Mid- and Long-Term Health Risks in Living Kidney Donors
Authors: Linda M. O'Keeffe, Anna Ramond, Emanuele Di Angelantonio
Journal: Annals of Internal Medicine (2018)

Letters21 August 2018Mid- and Long-Term Health Risks in Living Kidney DonorsLinda M. O'Keeffe, PhD, Anna Ramond, DPharm, and Emanuele Di Angelantonio, MDLinda M. O'Keeffe, PhDUniversity of Bristol, Bristol, United Kingdom (L.M.O.)Search for more papers by this author, Anna Ramond, DPharmUniversity of Cambridge and National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Cambridge, United Kingdom (A.R.)Search for more papers by this author, and Emanuele Di Angelantonio, MDUniversity of Cambridge, National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, and National Health Service Blood and Transplant, Cambridge, United Kingdom (E.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0341 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Our systematic review and meta-analysis involving 52 studies with more than 100 000 living kidney donors found that there is no evidence of increased risk for adverse psychosocial outcomes, mortality, or major chronic diseases (such as cardiovascular disease or type 2 diabetes) among donor compared with nondonor populations. Living kidney donation is associated with a higher relative risk for end-stage renal disease and preeclampsia, but the absolute risk for these outcomes remains low.Drs. Mjoen and Holdaas correctly note that the length of follow-up differed among the studies included in our meta-analysis of all-cause mortality. The overall mortality estimate ...References1. Berger JC, Muzaale AD, James N, Hoque M, Wang JM, Montgomery RA, et al. Living kidney donors ages 70 and older: recipient and donor outcomes. Clin J Am Soc Nephrol. 2011;6:2887-93. [PMID: 22034505] doi:10.2215/CJN.04160511 CrossrefMedlineGoogle Scholar2. Segev DL, Muzaale AD, Caffo BS, Mehta SH, Singer AL, Taranto SE, et al. Perioperative mortality and long-term survival following live kidney donation. JAMA. 2010;303:959-66. [PMID: 20215610] doi:10.1001/jama.2010.237 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Bristol, Bristol, United Kingdom (L.M.O.)University of Cambridge and National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Cambridge, United Kingdom (A.R.)University of Cambridge, National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, and National Health Service Blood and Transplant, Cambridge, United Kingdom (E.D.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-1235. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMid- and Long-Term Health Risks in Living Kidney Donors Linda M. O'Keeffe , Anna Ramond , Clare Oliver-Williams , Peter Willeit , Ellie Paige , Patrick Trotter , Jonathan Evans , Jonas Wadström , Michael Nicholson , Dave Collett , and Emanuele Di Angelantonio Mid- and Long-Term Health Risks in Living Kidney Donors Geir Mjoen and Hallvard Holdaas Metrics 21 August 2018Volume 169, Issue 4Page: 265-266KeywordsChronic kidney diseaseDisclosureKidneysMortalityPopulation statisticsRenal diseasesRenal failureRisk managementTransplantationType 2 diabetes ePublished: 21 August 2018 Issue Published: 21 August 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...