tbuckley/cabot-search huggingface dataset:
Somatic copy number profiling of hepatocellular carcinoma circulating tumor cells.
Authors: Colin MacDonald Court, Shuang Hou, Paul Winograd, Saeed Sadeghi, Richard S. Finn, Min Song, Fady M Kaldas, Ronald W Busuttil, Thomas Graeber, James S Tomlinson, Hsian-Rong Tseng, Vatche G Agopian
Journal: Journal of Clinical Oncology (2018)

290 Background: Copy number variations (CNVs) have shown prognostic and predictive utility in hepatocellular carcinoma (HCC) but their use from percutaneous biopsies is limited due to HCC’s significant tumor heterogeneity. We investigated the feasibility of obtaining CNV profiles from circulating tumor cells (CTCs) as a liquid biopsy for HCC. Methods: Using a microfluidic HCC-specific CTC assay, CTCs were isolated from 10 patients with HCC and low-resolution (~0.01x) whole genome sequencing performed to establish CNV profiles. Primary tumor, peritumoral liver, and germline DNA was sequenced for comparison. Results: Sequencing of 18 CTC samples (median 4 CTCs/sample) from 10 HCC patients using a low-resolution whole genome sequencing strategy (median 0.88 million reads/sample) revealed frequent copy number changes in previously reported HCC regions such as 8q amplifications and 17p deletions. Analysis of CNV profiles revealed that CTCs share a median of 80% concordance with the primary tumor and that CTCs clustered with their respective primary tumor for 9/10 samples. Sequencing of 7 different CTC samples from a single patient established the reproducibility of the assay. CTCs also demonstrated CNVs not seen in the primary tumor, some with prognostic implications. Conclusions: CNV profiling of HCC-CTCs is feasible and accurately recapitulates CNVs seen in the primary tumor. The use of CTC-derived genetic profiles as clinically relevant surrogates of HCC tumors demonstrates potential and should be explored further. [Table: see text]
SETD1A protects HSCs from activation-induced functional decline in vivo
Authors: Kathrin Arndt, Andrea Kranz, Juliane Fohgrub, Adrien Jolly, Anita S. Bledau, Michela Di Virgilio, Mathias Lesche, Andreas Dahl, Thomas Höfer, A. Francis Stewart, Claudia Waskow
Journal: Blood (2018)
PROGNOSTIC UTILITY OF PHASE CONTRAST CINE-MAGNETIC RESONANCE IMAGING OF CORONARY SINUS AFTER ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Yoshinori Kanno, Taishi Yonetsu, Yoshihisa Kanaji, Eisuke Usui, Masahiro Hoshino, Masahiro Hada, Tadashi Fukuda, Yohei Sumino, Hiroaki Ohya, Rikuta Hamaya, Tsunekazu Kakuta
Journal: Journal of the American College of Cardiology (2018)
I am interested in taking a year out of training to work as a cruise ship doctor for six months and then do some travelling. When and how should I apply for such a job? Three years after qualification? Please advise.
Authors: Alon Duby
Journal: BMJ (2005)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
INSUFFICIENT CARDIOVASCULAR RISK FACTOR CONTROL AND ADHERENCE TO RECOMMENDED LIFESTYLE AND MEDICAL THERAPIES IN PEOPLE WITH CORONARY HEART DISEASE IN 24 EUROPEAN COUNTRIES
Authors: Kornelia Kotseva, Dirk De Bacquer, Guy De Backer, Lars Ryden, Catriona Jennings, David Wood
Journal: Journal of the American College of Cardiology (2018)
Abstract 16395: Metabolic Fingerprinting of Acute Coronary Syndrome Identifies Formate as a Biomarker
Authors: Ignasi Barba, Carmen Cristobal, José A Barrabés, Elisabet Miro, JoaquÍn Alonso, David Garcia-Dorado
Journal: Circulation (2012)

