tbuckley/cabot-search huggingface dataset:
Preclinical assessment of an antibody–PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells
Authors: Krista Kinneer, Matt Flynn, Suneetha B. Thomas, John Meekin, Reena Varkey, Xiaodong Xiao, Haihong Zhong, Shannon Breen, Paul G. Hynes, Ryan Fleming, Binyam Bezabeh, Cui (Tracy) Chen, Leslie Wetzel, Ruoyan Chen, Nazzareno Dimasi, Yu-Tzu Tai, Kenneth C. Anderson, Ronald Herbst, Philip W. Howard, Elaine M. Hurt, David A. Tice
Journal: Leukemia (2018)
Induction chemotherapy plus chemoradiotherapy with or without aspirin in high risk rectal cancer (ICAR)
Authors: J.C.E.S.O.D. Souza, R. Araujo, M. Valadão, C. Carrara, M.Á Barbosa, R. Guimarães, J. Carvalho, G. Kovaleski, I. Small, A. Marins, A.P. Victorino, R. Gil, J.P. Jesus, L.H. de Araujo, A.C. de Melo
Journal: Annals of Oncology (2018)
Should Aspirin Be Used for Primary Prevention in the Post-Statin Era?
Authors: Paul M Ridker
Journal: New England Journal of Medicine (2018)

Between 1853 and 1897, German chemists learned to efficiently combine sodium salicylate with acetyl chloride to produce acetylsalicylic acid. That compound, trademarked as aspirin, proved to be a remarkable antiinflammatory and antithrombotic agent and one of the most widely used drugs in pharmaceutical history. As the medical community's understanding of platelet biology and atherothrombosis evolved, it became clear that aspirin was highly effective in the secondary prevention of cardiovascular events. Subsequent large-scale primary prevention trials, including the Physicians' Health Study and the Women's Health Study, provided evidence of small-to-modest cardiovascular benefits in high-risk patients, albeit with an increased risk of . . .
Inappropriate Use of Fecal Occult Blood Testing
Authors: Saroja Bangaru, David Tang, Deepak Agrawal
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 20653: A Novel Protein, Early Secreted Antigenic Target of 6 kDa, Promotes Cardiac Allograft Tolerance by Inducing CD4+FoxP3+ Tregs
Authors: Zhenhua Dai, Qi Li, Hehua Dai
Journal: Circulation (2014)

Introduction: Cardiac transplant provides a cure for end-stage heart diseases. However, a cardiac allograft is always rejected by recipients without immunosuppression (IS). Inducing transplant tole...
Coverings avoid frostbites and do not reduce efficacy of cryotherapy for prevention of chemotherapy-induced neuropathy
Authors: Akiko Hanai, Hiroshi Ishiguro, Takashi Sozu, Moe Tsuda, Ikuko Yano, Takayuki Nakagawa, Satoshi Imai, Yoko Hamabe, Masakazu Toi, Hidenori Arai, Tadao Tsuboyama
Journal: Annals of Oncology (2018)
Microbiological and clinical characteristics of Acinetobacter baumannii bacteremia: Implications of sequence type for prognosis
Authors: Yu-Chung Chuang, Aristine Cheng, Hsin-Yun Sun, Jann-Tay Wang, Yee-Chun Chen, Wang-Huei Sheng, Shan-Chwen Chang
Journal: Journal of Infection (2018)
Review: In trigeminal neuralgia, carbamazepine, botulinum toxin type A, or lidocaine improve response rate vs placebo
Authors: Daniel I. Steinberg
Journal: Annals of Internal Medicine (2018)

