tbuckley/cabot-search huggingface dataset:
Manejo de la fiebre hemorrágica vírica en los Países Bajos
Authors: C Swaan, P J. van den Broek, S Wijnands, J. E. van Steenbergen
Journal: Eurosurveillance (2002)

Desde que las fiebres hemorragicas viricas se convirtieron en enfermedades de declaracion obligatoria en 1978, en los Paises Bajos se han declarado dos casos de fiebre de Lassa. En 1980, una persona originaria de Burkina Faso que no estaba gravemente enferma recibio confirmacion de la enfermedad por analisis de laboratorio tras haber recibido el alta hospitalaria. El segundo caso se produjo en 2000: el paciente murio tras once dias de hospitalizacion. Los problemas que tuvimos que resolver a la hora de conducir este caso y la investigacion de contactos, que totalizaron mas de cien, pusieron de manifiesto la necesidad de elaborar unas recomendaciones de ambito nacional para los Paises Bajos.
Near-infrared Intraoperative Imaging of Thoracic Sympathetic Nerves: From Preclinical Study to Clinical Trial
Authors: Kunshan He, Jian Zhou, Fan Yang, Chongwei Chi, Hao Li, Yamin Mao, Bengang Hui, Kun Wang, Jie Tian, Jun Wang
Journal: Theranostics (2017)

The sympathetic nervous system controls and regulates the activities of the heart and other organs. Sympathetic nervous system dysfunction leads to disease. Therefore, intraoperative real-time imaging of thoracic sympathetic nerves (ITSN) would be of great clinical significance for diagnosis and therapy. The aim of this experimental study was to evaluate the feasibility and validity of intraoperative ITSN using indocyanine green (ICG).
Blockade of Treg Cell Differentiation and Function by the Interleukin‐21–Mechanistic Target of Rapamycin Axis Via Suppression of Autophagy in Patients With Systemic Lupus Erythematosus
Authors: Hiroshi Kato, Andras Perl
Journal: Arthritis & Rheumatology (2017)

Objective The mechanistic target of rapamycin (mTOR) has become a therapeutic target in systemic lupus erythematosus (SLE). In T cells, mTOR plays a central role in lineage specification, including development of regulatory cells (Treg cells). This study sought to investigate whether mTOR is activated within Treg cells and whether this contributes to the depletion and dysfunction of Treg cells in patients with SLE. Methods Activities of mTOR complexes 1 (mTORC1) and 2 (mTORC2) were examined by quantifying phosphorylation of translation initiation factor 4E–binding protein 1, S6 kinase, and Akt in SLE patients relative to age‐ and sex‐matched female healthy control subjects. Polarization of Treg cells from naive CD4+ T cells was assessed in the presence of interleukin‐6 (IL‐6), IL‐17, and IL‐21. The suppressor function of sorted CD4+CD25+ Treg cells was measured by determining their impact on the proliferation of autologous CD4+CD25− responder T cells. Treg cell expression of FoxP3, GATA‐3, and CTLA‐4 was monitored by flow cytometry. Autophagy was assessed using immunoblotting of light chain 3 lipidation. The effect of mTOR blockade was evaluated by testing the impact of rapamycin treatment on Treg cell function. Results SLE Treg cells exhibited increased activities of mTORC1 and mTORC2, whereas autophagy, the expression of GATA‐3 and CTLA‐4, and the suppressor function of Treg cells were diminished. IL‐21, but not IL‐6 or IL‐17, blocked the development of Treg cells. IL‐21 stimulated mTORC1 and mTORC2, and it abrogated the autophagy, differentiation, and function of Treg cells. Moreover, IL‐21 constrained the expression of GATA‐3 and CTLA‐4 selectively in Treg cells. In turn, blockade of mTORC1 by 3‐day rapamycin treatment enhanced transforming growth factor β production, while dual blockade of mTORC1 and mTORC2 by 4‐week rapamycin treatment induced autophagy, restored the expression of GATA‐3 and CTLA‐4, and corrected Treg cell function. Conclusion IL‐21–driven mTOR activation is a pharmacologically targetable checkpoint of the deficient autophagy that underlies Treg cell dysfunction in SLE.
Early specialist palliative care for all hospitalized advanced cancer patients (ACP)? Effect of “up-front” versus “on demand” palliative care on outcomes.
Authors: Monica Malec, Fay J. Hlubocky, Stacie K. Levine, Kristen Wroblewski, Ashley Thomas, Bradford Lane, William Dale, Christopher Daugherty
Journal: Journal of Clinical Oncology (2017)

