tbuckley/cabot-search huggingface dataset:
Abstract P257: Feeding Styles and Childhood Obesity in Rural Appalachia
Authors: Christa Ice, Kristin McCartney, Janie Leary, William Neal, Lesley Cottrell
Journal: Circulation (2013)

Researching mechanisms for treating childhood obesity is necessary for preventing associated health risks. One mechanism of change may be parental feeding styles, which may promote overweight in children. Permissive feeding style (high responsiveness, low demands) may result in child’s eating behaviors of eating quickly or being a picky eater. Authoritarian feeding style (high demands, low responsiveness) may result in children having control issues around food. Authoritative feeding styles (high demands and responsiveness) are characterized by appropriate eating behaviors. The goal of this study is to explore health outcomes of parenting styles. Procedure Data was collected via questionnaire from 2008-2010 CARDIAC Kindergarten, 2nd, 5th and 8th grade parents after participating in a statewide school-based health screening.1252 parents participated out of 8135 (15.4%) eligible parents. Parenting style questions resulted in 4 parenting styles: disengaged (6.8%), permissive (32.7%), authoritarian (4.2%), and authoritative (56.2%). Parent and Child Nutrition items were developed from USDA guidelines that include daily intake of fruits and vegetable subgroups of dark green, orange, legumes, and other vegetables. CDC epi info software calculated age and gender adjusted Body Mass Index (BMI) percentiles. Results 50.6% of the students were female, 93.8% Caucasian, 30.3% overweight or obese. Parenting style was associated with parent (p = .003), and child nutrition (p = .002); Figure 1. Specifically, authoritative differed from disengaged (p = .02 for parent, p = .01 for child) and permissive styles (p = .06 for parent, p = 0.01 for child). There was an effect of mean rank for BMI percentile across parenting styles (p = .047); children with permissive parents tended to be heavier than those with authoritative (p = .043). Discussion Improved outcomes among authoritative parents compared to permissive parents may suggest a venue for intervening on changeable parental behaviors in order to improve child health outcomes.
Body mass index standards for children
Authors: A. M Prentice
Journal: BMJ (1998)

The body mass index (weight (kg)/(height (m)2)) is widely accepted as providing a convenient measure of a person's fatness. It gives an index that is broadly independent of height and equally applicable to men and women. A few individuals who are exceptionally muscular may be misclassified as overweight or obese, but otherwise the body mass index provides a rather robust index which has proved exceptionally useful for large scale epidemiological work. Its use is rapidly spreading into adult clinical medicine, where several charts and nomograms are available. Similar charts now exist for children, but their use is less straightforward.

For adults a pragmatic classification system exists based on associations between body mass index and all cause mortality.1 The recently redefined body mass index categories are: underweight  40 kg/m2. These fixed classifications are not appropriate for children, in whom the 50th centile for body mass index shows profound changes from birth through to early adulthood …
Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation
Authors: Fatima Qadir, Mohammad Arshad Aziz, Chrisdina Puspita Sari, Hong Ma, Haiyan Dai, Xun Wang, Dhiresh Raithatha, Lucas Girotto Lagreca Da Silva, Muhammad Hussain, Seyedeh P. Poorkasreiy, Iain L. Hutchison, Ahmad Waseem, Muy-Teck Teh
Journal: Molecular Cancer (2018)

