tbuckley/cabot-search huggingface dataset:
Studies in Carcinogenesis. XV. Compounds Related to 20-Methylcholanthrene&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: M. J. Shear, Joseph Leiter, Adrien Perrault
Journal: JNCI Journal of the National Cancer Institute (1941)

Journal Article Studies in Carcinogenesis. XV. Compounds Related to 20-Methylcholanthrene Get access M. J. Shear, M. J. Shear principal biochemist Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph Leiter, Joseph Leiter junior chemist Search for other works by this author on: Oxford Academic PubMed Google Scholar Adrien Perrault Adrien Perrault assistance of scientific aide National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 2, October 1941, Pages 99–113, https://doi.org/10.1093/jnci/2.2.99 Published: 01 October 1941
Caffeic acid phenethyl ester (CAPE, a product of propolis) as an inhibitor of human breast cancer growth in a pre-clinical study and its effects on factors involved in cell cycle, angiogenesis, and drug resistance
Authors: Jing Wu, Usha Bukkapatnam, Jonathan Eckard, Krystyna Frenkel
Journal: Cancer Research (2008)

5710  Our original goal has been to establish whether caffeic acid phenethyl ester (CAPE), a bioactive anti-inflammatory component of the propolis, a product of honeybees, can suppress breast cancer formation using a xenograft nude mouse model. We found that orally administered CAPE inhibits growth of human breast cancer cells in nude mice regardless of whether these cells are estrogen receptor (ER) positive (MCF-7) or negative [MDA-MB-231 (MDA-231)] cells. This finding is additionally important because there are fewer therapies available for ER negative tumors. The suppression of xenograft growth was most effective at very low doses of 50 nmol (14.2 μg) CAPE/mouse/day for MCF-7 and 10 nmol (2.84 μg) for MDA-231 xenografts when mice were provided CAPE-containing diets two days prior to cell inoculation for up to 45-60 days afterwards. Toxicity and Drug Resistance gene microarrays using MCF-7 and MDA-231 cells showed that CAPE causes strong down-regulation of anti-apoptotic and cell proliferation genes, as well as of NF-κB transcription factors. Notably, multi-drug resistance 1 (mdr-1) gene was decreased in MDA-231 cells about 4-fold by CAPE, which strongly suggests that CAPE could be useful as an adjuvant to therapeutic drugs, such as paclitaxel (Taxol), which are expelled from tumor cells by mdr-1 protein products. Our preliminary results show that treatment of MDA-231 cells with low doses of CAPE (0.5-20 μM) followed 15 min later with Taxol (1-5 nM) show a dose-dependent decrease in cell viability, with optimal conditions being 1 nM Taxol and 1-5 μM CAPE. Since growth of tumors in vivo requires neovascularization, we also looked for the effects of CAPE on the formation of VEGF, an angiogenic factor, in cultured cells. CAPE had no effect on low VEGF (vascular endothelial growth factor) produced by MCF-7 cells, but dose-dependently inhibited VEGF formation by MDA-231 cells. We also found that a low CAPE dose inhibits formation of capillary-like tubes by endothelial cells. These results suggest that CAPE should inhibit angiogenesis also in mice growing human breast cancer xenografts. We also found that CAPE dose-dependently inhibits viability of both types of cells by enhancing formation of p21 and p27 cell cycle inhibitory proteins and increasing apoptosis. In conclusion, CAPE seems to be very promising as an anti-breast cancer agent because of its anti-proliferative and pro-apoptotic effects, as well as inhibiting angiogenesis. Notably, CAPE also decreases heat shock protein genes as well as mdr-1 and its protein products responsible for drug resistance, thus holding a promise for increasing effectiveness of chemotherapeutic drugs and decreasing their side effects. [This work was supported in part by grants from Susan G. Komen for Cure Foundation (BCTR0600476) and NIEHS (ES00260)]
Communicating About Vaccines in a Fact-Resistant World
Authors: Saad B. Omer, Avnika B. Amin, Rupali J. Limaye
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Clonal chromosomal abnormalities appearing in Philadelphia chromosome–negative metaphases during CML treatment
Authors: Ghayas C. Issa, Hagop M. Kantarjian, Graciela Nogueras Gonzalez, Gautam Borthakur, Guilin Tang, William Wierda, Koji Sasaki, Nicholas J. Short, Farhad Ravandi, Tapan Kadia, Keyur Patel, Raja Luthra, Alessandra Ferrajoli, Guillermo Garcia-Manero, Mary Beth Rios, Sara Dellasala, Elias Jabbour, Jorge E. Cortes
Journal: Blood (2017)
A pointer's hypothesis of general intelligence evolved from domain-specific demands
Authors: X T Xiao-Tian Wang
Journal: Behavioral and Brain Sciences (2017)

