Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis
Authors: Fernando Bril, Kenneth Cusi
Journal: Annals of Internal Medicine (2017)

Letters7 February 2017Long-Term Pioglitazone Treatment for Patients With Nonalcoholic SteatohepatitisFernando Bril, MD and Kenneth Cusi, MDFernando Bril, MDFrom University of Florida and Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida. and Kenneth Cusi, MDFrom University of Florida and Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0629 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Sutton and Dr. Thomas and colleagues for their interest in our work and for raising important issues that put its implications into perspective. Dr. Sutton has concerns that misinformation about potential adverse effects of pioglitazone by many health care providers (and patients), despite convincing evidence to the contrary, may lead to limited prescribing or poor adherence to therapy. This highlights the important role of clinicians to educate patients on the best available evidence so that shared decisions are based on outcomes and not perceptions. Still, many health care providers today have concerns about the cardiovascular ...References1. Bril F, Cusi K. Nonalcoholic fatty liver disease: the new complication of type 2 diabetes mellitus. Endocrinol Metab Clin North Am. 2016;45:765-81. [PMID: 27823604] doi:10.1016/j.ecl.2016.06.005 CrossrefMedlineGoogle Scholar2. Einhorn D, Fonseca V. Revisiting the use of pioglitazone in the treatment of type 2 diabetes. Endocr Pract. 2016;22:1343-6. [PMID: 27540881] CrossrefMedlineGoogle Scholar3. Soccio RE, Chen ER, Lazar MA. Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. Cell Metab. 2014;20:573-91. [PMID: 25242225] doi:10.1016/j.cmet.2014.08.005 CrossrefMedlineGoogle Scholar4. Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, et al; IRIS Trial Investigators. Pioglitazone after ischemic stroke or transient ischemic attack. N Engl J Med. 2016;374:1321-31. [PMID: 26886418] doi:10.1056/NEJMoa1506930 CrossrefMedlineGoogle Scholar5. Bril F, Cusi K. Management of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a call to action. Diabetes Care. 2017. doi:10.2337/dc16-1787 CrossrefGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Florida and Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-1774. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus Kenneth Cusi , Beverly Orsak , Fernando Bril , Romina Lomonaco , Joan Hecht , Carolina Ortiz-Lopez , Fermin Tio , Jean Hardies , Celia Darland , Nicolas Musi , Amy Webb , and Paola Portillo-Sanchez Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis James A. Thomas , Rohit Gupta , and Guruprasad P. Aithal Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis Stuart K. Sutton Metrics Cited byGlycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver DiseaseWhat Are the Current Pharmacological Therapies for Nonalcoholic Fatty Liver Disease?Plasma Fibroblast Growth Factor 21 Is Associated With Severity of Nonalcoholic Steatohepatitis in Patients With Obesity and Type 2 DiabetesNutritional and Dietary Interventions for Nonalcoholic Fatty Liver Disease 7 February 2017Volume 166, Issue 3Page: 230KeywordsDisclosureFibrosisHealth care providersLinear regression analysisLiver fibrosisLung and intrathoracic tumorsNonalcoholic steatohepatitisPatientsSafetyWeight gain ePublished: 7 February 2017 Issue Published: 7 February 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...