tbuckley/cabot-search huggingface dataset:
Resistenza batterica agli antibiotici in Francia: una priorità di sanità pubblica
Authors: H Aubry Damon, J Carlet, P Courvalin, J C Desenclos, J Drucker, D Guillemot, V Jarlier, B Régnier, B Schlemmer
Journal: Eurosurveillance (2000)

Da alcuni anni si assiste in Francia a una rapida diffusione della resistenza agli antibiotici sia in caso di infezioni ospedaliere sia per quelle acquisite in comunita, nonostante le molte raccomandazioni miranti a risolvere questo problema. Nel 1999, per iniziativa dell'Institut de Veille Sanitaire, e stata organizzata una expertise collettiva a livello nazionale, seguita dalla consulenza di vari gruppi di operatori sanitari coinvolti nel settore. Questa consulenza ha portato a delle proposte orientate alla creazione di un piano nazionale di misure di controllo della resistenza antimicrobica, presentate al Ministero della Sanita francese.
Gene expression signatures in BRAF V600E mutant colorectal cancer in relation to WNT signaling cascade
Authors: K. Yasui, T. Nagasaka, A. Nyuya, T. Toshima, T. Kawai, K. Shigeyasu, S. Yano, Y. Mori, J. Haraga, K. Nakamura, Y. Umeda, A. Goel, T. Fujiwara
Journal: Annals of Oncology (2017)
GW28-e0701 Dipeptidyl peptidase 4 inhibitor attenuates obesity-induced myocardial fibrosis by inhibiting tissue growth factor-beta and Smad2/3 pathways in high-fat diet-induced obesity rat model
Authors: Sang-Hyun Ihm, Seul Ki Hong, Kiyuk Chang
Journal: Journal of the American College of Cardiology (2017)
Osimertinib in Asia-Pacific patients (pts) with EGFR T790M-positive advanced NSCLC: Updated Phase II study results including progression-free survival (PFS)
Authors: C. Zhou, M. Wang, Y. Cheng, Y. Chen, Y. Zhao, Y-K. Shi, M-J. Ahn, Y. Chen, X. Huang, M. Cantarini, Y-L. Wu
Journal: Annals of Oncology (2017)
HSP27 - a novel target for non-small cell lung cancer affecting tumor growth and motility.
Authors: Tanguy Seiwert, Palma Rocchi, Lynn Bracht, Varalakshmi Janamanchi, Ramasamy Jagadeeswaran, Aliya Husain, Dongfeng Tan, Li Qiang, Martin Gleave, Ravi Salgia
Journal: Cancer Research (2007)

1343   Purpose: To determine the role of HSP27 in non-small cell lung cancer (NSCLC) in tumor samples (expression), and in in-vitro and in-vivo models (overexpression/ suppression).  Methods: Tumor tissue microarrays (TMA) were stained for HSP27 and Phospho-HSP27 (IHC) and results correlated with outcome. Expression in metastases was compared with the respective matched primary tumors. HSP27 was overexpressed using lentivirus transfected A549 cells and compared with control sequence transfected A549. Cells were studied a) in-vivo for tumor growth, b) in-vitro for motility by time lapse microscopy. HSP27 was suppressed with specific siRNA (in-vitro) and HSP27 antisense (OGX-427; in-vitro and in-vivo). Normal human bronchial epithelial cells (NHBE) were used as controls (in-vitro). Cell cycle analysis was performed. Wortmannin and LY290042 were used to inhibit PI3K.  Results: HSP27/ Phospo-HSP27 were overexpressed in 65%/ 61% of tumor tissues. HSP27 expression was significantly higher in matched metastases in comparison to primary tumors (p  Conclusions: HSP27 is a promising novel target in NSCLC with a role in tumor growth and motility. HSP27 induced cell motility is PI3K dependent. Increased expression in metastases suggests a role of HSP27 in the metastatic process in patients. HSP27 inhibition is feasible both in-vitro and in-vivo and leads to a marked decreased in tumor growth, induction of apoptosis, and abrogation of cell motility/ membrane ruffling. OGX-427 (HSP27 antisense) is promising for further studies and clinical development in NSCLC.
Effects of Febuxostat in Early Gout
Authors: Nicola Dalbeth, Kenneth G. Saag, William E. Palmer, Hyon K. Choi, Barbara Hunt, Patricia A. MacDonald, Ulrich Thienel, Lhanoo Gunawardhana
Journal: Arthritis & Rheumatology (2017)

