tbuckley/cabot-search huggingface dataset:
Is supine exercise associated with adverse maternal and fetal outcomes? A systematic review
Authors: Michelle F Mottola, Taniya S Nagpal, Roberta Bgeginski, Margie H Davenport, Veronica J Poitras, Casey E Gray, Gregory A Davies, Kristi B Adamo, Linda G Slater, Nick Barrowman, Ruben Barakat, Stephanie-May Ruchat
Journal: British Journal of Sports Medicine (2018)

Objective Theoretical concerns regarding the supine position at rest due to the gravid uterus obstructing aorta and vena caval flow may impinge uterine blood flow (UBF) to the fetus and maternal venous return. Design Systematic review. Data sources Online databases up to 11 December 2017. Study criteria Eligible population (pregnant without contraindication to exercise), intervention (frequency, intensity, duration, volume or type of supine exercise), comparator (no exercise or exercise in left lateral rest position, upright posture or other supine exercise), outcomes (potentially adverse effects on maternal blood pressure, cardiac output, heart rate, oxygen saturation, fetal movements, UBF, fetal heart rate (FHR) patterns; adverse events such as bradycardia, low birth weight, intrauterine growth restriction, perinatal mortality and other adverse events as documented by study authors), and study design (except case studies and reviews) published in English, Spanish, French or Portuguese. Results Seven studies (n=1759) were included. ‘Very low’ to ‘low’ quality evidence from three randomised controlled trials indicated no association between supervised exercise interventions that included supine exercise and low birth weight compared with no exercise. There was ‘very low’ to ‘low’ quality evidence from four observational studies that showed no adverse events in the mother; however, there were abnormal FHR patterns (as defined by study authors) in 20 of 65 (31%) fetuses during an acute bout of supine exercise. UBF decreased (13%) when women moved from left lateral rest to acute dynamic supine exercise. Conclusion There was insufficient evidence to ascertain whether maternal exercise in the supine position is safe or should be avoided during pregnancy.
IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability
Authors: T. Tiffany Wang, Jun Yang, Yong Zhang, Meili Zhang, Sigrid Dubois, Kevin C. Conlon, Yutaka Tagaya, Cait E. Hamele, Shubha Dighe, Thomas L. Olson, David J. Feith, Nazli Azimi, Thomas A. Waldmann, Thomas P. Loughran
Journal: Leukemia (2018)
Breathing New Life into Interstitial Lung Disease in Rheumatoid Arthritis
Authors: Peter K. Gregersen, Ellen M. Gravallese
Journal: New England Journal of Medicine (2018)

Clinical heterogeneity is a hallmark of many autoimmune disorders, and clinical or subclinical pulmonary involvement is a common extraarticular feature of the rheumatoid arthritis (RA) phenotype. High-resolution computed tomography reveals evidence of pulmonary abnormalities in more than half of patients with RA, and clinically significant interstitial lung disease (ILD) will develop in approximately 10% of patients.1 It is currently difficult to identify these patients and to intervene early in the clinical course of their lung disease. The application of genomewide association studies to the search for common genetic variants involved in autoimmune and inflammatory diseases has produced a rich harvest . . .
Hair Regrowth in a Patient With Long-standing Alopecia Totalis and Atopic Dermatitis Treated With Dupilumab
Authors: Lauren R. Penzi, Mariko Yasuda, Athena Manatis-Lornell, Dina Hagigeorges, Maryanne M. Senna
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth
Authors: Jeroni Luna, Jacopo Boni, Miriam Cuatrecasas, Xavier Bofill-De Ros, Estela Núñez-Manchón, Meritxell Gironella, Eva C Vaquero, Maria L Arbones, Susana de la Luna, Cristina Fillat
Journal: Gut (2018)

