tbuckley/cabot-search huggingface dataset:
Acute promyelocytic leukemia and chronic lymphocytic leukemia diagnosed concurrently
Authors: Catherine C. Coombs, Stephanie P. Mathews
Journal: American Journal of Hematology (2017)

A 57-year-old male with history of type 2 diabetes presented with 2 weeks of malaise and hyperglycemia. Complete blood counts were notable for a newly elevated WBC count of 58.3 × 109/L with 62% abnormal promyelocytes and 16% lymphocytes, hemoglobin of 11.2 g/dL, and platelet count of 60 ×109/L (Image 1, panel A, original magnification ×1000, Wright–Giemsa stain). Coagulation testing demonstrated evidence of mild disseminated intravascular coagulation. He was placed on all-trans retinoic acid (ATRA) and hemostatic support while awaiting definitive diagnosis. Peripheral blood flow cytometry confirmed an abnormal CD13+, CD33+, CD64+, CD117+, CD71partial+, CD34+ myeloid population with aberrant CD2 and CD56 expression. Evaluation of the lymphocyte fraction identified a concurrent monotypic B-cell population with the classic immunophenotype of chronic lymphocytic leukemia (CLL) (CD5+, CD19+, CD20dim+, CD23+). The absolute number of clonal B-cells in the peripheral blood was 9400/μL. Karyotype revealed t(15;17) and FISH testing demonstrated PML-RARA translocation in addition to a low-level 13q deletion. Bone marrow biopsy demonstrated concurrent microgranular acute promyelocytic leukemia (APL) and CLL (Image 1, panels B-F; panel B, original magnification ×400, Wright–Giemsa stain; panel C, original magnification ×400; panel D, original magnification ×400, CD117; panel E, original magnification ×400, Pax-5; panel F, original magnification ×400, CD5). The patient was induced with idarubicin/ATRA/arsenic as per APML4 protocol.1 Histopathologic findings of concurrent microgranular APL and CLL. A. Peripheral blood smear showed circulating mature-appearing lymphocytes and abnormal promyelocytes (Wright-Giemsa; 1000×). B–F. Bone marrow biopsy demonstrated presence of both microgranular APL and CLL. Panel B: Wright-Giemsa at 400×; Panel C: Hematoxylin and eosin at 400×; Panel D: CD117 at 400×; Panel E: Pax-5 at 400×; and Panel F: CD5 at 400×. Microgranular APL lack characteristic Auer rods and can pose a diagnostic challenge by morphologic assessment alone. Diagnosis is aided by cytogenetics and flow cytometry with characteristic co-expression of CD2 and CD34.2 Concurrent diagnoses of APL and CLL to our knowledge has not been previously reported, though a case of concomitant CLL and APL with suspected pre-existing CLL3 and new APL in patients with known CLL have been reported.4, 5 In our case, expeditious diagnosis and emergent treatment of high-risk APL led to a complete remission of the APL (though with residual CLL). Honoraria from H3 Biomedicine and Pharmacyclics (Coombs) - though neither related to this work.
Hydrochlorothiazide Is Superior to Isradipine for Reduction of Left Ventricular Mass: Results of a Multicenter Trial
Authors: Vasilios Papademetriou, John S. Gottdiener, Puneet Narayan, William G. Cushman, Prince K. Zachariah, Patricia S. Gottdiener, Gary A. Chase
Journal: Journal of the American College of Cardiology (1997)