172 Background: Palliative care improves outcomes for cancer patients, especially those with advanced disease. Optimal timing for initiation of specialist palliative care remains undetermined. We created a Supportive Oncology inpatient service that integrates immediate “up-front” palliative care (IPC) consultation for selected ACP to supplement our usual oncologic care (UOC) service, which continued to utilize “on-demand” palliative care consultation. Here, we compare ACP populations and selected outcomes between these two versions of in-patient cancer care. Methods: A retrospective cohort analysis of ACP receiving either IPC or UOC between Jan 2015-Dec 2015 (N=809). ACP were compared for age, gender, race, and ethnicity. Disease severity was determined by APR DRG weight, Risk of Mortality (ROM), and Severity score. Outcomes included examining differences between groups for: Length of stay (LOS), Cost, and 30 day readmission rate. Univariate and multivariate analysis were employed. Results: 468 ACP were admitted to IPC and 341 to UOC. Compared with UOC, ACP assigned to IPC were significantly younger (61.1±13.2 vs 63.3±13.0, p=0.02); more likely female (50% vs 40%, P=0.005); and more likely to be AA (47% vs 35%, P=0.005). After adjusting for gender, age, race, and encounter type, ACP receiving IPC had higher ROM (52% v 47%, p=0.03). There were no differences in APR DRG weight (p=0.30) or Severity scores (p=0.34). IPC had significantly lower costs ($12,050 vs $15,990, p=0.003), less 30-day readmissions (16% vs 23%, p=0.03), and a trend toward shorter LOS (5.6 ± 4.9 vs 6.2 ± 6.5, p=0.10). Hospice referral and survival data will be presented. Conclusions: Our data provides additional evidence for the benefits of earlier specialist palliative care consultation services, including patients traditionally identified as underserved.
Clinical utility of 18F-FDG PET for chemotherapy response evaluation in patients with malignant pleural mesothelioma
Authors: S. Kanemura, K. Kuribayashi, E. Fujimoto, Y. Negi, Y. Koda, K. Mikami, T. Minami, T. Yokoi, T. Kijima
Journal: Annals of Oncology (2017)
Abstract 14528: Effects of Organic and Inorganic Nitrate on Aortic and Carotid Hemodynamics in Heart Failure and Preserved Ejection Fraction
Authors: Julio A Chirinos, Francisco Londono-Hoyos, Melissa Beraun, Philip Haines, Izzah, Swapna Varakantam, Timothy S Phan, Thomas P Cappola, Kenneth B Margulies, Raymond R Townsend, Patrick Segers, Payman Zamani
Journal: Circulation (2016)

Background:  Organic nitrate therapy reduces physical activity, without enhancing exercise capacity in heart failure with preserved ejection fraction (HFpEF). In contrast, inorganic nitrate therapy increases exercise capacity in HFpEF. We assessed the effects of organic and inorganic nitrates on: (1) wave reflections arriving at the central aorta; (2) Carotid bed vascular properties, in HFpEF.   Methods:  Carotid and aortic pressure-flow relations were studied before and after the administration of 0.4 mg of sublingual nitroglycerin (NTG; n=26). We also performed a placebo-controlled cross-over trial of a single dose of inorganic nitrate administration (12.9 mmil; n=16).   Results:  NTG did not consistently reduce wave reflections arriving at the proximal aorta across the first 3 harmonics (change in real part of reflection coefficient, 1st harmonic:-0.09;  P =0.01; 2nd harmonic:-0.045,  P =0.16; 3rd harmonic:+0.087;  P =0.05), but produced profound vasodilation in the carotid territory, with a marked reduction in carotid bed vascular resistance (14092 vs. 11024 dynes·s/cm 5 ;  P =0.007) and carotid artery characteristic impedance (2555 vs. 1663 dynes·s/cm 5 ;  P =0.007). Inorganic nitrate administration, in contrast, produced consistent reductions in wave reflections across the first 3 harmonics (change in real part of reflection coefficient, 1st harmonic: -0.12;  P =0.03; 2nd harmonic:-0.11,  P =0.01; 3rd harmonic:-0.087;  P =0.09) and did not reduce carotid bed vascular resistance (12819 vs. 13175 dynes·s/cm 5 ;  P =0.80) or carotid artery characteristic impedance (2221 vs. 2138 dynes·s/cm 5 ;  P =0.71).   Conclusions:  NTG produces marked vasodilation in the carotid circulation, with inconsistent effects on wave reflections arriving at the central aorta. Inorganic nitrate, in contrast, produces consistent reductions in wave reflections arriving at the central aorta, without significant cerebrovascular dilatation. These hemodynamic differences may underlie the different effects on exercise capacity and side effect profile of inorganic vs. organic nitrate in HFpEF.
Priming is swell, but it's far from simple
Authors: Jayden Ziegler, Jesse Snedeker, Eva Wittenberg
Journal: Behavioral and Brain Sciences (2017)

