tbuckley/cabot-search huggingface dataset:
Detección retrasada de un brote de shigelosis en un colegio de Madrid
Authors: J Jonsson, M C del Álvarez-Castillo, J C Sanz, R Ramiro, E Ballester, M Fernánez, A Echeíta, J. F. Martinez Navarro
Journal: Eurosurveillance (2005)

Aunque en Espana la shigelosis ha experimentado un marcado descenso, ocasionalmente se detectan brotes autoctonos. El objetivo de este estudio es describir un brote de shigelosis de transmision interpersonal ocasionado por Shigella sonnei en un colegio de Madrid. Ante la notificacion de un caso de infeccion por Shigella sonnei en una nina de 3 anos se inicio una investigacion en el centro escolar al que acudia. Se realizaron 520 encuestas epidemiologicas. Se definio como caso escolar si se trataba del primer caso ocurrido dentro de su nucleo familiar y como caso familiar a cualquier caso en un conviviente cuyo comienzo de sintomas fue posterior al del caso escolar. Se identificaron 88 casos (60 en alumnos y 28 entre sus familiares). La tasa de ataque (AR) en el colegio fue del 12% y del 32% en sus familias. Se observo una asociacion significativa entre mayor tasa de ataque y menor edad. El brote duro dos meses. La duracion del brote y la forma de la curva epidemica sugiere un patron de transmision interpersonal. El tipado mediante electroforesis en campo pulsado (PFGE) de cinco aislamientos de Shigella sonnei mostro una identidad comun de la cepa infectante. La prolongada duracion del brote esta relacionada probablemente con el retraso en la deteccion, y finalizo tan pronto como se introdujeron las medidas de control oportunas.
E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion
Authors: Boris Reidel, Giorgia Radicioni, Phillip W. Clapp, Amina A. Ford, Sabri Abdelwahab, Meghan E. Rebuli, Prashamsha Haridass, Neil E. Alexis, Ilona Jaspers, Mehmet Kesimer
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Rationale: E-cigarettes have become increasingly popular and little is known about their potential adverse health effects.Objectives: To determine the effects of e-cigarette use on the airways.Methods: Induced sputum samples from cigarette smokers, e-cigarette users, and nonsmokers were analyzed by quantitative proteomics, and the total and individual concentrations of mucins MUC5AC and MUC5B were determined by light scattering/refractometry and labeled mass spectrometry, respectively. Neutrophil extracellular trap (NET) formation rates were also determined for the same groups.Measurements and Main Results: E-cigarette users exhibited significant increases in aldehyde-detoxification and oxidative stress–related proteins associated with cigarette smoke compared with nonsmokers. The levels of innate defense proteins associated with chronic obstructive pulmonary disease, such as elastase and matrix metalloproteinase-9, were significantly elevated in e-cigarette users as well. E-cigarette users’ sputum also uniquely exhibited significant increases in neutrophil granulocyte–related and NET-related proteins, such as myeloperoxidase, azurocidin, and protein-arginine deiminase 4, despite no significant elevation in neutrophil cell counts. Peripheral neutrophils from e-cigarette users showed increased susceptibility to phorbol 12-myristate 13-acetate–induced NETosis. Finally, a compositional change in the gel-forming building blocks of airway mucus (i.e., an elevated concentration of mucin MUC5AC) was observed in both cigarette smokers and e-cigarette users.Conclusions: Together, our results indicate that e-cigarette use alters the profile of innate defense proteins in airway secretions, inducing similar and unique changes relative to cigarette smoking. These data challenge the concept that e-cigarettes are a healthier alternative to cigarettes.
Elucidation of Tumor-Promoting Effects of Novel Adherent Immature Myeloid Cells in Tumor
Authors: Takuya Tsubaki, Tetsuya Kadonosono, Tadashi Shiozawa, Takahiro Kuchimaru, Takashi Ushiki, Masayoshi Masuko, Shinae Kizaka-Kondoh
Journal: Blood (2016)
A simple algorithm for the identification of clinical COPD phenotypes
Authors: Pierre-Régis Burgel, Jean-Louis Paillasseur, Wim Janssens, Jacques Piquet, Gerben ter Riet, Judith Garcia-Aymerich, Borja Cosio, Per Bakke, Milo A. Puhan, Arnulf Langhammer, Inmaculada Alfageme, Pere Almagro, Julio Ancochea, Bartolome R. Celli, Ciro Casanova, Juan P. de-Torres, Marc Decramer, Andrés Echazarreta, Cristobal Esteban, Rosa Mar Gomez Punter, MeiLan K. Han, Ane Johannessen, Bernhard Kaiser, Bernd Lamprecht, Peter Lange, Linda Leivseth, Jose M. Marin, Francis Martin, Pablo Martinez-Camblor, Marc Miravitlles, Toru Oga, Ana Sofia Ramírez, Don D. Sin, Patricia Sobradillo, Juan J. Soler-Cataluña, Alice M. Turner, Francisco Javier Verdu Rivera, Joan B. Soriano, Nicolas Roche
Journal: European Respiratory Journal (2017)

