tbuckley/cabot-search huggingface dataset:
Impact of remote patient monitoring on clinical outcomes: an updated meta-analysis of randomized controlled trials
Authors: Benjamin Noah, Michelle S. Keller, Sasan Mosadeghi, Libby Stein, Sunny Johl, Sean Delshad, Vartan C. Tashjian, Daniel Lew, James T. Kwan, Alma Jusufagic, Brennan M. R. Spiegel
Journal: npj Digital Medicine (2017)

Despite growing interest in remote patient monitoring, limited evidence exists to substantiate claims of its ability to improve outcomes. Our aim was to evaluate randomized controlled trials (RCTs) that assess the effects of using wearable biosensors (e.g. activity trackers) for remote patient monitoring on clinical outcomes. We expanded upon prior reviews by assessing effectiveness across indications and presenting quantitative summary data. We searched for articles from January 2000 to October 2016 in PubMed, reviewed 4,348 titles, selected 777 for abstract review, and 64 for full text review. A total of 27 RCTs from 13 different countries focused on a range of clinical outcomes and were retained for final analysis; of these, we identified 16 high-quality studies. We estimated a difference-in-differences random effects meta-analysis on select outcomes. We weighted the studies by sample size and used 95% confidence intervals (CI) around point estimates. Difference-in-difference point estimation revealed no statistically significant impact of remote patient monitoring on any of six reported clinical outcomes, including body mass index (-0.73; 95% CI: -1.84, 0.38), weight (-1.29; -3.06, 0.48), waist circumference (-2.41; -5.16, 0.34), body fat percentage (0.11; -1.56, 1.34), systolic blood pressure (-2.62; -5.31, 0.06), and diastolic blood pressure (-0.99; -2.73, 0.74). Studies were highly heterogeneous in their design, device type, and outcomes. Interventions based on health behavior models and personalized coaching were most successful. We found substantial gaps in the evidence base that should be considered before implementation of remote patient monitoring in the clinical setting.
Long-Term Treatment with Ibrutinib in Chronic Lymphocytic Leukemia Patients Normalizes CD3+ and CD8+ T Cells and Immune Checkpoints Expression but Gradually Leads to CD4+ T-Cell Depletion
Authors: Marzia Palma, Kia Heimersson, Barbro Näsman-Glaser, Håkan Mellstedt, Anders Österborg
Journal: Blood (2017)
Plasma renin activity, response to aliskiren, and clinical outcomes in patients hospitalized for heart failure: the ASTRONAUT trial
Authors: Muthiah Vaduganathan, Baljash Cheema, Erin Cleveland, Kamya Sankar, Haris Subacius, Gregg C. Fonarow, Scott D. Solomon, Eldrin F. Lewis, Stephen J. Greene, Aldo P. Maggioni, Michael Böhm, Faiez Zannad, Javed Butler, Mihai Gheorghiade
Journal: European Journal of Heart Failure (2017)
European position statement on lung cancer screening
Authors: Matthijs Oudkerk, Anand Devaraj, Rozemarijn Vliegenthart, Thomas Henzler, Helmut Prosch, Claus P Heussel, Gorka Bastarrika, Nicola Sverzellati, Mario Mascalchi, Stefan Delorme, David R Baldwin, Matthew E Callister, Nikolaus Becker, Marjolein A Heuvelmans, Witold Rzyman, Maurizio V Infante, Ugo Pastorino, Jesper H Pedersen, Eugenio Paci, Stephen W Duffy, Harry de Koning, John K Field
Journal: The Lancet Oncology (2017)
A Fair Interpretation
Authors: Anna DeForest
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intestinal organoid culture model is a valuable system to study epithelial barrier function in IBD
Authors: Pan Xu, Heike Becker, Montserrat Elizalde, Ad Masclee, Daisy Jonkers
Journal: Gut (2017)

With great interest, we have read the article by Dotti et al ,1 who analysed the transcriptional signature of epithelial organoid cultures (EpOCs) generated from patients with UC and non-IBD controls. They identified a set of genes that were differentially expressed between UC and control EpOCs, among which several were associated with epithelial secretory and antimicrobial defense. The authors further stated that the organoid culture system could serve as a model to explore the intestinal epithelium of patients with IBD. We hereby provide new support that intestinal organoid culture is also a valuable model to study epithelial barrier function, which has emerged as hallmark for IBD pathogenesis.