Clinical data, ECG and biomarkers, in particular troponins, have proven very useful in the diagnosis and risk stratification of ACS. However, the challenge of diagnosing myocardial ischemia in the everyday clinical setting remains. Available methods have suboptimal specificity. In this study we used NMR based metabolic fingerprinting in search of new biomarkers of ACS. Serum samples from a) patients diagnosed of ACS were obtained during the acute phase (n=48) and at 6 months (n=38), 15 Q wave AMI, 13 non Q wave AMI, 20 Unstable angina in the acute and 13 Q wave AMI, 12 non Q wave AMI and 13 unstable angina and b) patients with initially suspected ACS in whom this diagnosis was later ruled out (n=14). NMR spectra were obtained at 9,4T with a CPMG pulse sequence and pattern recognition analysis was performed on SIMCA-P software. 1H NMR spectra based metabolic fingerprinting was able to differentiate the acute phase of ACS from control or chronic phase ACS patients. Discriminant analysis showed that the most important metabolites in the discriminant model were relatively elevated lipid peaks at the acute phase and higher glucose in controls and at the chronic stage. When only the aromatic part of the spectra was used, the quality of the classification improved, and it was found that the peak corresponding to formic acid was responsible for the classification. Formate peak area was measured and was found to be different between acute phase of ACS and controls or chronic phase ACS (p
ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR THERAPY PROMOTES EARLY ANGIOGENESIS AND IMPROVES MYOCARDIAL PERFUSION INHIBITING POST-INFARCT REMODELING
Authors: Stephanie L. Thorn, Daniela Tirziu, Daniel Pfau, Nicole Mikush, Jiasheng Zhang, Jennifer Renaud, Ran Klein, Robert deKemp, Xiaohong Wu, Xiaoyue Hu, Lawrence Young, Albert Sinusas
Journal: Journal of the American College of Cardiology (2018)
NHS Commissioning Board sets out criteria for CCG authorisation
Authors: Helen Jaques
Journal: BMJ (2012)

The NHS Commissioning Board has set out the criteria clinical commissioning groups (CCGs) must meet and the evidence they must submit to be authorised as statutory bodies by 2013.

CCGs will be assessed against six domains designed to provide assurance that the organisations can commission safely, responsibly manage the NHS budget, and exercise their functions in relation to improving quality, reducing health inequalities, and delivering improved outcomes within the available resources.

In their application for authorisation commissioning groups …
Mitral Valve Prolapse
Authors: E D Wigle, H Rakowski, N Ranganathan, M Silver
Journal: Annual Review of Medicine (1976)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More
Oral presentations
Authors: T Sprong, M Emonts, R Rossau, E De Meester, M Van Thielen, M Netea, C Neeleman, I Klasen, R De Groot, J Hazelzet, J Van Der Meer, J Drenth, M Van Deuren, A Loonen, W Hansen, A Jansz, H Kreeftenberg, C Bruggeman, P Wolffs, A Van Den, N Brenwald, B Walker, K Chana, M Parsons, L Peterson, C Woods, S Allen, D Pombo, A Onderdonk, O Liesenfeld
Journal: Clinical Microbiology and Infection (2010)
Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement
Authors: Jakko van Ingen, Timothy Aksamit, Claire Andrejak, Erik C. Böttger, Emmanuelle Cambau, Charles L. Daley, David E. Griffith, Lorenzo Guglielmetti, Steven M. Holland, Gwen A. Huitt, Won-Jung Koh, Christoph Lange, Philip Leitman, Theodore K. Marras, Kozo Morimoto, Kenneth N. Olivier, Miguel Santin, Jason E. Stout, Rachel Thomson, Enrico Tortoli, Richard J. Wallace, Kevin L. Winthrop, Dirk Wagner
Journal: European Respiratory Journal (2018)

Nontuberculous mycobacterial pulmonary diseases (NTM-PD) are increasingly recognised as opportunistic infections of humans. These chronic pulmonary infections have two main presentations. The first is a fibro-cavitary disease, that occurs in patients with pre-existing pulmonary diseases, such as chronic obstructive pulmonary disease, bronchiectasis, previous tuberculosis or other structural lung disease. The second presentation is a nodular-bronchiectatic disease of primarily the lingula and middle lobe that tends to affect a middle-aged and elderly female population [1]. Improving treatment outcome reporting in NTM disease: NTM-NET (@ntmnet) consensus statement on treatment outcome definitions <http://ow.ly/c6IC30iwLM4> The authors wish to thank the American Thoracic Society, European Respiratory Society, Infectious Diseases Society of America and European Society of Clinical Microbiology and Infectious Diseases for organising the two meetings during which the process leading to this statement was initiated. These organisations do not officially endorse this NTM-NET consensus statement.
The writer of <i>Bodies</i>
Authors: Sabina Dosani
Journal: BMJ (2006)

