tbuckley/cabot-search huggingface dataset:
DEVELOPMENT AND VALIDATION OF PREDICTION MODELS WITH NON-TRADITIONAL MARKERS FOR 10-YEAR RISK OF ISCHEMIC LEG AMPUTATION AMONG PERSONS WITH DIABETES: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
Authors: Kunihiro Matsushita, Shoshana H. Ballew, Corey Kalbaugh, Bethany Warren, Laura Loehr, Anna Kucharska-Newton, Ron Hoogeveen, Christie Ballantyne, Gerardo Heiss, Aaron Folsom, Alan Hirsch, Josef Coresh, Elizabeth Selvin
Journal: Journal of the American College of Cardiology (2017)
The Addition of Novel Agents to Front-Line Therapy Significantly Improve the Short-Term and Long-Term Therapeutic Effects of High Risk Waldenstrom's Macroglobulinemia Patients in China
Authors: Wenjie Xiong, Shuhua Yi, Heng Li, Zengjun Li, Rui Lv, Wei Liu, Yan Xu, Dehui Zou, Mu Hao, Lugui Qiu
Journal: Blood (2016)
Comprehensive genomic profiling of 443 patients with advanced renal cell carcinoma (RCC) to reveal clinically relevant genomic alterations and to aid in classification of rare subtypes.
Authors: Yuankai Shi, Hongnan Mo, Xuezhi Hao, Yutao Liu, Lin Wang, Xingsheng Hu, Jianping Xu, Sheng Yang, Pu-Yuan Xing, Youwu Shi, Bo Jia, Yan Wang, Li Junling, Hongyu Wang, Ziping Wang, Yan Sun
Journal: Journal of Clinical Oncology (2015)

e19048 Background: Poor prognosis of advanced NSCLC patients and the promising therapeutic effect of platinum urge the oncologists to evaluate the role of platinum-doublet as second-line chemotherapy and establish the definition of platinum sensitivity in NSCLC. Methods: We retrospectively analyzed 364 advanced NSCLC patients who received platinum-doublet regimens as second-line chemotherapy after platinum-based first-line treatment. Patients were divided into four groups by their time-to-progression (TTP) after first-line chemotherapy: 0-3, 4-6, 7-12, and > 12months group, respectively. Treatment efficacy of patients’ overall survival (OS), progression-free survival (PFS) and response rate (RR), as well as treatment-related toxicity, were compared among the four groups. A prognosis score system and a nomogram were established by Cox proportional hazard model. Results: All patients had Eastern Cooperative Oncology Group performance status (ECOG PS) of 0-1.As part of the platinum-doublet regimen,145(39.8%) patients received taxol, 81(22.3%) received gemcitabine, 99(27.2%) received pemetrexed, 32(8.8%) received vinorelbine, 4(1.1%) received etoposide, and 3(0.8%) received irinotecan.The most frequent grade 3/4 toxicity was neutropenia (20.1%) and nausea/vomiting (3.3%).The median follow-up time was 11.0 months. Patients with TTP > 12 months had significant longer survival than the rest of the group after second-line platinum-rechallenge (HR, 0.809; 95% CI: 0.703-0.931;P = 0.003).Prognostic score was calculated by adding 1 point each for any of the following: TTP > 12 months, age ≤ 60 years, and female, all of which were independent prognostic factors for patient survival (P = 0.015, P = 0.002, P = 0.012, respectively). Median OS were equal to 25.0, 16.0 and 11.0 months for best (2-3 points), intermediate (1 point) and worst (0 point) category, respectively (P < 0.0001). Conclusions: A prognostic score (female, younger than 60 years, or TTP more than 12 months) of 2 or 3 points indicates a good prognosis if advanced NSCLC patients received platinum-rechallenge after disease progression.
