tbuckley/cabot-search huggingface dataset:
ALBI Score as a Novel Tool in Staging and Treatment Planning for Hepatocellular Carcinoma: Advantage of ALBI Grade for Universal Assessment of Hepatic Function
Authors: Atsushi Hiraoka, Kojiro Michitaka, Takashi Kumada, Masashi Kudo
Journal: Liver Cancer (2017)

Thank you for your interest in our article titled "Albumin-bilirubin (ALBI) grade as part of the evidencebased clinical practice guideline for HCC of the Japan Society of Hepatology: a comparison with the liver damage and Child-Pugh classification" [1] .Huo et al. have sent an important message in their Letter to the Editor .Incorporation of models based on albumin-bilirubin (ALBI)/platelet-albumin-bilirubin (PALBI) grading, calculated using platelet count, serum albumin, and serum total bilirubin, into current HCC staging systems should be considered in order to refine their prognostic accuracy.There is no doubt that a new detailed assessment tool for hepatic function is needed in order to increase predictive accuracy for prognosis.We agree with their proposal.Liu et al. [2] reported that the accuracy of PALBI grade was superior to that of ALBI.It is well known that the prognosis of a patient with HCC depends both on hepatic functional reserve and tumor factors.Thus, in order to address the issues raised by Huo et al., we used modified Japan integrated staging (JIS) scoring, which is calculated based on Child-Pugh classification and tumor node metastasis stage (TNM) of the Liver Cancer Study Group of Japan, 6th edition, as well as ALBI-TNM (ALBI-T) [3] and PALBI-TNM (PALBI-T) to validate the comparison with ALBI and PALBI, after excluding 1 patient whose platelet count was unknown ( n = 3,494).Kaplan-Meyer curves for ALBI-T and PALBI-T are presented in Figure 1 , and they show similar stratification abilities for prognosis.The c-index was the same value as shown in ALBI-T and PALBI-T scoring, while Akaike's information criterion (AIC) for ALBI-T was slightly better than that for PALBI-T ( Table 1 ).When AIC and c-index were assessed for each etiology, PALBI-T was better in HCC patients with the hepatitis C virus (HCV), while ALBI-T was better in those with hepatitis B virus (HBV), as well as those both without HBV and HCV.Thus, the prognostic predictive values may vary slightly for each etiology.HCV and HBV was detected in 64.6 and 14.5%, respectively, of the patients in our cohort, whereas HBV was the most common etiology in the report by Liu et al. [2] .Of note, it cannot be denied that ALBI grade calculated with only 2 factors, albumin and bilirubin, was not inferior to PALBI and presents a simpler tool for assessment of hepatic function.In fact, a good correlation between ALBI and PALBI scores was observed ( r = 0.820, 95% CI: 0.809-0.831,p < 0.0001).Moreover, there
Treatment of sarcoidosis-associated pulmonary hypertension: so close, and yet so far
Authors: Robert P. Baughman, Oksana A. Shlobin
Journal: European Respiratory Journal (2017)

Patients with advanced sarcoidosis may develop pulmonary hypertension for a variety of reasons [1]. One of the earlier papers noting the incidence and severity of this problem came from the clinic run by Gianfranco Rizzato in Milan [2]. Despite the well documented association noted in that article, there were very few reports of sarcoidosis-associated pulmonary hypertension (S-APH) until 20 years later. Over the past 10 years, reports regarding S-APH have come from the USA [3–5], Europe [1, 6, 7] and Japan [8]. These studies found that S-APH was most frequently seen patients with fibrotic disease and was associated with increased mortality [9, 10]. More evidence that sarcoidosis patients with pulmonary hypertension respond to therapy <http://ow.ly/H40c30fetN4>
Out of Southern East Asia of the Brown Rat Revealed by Large-Scale Genome Sequencing
Authors: Lin Zeng, Chen Ming, Yan Li, Ling-Yan Su, Yan-Hua Su, Newton O Otecko, Ambroise Dalecky, Stephen Donnellan, Ken Aplin, Xiao-Hui Liu, Ying Song, Zhi-Bin Zhang, Ali Esmailizadeh, Saeed S Sohrabi, Hojjat Asadollahpour Nanaei, He-Qun Liu, Ming-Shan Wang, Solimane Ag Atteynine, Gérard Rocamora, Fabrice Brescia, Serge Morand, David M Irwin, Ming-Sheng Peng, Yong-Gang Yao, Hai-Peng Li, Dong-Dong Wu, Ya-Ping Zhang
Journal: Molecular Biology and Evolution (2017)

