tbuckley/cabot-search huggingface dataset:
New International Editorial Board Members—October 1, 2018
Authors: Melina R. Kibbe
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Head and Neck Cancer Soft Tissue Radiation Necrosis—Diagnostic Challenge
Authors: Darko Pucar, Michael W. Groves, Paul Biddinger, Ramon Figueroa, Hadyn T. Williams
Journal: Clinical Nuclear Medicine (2018)

Abstract A 53-year-old man with T4aN2cM0 tongue base squamous cell carcinoma received definitive chemoradiation. FDG PET/CT at 6 weeks showed partial metabolic response with soft tissue air indicating radiation necrosis at primary site and complete response in the neck. At 9 weeks, contrasted CT showed worsening but nonenhancing ulceration, area biopsied demonstrating a minute carcinoma focus with treatment effect. At 12 weeks, PET/CT showed increased primary site uptake interpreted as disease progression; however, no viable tumor was found at salvage surgery. Because nonenhancing ulceration predicts pure radiation necrosis with no viable tumor, contrasted CT may guide treatment selection in challenging cases.
US doctors criticise CDC’s response to “mystery” polio-like disease in children
Authors: Owen Dyer
Journal: BMJ (2018)

An unexplained polio-like illness that spikes in frequency every second year seems to be on course for a new record number of cases.

The US Centers for Disease Control and Prevention (CDC) first publicised its concern about acute flaccid myelitis (AFM) two weeks ago, since which time the number of cases reported this year has climbed from 127 (62 confirmed) to 191 (72 confirmed).1 Cases have been confirmed in 24 states.

Canada also last week reported a sudden September spike in cases, raising the year’s total from fewer than five reported cases to 30.

Meanwhile, several doctors treating the disease, including four who advise the CDC on it, have criticised the agency’s response and its use of the word “mystery,” arguing that the evidence is enough to at least work …
Untangling the Role of Polycomb Complexes in Chemotherapy Resistance
Authors: Cihangir Duy, Ari Melnick
Journal: Cancer Discovery (2018)

Abstract Summary: In this issue, Maganti and colleagues described an epigenetic link between reduced abundance of Polycomb-related protein MTF2 and chemotherapy resistance in refractory acute myeloid leukemia. MTF2 deficiency impaired expression of the PRC2 complex and deposition of H3K27me3 at many genes, including the key target gene MDM2, leading to increased MDM2 expression that in turn depleted p53 and thereby conferred chemoresistance. Cancer Discov; 8(11); 1348–51. ©2018 AACR. See related article by Maganti et al., p. 1376.
Genetic Analysis of 400 Patients Refines Understanding and Implicates a New Gene in Atypical Hemolytic Uremic Syndrome
Authors: Fengxiao Bu, Yuzhou Zhang, Kai Wang, Nicolo Ghiringhelli Borsa, Michael B. Jones, Amanda O. Taylor, Erika Takanami, Nicole C. Meyer, Kathy Frees, Christie P. Thomas, Carla Nester, Richard J.H. Smith
Journal: Journal of the American Society of Nephrology (2018)

Background Genetic variation in complement genes is a predisposing factor for atypical hemolytic uremic syndrome (aHUS), a life-threatening thrombotic microangiopathy, however interpreting the effects of genetic variants is challenging and often ambiguous. Methods We analyzed 93 complement and coagulation genes in 400 patients with aHUS, using as controls 600 healthy individuals from Iowa and 63,345 non-Finnish European individuals from the Genome Aggregation Database. After adjusting for population stratification, we then applied the Fisher exact, modified Poisson exact, and optimal unified sequence kernel association tests to assess gene-based variant burden. We also applied a sliding-window analysis to define the frequency range over which variant burden was significant. Results We found that patients with aHUS are enriched for ultrarare coding variants in the CFH , C3 , CD46 , CFI , DGKE , and VTN genes. The majority of the significance is contributed by variants with a minor allele frequency of &lt;0.1%. Disease-related variants tend to occur in specific complement protein domains of FH, CD46, and C3. We observed no enrichment for multiple rare coding variants in gene-gene combinations. Conclusions In known aHUS-associated genes, variants with a minor allele frequency &gt;0.1% should not be considered pathogenic unless valid enrichment and/or functional evidence are available. VTN , which encodes vitronectin, an inhibitor of the terminal complement pathway, is implicated as a novel aHUS-associated gene. Patients with aHUS are not enriched for multiple rare variants in complement genes. In aggregate, these data may help in directing clinical management of aHUS.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation
Authors: Shanshan Zhong, Luxiao Li, Yu-Lei Zhang, Lili Zhang, Jianhong Lu, Shuyuan Guo, Ningning Liang, Jing Ge, Mingjiang Zhu, Yongzhen Tao, Yun-Cheng Wu, Huiyong Yin
Journal: Journal of Clinical Investigation (2018)

Acetaldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme detoxifying acetaldehyde and endogenous lipid aldehydes; previous studies suggest a protective role of ALDH2 against cardiovascular disease (CVD). Around 40% of East Asians carrying the single nucleotide polymorphism (SNP) ALDH2 rs671 have an increased incidence of CVD. However, the role of ALDH2 in CVD beyond alcohol consumption remains poorly defined. Here we report that ALDH2/LDLR double knockout (DKO) mice have decreased atherosclerosis compared with LDLR-KO mice, whereas ALDH2/APOE-DKO mice have increased atherosclerosis, suggesting an unexpected interaction of ALDH2 with LDLR. Further studies demonstrate that in the absence of LDLR, AMPK phosphorylates ALDH2 at threonine 356 and enables its nuclear translocation. Nuclear ALDH2 interacts with HDAC3 and represses transcription of a lysosomal proton pump protein ATP6V0E2, critical for maintaining lysosomal function, autophagy, and degradation of oxidized low-density lipid protein. Interestingly, an interaction of cytosolic LDLR C-terminus with AMPK blocks ALDH2 phosphorylation and subsequent nuclear translocation, whereas ALDH2 rs671 mutant in human macrophages attenuates this interaction, which releases ALDH2 to the nucleus to suppress ATP6V0E2 expression, resulting in increased foam cells due to impaired lysosomal function. Our studies reveal a novel role of ALDH2 and LDLR in atherosclerosis and provide a molecular mechanism by which ALDH2 rs671 SNP increases CVD.
Update 2018
Authors: Yasemin Sanli, Katherine Zukotynski, Erik Mittra, Delphine L. Chen, Helen Nadel, Ryan D. Niederkohr, Rathan M. Subramaniam
Journal: Clinical Nuclear Medicine (2018)

There are recent advances, namely, a standardized method for reporting therapy response (Hopkins criteria), a multicenter prospective cohort study with excellent negative predictive value of F-FDG PET/CT for N0 clinical neck, a phase III multicenter randomized controlled study establishing the value of a negative posttherapy F-FDG PET/CT for patient management, a phase II randomized controlled study demonstrating radiation dose reduction strategies for human papilloma virus-related disease, and Food and Drug Administration approval of nivolumab for treatment of recurrent head and neck squamous cell carcinoma.
Abstract 19271: Lack of Sufficient Pulsatile Flow in the Microvasculature May Contribute to Increased Microvascular Complications in Patients Implanted With Continuous Flow Left Ventricular Assist Devices
Authors: Barry J McDonnell, Francesco Castagna, Mark Najjar, Laura Watkeys, Maria Kearney, Melana Yuzefpolskaya, Veli Topkara, Arthur R Garan, Donna M Mancini, Hiroo Takayama, Yoshifumi Naka, Paolo C Colombo, John R Cockcroft
Journal: Circulation (2015)

Background: In patients on continuous flow left ventricular assist devices (CF-LVAD) support, low pulsatility has been implicated in the development of microvascular complications such as gastrointestinal bleeds and strokes. The aim of this study was to measure and compare the microvascular flow profiles of both CF-LVAD patients and age matched healthy controls. Methods: The cuff based Mobil-O-Graph system (IEM) was used to measure supine blood pressure (BP) in 6 patients implanted with a CF-LVAD. Using the captured brachial pressures and associated waveform, the inbuilt ARCSolver algorithm was used to calculate central systolic and diastolic pressures, augmentation index (AIx) and aortic pulse wave velocity (aPWV). Pulsatility index (PI) of the central retinal (CR) and mid cerebral artery (MCA) was measured using a 12MHz linear probe with vivid-Q ultrasound and 2MHz transcranial Doppler ultrasound, respectively. Similar measurements were recorded in 13 healthy, age, mean pressure and aPWV matched controls. Results: Brachial and central pulse pressures were both significantly lower in CF-LVAD patients compared to controls. In addition, PI was significantly lower in the CF-LVAD group compared to controls in the CR and MCA (Table). Conclusion: Our data provide the first evidence that pulsatile flow is significantly lower in the microcirculation of CF-LVAD patients compared to healthy controls. This lack of pulsatile flow to appropriately stimulate the endothelium and replicate normal healthy haemodynamics, may in part be responsible for the increased risk of microvascular complications in CF-LVAD patients. As this is a pilot study, more mechanistic studies assessing macro and microvascular flow haemodynamics in CF-LVAD patients are needed to understand these associations further. Table.
18F-FDG PET/CT Imaging in an Adolescent Patient With Primary Prostatic Stromal Sarcoma
Authors: Ruihe Lai, Chongyang Ding
Journal: Clinical Nuclear Medicine (2018)

