tbuckley/cabot-search huggingface dataset:
SAT0676 (SERONEGATIVE) males show better eular treatment response than females in newly diagnosed rheumatoid arthritis (RA)
Authors: M Yates, J Galloway, A Rivett, S Norton, JM Ledingham, EM Dennison, AJ Macgregor, K Bechman, A Rutherford, N Snowden
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Gender has been reported to play a role in attainment of RA remission (1), but the data are inconsistent. The impact of gender in early RA therefore warrants further investigation. <h3>Objectives</h3> To assess the impact of gender on early RA outcomes. <h3>Methods</h3> An audit, designed as a national prospective longitudinal observational study, was conducted to assess early RA care. All NHS providers in England and Wales were required to participate. Follow up data were captured over 3 months for subjects with a diagnosis of RA. Logistic regression was used to estimate associations between gender and DAS-28 response. Smoking status, baseline disease activity, age, antibody status, symptom duration, referral times, and treatment were considered in multivariate models. <h3>Results</h3> 136 of 146 eligible trusts submitted data. 11,752 subjects consented, 5,622 were diagnosed with RA. DAS-28 response was available for 2234/5622 (39.7%). Male patients had a similar 3 month improvement in their DAS-28 to females, despite having a lower mean baseline score. Male gender associated with a higher rate of good EULAR response (DAS improvement &gt;1.2, follow up DAS &lt;3.3), with an adjusted odds ratio of 1.42 (CI 1.17–1.72). There were no differences between the genders in their treatment use or in other aspects of care including speed of referral (Table 1). The male excess in good EULAR response was more pronounced in seronegative compared with seropositive RA (1.98 (CI 1.4–2.8) compared to 1.21 (0.96–1.53)). <h3>Conclusions</h3> The association of male gender with improved outcomes in early RA has not been shown before in a national cohort of this scope. Previous work suggests seronegative individuals achieve greater clinical response (2), here we present this effect amplified in men. To the authors9 knowledge this is a new finding. This is likely multifactorial, with biological effect of gender, greater diagnostic uncertainty and higher reporting of global scores in women all potentially playing a role. <h3>References</h3> Svensson B, Andersson M, Forslind K, Ajeganova S, Hafstrom I. Persistently active disease is common in patients with rheumatoid arthritis, particularly in women: a long-term inception cohort study. Scan rheum. 2016;45(6):448–55. Barra L, Pope JE, Orav JE, et al. Prognosis of seronegative patients in a large prospective cohort of patients with early inflammatory arthritis. Rheum. 2014;41(12):2361–9. <h3>Disclosure of Interest</h3> None declared
AB0919 The prognostic factors during osteoarticular tuberculosis
Authors: O Saidane, M Sellami, S Cheikhrouhou, I Mahmoud, R Tekaya, L Abdelmoula
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Osteoarticular tuberculosis (OAT) is still common in Mediterranean countries such as Tunisia.The incidence of OAT is increasing, mainly related to expanding immunosuppressive factors and comorbidities. <h3>Objectives</h3> This study aimed to analyze the prognostic factors and therapeutic outcomes of OAT. <h3>Methods</h3> Over a period of 20 years [1996- 2016], patients with the diagnosis of OAT were retrospectively identified. Clinical, laboratory and radiology features in these patients were analyzed to identify the prognostic factors. <h3>Results</h3> Sixty patients (29 men) fulfilled the diagnostic criteria, admitted to the Rheumatology Service with an average of 54 years (range: 16 to 86).We did not find any significant association between prognosis and an advanced age (&gt;60years) at the time of diagnosis, a long diagnostic delay or initial neurologic involvement.However, we found that cervical localization in tuberculous spondylodiscitis, classified as an only infection site or in multi-level vertebral damage, was significantly associated to a poor prognosis.Our study revealed that hyperleucocytosis higher than 11500 elements/mm<sup>3</sup> at the initial blood count constituted the only