Background and aims Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumour with a poor prognosis using current treatments. Targeted therapies may offer a new avenue for more effective strategies. Dual-specificity tyrosine regulated kinase 1A (DYRK1A) is a pleiotropic kinase with contradictory roles in different tumours that is uncharacterised in PDAC. Here, we aimed to investigate the role of DYRK1A in pancreatic tumorigenesis. Design We analysed DYRK1A expression in PDAC genetic mouse models and in patient samples. DYRK1A function was assessed with knockdown experiments in pancreatic tumour cell lines and in PDAC mouse models with genetic reduction of Dyrk1a dosage. Furthermore, we explored a mechanistic model for DYRK1A activity. Results We showed that DYRK1A was highly expressed in PDAC, and that its protein level positively correlated with that of c-MET. Inhibition of DYRK1A reduced tumour progression by limiting tumour cell proliferation. DYRK1A stabilised the c-MET receptor through SPRY2, leading to prolonged activation of extracellular signal-regulated kinase signalling. Conclusions These findings reveal that DYRK1A contributes to tumour growth in PDAC, at least through regulation of c-MET accumulation, suggesting that inhibition of DYRK1A could represent a novel therapeutic target for PDAC.
Antifungal drugs: New insights in research &amp; development
Authors: André Moraes Nicola, Patrícia Albuquerque, Hugo Costa Paes, Larissa Fernandes, Fabricio F. Costa, Erika Seki Kioshima, Ana Karina Rodrigues Abadio, Anamélia Lorenzetti Bocca, Maria Sueli Felipe
Journal: Pharmacology & Therapeutics (2018)
Phase II study of osimertinib in patients with plasma EGFR T790M positive advanced lung cancer (WJOG8815L/LPS)
Authors: Takayuki Takahama, Koichi Azuma, Mototsugu Shimokawa, Terufumi Kato, Haruko Daga, Isamu Okamoto, Hiroaki Akamatsu, Toshiaki Takahashi, Tatsuo Ohira, Toshihide Yokoyama, Katsuya Hirano, Yoshimasa Shiraishi, Daisuke Himeji, Nobuyuki Yamamoto, Kazuto Nishio, Kazuhiko Nakagawa
Journal: Annals of Oncology (2018)
Decreased circulating lymphatic endothelial progenitor cells in digital ulcer-complicated systemic sclerosis
Authors: Mirko Manetti, Sara Pratesi, Eloisa Romano, Irene Rosa, Cosimo Bruni, Silvia Bellando-Randone, Serena Guiducci, Enrico Maggi, Lidia Ibba-Manneschi, Marco Matucci-Cerinic
Journal: Annals of the Rheumatic Diseases (2018)

In systemic sclerosis (SSc), the main pathogenic scenario is represented by early endothelial cell injury and microvascular desertification culminating into skin and internal organ fibrosis.1 Growing evidence suggests that impaired vascular repair and neovascularisation could be related to failure of both angiogenesis and endothelial progenitor cell (EPC)-driven vasculogenesis.2

In SSc, the majority of studies are focused on the role of blood vessel dysfunction,1 2 while the involvement of the lymphatic microcirculation has attracted much less attention. Nevertheless, clinical and histological findings have shown that lesional SSc skin displays lymphatic circulatory abnormalities.3–5 These may be present since the earliest disease phases, when digital painless swelling (puffy fingers), due to the accumulation of protein-rich interstitial fluid (ie, oedema), is a clinical hallmark.3–5 Furthermore, in SSc reduced numbers of dermal microlymphatics have been correlated with development of digital ulcers (DU) and progression of cutaneous fibrosis.4 5

Postnatal lymphatic neovascularisation takes place through lymphangiogenesis (ie, the formation of novel lymphatic vessels from pre-existing ones) and lymphvasculogenesis. This last event stems from circulating bone marrow-derived lymphatic EPC (LEPC) that differentiate into mature endothelial cells expressing lymphatic-specific markers.6 On their surface, LEPC display CD34 and CD133, likewise their blood vascular counterpart (ie, EPC), but they …
Renal effects of streptozocin: Preliminary results of the STREPTOTOX prospective study.
Authors: Emmanuel Mitry, Catherine Lombard-Bohas, Francois-Xavier Caroli-Bosc, Jean-Louis Legoux, Philippe B. Ruszniewski, Jean Francois Seitz, Eric Terrebonne, Pierre-Luc Etienne, Philippe Rougier, Hedia Brixi Benmansour, Sylvain Manfredi, Pierre Michel, Herve L. Naman, Karine Bouhier, Sophie Dominguez, Christophe Locher, Abakar-Mahamat Abakar, Karine Le Malicot, Come Lepage, Gabriel Choukroun
Journal: Journal of Clinical Oncology (2014)

