tbuckley/cabot-search huggingface dataset:
Efficacy of repeated injections of CLR 131 (I-131-CLR1404) in a MES SA/Dx5 athymic nude mouse model.
Authors: Katherine Oliver, Jarrod Longcor, Irawati Kandela
Journal: Journal of Clinical Oncology (2017)

e14091 Background: CLR 131 is a novel radioiodinated therapeutic that exploits the selective uptake and retention of phospholipid ethers (PLEs) by malignant cells. Uterine sarcoma (MES SA/Dx5) cells express high levels of P-gp and are known to be a doxorubicin resistant cell line. The cells exhibit a marked cross resistance to several chemotherapy drugs including vinblastine, Taxol ® , vincristine, etc. This study evaluates the effect of repeated injections of CLR 131 in MES SA/Dx5 tumor bearing mice and evaluate the ability of CLR 131 to overcome resistance caused by over-expression of the P-gp Multi Drug Resistance (MDR) ‘pump’. Methods: The MES SA/Dx5 cell line (human uterine sarcoma) was purchased from American Type Culture Collection (Rockville, MD) and maintained in McCoy’s 5a media supplemented with 10% fetal bovine serum. Female athymic nude mice (Crl: NU-Foxn1nu); approximately 4-5 weeks of age and between 16-18 g (Charles River, Portage, MI) were injected subcutaneously with 2x10 6 viable cells (in ~100 µL Dulbecco’s PBS) into the right flank. The study was initiated when tumor size had reached a pre-determined size (approximately 50-150 mm 3 ). The mice were given potassium iodide at a concentration of 0.1% in their drinking water to block possible free iodide in the drug formulation. Doses of ~130 µCi and ~145 µCi of CLR 131were given at Day 0 and Day 7 (N = 6 in treatment group, N = 5 in control group). A single control dose of ~130 µCi of I-127-CLR1404 was given via tail vein injection on Day 0. Results: Tumor growth of the treatment group was significantly inhibited. The control group showed exponential growth throughout the study, increasing in volume by an average 21 fold from baseline to day 22 (all control mice died day 23). This compared with a 6 fold increase from baseline in the treatment group. Conclusions: The results of the study indicated that multiple injections of CLR 131 on human uterine sarcoma (MES SA/Dx5) tumor bearing model showed a significant inhibition of tumor growth as well as significant survival benefit. The implication is that in this clinically predictive in vivo model CLR 131 is not susceptible to the MDR “pump” and thus CLR 131 might show clinical efficacy in patients with MDR cancer due to P-gp overexpression.
CYFRA 21–1 (CYFRA) as a prognostic and predictive marker in advanced non-small cell lung cancer (NSCLC): CALGB 150304
Authors: P. Y. Rosenblatt, M. J. Edelman, R. H. Christenson, L. Hodgson, X. Wang, R. Kratzke, E. Vokes
Journal: Journal of Clinical Oncology (2009)

11020 Background: Cytokeratin 19 and its soluble fragment CYFRA have been studied as markers that may correlate with response to therapy and survival in NSCLC. As part of CALGB 30203, a randomized trial of carboplatin/gemcitabine with eicosanoid modulators (celecoxib, zileuton or both) in advanced NSCLC (Edelman JCO 2008), serum CYFRA levels were obtained prior to and during treatment. The objective of this study was to evaluate the possible correlation of CYFRA as a predictive and prognostic marker and to confirm a previous finding that a 27% reduction in CYFRA after one cycle (21 days) of treatment correlated with a longer survival (Vollmer Clin Ca Res, 2003). Methods: Paired specimens were available from 88 patients. CYFRA was measured at baseline and after cycles 1 and 2 using an electrochemoluminescent assay (Roche Diagnostics) on the ElecSys 2010 system as previously described. Using logarithm of the initial concentration and logarithm of the difference in concentrations, we analyzed these in relation to overall survival (OS) and failure free survival (FFS). Results: 1. Lower baseline CYFRA levels were associated with both longer overall survival and failure free survival (p = &lt;0.0001 and p=0.0045). 2. Larger reductions in CYFRA levels correlated to longer overall survival and failure-free survival (p=0.0254 and p=0.0298). 3.We failed to replicate that a drop of &gt;27% in CYFRA levels had statistical significance in overall or failure free survival (p=0.6489 and p=0.9636). Conclusions: CYFRA and change in CYFRA appear to be reliable markers in predicting the response to chemotherapy for nonsmall cell lung cancer; however, a precise threshold to mark response has yet to be determined. No significant financial relationships to disclose.
EXTREME SPORTS, EXTREME RISKS. FATALITIES IN EXTREME SPORTS IN AUSTRALIA
Authors: Andrew McIntosh, Lauren Fortington, Declan Patton, Caroline Finch
Journal: British Journal of Sports Medicine (2017)

