tbuckley/cabot-search huggingface dataset:
Ischemic Postconditioning During Primary Percutaneous Coronary Intervention: Is Smoker’s Paradox in Play?
Authors: Oladipupo Olafiranye
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Graft Purity and Composition Significantly Impact the Engraftment of Autologous Stem Cell Transplants
Authors: Valentina Giai, Stefania Tamiazzo, Sabrina Leoncino, Lia Mele, Maria Matilde Ciriello, Federico Monaco, Elisa Bernocco, Alessandro Levis, Roberto Guaschino, Massimo Pini, Franco Maria Dallavalle, Marco Ladetto
Journal: Blood (2016)
Shining (Laser) Light on Traumatic Brain Injury Blood Biomarkers
Authors: Lee E. Goldstein, Ann C. McKee
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Monitoring player fatigue status in the English Premier League
Authors: Robin T Thorpe
Journal: British Journal of Sports Medicine (2017)

As a ‘real-world’, coach/management-directed question, my aim was to establish the ‘performance readiness’ of players competing in the English Premier League (EPL) in attempt to reduce injury/illness risk and maximise player availability and performance. The primary focus of my thesis was to evaluate potential indicators of fatigue which may be easily monitored and used in an EPL environment. My first study established the reliability of such parameters, and second, third and fourth investigations explored the sensitivity to changes in daily and acute training load and during typical competitive weeks, respectively.

The acute and chronic physical demands of football players competing in the EPL have significantly increased in recent years.1 Consequently, adapting training load prescription and maximising recovery interventions for players may contribute to reducing injury and illness risk and even enhance physical and mental performance.2 Therefore, evaluation and quantification of player physiological/fatigue response may provide beneficial information to key stakeholders …
Integration Of Gwas, eQTL, And Encode Data Identify Regulatory Variants And Cell Types Contributing To Patterns Of Radiographic Emphysema
Authors: P Castaldi, Rsj Estepar, MH Cho, W Qiu, P Bakke, A Gulsvik, DA Lomas, J Crapo, T Beaty, SI Rennard, D Singh, R Tal-Singer, JH Riley, GR Washko, BA Raby, Carey, EK Silverman, CP Hersh
Journal: American Journal of Respiratory and Critical Care Medicine (2014)
Abstract 197: Plasminogen Is Required for Hematopoietic Stem Cell-Mediated Cardiac Repair After Myocardial Infarction
Authors: Yanqing Gong, Ying Li, Jane Hoover-Plow
Journal: Circulation Research (2012)

Myocardial infarction (MI) is the primary cause of death throughout the United States. Granulocyte colony-stimulating factor (G-CSF) is used to mobilize hematopoietic progenitor and stem cells (HPSC) to improve cardiac recovery after MI. However, poor-mobilization to G-CSF is observed in 25% of patients and 10-20% of healthy donors. Therefore, a better understanding of the underlying mechanisms may offer novel approaches for G-CSF-mediated therapeutics. Our previous studies have identified an essential role of Plg in HPSC mobilization from bone marrow (BM) in response to G-CSF. Here, we investigate the role of Plg in G-CSF-stimulated cardiac repair after MI. Our data show that G-CSF significantly improves cardiac repair including increasing neovascularization in the infarct area, and improving ejection fraction and LV internal diameter determined by echocardiogram in WT mice. No improvement on heart function is observed in Plg -/- mice, indicating Plg is required for G-CSF-regulated cardiac repair after MI. To investigate whether Plg regulates HPSC recruitment to the ischemic area, BM transplantation with EGFP-expressing BM cells was performed to visualize BM-derived stem cells in infarcted tissue. Our data show that G-CSF dramatically increases recruitment of GFP + cKit + cells (by 12 fold) in WT mice but not in Plg -/- mice. In addition, BM stem cell-derived vessels and arteries are infrequent in Plg -/- mice suggesting that Plg enhances cardiac repair by promoting stem cell recruitment to the lesion. In further studies, we investigated the role of Plg in the regulation of SDF-1/CXCR-4 axis, a major regulator for HPSC recruitment. Our results show that G-CSF significantly increases CXCR-4 expression in the infarcted area in WT mice. While G-CSF-induced CXCR-4 expression is markedly decreased (80%) in Plg -/- mice, suggesting Plg may regulate CXCR-4 expression during HSPC recruitment to injured heart. Interestingly, Plg does not affect SDF-1 expression in response to G-CSF treatment. Taken together, our findings have identified a critical role of Plg in HSPC recruitment to the lesion site and subsequent tissue repair after MI. Thus, targeting Plg may offer a new therapeutic strategy to improve G-CSF-mediated cardiac repair after MI.
Reversal of Glanzmann's Thrombasthenia &amp; Glycoprotein IIb/Iiia Antagonists by Combined Haemostatic Intervention with Fibrinogen Concentrate and Recombinant Factor VIIa.
Authors: Gayathri Murali-Krishnan, David Bevan, Aine McCormick, Savita Rangarajan, Benny Sørensen
Journal: Blood (2009)
Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells
Authors: N Shenoy, T Bhagat, E Nieves, M Stenson, J Lawson, G S Choudhary, T Habermann, G Nowakowski, R Singh, X Wu, A Verma, T E Witzig
Journal: Blood Cancer Journal (2017)

