tbuckley/cabot-search huggingface dataset:
Erratum. Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α <sup>1-67</sup> in Patients With Type 2 Diabetes. Diabetes Care 2017;40:1073–1081
Authors: Julie A. Lovshin, Harindra Rajasekeran, Yulyia Lytvyn, Leif E. Lovblom, Shajiha Khan, Robel Alemu, Amy Locke, Vesta Lai, Huaibing He, Lucinda Hittle, Weixun Wang, Daniel J. Drucker, David Z.I. Cherney
Journal: Diabetes Care (2017)

In the above-mentioned article, six asterisks were added to Fig. 2. In addition, the following information …
IVIVC開発に対する酢酸ロイプロリドを負荷したPLGAミクロスフェアの放出機構の特徴付け I in vitro評価
Authors: Hirota Keiji, C Doty Amy, Ackermann Rose, Zhou Jia, F Olsen Karl, R Feng Meihua, Wang Yan, Choi Stephanie, Qu Wen, S Schwendeman Anna, P Schwendeman Steven
Journal: Journal of Controlled Release (2016)
The 2017 EULAR standardised procedures for ultrasound imaging in rheumatology
Authors: Ingrid Möller, Iustina Janta, Marina Backhaus, Sarah Ohrndorf, David A Bong, Carlo Martinoli, Emilio Filippucci, Luca Maria Sconfienza, Lene Terslev, Nemanja Damjanov, Hilde Berner Hammer, Iwona Sudol-Szopinska, Walter Grassi, Peter Balint, George A W Bruyn, Maria Antonietta D’Agostino, Diana Hollander, Heidi J Siddle, Gabriela Supp, Wolfgang A Schmidt, Annamaria Iagnocco, Juhani Koski, David Kane, Daniela Fodor, Alessandra Bruns, Peter Mandl, Gurjit S Kaeley, Mihaela Micu, Carmen Ho, Violeta Vlad, Mario Chávez-López, Georgios Filippou, Carmen Elena Cerón, Rodina Nestorova, Maritza Quintero, Richard Wakefield, Loreto Carmona, Esperanza Naredo
Journal: Annals of the Rheumatic Diseases (2017)

In 2001, the European League Against Rheumatism developed and disseminated the first guidelines for musculoskeletal (MS) ultrasound (US) in rheumatology. Fifteen years later, the dramatic expansion of new data on MSUS in the literature coupled with technological developments in US imaging has necessitated an update of these guidelines.To update the existing MSUS guidelines in rheumatology as well as to extend their scope to other anatomic structures relevant for rheumatology.The project consisted of the following steps: (1) a systematic literature review of MSUS evaluable structures; (2) a Delphi survey among rheumatologist and radiologist experts in MSUS to select MS and non-MS anatomic structures evaluable by US that are relevant to rheumatology, to select abnormalities evaluable by US and to prioritise these pathologies for rheumatology and (3) a nominal group technique to achieve consensus on the US scanning procedures and to produce an electronic illustrated manual (ie, App of these procedures).Structures from nine MS and non-MS areas (ie, shoulder, elbow, wrist and hand, hip, knee, ankle and foot, peripheral nerves, salivary glands and vessels) were selected for MSUS in rheumatic and musculoskeletal diseases (RMD) and their detailed scanning procedures (ie, patient position, probe placement, scanning method and bony/other landmarks) were used to produce the App. In addition, US evaluable abnormalities present in RMD for each anatomic structure and their relevance for rheumatology were agreed on by the MSUS experts.This task force has produced a consensus-based comprehensive and practical framework on standardised procedures for MSUS imaging in rheumatology.
Sedentary lifestyle is putting middle aged health at risk, PHE warns
Authors: Gareth Iacobucci
Journal: BMJ (2017)

More than four in 10 adults in England aged 40-60—some 6.3 million—are putting their health at risk by not achieving 10 minutes of continuous brisk walking over the course of a month, warns a new evidence paper from Public Health England (PHE).

