tbuckley/cabot-search huggingface dataset:
FDA Approval Summary: Sonidegib—Response
Authors: Stacy S. Shord, Denise Casey, Hong Zhao, Suzanne Demko, Patricia Keegan, Richard Pazdur
Journal: Clinical Cancer Research (2017)

Race and ethnicity are important considerations during drug development, with differential effects in drug exposure, efficacy, and safety across racial groups observed for some drugs. Gyawali and Ando ([1][1]) suggest that the recommended dose of 200 mg once daily for sonidegib may not be
Epidemiología de la enfermedad meningocócica en Inglaterra y Gales, 1.996 y 1.997
Authors: M E Ramsay, M Collins, M Rush, E Kaczmarksi
Journal: Eurosurveillance (1997)

La vigilancia de la infeccion meningococica en Inglaterra y Gales se basa en tres fuentes de datos. Los medicos estan obligados por ley a declarar casos de meningitis meningococica diagnosticados clinicamente y, desde 1.989, tambien deben declarar casos de septicemia meningococica (en ausencia de meningitis) al consultor local del centro de control de enfermedades transmisibles (CCDC).
Safety vs Efficacy of Lowering Blood Pressure
Authors: Chirag Bavishi, Sripal Bangalore, Franz H. Messerli
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Risk of Cardiovascular Ischemic Events After Surgical Castration and Gonadotropin-Releasing Hormone Agonist Therapy for Prostate Cancer: A Nationwide Cohort Study
Authors: Dong-Yi Chen, Lai-Chu See, Jia-Rou Liu, Cheng-Keng Chuang, See-Tong Pang, I-Chang Hsieh, Ming-Shien Wen, Tien-Hsing Chen, Yung-Chang Lin, Chuang-Chi Liaw, Cheng-Lung Hsu, John Wen-Cheng Chang, Chang-Fu Kuo, Wen-Kuan Huang
Journal: Journal of Clinical Oncology (2017)

Purpose Our aim was to determine whether cardiovascular (CV) risk in patients with prostate cancer (PCa) differs between those who receive androgen-deprivation therapy by surgical castration and those who receive gonadotropin-releasing hormone agonist (GnRHa) therapy. Patients and Methods By using the Taiwan National Health Insurance Research Database, we analyzed data from 14,715 patients with PCa diagnosed from January 1, 1997, through December 31, 2011. The patients were treated with bilateral orchiectomy or GnRHa therapy. We used inverse probability of treatment weighting with propensity scores to adjust for the imbalance in covariate baseline values between these two groups. Cox regression models were used to identify risk factors for myocardial infarction (MI), ischemic stroke (IS), and cardiac-related complications. Results Overall, 3,578 patients with PCa (24.3%) underwent bilateral orchiectomy and 11,137 patients (75.7%) received GnRHa therapy. Both groups had a similar risk of CV ischemic events (ie, MI or IS; hazard ratio, 1.16; 95% CI, 0.97 to 1.38) during a median follow-up time of 3.3 years. However, during the first 1.5 years of follow-up, there were higher CV ischemic events in the orchiectomy group than in the GnRHa group (hazard ratio, 1.40; 95% CI, 1.04 to 1.88), particularly in patients who were ≥ 65 years of age, had hypertension, had a Charlson comorbidity index score ≥ 3, and had a previous history of MI, IS, or coronary heart disease. Conclusion Compared with bilateral orchiectomy, use of GnRHa does not increase the risk of CV ischemic events in patients with PCa. Nonetheless, orchiectomy is associated with higher rates of CV ischemic events in older patients and those with a history of CV comorbidities within 1.5 years of initiating androgen-deprivation therapy. These findings can help clinicians decide on the optimal castration strategy for individual patients.
A systematic rapid autopsy program tracks temporal and spatial heterogeneity of human tumors and identifies mechanisms of resistance to targeted therapies
Authors: C.S. Walmsley, D. Juric, A. Bardia, L. Henderson, J. Gurski, J.R. Stone, C. Pinto, S.J. Isakoff, D.M. Fitzgerald, J.F. Gainor, L. Goyal, M. Broudo
Journal: Annals of Oncology (2017)
Widespread distribution of mcr-1-bearing bacteria in the ecosystem, 2015 to 2016
Authors: Kaichao Chen, Edward Wai-Chi Chan, Miaomiao Xie, Liangwei Ye, Ning Dong, Sheng Chen
Journal: Eurosurveillance (2017)

