tbuckley/cabot-search huggingface dataset:
Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa
Authors: J.R. Ingram, S. Jenkins-Jones, D.W. Knipe, C.L.I. Morgan, R. Cannings-John, V. Piguet
Journal: British Journal of Dermatology (2017)

Epidemiology data regarding hidradenitis suppurativa (HS) are conflicting and prevalence estimates vary 80-fold, from 0·05% in a population-based study to 4%.To assess the hypothesis that previous population-based studies underestimated true HS prevalence by missing undiagnosed cases.We performed a population-based observational and case-control study using the U.K. Clinical Practice Research Datalink (CPRD) linked to hospital episode statistics data. Physician-diagnosed cases in the CPRD were identified from specific Read codes. Algorithms identified unrecognized 'proxy' cases, with at least five Read code records for boils in flexural skin sites. Validation of proxy cases was undertaken with general practitioner (GP) questionnaires to confirm criteria-diagnosed cases. A case-control study assessed disease associations.On 30 June 2013, 23 353 physician-diagnosed HS cases were documented in 4 364 308 research-standard records. In total, 68 890 proxy cases were identified, reduced to 10 146 criteria-diagnosed cases after validation, extrapolated from 107 completed questionnaires (61% return rate). Overall point prevalence was 0·77% [95% confidence interval (CI) 0·76-0·78%]. An additional 18 417 cases had a history of one to four flexural skin boils. In physician-diagnosed cases, odds ratios (ORs) for current smoker and obesity (body mass index > 30 kg m-2 ) were 3·61 (95% CI 3·44-3·79) and 3·29 (95% CI 3·14-3·45). HS was associated with type 2 diabetes, Crohn disease, hyperlipidaemia, acne and depression, and not associated with ulcerative colitis or polycystic ovary syndrome.Contrary to results of previous population-based studies, HS is relatively common, with a U.K. prevalence of 0·77%, one-third being unrecognized, criteria-diagnosed cases using the most stringent disease definition. If individuals with probable cases are included, HS prevalence rises to 1·19%.
Up-front high-dose chemotherapy followed by autologous stem cell transplantation for high-risk aggressive lymphoma
Authors: Yuka Tanaka, Takayuki Tabayashi, Yasuyuki Takahashi, Yuta Kimura, Tatsuki Tomikawa, Tomoe Anan, Morihiko Sagawa, Reiko Watanabe, Michihide Tokuhira, Masahiro Kizaki
Journal: Annals of Oncology (2017)
Sorveglianza della tubercolosi in Irlanda
Authors: A Smith, D Igoe, D O’Flanagan, T Holohan
Journal: Eurosurveillance (2000)

I primi dati disaggregati sulla tubercolosi in Irlanda sono stati raccolti nel 1998. Sono stati notificati un totale di 424 casi (tasso 11,7/100.000 abitanti), dei quali 241 avevano coltura positiva e 122 erano casi con striscio polmonare positivo. Solo 35 casi erano nati all’estero, e non e stato identificato nessun caso multiresistente.
Le ‘Statens Serum Institute’ danois célèbre son centenaire
Authors: M. S. Vilayleck
Journal: Eurosurveillance (2002)

Le Statens Serum Institute (SSI), au Danemark, a celebre son centenaire le 9 septembre 2002. Des conferences sur les maladies emergentes et re-emergentes, les progres dans le developpement des vaccins, et le lancement d’un nouveau site Internet (www.ssi.dk) ont ete organisees.
Metodi di sorveglianza virologica sentinella dell'influenza in Europa - un'indagine in 18 paesi
Authors: T J Meerhoff, A Meijer, W J Paget
Journal: Eurosurveillance (2004)

Il sistema EISS (European Influenza Surveillance Scheme) si basa su un modello di sorveglianza clinica e virologica integrate. Per stabilire la confrontabilita dei dati virologici, e stato inviato ai partecipanti nel giugno 2002 un questionario che chiedeva informazioni sulla raccolta dei campioni, sulla diagnosi di laboratorio di influenza e sui test per altre infezioni respiratorie. I risultati hanno mostrato differenze ma anche uniformita nei metodi di raccolta dei dati virologici. Sono state riportate similarita per le procedure di raccolta dei campioni; il tipo di tampone e le condizioni di trasporto erano confrontabili. I metodi diagnostici erano diversi; le differenze si sono viste nei metodi di tipizzazione, con la PCR usata piu spesso nei paesi occidentali. I risultati saranno utili per l'interpretazione dei dati virologici raccolti dai medici sentinella e per la creazione di un network europeo di laboratori di riferimento per l'influenza. Importanti obiettivi del network includono la armonizzazione dei metodi virologici e la applicazione di misure di controllo di qualita per i laboratori nazionali di riferimento.
Rational design of Polymeric Hybrid Micelles to Overcome Lymphatic and Intracellular Delivery Barriers in Cancer Immunotherapy
Authors: Hanmei Li, Yanping Li, Xue Wang, Yingying Hou, Xiaoyu Hong, Tao Gong, Zhirong Zhang, Xun Sun
Journal: Theranostics (2017)