The geographic origin and migration of the brown rat (Rattus norvegicus) remain subjects of considerable debate. In this study, we sequenced whole genomes of 110 wild brown rats with a diverse world-wide representation. We reveal that brown rats migrated out of southern East Asia, rather than northern Asia as formerly suggested, into the Middle East and then to Europe and Africa, thousands of years ago. Comparison of genomes from different geographical populations reveals that many genes involved in the immune system experienced positive selection in the wild brown rat.
Infecciones entéricas por salmonelas en Guipúzcoa, España, 1983-2000
Authors: J. M Marimon, E Pérez-Trallero, M. Gomariz, C. Rodríguez-Andres, C. López-Lopategui
Journal: Eurosurveillance (2003)

La incidencia de la infeccion enterica por Salmonella en Guipuzcoa, Espana, se estimo mediante un estudio de la poblacion estable entre 1983 y 2000. Solo se incluyeron casos confirmados por cultivo de heces. La tasa media anual de infeccion en ninos menores de 2 anos fue de 1.121 por 100.000 habitantes (IC 95%; 1060-1181). Este grupo de edad presentaba el mayor riesgo relativo (RR), 16,2 veces mas elevado que el RR de los mayores de 14 anos. Salmonella Enteritidis fue el serotipo predominante (80,4% de todos los pacientes), seguida de Salmonella Typhimurium (11,7%).
Impact of Early Discharge After Coronary Artery Bypass Graft Surgery on Rates of Hospital Readmission and Death fn1fn1This study was supported by Research Grants HS-06503 and HS-08805-02 from the Agency for Health Care Policy and Research, Rockville, Maryland and was presented in part at the 45th Annual Scientific Session of the American College of Cardiology, Orlando, Florida, March 1996.
Authors: Patricia A. Cowper, Eric D. Peterson, Elizabeth R. DeLong, James G. Jollis, Lawrence H. Muhlbaier, Daniel B. Mark
Journal: Journal of the American College of Cardiology (1997)
<i>Notes from the Field</i>: Postexposure Prophylaxis for Rabies After Consumption of a Prepackaged Salad Containing a Bat Carcass — Florida, 2017
Authors: Vikram Krishnasamy, Matthew R. Mauldin, Matthew E. Wise, Ryan Wallace, Laura Whitlock, Colin Basler, Clint Morgan, Dana Grissom, Sherry Worley, Danielle Stanek, Jamie DeMent, Pamela Yager, William Carson, Rene E. Condori, Yoshinori Nakazawa, Claire Walker, Yu Li, Christopher Wynens, Allison Wellman, James Ellison, Emily Pieracci
Journal: MMWR Morbidity and Mortality Weekly Report (2017)
TCT-497 Novel Risk Tool to Predict Angina-Related Health Status following Percutaneous Coronary Intervention of a Chronic Total Occlusion: A Sub-analysis of the OPEN CTO Registry
Authors: Eric Secemsky, J. Aaron Grantham, John Spertus, David Cohen, Philip Jones, Adam Salisbury, Suzanne Arnold, Frank Harrell, William Lombardi, Dimitrios Karmpaliotis, Jeffrey Moses, James Sapontis, Robert Yeh
Journal: Journal of the American College of Cardiology (2017)
TCT-635 Impact of stent thrombosis and non-stent-related re-infarction in patients with previous ST-segment elevation myocardial infarction
Authors: Mariusz Tomaniak, Dominika Klimczak, Maria Tovar, Marcella De Paolis, Joost Daemen, Jeroen Wilschut, Peter de Jaegere, Felix Zijlstra, Nicolas Van Mieghem, Roberto Diletti
Journal: Journal of the American College of Cardiology (2017)
Expression of Proliferating Cell Nuclear Antigen and Deoxyribonucleic Acid Value in Renal Cell Carcinoma: Correlation with Different Histopathological Parameters and Patient Survival
Authors: Isteaq Ahmed Shameem, Tomoyuki Shimabukuro, Takashi Wada, Hiroaki Kurisu, Katsusuke Naito
Journal: European Urology (1996)
P2.05-047 Feasibility Study: Assessment of RT Dose Using Cardiac MRI Contouring Methodology on Retrospective Lung Planning CT Scans
Authors: Nazia Mohammed, Martin Glegg, Colin Berry, Naveed Sattar, Claire Lawless, Jim Paul, Jon Stobo, Kenneth Mangion, Noelle O'Rourke, Marimuthu Sankaralingam
Journal: Journal of Thoracic Oncology (2017)
Rubéola en Dinamarca
Authors: S Glismann
Journal: Eurosurveillance (2004)

