tbuckley/cabot-search huggingface dataset:
Prognostic Value of Follow-Up Hemodynamic Variables After Initial Management in Pulmonary Arterial Hypertension
Authors: Jason Weatherald, Athénaïs Boucly, Denis Chemla, Laurent Savale, Mingkai Peng, Mitja Jevnikar, Xavier Jaïs, Yu Taniguchi, Caroline O’Connell, Florence Parent, Caroline Sattler, Philippe Hervé, Gérald Simonneau, David Montani, Marc Humbert, Yochai Adir, Olivier Sitbon
Journal: Circulation (2017)

Background: Hemodynamic variables such as cardiac index and right atrial pressure have consistently been associated with survival in pulmonary arterial hypertension (PAH) at the time of diagnosis. Recent studies have suggested that pulmonary arterial compliance may also predict prognosis in PAH. The prognostic importance of hemodynamic values achieved after treatment initiation is less well established. Methods: Our objective was to evaluate the prognostic importance of clinical and hemodynamic variables during follow-up, including pulmonary arterial compliance, after initial management in PAH. We evaluated incident patients with idiopathic, drug- and toxin-induced, or heritable PAH enrolled in the French pulmonary hypertension registry between 2006 and 2016 who had a follow-up right-sided heart catheterization (RHC). The primary outcome was death or lung transplantation. We used stepwise Cox regression and the Kaplan-Meier method to assess variables obtained at baseline and at first follow-up RHC. Results: Of 981 patients, a primary outcome occurred in 331 patients (33.7%) over a median follow-up duration of 2.8 years (interquartile range, 1.1–4.6 years). In a multivariable model considering only baseline variables, no hemodynamic variables independently predicted prognosis. Median time to first follow-up RHC was 4.6 months (interquartile range, 3.7–7.8 months). At first follow-up RHC (n=763), New York Heart Association functional class, 6-minute walk distance, stroke volume index (SVI), and right atrial pressure were independently associated with death or lung transplantation, adjusted for age, sex, and type of PAH. Pulmonary arterial compliance did not independently predict outcomes at baseline or during follow-up. The adjusted hazard ratio for SVI was 1.28 (95% confidence interval, 1.11–1.49; P &lt;0.01) per 10-mL/m 2 decrease and for right atrial pressure was 1.05 (95% confidence interval, 1.02–1.09; P &lt;0.01) per 1–mm Hg increase. Among patients who had 2 (n=355) or 3 (n=193) low-risk prognostic features at follow-up, including a cardiac index ≥2.5 L·min −1 ·m −2 , 6-minute walk distance &gt;440 m, and New York Heart Association class I or II functional class, lower SVI was still associated with higher rates of death or lung transplantation ( P &lt;0.01). Conclusions: SVI and right atrial pressure were the hemodynamic variables that were independently associated with death or lung transplantation at first follow-up RHC after initial PAH treatment. These findings suggest that the SVI could be a more appropriate treatment target than cardiac index in PAH.
The Concertina Case of Ventricular Preexcitation
Authors: Anoop Muniyappa, Arvind Nishtala, Nora Goldschlager
Journal: JAMA Internal Medicine (2017)

A healthy man in his early 40s presented to the emergency department after a second syncopal episode in 2 weeks. Both episodes occurred without prodromal symptoms, tonic-clonic movements, tongue biting, or incontinence, and the patient felt normal afterward.
Brote de Salmonella Enteritidis fagotipo 13a: estudio de casos y controles en Hertsmere, Reino Unido
Authors: O Morgan, L Milne, S Kumar, D Murray, W Man, M Georgiou, N Q Verlander, E de Pinna, M McEvoy
Journal: Eurosurveillance (2007)

En Junio de 2006 se notificaron a la Autoridad Municipal de Hertsmere varios casos de enfermedad gastrointestinal entre los participantes en un acto benefico infantil. Las pruebas iniciales de laboratorio identificaron la Salmonella Enteritidis PT13a como posible causa del brote.
Paludismo en la Región Europea de la OMS (1971–1999)
Authors: G Sabatinelli, M Ejov, P Joergensen
Journal: Eurosurveillance (2001)

