tbuckley/cabot-search huggingface dataset:
Is Mesh Prophylaxis the Answer to the Prevention of Incisional Hernia?
Authors: Liane S. Feldman, Archana Ramaswamy
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Factors associated with the aggressiveness of end-of-life care for patients dying of cancer in hospitals: A nationwide cohort study.
Authors: Diogo Alexandre Martins-Branco, Silvia Lopes, Rita Canario, João Freire, Madalena Feio, Jose Ferraz Gonçalves, Gabriela Sousa, Nuno Lunet, Barbara Gomes
Journal: Journal of Clinical Oncology (2018)

68 Background: There is growing concern about the aggressiveness of cancer care at the end of life (ACCEoL). Recognizing the most affected patients is a cornerstone to improve this public health unmet need. Our aim is to identify factors associated with ACCEoL for cancer patients dying in hospitals. Methods: Cohort study of adults with ICD9CM diagnosis of cancer, who died in public hospitals in mainland Portugal (Jan'10 - Dec'15), identified from the hospital morbidity database (HMD). HMD provided individual clinical and demographic data. The primary outcome is a composite ACCEoL measure of 16 indicators, expanding an earlier framework, validated by an expert panel. We obtained hospital and area-level variables from a hospital survey and National Statistics. We used multilevel random effects logistic regression modelling (p &lt; 0.05). Results: We included 92,155 patients: median age 73 yo; 61.9% male; 53.0% metastatic. ACCEoL prevalence was 71.1%. The most prevalent indicators were &gt; 14 days in hospital (42.7%) and surgery in last 30 days (27.8%). Older age (p &lt; 0.001), breast cancer (OR 0.83; 95%CI 0.76-0.91) and metastatic disease (0.54; 0.50-0.58) were associated with less ACCEoL. In contrast, higher Deyo-Charlson comorbidity index (p &lt; 0.001), gastrointestinal (GI) and hematological malignancies (p &lt; 0.001), and death at a cancer center (1.31; 1.01-1.72) or hospital with medical oncology (MO) dept. (1.29; 1.02-1.63) were associated with higher ACCEoL. There was no association between existence of hospital palliative care services (HPCS) at the hospital of death and ACCEoL. Conclusions: Our study confirmed that clinical factors related with better understanding of disease course are associated with ACCEoL reduction. Patients with more comorbidities and GI malignancies might represent groups with complex needs, and hematological patients may be at increased risk because of unpredictable prognosis. It is important to better understand how to reduce ACCEoL in cancer centers and hospitals with MO dept.; improvement of HPCS could be an answer as these services are usually under-resourced, thus reaching few.
Sex-Related Disparities in CKD Progression
Authors: Ana C. Ricardo, Wei Yang, Daohang Sha, Lawrence J. Appel, Jing Chen, Marie Krousel-Wood, Anjella Manoharan, Susan Steigerwalt, Jackson Wright, Mahboob Rahman, Sylvia E. Rosas, Milda Saunders, Kumar Sharma, Martha L. Daviglus, James P. Lash
Journal: Journal of the American Society of Nephrology (2018)

