tbuckley/cabot-search huggingface dataset:
LOWER LEG BIOMECHANICS ASYMMETRIES DURING LANDING AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Authors: Yuka Kimura, Yuji Yamamoto, Takuya Naraoka, Yukiko Karita, Eiichi Tsuda, Yasuyuki Ishibashi, Misato Makino
Journal: British Journal of Sports Medicine (2017)

Background Asymmetries in knee motion have been identified as a risk factor for second anterior cruciate ligament (ACL)injury. Objective To investigate the kinematics and kinetics of knee joint and ground reaction force during landing after ACL reconstruction (ACLR). Design Controlled laboratory study. Setting The patients after ACLR and being cleared to return to competitive sports. Patients Four males and 8 females (23.2 years) at 43 (8–152) months postoperatively. Assessment of Risk Factors The subjects performed a drop vertical jump by dropping directly down off a box, and immediately performing a maximum vertical jump. The kinematic and kinetic data of the knee joint during landing were measured using 3-dimensional motion analysis system. The concentric peak torque of the quadriceps and hamstring muscle were measured using a dynamometer. KOOS were used to measure patient-reported outcomes. Main Outcome Measurements The knee flexion and varus/valgus angle, maximum knee valgus moment and peek vertical ground reaction force (VGRF) during landing were measured. Results The knee kinematics was not significantly difference between reconstructed and intact knees. Maximum knee valgus moment of reconstructed knees during landing was 0.2±0.1 Nm/kg/m, and that of intact knees was 0.4±0.2 Nm/k/m. Peek VGRF of reconstructed knees was 1.2±0.2 N/BW, and that of intact knees was 1.7±0.3 N/BW. There was significant difference in maximum knee valgus moment and peak VGRF between reconstructed and intact knees (p&lt;0.05). Normalized muscle strength was above 80%. There were no significant correlations between knee valgus moment, VGRF, muscle strength and KOOS. Conclusions Significant asymmetry of knee valgus moment and VGRF has still been observed in ACL reconstructed patients who were satisfied to return to sports, and these were difficult to be predicted by muscle strength and subjective knee function. Assessments of biomechanical asymmetry may support a safer return to sports minimizing re-injury and contralateral injury rate for athletes.
Microbiome in lung explants of idiopathic pulmonary fibrosis: a case–control study in patients with end-stage fibrosis
Authors: Georgios D Kitsios, Mauricio Rojas, Daniel J Kass, Adam Fitch, John C Sembrat, Shulin Qin, Kristen L Veraldi, Kevin F Gibson, Kathleen Lindell, Joseph M Pilewski, Barbara Methe, Kelvin Li, John McDyer, Bryan J McVerry, Alison Morris
Journal: Thorax (2017)

The microbiome has been proposed to play a role in the progression of idiopathic pulmonary fibrosis (IPF) based on bronchoalveolar lavage analyses, but the microbiome of lung tissue in IPF has not been explored. In a case–control study of lung explants analysed by 16S rRNA gene sequencing, we could not reliably detect bacterial DNA in basilar tissue samples from patients with either chronic or acute exacerbations of IPF, in contrast to control candidate-donor lungs or cystic fibrosis explants. Thus, our data do not indicate microbiome alterations in regions of IPF lung with advanced fibrosis.
Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants
Authors: Pierre Gaudriault, Séverine Mazaud-Guittot, Vincent Lavoué, Isabelle Coiffec, Laurianne Lesné, Nathalie Dejucq-Rainsford, Martin Scholze, Andreas Kortenkamp, Bernard Jégou
Journal: Environmental Health Perspectives (2017)

Numerous chemicals are capable of disrupting androgen production, but the possibility that they might act together to produce effects greater than those of the most effective component in the mixture has not been studied directly in human tissues. Suppression of androgen synthesis in fetal life has been associated with testis maldescent, malformations of the genitalia at birth, and poor semen quality later in life.Our aim was to investigate whether chemicals can act together to disrupt androgen production in human fetal testis explants and to evaluate the importance of mixture effects when characterizing the hazard of individual chemicals.We used an organotypic culture system of human fetal testes explants called FEtal Gonad Assay (FEGA) with tissue obtained at 10 and 12 gestational wk (GW 10-12), to screen 27 chemicals individually for their possible anti-androgenic effect. Based on the results of the screen, we selected 11 compounds and tested them as mixtures.We evaluated mixtures composed of four and eight antiandrogens that contained the pharmaceuticals ketoconazole and theophylline and several previously untested chemicals, such as the pesticides imazalil and propiconazole. Mixtures of antiandrogens can suppress testosterone synthesis in human fetal testicular explants to an extent greater than that seen with individual chemicals. This revealed itself as a shift towards lower doses in the dose-response curves of individual antiandrogens that became more pronounced as the number of components increased from four to eight.Our results with the FEGA provide the foundations of a predictive human mixture risk assessment approach for anti-androgenic exposures in fetal life. https://doi.org/10.1289/EHP1014.
ADAPTED EVALUATION PROTOCOLS FOR TEENAGE ATHLETES COMPETING AT YOUTH OLYMPIC GAMES: SAFEGUARDING AND PROTECTING YOUNG CHAMPIONS
Authors: Paolo Emilio Adami, Maria Rosaria Squeo, Filippo Maria Quattrini, Fernando Maria Di Paolo, Cataldo Pisicchio, Roberto Ciardo, Luisa Verdile, Stefano Caselli, Viviana Maestrini, Antonio Spataro, Antonio Pelliccia
Journal: British Journal of Sports Medicine (2017)

Background Currently no clear indication are present for the pre-participation evaluation of adolescent elite athletes. Objective Our objective was to assess the efficacy of a tailored pre-participation evaluation protocol to assess health and eligibility of adolescent athletes, shortlisted for participation in the Youth Olympic Games. Design Setting and Patients Between 2010 and 2014, 247 adolescent elite athletes (53% females), mean age 16.3±1.01 years, competing in 22 summer and 15 winter sport disciplines, were evaluated through a tailored pre-participation protocol, which included 10 different health specialists. Main Outcome Measurements In 36 of the 247 athletes (14.5%), the pre-participation evaluation led to the final diagnosis of a pathological condition, including CV in 17 (6.8%), pulmonary in 11 (4.5%), endocrine in 5 (2.0%), infectious, neurological and psychiatric disorders in 1 each (0.4%). Among CV abnormalities, atrial septal defects were observed in 9 (3.6%), valvular diseases in 5 (2.0%), primary tachyarrhythmias in 2 (0.8%) and hypertension in 1 (0.4%). Pulmonary diseases consisted of allergic asthma, diagnosed in 11. Endocrine diseases included Hashimoto's Thyroiditis in 2, Hypothyroidism in 2 and Androgen Insensitivity Syndrome in the remaining subject. Hepatitis B, Epilepsy Syndrome and Panic Disorder represented the remaining diagnoses, each in one individual. Results Based on current National and International Recommendations, none of the athletes was considered at high risk for acute events and all were eligible to compete at the Youth Olympic Games. All athletes with pathological conditions or abnormal findings were required to undergo a periodic follow up. Conclusions The specific pre-participation evaluation protocol implemented proved to be effective in identifying a wide range of disorders, in a significant proportion (14.5%) of adolescent Olympic athletes. The presented protocol should be considered for early identification of a wide spectrum of diseases in this population of athletes, allowing prompt treatment and minimising health consequences.
