tbuckley/cabot-search huggingface dataset:
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
Authors: Kai Xu, Priyamvada Acharya, Rui Kong, Cheng Cheng, Gwo-Yu Chuang, Kevin Liu, Mark K. Louder, Sijy O’Dell, Reda Rawi, Mallika Sastry, Chen-Hsiang Shen, Baoshan Zhang, Tongqing Zhou, Mangaiarkarasi Asokan, Robert T. Bailer, Michael Chambers, Xuejun Chen, Chang W. Choi, Venkata P. Dandey, Nicole A. Doria-Rose, Aliaksandr Druz, Edward T. Eng, S. Katie Farney, Kathryn E. Foulds, Hui Geng, Ivelin S. Georgiev, Jason Gorman, Kurt R. Hill, Alexander J. Jafari, Young D. Kwon, Yen-Ting Lai, Thomas Lemmin, Krisha McKee, Tiffany Y. Ohr, Li Ou, Dongjun Peng, Ariana P. Rowshan, Zizhang Sheng, John-Paul Todd, Yaroslav Tsybovsky, Elise G. Viox, Yiran Wang, Hui Wei, Yongping Yang, Amy F. Zhou, Rui Chen, Lu Yang, Diana G. Scorpio, Adrian B. McDermott, Lawrence Shapiro, Bridget Carragher, Clinton S. Potter, John R. Mascola, Peter D. Kwong
Journal: Nature Medicine (2018)
Documenta Geigy; scientific tables.
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental Investigations into the Emotional Life of the Child Compared with that of the Adult.
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase 3 Study of Tenofovir Alafenamide Compared with Tenofovir Disoproxil Fumarate in Patients with Hbeag-Positive Chronic Hbv: Week 48 Efficacy and Safety Results
Authors: H.L.Y. Chan, S. Fung, W.K. Seto, W.-L. Chuang, C.-Y. Chen, H.J. Kim, A.J. Hui, H.L.A. Janssen, A. Chowdhury, T.Y.O. Tsang, R. Mehta, E. Gane, J.F. Flaherty, B. Massetto, K. Kitrinos, P. Dinh, G.M. Subramanian, J.G. McHutchison, Y.-S. Lim, S.K. Acharya, K. Agarwal
Journal: Journal of Hepatology (2016)
Medical Education Theme Issue 2014
Authors: Robert M. Golub
Journal: JAMA (2014)

The evidence-based medicine movement in medical decision making developed in part as a reaction to a realization that so much of what was taught was done so as received wisdom, not informed by research or even by a strong circumstantial base.1,2 While there is still a good deal of distance to travel in providing a strong evidence base for many clinical decisions, the framework for approaching such questions has become more sophisticated, as has an understanding of how to integrate medical literature into these decisions.3
A Textbook of Pharmacology and Therapeutics
Journal: JAMA (1952)

This work is well known throughout the Scandinavian countries and Germany; its translation into English permits an insight into continental European views. Unlike most works of this character in America, the contents remind one more of a bedside therapeutics than of the science of pharmacology. For instance, the author gives the impression of being skeptical concerning the use of hypophosphites and glycerophosphates, but he does not show why they are valueless, which he no doubt could have done readily. The discussions of the various drugs are extensive from a clinical point of view, and the book is one that may be read with profit by those who desire to compare European opinions with ours.
Взаимосвязь индекса массы тела и углеводного обмена у больных с хроническим панкреатитом
Authors: S.I. Ismailov, F.H. Nazyrov, B.A. Azizov
Journal: GASTROENTEROLOGY (2020)

В работе изучена взаимосвязь между индексом массы тела и нарушением углеводного обмена у больных с хроническим панкреатитом. Прослежена корреляционная связь индекса массы тела с уровнем глюкозы натощак (r = 0,33; р = 0,01), HbA1c (r = 0,32; р = 0,02), иммунореактивного инсулина (r = 0,49; р &lt; 0,0001) и НОМА-IR (r = 0,58; р &lt; 0,0001).
Baicalein Targets GTPase‐Mediated Autophagy to Eliminate Liver Tumor–Initiating Stem Cell–Like Cells Resistant to mTORC1 Inhibition
Authors: Raymond Wu, Ramachandran Murali, Yasuaki Kabe, Samuel W. French, Yi‐Ming Chiang, Siyu Liu, Linda Sher, Clay C. Wang, Stan Louie, Hidekazu Tsukamoto
Journal: Hepatology (2018)

