tbuckley/cabot-search huggingface dataset:
The economic impact of using single-operator cholangioscopy for the treatment of difficult bile duct stones and diagnosis of indeterminate bile duct strictures
Authors: Pierre Deprez, Rodrigo Garces Duran, Tom Moreels, Gianluca Furneri, Federica Demma, Len Verbeke, Schalk Van der Merwe, Wim Laleman
Journal: Endoscopy (2017)

Abstract Background and study aim Conventional endoscopic retrograde cholangiopancreatography (ERCP) combines endoscopy and radiography to diagnose and treat pathological conditions of the bile duct. The aim of the present analysis was to evaluate the clinical and economic impact of the use of single-operator intraductal cholangioscopy (IDC), which allows for direct visualization of the bile duct, as an alternative to ERCP for the treatment of difficult bile duct stones and the diagnosis of bile duct strictures. Patients and methods The clinical and economic consequences of single-operator IDC use were evaluated using two decision-tree models, one for management of difficult-to-remove stones and one for stricture diagnosis. A hospital perspective was adopted. Data to populate the models were derived from two Belgian hospitals that specialize in endoscopic procedures of the bile duct. Overall, the examined population consisted of 62 patients with difficult stones and 49 patients with indeterminate strictures. Results In the model for difficult stone management, the use of IDC determined a decrease in the number of procedures (– 27 % relative reduction) and costs (– €73 000; – 11 % relative reduction) when compared with ERCP. In the model for stricture diagnosis, the use of IDC determined a decrease in the number of procedures (– 31 % relative reduction) and costs (– €13 000; – 5 % relative variation) when compared with ERCP. Conclusions The single-operator IDC system performed better than ERCP for the treatment of difficult bile duct stones and the diagnosis of bile duct strictures, and reduced the overall expenditure in hospitals in Belgium.
Green tea metabolite (-)epigallocatechin-3-gallate inhibits growth and polyamines in urothelial carcinoma of the bladder
Authors: Jason Gee, Corrie Burmeister, Kiley Djupstrom
Journal: Cancer Research (2007)

4214  INTRO & OBJECTIVE: Epidemiologic studies suggest regular consumers of green tea have a lower risk of bladder cancer. The chemopreventive effects of green tea against tumorigenesis have been attributed to its polyphenolic constituents, especially (-)epigallocatechin-3-gallate (EGCG), although its mechanism of action remains unclear. Here we study the effects of EGCG on growth and polyamine synthesis in human urothelial carcinoma of the bladder.  METHODS: Urothelial carcinoma cells representing low grade (RT4, TCC 96-1) and high grade (UM-UC-3) bladder cancer were grown in the presence of increasing concentrations of EGCG (0-50uM). Cell growth was quantitated over 7 days using crystal violet elution. Polyamine levels (putrescine, spermidine and spermine) were determined by HPLC analysis in the same three cell lines following treatment with 0-50uM EGCG x 24 hours.  RESULTS: EGCG inhibited the growth of all three cell lines in a dose-dependent fashion. Sensitivity to EGCG varied with each cell line with an IC50 of 15uM for UM-UC-3 as compared to 25uM for RT4 and 30 uM for TCC 96-1. EGCG also inhibited polyamine production with a dose-dependent reduction in levels of putrescine, spermidine, and spermine of 81%, 78% and 65% respectively for TCC 96-1. A reduction in polyamine levels of 62%, 34%, and 34% respectively was also observed for UM-UC-3 whereas a smaller decrease of 22% and 37% in spermidine and spermine was noted in RT-4 cells.CONCLUSION: The relatively non-toxic green tea metabolite EGCG produced growth inhibition of human bladder cancer cells associated with a significant reduction in polyamine levels. The role of polyamines in mediating the effects of EGCG in premalignant and malignant urothelium remains to be determined. These findings support the further investigation of EGCG in bladder cancer prevention.
Cancer during pregnancy: A multicentric study.
Authors: Giulia Zatta, Nicola Milite, Maria Ornella Nicoletto, Cristina Ghiotto, Paolo Tumaini, Tiziano Maggino, Egle Perissinotto, Giovanni B. Nardelli, Pier Franco Conte
Journal: Journal of Clinical Oncology (2014)