Entre 1996 y 1999, el numero de casos autoctonos de paludismo declarados en la region Europea de la OMS cayo de 90.506 a 37.170. Sin embargo, los casos importados han aumentado ocho veces desde los anos setenta: en 1972 se declararon 1.500 casos; en 1999, 13.000. Francia, Alemania, Italia y el Reino Unido son los paises europeos occidentales con el mayor numero notificado de casos importados.
TCT-326 Rheumatoid Arthritis in Patients with Acute Coronary Syndrome: Readmission rates, costs, and outcomes from the Nationwide Readmission Database
Authors: Young-Ji Seo, Aditya Mantha, Katherine Bailey, Esteban Aguayo, Vishal Dobaria, Yen-Yi Juo, Peyman Benharash, Ramin Ebrahimi
Journal: Journal of the American College of Cardiology (2017)
Survival data of postoperative adjuvant chemotherapy of cisplatin plus vinorelbine for completely resected NSCLC
Authors: Hirotsugu Kenmotsu, Yasuhisa Ohde, Kazushige Wakuda, Kazuhisa Nakashima, Shota Omori, Akira Ono, Tateaki Naito, Haruyasu Murakami, Masahiro Endo, Toshiaki Takahashi
Journal: Annals of Oncology (2017)
TCT-856 Comparative initial cost and length of stay for transcatheter and surgical Pulmonic valve replacement: insights from a National Database
Authors: Arka Chatterjee, Nirmanmoh Bhatia, Marc Cribbs, Manyoo Agarwal, Divyanshu Mohananey, Sahil Agrawal, Amrita Mukherjee, Mark Law
Journal: Journal of the American College of Cardiology (2017)
Surto de parodidite associado a uma fraca eficácia da vacinação - Porto, Portugal, 1996
Authors: G Gonçalves, A de Araújo, M. L. Monteiro Cardoso
Journal: Eurosurveillance (1998)

A vacinacao contra a parodidite em Portugal teve inicio em 1987, com a introducao da vacina combinada do sarampo, parodidite e rubeola (VASPR) no Programa Nacional de Vacinacao (PNV) para ambos os sexos, aos 15 meses de idade. Em Novembro de 1990, foi adicionada ao PNV uma segunda dose da VASPR, dos 11 aos 13 anos de idade. Em Outubro de 1992, efeitos secundarios atribuidos a estirpe da parodidite (Urabe Am9) levaram o Ministerio da Saude Portugues a substituir a VASPR utilizada em todo o pais por uma VASPR que continha a estirpe Rubini como vacina da parodidite. O primeiro fornecimento da nova vacina chegou ao Porto e foi distribuido pelos centros de saude distritais em Outubro de 1992.
Poly(N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications
Authors: Kenichi Nagase, Masayuki Yamato, Hideko Kanazawa, Teruo Okano
Journal: Biomaterials (2017)