Objectives. We sought to determine the efficacy of isradipine in reducing left ventricular (LV) mass and wall thickness in hypertensive patients. Background. LV hypertrophy on the echocardiogram is a strong predictor of cardiovascular events. Reduction of LV mass may be a desirable goal of drug therapy for hypertension. However, although thiazide diuretic drugs have been advocated as first-line therapy for hypertension, their efficacy in reducing LV mass has been questioned. Methods. Patients with mild to moderate diastolic hypertension and LV mass in excess of 1 SD of normal values were randomized to isradipine (n = 89) or hydrochlorothiazide therapy (n = 45). Evaluations were obtained at baseline, after 3 and 6 months of treatment and 2 weeks after treatment was stopped. Results. At 6 months, LV mass decreased by 43 ± 45 g (mean ± SD) with hydrochlorothiazide (p < 0.001) but only by 11 ± 48 g with isradipine (p = NS; between-group comparison, p < 0.001). Two weeks after drug therapy was stopped, LV mass remained 24 ± 41 g lower than that at baseline in the hydrochlorothiazide group (p = 0.003) but only 7 ± 50 g lower in the isradipine group (p = NS). Septal and posterior wall thicknesses were significantly and equally reduced with both isradipine and hydrochlorothiazide. Greater LV mass reduction with hydrochlorothiazide was related to a 2.8 ± 3.3-mm reduction of LV cavity size with hydrochlorothiazide but no reduction with isradipine. At 6 months of treatment, diastolic blood pressure (BP) by design was equally reduced in both treatment groups. At 3 months, systolic BP was reduced by 17 ± 15 mm Hg with isradipine and by 26 ± 15 and 25 ± 17 mm Hg at 3 and 6 months, respectively, with hydrochlorothiazide (p = 0.003, between-group comparison). However, on stepwise multivariable regression analysis, treatment selection (partial r2= 0.082, p = 0.001), change in average 24-h systolic BP (partial r2= 0.032, p = 0.029) and change in average sitting systolic BP (partial r2= 0.017, p = 0.096) were predictive of LV mass reduction. Conclusions. Despite an equivalent reduction of diastolic BP, 6 months of therapy with hydrochlorothiazide is associated with a substantial reduction of LV mass, greater than that with isradipine. The superior efficacy of hydrochlorothiazide for LV mass reduction is associated with a greater reduction of systolic BP as well as drug selection itself. These data may have important therapeutic implications.
Multiphoton microscopy: A novel diagnostic method for solid tumors in a prospective pediatric oncologic cohort, an experimental study
Authors: Oliver J. Muensterer, Sibylle Waldron, Yoon Jung Boo, Claudius Ries, Lisa Sehls, Frank Simon, Larissa Seidmann, Jérôme Birkenstock, Jan Gödeke
Journal: International Journal of Surgery (2017)
The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases
Authors: Annika Sommer, Beate Winner, Iryna Prots
Journal: Molecular Neurodegeneration (2017)

Neuronal degeneration is a common mechanism of many neurological diseases including Parkinson’s disease (PD), Alzheimer’s disease (AD), and Multiple Sclerosis (MS). While AD and PD are classical neurodegenerative diseases, the primary pathology in MS is driven by autoimmune inflammation, attacking oligodendrocytes and thereby inducing neurodegeneration. In AD and PD, immune cells are also considered to play an important role in the disease progression. While the role of local central nervous system (CNS) innate immune cells is well described, a potential influence of adaptive immune cells in PD and AD is not yet fully understood. Here, we aim to summarize findings concerning adaptive immune cells in PD pathogenesis and compare them to AD and MS. In the first part, we focus on disease-specific alterations of lymphocytes in the circulating blood. Subsequently, we describe what is known about CNS-infiltrated lymphocytes and mechanisms of their infiltration. Finally, we summarize published data and try to understand the mechanisms of how lymphocytes contribute to neurodegeneration in PD, AD, and MS. Lymphocytes are critically involved in the pathogenesis of MS, and clarifying the role of lymphocytes in PD and AD pathogenesis might lead to an identification of a common signature of lymphocytes in neurodegeneration and thus pave the road towards novel treatment options.
The ClosER study: results from a three-year pan-European longitudinal surveillance of antibiotic resistance among prevalent Clostridium difficile ribotypes, 2011–2014
Authors: J. Freeman, J. Vernon, S. Pilling, K. Morris, S. Nicholson, S. Shearman, C. Longshaw, M.H. Wilcox
Journal: Clinical Microbiology and Infection (2017)
TCT-690 Percutaneous left atrial appendage closure with complex anatomy by using the staged double “kissing-Watchman” technology
Authors: Jiangtao Yu, Lisheng Jiang, Manuela Muenzel, Xin Xue, Zhihua Wang, Adam Fasakas, Thorsten Keil, Erich Duenninger
Journal: Journal of the American College of Cardiology (2017)
An Effort of the cooperation between medical and dental service for the perioperative mouth care in our hospital
Authors: Tatsushi Kato, Ritsuko Sata, Syogo Kito, Yuya Nakamura, Hiroyuki Nakayama, Shigenori Kanazawa, Kazuyuki Yamaguchi, Ryuji Okamura
Journal: Annals of Oncology (2017)
Trump signs executive orders in bid to undermine Obamacare
Authors: Owen Dyer
Journal: BMJ (2017)