Abstract Clearly, structural priming is a valuable tool for probing linguistic representation. But we don't think that the existing results provide strong support for Branigan &amp; Pickering's (B&amp;P's) model, largely because the priming effects are more confusing and diverse than their theory would suggest. Fortunately, there are a number of other experimental tools available, and linguists are increasingly making use of them.
Últimas tendencias registradas en la gonorrea: ¿recobra su importancia para la salud pública?
Authors: G Hughes, K. A. Fenton
Journal: Eurosurveillance (2000)

En muchos paises industrializados, la infeccion por Neisseria gonorrhoea sigue siendo una de las enfermedades de transmision sexual (ETS) mas frecuentes. Su elevada incidencia en las poblaciones de zonas urbanas deprimidas y su asociacion a la infertilidad han convertido su control en un tema prioritario para la salud publica (1). Las infecciones incidentes indican comportamientos sexuales de riesgo relativamente recientes y se han utilizado para estudiar los comportamientos que puedan favorecer la transmision del VIH (2). En este numero de Eurosurveillance, Veronique Goulet y sus colegas notifican el aumento repentino que la gonorrea experimento en Francia en 1998 y que pudo identificarse gracias a RENAGO (Reseau National du Gonocoque), la red de vigilancia nacional por laboratorios. Otro aumento similar de gonorrea registrado en Inglaterra en 1996 (3) continuo en 1997 (4). En ambos paises, los aumentos observados fueron especialmente alarmantes por haber surgido tras una prolongada disminucion desde mediados hasta finales de los anos ochenta. ?Como debemos interpretar estos aumentos? ?Nos indican, quizas, un retorno a comportamientos sexuales pocos seguros?
Japan’s government warns against abnormal behaviour in people taking antivirals for flu
Authors: Nigel Hawkes
Journal: BMJ (2017)

Local authorities in Japan have been told to take precautions to avoid accidental injury among people with influenza this winter, after the Ministry of Health, Labour, and Welfare reported 54 cases of abnormal behaviour last season among people taking antivirals.

They included two young people who died after jumping from buildings while taking zanamivir (Relenza), the Japan Times reported.1 In most of the cases—38 of the 54—the drug involved was oseltamivir (Tamiflu).

The suggested precautions included installing extra locks on windows and …
The humanness of artificial non-normative personalities
Authors: Kevin B. Clark
Journal: Behavioral and Brain Sciences (2017)

Abstract Technoscientific ambitions for perfecting human-like machines, by advancing state-of-the-art neuromorphic architectures and cognitive computing, may end in ironic regret without pondering the humanness of fallible artificial non-normative personalities. Self-organizing artificial personalities individualize machine performance and identity through fuzzy conscientiousness, emotionality, extraversion/introversion, and other traits, rendering insights into technology-assisted human evolution, robot ethology/pedagogy, and best practices against unwanted autonomous machine behavior.
Dermatology Practice Consolidation Fueled by Private Equity Investment
Authors: Jack S. Resneck
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Phase III safety evaluation of intravenous NEPA, a novel fixed antiemetic combination of fosnetupitant and palonosetron, over multiple cycles.
Authors: Lee Steven Schwartzberg, Zoran Gojko Andric, Dariusz Kowalski, Daniel Voisin, Giada Rizzi, Meinolf Karthaus
Journal: Journal of Clinical Oncology (2017)