biological bad prognostic factor during OAT. Based on radiological findings, the presence of abscess or vertebral compression fractures on bone imaging (MRI)and the presence of vertebral deformity (kyphosis or kyphoscoliosis) were strongly linked to a bad outcome.The following table (Table1) summarizes the poor prognostic factors during OAT. <h3>Conclusions</h3> This study revealed that cervical localization in tuberculous spondylodiscitis, initial hyperleucocytosis, and the presence of abscess on MRI as well as vertebral compression fractures and vertebral deformity are associated with a bad outcome in OAT. <h3>Disclosure of Interest</h3> None declared
FRI0504 Apremilast expands IL-10-producing regulatory b cells, and decreases TH1 and TH7 cells in psoriatic arthritis and psoriasis
Authors: A Mavropoulos, E Zafiriou, A Varna, E Papadopoulou, I Alexiou, A-V Roussaki-Schulze, DP Bogdanos, LI Sakkas
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> IL-10-producing regulatory B cells (Bregs), also known as B10 cells, are decreased and inversely correlate with IFN-γ- and IL-17-producing NK and T cells in patients with psoriatic arthritis (PsA) and psoriasis (Ps) (1–3) <h3>Objectives</h3> To assess whether or not apremilast, a PDE4 inhibitor recently approved for the treatment of Ps and PsA, is able to induce IL-10-producing B cells and decrease Th1 cells and Th17 cells in vivo <h3>Methods</h3> PBMCs and magnetically purified B cells were isolated from 21 patients (7 PsA, all responders; 14 Ps, 9 responders) at baseline and post-apremilast treatment (at 3 and 6 months in responders; at 3 months in non–responders, as they switched to biologicals). Phenotypic analysis of CD3, CD19, CD24, CD27, CD38 and intracellular expression of cytoplasmic IL-10, IFN-γ, IL-17 after bacterial CpG (ODN2006) and PMA/ionomycin stimulation was examined by flow cytometry <h3>Results</h3> At 6 months, apremilast significantly increased IL-10-producing Bregs (IL-10+CD19+, B10 cells) compared to baseline and 3 months. B10 cells increase was confined mainly to the transitional Bregs (CD19+CD24highCD38high) rather than memory Bregs (CD19+CD27+CD24high). IFNγ+CD3+ (Th1) and IL-17+CD3+ (Th17) T cells were significantly decreased at 3 and 6 months (p&lt;0.05, for both). There was an inverse correlation between percentages of B10 cells and IFN-γ-producing CD3+ cells. The percentage of B10 cells were not changed post-treatemnt in non-responders. <h3>Conclusions</h3> Our data suggest that apremilast may exert its therapeutic effect through the expansion of IL-10-producing Bregs and the decrease of IFN-γ- and/or IL-17-producing T cells <h3>References</h3> Mavropoulos et al Ann Rheum Dis 2015;74 Suppl 2 423. Mavropoulos et al Ann Rheum Dis 2016;75 Suppl 2 903. Mavropoulos et al Arthritis Rheumatol. 2016; 68 (suppl 10). <h3>Disclosure of Interest</h3> None declared
Phase III, Randomized, Placebo-Controlled, Double-Blind Trial of Motesanib (AMG-706) in Combination With Paclitaxel and Carboplatin in East Asian Patients With Advanced Nonsquamous Non–Small-Cell Lung Cancer
Authors: Kaoru Kubota, Hiroshige Yoshioka, Fumihiro Oshita, Toyoaki Hida, Kiyotaka Yoh, Hidetoshi Hayashi, Terufumi Kato, Hiroyasu Kaneda, Kazuhiko Yamada, Hiroshi Tanaka, Yukito Ichinose, Keunchil Park, Eun Kyung Cho, Kyung-Hee Lee, Chih-Bin Lin, James Chih-Hsin Yang, Kaori Hara, Takayuki Asato, Kazuhiko Nakagawa
Journal: Journal of Clinical Oncology (2017)

Purpose This phase III, randomized, placebo-controlled, double-blind study determined whether motesanib improved progression-free survival (PFS) compared with placebo in combination with paclitaxel and carboplatin (P/C) in East Asian patients with stage IV/recurrent nonsquamous non-small-cell lung cancer. Patients and Methods Patients were randomly assigned (1:1) to receive oral motesanib 125 mg or placebo once daily plus paclitaxel 200 mg/m2 IV and carboplatin area under the concentration-time curve 6 mg/mL ⋅ min IV for up to six 3-week cycles. Random assignment was stratified by epidermal growth factor receptor status, region, and weight loss in the 6 months before assignment. The primary end point was PFS, the key secondary end point was overall survival, and other secondary end points were