tbuckley/cabot-search huggingface dataset:
Abstract 95: Exercise Training Prevents Attenuation of Nrf2/ARE-Antioxidant Signaling in Aging Myocardium
Authors: Rajasekaran Namakkal Soorappan, Sellamuthu S Gounder, Snkaranarayanan Kannan, Dinesh Devdoss, Matthew A Firpo, Christoph Boehme, E. Dale Abel, John R Hoidal
Journal: Circulation Research (2012)

Background: Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in cardiomyocytes, which lead to contractile dysfunction and cardiac abnormalities. These conditions are prominent in elderly human patients with oxidative stress induced CVD due to impaired antioxidant defense. Inducible antioxidant pathways are regulated by nuclear erythroid 2 p45-related factor 2 (Nrf2) through antioxidant response cis-elements (AREs). We find that the Nrf2 levels are impaired in the aging heart. The purpose of this study was to investigate age-dependent regulation of Nrf2-antioxidant mechanisms and redox homeostasis in the heart. Methods: Age-matched wild-type (WT) and Nrf2-/- (KO) mice at 2 and &gt;20 months were subjected to endurance exercise stress (EES) and assessed the activation of Nrf2/ARE-dependent transcriptional mechanisms in the heart. Myocardial ROS was measured by electron paramagnetic resonance (EPR) analysis. Results: Our recent findings indicate that acute exercise stress (AES) activates Nrf2 signaling and promotes myocardial antioxidant function in the young (∼2 months) mouse. Whereas aging mice (&gt;20 months) exhibit significant (p&lt;0.05) oxidative stress as compared to hearts of the young. Though aged-mice are highly susceptible to develop oxidative stress (OS) on endurance exercise stress (EES), they slowly become adaptive to maintain redox homeostasis after moderate exercise training (MET; 10-12m/min, for 45 min/day) for ∼6 weeks. While transcription and protein levels for most of the ARE-antioxidants were increased (p&lt;0.05) in young mice, their induction was blunted in aging mice on EES. Taken together, age-related Nrf2 dysfunction exacerbates EES mediated oxidative stress, which is likely to increase the vulnerability of the aging heart to develop hypertension and pressure overload type of diseases. Of note, a 6-weeks of chronic MET promoted nuclear translocation of Nrf2 along with its target antioxidants in the aging heart to near normal levels seen in young mice. Conclusions: These observations emphasize the importance of enhancing the Nrf2 function and endogenous cytoprotective mechanisms to combat age-induced ROS/RNS and protecting myocardium from oxidative stress diseases.
The <scp>EV</scp> erT2 (Effective Verruca Treatments 2) trial: a randomized controlled trial of needling vs. nonsurgical debridement for the treatment of plantar verrucae
Authors: F. Hashmi, C. Fairhurst, S. Cockayne, M. Cullen, K. Bell, E. Coleman, M. Harrison‐Blount, D. Torgerson
Journal: British Journal of Dermatology (2017)

Verrucae are a common foot skin pathology, which can in some cases persist for many years. Plantar verrucae can be unsightly and painful. There are a range of treatment options including needling.The EVerT2 (Effective Verruca Treatments 2) trial aimed to evaluate the clinical and cost-effectiveness of the needling procedure for the treatment of plantar verrucae, relative to callus debridement.This single-centre randomized controlled trial recruited 60 participants (aged ≥ 18 years with a plantar verruca). Participants were randomized 1 : 1 to the intervention group (needling) or the control group (debridement of the overlying callus). The primary outcome was clearance of the index verruca at 12 weeks after randomization. Secondary outcomes included recurrence of the verruca, clearance of all verrucae, number of verrucae, size of the index verruca, pain and participant satisfaction at 12 and 24 weeks. A cost-effectiveness analysis was carried out from the National Health Service perspective over 12 weeks.Sixty eligible patients were randomized (needling group n = 29, 48%; debridement group n = 31, 52%) and 53 were included in the primary analysis (needling n = 28, 97%; debridement n = 25, 81%). Clearance of the index verruca occurred in eight (15%) participants (needling n = 4, 14%; debridement n = 4, 16%; P = 0·86). The needling intervention costs were on average £14·33 (95% confidence interval 5·32-23·35) more per patient than for debridement.There is no evidence that the needling technique is more clinically or cost-effective than callus debridement. The results show a significant improvement in pain outcomes after needling compared with the debridement treatment alone.
Allogeneic Tcrα/β Deficient CAR T-Cells Targeting CD123 Prolong Overall Survival of AML Patient-Derived Xenografts
Authors: Monica L. Guzman, Mayumi Sugita, Hongliang Zong, Nathan Ewing-Crystal, Vicenta Trujillo-Alonso, Nuria Mencia-Trinchant, Linda Lam, Nicole M. Cruz, Roman Galetto, Agnès Gouble, Duane C Hassane, Julianne Smith, Gail J. Roboz
Journal: Blood (2016)
Is there a role for flexible sigmoidoscopy in polyp surveillance?
Authors: G Lawlor, N Aucharaz, S Sengupta, J Leyden, J Crowe, JR Lennon, E Clarke, P Mac Mathuna
Journal: Endoscopy (2006)