Poor distribution of antigen/adjuvant to target sites and inadequate induction of T cell responses remain major challenges in cancer immunotherapy because of the lack of appropriate delivery systems. Nanocarrier-based antigen delivery systems have emerged as an innovative strategy to improve vaccine efficacy. Here we present polymeric hybrid micelles (PHMs) as a simple and potent antigen/adjuvant co-delivery system with highly tunable properties. PHMs consist of two amphiphilic diblock copolymers, polycaprolactone-polyethylenimine (PCL-PEI) and polycaprolactone-polyethyleneglycol (PCL-PEG). PHMs with different proportions of cationic PCL-PEI were prepared and loaded with tyrosinase-related protein 2 (Trp2) peptide and adjuvant CpG oligodeoxynucleotide to generate the Trp2/PHM/CpG co-delivery system. Lymphatic and intracellular antigen delivery as a function of PCL-PEI proportion was evaluated in vitro and in vivo. PHMs containing 10% (w/w) PCL-PEI (Trp2/PHM10/CpG) showed the optimal balance of good distribution to lymph nodes, strong immunization effect after subcutaneous administration, and low toxicity to dendritic cells. In a mouse model of B16F10 melanoma, Trp2/PHM10/CpG showed significantly higher antigen-specific cytotoxic T lymphocyte activity and greater anticancer efficacy than Trp2/PHM0/CpG without PCL-PEI or a mixture of free Trp2 and CpG. These results provide new insights into how cationic segments affect the efficiency of antigen delivery by cationic nanocarriers. They also suggest that PHMs can serve as a structurally simple and highly tunable platform for co-delivery of antigen and adjuvant in cancer immunotherapy.
TCT-848 Percutaneous coronary intervention with Absorb bioresorbable vascular scaffold: major adverse cardiac events, restenosis and device thrombosis after 2-years follow-up. Single center experience in an all-comers population
Authors: Antonio De Miguel Castro, Etelberto Hernandez, Victor Jimenez Diaz, Alberto Ortiz Saez, Guillermo Bastos Fernández, Saleta Fernández Barbeira, Ivan Gomez-Blazquez, Jose Baz, Andres Iñiguez
Journal: Journal of the American College of Cardiology (2017)
TCT-467 Association of Chronic Total Occlusion with In-Hospital Outcomes after Percutaneous Coronary Intervention for Acute Myocardial Infarction: Insights from the National Inpatient Sample Database
Authors: Mohamed Omer, David Safley, Kevin Kennedy, Ahmed Mahmoud, Islam Elgendy, Mohammed Qintar, Jonathan Enriquez, J. Aaron Grantham
Journal: Journal of the American College of Cardiology (2017)
Surto de toxinfecção alimentar por Salmonella enteritidis num hospital psiquiátrico em Dublin, Irlanda
Authors: T Grein, D O’Flanagan, T McCarthy, T Prendergast
Journal: Eurosurveillance (1997)

A 29 de Agosto de 1996, a direccao de saude do leste da Irlanda (Eastern Health Board -EHB) foi informada dum surto de gastroenterites num hospital psiquiatrico em Dublin. Desde 27 de Agosto de 1996, tinham adoecido 50 pessoas de entre os 240 membros do pessoal e 183 doentes, e novos casos continuavam a aparecer. O EHB lancou imediatamente um inquerito para avaliar a extensao do surto, identificar o modo e o veiculo de transmissao e aplicar as medidas de controlo apropriadas.
TCT-213 Physiological characterization of the non-culprit artery in patients with acute myocardial infarction
Authors: Felipe Diez-Delhoyo, Enrique Gutiérrez, Ricardo Sanz-Ruiz, Fernando Sarnago Cebada, Allan Rivera, Hugo Gonzalez Saldivar, Jaime Elizaga, Francisco Fernandez-Aviles
Journal: Journal of the American College of Cardiology (2017)
Different Standards When Assessing the Evidence for Psychodynamic Therapy? Response to Cristea et al.
Authors: Christiane Steinert, Thomas Munder, Sven Rabung, Jürgen Hoyer, Falk Leichsenring
Journal: American Journal of Psychiatry (2017)