Drug resistance is a major problem in the treatment of liver cancer. Mammalian Target of Rapamycin 1 (mTORC1) inhibitors have been tested for the treatment of liver cancer based on hyperactive mTOR in this malignancy. However, their clinical trials showed poor outcome, most likely due to their ability to upregulate CD133 and promote chemoresistance. The CD133 + tumor–initiating stem cell–like cells (TICs) isolated from mouse and human liver tumors are chemoresistant, and identification of an approach to abrogate this resistance is desired. In search of a compound that rescinds resistance of TICs to mTORC1 inhibition and improves chemotherapy, we identified baicalein (BC), which selectively chemosensitizes TICs and the human hepatocellular carcinoma (HCC) cell line Huh7 cells but not mouse and human primary hepatocytes. Nanobead pull‐down and mass‐spectrometric analysis, biochemical binding assay, and three‐dimensional computational modeling studies reveal BC's ability to competitively inhibit guanosine triphosphate binding of SAR1B guanosine triphosphatase, which is essential for autophagy. Indeed, BC suppresses autophagy induced by an mTORC1 inhibitor and synergizes cell death caused by mTORC1 inhibition in TIC and Huh7 spheroid formation and in the patient‐derived xenograft model of HCC. The BC‐induced chemosensitization is rescued by SAR1B expression and phenocopied by SAR1B knockdown in cancer cells treated with a mTORC1 inhibitor. Conclusion : These results identify SAR1B as a target in liver TICs and HCC cells resistant to mTORC1 inhibition.
Abstract 19230: The CPR “Sweet Spot”: A Target Combination of Optimal Chest Compression Rate and Depth to Achieve Survival With Favorable Neurological Function After Out of Hospital Cardiac Arrest
Authors: Sue Duval, Paul E Pepe, Jeffrey M Goodloe, Atsushi Sugiyama, Demetris Yannopoulos
Journal: Circulation (2016)

Introduction: Collectively, recent studies of out of hospital cardiac arrest (OOHCA) not only confirm that both the CPR chest compression rate (CCR) and depth (CCD) each impact survival, but they a...
Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis
Authors: Geffen Kleinstern, Nicola J. Camp, Lynn R. Goldin, Celine M. Vachon, Claire M. Vajdic, Silvia de Sanjose, J. Brice Weinberg, Yolanda Benavente, Delphine Casabonne, Mark Liebow, Alexandra Nieters, Henrik Hjalgrim, Mads Melbye, Bengt Glimelius, Hans-Olov Adami, Paolo Boffetta, Paul Brennan, Marc Maynadie, James McKay, Pier Luigi Cocco, Tait D. Shanafelt, Timothy G. Call, Aaron D. Norman, Curtis Hanson, Dennis Robinson, Kari G. Chaffee, Angela R. Brooks-Wilson, Alain Monnereau, Jacqueline Clavel, Martha Glenn, Karen Curtin, Lucia Conde, Paige M. Bracci, Lindsay M. Morton, Wendy Cozen, Richard K. Severson, Stephen J. Chanock, John J. Spinelli, James B. Johnston, Nathaniel Rothman, Christine F. Skibola, Jose F. Leis, Neil E. Kay, Karin E. Smedby, Sonja I. Berndt, James R. Cerhan, Neil Caporaso, Susan L. Slager
Journal: Blood (2018)
Transcriptome profiling of hepatitis B virus-infected human hepatocyte derived from chimeric mice with humanized liver
Authors: S. Nakamoto, T. Kanda, S. Wu, K. Takahashi, M. Nakamura, S. Yasui, S. Ogasawara, E. Suzuki, Y. Ooka, T. Saito, A. Tawada, T. Chiba, M. Arai, K. Kobayashi, S. Kiyono, H. Maruyama, N. Kato, H. Shirasawa
Journal: Journal of Hepatology (2018)
Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains
Authors: Lei Zhang, Peng Zhang, Guangfu Wang, Huaye Zhang, Yajun Zhang, Yilin Yu, Mingxu Zhang, Jian Xiao, Piero Crespo, Johannes W. Hell, Li Lin, Richard L. Huganir, J. Julius Zhu
Journal: Neuron (2018)
Local Low Shear Stress and Endothelial Dysfunction in Patients With Nonobstructive Coronary Atherosclerosis
Authors: Gerasimos Siasos, Jaskanwal D. Sara, Marina Zaromytidou, Kyoung H. Park, Ahmet Umit Coskun, Lilach O. Lerman, Evangelos Oikonomou, Charles C. Maynard, Dimitris Fotiadis, Kostas Stefanou, Michail Papafaklis, Lampros Michalis, Charles Feldman, Amir Lerman, Peter H. Stone
Journal: Journal of the American College of Cardiology (2018)
From MGUS to Multiple Myeloma, a Paradigm for Clonal Evolution of Premalignant Cells
Authors: Niels van Nieuwenhuijzen, Ingrid Spaan, Reinier Raymakers, Victor Peperzak
Journal: Cancer Research (2018)

Abstract Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the bone marrow (BM). It represents the final stage in a continuum of PC dyscrasias and is consistently preceded by a premalignant phase termed monoclonal gammopathy of undetermined significance (MGUS). The existence of this well-defined premalignant phase provides the opportunity to study clonal evolution of a premalignant condition into overt cancer. Unraveling the mechanisms of malignant transformation of PC could enable early identification of MGUS patients at high risk of progression and may point to novel therapeutic targets, thereby possibly delaying or preventing malignant transformation. The MGUS-to-MM progression requires multiple genomic events and the establishment of a permissive BM microenvironment, although it is generally not clear if the various microenvironmental events are causes or consequences of disease progression. Advances in gene-sequencing techniques and the use of serial paired analyses have allowed for a more specific identification of driver lesions. The challenge in cancer biology is to identify and target those lesions that confer selective advantage and thereby drive evolution of a premalignant clone. Here, we review recent advances in the understanding of malignant transformation of MGUS to MM. Cancer Res; 78(10); 2449–56. ©2018 AACR.
P249MiR-map: a comprehensive atlas of vascular microRNA expression shows vessel-specific expression profiles of the vasoactive 14q32 microRNAs
Authors: EAC Goossens, PHA Quax, A Y Nossent
Journal: Cardiovascular Research (2018)

Introduction: MicroRNAs are important regulators of cellular and physiological functions, both in health and in disease.Furthermore, most microRNAs display tissue-specific expression patterns.This renders them promising therapeutic targets.However, with regards to cardiovascular disease, vascular microRNA expression profiles are still widely unknown.Even though certain microRNAs have been defined as 'endothelial-specific' or 'smooth muscle cell-specific', little is known about differences in microRNA expression between different types of blood vessels or between different vascular beds.This could have a major impact on future microRNA-based therapeutics.Purpose: Here we aimed to map expression patterns of the vasoactive microRNAs of the 14q32 locus throughout the human vasculature.Methods: We collected 109 different blood vessels as surplus tissue during general and thoracic surgery.Origin of vessels differed widely as well as age, gender and indication of surgery.Tissue samples were collected anonymously and we only recorded the vessel name, indication for surgery, gender and age of the patient.Using rt/qPCR, 17 of the total 54 14q32 microRNAs were measured in each sample.
REVERCE: Randomized phase II study of regorafenib followed by cetuximab versus the reverse sequence for metastatic colorectal cancer patients previously treated with fluoropyrimidine, oxaliplatin, and irinotecan—Biomarker analysis.
Authors: Yasushi Tsuji, Kohei Shitara, Takeharu Yamanaka, Tadamichi Denda, Katsunori Shinozaki, Yoshito Komatsu, Yoshimitsu Kobayashi, Junji Furuse, Hiroyuki Okuda, Masako Asayama, Kohei Akiyoshi, Yoshinori Kagawa, Takeshi Kato, Eiji Oki, Takashi Ando, Yasuhiro Hagiwara, Yasuo Ohashi, Takayuki Yoshino
Journal: Journal of Clinical Oncology (2018)

3510 Background: REVERCE demonstrated longer overall survival (OS) with the therapeutic sequence of regorafenib (R) followed by cetuximab (C) ± irinotecan (R-C arm) compared with that of C ± irinotecan followed by R (C-R arm) for patients (pts) with pretreated metastatic colorectal cancer (mCRC; median OS 17.4 vs. 11.6 months, HR 0.61; Shitara K, et al. GI Symposium 2018). Biomarker analyses assessed the association of multiple candidate biomarkers with clinical outcomes. Methods: Pts with KRAS exon 2 wild-type mCRC after failure of fluoropyrimidine, oxaliplatin, and irinotecan treatment were randomized. The primary endpoint was OS. Key secondary endpoints included progression-free survival (PFS) with initial treatment (PFS1), PFS with second treatment (PFS2), safety, and QOL. Sequential biomarker analysis including oncogenic alterations from ctDNA or multiple serum proteins related to the EGF or VEGF pathway was an exploratory endpoint. Results: Among the randomized 101 pts, plasma and serum samples were collected from 98 pts. OS HR in the biomarker cohort (n = 98, HR 0.61) and all RAS/RAF wild types (n = 86, HR 0.60) at baseline were consistent with that of the overall cohort. R-C arm consistently showed longer OS in all subgroups according to serum proteins biomarkers (median value as cut off). Significant interactions between PlGF or VEGFR-3 level and PFS1 were observed, favoring R over C in higher PlGF and VEGFR-3 level. Among RAS/RAF wild types at baseline, emerging RAS, BRAF, EGFR S492R mutations, and HER2 and MET amplification were observed in 1,0,0,2,2 patients after R and 11,1,2,4,4 patients (overlapping) after C. Conclusions: This trial consistently showed longer OS with R followed by C versus the reverse sequence for pretreated mCRC pts regardless of biomarker subgroups. Emerging oncogenic alterations are more frequently observed after C treatment than R. Clinical trial information: UMIN000011294.
Is Direct Primary Care a Game Changer?
Authors: Rita Rubin
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STRATEGIES TO IMPROVE HOSPITALIZED PATIENT'S QUALITY OF BOWEL PREPARATION FOR COLONOSCOPY: SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: P Gkolfakis, G Tziatzios, IS Papanikolaou, GD Dimitriadis, K Triantafyllou
Journal: Endoscopy (2018)

Bowel preparation in hospitalized patients undergoing colonoscopy is frequently inadequate. Various approaches have been investigated to improve outcomes; however, the most efficient is not determined, yet. The aim of this study was to meta-analyze studies evaluating interventions to improve in-patients’ colon preparation quality.
Controlled attenuation parameter values of Fibroscan ® compatible with steatosis in patients with chronic hepatitis C and changes after sustained virological response
Authors: T. Broquetas, L. Canillas, M. Puigvehí, R. Fernández, G. Díaz, S. Coll, M.G. Retortillo, N. Cañete, X. Bessa, R.S. Lamoglia, J.A. Carrión
Journal: Journal of Hepatology (2018)
Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis
Authors: Conghui Wang, Yuqiang Cheng, Xiuping Zhang, Nan Li, Lin Zhang, Shengdian Wang, Xuemei Tong, Ying Xu, Guo‐qiang Chen, Shuqun Cheng, Xuemei Fan, Junling Liu
Journal: Hepatology (2018)

Polarity defects are frequently involved in liver diseases, such as chronic hepatitis and hepatocellular carcinoma (HCC). It was reported that vacuolar protein sorting 33B (Vps33b) plays critical roles in the maintenance of hepatocyte polarity; however, the functional roles and mechanisms of Vps33b in HCC occurrence and progression remain unknown. First of all, we showed that Vps33b is down‐regulated in human and mouse liver cancer samples, and the low expression levels of Vps33b correlate with the poor prognosis of many HCC patients. Liver‐specific Vps33b deficiency induces liver damage, progressive hepatitis, fibrosis, and HCC in male mice, indicating that Vps33b is a crucial contributory factor to hepatocarcinogenesis. Vps33b deficiency–caused liver damage was primarily due to the disorders of structural and functional hepatocyte polarity, which were reflected by the decreased protein levels of E‐cadherin because of inaccurate location to lysosomes and polarity defects at both apical and lateral plasma membrane proteins. The results of a mechanism study revealed that Vps33b interacts with VPS33B‐interacting protein, which is involved in polarity and apical protein restriction; vesicle‐trafficking protein Sec22b; and Flotillin‐1 in hepatocytes and is in charge of the normal distribution of polarity‐determined proteins. Expression levels of Vps33b negatively correlated with the degree of inflammatory cell infiltration in livers from diethylnitrosamine‐induced or transgenic HCC mouse models, and the inflammatory stimuli suppressed the expression of Vps33b in vitro . Conclusion: Down‐regulation of Vps33b expression is a critical step for inflammation‐driven HCC, and Vps33b serves as an important tumor suppressor in hepatocarcinogenesis.
Nasopharyngeal aspirate value in paediatric chronic lower respiratory tract illness
Authors: Francesca Lunardi, Stefania Edith Vuljan, Egle Perissinotto, Federica Pezzuto, Sandro Malacrida, Samuela Bugin, Ilaria Bertozzi, Deborah Snijders, Stefania Rizzo, Angelo Barbato, Fiorella Calabrese
Journal: European Respiratory Journal (2018)