The Ten Eleven Translocation (TET) enzymes have been found to be mutated in both diffuse large B-cell (DLBCL) and peripheral T-cell (PTCL) lymphomas resulting in DNA hypermethylation. Recent studies in embryonal stem cells showed that ascorbic acid (AA) is a cofactor for TET with a binding site at the catalytic domain, and enhances TET activity. We hypothesized that AA could potentially enhance TET activity in lymphoma cells to cause DNA demethylation, reactivate expression of tumor suppressor genes and enhance chemosensitivity. We demonstrate in vitro that AA treatment of DLBCL and PTCL cells using AA concentrations achievable intravenously increased TET activity leading to DNA demethylation. This epigenetic effect is independent of hydrogen peroxide. AA treatment increased the expression of SMAD1, a tumor suppressor gene known to be suppressed by methylation, and increased chemosensitivity of lymphoma cells. Twenty-nine percent (10/34) of unselected lymphoma patients had plasma AA levels that were deficient suggesting an additional clinical mechanism of TET hypofunction. These data indicate that AA has the potential to modify TET function in lymphoma and enhance chemosensitivity. In addition, the AA deficiency seen in some patients may further impair TET function and contribute to resistance. Clinical trials testing intravenous AA with chemotherapy are warranted.
Randomized trial of exercise vs. usual care on cancer biomarkers in ovarian cancer survivors: The Women’s Activity and Lifestyle Study in Connecticut (WALC).
Authors: Brenda Cartmel, Yang Zhou, Linda Gottlieb, Fangyong Li, Elizabeth A Ercolano, Maura Harrigan, Ruth McCorkle, Jennifer A. Ligibel, Radhika Gogoi, Peter E. Schwartz, Harvey A Risch, Melinda L Irwin
Journal: Journal of Clinical Oncology (2016)

5561 Background: Physical activity (PA) has been associated with a lower risk of developing or dying of many cancers, including ovarian cancer (OC). Inflammatory and metabolic pathways may underlie these associations. We examined the effect of exercise (EX) vs. attention control (AC) on insulin, insulin-like growth factor (IGF)-I, leptin, adiponectin, C-reactive protein (CRP), TNF-α, and IL-6 in women with OC. Methods: We randomized 144 inactive, post-chemotherapy OC survivors into a 6-month (6M) RCT of EX vs. AC; blood samples were available on a subgroup EX (n=53) vs. AC (n=51). All women received weekly phone calls; those in the EX arm were counseled on increasing their PA to 150 min/wk of aerobic exercise and those in the AC arm given information on health topics. Fasting blood samples were drawn at baseline (BL) and 6M. Biomarkers were assayed by ELISA, auto analyzer or RIA. Mixed model repeated analysis was used to compare BL to 6M changes in biomarkers, and included adjustment for BL biomarker levels, study sites, prior recurrence and treatment. Results: At BL women were 1.6 ± 1.0 (mean + SE) yrs post-diagnosis, 52% stage III-IV, 57 ± 9 years old, and exercised 31 ± 46 mins/wk. At 6M women in the EX arm did 176± 64 min/wk of exercise, predominately walking. Significant between-group differences were observed for BL to 6M changes in leptin and IGF-1 (Table). Conclusions: 6M of PA led to a 27% and 15% decrease in leptin and IGF-1 respectively. The impact of exercise and these biomarkers on OC prognosis remains to be determined. Clinical trial information: NCT02107066.Effect of EX vs. AC on BL to 6M changes in biomarkers (mean (SE)). BL Change (6M-BL) EX AC p-value EX AC p-value IGF-1 (ng/ml) 90.9 (5.5) 77.7 (4.8) 0.07 -10.1 (4.30) 3.58 (4.59) 0.02 Leptin (ng/ml) 30.9 (4.4) 36.0 (2.9) 0.34 -4.47 (2.74) 4.56 (2.90) 0.02 Adiponectin (µg/ml) 17.4 (1.3) 16.9 (1.4) 0.80 -0.82 (1.03) -0.64 (1.09) 0.90 CRP (mg/L) 4.37 (0.8) 5.96 (1.4) 0.32 -0.31 (1.12) -0.49 (1.17) 0.90 IL-6 (pg/ml) 2.06 (0.2) 2.21 (0.2) 0.64 0.18 (0.36) 0.11 (0.38) 0.89 Insulin (µU/ml) 13.2 (1.2) 16.4 (1.6) 0.11 1.43 (1.54) 3.42 (1.65) 0.39 TNFα (pg/ml) 1.06 (0.04) 1.24 (0.1) 0.03 0.04 (0.05) 0.01 (0.05) 0.56
Abstract 221: Chronic Alterations of the Tissue Dendritic Cell and Macrophage Network Underlies the Th1 Response in the Failing Heart
Authors: Mohamed Ameen Ismahil, Justin R Kingery, Tariq Hamid, Guihua Zhou, Shangzhi Guo, Sumanth D Prabhu
Journal: Circulation Research (2012)