e12519 Background: Cancer is diagnosed in approximately 0.1% of pregnancies, but is expected to rise in the coming years due to the increase in childbearing age. We sought to investigate both incidence and outcome for women diagnosed during pregnancy and one year after childbearing. Materials and Methods: In a multi-center study from 2000 to 2013 we identified 119 women who were diagnosed with cancer during pregnancy or within one year postpartum. Information was obtained regarding the histology of each woman’s cancer, time of diagnosis, obstetric and neonatal outcome, and disease status. Results: The most common cancers during pregnancy are breast (36.4%), gynecological (33.1%), and thyroid cancers (9.3%). Patients miscarried most frequently (1.8%) when cancer was diagnosed during the first trimester; 31.6% of neoplasms were diagnosed in the first trimester, 49.7% in the second, 14% in the third and 24.6% postpartum. Postpartum diagnosis most often occurred within 2 months. In our population both the incidence of cancer and stage of disease at diagnosis increased with maternal age. At birth, the proportion of newborns who were underweight (29.8%) exceeded that of the general population, but reflected gestational age since deliveries more frequently occurred before week 37 and were more often by cesarean section (47.2%). Conclusions: When possible a spontaneous vaginal delivery is recommended or caesarian section after the 35th week of gestation, to insure the best possible outcome for the child. Termination of pregnancy does not insure a better prognosis for the mothers.
Prevalence and circumstances of forced sex and post-migration HIV acquisition in sub-Saharan African migrant women in France: an analysis of the ANRS-PARCOURS retrospective population-based study
Authors: Julie Pannetier, Andrainolo Ravalihasy, Nathalie Lydié, France Lert, Annabel Desgrées du Loû
Journal: The Lancet Public Health (2017)

BackgroundSub-Saharan African migrant women are a key population at risk of HIV infection in Europe. Using data from the ANRS-PARCOURS study, we aimed to assess the prevalence of forced sex after migration and its association with post-migration acquisition of HIV as well as the circumstances of forced sex after migration, including housing and administrative insecurity, among sub-Saharan African migrant women living in the Paris Region, France.MethodsThe ANRS-PARCOURS study was a retrospective life-event survey done between February, 2012, and May, 2013, in health-care facilities in the Paris region of France. Women were eligible if they were born in sub-Saharan Africa, aged between 18 and 59 years, and had been diagnosed with HIV infection at least 3 months earlier for women receiving HIV care or not diagnosed with HIV. In this analysis, we used ANRS-PARCOURS study data to compare the incidence of forced sex after migration in three groups of sub-Saharan African migrant women: those who acquired HIV after migrating, those who acquired HIV before migrating, and those without HIV. We assessed the associations between forced sex, sexual partnerships, and living conditions after migration with mixed-effects logistic regression and generalised structural equation models. The study is registered with ClinicalTrials.gov, number NCT02566148.FindingsWe obtained data from 980 eligible individuals who participated in the ANRS-PARCOURS study (407 without HIV and 573 HIV-positive) from 54 randomly selected health-care facilities. We excluded 20 women whose HIV infection could not be dated and eight women with missing data from the analyses, for a total of 405 women in the reference group (without HIV) and 547 women in the HIV group (156 with post-migration HIV acquisition, 391 with pre-migration HIV). Women who acquired HIV after migration experienced forced sex after migration more frequently than women without HIV (24 [15%] vs 18 [4%]; p=0·001). Forced sex after migration was associated with being hosted by family or friends (β=0·95, 95% CI 0·19–1·72) and lack of stable housing (β=1·10, 0·17–2·03). Lack of a residence permit was also associated with forced sex after migration.InterpretationThe social hardships faced by sub-Saharan African migrant women after migration, especially a lack of housing or lack of a residence permit, increases their exposure to sexual violence and to HIV infection.FundingThe French National Agency for Research on AIDS and Viral Hepatitis, Santé publique France, the national public health agency.
The role of positron emission tomography fused with computed tomography (PET/CT) versus CT alone in detecting oligoprogressive disease (OPD) in oncogene-addicted non-small cell lung cancer (NSCLC) receiving tyrosine kinase inhibitor (TKI) therapy.
Authors: Terry L. Ng, Rustain Morgan, Tejas Patil, Anna E. Barón, D. Ross Camidge
Journal: Journal of Clinical Oncology (2017)