ACP Journal Club16 October 2018Review: In trigeminal neuralgia, carbamazepine, botulinum toxin type A, or lidocaine improve response rate vs placeboDaniel I. Steinberg, MDDaniel I. Steinberg, MDIcahn School of Medicine at Mount Sinai, New York City, New York, USA (D.I.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2018-169-8-043 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationYang F, Lin Q, Dong L, Gao X, Zhang S. Efficacy of 8 different drug treatments for patients with trigeminal neuralgia: a network meta-analysis. Clin J Pain. 2018;34:685-90. https://pubmed.ncbi.nlm.nih.gov/29200017Clinical Impact RatingsGIM/FP/GP: Geriatrics: Neurology: References1 Gronseth G, Cruccu G, Alksne J, et al. Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies. Neurology. 2008;71:1183-90. [PMID: 18716236] Google Scholar2 Wiffen PJ, Derry S, Moore RA, Kalso EA. Carbamazepine for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2014;4:CD005451. [PMID: 24719027] Google Scholar3 Niki Y, Kanai A, Hoshi K, Okamoto H. Immediate analgesic effect of 8% lidocaine applied to the oral mucosa in patients with trigeminal neuralgia. Pain Med. 2014;15:826-31. [PMID: 24506194] Google Scholar4 Wu CJ, Lian YJ, Zheng YK, et al. Botulinum toxin type A for the treatment of trigeminal neuralgia: results from a randomized, double-blind, placebo-controlled trial. Cephalalgia. 2012;32:443-50. [PMID: 22492424] Google Scholar5 Zhang H, Lian Y, Ma Y, et al. Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlled trial. J Headache Pain. 2014;15:65. [PMID: 25263254] Google Scholar Author, Article, and Disclosure InformationAffiliations: Icahn School of Medicine at Mount Sinai, New York City, New York, USA (D.I.S.)This article was published at Annals.org on 2 October 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 October 2018Volume 169, Issue 8Page: JC43KeywordsBotulinum toxinDrugsNetwork analysisNeurologyNeuropathic painNumber needed to harmOdds ratioPatientsSystematic reviewsTreatment guidelines ePublished: 16 October 2018 Issue Published: 16 October 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non–Small Cell Lung Cancer
Authors: Charu Aggarwal, Jeffrey C. Thompson, Taylor A. Black, Sharyn I. Katz, Ryan Fan, Stephanie S. Yee, Austin L. Chien, Tracey L. Evans, Joshua M. Bauml, Evan W. Alley, Christine A. Ciunci, Abigail T. Berman, Roger B. Cohen, David B. Lieberman, Krishna S. Majmundar, Samantha L. Savitch, Jennifer J. D. Morrissette, Wei-Ting Hwang, Kojo S. J. Elenitoba-Johnson, Corey J. Langer, Erica L. Carpenter
Journal: JAMA Oncology (2018)

The clinical implications of adding plasma-based circulating tumor DNA next-generation sequencing (NGS) to tissue NGS for targetable mutation detection in non-small cell lung cancer (NSCLC) have not been formally assessed.To determine whether plasma NGS testing was associated with improved mutation detection and enhanced delivery of personalized therapy in a real-world clinical setting.This prospective cohort study enrolled 323 patients with metastatic NSCLC who had plasma testing ordered as part of routine clinical management. Plasma NGS was performed using a 73-gene commercial platform. Patients were enrolled at the Hospital of the University of Pennsylvania from April 1, 2016, through January 2, 2018. The database was locked for follow-up and analyses on January 2, 2018, with a median follow-up of 7 months (range, 1-21 months).The number of patients with targetable alterations detected with plasma and tissue NGS; the association between the allele fractions (AFs) of mutations detected in tissue and plasma; and the association of response rate with the plasma AF of the targeted mutations.Among the 323 patients with NSCLC (60.1% female; median age, 65 years [range, 33-93 years]), therapeutically targetable mutations were detected in EGFR, ALK, MET, BRCA1, ROS1, RET, ERBB2, or BRAF for 113 (35.0%) overall. Ninety-four patients (29.1%) had plasma testing only at the discretion of the treating physician or patient preference. Among the 94 patients with plasma testing alone, 31 (33.0%) had a therapeutically targetable mutation detected, thus obviating the need for an invasive biopsy. Among the remaining 229 patients who had concurrent plasma and tissue NGS or were unable to have tissue NGS, a therapeutically targetable mutation was detected in tissue alone for 47 patients (20.5%), whereas the addition of plasma testing increased this number to 82 (35.8%). Thirty-six of 42 patients (85.7%) who received a targeted therapy based on the plasma result achieved a complete or a partial response or stable disease. The plasma-based targeted mutation AF had no correlation with depth of Response Evaluation Criteria in Solid Tumors response (r = -0.121; P = .45).Integration of plasma NGS testing into the routine management of stage IV NSCLC demonstrates a marked increase of the detection of therapeutically targetable mutations and improved delivery of molecularly guided therapy.
Abstract 19246: Histology-Validated Neural Networks Enable Accurate Plaque Tissue and Thin-Capped Fibroatheroma Characterization Through Intravascular Optical Coherence Tomography
Authors: Vikram L Baruah, Aydin Zahedivash, Taylor B Hoyt, Deborah Vela, L. Maximilian Buja, Thomas E Milner, Marc D Feldman
Journal: Circulation (2016)