This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 COPD patients of French/Belgian COPD cohorts were analysed using cluster analysis resulting in the identification of subgroups, for which clinical relevance was determined by comparing 3-year all-cause mortality. Classification and regression trees (CARTs) were used to develop an algorithm for allocating patients to these subgroups. This algorithm was tested in 3651 patients from the COPD Cohorts Collaborative International Assessment (3CIA) initiative. Cluster analysis identified five subgroups of COPD patients with different clinical characteristics (especially regarding severity of respiratory disease and the presence of cardiovascular comorbidities and diabetes). The CART-based algorithm indicated that the variables relevant for patient grouping differed markedly between patients with isolated respiratory disease (FEV 1 , dyspnoea grade) and those with multi-morbidity (dyspnoea grade, age, FEV 1 and body mass index). Application of this algorithm to the 3CIA cohorts confirmed that it identified subgroups of patients with different clinical characteristics, mortality rates (median, from 4% to 27%) and age at death (median, from 68 to 76 years). A simple algorithm, integrating respiratory characteristics and comorbidities, allowed the identification of clinically relevant COPD phenotypes.
Production of Tumors in Mice Following the Removal of Methylcholanthrene-Cholesterol Pellets
Authors: H. B. Andervont, M. J. Shear
Journal: JNCI Journal of the National Cancer Institute (1942)

Production of Tumors in Mice Following the Removal of Methylcholanthrene-Cholesterol Pellets Get access H. B. Andervont, H. B. Andervont principal biologist Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. Shear M. J. Shear principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 4, February 1942, Pages 333–334, https://doi.org/10.1093/jnci/2.4.333 Published: 01 February 1942
Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT
Authors: Srinivas R. Sadda, Robyn Guymer, Frank G. Holz, Steffen Schmitz-Valckenberg, Christine A. Curcio, Alan C. Bird, Barbara A. Blodi, Ferdinando Bottoni, Usha Chakravarthy, Emily Y. Chew, Karl Csaky, Ronald P. Danis, Monika Fleckenstein, K. Bailey Freund, Juan Grunwald, Carel B. Hoyng, Glenn J. Jaffe, Sandra Liakopoulos, Jordi M. Monés, Daniel Pauleikhoff, Philip J. Rosenfeld, David Sarraf, Richard F. Spaide, Ramin Tadayoni, Adnan Tufail, Sebastian Wolf, Giovanni Staurenghi
Journal: Ophthalmology (2017)
The role of liver biopsy in chronic hepatitis C
Authors: Jules L. Dienstag
Journal: Hepatology (2002)

The report of the 1997 National Institutes of Health Consensus Development Conference on hepatitis C endorsed pretreatment liver biopsy. We revisit the following questions: Does liver histology help determine the urgency of, and predict the likelihood of response to, antiviral therapy, and can surrogate markers supplant histological assessment? Because the rate of progression of chronic hepatitis C is influenced by baseline histological grade/stage, patients can be stratified into those with moderate to severe hepatitis, who merit imminent therapy, and those with mild hepatitis, in whom therapy can be postponed until more effective/tolerable treatments become available. Less advanced baseline histology has been shown to be an independent predictor of responsiveness to antiviral therapy. Although the predictive value of biopsy is insufficient to withhold therapy from patients with advanced fibrosis, baseline biopsy helps gauge expectations for the outcome of therapy. Reports have been published recently suggesting that laboratory markers can predict distinctions between low-grade fibrosis and therapy-indicating septal fibrosis/cirrhosis. These indices, however, are insufficiently reliable to predict histological distinctions in populations with varying prevalences of fibrosis/cirrhosis or to provide anything more than broad qualitative distinctions, far short of the potential information in a liver biopsy. For most patients, the value of pretreatment liver biopsy outweighs its risks, provides information about the urgency of treatment, and should be retained. Studies to identify noninvasive laboratory markers of histological activity and stage, especially genetic predictors of accelerated disease progression, command a high priority.
Decréscimo das taxas de marcadores virais, de 1990 a 1996, nos dadores de sangue não remunerados, na Europa
Authors: K Müller-Breitkreutz, T Evers, R Perry
Journal: Eurosurveillance (1998)

