tbuckley/cabot-search huggingface dataset:
Mitotic figure in the peripheral blood smear
Authors: Sebastian Hörber, Ingo Rettig, Andreas Peter
Journal: American Journal of Hematology (2017)

A previously healthy 19-year-old man presented with fever, sore throat, and strong feeling of illness. Physical examination showed strong swelling of throat tonsils and moderate hepatosplenomegaly. The laboratory values were as follows: a total white blood count of 10.9 × 109/L, hemoglobin 14.1 g/dL, and a platelet count of 109 × 109/L. Total bilirubin was 1.4 mg/dL and CRP was 1.32 mg/dL. The serological analyses revealed IgG and IgM antibodies against EBV-VCA consistent with an acute Epstein–Barr virus infection. The peripheral blood smear revealed 80.0% lymphocytes, 12.4% neutrophils, 6.9% monocytes, 0.4% eosinophils, and 0.3% basophils. In it a mitotic figure was found (see Image 1). Mitotic figures are an extremely uncommon finding as they are usually seen in patients with acute leukemia or rarer in EBV infections. Symptomatic therapy led to complete resolution of the symptoms. Nothing to report.
The influence of discrepant imaging judgements on the classification of axial spondyloarthritis is limited: a replication in the SpondyloArthritis Caught Early (SPACE) cohort
Authors: Zineb Ez-Zaitouni, Miranda van Lunteren, Pauline A C Bakker, Rosaline van den Berg, Monique Reijnierse, Karen Minde Fagerli, Robert B M Landewé, Roberta Ramonda, Lennart T H Jacobsson, Floris A van Gaalen, Désirée van der Heijde
Journal: Annals of the Rheumatic Diseases (2017)

Sacroiliitis on imaging is important in the diagnosis and classification of patients with axial spondyloarthritis (axSpA). In the Assessment of SpondyloArthritis International Society (ASAS) classification criteria for axSpA, sacroiliitis is defined as either radiographic sacroiliitis (X-SI) according to the modified New York (mNY) criteria or active inflammation on MRI sacroiliac joints (MRI-SI) highly suggestive of axSpA (ASAS definition).1–4 According to the ASAS criteria, patients with chronic back pain are classified via the imaging arm when sacroiliitis on MRI-SI or X-SI plus ≥1 spondyloarthritis (SpA) feature is present, or via the clinical arm where ≥2 SpA features in addition to Human Leukocyte Antigen B27 (HLA-B27) have to be present.

While local clinicians can interpret imaging of the sacroiliac joints in the context of clinical information, central readers of research studies …
A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study
Authors: B. Risslegger, T. Zoran, M. Lackner, M. Aigner, F. Sánchez-Reus, A. Rezusta, A. Chowdhary, S.J. Taj-Aldeen, M.C. Arendrup, S. Oliveri, D.P. Kontoyiannis, A. Alastruey-Izquierdo, K. Lagrou, G. Lo Cascio, J.F. Meis, W. Buzina, C. Farina, M. Drogari-Apiranthitou, A. Grancini, A.M. Tortorano, B. Willinger, A. Hamprecht, E. Johnson, L. Klingspor, V. Arsic-Arsenijevic, O.A. Cornely, J. Meletiadis, W. Prammer, V. Tullio, J.-J. Vehreschild, L. Trovato, R.E. Lewis, E. Segal, P.-M. Rath, P. Hamal, M. Rodriguez-Iglesias, E. Roilides, S. Arikan-Akdagli, A. Chakrabarti, A.L. Colombo, M.S. Fernández, M.T. Martin-Gomez, H. Badali, G. Petrikkos, N. Klimko, S.M. Heimann, J. Houbraken, O. Uzun, M. Edlinger, S. de la Fuente, C. Lass-Flörl
Journal: Clinical Microbiology and Infection (2017)
Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis
Authors: Lei Zhang, Meizhen Cai, Zhicheng Gong, Bingchang Zhang, Yuanpei Li, Li Guan, Xiaonan Hou, Qing Li, Gang Liu, Zengfu Xue, Muh-hua Yang, Jing Ye, Y. Eugene Chin, Han You
Journal: Journal of Clinical Investigation (2017)