Un promedio de 20.000 casos de rubeola se declaro anualmente en Dinamarca hasta 1987. Sin embargo, en 1989 solo se declararon 1.006 casos y se desconoce la incidencia actual real de infeccion por rubeola en Dinamarca aunque se considera muy baja y l1 por 100.000 habitantes. La reduccion importante de la incidencia de la rubeola refleja el exito de la vacunacion, iniciada en Dinamarca en 1980, de mujeres seronegativas para rubeola en edad fertil. A partir de 1982, el programa de seguridad sanitaria tambien destino fondos a la vacunacion de ninos y en 1987 se introdujo el programa de vacunacion infantil danes. La baja incidencia es sostenible gracias a estas intervenciones y, desde 1984, el sindrome de rubeola congenita y la rubeola durante el embarazo son enfermedades infecciosas de declaracion obligatoria en Dinamarca. No obstante, para conseguir el objetivo de la OMS de controlar la rubeola en la Region, se esta estudiando introducir la declaracion obligatoria de todos los casos de rubeola diagnosticados microbiologicamente.
Somatic DNA mutations, MSI status, mutational load (ML): Association with overall survival (OS) in patients (pts) with metastatic colorectal cancer (mCRC) of CALGB/SWOG 80405 (Alliance).
Authors: Federico Innocenti, Fang-Shu Ou, Tyler Zemla, Donna Niedzwiecki, Xueping Qu, Rachel Tam, Shilpi Mahajan, Richard M. Goldberg, Robert J. Mayer, Monica M. Bertagnolli, Hanna Kelly Sanoff, Howard S. Hochster, Charles David Blanke, Alan P. Venook, Heinz-Josef Lenz, Omar Kabbarah
Journal: Journal of Clinical Oncology (2017)

3504 Background: CALGB 80405 was a randomized phase III trial that found no difference in OS in first-line mCRC pts treated with either bevacizumab (Bev) or cetuximab (Cet). Primary tumor DNA from 361 pts, including KRAS mutant (mut) pts, has been profiled for somatic gene mutations/ML/MSI to discover molecular markers of OS. Methods: Mutations in 11 genes were determined by PCR, MSI by microsatellite analysis, and ML by next-generation sequencing (FoundationOne). Cox proportional hazard models are used, stratified by prior XRT and +/- adjuvant chemotherapy; adjusted by age, race, gender, synchronous vs. metachronous, liver metastases, sidedness, all RAS. Results: BRAF: Mut pts had shorter OS than wild-type (wt) pts (HR 1.92, 95% CI 1.34,2.75; p&lt;0.001); HR 1.65 (1.09,2.50) after adjusting for sidedness (p 0.022). In mut pts longer OS is observed in Bev arm vs. Cet arm (p 0.041); in wt pts no arm difference is observed (p 0.291, table). MSI: OS does not differ between MSI-H and MSI-S pts (HR 0.78 [0.40, 1.52], p 0.450). In MSI-H pts longer OS is observed in Bev arm vs. Cet arm (p 0.002); in MSI-S pts no difference is observed (p 0.305, table). ML: Hypermutated MSI-H pts are excluded. In a subset of 205 pts, pts with ML&gt;5 (N=93) have longer OS than pts with ML≤5 (N=112) (HR 0.65 [0.42,1.00], p 0.048). In Bev arm higher ML confers longer OS than lower ML (HR 0.85 [0.80,0.96], p 0.004); in Cet arm no difference is observed (HR 0.99 [0.90,1.09], p 0.862). Conclusions: BRAF is a strong negative prognostic factor in mCRC, even when sidedness is taken into account. ML is a novel marker for further evaluation. The effect of Bev and Cet in either BRAF mut or MSI-H pts should be tested in larger datasets. Updated results from more screened samples will be presented. [Table: see text]
Abstract 14964: A Novel Caveolin-3 Mutation Identified in a Patient With Profound Drug-Induced QT Prolongation and Sudden Cardiac Arrest Results in Dysfunction of Multiple Ion Channels Responsible for Cardiac Action Potential Duration
Authors: Dan Ye, Wei Zhou, David J Tester, Michael J Ackerman
Journal: Circulation (2016)