Little is known about changes in the immune cell network that underlie pro-inflammatory cytokine elaboration in chronic heart failure (HF). Dendritic cells (DCs) and macrophages are antigen-presenting cells that play a central role in inflammation and immune tolerance. We investigated the pattern of infiltrating cardiac DCs and macrophages in chronic post-ischemic HF. Myocardial infarction (MI) was induced by left coronary ligation in male C57BL/6 mice. Pathological remodeling and HF were confirmed by hemodynamics, gravimetry, and echocardiography at 8 weeks post-MI. Sham-operated mice served as controls. At 8 weeks, cardiac infiltrating immune cells were isolated by collagenase digestion followed by density gradient centrifugation. Trypan blue-negative viable cells were quantified using flow cytometry. DCs were characterized using specific markers for classical (cDC) (CD11C+B220-), plasmacytoid (pDC) (CD11C+B220+), and immunogenic (CD11c+B220+CD86hi) and tolerogenic (CD11c+B220+CD86low) DCs. Macrophages were classified as activated (CD11b+F480+), pro- or anti-inflammatory (CD11b+F480+Gr1hi or low), and M1 (CD11b+F480+CD206-) or M2 (CD11b+F480+CD206+). Significant increases in cDCs (1.4 fold; p=0.016) and pDCs (4.3 fold; p=0.0016) were observed in failing myocardium. Surface expression of the maturation marker CD86 was increased 8.6 fold (p=0.009), whereas immature DCs exhibited a robust 24.4 fold (p=0.0005) increase. Activated macrophages were also significantly elevated in the failing heart as compared with sham-operated hearts (19.2 ± 1.9 vs 10.9 ± 2.9%; p=0.033), with marked infiltration of pro-inflammatory and M1 macrophages (6.2 ± 0.6 vs 3.8 ± 0.7%; p=0.019). In contrast, levels of anti-inflammatory and M2 macrophages were unchanged. We conclude that in chronic HF, there is marked upregulation of cDC and pDC subsets and pro-inflammatory/M1 macrophages that alter immune homeostasis, contribute to the recruitment and activation of immune cells, and underlie the chronic Th1 response in failing myocardium that promotes pathological remodeling. This suggests that targeting or altering immune cell subsets in the failing heart, rather than specific cytokines, may be a better approach to modulating inflammation in HF.
Pancreatic Ductal Adenocarcinoma With High Radiotracer Uptake in 68Ga–Prostate-Specific Membrane Antigen PET/CT
Authors: Samine Sahbai, Petra Rieping, Christina Pfannenberg, Christian la Fougére, Matthias Reimold
Journal: Clinical Nuclear Medicine (2017)