In the United States, incidence of ESRD is 1.5 times higher in men than in women, despite men's lower prevalence of CKD. Prior studies, limited by inclusion of small percentages of minorities and other factors, suggested that men have more rapid CKD progression, but this finding has been inconsistent.In our prospective investigation of sex differences in CKD progression, we used data from 3939 adults (1778 women and 2161 men) enrolled in the Chronic Renal Insufficiency Cohort Study, a large, diverse CKD cohort. We evaluated associations between sex (women versus men) and outcomes, specifically incident ESRD (defined as undergoing dialysis or a kidney transplant), 50% eGFR decline from baseline, incident CKD stage 5 (eGFR<15 ml/min per 1.73 m2), eGFR slope, and all-cause death.Participants' mean age was 58 years at study entry; 42% were non-Hispanic black, and 13% were Hispanic. During median follow-up of 6.9 years, 844 individuals developed ESRD, and 853 died. In multivariable regression models, compared with men, women had significantly lower risk of ESRD, 50% eGFR decline, progression to CKD stage 5, and death. The mean unadjusted eGFR slope was -1.09 ml/min per 1.73 m2 per year in women and -1.43 ml/min per 1.73 m2 per year in men, but this difference was not significant after multivariable adjustment.In this CKD cohort, women had lower risk of CKD progression and death compared with men. Additional investigation is needed to identify biologic and psychosocial factors underlying these sex-related differences.
Low-Dose Opioid Hyperalgesia
Authors: Judith Skillman
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The relationship of habitual diet with esophageal inflammation and integrity in eosinophilic esophagitis
Authors: Marlou L. A. de Kroon, Marijn J. Warners, Marleen T. J. van Ampting, Lucien F. Harthoorn, Arjan J. Bredenoord, Mylene van Doorn, Melanie Kok, Bram D. van Rhijn, Simone R. B. M. Eussen, Berber J. Vlieg‐Boerstra
Journal: Allergy (2018)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Much ado about Biologicals: <i>Highlights of the Master Class on Biologicals, Prague, 2018</i>
Authors: Zuzana Diamant, Susanne J. Vijverberg, Ioana Agache, Leif Bjermer, Adam Chaker, Philippe Gevaert, Peter W. Hellings, Parameswaran Nair, Liam O'Mahony, Petr Panzner, Petr Pohunek, Martina Vašáková
Journal: Allergy (2018)
Correction to: Polymyxin B-immobilized hemoperfusion and mortality in critically ill adult patients with sepsis/septic shock: a systematic review with meta-analysis and trial sequential analysis
Authors: Tomoko Fujii, Riki Ganeko, Yuki Kataoka, Toshi A. Furukawa, Robin Featherstone, Kent Doi, Jean-Louis Vincent, Daniela Pasero, René Robert, Claudio Ronco, Sean M. Bagshaw
Journal: Intensive Care Medicine (2018)
Development of a new brain metastates model in the nude rat
Authors: Frits Thorsen, Paal-Henning Pedersen, Hrvoje Miletic, Rolf Bjerkvig, Jian Wang
Journal: Cancer Research (2008)

401  Introduction:  Animal models are of vital importance in the study of cancer development and progression. The relevance of each model depends on how closely it mimics the histology, physiological parameters, biochemical pathways and metastatic spread of the original tumour. Orthotopic xenografts of human tumours into immunodeficient animals may show similar histological features and metastatic spread as observed in the original tumour. Here we describe a new rat/tumour model, where brain metastases directly harvested from cancer patients are xenografted into the brains of immunocompromised rats.  Materials and Methods:  Brain metastases were collected during operation, minced into small fragments, and stereotactically implanted into brains of immunodeficient (Rowett rnu/rnu) rats. The animals where followed by MR imaging, and T1 weighted (T1w) images (with/without contrast enhancement) as well as T2 weighted (T2w) MR images were acquired using a 7T small animal MR scanner. As tumours developed, diffusion weighted images were also acquired. The rats where sacrificed upon signs of illness, and detailed histological examinations of the tumours were performed.  Results and Discussion:  Brain metastases from several different patients were implanted (primary: colon, ovarian, lung), and all developed tumours in the rat brain after 6-32 weeks. T1w images after contrast injections of colon metastases and ovarian metastases in the rat brains showed similar contrast enhancement to the clinical pictures. T2w images displayed extensive edema inside the tumour area. Diffusion weighted imaging of the colon metastases in the rat brains further verified the increased intratumoral edema, and the apparent diffusion constant increased from 0.682*10-3 mm2/sec (control animals) to 0.947*10-3 mm2/sec (p
Management of severe pregnancy sickness and hyperemesis gravidarum
Authors: Caitlin R Dean, Manjeet Shemar, Gillian A U Ostrowski, Rebecca C Painter
Journal: BMJ (2018)

### What you need to know

Nausea and vomiting in pregnancy (NVP) affects around 70% of pregnancies. It is mild for around 40% of women, moderate for 46%, and severe for 14%.1 Mild to moderate NVP usually resolves in the second trimester, with 90% of cases resolving by 20 weeks.2 It does not generally require treatment. By contrast, hyperemesis gravidarum (HG) is a complication of pregnancy rather than a normal part of it and occurs in around 1.5% of pregnancies.3 It is not unusual for HG to persist throughout pregnancy.45 The psychosocial burden of HG can be heavy for women and their families, but effective and holistic treatment may reduce this.67