Introduction: Although intravascular ultrasound can successfully classify plaque composition in an automated fashion through ultrasound virtual histology, this has not been accomplished with intravascular optical coherence tomography (IVOCT). The complexity of IVOCT images has limited its clinical acceptance despite its greater resolution. This is particularly true with thin-capped fibroatheroma (TCFA), which are uniquely recognized by IVOCT, but prone to be falsely identified by expert viewers. Hypothesis: We assessed the hypothesis that histology validated supervised neural networks can reliably characterize arterial tissue and TCFA in IVOCT images. Methods: Neural network features and nodes were optimized to best classify arterial fibrous, calcium and lipid tissue in IVOCT images. Grey level co-occurrence matrix and windowed texture analysis was used to develop network features. Lipid pixels were used to isolate TCFA. The network was trained on 81000 pixels and tested on 61000 pixels, sampled separatel...
Abstract 20832: Neutrophil Extracellular Traps Increase Endothelial Activation and Thrombogenicity via IL-1α and NF-κB: Implications for Superficial Erosion
Authors: Thomas Mawson, Eduardo Folco, Gregory Franck, Amelie Vromman, Breno Bernardes de Souza, Oscar Persson, Eugenia Shvartz, Peter Libby
Journal: Circulation (2017)

Introduction: Coronary artery thrombosis can occur in the absence of plaque rupture due to superficial erosion. Erosion-prone atheromata associate with more neutrophil extracellular traps (NETs) th...
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration
Authors: Jae Kyu Ryu, Victoria A. Rafalski, Anke Meyer-Franke, Ryan A. Adams, Suresh B. Poda, Pamela E. Rios Coronado, Lars Østergaard Pedersen, Veena Menon, Kim M. Baeten, Shoana L. Sikorski, Catherine Bedard, Kristina Hanspers, Sophia Bardehle, Andrew S. Mendiola, Dimitrios Davalos, Michael R. Machado, Justin P. Chan, Ioanna Plastira, Mark A. Petersen, Samuel J. Pfaff, Kenny K. Ang, Kenneth K. Hallenbeck, Catriona Syme, Hiroyuki Hakozaki, Mark H. Ellisman, Raymond A. Swanson, Scott S. Zamvil, Michelle R. Arkin, Stevin H. Zorn, Alexander R. Pico, Lennart Mucke, Stephen B. Freedman, Jeffrey B. Stavenhagen, Robert B. Nelson, Katerina Akassoglou
Journal: Nature Immunology (2018)
UCGI 28 Panirinox: A randomized phase II study assessing Panitumumab + FOLFIRINOX or mFOLFOX6 in RAS and BRAF wild type metastatic colorectal cancer patients (mCRC) selected from circulating DNA analysis
Authors: T. Mazard, F. Ghiringhelli, C. Mollevi, E. Assenat, C. Gavoille, D. Smith, V. Pezzella, R. Meddeb, B. Pastor, M. Ychou, A.R. Thierry
Journal: Annals of Oncology (2018)
Serious illness often means financial disaster for Americans, study finds
Authors: Janice Hopkins Tanne
Journal: BMJ (2018)

