tbuckley/cabot-search huggingface dataset:
Effect of a Hospital-wide Measure on the Readmissions Reduction Program
Authors: Rachael B. Zuckerman, Karen E. Joynt Maddox, Steven H. Sheingold, Lena M. Chen, Arnold M. Epstein
Journal: New England Journal of Medicine (2017)

The Hospital Readmissions Reduction Program penalizes hospitals that have high 30-day readmission rates across specific conditions. There is support for changing to a hospital-wide readmission measure to broaden hospital eligibility and provide incentives for improvement across more conditions.We used Medicare claims from 2011 through 2013 to evaluate the number of hospitals that were eligible for penalties, in that they met a volume threshold of 25 admissions over a 3-year period for a specific condition or 25 admissions over a 1-year period for the cohorts included in the hospital-wide measure. We estimated the expected effects that changing from the condition-specific readmission measures to a hospital-wide measure would have on average penalties for safety-net hospitals (i.e., hospitals that treat a large proportion of low-income patients) and other hospitals.Our sample included 6,807,899 admissions for the hospital-wide measure and 4,392,658 admissions for the condition-specific measures. Of 3443 hospitals, 688 were considered to be safety-net hospitals. Changing to the hospital-wide measure would result in 76 more hospitals being eligible to receive penalties. The hospital-wide measure would increase penalties (mean [±SE] Medicare payment reductions across all hospitals) from 0.42±0.01% to 0.89±0.01% of Medicare base diagnosis-related-group payments. It would also increase the disparity in penalties between safety-net hospitals and other hospitals from -0.03±0.02 to 0.41±0.06 percentage points.A transition to a hospital-wide readmission measure would only modestly increase the number of hospitals eligible for penalties and would substantially increase the penalties for safety-net hospitals.
Deficiency of Current Acute Myeloid Leukemia (AML) Response Criteria to Predict Response to Hypomethylating Agent Therapy: The Value of Long-Lasting Stable Disease
Authors: Stephanie Williams, Rama Nanah, Darci Zblewski, Michelle Elliott, William J. Hogan, Raoul Tibes, James M. Foran, Mark R. Litzow, Aref Al-Kali
Journal: Blood (2016)
A tendência internacional dos serotipos de salmonella de 1998 a 2003 – um relatório da Rede de vigilância Enter-net
Authors: I. S.T. Fisher
Journal: Eurosurveillance (2004)

Um dos objectivos de toda actividade de vigilância consiste em seguir a evolucao das infeccoes. Desde 1993, a Rede internacional de vigilancia das infeccoes entericas humanas, Enter-net, recolhe e publica dados sobre as infeccoes humanas por salmonella confirmadas por laboratorio. O numero de casos identificados aumentou em meados da decada de 90, atingindo o maximo em 1997. Este artigo descreve a diminuicao posterior dos serotipos de salmoneras notificados entre 1998 e 2003 pelos laboratorios nacionais de referencia que participam nesta Rede de vigilância. Durante este periodo, o numero total de casos humanos baixou de 220.698 a 142.891. A pesar de este decrescimo, as salmonelloses siguem sendo uma das principais causas de morbilidade humana.
Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss
Authors: Samuel J. Barnes, Eleonora Franzoni, R. Irene Jacobsen, Ferenc Erdelyi, Gabor Szabo, Claudia Clopath, Georg B. Keller, Tara Keck
Journal: Neuron (2017)
Changing antimalarial agents after inefficacy or intolerance in patients with cutaneous lupus erythematosus: A multicenter observational study
Authors: François Chasset, Laurent Arnaud, Marie Jachiet, Jean-Benoît Monfort, Jean-David Bouaziz, Florence Cordoliani, Martine Bagot, Annick Barbaud, Camille Francès
Journal: Journal of the American Academy of Dermatology (2017)
Phase II trial of pembrolizumab in patients with platinum refractory germ-cell tumors: a Hoosier Cancer Research Network Study GU14-206
Authors: N. Adra, L.H. Einhorn, S.K. Althouse, N.R. Ammakkanavar, D. Musapatika, C. Albany, D. Vaughn, N.H. Hanna
Journal: Annals of Oncology (2017)
TCT-587 In-hospital switching between adenosine diphosphate receptor inhibitors in patients with acute coronary syndrome treated with percutaneous coronary intervention
Authors: M. Chadi Alraies, Homam Moussa Pacha, Kyle Buchanan, Toby Rogers, Fahed Darmoch, Edward Koifman, None Arie Steinvil, Rebecca Torguson, Linzhi Xu, Itsik Ben-Dor, Augusto Pichard, Lowell Satler, Ron Waksman
Journal: Journal of the American College of Cardiology (2017)
Using siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation in psoriasis
Authors: Houshang Nemati, Mohammad-Hosein Ghahramani, Reza Faridi-Majidi, Babak Izadi, Gholamreza Bahrami, Seyed-Hamid Madani, Gholamreza Tavoosidana
Journal: Journal of Controlled Release (2017)
An analysis of the risk of toxicity associated with participation in phase 1 oncology trials of novel molecularly targeted agents (mta) at the drug development unit, royal marsden hospital
Authors: SM Alam, Rudolf Fehrmann, D Olmos Hidalgo, K Shah, M Puglisi, L Trani, D Sarker, M Blanco, R Baird, R Molife
Journal: Annals of Oncology (2010)
Just four UK postgraduate surgical training posts meet national quality standards, study finds
Authors: Abi Rimmer
Journal: BMJ (2017)