To assess the effect of treatment with febuxostat versus placebo on joint damage in hyperuricemic subjects with early gout (1 or 2 gout flares).In this double-blind, placebo-controlled study, 314 subjects with hyperuricemia (serum uric acid [UA] level of ≥7.0 mg/dl) and early gout were randomized 1:1 to receive once-daily febuxostat 40 mg (increased to 80 mg if the serum UA level was ≥6.0 mg/dl on day 14) or placebo. The primary efficacy end point was the mean change from baseline to month 24 in the modified Sharp/van der Heijde erosion score for the single affected joint. Additional efficacy end points included change from baseline to month 24 in the Rheumatoid Arthritis Magnetic Resonance Imaging Scoring (RAMRIS) scores for synovitis, erosion, and edema in the single affected joint, the incidence of gout flares, and serum UA levels. Safety was assessed throughout the study.Treatment with febuxostat did not lead to any notable changes in joint erosion over 2 years. In both treatment groups, the mean change from baseline to month 24 in the modified Sharp/van der Heijde erosion score for the single affected joint was minimal, with no between-group differences. However, treatment with febuxostat significantly improved the RAMRIS synovitis score at month 24 compared with placebo treatment (change from baseline -0.43 versus -0.07; P <0.001), decreased the overall incidence of gout flares (29.3% versus 41.4%; P < 0.05), and improved serum UA control (62.8% versus 5.7%; P < 0.001). No major safety concerns were reported.Urate-lowering therapy with febuxostat improved magnetic resonance imaging-determined synovitis and reduced the incidence of gout flares in subjects with early gout.
Prognostic estimates of Ki-67 percentage drop after neoadjuvant chemotherapy (NAC) in luminal B (lumB) and triple negative breast cancer (TNBC)
Authors: J. Pascual, B. Rojas-Garcia, V. Peg, S. Diaz-Botero, E. Zamora, E. Muñoz Couselo, M. Oliveira, P. Gomez Pardo, J. Perez Garcia, F. Ruiz-Pace, C. Viaplana, S. Escrivá, L. Garrigos, M. Arumi, M. Espinosa-Bravo, J. Cortés, I. Rubio, C. Saura, R. Dienstmann, M. Bellet Ezquerra
Journal: Annals of Oncology (2017)
Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis
Authors: Virginia Byers Kraus, Jamie E. Collins, H. Cecil Charles, Carl F. Pieper, Lawrence Whitley, Elena Losina, Michael Nevitt, Steve Hoffmann, Frank Roemer, Ali Guermazi, David J. Hunter
Journal: Arthritis & Rheumatology (2017)

Objective To evaluate radiographic subchondral trabecular bone texture ( TBT ) as a predictor of clinically relevant osteoarthritis ( OA ) progression (combination of symptom and structural worsening). Methods The Foundation for the National Institutes of Health ( FNIH ) OA Biomarkers Consortium undertook a study of progressive knee OA cases (n = 194 knees with both radiographic and pain progression over 24–48 months) and comparators (n = 406 OA knees not meeting the case definition). TBT parameters were extracted from a medial subchondral tibial region of interest by fractal signature analysis of radiographs using validated semiautomated software. Baseline TBT and time‐integrated values over 12 and 24 months were evaluated for association with case status and separately with radiographic and pain progression status, adjusted for age, sex, body mass index, race, baseline Kellgren/Lawrence grade, baseline joint space width, Western Ontario and McMaster Universities Osteoarthritis Index pain score, and pain medication use. C statistics were generated from receiver operating characteristic curves. Results Relative to comparators, cases were characterized by thinner vertical and thicker horizontal trabeculae. The summed composite of 3 TBT parameters at baseline and over 12 and 24 months best predicted case status (odds ratios 1.24–1.43). The C statistic for predicting case status using the TBT composite score (0.633–0.649) was improved modestly but statistically significantly over the use of covariates alone (0.608). One TBT parameter, reflecting thickened horizontal trabeculae in cases, at baseline and over 12 and 24 months, predicted risk of any progression (radiographic and/or pain progression). Conclusion Although associations are modest, TBT could be an attractive means of enriching OA trials for progressors since it can be generated from screening knee radiographs already standard in knee OA clinical trials.
Cytomegalovirus in Patients in the Intensive Care Unit—Reply
Authors: Nicholas J. Cowley, Paul Moss, Julian F. Bion
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Clinical practice observation of trastuzumab (TRA) in patients (pts) with HER2-positive metastatic adenocarcinoma of the stomach (mGC) or the gastro-oesophageal junction (GEJ): Final analysis from the German non-interventional study HerMES
Authors: S-E. Al-Batran, E. Moorahrend, C. Maintz, D. Hempel, P. Thuss-Patience, V. Gaillard, S. Hegewisch Becker
Journal: Annals of Oncology (2017)
GW28-e1201 Macrophage migration inhibitory factor promotes cardiac fibroblast proliferation through Src kinase signaling pathway
Authors: Xue Yu-mei, Deng Chun-yu, Wei Wei, Liu Fang-zhou, Yang Hui, Li Xin, Wang Zhao-yu, Kuang Su-juan, Wu Shu-lin, Rao Fang
Journal: Journal of the American College of Cardiology (2017)
Ribosome Profiling Reveals Genome-Wide Cellular Translational Regulation Upon Heat Stress in <i>Escherichia Coli</i>
Authors: Yanqing Zhang, Zhengtao Xiao, Qin Zou, Jianhuo Fang, Qifan Wang, Xuerui Yang, Ning Gao
Journal: Genomics Proteomics & Bioinformatics (2017)