The summary paper,1 published on Thursday 24 August, assesses the published evidence on physical inactivity in England and concludes that 10 minutes of walking at a brisk intensity each day can help prevent cancer, heart disease, and poor mental health. …
Comparative efficacy and safety of reperfusion therapy with fibrinolytic agents in patients with ST-segment elevation myocardial infarction: a systematic review and network meta-analysis
Authors: Peerawat Jinatongthai, Junporn Kongwatcharapong, Chee Yoong Foo, Arintaya Phrommintikul, Surakit Nathisuwan, Ammarin Thakkinstian, Christopher M Reid, Nathorn Chaiyakunapruk
Journal: The Lancet (2017)
Hierarchy, multidomain modules, and the evolution of intelligence
Authors: Mauricio de Jesus Dias Martins, Laura Desirèe Di Paolo
Journal: Behavioral and Brain Sciences (2017)

Abstract In this commentary, we support a complex, mosaic, and multimodal approach to the evolution of intelligence. Using the arcuate fasciculus as an example of discontinuity in the evolution of neurobiological architectures, we argue that the strict dichotomy of modules versus G , adopted by Burkart et al. in the target article, is insufficient to interpret the available statistical and experimental evidence.
ゲノムワイド関連解析:非近交系マウスの複数の複雑形質について,超低カバー率塩基配列決定により行うゲノムワイド関連解析
Authors: Nicod Jerome, Davies Robert W, Cai Na, Goodstadt Leo, Bopp Nasrin, Bhomra Amarjit, Hernandez‐Pliego Polinka, Mott Richard, Flint Jonathan, Hassett Carl, Hough Tertius, Joynson Russell, Phelps Hayley, Nell Barbara, Rowe Clare, Wood Joe, Walling Alison, Harrison Mark, Fray Martin, Weaver Tom, Wells Sara, Cosgrove Cormac, Klenerman Paul, Yee Benjamin K, Lionikaite Vikte, Gregory Jennifer S, Aspden Richard M, Lionikas Arimantas, Mcintyre Rebecca E, Adams David J, Remme Carol Ann, Lodder Elisabeth M, Pinto Yigal M, Bezzina Connie R, Callebert Jacques, Launay Jean‐Marie, Talbot Nick P, Robbins Peter A, Blizard David A, Franken Paul, Brown Steve D M, Potter Paul K
Journal: Nature Genetics (2016)
STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4
Authors: Hui Wang, Xisong Huo, Xin-Rong Yang, Jia He, Lijun Cheng, Na Wang, Xuan Deng, Haojie Jin, Ning Wang, Cun Wang, Fangyu Zhao, Jingyuan Fang, Ming Yao, Jia Fan, Wenxin Qin
Journal: Molecular Cancer (2017)