Only four early years postgraduate surgical training posts in the UK meet nationally approved minimum quality standards, researchers have found. They have called for the Joint Committee on Surgical Training to act urgently to tackle stark deficiencies in surgical training.

The analysis by the Association of Surgeons in Training and the British Orthopaedic Trainees’ Association looked at the training of doctors working at the …
La pandemia di influenza e il piano di allerta in Germania
Authors: R Fock, H Bergmann, H Bußmann, G Fell, E J Finke, U Koch, M Niedrig, M Peters, K Riedmann, D Scholz, A Wirtz
Journal: Eurosurveillance (2002)

Il quadro concettuale descritto in questo articolo e servito di base alla decisione presa in comune dai ministri della sanita dei 16 stati federali tedeschi di mettere in atto un piano d'allerta per la pandemia di influenza. Sono stati usati i dati della pandemia di influenza spagnola del 1918-20 come scenario piu catastrofico. Abbiamo determinato i gruppi prioritari per la vaccinazione, come pure gli antivirali potenzialmente disponibili. Le politiche nazionali trarrebbero sicuro beneficio da una strategia europea comune.
La rubéola en Inglaterra, Escocia y Gales
Authors: P Tookey
Journal: Eurosurveillance (2004)

Desde 1970, la vacuna contra la rubeola se ofrece a las ninas en edad escolar, y asimismo durante los anos setenta se realizaron pruebas prenatales y vacunacion postparto de las mujeres susceptibles. La vacunacion masiva de ninos de 12 a 15 meses con la triple virica (MMR) se introdujo en 1988; en 1996 se suspendio la vacunacion de ninas en edad escolar y se sustituyo por una segunda dosis de MMR en ninos de edad preescolar; la vacunacion postparto de mujeres susceptibles identificadas mediante pruebas prenatales prosigue. Desde 1988, la rubeola es una enfermedad de declaracion obligatoria que se vigila a traves de informes clinicos y microbiologicos; se dispone de datos sobre interrupciones de embarazos asociadas a la rubeola y nacimientos con rubeola congenita (RC), susceptibilidad a la rubeola en subgrupos poblacionales y reaccion a la vacuna. Los casos declarados de RC disminuyeron de unos 50 anuales en 1971-75 a poco mas de 20 anuales en 1986-90, y las interrupciones de embarazos asociadas a la rubeola, de una media de 750, a 50 anuales. Desde 1991 se han declarado unos 40 ninos con RC; casi una tercera parte de sus madres se contagio en el extranjero, casi todas ellas en su pais de origen (infecciones importadas), un tercio nacio en el extranjero pero contrajo la infeccion en el Reino Unido y un tercio nacio en este pais. Las mujeres residentes en el RU nacidas en el extranjero presentan unas tasas de susceptibilidad a la rubeola mucho mas elevadas que las mujeres nacidas en este pais. Aunque actualmente hay escasa circulacion de la infeccion por rubeola, la reaccion a la vacuna MMR bajo en mas del 10% desde 1995. Si la rubeola comienza a circular otra vez, las mujeres inmigrantes tendran un mayor riesgo de contraer la infeccion durante el embarazo.
Chronic Creatine-deficiency is not the Underlying Cause of Cardiac Dysfunction in Mice Lacking the Creatine Biosynthetic Enzyme Arginine: glycine Amidinotransferase
Authors: C A Lygate, K M Faller, D J Medway, S Zervou, Choe C-U., D Isbrandt, J E Schneider, S Neubauer
Journal: Circulation (2013)

