tbuckley/cabot-search huggingface dataset:
Estudio de costes estándar directo de diferentes técnicas de endoscopia avanzada. Comparativa con la alternativa quirúrgica
Authors: C Loras, V Mayor, X Andújar, J Espinós, F Fernández-Bañares, M Esteve
Journal: Endoscopy (2017)

la complejidad de muchos de los procedimientos endoscópicos actuales conlleva una inevitable elevación del coste, que repercute de forma directa en la financiación de los sistemas públicos de salud. Son escasas las aportaciones publicadas que determinan el coste estándar de los procedimientos de endoscopia avanzada, y mucho menos una comparativa con la alternativa quirúrgica.
Abstract 16901: Leukotriene Production by the 5-lipoxygenase Pathway is Linked to Microvascular Dysfunction
Authors: Johannes Wikström, Daniel Karlsson, Margareta Behrendt, Sara Swedlund, Helena Westergren, Daniel Hovdal, Monika Sundquist, Anne-Christine Andréasson, Ann-Cathrine Jönsson-Rylander, Marianne Månsson, Carl Whatling, Li-ming Gan
Journal: Circulation (2016)

Introduction: 5-lipoxygenase (5-LO) and 5-lipoxygenase activating protein (FLAP) are essential for production of leukotrienes (LTs), lipid mediators with inflammatory and vasoactive actions. Inhibi...
Burden and risk factors for <i>Pseudomonas aeruginosa</i> community-acquired pneumonia: a multinational point prevalence study of hospitalised patients
Authors: Marcos I. Restrepo, Bettina L. Babu, Luis F. Reyes, James D. Chalmers, Nilam J. Soni, Oriol Sibila, Paola Faverio, Catia Cilloniz, William Rodriguez-Cintron, Stefano Aliberti
Journal: European Respiratory Journal (2018)

Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa -CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa- CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa . Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa- CAP. The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa- CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases ( i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa- CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa- CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients.
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells
Authors: Andreia C. Lino, Van Duc Dang, Vicky Lampropoulou, Anna Welle, Jara Joedicke, Jelka Pohar, Quentin Simon, Jessie Thalmensi, Aurelia Baures, Vinciane Flühler, Imme Sakwa, Ulrik Stervbo, Stefanie Ries, Luc Jouneau, Pierre Boudinot, Takeshi Tsubata, Takahiro Adachi, Andreas Hutloff, Thomas Dörner, Ursula Zimber-Strobl, Alex F. de Vos, Katja Dahlke, Gunnar Loh, Sarantis Korniotis, Christian Goosmann, Jean-Claude Weill, Claude-Agnès Reynaud, Stefan H.E. Kaufmann, Jörn Walter, Simon Fillatreau
Journal: Immunity (2018)

B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious, autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo. These plasma cells also express the inhibitory receptors CD200, PD-L1, and PD-L2. They develop from various B cell subsets in a B cell receptor (BCR)-dependent manner independently of microbiota in naive mice. After challenge they upregulate IL-10 expression via a Toll-like receptor-driven mechanism within hours and without proliferating. This function is associated with a unique transcriptome and epigenome, including the lowest amount of DNA methylation at the Il10 locus compared to other B cell subsets. Their augmented accumulation in naive mutant mice with increased BCR signaling correlates with the inhibition of memory T cell formation and vaccine efficacy after challenge. These natural regulatory plasma cells may be of broad relevance for disease intervention.
Accountable care organisations: second legal challenge fails in High Court
Authors: Ingrid Torjesen
Journal: BMJ (2018)

Campaigners have lost their High Court challenge against the secretary of state for health and social care and NHS England over plans to introduce accountable care organisations (ACOs), which they argue will allow private companies a greater role in the NHS.

The action was brought by the campaign group JR4NHS, founded by three doctors and a university professor and supported by the late scientist Stephen Hawking, on two grounds—a lack of clarity and transparency, and the legality of the idea itself. But the court found that the law did not support either of the action’s claims.

