tbuckley/cabot-search huggingface dataset:
Abstract #4846: Serum vitamin D concentrations and bone health among women with breast cancer on aromatase inhibitors
Authors: Lisa Gallicchio, Bethany Wood, Errol Rushovich, Neal Fedarko, Kathy Helzlsouer
Journal: Cancer Research (2009)

Introduction. Aromatase inhibitors have rapidly become the hormonal adjuvant treatment of choice for postmenopausal breast cancer. While there are clear benefits of this treatment, an important clinical concern among breast cancer patients taking aromatase inhibitors is bone loss. The purpose of this study was to examine bone health among breast cancer patients taking aromatase inhibitors and, specifically, the association between bone density and musculoskeletal symptoms. In addition, we examined whether bone density was associated with serum 25-hydroxyvitamin D, calcium, or C-reactive protein (CRP) among breast cancer patients taking aromatase inhibitors. Methods. Data were analyzed from104 breast cancer patients taking aromatase inhibitors, 42 breast cancer patients not taking aromatase inhibitors, and 150 women without a history of cancer enrolled in a study at Mercy Medical Center in Baltimore, Maryland. Information was collected on the presence of joint, muscle and bone pain. Blood samples were collected and processed within two hours and the serum was frozen at -70°C until assayed for vitamin D, calcium, and CRP. Bone density of the distal radius and proximal phalanx III was measured using the Sunlight Omnisense 700S. Low bone density was defined as having a measurement more than 1 standard deviation from the matched population reference value of the same age, gender, and ethnic group for at least one of the sites. Results. Approximately 42% of the breast cancer patients taking aromatase inhibitors were categorized as having low bone density compared to 18% of breast cancer patients not taking aromatase inhibitors and 14% of the healthy controls (p   Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4846.
Intensive Intervention to Improve Outcomes for Patients With COPD
Authors: Seppo T. Rinne, Peter K. Lindenauer, David H. Au
Journal: JAMA (2018)

Hanan Aboumatar, MD, MPH; Mohammad Naqibuddin, MBBS, MPH; Suna Chung, MPH; Hina Chaudhry, MPH; Samuel W. Kim, BA; Jamia Saunders, MD, MS; Lee Bone, MPH; Ayse P. Gurses, MS, MPH, PhD; Amy Knowlton, ScD, MPH; Peter Pronovost, MD, PhD; Nirupama Putcha, MD, MHS; Cynthia Rand, PhD; Debra Roter, DrPH; Carol Sylvester, RN, MS; Carol Thompson, MS, MBA; Jennifer L. Wolff, PhD; Judith Hibbard, PhD, MPH, FCCM; Robert A. Wise, MD
Association between hidradenitis suppurativa and hospitalization for psychiatric disorders: a cross‐sectional analysis of the National Inpatient Sample
Authors: K.R. Patel, S. Rastogi, V. Singam, H.H. Lee, A.Z. Amin, J.I. Silverberg
Journal: British Journal of Dermatology (2018)

Hidradenitis suppurativa (HS) is associated with pain, disfigurement, psychosocial distress and poor quality of life, all of which may lead to a higher likelihood of mental health (MH) disorders. However, little is known about the MH comorbidities of HS. To determine the MH disorders and cost burden associated with HS. Data were examined from the 2002–2012 National Inpatient Sample, comprising approximately a 20% sample of all U.S. paediatric and adult hospitalizations (87 053 155 admissions). MH disorders were much more common in inpatients with vs. without HS (34·27% vs. 20·05%). In multivariable logistic regression models controlling for sex, age, race/ethnicity and insurance status, HS was associated with significantly higher odds of an MH disorder (adjusted odds ratio 2·53, 95% confidence interval 2·42–2·63), including 10 of 15 MH disorders examined. In contrast, HS was not associated with primary hospitalization for an MH disorder overall (odds ratio 0·95, 95% confidence interval 0·84–1·07), but it was associated with primary hospitalization for eight of 15 MH disorders examined. Among inpatients with HS, primary admission for an MH disorder was associated with female sex, public or no insurance and more chronic diseases, but inversely associated with older age and nonwhite race/ethnicity. HS was associated with > $38 million (USD) of excess mean annual costs of hospitalization for MH disorders. Inpatients with HS had increased odds of comorbid MH disorders, overall, and multiple primary MH admissions, in particular, which were associated with considerable excess costs.
Cuba pulls more than 8000 doctors out of Brazil after qualifications are questioned
Authors: Owen Dyer
Journal: BMJ (2018)

Cuba has said that it will bring more than 8000 doctors back from Brazil after that country’s president elect, Jair Bolsonaro, made comments that Cuba’s health ministry called “contemptuous and threatening to the presence of our doctors.”