Background: Arginine:glycine amidinotransferase catalyses the first step in creatine biosynthesis, such that AGAT knockout (KO) mice fed a creatine-free diet have whole body creatine-deficiency. Un...
TCT-269 PFO Closure is Superior to Medical Therapy for Cryptogenic Stroke: a meta-analysis of randomised controlled trials
Authors: Yousif Ahmad, Matthew Shun-Shin, James Howard, Christopher Cook, Ricardo Petraco, Ozan Demir, Ghada Mikhail, Nilesh Sutaria, Chris Baker, Justin Davies, Jamil Mayet, Darrel Francis, Iqbal Malik, Sayan Sen
Journal: Journal of the American College of Cardiology (2017)
Studies in Carcinogenesis. XVI. Production of Subcutaneous Tumors in Mice by Miscellaneous Polycyclic Compounds&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: M. J. Shear, Joseph Leiter
Journal: JNCI Journal of the National Cancer Institute (1941)

Journal Article Studies in Carcinogenesis. XVI. Production of Subcutaneous Tumors in Mice by Miscellaneous Polycyclic Compounds Get access M. J. Shear, M. J. Shear principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph Leiter Joseph Leiter assistant chemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 3, December 1941, Pages 241–258, https://doi.org/10.1093/jnci/2.3.241 Published: 01 December 1941
Interventions and Outcomes in Children With Hypoplastic Left Heart Syndrome Born in England and Wales Between 2000 and 2015 Based on the National Congenital Heart Disease Audit
Authors: Libby Rogers, Christina Pagel, Ian D. Sullivan, Muhammed Mustafa, Victor Tsang, Martin Utley, Catherine Bull, Rodney C. Franklin, Katherine L. Brown
Journal: Circulation (2017)
Complement Activation in Peritoneal Dialysis–Induced Arteriolopathy
Authors: Maria Bartosova, Betti Schaefer, Justo Lorenzo Bermejo, Silvia Tarantino, Felix Lasitschka, Stephan Macher-Goeppinger, Peter Sinn, Bradley A. Warady, Ariane Zaloszyc, Katja Parapatics, Peter Májek, Keiryn L. Bennett, Jun Oh, Christoph Aufricht, Franz Schaefer, Klaus Kratochwill, Claus Peter Schmitt
Journal: Journal of the American Society of Nephrology (2017)