Geminin expression is essential for embryonic development and the maintenance of chromosomal integrity. In spite of this protective role, geminin is also frequently overexpressed in human cancers and the molecular mechanisms underlying its role in tumor progression remain unclear. The histone deacetylase HDAC3 modulates transcription factors to activate or suppress transcription. Little is known about how HDAC3 specifies substrates for modulation among highly homologous transcription factor family members. Here, we have demonstrated that geminin selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3, thereby specifically facilitating FoxO3 deacetylation. We determined that geminin-associated HDAC3 deacetylates FoxO3 to block its transcriptional activity, leading to downregulation of the downstream FoxO3 target Dicer, an RNase that suppresses metastasis. Breast cancer cells depleted of geminin or HDAC3 exhibited poor metastatic potential that was attributed to reduced suppression of the FoxO3-Dicer axis. Moreover, elevated levels of geminin, HDAC3, or both together with decreased FoxO3 acetylation and reduced Dicer expression were detected in aggressive human breast cancer specimens. These results underscore a prominent role for geminin in promoting breast cancer metastasis via the enzyme-substrate-coupling mechanism in HDAC3-FoxO3 complex formation.
Changes in France’s Deferral of Blood Donation by Men Who Have Sex with Men
Authors: Pierre Tiberghien, Josiane Pillonel, François Toujas, Benoit Vallet
Journal: New England Journal of Medicine (2017)

Since July 2016 in France, blood donations from men who have had sex with men (MSM) in the previous year have been banned. To evaluate a shorter waiting period, data are being collected on retesting MSM who have had sex with only one partner in the previous 4 months.
TCTAP A-146 A Novel Abluminal Coated Sirolimus-eluting Stent as a Treatment Option for Diabetic Patients: Results from an All-comers Multicenter Study
Authors: Luca Testa, Sameer Dani, Nirav Bhalani, Arvind Sharma, Chirag Sheth, Prathapkumar Natarajapillai, Apurva Vasavada, Jayachandran Thejus, Pritesh Parekh, Kamal Sharma, Rutvik Trivedi
Journal: Journal of the American College of Cardiology (2017)
TCTAP A-005 A Hybrid Strategy with Bioresorbable Vascular Scaffolds and Drug Eluting Stents for Treating Complex Coronary Lesions
Authors: Alfonso Ielasi, Richard Jabbour, Akihito Tanaka, Massimo Leoncini, Bernardo Cortese, Giulietta Grigis, Damiano Regazzoli, Maurizio Tespili, Azeem Latib, Antonio Colombo
Journal: Journal of the American College of Cardiology (2017)
Ritonavir-boosted darunavir combined with raltegravir or tenofovir-emtricitabine in antiretroviral-naive adults infected with HIV-1: 96 week results from the NEAT001/ANRS143 randomised non-inferiority trial.
Authors: François Raffi, Abdel G Babiker, Laura Richert, Jean-Michel Molina, Elizabeth C George, Andrea Antinori, Jose R Arribas, Jesper Grarup, Fleur Hudson, Christine Schwimmer, Juliette Saillard, Cédrick Wallet, Per O Jansson, Clotilde Allavena, Remko Van Leeuwen, Jean-François Delfraissy, Stefano Vella, Geneviève Chêne, Anton Pozniak
Journal: The Lancet Neurology (2014)
Asymptomatic Microscopic Hematuria—Rethinking the Diagnostic Algorithm
Authors: Leslee L. Subak, Deborah Grady
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Social determinants of infectious diseases: a public health priority
Authors: J C Semenza, J E Suk, S Tsolova
Journal: Eurosurveillance (2010)