Prostate-specific membrane antigen imaging with PET/CT is increasingly used in prostate cancer and was shown to have a high diagnostic performance. We report a clinical case of a 67-year-old man with previous history of operated prostate cancer and increasing prostate-specific antigen blood level. Ga-HBED-CC prostate-specific membrane antigen PET/CT imaging was indicated for the assessment of local recurrence and lymph node metastases of prostate cancer. In addition, a soft tissue mass in the body of the pancreas with high radiotracer uptake was detected. Histopathology confirmed a pancreatic ductal adenocarcinoma.
Transitional cell cancer of the renal pelvis: Impact of surgery and radiation on survival—A population-based study.
Authors: Vaibhav Verma, Gurinder Singh Sidhu, Amarpali Brar, Geeti Sharma, Nikhil Mukhi, Henry Vuong
Journal: Journal of Clinical Oncology (2014)

e15622 Background: Transitional cell cancer (TCC) of renal pelvis (RP) is an uncommon malignancy of the urinary tract. The standard of treatment is radical nephro-uretrectomy (NU) with bladder cuff resection whereas lesser extensive surgeries with renal preservation are recommended for situations like solitary kidney, bilateral disease, or renal insufficiency. Role of radiation is unclear. Methods: We reviewed data from Surveillance, Epidemiology, and End Results (SEER) Data registry for patients with TCC of RP from 1973 to 2010. Results: Records of 13250 patients were reviewed. Ninety percent of patients were white and 4.6 black. Males constituted 41% of the patients, 59% were female. Median age of diagnosis was 75-79 years. In patients with known surgery type (6170), 57% had NU and 43% had less radical surgeries (radical/partial nephrectomy or ureterectomy); mean survival in patients undergoing NU and less radical surgeries was 115 and 101 months, respectively. Using the chi square log rank analysis, the p value was less than 0.001. In 4589 patients, complete staging data was available; and stage 1,2,3 and 4 disease was noted in 29, 12, 30 and 29 % patients respectively. Mean survival in stage 1,2,3,4 was 75, 71, 63 and 30 months respectively (p<0.001). Mean survival (months) in patient who underwent NU as compared to less extensive surgeries in each stage were: Stage 1- 77 vs 75 (p− 0.481), Stage 2− 68 vs 72 (p−0.671), Stage 3− 64 vs 61 (p−0.142) , Stage 4−37 vs 32 (p−0.001). Radiation therapy was used after surgery in 785 patients, mostly in advanced stage disease, and it made no impact on survival. Conclusions: TCC of RP is a disease of the elderly with slight female predominance. NU is superior to less extensive surgery. Advanced stage is associated with poorer outcome. There is no advantage of adjuvant radiation therapy in our analysis.
Efficacy of Over-the-Scope Clips in Management of High-Risk Gastrointestinal Bleeding
Authors: Justin Brandler, Anushka Baruah, Muhammad Zeb, Ayesha Mehfooz, Prachi Pophali, Louis Wong Kee Song, Barham AbuDayyeh, Christopher Gostout, Kristin Mara, Ross Dierkhising, Navtej Buttar
Journal: Clinical Gastroenterology and Hepatology (2017)
Preventing Fat Gain by Blocking Follicle-Stimulating Hormone
Authors: Wendy M. Kohrt, Margaret E. Wierman
Journal: New England Journal of Medicine (2017)

The level of circulating follicle-stimulating hormone (FSH) increases in women after menopause. A recent study in mouse models showed that FSH binds to its receptor on white adipocytes and results in a relatively low resting energy expenditure and increased adiposity.
Abstract 328: Effects of Sympatho-excitation on Directional Anisotropy in Ventricular Myocardium
Authors: Olujimi A Ajijola, Anadjeet Khahera, Eric Aliotta, Oh Jin Kwon, Keijiro Nakamura, Tadanobu Irie, Daniel B Ennis, Kalyanam Shivkumar
Journal: Circulation Research (2015)

Introduction: Control of electrical propagation exerted by the sympathetic nervous system is has not been quantified in-depth. Methods: High-resolution mapping (64-electrode plaque, 8x8, 1.96cm 2 ) of the anterior LV myocardium in porcine model (n=6) was performed before &amp; during left stellate ganglion stimulation (LSGS). Activation times (AT), activation recovery intervals (ARIs), conduction velocities (CV), and CV anisotropy were obtained during pacing. Ex vivo diffusion tensor MRI and histology were performed to define myocardial fiber orientation in the mapped regions. Results: LSGS shortened ARI (314.3±7.8ms vs. 287.8±6.6ms, p&lt;0.001). At baseline, longitudinal CV (CV L ) was greater than transverse CV (CV T ) (1.2±0.2m/s vs 0.7±0.1m/s, p&lt;0.001). LSGS did not increase CV L (1.16±0.16m/s vs 1.17±0.15m/s, p=0.2), or CV T (0.67±0.07m/s vs 0.7±0.04m/s, p=0.2). However, CV in the retrograde direction along fiber orientation was significantly increased by LSGS (0.7±0.05m/s vs 0.9±0.06m/s, p&lt;0.01). This resulted in a significant reduction in directional anisotropy (CV antegrade /CV retrograde ) along fiber direction (1.6±0.3 vs 1.3±0.3, p&lt;0.001), but not CV L /CV T (1.78±0.2 vs. 1.66±0.2 for BL and LSGS, respectively, p&gt;0.2). Heterogeneity of activation (AT disp ) was greater in the transverse than longitudinal direction (20±2ms 2 /cm 2 vs. 13±1.5ms 2 /cm 2 , p= 0.022). LSGS decreased transverse AT disp to 18±1.8 ms 2 /cm 2 (p=0.015), but not longitudinal AT disp . Conclusion: Cardiac sympatho-excitation modulates CV and AT disp in a fiber orientation-dependent manner. These uneven changes may contribute to arrhythmogenic mechanisms seen during sympatho-excitation.
Case 22-2017
Authors: Jacqueline T. Chu, Rydhwana Hossain, Frederic J. Silverblatt, Emily P. Hyle, Sarah E. Turbett
Journal: New England Journal of Medicine (2017)

