tbuckley/cabot-search huggingface dataset:
Estudio de la contaminación de alimentos de origen animal por Escherichia coli serotipo O157:H7 productor de shigatoxina. Bélgica ,1999-2003
Authors: A Chahed, Y Ghafir, B China, K Dierick, L De Zutter, D Piérard, G Daube
Journal: Eurosurveillance (2005)

Entre 1999 y 2003 se realizo en Belgica un estudio sobre la prevalencia de Escherichia coli (STEC) serotipo O157 productor de shigatoxina en productos alimenticios de origen animal (vaca, ternero, pollo, pescado). Las cepas de STEC solo fueron aisladas en la carne de vaca, con una prevalencia del 0,73%. Se trata de una prevalencia baja comparada con otros paises. Entre las 76 cepas de STEC O157 aisladas, el 75% pertenecian al serotipo O157:H7 y el 25% al serotipo O157 no H7. Ademas, el patotipo mas frecuente fue el eae stx2 ehxA (74%).
Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress
Authors: Carla Nasca, Benedetta Bigio, Danielle Zelli, Paolo de Angelis, Timothy Lau, Masahiro Okamoto, Hideyo Soya, Jason Ni, Lars Brichta, Paul Greengard, Rachael L. Neve, Francis S. Lee, Bruce S. McEwen
Journal: Neuron (2017)
Efficacy and safety of necitumumab and pembrolizumab combination therapy in patients with stage IV non-small cell lung cancer (NSCLC)
Authors: B. Besse, P. Garrido Lopez, J. Puente, A. Cortot, M.E. Olmedo Garcia, M. Perol, M. Gil, G. Chao, J. Shahidi, J. Bennouna
Journal: Annals of Oncology (2017)
FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
Authors: Tian Lan, Donald A. Morgan, Kamal Rahmouni, Junichiro Sonoda, Xiaorong Fu, Shawn C. Burgess, William L. Holland, Steven A. Kliewer, David J. Mangelsdorf
Journal: Cell Metabolism (2017)
Abstract 15962: Sensitivity and Specificity of High Sensitive Cardiac Troponin T for Predicting Stable Ischemic Heart Disease and its Severity in 4608 Japanese High-Risk Participants
Authors: Masahiro Hirose, Satoshi Hoshide, Tomokazu Ikemoto, Yukihiro Hojo, Takaaki Katsuki, Kazuomi Kario
Journal: Circulation (2012)

Introduction  Detectable levels of cardiac troponin T (cTnT) have become increasingly more sensitive.Recently, the highly sensitive assay for cTnT (hs-cTnT) has been developed. However,it is unclear whether its levels were useful in Japanese, because Japanese population differ the event rate of ischemic heart disease (IHD) compared with Western population. We investigated whether there is an association between the level of hs-cTnT and angiographic severity of coronary artery disease and whether this association is independent of conventional risk factors and other biomarkers. Design,Method, and Patients Patients with stable and asymptomatic IHD performed percutaneous coronary intervention (CAD group:n=1359, age 64.3±9.8y.o., male 83.7%) and outpatients with one or more conventional coronary risk factors without past history of IHD and heart failure (Control group: n=3249, age 64.7±10.7y.o., male 43.9%) were divided into quintiles of hs-cTnT levels.  Results The odds ratio of incidence of IHD increased from the lowest hs-cTnT quintile to the highest. . From ROC analysis, sensitibity of hs-cTnT to determine CAD patients was 82.9% and its specificity was 62.6% (cut off value; hsTnT>0.0045ng/ml). When we identify cut-off at 0.003ng/ml (undetectable limit) and 0.015ng/ml (standard detection limit), their sensitivity and specificity of IHD were 90.4%, 49.5% and 28.5%, 93.6%, respectively. There is a close association between hs-cTnT level and severerity of coronary arteries confirmed by the number of narrows coronary arteries. Conclusion Hs-cTnT is a useful biomarker for predicting IHD in Japanese patients who were at high risk for cardiovascular disease high risk Japanese as well as Western population, and it was associated with the severity of coronary arteries.CAD.
Registry Data as an “Alert” System for Detection of Occupational Lung Cancer Risk: Reply
Authors: Roy E. Albert, M.D., Peter Greenwald, M.D.
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Registry Data as an “Alert” System for Detection of Occupational Lung Cancer Risk: Reply Get access Roy E. Albert, M.D., Roy E. Albert, M.D. Institute of Environmental Medicine New York University Medical Center, 550 First Avenue, New York, New York 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter Greenwald, M.D. Peter Greenwald, M.D. Division of Epidemiology New York State Department of Health Empire State Plaza, Albany, New York 12237 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 65, Issue 3, September 1980, Page 496, https://doi.org/10.1093/jnci/65.3.496 Published: 01 September 1980
NHS staff march against passport checks
Authors: Zosia Kmietowicz
Journal: BMJ (2017)

Claudia Moroni

Healthcare professionals and supporters took to the streets in London, Manchester, and Newcastle on 30 September to raise awareness about the charges being introduced in the NHS, often for the most vulnerable patients, such as refugees.