122 Background: NEPA is an oral fixed combination of the selective NK 1 receptor antagonist (RA), netupitant (300 mg), and pharmacologically distinct 5-HT 3 RA, palonosetron (PALO 0.50 mg), combining two guideline-recommended antiemetic classes in a convenient single capsule. Oral NEPA has shown superior prevention of chemotherapy-induced nausea and vomiting (CINV) over oral PALO, sustained efficacy over multiple cycles, and well-established safety in &gt;1500 patients (pts). To offer additional convenience for health care practitioners and pts, an intravenous (IV) formulation of the NEPA fixed combination (fosnetupitant 235 mg/PALO 0.25 mg) was developed. Methods: This randomized, multinational, double-blind, stratified (by gender/country) phase 3 study in chemotherapy-naïve pts with solid tumors was designed to assess the safety of a single 30-minute infusion of IV NEPA prior to initial/up to 4 repeated cycles of highly emetogenic chemotherapy (HEC). Patients received either IV NEPA or oral NEPA, both with oral dexamethasone on days 1-4. Safety was assessed by treatment-emergent adverse events (TEAEs), laboratory tests, vital signs and ECGs. Results: 404 pts were evaluated for a total of 1312 exposures. Overall, 53% of pts were male with a mean age of 60 years; 99% of pts were white and cisplatin-containing regimen was the HEC for 96% of pts; lung cancer was the most common tumor (55% pts). The AE profiles were similar for both groups in cycle 1 and across all cycles (See Table), with no increased incidence of AEs in subsequent cycles. No infusion site reactions related to IV NEPA occurred. No clinically relevant changes in QTcor cardiac safety concerns were observed. Conclusions: IV NEPA is safe and well-tolerated over multiple cycles with a similar safety profile to oral NEPA in pts receiving HEC. Clinical trial information: NCT02517021. [Table: see text]
Inducible Knockdown of c-Jun N-terminal Kinase-2 (Jnk2) in hepatocytes has a stage dependent effect on disease progression
Authors: Marius M. Woitok, Fabian Kießling, Francisco Javier Cubero, Christian Trautwein, Dennis Doleschel, Wiltrud Lederle, Miguel Eugenio Zoubek
Journal: Hepatology (2017)
Efficacy, safety and health-related quality of life with epirubicin, cisplatin plus 5-FU (ECF) and docetaxel, cisplatin plus 5-FU (DCF) regimens as first-line systemic chemotherapy in metastatic gastric cancer: Final results of a phase II study
Authors: T. Chaudhuri, K.G. Babu, K.C. Lakshmaiah, L. Dasappa, L.A. Jacob, M.C.S. Babu, A.H. Rudresha, K.N. Lokesh, L.K. Rajeev
Journal: Annals of Oncology (2017)
Triple threat of mortality among advance cancer patients presenting to an emergency department.
Authors: Ahmed F. Elsayem, Carla L. Warneke, Cielito C. Reyes-Gibby, Valda D Page, Luke Joseph Buffardi, Patricia A. Brock, Patrick Chaftari, Kumar Alagappan
Journal: Journal of Clinical Oncology (2017)

138 Background: Early identification of cancer patients with short survival will help address end of life issues and avoid costly interventions. Dyspnea, delirium, and poor performance are known to predict short survival in palliative care. Our goal is to test whether these 3 conditions could predict mortality in the emergency department (ED) setting because a shorter tool would be practical. Methods: We randomly selected 243 English-speaking patients with advanced cancer who presented to the MD Anderson hospital ED and who were judged clinically stable. Patients were assessed for the presence of delirium (Confusion Assessment Method and Memorial Delirium Assessment Scale), poor performance (Eastern Cooperative Oncology Group score 3 or 4), and dyspnea (MD Anderson Symptom Inventory shortness of breath score &gt; 5). All measures (survival and symptom) were available for 212 patients. Triple threat was defined as the presence of one of more of the 3 conditions: delirium (by either tool), poor performance, or dyspnea. We obtained survival data from medical records. Results: The table below shows each condition frequency, predicted probability of 30-day survival, and median OS. In pairwise comparisons adjusting for multiple comparisons, participants with 2 or more of the symptoms had poorer 30-day survival and OS. Conclusions: Patients with advanced cancer who have at least two of the triple threat conditions should have early discussion of goals of care to avoid costly and aggressive interventions. Further research including clinically unstable patients should be performed. [Table: see text]
Abstract 18570: Real-Time in vivo Imaging of Reactive Oxygen Species (ROS) Dynamics in Murine Carotid Atheroma Using Novel ROS-Responsive NIRF Emitting Sensor
Authors: Eun Jin Park, Chang-Soo Kim, Ji Bak Kim, Bong Gu Yi, Joon Woo Song, Hyun Jung Kim, Joo Hee Jeon, Dong Joo Oh, Hongki Yoo, Kyeongsoon Park, Jin Won Kim
Journal: Circulation (2016)

Introduction and Hypothesis: Excessive oxidative stress with reactive oxygen species (ROS) has been implicated in the pathogenesis of atherosclerosis, but only few studies have ever imaged ROS in a...
Abstract 19469: Quadripolar Left Ventricular Leads are Less likely to Dislodge or Require Repositioning
Authors: Shasank Rijal, Andrew D Althouse, Rohit Rattan, Jonathan Wolfe, Oscar C Marroquin, Suresh R Mulukutla, Samir Saba
Journal: Circulation (2015)