Exosomes are extracellular vesicles released by almost all cell types, including cancer cells, into bodily fluids such as saliva, plasma, breast milk, semen, urine, cerebrospinal fluid, amniotic fluid, synovial fluid and sputum. Their key function being intercellular communication with both neighbouring as well as distant cells. Cancer exosomes have been shown to regulate organ-specific metastasis. However, little is known about the functional differences and molecular consequences of normal cells responding to exosomes derived from normal cells compared to those derived from cancer cells. Here, we characterised and compared the transcriptome profiles of primary human normal oral keratinocytes (HNOK) in response to exosomes isolated from either primary HNOK or head and neck squamous cell carcinoma (HNSCC) cell lines. In recipient HNOK cells, we found that regardless of normal or cancer derived, exosomes altered molecular programmes involved in matrix modulation (MMP9), cytoskeletal remodelling (TUBB6, FEZ1, CCT6A), viral/dsRNA-induced interferon (OAS1, IFI6), anti-inflammatory (TSC22D3), deubiquitin (OTUD1), lipid metabolism and membrane trafficking (BBOX1, LRP11, RAB6A). Interestingly, cancer exosomes, but not normal exosomes, modulated expression of matrix remodelling (EFEMP1, DDK3, SPARC), cell cycle (EEF2K), membrane remodelling (LAMP2, SRPX), differentiation (SPRR2E), apoptosis (CTSC), transcription/translation (KLF6, PUS7). We have also identified CEP55 as a potential cancer exosomal marker. In conclusion, both normal and cancer exosomes modulated unique gene expression pathways in normal recipient cells. Cancer cells may exploit exosomes to confer transcriptome reprogramming that leads to cancer-associated pathologies such as angiogenesis, immune evasion/modulation, cell fate alteration and metastasis. Molecular pathways and biomarkers identified in this study may be clinically exploitable for developing novel liquid-biopsy based diagnostics and immunotherapies.
Solid Cell Nests Within a Parathyroid Gland—Report of an Exceptional Case
Authors: C. Christofer Juhlin, Inga-Lena Nilsson, Anders Höög
Journal: Endocrine Pathology (2018)

The ultimobranchial body (UBB) denotes the cellular mass originating from the fourth branchial pouch, which migrates from the neural crest and infolds within the middle and upper poles of the thyroid lobes, thereby establishing the presence of calcitonin-secreting parafollicular C cells. In various numbers, UBB remnants (entitled “solid cell nests”, or SCNs) are found in thyroid glands examined histologically. However, despite the close embryological relation between the UBB and the superior parathyroid glands, intraparathyroidal SCNs have to our knowledge not been previously reported. Here, we describe a patient presenting with a papillary thyroid carcinoma with central and lateral lymph node metastases. Upon postoperative analysis, an unintentionally removed parathyroid gland was observed adjacent to the superior aspect of the right thyroid lobe. Within a 0.6 × 0.5-mm area of the parathyroid gland, solid nests composed of epithelial cells with oval and slightly elongated nuclei were seen. The cells were positive for p40, p63, and GATA3, but negative for PTH. The final diagnosis was a SCN entrapped within the parathyroid gland. Empirically, we have not previously observed SCNs within the parathyroid glands. To our knowledge, our finding thus constitutes a very unusual histological manifestation, and could indicate an underlying aberrancy during embryogenesis given the close anatomical relationship between the UBB and the superior parathyroid glands.
Skin Deep
Authors: Peter A. Selwyn
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ABCC6 Deficiency Promotes Development of Randall Plaque
Authors: Emmanuel Letavernier, Gilles Kauffenstein, Léa Huguet, Nastassia Navasiolava, Elise Bouderlique, Ellie Tang, Léa Delaitre, Dominique Bazin, Marta de Frutos, Clément Gay, Joëlle Perez, Marie-Christine Verpont, Jean-Philippe Haymann, Viola Pomozi, Janna Zoll, Olivier Le Saux, Michel Daudon, Georges Leftheriotis, Ludovic Martin
Journal: Journal of the American Society of Nephrology (2018)