Introduction:  Caveolin-3 (CAV3) is an essential scaffolding protein for caveolae formation in cardiomyocytes and targets multiple long QT syndrome (LQTS)-associated ion channels including the cardiac sodium channel (Nav1.5, LQT3), L-type calcium channel (Cav1.2, LQT8), and the voltage-gated potassium channels, Kv7.1 (LQT1) and Kv11.1 (LQT2), to the cell surface membrane. Mutations in  CAV3  have been linked to LQTS (LQT9) by causing an LQT3-like accentuation in late sodium current. Here, we characterize a novel CAV3-V37L mutation by heterologous co-expression with the 4 major LQTS-related ion channels.   Methods:  The proband was a 39-year-old female with drug-induced, in-hospital sudden cardiac arrest (SCA) with documented profound QT prolongation (QTc > 600 ms) and torsades. Her QTc after removal of all offending drugs was 500 ms. LQTS genetic testing revealed a rare CAV3-V37L mutation and the common Kv11.1-K897T polymorphism. The CAV3-V37L and Kv11.1-K897T variants were engineered using site-directed mutagenesis. Standard whole-cell patch clamp technique was used to measure Nav1.5, Cav1.2, Kv7.1, and Kv11.1 currents when heterologously co-expressed with either CAV3-WT or CAV3-V37L in TSA201 cells.   Results:  Surprisingly, Nav1.5 channel function was not disrupted by CAV3-V37L. Instead, Cav1.2 channels co-expressed with CAV3-V37L had slower inactivation and a 1.4 fold increase in late current at +10 mV compared to CAV3-WT (p   Conclusions:  Studies identified the underlying mechanisms of QT prolongation and SCA in a patient with a novel CAV3 mutation. Rather than altered Nav1.5 function, the CAV-V37L mutation precipitated a gain-of-function of Cav1.2 and a loss-of-function of both Kv7.1 and Kv11.1. K897T displayed a modifying effect on the electrophysiological phenotype of Kv11.1 when co-expressed with CAV-V37L.
TCT-436 Technical safety and feasibility of coronary interventions in patients with prior self-expanding transcatheter aortic valve replacement
Authors: Akihito Tanaka, Richard Jabbour, Marianna Adamo, Giuseppe Bruschi, Anna Sonia Petronio, Marco Barbanti, Corrado Tamburino, Bernhard Reimers, Antonio Colombo, Azeem Latib
Journal: Journal of the American College of Cardiology (2017)
TCT-829 Long-term Outcomes of Final Kissing Balloon Technique After Crossover Stenting for Left Main Coronary Artery in Patients with and without True Bifurcation: From the AOI-LMCA registry
Authors: Koji Nishida, Mamoru Toyofuku, Daisuke Furukawa, Hirooki Higami, Masanobu Ohya, Yasushi Fuku, Kyohei Yamaji, Hiromi Muranishi, Yuhei Yamaji, Tomohisa Tada, Euihong Ko, Kenji Ando, Kazushige Kadota, Hiroki Sakamoto, Takashi Tamura, Kazuya Kawai, Takeshi Morimoto, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2017)
Copertura della vaccinazione contro l'influenza nelle persone anziane, Campania (Italia), 1999
Authors: P D'Argenio, B Adamo, R Coluccio, A D'Apice, M. A. Ferrara, F Giugliano, R Parrella, F Peluso, V Romeo, C Ronga, A Simonetti, A Citarella
Journal: Eurosurveillance (2001)

