tbuckley/cabot-search huggingface dataset:
Empagliflozin and Assessment of Lower-Limb Amputations in the EMPA-REG OUTCOME Trial
Authors: Silvio E. Inzucchi, Hristo Iliev, Egon Pfarr, Bernard Zinman
Journal: Diabetes Care (2017)

Sodium–glucose cotransporter 2 (SGLT2) inhibitors are oral glucose-lowering agents indicated for the treatment of type 2 diabetes. In the CANagliflozin cardioVascular Assessment Study (CANVAS) Program, the SGLT2 inhibitor canagliflozin was associated with an increased risk for lower-limb amputation (LLA) (including minor and major amputation) versus placebo (hazard ratio [HR] 1.97 [95% CI 1.41, 2.75]) in patients with type 2 diabetes and high cardiovascular risk (1). In the EMPA-REG OUTCOME trial in patients with type 2 diabetes and established cardiovascular disease (2), the proportion of patients with LLA was similar between those treated with empagliflozin and placebo (3). We report further analyses of LLA in the EMPA-REG OUTCOME trial.

Any hospital admission during the EMPA-REG OUTCOME trial was to be reported as a serious adverse event. Investigators were asked to provide a detailed narrative with additional medical information for each serious adverse event. From the EMPA-REG OUTCOME trial database, we identified LLA via a systematic search of serious adverse event narratives, from events reported as adverse events, and from those reported as a “medical procedure” under “concomitant therapy” in electronic case report forms or in investigator comments describing adverse events. All cases identified were medically reviewed to confirm an LLA event. Time to first LLA was analyzed using a …
The retrieval of at least 25 lymph nodes should be essential for advanced gastric cancer patients with lymph node metastasis: A retrospective analysis of single-institution database study design: Cohort study
Authors: Bochao Zhao, Jiale Zhang, Xiuxiu Chen, Tianmin Sun, Zhenning Wang, Huimian Xu, Baojun Huang
Journal: International Journal of Surgery (2017)
Abstract 14642: Cardiac-specific Transgenic Inhibition of NF-kB Attenuates Apoptosis and Remodeling in the Aging Heart
Authors: Sheng Ye, Guangming Cheng, Jifei Tang, Xing Chen, Lin Zhao, Anweshan Samanta, Magdy Girgis, Robert Vincent, Yanjuan Yang, Jeryl Hauptman, Buddhadeb Dawn
Journal: Circulation (2015)

Introduction: Aging increases the risk of cardiovascular diseases. Remodeling of the aged heart involves slow yet progressive loss of functional cardiomyocytes, reactive hypertrophy of the remaining cardiomyocytes, and increased fibrosis. NF-κB is one of the major transcription factors that have been linked to cardiovascular disease. Although NF-kB activity increases with aging and aging-related chronic diseases, its role in cardiomyocyte apoptosis and remodeling of the aging heart remains unclear. Hypothesis: We hypothesized that myocardial NF-kB signaling would aggravate ventricular remodeling in the aging heart. Methods: We used transgenic mice overexpressing a mutant IkBα that prevents NF-kB activation. Cardiac structure and function were assessed by echocardiography and morphometry in young (10-week-old) and aged (86-week-old) IkBα transgenic (Tg) mice and non-transgenic (NTg) littermates. Cardiomyocyte apoptosis and molecular regulators of apoptosis were quantified to gain molecular insights. Results: Compared with young NTg mice, aged NTg mice exhibited greater LV mass and LV end-diastolic volume (Fig). This age-related remodeling was significantly blunted in Tg hearts in the absence of myocardial NF-κB activation. The percentage of apoptotic cardiomyocyte nuclei in aged NTg myocardium was significantly higher compared with young NTg and young Tg hearts. Apoptosis was significantly attenuated in aged Tg hearts compared with aged NTg hearts. This decrease in cardiomyocyte apoptosis was corroborated by reduced Bax/Bcl-2 ratio in aged Tg hearts (Fig). Conclusions: We conclude that myocardial NF-kB signaling plays a detrimental role during cardiac aging process, and cardiac-specific NF-kB inhibition protects against cardiomyocyte apoptosis and age-associated LV remodeling. These molecular insights may be utilized to develop novel therapeutic strategies for cardiovascular diseases in the aging population.
Le varie tipologie di intossicazione alimentare e di fonti di contaminazione
Authors: N Noah
Journal: Eurosurveillance (1999)

Le tre forme di intossicazione alimentare descritte in questo numero di Eurosurveillance tratteggiano la straordinaria propensione degli organismi a sopravvivere e a provocare malattie. Il Clostridium botulinum e un organismo che produce una tossina (una tossina che, inoltre, viene distrutta piuttosto facilmente dal calore) solamente se si crea una precisa ed insolita combinazione di condizioni ambientali. L'articolo dalla Polonia sul botulismo, insieme a quelli pubblicati nel numero di Gennaio, dimostrano che questa combinazione, sebbene sia rara, e ancora molto diffusa. Normalmente, di fronte ad un focolaio di Salmonella enteritidis, si ritiene che i responsabili siano pollame o uova. Il rapporto proveniente dalla Grecia ha concluso che la maionese, fatta con uova crude e conservata a 15°C, era il piu probabile veicolo d'infezione e mostra come la contaminazione delle uova di gallina con questo organismo sia diffusa in tutta Europa.
Exercise-based intervention for prevention of sports injuries (PEDro synthesis)
Authors: Priscilla Viana Silva, Steven J Kamper, Luciola da Cunha Menezes Costa
Journal: British Journal of Sports Medicine (2017)

Exercise-based intervention has been shown effective in treating and preventing many health conditions.1 Sporting activities are one way that people can engage in physical activity; however, injuries can be a negative consequence of engaging in sport.2 Along with providing a disincentive to participation, studies have shown high costs associated with the management of sports injuries.2 There is evidence, however, that specific injury prevention programmes can be accessible and are potentially effective for all kinds of athletes.3 In order to make recommendations regarding injury prevention, it is important to understand the effectiveness of different types of injury prevention programmes.3 

The primary aim of this systematic review was to estimate the effectiveness of physical activity-based interventions for prevention of sports injuries in adults and/or adolescents. Second, to determine whether strength training, stretching, proprioception and combinations of these have different effects on …
Abstract 15875: Relationship Between Door to Balloon Time Variability and Outcomes in Patients With ST Elevation Myocardial Infarction
Authors: Chetan Huded, Samir Kapadia, Kathleen Kravitz, Travis Gullett, Scott Hantz, Stephen Ellis, Venu Menon, Mouin Abdallah, Seth Podolsky, Steve Meldon, Damon Kralovic, Deborah Brosovich, Elizabeth Smith, Umesh Khot
Journal: Circulation (2017)

Introduction: We aimed to determine the impact of a comprehensive STEMI protocol (CSP) on door to balloon time (D2BT) variability and patient outcomes. Methods: On 7/15/14 we implemented a CSP base...
FRI0186 Circadian profile of serum melatonin in patients with systemic sclerosis
Authors: AT Kotulska, L Brzezinska-Wcislo, EJ Kucharz
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Melatonin (MT) is secreted by the pineal gland and a circadian rhythm of MT secretion is related to light-darkness exposure. MT has been found to influence immune and endocrine functions and is a free radical scavanger. Immune abnormalities and disturbed endocrine secretion have been reported in patients with systemic sclerosis (SSc). Additionally, some of the patients have sleep disturbances or depression, a factors known to effect the MT level. All these findings suggest possible role of MT in pathogenesis of some phenomena seen in SSc patients. <h3>Objectives</h3> The aim of the study was to evaluate the circadian profile of serum MT levels in patients with SSc. <h3>Methods</h3> Six women with definite SSc, aged 32.4+1.8 yrs (symptoms duration 4–7 yrs) and six age-matched healthy women were investigated. Blood samples were drawn at 8.00, 12.00, 16.00, 20.00, 22.00, 24.00, 02.00, 04.00. 06.00. Light exposure of the subjects was from 07.30 to 21.00. MT was determined with ELISA method. <h3>Results</h3> A significant circadian rhythm of serum MT was detected in all investigated subjects. Serum MT levels were lower in the SSc patients than in the controls, MESOR = 21.4 pg/ml and 47.3 pg/ml, in the patients and controls, respectively. In the SSc patients, the night increase in MT was also relatively lower when compared to the daily levels. Maximal values were found between 02.00–04.00 both in the patients and controls. <h3>Conclusion</h3> The general nature of the circadian serum MT rhythm is maintained in the SSc patients although secretion of MT is depressed. The mechanism of impaired MT secretion remains unknown. It may be speculated that a low MT level is involved in development of immune abnormalities, neuroendocrine disfunctions and/or impaired free radical elimination. All these phenomena may contribute to development of fibrosis.
Las olas de calor de 2003 en Europa
Authors: T Kosatsky
Journal: Eurosurveillance (2005)

