tbuckley/cabot-search huggingface dataset:
Abstract P5-23-03: Gene expression profiling in male breast cancer
Authors: E Dubrovsky, S Raymond, J Chun, F Schnabel
Journal: Cancer Research (2018)

Abstract Background: Tumor gene expression profiling tests are widely used to quantify risk of recurrence of breast cancer and guide systemic therapy in early stage breast cancer. These assays have not been well validated in a male cohort. The purpose of this study was to determine the current rates of genomic testing in male breast cancer (MBC), the distribution of risk of recurrence scores (RRS) in early stage MBC, and the effect of RRS on systemic treatment patterns. Methods: The National Cancer Database was queried and found to include 6,227 cases of pathologic T1/T2 and N0/N1 MBC from 2008-2014 with known genomic testing status. Of the 1478 (23.74%) male patients who had gene expression profiling performed, variables of interest included age at diagnosis, stage, estrogen receptor status (ER), RRS, and treatment. We compared the treatment patterns of the 1,343 patients who had RRS available and the 4,527 patients who were not tested. A similar analysis was performed in female breast cancer (FBC) patients to serve as a point of reference. Statistical analysis included multivariate logistic regression and Pearson's chi-square test. Results: Of the 1,478 (23.74%) cases of MBC who had gene expression profiling, the most significant variables included: younger age, non-Black race, diagnosis after 2010, tumor Grade II, Estrogen Receptor (ER) positivity, and N0 or N1mi disease. Of those who had results, the distribution of RRS was 59.3% low, 27.4% intermediate, and 13.3% high. A similar distribution was found in 154,705 women who were tested during the same study period. Risk scores in men were significantly associated with tumor grade and size, but not nodal status. 83.4% of men with a low RRS were treated with hormone therapy alone, with an adjusted odds ratio (AOR) of 7.18 (CI 5.78-8.91, p&amp;lt;0.001). Also, 61.8% of men with a high RRS received combination chemotherapy and hormone therapy, with an AOR of 5.16 (CI 3.60-740, p&amp;lt;0.001). Conclusion: Although there is limited literature supporting the use of genomic assays in MBC, our study found similar rates of testing in men and women with early stage breast cancer. Treatment patterns varied significantly based on risk stratification, implying that physicians are using gene profiling assays to help guide treatment in MBC. Understanding the role for genomic profiling in MBC is particularly important as these results will be incorporated into the new AJCC 8th edition staging system. Long term follow up is needed to determine whether these tests accurately predict prognosis and recurrence in a male cohort. Citation Format: Dubrovsky E, Raymond S, Chun J, Schnabel F. Gene expression profiling in male breast cancer [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P5-23-03.
3D multi-scale FCN with random modality voxel dropout learning for Intervertebral Disc Localization and Segmentation from Multi-modality MR Images
Authors: Xiaomeng Li, Qi Dou, Hao Chen, Chi-Wing Fu, Xiaojuan Qi, Daniel L. Belavý, Gabriele Armbrecht, Dieter Felsenberg, Guoyan Zheng, Pheng-Ann Heng
Journal: Medical Image Analysis (2018)
COMPARISON OF TR BAND REMOVAL PROTOCOLS IN REDUCING OCCURRENCE OF RADIAL ARTERY OCCLUSION AMONG PATIENTS UNDERGOING LEFT HEART CATHETERIZATION: A RANDOMIZED CONTROL TRIAL
Authors: Farhala Baloch, Muhammad Rahman, Azmina Artani, Huma Fatima, Abdus Salam, Sher Ahmed
Journal: Journal of the American College of Cardiology (2018)
Impact of QuickFISH in addition to antimicrobial stewardship on vancomycin use and resource utilization in cancer patients with coagulase-negative staphylococcal blood cultures
Authors: S.K. Seo, Z. Gedrimaite, A. Paskovaty, K. Seier, S. Morjaria, N. Cohen, E. Riedel, Y.W. Tang, N.E. Babady
Journal: Clinical Microbiology and Infection (2018)
<i>JAMA Psychiatry</i>—The Year in Review, 2017
Authors: Dost Öngür, Stephan Heckers
Journal: JAMA Psychiatry (2018)