Although expression of genes and proteins related to epithelial junctional complex has been investigated in biopsies of patients with IBD, functional analyses of the intestinal barrier remains challenging. To this end, we established an EpOCs library from …
Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorder
Authors: Ye Liu, Xiao-Ying Zhu, Xiao-Jin Zhang, Sheng-Han Kuo, William G. Ondo, Yun-Cheng Wu
Journal: Translational Neurodegeneration (2017)

Rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confirm the clinical features of RBD in Chinese PD patients. One hundred fifty PD patients were enrolled from the Parkinson`s disease and Movement Disorders Center in Department of Neurology, Shanghai General Hospital from January 2013 to August 2014. This study examined PD patients with or without RBD as determined by the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), assessed motor subtype by Unified PD Rating Scale (UPDRS) III at "on" state, and compared the sub-scale scores representing tremor, rigidity, appendicular and axial. Investigators also assessed the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Parkinson's disease Sleep Scale (PDSS). One hundred fourty one PD patients entered the final study. 30 (21.28%) PD patients had probable RBD (pRBD) diagnosed with a RBDSQ score of 6 or above. There were no significant differences for age, including age of PD onset and PD duration, gender, smoking status, alcohol or coffee use, presence of anosmia or freezing, UPDRS III, and H-Y stages between the pRBD+ and pRBD− groups. pRBD+ group had lower MMSE scores, higher PDSS scores, and pRBD+ PD patients had more prominent proportion in anxiety, depression, constipation, hallucination and a greater prevalence of orthostatic hypotension. pRBD+ PD patients exhibited greater changes in non-motor symptoms. However, there was no increase in motor deficits.
Abstract 16693: The Effect of Exercise Training on Coronary Flow Velocity Reserve in Chronic Heart Failure Patients
Authors: Martin Snoer, Tea Monk-Hansen, Rasmus H Olsen, Flemming Dela, Eva Prescott
Journal: Circulation (2016)

Introduction: Exercise training improves physical function in heart failure (HF) patients, but the exact mechanisms are not fully understood. Coronary flow velocity reserve (CFVR) is a measure of m...
Inflammation-dependent regulation of epithelial-mesenchymal transition in non-small cell lung cancer: the role of interleukin-1β
Authors: Eileen Heinrich, Miriam Dohadwala, Burt Charuworn, Steven Dubinett
Journal: Cancer Research (2008)

5366   Pulmonary disorders such as emphysema and pulmonary fibrosis are characterized by abnormalities in inflammatory pathways as well as a heightened risk of cancer development. The inflammatory cytokines, growth factors and mediators released in the pulmonary microenvironment in these conditions include, tumor necrosis factor-α (TNF-α), PGE2, transforming growth factor-β (TGF-β) and interleukin 1-β (IL-1β). Here we have studied the link between inflammation and epithelial mesenchymal transition (EMT), a process whereby cells undergo changes from a highly polarized epithelial phenotype to a mesenchymal, migratory phenotype. These changes lead to a more invasive phenotype and poor patient prognosis. Our findings indicate that IL-1β down regulates E-cadherin in non-small cell lung cancer (NSCLC) cells. IL-1β treatment also leads to the up regulation of the mesenchymal markers vimentin and N-cadherin. This IL-1β mediated regulation of EMT markers is MEK/ERK dependent. In a 3-dimensional cell culture system NSCLC cells form distinct spheroid structures. This spheroid formation is disrupted in the presence of IL-1β, with cells acquiring a mesenchymal phenotype.  Down regulation of E-cadherin, a hallmark of EMT, can result from up regulation of transcriptional repressors that bind the E-cadherin promoter. We show that treatment of NSCLC cell lines with IL-1β leads to an increase in the mRNA of the E-cadherin transcriptional repressor Slug and a concurrent decrease in E-cadherin expression. As indicated in chromatin immunoprecipitation assays, we find that Slug binds to the E-cadherin promoter, causing transcriptional repression. Thus, IL-1β, a cytokine abundantly present in the lung cancer microenvironment, has the capacity to regulate Slug.  We conclude that IL-1β contributes to EMT in NSCLC. Thus our findings suggest a role for the E-cadherin transcriptional repressor Slug in inflammation-induced promotion of EMT in NSCLC.
A major blow to primate neonatal imitation and mirror neuron theory
Authors: W. Tecumseh Fitch
Journal: Behavioral and Brain Sciences (2017)