ACOs are a US invention …
EPIDEMIOLOGICAL AND LESIONAL ASPECT OF UPPER GASTROINTESTINAL BLEEDING IN CHRONIC KIDNEY FAILURE
Authors: F Errabie, A Elmekkaoui, W Khannoussi, G Kharrasse, Z Ismaili
Journal: Endoscopy (2018)

The objective of our study is to determine the epidemiological, lesional profile of upper gastrointestinal bleeding in the chronic kidney failure.
RISK OF COLORECTAL NEOPLASIA FOLLOWING COLONOSCOPIC RESECTION OF SESSILE SERRATED ADENOMA/POLYP
Authors: JS Koo, D Kim, D Lee, SY Kim, JJ Hyun, SW Jung, SW Lee
Journal: Endoscopy (2018)

The study was conducted to investigate the risk for colorectal neoplasia after colonoscopic resection of sessile serrated adenoma/polyps.
Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils
Authors: Christian Wrobel, Alexander Dieter, Antoine Huet, Daniel Keppeler, Carlos J. Duque-Afonso, Christian Vogl, Gerhard Hoch, Marcus Jeschke, Tobias Moser
Journal: Science Translational Medicine (2018)

Virus-mediated expression of channelrhodopsin enables optogenetic stimulation of auditory pathways and restoration of auditory-driven behavior in deaf adult gerbils.
<i>In situ</i> biodistribution and residency of a topical anti‐inflammatory using fluorescence lifetime imaging microscopy
Authors: A. Alex, S. Frey, H. Angelene, C.D. Neitzel, J. Li, A.J. Bower, D.R. Spillman, M. Marjanovic, E.J. Chaney, J.L. Medler, W. Lee, L.S. Vasist Johnson, S.A. Boppart, Z. Arp
Journal: British Journal of Dermatology (2018)

GSK2894512 is a topically delivered investigational drug being developed for treatment of atopic dermatitis and psoriasis.To investigate, in a phase I clinical trial, the spatial biodistribution and residency of GSK2894512 within the epidermis and dermis of healthy human participants noninvasively using fluorescence lifetime imaging microscopy (FLIM).Two topical drug formulations containing GSK2894512 1% were applied to the right and left forearms of six participants for seven consecutive days, followed by seven days of observation for residency. FLIM images were obtained daily throughout the study, approximately every 24 h. During the treatment phase of the study, images were collected from each participant pretreatment, reflecting the residual dose from the previous day. Three punch biopsies from each participant of one formulation was obtained from the treated region during the post-treatment follow-up period between days 8 and 14 for comparison with FLIM results.Cellular and subcellular features associated with different epidermal and dermal layers were visualized noninvasively, down to a depth of 200 μm. Results yielded three-dimensional maps of GSK2894512 spatial distribution and residency over time. This fluorescence data provided a marker that was used as a monitor for day-to-day variance of drug presence and residency postapplication.The results suggest FLIM could be a viable alternative to skin biopsies without the usual patient discomfort and limitations, thereby enabling the direct measurement of skin distribution through longitudinal monitoring. These results are the first step in establishing the unique capabilities that multiphoton imaging could provide to patients through noninvasive drug detection.
ROLE OF EARLY ENDOSCOPIC ULTRASOUND IN IDIOPATHIC ACUTE PANCREATITIS
Authors: M Sharma, P Somani
Journal: Endoscopy (2018)

