tbuckley/cabot-search huggingface dataset:
EURAMOS-1 study: Recruitment, characteristics, and initial treatment of more than 2,000 patients (pts) with high-grade osteosarcoma.
Authors: Jeremy Whelan, Jane Hook, Stefan S. Bielack, Neyssa Marina, Sigbjorn Smeland, Gordana Jovic, Mark D. Krailo, Thomas Kühne, Mikael Eriksson, Trude Butterfass-Bahloul, Lisa A. Teot, Leo Kager, Hans Gelderblom, Kirsten Sundby Hall, Pancras C. W. Hogendoorn, Matthew Robert Sydes, Mark L. Bernstein
Journal: Journal of Clinical Oncology (2012)

10081 Background: EURAMOS is a transAtlantic collaboration formed to improve survival in osteosarcoma by conducting RCTs in a clinically relevant timeframe. EURAMOS-1, the largest study conducted in this rare cancer, has completed accrual. It includes two randomized comparisons investigating treatment optimization on the basis of histological response to neoadjuvant chemotherapy. Methods: Pts ≤40yrs with resectable, high grade extremity or axial osteosarcoma were eligible for registration. All were planned for 2 cycles of neoadjuvant methotrexate, doxorubicin, cisplatin (MAP) then surgical resection of the primary tumour. Pts with complete macroscopic resection and no disease progression were eligible for randomization: [i] “good responders”, &lt;10% viable tumor, MAP +/- 18m maintenance pegylated interferon; [ii] “poor responders”, ≥10% viable tumor, MAP vs MAPIE (MAP + ifosfamide, etoposide). Target sample size was ~1,260 pts randomized requiring ~2000 pts registered estimating a non-randomization rate of 30-35%. Results: From Apr 2005 to Dec 2011, 2,260 pts were registered and 1,332 randomized from 17 countries, 320 sites: median age 14yrs (IQR 11-17); 59% male; 50% femoral site; 23% definite/possible metastases; 92% conventional osteosarcoma (diagnostic biopsy). At Sep 2011 planned IDMC review, neoadjuvant treatment data were known for 2024 pts; 1926 (95%) completed 2 cycles pre-operative MAP with 3 treatment related deaths. 59% pts were randomized; non-consent was the most frequent reason for non-randomization. Relative to expected age-specific incidence (UK NCIN 1979-2007) there was apparent under recruiting of older pts: females ≥15yrs and all pts &gt;19yrs, with greater under recruitment of females than males &lt;35yrs. Pts 20-29yrs were less likely to be randomized than those aged 5-19 and ≥30 yrs, 52% vs 57-62%. Conclusions: EURAMOS-1 demonstrates that large RCTs are feasible in rare cancers with inter-continental collaboration and is a model for future trials. Neoadjuvant MAP was safe in a geographically diverse cohort. Improving clinical trial access and randomization rates for young people is still required. Multiple funders detailed at bit.ly/ymUR9w.
Combining computer modelling and cardiac imaging to understand right ventricular pump function
Authors: John Walmsley, Wouter van Everdingen, Maarten J. Cramer, Frits W. Prinzen, Tammo Delhaas, Joost Lumens
Journal: Cardiovascular Research (2017)