Apesar da aplicacao universal das tecnicas de inactivacao viral e de eliminacao dos virus durante a preparacao de produtos derivados de plasma (1,2), a exclusao de doacoes infectadas, antes de qualquer outro procedimento ou teste, continua a ser a etapa essencial a seguranca dos derivados do plasma e a principal determinante na seguranca dos componentes do sangue nao tratados.
Ten-year results of intense dose-dense chemotherapy show superior survival compared with a conventional schedule in high-risk primary breast cancer: final results of AGO phase III iddEPC trial
Authors: V. Möbus, C. Jackisch, H.J. Lück, A. du Bois, C. Thomssen, W. Kuhn, U. Nitz, A. Schneeweiss, J. Huober, N. Harbeck, G. von Minckwitz, I.B. Runnebaum, A. Hinke, G.E. Konecny, M. Untch, C. Kurbacher
Journal: Annals of Oncology (2017)
2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups
Authors: Ingrid E. Lundberg, Anna Tjärnlund, Matteo Bottai, Victoria P. Werth, Clarissa Pilkington, Marianne de Visser, Lars Alfredsson, Anthony A. Amato, Richard J. Barohn, Matthew H. Liang, Jasvinder A. Singh, Rohit Aggarwal, Snjolaug Arnardottir, Hector Chinoy, Robert G. Cooper, Katalin Dankó, Mazen M. Dimachkie, Brian M. Feldman, Ignacio Garcia‐De La Torre, Patrick Gordon, Taichi Hayashi, James D. Katz, Hitoshi Kohsaka, Peter A. Lachenbruch, Bianca A. Lang, Yuhui Li, Chester V. Oddis, Marzena Olesinska, Ann M. Reed, Lidia Rutkowska‐Sak, Helga Sanner, Albert Selva‐O'Callaghan, Yeong‐Wook Song, Jiri Vencovsky, Steven R. Ytterberg, Frederick W. Miller, Lisa G. Rider
Journal: Arthritis & Rheumatology (2017)

To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups.Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatology, neurology, and pediatric clinics worldwide. Several statistical methods were utilized to derive the classification criteria.Based on data from 976 IIM patients (74% adults; 26% children) and 624 non-IIM patients with mimicking conditions (82% adults; 18% children), new criteria were derived. Each item is assigned a weighted score. The total score corresponds to a probability of having IIM. Subclassification is performed using a classification tree. A probability cutoff of 55%, corresponding to a score of 5.5 (6.7 with muscle biopsy) "probable IIM," had best sensitivity/specificity (87%/82% without biopsies, 93%/88% with biopsies) and is recommended as a minimum to classify a patient as having IIM. A probability of ≥90%, corresponding to a score of ≥7.5 (≥8.7 with muscle biopsy), corresponds to "definite IIM." A probability of <50%, corresponding to a score of <5.3 (<6.5 with muscle biopsy), rules out IIM, leaving a probability of ≥50-<55% as "possible IIM."The European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology, and pediatric groups. They employ easily accessible and operationally defined elements, and have been partially validated. They allow classification of "definite," "probable," and "possible" IIM, in addition to the major subgroups of IIM, including juvenile IIM. They generally perform better than existing criteria.
TCT-99 Safety and Efficacy of Percutaneous Axillary Artery Access for Mechanical Circulatory Support with the Impella© Devices: An Initial Evaluation from the Axillary Access Registry to Monitor Safety (ARMS) MultiCenter Registry
Authors: James McCabe, Amir Khaki, William Nicholson, Nimrod Blank, J. Aaron Grantham, William Lombardi, Rajiv Tayal
Journal: Journal of the American College of Cardiology (2017)
TCT-410 Reendothelialization after SYNERGY stent and Bioresorbable Vascular Scaffold ABSORB implantation in Acute Myocardial Infarction : COVER-AMI Study
Authors: Thibault Lhermusier, Paul Ohayon, Nicolas Boudou, Francisco Campelo Parada, Frédéric Bouisset, Meyer Elbaz, Didier Carrié
Journal: Journal of the American College of Cardiology (2017)
L’épidémiologie de la syphilis infectieuse en République d’Irlande
Authors: M Cronin, L Domegan, L Thornton, M Fitzgerald, S Hopkins, P O’Lorcain, E Creamer, D O'Flanagan
Journal: Eurosurveillance (2004)