Aims: The prevalence of significant neoplasia in the proximal and distal colon varies widely in published series. FS is a quick, cheap and safe alternative to FC. In this study we investigated whether FS is a safe polyp surveillance option in a subset of individuals following the initial clearance FC.
Observation as the initial management strategy in patients with mantle cell lymphoma
Authors: P. Abrisqueta, D.W. Scott, G.W. Slack, C. Steidl, A. Mottok, R.D. Gascoyne, J.M. Connors, L.H. Sehn, K.J. Savage, A.S. Gerrie, D. Villa
Journal: Annals of Oncology (2017)
Community-associated methicillin-resistant Staphylococcus aureus ST8 ("USA300") in an HIV-positive patient in Cologne, Germany, February 2008
Authors: W Witte, C Braulke, B Strommenger
Journal: Eurosurveillance (2008)

The first cases of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) were reported in 1996 in Minnesota, United States (US) and were deep-seated skin and soft tissue infections and a few cases of necrotising pneumonia, mainly in children and among the Native American population [1]. A few years later, a large outbreak of CA-MRSA infections was reported in the men who have sex with men (MSM) community in California, predominantly among human immunodeficiency virus (HIV)-positive patients; data on sexual transmission was not available [2]. A recent report on the spread of CA-MRSA, mainly due to the widely disseminated strain ""USA300"", in numerous MSM in San Francisco and in one patient in Boston suggested sexual transmission [3], but initiated critical reviews concerning the transmission route and the corresponding public health message [4,5].
Is Complete Mucosal Recovery Necessary in Coeliac Disease?
Authors: A Murdock, SD Johnston, P Watson
Journal: Endoscopy (2006)

Aims: Gluten exclusion promotes mucosal normalisation in coeliac disease with the assumption that full mucosal recovery is a requirement for a full quality of life. This study looks at duodenal mucosa after treatment with a gluten free diet for at least tens years in a group of patients who are symptom free.
Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients
Authors: Charles Langelier, Matt S. Zinter, Katrina Kalantar, Gregory A. Yanik, Stephanie Christenson, Brian O’Donovan, Corin White, Michael Wilson, Anil Sapru, Christopher C. Dvorak, Steve Miller, Charles Y. Chiu, Joseph L. DeRisi
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

BACKGROUND: Lower respiratory tract infections (LRTI) are a leading cause of mortality in hematopoietic cell transplant (HCT) recipients. Current microbiologic diagnostics often fail to identify etiologic pathogens, leading to diagnostic uncertainty and precluding the implementation of targeted therapies. To directly address the need for improved LRTI diagnostics, we undertook this study to evaluate the potential utility of metagenomic next generation sequencing (mNGS) approaches for detecting LRTI in the HCT population.  METHODS: We enrolled 22 post-HCT adults ages 19-69 years with acute respiratory illnesses who underwent bronchoalveolar lavage (BAL) at the University of Michigan between January 2012 and May 2013. Unbiased mNGS was performed on BAL fluid to detect microbes and assess host response. Results were compared to those obtained by standard clinical microbiology testing.  RESULTS: Unbiased mNGS detected all microbes identified by standard testing (human metapneumovirus, respiratory syncytial virus, Stenotrophomonas maltophilia, human herpesvirus 6 and cytomegalovirus).  Previously unrecognized LRTI pathogens were identified in six patients for whom standard testing was negative (human coronavirus 229E, human rhinovirus A, Corynebacterium propinquum and Streptococcus mitis) and findings were confirmed by independent PCR testing. mNGS identified microbes of unlikely or uncertain pathogenicity in 10 patients with clinical evidence of non-infectious respiratory conditions. Patients with respiratory pathogens were found to have significantly increased expression of immunity related gene biomarkers relative to those without (p=0.022) as well as lower alpha diversity of their respiratory microbial communities (p=0.017).  CONCLUSIONS: Compared to conventional diagnostics, host/pathogen mNGS enhanced detection of microbial pathogens in BAL fluid from HCT patients.  Furthermore, this approach simultaneously evaluated the association between identified microbes and the expression of innate immunity gene biomarkers. Host/pathogen mNGS holds promise for precision diagnosis of post-HCT respiratory infection.
Assessment of a Person-Level Risk Calculator to Predict New-Onset Bipolar Spectrum Disorder in Youth at Familial Risk
Authors: Danella M. Hafeman, John Merranko, Tina R. Goldstein, David Axelson, Benjamin I. Goldstein, Kelly Monk, Mary Beth Hickey, Dara Sakolsky, Rasim Diler, Satish Iyengar, David A. Brent, David J. Kupfer, Michael W. Kattan, Boris Birmaher
Journal: JAMA Psychiatry (2017)