Historically, the aetiology of HG was poorly understood and it was thought to be caused by endocrine, infectious, psychosocial, and hereditary factors.4 However, recent studies in twins showed that severity and duration of NVP are highly genetic.8 Family history of HG leads to a threefold increased chance of the condition occurring among offspring.9 A genome wide association study found that genetic variants of the growth and differentiation factor 15 protein (GDF15) and insulin like growth factor binding protein 7 (IGFBP7) genes were strongly associated with NVP and HG.10 In another study, women with severe NVP symptoms who were …
Erratum to ‘Incidence, predictors and clinical management of hyperkalaemia in new users of mineralocorticoid receptor antagonists’ [Eur J Heart Fail 2018;20:1217–1226]
Authors: Marco Trevisan, Pietro de Deco, Hairong Xu, Marie Evans, Bengt Lindholm, Rino Bellocco, Peter Barany, Tomas Jernberg, Lars H. Lund, Juan J. Carrero
Journal: European Journal of Heart Failure (2018)
Examining the intersection of palliative care, hospice, and concurrent care in Veterans Affairs (VA).
Authors: Kathleen Elizabeth Bickel, Cari Levy, Emily Corneau, Susan C Miller, Vincent Mor
Journal: Journal of Clinical Oncology (2018)

139 Background: The VA advocates for both palliative care and concurrent care (hospice care and cancer-directed treatment). Studies indicate that these policies have increased hospice use and have improved family-reported outcomes and other quality metrics. However, little is known about how palliative care, hospice care and concurrent care may interact to obtain these outcomes. Methods: This was a retrospective cohort study of veterans dying with stage IV non-small cell lung cancer in 2012. VA and Medicare administrative data were used to identify the cohort, chemotherapy and radiation use, hospitalizations, hospice use and length of stay (LOS). Palliative care use was determined by VA data only. Analyses included descriptive statistics, chi-square and analysis of variance. Results: Of the 1763 veterans, 850 (48.2%) received both palliative care and hospice, 392 (22.2%) received hospice only, 241 (13.7%) received palliative care only and 280 (15.9%) received neither. Receipt of cancer-directed treatment or hospitalization in the last 30 days of life was significantly different across these groups (p &lt; 0.0001) and was highest at 65% (182/280) in the neither palliative care or hospice group. In the remaining groups, rates of cancer-directed treatment or hospitalization in the last 30 days were: 39.4% (95/241) in palliative care only, 29.3% (115/392) in hospice only and 23% (198/850) with both palliative care and hospice. Concurrent care was received by 314 veterans (17.8%), 275 also receiving palliative care. Among veterans receiving palliative care and Medicare hospice, concurrent care did not alter hospice utilization rates or LOS: 36.4% (100/275), LOS mean 22.3, median 16.5, range 1-97 and 37.2% (214/575), LOS mean 20.1, median 13, range 1-94, for concurrent care and non-concurrent care respectively. Conclusions: The rates of cancer-directed treatment or hospitalization in the last 30 days of life appeared to be reduced in a continuum from receipt of neither hospice nor palliative care, to receipt of palliative care or hospice alone, followed by receipt of both together. Concurrent care use was facilitated by palliative care without impacting Medicare hospice use or LOS in palliative care recipients.
Recurrent Genomic Aberrations of D-Type Cyclins Are Therapeutic Targets of CDK4/6 Inhibitors in t(8;21) and MLL-Rearranged Acute Myeloid Leukemia
Authors: Hidemasa Matsuo, Kenichi Yoshida, Kazutaka Fukumura, Kana Nakatani, Yuki Noguchi, Saho Takasaki, Mina Noura, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Ai Okada, Yasuhito Nannya, June Takeda, Hiroo Ueno, Norio Shiba, Genki Yamato, Nobutaka Kiyokawa, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Yasuhide Hayashi, Hiroyuki Mano, Satoru Miyano, Yasuhiko Kamikubo, Seishi Ogawa, Souichi Adachi
Journal: Blood (2018)
Abstract 15415: TEMPO: A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose Ranging, Parallel Group Study to Evaluate the Effect of Eleclazine on Ventricular Arrhythmia in Subjects With Implantable Cardioverter-Defibrillator or Cardiac Resynchronization Therapy-Defibrillator
Authors: Sergio F Cossu, Jacek Wilczek, Arthur Oreziak, Bela Merkely, Ramin A Ebrahimi, Gabriel Brooks, Carol A Satler, Carl M Valentine
Journal: Circulation (2017)