Objective: Since quadripolar left ventricular (LV) leads allow pacing from multiple electrodes, they are less likely than other leads to be placed in unstable positions in order to optimize electrical pacing parameters. We therefore investigated the rate of lead revision and dislodgement in quadripolar (QUAD) vs. bipolar (BI) LV lead recipients. Methods: We retrospectively collected data for N=545 patients at our institution implanted with QUAD (n=173) vs. BI (n=372) LV leads from 2012-2014 and followed them to the endpoint of LV lead revision or lead dislodgement in the first 6 months after implantation. Time to event was analyzed by lead type using Kaplan-Meier curves, log-rank tests, and Cox proportional-hazards models. Results: The cohort was aged 69.6 ± 11.5 years, 89.3% white, with mean BMI 29.8 ± 6.3 kg/m2. Patients were mostly NYHA Class III heart failure (55.7%), while 47.4% had diabetes, 78.9% had hypertension, and 50.8% had atrial fibrillation. Baseline characteristics were comparable in patients that received QUAD and BI leads. Patients receiving BI leads were more likely to require lead revisions during the index hospitalization (BI: 4.8% vs. QUAD: 1.1%, P=0.03). In the first 6 months of follow-up, patients getting QUAD leads had a significantly lower rate of LV lead dislodgement (7.0% vs. 1.7%, P&lt;0.01, see Figure). In a multivariate model adjusted for age, diabetes, prior history of MI, atrial fibrillation, and NYHA class, the difference persisted (HR=0.26, 95% CI [0.08, 0.85], P=0.02). Conclusions: Quadripolar LV leads are less likely to dislodge or require lead revision during the index hospitalization or follow-up. These results have important clinical implications
Validation of the Psoriatic Arthritis Impact of Disease (PsAID) Questionnaire and its potential as a single-item outcome measure in clinical practice
Authors: Richard Holland, William Tillett, Eleanor Korendowych, Charlotte Cavill, Nicola Waldron, Melanie Brooke, Neil J McHugh
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Objectives</h3> The Psoriatic Arthritis Impact of Disease (PsAID) Questionnaire is a recently developed patient-reported outcome measure (PROM) of disease impact in psoriatic arthritis (PsA). We set out to assess the validity in an independent cohort of patients, estimate the minimally important difference for improvement and explore the potential of individual components of the PsAID in clinical practice. <h3>Methods</h3> Data were collected prospectively for a single-centre cohort of patients with PsA. Construct validity was assessed by Spearman correlation with other PROMs and reliability by intraclass correlation coefficient (ICC) at 1 week. Sensitivity to change at 3 months was determined by the standardised response mean (SRM) in those patients with active disease requiring a change in treatment. <h3>Results</h3> A total of 129 patients (mean ±SD age 52.1±13.3, 57% women, disease duration 10.2±8 years) completed the baseline questionnaires and assessments. The mean baseline PsAID12 score was 3.92±2.26 with an ICC of 0.91 (95%CI 0.87 to 0.94). The SE of measurement was 0.51 and the minimal detectable change was 1.41. There was strong correlation (r≥0.70) with most of the PROMs studied and moderate correlation with clinical outcomes (r=0.40–0.57). The SRM of the PsAID12 was 0.74 (95%CI 0.45 to 0.97). There was strong correlation with individual PsAID items and their corresponding PROM questionnaires (r≥0.67). <h3>Conclusion</h3> The PsAID is a reliable, feasible and discriminative measure in patients with PsA. The good responsiveness of the PsAID and strong correlation of individual items with other PROMS represent an opportunity to reduce questionnaire burden for patients in studies and clinical practice.
Abstract 20874: Long-Term Real World Experience of Left Atrial Appendage Closure With Lariat Device in Patients With Non Valvular Atrial Fibrillation - Impact on Thromboembolism, Bleeding and Mortality
Authors: Dhanunjaya Lakkireddy, Valay Parikh, Radoslaw Litwinowicz, Krzysztof Bartus, Jerzy Sadowski, Boguslaw Kapelak, Magdalena Bartus, Jakub Podolec, Krzysztof Oles, Piotr Ceranowicz, Madhu Reddy, Abdi Rasekh, Jie Cheng, Randall Lee
Journal: Circulation (2017)

Background: Left atrial appendage closure (LAAC) with LARIAT has emerged as one of the alternatives to oral anticoagulation (OAC) in patients with non-valvular atrial fibrillation (AF). Our aim was...
Febrile neutropenia and primary prophylactics in docetaxel plus cyclophosphamide chemotherapy for breast cancer: A Japanese institution experience
Authors: Y. Kimura, S. Sasada, N. Goda, A. Emi, K. Kajitani, N. Masumoto, R. Haruta, T. Kadoya, T. Kataoka, M. Okada
Journal: Annals of Oncology (2017)