Several of the thousands of human long noncoding RNAs (lncRNAs) have been functionally characterized, yet their potential involvement in hepatocellular carcinoma (HCC) remains poorly understood. LncRNA-HOXD-AS1 was identified by microarray and validated by real-time PCR. The clinicopathological significance of HOXD-AS1 was analyzed by Kaplan-Meier method. Chromatin immunoprecipitation was conducted to examine the mechanism of HOXD-AS1 upregulation. The role of HOXD-AS1 in HCC cells was assessed both in vitro and in vivo. ceRNA function of HOXD-AS1 was evaluated by RNA immunoprecipitation and biotin-coupled miRNA pull down assays. In this study, we found that HOXD-AS1 was significantly upregulated in HCC tissues. Clinical investigation demonstrated high expression level of HOXD-AS1 was associated with poor prognosis and high tumor node metastasis stage of HCC patients, and was an independent risk factor for survival. Moreover, our results revealed that STAT3 could specifically interact with the promoter of HOXD-AS1 and activate HOXD-AS1 transcription. Knockdown of HOXD-AS1 significantly inhibited migration and invasion of HCC cells in vitro and distant lung metastasis in vivo. Additionally, HOXD-AS1 was enriched in the cytoplasm, and shared miRNA response elements with SOX4. Overexpression of HOXD-AS1 competitively bound to miR-130a-3p that prevented SOX4 from miRNA-mediated degradation, thus activated the expression of EZH2 and MMP2 and facilitated HCC metastasis. In summary, HOXD-AS1 is a prognostic marker for HCC patients and it may play a pro-metastatic role in hepatocarcinogenesis.
Is “Do Everything!” Always Appropriate?—Reply
Authors: Tomasz M. Beer, Vinay Prasad
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Shared Decision Making and Improving Health Care
Authors: Victor M. Montori, Marleen Kunneman, Juan P. Brito
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OP0225 The effect of a low versus high first prescribed dose of methotrexate on eular response at six months using data from the rams study
Authors: R Davies, M Lunt, A Barton, KL Hyrich, SMM Verstappen
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Methotrexate (MTX) is one of the most commonly used drugs for the treatment of rheumatoid arthritis (RA). Recommendations by an international panel state that oral MTX should be started at 10–15mg/week, with escalation of 5mg every 2–4 weeks up to 20–30mg/week (1). In the UK, practice varies in terms of the starting dose prescribed for MTX, likely because of a lack of published evidence on the importance of MTX dose on its efficacy and safety. <h3>Objectives</h3> To compare 6 month response to MTX in RA patients starting 7.5mg/wk versus those starting a 15mg/wk. <h3>Methods</h3> Patients were recruited to the national, UK, multi-centre (n=35) longitudinal observational Rheumatoid Arthritis Medication Study (RAMS), including patients starting MTX for the first time with complete DAS28 at baseline and six months were included in this analysis. Patients were categorized into EULAR non-responders, moderate responders or good responders. Patients were categorised into those starting a low dose of MTX (≤7.5mg/wk) (LM-group) or a high dose of MTX (≥15mg/wk) (HM-group). A multinomial logistic regression model was used to test the association between MTX start dose and EULAR response at 6 months,with adjustments (see table) (relative risk ratio (RRR), 95% CI). The model was clustered by centre to account for the prescribing preferences of individual centres. <h3>Results</h3> 810 patients were included in this study: 171/810 (21%) starting low dose MTX and 639/810 (79%) starting high dose MTX. Patients in the HM-group had significantly lower physician and patient VAS scores and less functional disability compared to those in the LM-group (table). These patients were also less likely to be prescribed concomitant (nbDMARDs) (17% vs. 10%). DAS28 score at 6 months was significantly lower for patients in the HM-group. A fully adjusted multinomial logistic regression model, clustered by centre, showed that being in the high dose MTX group does not affect the odds of having a moderate response rather than no response, but does increase the odds of having a good response (RRR: 2.65 (95% CI 1.37, 5.14)). <h3>Conclusions</h3> Patients with RA starting MTX on a higher dose have increased odds of having a good EULAR response compared to non-response at 6 months. <h3>References</h3> Visser, K. et al (2009). Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative. Ann Rheum Dis, 68: 1086–1093. <h3>Disclosure of Interest</h3> None declared
Relationship between Abdominal Aortic Calcification and Geriatric Nutritional Risk Index in Chronic Kidney Disease Patients
Authors: Harada Kazuhiro, Suzuki Susumu, Hirayama Kenshi, Shibata Yohei, Harata Shingo, Kawashima Kazuhiro, Kunimura Ayako, Shinbo Yusaku, Takayama Yohei, Tatami Yosuke, Osugi Naohiro, Ota Tomoyuki, Kawamiya Toshiki, Yamamoto Dai, Ishii Hideki, Murohara Toyoaki
Journal: Circulation (2016)
An outbreak of Clostridium difficile infections due to new PCR ribotype 826: epidemiologic and microbiologic analyses
Authors: M.J.T. Crobach, A.F. Voor in 't holt, C.W. Knetsch, S.M. van Dorp, W. Bras, C. Harmanus, E.J. Kuijper, M.C. Vos
Journal: Clinical Microbiology and Infection (2017)

ObjectivesTo investigate an unusual outbreak of five patients with a total of eight episodes of a Clostridium difficile infection on a gastrointestinal surgical ward of a Dutch tertiary-care, university-affiliated hospital.MethodsClinical case investigations and laboratory analyses were performed. Laboratory analyses included PCR ribotyping, multiple-locus variable-number tandem repeat analysis typing, toxin typing, antimicrobial susceptibility testing and whole genome sequencing.ResultsThe outbreak was associated with recurrent and severe disease in two of five patients. All episodes were due to a unique ribotype that was not recognized in the collection of an international network of reference laboratories and was assigned PCR ribotype 826. PCR ribotype 826 is a toxin A–, toxin B– and binary toxin–positive ribotype which according to molecular typing belongs to clade 5 and resembles the so-called hypervirulent ribotype 078. The presence of a clonal outbreak was confirmed by whole genome sequencing, yet the source of this newly identified ribotype remained unclear.ConclusionsThis newly identified C. difficile PCR ribotype 826 is part of clade 5 and might also have increased virulence. The recognition of this outbreak highlights the need for ongoing C. difficile infection surveillance to monitor new circulating ribotypes with assumed increased virulence.
AB1051 Ultrasonography and power doppler ultrasonography of knee joint in patients with hepatitis c virus related arthritis
Authors: R Elgohary, A Khalil, G Ragab
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> HCV is a hepato-lymphotropic virus. Chronic arthritis is one of its extrahepatic manifestations<sup>1</sup>. The high frequency of rheumatoid factor (RF) positivity in HCV patients makes it difficult to differentiate between rheumatoid arthritis (RA) and HCV-related arthritis (HCVrA). An accurate and early diagnosis of HCVrA is important to avoid unnecessary immunosuppressive therapy<sup>2</sup>. Ultrasonography provides safe and quick access for the diagnosis of many rheumatic diseases. <h3>Objectives</h3> To illustrate ultrasonographic findings obtained in knee joints of patients with HCVrA &amp; to compare these findings with those obtained from knee joints of RA patients. <h3>Methods</h3> Fifteen patients with HCVrA &amp; 15 RA patients were subjected to: full history, clinical examination, Ultrasonography assessment using a Philips HDI 5000 system with 12–5 MHz Broadband Linear Transducer. Both knees were examined by one ultrasonographer who was blind to clinical data. <h3>Results</h3> In HCVrA, synovial hypertrophy was detected in 10% of knees (3/30) of which 66% (2 knees) exhibited Doppler signals, while in RA it was detected in 70% (21/30) of which 95% (20 knees) exhibited Doppler signals. Significant difference was found between the two groups (p&lt;0.01). Knee effusion was detected in 80% (24/30), &amp; 86% (26/30), of patients with HCVrA &amp; RA respectively, no significant difference was found. Cartilage degeneration was detected in 76% (23/30) &amp; 83% (25/30), of patients with HCVrA &amp; RA respectively. Bone erosions were detected in 20% (6/30) in the RA group. It was not detected in HCVrA patients. In HCVrA, there was no correlation between the presence of synovial hypertrophy with respect to cartilage degeneration and knee effusion. <h3>Conclusions</h3> We found no specific ultrasonographic feature specific for HCV related knee arthritis, the knee effusion is a predominant feature and the hypertrophied synovium is not frequently found. No destructive lesions were found to be related to the disease itself; however this should be confirmed by histopathological assessment. <h3>References</h3> Craxì Antonio, Laffi Giacomo &amp; Zignego Anna Linda. Hepatitis C virus (HCV) infection: A systemic disease. Molecular Aspects of Medicine 2008;29:85. Rosner Itzhak, Rozenbaum Michael, Toubi Elias, Kessel Aharon, Naschitz Jochanan, and Zuckerman Eli. The Case for Hepatitis C Arthritis, Seminars in Arthritis and Rheumatism 2004;33:377–379,381–382. <h3>Disclosure of Interest</h3> None declared
包膜化したhMSCsの分化による注入可能な組織再生システムへの応用のための温度応答性化学橋かけ可能なUV前処理したヒドロゲル【Powered by NICT】
Authors: Kim Young-Min, Potta Thrimoorthy, Park Keun-Hong, Song Soo-Chang
Journal: Biomaterials (2017)
Association of Comprehensive Lipoprotein Profiling with Coronary Artery Disease in Allogeneic Stem Cell Transplant (Allo-SCT) Survivors
Authors: Upneet Chawla, Maureen Sampson, Natasha A Jain, Prathima Anandi, Sawa Ito, Eleftheria Koklanaris, Pawel Muranski, John Barrett, Marcus Y Chen, Alan Remaley, Minoo Battiwalla
Journal: Blood (2016)
Chemotherapy of Neoplastic Disease
Authors: David A. Karnofsky
Journal: New England Journal of Medicine (1948)

