervous origin, the period from 50 to 70 compares favourably witlh that of either childllood and adolescence or the age from 25 to 50.In botlh the latter periods falls the incidence of tlle nervous diseases (lue to infections and iintoxications, from which the aae after 50 is mostly exemiipt.Thle main period of onset of the hereditary and familial diseases, those included under Gowers's designation of " abiotrophy," occurs in childhlood or adolescence; whilst from 25 to 50, together withl some abiotrophic diseases wlhose onset is late, the numerous nervous affections due to syphilis anid alcolhol are rife.We lhave seen tllat, witlh regard to syphilis after 50, the (-hances of the occurrence of cerebro-spinal syphilis are comlparatively slight.Lastly, the purely niervous diseases which are especially clharacteristic of this period of life are paralysis agitans, some of the combined scleroses of the spinal cord, and certain miiscular atroplhies of central origin.It is possible that sonme of these affectionis owve their origin to that process of premature senescence or defective vital en- dutirance of -certain neuronic systemns known as ahiotroply, and that this patlhological process may occur at aniy age.Paralysis agitans especially, in its narrow age incidence, uniformity of symiiptoms, steadily progressive clharacter, and occasional familial tendency, suggests this mode of origin.
Loss of Cardioprotective Effects at the <i>ADAMTS7</i> Locus as a Result of Gene-Smoking Interactions
Authors: Danish Saleheen, Wei Zhao, Robin Young, Christopher P. Nelson, WeangKee Ho, Jane F. Ferguson, Asif Rasheed, Kristy Ou, Sylvia T. Nurnberg, Robert C. Bauer, Anuj Goel, Ron Do, Alexandre F.R. Stewart, Jaana Hartiala, Weihua Zhang, Gudmar Thorleifsson, Rona J. Strawbridge, Juha Sinisalo, Stavroula Kanoni, Sanaz Sedaghat, Eirini Marouli, Kati Kristiansson, Jing Hua Zhao, Robert Scott, Dominique Gauguier, Svati H. Shah, Albert Vernon Smith, Natalie van Zuydam, Amanda J. Cox, Christina Willenborg, Thorsten Kessler, Lingyao Zeng, Michael A. Province, Andrea Ganna, Lars Lind, Nancy L. Pedersen, Charles C. White, Anni Joensuu, Marcus Edi Kleber, Alistair S. Hall, Winfried März, Veikko Salomaa, Christopher O’Donnell, Erik Ingelsson, Mary F. Feitosa, Jeanette Erdmann, Donald W. Bowden, Colin N.A. Palmer, Vilmundur Gudnason, Ulf De Faire, Pierre Zalloua, Nicholas Wareham, John R. Thompson, Kari Kuulasmaa, George Dedoussis, Markus Perola, Abbas Dehghan, John C. Chambers, Jaspal Kooner, Hooman Allayee, Panos Deloukas, Ruth McPherson, Kari Stefansson, Heribert Schunkert, Sekar Kathiresan, Martin Farrall, Philippe Marcel Frossard, Daniel J. Rader, Nilesh J. Samani, Muredach P. Reilly
Journal: Circulation (2017)

Background: Common diseases such as coronary heart disease (CHD) are complex in etiology. The interaction of genetic susceptibility with lifestyle factors may play a prominent role. However, gene-lifestyle interactions for CHD have been difficult to identify. Here, we investigate interaction of smoking behavior, a potent lifestyle factor, with genotypes that have been shown to associate with CHD risk. Methods: We analyzed data on 60 919 CHD cases and 80 243 controls from 29 studies for gene-smoking interactions for genetic variants at 45 loci previously reported to be associated with CHD risk. We also studied 5 loci associated with smoking behavior. Study-specific gene-smoking interaction effects were calculated and pooled using fixed-effects meta-analyses. Interaction analyses were declared to be significant at a P value of &lt;1.0×10 –3 (Bonferroni correction for 50 tests). Results: We identified novel gene-smoking interaction for a variant upstream of the ADAMTS7 gene. Every T allele of rs7178051 was associated with lower CHD risk by 12% in never-smokers ( P =1.3×10 –16 ) in comparison with 5% in ever-smokers ( P =2.5×10 –4 ), translating to a 60% loss of CHD protection conferred by this allelic variation in people who smoked tobacco (interaction P value=8.7×10 –5 ). The protective T allele at rs7178051 was also associated with reduced ADAMTS7 expression in human aortic endothelial cells and lymphoblastoid cell lines. Exposure of human coronary artery smooth muscle cells to cigarette smoke extract led to induction of ADAMTS7. Conclusions: Allelic variation at rs7178051 that associates with reduced ADAMTS7 expression confers stronger CHD protection in never-smokers than in ever-smokers. Increased vascular ADAMTS7 expression may contribute to the loss of CHD protection in smokers.
Long Term Safety and Efficacy of Recombinant Factor IX Fc Fusion Protein (rFIXFc) Prophylaxis in Children with Hemophilia B: Interim Results of the B-Yond Extension Study
Authors: Jonathan M. Ducore, Kathelijn Fischer, Roshni Kulkarni, Beatrice Nolan, Carolyn M. Bennett, David J Perry, Huixing Yuan, Alejandra Ramirez-Santiago, Francesca Ferrante, Stefan Lethagen
Journal: Blood (2016)
Frederic Edward Mohs, MD—The Pioneer of Chemosurgery
Authors: Anshum Sood, Varun Ayyaswami, Arpan V. Prabhu, Thomas G. Benedek
Journal: JAMA Dermatology (2017)

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Accumulation of classical monocytes defines a subgroup of MDS that frequently evolves into CMML
Authors: Dorothée Selimoglu-Buet, Bouchra Badaoui, Emmanuel Benayoun, Andréa Toma, Pierre Fenaux, Bruno Quesnel, Gabriel Etienne, Thorsten Braun, Nassera Abermil, Margot Morabito, Nathalie Droin, Eric Solary, Orianne Wagner-Ballon
Journal: Blood (2017)