e15155 Background: Based on old studies, streptozocin (STZ), used to treat gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs), is known to have some renal toxicity. We investigated the renal effects of STZ with current dosing regimens and renal surveillance in a 2-part study (retrospective and prospective part). Methods: Patients with GEP-NETS treated with STZ were included. The primary endpoint was the percentage of patients who had a decrease of estimated Glomerular Filtration Rate (eGFR) of at least 25% (MDRD formula) compared to baseline. We report here the results of the prospective part of the study. Results: 30 patients were included and evaluable (median age 64.5 [32-81] yrs, 50% men, mean eGFR 93.2 ± 23.5 ml/min, all patients had well-differenciated tumours and 87% were metastatic. 27 patients received IV STZ only, 3 intra-arterial STZ (chemoembolisation). Median number of cycles was 3 (1-12) for IV STZ. Mean eGFR remained roughly stable during treatment. 4 (15.4%) had eGFR decrease ≥ 25% compared to baseline at some point during therapy but none at the end of treatment. There was no grade 4 renal toxicity, no patient required haemodialysis. Age, KDIGO classes and cumulative dose of STZ were not associated with renal impairment in univariate analysis. Disease control was obtained for more than 90% of the patients, and 1 patient died during the study from disease progression. Conclusions: Renal function remained stable under STZ therapy and renal toxicity was not a major cause of treatment discontinuation.
Association of Caffeine Intake and Caffeinated Coffee Consumption With Risk of Incident Rosacea in Women
Authors: Suyun Li, Michael L. Chen, Aaron M. Drucker, Eunyoung Cho, Hao Geng, Abrar A. Qureshi, Wen-Qing Li
Journal: JAMA Dermatology (2018)

Caffeine is known to decrease vasodilation and have immunosuppressant effects, which may potentially decrease the risk of rosacea. However, the heat from coffee may be a trigger for rosacea flares. The relationship between the risk of rosacea and caffeine intake, including coffee consumption, is poorly understood. To determine the association between the risk of incident rosacea and caffeine intake, including coffee consumption. This cohort study included 82 737 women in the Nurses' Health Study II (NHS II), a prospective cohort established in 1989, with follow-up conducted biennially between 1991 and 2005. All analysis took place between June 2017 and June 2018. Data on coffee, tea, soda, and chocolate consumption were collected every 4 years during follow-up. Information on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005. A total of 82 737 women responded to the question regarding a diagnosis of rosacea in 2005 in NHS II and were included in the final analysis (mean [SD] age at study entry, 50.5 [4.6] years). During 1 120 051 person-years of follow-up, we identified 4945 incident cases of rosacea. After adjustment for other risk factors, we found an inverse association between increased caffeine intake and risk of rosacea (hazard ratio for the highest quintile of caffeine intake vs the lowest, 0.76; 95% CI, 0.69-0.84; P < .001 for trend). A significant inverse association with risk of rosacea was also observed for caffeinated coffee consumption (HR, 0.77 for those who consumed ≥4 servings/d vs those who consumed <1/mo; 95% CI, 0.69-0.87; P < .001 for trend), but not for decaffeinated coffee (HR, 0.80; 95% CI, 0.56-1.14; P = .39 for trend). Further analyses found that increased caffeine intake from foods other than coffee (tea, soda, and chocolate) was not significantly associated with decreased risk of rosacea. Increased caffeine intake from coffee was inversely associated with the risk of incident rosacea. Our findings do not support limiting caffeine intake as a means to prevent rosacea. Further studies are required to explain the mechanisms of action of these associations, to replicate our findings in other populations, and to explore the relationship of caffeine with different rosacea subtypes.
Association of Androgen Deprivation Therapy With Dementia in Men With Prostate Cancer Who Receive Definitive Radiation Therapy
Authors: Rishi Deka, Daniel R. Simpson, Alex K. Bryant, Vinit Nalawade, Rana McKay, J. D. Murphy, Brent S. Rose
Journal: JAMA Oncology (2018)