The year 2017 has been one of continued success for JAMA Psychiatry.The journal received ever-growing numbers of submissions but continued favorable patterns of timely and responsive handling of submitted manuscripts despite this larger volume.The number of major manuscripts we received reached 1313, an all-time high (Table ).We reject more than two-thirds of
Outcomes of patients (pts) with metastatic clear-cell renal cell carcinoma (mCCRCC) treated with second-line (2L) vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) after first-line (1L) immune checkpoint inhibitors (ICI).
Authors: Amishi Yogesh Shah, Emily Lemke, Jianjun Gao, Anuradha Chandramohan, Matthew T. Campbell, Amado J. Zurita, Lianchun Xiao, Jennifer Wang, Paul Gettys Corn, Eric Jonasch, Padmanee Sharma, Nizar M. Tannir
Journal: Journal of Clinical Oncology (2018)

682 Background: Little data exists on objective response rates (ORR), progression-free survival (PFS), and safety of 2L VEGFR-TKI after 1L ICI therapy in pts with mCCRCC. Methods: This is a retrospective study of pts with mCCRCC who received 2L VEGFR-TKI after progressive disease (PD) with 1L ICI. Tumor response was assessed by a blinded radiologist using RECIST 1.1. Descriptive statistics, the Fisher’s test, and Kaplan-Meier method were used. Results: We report on 43 pts who were treated at MDACC from 2015 till present. Median age at mCCRCC diagnosis was 59 years (range: 43-72). 33 pts had lung mets, 20 had LN mets, 14 had bone mets, and 3 had liver mets. As 1L therapy, 20 pts received nivolumab + ipilimumab, 14 received nivolumab + bevacizumab, and 9 received nivolumab. Median time on ICI therapy was 29.4 weeks. All pts had resolution of Grade 3/4 AEs from ICI and PD before initiation of VEGFR-TKI. One patient (2%) had CR, 17 pts (40%) had PR, and 25 pts (58%) had SD, leading to 100% disease control rate (DCR) as best response to 2L VEGFR-TKI. Median PFS was 10.0 months (95% CI: 7.4, NA). Estimated 1-yr overall survival (OS) was 87.5% (95% CI: 74.6 - 100). Seven pts (16%) discontinued VEGFR-TKI therapy because of AEs: Gr 3 transaminitis (3 on pazopanib), Gr 3 hand-foot skin reaction (1 on axitinib), impaired wound healing (1 on axitinib), and Gr 3 pancreatitis (1 on pazopanib, 1 on axitinib). Conclusions: In this retrospective study, we observed a 42% ORR, a 10-month median PFS, and a 100% DCR in pts with mCCRCC who received VEGFR-TKI after PD with ICI. These results inform the design of trials with 2L VEGFR-TKI after failure of ICI therapy. [Table: see text]
Abstract P2-07-08: Prognostic relevance of claudins 4 and 7 in invasive breast carcinoma (NOS) subtypes: A large tissue microarray study
Authors: AF Logullo, RM Rocha, M Stiepcich, FA Soares, FS Pasini, S Nonogaki, MM Brentani
Journal: Cancer Research (2018)

Abstract Molecular phenotyping has improved the understanding of a wide range of breast cancer disease. Recently, a new molecular subtype denominated “claudin-low” (CL) was described in breast cancer and correlated to worse prognosis and to CD44+/24- stem cell profile. Among 19 known claudin proteins, isotypes 4 (CL4) and 7 (CL7) are the most common in the breast biology. Objective: To verify differences in CL4 and CL7 immunoexpression between Luminal A, HER-2, and triple negative breast cancer phenotypes; and their association to CD44/24 status and tumor prognosis. Design: Estrogen and progesterone receptor status (ER/PR), HER-2, CL4 and CL7 expression and CD44/24 profiles were evaluated in 803 invasive ductal breast carcinomas arranged into four tissue microarrays (TMA) and results were correlated with prognosis and important clinical data. Results: 503 (62.6%) cases were positive for CL4 and 369 (46.0%) cases for CL7. The majority (199/283, 70.3%) of CL4 negative cases were clustered in the luminal A subtype whereas 63 (22.3%) showed triple negative profile and the remaining 21 cases (7.4%) exhibited positive HER-2 expression (p&amp;lt;0.001). Claudin 7 negative samples (44.2%) tended to follow the same pattern. CL4 positive expression was significantly associated to HER-2 expression, presence of lymph nodes and increased tumor grades and inversely correlated to ER and PR expression. However, there was no association between CL7 expression and any of these features. Both CL4 and CL7 did not show correlation to the stem cell markers (CD44+/CD24-) or worse prognosis (survival and disease-free interval). Conclusion: Claudins 4 and 7 immunoexpression did not provide additional prognostic information within breast cancer subtypes. Citation Format: Logullo AF, Rocha RM, Stiepcich M, Soares FA, Pasini FS, Nonogaki S, Brentani MM. Prognostic relevance of claudins 4 and 7 in invasive breast carcinoma (NOS) subtypes: A large tissue microarray study [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P2-07-08.
American Heart Association Precision Medicine Platform
Authors: Taha A. Kass-Hout, Laura M. Stevens, Jennifer L. Hall
Journal: Circulation (2018)

