tbuckley/cabot-search huggingface dataset:
CD36 deficiency attenuates immune‐mediated hepatitis in mice by modulating the proapoptotic effects of CXC chemokine ligand 10
Authors: Che Xu, Chen Zhang, Jie Ji, Chao Wang, Jing Yang, Biao Geng, Ting Zhao, Hong Zhou, Xianmin Mu, Jinshun Pan, Shi Hu, Yuanfang Lv, Xingguo Chen, Hao Wen, Qiang You
Journal: Hepatology (2017)

The scavenger receptor CD36 recognizes a diverse set of ligands and has been implicated in a wide variety of normal and pathological processes, including lipid metabolism, angiogenesis, atherosclerosis, and phagocytosis. In particular, recent findings have demonstrated its crucial functions in sterile inflammation and tumor metastasis. However, the role of CD36 in immune‐mediated hepatitis remains unclear. Concanavalin A (ConA)‐induced liver injury is a well‐established experimental T cell–mediated hepatitis. To understand the role of CD36 in hepatitis, we tested the susceptibility of CD36‐deficient (CD36 −/− ) mice to this model, evaluated by a liver enzyme test, terminal deoxynucleotidyl transferase dUTP nick‐end labeling (TUNEL) assay, histological analysis, mononuclear cell (MNC) infiltration, and hepatic proinflammatory factor production. CD36 −/− mice were less sensitive to ConA‐induced hepatitis and had a significantly lower number of liver MNCs (LMNCs), including CD4 + cells, CD8 + T cells, natural killer cells, natural killer T cells, infiltrating macrophages, and neutrophils, as well as reduced expression of inflammatory mediators (tumor necrosis factor α, CXC chemokine ligand (CXCL) 10, interleukin (IL)‐1α, monocyte chemotactic protein 1, and IL‐6) compared with controls. Notably, we used bone marrow chimeric mice to demonstrate that CD36 expression on nonhematopoietic cells was required to drive ConA‐induced liver injury. Furthermore, our data show that the CD36 receptor was essential for CXCL10‐induced hepatocyte apoptosis and activation of IκB kinase, Akt, and Jun N‐terminal kinase. Moreover, treatment of wild‐type mice with genistein, a tyrosine kinase inhibitor that blocks CD36‐Lyn signaling, attenuated ConA‐induced liver injury and reduced the number of MNCs. Conclusions: Our findings suggest that CD36 plays an important proinflammatory role in ConA‐induced liver injury by promoting hepatic inflammation and mediating the proapoptotic effect of chemokine CXCL10, and therefore, may be a potential therapeutic target for immune‐mediated hepatitis. (H epatology 2018;67:1943‐1955).
Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study
Authors: Rita Guerreiro, Owen A Ross, Celia Kun-Rodrigues, Dena G Hernandez, Tatiana Orme, John D Eicher, Claire E Shepherd, Laura Parkkinen, Lee Darwent, Michael G Heckman, Sonja W Scholz, Juan C Troncoso, Olga Pletnikova, Olaf Ansorge, Jordi Clarimon, Alberto Lleo, Estrella Morenas-Rodriguez, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, Geidy E Serrano, Thomas G Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Pentti J Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F Boeve, Ronald C Petersen, Tanis J Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J Cairns, John C Morris, Stuart Pickering-Brown, David Mann, Glenda M Halliday, John Hardy, John Q Trojanowski, Dennis W Dickson, Andrew Singleton, David J Stone, Jose Bras
Journal: The Lancet Neurology (2017)
Abstract 14848: Local Brain Atrophy in Parahypocampal Gyrus is Prominent in Frail Heart Failure Patients Without Dementia
Authors: Tomomi Meguro
Journal: Circulation (2016)

Background: Heart failure (HF) patients with frailty may have potential risk of cognitive impairment (CI) that attenuates the effect of treatment. The local brain atrophy of parahippocampal gyrus i...
Virome Capture Sequencing in Castleman Disease Identifies Associations with Herpesviridae Family Members but No Novel Viruses
Authors: Christopher Sheild Nabel, Stephen Sameroff, Dustin Shilling, Jason R Ruth, Mitsuhiro Kawano, Yasuharu Sato, Noriko Iwaki, Federico Valdivieso, Michael Feldman, Katie Stone, Daisy Alapat, Frits van Rhee, Amy Chadburn, Signe Spetalen, Alexander Fosså, W. Ian Lipkin, David C Fajgenbaum
Journal: Blood (2017)
Sequencing of Postoperative Radiotherapy and Chemotherapy for Locally Advanced or Incompletely Resected Non–Small-Cell Lung Cancer
Authors: Samual Francis, Andrew Orton, Greg Stoddard, Randa Tao, Ying J. Hitchcock, Wallace Akerley, Kristine E. Kokeny
Journal: Journal of Clinical Oncology (2017)