Risks From Antipsychotic Medications in Children and Adolescents—Reply
Authors: Christopher Varley
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia
Authors: Cécile Thirant, Cathy Ignacimouttou, Cécile K. Lopez, M’Boyba Diop, Lou Le Mouël, Clarisse Thiollier, Aurélie Siret, Phillipe Dessen, Zakia Aid, Julie Rivière, Philippe Rameau, Céline Lefebvre, Mehdi Khaled, Guy Leverger, Paola Ballerini, Arnaud Petit, Hana Raslova, Catherine L. Carmichael, Benjamin T. Kile, Eric Soler, John D. Crispino, Christian Wichmann, Françoise Pflumio, Jürg Schwaller, William Vainchenker, Camille Lobry, Nathalie Droin, Olivier A. Bernard, Sébastien Malinge, Thomas Mercher
Journal: Cancer Cell (2017)
Interleukin 12 (IL12) and Interferon Gamma (IFNγ) of Donor Origin Not of Patient Origin May Predict Acute Graft Versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Authors: Azza M Kamel, Nahla M El-Sharkawy, Eman K Abd El-Fattah, Raafat Abd El-Fattah, Mohammed A Samra, Paul K. Wallace, Hossam K Mahmoud
Journal: Blood (2012)
Abstract 214: MicroRNA-451 Aggravates Lipotoxic Cardiomyopathy Through Suppression of the LKB1/AMPK Signaling Pathway
Authors: Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Toru Kita, Takeshi Kimura, Koh Ono
Journal: Circulation Research (2015)

Rationale: In some type 2 diabetes mellitus (T2D) patients without hypertension, cardiac hypertrophy and attenuated cardiac function are observed, and this insult is termed “diabetic cardiomyopathy.” Tons of evidence suggests that microRNAs are involved in cardiac diseases. However, the functions of microRNAs in the diabetic cardiomyopathy induced by T2D and obesity are not fully understood. Methods and Results: C57BL/6 mice were fed a high-fat diet (HFD) for 20 weeks, which induced obesity and T2D. MicroRNA microarray and real-time PCR revealed that miR-451 levels were significantly increased in the T2D mouse hearts (n=4-5, p&lt;0.05). Because excess supply of saturated fatty acids is a cause of diabetic cardiomyopathy, we stimulated neonatal rat cardiac myocytes (NRCMs) with palmitate in physiological albumin concentration and confirmed that miR-451 expression was increased in a dose-dependent manner (n=6-12, p&lt;0.01). Loss of miR-451 function ameliorated palmitate-induced lipotoxicity in NRCMs (n=4, p&lt;0.05). Calcium-binding protein 39 (Cab39) is a scaffold protein of liver kinase B1 (LKB1), an upstream kinase of AMP-activated protein kinase (AMPK). Cab39 was a direct target of miR-451 in NRCMs and Cab39 overexpression rescued the palmitate-induced lipotoxicity in NRCMs (n=4, p&lt;0.01). To clarify miR-451 functions in vivo, we generated cardiomyocyte-specific miR-451 knockout (cKO) mice. HFD-induced cardiac hypertrophy and contractile reserves were ameliorated in cKO mice compared with HFD-fed control mice. Protein levels of Cab39 and phosphorylated AMPK were increased and phosphorylated mammalian target of rapamycin (mTOR) was reduced in HFD-fed cKO mouse hearts compared with HFD-fed control mouse hearts (n=10-12, p&lt;0.05). We also measured the lipotoxic intermediates, triglyceride and ceramide, in these mouse hearts using HPLC-evaporative light scattering detector (ELSD). Although there was no difference in triglyceride levels (n=3-5), ceramide level was decreased in HFD-fed cKO mice compared with HFD-fed control mice (n=3-5, p&lt;0.05). Conclusions: Our results indicate that miR-451 exacerbates diabetic cardiomyopathy. miR-451 is a potential therapeutic target for cardiac disease caused by T2D and obesity.
Cyclophosphamide-induced renal damage in nude mice prevented by traditional Chinese medicine (TCM) herbal mixture LQ.