Cuban nationals account for more than half of the 16 000 doctors working in Brazil’s “More Doctors” (Mais Medicos) programme, started in 2013 by the former president Dilma Rousseff to deliver healthcare to the country’s poorest and most remote regions.

On 2 November Bolsonaro, who has yet to take up office, told Brasilia’s Correio Braziliense newspaper that the Cuban doctors would all have to requalify in Brazil.

Cuba’s health ministry said in a statement announcing the end of their participation, “It is not acceptable to question the dignity, professionalism, and altruism of Cuban co-workers.” 1

The president of Brazil’s National Council of Municipal Health Secretariats …
Abstract P141: Usual Impact of Vegetable and Red Meat Intake on Urinary Nitrate
Authors: Tianying Wu, Samantha Sonoda, Nicholas Ollberding
Journal: Circulation (2016)

The purpose of this study is twofold: 1) compare the effectiveness of non-quantitative food frequency questionnaire (NFFQ) to one-time or multiple 24-hr recalls on assessing the associations of vegetable and meat intakes with urinary nitrate; 2) to determine the associations of vegetable and meat intakes with urinary nitrate. Nitrate-related metabolic pathways have emerged as a fascinating topic because promising benefits of using nitrate supplement on several cardiovascular related outcomes in animal and small-scaled human intervention studies. In the past, most people consider that processed meat is the main source of nitrate exposure and nitrate is harmful. In fact, the major exogenous nitrate exposure comes from vegetables. Thus, we seek to untangle the mystery vegetable-nitrate and meat-nitrate associations in a large observational study. We conduct a cross-sectional analysis using the National Health and Nutrition Examination Survey (NHANES) during 2005-2006, among 7,683 participants. Urinary nitrate was measured, NFFQ and two-time 24-hr recalls were collected among these participants. We have found a positive association between vegetable intakes and urinary nitrate and an inverse association between red meat and processed meat intakes and urinary nitrate by using either non-quantitative NFFQ or averaged two-time 24-hr recalls. The magnitudes of the results were stronger when using NFFQ. Further, using NFFQ, we found that urinary nitrate intake increased by 26%, and decreased by 16% when comparing persons with the highest to the lowest quintile of vegetable intake and red and processed meat intake, respectively. Lastly, we found that the results from the 24-hr recall collected a few days after urine collection (but not the 24-hr recall on the day of urine collection) are consistent with NFFQ results. The trend of vegetable-urinary nitrate and red meat-urinary nitrate associations from NFFQ and averaged 24-hr recalls were consistent with our previous published findings using plasma nitrate measurement in the Health Professionals Follow-up Study, where only semi-quantitative FFQ (SFFQ) was administered. In summary, we conclude that dietary assessment with NFFQ,SFFQ, or average 24-hr recalls will yield similar results when evaluating red meat-circulating nitrate or vegetable-circulating nitrate associations. Measurement of circulating nitrate using either urine or plasma will yield similar results. Understanding how usual vegetable and red meat intake influences circulating nitrate in observational studies will provide valuable information for studying nitrate related pathways in the etiology of chronic disease and for designing long-term dietary intervention studies targeting circulating nitrate.
Examining skeletal-related events in Australian men with castration-resistant prostate cancer (CRPC)
Authors: A. Anton, S. Wong, P. Parente, A. Azad, J.A. Shapiro, A. Weickhardt, J. Torres, F. Parnis, J. Goh, C. Semira, P. Gibbs, B. Tran, C. Pezaro
Journal: Annals of Oncology (2018)
Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations
Authors: Ratna Tripathy, Ines Leca, Tessa van Dijk, Janneke Weiss, Bregje W. van Bon, Maria Christina Sergaki, Thomas Gstrein, Martin Breuss, Guoling Tian, Nadia Bahi-Buisson, Alexander R. Paciorkowski, Alistair T. Pagnamenta, Andrea Wenninger-Weinzierl, Maria Fernanda Martinez-Reza, Lukas Landler, Stefano Lise, Jenny C. Taylor, Gaetano Terrone, Giuseppina Vitiello, Ennio Del Giudice, Nicola Brunetti-Pierri, Alessandra D’Amico, Alexandre Reymond, Norine Voisin, Jonathan A. Bernstein, Ellyn Farrelly, Usha Kini, Thomas A. Leonard, Stéphanie Valence, Lydie Burglen, Linlea Armstrong, Susan M. Hiatt, Gregory M. Cooper, Kimberly A. Aldinger, William B. Dobyns, Ghayda Mirzaa, Tyler Mark Pierson, Frank Baas, Jamel Chelly, Nicholas J. Cowan, David Anthony Keays