Introduction: TEMPO was designed to determine the efficacy, safety & tolerability of two doses of late sodium channel blocker eleclazine (ELEC) compared to placebo (PBO) in subjects with implantabl...
Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B
Authors: Xuexia Zhou, Run Wang, Xuebing Li, Lin Yu, Dan Hua, Cuiyun Sun, Cuijuan Shi, Wenjun Luo, Chun Rao, Zhendong Jiang, Ying Feng, Qian Wang, Shizhu Yu
Journal: Journal of Clinical Investigation (2018)

Abnormal alternative splicing (AS) caused by alterations to splicing factors contributes to tumor progression. Serine/arginine splicing factor 1 (SRSF1) has emerged as a key oncodriver in numerous solid tumors, leaving its roles and mechanisms largely obscure in glioma. Here, we demonstrate that SRSF1 is increased in glioma tissues and cell lines. Moreover, its expression was correlated positively with tumor grade and Ki-67 index, but inversely with patient survival. Using RNA-Seq, we comprehensively screened and identified multiple SRSF1-affected AS events. Motif analysis revealed a position-dependent modulation of AS by SRSF1 in glioma. Functionally, we verified that SRSF1 promoted cell proliferation, survival, and invasion by specifically switching the AS of the myosin IB (MYO1B) gene and facilitating the expression of the oncogenic and membrane-localized isoform, MYO1B-fl. Strikingly, MYO1B splicing was dysregulated in parallel with SRSF1 expression in gliomas and predicted the poor prognosis of the patients. Further investigation revealed that SRSF1-guided AS of the MYO1B gene increased the tumorigenic potential of glioma cells through the PDK1/AKT and PAK/LIMK pathways. Taken together, we identify SRSF1 as an important oncodriver that integrates AS control of MYO1B into promotion of gliomagenesis and represents a potential prognostic biomarker and target for glioma therapy.
Abstract P160: Relationship of Physical Function and Quality of Life in Elderly Patients With Acute Decompensated Heart Failure: The Rehabilitation Therapy in Older Acute Heart Failure Patients (The REHAB-HF Trial)
Authors: Amer I Aladin, David Whellan, Robert Mentz, Gordon Reeves, Pamela Duncan, Diego Malaver, Paul Rosenberg, Kathleen Fitzgerald, Dalane Kitzman
Journal: Circulation (2018)

Introduction: Older patients with acute decompensated heart failure (ADHF) have impaired physical function (PF) and reduced quality of life (QOL). However, the relationship between impairments in PF and QOL are unknown but relevant to clinical practice and design of targeted intervention trials in this high-risk population. Methods: We assessed 202 consecutive patients hospitalized with ADHF in the multicenter Rehabilitation Therapy in Older Acute HF Patients (REHAB-HF) Trial. Standard measures of PF included the Short Physical Performance Battery (SPPB), a validated PF outcome measure in frail elderly, and 6-minute Walking Distance (6MWD). QOL was assessed by Kansas City Cardiomyopathy Questionnaire (KCCQ). Pearson’s correlation statistics examined associations between PF and QOL. Stepwise regressions were performed to identify independent predictors of QOL including PF measures, demographics, and disease severity indicators (NYHA class, previous hospitalizations, duration of current hospitalization, and number of HF signs and symptoms). Results: Participants were 72±7.5 years, BMI 33.2±8.8 kg/m 2 , 54% women, 52% non-white, 52% with reduced ejection fraction, and 44% with previous hospitalizations within 6 months. Participants had marked deficits in PF (SPPB 6.0±2.5 units, 6MWD 185±99 meters) and low QOL (KCCQ Physical Limitation Score (PLS) 47.3±23.8). There were modest but highly significant correlations of QOL measures with SPPB, 6MWD, and number of HF symptoms and signs (Table). Using stepwise regressions, 6MWD and BMI were modest, significant independent predictors of QOL (partial r=0.18, p=0.012 and partial r=-0.27, p=0.0003, respectively), while SPPB, demographics, and HF severity indicators were not. Conclusion: In older, hospitalized ADHF patients, PF and QOL are both severely impaired, but are only modestly related. PF and QOL assess unique domains of impairment and provide complementary information for characterizing clinically meaningful patient-oriented outcomes in ADHF.
Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis
Authors: Vivek Kasinath, Osman A. Yilmam, Mayuko Uehara, Liwei Jiang, Farideh Ordikhani, Xiaofei Li, David J. Salant, Reza Abdi
Journal: Kidney International (2018)
Idiopathic pulmonary fibrosis: unmasking cryptogenic environmental factors
Authors: Coralynn Sack, Ganesh Raghu
Journal: European Respiratory Journal (2018)