Authors: Chengyu Wu, Lei Zhang, Robert M. Hoffman
Journal: Journal of Clinical Oncology (2013)

e22210 Background: Renal damage is a dose-limiting side effects of cyclophosphamide (CYC). In the current study, we determined if a TCM herbal mixture LQ could be protective against CYC renal toxicity. Methods: Mice were treated with CYC or CYC+LQ. The histology of each organ was observed under microscopy after H&amp;E staining. Results: The histology of the heart, liver, spleen, lung and intestine showed normal histopathological structure in all groups. The kidney of the CYC-treated mice showed toxicity including the glomeruli, the tubules, and the interstitium. The structures of the cortex in CYC pretreated group showed a disconnection between glomeruli and tubules. The ducts in the medulla were destroyed. In contrast, the kidneys in the control mice, LQ-treated mice, and CYC+LQ-treated mice showed normal architecture of the kidney cortex and medulla. In the untreated controls and the CYC+LQ-treated mice, the cortex showed normal renal corpuscles, proximal convoluted tubules, and distal convoluted tubules. The inner medulla and outer medulla all contained a thick ascending limb of the loop of Henle, and interstitial connective tissue. LQ also protected against weight loss and cachexia induced by CYC. Conclusions: TCM is a promising for combination with CYC to reduce toxicity.
PROCEDURAL CALCIUM FRACTURE AND ITS EFFECT ON STENT EXPANSION ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY
Authors: Akiko Fujino, Gary Mintz, Kohei Koyama, Mitsuaki Matsumura, Myong Hwa Yamamoto, Dragos Alexandru, Joan Jennings, Patricia Krug, Lyn Santiago, Meghan Murray, Linda Bongiovanni, Fernando Sosa, Elizabeth Haag, Richard Shlofmitz, Akiko Maehara
Journal: Journal of the American College of Cardiology (2017)
PATTERNS OF DOWNSTREAM CARDIAC PROCEDURES AFTER NUCLEAR MYOCARDIAL PERFUSION IMAGING IN THE UNITED STATES, 2008-2012
Authors: Hong Jun Yun, Jessica Lehrich, Shashank S. Sinha, Richard L. Weinberg, Brahmajee K. Nallamothu, Venkatesh L. Murthy
Journal: Journal of the American College of Cardiology (2017)
DEPRESSION AS A POTENTIAL THERAPEUTIC TARGET TO IMPROVE QUALITY OF LIFE AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Jay Patel, William Fearon, Sammy Elmariah, Juyong Kim, Samir Kapadia, Dharam Kumbhani, Linda Gillam, Brian Whisenant, Nishath Quader, Frederick Welt, Hersh Maniar, Anthony Bavry, Alan Zajarias, Robert Piana, Spencer Melby, Megan Coylewright, Anna Vatterott, Kaitlin Stassi, Eric Novak, Brian Lindman
Journal: Journal of the American College of Cardiology (2017)
Treatment of Von Willebrand Disease Women Undergoing Childbirth with a Von Willebrand Factor Product with a Low Content of Factor VIII: Results From 4 Multicenter Studies
Authors: Catherine Boyer-Neumann, Annie Borel-Derlon, Jenny Goudemand, Ségolène Claeyssens, Pierre-Marie Sie, Philippe Moreau, Marie-Anne Bertrand, Chantal Rothschild, Benoît Guillet, Jeanne Yvonne Borg, Catherine Chatelanaz, Wil Stevens, Françoise Bridey, Celine Henriet
Journal: Blood (2012)
CHANGE IN RENAL FUNCTION DURING EXTENDED FOLLOW-UP AFTER LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION
Authors: Usama Daimee, Meng Wang, Anna Papernov, Saadia Sherazi, Scott McNitt, Himabindu Vidula, Leway Chen, Jeffrey Alexis, Valentina Kutyifa
Journal: Journal of the American College of Cardiology (2017)
Prognostic value of carbohydrate tumor markers and inflammation-based markers in Chinese advanced gastric cancer patients.