Abstract A higher-order function may evolve phylogenetically if it is demanded by multiple domain-specific modules. Task-specificity to solve a unique adaptive problem (e.g., foraging or mating) should be distinguished from function-specificity to deal with a common computational demand (e.g., numeracy, verbal communication) required by many tasks. A localized brain function is likely a result of such common computational demand.
Cardiovascular screening practices in US National Governing Bodies and National Paralympic Committees
Authors: Brett G Toresdahl, Cindy Chang, Jamie Confino, Irfan M Asif
Journal: British Journal of Sports Medicine (2017)

Cardiovascular screening in athletes has been a source of controversy within the sports medicine community. Annual screening inclusive of ECG is currently required by all major professional sports leagues in the USA and recommended by the IOC.1 In 2016, the American Medical Society for Sports Medicine (AMSSM) published a statement on cardiovascular screening, recognising knowledge gaps and advocating for medical providers caring for competitive athletes to consider important factors when determining an individualised cardiovascular screening strategy. These include the risk of sudden cardiac arrest (SCA) in the specific athlete population, the available resources and cardiology infrastructure for screening and secondary evaluations.2 

The purpose of this investigation was to determine the cardiovascular screening practices of the US National Governing Bodies (NGBs) and National Paralympic Committees (NPCs). This study was approved by the Institutional Review Board from the …
&lt;italic&gt;Trans&lt;/italic&gt; Fatty Acids in Tumor Development: Reply
Authors: Atif B. Awad, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1982)

Trans Fatty Acids in Tumor Development: Reply Get access Atif B. Awad, Ph.D. Atif B. Awad, Ph.D. Department of Biochemistry Kirksville College of Osteopathic Medicine, Kirksville, Missouri 63501 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 69, Issue 2, August 1982, Pages 320–321, https://doi.org/10.1093/jnci/69.2.320 Published: 01 August 1982
Sharing Experiences of Illness and Care
Authors: Louise Locock, Richard Lehman, Ronald M. Epstein
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Prognostic Value of Primary Tumor Volume Changes on kV-CBCT during Definitive Chemoradiotherapy for Stage III Non–Small Cell Lung Cancer
Authors: Patrick Wald, Xiaokui Mo, Christian Barney, Daniel Gunderson, A. Karl Haglund, Jose Bazan, John Grecula, Arnab Chakravarti, Terence Williams, David P. Carbone, Meng Xu-Welliver
Journal: Journal of Thoracic Oncology (2017)
Abstract 15378: Mitochondrial Fission Plays a Crucial Role in Cardiomyocyte Adaptation to Energy Stress via Mitophagy
Authors: Yoshiyuki Ikeda, Yasuhiro Maejima, Mitsuru Ohishi, Junichi Sadoshima
Journal: Circulation (2014)