e20683 Background: OPD represents limited extra-central nervous system (eCNS) progression. In oncogene-addicted NSCLC, OPD can be treated with local ablative therapy to prolong TKI control. The impact of PET/CT vs CT to detect OPD at first eCNS progression has not been assessed previously. Methods: Patients with metastatic EGFR-mutant (EGFR-MT), ALK or ROS-1 rearranged (ALK+, ROS-1+) NSCLC with eCNS progression on a relevant TKI (2010-2016) were identified. Scan methodology at first eCNS progression was noted and progression was categorized as OPD using 2 definitions (≤ 2 or ≤ 4 progressing lesions) or non-OPD. Median time-to-progression (MTTP) was calculated from start of TKI to first eCNS progression. Data was analyzed using Chi squared and log rank tests as appropriate using p &lt; 0.05 as significant. Results: Sixty-seven patients (EGFR-MT = 37, ALK+ = 28, ROS-1 = 2) were analyzable. OPD (≤ 2 lesions) occurred in 62.5% (20/32) noted by PET/CT vs. 54.3 % (19/35) by CT (p = 0.496). OPD (≤ 4 lesions) occurred in 84.4 % (27/32) noted by PET/CT vs. 65.7 % (23/35) by CT (p = 0.080). MTTP in PET/CT-detected OPD (≤ 2) (N = 20) was 332.5 days vs. 143 days in CT-detected OPD (N = 19) (p = 0.0092). MTTP in PET/CT-detected non-OPD ( &gt; 2) (N = 12) was 185 days vs. 109 days in CT-detected non-OPD (N = 17) (p = 0.0503). MTTP in PET/CT-detected OPD (≤ 4) (N = 27) was 298 days vs. 143 days in CT-detected OPD (N = 23) (p = 0.0128). MTTP in PET/CT-detected non-OPD ( &gt; 4) (N = 5) was 167 days vs. 104.5 days in CT-detected non-OPD (N = 12) (p = 0.1090). Conclusions: In this non-randomized retrospective study the proportion of OPD (≤ 2 or ≤ 4 progressing lesions) at first eCNS progression did not differ significantly for PET/CT vs. CT. MTTP was significantly longer for PET/CT vs CT detected OPD, but not for non-OPD progression. Potentially longer MTTP in the PET/CT OPD subgroup may reflect preselecting patients with disease difficult to detect by CT (e.g., bone/lymph node) which is more indolent. A prospective randomized study is required to assess the true impact of PET/CT vs CT on detecting OPD in oncogene-addicted NSCLC on TKI therapy.
Cardiovascular effects of hydroxychloroquine: a systematic review and meta-analysis
Authors: Young Ho Lee
Journal: Annals of the Rheumatic Diseases (2017)

I have read with interest the article by Mathieu and colleagues1 regarding the cardiovascular effects of hydroxychloroquine (HCQ). This systematic review and meta-analysis demonstrates that HCQ treatment is associated with an improved cardiovascular risk profile. However, it has some methodological issues. First, although the authors searched conference abstracts, using the MEDLINE database alone may not …
P2.07-027 Efficacy and Safety of Nivolumab Therapy for Advanced NSCLC in the Expanded Access Named Patient Program in Taiwan
Authors: B. Liao, C. Chiang, P. Chen, Y. Shen, W. Chen, J. Hung, K. Rau, C. Lai, C. Chen, Y. Kuo, Y. Tsai, S. Wu, C. Lin, Y. Wei, M. Wu, S. Tsao, T.C. Tsao, C. Ho, Y. Feng, C. Tsao, M. Lin, I. Chong, T. Hsia, N. Chu, Y. Chen, C. Yu, J.C. Yang
Journal: Journal of Thoracic Oncology (2017)
The relationship between priming and linguistic representations is mediated by processing constraints
Authors: L. Robert Slevc, Iva Ivanova
Journal: Behavioral and Brain Sciences (2017)

