tbuckley/cabot-search huggingface dataset:
Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice
Authors: Mitchell Bijnen, Tatjana Josefs, Ilona Cuijpers, Constantijn J Maalsen, José van de Gaar, Maria Vroomen, Erwin Wijnands, Sander S Rensen, Jan Willem M Greve, Marten H Hofker, Erik A L Biessen, Coen D A Stehouwer, Casper G Schalkwijk, Kristiaan Wouters
Journal: Gut (2017)

Objective Obesity is a risk factor for non-alcoholic steatohepatitis (NASH). This risk has been attributed to visceral adipose tissue (vAT) expansion associated with increased proinflammatory mediators. Accumulation of CD11c + proinflammatory adipose tissue macrophages (ATM) is an important driver of vAT inflammation. We investigated the role of ATMs in hepatic inflammation during NASH development. Design vAT isolated from lean, obese or ATM-depleted (using clodronate liposomes) obese mice was transplanted to lean ldlr -/- acceptor mice. Systemic and hepatic inflammation was assessed either after 2 weeks on standard chow or after 8 weeks on high cholesterol diet (HCD) to induce NASH. Results Transplanting donor vAT from obese mice increased HCD-induced hepatic macrophage content compared with lean-transplanted mice, worsening liver damage. ATM depletion prior to vAT transplantation reduced this increased hepatic macrophage accumulation. On chow, vAT transplantation induced a more pronounced increase in circulating and hepatic neutrophil numbers in obese-transplanted than lean-transplanted mice, while ATM depletion prior to vAT transplantation reversed this effect. Microarray analysis of fluorescence-activated cell sorting of CD11c + and CD11c − macrophages isolated from donor adipose tissue showed that obesity resulted in enhanced expression of neutrophil chemotaxis genes specifically in CD11c + ATMs. Involvement of the neutrophil chemotaxis proteins, CXCL14 and CXCL16, was confirmed by culturing vAT. In humans, CD11c expression in vAT of obese individuals correlated with vAT expression of neutrophil chemotactic genes and with hepatic expression of neutrophil and macrophage marker genes. Conclusion ATMs from obese vAT induce hepatic macrophage accumulation during NASH development, possibly by enhancing neutrophil recruitment.
Informe de un caso de difteria adquirido en el laboratorio
Authors: H. K. Geiss, W Kiehl, W Thilo
Journal: Eurosurveillance (1997)

En Marzo de 1996, una tecnico de laboratorio de 41 anos de edad empezo a presentar malestar, fiebre moderada, dolor de garganta, ronquera y disfagia. Inicialmente recibio un tratamiento sintomatico. Un dia mas tarde, la paciente fue vista en la sala de urgencias de una clinica de otorrino-laringologia con signos de disnea, tumefaccion masiva faringea, una falsa membrana que se extendia mas alla de la amigdala derecha hasta el velo del paladar, adenopatia y edema cervical. Se hizo un diagnostico presuntivo de difteria e inmediatamente se realizo traqueotomia.
TCT-20 Ten-year clinical outcome in patients with Coronary Chronic Total Occlusions not revascularized by Percutaneous Coronary Intervention according to left ventricle systolic function
Authors: Luca Baldetti, Cosmo Godino, Alessia Giannattasio, Andrea Munafò, Carlo Andrea Pivato, Andrea Scotti, Alessandro Beneduce, Giulia Perfetti, Alberto Cappelletti, Valeria Magni, Mauro Carlino, Alberto Margonato, Antonio Colombo
Journal: Journal of the American College of Cardiology (2017)
Multifunctional nanoparticles co-delivering EZH2 siRNA and etoposide for synergistic therapy of orthotopic non-small-cell lung tumor
Authors: Zhi-qiang Yuan, Wei-liang Chen, Ben-gang You, Yang Liu, Shu-di Yang, Ji-zhao Li, Wen-jing Zhu, Xiao-feng Zhou, Chun Liu, Xue-nong Zhang
Journal: Journal of Controlled Release (2017)
La notification électronique au service d’une déclaration des maladies infectieuses rapide et exhaustive, Pays-Bas, 2003
Authors: M Ward, P Brandsema, E van Straten, A Bosman
Journal: Eurosurveillance (2005)

En 2002, l’introduction aux Pays-Bas du systeme de notification OSIRIS, en ligne, via Internet a totalement remplace le systeme base sur des formulaires imprimes. Les objectifs d’OSIRIS etaient d’ameliorer les delais et l’exhaustivite des donnees de surveillance sur les maladies infectieuses declarees par les autorites regionales au niveau national. 
Nous avons compare les delais des declarations faites en 2001 par le systeme conventionnel avec ceux rapportes par OSIRIS en 2003. Deux types de delais ont ete compares : le delai total, defini comme le temps ecoule entre l’apparition des symptomes et la declaration au niveau national ; et le delai central, defini comme le temps ecoule entre la declaration regionale et nationale. Les valeurs medianes pour chacun des systemes ont ete comparees a l’aide du test de somme Wilcoxon Rank. Ont egalement fait l’objet d’une comparaison les declarations electroniques recues via OSIRIS en 2003 et les declarations 2001 de l’ancien systeme en tenant compte de l’exhaustivite de champs de donnees specifiques. La signification statistique des proportions des champs remplis dans chaque systeme a ete determinee a l’aide du test exact de Fischer et du test de Mantel-Haenzel avec la correction de Yates. 
Les resultats ont montre que le delai central median entre le systeme conventionnel et le systeme OSIRIS avait ete significativement reduit pour toutes les maladies, passant respectivement de 10 jours (ecart interquartile 4) en 2001 a 1 jour (ecart interquartile 1) en 2003. A l’exception des cas de paludisme, le delai total, de l’apparition des premiers symptomes a la declaration nationale, etait egalement reduit de maniere significative. De plus, les declarations OSIRIS contenaient des informations plus completes que les declarations traditionnelles. Au total, en 2003, 92,3% des champs de donnees examines etaient remplis, compares a 81,3% en 2001. 
Cette etude confirme les avantages de la declaration electronique des donnees de surveillance des maladies infectieuses en termes de delais et d’exhaustivite.
Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes
Authors: John F. O’Sullivan, Jordan E. Morningstar, Qiong Yang, Baohui Zheng, Yan Gao, Sarah Jeanfavre, Justin Scott, Celine Fernandez, Hui Zheng, Sean O’Connor, Paul Cohen, Ramachandran S. Vasan, Michelle T. Long, James G. Wilson, Olle Melander, Thomas J. Wang, Caroline Fox, Randall T. Peterson, Clary B. Clish, Kathleen E. Corey, Robert E. Gerszten
Journal: Journal of Clinical Investigation (2017)

Unbiased, "nontargeted" metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFLD) in the offspring cohort of the Framingham Heart Study (FHS) participants. We verified the relationship between DMGV and early hepatic pathology. Specifically, plasma DMGV levels were correlated with biopsy-proven nonalcoholic steatohepatitis (NASH) in a hospital cohort of individuals undergoing gastric bypass surgery, and DMGV levels fell in parallel with improvements in post-procedure cardiometabolic parameters. Further, baseline DMGV levels independently predicted future diabetes up to 12 years before disease onset in 3 distinct human cohorts. Finally, we provide all metabolite peak data consisting of known and unidentified peaks, genetics, and key metabolic parameters as a publicly available resource for investigations in cardiometabolic diseases.
Les fièvres hémorragiques virales en Europe – un contrôle efficace exige une réponse coordonnée
Authors: N Crowcroft, D Morgan, D W Brown
Journal: Eurosurveillance (2002)

Les fievres hemorragiques virales (FHV) ont attire l’attention du monde medical et du public pour de nombreuses raisons, reelles ou liees a la desinformation. Les FHV font partie des maladies les plus connues par le grand public, car elles ont la reputation d’etre excessivement contagieuses et de tuer la plupart des victimes dans des circonstances dramatiques (1,2). Pour ajouter a l’intrigue, la source de certains des virus impliques reste mysterieuse. Ils emergent et re-emergent dans de nombreux pays, plus recemment le virus Ebola en Ouganda en 2000 (3) et au Gabon en 2001-02 (4), et celui de la Fievre de Crimee Congo au Kosovo (5) et au Pakistan en 2001 (6). Dans ces regions endemiques, des epidemies importantes ont touche les populations vivant dans des endroits inaccessibles ou dans des camps de refugies ou les conditions de vie sont tres difficiles. L’insuffisance des equipements medicaux a contribue a augmenter la transmission et les mesures de lutte contre l’infection ont ete difficiles ou virtuellement impossibles a mettre en place. Ces virus constituent une menace tant que leur reservoir reste inconnu et aussi longtemps que les regions endemiques souffrent de changements ecologiques, de la pauvrete et de l’instabilite sociale. Les evenements recents depuis le 11 septembre 2001 nous rappellent leur utilisation possible comme armes et la peur que represente ce risque en sante publique.
Reply
Authors: Christopher Koh, Sasan Sakiani, Theo Heller
Journal: Hepatology (2017)

Potential conflict of interest: Nothing to report. We appreciate the interest in our work by Hillaire et al. While we proposed a new diagnostic criterion incorporating noninvasive fibrosis markers that led to greater numbers of patients diagnosed with adult cystic fibrosis liver disease (CFLD), Hillaire et al. have drawn attention to the growing recognition of noncirrhotic portal hypertensive (NCPH) liver diseases playing a larger role in CFLD. In recent publications, there appears to be a growing identification of NCPH in CFLD.1 Obviously, larger studies are needed to elucidate the true prevalence of NCPH in CFLD, and we agree with our colleagues that this may just be the tip of the iceberg. In our study, the incorporation of noninvasive fibrosis markers and vibration controlled transient elastography (VCTE) yielded seemingly higher diagnostic value in adult CFLD. It should be noted that AST‐to‐Platelet Ratio Index and Fibrosis‐4 Index have been described to be significantly elevated in CFLD patients with esophageal varices.3 Additionally, elevated VCTE measurements have also predicted the presence of esophageal varices in CFLD.4 However, if NCPH is truly more prevalent in CFLD, or is increasing, the utility of these noninvasive markers will need to be studied further given the suggestion of performance differences between cirrhotic and noncirrhotic chronic liver diseases.5 Second, we suggest that our case of nodular regenerative hyperplasia (NRH), not focal nodular hyperplasia, may be related to chronic antibiotic use. This clinical association is well described in primary immunodeficiency patients where chronic antibiotic use is typical. However, we and others agree that venopathy, first described in the 1980s by Wanless et al., continues to be a potential causative factor of NRH. Finally, we agree that there is a need in identifying clinically useful diagnostic tests and biomarkers that can identify subjects with end‐stage CFLD who may be candidates for multiple organ transplants (including liver). These tools would ideally take into account the potential existence of NCPH. The current use of the Model for End‐Stage Liver Disease (MELD) allocation policy often makes it difficult for NCPH patients to meet MELD criteria for listing given that synthetic function is often preserved for longer periods compared to cirrhosis‐related end‐stage liver disease.
TCT-272 Impact of Dual Antiplatelet Therapy on Device Thrombosis after Left Atrial Appendage Occlusion
Authors: Radoslaw Pracon, Sripal Bangalore, Zofia Dzielinska, Edyta Kaczmarska-Dyrda, Sebastian Bujak, Mateusz Solecki, Agnieszka Pskit, Agnieszka Dabrawska, Bartosz Sieradzki, Andrzej Plonski, Adam Witkowski, Marcin Demkow
Journal: Journal of the American College of Cardiology (2017)
TCT-463 Echocardiographic Impact of Residual Mitral Regurgitation on Annular Dimensions and Ventricular Volumes After Neochord Repair Procedure
Authors: Andrea Colli, Laura Besola, Erica Manzan, Eleonora Bizzotto, Nicola Pradegan, Matteo Nadali, Alessandro Fiocco, Roberto Bellu, Demetrio Pittarello, Gino Gerosa
Journal: Journal of the American College of Cardiology (2017)
Population Burden of Sudden Death Associated With Hypertrophic Cardiomyopathy
Authors: Aapo L. Aro, Sandeep G. Nair, Kyndaron Reinier, Reshmy Jayaraman, Eric C. Stecker, Audrey Uy-Evanado, Carmen Rusinaru, Jonathan Jui, Sumeet S. Chugh
Journal: Circulation (2017)
Brote de shigelosis en una institución infantil in Qeluz, Portugal 1995
Authors: A Suspiro, L Menezes
Journal: Eurosurveillance (1996)

La introduccion de la Shigella en una guarderia conlleva un elevado riesgo de casos secundarios por transmision persona a persona (1). Notificamos un brote de shigelosis que tuvo lugar a comienzos de 1995 que afecto a 99 ninos, 17 de sus contactos y 7 trabajadores en una guarderia para ninos menores de 10 anos. La autoridad sanitaria cerro la institucion durante 5 dias para controlar el brote y se localizo a todas las familias en riesgo para suministrarles el apropiado tratamiento antimicrobiano a los afectados.
La vigilancia epidemiológica de las enfermedades infecciosas en el Norte de Portugal durante la copa de fútbol EURO 2004
Authors: G Gonçalves, L Castro, A M Correia, Laurinda Queirós
Journal: Eurosurveillance (2005)

Entre el 12 de junio y el 4 de julio de 2004 tuvo lugar en Portugal la copa de futbol EURO 2004. La Autoridad regional de salud del Norte cubre una poblacion de 3,2 millones de personas. En esta region se desarrollaron 12 encuentros, mas que en cualquier otra region. En este articulo describimos las actividades de vigilancia de las enfermedades transmisibles en esta region durante el EURO 2004. Se detectaron diez brotes de toxi-infecciones alimentarias, asi como siete casos de enfermedad meningococica y un caso de legionelosis. Ningun visitante resulto afectado y los casos confirmados entre los residentes no parecen haber sido influidos por la presencia de miles de visitantes. Un perfil similar a este tambien se observo en otros eventos masivos, en los cuales se habian llevado a cabo actividades especiales de vigilancia epidemiologica. Esto no reduce la importancia de la vigilancia de salud publica en eventos de grandes masas. Ademas, la evaluacion de estas actividades especiales de vigilancia deberia ser una oportunidad para considerar cuestiones relativas a los recursos, las prioridades, la organizacion y la formacion en el area de la vigilancia de las enfermedades transmisibles.
S-sulfocysteine/NMDA receptor–dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency
Authors: Avadh Kumar, Borislav Dejanovic, Florian Hetsch, Marcus Semtner, Debora Fusca, Sita Arjune, Jose Angel Santamaria-Araujo, Aline Winkelmann, Scott Ayton, Ashley I. Bush, Peter Kloppenburg, Jochen C. Meier, Guenter Schwarz, Abdel Ali Belaidi
Journal: Journal of Clinical Investigation (2017)

Molybdenum cofactor deficiency (MoCD) is an autosomal recessive inborn error of metabolism characterized by neurodegeneration and death in early childhood. The rapid and progressive neurodegeneration in MoCD presents a major clinical challenge and may relate to the poor understanding of the molecular mechanisms involved. Recently, we reported that treating patients with cyclic pyranopterin monophosphate (cPMP) is a successful therapy for a subset of infants with MoCD and prevents irreversible brain damage. Here, we studied S-sulfocysteine (SSC), a structural analog of glutamate that accumulates in the plasma and urine of patients with MoCD, and demonstrated that it acts as an N-methyl D-aspartate receptor (NMDA-R) agonist, leading to calcium influx and downstream cell signaling events and neurotoxicity. SSC treatment activated the protease calpain, and calpain-dependent degradation of the inhibitory synaptic protein gephyrin subsequently exacerbated SSC-mediated excitotoxicity and promoted loss of GABAergic synapses. Pharmacological blockade of NMDA-R, calcium influx, or calpain activity abolished SSC and glutamate neurotoxicity in primary murine neurons. Finally, the NMDA-R antagonist memantine was protective against the manifestation of symptoms in a tungstate-induced MoCD mouse model. These findings demonstrate that SSC drives excitotoxic neurodegeneration in MoCD and introduce NMDA-R antagonists as potential therapeutics for this fatal disease.
TCT-832 Treatment of left main coronary artery stenosis with the STENTYS self-expandable drug-eluting stent – a multicenter registry
Authors: Wojciech Wanha, Maksymilian Mielczarek, Grzegorz Smolka, Tomasz Roleder, Miłosz Jaguszewski, Michal Chmielecki, Stanislaw Bartus, Adam Sukiennik, Jacek Kubica, Andrzej Lekston, Michal Hawranek, Krzysztof Reczuch, Andrzej Ochala, Wojtek Wojakowski
Journal: Journal of the American College of Cardiology (2017)
Brote de sarampión en adolescentes, Bélgica, 1996
Authors: K De Schrijver
Journal: Eurosurveillance (1996)