objective response rate, time to tumor response, duration of response, and adverse events (AEs). Results Four hundred one patients were assigned to receive motesanib plus P/C (n = 197) or placebo plus P/C (n = 204). Median PFS was 6.1 v 5.6 months for motesanib versus placebo (stratified log-rank test P = .0825; stratified hazard ratio, 0.81; 95% CI, 0.64 to 1.03; P = .0820); median overall survival was not reached versus 21.6 months ( P = .5514). In secondary analyses, the objective response rate was 60.1% v 41.6% ( P < .001); median time to tumor response, 1.4 v 1.6 months, and median duration of response, 5.3 v 4.1 months. Incidence of grade ≥ 3 AEs (86.7% v 67.6%) and AEs that led to drug discontinuation (32.7% v 14.2%) were higher with motesanib than with placebo. AEs reported more frequently with motesanib were GI disorders, hypertension, and gallbladder related. Conclusion Motesanib plus P/C did not significantly improve PFS versus placebo plus P/C in East Asian patients with stage IV/recurrent nonsquamous non-small-cell lung cancer.
AB1188 What is the value of rheumatology on-call service? an evaluation of acute rheumatology on-call service in a tertiary centre
Authors: LH Lee, A Gupta
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Rheumatology is largely an outpatient specialty. Changes in healthcare structure in recent years have seen a trend for increased demand for specialty input in acute inpatient care. However, financial pressures on the other hand have led to calls to curtail specialty on-call service. Service provision apart, "being on-call" has traditionally been seen as an important educational experience, equipping registrars with valuable acute rheumatology skills. Despite all these, there is little published literature evaluating the contribution and workload of Rheumatology on-call service. <h3>Objectives</h3> This study sought to evaluate the contribution of Rheumatology on-call service as well as to assess the spectrum of conditions referred. <h3>Methods</h3> An electronic database was created to record details of on-call referrals received by one Rheumatology specialty registrar in a tertiary hospital. These included relevant clinical details, outcomes of referral and working diagnosis. <h3>Results</h3> A total of 40 referrals were recorded over 9 days in a 5-week period from December 2016 to January 2017. Seventeen referrals were reviewed on the same day by the rheumatology registrar. Referrals from medical wards comprised 10 out of 17 referrals reviewed. Other sources of referrals were Emergency Department, General Practitioners and Rheumatology advice phone line with 4, 2 and 1 referrals respectively. Of the 17 patients reviewed on-call, 11 referrals (65%) could be classified in the category of "acute hot joint", 2 were in the category of vasculitis and connective tissue disorders, 2 were predominantly mechanical problems, 1 was referred with a painful limb while 1 had an elevated creatine kinase. Thirteen of these 17 patients required an arthrocentesis, 12 of which were either performed or supervised by the rheumatology team. Septic arthritis was diagnosed in only one patient. Three of the 17 patients had musculoskeletal ultrasound scan performed by the rheumatology team on the same day. <h3>Conclusions</h3> Rheumatology on-call service provides a significant contribution to acute care which cannot be substituted by other specialties. It also continues to provide rheumatology trainees with experience in acute rheumatology although it could be argued that the spread of conditions seen were skewed toward acute hot joints and that exposure to connective tissue disorders and vasculitis was limited. The results of this study have important implications for planning and delivery of postgraduate Rheumatology training curriculum and delivery of on-call Rheumatology service. <h3>Disclosure of Interest</h3> None declared
THU0179 Incidence of deep vein thrombosis after total hip replacement in patients with rheumatoid arthritis
Authors: A Rybnikov, E Byalik, S Makarov, T Reshetnyak, A Khramov, E Naryshkin, D Ivanov, V Pavlov