Right ventricular (RV) dysfunction is a strong predictor of outcome in heart failure and is a key determinant of exercise capacity. Despite these crucial findings, the RV remains understudied in the clinical, experimental, and computer modelling literature. This review outlines how recent advances in using computer modelling and cardiac imaging synergistically help to understand RV function in health and disease. We begin by highlighting the complexity of interactions that make modelling the RV both challenging and necessary, and then summarize the multiscale modelling approaches used to date to simulate RV pump function in the context of these interactions. We go on to demonstrate how these modelling approaches in combination with cardiac imaging have improved understanding of RV pump function in pulmonary arterial hypertension, arrhythmogenic right ventricular cardiomyopathy, dyssynchronous heart failure and cardiac resynchronization therapy, hypoplastic left heart syndrome, and repaired tetralogy of Fallot. We conclude with a perspective on key issues to be addressed by computational models of the RV in the near future.
二重活性リゾホスファチジン酸受容体汎アンタゴニスト/自動タキシン抑制薬は,in vitroで乳癌細胞遊走を低下させて,in vivoで腫瘍退縮を生じる
Authors: Zhang Honglu, XU Xiaoyu, Gajewiak Joanna, Tsukahara Ryoko, Fujiwara Yuko, Liu Jianxiong, I Fells James, Perygin Donna, L Parrill Abby, Tigyi Gabor, D Prestwich Glenn
Journal: Cancer Research (2009)
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation
Authors: Pingzhao Zhang, Dejie Wang, Yu Zhao, Shancheng Ren, Kun Gao, Zhenqing Ye, Shangqian Wang, Chun-Wu Pan, Yasheng Zhu, Yuqian Yan, Yinhui Yang, Di Wu, Yundong He, Jun Zhang, Daru Lu, Xiuping Liu, Long Yu, Shimin Zhao, Yao Li, Dong Lin, Yuzhuo Wang, Liguo Wang, Yu Chen, Yinghao Sun, Chenji Wang, Haojie Huang
Journal: Nature Medicine (2017)
尿中8‐ヒドロキシ‐2’‐デオキシグアノシン濃度は心不全の重症度と関連して上昇する
Authors: Nagayoshi Y, Hokamaki J, Soejima H, Miyamoto S, Kojima S, Maruyoshi H, Sakamoto T, Yoshimura M, Tsujita K
Journal: Circulation (2003)
Nonvoluntary Psychiatric Treatment Is Distinct From Involuntary Psychiatric Treatment
Authors: Dominic A. Sisti
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Negative results are needed to show the specific value of a cultural explanation for <i>g</i>
Authors: Ruben C. Arslan, Christoph J. von Borell, Julia Ostner, Lars Penke
Journal: Behavioral and Brain Sciences (2017)

Abstract Burkart et al. suggest that social learning can explain the cognitive positive manifold for social animals, including humans. We caution that simpler explanations of positive trait intercorrelations exist, such as genetic load. To test the suggested explanation's specificity, we also need to examine non-social species and traits, such as health, that are distal to cognitive abilities.
<i>G</i>and<i>g</i>: Two markers of a general cognitive ability, or none?
Authors: Charles Locurto
Journal: Behavioral and Brain Sciences (2017)

Abstract The search for general processes that underlie intelligence in nonhumans has followed two strategies: one that concerns observing differences between nonhuman species ( G ), the second that concerns observing individual differences within a nonhuman species ( g ). This commentary takes issue with both attempts to mark a general factor: Differential responding to contextual variables compromises the search for G , and the lack of predictive validity compromises g .
Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly
Authors: Martin Jacko, Sebastien M. Weyn-Vanhentenryck, John W. Smerdon, Rui Yan, Huijuan Feng, Damian J. Williams, Joy Pai, Ke Xu, Hynek Wichterle, Chaolin Zhang
Journal: Neuron (2018)
Adding molecular data to prognostic models can improve predictive power in treated patients with myelodysplastic syndromes
Authors: A Nazha, K Al-Issa, B K Hamilton, T Radivoyevitch, A T Gerds, S Mukherjee, V Adema, A Zarzour, N Abuhadra, B J Patel, C M Hirsch, A Advani, B Przychodzen, H E Carraway, J P Maciejewski, M A Sekeres
Journal: Leukemia (2017)
ラクダ類単一ドメイン抗体:細胞外と細胞内脳標的のin vivo造影に対する多用途ツール
Authors: Li Tengfei, Vandesquille Matthias, Koukouli Fani, Dudeffant Clemence, Youssef Ihsen, Lenormand Pascal, Ganneau Christelle, Maskos Uwe, Czech Christian, Grueninger Fiona, Duyckaerts Charles, Dhenain Marc, Bay Sylvie, Delatour Benoit, Lafaye Pierre
Journal: Journal of Controlled Release (2016)
NOX5 and p22phox are 2 novel regulators of human monocytic differentiation into dendritic cells
Authors: Viviana Marzaioli, Margarita Hurtado-Nedelec, Coralie Pintard, Asma Tlili, Jean-Claude Marie, Renato C. Monteiro, Marie-Anne Gougerot-Pocidalo, Pham My-Chan Dang, Jamel El-Benna
Journal: Blood (2017)
Transcatheter Mitral Valve Replacement for Degenerated Bioprosthetic Valves and Failed Annuloplasty Rings
Authors: Sung-Han Yoon, Brian K. Whisenant, Sabine Bleiziffer, Victoria Delgado, Niklas Schofer, Lena Eschenbach, Buntaro Fujita, Rahul Sharma, Marco Ancona, Ermela Yzeiraj, Stefano Cannata, Colin Barker, James E. Davies, Antonio H. Frangieh, Florian Deuschl, Tomaz Podlesnikar, Masahiko Asami, Abhijeet Dhoble, Anthony Chyou, Jean-Bernard Masson, Harindra C. Wijeysundera, Daniel J. Blackman, Rajiv Rampat, Maurizio Taramasso, Enrique Gutierrez-Ibanes, Tarun Chakravarty, Guiherme F. Attizzani, Tsuyoshi Kaneko, S. Chiu Wong, Horst Sievert, Fabian Nietlispach, David Hildick-Smith, Luis Nombela-Franco, Lenard Conradi, Christian Hengstenberg, Michael J. Reardon, Albert Markus Kasel, Simon Redwood, Antonio Colombo, Saibal Kar, Francesco Maisano, Stephan Windecker, Thomas Pilgrim, Stephan M. Ensminger, Bernard D. Prendergast, Joachim Schofer, Ulrich Schaefer, Jeroen J. Bax, Azeem Latib, Raj R. Makkar
Journal: Journal of the American College of Cardiology (2017)
Effect of Access to an Electronic Medical Resource on Performance Characteristics of a Certification Examination
Authors: Rebecca S. Lipner, Bradley G. Brossman, Kelli M. Samonte, Steven J. Durning
Journal: Annals of Internal Medicine (2017)