Keven & Akins' (K&A's) compelling new hypothesis explaining the developmental and neural basis of neonatal tongue protrusion has important implications for current understanding of primate imitation and the explanatory value of mirror neurons. If correct, this hypothesis eliminates a major source of evidence for neonatal imitation. I explore the implications this has for mirror neuron research and the arguments building upon them.
Evaluación de la eficacia del tratamiento endoscópico de complicaciones postquirúrgicas gastrointestinales
Authors: H Martinez Lozano, C Martinez Flores, J García Lledó, Ó Nogales Rincón, B Merino Rodríguez, L Pérez Carazo, M López Ibáñez, R Bañares Cañizares
Journal: Endoscopy (2017)

Las fugas, fístulas y estenosis anastomóticas son complicaciones postquirúrgicas. Asocian elevada morbimortalidad requiriendo desde medidas mínimamente invasivas hasta cirugías de resección.
Triple Vectors Expand AAV Transfer Capacity in the Retina
Authors: Andrea Maddalena, Patrizia Tornabene, Paola Tiberi, Renato Minopoli, Anna Manfredi, Margherita Mutarelli, Settimio Rossi, Francesca Simonelli, Jurgen K. Naggert, Davide Cacchiarelli, Alberto Auricchio
Journal: Molecular Therapy (2017)

Retinal gene transfer with adeno-associated viral (AAV) vectors holds great promise for the treatment of inherited retinal degenerations (IRDs). One limit of AAV is its transfer capacity of about 5 kb, which can be expanded to about 9 kb, using dual AAV vectors. This strategy would still not suffice for treatment of IRDs such as Usher syndrome type 1D or Alström syndrome type I (ALMS) due to mutations in CDH23 or ALMS1, respectively. To overcome this limitation, we generated triple AAV vectors, with a maximal transfer capacity of about 14 kb. Transcriptomic analysis following triple AAV transduction showed the expected full-length products along a number of aberrant transcripts. However, only the full-length transcripts are efficiently translated in vivo. We additionally showed that approximately 4% of mouse photoreceptors are transduced by triple AAV vectors and showed correct localization of recombinant ALMS1. The low-photoreceptor transduction levels might justify the modest and transient improvement we observe in the retina of a mouse model of ALMS. However, the levels of transduction mediated by triple AAV vectors in pig retina reached 40% of those observed with single vectors, and this bodes well for further improving the efficiency of triple AAV vectors in the retina.
Mucosal Healing and Long-term Outcomes of Patients With Inflammatory Bowel Diseases Receiving Clinic-Based vs Trough Concentration-Based Dosing of Infliximab
Authors: Lieven Pouillon, Marc Ferrante, Gert Van Assche, Paul Rutgeerts, Maja Noman, João Sabino, Niels Vande Casteele, Ann Gils, Séverine Vermeire
Journal: Clinical Gastroenterology and Hepatology (2017)
PTU-041 Single centre study evaluating a hybrid network solution for an upper gi bleed rota
Authors: KK Yong, R Peters, J Marshall, A Ellis
Journal: Gut (2017)