El sarampion es una enfermedad aguda sumamente contagiosa que se caracteriza por la presencia de fiebre, tos, coriza, conjuntivitis, una erupcion maculopapular eritematosa y un enantema patognomonico (manchas de Koplik). Un diez por ciento de los casos padece complicaciones tales como otitis media y bronconeumonia, y en uno de cada 1000 casos se produce encefalitis. Las complicaciones ocurren con mayor frecuencia en adultos. Tres de cada 1000 casos notificados en los Estados Unidos desde 1989, han fallecido (1).
TCT-196 Outcomes of Radial Compared with Femoral Artery Access in Patients Undergoing PCI for Left Main Disease: Analysis from the EXCEL Trial
Authors: Shmuel Chen, Bjorn Redfors, Yangbo Liu, Ori Ben-Yehuda, Marie-Claude Morice, Martin Leon, David Kandzari, Roxana Mehran, Nicholas Lembo, Adrian Banning, A. Pieter Kappetein, Joseph Sabik, Patrick Serruys, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Microcystic variant of urothelial carcinoma in urinary bladder: A case report
Authors: Yutaro Sasaki, Masatsugu Komori, Ryoichi Nakanishi, Hirofumi Izaki, Kazuya Kanda, Toru Inai, Kazuyoshi Izumi, Tomoteru Kishimoto, Masahito Yamanaka, Yasuo Kawanishi
Journal: Annals of Oncology (2017)
TCT-177 Assessing Coronary Artery Disease by Cardiac Phase Tomography Using Machine-Learned Algorithms in Obese and Elderly Subjects
Authors: Tom Stuckey, Narendra Singh, Robi Goswami, Jeremiah Depta, Roger Gammon, John Steuter, Michael Roberts, Sunny Gupta, William Sanders
Journal: Journal of the American College of Cardiology (2017)
TCT-80 Incidence, Predictors, and Outcomes of New-Onset Atrial Fibrillation and Flutter After PCI or CABG for Left Main Disease: Analysis From the EXCEL Trial
Authors: Ioanna Kosmidou, A. Pieter Kappetein, Patrick Serruys, Bernard Gersh, David Kandzari, Marie-Claude Morice, Andrzej Bochenek, Erick Schampaert, Pierre Page, Joseph Sabik, Thomas McAndrew, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Phase II study of metronomic chemotherapy (MC) with bevacizumab (B) in patients (Pts) with advanced (Adv) nonsquamous non-small cell lung cancer (NS-NSCLC).
Authors: Carrie Lee Marquette, Stefan C. Grant, Mollie DeShazo, Vishnu Reddy, Alan Cantor, Debi Miley, Mary Jerome, Francisco Robert
Journal: Journal of Clinical Oncology (2013)