Cardiovascular disease (CVD) is the leading cause of increased mortality in patients with CKD and is further aggravated by peritoneal dialysis (PD). Children are devoid of preexisting CVD and provide unique insight into specific uremia- and PD-induced pathomechanisms of CVD. We obtained peritoneal specimens from children with stage 5 CKD at time of PD catheter insertion (CKD5 group), children with established PD (PD group), and age-matched nonuremic controls (n=6/group). We microdissected omental arterioles from tissue layers not directly exposed to PD fluid and used adjacent sections of four arterioles per patient for transcriptomic and proteomic analyses. Findings were validated in omental and parietal arterioles from independent pediatric control (n=5), CKD5 (n=15), and PD (n=15) cohorts. Transcriptomic analysis revealed differential gene expression in control versus CKD5 arterioles and in CKD5 versus PD arterioles. Gene ontology analyses revealed activation of metabolic processes in CKD5 arterioles and of inflammatory, immunologic, and stress-response cascades in PD arterioles. PD arterioles exhibited particular upregulation of the complement system and respective regulatory pathways, with concordant findings at the proteomic level. In the validation cohorts, PD specimens had the highest abundance of omental and parietal arteriolar C1q, C3d, terminal complement complex, and phosphorylated SMAD2/3, a downstream effector of TGF-β Furthermore, in the PD parietal arterioles, C1q and terminal complement complex abundance correlated with the level of dialytic glucose exposure, abundance of phosphorylated SMAD2/3, and degree of vasculopathy. We conclude that PD fluids activate arteriolar complement and TGF-β signaling, which quantitatively correlate with the severity of arteriolar vasculopathy.
Perfil y evolución de la quimiosensibilidad al paludismo por P. falciparum importado en Francia en 2000
Authors: P Ralaimazava, R Durand, N Godineau, A Keundjian, Z Jezic, B Pradines, O Bouchaud, J Le Bras
Journal: Eurosurveillance (2002)

En 2000, la quimiosensibilidad al paludismo importado en Francia fue estable. Si se tienen en cuenta todos los paises de infeccion, la doble resistencia a la cloroquina y el cicloguanil no ha cambiado desde 1996 hasta 2000. La monoterapia a base de quinina o mefloquina sigue siendo el primer tratamiento contra el paludismo por P. falciparum. La resistencia a estos dos antipaludicos en Africa no es frecuente ni ha evolucionado durante los ultimos 15 anos.
Medical schools should be prioritising nutrition and lifestyle education
Authors: Kate Womersley, Katherine Ripullone
Journal: BMJ (2017)

Would you expect a junior doctor to be confident giving basic advice and care for the most common and fatal diseases? Of course you would. The National Institute for Health and Care Excellence guidelines state that a first line intervention for diabetes, obesity, and high cholesterol is to give ‘lifestyle advice’—but this phrase is so vague that it is left up to doctors and patients to define it and, potentially, ignore it.

In 2008 and 2009, more than 75% of American junior physicians felt inadequately trained to counsel patients on diet and physical activity.1 The picture is reportedly similar in the UK.2 In Tomorrow’s Doctors, the General Medical Council requires qualifying medical students to understand the role of diet in health promotion and disease prevention, which includes being nutritionally competent. Internationally, this knowledge is lacking in medical training. Just 27% of US medical schools provided the agreed minimum of 25 hours of nutrition education in 2008.3 A recent study of European medical schools was slightly more optimistic, suggesting that nutrition education was a requirement in 68.8% of …
Interruzione della trasmissione del morbillo autoctono confermata in Catalogna, Spagna
Authors: L Salleras, A Domínguez, N Torner
Journal: Eurosurveillance (2001)

Da novembre 1998 a dicembre 2000, sono stati registrati in Catalogna (6.090.040 abitanti) 84 casi sospetti di morbillo. Dei 73 casi testati in laboratorio (87%), 20 mostravano anticorpi IgM specifici per morbillo e 3 erano epidemiologicamente collegati a un caso confermato. Tra questi 23 casi confermati, 13 erano autoctoni, gli ultimi due casi registrati datavano da giugno 1999 a luglio 2000. Questi risultati confermano il successo del programma di eliminazione del morbillo messo in atto in Catalogna nel 1998.
Salvage chemotherapy versus best supportive care in patients with recurrent or metastatic squamous cell carcinoma of the esophagus refractory or intolerable to fluorouracil, platinum, and taxane.
Authors: Takahiro Tsushima, Motoo Nomura, Satoru Iwasa, Ken Kato, Hirofumi Yasui, Kei Muro, Narikazu Boku
Journal: Journal of Clinical Oncology (2015)