The recently discovered colistin resistance-encoding element, mcr-1, adds to the list of mobile resistance genes whose products rapidly erode the antimicrobial efficacy of not only the commonly used antibiotics, but also the last line agents of carbapenems and colistin. The relative prevalence of mcr-1-bearing strains in various ecological niches including 1,371 food samples, 480 animal faecal samples, 150 human faecal samples and 34 water samples was surveyed using a novel in-house method. Bacteria bearing mcr-1 were commonly detected in water (71% of samples), animal faeces (51%), food products (36%), and exhibited stable carriage in 28% of human subjects surveyed. Such strains, which exhibited variable antibiotic susceptibility profiles, belonged to various Enterobacteriaceae species, with Escherichia coli being the most dominant in each specimen type. The mcr-1 gene was detectable in the chromosome as well as plasmids of various sizes. Among these, two conjugative plasmids of sizes ca 33 and ca 60 kb were found to be the key vectors that mediated mcr-1 transmission in organisms residing in various ecological niches. The high mcr-1 carriage rate in humans found in this study highlights the importance of continued vigilance, careful antibiotic stewardship, and the development of new antimicrobials.
Antimitogenic effects of the methylation inhibitor zebularine on ovarian carcinoma cell lines
Authors: Curtis Balch, Min Choi, Kenneth P. Nephew
Journal: Cancer Research (2004)

1606  The cytidine analog zebularine has been shown to possess potent antitumor effects in a bladder carcinoma xenograft model. These effects were due to a global inhibition of DNA methylation, as demonstrated by demethylation and reactivation of the tumor suppressor gene p16. In this study, we examined the effects of zebularine (kindly provided by Dr. Victor Marquez, National Cancer Institute) on a panel of ovarian carcinoma cell lines, using cell proliferation (MTT) assays, flow cytometry, and quantitative RT-PCR (qRT-PCR) analysis of expression of various tumor suppressor genes. Zebularine (0.1- 1.0 mM) was strongly antiproliferative (>65% growth inhibition at 1 mM) to the ovarian carcinoma cell lines CP70 and A2780, following 48 hour of treatment, with lesser antimitogenic effects on normal ovarian surface epithelial (nOSE) cells. This growth inhibition was, in part, due to G2/M cell cycle arrest, with a corresponding decrease (50%) in S phase distribution, as determined by flow cytometry. Similar to T24 bladder carcinoma cells, zebularine (48 hr, 0.5 mM) treatment caused a modest increase (4-fold) in expression of p16, in addition to upregulation of the tumor suppressor RASSF1A (10-fold), as measured by qRT-PCR. A dramatic induction of the mismatch repair enzyme-encoding gene hMLH-1 was also observed following a 0.5 mM drug treatment for 48 hr. To investigate zebularine as a potential therapy for treatment of drug resistant ovarian tumors, we also performed cisplatin resensitization studies using drug-resistant CP70 cells. As a consequence of our in vitro findings, that zebularine is a potent antimitogen to ovarian carcinoma cultures, the potential for this drug as an ovarian cancer therapeutic is discussed. (Supported by NCI Grant CA085289)
BALAD-2 score for the prediction of survival in patients with hepatocellular carcinoma.
Authors: Kerstin Schuette, Gerhard Treiber, Christian Schulz, Tina Bretschneider, Joerg Arend, Christiane Bruns, Jens Ricke, Peter Malfertheiner
Journal: Journal of Clinical Oncology (2014)