Abstract Heat shock response is a classical stress-induced regulatory system in bacteria, characterized by extensive transcriptional reprogramming. To compare the impact of heat stress on the transcriptome and translatome in Escherichia coli, we conducted ribosome profiling in parallel with RNA-Seq to investigate the alterations in transcription and translation efficiency when E. coli cells were exposed to a mild heat stress (from 30 °C to 45 °C). While general changes in ribosome footprints correlate with the changes of mRNA transcripts upon heat stress, a number of genes show differential changes at the transcription and translation levels. Translation efficiency of a few genes that are related to environment stimulus response is up-regulated, and in contrast, some genes functioning in mRNA translation and amino acid biosynthesis are down-regulated at the translation level in response to heat stress. Moreover, our ribosome occupancy data suggest that in general ribosomes accumulate remarkably in the starting regions of ORFs upon heat stress. This study provides additional insights into bacterial gene expression in response to heat stress, and suggests the presence of stress-induced but yet-to-be characterized cellular regulatory mechanisms of gene expression at translation level.
Are inhaled corticosteroids increasing the “load” for some patients with COPD?
Authors: Tom M.A. Wilkinson
Journal: European Respiratory Journal (2017)

The clinical burden of chronic obstructive pulmonary disease (COPD) remains one of the most significant unmet needs not only in respiratory medicine but in global health [1, 2]. Despite drives to improve diagnosis rates, encourage smoking cessation and improve function with pulmonary rehabilitation and prescription of inhaled therapies, impacts on quality of life and healthcare resources continue to place an unacceptable load on both patients and health services [1]. A key driver for this health burden is acute exacerbations, which continue to affect a patient's health even after optimal medical management is in place [1]. Inhaled corticosteroids cause increases in sputum bacterial load in COPD patients with lower eosinophil levels <http://ow.ly/kCcS30feTru>
Salmonella enteritidis et Salmonella typhimurium en Europe de l’ouest de 1993 à 1995 : un rapport de surveillance de Salm-Net
Authors: I. S.T. Fisher
Journal: Eurosurveillance (1997)

La surveillance a ete definie comme «la collecte, l’analyse, et la distribution reguliere et rapide de l’information a ceux qui en ont besoin, pour permettre le declenchement d’actions adaptees (1)». Ceci est fait de deux facons : d’abord a court terme, par l’identification et l’investigation des epidemies, puis a plus long terme, par le suivi et l’etude des tendances de l’incidence et de la prevalence de la maladie afin d’evaluer les besoins et les interventions. Les donnees historiques sont importantes pour connaitre les incidences attendues des infections : les epidemies sont souvent identifiees lorsque l’incidence observee d’une maladie est superieure a l’incidence attendue. L’un des objectifs du reseau de surveillance europeen des salmonelles, Salm-Net, est de creer une base de donnees des salmonelles isolees chez l’homme en Europe (2). Une serie de donnees commune est recueillie pour chaque isolat permettant d’identifier les tendances de l’incidence de la salmonellose en Europe de l’ouest. Ce rapport presente les donnees de 1993 a 1995 pour les deux serotypes de salmonelles les plus couramment rencontres.
Unmet needs in head and neck cancer patients: Unmet needs, emotional disorders, and pain.
Authors: Mario Airoldi, Oliviero Ostellino, Luca Raimondo, Giancarlo Pecorari, Pierfrancesco Franco, Monica Rampino, Giovanni Succo, Martina Denegri, Chiara Tosi, Rossana Botto, Riccardo Torta, Valentina Ieraci
Journal: Journal of Clinical Oncology (2017)