Da uno studio sulla copertura vaccinale contro l'influenza tra gli anziani, e risultato che il 56% degli intervistati era stato vaccinato (copertura pesata 50%), rispetto all'obiettivo del 75%. Tassi piu elevati sono stati riscontrati negli anziani con piu di 74 anni e in quelli affetti da malattie croniche
TCT-286 Contemporary Outcomes of Isolated Bioprothestic Mitral Valve Replacement: A Benchmark for Transcatheter Mitral Valve Replacement
Authors: Fahad Alqahtani, Sami Aljohani, Tatiana Busu, Ahmad Almustafa, Akram Kawsara, Mohamad Alkhouli
Journal: Journal of the American College of Cardiology (2017)
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract
Authors: Amelie T. van der Ven, Asaf Vivante, Friedhelm Hildebrandt
Journal: Journal of the American Society of Nephrology (2017)

Congenital anomalies of the kidneys and urinary tract (CAKUT) comprise a large spectrum of congenital malformations ranging from severe manifestations, such as renal agenesis, to potentially milder conditions, such as vesicoureteral reflux. CAKUT causes approximately 40% of ESRD that manifests within the first three decades of life. Several lines of evidence indicate that CAKUT is often caused by recessive or dominant mutations in single (monogenic) genes. To date, approximately 40 monogenic genes are known to cause CAKUT if mutated, explaining 5%–20% of patients. However, hundreds of different monogenic CAKUT genes probably exist. The discovery of novel CAKUT-causing genes remains challenging because of this pronounced heterogeneity, variable expressivity, and incomplete penetrance. We here give an overview of known genetic causes for human CAKUT and shed light on distinct renal morphogenetic pathways that were identified as relevant for CAKUT in mice and humans.
Abstract 13869: The Usefulness of Echocardiographic Indices of Right Ventricular Systolic Function in Patients With Interstitial Pneumonia
Authors: Masashi Amano, Chisato Izumi, Yuki Obayashi, Masayuki Fuki, Miyako Imanaka, Shunsuke Nishimura, Maiko Kuroda, Sari Imamura, Naoaki Onishi, Jiro Sakamoto, Yodo Tamaki, Soichiro Enomoto, Makoto Miyake, Toshihiro Tamura, Hirokazu Kondo, Kazuaki Kaitani, Yoshihisa Nakagawa
Journal: Circulation (2016)