Purpose Although several feasibility studies have demonstrated the safety of adjuvant concurrent chemoradiotherapy (CRT) for locally advanced or incompletely resected non-small-cell lung cancer (NSCLC), it remains uncertain whether this approach is superior to sequential chemotherapy followed by postoperative radiotherapy (C→PORT). We sought to determine the most effective treatment sequence. Patients and Methods Using the National Cancer Database, we selected two cohorts of patients with nonmetastatic NSCLC who had received at least a lobectomy followed by multiagent chemotherapy and radiotherapy; cohort one included patients with R0 resection and pN2 disease, whereas cohort two included patients with R1-2 resection regardless of nodal status. Overall survival (OS) was examined using a propensity score-matched analysis with a shared frailty Cox regression. Results A total of 747 patients in cohort one and 277 patients in cohort two were included, with a median follow-up of 32.8 and 27.9 months, respectively. The median OS was 58.8 months for patients who received C→PORT versus 40.4 months for patients who received CRT in cohort one (log-rank P < .001). For cohort two, the median OS was 42.6 months for patients who received C→PORT versus 38.5 months for patients who received CRT (log-rank P = .42). After propensity score matching, C→PORT remained associated with improved OS compared with CRT in cohort one (hazard ratio, 1.35; P = .019), and there was no statistical difference in OS between the sequencing groups for cohort two (hazard ratio, 1.35; P = .19). Conclusion Patients with NSCLC who undergo R0 resection and are found to have pN2 disease have improved outcomes when adjuvant chemotherapy is administered before, rather than concurrently with, radiotherapy. For patients with positive margins after surgery, there is not a clear association between treatment sequencing and survival.
An unsettled debate: Key empirical and theoretical questions are still open
Authors: Stefano Vincini, Yuna Jhang, Eugene H. Buder, Shaun Gallagher
Journal: Behavioral and Brain Sciences (2017)

Debates about neonatal imitation remain more open than Keven & Akins (K&A) imply. K&A do not recognize the primacy of the question concerning differential imitation and the links between experimental designs and more or less plausible theoretical assumptions. Moreover, they do not acknowledge previous theorizing on spontaneous behavior, the explanatory power of entrainment, and subtle connections with social cognition.
Lung volume reduction surgery in pulmonary emphysema; results of a randomised, controlled trial
Authors: P. Goldstraw, M. G. Davies, H. Koyama, D. M. Hansell, J. Bott, P. Argent, A. Heinl-Green, U. Pastorino, J. Pepper, D. M. Geddes
Journal: Thorax (1999)
Lenalidomide Effectively Induces Philadelphia-Chromosome Positive ALL Cells into Apoptosis in Synergy with Tyrosine Kinase Inhibitor
Authors: Daisuke Harama, Minori Tamai, Takeshi Inukai, Kumiko Goi, Takashi Yahata, Kiyoshi Ando, Takumi Ito, Hiroshi Handa, Kanji Sugita
Journal: Blood (2016)
Abstract 15: Utility of chemoradioselection for the optimization of treatment intensity in advanced hypopharyngeal and laryngeal carcinoma
Authors: Muneyuki Masuda, Satoshi Toh, Hidefumi Rikimaru, Naonobu Kunitake, Yuichiro Higaki
Journal: Clinical Cancer Research (2017)