US doctors’ groups have condemned a series of executive orders signed by President Donald Trump aimed at undermining the Affordable Care Act (“Obamacare”), which they said would bring “dramatic, if not catastrophic, increases in premiums across the country.”1

Frustrated after the Senate voted three times against repealing Obamacare, Trump signed an order on 12 October to increase access to association health plans, a class of insurance not bound by Obamacare’s rules on coverage. These plans typically offer patchier coverage at lower premiums and are expected to lure younger, healthier customers away from the Obamacare exchanges, forcing insurers on those exchanges to cope with older, sicker risk pools that will drive up premiums. …
Hypermetabolic Vocal Cord Focus With Recurrent Oral Cancer History
Authors: Michael U. Antonucci, Ross M. Hansen, Terry A. Day
Journal: JAMA Oncology (2017)

A woman in her 80s with a history of recurrent oral cancer was diagnosed with squamous cell carcinoma located at the margin of a palatal graft; surveillance imaging reveals metabolic activity in her left vocal cord. What is your diagnosis?
Preparación hospitalaria y manejo de los pacientes con fiebre hemorrágica vírica o con viruela en el Instituto Lazzaro Spallanzani, Roma, Italia
Authors: G Ippolito, E Nicastri, M R Capobianchi, A Di Caro, N Petrosillo, V Puro
Journal: Eurosurveillance (2005)

Los casos americanos de carbunco en 2001 y el brote reciente de sindrome respiratorio agudo grave o severo (SRAS) pusieron de manifiesto la necesidad de una preparacion y respuesta a las infecciones emergentes o re-emergentes de forma natural y a los agentes patogenos diseminados deliberadamente. El presente informe describe el modelo de respuesta del Instituto nacional para las enfermedades infecciosas (INMI, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Roma, Italia) para el manejo de pacientes infectados – o sospechosos de serlo – por la viruela o la fiebre hemorragica, sea en el contexto de una emision deliberada del virus o de una infeccion ocurrida de forma natural. 
En Italia, el INMI es el hospital de referencia en cuanto a planes de preparacion y de respuesta a los agentes infecciosos relacionados con ataques bioterroristas. Todas las habitaciones, simples o dobles, estan equipadas con presion negativa del aire, puertas reforzadas, filtros HEPA (high efficiency particulate air), asi como una antecamara completamente equipada. Ademas se dispone de una unidad de alta seguridad, con un laboratorio anexo para las primeras pruebas de diagnostico, destinada a los casos esporadicos que necesiten aislamiento. Para el trasporte de los pacientes, el instituto dispone de dos ambulancias totalmente equipadas y de dos camillas aisladas con una seccion de presion negativa. Las pruebas diagnosticas moleculares y tradicionales se realizan actualmente en los laboratorios de bioseguridad de nivel 3/4. La educacion y formacion del personal hospitalario, la aplicacion estricta de las practicas de control de la infeccion y disponer de equipos de proteccion personal, son recursos adicionales que permiten manejar a los pacientes extremadamente contagiosos, y mantener un equipo correctamente preparado para responder frente a brotes de gran escala.
Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents
Authors: Andrea L. Casillas, Rachel K. Toth, Alva G. Sainz, Neha Singh, Ankit A. Desai, Andrew S. Kraft, Noel A. Warfel
Journal: Clinical Cancer Research (2017)