This cohort study examines the association of androgen deprivation therapy with dementia in male veterans with prostate cancer who receive definitive radiotherapy.
A prospective study of first-line Helicobacter pylori eradication therapy in treating localized extragastric mucosa-associated lymphoid tissue lymphoma
Authors: S.-H. Kuo, M. Yao, C.-H. Tsai, C.-W. Lin, J.-M. Liou, W.-L. Ma, A.-L. Cheng
Journal: Annals of Oncology (2018)
IgH locus suicide recombination does not depend on NHEJ in contrast to CSR in B cells
Authors: Nour Ghazzaui, Hussein Issaoui, Ophélie Alyssa Martin, Alexis Saintamand, Yves Denizot, Hend Boutouil, François Boyer, Jeanne Cook-Moreau, Michel Cogné, Sophie Péron
Journal: Cellular and Molecular Immunology (2018)
Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit
Authors: Christina M. J. E. Vandenbroucke-Grauls, Jos W. M. van der Meer
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Factors Associated With Emergency Department Use by Patients With and Without Mental Health Diagnoses
Authors: Matthew J. Niedzwiecki, Pranav J. Sharma, Hemal K. Kanzaria, Shannon McConville, Renee Y. Hsia
Journal: JAMA Network Open (2018)

<h3>Importance</h3> An association between frequent use of the emergency department (ED) and mental health diagnoses is frequently documented in the literature, but little has been done to more thoroughly understand why mental illness is associated with increased ED use. <h3>Objective</h3> To determine which factors were associated with higher ED use in the near future among patients with and without mental health diagnoses. <h3>Design, Setting, and Participants</h3> A retrospective case-control study of all patients presenting to the ED in California in 2013 using past ED data to predict future ED use. Data from January 1, 2012, through December 31, 2014, from California's Office of Statewide Health Planning and Development were analyzed. <h3>Main Outcomes and Measures</h3> Factors associated with higher ED use in the year following an index visit for patients with vs without a mental health diagnosis. <h3>Results</h3> Among the 3 446 338 individuals in the study (accounting for 7 678 706 ED visits), 44.6% (1 537 067) were male; 31.6% (1 089 043) were between the ages of 18 and 30 years, 40.3% (1 338 874) were between the ages of 31 and 50 years, and 28.1% (968 421) were between the ages of 51 and 64 years. The mean (SD) number of ED visits per patient per year was 1.69 (2.56), and 29.1% of patients (1 002 884) had at least 1 mental health diagnosis. Previous hospitalization and high rates of lagged ED visits were associated with higher future ED use. The severity of the mental health diagnosis (mild, moderate, or severe) was associated with increased ED visits (incidence rate ratio [IRR], 1.029; 95% CI, 1.02-1.04 for mild; IRR, 1.121; 95% CI, 1.11-1.13 for moderate; and IRR, 1.226; 95% CI, 1.22-1.24 for severe). Little evidence was found for interaction effects between mental health diagnoses and other diagnoses in predicting increased future ED use. <h3>Conclusions and Relevance</h3> Certain classes of mental health diagnoses were associated with higher ED use. The presence of a mental illness diagnosis did not appear to interact with other patient-level factors in a way that meaningfully altered associations with future ED use.
KEYNOTE-061: pembrolizumab vs paclitaxel for previously treated advanced gastric or gastroesophageal junction cancer
Authors: Kohei Shitara, Kei Muro, Taroh Satoh, Takao Tamura, Keisho Chin, Nozomu Machida, Hiroki Hara, Shuichi Hironaka, Naotoshi Sugimoto, Carlos Mayo, Shi Rong Han, Shinichi Shiratori, Atsushi Ohtsu
Journal: Annals of Oncology (2018)
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness
Authors: Timothy D. Girard, Matthew C. Exline, Shannon S. Carson, Catherine L. Hough, Peter Rock, Michelle N. Gong, Ivor S. Douglas, Atul Malhotra, Robert L. Owens, Daniel J. Feinstein, Babar Khan, Margaret A. Pisani, Robert C. Hyzy, Gregory A. Schmidt, William D. Schweickert, R. Duncan Hite, David L. Bowton, Andrew L. Masica, Jennifer L. Thompson, Rameela Chandrasekhar, Brenda T. Pun, Cayce Strength, Leanne M. Boehm, James C. Jackson, Pratik P. Pandharipande, Nathan E. Brummel, Christopher G. Hughes, Mayur B. Patel, Joanna L. Stollings, Gordon R. Bernard, Robert S. Dittus, E. Wesley Ely
Journal: New England Journal of Medicine (2018)