Jed Mercurio9s first television medical drama was the controversial, ground breaking <i>Cardiac Arrest</i> (written under the pseudonym John MacUre). He wrote and directed the ITV comedy-drama <i>The Grimleys</i> before creating <i>Bodies</i>, based on his first novel, which won the Royal Television Society award for best drama series of 2005. Jed9s next novel, <i>Ascent</i>, will be published in February 2007
Pulvertaft mini-fragment fixation course
Authors: Benjamin L M Way, George Murphy
Journal: BMJ (2011)

This two day course is aimed at trainees in hand surgery who are learning to manage hand fractures. In practice this means trainees in plastic and orthopaedic surgery, although the course is also attended by trauma surgeons and general surgeons from the United Kingdom and around the world.

Attendance at a course such as this is considered essential for those who want to pursue a career in plastic or hand surgery, and it shows excellent commitment to the specialty. Consultants will want to know that you have had this formal training before being happy to let you start operating on hand fractures. Although several hand fracture workshops take place in the UK, this well established course at one of the country’s best hand units is consistently recognised as giving the best training available. The …
Wheat receptor-kinase-like protein Stb6 controls gene-for-gene resistance to fungal pathogen Zymoseptoria tritici
Authors: Cyrille Saintenac, Wing-Sham Lee, Florence Cambon, Jason J. Rudd, Robert C. King, William Marande, Stephen J. Powers, Hélène Bergès, Andy L. Phillips, Cristobal Uauy, Kim E. Hammond-Kosack, Thierry Langin, Kostya Kanyuka
Journal: Nature Genetics (2018)
Spire Healthcare sees 12% rise in revenue from self pay patients in 2017
Authors: Gareth Iacobucci
Journal: BMJ (2018)

One of the UK’s largest private healthcare providers has reported a 12% rise in “self pay” revenue in the past year, as NHS rationing and pressure on waiting times prompt more patients to seek private treatment.1

Spire Healthcare, which treats patients through a variety of routes including private medical insurance, self pay, and the NHS, saw its revenues from private medical insurance decline by 1.5% in 2017. Alongside this, continued fiscal pressure in the NHS saw Spire’s revenues from treating NHS patients dip …
Junior doctor reunites Green Wing cast to support strike action
Authors: Abi Rimmer
Journal: BMJ (2016)

The cast of Green Wing have supported the fourth round of junior doctors’ industrial action from a picket line after they were contacted by a junior doctor.

Five of the cast of the Channel 4 comedy attended the picket line at Northwick Park Hospital, London, on Wednesday 6 April to show their support for the action.

Janis Burns, an anaesthetic trainee who works at the hospital, where the series was filmed, told BMJ Careers that she emailed the agents of 10 members of the cast, asking if the actors would get involved.

“At the last strike I felt that there was a little bit of apathy and people were quite demoralised and I thought about what we could do to try and improve things,” Burns said. “Working at Northwick Park I knew that Green Wing was filmed there so I decided to contact the actors and see whether they would be interested in reuniting on the picket line with junior doctors, over ten years after Green Wing was filmed. And they agreed.”

Burns said that after emailing the agents of the cast members …
Fast track graduate entry medical courses can continue, after European vote
Authors: Caroline White
Journal: BMJ (2013)

The future of UK fast track graduate entry medical courses looks assured after the European parliament decided not to redefine the minimum medical training threshold.1

The parliament decided to retain the current threshold definition in the revised directive on mutual recognition of professional qualifications. This means that basic undergraduate training will be defined as consisting of five years of study and at least 5500 hours of theoretical and practical training.