Platelet Reactivity in Patients with ST-elevation or Non-ST Elevation Acute Coronary Syndromes Receiving Prasugrel
Authors: Ichikawa Shinya, Tsukahara Kengo, Akiyama Eiichi, Maejima Nobuhiko, Iwahashi Noriaki, Hibi Kiyoshi, Kosuge Masami, Ebina Toshiaki, Umemura Satoshi, Kimura Kazuo
Journal: Circulation (2016)
軟骨再生のためのデカップルした機械的及び生化学的キューを用いたエラスチン様蛋白質ヒアルロン酸(ELP HA)ヒドロゲル【Powered by NICT】
Authors: Zhu Danqing, Wang Huiyuan, Trinh Pavin, C Heilshorn Sarah, Yang Fan
Journal: Biomaterials (2017)
The contribution of health risk behaviors to excess mortality in American adults with chronic hepatitis C: A population cohort‐study
Authors: Hamish Innes, Andrew McAuley, Maryam Alavi, Heather Valerio, David Goldberg, Sharon J. Hutchinson
Journal: Hepatology (2017)

In resource‐rich countries, chronic hepatitis C (CHC) infection is associated with a sizeable excess mortality risk. The extent to which this is due to (1) the biological sequelae of CHC infection versus (2) a high concomitant burden of health risk behaviors (HRBs) is unclear. We used data from the 1999‐2010 U.S. National Health and Nutritional Examination Surveys (NHANES), which include detailed information on HRBs and CHC infection status. We calculated the prevalence of the five major HRBs—alcohol use; cigarette smoking, physical inactivity, unhealthy diet, and illicit drug use—according to CHC after adjusting for sociodemographic differences. Mortality status after survey interview was ascertained by linkage to the U.S. National Death Index. To assess the contribution of HRBs to the excess mortality risk, we determined the all‐cause mortality rate ratio (MRR) for individuals with CHC relative to individuals without, and then calculated the attenuation in this MRR following adjustment for HRBs. This analysis included 27,468 adult participants of NHANES of which 363 tested positive for CHC. All HRBs were markedly more prevalent among individuals with CHC versus individuals without. CHC was associated with a 2.4‐fold higher mortality rate after adjustment for sociodemographic factors (MRR, 2.36; 95% CI, 1.60‐3.49). Subsequent adjustment for all five HRBs attenuated this ratio by 50.7% to MRR 1.67 (95% CI, 1.14‐2.44). Higher levels of attenuation (69.1%) were observed among individuals aged 45‐70 years, who form the target demographic for U.S. birth cohort screening. Conclusion: At least half the excess mortality risk for individuals with CHC in the United States may be attributed to HRBs rather than CHC. The remedial response to hepatitis C must not neglect action on HRBs if it is to fully resolve the high mortality problem in this population. (H epatology 2018;67:97‐107).
大きな腫瘍のための効果的な光音響pHイメージングとpH応答性光熱治療のためのアルブミンNIR染料自己集合ナノ粒子【Powered by NICT】
Authors: Chen Qian, Liu Xiaodong, Zeng Jianfeng, Cheng Zhenping, Liu Zhuang
Journal: Biomaterials (2016)
Mitochondrial DNA transversion mutation is associated with familial medullary thyroid carcinoma/multiple endocrine neoplasia type 2 syndrome
Authors: Khaled K. Abu-Amero, Ali S. Alzahrani, Minjing Zou, Yufei Shi
Journal: Cancer Research (2006)

432   Medullary thyroid carcinoma (MTC) is a malignant tumor of the calcitonin-secreting parafollicular C cells of the thyroid and occurs sporadically or as a component of the multiple endocrine neoplasia (MEN) type 2/familial medullary thyroid carcinoma (FMTC) syndromes. In the present study, we investigated the frequency of mtDNA mutations in 26 MTC tumor specimens (13 sporadic and 13 familial MTC) and their matched normal tissues by sequencing the entire coding regions of mitochondrial genome. Germ-line mutations were detected in 20 MTC samples (76.9 %): 9 out of 13 sporadic MTC (69.2 %) and 11 out of 13 (84.6 %) familial MTC/MEN2. Both transition and transversion type of mutations were found in the samples. Interestingly, 76.2 % (16/21) of transversion mutations were found in FMTC/MEN2 patients, whereas 66.7 % (12/18) of transition mutations were in sporadic MTC. The association of transversion mutation with familial MTC/MEN2 was statistically significant ( p  =0.002). Majority of the mutations were involved in the genes located in the complex I of the mitochondrial genome and was often resulting in a change of a moderately or highly conserved amino acid of their corresponding protein. Mitochondrial respiratory function was also compromised in TT cell line, which carry mtDNA mutation at nt 4917 and nt 11720, and in peripheral lymphocytes of MTC patients with mtDNA mutations. These data suggest that mtDNA mutation may be involved in MTC tumorigenesis. Given that mtDNA mutation spectra are different between sporadic and familial MTC, different mechanism of oxidative DNA damage may occur in the disease process.