Authors: Weiwei Kong, Qing Wang, Jia Wei, Yang Yang, Yaping Zhang, Zhengyun Zou, Baorui Liu
Journal: Journal of Clinical Oncology (2015)

e15053 Background: Gastric cancer is the fourth most common cancer worldwide. In China, most cases are diagnosed as metastatic or recurrent gastric cancer (MRGC) with the 5-year survival rate being less than 5 %. It is important to obtain simple, feasible and cost-less markers to evaluate the prognosis of the MRGC patients. Methods: We investigated the correlation of tumor markers such as CEA, CA125, CA19-9, CA24-2, CA72-4 and inflammation-based factors such as mGPS, NLR and PLR with prognosis in 439 MRGC patients. Results: CA125 was more frequently positive with peritoneal recurrence, and CEA was more frequently positive in patients with liver metastases. In the univariate analysis of survival, the following variables were associated with shorter overall survival (OS) : male, previous pathology such as nerves invasion and vessel invasion, elevated CEA, CA72-4, CA125 and CA19-9, and inflammation-based variables such as Alb, CRP, mGPS, PLR, NLR, Hb, LDH, AchE and AKP. In the multivariate analysis, mGPS, CEA and CA125 were independent prognostic factors for OS. An exploration of the potential prognostic index model including the three independent factors was carried out, MSTs for the low-, moderate- and high-risk groups were 12, 10.5 and 5 months. Conclusions: Elevated serum CEA, CA125 and mGPS in patients with MRGC are independent negative predictors of prognosis.
Efficacy and Safety of the Bruton Tyrosine Kinase Inhibitor Ibrutinib in Patients with Hairy Cell Leukemia: Stage 1 Results of a Phase 2 Study
Authors: Jeffrey Jones, Leslie Andritsos, Robert J. Kreitman, Farhad Ravandi, Charles Schiffer, Timothy G. Call, Gerard Lozanski, Pamela Harris, Jennifer Sexton, Amy S Ruppert, Michael R. Grever
Journal: Blood (2016)
FRAILTY AS A RISK FACTOR FOR CARDIOVASCULAR VERSUS NON-CARDIOVASCULAR MORTALITY IN ELDERLY MEN: RESULTS FROM THE OUTCOMES OF SLEEP DISORDERS IN OLDER MEN (MROS SLEEP) STUDY
Authors: Selcuk Adabag, Tien N. Vo, Brent C. Taylor, Lisa Langsetmo, John T. Schousboe, Allyson Kats, Peggy Cawthon, Katie L. Stone, Marcia L. Stefanick, James Shikany, Thuy-Tien L. Dam
Journal: Journal of the American College of Cardiology (2017)
18F-FDG-PET/CT in Multiple Myeloma: High Intense PET Positive Lesions at Diagnosis Harbor Cytogenetic Adverse Subclones
Authors: Brian Østergaard, Anne L. Nielsen, Hanne E.H. Møller, Birgitte Preiss, Jon T. Asmussen, Julie R. Mortensen, Torben Plesner, Oke Gerke, Abass Alavi, Poul Flemming Høilund-Carlsen, Niels Abildgaard
Journal: Blood (2016)
SMOKING AND ITS RELATIONSHIP WITH LONG TERM EVENTS: FURTHER INSIGHTS FROM THE CONFIRM (CORONARY CT ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER) REGISTRY
Authors: Nima Omid-Fard, Amir Ahmadi, Philipp Blanke, Stephanie Sellers, Heidi Gransar, Daniel Berman, Tracy Callister, Augustin DeLago, Martin Hadamitzky, Joerg Hausleiter, Matthew Budoff, Philipp Kaufmann, Gilbert Raff, Kavitha Chinnaiyan, Todd Villines, Gudrun Feuchtner, Gianluca Pontone, Daniele Andreini, Hugo Marques, Ronen Rubinshtein, Stephan Achenbach, Leslee Shaw, Millie Gomez, James Min, Jonathon Leipsic
Journal: Journal of the American College of Cardiology (2017)
Preclinical In Vitro and In Vivo Evidence Support a Therapeutic Role for the CD70 Directed Monoclonal Antibody (SGN-70) in Waldenström’s Macroglobulinemia (WM).