Purpose: Patients develop resistance to antiangiogenic drugs, secondary to changes in the tumor microenvironment, including hypoxia. PIM kinases are prosurvival kinases and their expression increases in hypoxia. The goal of this study was to determine whether targeting hypoxia-induced PIM kinase expression is effective in combination with VEGF-targeting agents. The rationale for this therapeutic approach is based on the fact that antiangiogenic drugs can make tumors hypoxic, and thus more sensitive to PIM inhibitors.Experimental Design: Xenograft and orthotopic models of prostate and colon cancer were used to assess the effect of PIM activation on the efficacy of VEGF-targeting agents. IHC and in vivo imaging were used to analyze angiogenesis, apoptosis, proliferation, and metastasis. Biochemical studies were performed to characterize the novel signaling pathway linking PIM and HIF1.Results: PIM was upregulated following treatment with anti-VEGF therapies, and PIM1 overexpression reduced the ability of these drugs to disrupt vasculature and block tumor growth. PIM inhibitors reduced HIF1 activity, opposing the shift to a pro-angiogenic gene signature associated with hypoxia. Combined inhibition of PIM and VEGF produced a synergistic antitumor response characterized by decreased proliferation, reduced tumor vasculature, and decreased metastasis.Conclusions: This study describes PIM kinase expression as a novel mechanism of resistance to antiangiogenic agents. Our data provide justification for combining PIM and VEGF inhibitors to treat solid tumors. The unique ability of PIM inhibitors to concomitantly target HIF1 and selectively kill hypoxic tumor cells addresses two major components of tumor progression and therapeutic resistance. Clin Cancer Res; 24(1); 169-80. ©2017 AACR.
TCT-260 Safety and Effectiveness of XIENCE Stents in Chronic Total Occlusion Revascularization: Long-Term Results from the EXPERT CTO Multicenter Clinical Trial
Authors: David Kandzari, Annapoorna Kini, Dimitri Karmpaliotis, Jeffrey Moses, Pradyumna Tummala, J. Aaron Grantham, William Lombardi, William Nicholson, Nicholas Lembo
Journal: Journal of the American College of Cardiology (2017)
TCT-330 Multi-Center Evaluation of a Novel 120 μm Novolimus-Eluting, Fully Bioresorbable Coronary Scaffold: First Report of 6-month Imaging and 12-Month Clinical Results
Authors: Alexandre Abizaid, Mathias Vrolix, J. Ribamar Costa, Daniel Chamie, Andrea Abizaid, Juliana Castro, Vinayak Bhat, Lynn Morrison, Sara Toyloy, Stefan Verheye
Journal: Journal of the American College of Cardiology (2017)
Early Human Herpes Virus 6 Infection after Autologous Stem Cell Transplantation: A Multicenter Prospective Observational Study of 196 Patients (VIRAUTO 6)
Authors: Marie Balsat, Sylvie Pillet, Mathieu Oriol, Emmanuelle Tavernier, Victoria Cacheux, Vanessa Escuret, Cecile Molucon-Chabrot, Karine Augeul-Meunier, Audrey Mirand, Christel Regagnon, Fabien Tinquaut, Denis Guyotat, Gilles A. Salles, Jacques-Olivier Bay, Jerome Cornillon
Journal: Blood (2016)
The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses
Authors: Liangshun You, Liping Mao, Juying Wei, Shenhe Jin, Chunmei Yang, Hui Liu, Li Zhu, Wenbin Qian
Journal: Journal of Hematology & Oncology (2017)