En reponse au nombre croissant de cas de syphilis rapportes chez des hommes ayant des relations sexuelles avec d’autres hommes (HSH) a Dublin, un groupe de controle des epidemies (Outbreak Control Team, OCT) s’est forme fin 2000. L’epidemie a atteint un pic en 2001 et s’est terminee vers la fin de 2003. Un systeme de surveillance approfondie de la syphilis a ete mis en place afin de recueillir les donnees a partir de janvier 2000. 
Entre janvier 2000 et decembre 2003, 547 cas de syphilis infectieuse ont ete declares en Irlande (dont 415 etaient des HSH). Dans les trois mois precedents, quatre pour cent des cas avaient ete contamines par le VIH et 15,4% par au moins une autre IST (en dehors du VIH). Le nombre median de relations declarees par les patients masculins dans les trois mois precedant le diagnostic etait de quatre (de 0 a 8) pour les relations heterosexuelles et de six pour les relations homosexuelles (de 1 a 90). Trente et un pour cent des HSH avaient eu recemment des relations orales non protegees et 15,9% des relations anales non protegees. Seize pour cent avaient eu des relations sexuelles a l’etranger dans les trois mois precedant le diagnostic. 
Les resultats suggerent que les comportements sexuels a risque ont contribue a prolonger la transmission de l’infection a Dublin. L’epidemie de Dublin peut etre consideree comme faisant partie d’une epidemie de syphilis a l’echelle europeenne. Les taux de co-infection par le VIH et la syphilis en Irlande sont comparables a ceux rapportes par d’autres centres. Il est necessaire d’ameliorer les systemes de surveillance pour pouvoir evaluer en temps reel les interventions et la surveillance en cours de l’evolution des infections.
TCT-473 Contrast-induced nephropathy (CIN) in patients with renal impairment: Pooled data from three prospective, randomized studies comparing iodixanol 320 mg and iopamidol 370mg
Authors: Cezar Staniloae, Lori Vales, Ningyan Shen, Cornelia Reininger
Journal: Journal of the American College of Cardiology (2017)
TCT-783 Comparison of Carbohydrate Antigen 125 and N-terminal Pro-Brain Natriuretic Peptide for Risk Prediction after Transcatheter Aortic Valve Implantation
Authors: Tobias Rheude, Costanza Pellegrini, Jonathan Michel, Teresa Trenkwalder, N. Patrick Mayr, Michael Joner, Markus Kasel, Stefan Holdenrieder, Julio Núñez Villota, Juan Sanchis Fores, Vicent Bodc, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
Journal: Journal of the American College of Cardiology (2017)
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development
Authors: Jun Li, Wenyan Han, Kenneth A. Pelkey, Jingjing Duan, Xia Mao, Ya-Xian Wang, Michael T. Craig, Lijin Dong, Ronald S. Petralia, Chris J. McBain, Wei Lu
Journal: Neuron (2017)
TCT-698 High post-procedural mitral valve gradients do not seem to influence long-term outcome in high-surgical risk patients treated by MitraClip implantation
Authors: Daniel Kalbacher, Eike Tigges, Florian Deuschl, Niklas Schofer, Johannes Schirmer, Lenard Conradi, Hermann Reichenspurner, Stefan Blankenberg, Edith Lubos
Journal: Journal of the American College of Cardiology (2017)
Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program
Authors: F. Cardoso, J.M.S. Bartlett, L. Slaets, C.H.M. van Deurzen, E. van Leeuwen-Stok, P. Porter, B. Linderholm, I. Hedenfalk, C. Schröder, J. Martens, J. Bayani, C. van Asperen, M. Murray, C. Hudis, L. Middleton, J. Vermeij, K. Punie, J. Fraser, M. Nowaczyk, I.T. Rubio, S. Aebi, C. Kelly, K.J. Ruddy, E. Winer, C. Nilsson, L. Dal Lago, L. Korde, K. Benstead, O. Bogler, T. Goulioti, A. Peric, S. Litière, K.C. Aalders, C. Poncet, K. Tryfonidis, S.H. Giordano
Journal: Annals of Oncology (2017)
Abstract 15385: Re-hospitalization Rates Following Stroke and Major Bleeding in Nonvalvular Atrial Fibrillation Patients
Authors: Gerald V Naccarelli, Michael Stokes, Rosa Wang, Anthony DeLeon, Natalie A Tate, Alan Wang, Jeremy R Fredell
Journal: Circulation (2014)