<h3>Importance</h3> Early identification of individuals at high risk for the onset of bipolar spectrum disorder (BPSD) is key from both a clinical and research perspective. While previous work has identified the presence of a bipolar prodrome, the predictive implications for the individual have not been assessed, to date. <h3>Objective</h3> To build a risk calculator to predict the 5-year onset of BPSD in youth at familial risk for BPSD. <h3>Design, Setting, and Participants</h3> The Pittsburgh Bipolar Offspring Study is an ongoing community-based longitudinal cohort investigation of offspring of parents with bipolar I or II (and community controls), recruited between November 2001 and July 2007, with a median follow-up period of more than 9 years. Recruitment has ended, but follow-up is ongoing. The present analysis included offspring of parents with bipolar I or II (aged 6-17 years) who had not yet developed BPSD at baseline. <h3>Main Outcomes and Measures</h3> This study tested the degree to which a time-to-event model, including measures of mood and anxiety, general psychosocial functioning, age at mood disorder onset in the bipolar parent, and age at each visit, predicted new-onset BPSD. To fully use longitudinal data, the study assessed each visit separately, clustering within individuals. Discrimination was measured using the time-dependent area under the curve (AUC), predicting 5-year risk; internal validation was performed using 1000 bootstrapped resamples. Calibration was assessed by comparing observed vs predicted probability of new-onset BPSD. <h3>Results</h3> There were 412 at-risk offspring (202 [49.0%] female), with a mean (SD) visit age of 12.0 (3.5) years and a mean (SD) age at new-onset BPSD of 14.2 (4.5) years. Among them, 54 (13.1%) developed BPSD during follow-up (18 with BD I or II); these participants contributed a total of 1058 visits, 67 (6.3%) of which preceded new-onset BPSD within the next 5 years. Using internal validation to account for overfitting, the model provided good discrimination between converting vs nonconverting visits (AUC, 0.76; bootstrapped 95% CI, 0.71-0.82). Important univariate predictors of outcome (AUC range, 0.66-0.70) were dimensional measures of mania, depression, anxiety, and mood lability; psychosocial functioning; and parental age at mood disorder. <h3>Conclusions and Relevance</h3> This risk calculator provides a practical tool for assessing the probability that a youth at familial risk for BPSD will develop new-onset BPSD within the next 5 years. Such a tool may be used by clinicians to inform frequency of monitoring and treatment options and for research studies to better identify potential participants at ultra high risk of conversion.
Linker proteins restore basement membrane and correct <i>LAMA2</i> -related muscular dystrophy in mice
Authors: Judith R. Reinhard, Shuo Lin, Karen K. McKee, Sarina Meinen, Stephanie C. Crosson, Maurizio Sury, Samantha Hobbs, Geraldine Maier, Peter D. Yurchenco, Markus A. Rüegg
Journal: Science Translational Medicine (2017)

Transgenic expression of two small linker proteins restores muscle function and prolongs life span in a mouse model of LAMA2 -related muscular dystrophy.
A randomized trial of FOLFIRI versus docetaxel and cisplatin as a second-line chemotherapy after failure of first-line chemotherapy in advanced gastric cancer
Authors: Kil Lee Sang, Seok Moon Hee, Eun Kim Sung, seok jang jin, Young Cho Joo, Sun Kim Eun, Hyung Lee Si, Chul Park Jun, Kang Lee Yong
Journal: Annals of Oncology (2017)
Global ph 3, randomized, double-blind, placebo-controlled study of PEGylated recombinant human hyaluronidase PH20 (PEGPH20) + nab-paclitaxel &amp; gemcitabine in pts with previously untreated, hyaluronan-high, stage iv pancreatic ductal adenocarcinoma
Authors: Eric Van Cutsem, Andrew Hendifar, Michele Reni, Lei Zheng, Michel Ducreux, William Harris, Pippa Corrie, Tara Seery, Dimitrios Chondros, Andrea Bullock
Journal: Annals of Oncology (2017)
Nephroblastoma: Management challenges and outcome in a resource-poor country.
Authors: Lofty-John Chukwuemeka Anyanwu, Aminu Mohammad, Lawal Abdullahi, Aliyu Farinyaro
Journal: Journal of Clinical Oncology (2014)