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown origin that is associated with high morbidity and mortality. In this perspective, we briefly review the current understanding of the pathophysiology of IPF and the importance of environmental triggers as a precipitant of disease. We discuss occult intrinsic and extrinsic environmental factors that affect the lung microenvironment and may contribute to the development and progression of disease. The clinical implications of this framework need to be further elucidated, because prompt identification and elimination of occult exposures may represent a novel treatment modality.
Abstract 247: CPR Backboard or No Backboard?…That is the Question!
Authors: Akira Nishisaki, Matthew R Maltese, Dana Niles, Robert M Sutton, Javier Urbano, Robert A Berg, Vinay M Nadkarni
Journal: Circulation (2010)

Objective: To determine whether use of a backboard (BB) during CPR can reduce mattress displacement, thereby allowing more of the sternal force to directly compress the chest. Methods: Epochs of 50...
Virtual stenting with simplex mesh and mechanical contact analysis for real-time planning of thoracic endovascular aortic repair
Authors: Duanduan Chen, Jianyong Wei, Yiming Deng, Huanming Xu, Zhenfeng Li, Haoye Meng, Xiaofeng Han, Yonghao Wang, Jia Wan, Tianyi Yan, Jiang Xiong, Xiaoying Tang
Journal: Theranostics (2018)

In aortic endovascular repair, the prediction of stented vessel remodeling informs treatment plans and risk evaluation; however, there are no highly accurate and efficient methods to quantitatively simulate stented vessels. This study developed a fast virtual stenting algorithm to simulate stent-induced aortic remodeling to assist in real-time thoracic endovascular aortic repair planning. Methods: The virtual stenting algorithm was established based on simplex deformable mesh and mechanical contact analysis. The key parameters of the mechanical contact analysis were derived from mechanical tests on aortic tissue (n=40) and commonly used stent-grafts (n=6). Genetic algorithm was applied to select weighting parameters. Testing and validation of the algorithm were performed using pre- and post-treatment computed tomography angiography datasets of type-B aortic dissection cases (n=66). Results: The algorithm was efficient in simulating stent-induced aortic deformation (mean computing time on a single processor: 13.78±2.80s) and accurate at the morphological (curvature difference: 1.57±0.57%; cross-sectional area difference: 4.11±0.85%) and hemodynamic (similarity of wall shear stress-derived parameters: 90.16-90.94%) levels. Stent-induced wall deformation was higher (p<0.05) in distal stent-induced new entry cases than in successfully treated cases, and this deformation did not differ significantly among the different stent groups. Additionally, the high stent-induced wall deformation regions and the new-entry sites overlapped, indicating the usefulness of wall deformation to evaluate the risks of device-induced complications. Conclusion: The novel algorithm provided fast real-time and accurate predictions of stent-graft deployment with luminal deformation tracking, thereby potentially informing individualized stenting planning and improving endovascular aortic repair outcomes. Large, multicenter studies are warranted to extend the algorithm validation and determine stress-induced wall deformation cutoff values for the risk stratification of particular complications.
SYNTAX Score in Patients With Diabetes Undergoing Coronary Revascularization in the FREEDOM Trial
Authors: Rodrigo B. Esper, Michael E. Farkouh, Expedito E. Ribeiro, Whady Hueb, Michael Domanski, Taye H. Hamza, Flora S. Siami, Lucas Colombo Godoy, Verghese Mathew, John French, Valentin Fuster
Journal: Journal of the American College of Cardiology (2018)