A 21-year-old woman presented with fevers, headache, and myalgias after returning from travel to Indonesia. She had pulmonary rales, abdominal tenderness, rash, and conjunctival injection. Hypoxemia and acute kidney injury developed. A diagnostic test was performed.
Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice
Authors: Fei Wang, Yasuo Okamoto, Isao Inoki, Kazuaki Yoshioka, Wa Du, Xun Qi, Noriko Takuwa, Koichi Gonda, Yasuhiko Yamamoto, Ryunosuke Ohkawa, Takumi Nishiuchi, Naotoshi Sugimoto, Yutaka Yatomi, Kunitoshi Mitsumori, Masahide Asano, Makoto Kinoshita, Yoh Takuwa
Journal: Journal of Clinical Investigation (2012)

All authors agree to retract the above article due to multiple use of the same images or manipulation of data in Figures 1A,2D, 5C, 6B, 6C, and 8A and Supplemental Figure 8E.They are also not able to provide some of the raw data that are used in Figures 2A,2B, 5, 6, 7C, 8, and 9C, Supplemental Tables 1234, and Supplemental Figures 2C,3, 4, 5, 7C, 8A-8C, 8E, 8F, 10A, and 10B.The first author, Fei Wang, has admitted his sole responsibility in altering figures.The authors apologize and deeply regret the impact of this action.However, the authors stand behind data showing that genetic deletion of S1pr2 or pharmacological S1PR2 inhibition alleviates atherosclerosis in Apoe -/-mice fed a high-cholesterol diet.
Assessing the Generalizability of the National Lung Screening Trial: Comparison of Patients with Stage 1 Disease
Authors: Nichole T. Tanner, Lin Dai, Brett C. Bade, Mulugeta Gebregziabher, Gerard A. Silvestri
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

The findings of the NLST (National Lung Screening Trial) are the basis for screening high-risk individuals according to age and smoking history. Although screening is covered for eligible Medicare beneficiaries, the generalizability of the NLST in the elderly population has been questioned.Compare outcomes of patients diagnosed with stage 1 non-small cell lung cancer in the NLST to a nationally representative cohort of elderly patients Methods: Analysis of Surveillance, Epidemiology, and End Results (SEER)-Medicare and NLST datasets for patients with stage 1 disease aged 65 to 74 years.Lung cancer-specific mortality, all-cause mortality, and 30-, 60-, and 90-day treatment mortality were measured. When compared with the NLST group undergoing surgery for stage 1 non-small cell lung cancer, those in the SEER-Medicare NLST eligible cohort had no difference in adjusted odds ratios for 30-, 60-, and 90-day surgical mortality (P values = 0.97, 0.65, and 0.46, respectively). Although the 5-year cancer-specific survival did not differ between cohorts (hazard ratio [HR], 0.84 NLST vs. SEER-Medicare NLST eligible; P = 0.21), the adjusted HR estimate for all-cause mortality was better in the NLST cohort (HR, 0.71; P < 0.01). For patients who did not receive surgery for early-stage disease (presumably for curative intent), the outcomes were far worse (13.1, 18.9, 23.9%, for 30-, 60-, and 90-day treatment mortality, respectively).Elderly patients with minimal comorbid conditions meeting the inclusion criteria of the NLST who underwent surgery had excellent postoperative outcomes and similar lung cancer-specific 5-year survivorship. In those with significant comorbidities or those not undergoing surgery, competing causes of death may diminish the benefit, and there is no evidence to recommend screening in this group.