Interleukin-1 Inhibitors and Dacryoadenitis in Adult-Onset Still Disease
Authors: Paul Breillat, Maylis Tourte, Pierre Romero, Gilles Hayem, Ilaria Padovano, Félicie Costantino, Maxime Breban
Journal: Annals of Internal Medicine (2017)

Letters20 March 2018Interleukin-1 Inhibitors and Dacryoadenitis in Adult-Onset Still DiseasePaul Breillat, MD, Maylis Tourte, MD, Pierre Romero, MD, Gilles Hayem, MD, PhD, Ilaria Padovano, MD, Félicie Costantino, MD, PhD, and Maxime Breban, MD, PhDPaul Breillat, MDAmbroise Paré Hospital, Boulogne, France (P.B., M.T., P.R., G.H., I.P., F.C., M.B.), Maylis Tourte, MDAmbroise Paré Hospital, Boulogne, France (P.B., M.T., P.R., G.H., I.P., F.C., M.B.), Pierre Romero, MDAmbroise Paré Hospital, Boulogne, France (P.B., M.T., P.R., G.H., I.P., F.C., M.B.), Gilles Hayem, MD, PhDAmbroise Paré Hospital, Boulogne, France (P.B., M.T., P.R., G.H., I.P., F.C., M.B.), Ilaria Padovano, MDAmbroise Paré Hospital, Boulogne, France (P.B., M.T., P.R., G.H., I.P., F.C., M.B.), Félicie Costantino, MD, PhDAmbroise Paré Hospital, Boulogne, France (P.B., M.T., P.R., G.H., I.P., F.C., M.B.), and Maxime Breban, MD, PhDAmbroise Paré Hospital, Boulogne, France (P.B., M.T., P.R., G.H., I.P., F.C., M.B.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0401 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Adult-onset Still disease is a systemic inflammatory condition of unknown origin. Spiking fever, evanescent rash, sore throat, myalgia, arthritis, and organomegaly are the typical clinical manifestations. Ophthalmic manifestations occur less frequently and commonly include uveitis, keratitis, ptosis, oculomotor disorders, erythema, chemosis, and orbital pseudotumor (1).Objective: To remind clinicians that adult-onset Still disease can cause inflammation of the lacrimal glands (dacryoadenitis) and to report the value of interleukin-1 (IL-1) inhibitors in treating this inflammation.Case Report: A 45-year-old woman with adult-onset Still disease had achieved long-standing remission with oral prednisone, 9 mg/d, and intravenous tocilizumab, 8 mg/kg of body ...References1. Cush JJ, Leibowitz IH, Friedman SA. Adult-onset Still's disease and inflammatory orbital pseudotumor. N Y State J Med. 1985;85:110-1. [PMID: 3857478] MedlineGoogle Scholar2. Bannai E, Yamashita H, Takahashi Y, Tsuchiya H, Mimori A. Two cases of adult-onset Still's disease with orbital inflammatory lesions originating from the lacrimal gland. Intern Med. 2015;54:2671-4. [PMID: 26466709] doi:10.2169/internalmedicine.54.4838 CrossrefMedlineGoogle Scholar3. Kontzias A, Efthimiou P. The use of canakinumab, a novel IL-1ß long-acting inhibitor, in refractory adult-onset Still's disease. Semin Arthritis Rheum. 2012;42:201-5. [PMID: 22512815] doi:10.1016/j.semarthrit.2012.03.004 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Ambroise Paré Hospital, Boulogne, France (P.B., M.T., P.R., G.H., I.P., F.C., M.B.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0401.Reproducible Research Statement:Study protocol, statistical code, and data set: Not applicable.This article was published at Annals.org on 12 December 2017. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBilateral dacryoadenitis in adult-onset Still’s disease: A case reportAdult Still's disease: New horizonsEfficacy and safety of canakinumab in the treatment of adult-onset Still's disease: A systematic reviewManagement of adult-onset Still’s disease with interleukin-1 inhibitors: evidence- and consensus-based statements by a panel of Italian experts 20 March 2018Volume 168, Issue 6Page: 455-456KeywordsAntibioticsArthritisDisclosureEdemaFeversInflammationMyalgiaRashesResearch laboratoriesStatistical data ePublished: 12 December 2017 Issue Published: 20 March 2018 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...