More than half of Americans who become seriously ill face financial ruin despite most having health insurance. About 1.6 million people have declared bankruptcy in recent years, says a national survey by the Commonwealth Fund, the New York Times , and Harvard University’s T H Chan School of Public Health.12

“Americans spend more than citizens of any other country with the hope that the right care will be there for them when serious illness strikes,” the report says. But during their care they experience helplessness, confusion, problems getting treatment, and severe financial burdens.

The survey looked at the financial and emotional effects of serious illness in a nationally representative sample of 1495 adults. They either had an illness such as heart disease, cancer, diabetes, or stroke and had been …
Silk Fibroin Microparticles with Hollow Mesoporous Silica Nanocarriers Encapsulation for Abdominal Wall Repair
Authors: Xin Zhao, Zhuoyue Chen, Yuxiao Liu, Qian Huang, Huidan Zhang, Wu Ji, Jianan Ren, Jieshou Li, Yuanjin Zhao
Journal: Advanced Healthcare Materials (2018)

Abstract Therapeutic vascularization appears to be an effective way of repairing abdominal wall defects. Attempts to implement this treatment tend to focus on the generation of featured drug carriers with the ability effectively to encapsulate the angiogenesis‐stimulating agents and control their release to maintain an appropriate concentration at the injured area. Here, a new type of composite microparticle (CM) composed of silk fibroin (SF) and hollow mesoporous silica nanocarriers (HMSNs) is presented for therapeutic agent delivery. The CMs are generated by drying microfluidic emulsion templates of HMSN‐dispersed SF solution. The resultant CMs have a distinctive micro‐nanostructure, in which two barriers control the drug release. The encapsulated HMSNs increase the drug‐carrying capacity of the CMs, and also form the first barrier via physical absorption. The microfluidic SF microparticles not only provide a shell with excellent monodispersity and biocompatibility but also form the second barrier via efficient encapsulation. Because of these superior properties of the CMs, the loaded drugs can be delivered with a satisfactory activity at the required rate, making them ideal for implementing therapeutic vascularization and repairing abdominal wall defects.
A genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients
Authors: F. Innocenti, C. Jiang, A.B. Sibley, S. Denning, A.S. Etheridge, D. Watson, D. Niedzwiecki, A.J. Hatch, H. Hurwitz, A. Nixon, Y. Furukawa, M. Kubo, D.J. Crona, H. Kindler, H.L. McLeod, M.J. Ratain, K. Owzar
Journal: Annals of Oncology (2018)
The E2F1–miR-520/372/373–SPOP Axis Modulates Progression of Renal Carcinoma
Authors: Meng Ding, Xiaolan Lu, Cheng Wang, Quan Zhao, Jingping Ge, Qiuyuan Xia, Junjun Wang, Ke Zen, Chen-Yu Zhang, Chunni Zhang
Journal: Cancer Research (2018)