Last year an umbrella organisation of …
Use of emollients and topical glucocorticoids among adolescents with eczema: data from the population-based birth cohort BAMSE
Authors: S. Lundin, C.F. Wahlgren, A. Bergström, E.K. Johansson, E. Dahlén, N. Andersson, I. Kull
Journal: British Journal of Dermatology (2018)

Knowledge regarding how adolescents treat their eczema is sparse.To explore the use of emollients and topical glucocorticoids in adolescents with eczema in relation to sex and disease severity, and to study dispensing patterns of topical glucocorticoids.Questionnaire-based data on symptoms of eczema, eczema severity and treatment with emollients and topical glucocorticoids were obtained from 3108 adolescents in the Swedish population-based birth cohort BAMSE. Severity of reported eczema was evaluated with the BAMSE Eczema Severity Score (BESS) in a questionnaire and with the Patient-Oriented Eczema Measure in clinically examined patients with current eczema (n = 247). Information on dispensed topical glucocorticoids was obtained from the Swedish Prescribed Drug Register.In all, 10% of the adolescents reported eczema in the preceding year: 73% mild, 17% moderate and 10% severe according to BESS. Almost all used emollients, whereas use of topical glucocorticoids was reported by 55%, with no significant difference between sexes. The likelihood of treatment with emollients and topical glucocorticoids increased when the adolescents had symptoms of current eczema [adjusted odds ratio (OR) 5·95, 95% confidence interval (CI) 1·90-18·8], but not if they had more severe eczema compared with mild eczema (adjusted OR 1·57, 95% CI 0·58-4·25). Among those with reported eczema, 24% had a topical glucocorticoid dispensed in the preceding year, and among those with moderate-to-severe current eczema 24% had a dispensed potent topical glucocorticoid.This population-based study indicates that adolescents with eczema are undertreated or completely untreated, even those with severe eczema.
What happens to the foundation trainees who don’t move straight into specialty training?
Authors: Eleanor Checkley, Hannah Williams, Paul Baker
Journal: BMJ (2013)

North Western Foundation School has surveyed foundation trainees who do not go straight into specialty training. <b>Eleanor Checkley</b>, careers lead at the school, <b>Hannah Williams, and Paul Baker</b> look at why these trainees choose to take time out of training, at the support they need, and consider the potential impact on their careers
PROGNOSTIC VALUE OF LEFT VENTRICULAR DYSSYNCHRONY DETECTED BY NUCLEAR CARDIOLOGY IN PATIENTS WITH CORONARY ARTERY DISEASE
Authors: Takumi Hatta, Shunichi Yoda, Koyuru Monno, Takashi Mineki, Yasuyuki Suzuki, Naoya Matsumoto, Atsushi Hirayama
Journal: Journal of the American College of Cardiology (2018)
Diploma in critical care medicine
Authors: Kofi Nimako
Journal: BMJ (2007)

The blue spots in the CT scan show lead shots in the head as a result of a hunting accident 

Credit: GCa/SPL



FURTHER INFORMATION 

Course Team, MSc in Critical Care, Department of Anaesthetics and Intensive Care Medicine, Wales College of Medicine, Cardiff University, Cardiff CF14 4XN (029 20743215; msccritcare@cardiff.ac.uk)

Health professionals from all backgrounds who want to specialise in intensive care.

I began the course in 2005 during my senior house officer training in critical care.

I want to specialise …
I'm an SHO and I need to live my life for a while. Can I return to medicine in five years' time?
Authors: Anne Hastie
Journal: BMJ (2005)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
I am considering a career in general practice, and intend to make up my own rotation with six month SHO posts. Will stand alone posts in specialties such as paediatrics still exist with the introduction of the foundation training programme?
Authors: Kay Mohanna
Journal: BMJ (2005)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
Infective Endocarditis After Bentall Surgery
Authors: Cécile Heuzé, Laurent Lepage, Paul Loubet, Xavier Duval, Claire Cimadevilla, Constance Verdonk, Fabien Hyafil, Francois Rouzet, Phalla Ou, Patrick Nataf, Alec Vahanian, David Messika-Zeitoun
Journal: JACC. Cardiovascular imaging (2018)
Therapeutic Targeting of Sunitinib-Induced AR Phosphorylation in Renal Cell Carcinoma
Authors: Remi Adelaiye-Ogala, Nur P. Damayanti, Ashley R. Orillion, Sreevani Arisa, Sreenivasulu Chintala, Mark A. Titus, Chinghai Kao, Roberto Pili
Journal: Cancer Research (2018)