Cristea and colleagues raise some concerns about our meta-analysis on psychodynamic therapy compared with treatments established in efficacy (1).
Abstract 16690: Multi-modality Imaging With 18-fluoro-d-glucose (fdg) Pet and Cardiac Magnetic Resonance (cmr) Imaging to Identify Metabolical Remodeling in Patients With Ischemic Ventricular Tachycardia Substrate
Authors: Kiddy L Ume, Hasan Imanli, Jean Jeudy, Mark Smith, Wengen Chen, Rama Vunnam, John Duell, Shaun Bhatty, Yousra Ghzally, Anastosis Saliaris, Vincent See, Stephen Shorofsky, Vasken Dilsizian, Timm M Dickfeld
Journal: Circulation (2016)

Introduction:  Both late gadolinium enhanced (LGE) CMR scar as well as FDG-positron emission tomography (PET) have been independently validated for the assessment of ischemic ventricular scar. We hypothesized that by combining both imaging technologies (i.e. extracellular fibrosis by CMR and metabolism of surviving myocardial cells), it is possible to detect abnormal remodeling processes within the ischemic scar characterized by preferential for cytosolic glycolysis, which provide a pathophysiological basis for possible proarrhythmic adaptions within the cellular ischemic VT substrate.   Methods:  Pre-ablation LGE-CMR and FDG-PET images of the left ventricle in 9 patients undergoing ablation for drug-refractory, ischemic ventricular tachycardia were reconstructed using SEGMENT (Medviso) and PCARD (pMOD) software. Using high resolution 757-segment polar plots, the presence and transmural extent of LGE CMR defined scar as well as the FDG uptake of surviving myocardial cells (normalized to perfusion) in each segment were determined. Additionally, in each segment, relative metabolic activity per mm of surviving, non-LGE myocardium was calculated and analyzed in corresponding 2D polar plots.   Results:  All patients had regions of decreased FDG uptake, located inferiorly (n=4), infero-laterally (n=3), antero-apically (n=1) and laterally (n=1). The location of decreased tracer uptake matched CMR fibrosis in all patients. Overall, CMR scar was not significantly different from PET scar (187±103 segments vs 142±85 segments, p=0.3). However, significant CMR/PET mismatch pattern (differences of >20% in segmental scar area) was seen in 3 patients, with CMR>PET in all three. Quantitative segmental analysis of those mismatching areas demonstrated a >3-fold increase in relative FDG uptake (per mm 3  of living tissue) compared to remote myocardium, suggesting significant metabolic remodeling.   Conclusions:  This is the first-in-human demonstration that multi-modality scar imaging using high resolution CMR and molecular, metabolic PET imaging has the potential to detect regional cellular remodeling and provide new pathophysiological insights into the possible proarrhythmic cellular adaptation within the ischemic scar substrate.
TCT-284 DuraGraft, a one-time intraoperative treatment against vein graft failure: A randomized multicenter trial using longitudinal MDCT angiography analysis in patients undergoing CABG
Authors: Maximilian Emmert, Pierre Voisine, Peter Skov Olson, Nicolas Noiseux, Hugues Jeanmart, Dave Veerasingam, Craig Brown, Louis Perrault
Journal: Journal of the American College of Cardiology (2017)
Identification and characterization of T reg–like cells in zebrafish
Authors: Melissa Kasheta, Corrie A. Painter, Finola E. Moore, Riadh Lobbardi, Alysia Bryll, Eli Freiman, David Stachura, Arlin B. Rogers, Yariv Houvras, David M. Langenau, Craig J. Ceol
Journal: The Journal of Experimental Medicine (2017)

