Clinical Practice Guidelines for Osteoporosis: Translating Data to Patients?
Authors: Eric S. Orwoll
Journal: Annals of Internal Medicine (2017)

Editorials6 June 2017Clinical Practice Guidelines for Osteoporosis: Translating Data to Patients?Eric S. Orwoll, MDEric S. Orwoll, MDFrom Oregon Health and Science University, Portland, Oregon.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M17-0957 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this issue, a clinical practice guideline from the American College of Physicians (ACP) notes that osteoporotic fractures represent an enormous public health problem (1). The size of the geriatric population is increasing, and the burden of osteoporosis and related fractures will grow. The guideline distills currently available evidence on therapeutic options for osteoporosis to update ACP's 2008 recommendations. The guideline committee used a conventional approach to update previous evidence reviews (2) supplemented with a machine-learning method through October 2016 and focused specifically on bisphosphonates, calcium, vitamin D, and estrogen. They graded the evidence and assigned recommendation strength using the ...References1. Qaseem A, Forciea MA, McLean RM, Denberg TD; Clinical Guidelines Committee of the American College of Physicians. Treatment of low bone density or osteoporosis to prevent fractures in men and women: a clinical practice guideline update from the American College of Physicians. Ann Intern Med. 2017;166:818-39. doi:10.7326/M15-1361 LinkGoogle Scholar2. Crandall CJ, Newberry SJ, Diamant A, Lim YW, Gellad WF, Booth MJ, et al. Comparative effectiveness of pharmacologic treatments to prevent fractures: an updated systematic review. Ann Intern Med. 2014;161:711-23. [PMID: 25199883]. doi:10.7326/M14-0317 LinkGoogle Scholar3. Khosla S, Cauley JA, Compston J, Kiel DP, Rosen C, Saag KG, et al. Addressing the crisis in the treatment of osteoporosis: a path forward. J Bone Miner Res. 2016. [PMID: 28099754] doi:10.1002/jbmr.3074 CrossrefMedlineGoogle Scholar4. Kolata G. Fearing rare side effects, millions take their chances with osteoporosis. New York Times. 1 June 2016. Accessed at https://www.nytimes.com/2016/06/02/health/osteoporosis-drugs-bones.html on 20 April 2017. Google Scholar5. Leder BZ, Tsai JN, Uihlein AV, Wallace PM, Lee H, Neer RM, et al. Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial. Lancet. 2015;386:1147-55. [PMID: 26144908] doi:10.1016/S0140-6736(15)61120-5 CrossrefMedlineGoogle Scholar6. Black DM, Bauer DC, Schwartz AV, Cummings SR, Rosen CJ. Continuing bisphosphonate treatment for osteoporosis—for whom and for how long? N Engl J Med. 2012;366:2051-3. [PMID: 22571169] doi:10.1056/NEJMp1202623 CrossrefMedlineGoogle Scholar7. Cummings SR, Cosman F, Lewiecki EM, Schousboe JT, Bauer DC, Black DM, et al. Goal-directed treatment for osteoporosis: a progress report from the ASBMR-NOF Working Group on Goal-Directed Treatment for Osteoporosis. J Bone Miner Res. 2017;32:3-10. [PMID: 27864889] doi:10.1002/jbmr.3039 CrossrefMedlineGoogle Scholar8. Watts NB, Adler RA, Bilezikian JP, Drake MT, Eastell R, Orwoll ES, et al; Endocrine Society. Osteoporosis in men: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97:1802-22. [PMID: 22675062] doi:10.1210/jc.2011-3045 CrossrefMedlineGoogle Scholar9. Cosman F, deBeur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, et al; National Osteoporosis Foundation. Clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014;25:2359-81. [PMID: 25182228] doi:10.1007/s00198-014-2794-2 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Oregon Health and Science University, Portland, Oregon.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-0957.Corresponding Author: Eric S. Orwoll, MD, 3181 SW Sam Jackson Park, Portland, OR 97239; e-mail, [email protected]edu.This article was published at Annals.org on 9 May 2017. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTreatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update From the American College of Physicians Amir Qaseem , Mary Ann Forciea , Robert M. McLean , Thomas D. Denberg , and Metrics Cited byAdvances in the Fabrication of Scaffold and 3D Printing of Biomimetic Bone Graft 6 June 2017Volume 166, Issue 11Page: 852-853KeywordsBone densityBone mineral densityDisclosureDrug therapyDrugsEstrogensOsteoporosisResearch designTreatment guidelinesVitamin D ePublished: 9 May 2017 Issue Published: 6 June 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...