tbuckley/cabot-search huggingface dataset:
Un brote de listeriosis asociado a queso tierno en el noroeste de Suiza, 2005
Authors: J Bille, D S Blanc, H Schmid, K Boubaker, A Baumgartner, H H Siegrist, M L Tritten, R Lienhard, D Berner, R Anderau, M Treboux, J M Ducommun, R Malinverni, D Genné, P Erard, U Waespi
Journal: Eurosurveillance (2006)

En la primavera de 2005 se declararon diez casos de listeriosis en una region (150.000 habitantes) del noroeste de Suiza durante un periodo de ocho semanas. Eran ocho pacientes imunodeprimidos con bacteriemia (tres defunciones), y dos mujeres embarazadas que tuvieron un aborto septico. Todos los casos fueron debidos al serotipo 1/2a, con uno de dos pulsotipos identificados por electroforesis en campo pulsado (PFGE). Las entrevistas con los pacientes revelaron rapidamente que un queso tierno llamado « tomme », fabricado y distribuido localmente, era la fuente alimentaria implicada en el brote. Se identifico L. monocytogenes sv 1/2a del mismo pulsotipo en las muestras de ese queso, como tambien en la mantequilla fabricada en la misma lecheria, en cantidades de 1.000-10.000 y 10-100 ufc/g, respectivamente. Tras la interrupcion inmediata de la produccion, la retirada del queso del mercado y una alerta publica, se termino el brote. El hecho de que ese queso contaminado fuera distribuido en un area limitada, la colaboracion de los medicos locales, de los microbiologos medicos y de los servicios sanitarios alimentarios contribuyeron al exito y a la rapidez de la investigacion. 
Este pequeno brote de listeriosis subrayo la importancia de un sistema de vigilancia basada en los laboratorios con una tipificacion rapida, y de la colaboracion entre medicos y microbiologos.
Primary care management of postoperative shoulder, hip, and knee arthroplasty
Authors: Nick Aresti, Jamila Kassam, Daniel Bartlett, Satish Kutty
Journal: BMJ (2017)

#### What you need to know The number of orthopaedic operations is increasing in the UK: the National Joint Registry reported just under 225 000 procedures in the period ending 2015-16.1 This practice pointer aims to inform the readership of the important considerations about arthroplasty of the knee, hip, and shoulder—the most common arthroplasty procedures performed in the UK. Arthroplasty in now routinely used to treat fractures and rotator cuff arthropathy. In 2015 in the UK over 83 000 primary total hip replacements took place, of which over 3700 were for neck of femur fractures, and over 4200 shoulder arthroplasties were performed for cuff arthropathy, representing around a quarter of all shoulder replacements.1 Enhanced recovery programmes have seen better standardisation of arthroplasty care and are now fully implemented in the NHS. They have been shown to reduce mortality, length of hospital stay, and transfusion requirements.2 They have four main steps, summarised in box 1. #### Box 1: Enhanced recovery programme steps: ##### Step 1. Improve preoperative care ##### Step 2. Reduce the physical stress of the operation ##### Step 3. Decreasing postoperative discomfort
TCT-495 Percutaneous extracorporeal life support in the catheterization laboratory for refractory cardiac arrest in a center without on-site cardiovascular surgery
Authors: Sebastian Voicu, Jean Guillaume Dillinger, Anastasios Koumoulidis, Damien Logeart, Nikolaos Magkoutis, Stephane Manzo-Silberman, Demetris Yannopoulos, Nicolas Deye, Bruno Megarbane, Patrick Henry, Georgios Sideris
Journal: Journal of the American College of Cardiology (2017)
Provision of occupational health for all at work
Authors: Anne M de Bono
Journal: BMJ (2017)

Duncan Selbie, chief executive of Public Health England, reminds us that health, wealth, and a thriving economy are inseparable.1

He says that small businesses should follow the example of large employers in providing help for employees with musculoskeletal and mental health problems, the commonest causes of absence from and loss of work. The connection between …
TCT-132 Strut thickness impact on thrombogenicity in BRS: In-vitro insights
Authors: Shengjie Lu, Jaryl Ng, Hui Ying Ang, Valeria Paradies, Philip Wong, Rasha Al-Lamee, Kadem Al-Lamee, Nial Bullett, Naveed Ahmed, Michael Joner, Nicolas Foin
Journal: Journal of the American College of Cardiology (2017)
Sulfur Distribution in Extracts of Normal and Neoplastic Tissues
Authors: Greenstein, Jesse P., Leuthardt, Florence M.
Journal: JNCI Journal of the National Cancer Institute (1944)

