Calcium Intake and Cardiovascular Disease Risk
Authors: Joshua R. Lewis, Richard L. Prince
Journal: Annals of Internal Medicine (2017)

Letters2 May 2017Calcium Intake and Cardiovascular Disease RiskJoshua R. Lewis, PhD and Richard L. Prince, MDJoshua R. Lewis, PhDFrom University of Sydney, Sydney, New South Wales, and University of Western Australia, Perth, Western Australia, Australia.Search for more papers by this author and Richard L. Prince, MDFrom University of Sydney, Sydney, New South Wales, and University of Western Australia, Perth, Western Australia, Australia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0133 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We agree that Chung and colleagues' meta-analysis (1) and the guideline from the National Osteoporosis Foundation and American Society for Preventive Cardiology (2) provide only moderate-quality evidence that calcium supplements with or without vitamin D are safe in terms of cardiovascular and cerebrovascular disease, mortality, or all-cause mortality in generally healthy adults. Of note, the guideline acknowledges that future high-quality studies may improve our confidence in the estimates. Given the widespread use of these supplements and the clinical uncertainty, further high-quality studies are warranted.Margolis and Manson's editorial (3) on what clinicians and patients need to know ...References1. Chung M, Tang AM, Fu Z, Wang DD, Newberry SJ. Calcium intake and cardiovascular disease risk: an updated systematic review and meta-analysis. Ann Intern Med. 2016;165:856-66. [PMID: 27776363]. doi:10.7326/M16-1165 LinkGoogle Scholar2. Kopecky SL, Bauer DC, Gulati M, Nieves JW, Singer AJ, Toth PP, et al. Lack of evidence linking calcium with or without vitamin D supplementation to cardiovascular disease in generally healthy adults: a clinical guideline from the National Osteoporosis Foundation and the American Society for Preventive Cardiology. Ann Intern Med. 2016;165:867-8. [PMID: 27776362]. doi:10.7326/M16-1743 LinkGoogle Scholar3. Margolis KL, Manson JE. Calcium supplements and cardiovascular disease risk: what do clinicians and patients need to know?. Ann Intern Med. 2016;165:884-5. [PMID: 27776361]. doi:10.7326/M16-2193 LinkGoogle Scholar4. Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Pr; 2011. Google Scholar5. Grey A, Bolland M. Web of industry, advocacy, and academia in the management of osteoporosis. BMJ. 2015;351:h3170. [PMID: 26198274] doi:10.1136/bmj.h3170 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Sydney, Sydney, New South Wales, and University of Western Australia, Perth, Western Australia, Australia.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0133. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCalcium Intake and Cardiovascular Disease Risk Mei Chung , Alice M. Tang , Zhuxuan Fu , Ding Ding Wang , and Sydne Jennifer Newberry Calcium Intake and Cardiovascular Disease Risk Elizabeth J. Samelson Calcium Intake and Cardiovascular Disease Risk Ian R. Reid , Alison Avenell , Andrew Grey , and Mark J. Bolland Calcium Intake and Cardiovascular Disease Risk Mei Chung , Alice M. Tang , and Sydne Jennifer Newberry Calcium Intake and Cardiovascular Disease Risk Aisawan Petchlorlian Metrics Cited byHigh calcium intake in men not women is associated with all-cause mortality risk: Melbourne Collaborative Cohort Study 2 May 2017Volume 166, Issue 9Page: 685-686KeywordsCalciumClinical trial reportingDisclosureElderlyForecastingMortalityOsteoporosisPrevention, policy, and public healthRisk managementVitamin D ePublished: 2 May 2017 Issue Published: 2 May 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...