Introduction  The Horton General Hospital (HGH) is a small DGH located 30 miles away from a tertiary endoscopy centre, John Radcliffe Hospital (JRH). Both hospitals are part of Oxford University Hospitals NHS Foundation Trust  In October 2015, the endoscopy unit at the HGH closed for 1 year for a refurbishment to maintain JAG compliance. During that time it was possible to provide urgent ‘next day’ endoscopy for in-patients but not a full 24/7 emergency service. A model of care was devised whereby any patient requiring emergency out-of-hours endoscopy was stabilised and transferred to JRH.  This is an observational study to determine the safety of emergency endoscopy service provision using a ‘hub and spoke’ model between district general and tertiary centre within a single trust.  Method  Data was collected prospectively using the Endobase reporting system and electronic patient discharge letter. Patient demographics, reason for referral, endoscopic findings, endoscopic interventions and patient survival were extracted electronically. The endpoints were 24 hour, 7 days, 28 days survival of patients transferred to the JRH prior to receiving endoscopy at the HGH and those transferred to JRH for further endoscopic interventions.  Results  During the 1 year observational period, 184 referrals for inpatient urgent or emergency endoscopy were received. The majority of referrals (94%) were managed at HGH on a ‘next morning basis.’ A total of 11 patients (6%) required transfer to the JRH following initial resuscitation by on-call medical teams (Table 1). Only 4 of these 11 transferred patients required endoscopic treatment to achieve haemostasis. Standard dual therapy techniques were used including adrenaline injection, vessel clipping and heater probe. There were no recorded deaths at 24 hours, 7 days and 28 days for any patient who received resuscitation at the HGH prior to transfer for endoscopy at the JRH.  4 patients (2%) received an initial endoscopy at HGH but later required transfer to JRH for on-going management (Table 2).  There were 3 deaths (1.6%) during the study; one 87 year old from an unrelated myocardial infarction following an OGD for a M-W tear, one 72 year old from a perforated duodenal ulcer identified at endoscopy and one 89 year old from an iatrogenic oesophageal perforation managed conservatively due to age and co-morbidities.  Conclusion  This one year observational study demonstrates that a safe and effective out of hours 24/7 endoscopy service can be provided using a ‘hub and spoke model’ of care between district general and tertiary referral centre. With increasing financial and service pressures on emergency services throughout the NHS, we suggest that this model could potentially be adopted more widely to support smaller centres that are not able to provide a full 24/7 endoscopy service.  Disclosure of Interest  None Declared
An autofluorescence-based method for the isolation of highly purified ventricular cardiomyocytes
Authors: Veronica Larcher, Paolo Kunderfranco, Marco Vacchiano, Pierluigi Carullo, Marco Erreni, Irene Salamon, Federico Simone Colombo, Enrico Lugli, Marta Mazzola, Achille Anselmo, Gianluigi Condorelli
Journal: Cardiovascular Research (2017)

The aim of our study was to set up a simple and reliable isolation method of living ventricular cardiomyocytes (vCMs) for molecular and biological studies.A standard technique for the retrograde perfusion of an enzymatic solution was used to isolate cardiac cells from adult mouse heart. Fluorescence-activated cell sorting (FACS) on adult murine cardiac ventricle cells was performed, comparing the intrinsic autofluorescence in the FITC channel and the forward scatter (FSC) parameter in order to isolate highly fluorescent cells. The expression of cell-specific mRNAs was assessed with real-time PCR in cells sorted on the basis of their FITC and FSC characteristics. We identified two distinct subpopulations of cells harvested after retrograde perfusion of wild-type heart: FITChigh/FSCdim and FITCdim/FSChigh. Immunophenotyping and mRNA analysis (qPCR and RNA sequencing) revealed that only FITChigh/FSCdim cells were highly enriched in CM markers. Genes with high expression in endothelial cells and fibroblasts were enriched in the FITCdim/FSChigh subpopulation. With the use of tdTomatofl/fl-α-myosin heavy chain MerCreMer+/-mouse heart, we found that tdTomato-positive vCMs were present in the FITChigh/FSCdim region but were only rare in the FITCdim/FSChigh fraction.We have developed a simple and reliable method for the isolation of highly purified vCMs from the adult murine myocardium, avoiding fixation and permeabilization steps. These isolated vCMs can be used in particular for detailed molecular studies, avoiding contamination with other myocardial cell types.
RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait
Authors: Stephanie C. Koch, Marta Garcia Del Barrio, Antoine Dalet, Graziana Gatto, Thomas Günther, Jingming Zhang, Barbara Seidler, Dieter Saur, Roland Schüle, Martyn Goulding
Journal: Neuron (2017)
Generation of Clonal Antigen Specific CD8αβ+ Cytotoxic T Lymphocytes from Renewable Pluripotent Stem Cells for Off-the-Shelf T Cell Therapeutics
Authors: Sjoukje Van Der Stegen, Raedun Clarke, Jorge Mansilla Soto, Edwin Ortiz, Chia-Wei Chang, Jeff Sasaki, Tom Lee, Weijie Lan, Daniel Shoemaker, Isabelle Riviere, Bahram Valamehr, Michel Sadelain
Journal: Blood (2017)
Real World Treatment Outcomes and Cost Among Newly-Diagnosed Multiple Myeloma Patients Treated with Bortezomib and Dexamethasone in Combination with Cyclophosphamide or Lenalidomide
Authors: Lin Xie, Kejal Parikh, Safiya Abouzaid, Shivani Pandya, Onur Baser, Manali I. Patel
Journal: Blood (2016)
Accelerated subcutaneous immunotherapy in pediatric population – Systematic review
Authors: R.A. Gomes dos Reis Pimentel, G. Oliveira, C.S. Ferreira Chaves Loureiro e Lemos
Journal: Pulmonology (2017)