Journal: Neuron (2018)
Pseudoprogression in Previously Treated Patients with Non–Small Cell Lung Cancer Who Received Nivolumab Monotherapy
Authors: Daichi Fujimoto, Hiroshige Yoshioka, Yuki Kataoka, Takeshi Morimoto, Tae Hata, Young Hak Kim, Keisuke Tomii, Tadashi Ishida, Masataka Hirabayashi, Satoshi Hara, Manabu Ishitoko, Yasushi Fukuda, Moon Hee Hwang, Naoki Sakai, Motonari Fukui, Hitoshi Nakaji, Mitsunori Morita, Tadashi Mio, Takehiro Yasuda, Takakazu Sugita, Toyohiro Hirai
Journal: Journal of Thoracic Oncology (2018)
ALK rearrangent in pulmonary sarcomatoid carcinoma: A retrospective study of the real world
Authors: Y.-C. Zhu, C. Xu, W.-X. Wang, M.-Y. Fang, W. Zhuang, Q.-X. Zhang, Z. Gong, Y.-P. Chen, G. Chen, T.-F. Lv, Y. Song
Journal: Annals of Oncology (2018)
IL-1 Blockade Reduces Inflammation in Pulmonary Arterial Hypertension and Right Ventricular Failure: A Single-Arm, Open-Label, Phase IB/II Pilot Study
Authors: Cory R. Trankle, Justin M. Canada, Dinesh Kadariya, Roshanak Markley, Horacio Medina De Chazal, Janet Pinson, Adam Fox, Benjamin W. Van Tassell, Antonio Abbate, Daniel Grinnan
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Over time, patients with longstanding pulmonary arterial hypertension (PAH) experience pressure overload in the right ventricle (RV), leading to reduced contractile force and chamber dilation.Present strategies to treat PAH consist of pulmonary arterial vasodilators by way of the prostacyclin, endothelin, or nitric oxide pathways.It is now appreciated that maladaptive inflammatory signaling is a key contributor to the development of obliterative pulmonary arteriolar lesions and RV failure in PAH (1, 2), and that IL-1 and IL-6 levels correlate with the degree of RV failure (3).With experimental animal data suggesting anakinra (recombinant IL-1 receptor antagonist) protects against development of PAH (4), we designed a single-group, open-label phase IB/II pilot study (clinicaltrials.govidentifier: NCT03057028) to evaluate the feasibility and safety of treatment with anakinra as add-on therapy to standard of care in patients with stable PAH and RV failure.In addition to the preclinical data, anakinra was chosen on the basis of multiple favorable clinical trials in left-sided systolic dysfunction by our group (5, 6).Here we report the findings from our pilot study.From October 2017 to May 2018, patients at the Virginia Commonwealth University treated for pulmonary hypertension were screened for eligibility.Inclusion criteria included group 1 PAH ( 7) (not associated with connective tissue disease, human immunodeficiency virus, portal hypertension, or schistosomiasis), age .18years, and symptomatic RV failure (objective findings of RV dysfunction by echocardiography [RV diastolic diameter .4.3 cm, fractional area change ,35%, or tricuspid annular plane systolic excursion <1.5 cm] with New York Heart Association class II or III heart failure symptoms) despite optimal PAH therapy.Exclusion criteria included autoimmune/autoinflammatory diseases, anti-inflammatory medications, recent malignancy or infection, and severe renal dysfunction.Of the 39 patients who met inclusion criteria, 10 were excluded (chronic inflammatory disorders [n = 4], infection [n = 1], severe renal dysfunction [n = 2], non-English speaking [n = 1], unable to consent [n = 1], pregnant [n = 1]). Sixteen patients were approached for the study: 6 declined to participate, and 10 agreed to enroll, which was the sample size chosen to gather preliminary data.However, scheduling conflicts prevented two patients from completing
Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stress-induced intestinal permeability
Authors: Susan D'Costa, Saravanan Ayyadurai, Amelia J. Gibson, Emily Mackey, Mrigendra Rajput, Laura J. Sommerville, Neco Wilson, Yihang Li, Eric Kubat, Ananth Kumar, Hariharan Subramanian, Aditi Bhargava, Adam J. Moeser
Journal: Journal of Allergy and Clinical Immunology (2018)
Association of Age With Blood Pressure Across the Lifespan in Isolated Yanomami and Yekwana Villages
Authors: Noel T. Mueller, Oscar Noya-Alarcon, Monica Contreras, Lawrence J. Appel, Maria Gloria Dominguez-Bello
Journal: JAMA Cardiology (2018)