e15091 Background: The prognosis of patients with hepatocellular carcinoma (HCC) is based on multiple factors. They include tumor related factors, liver function and patients´general health status. α-fetoprotein (AFP) is a valuable tool for the prediction of survival in patients with HCC, but is expressed in 60% of patients only. We evaluated a combination of AFP, AFP-L3 (lens culinaris agglutinin-reactive AFP) and des-gamma-carboxy prothrombin (DCP) (measured on a μTASWako i30 auto analyzer (Wako Chemicals GmbH, Neuss, Germany)) with bilirubin and albumin (BALAD-2 score) for the discrimination of survival in patients with HCC (Fox R, et al. Biomarkers based prognosis in hepatocellular Carcinoma: Validation and extension of the BALAD model. In Press.). Methods: In 106 patients with HCC (female n = 14, male n = 82, median age 69 years (y) (range 42-88y) the BALAD-2 score (0.02 x ([AFP] - 2.57) + 0.012 x ([AFP-L3] - 14.19) + 0.19 x (ln[DCP] - 1.93) + 0.17 x ([BIL]1/2 - 4.50) - 0.09 x ([ALB] - 35.11) was calculated. Patients were classified into four groups based on the BALAD-2 score. Patients were followed-up until death or censored at time of last contact (median follow-up 325 days (d), range 0-1758 d). Survival rates were analysed using the Kaplan-Meier method. A separate analysis was performed for the subgroup of patients in whom blood was drawn within 1 months of initial diagnosis (SG, n = 43). Results: At the time of the analysis 44 patients had died. Survival times according to BALAD-2 score are given in the Table. Conclusions: The BALAD-2 score is a valuable score to predict survival in patients with hepatocellular carcinoma, especially if calculated at the time of initial diagnosis. BALAD-2 group Criteria N (all patients) Median survival (months) N (subgroup: patients at initial diagnosis) Median survival (months) 1 Score ≤ -1.74 41 38.7 19 29.6 2 -1.74 < Score ≤-0.91 27 21.8 9 22.3 3 -0.91 < Score ≤ 0.24 26 6.2 11 5.7 4 0.25 < Score 12 11.2 4 2.9 total 106 28.7 43 28.7 p (log-rank) < 0.01 0.006
General practice threatens to withhold repeat prescriptions until patients have flu vaccine
Authors: Gareth Iacobucci
Journal: BMJ (2017)

General practices are being warned not to let their push to deliver flu vaccinations this winter spill over into “bad behaviour,” after a practice was reported to healthcare leaders for threatening to withhold repeat prescriptions from patients until they had been vaccinated there.

The unnamed practice was reported to NHS England and Doncaster Clinical Commissioning Group by local pharmacists, who became aware that patients who were eligible for a flu vaccination had been told that they could not receive drugs on repeat prescription until they had had a flu vaccination at the practice. The practice subsequently withdrew the threat after being warned by commissioners over its conduct. …
A phase II study of combination chemotherapy with cetuximab/S-1/low dose cisplatin as neoadjuvant manner for oral squamous cell carcinoma patients
Authors: M. Nakazawa, T. Imai, Y. Matsumiya, M. Suematsu, Y. Ohta, T. Ohnishi, M. Ohmae, H. Chisoku, I. Kato, S-Y. Tada, A. Takeshita
Journal: Annals of Oncology (2017)
Shiga toxin-producing Escherichia coli: incidence and clinical features in a setting with complete screening of patients with suspected infective diarrhoea
Authors: R.M. Pedersen, M.T.K. Nielsen, S. Möller, S. Ethelberg, M.N. Skov, H.J. Kolmos, F. Scheutz, H.M. Holt, F.S. Rosenvinge
Journal: Clinical Microbiology and Infection (2017)
Surveillance renforcée des maladies infectieuses : l’expérience de la coupe du monde 2006 de la FIFA, Allemagne
Authors: K Schenkel, C Williams, T Eckmanns, G Poggensee, J Benzler, J Josephsen, G Krause
Journal: Eurosurveillance (2006)