Defect in B Cell Production Driven By GATA2 Mutation Results in Their Absolute Reduction and Mature Phenotype in Pediatric Patients
Authors: Michaela Novakova, Ales Janda, Marcin W Wlodarski, Martina Sukova, Vit Campr, Marketa Kubricanova Zaliova, Eva Fronkova, Elena Vodickova, Ondrej Zapletal, Jan Blatny, Katerina Lejhancova, Dagmar Pospisilova, Zdena Cerna, Tomas Kuhn, Zuzana Zemanova, Jan Trka, Ondrej Hrusak, Jan Stary, Ester Mejstrikova
Journal: Blood (2014)
Intraoperative Diagnosis of Anderson-Fabry Disease in Patients With Obstructive Hypertrophic Cardiomyopathy Undergoing Surgical Myectomy
Authors: Franco Cecchi, Maria Iascone, Niccolò Maurizi, Laura Pezzoli, Irene Binaco, Elena Biagini, Maria Laura Fibbi, Iacopo Olivotto, Federico Pieruzzi, Ana Fruntelata, Lucian Dorobantu, Claudio Rapezzi, Paolo Ferrazzi
Journal: JAMA Cardiology (2017)

Diagnostic screening for Anderson-Fabry cardiomyopathy (AFC) is performed in the presence of specific clinical red flags in patients with hypertrophic cardiomyopathy (HCM) older than 25 years. However, left ventricular outflow tract obstruction (LVOTO) has been traditionally considered an exclusion criteria for AFC.To examine a series of patients diagnosed with HCM and severe basal LVOTO undergoing myectomy in whom the diagnosis of AFC was suspected by the cardiac surgeon intraoperatively and confirmed by histological and genetic examinations.This retrospective analysis of patients undergoing surgical septal reduction strategies was conducted in 3 European tertiary referral centers for HCM from July 2013 to December 2016. Patients with a clinical diagnosis of obstructive HCM referred for surgical management of LVOTO were observed for at least 18 months after the procedure (mean [SD] follow-up, 33 [14] months).Etiology of patients with HCM who underwent surgical myectomy.From 2013, 235 consecutive patients with a clinical diagnosis of HCM underwent septal myectomy. The cardiac surgeon suspected a storage disease in 3 patients (1.3%) while inspecting their heart samples extracted from myectomy. The mean (SD) age at diagnosis for these 3 patients was 42 (4) years; all were male. None of the 3 patients presented with extracardiac features suggestive of AFC. All patients showed asymmetrical left ventricular hypertrophy, with maximal left ventricular thickness in the basal septum (19-31 mm), severe basal LVOTO (70-120 mm Hg), and left atrial dilatation (44-57 mm). Only 1 patient presented with late gadolinium enhancement on cardiovascular magnetic resonance at the right ventricle insertion site. The mean (SD) age at surgical procedure was 63 (5) years. On tactile sensation, the surgeon felt a spongy consistency of the surgical samples, different from the usual stony-elastic consistency typical of classic HCM, and this prompted histological examinations. Histology showed evidence of intracellular storage, and genetic analysis confirmed a GLA A gene mutation (p.Asn215Ser) in all 3 patients.Screening for AFC should be performed even in the absence of red flags in patients with HCM older than 25 years.