Absence of Association of Blood Pressure With Age Renews the Call for Population-Wide Interventions—Reply
HbA1c, Insulin Resistance, and β-Cell Function in Relation to Cognitive Function in Type 2 Diabetes: The CAROLINA Cognition Substudy
Authors: Jolien Janssen, Esther van den Berg, Bernard Zinman, Mark A. Espeland, Stefan L.C. Geijselaers, Michaela Mattheus, Odd Erik Johansen, Geert Jan Biessels
Journal: Diabetes Care (2018)

Cognitive dysfunction is increasingly recognized as a complication of type 2 diabetes. There is a growing evidence for etiologic roles of glycemia and insulin resistance, although important questions remain (1,2). Elevated levels of glycosylated hemoglobin (HbA1c) appear to be related to worse cognition, but there are indications that the same holds true for lower HbA1c levels, possibly because intensive glycemic control increases the risk of hypoglycemia (1). Previous studies relating HbA1c to cognition did not sufficiently address this possible nonlinear relationship. Regarding insulin resistance, it has been postulated that disturbances in cerebral insulin signaling might negatively affect cognition (2). Indeed, in individuals without type 2 diabetes, both hyperinsulinemia and insulin resistance have been related to poorer cognitive performance and dementia (2). However, a comprehensive understanding of the interrelationship between markers of insulin homeostasis and cognition in type 2 diabetes is still lacking (1). Finally, there may be interindividual differences in susceptibility for developing cognitive dysfunction, where factors such as age and sex could modify the relations between glycemia, insulin resistance, and cognition. We therefore investigated, in a large cohort of patients with type 2 diabetes, how HbA1c and indices of insulin resistance and β-cell function relate to cognitive function, specifically addressing potential nonlinear associations and the influence of age and sex.

We studied participants of the cognition substudy of the CAROLINA (CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 …
SNP-Array Genome Wide Association Study Meta-Analysis Identifies Innate Immune Susceptibility Loci Associated with Non-Del(5q) Myelodysplastic Syndromes Predisposition
Authors: Kathy L McGraw, Chia-Ho Cheng, Y. Ann Chen, Hsin-An Hou, Guilio Genovese, Thomas Cluzeau, Andrea Pellagatti, Bartlomiej Przychodzen, Mar Mallo, Arenillas Leonor, Azim M. Mohamedali, Lionel Ades, David A Sallman, Eric Padron, Lubomir Sokol, Chimene Moreilhon, Sophie Raynaud, Bjorn Nilsson, Hwei-Fang Tien, Jacqueline Boultwood, Benjamin L. Ebert, Francesc Sole, Pierre Fenaux, Ghulam Mufti, Jaroslaw P. Maciejewski, Peter Kanetsky, Alan F. List
Journal: Blood (2018)
Association of Concussion With the Risk of Suicide
Authors: Michael Fralick, Eric Sy, Adiba Hassan, Matthew J. Burke, Elizabeth Mostofsky, Todd Karsies
Journal: JAMA Neurology (2018)