Abstract Although renal cell carcinoma (RCC) is the most malignant urologic cancer, its pathogenesis remains unclear, and effective treatments for advanced RCC are still lacking. Here, we report that a novel E2F1–miR-520/372/373–SPOP axis controls RCC carcinogenesis. Speckle-type POZ protein (SPOP) was upregulated in over 90% of RCC tissues, whereas the miR-520/372/373 family was downregulated and correlated inversely with SPOP protein levels in RCC tissues. The miR-520/372/373 family targeted the SPOP 3′-UTR and suppressed SPOP protein expression, leading to elevation of PTEN and DUSP7 levels and, consequently, decreased proliferation, invasion/migration, and metastasis of RCC cells in vitro and in vivo. Tail-vein delivery of therapeutic miR-520/372/373 family significantly decreased both tumor size and lung metastasis ratio in mice bearing orthotopic xenograft tumors. Decreased expression of miR-520/372/373 family was mediated by transcription factor E2F1. In conclusion, our results demonstrate that the E2F1-miR-520/372/373–SPOP axis functions as a key signaling pathway in RCC progression and metastasis and represents a promising opportunity for targeted therapies. Significance: These findings show that the E2F1-miR-520/372/373 family–SPOP axis promotes RCC progression, thereby contributing to our understanding of RCC pathogenesis and unveiling new avenues for more effective targeted therapies.
GW29-e0950 Effect of Glucocorticoid on the Circulating Renin-Angiotensin-Aldosterone System in Heart Failure
Authors: Chao Liu, ShiJia Wang, Xiaoran Zhu, Haifang Ma, Yu Wang, Yuzhi Zhen, Qingzhen Zhao, Dan Wu, Chao Liu
Journal: Journal of the American College of Cardiology (2018)
Abstract 14964: Radiotherapy Doses ≥ 50 Gray Correlate With Carotid Artery Volume Loss on Comparison of Pre- and Post-Radiotherapy CTs
Authors: Salman A Eraj, Mona K Jomaa, Andrea Jarre, Aasheesh Kanwar, Jay C Shiao, Subha Perni, Elie Mouhayar, Abdallah S Mohamed, David I Rosenthal, Clifton D Fuller
Journal: Circulation (2017)

Hypothesis: Volumetric changes in the carotid arteries after unilateral radiation for early tonsillar cancer will differ between the irradiated and untreated control sides. Methods: Disease-free ca...
Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities
Authors: Aleksandra Deczkowska, Michal Schwartz
Journal: The Journal of Experimental Medicine (2018)

Immune cells patrol the brain and can support its function, but can we modulate brain-immune communication to fight neurological diseases? Here, we briefly discuss the mechanisms orchestrating the cross-talk between the brain and the immune system and describe how targeting this interaction in a well-controlled manner could be developed as a universal therapeutic approach to treat neurodegeneration.
Circumferential esophageal endoscopic submucosal dissection thanks to the tunnel + clip strategy: four tunnels to facilitate the procedure
Authors: Marion Schaefer, Jérémie Albouys, Aurélie Charissoux, Denis Sautereau, Romain Legros, Mathieu Pioche, Jérémie Jacques
Journal: Endoscopy (2018)

A 66-year-old man was referred to our endoscopy unit for endoscopic submucosal dissection (ESD) of a superficial circumferential adenocarcinoma developing over by severe Barrett's esophagus.
Abstract 13292: Bradycardia as a Manifestation of Chikungunya Myocarditis. A New Threat to America
Authors: Karina A Gonzalez Carta, Ivan J Mendoza_Britto, Vicente Finizola, Igor Morr, Jaime Torres, Yolimar Meza, Juan Marquez, Iris Villalobos, Rosalyn Vasquez, Gerardo Chazzim, Claudia Morr, Carlos Morr, Ivan J Mendoza
Journal: Circulation (2016)