The marchers converged on St Thomas’s Hospital, near Westminster, where they were invited to share their stories of patients being asked for identification or being denied care.

The protest was organised by the group Docs Not Cops (#patientsnotpassports) in collaboration …
A Big Sister society?
Authors: Fiona Godlee
Journal: BMJ (2017)

When you imagine a surgeon, is that person white and male? The online campaign #ILookLikeASurgeon aims to tackle this stereotype, which campaigners say discourages women and ethnic minorities from entering and flourishing in surgery. The campaign has gained traction, but change of this sort takes time.

Research published in this week’s journal might help. Wallis and colleagues look at whether surgeons’ sex affected how patients fared after surgery (doi:10.1136/bmj.j4366). They found that, in a wide range of common procedures, patients treated by female surgeons …
The differences in recurrence and survival of extremity liposarcoma subtypes
Authors: M. Vos, H. Kosela Paterczyk, P. Rutkowski, G.J.L.H. van Leenders, M. Normantowicz, A. Lecyk, S. Sleijfer, K. Verhoef, D.J. Grünhagen
Journal: Annals of Oncology (2017)
First line cetuximab and cisplatin with or without paclitaxel in recurrent/metastatic head and neck cancer: A randomized phase IIb trial
Authors: P. Bossi, L.H. Hollander, R. Miceli, D. Ferrari, S. Vecchio, G. Moretti, M. Merlano, F. Caponigro, C. Moro, E. Vaccher, O. Alabisio, A. Caldara, A. Russo, F. Ferrau, F. Nolè, L. Licitra
Journal: Annals of Oncology (2017)
Due focolai di trichinellosi nella regione della Rhine-Westfalia settentrionale, Germania, 1998
Authors: S Rehmet, G Sinn, O Robstad, H David, D Lesser, K Nöckler, G Scherholz, D Erkrath, D Pechmann, L R Petersen, R Kundt, G Oltmans, R Lange, J Laumen, U Nogay, M Dixius, J Eichenberg, F Dinse, D Stegemann, W Lotz, D Franke, P Hag, A Ammon
Journal: Eurosurveillance (1999)

In Germania, l'infezione o il decesso conseguenti a trichinellosi devono essere notificati obbligatoriamente. Dal 1987 al 1997, ogni anno, sono stati notificati tra zero e dieci casi. Tuttavia, dal Novembre 1998 al Gennaio 1999, 52 casi di trichinellosi sono stati identificati dai sistemi di sorveglianza di sanita pubblica in 11 citta e distretti di una regione tedesca, la Rhine-Westfalia settentrionale. Questo rapporto riassume l'indagine condotta, che ha indicato come si siano verificate due epidemie contemporanee: una provocata da carne macinata contaminata e l'altra da salsicce crude affumicate prodotte industrialmente (Mettwurst). Le informazioni sulla trichinellosi, le sue cause e modalita di trasmissione sono state trattate in un recente numero speciale di Eurosurveillance (1).
Coronary flow reserve is predictive of the risk of cardiovascular death regardless of chronic kidney disease stage
Authors: David M. Charytan, Hicham Skali, Nishant R. Shah, Vikas Veeranna, Michael K. Cheezum, Viviany R. Taqueti, Takashi Kato, Courtney R. Bibbo, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Marcelo F. Di Carli
Journal: Kidney International (2017)
Medical costs and health care resource use (HCRU) in elderly us patients (pts) with newly diagnosed metastatic or surgically unresectable urothelial carcinoma (mUC) using surveillance, epidemiology, and end results (SEER) medicare data
Authors: A. Aly, C. Johnson, S. Yang, S. Rao, M. Botteman, A. Hussain
Journal: Annals of Oncology (2017)
ESR1, Ph-mTOR, CDK4/6 and PD-L1 expression as prognostic (and potentially druggable) drivers for pure invasive lobular breast carcinoma (ILC): Preliminary results of prognostic outliers according to a clinical-pathological model
Authors: L. Carbognin, M. Brunelli, E. Manfrin, A. Caliò, I. Sperduti, M.V. Dieci, G. Griguolo, V. Guarneri, R. Nortilli, S. Pilotto, E. Fiorio, V. Parolin, E. Orvieto, F. Pellini, G.P. Pollini, P.F. Conte, A. Scarpa, G. Tortora, E. Bria
Journal: Annals of Oncology (2017)
Risk of Tinnitus After Medial Temporal Lobe Surgery
Authors: Sébastien Paquette, Philippe Fournier, Sophie Dupont, Fabien Szabo de Edelenyi, Pilar Galan, Séverine Samson
Journal: JAMA Neurology (2017)