Concussion is the most common form of traumatic brain injury (TBI). While most patients fully recover within 1 week of injury, a subset of patients might be at a higher risk of suicide.To assess the risk of suicide after concussion.We performed a systematic search of Medline (PubMed), Embase, PsycINFO, and Published International Literature on Traumatic Stress (PILOTS) from 1963 to May 1, 2017. We also searched Google Scholar and conference proceedings and contacted experts in the field to seek additional studies.Studies that quantified the risk of suicide, suicide attempt, or suicidal ideation after a concussion and/or mild TBI were included. Studies that included children and adults, including military and nonmilitary personnel, were included. Two authors independently reviewed all titles and abstracts to determine study eligibility.Study characteristics were extracted independently by 2 trained investigators. Study quality was assessed using the Newcastle-Ottawa Scale. Study data were pooled using random-effects meta-analysis.The primary exposure was concussion and/or mild TBI, and the primary outcome was suicide. Secondary outcomes were suicide attempt and suicidal ideation.Data were extracted from 10 cohort studies (n = 713 706 individuals diagnosed and 6 236 010 individuals not diagnosed with concussion and/or mild TBI), 5 cross-sectional studies (n = 4420 individuals diagnosed and 11 275 individuals not diagnosed with concussion and/or mild TBI), and 2 case-control studies (n = 446 individuals diagnosed and 8267 individuals not diagnosed with concussion and/or mild TBI). Experiencing concussion and/or mild TBI was associated with a 2-fold higher risk of suicide (relative risk, 2.03 [95% CI, 1.47-2.80]; I2 = 96%; P < .001). In 2 studies that provided estimates with a median follow-up of approximately 4 years, 1664 of 333 118 individuals (0.50%) and 750 of 126 114 individuals (0.59%) diagnosed with concussion and/or mild TBI died by suicide. Concussion was also associated with a higher risk of suicide attempt and suicide ideation. The heightened risk of suicide outcomes after concussion was evident in studies with and without military personnel.Experiencing concussion and/or mild TBI was associated with a higher risk of suicide. Future studies are needed to identify and develop strategies to decrease this risk.
Hybrid peptides containing a high affinity hsp70 binding sequence, cleavable linker and MHC class I epitope enhance CD8+ T cell specific immunity in the presence of hsp70
Authors: Kenya P. Cohane, Jessica B. Flechtner, Sunil Mehta, Paul Slusarewicz, Brian Barber, Daniel L. Levey, Sofija Andjelic
Journal: Cancer Research (2005)

5131  Heat shock proteins (HSPs) chaperone proteins and peptides into the endogenous antigen-processing pathway and stimulate CD8+ T cell immunity against cancer and infectious agents. One potential limitation of HSP-based vaccines is that many natural epitopes have relatively low binding affinities for chaperones, thereby reducing their likelihood of being presented to the immune system. Here we depict an optimized strategy of engineering MHC class I epitopes to augment their binding affinity for hsp70 and as a result, increase immunogenicity. The collinear synthesis of a hybrid peptide containing an hsp70-binding sequence (Javelin™, J1=NLLRLTGW) and a 3 amino acid flexible linker (L1=GSG) at the C-terminus of class I epitopes that rendered otherwise poorly binding peptides immunogenic was previously described by our group. Our new data show that relocating the Javelin and linker from the C- to the N-terminus of an epitope does not adversely affect the binding affinity of the peptide for hsp70; however, comparisons using the SIINFEKL (Ova) epitope demonstrate that J1-L1-Ova:hsp70 complexes induce better CD8+ T cell responses than Ova-L1-J1:hsp70 complexes. Further improvements to the immunogenicity of the peptide were obtained by replacing the L1 flexible linker with a 4 amino acid sequence (L2=FFRK) containing plausible proteasome and protease cleavage sites to optimize processing. ELISPOT and 51Cr release assays reveal that mice immunized with J1-L2-Ova:hsp70 complexes produce greater CD8+ T cell responses than mice immunized with Ova:hsp70 complexes. The potency of the J1-L2-Ova:hsp complex was further illustrated in a tumor rejection model where it was observed that mice immunized with J1-L2-Ova:hsp complex were better protected against a subcutaneous challenge of EG7 thymoma cells (which expresses MHC I:SIINFEKL) than Ova:hsp immunized mice. To determine if this technology is applicable to human systems, three human melanoma epitopes (IMD: IMDQVPFSV; YMD: YMDGTMSQV; Trp2: SVYDFFVWL) were engineered with the N-terminal Javelin-linker and tested in mice that express the human HLA-A2 class I molecule. As determined by ELISPOT analysis, antigen-specific IFNγ production was observed in mice immunized with hsp70 complexed with each of the melanoma epitopes linked to the Javelin sequence. wWeIn conclusion, these studies show that hybrid peptides containing an N-terminal Javelin and a cleavable linker can strongly enhance specific CD8+ T cell responses when chaperoned by hsp70, and can be used to induce powerful immunity to tumor antigens in the absence of conventional adjuvant.
AT2 receptor stimulation inhibits phosphate-induced vascular calcification
Authors: Masayoshi Kukida, Masaki Mogi, Harumi Kan-no, Kana Tsukuda, Hui-Yu Bai, Bao-Shuai Shan, Toshifumi Yamauchi, Akinori Higaki, Li-Juan Min, Jun Iwanami, Takafumi Okura, Jitsuo Higaki, Masatsugu Horiuchi
Journal: Kidney International (2018)