Abstract Background: Definitive concomitant chemoradiotherapy (CRT) with high-dose cis-platinum (CDDP) is a current standard protocol for advanced laryngeal and hypopharyngeal cancer sparing surgery for salvage. However, this modality is associated with limited feasibility and frequent sever toxicities. We have developed a “chemoradioselection” protocol with minimal toxicity using initial response to CRT as a biomarker for patient selection. Materials and Methods: From 2000 to 2012, 123 patients with stage III (44), IV (79) laryngeal (64) and hypopharyngeal carcinoma (59) excluding T4 cases were enrolled to this protocol. Two cycles of split (15 mg/m2 x 5 days, 2000-2008) or bolus (80 mg/m2, 2009-present) CDDP was concurrently administered. Results: Tumor responses were evaluated after 40 Gy of CRT and 64 responders (i.e., chemoradioselected, CRS) received further CRT up to 70 Gy, while radical surgery was recommended for the 59 non-responders (N-CRS), and 34 underwent surgery (N-CRS-ope). The remaining 25 patients who refused surgery (N-CRS-refu) were treated with continuous CRT. The 5-yr overall survival (OS) and disease-specific survival (DSS) were 67% and 77%, respectively. The CRS demonstrated quite favorable 5-yr OS (73%) and 5-yr laryngo-esophageal dysfunction-free survival (LEDFS, 69%). In contrast, the N-CRS-refu showed significantly (P = 0.0193) lower 5-yr OS (47%) than CRS (73%) and N-CRS-ope (70%), and significantly (P &amp;lt; 0.0001) lower 5-yr LEDFS (20%) than the CRS (69%). On multivariate analyses including T, N, primary site, and planned treatment (CRS + N-CRS-ope) or not (N-CRS-refu), unplanned treatment alone showed a significant correlation with poor OS (Hazard ratio [HR]: 2.584, 95% CI: 1.313–4.354, P = 0.007). Conclusions: Chemoradioselection reflects the biological aggressiveness of each tumor, and can segregate patients for functional laryngeal preservation with moderate intensity CRT (150-160 mg/m2 of CDDP) from those who would be better treated with surgery. This strategy may be useful for the optimization of the therapeutic intensity. Citation Format: Muneyuki Masuda, Satoshi Toh, Hidefumi Rikimaru, Naonobu Kunitake, Yuichiro Higaki. Utility of chemoradioselection for the optimization of treatment intensity in advanced hypopharyngeal and laryngeal carcinoma [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr 15.
First Phase 1 Trial of a Prophylactic mRNA Vaccine Reported
Authors: Jennifer Abbasi
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immuno-related cutaneous adverse events (IRcutAEs) of anti-PD-1/anti-PD-L1 therapy in patients (p) with advanced non-small cell lung cancer (NSCLC): A single-institution prospective study.
Authors: Eudald Felip, Juan Jose Garcia, Noelia Rivera, Laura Angelats, Teresa Moran, Carlos Erasun, Laia Vilà, Max Hardy, Maria de los Llanos Gil, Aram Boada, Enric Carcereny
Journal: Journal of Clinical Oncology (2017)

e20556 Background: Despite the impressive benefits of the immune checkpoint blockade in NSCLC, its use can be hampered by the occurrence of serious adverse events. IRcutAEs are underestimated and poorly described according to data from the clinical trials. We sought to characterize the IRcutAEs and their treatment in p with NSCLC. Methods: Before starting immunotherapy, all NSCLC p were prospectively referred to the Dermatology Department. Periodic monitoring visits were also scheduled for each p, in order to describe the IRcutAEs and their treatments. The study included data from all consecutive NSCLC p treated with immunotherapy in our institution. Results: Since May 2016, 50 p were recruited for the present study. According to clinical characteristics; 18 p had squamous histology, 43 p received treatment as second line or further, and 36 p were treated with nivolumab. During the follow-up period, 15 p (30%) developed IRcutAEs. Lichenoid reactions were the most common AE (9 p, 60%), but some specific conditions were also observed, such as a cutaneous lupus (1 p, 6.6%) or an eruptive pseudoangiomatosis (1 p, 6.6%). Conclusions: IRcutAEs are common during antiPD1-PDL1 therapy. By offering a dermatological follow-up, the diagnosis and management of this type of toxicity can be provided to NSCLC p initiating immunotherapy.
Infant orofacial movements: Inputs, if not outputs, of early imitative ability?
Authors: Eoin P. O'Sullivan, Christine A. Caldwell
Journal: Behavioral and Brain Sciences (2017)

Abstract According to Keven &amp; Akins (K&amp;A), infant orofacial gestures may not reflect imitative responses. Here, we emphasise that these actions nonetheless represent a significant feature of the infant's early sensorimotor experience, and therefore may play a key role in the development of imitative capacities. We discuss how the ideas proposed in the target article could contribute substantially to experiential accounts of imitation.
Patients with rheumatoid arthritis who are overweight may be harder to treat
Authors: Jacqui Wise
Journal: BMJ (2017)

Patients with rheumatoid arthritis who are overweight or obese have worse outcomes than those who are a healthy weight, research published in Arthritis Care & Research has found.1

The Canadian Early Arthritis Cohort (CATCH) study included 982 patients with early rheumatoid arthritis, of whom 32% had a healthy body mass index (18.5-24.9), 35% were overweight (BMI 25.0-29.9), and 33% were obese (BMI ≥30). The patients were treated by rheumatologists as per guidelines with disease modifying antirheumatic drugs (DMARDs) followed by biologics. Treatment did not differ between the three groups.