e15101 Background: Survival benefit of chemotherapy (CTx) comparing with best supportive care (BSC) is unclear in patients with recurrent or metastatic esophageal squamous cell carcinoma (R/M ESCC) previously treated with fluorouracil (FU), platinum (PT), and taxane (Tax). Methods: The data of consecutive 285 patients with R/M ESCC, who were refractory or intolerable to all three drugs (FU, PT, and Tax) between March 2003 and November 2014, was retrospectively reviewed. Patient selection criteria were: age 20 – 75; PS 0 – 2; preserved organ function. Overall survival (OS), defined as survival time from the last administration of all three drugs, was analyzed using Kaplan-Meier method and Cox proportional hazard models. Results: Of eligible patients, 147 received BSC (BSC group) and 138 did CTx (CTx group: PT containing regimen 38; investigational drugs 29; irinotecan containing regimen 26; taxanes 25; FU 16; others 4). Some of patient characteristics were significantly different between BSC and CTx groups (age ≥ 65 years, 44% vs. 30%; PS 0 or 1/2, 74/26% vs. 93/7%; bone metastases, 15% vs. 8%; pleural effusion, 42% vs. 29%; central venous nutrition, 8% vs. 1%; gastric feeding, 11% vs. 4%). Most of patients were refractory to all three drugs (FU, 97% vs. 96%; PT, 95% vs. 93%; Tax, 85% vs. 93%, respectively in BSC and CTx group). The median OS was 4.2 months in BSC group and 7.8 months in CTx group (unadjusted HR 0.41; 95% CI 0.31 – 0.53). Propensity score matched analysis showed that median OS in CTx was significantly longer than that in BSC group (HR was 0.39; 95% CI 0.23-0.65). Multivariate analysis indicated 4 independent factors related to OS (shown in the Table). Conclusions: This analysis showed CTx was a significant factor for longer prognosis, and it is speculated that CTx might have a survival benefit even for R/M ESCC patients refractory or intolerable to FU, PT, and Tax. Multivariate analysis for OS HR (95% CI) P CTx 0.46 (0.32 – 0.66) < .001 Metastasis other than lymph node, lung, liver, or bone 1.54 (1.03 – 2.32) .038 CRP ≥ 1.0 mg/dL 1.57 (1.09 – 2.25) .015 Sum of diameter of target lesions ≥ 50 mm 1.50 (1.10 – 2.04) .011
Systematic Review for the 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death
Authors: Fred M. Kusumoto, Kent R. Bailey, Ahmad Sami Chaouki, Abhishek J. Deshmukh, Sandeep Gautam, Robert J. Kim, Daniel B. Kramer, Litsa K. Lambrakos, Naseer H. Nasser, Dan Sorajja
Journal: Journal of the American College of Cardiology (2017)
Effectiveness of dose reduced THP-COP like therapy with the addition of etoposide for elderly DLBCL patients
Authors: Yuko Tanaka, Seiichiro Yoshizawa, Yu Saito, Seiichiro Katagiri, Daigo Akahane, Hiroaki Fujimoto, Tetsuzo Tauchi, Yoshikazu Ito, Kazuma Ohyashiki
Journal: Annals of Oncology (2017)
Phase 1b study of first-line Ramucirumab + Platinum + Fluoropyrimidine in Japanese Patients with advanced gastric cancer
Authors: Shigenori Kadowaki, Kohei Shitara, Daisuke Sakai, Tomohiro Nishina, Reigetsu Yoshikawa, Yongzhe Piao, Akichika Ozeki, Koichi Inoue, Kei Muro
Journal: Annals of Oncology (2017)
Human plasmacytoid dendritic cells acquire phagocytic capacity by TLR9 ligation in the presence of soluble factors produced by renal epithelial cells
Authors: Jurjen M. Ruben, Gina Stella García-Romo, Eytan Breman, Sandra van der Kooij, Anke Redeker, Ramon Arens, Cees van Kooten
Journal: Kidney International (2017)
NO and HNO donors, nitrones, and nitroxides: Past, present, and future
Authors: Catarina Oliveira, Sofia Benfeito, Carlos Fernandes, Fernando Cagide, Tiago Silva, Fernanda Borges
Journal: Medicinal Research Reviews (2017)