Journal Article Sulfur Distribution in Extracts of Normal and Neoplastic Tissues Get access Jesse P. Greenstein, Jesse P. Greenstein senior biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Florence M. Leuthardt Florence M. Leuthardt laboratory technician National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 5, Issue 2, October 1944, Pages 111–114, https://doi.org/10.1093/jnci/5.2.111 Published: 01 October 1944
MOLES AND MALFORMATIONS OF THE SKIN IN THEIR RELATIONSHIP TO INHERITANCE AND PHYLOGENESIS.
Authors: E. MEIROWSKY
Journal: British Journal of Dermatology (1942)

Journal Article MOLES AND MALFORMATIONS OF THE SKIN IN THEIR RELATIONSHIP TO INHERITANCE AND PHYLOGENESIS: (NEW AND OLD INVESTIGATIONS.) Get access E. MEIROWSKY E. MEIROWSKY London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 54, Issue 4, 1 April 1942, Pages 99–121, https://doi.org/10.1111/j.1365-2133.1942.tb10622.x Published: 01 April 1942
Situación actual de la difilobotriasis en Europa
Authors: J Dupouy-Camet, R Peduzzi
Journal: Eurosurveillance (2004)

La difilobotriasis, parasitosis causada por la tenia Diphyllobothrium latum se contrae por el consumo de pescado de agua dulce crudo o mal cocido. El objetivo de la encuesta era evaluar la situacion de esta parasitosis en los ultimos veinte anos en Europa, utilizando el analisis de bases de datos y herramientas de busqueda (Medline, Cabi Helminthological abstracts, Yahoo, Google), con un cuestionario enviado a una red de parasitologos europeos y a laboratorios microbiologicos situados en las orillas de los grandes lagos alpinos. La encuesta mostro que en Finlandia y en Suecia se notificaban anualmente varias docenas de casos, que habia numerosos casos en las areas de habla francesa o italiana de los lagos subalpinos y que solo se producian casos esporadicos en Austria, Espana, Grecia, Rumania, Polonia y en Noruega. Desde 1990, se identificaron mas de treinta casos en la orilla suiza del lago Mayor, y 70 casos entre 1993 y 2002 en las orillas suizas y francesas del lago Leman. El 8-12% de los filetes de perca del lago Leman y un 7,8% de las percas del lago Mayor contienen larvas infestantes. Las fuentes de contaminacion son los filetes marinados de pescado en el norte de Europa, el carpaccio di persico en Italia del norte, y tambien la perca y el salmon alpino consumidos crudos o mal cocidos en las orillas del lago Leman. El vertido persistente de aguas residuales en los lagos, los navegantes deportivos - frecuentemente pescadores deportivos, y la posibilidad de un reservorio animal son factores que permiten la continuidad del ciclo del parasito.
Cardiac Magnetic Resonance as an Alternative to Endomyocardial Biopsy to Predict Recoverability of Left Ventricular Function in Methamphetamine- Associated Cardiomyopathy
Authors: Margarida Pujol-López, Luis Ortega-Paz, Eduardo J. Flores-Umanzor, Rosario J. Perea, Xavier Bosch
Journal: JACC Heart Failure (2017)
Deciphering the biology of IgG4-related disease: specific antigens and disease?
Authors: Debashis Haldar, Gideon M Hirschfield
Journal: Gut (2017)

Immunoglobulin G4-related disease (IgG4-RD) is the name applied to a corticosteroid and/or B-cell depletion responsive illness, in which patients present with the consequences of usually multiorgan, relapsing and remitting, fibroinflammation.1 The disease is histologically characterised by obliterative phlebitis, storiform fibrosis and a dense lymphoplasmacytic infiltrate.2 IgG4-RD is not a new disease, but is benefiting from the application of new technologies in the pursuit of better biological understanding. The histologic enrichment of IgG4-expressing plasma cells is a diagnostic hallmark of disease that additionally serves as a biological phenomenon driving scientific evaluation.3 Key disease themes have evolved to include a large clonal expansion of activated plasmablasts and CD4+ cytotoxic, inflammatory and profibrotic lymphocytes. Therapeutically, a reduced frequency of CD4+ cytotoxic lymphocytes are seen after B-cell depletion; such therapy may consequently impact on antigen presentation.4–6 To date, the activity of IgG4-RD is not readily tracked by disease biomarkers with even serum IgG4 concentration remaining an imperfect diagnostic and prognostic tool for many patients.7 