Thermoresponsive surfaces, prepared by grafting of poly(N-isopropylacrylamide) (PIPAAm) or its copolymers, have been investigated for biomedical applications. Thermoresponsive cell culture dishes that show controlled cell adhesion and detachment following external temperature changes, represent a promising application of thermoresponsive surfaces. These dishes can be used to fabricate cell sheets, which are currently used as effective therapies for patients. Thermoresponsive microcarriers for large-scale cell cultivation have also been developed by taking advantage of the thermally modulated cell adhesion and detachment properties of thermoresponsive surfaces. Furthermore, thermoresponsive bioseparation systems using thermoresponsive surfaces for separating and purifying pharmaceutical proteins and therapeutic cells have been developed, with the separation systems able to maintain their activity and biological potency throughout the procedure. These applications of thermoresponsive surfaces have been improved with progress in preparation techniques of thermoresponsive surfaces, such as polymerization methods, and surface modification techniques. In the present review, the various types of PIPAAm-based thermoresponsive surfaces are summarized by describing their preparation methods, properties, and successful biomedical applications.
TCT-413 Clinical Relevance of Adverse Plaque and Hemodynamic Characteristics in Non-obstructive Lesions in the Prediction of Risk for Acute Coronary Syndrome
Authors: Jiesuck Park, Joo Myung Lee, Doyeon Hwang, Tae-Min Rhee, Jonghanne Park, Ki Hong Choi, Bon-Kwon Koo, Gilwoo Choi, Charles Taylor, Jung-Kyu Han, Han-Mo Yang, Kyung Woo (KW) Park, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2017)
TCT-207 Endovascular renal sympathetic denervation to improve heart failure with reduced ejection fraction, preliminary results IMPROVE-HF-I study
Authors: Lida Feyz, Alina Constantinescu, Bas van Dalen, Maureen Henneman, Isabella Kardys, Nicolas Van Mieghem, Olivier Manintveld, Joost Daemen
Journal: Journal of the American College of Cardiology (2017)
A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes
Authors: Bénédicte Machiels, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil, Catherine Sabatel, Daniel Desmecht, François Lallemand, Philippe Martinive, Hamida Hammad, Martin Guilliams, Benjamin Dewals, Alain Vanderplasschen, Bart N Lambrecht, Fabrice Bureau, Laurent Gillet
Journal: Nature Immunology (2017)
Un-diagnosing persistent adult asthma
Authors: Brian J. Lipworth, Sunny Jabbal
Journal: European Respiratory Journal (2017)

The diagnosis of asthma is usually based on typical symptoms, family history, audible wheeze, peak flow, spirometry, possibly in conjunction with atopy and blood eosinophilia, as well as response to treatment. In cases for which the diagnosis is less clear-cut, other tests may be required, including impulse oscillometry (IOS), exhaled nitric oxide fraction (FeNO) and bronchial challenge testing (figure 1). A pragmatic process should be considered in patients with a questionable asthma diagnosis <http://ow.ly/VRNr30fwzgs>
OA01.05 Radiation Dose and Fractionation for Limited-Stage Small Cell Lung Cancer: A Survey of US Radiation Oncologists on Practices
Authors: M.J. Farrell, J. Yahya, C. Degnin, Y. Chen, J.M. Holland, M.A. Henderson, J.J. Jaboin, M.M. Harkenrider, C.R. Thomas, T. Mitin
Journal: Journal of Thoracic Oncology (2017)

Thoracic radiotherapy (TRT) with concurrent chemotherapy is a standard treatment for patients with limited-stage small cell lung cancer (LS-SCLC). However, the optimal dose and fractionation schedule remain unclear. National Comprehensive Cancer Network (NCCN) guidelines recommend either 45 Gy delivered twice daily (BID)—based on a randomized trial showing superiority of 45 Gy BID over 45 Gy once a day (QD)—or 60-70 Gy QD. The recent EORTC 08072 (CONVERT) trial revealed no significant survival difference between 45 Gy BID and 66 Gy QD, and the ongoing CALGB 30610 trial is comparing similar regimens. Current US practice patterns for patients with LS-SCLC are unknown. We hypothesized that wide variability exists in dose-fractionation utilization among clinicians. We surveyed practicing US radiation oncologists (ROs) via an IRB-approved online questionnaire. Questions covered background characteristics, self-rated knowledge of key trials, and treatment recommendations for LS-SCLC. We received 309 responses from practicing ROs. 60% of respondents preferred to administer TRT QD, and 76% acknowledged QD TRT to be more common in their practice. There was 100% concordance between preferring QD and administering QD treatment in practice, whereas 40% of respondents who preferred BID treatments actually administered QD more commonly. 15% of physicians were unwilling to switch from QD to BID and 3% were unwilling to switch from BID to QD, even if requested by patients, and these physicians were more likely to have greater than 10 years of experience after residency training (p=0.05). Almost all respondents (88%) recommended a total dose of 45 Gy for BID treatment. For QD treatment, there was more division—54% opted for 60 Gy, 30% for 63-66 Gy, and 10% for 70 Gy. Respondents who prescribed doses higher than 60 Gy QD were more likely to be familiar with the CALGB 30610 and EORTC 08072 trials (p=0.01). There is great variability in how US ROs approach TRT dosing and fractionation in patients with LS-SCLC. Over three quarters of respondents administer TRT QD. The most common doses were 60 Gy for QD administration and 45 Gy for BID administration. Results of ongoing trials are eagerly anticipated to provide clarity on the optimal plan for patients with LS-SCLC. Moreover, this survey can inform development of future clinical trials that depend on participation from radiation oncologists.
Abstract 19115: Effect of the Peripheral Opioid Receptor Antagonist Methylnaltrexone on the Pharmacokinetic and Pharmacodynamic Profiles of Ticagrelor in Patients Receiving Morphine: A Prospective Randomized Placebo-Controlled Trial
Authors: Francesco Franchi, Fabiana Rollini, Yongwhi Park, Jenny Hu, Megha Kureti, Jose Rivas, Jumana Mewa, Gabriel Faz, Dmitry Yaranov, Latonya Been, Patrick Antoun, Daniel Soffer, Martin M Zenni, Theodore A Bass, Dominick J Angiolillo
Journal: Circulation (2016)