Overall, 355 patients (36%) achieved sustained remission in the three years after diagnosis. …
Association Between Microinfarcts and Blood Pressure Trajectories
Authors: Jonathan Graff-Radford, Mekala R. Raman, Alejandro A. Rabinstein, Scott A. Przybelski, Timothy G. Lesnick, Bradley F. Boeve, Melissa E. Murray, Dennis W. Dickson, R. Ross Reichard, Joseph E. Parisi, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Kejal Kantarci
Journal: JAMA Neurology (2017)

Cerebral microinfarcts are associated with increased risk of cognitive impairment and may have different risk factors than macroinfarcts. Subcortical microinfarcts are associated with declining blood pressure (BP) in elderly individuals.To investigate BP slopes as a risk factor for microinfarcts.From the population-based Mayo Clinic Study of Aging, 303 of 1158 individuals (26.2%) in this cohort study agreed to have an autopsy between November 1, 2004, and March 31, 2016. Cerebral microinfarcts were identified and classified as cortical or subcortical. Baseline and BP trajectories were compared for groups with no microinfarcts, subcortical microinfarcts, and cortical microinfarcts. A secondary logistic regression analysis was performed to assess associations of subcortical microinfarcts with midlife hypertension, as well as systolic and diastolic BP slopes.The presence of cerebral microinfarcts using BP slopes.Of the 303 participants who underwent autopsy, 297 had antemortem BP measurements. Of these, 177 (59.6%) were men; mean (SD) age at death was 87.2 (5.3) years. The autopsied individuals and the group who died but were not autopsied were similar for all demographics except educational level with autopsied participants having a mean of 1 more year of education (1.06; 95% CI, 0.66-1.47 years; P < .01). Among 297 autopsied individuals with antemortem BP measurements, 47 (15.8%) had chronic microinfarcts; 30 (63.8%) of these participants were men. Thirty (63.8%) had cortical microinfarcts, 19 (40.4%) had subcortical microinfarcts, and 4 (8.5%) had only infratentorial microinfarcts. Participants with microinfarcts did not differ significantly on baseline systolic (mean difference, -1.48; 95% CI, -7.30 to 4.34; P = .62) and diastolic (mean difference of slope, -0.90; 95% CI, -3.93 to 2.13; P = .56) BP compared with those with no microinfarcts. However, participants with subcortical microinfarcts had a greater annual decline (negative slope) of systolic (mean difference of slope, 4.66; 95% CI, 0.13 to 9.19; P = .04) and diastolic (mean difference, 3.33; 95% CI, 0.61 to 6.06; P = .02) BP.Subcortical microinfarcts were associated with declining BP. Future studies should investigate whether declining BP leads to subcortical microinfarcts or whether subcortical microinfarcts are a factor leading to declining BP.
Abstract 18288: The Ablation Index of a Point Lesion is Associated With Lesion Formation Via Measurements of the Regional Change in Late Gadolinium Enhancement and T2 Intensity Following Atrial Fibrillation Ablation
Authors: Esra Gucuk Ipek, Tarek Zghaib, Muhammad Adnan Balouch, Sohail Zahid, Satish Misra, Adityo Prakosa, Jonathan Chrispin, Dong Huang, Ashkan Malayeri, Rob J van der Geest, Joseph E Marine, David Spragg, Hiroshi Ashikaga, Ronald D Berger, Natalia Trayanova, Stefan L Zimmerman, Hugh Calkins, Saman Nazarian
Journal: Circulation (2016)

Introduction: The Ablation Index (AI) in the CARTO® 3 VISITAG™ Module (Biosense Webster Inc) is a novel measurement that provides a composite metric for ablation and is based on evaluation of power...
Dental calculus: the calcified biofilm and its role in disease development
Authors: Aliye Akcalı, Niklaus P. Lang
Journal: Periodontology 2000 (2017)