Regulatory T (T reg) cells are a specialized sublineage of T lymphocytes that suppress autoreactive T cells. Functional studies of T reg cells in vitro have defined multiple suppression mechanisms, and studies of T reg-deficient humans and mice have made clear the important role that these cells play in preventing autoimmunity. However, many questions remain about how T reg cells act in vivo. Specifically, it is not clear which suppression mechanisms are most important, where T reg cells act, and how they get there. To begin to address these issues, we sought to identify T reg cells in zebrafish, a model system that provides unparalleled advantages in live-cell imaging and high-throughput genetic analyses. Using a FOXP3 orthologue as a marker, we identified CD4-enriched, mature T lymphocytes with properties of T reg cells. Zebrafish mutant for foxp3a displayed excess T lymphocytes, splenomegaly, and a profound inflammatory phenotype that was suppressed by genetic ablation of lymphocytes. This study identifies T reg-like cells in zebrafish, providing both a model to study the normal functions of these cells in vivo and mutants to explore the consequences of their loss.
CROSSOVER FROM RADIAL TO IPSILATERAL ULNAR ARTERY: A SAFE AND FEASIBLE ALTERNATIVE IN COMPLEX RADIAL ARTERY ANATOMY
Authors: Nagaraja Moorthy, Rajiv Ananthakrishna, P.V. Dattatreya, Rangaraj Ramalingam, C.N. Manjunath
Journal: Journal of the American College of Cardiology (2017)
DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis
Authors: Fei Ye, Eunchai Kang, Chuan Yu, Xuyu Qian, Fadi Jacob, Cong Yu, Mao Mao, Randy Y.C. Poon, Jieun Kim, Hongjun Song, Guo-li Ming, Mingjie Zhang
Journal: Neuron (2017)
TCT-729 Four-Year Clinical Outcomes in ‘Real-World’ Patients Treated With a Thin-Strut, Platinum-Chromium, Everolimus-Eluting Stent: Results from the PROMUS Element Plus US Post-Approval Study (PE-Plus PAS)
Authors: David Kandzari, Peter Ver Lee, Anil Chhabra, Jerrold Grodin, Maria Bartlett, Richard Zelman, Walt Marquardt, Thomas Christen, Ian Meredith
Journal: Journal of the American College of Cardiology (2017)
Analysis of ITGB2 rare germ line variants in chronic lymphocytic leukemia
Authors: Grace Tiao, M. Reina Improgo, Eugen Tausch, Stacey M. Fernandes, Jasmin Bahlo, Sandra Robrecht, Kirsten Fischer, Michael Hallek, Stephan Stilgenbauer, Adam Kiezun, Gad Getz, Jennifer R. Brown
Journal: Blood (2017)
Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression
Authors: Peipei Guo, Michael G. Poulos, Brisa Palikuqi, Chaitanya R. Badwe, Raphael Lis, Balvir Kunar, Bi-Sen Ding, Sina Y. Rabbany, Koji Shido, Jason M. Butler, Shahin Rafii
Journal: Journal of Clinical Investigation (2017)

Angiocrine factors, such as Notch ligands, supplied by the specialized endothelial cells (ECs) within the bone marrow and splenic vascular niche play an essential role in modulating the physiology of adult hematopoietic stem and progenitor cells (HSPCs). However, the relative contribution of various Notch ligands, specifically jagged-2, to the homeostasis of HSPCs is unknown. Here, we show that under steady state, jagged-2 is differentially expressed in tissue-specific vascular beds, but its expression is induced in hematopoietic vascular niches after myelosuppressive injury. We used mice with EC-specific deletion of the gene encoding jagged-2 (Jag2) to demonstrate that while EC-derived jagged-2 was dispensable for maintaining the capacity of HSPCs to repopulate under steady-state conditions, by activating Notch2 it did contribute to the recovery of HSPCs in response to myelosuppressive conditions. Engraftment and/or expansion of HSPCs was dependent on the expression of endothelial-derived jagged-2 following myeloablation. Additionally, jagged-2 expressed in bone marrow ECs regulated HSPC cell cycle and quiescence during regeneration. Endothelial-deployed jagged-2 triggered Notch2/Hey1, while tempering Notch2/Hes1 signaling in HSPCs. Collectively, these data demonstrate that EC-derived jagged-2 activates Notch2 signaling in HSPCs to promote hematopoietic recovery and has potential as a therapeutic target to accelerate balanced hematopoietic reconstitution after myelosuppression.
Safety, immunogenicity and efficacy after switching from reference infliximab to biosimilar SB2 compared with continuing reference infliximab and SB2 in patients with rheumatoid arthritis: results of a randomised, double-blind, phase III transition study
Authors: Josef S Smolen, Jung-Yoon Choe, Nenad Prodanovic, Jaroslaw Niebrzydowski, Ivan Staykov, Eva Dokoupilova, Asta Baranauskaite, Roman Yatsyshyn, Mevludin Mekic, Wieslawa Porawska, Hana Ciferska, Krystyna Jedrychowicz-Rosiak, Agnieszka Zielinska, Younju Lee, Young Hee Rho
Journal: Annals of the Rheumatic Diseases (2017)