Electronic resources are increasingly used in medical practice. Their use during high-stakes certification examinations has been advocated by many experts, but whether doing so would affect the capacity to differentiate between high and low abilities is unknown.To determine the effect of electronic resources on examination performance characteristics.Randomized controlled trial.Medical certification program.825 physicians initially certified by the American Board of Internal Medicine (ABIM) who passed the Internal Medicine Certification examination or sat for the Internal Medicine Maintenance of Certification (IM-MOC) examination in 2012 to 2015.Participants were randomly assigned to 1 of 4 conditions: closed book using typical or additional time, or open book (that is, UpToDate [Wolters Kluwer]) using typical or additional time. All participants took the same modified version of the IM-MOC examination.Primary outcomes included item difficulty (how easy or difficult the question was), item discrimination (how well the question differentiated between high and low abilities), and average question response time. Secondary outcomes included examination dimensionality (that is, the number of factors measured) and test-taking strategy. Item response theory was used to calculate question characteristics. Analysis of variance compared differences among conditions.Closed-book conditions took significantly less time than open-book conditions (mean, 79.2 seconds [95% CI, 78.5 to 79.9 seconds] vs. 110.3 seconds [CI, 109.2 to 111.4 seconds] per question). Mean discrimination was statistically significantly higher for open-book conditions (0.34 [CI, 0.32 to 0.35] vs. 0.39 [CI, 0.37 to 0.41] per question). A strong single dimension showed that the examination measured the same factor with or without the resource.Only 1 electronic resource was evaluated.Inclusion of an electronic resource with time constraints did not adversely affect test performance and did not change the specific skill or factor targeted by the examination. Further study on the effect of resource inclusion on other examinations is warranted.ABIM Foundation.
Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)
Authors: Jacob Schachter, Antoni Ribas, Georgina V Long, Ana Arance, Jean-Jacques Grob, Laurent Mortier, Adil Daud, Matteo S Carlino, Catriona McNeil, Michal Lotem, James Larkin, Paul Lorigan, Bart Neyns, Christian Blank, Teresa M Petrella, Omid Hamid, Honghong Zhou, Scot Ebbinghaus, Nageatte Ibrahim, Caroline Robert
Journal: The Lancet (2017)
Screening for Colorectal Cancer
Authors: Tazia K. Stagg
Journal: Annals of Internal Medicine (2012)