This study compares the prevalence of tinnitus among patients who underwent medial temporal lobe resection, matched controls, and individuals with self-reported epilepsy to determine whether medial temporal lobe removal is associated with tinnitus.
Modifiable factors associated with patient-reported pain during and after screening colonoscopy
Authors: Marek Bugajski, Paulina Wieszczy, Geir Hoff, Maciej Rupinski, Jaroslaw Regula, Michal Filip Kaminski
Journal: Gut (2017)

Objective Pain associated with colonoscopy is a major burden for patients. We investigated modifiable factors associated with patient-reported pain during and after colonoscopy. Design This cross-sectional analysis included database records from 23 centres participating in a population-based colonoscopy screening programme in Poland. Colonoscopies were performed under three sedation modalities: none, benzodiazepine-opioid sedation or propofol sedation. We used Gastronet (a validated tool) to assess patients’ pain during and after colonoscopy; pain was scored on a four-point scale (no, little, moderate or severe pain), with moderate to severe defined as painful. We used multivariate logistic regression models to estimate ORs for painful colonoscopy and calculated risk-adjusted ratios of painful colonoscopies per endoscopist and compared it to the mean rate. Results Of 35 216 screening colonoscopies in 2014 and 2015 included in our study, 22 725 (64.5%) patients returned valid Gastronet questionnaires. The proportion of examinations described as causing pain during (after) the procedure was 22.5% (14.2%) for unsedated, 19.9% (13.5%) for benzodiazepine-opioid sedation and 2.5% (7.5%) for propofol sedation. Propofol sedation, higher case volume of endoscopists, newest endoscope generation and adequate bowel preparation were significantly associated with lower odds of painful colonoscopy. Pain scores after colonoscopy showed similar associations. Adjusted pain rates during and after colonoscopy varied 11 and over 23-fold, respectively, between endoscopists. Conclusion We identified several independent, modifiable factors associated with pain during and after colonoscopy, of which individual endoscopist was the most important. Dedicated training should be considered to decrease variability among endoscopists.
Phase II study of modified docetaxel, cisplatin and S-1 (mDCS) combination chemotherapy in patients with unresectable metastatic gastric cancer
Authors: Y. Sato, H. Ohnuma, K. Okamoto, H. Miyamoto, M. Hirakawa, N. Uemura, S. Kikuchi, T. Sagawa, K. Fujikawa, Y. Takahashi, S. Minami, T. Okuda, M. Takahashi, J. Kato, T. Takayama
Journal: Annals of Oncology (2017)
Comparison of the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) in clinical trials supporting US Food and Drug Administration (FDA) approval of orphan vs. non-orphan drugs
Authors: C. Molto Valiente, A. Tibau, A. Ocana Fernandez, A. Templeton, L. del Carpio Huerta, J. Del Paggio, A. Barnadas, C. Booth, E. Amir
Journal: Annals of Oncology (2017)
A estratégia da Comunidade europeia contra a resistência antimicrobiana
Authors: S Bronzwaer, A Lönnroth, R Haigh
Journal: Eurosurveillance (2004)

Em 2001, a Comissao europeia apresentou a Estrategia comunitaria contra a resistencia  Em anos anteriores este problema foi abordado atraves de um numero crescente de medidas isoladas., mas nesta estrategia a Comunidade Europeia, atraves da Comissao, delineou uma abordagem compreensiva do problema abrangendo todos os sectores. Esta estrategia consiste em quinze accoes em quatro areas chave: vigilância, prevencao, pesquisa e desenvolvimento de produtos, e cooperacao internacional. Uma parte importante desta estrategia e contituida pelas Recomendacoes do Conselho sobre o uso prudente de agentes antimicrobianos em medicina humana. Esta recomendacao apresenta um conjunto detalhado de accoes de saude publica para o controlo da resistencia antimicrobiana. Este artigo apresenta os onze pontos de accao desta estrategia que estao directamente relacionados com a medicina humana, assim como as actividades da Comunidade europeia relacionadas com este assunto. A resistencia antimicrobiana e uma prioridade-chave no programa de pesquisa da Uniao Europeia bem como do seu novo programa de Saude Publica.
Shortage or Surplus of Physicians in the United States
Authors: Jerry Kruse
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Programa Europeo de Formación en Epidemiología de Intervención
Authors: A Moren, Mike Rowland, F van Loock, J Giesecke
Journal: Eurosurveillance (1996)