Abstract Understanding the nature of linguistic representations undoubtedly will benefit from multiple types of evidence, including structural priming. Here, we argue that successfully gaining linguistic insights from structural priming requires us to better understand (1) the precise mappings between linguistic input and comprehenders' syntactic knowledge; and (2) the role of cognitive faculties such as memory and attention in structural priming.
P2.07-029 CheckMate 169: Safety/Efficacy of Nivolumab in Canadian Pretreated Advanced NSCLC (including Elderly and PS 2) Patients
Authors: R. Juergens, Q. Chu, J. Rothenstein, F. De Angelis, S. Banerji, K. Marquis, D. Sauciuc, P. Begin, N. Finn, V. Hirsh, A. Faghih, J. Yun, A. Li, A. Acevedo, L. Musallam, P. Cheema
Journal: Journal of Thoracic Oncology (2017)
OC-085 Endoscopic revision of gastric bypass using apollo overstitch
Authors: S Thayalasekaran, K Kandiah, F Chedgy, S Subramaniam, N Carter, S Toh, P Bhandari
Journal: Gut (2017)

Introduction  Obesity is an increasing health problem worldwide. Roux-en-Y gastric bypass can produce a 56%–66% wt loss 2 years after surgery. Roughly 20% of patients fail to achieve 50% wt loss in the 1 st year after gastric bypass. Furthermore, 30% of patients regain weight 18 to 24 months after bypass. Revision surgery can be very challenging with higher complication and mortality rates than that of primary gastric bypass.  Endoscopic therapy has the potential to be a suitable alternative in this patient set. The overstitch endoscopic suturing system (Apollo Endosurgery, Austin, Texas) is a disposable, single-use, in vivo reloadable device that is mounted onto a double channel gastroscope that enables suture application.  Method  We present a video and discuss the technical details of roux-en-y gastric bypass revision using the Apollo OverStitch. The procedure steps include (video): 1. OverStitch Endoscopic Suturing System Overview 2. Argon Plasma Coagulation (APC) application to the margins of the gastrojejunal anastomosis 3. Placement of sutures using the OverStitch system.  Results  A 28 year old female, 2 years after Roux-en-Y gastric bypass presented with increasing weight gain to 190 kg. Past medical history includes mild depression and moderate anxiety. A diagnostic OGD showed a very patent gastrojejunostomy anastomosis, measuring approximately 20 mm across. Endoscopic revision of the bypass anastomosis was performed using the Apollo OverStitch to encourage weight loss.  The procedure was performed under a general anaesthesia, and involved the placement of an overtube. APC using a straight firing catheter at 1 litre/min (40 watts) was applied to the margin of the gastrojejunal anastomosis. 6 sutures were placed using the EndoStitch system to approximate the interior borders of the anastomosis with good results. There were no immediate complications. 8 months after placement of Apollo OverStitch, weight remained at 179 kg.  Conclusion  In one study of 25 patients where the OverStitch was used for revision of gastric bypass, patients lost an average of 11.7 kg at 6 months. Our case highlighed similar weight loss of 11 kg at 8 months.  References  . http://apolloendo.com/overstitch/  . Endoscopic therapy for weight loss: Gastroplasty, duodenal sleeves, intragastric balloons, and aspiration. Nitin Kumar. World Journal of Gastroenterology. Jul’15.  . Jirapinyo P, Slattery. J, et al. Evaluation of an endoscopic suturing device for transoral outlet reduction in patients with weight regain following Roux-en-Y gastric bypass. Endoscopy2013; 45:532–536.  Disclosure of Interest  None Declared
Abstract 1903: Noninvasive Assessment of the Coronary Plaque Characteristics in Culprit Lesion of Unstable Angina Pectoris by Multislice Computed Tomographic Coronary Angiography
Authors: Ryo Nakazato, Masao Moroi, Kaoru Sugi
Journal: Circulation (2007)