Primary prostatic stromal sarcoma is an extremely rare disease that predominantly occurs in adults, accounting for only 0.1% of all prostate cancers. Prostatic stromal sarcoma is quite aggressive and can spread to lung, liver, bone, and other organs. Metastasis is one of the most important predictors for prognosis. Here, we reported a case of a 17-year-old adolescent boy diagnosed with primary prostatic stromal sarcoma through prostate biopsy, and stage was confirmed by F-FDG PET/CT.
LYMRIT 37-01: A Phase I/II Study of 177lu-Lilotomab Satetraxetan (Betalutin®) Antibody-Radionuclide-Conjugate (ARC) for the Treatment of Relapsed Non-Hodgkin's Lymphoma (NHL) — Analysis with 6-Month Follow-up
Authors: Arne Kolstad, Ulf Madsbu, Matthew Beasley, Michael Bayne, Tim M. Illidge, Noelle O'Rourke, Ingemar Lagerlöf, Roman Hajek, Wojciech Jurczak, Ella Willenbacher, Unn Merete Fagerli, Aleš Obr, Johan Blakkisrud, Ayca Muftuler Løndalen, Lisa Rojkjaer, Åse Østengen, Nils Bolstad, Signe Spetalen, Martin Erlanson, Renate Galleberg, Stine Nygaard Rudå, Harald Holte
Journal: Blood (2018)
Early Diagnosis of Skin Melanoma Metastasis by Means of Dermoscopy and Confocal Microscopy
Authors: Alessia Paganelli, Caterina Longo, Riccardo Pampena, Simonetta Piana, Stefania Borsari
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Abstract 16689: Can Cardiovascular Magnetic Resonance Identify Patients With Cardiac Sarcoidosis and Preserved Left Ventricular Ejection Fraction at Risk for Death and Sustained Ventricular Tachycardia?
Authors: Gillian Murtagh, Luke L Laffin, John F Beshai, Catherine Bonham, Karima Addetia, Amit V Patel, Zoe Yu, Francesco Maffesanti, D Kyle Hogarth, Joshua D Moss, Nadera Sweiss, Roberto M Lang, Amit R Patel
Journal: Circulation (2014)

Background: In sarcoidosis, late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is useful in detecting cardiac involvement, even when left ventricular ejection fraction (LVEF) is preserved. However, covariates associated with adverse outcomes in patients with cardiac sarcoidosis (CS) and preserved LVEF, such as death and sustained ventricular tachycardia (VT), have not been fully explored. We sought to (1) determine whether CS (as defined by presence of LGE) conferred risk of death/VT, and (2) identify risk factors for death/VT in patients with CS, independent of pulmonary disease. Methods: 218 patients with LVEF >50% and biopsy-proven extra-cardiac sarcoidosis referred for CS evaluation were identified. CMR short axis slices (1.5T Achieva, Philips) were obtained 10 min after contrast using a T1-weighted gradient echo pulse sequence. LGE was identified as regions with signal intensity >5 SD above mean of normal myocardium, and quantified as % LV mass (Virtue, Diagnosoft). Of 218 pati...
Abstract 9397: Prognostic Implications of Small Aortic Root in Aortic Valve Stenosis
Authors: Edda Bahlmann, Dana Cramariuc, Jan Minners, Mai Tone Lønnebakken, Simon Ray, Christa Gohlke-Baerwolf, Christoph A Nienaber, Nikolaus Jander, John B Chambers, Karl Heinz Kuck, Eva Gerdts
Journal: Circulation (2014)

Background: In aortic stenosis (AS), having a small aortic root influences assessment of AS severity as well as treatment strategy. The aim was to test the prognostic implications of having a small aortic root in patients with AS. Methods: Data from 1563 patients with initially asymptomatic mild-moderate AS enrolled in the Simvastatin and Ezetimibe in Aortic Stenosis study was used. Small aortic root was defined as an aortic diameter <2.60 cm at the sinotubular junction. Results: A small aortic root was found in 32.6% of patients and twice as frequent among women. In multivariate logistic regression, having small aortic root was associated with lower body height, smaller left ventricular dimensions and wall thickness, higher arterial stiffness and female sex (all p<0.05). In multivariate Cox regression analyses, having a small aortic root at baseline predicted increased cardiovascular morbidity and mortality independent of age, sex, AS severity by energy loss index, hypertension and study treatment (all p...
Vitamin D binding protein: a new biomarker of disease severity in lymphangioleiomyomatosis
Authors: Heng-Jia Liu, Elizabeth P. Henske
Journal: European Respiratory Journal (2018)

Lymphangioleiomyomatosis (LAM) is a rare destructive pulmonary neoplasm that occurs primarily in women, with onset typically during the child-bearing years. LAM is caused by hyperproliferation of abnormal smooth muscle-like "LAM cells" carrying inactivating mutations in the tumour suppressor genes encoding tuberous sclerosis complex protein 1 or 2 (TSC1 or TSC2) [1–4]. LAM cells are believed to destroy the surrounding lung parenchyma, leading to cystic lung destruction, pneumothorax and progressive lung function decline [5]. A pivotal clinical trial has demonstrated that rapamycin (sirolimus) can stabilise lung function in LAM [6]. Vitamin D binding protein is a novel biomarker of disease severity in LAM <http://ow.ly/qGdc30ml0EE>
Myeloma Patient-Derived MCL1 Point Mutations Can Influence MCL1-Inhibitor Function
Authors: Brandon Chen, Wong Pamela, Daniel Auclair, Jonathan J Keats, Paul Secrist, Justin Cidado, Adriana E. Tron, Christine M Dunham, Sagar Lonial, Joseph Opferman, Shannon M Matulis, Lawrence H. Boise
Journal: Blood (2018)
Abstract 18783: Predictive Model for High-Risk Coronary Artery Disease: An Analysis From PROMISE
Authors: James Jang, Sreekanth Vemulapalli, Manjushri Bhapkar, Christopher B Fordyce, Kerry L Lee, James E Udelson, Udo Hoffmann, Jean-Claude Tardif, William S Jones, Daniel B Mark, Vincent L Sorrell, Andrey Espinoza, Pamela S Douglas, Manesh R Patel
Journal: Circulation (2016)

Background: Patients with high-risk coronary artery disease (CAD) benefit from revascularization but may be difficult to identify clinically. Methods: Using the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) cohort of stable patients with suspected CAD randomized to coronary computed tomographic angiography as their initial diagnostic test (n=4520), this study categorized patients with high-risk CAD as obstructive left main, 3-vessel or 2-vessel CAD involving the proximal left anterior descending artery. Demographics, risk factors and risk scores were examined as potential predictors of high-risk CAD using stepwise logistic regression in the original cohort and 500 bootstrap samples. Restricted cubic splines were used to assess the association of continuous variables with high-risk CAD. Where relationships were non-linear, appropriate transformations were used. Discrimination was characterized using c-statistics, for which 95% confidence limits were determined using bootstrap...
Health systems thinking: A new generation of research to improve healthcare quality
Authors: Hannah H. Leslie, Lisa R. Hirschhorn, Tanya Marchant, Svetlana V. Doubova, Oye Gureje, Margaret E. Kruk
Journal: PLoS Medicine (2018)

Hannah Leslie and colleagues of the High-Quality Health Commission discuss in an Editorial the findings from their report that detail the improvements needed to prevent declines in individuals' health as the scope and quality of health systems increase. Patient-centered care at the population level, improved utility of research products, and innovative reporting tools to help guide the development of new methods are key to improved global healthcare.
Lower-Limb Amputation in Patients With Type 2 Diabetes Mellitus: Factors Predicting Risk in the FIELD Study
Authors: K Rajamani, Li L-P., Y A Kesaniemi, M Voysey, D Hunt, P Drury, M C D'Emden, P G Colman, Taskinen M-R., A C Keech, Investigators Fields.
Journal: Circulation (2009)
Comment on: ‘Lupus Low Disease Activity State (LLDAS) attainment discriminates responders in a systemic lupus erythematosus trial: post-hoc analysis of the Phase IIb MUSE trial of anifrolumab’ by Eric Morand et al
Authors: David Isenberg
Journal: Annals of the Rheumatic Diseases (2018)

