Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
Authors: Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepúlveda, Taane G Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret Mackinnon, Kathryn Maitland, Dominic P Kwiatkowski, Kirk A Rockett, Thomas N Williams, Amadou Abathina, Ismaela Abubakar, Eric Achidi, Tsiri Agbenyega, Mohammed Aiyegbo, Alex Akoto, Angela Allen, Stephen Allen, Lucas Amenga-Etego, Folakemi Amodu, Olukemi Amodu, Judith Anchang-Kimbi, Nana Ansah, Patrick Ansah, Daniel Ansong, Sampson Antwi, Thomas Anyorigiya, Tobias Apinjoh, Emmanuel Asafo-Agyei, Victor Asoala, Frank Atuguba, Sarah Auburn, Abdou Bah, Kariatou Bamba, Germana Bancone, Gavin Band, David Barnwell, Abdoulaye Barry, Evasius Bauni, Richard Besingi, Kalifa Bojang, Edith Bougouma, Susan Bull, George Busby, Abdoulie Camara, Landing Camara, Susana Campino, Richard Carter, Dan Carucci, Climent Casals-Pascual, Ndey Ceesay, Pa Ceesay, Tran Chau, Ly Chuong, Taane Clark, Geraldine Clarke, Ramou Cole-Ceesay, David Conway, Katharine Cook, Olivia Cook, Victoria Cornelius, Patrick Corran, Simon Correa, Sharon Cox, Rachel Craik, Bakary Danso, Timothy Davis, Nicholas Day, Panos Deloukas, Awa Dembele, Jantina deVries, Rajika Dewasurendra, Mahamadou Diakite, Elizabeth Diarra, Yaya Dibba, Andrea Diss, Abdoulaye Djimdé, Amagana Dolo, Ogobara Doumbo, Alan Doyle, Chris Drakeley, Eleanor Drury, Patrick Duffy, Sarah Dunstan, Augustine Ebonyi, Ahmed Elhassan, Ibrahim Elhassan, Abier Elzein, Anthony Enimil, Pamela Esangbedo, Jennifer Evans, Julie Evans, Jeremy Farrar, Deepika Fernando, Kathryn Fitzpatrick, Janet Fullah, Jacob Garcia, Anita Ghansah, Michael Gottleib, Angie Green, Lee Hart, Meike Hennsman, Tran Hien, Nguyen Hieu, Eliza Hilton, Abraham Hodgson, Rolf Horstmann, Christina Hubbart, Catherine Hughes, Ayman Hussein, Robert Hutton, Muntaser Ibrahim, Deus Ishengoma, Jula Jaiteh, Mariatou Jallow, Muminatou Jallow, Kebba Jammeh, Momodou Jasseh, Anna Jeffreys, Amie Jobarteh, Kimberly Johnson, Sarah Joseph, Dushyanth Jyothi, David Kachala, Dorcas Kamuya, Haddy Kanyi, Harin Karunajeewa, Nadira Karunaweera, Momodou Keita, Angeliki Kerasidou, Aja Khan, Katja Kivinen, Gilbert Kokwaro, Amadou Konate, Salimata Konate, Kwadwo Koram, Dominic Kwiatkowski, Moses Laman, Si Le, Ellen Leffler, Martha Lemnge, Enmoore Lin, Alioune Ly, Alexander Macharia, Bronwyn MacInnis, Nguyen Mai, Julie Makani, Cinzia Malangone, Valentina Mangano, Alphaxard Manjurano, Lamin Manneh, Laurens Manning, Magnus Manske, Kevin Marsh, Vicki Marsh, Gareth Maslen, Caroline Maxwell, Eric Mbunwe, Marilyn McCreight, Daniel Mead, Alieu Mendy, Anthony Mendy, Nathan Mensah, Pascal Michon, Alistair Miles, Olivo Miotto, David Modiano, Hiba Mohamed, Sile Molloy, Malcolm Molyneux, Sassy Molyneux, Mike Moore, Catherine Moyes, Frank Mtei, George Mtove, Ivo Mueller, Regina Mugri, Annie Munthali, Theonest Mutabingwa, Behzad Nadjm, Andre Ndi, Carolyne Ndila, Charles Newton, Amadou Niangaly, Haddy Njie, Jalimory Njie, Madi Njie, Malick Njie, Sophie Njie, Labes Njiragoma, Francis Nkrumah, Neema Ntunthama, Aceme Nyika, Vysaul Nyirongo, John O'Brien, Herbert Obu, Abraham Oduro, Alex Ofori, Subulade Olaniyan, Rasaq Olaosebikan, Tom Oluoch, Olayemi Omotade, Olajumoke Oni, Emmanuel Onykwelu, Daniel Opi, Adebola Orimadegun, Sean O'Riordan, Issa Ouedraogo, Samuel Oyola, Michael Parker, Richard Pearson, Paul Pensulo, Norbert Peshu, Ajib Phiri, Nguyen Phu, Margaret Pinder, Matti Pirinen, Chris Plowe, Claire Potter, Belco Poudiougou, Odile Puijalon, Nguyen Quyen, Ioannis Ragoussis, Jiannis Ragoussis, Oba Rasheed, John Reeder, Hugh Reyburn, Eleanor Riley, Paul Risley, Kirk Rockett, Joanne Rodford, Jane Rogers, William Rogers, Kate Rowlands, Valentín Ruano-Rubio, Kumba Sabally-Ceesay, Abubacar Sadiq, Momodou Saidy-Khan, Horeja Saine, Anavaj Sakuntabhai, Abdourahmane Sall, David Sambian, Idrissa Sambou, Miguel SanJoaquin, Nuno Sepúlveda, Shivang Shah, Jennifer Shelton, Peter Siba, Nilupa Silva, Cameron Simmons, Jaques Simpore, Pratap Singhasivanon, Dinh Sinh, Sodiomon Sirima, Giorgio Sirugo, Fatoumatta Sisay-Joof, Sibiry Sissoko, Kerrin Small, Elilan Somaskantharajah, Chris Spencer, Jim Stalker, Marryat Stevens, Prapat Suriyaphol, Justice Sylverken, Bintou Taal, Adama Tall, Terrie Taylor, Yik Teo, Cao Thai, Mahamadou Thera, Vincent Titanji, Ousmane Toure, Marita Troye-Blomberg, Stanley Usen, Sophie Uyoga, Aaron Vanderwal, Hannah Wangai, Renee Watson, Thomas Williams, Michael Wilson, Rebecca Wrigley, Clarisse Yafi, Lawrence Yamoah
Journal: The Lancet Haematology (2018)

Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.