The cause of acute pancreatitis (AP) remains elusive even after extensive work up in 10 – 30% of cases. The aim of our study was to evaluate the diagnostic yield, feasibility, and management changes of early EUS, performed within 24 – 48 hours of admission in patients with idiopathic acute pancreatitis (IAP).
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
Authors: Lukas Bunse, Stefan Pusch, Theresa Bunse, Felix Sahm, Khwab Sanghvi, Mirco Friedrich, Dalia Alansary, Jana K. Sonner, Edward Green, Katrin Deumelandt, Michael Kilian, Cyril Neftel, Stefanie Uhlig, Tobias Kessler, Anna von Landenberg, Anna S. Berghoff, Kelly Marsh, Mya Steadman, Dongwei Zhu, Brandon Nicolay, Benedikt Wiestler, Michael O. Breckwoldt, Ruslan Al-Ali, Simone Karcher-Bausch, Matthias Bozza, Iris Oezen, Magdalena Kramer, Jochen Meyer, Antje Habel, Jessica Eisel, Gernot Poschet, Michael Weller, Matthias Preusser, Minou Nadji-Ohl, Niklas Thon, Michael C. Burger, Patrick N. Harter, Miriam Ratliff, Richard Harbottle, Axel Benner, Daniel Schrimpf, Jürgen Okun, Christel Herold-Mende, Sevin Turcan, Stefan Kaulfuss, Holger Hess‐Stumpp, Karen Bieback, Daniel P. Cahill, Karl H. Plate, Daniel Hänggi, Marion Dorsch, Mario L. Suvà, Barbara A. Niemeyer, Andreas von Deimling, Wolfgang Wick, Michael Platten
Journal: Nature Medicine (2018)
EUS-GUIDED GASTROENTEROSTOMY (EUS-GE) FOR TREATMENT OF MALIGNAT GASTRIC OUTLET OBSTRUCTION (GOO); FIRST NORWEGIAN EXPERIENCE
Authors: KDC Pham, R Flesland Havre
Journal: Endoscopy (2018)

The treatment for patients with malignant GOO has traditionally been decompression with a nasogastric tube, enteral stenting, and surgical gastroenterostomy. EUS-GE has emerged as a new minimally invasive option, and we present the first series from Norway.
Clarification of the FDA Accelerated Agnostic Approval of Pembrolizumab and the Opportunities Arising From the Required Confirmatory Studies—Reply
Authors: Vinay Prasad, Victoria Kaestner, Sham Mailankody
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Resultados Iniciales de la implantación de la disección endoscópica submucosa en nuestro centro
Authors: PJ Rosón Rodríguez, JM Navarro Jarabo, MA Romero Ordoñez, F Fernandez Cano, E Romero Perez, A Ortega Alonso, C Cano Medel, J Calle Calle, J Cotta Rebollo
Journal: Endoscopy (2017)

Se utilizaron endoscopios Olimpus serie 190, gastroscopio terapéutico para las lesiones gástricas y recto y colonoscopio corto para el resto. La fuente de diatermia ERBE Vio300D. Las lesiones colónica se resecaron con Flush-Knife-BT de 1,5 mm 10 casos y dual Knife-J en dos casos. Se utilizó pinza sumius corta de Sumitomo en tres casos.
High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway
Authors: Elita Yuliantie, Xinchuan Dai, Dehua Yang, Peter J. Crack, Ming-Wei Wang
Journal: Acta Pharmaceutica Sinica B (2018)

Interferons (IFNs) are cytokines with fundamental roles in resistance to infections, cancer and other diseases. Type-I IFNs, interferon α (IFN-α) and interferon β (IFN-β), act through a shared receptor complex (IFNAR) comprised of IFNAR1 and IFNAR2 subunits. Binding of type-I IFN to IFNAR1 will robustly activate Janus activated kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. Aberrant activation of the type-I IFN response results in a spectrum of disorders called interferonopathies. The purpose of this research is to develop an assay for high-throughput screening (HTS) of small molecule inhibitors of the type-I IFN signaling pathway. Inhibition of type-I IFN signaling can be beneficial in terms of therapeutic use and understanding the underlying mechanism of action. We report here a HTS campaign with the secreted embryonic alkaline phosphatase (SEAP) reporter gene assay against 32,000 compounds which yielded 25 confirmed hits. These compounds were subsequently characterized for their cytotoxicity, effects on STAT phosphorylation and activities in IFN regulatory factor (IRF) transcription.
Correlation of High‐Density Lipoprotein–Associated Paraoxonase 1 Activity With Systemic Inflammation, Disease Activity, and Cardiovascular Risk Factors in Psoriatic Disease
Authors: M. Elaine Husni, W. H. Wilson Tang, Michael Lucke, U. M. Chandrasekharan, Danielle M. Brennan, Stanley L. Hazen
Journal: Arthritis & Rheumatology (2018)