Abstract Dental calculus represents the first fossilized record of bacterial communities as a testimony of evolutionary biology. The development of dental calculus is a dynamic process that starts with a nonmineralized biofilm which eventually calcifies. Nonmineralized dental biofilm entraps particles from the oral cavity, including large amounts of oral bacteria, human proteins, viruses and food remnants, and preserves their DNA . The process of mineralization involves metabolic activities of the bacterial colonies and strengthens the attachment of nonmineralized biofilms to the tooth surface. From a clinical point of view, dental calculus always harbors a living, nonmineralized biofilm, jeopardizing the integrity of the dento‐gingival or implanto‐mucosal unit. This narrative review presents a brief historical overview of dental calculus formation and its clinical relevance in modern periodontal practice.
Abstract IA03: Detection of tumor DNA in the saliva and plasma of patients with HNSCC
Authors: Nishant Agrawal
Journal: Clinical Cancer Research (2017)

Abstract To explore the potential of tumor-specific DNA as a biomarker for head and neck squamous cell carcinomas (HNSCC), we queried DNA from saliva or plasma of 93 HNSCC patients. We searched for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were tested, tumor DNA was detected in 96% of 47 patients. The fractions of patients with detectable tumor DNA in early and late-stage disease were 100% (n = 10) and 95% (n = 37), respectively. When segregated by site, tumor DNA was detected in 100% (n = 15), 91% (n = 22), 100% (n = 7), and 100% (n = 3) of patients with tumors of the oral cavity, oropharynx, larynx, and hypopharynx, respectively. In saliva, tumor DNA was found in 100% of patients with oral cavity cancers and in 47 to 70% of patients with cancers of the other sites. In plasma, tumor DNA was found in 80% of patients with oral cavity cancers, and in 86 to 100% of patients with cancers of the other sites. Thus, saliva is preferentially enriched for tumor DNA from the oral cavity, whereas plasma is preferentially enriched for tumor DNA from the other sites. Tumor DNA in saliva was found postsurgically in three patients before clinical diagnosis of recurrence, but in none of the five patients without recurrence. Tumor DNA in the saliva and plasma appears to be a potentially valuable biomarker for detection of HNSCC. Citation Format: Nishant Agrawal. Detection of tumor DNA in the saliva and plasma of patients with HNSCC [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr IA03.
Abstract 16477: Targeting Prolyl-isomerase-1 Protects Against Hyperglycemia-induced Endothelial Dysfunction and Vascular Inflammation: Alterations in Patients With Type 2 Diabetes
Authors: Francesco Paneni, Sarah Costantino, Lorenzo Castello, Rodolfo Battista, Giuliana Capretti, Sergio Chiandotto, Massimo Volpe, Thomas Lüscher, Francesco Cosentino
Journal: Circulation (2013)

Introduction: Prolyl-isomerase-1 (Pin1) regulates function of protein substrates through isomerization of peptide bonds that link phosphoserine or phosphothreonine to proline. Recent studies showed...
Ultrastretchable Kirigami Bioprobes
Authors: Yusuke Morikawa, Shota Yamagiwa, Hirohito Sawahata, Rika Numano, Kowa Koida, Makoto Ishida, Takeshi Kawano
Journal: Advanced Healthcare Materials (2017)

An ultrastretchable film device is developed that can follow the shape of spherical and large deformable biological samples such as heart and brain tissues. Although the film is composed of biocompatible parylene for the device substrate and metal layers of platinum (Pt)/titanium (Ti), which are unstretchable materials, the film shows a high stretchability by patterning slits as a "Kirigami" design. A Pt/Ti-microelectrode array embedded in 11 µm thick parylene film with 5 × 91 slits exhibits a film strain of ≈250% at 9 mN strain-force (0.08 MPa in stress) with a Young's modulus of 23 kPa, while the 3 × 91-slit film shows a Young's modulus of 3.6 kPa. The maximum strains of these devices are ≈470% and ≈840%, respectively. It is demonstrated that the Kirigami-based microelectrode device can simultaneously record in vivo electrocorticogram signals from the visual and barrel cortices of a mouse by stretching the film and tuning the electrode gap. Moreover, wrapping the Kirigami device around a beating mouse's heart, which shows large and rapid changes in the volume and the surface area, can record the in vivo epicardial electrocardiogram signals. Such a small Young's modulus for a stretchable device reduces the device's strain-force, minimizing the device-induced stress to soft biological tissues.
Dynamic epigenomic landscapes during early lineage specification in mouse embryos
Authors: Yu Zhang, Yunlong Xiang, Qiangzong Yin, Zhenhai Du, Xu Peng, Qiujun Wang, Miguel Fidalgo, Weikun Xia, Yuanyuan Li, Zhen-ao Zhao, Wenhao Zhang, Jing Ma, Feng Xu, Jianlong Wang, Lei Li, Wei Xie
Journal: Nature Genetics (2017)