Preview this article: Social determinants of infectious diseases: a public health priority, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/27/art19608-en-1.gif
SAR650984: A Potent Anti-CD38 Therapeutic Antibody with Three Mechanisms of Action (Apoptosis, ADCC, CDC) for Hematological Malignancies
Authors: Peter U. Park, Véronique Blanc, Jutta Deckert, Pascale Lejeune, Laura M. Bartle, Anna Skaletskaya, Michele F. Mayo, Chonghui Zhang, Marie-Cécile Wetzel, Daniel J. Tavares, Robert J. Lutz, Thomas Chittenden, Marie-Christine Bissery, John M. Lambert, Victor S. Goldmacher
Journal: Blood (2008)
Comparison of dynamic monitoring strategies based on CD4 cell counts in virally suppressed, HIV-positive individuals on combination antiretroviral therapy in high-income countries: a prospective, observational study
Authors: Ellen C Caniglia, Lauren E Cain, Caroline A Sabin, James M Robins, Roger Logan, Sophie Abgrall, Michael J Mugavero, Sonia Hernández-Díaz, Laurence Meyer, Remonie Seng, Daniel R Drozd, George R Seage, Fabrice Bonnet, Francois Dabis, Richard D Moore, Peter Reiss, Ard van Sighem, William C Mathews, Julia del Amo, Santiago Moreno, Steven G Deeks, Roberto Muga, Stephen L Boswell, Elena Ferrer, Joseph J Eron, Sonia Napravnik, Sophie Jose, Andrew Phillips, Amy C Justice, Janet P Tate, John Gill, Antonio Pacheco, Valdilea G Veloso, Heiner C Bucher, Matthias Egger, Hansjakob Furrer, Kholoud Porter, Giota Touloumi, Heidi Crane, Jose M Miro, Jonathan A Sterne, Dominique Costagliola, Michael Saag, Miguel A Hernán
Journal: The Lancet HIV (2017)
A Complex Phenomenon in Complex Adaptive Health Care Systems—Alarm Fatigue
Authors: Azizeh Khaled Sowan, Charles Calhoun Reed
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration
Authors: Yuju Li, Justin Peer, Runze Zhao, Yinghua Xu, Beiqing Wu, Yi Wang, Changhai Tian, Yunlong Huang, Jialin Zheng
Journal: Translational Neurodegeneration (2017)

Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses, executing important physiological functions in the central nervous system. There are two isoforms of glutaminase 1, KGA and GAC, both of which are generated through alternative splicing from the same gene. KGA and GAC both transcribe 1–14 exons in the N-terminal, but each has its unique C-terminal in the coding sequence. We have previously identified that KGA and GAC are differentially regulated during inflammatory stimulation and HIV infection. Furthermore, glutaminase 1 has been linked to brain diseases such as amyotrophic lateral sclerosis, Alzheimer's disease, and hepatic encephalopathy. Core enzyme structure of KGA and GAC has been published recently. However, how other coding sequences affect their functional enzyme activity remains unclear. We cloned and performed serial deletions of human full-length KGA and GAC from the N-terminal and the C-terminal at an interval of approximately 100 amino acids (AAs). Prokaryotic expressions of the mutant glutaminase 1 protein and a glutaminase enzyme activity assay were used to determine if KGA and GAC have similar efficiency and efficacy to convert glutamine into glutamate. When 110 AAs or 218 AAs were deleted from the N-terminal or when the unique portions of KGA and GAC that are beyond the 550 AA were deleted from the C-terminal, KGA and GAC retained enzyme activity comparable to the full length proteins. In contrast, deletion of 310 AAs or more from N-terminal or deletion of 450 AAs or more from C-terminal resulted in complete loss of enzyme activity for KGA/GAC. Consistently, when both N- and C-terminal of the KGA and GAC were removed, creating a truncated protein that expressed the central 219 AA - 550 AA, the protein retained enzyme activity. Furthermore, expression of the core 219 AA - 550 AA coding sequence in cells increased extracellular glutamate concentrations to levels comparable to those of full-length KGA and GAC expressions, suggesting that the core enzyme activity of the protein lies within the central 219 AA - 550 AA. Full-length KGA and GAC retained enzyme activities when kept at 4 °C. In contrast, 219 AA - 550 AA truncated protein lost glutaminase activities more readily compared with full-length KGA and GAC, suggesting that the N-terminal and C-terminal coding regions are required for the stability KGA and GAC. Glutaminase isoforms KGA and GAC have similar efficacy to catalyze the conversion of glutamine to glutamate. The core enzyme activity of glutaminase 1 protein is within the central 219 AA - 550 AA. The N-terminal and C-terminal coding regions of KGA and GAC help maintain the long-term activities of the enzymes.
Erratum: The contribution of transcription factor IRF1 to the interferon-γ-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells (Nature Immunology (2008) vol. 9 (34-41) 10.1038/ni1538)
Authors: Shin Ichi Kano, Sato Kojiro, Yasuyuki Morishita, Sabine Vollstedt, Sunhwa Kim, Keith Bishop, Kenya Honda, Masato Kubo, Tadatsugu Taniguchi
Journal: Nature Immunology (2008)
Physicians, Firearms, and Free Speech — Overturning Florida’s Firearm-Safety Gag Rule
Authors: Wendy E. Parmet, Jason A. Smith, Matthew Miller
Journal: New England Journal of Medicine (2017)