Background Pseudoxanthoma elasticum (PXE) is a genetic disease caused by mutations in the ABCC6 gene that result in low pyrophosphate levels and subsequent progressive soft tissue calcifications. PXE mainly affects the skin, retina, and arteries. However, many patients with PXE experience kidney stones. We determined the prevalence of this pathology in patients with PXE and examined the possible underlying mechanisms in murine models. Methods We conducted a retrospective study in a large cohort of patients with PXE and analyzed urine samples and kidneys from Abcc6 −/− mice at various ages. We used Yasue staining, scanning electron microscopy, electron microscopy coupled to electron energy loss spectroscopy, and Fourier transform infrared microspectroscopy to characterize kidney calcifications. Results Among 113 patients with PXE, 45 (40%) had a past medical history of kidney stones. Five of six computed tomography scans performed showed evidence of massive papillary calcifications (Randall plaques). Abcc6 −/− mice spontaneously developed kidney interstitial apatite calcifications with aging. These calcifications appeared specifically at the tip of the papilla and formed Randall plaques similar to those observed in human kidneys. Compared with controls, Abcc6 −/− mice had low urinary excretion of pyrophosphate. Conclusions The frequency of kidney stones and probably, Randall plaque is extremely high in patients with PXE, and Abcc6 −/− mice provide a new and useful model in which to study Randall plaque formation. Our findings also suggest that pyrophosphate administration should be evaluated for the prevention of Randall plaque and kidney stones.
Abstract 19112: Heart Failure With Preserved Ejection Fraction is Associated With Lower In-hospital Mortality Compared to Heart Failure With Reduced Ejection Fraction: A Nationwide Analysis
Authors: Bing Yue, Chayakrit Krittanawong, Shuyang Fang, Xin Wei, Mariam Khandaker, Allen Weiss, Eyal Herzog
Journal: Circulation (2017)

Introduction:  Heart Failure with Preserved Ejection Fraction (HFpEF) and Heart Failure with Reduced Ejection Fraction (HFrEF) share similar clinical phenotype however might lead to different outcomes. There is limited data comparing the hospitalization outcomes between HFpEF and HFrEF.   Hypothesis:  Outcomes in patients hospitalized with HFpEF and HFrEF are similar.   Methods:  This was a retrospective cohort study using the 2014 National Inpatient Sample (NIS) of adult patients hospitalized with HFpEF or HFrEF as the principal diagnosis. The primary outcomes were in-hospital mortality, mean length of stay (LOS) and mean total hospital charges. The secondary outcomes included ICU admission, shock, acute respiratory failure, and encounter for palliative care. Multivariable regression analysis was used to adjust for age, gender, race, Charlson Comorbidity Index, median annual income and hospital bed size.   Results:  A total of 586,510 patients with HFpEF or HFrEF were included in our study, and 46.9% of patients (275,340) were admitted with HFpEF. We found that patients with HFpEF were older (75 vs 70 years) and more likely female (62.6% vs 37.9%) than those with HFrEF (both  P ). Compared to patients with HFrEF, patients with HFpEF had lower in-hospital mortality (2.3% vs 2.7%), lower mean LOS (5.2 vs 5.4 days) and lower mean total hospital charges (US$ 38640 vs 48171) (all  P ). Similarly, regarding the secondary outcomes, patients with HFpEF had significantly lower rates of ICU admission (odds ratio [OR]: 0.67, 95% confidence interval [CI], 0.62-0.74), shock (OR: 0.39, 95% CI, 0.32-0.49), and encounter for palliative care (OR: 0.68, 95% CI, 0.64-0.73) (all  P ). However, the incidence of acute respiratory failure was statistically higher in patients with HFpEF (OR: 1.18, 95% CI, 1.15-1.23).   Conclusions:  Patients hospitalized with HFpEF had lower in-hospital mortality, shorter length of stay and lower healthcare costs compared to patients with HFrEF.
Broadening the View of Germline Mutations in Kidney Cancer
Authors: Patrick G. Pilié, Kathleen A. Cooney
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
The Influence of Foster Nursing upon the Incidence of Spontaneous Mammary Cancer in Resistant and Susceptible Mice
Authors: H. B. Andervont
Journal: JNCI Journal of the National Cancer Institute (1940)