ntegrating the open science movement with impactful discoveries in science, velocity of technology, and raw power of cloud computing has led to an unprecedented opportunity for scientific discovery.The American Heart Association recently established the Precision Medicine Platform 1 through the efforts of multiple American Heart Association volunteers and a collaboration with Amazon Web Services.The cloud-based platform, powered by Amazon Web Services and available at https://precision.heart.org,was founded on the FAIR principles (findable, accessible, interoperable, and reusable) 2 and includes secure collaboration areas (workspaces) and an open sharing area.The goals of the platform are to democratize data, to make it easy to search across orthogonal data sets, to provide a secure workspace to leverage the power of cloud computing, and to provide a forum for users to share insights.Multiple learning tools are available, including video tutorials, templates using open interactive programming framework, and a forum for interaction among community members. 3
The Global HIV Epidemic
Authors: Ingrid T. Katz, Peter Ehrenkranz, Wafaa El-Sadr
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intermediate-dose cytarabine plus mitoxantrone versus standard-dose cytarabine plus daunorubicin for acute myeloid leukemia in elderly patients
Authors: C. Röllig, M. Kramer, M. Gabrecht, M. Hänel, R. Herbst, U. Kaiser, N. Schmitz, J. Kullmer, S. Fetscher, H. Link, L. Mantovani-Löffler, U. Krümpelmann, T. Neuhaus, F. Heits, H. Einsele, B. Ritter, M. Bornhäuser, J. Schetelig, C. Thiede, B. Mohr, M. Schaich, U. Platzbecker, K. Schäfer-Eckart, A. Krämer, W.E. Berdel, H. Serve, G. Ehninger, U.S. Schuler
Journal: Annals of Oncology (2018)
A Parkinson’s disease specialist
Authors: Srimathy Vijayan
Journal: BMJ (2008)

We used to understand Parkinson’s disease as a condition characterised by motor symptoms: tremor, rigidity, and bradykinesia. Recently we have started to think of it as a multisystem disorder with significant “non-motor symptoms” including depression, dementia, and constipation, which have considerable impact on quality of life.

The clinical phenomenology of the condition is fascinating. The late Sir David Marsden, with his infectious interest and attention to clinical detail, was inspirational.

The sense of satisfaction you get when you are able to control debilitating symptoms and help patients lead a more normal life. The time spent with patients, listening to them and observing their different problems, can be very rewarding.

A little closer perhaps—cure implies both arresting the process and repairing …
What are the realistic implications of finding a job for somebody who has been convicted of a minor charge? If it is too difficult to find a medical job, should I give up looking for jobs in the UK?
Authors: Rebecca Fitzgerald
Journal: BMJ (2006)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
THE ROLE OF QUANTITATIVE AORTOGRAPHIC ASSESSMENT OF AORTIC REGURGITATION IN THE GUIDANCE OF TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Yosuke Miyazaki, Mohammad Abdelghani, Hiroki Tateishi, Rafael Cavalcante, Carlos Collet, Taku Asano, Yuki Katagiri, Erhan Tenekecioglu, Rogerio Sarmento-Leite, José Mangione, Alexandre Abizaid, Osama Soliman, Yoshinobu Onuma, Pedro Lemos, Fabio De Brito, Patrick Serruys
Journal: Journal of the American College of Cardiology (2018)
Nottingham systematic review course
Authors: Uzair Ahmed
Journal: BMJ (2009)

The course is hosted by the Cochrane Schizophrenia Group for those interested in undertaking reviews of randomised trials. The Cochrane Schizophrenia Group is part of the Cochrane Collaboration, an international, non-profit organisation that publishes systematic reviews of healthcare interventions. New reviewers are encouraged to attend this course. It is not specialty specific and will attract anyone wishing to do a Cochrane style review.