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> The purpose of this study was to compare incidences of VTE in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) after total hip arthroplasty, different strategies for prevention of VTE and evaluate their efficiency. <h3>Objectives</h3> To evaluate the efficiency of prevention of VTE in patients with rheumatoid arthritis and osteoarthritis after total hip replacement under comparable conditions. <h3>Methods</h3> A one-year prospective cohort study was performed on 173 primary THA patients operated in V.A. Nasonova Research Institute of Rheumatology for the period 2016. Of these, 91 patients with RA (52.6%) and 82 patients with OA (47.4%). For a comparative analysis of the efficiency of anticoagulant therapy, each patient group was divided into 2 subgroups by type of drug therapy. The first - nadroparin calcium (the drug therapy was started for 12 hours after the operation at a dose of 0.1 ml per 10 kg of body weight one time per day), the second - nadroparin calcium with transfer to dabigatran etexilate (the first stage of 4 hours after the operation was started therapy by nadroparin calcium, and then after the removal of the epidural catheter moved to the dabigatran etexilate).Doppler ultrasonography (DUS) was routinely performed preoperatively and on postoperative day 7, 14, then 1 time a month for diagnosing a deep venous thrombosis (DVT). Time of observation was 6 months. <h3>Results</h3> DVT were reported in 8 (4.8%) patients, 2 of them (1.2%) with RA and 6 (3.4%) with OA. Distal DVT developed on 8 and 17 days after total hip replacement in RA patient9s group. They received nadroparin calcium only. 5 patients with VTE after surgery from OA group used nadroparin calcium and 1 patient was on combined drug therapy. Of the 8 cases of VTE - 6 (75%) were asymptomatic and 2 (25%) with development of clinical and laboratory picture. All cases of thrombosis in a group of RA was asymptomatic. In a perioperative period of clinically significant bleeding was not seen. <h3>Conclusions</h3> Cases of VTE in patients with RA, despite the large number of risk factors, under comparable conditions is significantly lower than patients with OA. The number of asymptomatic DVT dominates symptomatic both comparison groups. In patients with RA and OA who were from the first group have reported 6 cases of VTE and only 1 case of VTE have reported in patients who were from second group. Prevention of VTE by combination of LMWH and NOACs was more effective and safety in RA and OA patients. <h3>Disclosure of Interest</h3> None declared
The metabolic cross‐talk between epithelial cancer cells and stromal fibroblasts in ovarian cancer progression: Autophagy plays a role
Authors: Chanitra Thuwajit, Alessandra Ferraresi, Rossella Titone, Peti Thuwajit, Ciro Isidoro
Journal: Medicinal Research Reviews (2017)

Abstract Cancer and stromal cells, which include (cancer‐associated) fibroblasts, adipocytes, and immune cells, constitute a mixed cellular ecosystem that dynamically influences the behavior of each component, creating conditions that ultimately favor the emergence of malignant clones. Ovarian cancer cells release cytokines that recruit and activate stromal fibroblasts and immune cells, so perpetuating a state of inflammation in the stroma that hampers the immune response and facilitates cancer survival and propagation. Further, the stroma vasculature impacts the metabolism of the cells by providing or limiting the availability of oxygen and nutrients. Autophagy, a lysosomal catabolic process with homeostatic and prosurvival functions, influences the behavior of cancer cells, affecting a variety of processes such as the survival in metabolic harsh conditions, the invasive growth, the development of immune and chemo resistance, the maintenance of stem‐like properties, and dormancy. Further, autophagy is involved in the secretion and the signaling of promigratory cytokines. Cancer‐associated fibroblasts can influence the actual level of autophagy in ovarian cancer cells through the secretion of pro‐inflammatory cytokines and the release of autophagy‐derived metabolites and substrates. Interrupting the metabolic cross‐talk between cancer cells and cancer‐associated fibroblasts could be an effective therapeutic strategy to arrest the progression and prevent the relapse of ovarian cancer.