<b>Nasopharyngeal aspirate as a sensitive and specific surrogate tool for the detection of respiratory viruses in different forms of chronic/recurrent lower respiratory tract illness</b>http://ow.ly/cd8S30jcwyu
Enabling multiplexed testing of pooled donor cells through whole-genome sequencing
Authors: Yingleong Chan, Ying Kai Chan, Daniel B. Goodman, Xiaoge Guo, Alejandro Chavez, Elaine T. Lim, George M. Church
Journal: Genome Medicine (2018)

We describe a method that enables the multiplex screening of a pool of many different donor cell lines. Our method accurately predicts each donor proportion from the pool without requiring the use of unique DNA barcodes as markers of donor identity. Instead, we take advantage of common single nucleotide polymorphisms, whole-genome sequencing, and an algorithm to calculate the proportions from the sequencing data. By testing using simulated and real data, we showed that our method robustly predicts the individual proportions from a mixed-pool of numerous donors, thus enabling the multiplexed testing of diverse donor cells en masse. More information is available at https://pgpresearch.med.harvard.edu/poolseq/
Real world effectiveness of Ledipasvir/Sofosbuvir based regimens in hepatitis C virus genotype 1,2 and 3 infection within national hepatitis C elimination program in the country of Georgia
Authors: T. Tsertsvadze, N. Chkhartishvili, A. Abutidze, L. Sharvadze, V. Kerashvili, M. Butsashvili, J. Zarkua, B. Skaggs, L. Gvinjilia, S. Shadaker, M. Nasrullah, A. Gamkrelidze, V. Kvaratskhelia, N. Afdhal, S. Zeuzem, S. Arora, K. Thornton, F. Averhoff
Journal: Journal of Hepatology (2018)
A digital microfluidic system for serological immunoassays in remote settings
Authors: Alphonsus H. C. Ng, Ryan Fobel, Christian Fobel, Julian Lamanna, Darius G. Rackus, Aimee Summers, Christopher Dixon, Michael D. M. Dryden, Charis Lam, Man Ho, Nooman S. Mufti, Victor Lee, Mohd Afiq Mohd Asri, Edward A. Sykes, M. Dean Chamberlain, Rachael Joseph, Maurice Ope, Heather M. Scobie, Alaine Knipes, Paul A. Rota, Nina Marano, Paul M. Chege, Mary Njuguna, Rosemary Nzunza, Ngina Kisangau, John Kiogora, Michael Karuingi, John Wagacha Burton, Peter Borus, Eugene Lam, Aaron R. Wheeler
Journal: Science Translational Medicine (2018)

Portable digital microfluidic serological immunoassays for measles and rubella were developed and evaluated in a remote setting.
P502Curcumin attenuates H9c2 cell ischemia/reperfusion injury via activating SIRT3 and inhibiting oxidative stress
Authors: D Liu
Journal: Cardiovascular Research (2018)

Fig. 1B).Measures were grouped by zones distinguish between the normal zone, the heterogeneous tissue present at the scar border zone and the conduction channels.Results: During pacing, APD presented values of 194 6 48 ms in the the normal zone, 222 6 52 ms in the heterogeneous tissue present at the scar border zone, 281 6 61 ms in the conduction channels, differences were identified between the regions under study (p<0.05).CV was 75.6 6 12.2 cm/s, 52.5 6 7.2 cm/s, 33.7 6 7.9 cm/s (p<0.05) for the same areas listed before.Finally, during ventricular tachycardia CV in the border area of infarction presented values of 17.3 6 9.2 cm/s whereas APD was 213 6 12 ms, the area farthest from the infarct presented values of 52.4 6 12.3 cm/s and 181 6 9 ms (p<0.05) (Fig. 1C).Conclusions: Initiation and maintenance or ventricular tachycardia is associated with heterogeneity on APD duration and CVs.This chronic infarction swine model is a consistent ventricular tachycardia model, which simulates realistic tachyarrhythmias.High-resolution optical mapping in this model is useful to study the mechanism of ventricular tachycardia and evaluate the effects of different therapies.