Authors: Evdoxia Hatjiharissi, Allen W. Ho, Lian Xu, Kelly E. O’Connor, Zachary R. Hunter, Daniel D. Santos, Robert Manning, Xavier Leleu, Anne-Sophie Moreau, Christopher J. Patterson, Julie A. McEarchern, Che-Leung Law, Iqbal S. Grewal, Nikhil C. Munshi, Steven P. Treon
Journal: Blood (2006)
A tool to help research programs exceed the minimum standards of conducting clinical research.
Authors: Patricia Sandra Graham, Renee Yvonne Smith, Patricia A. Hurley
Journal: Journal of Clinical Oncology (2014)

e17618 Background: In 2008, ASCO published a statement to identify minimum standards and exemplary attributes of clinical trial sites. Recommendations were made to assist the development and implementation of high-quality research programs. A series of papers was published to elaborate on the standards and attributes. Respondents to a needs assessment survey of community-based research programs confirmed a gap/need for a quality assessment tool. ASCO’s Community Research Forum sought to develop a tool to assist community-based research sites in the development and implementation of an internal quality assurance program. Methods: A tool was developed to incorporate elements of ASCO publications on minimal standards and exemplary attributes of research sites. The tool was designed to help community-based research sites exceed minimum standards of conducting clinical research and provide an overview of ASCO’s recommendations of important components for internal quality assurance programs. A checklist tool was developed to help sites conduct an assessment of their program. Community-based researchers provided feedback about content and utilization in community-based research programs. Reviewers completed an online survey. Results: Sixteen community-based physician investigators and research staff completed the online survey. All respondents indicated the detail of the tool was sufficient; 94% indicated that it presented realistic expectations, in terms of resources required to implement; and 81% indicated that it would be valuable for conducting a quality assessment of their research program. Feedback from Community Research Forum’s Annual Meeting participants was favorable. Conclusions: Many community-based research programs do not have the resources to support an effective quality assurance program and may rely heavily on external audits. Resources should be allocated to create an internal quality assurance problem providing for self-directed continual process improvement. The ASCO Research Program Quality Assessment Tool provides methods to help community-based research sites exceed the minimum standards of conducting clinical research. The tool will be made available to the public in 2014.
A randomized clinical trial of ultrasound-guided infra-clavicular cannulation of the subclavian vein in cardiac surgical patients: short-axis versus long-axis approach
Authors: Antonella Vezzani, Tullio Manca, Claudia Brusasco, Gregorio Santori, Luca Cantadori, Andrea Ramelli, Gianluca Gonzi, Francesco Nicolini, Tiziano Gherli, Francesco Corradi
Journal: Intensive Care Medicine (2017)
Multiple Myeloma R-ISS Prognostic Stratification System in Real Life Population
Authors: Jakub Radocha, Vladimír Maisnar, Ludek Pour, Zdenek Adam, Ivan Spicka, Jan Straub, Vlastimil Scudla, Jiri Minarik, Evzen Gregora, Petr Pavlicek, Hana Frankova, Lenka Zahradova, Alexandra Jungova, Michal Sykora, Petr Kessler, Dagmar Adamova, Marek Wrobel, Lenka Sedlarikova, Sabina Sevcikova, Daniel Horinek, Jana Pelcova, Jiri Jarkovsky, Roman Hájek
Journal: Blood (2016)
META-ANALYSIS ON THE EFFICACY AND SAFETY OF NEW ORAL ANTICOAGULANTS COMPARED WITH VITAMIN K ANTAGONISTS IN PATIENTS UNDERGOING CARDIOVERSION FOR ATRIAL FIBRILLATION
Authors: Mohit Turagam, Poonam Velagapudi, Venkat Vuddanda, Madhav Lavu, Mohammad-Ali Jazayeri, Valay Parikh, Tushar Tarun, Donita Atkins, Kul Aggarwal, Sudharani Bommana, Luigi Di Biase, Andrea Natale, Madhu Reddy
Journal: Journal of the American College of Cardiology (2017)
Acute Kidney Injury in Children Admitted With Diabetic Ketoacidosis
Authors: Benjamin L. Laskin, Jens Goebel
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
EFFECT OF SACUBITRIL/VALSARTAN COMPARED WITH ENALAPRIL, ACCORDING TO ETIOLOGY IN PARADIGM-HF
Authors: Joanne Simpson, Pardeep Jhund, Jean Rouleau, Karl Swedberg, Michael Zile, Martin Lefkowitz, Victor Shi, Scott Solomon, Milton Packer, John McMurray
Journal: Journal of the American College of Cardiology (2017)
Influence of extent of lymphadenectomy on survival for localized non-small cell lung cancer.