El numero actual de Eurosurveillance presenta datos adicionales a los notificados en el inicio de 2004, durante e inmediatamente despues de las olas de calor del verano de 2003 [1], con un exceso estimado de 22.080 muertes para Inglaterra y Gales, Francia, Italia y Portugal. Mientras casi no cambiaron las estimaciones para Inglaterra y Gales [2], Francia [3] y Portugal [4] comparadas con las informaciones previas, se deben anadir 6.595-8.648 defunciones en exceso para Espana [5], de las cuales el 54%, o sea entre 3.574 y 4.687, ocurrieron en Agosto; asi como 1.400-2.200 en los Paises Bajos [6], de las cuales aproximadamente 500 fueron durante la ola de calor entre 31 de julio y 13 de agosto. Los datos para Italia, correspondientes aqui a las ciudades de Bolonia, Milan, Roma y Turin, son compatibles con las estimaciones anteriores, de 3.134 defunciones en 21 capitales regionales para el periodo entre 1 junio y 15 agosto [7]. Sin embargo, el Instituto nacional italiano de estadistica senalo un exceso de 19.780 defunciones en todo el pais entre junio y septiembre de 2003 comparado con 2002 [8]. Otros informes mencionan cerca de 1.250 defunciones ligadas a la ola de calor en Belgica durante el verano de 2003 [9], un exceso de 975 defunciones entre junio y agosto en Suiza [10], y de 1.410 entre el 1 y el 24 de Agosto en Baden-Wurttemberg (Alemania) [11]. Actualmente, se puede pensar que a la vista de la confirmacion de las defunciones asociadas a la ola de calor, entre Inglaterra y Gales, Francia, Italia y Portugal, el numero estimado de 22.080 defunciones en exceso en el inicio de agosto se tiene que revisar al alza y aumentar el 50% para toda Europa occidental. Este aumento se podria llevar hasta el 100% si fueran tomadas en cuenta las olas de calor de junio y julio 2003.
Impact of tobacco smoking prevalence on cardiovascular and non-cardiovascular deaths in England and Wales, 2017–40: a modelling study
Authors: Sara Ahmadi-Abhari, Maria Guzman-Castillo, Piotr Bandosz, Hannah Whittaker, Martin J Shipley, Mika Kivimäki, Archana Singh-Manoux, Simon Capewell, Martin O'Flaherty, Eric J Brunner
Journal: The Lancet (2017)
Prevalence of left ventricular systolic dysfunction in pre‐dialysis and dialysis patients with preserved left ventricular ejection fraction
Authors: Liselotte C.R. Hensen, Kathleen Goossens, Victoria Delgado, Rachid Abou, Joris I. Rotmans, J. Wouter Jukema, Jeroen J. Bax
Journal: European Journal of Heart Failure (2017)
Prescription Drug Monitoring Programs and Opioid Death Rates—Reply
Authors: Anne Schuchat, Gery P. Guy, Deborah Dowell
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vigilância de salmonelas: resultados e objectivos futuros
Authors: W van Pelt
Journal: Eurosurveillance (1999)

Este numero especial do Eurosurveillance refere-se ao progresso desenvolvido pela rede Enter-net na vigilância e gestao de surtos de salmonelose humana na Europa. Esta rede estabeleceu uma base internacional de dados, actualizada frequentemente, e uma colaboracao entre peritos que permitiu o sucesso de diversas accoes de saude publica na Europa. O artigo sobre a multirresistencia da Salmonella typhimurium, na Republica Checa, ilustra o interesse da recente extensao das actividades da rede a vigilância da resistencia antimicrobiana das salmonelas e da sua abertura a outros paises europeus.
Efficacy and safety of palbociclib plus endocrine therapy in women with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC) in the Asia-Pacific region: Data from PALOMA-2 and -3
Authors: S-A Im, N. Masuda, Y-H Im, K. Inoue, S-B Kim, A. Redfern, J. Lombard, D. Lu, K. Puyana Theall, E.G. Gauthier, H. Mukai, J. Ro
Journal: Annals of Oncology (2017)
Pneumocystosis revealing immunodeficiency secondary to <i>TERC</i> mutation
Authors: Raphael Borie, Caroline Kannengiesser, Flore Sicre de Fontbrune, David Boutboul, Laure Tabeze, Florence Brunet-Possenti, Elodie Lainey, Marie Pierre Debray, Aurélie Cazes, Bruno Crestani
Journal: European Respiratory Journal (2017)