Letters7 August 2012Screening for Colorectal CancerTazia K. Stagg, MD, MPHTazia K. Stagg, MD, MPHFrom James A. Haley Veterans Hospital, Tampa, FL 33612.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-3-201208070-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Qaseem and colleagues' (1) recommendation on when to stop CRC screening is problematic. In seeking clarification, I was unable to trace the origin of Guidance Statement 4. Did it arise from the “rigorous review of the available guidelines” or from new evidence not referenced? According to the summaries in the article, only one of the guidelines reviewed—that of the USPSTF—provided guidance on when to stop screening. However, judging from the fact that Qaseem and colleagues used different words to express Guidance Statement 4 (because I don't really know how to interpret it), it seems to depart from ...Reference1. Qaseem A, Denberg TD, Hopkins RH, Humphrey LL, Levine J, Sweet DE, et al; Clinical Guidelines Committee of the American College of Physicians. Screening for colorectal cancer: a guidance statement from the American College of Physicians. Ann Intern Med. 2012;156:378-86. [PMID: 22393133] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From James A. Haley Veterans Hospital, Tampa, FL 33612.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Colorectal Cancer: A Guidance Statement From the American College of Physicians Amir Qaseem , Thomas D. Denberg , Robert H. Hopkins Jr. , Linda L. Humphrey , Joel Levine , Donna E. Sweet , Paul Shekelle , and Screening for Colorectal Cancer Thomas D. Denberg , Linda L. Humphrey , Paul Shekelle , and Amir Qaseem Screening for Colorectal Cancer Ayokunle T. Abegunde Screening for Colorectal Cancer David L. Keller Metrics 7 August 2012Volume 157, Issue 3Page: 218KeywordsCancer screeningColorectal cancerConflicts of interestLife expectancyPublic policy ePublished: 7 August 2012 Issue Published: 7 August 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis
Authors: Yan Yang, Lili Ding, Qun Hu, Jia Xia, Junjie Sun, Xudong Wang, Hua Xiong, Deepak Gurbani, Lianbo Li, Yan Liu, Aiguo Liu
Journal: Molecular Cancer (2017)

Aberrant expression of microRNAs in different human cancer types has been widely reported. MiR-218 acts as a tumor suppressor in diverse human cancer types impacting regulation of multiple genes in oncogenic pathways. Here, we evaluated the expression and function of miR-218 in human lung cancer and ALDH positive lung cancer cells to understand the potential mechanisms responsible for disease pathology. Also, the association between its host genes and the target genes could be useful towards the better understanding of prognosis in clinical settings. Publicly-available data from The Cancer Genome Atlas (TCGA) was mined to compare the levels of miR-218 and its host gene SLIT2/3 between lung cancer tissues and normal lung tissues. Transfection of miR-218 to investigate its function in lung cancer cells was done and in vivo effects were determined using miR-218 expressing lentiviruses. Aldefluor assay and Flow cytometry was used to quantify and enrich ALDH positive lung cancer cells. Levels of miR-218, IL-6R, JAK3 and phosphorylated STAT3 were compared in ALDH1A1 positive and ALDH1A1 negative cells. Overexpression of miR-218 in ALDH positive cells was carried to test the survival by tumorsphere culture. Finally, utilizing TCGA data we studied the association of target genes of miR-218 with the prognosis of lung cancer. We observed that the expression of miR-218 was significantly down-regulated in lung cancer tissues compared to normal lung tissues. Overexpression of miR-218 decreased cell proliferation, invasion, colony formation, and tumor sphere formation in vitro and repressed tumor growth in vivo. We further found that miR-218 negatively regulated IL-6 receptor and JAK3 gene expression by directly targeting the 3′-UTR of their mRNAs. In addition, the levels of both miR-218 host genes and the components of IL-6/STAT3 pathway correlated with prognosis of lung cancer patients. MiR-218 acts as a tumor suppressor in lung cancer via IL-6/STAT3 signaling pathway regulation.
ポリアクリルアミドおよび組換え基底膜の半相互貫入ネットワークはソフト,配位子に富む微小環境における多能性細胞培養を可能にする【Powered by NICT】
Authors: J Price Andrew, Y Huang Eva, Sebastiano Vittorio, R Dunn Alexander
Journal: Biomaterials (2017)
Erratum to “Erratum to “The SCARE guidelines: Consensus-based surgical case report guidelines” [Int. J. Surg. 34 (2016) 180–186]” [Int. J. Surg. 36 (2016) 396]
Authors: Riaz A. Agha, Alexander J. Fowler, Alexandra Saeta, Ishani Barai, Shivanchan Rajmohan, Dennis P. Orgill, Raafat Afifi, Raha Al-Ahmadi, Joerg Albrecht, Abdulrahman Alsawadi, Jeffrey Aronson, M. Hammad Ather, Mohammad Bashashati, Somprakas Basu, Patrick Bradley, Mushtaq Chalkoo, Ben Challacombe, Trent Cross, Laura Derbyshire, Naheed Farooq, Jerome Hoffman, Huseyin Kadioglu, Veeru Kasivisvanathan, Boris Kirshtein, Roberto Klappenbach, Daniel Laskin, Diana Miguel, James Milburn, Seyed Reza Mousavi, Oliver Muensterer, James Ngu, Iain Nixon, Ashraf Noureldin, Benjamin Perakath, Nicholas Raison, Kandiah Raveendran, Timothy Sullivan, Achilleas Thoma, Mangesh A. Thorat, Michele Valmasoni, Samuele Massarut, Anil D'cruz, Baskaran Vasudevan, Salvatore Giordano, Gaurav Roy, Donagh Healy, David Machado-Aranda, Bryan Carroll, David Rosin
Journal: International Journal of Surgery (2017)
Airway calibre variation is a major determinant of exhaled nitric oxide's ability to capture asthma control
Authors: Alain Michils, Amaryllis Haccuria, Sebastien Michiels, Alain Van Muylem
Journal: European Respiratory Journal (2017)