Introduction: Morphine causes delayed onset of action of ticagrelor by inhibiting gastric emptying and leading to delayed drug absorption. Methylnaltrexone (MNT) is a peripheral opioid receptor ant...
Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community
Authors: Francesc Coll, Ewan M. Harrison, Michelle S. Toleman, Sandra Reuter, Kathy E. Raven, Beth Blane, Beverley Palmer, A. Ruth M. Kappeler, Nicholas M. Brown, M. Estée Török, Julian Parkhill, Sharon J. Peacock
Journal: Science Translational Medicine (2017)

Longitudinal genomic and epidemiological surveillance of methicillin-resistant Staphylococcus aureus in the UK reveals extensive transmission in hospitals and the community.
Dual modal ultra-bright nanodots with aggregation-induced emission and gadolinium-chelation for vascular integrity and leakage detection
Authors: Guangxue Feng, Jackson Liang Yao Li, Carla Claser, Akhila Balachander, Yingrou Tan, Chi Ching Goh, Immanuel Weng Han Kwok, Laurent Rénia, Ben Zhong Tang, Lai Guan Ng, Bin Liu
Journal: Biomaterials (2017)
Cadi-05 in management of myeloma
Authors: Bakulesh Khamar, Dipankar Nandi, Banishree Saha
Journal: Cancer Research (2007)