This was a four day course that involved small group work, interactive tutorials, workshops, and practical computer sessions. The first two days were a gentle introduction to the Cochrane Collaboration, focusing on developing and writing a …
Metaplastic Cdx2-depleted cells can be very disruptive neighbors
Authors: Filipe C. Lourenço, Douglas J. Winton
Journal: The Journal of Experimental Medicine (2018)

In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring “normal” Cdx2-positive cells.
Could you please give me more information with regards to holiday pay as a locum?
Authors: Adam Harrison
Journal: BMJ (2004)

<i>Got a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone (www.bmjcareers.com/advicezone) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site.</i>
Author Correction: CRISPR interference-based specific and efficient gene inactivation in the brain
Authors: Yi Zheng, Wei Shen, Jian Zhang, Bo Yang, Yao-Nan Liu, Huihui Qi, Xia Yu, Si-Yao Lu, Yun Chen, Yu-Zhou Xu, Yun Li, Fred H. Gage, Shuangli Mi, Jun Yao
Journal: Nature Neuroscience (2018)
Married same sex couples could face same NHS pension discrimination as widowers
Authors: Abi Rimmer
Journal: BMJ (2014)

Proposed changes to the NHS pension scheme could mean that married same sex couples face the same discrimination in survivor benefits as widowers of female doctors and civil partners.1

A consultation on the proposed amendments closed in December, and they have now been laid before parliament.

Proposed amendments to the scheme would give married same sex couples the same rights as civil partners, but these couples would still suffer the same discrimination as that currently faced by widowers of female doctors. The first same sex marriages will be allowed in England and Wales from …
Primary and metastatic brain cancer genomics and emerging biomarkers for immunomodulatory cancer treatment
Authors: F. Passiglia, C. Caglevic, E. Giovannetti, JA. Pinto, P. Manca, S. Taverna, A. Listì, I. Gil-Bazo, LE. Raez, A. Russo, C. Rolfo
Journal: Seminars in Cancer Biology (2018)
Sharing of patient data didn’t breach rules, says public health agency
Authors: Jacqui Wise
Journal: BMJ (2018)

Public Health England has criticised media reports that it handed over the medical records of thousands of patients with cancer to a firm working for the tobacco multinational Philip Morris International, saying that newspapers had presented a “very distorted view of the facts.”

The Telegraph reported on 14 January that anonymised data covering 179 040 lung tumours diagnosed between 2009 and 2013 in England were given to William E Wecker Associates without the consent of any of the patients concerned or their families.1 The company has testified on behalf of tobacco companies in dozens of lawsuits. The report was then picked up by other newspapers, including the Daily Mail , Sun , Independent , and Daily Express .

Public Health England said that any data were completely anonymised and that its action was fully in line with guidance …
Characterization of biomarkers to immune checkpoint blockade therapy across solid tumors.
Authors: Meaghan Russell, Xiu Huang, Dana Vuzman, Maria Lvova, Angeliki Pantazi, Stephen Lyle, Julie Y Tse
Journal: Journal of Clinical Oncology (2018)