Background:  Intravascular ultrasound studies show that patients with unstable angina pectoris (UAP) more frequently have soft plaques in the culprit coronary artery compared with those with stable angina pectoris (SAP).   Purpose:  We evaluated plaque characteristics of a culprit lesion in patients with UAP by multislice computed tomographic coronary angiography (MSCTA).   Methods:  MSCTA (Aquillion 64, Toshiba Medical Systems, Japan) was performed in consecutive 30 patients with coronary artery disease (UAP=14, SAP=16) before percutaneous coronary intervention (PCI). Coronary plaque area was measured by manual tracing as the difference between the vessel area (inside area of the external elastic membrane) and the lumen area at the site of maximal lumen narrowing on cross-sectional MSCTA images where PCI was performed. In this plaque area, low density plaque area (a mean CT density less than 50 Hounsfield units) was automatically traced and measured.   Results:  As shown in table, although there was no difference of culprit plaque area between UAP and SAP, low density plaque area was significantly greater in UAP than SAP. Serum levels of high-sensitivity C-reactive protein (hsCRP) are 2.3mg/L in UAP patients and 0.7mg/L in SAP patients (p=0.006).   Conclusion:  On noninvasive MSCTA images, greater area of low density plaque in the culprit coronary lesion and elevated hsCRP are associated with UAP rather than SAP.
Insulin Analogues and Hypoglycemia in Patients With Type 1 Diabetes—Reply
Authors: Wendy Lane, Timothy S. Bailey, Gregg Gerety
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence of palmar-plantar erythrodysesthesia and hypothyroidism in patients with metastatic cancer treated with cabozantinib: A systematic review and meta-analysis of randomized controlled trials.
Authors: Kyaw Zin Thein, Myo Zaw, Myat M. Han, Jirapat Teerakanok, Catherine Jones, Lukman Tijani, Fred L. Hardwicke
Journal: Journal of Clinical Oncology (2017)

204 Background: Cabozantinib is an oral inhibitor of multiple tyrosine kinases, including VEGFR, KIT, RET and MET, and is proven to be beneficial in different types of tumors. Nevertheless, there are noteworthy safety concerns. We performed a systematic review and meta-analysis of randomized controlled trials (RCT) to determine the risk of palmar-plantar erythrodysesthesia (PPE) and hypothyroidism among patients with metastatic cancer treated with cabozantinib. Methods: We systematically conducted a comprehensive literature search using MEDLINE, EMBASE databases and meeting abstracts through January 31, 2017. The randomized controlled phase 3 trials that mention PPE and hypothyroidism as adverse effects were incorporated in the analysis. Mantel-Haenszel method was used to calculate the estimated pooled risk ratio (RR), and risk difference (RD) with 95% confidence interval (CI). Random effects model was applied. Results: Three phase 3 RCTs with a total of 1999 patients were eligible for analysis. Studies compared cabozantinib (C) vs everolimus, C vs placebo, C vs prednisone, were included in the analysis. All grade-PPE incidence was 499 (36.6%) in cabozantinib arm vs 26 (3.36%) in control arm with a RR of 13.998 (95% CI: 5.409 – 36.224, P &lt; 0.0001). The absolute RD was 0.374 (95% CI: 0.258 – 0.489, P &lt; 0.0001). High-grade PPE was reported in 93 (7.58%) in cabozantinib group vs 3 (0.39%) in control group with a RR of 12.486 (95% CI: 4.529 – 34.426, P &lt; 0.0001). The RD was 0.080 (95% CI: 0.045 – 0.115, P &lt; 0.0001). The overall incidence of hypothyroidism was noted in 292 (23.82%) in cabozantinib arm vs 24 (3.1%) in control arm. The pooled RR of hypothyroidism was 15.825 (95% CI: 1.229 – 203.820, P = 0.034) and RD was 0.237 (95% CI: 0.113 – 0.361, P &lt; 0.0001). Conclusions: Our meta-analysis demonstrated that cabozantinib contributed to significant toxicity of all-grade and high-grade PPE as well as hypothyroidism. Identifying these toxicities may aide physicians in providing good supportive care and patients’ quality of life.
Abstract 15994: Relationship Between Right Atrial Pressure With Jugular Flow in an Asphyxial Model of Pseudo-Pulseless Electrical Activity in Swine
Authors: Norman Paradis, Karen Moodie, Sarah Crockett, Jeffrey R Gould, Christopher L Kaufman
Journal: Circulation (2017)

Introduction: The initial cardiac rhythms found during in-hospital respiratory arrests are typically either pulseless electrical activity (PEA) or asystole. Pseudo-PEA (p-PEA) often precedes true P...
Prepregnancy Obesity and Severe Maternal Morbidity
Authors: Aaron B. Caughey
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal