Long-Term Effectiveness of Sigmoidoscopy Screening in Women and Men
Authors: Aasma Shaukat, Timothy R. Church
Journal: Annals of Internal Medicine (2018)

Letters6 November 2018Long-Term Effectiveness of Sigmoidoscopy Screening in Women and MenAasma Shaukat, MD, MPH and Timothy R. Church, PhDAasma Shaukat, MD, MPHMinneapolis VA Health Care System, Minneapolis, Minnesota (A.S.)Search for more papers by this author and Timothy R. Church, PhDUniversity of Minnesota, Minneapolis, Minnesota (T.R.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0511 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Holme and colleagues' (1) finding that colorectal cancer (CRC) incidence and mortality did not decrease among women through 15 years of follow-up after a single flexible sigmoidoscopy adds to the growing literature on sex- and age-based differences in benefit from screening. This result is consistent with findings from the PLCO (Prostrate, Lung, Colorectal, and Ovarian) Cancer Screening Trial, which reported that screening with flexible sigmoidoscopy led to a greater reduction in CRC mortality in men (relative risk, 0.66 [95% CI, 0.53 to 0.81]) than women (hazard ratio [HR], 0.87 [CI, 0.68 to 1.12]) after 12 years of ...References1. Holme Ø, Løberg M, Kalager M, Bretthauer M, Hernán MA, Aas E, et al; NORCCAP Study Group. Long-term effectiveness of sigmoidoscopy screening on colorectal cancer incidence and mortality in women and men: a randomized trial. Ann Intern Med. 2018;168:775-82. [PMID: 29710125]. doi:10.7326/M17-1441 LinkGoogle Scholar2. Schoen RE, Pinsky PF, Weissfeld JL, Yokochi LA, Church T, Laiyemo AO, et al; PLCO Project Team. Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med. 2012;366:2345-57. [PMID: 22612596] doi:10.1056/NEJMoa1114635 CrossrefMedlineGoogle Scholar3. Shaukat A, Church TR. Colorectal-cancer incidence and mortality after screening [Letter]. N Engl J Med. 2013;369:2355. [PMID: 24328471] doi:10.1056/NEJMc1313116 CrossrefMedlineGoogle Scholar4. Brenner H, Hoffmeister M, Arndt V, Haug U. Gender differences in colorectal cancer: implications for age at initiation of screening. Br J Cancer. 2007;96:828-31. [PMID: 17311019] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Minneapolis VA Health Care System, Minneapolis, Minnesota (A.S.)University of Minnesota, Minneapolis, Minnesota (T.R.C.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0511. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men Øyvind Holme , Magnus Løberg , Mette Kalager , Michael Bretthauer , Miguel A. Hernán , Eline Aas , Tor J. Eide , Eva Skovlund , Jon Lekven , Jörn Schneede , Kjell Magne Tveit , Morten Vatn , Giske Ursin , Geir Hoff , and Long-Term Effectiveness of Sigmoidoscopy Screening in Women and Men Øyvind Holme , Magnus Løberg , Mette Kalager , Michael Bretthauer , and Geir Hoff Metrics 6 November 2018Volume 169, Issue 9Page: 663KeywordsColorectal cancerFlexible sigmoidoscopyHazard ratioHematologic testsMortalityOvarian cancer screeningRandomized trialsRelative riskRisk managementSurveillance Epidemiology and End Results ePublished: 6 November 2018 Issue Published: 6 November 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...