26 Background: Immune checkpoint blockade (ICB) therapy has been effective patients with solid tumors. Currently, tumor expression of programmed death-ligand 1 (PD-L1) is clinically used as a biomarker of predicted response to ICBs in non-small cell lung cancer (NSCLC). However, across solid tumors, only a subset of patients benefit from ICBs, so there is need to identify other biomarkers to predict response to ICB. We investigated the use of large panel next generation sequencing (NGS) to characterize biomarkers to ICBs across solid tumors. Methods: NGS and PD-L1 immunohistochemistry (IHC) was performed on a series of solid tumors. NGS analysis included detection of single nucleotide polymorphisms (SNPs), insertions and deletions (indels), copy number variation (CNV), and gene-fusions in 435 cancer-related genes, microsatellite instability (MSI), tumor mutational burden (TMB) based on non-synonymous SNPs, and HPV16/18 and EBV viral status. Genomic alterations in previously reported biomarkers of response to ICBs were assessed. Results: 143 solid tumors were analyzed with NGS and PD-L1 IHC. The samples included 80 NSCLC, 15 colorectal carcinoma, 8 cutaneous melanoma, 6 breast carcinoma, and 34 other solid tumors. The mean TMB varied by tumor type, with the highest in melanoma. The frequency of PD-L1 expression was higher in NSCLC and melanoma compared to colorectal carcinoma. The relationship between PD-L1 expression and the other biomarkers varied by tumor type (Table 1). Positive association (+); Negative association (-): No association (None). Conclusions: We characterized biomarkers to ICBs across a range of solid tumors. We found tumor-specific differences in the mean TMB and frequency of PD-L1 expression. We also found tumor-specific differences in the associations between PD-L1 and other potential biomarkers, including KRAS, NRAs, HRAs, BRAF, and EGFR mutation status. We found no correlation between PD-L1 expression and MSI and viral status. NGS is an efficient platform for analysis of biomarkers in solid tumors.[Table: see text]
THE ASSOCIATION OF ACUTE CORONARY SYNDROME AND CORONARY PLAQUE FEATURES BY SEX: THE ICONIC STUDY
Authors: Jessica Peña, Leslee Shaw, Fay Lin, Daniele Andreini, Filippo Cademartiri, Kavitha Chinnaiyan, Benjamin Chow, Ricardo Cury, Gudrun Feuchtner, Martin Hadamitzky, Yong-Jin Kim, Jonathon Leipsic, Hugo Marques, Gianluca Pontone, Todd Villines, Daniel Berman, Matthew Budoff, Jeroen J. Bax, James K. Min, Hyuk-Jae Chang
Journal: Journal of the American College of Cardiology (2018)
Developing a research website for trainees
Authors: Phyo K Myint
Journal: BMJ (2005)

When they discovered that many junior doctors interested in research didn9t know how to get started, <b>Alasdair MacLullich</b>, <b>Miles Witham</b>, and <b>Phyo Myint</b> decided to develop a website to help them. Here they describe how they did it
Chronic breathlessness: re-thinking the symptom
Authors: Miriam J. Johnson, Janelle Yorke, John Hansen-Flaschen, Magnus Ekström, David C. Currow
Journal: European Respiratory Journal (2018)

<b>Chronic breathlessness: designation as a clinical syndrome to encourage clinicians to ask patients routinely if they are living with this neglected and often invisible symptom and, if so, how it impacts on their lives</b>http://ow.ly/QqtY30iWKSb
Tissue Regeneration: 3D Maskless Micropatterning for Regeneration of Highly Organized Tubular Tissues (Adv. Healthcare Mater. 3/2018)
Authors: Chi Ma, Tiejun Qu, Bei Chang, Yan Jing, Jerry Q. Feng, Xiaohua Liu
Journal: Advanced Healthcare Materials (2018)

In article number 1700738, Xiaohua Liu and co-workers develop biomimetic 3D matrices with highly-organized tubular architecture to guide stem cell migration and differentiation. When using this tubular matrix as a scaffold, functional tubular dentin is successfully regenerated with the same well-organized microstructure as its natural counterpart. This approach provides a powerful avenue for the regeneration of functional tissues with well-organized structures.
Postgraduate Diploma in Child and Adolescent Mental Health
Authors: Imran Mushtaq
Journal: BMJ (2008)

It is designed for social workers, nurses, special needs teachers, GP practice counsellors, primary child mental health workers, psychologists, and psychiatrists who work with children or adolescents with mental health problems. It may be of particular interest to recent graduates of social or behavioural sciences by providing a sound knowledge base and professional training in the area of child and adolescent mental health.

I did it in 2004-5, part time over two years, one day a week. The timing of the taught sessions is ideal for those working full time as classes are held from 3 …
Ill medical patients’ acute care and treatment (IMPACT)
Authors: Dipesh H Vasant, Syed Ishaq Husain
Journal: BMJ (2008)

This two day course, designed by the Federation of Royal Medical Colleges and the Royal College of Anaesthetists, is aimed at trainees working in medicine.

November 2007, towards the end of our first foundation year 2 rotations.

We both intend to apply for core medical training and wished to demonstrate our commitment to the specialty. There are many courses available to help develop acute care skills and knowledge, but this is the only course endorsed by the Royal College of Physicians. In our foundation jobs we were constantly faced with acutely …