Efficacy, safety and immunogenicity results from the phase III study of SB2, a biosimilar of reference infliximab (INF), were previously reported through 54 weeks. This transition period compared results in patients with rheumatoid arthritis (RA) who switched from INF to SB2 with those in patients who maintained treatment with INF or SB2.Patients with moderate to severe RA despite methotrexate treatment were randomised (1:1) to receive SB2 or INF at weeks 0, 2 and 6 and every 8 weeks thereafter until week 46. At week 54, patients previously receiving INF were rerandomised (1:1) to switch to SB2 (INF/SB2 (n=94)) or to continue on INF (INF/INF (n=101)) up to week 70. Patients previously receiving SB2 continued on SB2 (SB2/SB2 (n=201)) up to week 70. Efficacy, safety and immunogenicity were assessed up to week 78.Efficacy was sustained and comparable across treatment groups. American College of Rheumatology (ACR) 20 responses between weeks 54 and 78 ranged from 63.5% to 72.3% with INF/SB2, 66.3%%-69.4% with INF/INF and 65.6%-68.3% with SB2/SB2. Treatment-emergent adverse events during this time occurred in 36.2%, 35.6% and 40.3%, respectively, and infusion-related reactions in 3.2%, 2.0% and 3.5%. Among patients who were negative for antidrug antibodies (ADA) up to week 54, newly developed ADAs were reported in 14.6%, 14.9% and 14.1% of the INF/SB2, INF/INF and SB2/SB2 groups, respectively.The efficacy, safety and immunogenicity profiles remained comparable among the INF/SB2, INF/INF and SB2/SB2 groups up to week 78, with no treatment-emergent issues or clinically relevant immunogenicity after switching from INF to SB2.NCT01936181; EudraCT number: 2012-005733-37.
TCT-221 Treatment Recommendations Based on SYNTAX Score II and Observed 3-year Mortality in the EXCEL Trial
Authors: Patrick Serruys, Carlos Collet, Yoshinobu Onuma, Marie-Angele Morel, Ovidiu Dressler, Yiran Zhang, Martin Leon, Marie-Claude Morice, Philippe Genereux, David Kandzari, A. Pieter Kappetein, Joseph Sabik, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression
Authors: Xiaosa Li, Weiyu Chen, Ping Li, Jinzhi Wei, Yang Cheng, Pei Liu, Qing Yan, Xingyan Xu, Yuhong Cui, Zhengtian Gu, Tommaso Simoncini, Xiaodong Fu
Journal: Theranostics (2017)

Rationale: Postmenopausal atherosclerosis (AS) has for decades been attributed to estrogen deficiency. Although the follicular stimulating hormone (FSH) levels rise sharply in parallel, the direct effect of FSH on AS has never been investigated. In this study, we explored the possible role of FSH in the development of AS. Methods: This was a prospective cohort study of 48 healthy premenopausal and 15 postmenopausal women. ApoE knockout mice were used as atherosclerosis model and human umbilical vascular endothelial cells (HUVECs) were cultured as cell model. Serum hormones and vascular cell adhesion molecule-1 (VCAM-1) levels were measured. Real-time PCR, histology for atherosclerotic lesions, immunofluorescence, luciferase assay, transfection experiments, flow chamber adhesion assay and western blot were performed. Results: In ApoE knockout mice, administration of FSH increased the atherosclerotic lesions and serum VCAM-1 concentration. Importantly, in blood samples of postmenopausal women, we detected significantly higher levels of FSH and VCAM-1 compared with those from premenopausal women, and there was a positive correlation between these two molecules. In cultured HUVECs, FSH receptor (FSHR) mRNA and protein expression were detected and FSH enhanced VCAM-1 expression. This effect was mediated by the activation of nuclear factor κB (NF-κB), which was sequentially enhanced by the activation of PI3K/Akt/mTOR cascade. FSH first enhanced GαS activity resulting in elevated cAMP level and PKA activity, which relayed the signals from FSHR to the PI3K/Akt/mTOR cascade. Furthermore, FSHR was detected in endothelial caveolae fraction and interacted with caveolin-1 and GαS. The disruption of caveolae or the silencing of caveolin-1 blocked FSH effects on signaling activation and VCAM-1 expression, suggesting the existence of a functional signaling module in membrane caveolae. Finally, FSH increased human monocyte adhesion to HUVECs which was reversed by the VCAM-1 neutralizing antibody. Conclusion: FSHR was located in the membrane caveolae of HUVECs and FSH promoted VCAM-1 expression via FSHR/GαS /cAMP/PKA and PI3K/Akt/mTOR/NF-κB pathway. This may contribute to the deleterious role of FSH in the development of AS in postmenopausal women.
Prediabetes Prevalence in China
Authors: Nanlin Fu, Yan Jiang, Wenjie Sun
Journal: JAMA (2017)

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