Background: Chikungunya fever is an arthropod-borne disease that has caused millions of infections globally. Local transmission has been reported in the United States. There are very few published reports concerning the cardiac complications in general and bradycardia in particular. Objective: To investigate the occurrence of myocarditis and bradycardia in patients with Chikungunya fever. Methods: Prospective multicenter observational studio of 287 patients with a chikungunya infection during a Venezuelan outbreak. Clinical evaluation, X Ray, ECG, Echocardiogram, Holter, laboratory including virological evaluation, cardiac biomarkers, and cardiac MRI procedures were performed. Results: Of the 287 patients examined, 117 were male with a mean age of 59 ± 8; 277 patients presented with fever and polyarthralgia and 91 developed palpitations. Arrhythmias occurred in 45% of cases; they included bradiarrhytmias (33%), atrial and ventricular ectopic beats and tachyarrhythmia’s in which atrial fibrillation was observed in 19 cases. There were also ectopic atrial tachycardia and non-sustained ventricular tachycardia, conduction disturbances and 3 cases of sudden death. Conclusion: Physicians should be aware of the possibility of manifest or silent myocarditis in almost half of patients with Chikungunya disease. In a proper epidemiological context, the triad of fever, polyarthralgia and new arrhythmia, including bradiarrhytmias suggests Chikungunya myocarditis.
A revised international prognostic score system for Waldenström’s macroglobulinemia
Authors: M. Gavriatopoulou, E. Kastritis, P. Morel, A. Duhamel, M.C. Kyrtsonis, E. Durot, A. Symeonidis, K. Laribi, E. Hatjiharisi, L. Ysebaert, A. Vassou, N. Giannakoulas, G. Merlini, P. Repousis, M. Varettoni, E. Michalis, B. Hivert, M. Michalis, V. Leblond, M.A.C. Dimopoulos
Journal: Annals of Oncology (2018)
GW29-e0413 The effect of Shen-Yuan-Dan Capsule on autophagy gene Atg13 promoter methylation and PI3K/Akt/mTORC1 signaling pathway in atherosclerotic mice
Authors: Mingxue Zhou, Zhibao Li, Mingxue Zhou, Sinai Li, Pan Ren, Qunfu Kang, Ping Li, Lei Zhang, Juju Shang, Weihong Liu, Hongxu Liu
Journal: Journal of the American College of Cardiology (2018)
Gene expression profiling of hepatocellular cancer identifies a consistent pattern in cancerous and distant liver tissue: Arguments for a field defect
Authors: George Zogopoulos, Limin Chen, Ivan Borozan, Jing Sun, Jenny Heathcote, Steven Gallinger, Aled Edwards, Ian McGilvray
Journal: Cancer Research (2005)

6099   The genetic changes that accompany hepatocellular cancer (HCC) are notoriously variable, though the cancer itself may develop in the context of an organ-wide field defect. We hypothesized that the pattern of gene expression reflecting such a field defect would persist in the HCC itself, and would be distinct from patterns of liver gene expression in chronic liver disease patients who have not developed HCC. Using a 19K human microarray, we determined gene expression levels in 15 HCC samples and 15 liver samples taken at least 5 cm away from the original HCC (distant liver tissue, DLT). These were compared to liver biopsies from patients with chronic liver disease but no HCC (86 HCV biopsies, 18 HBV biopsies). All gene expression changes were normalized to the baseline level of gene expression in 20 normal liver biopsies. Insisting on a high statistical filter (p
Abstract 15523: Biomarkers Predict Cause of Death More Accurately Than Clinical Variables in Patients With Atrial Fibrillation on Oral Anticoagulation - Results From the ARISTOTLE Trial
Authors: Ziad Hijazi, Abhinav Sharma, Ulrika Andersson, John H Alexander, Sana M Al-Khatib, Michael Hanna, Claes Held, Elaine M Hylek, Renato D Lopes, Agneta Siegbahn, Christopher B Granger, Lars Wallentin
Journal: Circulation (2016)

Introduction: Mortality is the most frequent adverse outcome in anticoagulated patients with atrial fibrillation (AF). Several cardiac biomarkers are associated with increased mortality, but the as...
An open-label, non-randomized, phase IIIb study of trametinib in combination with dabrafenib for patients with unresectable (stage III) or distant metastatic (stage IV) BRAF V600-mutant melanoma
Authors: P. Saiag, C. Robert, J.J. Grob, L. Mortier, O. Dereure, C. Lebbe, S. Mansard, F. Grange, E.-M. Neidhardt, T. Lesimple, L. Machet, C. Bedane, G. Jeudy, F. Aubin, B. Dreno, A. Szenik, A. Denden, C. Dutriaux
Journal: Annals of Oncology (2018)