SAT0355 Neuropathic pain: is it an underestimated symptom in systemic sclerosis?
Authors: N Cuzdan Coskun, I Turk, T Sarpel, E Erken, ZN Alparslan
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Pain is one of the most common symptoms in SSc patients, yet not considered in the assessment of disease severity. Former studies have shown that pain has a neuropathic component; however there is still lack of evidence about its distribution in the body regions and the direct effect of neuropathic pain on the quality of life (QoL). <h3>Objectives</h3> We aimed to investigate the frequency of neuropathic pain syndrome (NPS) and to evaluate its interference with the quality of life in SSc patients. <h3>Methods</h3> Diffuse and Limited SSc patients diagnosed by <i>American College of Rheumatology</i> 2013 criteria were included in the study. Pain was evaluated with <i>Visual Analogue Scale</i> (VAS); painful body regions and pain intensity with <i>Brief Pain Inventory</i> (BPI); presence of neuropathic pain with <i>The Leeds Assessment of Neuropathic</i><i>Symptoms and Signs</i> (LANNS) questionnaire; disease activity with <i>Medsger Disease Severity Scale</i> and QoL with <i>Short-form 36</i> (SF36). Multiple regression analysis was used to assess the associations of NPS with sociodemographic and clinical factors. <h3>Results</h3> One hundred twenty patients were included in the study (mean age 53.64±11.44 years, female/male 83.3%&gt;16.7%). Total pain frequency was found 69.2% and NPS was 35.9% in the whole patient group. Mean VAS in the group of patients with and without NPS were 5.44±2.03, 3.45±1.82; respectively (<i>P</i>&lt;0.001). Pain was most frequently seen in wrist-hand (50.6%) and ankle-foot (43.4%) regions; albeit, NPS rates were highest in face (94.4%), lower leg (87.5%) and gluteal (78.6%) regions. SF 36 scores were lower in patients with NPS than the patients without NPS but the difference has not reached to a statistically significant level (<i>P</i>&gt;0.05). The most associated factors with NPS were Medsger Disease Severity Score for muscle and drug consumption of the patient. <h3>Conclusions</h3> According to our results, high frequency of NPS is seen in SSc patients, and NPS is associated with low QoL. The highest rates of NPS presence were seen in face, gluteal and lower leg regions of the body. Differential diagnosis of NPS is important to consider right treatment options and accurate management of pain in all rheumatologic diseases including SSc. <h3>Disclosure of Interest</h3> None declared
Quels sont les facteurs prédictifs de la tolérance à la coloscopie? Une étude multicentrique européenne (EPAGE)
Authors: F Froehlich, V Wietlisbach, JP Vader, B Burnand, JJ Gonvers
Journal: Endoscopy (2004)

Introduction: La tolérance à la coloscopie n’a jamais été évaluée de manière multicentrique sur un plan européen. Patients et Méthodes: Vingt et un centres (20 européens et 1 canadien) ont participé à cette étude prospective. La tolérance à la coloscopie (échelle de 1–6: très tolérable à extrêmement intolérable), la douleur (échelle de 1–10) et la volonté de répéter l’examen ont été évaluées par un questionnaire rempli par le patient après l’examen. Un modèle multivarié de régression logistique a été utilisé pour déterminer quelles caractéristiques des patients (sexe, âge, risque ASA, indication clinique, diagnostic endoscopique) et quels paramètres techniques (difficulté de l’examen, durée, qualité de la préparation colique, type de sédation, fluoroscopie, examen complet ou non) représentent des facteurs prédictifs indépendants d’un examen jugé douloureux (douleur > 3) ou d’une tolérance insatisfaisante (assez intolérable à extrêmement intolérable). Résultats: 2541 patients ont été inclus (hommes 48,5%; âge moyen 56,9± 15,6 ans) dont 51% avaient déjà subi une coloscopie dans le passé. La coloscopie a été jugée intolérable ou extrêmement intolérable par seulement 2,1% des patients. Trente pour cents ont présenté un score de douleur > 3 et 5,3% ont jugé l’examen extrêmement douloureux (score 8–10). 9,7% des patients n’ont reçu aucune sédation, 59,6% une sédation modérée et 30,7% une sédation profonde. 87,5% des patients accepteraient de subir une deuxième coloscopie dans les mêmes conditions. Les OR suivants (IC 95%) ont été trouvés pour la douleur: type de sédation: sédation profonde OR 1,0; sédation modérée OR 22,0 (10,0–48,2); aucune sédation OR 42,2 (18,3–97,3). Sexe: hommes OR 1,0, femmes OR 1,84 (1,52–2,24). Age: moins de 45 ans OR 1,0, 45–64 ans OR 0,68 (0,51–0,92), > 65 ans OR 0,42 (0,27–0,64). ASA: I ou II OR 1,0, III-V OR 1,21 (0,93–1,58). Durée: OR 1,05 (1,03–1,07) par minute supplémentaire. Fluoroscopie: non OR 1,9, oui OR 1,63 (1,08–2,46). Sténose: non OR 1,0, oui OR 1,94 (1,05–3,59); en dehors de la sténose, les autres diagnostics endoscopiques n’ont pas eu d’effet sur la douleur. Les OR pour une tolérance insatisfaisante ont été 1,0 pour une sédation profonde, 6,0 (2,2–15,9) pour une sédation modérée et 5,6 (2,4–12,9) pour une absence de sédation. 17,2% des patients (51,6% de ceux avec sédation profonde) étaient amnésiques par rapport à la tolérance. Conclusion: Une sédation plus profonde se traduit par une meilleure tolérance de la coloscopie avec moins de douleurs. La tolérance a été meilleure chez les hommes et les patients âgés de plus de 45 ans. Les examens difficiles et prolongés ont été moins bien tolérés. La plupart des patients auraient été d’accord de subir une autre coloscopie dans les mêmes conditions.
Comorbidities, mortality and causes of death among patients with tuberculosis in Denmark 1998–2010: a nationwide, register-based case–control study
Authors: Andreas Fløe, Ole Hilberg, Christian Wejse, Rikke Ibsen, Anders Løkke
Journal: Thorax (2017)

Objective To evaluate the impact of comorbidities, age and clinical presentation of TB on mortality among Danish patients with TB. Methods Danish patients with an ICD-10 (International Statistical Classification of Diseases and Related Health Problems 10th Revision) diagnosis of TB in 1998–2010 were identified in the National Patient Registry and matched with controls (1:4) on age, gender, civil status and geography. Comorbid diagnoses up to 3 years before and after TB diagnosis or enrolment as control as well as survival data were obtained from national databases Results We included 8433 cases and 33 707 controls. Respiratory diseases were the most common comorbidities among cases (12.4% of cases, 3.8% of controls (p&lt;0.001)). Overall HR of death was 2.45 (2.31; 2.59). Relative mortality was especially increased among younger adults (HR 8.70 (95% CI 5.53 to 13.69) among the 30 to 39-year-olds). While overall mortality increased with Deyo-Charlson comorbidity (DCC) score, relative mortality among cases was highest in the low-DCC group. Additionally, male gender, low income and central nervous system TB were risk factors for death among TB cases. The most common cause of death in both groups was non-lung cancers, among TB cases followed by COPD, TB and lung cancer, all being significantly more common among TB cases. Conclusion In Denmark, TB carries substantial mortality. Among those who die, 12% are reported to die from TB. A high relative mortality among younger adults underscores the importance of continually targeting high-risk TB groups in low-incidence countries.