3549  Poly-TLR agonist poly-antigenic vaccine Cadi-05 in management of murine multiple myeloma  Cadi-05 is a novel poly-TLR agonist poly-antigenic vaccine containing heat killed Mycobacterium W. It is a potent Th1 response enhancer. It does not induce Th2 response.It moulates TNF-alpha and No. It is undergoing evaluation in management of varieties of cancers in clinical (Phase I and Phase II for Malignant Melanoma,superficial bladder cancer,NSCLC, Hormone refractory prostate cancer) as well as preclinical studies*. It has been evaluated for its efficacy in murine Multiple Myeloma tumor model .Multiple Myeloma was induced in 4-6 week old Balb-C mice by subcutaneous injection of non secretor myeloma cell line Sp2/O cells (107). Solid tumors developed within 7-10 days. Efficacy of Cadi-05 administered intradermal aas well as intraperitoneal route was evaluated. Treatment group I received single intra-dermal injection of 0.1 ml of Cadi-05. Treatment group II received 0.1 mi of Cadi-05 by intra-peritoneal injection. Control group did not receive any intervention. Each group had 16 animals. All animals were evaluated for no. and size of tumors on day 14th. Analysis of results reveals that single intra-dermal injection of Cadi-05 results in significant decrease in size as well as no. of tumors compared to control group as well as group receiving intra-peritoneal cadi-05. No tumor was detected in 12 of 16(75%) animals in intra-dermal group. The no. of animals without tumor was 6 of 16(37.5%) in intra-peritoneal group.(0.05>p>0.01;Chi square) Key cellular effectors and molecules involved in this process are being elucidated. The findings indicate that single injection of Cadi-05 is effective in Sp2O model of murine multiple myeloma when administered by an intra-dermal route.  *References:  1..Poly-TLR agonist poly-antigenic vaccine Cadi-05 in advanced bladder cancer. Proc. AACR2006;47:682 abstract#2904.  2.Poly-TLR agonist polyantigenic vaccine Cadi-05 in advanced non small cell lung cancer. Proc. AACR2006;47:682 abstract#2904.  3. Role of immunotherapy as a adjuvant treatment in advance head & neck cancer, patient receiving chemo radiotherapy. J. Clinical Oncology2005;(16s Part1):190s page 2598  4. Use of Immunomodulator mycobacterium w vaccine for palliative treatment in advanced & incurable cancer patients.J. Clinical Oncology2005;(16s Part1):188s page 2592  5. Role of mycobacterium w as an adjuvant treatment of head & neck cancer - A randomized trial. J. Clinical Oncology2005;(16s Part1):521s page 5588
Botulismo por feridas em utilizadores de drogas injectadas : aumento dos casos na Inglaterra em 2004
Authors: D Akbulut, J Dennis, M Gent, K A Grant, V Hope, C Ohai, J McLauchlin, V Mithani, O Mpamugo, F Ncube, L De Souza-Thomas
Journal: Eurosurveillance (2005)

As infeccoes das feridas produzidas por Clostridium botulinum nao foram reconhecidas no Reino Unido e na Republica de Irlanda antes de 2000. C. Botulinum produz uma neurotoxina potente que pode causar paralisia e morte. Em 2000 e 2001, foram reconhecidos 10 casos, seguidos de 23 em 2002 e 40 em 2004, todos em utilisadores de heroina injectavel. Setenta casos foram detectados na Inglaterra, os outros na Escocia (12), Gales (2) e Republica de Irlanda (4). Quarenta e cinco por cento (40/88) dos casos foram confirmados em laboratorio por deteccao da neurotoxina botulinica no soro ou por isolamento de C. Botulinum a partir de feridas. Dos quarenta casos de 2004, 36 foram detectados na Inglaterra e entre os 12 confirmados por laboratorio, 10 eram devidos ao tipo A. Durante o mesmo ano, alguns casos estavam regrupados geograficamente, a maioria deles em Londres e nas areas de Yorkshire e Humberside no nordeste da Inglaterra.
Dominance as a competence domain, and the evolutionary origins of respect and contempt
Authors: Bernard Chapais
Journal: Behavioral and Brain Sciences (2017)

The hypothesis of a phylogenetic connection between protorespect in primate dominance hierarchies and respect in human prestige hierarchies lies in the principle that dominance is a domain of competence like others and, hence, that high-ranking primates have protoprestige. The idea that dominant primates manifest protocontempt to subordinates suggests that "looking down on" followers is intrinsic to leadership in humans, but that the expression of contempt varies critically in relation to the socioecological context.
TCT-468 One-year Clinical Outcomes of Successful Coronary Chronic Total Occlusion Intervention in Patients with Acute Coronary Syndrome; From the Korean, Nationwide, Multicenter CTO (K-CTO) Registry
Authors: Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, None ahmed mashaly, Won Young Jang, Woo Hyeun Kim, Eun Jin Park, Ja Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh, Yangsoo Jang
Journal: Journal of the American College of Cardiology (2017)
Source of Tumor Proteins. I. Effect of a Low-Nitrogen Diet on the Establishment and Growth of a Transplanted Tumor&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Florence R. White, Morris Belkin
Journal: JNCI Journal of the National Cancer Institute (1945)