To compare the activity of high-density lipoprotein (HDL)-associated paraoxonase 1 (PON1) in patients with psoriasis (PsO) and patients with psoriatic arthritis (PsA), and to evaluate the association of PON1 activity with the extent of disease activity and severity of the cardiovascular disease (CVD) burden in these patients.Serum levels of paraoxonase and arylesterase activity (both measures of PON1 function in humans) were measured in patients with PsA (n = 198, 51.0% male) and patients with PsO (n = 145, 50.3% male) who were enrolled in a longitudinal psoriatic disease biorepository. Data on PsA disease activity (using the Disease Activity Score in 28 joints [DAS28], Clinical Disease Activity Index, and painful/swollen joint counts), preexistent CVD and CVD risk factors (including diabetes, dyslipidemia, hypertension, and smoking), Framingham Risk Scores for CVD, quality of life measures, and laboratory test findings (erythrocyte sedimentation rate, C-reactive protein level, and lipid profiles) were recorded.Serum arylesterase activities were significantly lower in patients with PsO and patients with PsA (mean ± SD 111.1 ± 25.5 μmoles/minute/ml and 124.4 ± 33.4 μmoles/minute/ml, respectively) compared to healthy controls (144.3 ± 33.4 μmoles/minute/ml) (each P < 0.001 versus healthy controls). Serum arylesterase activity decreased in parallel with increasing levels of disease activity (DAS28 scores, P = 0.012), older age (P = 0.013), higher body mass index (P = 0.042), greater incidence of metabolic syndrome (P = 0.004) and hypertension (P = 0.014), and worsening Framingham Risk Scores (P = 0.001). However, no correlation was seen between serum arylesterase activity and the extent of disease activity or CVD burden in patients with PsO. Serum paraoxonase activity trended lower both in patients with PsO and in patients with PsA (each P = 0.073 versus healthy controls). However, no association was seen between serum paraoxonase activity and the extent of disease activity or CVD burden in either of the patient cohorts.PON1 activity is decreased in psoriatic diseases. In the PsA cohort, decreases in arylesterase activity correlated with increasing severity of joint disease and CVD burden. Arylesterase activity, as compared to paraoxonase activity, appeared to serve as a more sensitive predictor of preexisting CV risk factors in the PsA cohort. However, this correlation was not observed in the PsO population.
Abstract 17018: Prognostic Utility of Plasma galectin-3 Level as a Predictor of Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention With Drug-eluting Stents
Authors: Suk Min Seo, Ik Jun Choi, Hun-Jun Park, Pum-Joon Kim, Yoon-Seok Koh, Kiyuk Chang, Jin Jin Kim
Journal: Circulation (2015)

Background: Galectin-3 is associated with inflammation, cell proliferation, and fibrogenesis. It is well known as a novel biomarker on predictor of cardiovascular events in patients with heart failure. However, the prognostic implications of serum galetin-3 level are unknown in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Methods A total 2,568 patients undergoing PCI with DES were consecutively enrolled from January 2004 to December 2009. We can analyzed the serum galectin-3 level of 939 patients, and compared major adverse cardiac events (MACE) including all-cause death, nonfatal myocardial infarction, nonfatal stroke and any revascularization according to galectin-3 level. Results: Median follow up duration was 997 days (interquartile range 766 to 1,264 days). All patients were divided into two groups according to median galectin-3 level (9.52 ng/ml, interquartile range 7.31 to 12.81); high galectin-3 group (n=470) and low galectin-3 group (n=469). High galectin-3 group had significantly higher incidence of all-cause mortality, cardiac death, and composite of MACE. High galectin-3 was a significant independent predictor of MACE (adjusted hazard ratio 1.47, 95% confidence interval 1.13 to 1.92, p=0.005). Conclusion: The higher galectin-3 is associated higher cardiovascular events in patients undergoing PCI with DES. The serum galectin-3 level may serve as a predictor of cardiovascular events after PCI with DES.
Ustekinumab treatment for neutrophilic dermatoses associated with Crohn's disease: A multicenter retrospective study
Authors: Tullia de Risi-Pugliese, Philippe Seksik, Jean-David Bouaziz, François Chasset, Philippe Moguelet, Jean-Marc Gornet, Anne Bourrier, Aurélien Amiot, Laurent Beaugerie, Camille Francès, Sarah Guégan, Benoit Coffin, Benjamin Pariente, Vered Abitbol, Marion Simon, Elise Chantelou
Journal: Journal of the American Academy of Dermatology (2018)
TRANS AORTIC EUS GUIDED FNA IN THE DIAGNOSIS OF LUNG CANCERS AND MEDIASTINAL LYMPH NODES
Authors: M Sharma, P Somani
Journal: Endoscopy (2018)