Telomerase-related gene (TRG) mutations are evidenced in about 25% of patients with familial pulmonary fibrosis, and less frequently in sporadic interstitial lung disease (ILD) [1]. Even though TRG mutations can be associated with haematological, hepatic and cutaneous manifestations, most adult ILD patients with TRG mutations only present asymptomatic extrapulmonary involvement such as thrombocytopenia or premature hair greying [2]. However, some specific extrapulmonary manifestations such as immunodeficiency or portal hypertension can be severe and need early detection. We report herein the case of a patient with primary immunodeficiency revealed by pneumocystosis, which could have been misdiagnosed as an idiopathic acute exacerbation of ILD. TERC mutation may be associated with a primary immunodeficiency <http://ow.ly/zY7b30fWbD9>
Poor overall quality of clinical practice guidelines for musculoskeletal pain: a systematic review
Authors: Ivan Lin, Louise K Wiles, Robert Waller, Roger Goucke, Yusuf Nagree, Michael Gibberd, Leon Straker, Christopher G Maher, Peter P B O’Sullivan
Journal: British Journal of Sports Medicine (2017)

Objectives Undertake a systematic critical appraisal of contemporary clinical practice guidelines (CPGs) for common musculoskeletal (MSK) pain conditions: spinal (lumbar, thoracic and cervical), hip/knee (including osteoarthritis) and shoulder. Design Systematic review of CPGs (PROSPERO number: CRD42016051653). Included CPGs were written in English, developed within the last 5 years, focused on adults and described development processes. Excluded CPGs were for: traumatic MSK pain, single modalities (eg, surgery), traditional healing/medicine, specific disease processes (eg, inflammatory arthropathies) or those that required payment. Data sources and method of appraisal Four scientific databases (MEDLINE, Embase, CINAHL and Physiotherapy Evidence Database) and four guideline repositories. The Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument was used for critical appraisal. Results 4664 records were identified, and 34 CPGs were included. Most were for osteoarthritis (n=12) or low back pain (n=11), most commonly from the USA (n=12). The mean overall AGREE II score was 45% (SD=19.7). Lowest mean domain scores were for applicability (26%, SD=19.5) and editorial independence (33%, SD=27.5). The highest score was for scope and purpose (72%, SD=14.3). Only 8 of 34 CPGS were high quality: for osteoarthritis (n=4), low back pain (n=2), neck (n=1) and shoulder pain (n=1).
Impact on survival of pulmonary metastasectomy in colorectal cancer
Authors: M. Meri Abad, C. Avila Andrade, A.J. Cunquero Tomas, A. Rodriguez Huaman, A.B. Fernandez Diaz, L. Condori Farfan, I. Shaheen, M.J. Safont Aguilera, C. Caballero Diaz, V. Iranzo Gonzalez-Cruz, A. Blasco Cordellat, M.C. Godes Sanz de Bremond, A. Berrocal, V. Sforza, M. Gil Raga, C. Camps Herrero
Journal: Annals of Oncology (2017)
Abstract IA32: Metabolic syndrome and breast cancer risk among black women: An exercise intervention
Authors: Lucile L. Adams-Campbell
Journal: Cancer Research (2017)