OBJECTIVES:  Although prior studies have documented re-hospitalization outcomes after stroke among patients with atrial fibrillation (AF), there are limited data regarding subsequent outcomes following major bleeding (MB). We sought to determine overall rates of hospitalizations for stroke and MB and to estimate re-hospitalization rates following each type of event in a real-world nonvalvular atrial fibrillation (NVAF) population.   METHODS:  A retrospective claims analysis of patients with NVAF enrolled in U.S commercial and Medicare health plans during 2008-2012 was performed. Thirty day and 1-year rates of all-cause, stroke related, and MB related re-hospitalizations were calculated separately for patients surviving a stroke and for those surviving MB. Overall rates were calculated by counting both initial and subsequent admissions. Re-hospitalization rates were calculated by counting all readmissions.   RESULTS:  Fifty-three percent of 40,654 patients included in the study received an anticoagulant. The overall rate of hospitalizations for major bleeding excluding intracranial hemorrhage (MBEIH) was higher compared to the overall rate of hospitalizations for stroke (13.4 vs. 9.3 per 100 PY) (TABLE). Among 5,512 patients with stroke, more than half (52%) were re-hospitalized during the first year after discharge. Among those with MB (n=8,452), 54% were re-hospitalized during the first year. Twenty-two percent of all-cause re-hospitalizations were related to stroke and 18% were related to MB during the first year following initial stroke. During the first year following first MB, 10% of all-cause re-hospitalizations were related to stroke and 25% were related to MB.   CONCLUSIONS:  Patients with NVAF face a significant risk of re-hospitalization following both stroke and MB events. Interventions preventing these events have the potential to reduce the large burden associated with re-hospitalization.
TCT-472 Predictive Value of the Age, Creatinine, and Ejection Fraction (ACEF) Score in Patients with Acute Coronary Syndromes
Authors: Barbara Stähli, Philipp Jakob, Roland Klingenberg, Slayman Obeid, Dik Heg, Lorenz Raber, Stephan Windecker, Baris Gencer, Ulf Landmesser, Christian Matter, Willibald Maier
Journal: Journal of the American College of Cardiology (2017)
Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics
Authors: Kelly G. Paulson, Song Youn Park, Natalie A. Vandeven, Kristina Lachance, Hannah Thomas, Aude G. Chapuis, Kelly L. Harms, John A. Thompson, Shailender Bhatia, Andreas Stang, Paul Nghiem
Journal: Journal of the American Academy of Dermatology (2017)
Multidisciplinary approach for preventing skeletal-related events in patients with bone metastasis
Authors: Shigeki Ito, Tomohiro Suzuki, Hisanori Ariga, Hideki Murakami, Yusuke Kimura, Hirooki Endo, Manabu Nakayama, Kazuyuki Ishida, Tamotsu Sugai, Shigeru Ehara
Journal: Annals of Oncology (2017)
Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence
Authors: Fernando J García López, María Ruiz-Tovar, Javier Almazán-Isla, Enrique Alcalde-Cabero, Miguel Calero, Jesús de Pedro-Cuesta
Journal: Eurosurveillance (2017)

Background: Sporadic Creutzfeldt–Jakob disease (sCJD) is potentially transmissible to humans. Objective: This study aimed to summarise and rate the quality of the evidence of the association between surgery and sCJD. Design and methods: Firstly, we conducted systematic reviews and meta-analyses of case–control studies with major surgical procedures as exposures under study. To assess quality of evidence, we used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Secondly, we conducted a systematic review of sCJD case reports after sharing neurosurgical instruments. Results: Thirteen case–control studies met the inclusion criteria for the systematic review of case–control studies. sCJD was positively associated with heart surgery, heart and vascular surgery and eye surgery, negatively associated with tonsillectomy and appendectomy, and not associated with neurosurgery or unspecified major surgery. The overall quality of evidence was rated as very low. A single case–control study with a low risk of bias found a strong association between surgery conducted more than 20 years before disease onset and sCJD. Seven cases were described as potentially transmitted by reused neurosurgical instruments. Conclusion: The association between surgery and sCJD remains uncertain. Measures currently recommended for preventing sCJD transmission should be strongly maintained. Future studies should focus on the potential association between sCJD and surgery undergone a long time previously.
TCT-300 Five-Year Major Clinical Outcomes between First-versus Second-Generation Drug-Eluting Stents in Coronary Chronic Total Occlusions: Propensity Score Matched Analysis
Authors: Yong Hoon Kim, Seung-Woon Rha, Ae-Young Her, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Won Young Jang, Woo Hyeun Kim, Eun Jin Park, Ja Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2017)