Obtaining a tissue diagnosis from a lung tumour or a mediastinal lymph node located lateral to the aorta (para-aortal) is a diagnostic challenge because of the interposition of the aorta. Invasive surgical procedures like mediastinotomy, thoracotomy, or video-assisted thoracic surgery is required for the diagnosis of these lesions. Lymph nodes on the “far-side” of major blood vessels can be visualized by EUS, however FNA is avoided due to concern for bleeding complications
Green tea intake, folate pathway genotypes, and breast cancer risk: the Singapore Chinese Health Study
Authors: Maki Inoue, Kim Robien, Renwei Wang, David van den Berg, Woon-Puay Koh, Mimi Yu
Journal: Cancer Research (2008)

1924   Green tea and its major component (-)-epigallocatechin gallate (EGCG) have been extensively studied for potential cancer preventive effects. Experimental studies have shown that EGCG may have antifolate activities and competitively inhibit the conversion of dihydrofolate to tetrahydrofolate. We hypothesized that if folate cycle inhibition is the mechanism for cancer preventive effects of EGCG, then the green tea effect on breast cancer risk would be stronger among women with low (below median level for the whole female cohort) vs. high folate intake and high- (sum of variant alleles is either zero or one) vs. low enzyme activity genotypes of methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS), key regulatory enzymes in folate metabolism. We conducted a nested case-control study of breast cancer within the Singapore Chinese Health Study, a population-based prospective cohort study of over 63,000 men and women, aged 45-74 years, enrolled during 1993-1998. The analysis involved 381 incident cases of breast cancer and 663 control women. We used logistic regression methods to examine the tea/folate/genotype associations with breast cancer, with adjustment for age at study enrollment, year of study enrollment, dialect group, level of education, body mass index, age when period became regular, number of live births, and black tea intake. Overall, there was no association between either green tea intake or MTHFR/TYMS genotypes and breast cancer risk. However, among women with low folate intake, weekly/daily vs. less frequent green tea intake was significantly associated with reduced breast cancer risk (odds ratio (OR)=0.45, 95% confidential interval (CI)=0.26-0.79). The comparable OR (95%CI) among women with high folate intake was 1.04 (0.72-1.51) (2-sided p for interaction=0.02). Similarly, among women possessing the high enzyme activity MTHFR/TYMS genotypes, weekly/daily vs. less frequent green tea intake was associated with a statistically significant decrease in breast cancer risk (OR=0.66, 95%CI=0.45-0.98), which, consistent with other reports, was even stronger among those who also had low dietary folate intake (OR=0.44, 95% CI=0.22-0.89 vs. high dietary folate: OR=0.92, 95% CI=0.55-1.54). No statistically significant associations between weekly/daily vs. less frequent green tea intake and breast cancer risk were observed among women possessing the low enzyme activity MTHFR/TYMS genotypes, or when further stratified by dietary folate intake. Results were similar when folate intake was included as a covariate in the logistic regression model rather than as a stratifying variable. To our knowledge, this is the first epidemiologic report of folate-EGCG interaction in carcinogenesis. Our findings suggest that folate cycle inhibition may be one mechanism through which green tea protects against breast cancer in humans.
PROTON PUMP INHIBITOR-RESPONSIVE ESOPHAGEAL EOSINOPHILIA: AN OVERVIEW OF CASES FROM ONE UNIVERSITY HOSPITAL CENTER IN KOREA
Authors: DH Lee
Journal: Endoscopy (2018)

Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease, with eosinophilic infiltration limited to the esophagus. A minority of EoE patients respond well to proton pump inhibitor (PPI) therapy alone, and that condition is labelled PPI-responsive esophageal eosinophilia (PPI-REE). The prevalence of PPI-REE among EoE cases is unknown. We aimed to identify clinical manifestations of PPI-REE, and the proportion of PPI-REE among all EoE cases.