IN RECENT years there has been a remarkable increase in research directed toward the discovery of chemical substances of therapeutic value in neoplastic disease. This endeavor has been stimulated by many factors: the intensification of medical research in general and cancer research in particular; the notable examples set by the development of antibiotics for bacterial infections; public demand for effective methods of controlling the disease; and the ever-present, suffering, doomed, but often lingering, patient with cancer. Recent chemotherapeutic advances — estrogens in prostatic carcinoma, nitrogen mustards in the lymphomas and urethane in the leukemias — have provided some encouragement toward . . .
The Role of Hyperglycemia, Insulin Resistance, and Blood Pressure in Diabetes-Associated Differences in Cognitive Performance—The Maastricht Study
Authors: Stefan L.C. Geijselaers, Simone J.S. Sep, Danny Claessens, Miranda T. Schram, Martin P.J. van Boxtel, Ronald M.A. Henry, Frans R.J. Verhey, Abraham A. Kroon, Pieter C. Dagnelie, Casper G. Schalkwijk, Carla J.H. van der Kallen, Geert Jan Biessels, Coen D.A. Stehouwer
Journal: Diabetes Care (2017)

OBJECTIVE To study to what extent differences in cognitive performance between individuals with different glucose metabolism status are potentially attributable to hyperglycemia, insulin resistance, and blood pressure–related variables. RESEARCH DESIGN AND METHODS We used cross-sectional data from 2,531 participants from the Maastricht Study (mean age ± SD, 60 ± 8 years; 52% men; n = 666 with type 2 diabetes), all of whom completed a neuropsychological test battery. Hyperglycemia was assessed by a composite index of fasting glucose, postload glucose, glycated hemoglobin (HbA1c), and tissue advanced glycation end products; insulin resistance by the HOMA of insulin resistance index; and blood pressure–related variables included 24-h ambulatory pressures, their weighted SDs, and the use of antihypertensive medication. Linear regression analyses were used to estimate mediating effects. RESULTS After adjustment for age, sex, and education, individuals with type 2 diabetes, compared with those with normal glucose metabolism, performed worse in all cognitive domains (mean differences in composite z scores for memory −0.087, processing speed −0.196, executive function and attention −0.182; P values &amp;lt;0.032), whereas individuals with prediabetes did not. Diabetes-associated differences in processing speed and executive function and attention were largely explained by hyperglycemia (mediating effect 79.6% [bootstrapped 95% CI 36.6; 123.4] and 50.3% [0.6; 101.2], respectively) and, for processing speed, to a lesser extent by blood pressure–related variables (17.7% [5.6; 30.1]), but not by insulin resistance. None of the factors explained the differences in memory function. CONCLUSIONS Our cross-sectional data suggest that early glycemic and blood pressure control, perhaps even in the prediabetic stage, may be promising therapeutic targets for the prevention of diabetes-associated decrements in cognitive performance.
Is “Do Everything!” Always Appropriate?
Authors: Aroop Mangalik
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
マイクロピラーに及ぼす細胞内細胞幾何学は幹細胞分化を調節する【Powered by NICT】
Authors: Liu Xiangnan, Liu Ruili, Cao Bin, Ye Kai, Li Shiyu, Gu Yexin, Pan Zhen, Ding Jiandong
Journal: Biomaterials (2016)
マルチモダリティ癌診断のためのナノ粒子:ガドリニウムイオンにより媒介された金ナノクラスタの自己集合のための簡単なプロトコル【Powered by NICT】
Authors: Hou Wenxiu, Xia Fangfang, Alfranca Gabriel, Yan Hao, Zhi Xiao, Liu Yanlei, Peng Chen, Zhang Chunlei, de la Fuente Jesus Martinez, Cui Daxiang
Journal: Biomaterials (2017)
Exercise Therapy is More Effective for Coronary Plaque Stabilization in Diabetes Mellitus Patients
Authors: Noto Takahisa, Oshitani Koichi, Harada Daisuke, Takagawa Junya, Ishise Hisanari, Kameyama Tomoki, Asanoi Hidetsugu, Inoue Hiroshi
Journal: Circulation (2016)