La coupe du monde de football 2006 de la FIFA a eu lieu dans 12 villes allemandes entre le 9 juin et le 9 juillet 2006. Nous avons identifie le besoin de rendre plus reactif et sensible le systeme de surveillance des maladies infectieuses existant, afin de detecter a temps les evenements de sante survenant pendant la coupe du monde. Une surveillance renforcee, basee sur le systeme existant de declaration obligatoire, a ete mise en place entre le 7 juin et le 11 juillet 2006 dans les 12 villes accueillant la coupe du monde. Une transmission electronique quotidienne, et non plus hebdomadaire, des donnees sur les cas de maladies a declaration obligatoire (d’apres les definitions de cas) ; une declaration de toutes les infections independamment des definitions de cas. De plus, la presse grand public et la presse specialisee ont ete passees au crible et la communication entre les acteurs du systeme de surveillance a ete renforcee. Le delai moyen pour la transmission des donnees de notification depuis la communaute jusqu’au niveau federal a ete reduit de trois a un jour. Une epidemie de norovirus a ainsi ete detectee au sein du Centre international de radio-television a Munich, avec 61 cas lies epidemiologiquement dans la premiere semaine suivant les premiers symptomes, et quatre cas isoles lies a la coupe du monde, dont deux relevaient du Reglement sanitaire international. Apres la coupe du monde, tous les acteurs de la surveillance ont constate que la communication entre les differents niveaux (local, d’etat et federal) s’etait considerablement amelioree. A la difference de la majorite des responsables sanitaires de rencontres de masse de la derniere decennie, nous n’avons pas mis en place de surveillance syndromique. Neanmoins, le renforcement de la surveillance des maladies infectieuses a permis de detecter rapidement les evenements sanitaires pendant la coupe du monde de la FIFA. De plus, l’exercice de communication et de mise en reseau realise a cette occasion s’est montre performant pour gerer des evenements representant une menace pour la sante. Nous recommandons de poursuivre la transmission quotidienne des donnees de notification dans le cadre de la surveillance en routine des maladies infectieuses en Allemagne.
Long-term efficacy of denosumab in giant cell tumor of bone: Results of an open-label phase 2 study
Authors: E. Palmerini, J-Y. Blay, A. Le Cesne, P. Reichardt, P. Rutkowski, H. Gelderblom, R.J. Grimer, A. Feng, D. Jandial, S. Chawla
Journal: Annals of Oncology (2017)
Avelumab in patients with metastatic adrenocortical carcinoma (mACC): Results from the JAVELIN solid tumor trial
Authors: C. Le Tourneau, C. Zarwan, C. Hoimes, D.J. Wong, S. Bauer, M. Wermke, H.J. Grote, A. von Heydebreck, K. Chin, J. Gulley
Journal: Annals of Oncology (2017)
Characterization of cancer stem cell and immune microenvironment interactions in non-small cell lung cancer (NSCLC)
Authors: S. Torres, R. Sirera, C. Aguilar, S. Calabuig Fariñas, M. Mosqueda, A. Herreros-Pomares, E. Escorihuela, E. García del Olmo, E. Jantus-Lewintre, C. Camps Herrero
Journal: Annals of Oncology (2017)
Epidémie d’infections à Salmonella enteritidis lysotype 1 chez des touristes à Majorque, juin 1996
Authors: P Wall, L Ward, S Crespi, C Furtado
Journal: Eurosurveillance (1997)