Authors: Daniel Jacob Becker, Abdelaziz M. Elhaddad, Benjamin Philip Levy, Jason Dennis Wright, Bekir Tanriover, Faiz Y. Bhora, Juan P. Wisnivesky, Michael L. Grossbard
Journal: Journal of Clinical Oncology (2014)

6610 Background: Several studies suggest that more extensive lymph node dissection during surgery for localized non-small cell lung cancer (NSCLC) is associated with better prognosis. Given recent changes in therapy we sought to update previous analyses and include patients with higher stage, pathologically node negative (N0) disease. We further sought to identify clinical and demographic predictors of more extensive lymphadenectomy. Methods: We reviewed the SEER records of patients with N0 NSCLC, stage I-III diagnosed 2000-2010, who underwent lobectomy or pneumonectomy, with removal of > 1 lymph node (LN). We used the Cox proportional hazards model to examine the relationship between the number of LN examined and lung cancer specific survival (LCSS). We used linear and logistic regression to examine the relationship between clinical/demographic variables and number of LN removed. Results: We identified 34,233 patients with N0 NSCLC, treated with lobectomy/pneumonectomy between 2000 and 2010. The patients were 55.5% malewith medianage of 68;78.9% stage I, 7.9% stage II and 13% stage III. The median number of LN sampled was 7 (IQR 4-12). More LN resected at surgery were associated with improved OS and LCSS. Compared to patients with 1-3 LN resected, the hazard ratios for LCSS were 0.90 (CI 0.85-0.95) for 4-6 LN resected, 0.86 (CI 0.80-0.91) for 7-9 LN, 0.84 (CI 0.79-0.91) for 10-12 LN, 0.85 (CI 0.78-0.92) for 13-15 LN and 0.80 (CI 0.75-0.86) for > 16 LN resected. After controlling for age, gender, race, ethnicity, grade, stage, year of diagnosis and registry, little additional benefit was seen for resection of >7-9 LN. Older patients (age 70-80, OR 0.91), black race (OR 0.79), female (OR 0.90) and Hispanics (OR 0.81), were less likely to have > 7 LN resected. Patients diagnosed in 2005 and after (OR 1.15 - 1.62) were more likely to have > 7 LN resected. We also noted significant heterogeneity of LN resected by registry. Conclusions: In a current cohort of patients who had curative intent surgery for N0 NSCLC, the number of lymph nodes resected is strongly associated with LCSS. We propose that resection of 7 lymph nodes is feasible and may be considered a minimally acceptable number of nodes to be removed at curative resection of localized NSCLC.
PRIMARY CARDIAC LYMPHOMA: EARLY INITIATION OF CHEMOTHERAPY IS CRITICAL TO SAVE LIVES OF PATIENTS
Authors: Izumi Ito, Naoto Ohsawa, Satoshi Inotani, Yoko Nakaoka, Sho-Ichi Kubokawa, Kazuya Kawai, Naohisa Hamashige, Yoshinori Doi
Journal: Journal of the American College of Cardiology (2017)
Characteristics and Outcomes of Older Patients with Secondary AML According to Treatment Approach
Authors: Prajwal Chaitanya Boddu, Hagop M. Kantarjian, Guillermo Garcia-Manero, Srdan Verstovsek, Farhad Ravandi, Elias J. Jabbour, Koichi Takahashi, Kapil N. Bhalla, Marina Konopleva, Courtney D DiNardo, Maro Ohanian, Naveen Pemmaraju, Nitin Jain, Sherry Pierce, William G. Wierda, Jorge E. Cortes, Tapan M. Kadia
Journal: Blood (2016)