Introductions: It is well known that interstitial pneumonia (IP) may induce pulmonary hypertension, but there have been few studies about right ventricular (RV) function in patients with IP and usefulness of echocardiographic indices in its evaluation. Methods: We retrospectively investigated 200 consecutive patients with IP. Patients with left heart failure or emphysema were excluded. Conventional left ventricular (LV) parameters and indices of RV function, such as tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and longitudinal strain of right ventricular free wall (RVLS) were evaluated. As a substitute for pulmonary vascular resistance, pressure gradient calculated by peak velocity of tricuspid regurgitation (TRPG) / cardiac output (CO) was used. Stage of IP was classified as mild, moderate, and severe, based on the degree of fibrosis and involvement area with CT images. Results: The mean age was 70.5±8.7 years (122 males (61%)). Stage of IP was graded as mild in 96 patients (48%), moderate in 71 patients (35.5%), and severe in 33 patients (16.5%). All LV parameters were normal at all stages of IP. FAC, which is an index of transverse RV systolic function, has not decreased until IP became severe (42.4±7.9 at mild vs. 40.7±7.5 at moderate vs. 32.7±7.1% at severe stage). On the other hand, TAPSE and RVLS, which are indices of longitudinal RV systolic function, showed graded reduction as stage of IP progressed (TAPSE: 21.1±3.0 vs. 18.0±3.3 vs. 15.2±3.2 mm; p&lt;0.01, RVLS: -20.2±4.2 vs. -18.3±5.0 vs. -15.1±3.9%; p&lt;0.01) and these indices have decreased at earlier stage of IP although TRPG and TRPG/CO were not elevated at this stage. (TRPG: 22.5±3.9 vs. 28.2±10.0mmHg, TRPG/CO: 5.0±1.7 vs. 6.1±2.1; mild vs. moderate). In ROC analysis, TAPSE (AUC=0.82) showed high predictive value for distinguishing between mild and moderate /severe IP, and the optimal cut-off values were 18.4mm (sensitivity: 80.0%, specificity: 70.2%). Conclusion: RV dysfunction progressed as stage of IP progressed. TAPSE and RVLS as the indices of longitudinal RV systolic function are useful to detect the earlier stage of RV dysfunction in patients with IP.
SlicerDMRI: Open Source Diffusion MRI Software for Brain Cancer Research
Authors: Isaiah Norton, Walid Ibn Essayed, Fan Zhang, Sonia Pujol, Alex Yarmarkovich, Alexandra J. Golby, Gordon Kindlmann, Demian Wassermann, Raul San Jose Estepar, Yogesh Rathi, Steve Pieper, Ron Kikinis, Hans J. Johnson, Carl-Fredrik Westin, Lauren J. O'Donnell
Journal: Cancer Research (2017)

Abstract Diffusion MRI (dMRI) is the only noninvasive method for mapping white matter connections in the brain. We describe SlicerDMRI, a software suite that enables visualization and analysis of dMRI for neuroscientific studies and patient-specific anatomic assessment. SlicerDMRI has been successfully applied in multiple studies of the human brain in health and disease, and here, we especially focus on its cancer research applications. As an extension module of the 3D Slicer medical image computing platform, the SlicerDMRI suite enables dMRI analysis in a clinically relevant multimodal imaging workflow. Core SlicerDMRI functionality includes diffusion tensor estimation, white matter tractography with single and multi-fiber models, and dMRI quantification. SlicerDMRI supports clinical DICOM and research file formats, is open-source and cross-platform, and can be installed as an extension to 3D Slicer (www.slicer.org). More information, videos, tutorials, and sample data are available at dmri.slicer.org. Cancer Res; 77(21); e101–3. ©2017 AACR.
OA02.03 Potential Predictors of Pembrolizumab Associated Pneumonitis: A Retrospective Review of the HCRN LUN 14-179 Trial
Authors: S.S. Ahmed, G.A. Durm, J. Donatelli, Y. Liu, H. Yao, C. Desrosiers, Z. Liu, F.M. Kong, N. Hanna
Journal: Journal of Thoracic Oncology (2017)
Next generation of anti-inflammatory therapy for COPD?
Authors: Henrik Watz
Journal: European Respiratory Journal (2017)

Symptomatic treatment of chronic obstructive pulmonary disease (COPD) by next-generation bronchodilators has improved considerably over the past decade: Long-acting beta-agonists and long-acting muscarinic antagonists (also as combined fixed-dose inhalation) are now available for long-term maintenance. However, there has been very little progress in developing anti-inflammatory drugs that specifically target inflammation in COPD [1]. More than 10 years ago, several inflammatory pathways and potential drugs in early-phase development for COPD were summarised in two well-known review articles [2, 3]. However, of the drug candidates listed there, only the oral phosphodiesterase-4 inhibitor roflumilast made it to regulatory approval; its anti-inflammatory effects resulted in a reduction of exacerbations and modest improvements in lung function [1, 4]. Other drugs either failed to show a clear benefit, or drug development was stopped because of safety concerns [5]. This has made the past decade disappointing for the development of novel anti-inflammatory therapies in COPD [1]. The MAPK inhibitor RV568 might be the next generation of anti-inflammatory therapy for COPD <http://ow.ly/vccD30fNP3c> The author thanks Mary McKenney for careful review of the manuscript.