El Programa Europeo de Formacion en Epidemiologia de Intervencion (EPIET) proporciona una experiencia practica en epidemiologia de las enfermedades infecciosas. El EPIET pretende crear una red de profesionales distribuidos por toda Europa cuyo objetivo es utilizar un enfoque estandar en la epidemiologia de intervencion, incluido el trabajo de campo, la vigilancia, la investigacion aplicada, la comunicacion y el uso de informacion epidemiologica como base para la adopcion de medidas sanitarias. La financiacion del EPIET procede de una beca otorgada por la Direccion General V de la Comision de las Comunidades Europeas.
Randomized phase 2 trial of peri- or post-operative chemotherapy in resectable pancreatic adenocarcinoma
Authors: M. Reni, S. Zanon, G. Balzano, R. Castoldi, A. Zerbi, M.C. Tronconi, D. Pinelli, S. Mosconi, C. Doglioni, F. Galli, M. Falconi, L. Gianni
Journal: Annals of Oncology (2017)
Is There a ‘Right to Try’ Experimental Therapies? Ethical Criteria for Selecting Patients With Spinal Muscular Atrophy to Receive Nusinersen in an Expanded Access Program
Authors: Nancy S. Jecker
Journal: The American Journal of Bioethics (2017)

"Is There a ‘Right to Try’ Experimental Therapies? Ethical Criteria for Selecting Patients With Spinal Muscular Atrophy to Receive Nusinersen in an Expanded Access Program." The American Journal of Bioethics, 17(10), pp. 70–71
Misdirections in Informed Consent — Impediments to Health Care Innovation
Authors: David A. Asch, Tracy A. Ziolek, Shivan J. Mehta
Journal: New England Journal of Medicine (2017)

Interview with Dr. David Asch on why requiring informed consent for trials that pose minimal risk to participants can do more harm than good. (10:20)Download Many ethicists analyzing the Common Rule are more forgiving than IRBs of waivers of informed consent in low-risk studies. Several sources of misdirection in defining "adverse effects on rights and welfare" create unnecessary obstacles to quality-improvement efforts.
Authors reply: Importance of standardisation of HAI definitions in interpretation of international and/or multinational prevalence studies
Authors: M J Veldman-Ariesen, R Eilers
Journal: Eurosurveillance (2012)

Preview this article: Authors reply: Importance of standardisation of HAI definitions in interpretation of international and/or multinational prevalence studies, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/37/art20270-en-1.gif
Abiraterone acetate (AA) + prednisolone (P) for metastatic castration-resistant prostate cancer (mCRPC) with early progression or non-response to androgen deprivation therapy (ADT)
Authors: G. Arai, M. Ogi, K. Kobayashi, N. Okuno, T. Takahara, K. Fukushima, K. Yoshizawa
Journal: Annals of Oncology (2017)
GPs indemnity to be provided through state backed scheme, says Hunt
Authors: Abi Rimmer
Journal: BMJ (2017)

GPs will have access to a state backed indemnity scheme from 2019, the health secretary Jeremy Hunt has announced.

Speaking at the Royal College of General Practitioners’ (RCGP) annual conference in Liverpool on Thursday, Hunt said that the Department of Health would create a state backed scheme for clinical negligence indemnity for general practice in England.

The announcement comes after repeated warnings from the RCGP, the BMA, and defence unions that indemnity costs were spiralling and risked creating a crisis in general practice.1

Hunt said, “I know a big issue has been the fluctuations, variability, and the cost of indemnity, and we’ve seen that rise to around £8000 per GP. We need to introduce a state backed indemnity scheme for general practice.”