Journal Article The Influence of Foster Nursing upon the Incidence of Spontaneous Mammary Cancer in Resistant and Susceptible Mice Get access H. B. Andervont H. B. Andervont senior biologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 1, Issue 2, October 1940, Pages 147–153, https://doi.org/10.1093/jnci/1.2.147 Published: 01 October 1940
Gut Microbiota: Acute Oral Administration of Single‐Walled Carbon Nanotubes Increases Intestinal Permeability and Inflammatory Responses: Association with the Changes in Gut Microbiota in Mice (Adv. Healthcare Mater. 13/2018)
Authors: Hanqing Chen, Ruifang Zhao, Bing Wang, Lingna Zheng, Hong Ouyang, Hailong Wang, Xiaoyan Zhou, Dan Zhang, Zhifang Chai, Yuliang Zhao, Weiyue Feng
Journal: Advanced Healthcare Materials (2018)

Whether the oral exposure of single-walled carbon nanotubes (SWCNTs) have an impact on the homeostasis of gut microbiota is an essential step for their safe application. In article 1701313 by Weiyue Feng and co-workers, the deposited SWCNTs in the intestinal tract disturb intestinal integrity, perform antibacterial activity and drive the compositional alteration in gut microbiota, consequently triggering the “metabolic inflammation” responses.
STENTING VERSUS PALLIATIVE SURGERY FOR MALIGNANT GASTRODUODENAL AND JEJUNAL OBSTRUCTION
Authors: S Davydova, A Fedorov, A Klimov
Journal: Endoscopy (2018)

Surgical formation of gastrojejunoanastomosis or jejunostoma and endoscopic self-expandable metal stent placement are two widely used palliative treatment methods for malignant gastroduodenal and jejunal obstruction, and a question of choice between them is still a controversial point. The aim of the study was to compare early and long-term outcomes of gastroenteral stenting versus traditional surgical palliation.
Abstract 18434: Modulation of N6-Methyladenosine (m6A) as a Novel Mechanism of Human CD34+ Stem Cell-Derived Exosomes in Cardiac Repair
Authors: Prabhu Mathiyalagan, Yaxuan Liang, Marta Adamiak, Yassine Sassi, Neha Agarwal, Kiyotake Ishikawa, Roger J Hajjar, Susmita Sahoo
Journal: Circulation (2017)

Introduction: Exosomes transfer selective set of miRNAs from the cell of their origin that is crucial to regulating gene expression and function of the recipient cells. Our lab has shown that human...
Is chronic breathlessness less recognised and treated compared with chronic pain? A case-based randomised controlled trial
Authors: Zainab Ahmadi, Jacob Sandberg, Aaron Shannon-Honson, Zac Vandersman, David C. Currow, Magnus Ekström
Journal: European Respiratory Journal (2018)

Chronic breathlessness is a major cause of suffering in chronic obstructive pulmonary disease (COPD) [1]. Despite the impact on patients' daily lives, chronic breathlessness might be under-recognised and under-treated. No previous study has explored physicians' ability to identify chronic breathlessness in relation to other chronic symptoms. This study highlights the need for improved assessment and management of chronic breathlessness in clinical practice <http://ow.ly/S7Ua30kPmjW> The authors thank the Swedish Respiratory Society, the Swedish Society of Internal Medicine, and the Swedish Society of Primary Care for help with standardising recruitment, and all physicians who participated and made this trial possible.
Drenaje de colecciones pancreáticas (CP) mediante prótesis metálicas de aposición luminal (PAL) vs prótesis metálica biliar totalmente recubierta (PMBR): ¿Cuál deberíamos utilizar?
Authors: E Vázquez-Sequeiros, A García García De Paredes, JR Foruny, JÁ González Martín, F González-Panizo, V Defarges, D Juzgado, A Albillos
Journal: Endoscopy (2017)

El drenaje endoscópico de CP mediante prótesis metálicas (PM) ha demostrado gran eficacia. La experiencia con las PMBR es mayor que con las PAL.
Bacteraemia and Upper Gastrointestinal Fibre-Endoscopy
Authors: A Kirk, R Graham-Brown, R M Perinpanayagam, R G Smith, D E Barnardo
Journal: Journal of the Royal Society of Medicine (1979)