A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity
Authors: Linette Liqi Tan, Patric Pelzer, Céline Heinl, Wannan Tang, Vijayan Gangadharan, Herta Flor, Rolf Sprengel, Thomas Kuner, Rohini Kuner
Journal: Nature Neuroscience (2017)
Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
Authors: Chunhua Dai, Yan Hang, Alena Shostak, Greg Poffenberger, Nathaniel Hart, Nripesh Prasad, Neil Phillips, Shawn E. Levy, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, Seung K. Kim, Alvin C. Powers
Journal: Journal of Clinical Investigation (2017)

Inadequate pancreatic β cell function underlies type 1 and type 2 diabetes mellitus. Strategies to expand functional cells have focused on discovering and controlling mechanisms that limit the proliferation of human β cells. Here, we developed an engraftment strategy to examine age-associated human islet cell replication competence and reveal mechanisms underlying age-dependent decline of β cell proliferation in human islets. We found that exendin-4 (Ex-4), an agonist of the glucagon-like peptide 1 receptor (GLP-1R), stimulates human β cell proliferation in juvenile but not adult islets. This age-dependent responsiveness does not reflect loss of GLP-1R signaling in adult islets, since Ex-4 treatment stimulated insulin secretion by both juvenile and adult human β cells. We show that the mitogenic effect of Ex-4 requires calcineurin/nuclear factor of activated T cells (NFAT) signaling. In juvenile islets, Ex-4 induced expression of calcineurin/NFAT signaling components as well as target genes for proliferation-promoting factors, including NFATC1, FOXM1, and CCNA1. By contrast, expression of these factors in adult islet β cells was not affected by Ex-4 exposure. These studies reveal age-dependent signaling mechanisms regulating human β cell proliferation, and identify elements that could be adapted for therapeutic expansion of human β cells.
AB0568 Application of ozonated water in oral ulcer patients with behcet's disease
Authors: H Miao, L Zhang, G Zhang, K Xu
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Behcet9s disease is a systemic vasculitis disease of unknown etiology. Oral ulcer is the most common symptoms, the ulcer is various, the swelling and pain is obvious, and it is easy to recurrent, these symptoms affected the patient9s diet and life seriously.Therefore, it is important to care the patients with Behcet9s disease of oral ulcer.The ozonated water had many functions such as immune activation and immune regulation, it can induce the production of many cytokines,promote the repairment of oral epithelium.At the same time,the ozonated water had a direct effect on the nerve endings,it played a better analgesic effect, it was widely used in oral mucositis which induced by chemotherapy.But there were few studies about application ozonated water in the patients with Behcet9s disease of oral ulcer, it was not widely used in clinical practice. <h3>Objectives</h3> Apply the ozonated water in patients with Behcet9s disease,observe the effectiveness in patients with Behcet9s disease of oral ulcer. <h3>Methods</h3> From June 2014 to June 2016,82 cases of hospitalized patients with Behcet9s disease were randomly divided into study group and control group (n=41), the control group used nursing method of gentamycin sulfate solution and nystatin solution gargle alternatively,the research group using ozonated water gargle,observe and evaluate the healing effect of two groups of patients. <h3>Results</h3> The research group had significant improvement in healing oral ulcer and relieving pain (P&lt;0.05). <h3>Conclusions</h3> Ozonated water had a perfect effect in patients with Behcet9s disease of oral ulcer. <h3>References</h3> Wainstein J, Feldbrin Z, Boaz, M et al. Defficacy of ozone-oxygen therapy for the treatment of diabetic foot ulcers[J].Diabetes Technol Ther 2011;31(12):1255–1260. Kim KI, Kim JW, Lee HJ, et al. Recombinant human epidermal growth factor on oral mucositis induced by intensive chemotherapy with stem cell transplantation [J]. Am J Hematol 2013;88(2):107–112. Xiaotong Yi.The effect of ozonated water on the anti-inflammatory and wound healing of infected wound [J]. Asia Pacific Traditional Chinese medicine, 2012;8(4):331–350. Xia Wu. Effect of different nursing methods in patients with Behcet9s disease of oral ulcer [J]. Southwest Military 2010;12(3):571–572. Yuan Li, Zeju Yu, Shuling Yang, et al. Effect of ozone water treatment in oral ulcer which induced by radiotherapy[J]. Chinese Journal of nursing, 2012;18(24):2956–2957. <h3>Disclosure of Interest</h3> None declared