Mitochondria are dynamic organelles that undergo fusion and fission. This study aims to clarify the role of mitochondrial dynamics on energetic stress resistance in cardiomyocytes (CMs). Dynamin-related protein 1 (Drp-1) which mediates mitochondrial fission was localized primarily in the cytosol in CMs. Glucose deprivation (GD) induced modest mitochondrial accumulation of Drp1 in CMs within 4 hours. Four-hour GD increased the proportion of CMs with fused mitochondria (23.5±6.9 to 35.0±10.8%, p&lt;0.05), but also increased that of CMs with fission (2.1±0.3 to 15.5±4.8%, p&lt;0.05) in Ad-shScr-transduced CMs, whereas mitochondria with fission did not increase after GD in Ad-shDrp1-transduced CMs (0.3±0.6 to 0.8±0.5%). These results suggest that GD induces both mitochondrial fusion and fission, and Drp1 plays an essential role in mitochondrial fission in response to GD. Transduction with Ad-shDrp1 significantly increased TUNEL-positive CMs and reduced cell viability after 4 hours of GD compared to transduction with Ad-shScr, suggesting that endogenous Drp1 protects CMs against cell death during GD. We evaluated the role of Drp1 in mediating mitophagy using mitochondria-targeted Keima fluorescence. Keima has a bimodal excitation spectrum peaking at 440 and 560 nm, corresponding to the neutral and acidic pH states, respectively. Puncta with high 560/440, indicating the presence of mitochondria in lysosomes, were significantly increased after 4 hours of GD in CMs transduced with Ad-shScr, but not in CMs transduced with Ad-shDrp, suggesting that Drp1 is necessary for stimulating autophagic mitochondrial degradation. Next, we examined the role of fission on energy stress in vivo using cardiac specific Drp1 hetero knockout (Drp1-hetCKO) mouse. Translocation of Drp1 from cytosol to mitochondria significantly increased in response to 48-hour fasting in control mice but not in Drp1-hetCKO mice. Left ventricular ejection fraction did not change after fasting in control mice (79.8±6.4 to 78.6±8.3%). However that in Drp1-hetCKO mice decreased after GD (79.4±9.7 to 48.3±11.6%, p&lt;0.05), suggesting that Drp1 acts to preserve cardiac function during fasting. In conclusion, mitochondrial fission is crucial to adapt CMs to energy stress through mitophagy.
Fooling the brain to alleviate dyspnoea
Authors: Capucine Morélot-Panzini
Journal: European Respiratory Journal (2017)

Dyspnoea affects a multitude of patients with a multitude of diseases, and therefore concerns a multitude of physicians and other healthcare professionals. In view of the physical and psychological distress associated with dyspnoea, and in view of the pervasive impact of dyspnoea on the patient's psychological state and social life [1, 2], relieving dyspnoea should constitute a leading and universal clinical goal. Some have even proposed that failing to provide a patient with dyspnoea with "state of the art" management of this symptom would constitute an infringement of human rights [3, 4]. The application of a stream of air onto the face by a hand-held fan has a real place in the treatment of dyspnoea <http://ow.ly/tKJk30dJ5Pv>
Diagnostic Performance of Hybrid Cardiac Imaging Methods for Assessment of Obstructive Coronary Artery Disease Compared With Stand-Alone Coronary Computed Tomography Angiography
Authors: Asim Rizvi, Donghee Han, Ibrahim Danad, Bríain Ó Hartaigh, Ji Hyun Lee, Heidi Gransar, Wijnand J. Stuijfzand, Hadi Mirhedayati Roudsari, Mahn Won Park, Jackie Szymonifka, Hyuk-Jae Chang, Erica C. Jones, Paul Knaapen, Fay Y. Lin, James K. Min, Jessica M. Peña
Journal: JACC. Cardiovascular imaging (2017)

The current meta-analysis aimed to evaluate the diagnostic performance of hybrid cardiac imaging techniques compared with stand-alone coronary computed tomography angiography (CTA) for assessment of obstructive coronary artery disease (CAD).The usefulness of coronary CTA for detecting obstructive CAD remains suboptimal at present. Myocardial perfusion imaging encompasses positron emission tomography, single-photon emission computed tomography, and cardiac magnetic resonance, which permit the identification of myocardial perfusion defects to detect significant CAD. A hybrid approach comprising myocardial perfusion imaging and coronary CTA may improve diagnostic performance for detecting obstructive CAD.PubMed and Web of Knowledge were searched for relevant publications between January 1, 2000 and December 31, 2015. Studies using coronary CTA and hybrid imaging for diagnosis of obstructive CAD (a luminal diameter reduction of >50% or >70% by invasive coronary angiography) were included. In total, 12 articles comprising 951 patients and 1,973 vessels were identified, and a meta-analysis was performed to determine pooled sensitivity, specificity, and summary receiver-operating characteristic curves.On a per-patient basis, the pooled sensitivity of hybrid imaging was comparable to that of coronary CTA (91% vs. 90%; p = 0.28). However, specificity was higher for hybrid imaging versus coronary CTA (93% vs. 66%; p < 0.001). On a per-vessel basis, sensitivity for hybrid imaging against coronary CTA was comparable (84% vs. 89%; p = 0.29). Notably, hybrid imaging yielded a specificity of 95% versus 83% for coronary CTA (p < 0.001). Summary receiver-operating characteristic curves displayed improved discrimination for hybrid imaging beyond coronary CTA alone, on a per-vessel basis (area under the curve: 0.97 vs. 0.93; p = 0.047), although not on a per-patient level (area under the curve: 0.97 vs. 0.93; p = 0.132).Hybrid cardiac imaging demonstrated improved diagnostic specificity for detection of obstructive CAD compared with stand-alone coronary CTA, yet improvement in overall diagnostic performance was relatively limited.
High 18Fluor-DCFPyL Uptake in Adrenal Adenomas
Authors: Johannes Gerrit Karel Peper, Sandra Srbljin, Friso Martijn van der Zant, Remco Johannes Jacob Knol, Maurits Wondergem
Journal: Clinical Nuclear Medicine (2017)

Abstract Radioisotope-labeled prostate-specific membrane antigen (PSMA) tracers have been proven accurate for detection of prostate cancer localizations. Uptake of those tracers in other malignant and benign lesions has been reported, including faint accumulation of 68 Ga-PSMA-HBED-CC in adrenal adenoma. A 77-year-old man with prostate carcinoma was scanned with 18 F-DCFPyL, a promising 18 F-labeled PSMA ligand, for prostate-specific antigen progression while on luteinizing hormone–releasing hormone agonist therapy. The PET/CT shows 18 F-DCFPyL uptake in bilateral enlarged adrenals. Non–contrast-enhanced CT scan indicated left adrenal adenoma. Regarding the high positive predictive value of multiphase contrast-enhanced CT (98%), presence of right adrenal adenoma is also likely.
Abstract 235: Global RNA Splicing and Regulation in Cardiac Maturation and Diseases
Authors: CHEN GAO, Vincent Ren, Jae-Hyung Lee, Xinshu (Grace) Xiao, Jau-nian Chen, Yibin Wang
Journal: Circulation Research (2013)

Background: The complexity of transcriptome and proteome is contributed by alternative splicing of mRNA. Altered mRNA splicing is also implicated in many human diseases including cancer. However, the global pattern of alternative mRNA splicing during cardiac development and diseases is unknown, and the regulatory mechanisms remain unexplored. Methods and Results: Using deep RNA-Sequencing, we have identified global alternative splicing changes associated with both cardiac development and pathological remodeling in mouse heart following pressure-overload induced heart failure. The alternative RNA splicing events observed in failing hearts mimics the profile in fetal hearts, suggesting a fetal-like RNA splicing program induced in diseased hearts. Using RNA-Seq database and real-time PCR analysis, we examined the expression profile of a large number of known alternative splicing regulators. Among them, we identified Fox1 as a significantly induced regulator during cardiac development in zebrafish, mouse and human, and down-regulated in both mouse and human failing hearts. Morpholino mediated Fox1 knockdown in zebrafish embryos led to lethal phenotype associated with reduced cardiac function and defects in chamber specificity. This phenotype could be rescued by re-expressing both zebrafish and mouse Fox1 gene, suggesting a highly conserved cardiac function of Fox1 for normal cardiac development and function in vertebrates. Conclusion: Our study provided the first comprehensive analysis of mRNA splicing regulation in heart during post-natal development and heart failure, and identified Fox1 as a key regulator for alternative RNA splicing in heart. This study expands our current understanding to the complexity of cardiac transcriptome, and reveals the functional importance of RNA-splicing in cardiac development and diseases.
Vincristine toxicity with co-administration of triazole antifungals during induction therapy for pediatric acute lymphoblastic leukemia.
Authors: Andrew Brian Smitherman, Michael Troy, Cassidy Beach, Allison Mary Deal, Stuart H. Gold
Journal: Journal of Clinical Oncology (2016)