T cells recognize antigen fragments from proteolytic products that are presented to them in the form of peptides on major histocompatibility complex (MHC) molecules, which is crucial for the T cell to identify infected or transformed cells. Autophagy, a process that delivers cytoplasmic constituents for lysosomal degradation, has been observed to provide a substantial source of intra- and extracellular antigens for MHC presentation to T cells, which will impact the tumor-specific immune response. Meanwhile, extracellular components are transported to cytoplasm for the degradation/secretion process by the endo-/exosomal pathway and are thus involved in multiple physiological and pathological processes, including immune responses. Autophagy and endo-/exosomal pathways are intertwined in a highly intricate manner and both are closely involved in antigen processing for MHC presentation; thus, we propose that they may coordinate in antigen processing and presentation in anticancer T cell immune responses. In this article, we discuss the molecular and functional crosstalk between autophagy and endo-/exosomal pathways and their contributions to antigen processing for MHC presentation in anticancer T cell immune responses.
Syphilis et gonorrhée en République Tchèque
Authors: H Zákoucká, V Polanecký, V Kaštánková
Journal: Eurosurveillance (2004)

La syphilis est encore un probleme de sante publique en Republique Tcheque, comme partout dans le monde. La Republique Tcheque, qui appartenait a la Tchequoslovaquie jusqu’en 1993, a une longue tradition en sante publique, et la surveillance des IST est principalement axee sur les infections connues comme “maladies veneriennes” : la syphilis, la gonorrhee, le chancre mou et le lymphogranulome venerien. Les campagnes de prevention depuis le debut des annees 1950 ont reussi a controler la syphilis et la gonorrhee ; le chancre mou et le lymphogranulome venerien sont des infections extremement rares. A la fin des annees 1980, on notait une faible incidence de cas de syphilis nouvellement declares (100 a 200 cas annuels), cependant que 6500 cas de gonorrhee environ etaient enregistres annuellement a la meme periode. En Republique Tcheque, les soins de sante et la prevention des IST se basent sur une etroite cooperation entre les services cliniques et les services microbiologiques et epidemiologiques des Bureaux de sante environnementale. Des statistiques annuelles sur les donnees de cas declares de “maladies veneriennes”, sur la base des codes ICD-10, sont disponibles depuis 1959. Les donnees statistiques sur d’autres IST ne sont pas disponibles separement, seules les donnees aggregees d’infections a Chlamydia trachomatis ont ete presentees chaque annee depuis 2000 [5]. 
A la suite des changements politiques et sociaux qu’a vecu la communaute Tcheque en 1989, une augmentation de la syphilis est apparue nettement. Cinquante a 60% des cas notifies ont ete classes comme latents tardifs ou d’une duree inconnue. La persistance de cas de syphilis congenitale (7 a 18 cas par an) pendant les annees 1990 est aussi un phenomene a ne pas negliger. Les cas etaient concentres dans de vastes zones urbaines avec un niveau important de prostitution. Une forte proportion de cas est egalement identifiee chez les refugies. Alors que l’incidence annuelle de la gonorrhee a baisse progressivement de 1994 a 2001 (de 28,5 a 8,9 pour 100 000), l’incidence de la syphilis a augmente pendant la meme periode de 3,6 a 9,6 pour 100 000 (avec un pic de 13,4 en 2001), pour depasser l’incidence de la gonorrhee en 2000, pour la premiere fois depuis des annees.
Breathing new life into an old target: pulmonary disease drugs for Parkinson’s disease therapy
Authors: Hisham Abdelmotilib, Andrew B. West
Journal: Genome Medicine (2017)

Increases in α-synuclein protein expression are suspected to increase the risk of the development of Parkinson's disease (PD). A recent study has demonstrated that β2-adrenergic receptor (β2AR) agonists decrease histone acetylation in the α-synuclein gene and suppress transcription. Coupled with the anti-inflammatory effects that are associated with β2AR activation, this two-pronged attack holds promise for PD treatment and the development of new therapeutic approaches for this disease.
Abstract 273: T cell Sphingosine 1-Phosphate Receptor 1 Signaling Possesses Intrinsic Anti-fibrotic Effects in Murine Heart
Authors: Zhuqiu Jin, Chowdhury S Abdullah
Journal: Circulation Research (2016)