Abstract Breast cancer rates, which are increasing worldwide, parallel the increases in lifestyle diseases including Type 2 diabetes, obesity, and metabolic syndrome (MetS). MetS represents a cluster of risk factors associated with increased risk of cardiovascular diseases, and includes several components individually related to breast cancer etiology, i.e., central obesity, hypertension, hyperglycemia, and low high-density lipoprotein cholesterol. Among Black women who have high rates of MetS and breast cancer mortality, it is hypothesized that lifestyle interventions on MetS may improve the MetS profile and reduce breast cancer risk. In the present randomized controlled trial (RCT) we compared two exercise interventions: a supervised facility-based and a home-based exercise intervention to a control group in Black women with MetS who are at increased risk for breast cancer (based on the CARE model). This 6-month three-arm RCT assesses the impact of the exercise interventions on biomarkers related to obesity, insulin-related pathways, inflammation, and hormones. The specific aim of the proposed study is to compare the impact of a supervised facility-based and a home-based exercise intervention on obesity, metabolic syndrome and known breast cancer biomarkers in postmenopausal Black women with MetS who are at increased risk of breast cancer. There was a total of N=213 women randomized to the 3 arms of the RCT comprising 73, 69, and 71 women in the supervised, home-based, and control groups. The data reveal that the home-based intervention arm results have more favorable changes in metabolic components compared to the supervised and control groups. These findings appear to have broad public health utility in addressing lifestyle interventions among Black women, with a successful home-based intervention. Citation Format: Lucile L. Adams-Campbell. Metabolic syndrome and breast cancer risk among black women: An exercise intervention [abstract]. In: Proceedings of the AACR International Conference: New Frontiers in Cancer Research; 2017 Jan 18-22; Cape Town, South Africa. Philadelphia (PA): AACR; Cancer Res 2017;77(22 Suppl):Abstract nr IA32.
Enhanced Synergism of Thermo-chemotherapy For Liver Cancer with Magnetothermally Responsive Nanocarriers
Authors: Minghua Li, Wenbo Bu, Jie Ren, Jianbo Li, Li Deng, Mingyuan Gao, Xiaolong Gao, Peijun Wang
Journal: Theranostics (2017)

A combination of magnetic hyperthermia and magnetothermally-facilitated drug release system was developed as a promising strategy for liver cancer therapy.The thermosensitive copolymer, 6sPCL-b-P(MEO2MA-co-OEGMA) shows a good temperature-controlled drug release response.Mn-Zn ferrite magnetic nanoparticles (MZF-MNPs) exhibit a strong magnetic thermal effect with an alternating magnetic field (AMF).Owing to its high magnetic sensitivity, the magnetothermally-responsive nanocarrier/doxorubicin (MTRN/DOX) can be concentrated in the tumor site efficiently through magnetic targeting.Given this information, we synthesized MTRN/DOX which was composed of MZF-MNPs, thermosensitive copolymer drug carriers, and the chemotherapeutic drug---DOX, to study its anticancer effects both in vitro and in vivo.METHODS: MTRN/DOX was designed and prepared.Firstly, we investigated the accumulation effects of MTRN/DOX by Prussian blue staining, transmission electron microscopy (TEM), laser scanning confocal microscopy (LSCM) and conducted 7.0 T MRI.Following this, the magnetothermal effects of MTRN/DOX were studied using an infrared thermal camera.DOX uptake, distribution, and retention in tumor cells and the distribution of MTRN/DOX in vivo were then analyzed via LSCM, flow cytometry and live fluorescence imaging.Lastly, its anticancer effects were evaluated by MTT, AM/PI staining, Annexin-VFITC/PI staining and comparison of relative tumor volume.RESULTS: We found that MTRN/DOX can be efficiently concentrated in the tumor site through magnetic targeting, increasing the uptake of DOX by tumor cells, and prolonging the retention time of the drug within the tumors.MTRN/DOX showed good magnetothermal effects both in vitro and in vivo.Based on the above results, MTRN/DOX had significant anticancer effects.CONCLUSIONS: MTRN/DOX causes temporal-spatial synchronism of thermo-chemotherapy and together with chemotherapeutic drugs, produces a synergistic effect, which enhances the sensitivity of tumor cells to DOX and reduces their side effects.
Psychosocial Intervention Improves Adherence to Antidepressants
Authors: Anita Slomski
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiple Hypermetabolic Subcutaneous Lesions From Hidradenitis Suppurativa Mimicking Metastases on 18F-FDG PET/CT
Authors: Philip Asamoah, Daniel J. Wale, Benjamin L. Viglianti, Ka Kit Wong, Milton Gross
Journal: Clinical Nuclear Medicine (2017)

Hidradenitis suppurativa is an inflammatory disease associated with subcutaneous nodules/abscesses that occur commonly in the axillary, inguinal, and perineal regions. We describe a case of a 64-year-old man presenting for F-FDG PET/CT for staging of a left vocal cord squamous cell carcinoma. The scan showed uptake in the left vocal cord malignancy and multiple hypermetabolic subcutaneous foci in the right axilla, right buttocks, and scalp in known locations of skin lesions related to hidradenitis suppurativa. This case illustrates an unusual inflammatory cause of F-FDG incidental uptake that should not be mistaken for metastases.