I read with great interest the paper by Eric Morand and colleagues1 reporting on the utility of the Lupus Low Disease Activity State attainment using a useful form of discrimination in the phase IIb MUSE …
Abstract 18741: Achievement of Guideline-Directed Medical Therapy in Stable Ischemic Heart Disease Patients With and Without Chronic Kidney Disease
Authors: Heather Stahura, Efstratios Koutroumpakis, Elvira O Gosmanova, Stephanie Jou, Edward Philbin, William E Boden, Radmila Lyubarova
Journal: Circulation (2017)

Introduction: The prevalence of coronary artery disease (CAD) is increased significantly in patients with chronic kidney disease (CKD). There is a paucity of data on whether guideline-directed medical therapy (GDMT) is adequately implemented in the CAD patients with CKD. Hypothesis: Stable ischemic heart disease (SIHD) patients with CKD may be inadequately treated due to complexity of CKD management coupled with the necessity of drug adjustment and discontinuation when glomerular filtration rate (GFR) declines. To test this hypothesis, we compared rates of implementation of GDMT in SIHD patients with and without CKD. Methods: A retrospective cross-sectional study of 462 consecutive patients with SIHD was conducted between 01/2014 and 12/2015. CKD was defined as estimated GFR of < 60 ml/min/1.73m,2 based on MDRD equation, while non-CKD was defined as estimated GFR ≥60 ml/min/1.73m2. We examined the likelihood of achieving GDMT targets in patients with (n=169) and without CKD (n=293), using both univariate ...
Restricted fluid resuscitation in suspected sepsis associated hypotension (REFRESH): a pilot randomised controlled trial
Authors: Stephen P. J. Macdonald, Gerben Keijzers, David McD Taylor, Frances Kinnear, Glenn Arendts, Daniel M. Fatovich, Rinaldo Bellomo, David McCutcheon, John F. Fraser, Juan-Carlos Ascencio-Lane, Sally Burrows, Edward Litton, Amanda Harley, Matthew Anstey, Ashes Mukherjee
Journal: Intensive Care Medicine (2018)
Medicine should have a part time entry route, says head of Health Education England
Authors: Abi Rimmer
Journal: BMJ (2018)

Candidates with healthcare related degrees should be able to complete a medical degree while continuing to work, the chief executive of Health Education England (HEE) has said.

Speaking to The BMJ after a Westminster Health Conference event on 25 October, Ian Cumming said, “I want us to find a part time route to medicine. We want to be able to offer people who have got degrees in other healthcare related degrees—be that pharmacy or physiotherapy, nursing or clinical science—the opportunity to become a doctor without necessarily having to leave and go full time to medical school.”

He said that any part time course would have to achieve the high standards of full time medical …
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens
Authors: Michael S. Haney, Christopher J. Bohlen, David W. Morgens, James A. Ousey, Amira A. Barkal, C. Kimberly Tsui, Braeden K. Ego, Roni Levin, Roarke A. Kamber, Hannah Collins, Andrew Tucker, Amy Li, Daan Vorselen, Lorenzo Labitigan, Emily Crane, Evan Boyle, Lihua Jiang, Joanne Chan, Esther Rincón, William J. Greenleaf, Billy Li, Michael P. Snyder, Irving L. Weissman, Julie A. Theriot, Sean R. Collins, Ben A. Barres, Michael C. Bassik
Journal: Nature Genetics (2018)
Naturally occurring nanotube with surface modification as biocompatible, target-specific nanocarrier for cancer phototherapy
Authors: Luo-Yuan Li, Yi-Ming Zhou, Rong-Yao Gao, Xiao-Chen Liu, Hui-Hui Du, Jia-Ling Zhang, Xi-Cheng Ai, Jian-Ping Zhang, Li-Min Fu, Leif H. Skibsted
Journal: Biomaterials (2018)
Abstract 15625: Exosomal miR-106a-363 Cluster From the Hypoxic Human iPSC-derived Cardiomyocytes Restore the Autologous Ischemic Cardiomyocytes
Authors: Ji Hye Jung, Michelle Santoso, Phillip Yang
Journal: Circulation (2017)

Introduction: Induced pluripotent stem cells (iPSCs) and iPSC-derived cardiomyocytes (iCMs) are promising therapeutic approach to salvage the injured myocardium; however, there are significant obst...