T lymphocyte infiltration into myocardium has been observed in patients with myocardial infarction and diabetic cardiomyopathy. T cell trafficking from primary lymphoid organs into blood depends on S1P receptor 1 (S1P 1 ) activation and S1P concentration gradients. However, effects of T cell S1P 1 signaling activation on cardiac fibrosis and function remain unknown. Mice with conditional knockout of T cell S1P 1 were generated by cross-bred of S1P 1 loxp-loxp mice with Lck-Cre transgenic mice. T cell S1P 1 mutant mice (TS1P 1 KO) and wildtype littermate (WT) were utilized. To explore the effect of T cell S1P 1 on cardiac fibrosis and myocardial function, additional groups with reconstitution of T cells containing S1P 1 were conducted by injection of freshly prepared T cells from WT into TS1P 1 KO. Body weight, glucose levels, and behavior change were recorded twice a week. After 11 weeks, Langendorff heart perfusion was prepared. Cardiac contractile force was recorded. Trichrome staining was used to evaluate the extent of cardiac fibrosis. CD4, CD8, and Foxp3 regulatory T cells in the blood and spleen were quantified with flow cytometry. Expression of TGF-beta and CD34 in mouse myocardium was determined by using immunohistochemistry. Comparing with WT control, TS1P 1 KO mice exerted increased cardiac fibrosis and low cardiac contractile force (P&lt;0.05). TGF-beta expression and CD34 stained cells were significantly enhanced in TS1P 1 KO mice. Both CD4 and CD8 T cells in the blood and spleen were reduced significantly in TS1P 1 KO. Reconstitution of T cells with S1P 1 into TS1P1KO attenuated cardiac fibrosis and myocardial dysfunction. In conclusion, T cell S1P 1 signaling plays a critical role in anti-fibrosis and cardioprotection.
Bichat recommandations sur la prise en charge clinique des patients présentant une encéphalite virale lors d'un acte de bioterrorisme
Authors: P Bossi, A Tegnell, A Baka, F van Loock, A Werner, J Hendriks, H Maidhof, G Gouvras
Journal: Eurosurveillance (2004)

La majorite des virus responsables d’encephalite sont transmis par des arthropodes, a l’exception des arenavirus transmis par des rongeurs. En depit de l’absence de connaissances suffisantes, il apparait que la plupart des virus responsables d’encephalite, et surtout les alphavirus, pourraient etre utilises par aerosolisation comme arme biologique. Une autre facon d’utiliser ces virus comme arme, serait d’infecter et de repandre des vecteurs comme des moustiques ou des tiques. La presentation clinique de l’ensemble de ces virus n’est pas specifique, mais les techniques de biologie moleculaire permettent d’en faire plus facilement le diagnostic. Il n’existe pas de traitement specifique de ces infections ; le traitement repose essentiellement en une bonne prise en charge en unite de soins intensifs. Pour certains de ces virus, il existe un vaccin.
Forte diversité du traitement de la tuberculose en Finlande
Authors: T Vasankari, M Kokki, P Holmström, K Liippo, S Sarna, P Ruutu
Journal: Eurosurveillance (2007)

Nous avons etudie les traitements administres et l’issue du traitement sur une cohorte nationale de cas de tuberculose pulmonaire confirmes par culture en Finlande. Notre objectif etait de mesurer l’adequation du traitement antituberculeux prescrit et l’issue du traitement. Les dossiers medicaux de tous les cas de tuberculose pulmonaire confirmes par culture de 1995 a 1996 ont ete pris en compte pour evaluer le traitement et l’issue du traitement, en se basant sur les recommandations europeennes pour le suivi du traitement.