A prospective study of fifty-two patients undergoing fibreoptic upper gastrointestinal endoscopy was carried out in order to determine whether bacteraemia was a significant risk. Aerobic and anaerobic blood cultures were performed before, during and after endoscopy. Cultures were also taken from lesions (if any found) in the oesophagus, stomach or duodenum. No significant bacteraemia was identified, and bacterial growth was found in only one upper gastrointestinal lesion.
Modeling of patient virus titers suggests that availability of a vaccine could reduce hepatitis C virus transmission among injecting drug users
Authors: Marian Major, Alexander Gutfraind, Louis Shekhtman, Qingwen Cui, Alla Kachko, Scott J. Cotler, Behzad Hajarizadeh, Rachel Sacks-Davis, Kimberly Page, Basmattee Boodram, Harel Dahari
Journal: Science Translational Medicine (2018)

A future vaccine could reduce hepatitis C virus transmission among those sharing syringes, even in the presence of postexposure viral replication in vaccinees.
Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study
Authors: Rohan Khera, Yuan Lu, Jiapeng Lu, Anshul Saxena, Khurram Nasir, Lixin Jiang, Harlan M Krumholz
Journal: BMJ (2018)

To examine the effect of the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) hypertension guidelines on the prevalence of hypertension and eligibility for initiation and intensification of treatment in nationally representative populations from the United States and China.Observational assessment of nationally representative data.US National Health and Nutrition Examination Survey (NHANES) for the most recent two cycles (2013-14, 2015-16) and China Health and Retirement Longitudinal Study (CHARLS) (2011-12).All 45-75 year old adults who would have a diagnosis of hypertension and be candidates for treatment on the basis of the ACC/AHA guidelines, compared with current guidelines.Diagnosis of hypertension and candidacy for initiation and intensification of antihypertensive treatment.Adoption of the 2017 ACC/AHA hypertension guidelines in the US would label 70.1 (95% confidence interval 64.9 to 75.3) million people in the 45-75 year age group as having hypertension, representing 63% (60.6% to 65.4%) of the population in this age group. Their adoption in China would lead to labeling of 266.9 (252.9 to 280.8) million people or 55% (53.4% to 56.7%) of the same age group as having hypertension. This would represent an increase in prevalence of 26.8% (23.2% to 30.9%) in the US and 45.1% (41.3% to 48.9%) in China. Furthermore, on the basis of treatment patterns and current guidelines, 8.1 (6.5 to 9.7) million Americans with hypertension are untreated, which would be expected to increase to 15.6 (13.6 to 17.7) million after the implementation of the ACC/AHA guidelines. In China, on the basis of current treatment patterns, 74.5 (64.1 to 84.8) million patients with hypertension are untreated, estimated to increase to 129.8 (118.7 to 140.9 million. In addition, the ACC/AHA guidelines would label 8.7 (6.0 to 11.5) million adults in the US and 51 (40.3 to 61.6) million in China as having hypertension that would not require antihypertensive treatment, compared with 1.5 (1.2 to 2.1) million and 23.4 (12.1 to 35.1) million with the current guidelines. Finally, even among people receiving treatment, the proportion that are candidates for intensification of treatment is estimated to increase by 13.9 (12.2 to 15.6) million (from 24.0% to 54.4% of treated patients) in the US, and 30 (24.3 to 35.7) million (41.4% to 76.2% of treated patients) in China, if the ACC/AHA treatment targets are adopted.If adopted, the 2017 ACC/AHA hypertension guidelines will markedly increase the number of people labeled as having hypertension and treated with drugs in both the US and China, leading to more than half of those aged 45-75 years in both countries being considered hypertensive.
Abstract 13828: Fhos Expression is Required for Striated Flight Muscle Formation and Viability in Flies
Authors: Jenna E Calvino, Alessandra Alicea, Isabelle Draper, Gordon S Huggins
Journal: Circulation (2013)

Recently we demonstrated that a peptide variant of FHOD3, an actin filament regulator, is associated with Hypertrophic Cardiomyopathy (HCM), and that the FHOD3 D. melanogaster homologue fhos is req...