8057 Background: Targeting vascular endothelial growth factor (VEGF) has shown modest improvement in pts with adv NS-NSCLC. The incorporation into MC regimens of antiangiogenic agents has been shown to further enhance efficacy in preclinical models. The goal of this pilot study was to achieve a 30% improvement in the 6.4 months (M) progression-free survival (PFS) observed in ECOG 4599. Methods: Untreated pts with stage 4 NS-NSCLC, PS 0-1 and measurable disease were treated with a 4-week (W) cycle of paclitaxel (80mg/m 2 D1, 8, 15), gemcitabine (G) (200-300mg/m 2 D1, 8, 15) and B (10mg/m 2 D1, 15) for 6 cycles. Pts without progressive disease or significant toxicity (Tx) received maintenance B every 2 w. Primary endpoint:PFS. Secondary endpoints: ORR, OS, Tx and biomarker (BM) correlation. Blood samples for angiogenic (VEGF, sVEGFR2, BFGF, PLGF, PDGFα, Ang-2, IL-8, E-Selectin, ICAM-1, TGFβ-1, SDF-1α, endocan) and antiangiogenic (Thrombospondin-1, Ang-1) bm were collected at different intervals in 21 pts. Response assessment (RECIST) was performed every 8 w. Results: 33 evaluable pts were enrolled. Pt characteristics: median age 59 yrs (37-76), 60% female, 70% &gt; 5% weight loss, 24% never/light smokers, 48% genetic testing (mut EGFR-4; ALK(+)-1), and 9% brain mets. Efficacy parameters are shown in the table. 24 pts had an OR (CR-1, PR-23) and 6 pts had stable disease. No significant differences were observed in the efficacy parameters between former smokers vs. never/light smokers. Worst hematologic and non-hematologic Tx: gr 3 neutropenia (N=1); gr 3/4 nausea/vomiting (N=1); gr 3/4 fatigue (N=2); ischemic colitis (N=1); cerebral ischemia (N=1); gr 3/4 pneumonitis [related to G] (N=2); gr 3/4 proteinuria (N=3), and no gr 3/4 hypertension. Conclusions: While conclusions are limited by the size of the trial, the results are consistent with the hypothesis that the addition of B to MC may result in enhanced anti-angiogenic effect and clinical benefits in adv NS-NSCLC. Analysis of prognostic or predictive bm of angiogenesis will be presented. Clinical trial information: NCT00655850. [Table: see text]
Epidémie de rubéole dans la communauté latino-américaine, Madrid, Espagne, décembre 2002 à mars 2003
Authors: C Lemos, R Ramirez, M Ordobas, D H Guibert, J C Sanz, L Garcia, J. F. Martinez Navarro
Journal: Eurosurveillance (2004)

La couverture vaccinale contre la rubeole est elevee dans la plupart des pays d’Europe de l’Ouest. Cependant, avant l’introduction du vaccin en Amerique latine, la susceptibilite a la rubeole chez les femmes en âge de procreer variait entre 10 et 25%. Depuis 2002, 41 (93%) pays d’Amerique latine pratiquent la vaccination contre la rubeole. La population immigree adulte constitue un groupe susceptible. Au cours du mois de fevrier 2003, le Plan d’Elimination de la Rougeole de la ville de Madrid a detecte une augmentation du nombre de cas de rubeole declares chez les femmes immigrees. Une etude a alors ete realisee afin de caracteriser cette epidemie. Une etude descriptive, basee sur les resultats de laboratoires et les modes de transmission a ete realisee. Un cas confirme etait definit comme toute personne ayant presente, entre le 1er decembre 2002 et le 31 mars 2003, de la fievre ou des rougeurs et une serologie IgM positive, et vivant a Madrid. Le taux d’attaque secondaire (TAS) par foyer a ete calcule. Au total, 19 cas de rubeole ont ete identifies, dont 15 confirme et 4 probable. Quatorze (73,7%) cas etaient des femmes en âge de procreer. La moyenne d’âge etait de 25,1 ans. Un cas a ete diagnostique chez une femme enceinte et une interruption volontaire de grossesse a ete realisee. Onze (57,9%) cas venaient d’Equateur. Le temps moyen de domiciliation en Espagne etait de 41 mois. Aucun des cas ni des 54 (78,3%) contacts familiaux n’etait vaccine contre la rubeole. Le taux d’attaque secondaire etait de 9,1%. Cette etude a mis en evidence la dissemination de la rubeole dans la communaute Latino-americaine residant a Madrid. Les mesures proposees ont ete un programme de vaccination cible vers les immigres, une campagne d’education a la sante axee sur la prevention de la rubeole congenitale, et un programme de formation des professionnels de sante a la gestion des cas.