THE TREATMENT OF DIABETES MELLITUS WITH A FOUR-MEAL DIET: A MEANS OF CIRCUMVENTING CERTAIN DIFFICULTIES ARISING IN THE USE OF PROTAMINE ZINC INSULIN
Authors: H. M. Margolis, V. W. Eisenstein
Journal: Annals of Internal Medicine (1940)

Article1 October 1940THE TREATMENT OF DIABETES MELLITUS WITH A FOUR-MEAL DIET: A MEANS OF CIRCUMVENTING CERTAIN DIFFICULTIES ARISING IN THE USE OF PROTAMINE ZINC INSULINH. M. MARGOLIS, M.D., F.A.C.P., V. W. EISENSTEIN, M.D.H. M. MARGOLIS, M.D., F.A.C.P.Search for more papers by this author, V. W. EISENSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-4-667 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNew therapeutic agents, like new servants, are apt to present their best sides first, and only upon longer acquaintance reveal the disagreeable traits which hinder their usefulness. Despite technical refinements and improvements in the uniformity and stability of the new insulin products, which culminated in the development of protamine zinc insulin, frequent failings of the slower acting insulins have become apparent with extended experience. Briefly, these failings were manifest in diurnal glycosuria, in the necessity for supplementary injections of regular insulin, in serious, even fatal, reactions, and often, in fact, in such erratic diabetic control as to force the abandonment...References1. HAGEDORNJENSENKRARUPWODSTRUP HCBNBI: Protamine insulinate, Jr. Am. Med. Assoc., 1936, cvi, 177. CrossrefGoogle Scholar2. ROOTWHITEMARBLESTOTZ HFPAEH: Clinical experience with protamine insulinate, Jr. Am. Med. Assoc., 1936, cvi, 180. CrossrefGoogle Scholar3. SPRAGUEBLUMOSTERBERGKEPLERWILDER RGBBAEEJRM: Clinical observations with insulin protamine compounds, Jr. Am. Med Assoc., 1936, cvi, 1701. CrossrefGoogle Scholar4. ALLEN FM: Some difficulties arising in the use of protamine insulinate, Jr. Am. Med. Assoc., 1936, cvii, 430. CrossrefGoogle Scholar5. JOSLIN EP: Difficulties in the use of protamine zinc insulin, Jr. Am. Med. Assoc., 1938, cx, 90. CrossrefGoogle Scholar6. LAWRENCEARCHER RDN: Zinc protamine insulin, Brit. Med. Jr., 1937, i, 487. CrossrefGoogle Scholar7. KEPLER EJ: Clinical experience with protamine zinc insulin, Jr. Am. Med. Assoc., 1938, cx, 2. Google Scholar8. MOSENTHAL HO: Protamine zinc insulin, Jr. Am. Med. Assoc., 1938, cx, 88. Google Scholar9. DRYSDALE HR: Protamine insulin in juvenile diabetes, Jr. Am. Med. Assoc., 1937, cviii, 1250. CrossrefGoogle Scholar10. RALLIFEINLOVELOCK EPHDFJ: Observations on the continued use of protamine zinc insulin in patients with severe diabetes mellitus, Am. Jr. Med. Sci., 1938, cxcvi, 28. CrossrefGoogle Scholar11. BOYDJACKSON JDRL: Levels of control in the treatment of diabetes mellitus, Jr. Am. Med. Assoc., 1938, xi, 906. CrossrefGoogle Scholar12. EDITORIAL: Dangers of protamine insulin, Jr. Am. Med. Assoc., 1938, cxi, 254. Google Scholar13. SINDONI A: Protamine insulin versus ordinary insulin, Jr. Am. Med. Assoc., 1937, cviii, 1320. CrossrefGoogle Scholar14. JOSLIN EP: Protamine insulin, Jr. Am. Med. Assoc., 1937, cix, 497. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Received for publication April 27, 1939.From the Department of Metabolism, Montefiore Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Treatment of Diabetes 1 October 1940Volume 14, Issue 4Page: 667-687KeywordsDiabetes mellitusDietInsulinProtaminesZinc ePublished: 1 December 2008 Issue Published: 1 October 1940 PDF downloadLoading ...