10535 Background: Antifungal prophylaxis is recommended for intermediate and high-risk patients with acute lymphoblastic leukemia (ALL) during periods of prolonged neutropenia such as induction therapy. However, increased vincristine toxicities among childhood leukemia patients have been reported with the co-administration of triazole antifungals. We examined the association between triazoles and vincristine-related toxicities among pediatric patients with ALL undergoing induction therapy. Methods: Using a retrospective cohort design, we reviewed the charts of all pediatric patients (0-18 years-old) treated for newly-diagnosed ALL at the North Carolina Children’s Hospital from 2003 to 2013. Patients were classified according to whether or not they received a triazole antifungal during induction therapy. The presence of any vincristine-associated toxicity was the primary outcome. Using a log binomial model, the adjusted relative risk for vincristine-related toxicity associated with triazole exposure was determined. Results: We identified 219 patients treated for ALL during the study period; 199 met inclusion criteria for evaluation. The mean age was 6.3 years (SD 4.4) with a male predominance (60%). Sixty-three percent were Caucasian, 16% Hispanic, and 14% African American. Most patients (85%) had B-cell phenotype, and 50% were standard risk. One hundred and sixty-two patients (81%) received a triazole with the majority being fluconazole (N = 160, 80%). Adjusting for patient age and race, no increased risk for vincristine-associated toxicity with triazole exposure was observed (RR 1.4, 95%CI 0.65-2.88). Age ≥ 10 years was independently associated with an increased risk for vincristine-associated toxicity (RR 1.9, 95%CI 1.20-3.17). Conclusions: Co-administration of fluconazole during induction therapy for pediatric ALL does not increase the risk for vincristine-associated toxicities; however, patients 10 years-old and older are at increased risk for toxicity independent of their triazole exposure. Prophylaxis with fluconazole can be used during induction therapy for pediatric ALL without increased vincristine-associated toxicities.
Baseline levels of urinary 8-oxodeoxyguanosine and hepatocellular carcinoma risk
Authors: Hui-Chen Wu, Qiao Wang, Lian-Wen Wang, Hwai-I Yang, Li-Yu Wang, Shu-Yuan Chen, Habibul Ahsan, Wei-Yann Tsai, Chien-Jen Chen, Regina M. Santella
Journal: Cancer Research (2006)

921   To determine the association between the urinary excretion of 8-oxodeoxyguanosine (8-oxo-dG) and risk of hepatocellular carcinoma, a case-control study nested within a community based cohort was conducted in Taiwan. Baseline urine samples, collected from a total of 73 HCC cases and 297 matched controls, were used to determine the level of urinary 8-oxo-dG by competitive enzyme-linked immunosorbent assay. Conditional logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) to assess the effect of urinary 8-oxo-dG on risk of HCC. The geometric mean of urinary 8-oxo-dG was 75.0 ng/μl in HCC cases and 75.5 ng/μl in controls. When compared to subjects in the lowest tertile, there was a decreased trend (p trend =0.17) in risk of HCC, with increasing tertile of 8-oxodG level (OR=0.78, 95% CI=0.34-1.80; OR=0.55, 95% CI=0.23-1.32, for the 2 nd  and 3 rd  tertile relative to the lowest tertile, respectively). In addition, the protective effect of urinary 8-oxo-dG level on HCC risk were only observed among subjects positive for HBsAg. The ORs were 0.26 (95%CI=0.03-2.56), 0.02 (95%CI=0.0-0.78, p trend  nd , and 3 rd  tertile, compared with those in the lowest tertile. Among HBsAg negative subjects, the ORs were 1.59 (95% CI=0.50-5.01), 1.48 (95%CI=0.51-4.27), respectively. Subjects positive for HBsAg and with urinary 8-oxo-dG levels below the mean had a significantly increased HCC risk (OR=27.31, 95%CI=8.07-92.50) compared to subjects negative for HBsAg and with urinary 8-oxo-dG above the mean (p trend
Influence of Overlapping Genetic Abnormalities on Treatment Outcomes of Multiple Myeloma
Authors: Samer A. Srour, Rima M Saliba, Ruby Delgado, Muzaffar H. Qazilbash, Qaiser Bashir, Nina Shah, Uday R. Popat, Sairah Ahmed, Krina Patel, Roy Jones, Gabriela Rondon, Richard E. Champlin, Yago Nieto
Journal: Blood (2016)
Metabolic differentiation of early Lyme disease from southern tick–associated rash illness (STARI)
Authors: Claudia R. Molins, Laura V. Ashton, Gary P. Wormser, Barbara G. Andre, Ann M. Hess, Mark J. Delorey, Mark A. Pilgard, Barbara J. Johnson, Kristofor Webb, M. Nurul Islam, Adoracion Pegalajar-Jurado, Irida Molla, Mollie W. Jewett, John T. Belisle
Journal: Science Translational Medicine (2017)

Metabolic profiling provides a biochemical signature to objectively differentiate two illnesses with nearly identical clinical presentations, early Lyme disease and STARI.