Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study
Authors: Duncan Wilson, Gareth Ambler, Clare Shakeshaft, Martin M Brown, Andreas Charidimou, Rustam Al-Shahi Salman, Gregory Y H Lip, Hannah Cohen, Gargi Banerjee, Henry Houlden, Mark J White, Tarek A Yousry, Kirsty Harkness, Enrico Flossmann, Nigel Smyth, Louise J Shaw, Elizabeth Warburton, Keith W Muir, Hans Rolf Jäger, David J Werring, John Aeron-Thomas, Prasanna Aghoram, Elaine Amis, Peter Anderton, Sreeman Andole, Ijaz Anwar, John Bamford, Azra Banaras, Aian Barry, Ruth Bellfied, Aienne Benford, Ajay Bhalla, Maneesh Bhargava, Biju Bhaskaran, Neelima Bhupathiraju, Jonathan Birns, Aian Blight, Angie Bowring, Ellen Brown, David Bruce, Amanda Buck, Kerry Bunworth, Ilse Burger, Laura Burgess, Mathew Burn, Evelyn Burssens, Mauian Burton, Nicola Butler, Denise Button, Michael Carpenter, Dinesh Chadha, Kausik Chatterjee, Lillian Choy, David Cohen, Lynne Connell, Martin Cooper, John Corrigan, Donna Cotterill, Gillian Courtauld, Susan Crawford, Claire Cullen, Krishna Dani, Amelia Daniel, Prabel Datta, Michelle Davis, Nicola Day, Mandy Doherty, Catherine Douglas, Karen Dunne, Collette Edwards, Charlotte Eglinton, Abduelbaset Elmarimi, Hedley Emsley, Timothy England, Daniel Epstein, Renuka Erande, Bernard Esisi, Rachel Evans, Pamela Farren, Pauline Fitzell, Glyn Fletcher, Rachel Gallifent, Rachel Gascoyne, Elio Giallombardo, Bindu Gregary, Gunaratam Gunathilagan, Paul Guyler, Brigid Hairsine, Michael Haley, Anne Hardwick, David Hargroves, Frances Harrington, Amanda Hedstrom, Clare Holmes, Senussi Hussein, Tanya Ingram, Sissi Ispoglou, Liz Iveson, Venetia Johnson, Frances Justin, Shahid Kausar, Karen Kee, Michael Keeling, Shagufta Khan, Agnieszka Kieliszkowska, Hayley Kingwell, Vinodh Krishnamurthy, Sagal Kullane, Balakrishna Kumar, Simon Leach, Sana Leason, Paula Lopez, Robert Luder, Barbara Madigan, Stuart Maguire, Holly Maguire, Karim Mahawish, Linetty Makawa, Maam Mamun, Dulka Manawadu, David Mangion, Aravindakshan Manoj, Syed Mansoor, Tracy Marsden, Rachel Marsh, Sheila Mashate, Michael McCormick, Clare McGolick, Madeleine McKee, Emma Mckenzie, Sanjeevikumar Meenakishundaram, Zoe Mellor, Amulya Misra, Amit Mistri, Azlisham Mohd Nor, Mushiya Mpelembue, Peter Murphy, Arumug Nallasivam, Ann Needle, Vinh Nguyen, Janice O'Connell, Paul O'Mahony, James Okwera, Chukwuka Orefo, Peter Owusu-Agyei, Anthea Parry, Adrian Parry-Jones, Kath Pasco, Chris Patterson, Cassilda Peixoto, Jane Perez, Nicola Persad, Mia Porteous, Michael Power, Christopher Price, Harald Proschel, Shuja Punekar, Janet Putterill, Marc Randall, Ozlem Redjep, Habib Rehman, Emma Richards, Victoria Riddell, Christine Roffe, Gill Rogers, Anthony Rudd, Kari Saastamoinen, Mahmud Sajid, Banher Sandhu, Christine Schofield, Jon Scott, Lakshmanan Sekaran, Pankaj Sharma, Jagdish Sharma, Simon Sharpe, Matthew Smith, Anew Smith, Nikola Sprigg, Julie Staals, Amy Steele, Gail Storey, Kelley Storey, Santhosh Subramonian, Jane Sword, Grainne Tallon, Garryck Tan, Margaret Tate, Jennifer Teke, Natalie Temple, Teresa Thompson, Sharon Tysoe, Djamil Vahidassr, Anouk van der Kwaak, Roland Veltkamp, Deborah Walstow, Caroline Watchurst, Fran Watson, Dean Waugh, Peter Wilkinson, David Wilson, Sarah Wilson-Owen, Belinda Wroath, Inez Wynter, Emma Young
Journal: The Lancet Neurology (2018)

Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that are prone to intracranial bleeding. We aimed to determine whether presence of cerebral microbleeds can identify patients at high risk of symptomatic intracranial haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient ischaemic attack.