e21008 Background: Nephroblastoma is the most common renal malignant tumor of childhood, and represents approximately 6% of all childhood cancers. Its management can be challenging in resource poor settings. We report the characteristics and treatment outcomes of children presenting with this tumor to our unit. Methods: The records of 25 patients managed for Nephroblastoma between June 2008 and December 2013 in our unit were retrospectively reviewed. The diagnosis was based on physical examination, abdominal ultrasonography and intravenous urography. Chest X-ray was done to rule out pulmonary metastasis. Results: The median age was 4 years (range 6 months- 12 years). There were 15 boys and 10 girls (F:M = 1:1.5). Abdominal mass was the most common presenting symptom (24/25; 96%). The tumors were left sided in 15 patients (15/25; 60%), right sided in 9 patients (9/25; 36%), and bilateral in one patient (1/25; 4%). Treatment was according to SIOP-9 protocol, however only 3 patients with recurrent disease were referred for radiotherapy. Majority of the patients (16/25; 64%) presented with a stage III disease. Six patients died during the course of treatment, 10 were lost to follow up before completion of their treatment, and two relapsed after completion of their treatment. The longest duration of follow up was 4 years. Conclusions: Resource constraint is a major challenge in the management of childhood tumors in developing countries.
Liquid Marbles: Transparent and Gas-Permeable Liquid Marbles for Culturing and Drug Sensitivity Test of Tumor Spheroids (Adv. Healthcare Mater. 13/2017)
Authors: Hualin Li, Peng Liu, Guneet Kaur, Xi Yao, Mengsu Yang
Journal: Advanced Healthcare Materials (2017)

Xi Yao, Mengsu Yang, and co-workers prepare transparent nanoparticle-based liquid marbles for culturing tumor spheroids in 3D in article number 1700185. The formation of spheroids from a population of cancer cells or a single cell in the transparent liquid marbles can be optically recorded continuously. Tumor spheroids cultured in the liquid marbles show enhanced viability under the treatment of chemotherapeutic drugs and small interfering RNA.
Pharyngeal swallowing and oesophageal motility during a solid meal test: a prospective study in healthy volunteers and patients with major motility disorders
Authors: Michael Hollenstein, Philip Thwaites, Simon Bütikofer, Henriette Heinrich, Matthias Sauter, Irina Ulmer, Daniel Pohl, Daphne Ang, Daniel Eberli, Werner Schwizer, Michael Fried, Oliver Distler, Mark Fox, Benjamin Misselwitz
Journal: The Lancet. Gastroenterology & hepatology (2017)
Gastric Gastrointestial Stromal Tumours (GIST's): A Review of 16 Cases
Authors: S Rowley, E Gaffney, N Ravi, J Reynolds
Journal: Endoscopy (2006)

Aim and Methods: Gastrointestinal Stromal tumours (GIST's) are the most common mesenchymal tumours of the gastrointestinal tract. Approximately, two-thirds are located in the stomach. Clinical, pathological and management details of 16 gastric GIST's from 1998 to date were retrospectively analysed in this study.
Drugs for poor sleepers?: Author's reply
Authors: I. Oswald
Journal: BMJ (1986)