Changes in airway calibre have the potential to modify exhaled nitric oxide fraction ( F ENO ) values and could hamper how F ENO captures changes in asthma control. Here, our objective was to assess whether forced expiratory volume in 1 s (FEV 1 ) variations alter the ability of F ENO to reflect asthma control. F ENO , asthma control (Asthma Control Questionnaire (ACQ)) and FEV 1 were measured at least two times in 527 patients during 1819 pairs of visits. Determinants of F ENO –ACQ discordance probability were evaluated through a logistic regression analysis. The effectiveness of F ENO at capturing either asthma control worsening or improvement between two visits was then assessed by undertaking a stratified receiver operating characteristic curves analysis. When FEV 1 and F ENO change in the same direction, the odds of F ENO –ACQ being discordant are multiplied by 3 (p&lt;0.001). The area under the curve values were 0.765 (95% CI 0.713–0.805) (improvement; p&lt;0.001) and 0.769 (95% 0.706–0.810) (worsening; p&lt;0.001) or 0.590 (95% 0.531–0.653) (improvement; p=0.001) and 0.498 (95% 0.416–0.567) (worsening; p=0.482) when FEV 1 and F ENO changed in the opposite or same direction, respectively. The manner in which F ENO and FEV 1 vary concomitantly when asthma control changes determines the ability of F ENO to capture this change: parallel or opposite changes in FEV 1 and F ENO either decrease or increase this ability to capture asthma control changes.
加齢心臓と骨格筋の生体エネルギー論:最新の概念と論争【Powered by NICT】
Authors: Tepp Kersti, Timohhina Natalja, Puurand Marju, Klepinin Aleksandr, Chekulayev Vladimir, Shevchuk Igor, Kaambre Tuuli
Journal: Ageing Research Reviews (2016)
Antibodies against collagen type II are not a general marker of acute arthritis onset
Authors: Vivek Anand Manivel, Diane van der Woude, Rene Toes, Andrew Filer, Karim Raza, Johan Rönnelid
Journal: Annals of the Rheumatic Diseases (2017)

The fibrillar protein collagen type II (CII) is essentially confined to hyaline cartilage in diarthrodial joints. Antibodies against CII (anti-CII) were previously described in 3%–27% of rheumatoid arthritis (RA) patients, and Kim et al described anti-CII to be associated with elevated levels of C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in a heterogeneous group of RA patients with 2–432 months of disease duration.1 Contrary to anticitrullinated protein antibodies, anti-CII are not detected before RA onset.2 We have shown that anti-CII levels are highest at the time of RA diagnosis and thereafter decline, and that elevated anti-CII levels at diagnosis associate with elevated CRP, ESR, swollen joint count, disease activity score and radiological destruction at the time of diagnosis but not later, thus representing an acute onset RA phenotype.3–5 It is plausible that production of pro-inflammatory cytokines by macrophages …
Diagnosis of acute groin injuries in athletes
Authors: Andreas Serner
Journal: British Journal of Sports Medicine (2017)

I investigated injury situations and methods for clinical and imaging examinations in the diagnosis of acute groin injuries in athletes.

Acute groin injuries are common in team sports, yet research was close to non-existent. Anatomical studies have provided greater insight into the complexity of the musculotendinous structures in the groin, but the relationship with acute injury was unexplored. Improving knowledge related to the diagnosis would improve both the prevention and management.

Elite and subelite athletes with acute groin pain presenting at Aspetar Sports Medicine Hospital (Doha, Qatar) within 1 week of injury were included. We standardised registration of injury situations, clinical diagnoses and ultrasound and MRI findings performed by sports medicine physicians and radiologists in daily practice (study 1).1 I also performed an extensive standardised clinical examination prior …
Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob
Authors: Lisa K. Denzin, Aly A. Khan, Francesca Virdis, Jessica Wilks, Melissa Kane, Helen A. Beilinson, Stanislav Dikiy, Laure K. Case, Derry Roopenian, Michele Witkowski, Alexander V. Chervonsky, Tatyana V. Golovkina
Journal: Immunity (2017)