Source of Tumor Proteins. I. Effect of a Low-Nitrogen Diet on the Establishment and Growth of a Transplanted Tumor Get access Florence R. White, Florence R. White associate biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Morris Belkin Morris Belkin Department of Pathology, Yale University School of Medicine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 5, Issue 4, February 1945, Pages 261–263, https://doi.org/10.1093/jnci/5.4.261 Published: 01 February 1945
La surveillance de la lymphogranulomatose vénérienne rectale en France, 2004-2005
Authors: M Herida, B de Barbeyrac, P Sednaoui, C Scieux, N Lemarchand, G Kreplak, M Clerc, J Timsit, V Goulet, J C Desenclos, C Semaille
Journal: Eurosurveillance (2006)

La lymphogranulomatose venerienne (LGV) est une infection sexuellement transmissible (IST) due aux souches de Chlamydia trachomatis appartenant au genotype L1, L2 ou L3. 
Une alerte portant sur une epidemie de LGV chez des hommes ayant des rapports sexuels avec d’autres hommes aux Pays-Bas a ete publiee en janvier 2004. Les premiers cas de LGV rectale en France ont ete diagnostiques en mars 2004. En avril 2004, une surveillance sentinelle de la LGV etait mise en place. 
La plupart des centres participants etaient situes a Paris ou Bordeaux. Seuls les cas confirmes de LGV rectale etaient pris en compte dans cette surveillance. Des prelevements rectaux positifs par PCR pour C. trachomatis etaient envoyes au Centre national de reference des infections a Chlamydia pour proceder au genotypage. Des donnees epidemiologiques de base fournies par les medecins traitants ainsi que les resultats du genotypage etaient adresses a l’Institut de veille sanitaire (InVS), ou les donnees etaient enregistrees anonymement. 
Fin decembre 2005, un total de 328 souches rectales de C. trachomatis isolees chez des hommes ont ainsi ete genotypees et 244 (74%) appartenaient au genotype L2. Aucun genotype L1 ou L3 n’a ete identifie. 
Un diagnostic a ete etabli retrospectivement pour 46 cas. L’âge median des patients atteints de LGV etait de 39 ans. Le statut par rapport au VIH etait connu pour 96 patients : 82/96 (85%) etaient infectes par le VIH. La majorite des cas de LGV (92%) ont ete diagnostiques en region parisienne. Parmi les autres souches (26%) de C. trachomatis, les genotypes Da et G etaient les plus frequents. 
Comme pour la syphilis ces dernieres annees, l’emergence de la LGV en Europe touche essentiellement les homosexuels masculins infectes par le VIH. Le depistage et le traitement des IST devraient faire partie du suivi clinique de cette population.
Transplantation of wild-type mouse hematopoietic stem and progenitor cells ameliorates deficits in a mouse model of Friedreich’s ataxia
Authors: Celine J. Rocca, Spencer M. Goodman, Jennifer N. Dulin, Joseph H. Haquang, Ilya Gertsman, Jordan Blondelle, Janell L. M. Smith, Charles J. Heyser, Stephanie Cherqui
Journal: Science Translational Medicine (2017)

YG8R mice, a model of Friedreich’s ataxia, show amelioration of the disease phenotype when transplanted with wild-type mouse hematopoietic stem and progenitor cells.
Ethyl Glucuronide in Hair Is an Accurate Biomarker of Chronic Excessive Alcohol Use in Patients With Alcoholic Cirrhosis
Authors: Jef Verbeek, Cleo L. Crunelle, Gil Leurquin-Sterk, Peter P. Michielsen, Mireille De Doncker, Diethard Monbaliu, Jacques Pirenne, Tania Roskams, Schalk van der Merwe, David Cassiman, Hugo Neels, Frederik Nevens
Journal: Clinical Gastroenterology and Hepatology (2017)
TCT-621 Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation in acute coronary syndrome: pooled-analysis of 3 randomization studies
Authors: Ji-Yong Jang, Dong-Ho Shin, Jung-Sun Kim, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Kyung Woo (KW) Park, Hyeon-Cheol Gwon, Hyo-Soo Kim, Yangsoo Jang
Journal: Journal of the American College of Cardiology (2017)