MAy 1986 identical value.Hence, even if HDL cholesterol were of no relevance whatever to coronary heart disease-that is, if non-HDL cholesterol were the only thing that mattered-and if the two types of cholesterol were entirely uncorrelated with each other, then one would still find that, among people with the same total cholesterol, HDL cholesterol would tend to be inversely correlated with coronary heart disease, simply because low HDL cholesterol would then be an indicator of high non-HDL cholesterol.Thus, the chief question of interest is whether, given non-HDL
CAL2 Monoclonal Antibody Is a Rapid and Sensitive Assay for the Detection of Calreticulin Mutations in Essential Thrombocythemia and May Provide Prognostic Informations
Authors: Massimiliano Bonifacio, Rachele Montemezzi, Alice Parisi, Giovanna De Matteis, Luigi Scaffidi, Giuseppe Lippi, Marco Chilosi, Giovanni Pizzolo, Mauro Krampera, Achille Ambrosetti
Journal: Blood (2016)
Is it possible to stop radiographic progression with conventional treatment in early rheumatoid arthritis?: 2 years results from the CIMESTRA study
Authors: ML Hetland, M Østergaard, A Vestergaard, A Jurik, K Stengaard-Pedersen, Peter Junker, Tine Lottenburger, I Hansen, LS Andersen, U Tarp, H Skjødt, J Pedersen, O Majgaard, Anders Jørgen Svendsen, T Ellingsen, G Hansen, Hanne Merete Lindegaard, Kim Hørslev-Petersen
Journal: Annals of the Rheumatic Diseases (2007)
Whole Genome Sequencing of Unique Paired SMM/MGUS Progressing to MM Samples Reveals a Genomic Landscape with Diverse Evolutionary Pattern
Authors: Niccolo Bolli, Francesco Maura, Stephane Minvielle, Dominik Gloznik, Raphael Szalat, Anthony Fullam, Mehmet Kemal Samur, Patrick Tarpey, Helen Davies, Inigo Martincorena, Kevin J. Dawson, Thomas Mitchell, Jorge Zamora, Cristiana Carniti, Yu-Tsu Tai, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Carl Anderson, David Wedge, Herve Avet-Loiseau, Peter Campbell, Nikhil Munshi
Journal: Blood (2016)
Differential gene profiling of malignant cells and fibroblasts from the primary and metastatic sites from breast cancer patients upon stroma-epithelial cell interaction
Authors: M. A. Koike Folgueira, S. T. Honda, T. T. Benvenuti, P. B. Rozenchan, R. P. Santos, H. Brentani, D. M. Carraro, M. H. Katayama, E. C. Lyra, M. M. Brentani
Journal: Journal of Clinical Oncology (2006)

10570 Background: In breast cancer (BC), stromal-epithelial cell interactions may influence tumor development in the primary tumor (PT) and metastatic sites, which may be reflected by a differential phenotype of malignant cells and fibroblasts (Fb). Methods: To investigate the role of stromal cell interactions in tumor development in the primary site and in lymph nodes (LN), primary culture of Fb obtained from breast tissue: PT (n = 4) or peritumoral (n = 4); and LN: involved (iLN, n = 3) or uninvolved (n = 3) from BC patients, were established. Fb and normal (MCF10A) or malignant breast cells (MDA-MB231) were cultured isolated or co-cultured separated by a porous membrane, for diffusion of soluble factors. Gene profile of epithelial cells or Fb were analyzed separately in cDNA microarray slides. Gene expression of co-cultured cells were compared to that of cells cultured alone and differentially expressed genes were those satisfying a FDR &lt;0.01 and &gt; 2 fold variation. Genes exclusively regulated during malignant conditions (MDA-MB231 cells co-cultured with Fb from PT or iLN) were selected on Venn diagrams. Results: Gene profile from MDA-MB231 cells may be influenced by Fb from the PT as 74 genes were differentially expressed upon co-culture as compared to MDA-MB231 cells maintained alone, including genes involved in DNA metabolism and regulation of transcription. Ninety nine genes were modulated in MDA-MB231 cells co-cultured with Fb from iLN, as those involved in RNA metabolism, phosphate metabolism and protein catabolism. Only 2 genes were commonly down-regulated in malignant cells upon co-culture with Fb from PT and iLN, KATNB1 and ZNF19, which modulation seem important for tumor development in both sites. In addition, malignant cells differentially affect gene expression of Fb from PT or iLN. Conclusions: Upon co-culture between Fb obtained from PT and iLN with malignant cells, a reciprocal regulation of a differential group of genes was observed, which may be important for tumor development in these different sites. This model may allow identification of candidate genes involved in stromal-cell interactions during tumor development in PT or LN. Supported by FAPESP and CNPQ. No significant financial relationships to disclose.
Role of Topical Antibiotics in the Prevention of Poatappendectomy Wound Infection
Authors: A Ghallab, S Ahmad, Y Abdeldaim, M Tabbassum, P Magill
Journal: Endoscopy (2006)

Aims: Despite improved asepsis and surgical techniques, postoperative wound infection still accounts for a significant morbidity. Studies showed that antibiotics reduce the risk of postappendectomy wound infection. Our aim was to determine role of topical antibiotic in reducing postappendectomy wound infection.