Background Extreme sports are popular and include motorised and non-motorised vehicle sports, e.g. motocross, mountain biking and water skiing, as well as non-vehicle sports, e.g. rock climbing. The causes of death, contributing factors and potential to prevent deaths in extreme sports are poorly understood. Objective To understand the causes of death and contributing factors in extreme sports in Australia. Design A case-series analysis was undertaken using the National Coronial Information System (NCIS) in Australia. Setting Extreme sports, including recreational and professional participants. Patients Cases are ‘closed’ NCIS fatal cases aged 15 to 64 years who died in the period 2000 to 2016 while participating in an extreme sport. Interventions None. Main Outcome Measurements Theses include the cause of death, mechanism of injury, contributing factors, demographic data, case narratives, and sport participation. Results Using a narrow definition of extreme sports (i.e. including sports such as kayaking, paragliding, rock climbing, snow sports and mountain biking) there were 693 deaths. Using a broader definition of extreme sports, e.g. including sports such as diving, horse racing, motor racing and quad bike use, there were 995 deaths during the same period. Approximately 88% of cases in either analysis (broad or narrow) were males, with age distributed relatively evenly from 15 to 54 years. The largest two broad sports categories were individual water sports (including surfing/boogie board 120/693) and wheeled motor sports (including motorcycling 192/693), combined accounting for over half of all cases in either analysis. There were over 50 deaths in skydiving/paragliding/parasailing. Blunt force trauma was the main cause of death, 65% of 693, followed by drowning 20% and cardiac 11%. Conclusions The potential for preventing a proportion of blunt force trauma and drowning deaths through controls, such as event planning, individual preparation and equipment, will be examined based on the case narratives.
Human Rabies—California, Georgia, Minnesota, New York, and Wisconsin, 2000
Journal: JAMA (2001)

OUTBREAKS OFPseudomonas aeruginosa dermatitis and otitis externa associated with swimming pool and hot tub use occurred in Colorado and Maine.This report summarizes these outbreaks and provides recommendations for swimming pool and hot tub operation and maintenance, particularly when using offsite monitoring of water disinfectant and pH levels or when cyanuric acid is added to pools as a chlorine stabilizer. ColoradoIn February 1999, the Colorado Department of Public Health and Environment (CDPHE) was notified of approximately 15 persons with folliculitis after they had used a hotel pool and hot tub.The cases occurred among children and adults attending two birthday parties at the hotel and among community residents who entered the pool on a pay-to-swim basis.The patients were treated for suspected Pseudomonas skin infections; one patient tested positive for Pseudomonas sp. by culture of a skin lesion.Twenty-five community residents who used the pool and/or hot tub during February 5-7 were identified through discussions with area physicians, hotel management, and other swimmers.These community residents were interviewed by CDPHE using a telephone questionnaire.Casepatients were defined as persons who
Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability
Authors: Erna V Ivarsdottir, Valgerdur Steinthorsdottir, Maryam S Daneshpour, Gudmar Thorleifsson, Patrick Sulem, Hilma Holm, Snaevar Sigurdsson, Astradur B Hreidarsson, Gunnar Sigurdsson, Ragnar Bjarnason, Arni V Thorsson, Rafn Benediktsson, Gudmundur Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Sirous Zeinali, Fereidoun Azizi, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, Kari Stefansson
Journal: Nature Genetics (2017)
クモ膜下出血後の脳底動脈において新規トロンビン受容体拮抗薬はトロンビンに対する血管攣縮反応を予防した(A Novel Thrombin Receptor Antagonist Prevented Vasospastic Response to Thrombin in the Basilar Artery after Subarachnoid Hemorrhage)
Authors: Surmely Jean-Francois, Nasu Kenya, Fujita Hiroshi, Terashima Mitsuyasu, Tsuchikane Etsuo, Matsubara Tetsuo, Ehara Mariko, Ito Tatsuya, Kinoshita Yoshihisa, Takeda Yoshihiro, Tanaka Nobuyoshi, Murata Akira, Katoh Osamu, Suzuki Takahiko
Journal: Circulation (2006)
The Skin of Our Teeth
Authors: Leonard J. Hoenig
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
AB1229-HPR Evaluation of rheumatology nurse-led clinic in managing patients with rheumatoid arthritis: a retrospective study
Authors: YME Leung, KY Wong, LS Tam
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease characterized by inflammation of the synovial joints. Management of RA patients are usually provided by rheumatologists only. Enhanced care provided by rheumatology nurses between rheumatologist consultations may have beneficial effects in terms of symptom control. In Hong Kong, whether rheumatology nurse care model can favor to patient outcomes remained uncertain. <h3>Objectives</h3> The aim of the study was to examine the clinical effectiveness of rheumatology nurse clinic in controlling disease activity as expressed in change of Disease Activity Score in 28 joints in RA patients compared with usual care led by rheumatologists only. <h3>Methods</h3> This was a retrospective study. Two historical groups of RA patients (30 patients at each group) were identified from attendance records between 1/1/2015 and 20/7/2015 at the rheumatology outpatient clinics. Group 1 comprised of patients who attended rheumatology nurse clinic in between the doctor clinic consultations. Patient education delivered by the rheumatology nurse included disease mechanism, treatment aim, pain management and checking medication adherence according to prescription. RA treatment could also be intensified if needed. Group 2 comprised of patients managed by rheumatologists only. Primary outcomes were changes in disease activity at follow-up visit after the doctor clinic and nurse clinic. <h3>Results</h3> The mean follow-up duration for the study cohort was 20 weeks (median: 22.5 weeks). Patient global assessment and DAS 28 were similar for both groups at baseline. At follow-up, patient global assessment and in the nurse group (Group 1) decreased from mean ± SD: 42±24.7 at baseline to 28.7±24.6 at follow-up, which was approaching the minimal clinically important improvement (MCII= -15). With regards to DAS28, there was a 8.2% decrease (absolute change: -0.38±1.14) in DAS28 in group 1 suggesting a trend of improvement (p=0.081). The corresponding decrease in group 2 was 1.2% (absolute change: -0.05±1.47) and such decrease was not significant (p=0.863). Changes in DAS28 did not exceed minimal clinically important improvement in both groups (MCII= -1.2). <h3>Conclusions</h3> This study demonstrates the short-term benefit of a nurse-led program on RA disease management. Future multi-center studies with a randomized controlled design and a larger sample will be required to confirm our findings. <h3>Acknowledgements</h3> The author is very grateful to the supervisors from, Professor Wong Kam Yuet, Frances, Hong Kong Polytechnic University; Professor Tam Lai Shan and Dr Zhu Yaner, Tracy the Chinese University of Hong Kong. Lastly, the author would like to thank her parents and friends for their support. <h3>Disclosure of Interest</h3> None declared
The physical activity paradox: six reasons why occupational physical activity (OPA) does not confer the cardiovascular health benefits that leisure time physical activity does
Authors: Andreas Holtermann, Niklas Krause, Allard J van der Beek, Leon Straker
Journal: British Journal of Sports Medicine (2017)

Physical activity (PA) is well documented to improve health. However, this documentation is restricted to leisure time physical activity (LTPA; eg, sports, recreation and transportation). Increasing evidence shows that occupational physical activity (OPA) does not improve health.1 Actually, OPA can be detrimental. These contrasting health effects of LTPA and OPA constitute the so-called PA health paradox.2 

For a considerable fraction of the adult population, work constitutes the main setting for PA. Workers in many occupations, such as construction, cleaning, refuse collection, elderly care, farming and manufacturing, are physically active for large parts of their working days, for most of the year. Despite this PA at work, these and other manual workers have relatively poor health.

Many epidemiological studies document that high OPA increases the risk for cardiovascular disease (CVD) and mortality outcomes, even after extensive adjustments for other risk factors including socioeconomic status, LTPA and other health behaviours.1 This increased risk from high OPA has been shown to be particularly pronounced among workers with low job resources, low cardiorespiratory fitness3 or pre-existing …
USING NATIONAL CORONIAL DATA TO IDENTIFY PRIORITIES FOR PREVENTING DEATH IN SPORT/RECREATION
Authors: Andrew McIntosh, Lauren Fortington, Declan Patton, Caroline Finch
Journal: British Journal of Sports Medicine (2017)

Background Deaths relating to sport/recreation are thought to be rare. However, in Australia, a lack of published data has limited our understanding of the number of deaths in different sports and settings. Objective To gain a first understanding of the number/cause of deaths across different sports/recreation activities in Australia. Design A case-series analysis was undertaken using the National Coronial Information System (NCIS) in Australia. Setting All sport and physical recreation activities in Australia as coded in the NCIS, including recreational and professional participants. Patients Cases are ‘closed’ NCIS cases of all ages who died in the period 2000 to 2016 as a result of participating in sport and physical recreation. Cases were selected from NCIS activity level one categories – Sport and Exercise During Leisure Time, Education, Leisure or Play and Paid Work. Interventions None. Main Outcome Measurements The number of deaths by sport/recreation activity and associated demographic data (e.g. sex, age). The cause, mechanism of injury and contributing factors are explored. Results 5060 cases were included. The three most frequent activities were “Individual water sports” (42%), “Individual athletic activities” (9%) and “wheeled non-motor sports” (7%). Combined, team bat/stick and team ball sports contributed 7% of cases. Males accounted for 88% of cases. The proportion of deaths by age increased from 4% in 5–14 year olds, peaked at 19% in 45–54 year olds, before declining. The most common causes were identified as cardiac-related (39%), drowning (34%) and blunt force trauma (19%.) Conclusions There is demonstrable evidence from other injury settings for data to inform safety measures that can prevent fatalities. These results provide a first understanding of the people/activities most often impacted by death in different sports settings across Australia. With this information, leading activity contexts and causes will be explored to identify common mechanisms and potential prevention priorities and strategies.
BIOMECHANICAL ANALYSIS OF SINGLE-LEG SQUAT WITH ISOKINETIC AND CONSTANT RESISTIVE FORCE USING CONTROLLABLE EXERCISE EQUIPMENT
Authors: Yoshinori Kimura, Maki Koyanagi, Ken'ichi Koyanagi, Kouichi Mukai, Naruhiko Nakae, Noriko Tanaka, Takahiro Sakai, Shuhei Tada, Yumiko Satoda, Sayaka Kondou, Akio Inoue
Journal: British Journal of Sports Medicine (2017)