Trois touristes britanniques devinrent malades pendant leur sejour du 11 au 25 juin 1996 dans un hotel d’Alcudia a Majorque ; des infections a Salmonella enteritidis furent diagnostiquees a leur retour en Angleterre. Le 10 juillet 1996, un inspecteur de sante-environnement informait la Division des Maladies Gastro-intestinales du PHLS Communicable Disease Surveillance Centre (CDSC). Le CDSC contactait un microbiologiste a Alcudia, qui declara qu’il avait enquete sur une epidemie de gastro-enterites dans cet hotel au moment ou les trois clients britanniques y residaient. Il s’agit d’un hotel de grande taille destine uniquement aux vacanciers britanniques, les sejours comprenant generalement le petit dejeuner et le diner. Les vacanciers qui souffrent de gastro-enterite pendant leur sejour peuvent consulter un medecin generaliste local qui se deplace a l’hotel. La plupart des cas recoivent des traitements symptomatiques et les prelevements de selles ne sont pas realises en routine. Seuls les cas severes sont envoyes a l’hopital.
Ability of TMPRSS2-ERG (TE) expression to predict taxane benefit depending on prior abiraterone or enzalutamide therapy in castration-resistant prostate cancer
Authors: M. Marín-Aguilera, O. Reig, A. Font, A. Rodríguez-Vida, C. Suárez, M. Domenech, N. Jiménez, I. Victoria, S. López, M. Milà-Guasch, E. Felip, O. Etxaniz, J. Carles, F. Racca, N. Sala-González, A. González del Alba, P.L. Fernández, A. Prat, B. Mellado
Journal: Annals of Oncology (2017)
Melatonin Inhibits the Metastatic Ability of HER2/neu-negative Breast Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance
Authors: A. Tavartkiladze, G. Simonia, R. Khutsishvili
Journal: Annals of Oncology (2017)
Analysis of tumor PD-L1 expression and biomarkers in relation to clinical activity in patients (pts) with deficient DNA mismatch repair (dMMR)/high microsatellite instability (MSI-H) metastatic colorectal cancer (mCRC) treated with nivolumab (NIVO) + ipilimumab (IPI): CheckMate 142
Authors: T. André, M. Overman, S. Lonardi, M. Aglietta, R. McDermott, K.Y.M. Wong, M. Morse, A. Hendlisz, R.A. Moss, J.-M. Ledeine, H. Tang, Z.A. Cao, S. Kopetz
Journal: Annals of Oncology (2017)
Peptide receptor radionuclide therapy of neuroendocrine neoplasms using lutetium-177 and yttrium-90 labeled somatostatin analogs: A single center experience in over 1000 patients
Authors: A. Singh, H.R. Kulkarni, T. Langbein, C. Lehmann, K. Niepsch, D. Müller, M. Hommann, D. Kaemmerer, A. Jochems, P. Lambin, D. Hörsch, R.P. Baum
Journal: Annals of Oncology (2017)
Vigilancia de las infecciones humanas por Campylobacter en Francia- Primera Parte - ¿Qué datos? Estudio de los laboratorios microbiológicos, 2000
Authors: A Gallay, F Simon, F. Mégraud
Journal: Eurosurveillance (2003)

La frecuencia de las infecciones por Campylobacter en el hombre, su gravedad potencial y la existencia de medidas preventivas justifican la implantacion de un sistema de vigilancia de estas infecciones. Antes de implantarse el sistema de vigilancia, se realizo un estudio de las practicas diagnosticas de Campylobacter en los laboratorios. De los laboratorios que respondieron, casi todos analizaron Campylobacter al menos una vez en 1999. La identificacion de especies de Campylobacter se realizo en un 86% de los laboratorios hospitalarios y en un 37% de los laboratorios privados. El 75% y el 32% de ellos, respectivamente, realizaron pruebas de sensibilidad a los antibioticos. Muchos laboratorios analizan la presencia de Campylobacter en muestras de heces utilizando metodos comparables que demuestran la viabilidad de un sistema de vigilancia.
Clonality, Heterogeneity, and Evolution of Synchronous Bilateral Ovarian Cancer
Authors: Xia Yin, Ying Jing, Mei-Chun Cai, Pengfei Ma, Yi Zhang, Cong Xu, Meiying Zhang, Wen Di, Guanglei Zhuang
Journal: Cancer Research (2017)