Abstract Androgen receptor (AR) plays a crucial role in the development and progression of prostate cancer. AR expression has also been reported in other solid tumors, including renal cell carcinoma (RCC), but its biological role here remains unclear. Through integrative analysis of a reverse phase protein array, we discovered increased expression of AR in an RCC patient–derived xenograft model of acquired resistance to the receptor tyrosine kinase inhibitor (RTKi) sunitinib. AR expression was increased in RCC cell lines with either acquired or intrinsic sunitinib resistance in vitro. An AR signaling gene array profiler indicated elevated levels of AR target genes in sunitinib-resistant cells. Sunitinib-induced AR transcriptional activity was associated with increased phosphorylation of serine 81 (pS81) on AR. Additionally, AR overexpression resulted in acquired sunitinib resistance and the AR antagonist enzalutamide-induced AR degradation and attenuated AR downstream activity in sunitinib-resistant cells, also indicated by decreased secretion of human kallikrein 2. Enzalutamide-induced AR degradation was rescued by either proteasome inhibition or by knockdown of the AR ubiquitin ligase speckle-type POZ protein (SPOP). In vivo treatment with enzalutamide and sunitinib demonstrated that this combination efficiently induced tumor regression in a RCC model following acquired sunitinib resistance. Overall, our results suggest the potential role of AR as a target for therapeutic interventions, in combination with RTKi, to overcome drug resistance in RCC. Significance: These findings highlight the therapeutic potential of targeting the androgen receptor to overcome RCC resistance to receptor tyrosine kinase inhibitors. Cancer Res; 78(11); 2886–96. ©2018 AACR.
Guidance document for prevention of Clostridium difficile infection in acute healthcare settings
Authors: S. Tschudin-Sutter, E.J. Kuijper, A. Durovic, M.J.G.T. Vehreschild, F. Barbut, C. Eckert, F. Fitzpatrick, M. Hell, T. Norèn, J. O'Driscoll, J. Coia, P. Gastmeier, L. von Müller, M.H. Wilcox, A.F. Widmer, F. Allerberger, O.A. Cornely, M. Delmée, B. Olesen, Johan van Broeck
Journal: Clinical Microbiology and Infection (2018)
RAS-mediated oncogenic signaling pathways in human malignancies
Authors: Abdul Q. Khan, Shilpa Kuttikrishnan, Kodappully S. Siveen, Kirti S. Prabhu, Muralitharan Shanmugakonar, Hamda A. Al- Naemi, Mohammad Haris, Said Dermime, Shahab Uddin
Journal: Seminars in Cancer Biology (2018)
Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association
Authors: Sharonne N. Hayes, Esther S.H. Kim, Jacqueline Saw, David Adlam, Cynthia Arslanian-Engoren, Katherine E. Economy, Santhi K. Ganesh, Rajiv Gulati, Mark E. Lindsay, Jennifer H. Mieres, Sahar Naderi, Svati Shah, David E. Thaler, Marysia S. Tweet, Malissa J. Wood
Journal: Circulation (2018)

Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute coronary syndrome, myocardial infarction, and sudden death, particularly among young women and individuals with few conventional atherosclerotic risk factors. Patient-initiated research has spurred increased awareness of SCAD, and improved diagnostic capabilities and findings from large case series have led to changes in approaches to initial and long-term management and increasing evidence that SCAD not only is more common than previously believed but also must be evaluated and treated differently from atherosclerotic myocardial infarction. High rates of recurrent SCAD; its association with female sex, pregnancy, and physical and emotional stress triggers; and concurrent systemic arteriopathies, particularly fibromuscular dysplasia, highlight the differences in clinical characteristics of SCAD compared with atherosclerotic disease. Recent insights into the causes of, clinical course of, treatment options for, outcomes of, and associated conditions of SCAD and the many persistent knowledge gaps are presented.