Background We have reported that a resistive single-leg squat (RSLS) exercise using exercise equipment that generates various resistance forces was effective for increasing the load on the gluteus medius and preventing knee valgus moment. However, the biomechanical characteristics of RSLS with each resistance forces have not been compared. Objective To compare difference of the biomechanical characteristics of RSLS between isokinetic resistance force (IF) and constant resistance force (CF). Design Quasi-experimental. Setting Controlled laboratory setting. Participants Six asymptomatic female college students. Interventions Participants performed RSLS with IF and CF. A motion capture system and force plate were used for motion analysis. Surface electrodes recorded the EMG activity of the muscles of the support leg. Main Outcome Measurements Joint moment of the support leg were calculated from 20° to 60° of knee flexion at 10° intervals. EMG data were normalized as a percentage of maximum voluntary contraction. Results In both the tasks, external knee valgus moment was prevented. Peak internal hip abduction moment was larger in IF (2.3±0.4 Nm/kg) than in CF (1.91±0.3 Nm/kg). Internal hip abduction moment was significantly larger in CF (1.4±0.2 Nm/kg) than in IF (1.1±0.3 Nm/kg) at 20° knee flexion, but larger in IF than in CF at 50° and 60° knee flexion. No significant difference in internal hip abduction moment was found at 30° and 40° knee flexion. EMG activities were significantly larger in IF (rectus femoris, 56±16%; vastus medialis, 85±38%; gluteus medius, 85±17%) than in CF (rectus femoris, 34±10%; vastus medialis, 48±23%; gluteus medius, 59±12%). Conclusion: IF was more useful for augmenting the activity of major muscles in the support leg and internal hip abduction moment at large knee flexion angles, whereas CF was more useful for augmenting internal hip abduction moment at small knee flexion angles, where ACL injury frequently occurs.
The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer
Authors: Wanjin Li, Zihan Zhang, Xinhua Liu, Xiao Cheng, Yi Zhang, Xiao Han, Yu Zhang, Shumeng Liu, Jianguo Yang, Bosen Xu, Lin He, Luyang Sun, Jing Liang, Yongfeng Shang
Journal: Journal of Clinical Investigation (2017)

The pathophysiological function of the forkhead transcription factor FOXN3 remains to be explored. Here we report that FOXN3 is a transcriptional repressor that is physically associated with the SIN3A repressor complex in estrogen receptor–positive (ER+) cells. RNA immunoprecipitation–coupled high-throughput sequencing identified that NEAT1, an estrogen-inducible long noncoding RNA, is required for FOXN3 interactions with the SIN3A complex. ChIP-Seq and deep sequencing of RNA genomic targets revealed that the FOXN3-NEAT1-SIN3A complex represses genes including GATA3 that are critically involved in epithelial-to-mesenchymal transition (EMT). We demonstrated that the FOXN3-NEAT1-SIN3A complex promotes EMT and invasion of breast cancer cells in vitro as well as dissemination and metastasis of breast cancer in vivo. Interestingly, the FOXN3-NEAT1-SIN3A complex transrepresses ER itself, forming a negative-feedback loop in transcription regulation. Elevation of both FOXN3 and NEAT1 expression during breast cancer progression corresponded to diminished GATA3 expression, and high levels of FOXN3 and NEAT1 strongly correlated with higher histological grades and poor prognosis. Our experiments uncovered that NEAT1 is a facultative component of the SIN3A complex, shedding light on the mechanistic actions of NEAT1 and the SIN3A complex. Further, our study identified the ERα-NEAT1-FOXN3/NEAT1/SIN3A-GATA3 axis that is implicated in breast cancer metastasis, providing a mechanistic insight into the pathophysiological function of FOXN3.
Résection muqueuse endoscopique (RME) de polypes plans du colon droit (&gt; 10mm). Utilisation d’un produit d’injection coloré à l’indigo carmin
Authors: A Amiot, D Parlier, S Chaussade
Journal: Endoscopy (2004)

Introduction: Les adénomes plans, souvent situés dans le colon droit (50%), sont de nature villeuse dans 68% des cas [1]. Ces deux facteurs, avec la taille du polype, sont associés à un risque de récidive élevé après résection muqueuse endoscopique (RME). L’utilisation d’un produit d’injection sous muqueuse coloré à l’indigo carmin pourrait permettre de visualiser précisément les limites de la lésion et de faciliter sa résection complète. L’objectif est d’évaluer la RME de polype du colon droit avec un produit d’injection coloré à l’indigo carmin. Patients et Méthodes: Etude prospective chez 22 patients atteints de polype plan > 10 mm du colon droit. L’évaluation a porté sur le taux de résectionmacroscopique et microscopique, de complications et de récidives à moyen terme.