A U.S. appeals court has invalidated parts of Florida’s Firearm Owners’ Privacy Act and affirmed that the First Amendment applies to speech between physicians and patients, ensuring that doctors may continue making efforts to protect patients from gun-related injuries.
Plasma ctDNA Analysis for Detection of the EGFR T790M Mutation in Patients with Advanced Non–Small Cell Lung Cancer
Authors: Suzanne Jenkins, James C-H. Yang, Suresh S. Ramalingam, Karen Yu, Sabina Patel, Susie Weston, Rachel Hodge, Mireille Cantarini, Pasi A. Jänne, Tetsuya Mitsudomi, Glenwood D. Goss
Journal: Journal of Thoracic Oncology (2017)
Bradycardia in a Child After Using Brimonidine as Toothpaste
Authors: Abby J. Montague, Stacey Bangh, Jon B. Cole
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Sulfonylureas and the Risks of Cardiovascular Events and Death: A Methodological Meta-Regression Analysis of the Observational Studies
Authors: Laurent Azoulay, Samy Suissa
Journal: Diabetes Care (2017)

Recent randomized trials have compared the newer antidiabetic agents to treatments involving sulfonylureas, drugs associated with increased cardiovascular risks and mortality in some observational studies with conflicting results. We reviewed the methodology of these observational studies by searching MEDLINE from inception to December 2015 for all studies of the association between sulfonylureas and cardiovascular events or mortality. Each study was appraised with respect to the comparator, the outcome, and study design–related sources of bias. A meta-regression analysis was used to evaluate heterogeneity. A total of 19 studies were identified, of which six had no major design-related biases. Sulfonylureas were associated with an increased risk of cardiovascular events and mortality in five of these studies (relative risks 1.16–1.55). Overall, the 19 studies resulted in 36 relative risks as some studies assessed multiple outcomes or comparators. Of the 36 analyses, metformin was the comparator in 27 (75%) and death was the outcome in 24 (67%). The relative risk was higher by 13% when the comparator was metformin, by 20% when death was the outcome, and by 7% when the studies had design-related biases. The lowest predicted relative risk was for studies with no major bias, comparator other than metformin, and cardiovascular outcome (1.06 [95% CI 0.92–1.23]), whereas the highest was for studies with bias, metformin comparator, and mortality outcome (1.53 [95% CI 1.43–1.65]). In summary, sulfonylureas were associated with an increased risk of cardiovascular events and mortality in the majority of studies with no major design-related biases. Among studies with important biases, the association varied significantly with respect to the comparator, the outcome, and the type of bias. With the introduction of new antidiabetic drugs, the use of appropriate design and analytical tools will provide their more accurate cardiovascular safety assessment in the real-world setting.
Incidence of Mental Disorder
Journal: BMJ (1940)

the convention of the Eastern Regional Conference of the Canon Law Society of America, we read a paper entitled, "Essential Incompatibility as Grounds for Nullity of Marriage."' The thesis was based on well known canonical principles.No one could oblige himself or be obliged to do the impossible.The impossibility could be rooted in the psychic as well as in the physical.Permanence is an essential property of marriage.To these principles we added that to exchange permanent rights with each other, husband and wife must be able to lead some "common life" together.They must at least be able to lead the minimum conjugal life together, i.e. to engage in marital intercourse in a truly human fashion.Later Ann6, in a celebrated Rotal Decision, published November 10, 1970 (but decided on February 25, 1969) spoke of a basic capacity for the community of conjugal life as being necessary for a valid marriage contract. 2 In the paper on essential incompatibility we spoke of a "constitutional incapacity," signifying an inability based radically in the structure of the personality, not so much in the genes as in the environmental development of the personality.We concluded that two persons, relative to each other, could be so constituted in their personalities, that they were psychically incapable of leading a common life together.We pre-
TCTAP C-257 Retrograde Recanalization of Chronic Total Occlusion of Superficial Femoral Artery After Antegrade Dissection
Authors: Nai-Yu Chi, Chun-Yuan Chu, Po-Chao Hsu, Cheng-An Chiu, Ho-Ming Su, Wen-Chol Voon, Heueh-Wei Yen, Wen-Ter Lai
Journal: Journal of the American College of Cardiology (2017)
Performing Percutaneous Coronary Intervention Without On-site Cardiac Surgery Is Not a License for Percutaneous Coronary Intervention Instead of Coronary Artery Bypass Grafting
Authors: Faisal G. Bakaeen, Eugene H. Blackstone, Lars G. Svensson
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal