tbuckley/cabot-search huggingface dataset:
AB1444-HPR Understanding fatigue burden and coping strategies in rheumatoid arthritis using qualitative research
Authors: C Zhang, Y. Shaw, B. Shakley, L. Ferri, K. Michaud, D. McDonald, T.A. Simon
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Fatigue is a major symptom of RA but is under-represented when considering an appropriate treatment and in the measurement of disease activity. At the same time, patients' perspectives on fatigue in the overall context of their RA and life have not been studied in detail before. To understand that perspective, we aimed to explore patients' lived experience with RA-related fatigue. <h3>Objectives</h3> We explored the narratives of patients with RA and their discourse on RA-related fatigue to assess the burden of disease and coping strategies. <h3>Methods</h3> Semi-structured interviews were conducted with adult patients with RA living in two geographical regions in the United States. Interviewees were asked to discuss their experiences with diagnosis, symptoms, physical and social limitations, coping with challenges, treatment and healthcare providers. The interviews were audio-recorded and transcribed verbatim. Transcripts were analysed for themes related to the burden of RA-related fatigue and coping strategies. <h3>Results</h3> Eighteen patients were interviewed, with ages ranging from 27 to 80 years and RA duration ranging from 4 to 40 years. Four themes emerged around the impact of RA-related fatigue, fatigue in context of RA symptoms, coping strategies and coping success (table 1). <h3>Conclusions</h3> Fatigue is a major concern for patients with RA and can be more debilitating than pain. A patient's constant battle with fatigue can have physical, mental and emotional consequences. <h3>Disclosure of Interest</h3> C. Zhang Grant/research support from: Bristol-Myers Squibb, Employee of: LIFT1428, Y. Shaw Grant/research support from: Bristol-Myers Squibb, B. Shakley Grant/research support from: Bristol-Myers Squibb, L. Ferri Shareholder of: Bristol-Myers Squibb, Employee of: Bristol-Myers Squibb, K. Michaud Grant/research support from: Bristol-Myers Squibb, Pfizer and Rheumatology Research Foundation, Employee of: University of Nebraska Medical Centre and National Data Bank for Rheumatic Diseases, D. McDonald Grant/research support from: Bristol-Myers Squibb, T. Simon Shareholder of: Bristol-Myers Squibb, Employee of: Bristol-Myers Squibb
Association of MICA and MICB polymorphisms with the susceptibility of leukemia in Korean patients
Authors: In-Cheol Baek, Dong-Hwan Shin, Eun-Jeong Choi, Hyoung-Jae Kim, Jae-Ho Yoon, Byung-Sik Cho, Yoo-Jin Kim, Seok Lee, Woo-Sung Min, Hee-Je Kim, Tai-Gyu Kim
Journal: Blood Cancer Journal (2018)
OP0073 Central sensitisationpredicts fatigue independently of musculoskeletal pain
Authors: K.L. Druce, J. McBeth
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Fatigue is a common musculoskeletal (MSK) pain comorbidity that is associated with increased healthcare use and poor quality of life. Central sensitisation (CS), the amplification of sensory input across multiple systems, has been associated with MSK pain. It has been hypothesised that similar mechanisms may explain the co-occurrence of fatigue, but data are conflicting. <h3>Objectives</h3> To test the hypothesis that CS was associated with the presence of fatigue, and to establish whether the relationship was independent of the relationship between MSK pain and fatigue. <h3>Methods</h3> 2455 participants in a prospective cohort study completed a baseline questionnaire collecting data on fatigue (Chalder Fatigue Scale, score 0–33 (CFQ); pain (body map, score range 0–44); demographics (date of birth, sex); Rapid Assessment of Physical Activity (RAPA); analgesic use; and mental health (Hospital Anxiety and Depression (HAD) scale). During a clinic visit a random sample of participants (n=290, 11.8%) had a wind-up ratio test (the perceived intensity of a single 256mN pinprick/intensity of a series of 10 pinpricks) at the thenar eminence of the right hand (WUR-H) and dorsum of the left foot (WUR-F) to assess CS, and bioelectric impedance (Tanita BC-418 Segmental Body Composition Analyzer) to determine proportion body fat. All participants were followed up 12 months later, at which time they completed the CFQ. Linear regression, with inverse probability sampling weights, tested the relationship between WUR at baseline and CFQ at 12 months, adjusted for baseline CFQ, demographics, lifestyle factors, HAD and in a final model baseline MSK pain. Results are expressed as beta coefficients with p values. <h3>Results</h3> The median (IQR) WUR-H and WUR-F were similar (2.4 (1.5, 3.8) and 2.5 (1.6, 4.0) respectively), did not differ by sex but were significantly lower in older people. After adjusting for age and sex, WUR-H (β=0.17, p=0.00) and WUR-F (0.18, 0.00) predicted CFQ at follow-up. In a fully adjusted model, WUR-H (Model 1: 0.13, 0.00) and WUR-F (Model 2: 0.13, 0.00) predicted CFQ at follow-up, independently of baseline MSK pain. Independent predictors of CFQ were age, MSK pain, depression, anxiety, physical activity and body fat (table 1). <h3>Conclusions</h3> Fatigue is predicted by CS, independently of the presence of MSK pain. For those seeking to treat fatigue, the potential benefit of interventions which reduce sensitisation should be investigated. <h3>Acknowledgements</h3> J.Anderson, M. Mulvey, A. Rashid <h3>Disclosure of Interest</h3> None declared
Endothelial cells in the innate response to allergens and initiation of atopic asthma
Authors: Kewal Asosingh, Kelly Weiss, Kimberly Queisser, Nicholas Wanner, Mei Yin, Mark Aronica, Serpil Erzurum
Journal: Journal of Clinical Investigation (2018)

Protease-activated receptor 2 (PAR-2), an airway epithelial pattern recognition receptor (PRR), participates in the genesis of house dust mite-induced (HDM-induced) asthma. Here, we hypothesized that lung endothelial cells and proangiogenic hematopoietic progenitor cells (PACs) that express high levels of PAR-2 contribute to the initiation of atopic asthma. HDM extract (HDME) protease allergens were found deep in the airway mucosa and breaching the endothelial barrier. Lung endothelial cells and PACs released the Th2-promoting cytokines IL-1α and GM-CSF in response to HDME, and the endothelium had PAC-derived VEGF-C-dependent blood vessel sprouting. Blockade of the angiogenic response by inhibition of VEGF-C signaling lessened the development of inflammation and airway remodeling in the HDM model. Reconstitution of the bone marrow in WT mice with PAR-2-deficient bone marrow also reduced airway inflammation and remodeling. Adoptive transfer of PACs that had been exposed to HDME induced angiogenesis and Th2 inflammation with remodeling similar to that induced by allergen challenge. Our findings identify that lung endothelium and PACs in the airway sense allergen and elicit an angiogenic response that is central to the innate nonimmune origins of Th2 inflammation.
OP0131 Innate lymphoid cells correlate with disease activity and bone remodelling in psoriatic arthritis
Authors: A. Soare, S. Weber, L. Maul, S. Rauber, A.M. Gheorghiu, I. Houssni, A. Kleyer, M. Luber, J. Rech, G. Schett, J. Distler, A. Ramming
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Evaluation of actual immunopathology in psoriatic arthritis (PsA) is challenging. Current composite measures approved for PsA are very useful tools to assess disease activity in clinical routine. Nonetheless, because of subjective patients' estimations that widely affect the scoring, in particular the distinction between remission and low disease activity is a common question of debate. Innate lymphoid cells (ILC) subsets may couple different aspects of PsA disease activity. <h3>Objectives</h3> To address whether PsA is associated with an altered composition of innate lymphoid cells and whether such changes are associated with disease activity and structural damage in PsA. <h3>Methods</h3> 124 patients satisfying the Classification Criteria for Psoriatic Arthritis (CASPAR) and 26 healthy volunteers were enrolled in the study. Information regarding clinical features, laboratory parameters were collected and disease activity score 28 (DAS28), disease activity in psoriatic arthritis (DAPSA), minimal disease activity score (MDA) were calculated. MRI and high-resolution peripheral CT were taken and PsA MRI score (PsAMRIS) was assessed. Flow cytometric analysis was performed and IFNg-producing ILC1s, IL-4/IL-5-producing ILC2s and IL-17/IL-22-producing ILC3s were identified among ILCs. Multivariate linear regression and Receiver-Operating Characteristic (ROC) Curve analysis was performed using the IBM SPSS Statistics software. <h3>Results</h3> Total number of circulating ILCs were increased in PsA patients compared to healthy controls (p&lt;0,001). Linear regression analyses of the relationship between disease activity and circulating ILC counts showed that ILC2 negatively and ILC1 and ILC3 positively correlated with DAPSA score. The strongest correlation was observed when the ratio of ILC2 to ILC3 was analysed (R=-0.5709; p&lt;0.0001). ILC2/3 ratio was also reduced in patients with active psoriatic skin disease, presence of enthesitis or a history of concomitant uveitis. Extend of synovitis or tenosynovitis or presence of bone erosions or osteophytes on MRI was inversely correlated with the ILC2/3 ratio (R=-0.6753; p&lt;0.0001, R=-0.5828; p=0.0011 and p&lt;0.001 respectively). Consistently, presence of erosions and/or osteoproliferation assessed by HR-pQCT was correlated with a significant lower ILC2/3 ratio. Furthermore, ROC Curve was used to test the performance of the ILC2/3 ratio as marker in differentiating between remission and disease activity of PsA. Indeed, a cut-off 0.57 exhibited highest sensitivity (92.9%) and a 84.7% specificity in identifying remission. <h3>Conclusions</h3> The ILC2/3 ratio correlates with various facets of PsA manifestations and might be a useful tool to evaluate disease activity in PsA patients. <h3>Disclosure of Interest</h3> None declared
Acute Limited Intimal Tears of the Thoracic Aorta
Authors: Anne S. Chin, Martin J. Willemink, Aya Kino, Virginia Hinostroza, Anna M. Sailer, Michael P. Fischbein, R. Scott Mitchell, Gerald J. Berry, D. Craig Miller, Dominik Fleischmann
Journal: Journal of the American College of Cardiology (2018)

Limited intimal tears (LITs) of the aorta (Class 3 dissection variant) are the least common form of aortic pathology in patients presenting with acute aortic syndrome (AAS). LITs are difficult to detect on imaging and may be underappreciated. This study sought to describe the frequency, pathology, treatment, and outcome of LITs compared with other AAS, and to demonstrate that LITs can be detected pre-operatively by contemporary imaging. The authors retrospectively reviewed 497 patients admitted for 513 AAS events at a single academic aortic center between 2003 and 2012. AAS were classified into classic dissection (AD), intramural hematoma, LIT, penetrating atherosclerotic ulcer, and rupturing thoracic aortic aneurysm. The prevalence, pertinent risk factors, and detailed imaging findings with surgical and pathological correlation of LITs are described. Management, early outcomes, and late mortality are reported. Among 497 patients with AAS, the authors identified 24 LITs (4.8% of AAS) in 16 men and 8 women (17 type A, 7 type B). Patients with LITs were older than those with AD, and type A LITs had similarly dilated ascending aortas as type A AD. Three patients presented with rupture. Eleven patients underwent urgent surgical aortic replacement, and 2 patients underwent endovascular repair. Medial degeneration was present in all surgical specimens. In-hospital mortality was 4% (1 of 24), and in total, 5 patients with LIT died subsequently at 1.5 years (interquartile range [IQR]: 0.3 to 2.5 years). Computed tomography imaging detected all but 1 LIT, best visualized on volume-rendered images. LITs are rare acute aortic lesions within the dissection spectrum, with similar presentation, complications, and outcomes compared with AD and intramural hematoma. Awareness of this lesion allows pre-operative diagnosis using high-quality computed tomography angiography.
Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis
Authors: Jessica M. Scott, Emily C. Zabor, Emily Schwitzer, Graeme J. Koelwyn, Scott C. Adams, Tormod S. Nilsen, Chaya S. Moskowitz, Konstantina Matsoukas, Neil M. Iyengar, Chau T. Dang, Lee W. Jones
Journal: Journal of Clinical Oncology (2018)

Purpose To evaluate the effects of exercise therapy on cardiorespiratory fitness (CRF) in randomized controlled trials (RCTs) among patients with adult-onset cancer. Secondary objectives were to evaluate treatment effect modifiers, safety, and fidelity. Methods A systematic search of PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Library was conducted to identify RCTs that compared exercise therapy to a nonexercise control group. The primary end point was change in CRF as evaluated by peak oxygen consumption (VO 2peak ; in mL O 2 × kg −1 × min −1 ) from baseline to postintervention. Subgroup analyses evaluated whether treatment effects differed as a function of exercise prescription (ie, modality, schedule, length, supervision), study characteristics (ie, intervention timing, primary cancer site), and publication year. Safety was defined as report of any adverse event (AE); fidelity was evaluated by rates of attendance, adherence, and loss to follow-up. Results Forty-eight unique RCTs that represented 3,632 patients (mean standard deviation age, 55 ± 7.5 years; 68% women); 1,990 (55%) and 1,642 (45%) allocated to exercise therapy and control/usual care groups, respectively, were evaluated. Exercise therapy was associated with a significant increase in CRF (+2.80 mL O 2 × kg −1 × min −1 ) compared with no change (+0.02 mL O 2 × kg −1 × min −1 ) in the control group (weighted mean differences, +2.13 mL O 2 × kg −1 × min −1 ; 95% CI, 1.58 to 2.67; I 2 , 20.6; P &lt; .001). No statistical significant differences were observed on the basis of any treatment effect modifiers. Thirty trials (63%) monitored AEs; a total of 44 AEs were reported. The mean standard deviation loss to follow-up, attendance, and adherence rates were 11% ± 13%, 84% ± 12%, and 88% ± 32%, respectively. Conclusion Exercise therapy is an effective adjunctive therapy to improve CRF in patients with cancer. Our findings support the recommendation of exercise therapy for patients with adult-onset cancer.
Conventional and combination topical photodynamic therapy for basal cell carcinoma: systematic review and meta-analysis
Authors: N.J. Collier, A.K. Haylett, T.H. Wong, C.A. Morton, S.H. Ibbotson, K.E. McKenna, R. Mallipeddi, H. Moseley, D. Seukeran, K.A. Ward, M.F. Mohd Mustapa, L.S. Exton, A.C. Green, L.E. Rhodes
Journal: British Journal of Dermatology (2018)

Topical photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC).To compare efficacy, cosmesis and tolerability of PDT for BCC with alternative treatments.MEDLINE, PubMed, Embase and CENTRAL databases were searched from inception until 1 September 2017. Included studies were randomized controlled trials (RCTs) of PDT for nodular (n) and superficial (s) BCC reporting at least one of the following outcomes: clearance at 3 months and sustained at 1 or 5 years; recurrence at ≥ 1 year; cosmesis; adverse events; tolerability.From 2331 search results, 15 RCTs (2327 patients; 3509 BCCs) were included. PDT efficacy (5-year sustained clearance) was high but inferior to excisional surgery [nBCC pooled risk ratio (RR) 0·76; 95% confidence interval (CI) 0·63-0·91], and without re-treatment of partially responding lesions, was modestly inferior to imiquimod (sBCC: RR 0·81; 95% CI 0·70-0·95) and similar to fluorouracil (sBCC: RR 0·88; 95% CI 0·75-1·04). Five-year sustained clearance was inferior with conventional vs. fractionated PDT (sBCC: RR 0·76; 95% CI 0·68-0·84). PDT cosmesis was superior to surgery (sBCC: RR 1·68, 95% CI 1·32-2·14; nBCC: RR 1·82, 95% CI 1·19-2·80) and cryosurgery (BCC: RR 3·73, 95% CI 1·96-7·07), and without re-treatment of partially responding lesions was similar to imiquimod (sBCC: RR 1·01, 95% CI 0·85-1·19) and fluorouracil (sBCC: RR 1·04, 95% CI 0·88-1·24). Peak pain was higher but of shorter duration with PDT than topical treatments. Serious adverse reactions were rarer with PDT than imiquimod (sBCC: RR 0·05, 95% CI 0·00-0·84) and fluorouracil (sBCC: RR 0·11, 95% CI 0·01-2·04). Combination PDT regimens demonstrated reduced recurrence and improved cosmesis; however, results from these small studies were often nonsignificant.PDT is an effective treatment for low-risk BCC, with excellent cosmesis and safety. Imiquimod has higher efficacy than single-cycle PDT but more adverse effects. Highest efficacy is with excisional surgery. Fractionated and combination PDT options warrant further study.
Abstract 14081: Preservation of Myocardial Cotractility During Acute Hypoxia With OMX, a Novel Oxygen Delivery Biotherapeutic
Authors: Jason Boehme, Natacha LeMoan, Rebecca J Kameny, Alexandra Loucks, Michael Johengen, Amy Lesneski, Wenhui Gong, Youping He, Tina Davis, Sanjeev Datar, Jeffrey Fineman, Ana Krtolica, Emin Maltepe
Journal: Circulation (2016)

Introduction:  The heart has the highest oxygen consumption per tissue mass of any organ. During acute hypoxia, myocardial O 2  consumption is further elevated as the heart attempts to preserve systemic O 2  delivery by increasing heart rate. This exposes the heart to potential ischemic stress, myocardial dysfunction and cardiac failure. Omniox, Inc. has developed a stable, well characterized and easily administered agent, OMX, that belongs to the oxygen-carrying protein family, H-NOX, and is derived from a thermostable protein originating from the thermophilic bacterium, Thermoanaerobacter tengcongensis. OMX restores physiologic oxygen levels in oxygen-deprived tissues, but does not hyper-oxygenate tissues that have physiologic levels of oxygen. Additionally, unlike previous hemoglobin-based oxygen carriers whose development was blocked by the FDA from further development due to their vasoconstrictive effects, OMX does not scavenge nitric oxide.   Hypothesis:  OMX will preserve myocardial contractility in the setting of global hypoxia.   Methods:  Juvenile lambs (age 4-6 weeks) were sedated, mechanically ventilated, and instrumented to measure vascular pressure and flow. Admittance catheters were inserted into the left and right ventricle to perform pressure-volume (PV) loop analysis. Systemic hypoxia was induced by ventilating the lambs with 10% oxygen for one hour. Fifteen minutes into hypoxia, the lambs received OMX (200 mg/kg IV) or vehicle (n=5 per group).   Results:  Acute hypoxia induced a significant increase in HR, PBF, PVR, and a decrease in systemic PaO2 (p value  p  value    Conclusions:  OMX represents a promising novel oxygen delivery biotherapeutic for the preservation of myocardial contractility in the setting of acute hypoxia.
AB0408 Analysis of the correlation of composite indicators of activity of the disease and the concordance between the different states of activity in patients with rheumatoid arthritis
Authors: T. fontana, B. ferreira althoff, C. janson ferreira, Y. alfaro, G. ricardo werner de castro, I. alves pereira
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis (RA) is an inflammatory joint disease of systemic involvement and varied evolution, which uses different disease evaluation scores. It is essential that these instruments be evaluated according to the disease, so that the treatment algorithms can be applied independently. <h3>Objectives</h3> To analyse a correlation of disease activity indexes (ICADs) and a concordance between different states of activity in patients with Rheumatoid Arthritis. <h3>Methods</h3> Cross-sectional study based on 100 patients of outpatient care from a multicenter prospective cohort study. Approved by CEP UNISUL. Statistical analysis by the SPSS 18.0 program, using the Pearson Correlation Coefficient and McNemar-Bowker Concordance, considering significance level p&lt;0,05. <h3>Results</h3> Majority female patients (86%), with an average age of 54 years, who were active in their jobs (53%) and had a positive rheumatoid factor in 65%. The average values of the ICADs were DAS-28 (3.6), DAS-28 PCR (3.0), SDAI (13.4), CDAI (12.5) and RADAI (3.5), respectively. Many were classified with moderate disease activity of the disease. The degree of correlation was very strong (&gt;0.8) and strong (between 0.8 and 0.6) in most ICADs and a concordance of remission DAS-28PCR ranged from 41.3% to 54.3% with the other ICADs. <h3>Conclusions</h3> The ICADs presented a strong correlation with each other, as well a level of similarities in the classification of the different degrees of activity. These results confirm that in different patients with RA, the ICADs serve to define active disease and to aid in the treatment strategy, so it is not imperative to use only a single evaluation score. <h3>References</h3> [1] Alvaro PM, Laiz A. Is DAS a Profitable Score to Be Used for Rheumatoid Arthritis Patient Follow Up?Reumatología Clínica (English Edition)2011;7(5):336–8. [2] Medeiros MMC, Oliveira BMGB, Cerqueira JVM, Quixadá RTS, Oliveira IMX. Correlação dos índices de atividade da artrite reumatoide (DAS-28 VHS, DAS28-PCR, SDAI, CDAI) e concordância dos estados de atividade da doença com vários pontos de corte numa população do nordeste brasileiro. Rev Bras Reumatol2015;55(6):477–84. [3] Gaujoux-Viala C, Mouterde G, Baillet A, Claudepierre P, Fautrel B, Le Loët X, Maillefert JF. Evaluating disease activity in rheumatoid arthritis: Which composite index is best? A systematic literature analysis of studies comparing the psychometric properties of the DAS, DAS28, SDAI and CDAI. Joint Bone Spine2012;79(2):149–55. <h3>Disclosure of Interest</h3> None declared