IgG4 molecules have structural and functional characteristics suggesting anti-inflammatory and tolerance-inducing effects,8 9 and in IgG4-RD a reported oligoclonal reactivity to multiple antigens.4 10 In Gut , Hubers et al describe a body of work that identifies the first IgG4 autoantibody against an antigen which appears to be specific to IgG4-RD (IgG4-associated cholangitis (IAC) and autoimmune pancreatitis (AIP)), at the exclusion of its major differential diagnoses: primary sclerosing cholangitis and cholangiocarcinoma.11 The authors demonstrate that patients with IgG4-RD raise IgG1 and IgG4 in their sera that recognise a 56 kDa cytosolic protein in an immortalised cell line lysate (H69 cholangiocytes) and in human liver lysate. Both IgG1 and IgG4 antibodies recognise the same 56 kDa protein, and subsequent label-free quantitative liquid chromatography-tandem mass spectrometry analysis and immunoprecipitation identifies the cytosolic protein, Annexin A11, as the target. Annexin A11 IgG4 …
Effective Prostate-Specific Membrane Antigen–Based 18F-DCFPyL–Guided Cryoablation of a Single Positive Site in a Patient Believed to Be More Metastatic on 11C-Choline PET/CT
Authors: Francois H. Cornelis, Jeremy C. Durack, Michael J. Morris, Howard I. Scher, Stephen B. Solomon
Journal: Clinical Nuclear Medicine (2017)

PET/CT-guided interventions using specific radiotracers are promising for detecting avid lesions not well visualized with other imaging methods. A 72-year-old man who initially presented with prostate cancer Gleason 5 + 4 (prostate-specific antigen [PSA] = 7.9 ng/mL) underwent radical prostatectomy and node dissection. Three years after radiation, a rising PSA was observed over 6 months with PSA level reaching 1.08 ng/mL. He was evaluated with prostate-specific membrane antigen-based (PSMA) F-DCFPyL PET/CT, conventional CT, F-FDG PET/CT, and C-choline PET/CT. The PSMA F-DCFPyL PET/CT successfully targeted oligometastatic prostate cancer, whereas the other imaging studies were not correct in assessing disease extent.
Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection
Authors: David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, Jörg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer
Journal: Immunity (2017)
Bone and mineral disorders in chronic kidney disease: implications for cardiovascular health and ageing in the general population
Authors: Adrian Covic, Marc Vervloet, Ziad A Massy, Pablo Ureña Torres, David Goldsmith, Vincent Brandenburg, Sandro Mazzaferro, Pieter Evenepoel, Jordi Bover, Mugurel Apetrii, Mario Cozzolino
Journal: The Lancet Diabetes & Endocrinology (2017)
Un brote de psitacosis en agentes de aduana belgas
Authors: K De Schrijver
Journal: Eurosurveillance (1995)

En marzo de 1994, las autoridades sanitarias de Amberes, Belgica, fueroninformadas de que un miembro de un equipo de 15 agentes de aduana habiacontraido psitacosis. El agente de aduana en cuestion habia sido hospitalizadocon neumonia 10 dias despues de haber estado en contacto con periquitosimportados ilegalmente por un marinero indio.
Infecciones gastrointestinales en turistas : ¿ de quien es la responsabilidad ?
Authors: R Cartwright
Journal: Eurosurveillance (2004)

Los progresos en la Salud Publica y en el control de las enfermedades transmisibles en Europa fueron posibles no solo gracias a los esfuerzos de los medicos de Salud Publica, sino tambien a un enfoque multidisciplinario. Los resultados del equipo espanol [1] que estudio el brote de gastroenteritis en turistas en la Republica Dominicana son un buen ejemplo de la necesidad de una cooperacion entre disciplinas y entre paises. Al nivel mundial, el turismo forma parte de las tres fuerzas economicas mas importantes, y el numero de turistas va aumentando cada ano. Se han estimado en mas de 70 millones por ano el numero de viajes organizados vendidos en Europa para todos los destinos. Los turistas estan asi expuestos a una gran variedad de ambientes y de organismos patogenos.
a Diversity of Human Hematopoietic Differentiation Programs Identified through In Vivo Tracking of Hematopoiesis in Wiskott-Aldrich Syndrome Patients
Authors: Emmanuelle Six, Laure Caccavelli, Arnaud Lecoules, Christopher L Nobles, France Male, Cécile Roudaut, Clemence Plantier, Alessandra Magnani, Elisa Magrin, Nicolas Cagnard, Anne Galy, Adrian J Thrasher, Salima hacein-Bey Abina, Agathe Guilloux, Isabelle Andre-Schmutz, Charles C. Berry, frederic D. Bushman, Marina Cavazzana
Journal: Blood (2016)
Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas
Authors: Josie Hayes, Yao Yu, Llewellyn E Jalbert, Tali Mazor, Lindsey E Jones, Matthew D Wood, Kyle M Walsh, Henrik Bengtsson, Chibo Hong, Stefan Oberndorfer, Thomas Roetzer, Ivan V Smirnov, Jennifer L Clarke, Manish K Aghi, Susan M Chang, Sarah J Nelson, Adelheid Woehrer, Joanna J Phillips, David A Solomon, Joseph F Costello
Journal: Neuro-Oncology (2017)

Rare multicentric lower-grade gliomas (LGGs) represent a unique opportunity to study the heterogeneity among distinct tumor foci in a single patient and to infer their origins and parallel patterns of evolution. In this study, we integrate clinical features, histology, and immunohistochemistry for 4 patients with multicentric LGG, arising both synchronously and metachronously. For 3 patients we analyze the phylogeny of the lesions using exome sequencing, including one case with a total of 8 samples from the 2 lesions. One patient was diagnosed with multicentric isocitrate dehydrogenase 1 (IDH1) mutated diffuse astrocytomas harboring distinct IDH1 mutations, R132H and R132C; the latter mutation has been associated with Li–Fraumeni syndrome, which was subsequently confirmed in the patient's germline DNA and shown in additional cases with The Cancer Genome Atlas data. In another patient, phylogenetic analysis of synchronously arising grade II and grade III diffuse astrocytomas demonstrated a single shared mutation, IDH1 R132H, and revealed convergent evolution via non-overlapping mutations in ATRX and TP53. In 2 cases, there was divergent evolution of IDH1-mutated and 1p/19q-codeleted oligodendroglioma and IDH1-mutated and 1p/19q-intact diffuse astrocytoma, occurring synchronously in one case and metachronously in a second. Each tumor in multicentric LGG cases may arise independently or may diverge very early in their development, presenting as genetically and histologically distinct tumors. Comprehensive sampling of these lesions can therefore significantly alter diagnosis and management. Additionally, somatic IDH1 R132C mutation in either multicentric or solitary LGG identifies unsuspected germline TP53 mutation, validating the limited number of published cases.
CompositeSearch: A Generalized Network Approach for Composite Gene Families Detection
Authors: Jananan Sylvestre Pathmanathan, Philippe Lopez, François-Joseph Lapointe, Eric Bapteste
Journal: Molecular Biology and Evolution (2017)

Genes evolve by point mutations, but also by shuffling, fusion, and fission of genetic fragments. Therefore, similarity between two sequences can be due to common ancestry producing homology, and/or partial sharing of component fragments. Disentangling these processes is especially challenging in large molecular data sets, because of computational time. In this article, we present CompositeSearch, a memory-efficient, fast, and scalable method to detect composite gene families in large data sets (typically in the range of several million sequences). CompositeSearch generalizes the use of similarity networks to detect composite and component gene families with a greater recall, accuracy, and precision than recent programs (FusedTriplets and MosaicFinder). Moreover, CompositeSearch provides user-friendly quality descriptions regarding the distribution and primary sequence conservation of these gene families allowing critical biological analyses of these data.
Aggiornamento sulle attività e i risultati dell'EARSS
Authors: U Buchholz, S L A M Bronzwaer, P Schrijnemakers, J Monen, J. L. Kool
Journal: Eurosurveillance (2001)

Gli ultimi risultati dell'EARSS (1990–2000) suggeriscono che i tassi di S. aureus meticillino-resistente e di S. pneumoniae non sensibile alla penicillina sono piu alti nei paesi dell'Europa meridionale che in quelli settentrionali. I bambini piccoli, seguiti dagli anziani, sono quelli piu a rischio di infezione da S. pneumoniae non sensibile alla penicillina. Il rischio di essere infettati da S. aureus meticillino-resistente aumenta con l'eta, e sono esposti al rischio maggiore i pazienti ospedalizzati in terapia intensiva.
Identification of Clinical and Biologic Correlates Associated With Outcome in Children With Adrenocortical Tumors Without Germline <i>TP53</i> Mutations: A St Jude Adrenocortical Tumor Registry and Children’s Oncology Group Study
Authors: Emilia Modolo Pinto, Carlos Rodriguez-Galindo, Stanley B. Pounds, Lei Wang, Michael R. Clay, Geoffrey Neale, Elizabeth A.R. Garfinkle, Catherine G. Lam, Carolyn Fein Levy, Alberto S. Pappo, Gerard P. Zambetti, Raul C. Ribeiro
Journal: Journal of Clinical Oncology (2017)

Purpose The clinical features, pathogenesis, and outcomes in children with adrenocortical tumors (ACTs) without germline TP53 mutations have not been systematically studied. Herein, we describe these correlates and analyze their association with outcome. Patients and Methods Genomic DNA was analyzed for TP53, CTNNB1, CDKN1C, ATRX, and chromosome 11p15 abnormalities. β-catenin expression and Ki-67 labeling index (LI) were evaluated by immunostaining. Primary end points were progression-free (PFS) and overall survival. Results Median age of 42 girls and 18 boys was 3.3 years (range, 0.25 to 21.7 years). Complete resection (stages I and II) was achieved in 32 patients, and 28 patients had stage III or IV disease. Constitutional abnormalities of chromosome 11p15 occurred in nine of 40 patients, with six patients not showing phenotype of Beckwith-Wiedemann syndrome. Three-year PFS and overall survival for all patients were 71.4% and 80.5%, respectively. In single-predictor Cox regression analysis, age, disease stage, tumor weight, somatic TP53 mutations, and Ki-67 LI were associated with prognosis. Ki-67 LI and age remained significantly associated with PFS after adjusting for stage and tumor weight. Three-year PFS for 27 patients with Ki-67 LI ≥ 15% was 48.5% compared with 96.2% for 29 patients with Ki-67 LI < 15% (log-rank P = .002), and the rate of relapse increased by 24% with each 1-year increase in age at diagnosis (hazard ratio, 1.24; P = .0057). Conclusion Clinicopathologic features and outcomes of children with ACTs without germline TP53 mutations overlapped those reported for children with germline TP53 mutations. Our findings highlight the central role of genetic or epigenetic alterations on chromosome 11p15 in pediatric ACTs. Ki-67 LI is a strong prognostic indicator and should be investigated to improve the histologic classification of pediatric ACTs.
Recent Advances of Cell-Cycle Inhibitor Therapies for Pediatric Cancer
Authors: Christopher C. Mills, EA. Kolb, Valerie B. Sampson
Journal: Cancer Research (2017)

This review describes the pivotal roles of cell-cycle and checkpoint regulators and discusses development of specific cell-cycle inhibitors for therapeutic use for pediatric cancer. The mechanism of action as well as the safety and tolerability of drugs in pediatric patients, including compounds that target CDK4/CDK6 (palbociclib, ribociclib, and abemaciclib), aurora kinases (AT9283 and MLN8237), Wee1 kinase (MK-1775), KSP (ispinesib), and tubulin (taxanes, vinca alkaloids), are presented. The design of mechanism-based combinations that exploit the cross-talk of signals activated by cell-cycle arrest, as well as pediatric-focused drug development, are critical for the advancement of drugs for rare childhood diseases. Cancer Res; 77(23); 6489-98. ©2017 AACR.
Hepatocellular Carcinoma with Macrovascular Invasion: Defining the Optimal Treatment Strategy
Authors: Charlotte E. Costentin, Cristina R. Ferrone, Ronald S. Arellano, Suvranu Ganguli, Theodore S. Hong, Andrew X. Zhu
Journal: Liver Cancer (2017)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Tumoral macrovascular invasion (MVI) of hepatic and/or portal vein branches is a common phenomenon in hepatocellular carcinoma (HCC) and is associated with poorer prognosis when compared to HCC without MVI. &lt;b&gt;&lt;i&gt;Summary:&lt;/i&gt;&lt;/b&gt; Current international guidelines for the management of HCC recommend sorafenib as the only treatment option in case of MVI. Despite guideline recommendations, several alternative options have been tested to manage HCC with MVI: surgery, transarterial chemoembolization, external or internal radiation, hepatic arterial infusion chemotherapy, percutaneous treatment, cryotherapy, or the combination of two or more of these strategies, with or without sorafenib. Here we will provide a comprehensive state-of-the-art review for the management of this challenging clinical entity based on the most recent available data. &lt;b&gt;&lt;i&gt;Key Messages:&lt;/i&gt;&lt;/b&gt; There is a growing body of evidence suggesting that alternative strategies to standard-of-care sorafenib might improve survival in patients with advanced HCC with MVI but the level of evidence remains weak. Randomized phase III trials are ongoing and will hopefully provide information leading towards a more personalized treatment algorithm.