Abstract The biological effects attributed to nitric oxide ( • NO) and nitroxyl (HNO) have been extensively studied, propelling their array of putative clinical applications beyond cardiovascular disorders toward other age‐related diseases, like cancer and neurodegenerative diseases. In this context, the unique properties and reactivity of the N‐O bond enabled the development of several classes of compounds with potential clinical interest, among which • NO and HNO donors, nitrones, and nitroxides are of particular importance. Although primarily studied for their application as cardioprotective agents and/or molecular probes for radical detection, continuous efforts have unveiled a wide range of pharmacological activities and, ultimately, therapeutic applications. These efforts are of particular significance for diseases in which oxidative stress plays a key pathogenic role, as shown by a growing volume of in vitro and in vivo preclinical data. Although in its early stages, these efforts may provide valuable guidelines for the development of new and effective N‐O‐based drugs for age‐related disorders. In this report, we review recent advances in the chemistry of NO and HNO donors, nitrones, and nitroxides and discuss its pharmacological significance and potential therapeutic application.
Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images
Authors: Daniel M. Spagnolo, Yousef Al-Kofahi, Peihong Zhu, Timothy R. Lezon, Albert Gough, Andrew M. Stern, Adrian V. Lee, Fiona Ginty, Brion Sarachan, D. Lansing Taylor, S. Chakra Chennubhotla
Journal: Cancer Research (2017)

We introduce THRIVE (Tumor Heterogeneity Research Interactive Visualization Environment), an open-source tool developed to assist cancer researchers in interactive hypothesis testing. The focus of this tool is to quantify spatial intratumoral heterogeneity (ITH), and the interactions between different cell phenotypes and noncellular constituents. Specifically, we foresee applications in phenotyping cells within tumor microenvironments, recognizing tumor boundaries, identifying degrees of immune infiltration and epithelial/stromal separation, and identification of heterotypic signaling networks underlying microdomains. The THRIVE platform provides an integrated workflow for analyzing whole-slide immunofluorescence images and tissue microarrays, including algorithms for segmentation, quantification, and heterogeneity analysis. THRIVE promotes flexible deployment, a maintainable code base using open-source libraries, and an extensible framework for customizing algorithms with ease. THRIVE was designed with highly multiplexed immunofluorescence images in mind, and, by providing a platform to efficiently analyze high-dimensional immunofluorescence signals, we hope to advance these data toward mainstream adoption in cancer research. Cancer Res; 77(21); e71-74. ©2017 AACR.
Aumento de la sífilis en Finlandia relacionado con la epidemia rusa
Authors: E Hilthunen-Back, O Haikala, P Koskela, T Reunala
Journal: Eurosurveillance (1996)

A principios de los anos 90 se notificaban anualmente entre 30 y 40 casos de serologia confirmada para sifilis en Finlandia. Los pacientes de sifilis tipicos eran hombres heterosexuales que adquirian la infeccion en el extranjero. Desde 1993, La incidencia de sifilis ha aumentado (ver figura). En 1995, se diagnostico un total de 118 casos nuevos, lo que representa casi el doble de los casos de 1994 (63 casos). El 37 % del total de los pacientes diagnosticados en 1995 fueron mujeres, el 77 % de los cuales se infectaron en Finlandia. El 65 % de los hombres diagnosticados en 1995 se infectaron en el extranjero, el 51 % en Rusia (1). La mayor parte de los casos en 1995 se localizaron en el sur de Finlandia o en el sudeste, cerca de la frontera rusa. (2). Se descubrio un agrupamiento de 30 casos en la zona central de Finlandia, en la ciudad de Tampere. El origen de este brote local fueron tres hombres que habian adquirido la infeccion en Rusia.