“It will take us 18 months to negotiate with …
The oral microbiota in colorectal cancer is distinctive and predictive
Authors: Burkhardt Flemer, Ryan D Warren, Maurice P Barrett, Katryna Cisek, Anubhav Das, Ian B Jeffery, Eimear Hurley, Micheal O‘Riordain, Fergus Shanahan, Paul W O‘Toole
Journal: Gut (2017)

Background and aims Microbiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally derived, if such cases are a distinct subset of patients or if the oral microbiome is generally suitable for screening for CRC. Methods We profiled the microbiota in oral swabs, colonic mucosae and stool from individuals with CRC (99 subjects), colorectal polyps (32) or controls (103). Results Several oral taxa were differentially abundant in CRC compared with controls, for example, Streptococcus and Prevotella s pp. A classification model of oral swab microbiota distinguished individuals with CRC or polyps from controls (sensitivity: 53% (CRC)/67% (polyps); specificity: 96%). Combining the data from faecal microbiota and oral swab microbiota increased the sensitivity of this model to 76% (CRC)/88% (polyps). We detected similar bacterial networks in colonic microbiota and oral microbiota datasets comprising putative oral biofilm forming bacteria. While these taxa were more abundant in CRC, core networks between pathogenic, CRC-associated oral bacteria such as Peptostreptococcus , Parvimonas and Fusobacterium were also detected in healthy controls. High abundance of Lachnospiraceae was negatively associated with the colonisation of colonic tissue with oral-like bacterial networks suggesting a protective role for certain microbiota types against CRC, possibly by conferring colonisation resistance to CRC-associated oral taxa and possibly mediated through habitual diet. Conclusion The heterogeneity of CRC may relate to microbiota types that either predispose or provide resistance to the disease, and profiling the oral microbiome may offer an alternative screen for detecting CRC.
Factors predicting the outcome in febrile neutropenia: A study from a tertiary cancer center in India.
Authors: Krishnamani Kalpathi, Sadashivudu Gundeti, Rajesh Kota, Muralidhar Gullipalli, Vijay Gandhi Linga, Raghunadharao Digumarti
Journal: Journal of Clinical Oncology (2013)

e20684 Background: Febrile neutropenia (FN) is common in patients undergoing chemotherapy. The risk dramatically increases in those with absolute neutrophil count (ANC) less than 100/ mm 3 . Methods: In this 2 year studyall FN patients admitted at our center between January 2011 and November 2012 were analyzed for clinical profile, microbiologic isolates, mortality and factors affecting outcome. IBM statistic SPSS version 19 was used to analyze the data. Results: There were 333 episodes of FN during the study period. Majority (89.7%) of FN episodes occurred in patients with hematologic malignancies and 87% of episodes had ANC&lt; 500. Induction, consolidation and maintenance related episodes were 125 (37.5%), 125 (37.5%) and 17 (5.1%) respectively. First line antibiotics (cefipime, Cefaperazone- Sulbactum + aminoglycoside), second line antibiotics (carbapenam) and antifungals were used in 44.4%, 15.6 % and 34% episodes respectively. Gram negative organisms accounted for 51.6% of the isolates. Prognostic significance between mean serum bilirubin, serum creatinine and outcome was noted, with higher deaths in patients with bilirubin &gt; 1.5 mg% (12.2% vs 0.7%) (p= 0.000) and creatinine &gt; 1.2 mg% (16% vs 1%) (p=0.000). Isolation of an organism and infiltrates on chest X-ray had a significant association with outcome(p= 0.017 and 0.002) respectively. Patients who had multiple component transfusions vs single component ones were at a significantly higher risk of death ( 6 deaths vs 1)(p= 0.002). There were 20 (6%) possible,33 (10%) probable and 9 (2.7 %) proven fungal infections, with significant association with outcome (p=0.000). The risk of death in those with fungal infection was 14.323 (95%CI - 2.70-75.952). Preemptiveantifungal use had a higher percentage of prolonged (&gt; 8 days) and profound neutropenia in contrast to the empirical group (77.2% vs 65.2%) and (91% vs 83.8%), resulting in 3 deaths in the preemptive group (6.8% vs 0%) (p=0.02). The overall mortality was 2.1%. Conclusions: Leukemias are the leading cause of FN at our Institute with 2.1% mortality. Higher bilirubin, creatinine, chest imaging favoring pneumonia, positive isolates and multiple transfusions had significant association with mortality.
Efficacy of olaparib maintenance therapy in patients (pts) with platinum-sensitive relapsed ovarian cancer (PSROC) by lines of prior chemotherapy: Phase III SOLO2 trial (ENGOT Ov-21)
Authors: R. Penson, M-C. Kaminsky-Forrett, J. Ledermann, C. Brown, M. Plante, J. Korach, T. Huzarski, A. Gomez de Liano Lista, C. Pisano, M. Friedlander, N. Colombo, M. Gropp-Meier, H. Nakai, G.S. Sonke, J-W. Kim, I. Vergote, A. Allen, E. Pujade-Lauraine
Journal: Annals of Oncology (2017)