Accelerated subcutaneous immunotherapy (SCIT) schedules represent an alternative to conventional SCIT, providing immunotherapy benefits in a shorter period of time. The objectives of this systematic review were to assess clinical and immunological efficacy as well as safety of accelerated SCIT build-up schedules for the treatment of respiratory allergy in pediatric patients.
Age is a predictor of a small decrease in lung function in children with sickle cell anemia
Authors: Shaina M. Willen, Robyn Cohen, Mark Rodeghier, Fenella Kirkham, Susan S. Redline, Carol Rosen, Jane Kirkby, Michael R. DeBaun
Journal: American Journal of Hematology (2017)

Abstract The longitudinal pattern of lung function in children with sickle cell anemia (SCA) has shown a decrease in FEV 1 % predicted, a risk factor for death in adults with SCA, but predictors for this decline are poorly characterized. In a prospective longitudinal multi‐center cohort of children with SCA, we tested the hypotheses that: (1) FEV 1 % predicted declines over time; and (2) SCA‐specific characteristics and therapy predict this decline. At three clinical centers, children with SCA (HbSS or HbSβ 0 thalassemia), unselected for respiratory disease, were enrolled in the Sleep and Asthma Cohort (SAC) study. Study‐certified pulmonary function technicians performed spirometry and lung volumes. Each assessment was reviewed centrally. Predicted values were determined for TLC, FEV 1 , FVC, and FEV 1 /FVC ratio. A total of 197 participants, mean age 11.0 years at first testing (range 4‐19.3 years), had a minimum of three spirometry measurements, over an average of 4.4 years (range 1.1‐6.5 years) from baseline to endpoint. In a multivariable model, FEV 1 % predicted declines by 0.3% for every additional year of age (95% CI −0.56 to −0.05, P = .020). Sex, asthma history, hemoglobin, reticulocyte count, white blood cell count, incidence rate of severe acute pain and acute chest syndrome episodes, and hydroxyurea therapy were not associated with a decline in FEV 1 % predicted. In a large, rigorously evaluated, prospective cohort of an unselected group of children with SCA, FEV 1 % predicted declines minimally over an average of 4 years, and none of the examined disease features predict the decline.
Zoledronic Acid Dosing in Patients With Metastatic Breast Cancer
Authors: Charles L. Shapiro, Andrew L. Himelstein
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
The immune modulation role of low dosage of cyclosporin-A (ldCSA) in the antitumor response of CD8+ T lymphocytes (CD8+Tcells) and the implication of neuropilin-1 (Nrp1)
Authors: C. Flores, O. Hermine, T. Maciel, R. Rignault, J. Rossignol, Y. Lepelletier
Journal: Annals of Oncology (2017)