Synchronous bilateral ovarian cancer (SBOC) represents a relatively frequent occurrence and clinically relevant diagnostic dilemma. Delineation of its clonal architecture, genetic heterogeneity, and evolutionary trajectories may have important implications for prognosis and management of patients with SBOC. Here, we describe the results of next-generation whole-exome or whole-genome sequencing of specimens from 12 SBOC cases and report that bilateral tumors from each individual display a comparable number of genomic abnormalities and similar mutational signatures of single-nucleotide variations. Clonality indices based on tumor-specific alterations supported monoclonal origins of SBOC. Each of the ovarian lesions was nevertheless oligoclonal, with inferred metastatic tumors harboring more subclones than their primary counterparts. The phylogenetic structure of SBOC indicated that most cancer cell dissemination occurred early, when the primary carcinoma was still relatively small (<100 million cells). Accordingly, the mutation spectra and mutational signatures of somatic variants exhibited pronounced spatiotemporal differences in each patient. Overall, these findings suggest that SBOCs are clonally related and form through pelvic spread rather than independent multifocal oncogenesis. Metastatic dissemination is often an early event, with dynamic mutational processes leading to divergent evolution and intratumor and intertumor heterogeneity, ultimately contributing substantially to phenotypic plasticity and diverse clinical course in SBOC. Cancer Res; 77(23); 6551-61. ©2017 AACR.
Circulating tumor cells as prognostic marker in ovarian carcinoma: Results from the ANTHALYA study
Authors: T. de La Motte Rouge, P. Cottu, P. Pautier, M. Provansal, A. Floquet, F. Selle, M. Fabbro, E. Kalbacher, P. Follana, A.F. Lesoin, J. Medioni, J. Dupin, R-M. Ferri, F-C. Bidard, C. Dubot, R. Rouzier, F. Joly Lobbedez
Journal: Annals of Oncology (2017)
Epidermal growth factor receptor (EGFR) copy number (CN) as a biomarker of prognosis and panitumumab (Pan) benefit in RAS-wt advanced colorectal cancer (aCRC)
Authors: J. Seligmann, H. Wood, S. Richman, F. Elliott, M. Taylor, E. Tinkler-Hundal, J. Barrett, M. Seymour, P. Quirke
Journal: Annals of Oncology (2017)
Signal, Uncertainty, and Conflict in Phylogenomic Data for a Diverse Lineage of Microbial Eukaryotes (Diatoms, Bacillariophyta)
Authors: Matthew B Parks, Norman J Wickett, Andrew J Alverson
Journal: Molecular Biology and Evolution (2017)

Diatoms (Bacillariophyta) are a species-rich group of eukaryotic microbes diverse in morphology, ecology, and metabolism. Previous reconstructions of the diatom phylogeny based on one or a few genes have resulted in inconsistent resolution or low support for critical nodes. We applied phylogenetic paralog pruning techniques to a data set of 94 diatom genomes and transcriptomes to infer perennially difficult species relationships, using concatenation and summary-coalescent methods to reconstruct species trees from data sets spanning a wide range of thresholds for taxon and column occupancy in gene alignments. Conflicts between gene and species trees decreased with both increasing taxon occupancy and bootstrap cutoffs applied to gene trees. Concordance between gene and species trees was lowest for short internodes and increased logarithmically with increasing edge length, suggesting that incomplete lineage sorting disproportionately affects species tree inference at short internodes, which are a common feature of the diatom phylogeny. Although species tree topologies were largely consistent across many data treatments, concatenation methods appeared to outperform summary-coalescent methods for sparse alignments. Our results underscore that approaches to species-tree inference based on few loci are likely to be misled by unrepresentative sampling of gene histories, particularly in lineages that may have diversified rapidly. In addition, phylogenomic studies of diatoms, and potentially other hyperdiverse groups, should maximize the number of gene trees with high taxon occupancy, though there is clearly a limit to how many of these genes will be available.
Multicenter prospective cohort study to evaluate of eye disorder induced by chemotherapy including S-1 (EyeDropS study/HGCSG1604)
Authors: M. Yagisawa, M. Nakamura, T. Muranaka, Y. Kawamoto, H. Nakatsumi, S. Yuki, T. Sasaki, T. Meguro, M. Dazai, A. Ishiguro, K. Eto, K. Harada, Y. Kobayashi, T. Miyagishima, I. Iwanaga, M. Uebayashi, K. Hatanaka, N. Sakamoto, Y. Sakata, Y. Komatsu
Journal: Annals of Oncology (2017)