e17501 Background: knowledge is still lacking about head and neck patients’ unmet needs and their association with the other debilitating symptomatologies that worsen Quality of Life (QoL), compliance to treatments and prognosis. The aim of this research, so, it was to investigate the unmet needs of this type of patients in accordance with sympomts. Beside this study tried to evaluate if patients’ needs were correctly understood by their caregivers, nurses and oncologist. Methods: we surveyed 100 patients (80 men and 20 women) with head and neck cancer, during the active phase of chemotherapy treatmet,58 caregivers’ patients, nurses and the oncologist. The axious symptomatology and the depressive symptomatology were assessed by the Hospital Anxiety and Depression Scale (HADS). Distress was assessed by the Distress Thermometer (DT). Unmet needs were assessed from patients and their caregivers by Supportive Care Needs Survey-short Form (SCNS-SF34); nurses and the oncologist had to answer only to the 5 questionnaire’s macro-areas. Pain was assessed using the answer given to the SCNS-SF34’s first item. Results: having unmet needs in the psychological area is associated with the presence of symptoms in the preceding 24 hours (c 2 = 10.213 , p = .001). Unmet needs in the communicative and informative area are associated with pain (c 2 = 5.260 , p = .022). Unmet needs in physical conditions and daily living area are associated with pain (c 2 = 9.962 , p = .002) and the presence of symptoms in the preceding 24 hours (c 2 = 6.760 , p = .009). Unmet needs in patient support and health care area is associated with: distress (c 2 = 4.459 , p = .035), anxious symptomatology (c 2 = 4.071 , p = .044) and pain (c 2 = 14.733 , p = .000). Unmet needs in sexuality area are associated with anxious symptomatology (c 2 = 7.328 , p = .007) and pain (c 2 = 4.833 , p = .028). Feelings about death and dying are associated with anxious symptomatology (c 2 = 6.451 , p = .011) and depressive symptomatology (c 2 = 5.317 , p = .021). Caregivers and patients both detect the presence of unmet needs in many areas. Conclusions: there tare several associations found between unmet needs and main symptomatologies that negatively impact with patient’s QoL and prognosis.
Neoadjuvant randomized trial of degarelix (Deg) ± cyclophosphamide/GVAX (Cy/GVAX) in men with high-risk prostate cancer (PCa) undergoing radical prostatectomy (RP).
Authors: Emmanuel S. Antonarakis, Marianna Zahurak, Edward M. Schaeffer, Alan W. Partin, Ashley Ross, Mohamad Allaf, Jeffrey Tosoian, Thomas Nirschl, Carolyn Chapman, Tanya Skelton O'Neal, Haiyi Cao, Jennifer N. Durham, Gunes Guner, Javier Baena Del Valle, Onur Ertunc, Angelo Demarzo, Charles G. Drake
Journal: Journal of Clinical Oncology (2017)

5077 Background: GVAX-Prostate is a GM-CSF–secreting allogeneic cellular vaccine, whose immunogenicity may be enhanced by androgen ablation as well as low-dose Cy. We conducted a neoadjuvant immunologic study comparing Deg vs. Cy/GVAX→Deg. Methods: Men with high-risk PCa (T1c–3b N0 M0, Gleason 7–10) were randomized 1:1 to Deg(240 mg SQ) vs. Cy(200 mg/m 2 IV)/GVAX(2.5×10 8 PC3 cells, 1.6×10 8 LNCaP cells) given 2 wk before Deg; all pts then had RP 2 wk after Deg. CD8+ T cell and Treg densities in the primary tumor were quantified by IHC (cells/mm 2 ). Clinical endpoints were time-to-PSA-relapse, time-to-next-therapy, and time-to-metastasis. The study was powered (α = 0.05, β = 0.18) to show a 2-fold increase in mean CD8+ density with Cy/GVAX→Deg (Arm B) vs. Deg (Arm A). Results: 28 men were enrolled (Arm A = 15, Arm B = 13). A concurrent control group (N = 20) who did not receive neoadjuvant therapy provided untreated RP tumor samples. Baseline variables were balanced across study arms: 64% had Gleason ≥8, 56% were pT3b, 18% were pN1. There were nonsignificant increases in CD8+ and Treg densities in Arm B vs. A, and statistically significant increases in CD8+ and Treg densities in both arms (A, B) compared to group C (TABLE). CD8+ and Treg densities were strongly correlated. Outcomes were numerically better in Arm B vs A with respect to time-to-PSA-relapse (HR 0.42, 95%CI 0.13–1.38, P= 0.15) and time-to-next-therapy (HR 0.43, 95%CI 0.13–1.39, P= 0.16), although not statistically significant. Conclusions: Intratumoral immune infiltrates were marginally augmented by Cy/GVAX→Deg vs. Deg alone, while CD8+ and Treg densities were significantly greater in both study arms vs. control, supporting the immunogenic effects of androgen ablation. CD8+ / Treg ratios were remarkably consistent across groups. Clinical trial information: NCT01696877. [Table: see text]
A phase I/II safety study of tisotumab vedotin (HuMax®-TF-ADC) in patients with solid tumors
Authors: M. Chenard-Poirier, D.S. Hong, R. Coleman, J. de Bono, M. Mau-Sorensen, D. Collins, S. Lisby, L. Basse, U. Lassen
Journal: Annals of Oncology (2017)
Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes
Authors: Jennifer Karmouch, Qiong Q. Zhou, Christina Y. Miyake, Raffaella Lombardi, Kai Kretzschmar, Marie Bannier-Hélaouët, Hans Clevers, Xander H.T. Wehrens, James T. Willerson, Ali J. Marian
Journal: Circulation Research (2017)

Arrhythmogenic cardiomyopathy is caused primarily by mutations in genes encoding desmosome proteins. Ventricular arrhythmias are the cardinal and typically early manifestations, whereas myocardial fibroadiposis is the pathological hallmark. Homozygous
Estimated Late Health Outcomes in Children Newly Diagnosed with Mature B-Cell Non-Hodgkin Lymphoma Treated with Contemporary LMB Chemotherapy Based upon Similarly Treated Participants in the Childhood Cancer Survivor Study (CCSS)
Authors: Matthew J. Ehrhardt, Yan Chen, John Sandlund, Elizabeth C. Bluhm, Robert J. Hayashi, Wendy M. Leisenring, Monika L. Metzger, Kirsten K. Ness, Kevin R. Krull, Kevin C. Oeffinger, Leslie L. Robison, Yutaka Yasui, Gregory T. Armstrong, Melissa M. Hudson, Daniel A. Mulrooney
Journal: Blood (2016)
Neuropathy and a rash
Authors: Fangyi Xie, Daniel Creamer
Journal: BMJ (2017)

A 26 year old woman was referred to dermatology with a one year history of a rash on her lower legs, abdomen, and arms, and a six month history of paraesthesia in her right hand and left foot. She had no history of fatigue, weight loss, fever, or arthralgia.

There was palpable retiform erythema and broken livedo on her abdomen, arms, and legs (fig 1). She had reduced sensation to light touch in the right ring and little fingers, the lateral palmar and dorsal hand, the left lateral calf, and the dorsum of the left foot. She had a feeling of clumsiness in her right hand that caused her difficulty with writing, but there was no weakness.



Fig 1 
Broken livedo reticularis on abdomen



Blood tests were normal, including a full autoimmune screen. Skin biopsy showed medium vessel vasculitis with fibrinoid necrosis. Electromyography showed sensory damage in the right ulnar nerve and asymmetrical superficial sensory damage in the peroneal nerve, with the left side being affected to a …
Clinical and molecular characteristics of non-small-cell lung cancer (NSCLC) harboring EGFR mutation: results of the nationwide French Cooperative Thoracic Intergroup (IFCT) program
Authors: C. Leduc, J.P. Merlio, B. Besse, H. Blons, D. Debieuvre, P.P. Bringuier, I. Monnet, I. Rouquette, S. Fraboulet-Moreau, A. Lemoine, D. Pouessel, J. Mosser, F. Vaylet, A. Langlais, P. Missy, F. Morin, D. Moro-Sibilot, J. Cadranel, F. Barlesi, M. Beau-Faller
Journal: Annals of Oncology (2017)
GW28-e0695 High-Density Lipoprotein Cholesterol and Cancer Risk Among Chinese with or without Diabetes Mellitus in Kailuan Cohort
Authors: Xumin Guan, Xiao Lei Yang, Yi Heng Yang, Xin Tao Li, Khalid BinWaleed, Rong Feng Zhang, Xiang Gao, Si Yan Zhan, Ying Liu, Hui Hua Li, Shou Ling Wu, Yun Long Xia
Journal: Journal of the American College of Cardiology (2017)
GW28-e0700 Percutaneous coronary intervention for unprotected left main stem: outcomes from a single tertiary centre experience in UK
Authors: Saqib Ghani, Grigoris Karamasis, Firas Al Janabi, Edney Boston Griffiths, Thomas Keeble, John Davies, Kare Tang, Paul Kelly
Journal: Journal of the American College of Cardiology (2017)