There are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive care unit (ICU).
Neurological Complications After Transcatheter Versus Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Authors: Andras P. Durko, Michael J. Reardon, Neal S. Kleiman, Jeffrey J. Popma, Nicolas M. Van Mieghem, Thomas G. Gleason, Tanvir Bajwa, Daniel O’Hair, David L. Brown, William H. Ryan, Yanping Chang, Sonia Diaz De Leon, Arie Pieter Kappetein
Journal: Journal of the American College of Cardiology (2018)
PTH-101 A manualised intervention to reduce psychological distress in inflammatory bowel disease: a pilot randomised controlled feasibility trial
Authors: LD Hughes, A Fischer, S Goodliffe, PM Irving, R Moss-Morris
Journal: Gut (2017)

Introduction  Depression and anxiety are common problems in inflammatory bowel diseases (IBD). In part due to its cost, the availability of psychological intervention for IBD patients is low. To address this, a novel IBD specific self-management manual (Quality of Life Tool for IBD - QOLITI) was developed. This was piloted with minimal therapist support. The aim of this pilot trial was to measure the feasibility and acceptability of a primarily self-administered intervention targeting IBD-related distress.  Method  A two-arm randomised control trial (NCT02707068) was conducted. Patients with a diagnosis of IBD were recruited from hospital clinics and online through the Crohn’s and Colitis UK website. Patients were randomised into either the intervention arm (n=32) or waitlist control arm (n=31). Validated questionnaire measures were administered pre and post intervention (8 weeks). The intervention arm received QOLITI, task book and three telephone support sessions. Following intervention completion, participants in the treatment arm were invited to participate in semi-structured interviews to provide feedback on the QOLITI.  Results  The mean age of the treatment group was 38 (SD=11.9) years, 59% were female, 59% had Crohn’s Disease and the mean years since diagnosis was 12.2 (SD=12.8). The mean age of the control group was 43 (SD=13.7) years, 66% were female, 50% had Crohn’s Disease and the mean years since diagnosis was 10.7 (SD=7.7). Randomisation checks indicated that participants did not differ between groups. 97% of patients approached in clinics were eligible and 50% subsequently consented. 85% of patients who began the trial were retained in the study. 80% of those in the treatment arm completed at least 1 telephone session. Semi-structured interviews with 11 participants indicated a high level of acceptability with willingness to actively engage with the manual, despite challenging tasks. The manual was generally perceived as useful with some participants reporting changing their behaviour and/or thoughts about IBD as a direct result of the tasks performed.  Conclusion  Good feasibility and acceptability was shown for a self-directed manual targeting distress. It is feasible to recruit participants from clinics and retain them through an 8 week intervention. Telephone support was helpful to guide progress through the manual. Feedback on the manual was positive and further testing following MRC guidelines will continue to test the effectiveness, cost-effectiveness and implementation of the QOLITI.  Disclosure of Interest  None Declared
A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability
Authors: Arabinda Nayak, Dong Young Kim, Michael J. Trnka, Craig H. Kerr, Peter V. Lidsky, David J. Stanley, Brianna Monique Rivera, Kathy H. Li, Alma L. Burlingame, Eric Jan, Judith Frydman, John D. Gross, Raul Andino
Journal: Cell Host & Microbe (2018)
Assessment of bleeding risk by sonoclot in acute lymphoblastic leukemia
Authors: K. Mishra, A. Jandial, A. Meshram, R. Sandal, D. Lad, G. Prakash, A.R. Khadwal, R. Dhiman, N. Varma, S.C. Varma, P. Malhotra
Journal: Annals of Oncology (2018)