tbuckley/cabot-search huggingface dataset:
Reply to A. Piccardo et al, E. Hindié et al, M.C. Kreissl et al, M. Doss, J. Buscombe, R. Fisher, M. Sollini et al, M. Lichtenstein, and M. Tulchinsky et al
Authors: Remco J. Molenaar, Surbhi Sidana, Tomas Radivoyevitch, Aaron T. Gerds, Hetty E. Carraway, Matt Kalaycio, Aziz Nazha, David J. Adelstein, Christian Nasr, Jaroslaw P. Maciejewski, Navneed S. Majhail, Mikkael A. Sekeres, Sudipto Mukherjee
Journal: Journal of Clinical Oncology (2018)
One-year injecting frequency trajectories as predictors of hepatitis C acquisition: findings from an observational cohort study of people who inject drugs in Montréal, Canada
Authors: E. Fortier, M.-P. Sylvestre, A.A. Artenie, D. Justras-Aswad, R. Élise, J. Grebely, J. Bruneau
Journal: Journal of Hepatology (2018)
Efficacy and safety of direct-acting antivirals for 1,961 Japanese chronic hepatitis C patients – Real Word Data from a multicenter cohort
Authors: N. Furusyo, E. Ogawa, N. Hideyuki, K. Dohmen, N. Higashi, K. Takahashi, A. Kawano, K. Azuma, T. Satoh, M. Nakamuta, T. Koyanagi, M. Kato, S. Shimoda, E. Kajiwara, J. Hayashi
Journal: Journal of Hepatology (2018)
Fibroblast growth factor 23 and Klotho contribute to airway inflammation
Authors: Stefanie Krick, Alexander Grabner, Nathalie Baumlin, Christopher Yanucil, Scott Helton, Astrid Grosche, Juliette Sailland, Patrick Geraghty, Liliana Viera, Derek W. Russell, J. Michael Wells, Xin Xu, Amit Gaggar, Jarrod Barnes, Gwendalyn D. King, Michael Campos, Christian Faul, Matthias Salathe
Journal: European Respiratory Journal (2018)

Circulating levels of fibroblast growth factor (FGF)23 are associated with systemic inflammation and increased mortality in chronic kidney disease. α-Klotho, a co-receptor for FGF23, is downregulated in chronic obstructive pulmonary disease (COPD). However, whether FGF23 and Klotho-mediated FGF receptor (FGFR) activation delineates a pathophysiological mechanism in COPD remains unclear. We hypothesised that FGF23 can potentiate airway inflammation via Klotho-independent FGFR4 activation. FGF23 and its effect were studied using plasma and transbronchial biopsies from COPD and control patients, and primary human bronchial epithelial cells isolated from COPD patients as well as a murine COPD model. Plasma FGF23 levels were significantly elevated in COPD patients. Exposure of airway epithelial cells to cigarette smoke and FGF23 led to a significant increase in interleukin-1β release via Klotho-independent FGFR4-mediated activation of phospholipase Cγ/nuclear factor of activated T-cells signalling. In addition, Klotho knockout mice developed COPD and showed airway inflammation and elevated FGFR4 expression in their lungs, whereas overexpression of Klotho led to an attenuation of airway inflammation. Cigarette smoke induces airway inflammation by downregulation of Klotho and activation of FGFR4 in the airway epithelium in COPD. Inhibition of FGF23 or FGFR4 might serve as a novel anti-inflammatory strategy in COPD.
Abstract 17532: Impact of High Hepatic Wedge Pressure, Portal Hypertension, on Hemodynamics and Liver Function in Patients After the Fontan Operation
Authors: Jun Negishi, Hideo Ohuchi, Kanae Noritake, Yosuke Hayama, Osamu Sasaki, Tohru Iwasa, Aya Miyazaki, Osamu Sasaki
Journal: Circulation (2015)

Background: Fontan circulation may be, in part, characterized by portal hypertension that can be estimated by hepatic vein wedge pressure (HWP). Purpose: To evaluate associations of HWP in cosecutive 318 Fontan patients (18±7 years old) during catheterization and compared the results with the hemodynamics, liver function and the related plasma biomarkers. HWP significantly correlated positively with inferior vena cava pressure (IVCP), pulmonary artery resistance (Rp), ration of Rp to systemic artery resistance (Rs) (Rp/Rs), and cardiac index and negatively with Rs and arterial and mixed venous oxgen saturations. Of those, high IVCP, low Rp and high Rp/Rs were independently correlated with high HWP (p&lt;0.05 for all). As for the liver function, HWP significantly correlated positively with plasma levels of total bilirubin (TB), hyaluronic acid, and type IV collagen (TyIV) and negatively with plasma levels of albumin and cholinesterase (ChE). Of those, ChE, TB and TyIV were independently correlated with high HWP (p&lt;0.01 for all). High HWP, low ChE, and high TyIV significantly correlated with high plasma nitric oxide products (p&lt;0.01). Conclusion: High HWP associates with a significant reduction of Rp and Rs with preserved cardiac output. This unique Fontan circulation with Rs-dominant reduction may be due to both portal hypertension and overproduction of nitric oxide secondary to liver dysfunction.
Clinical presentation and survival of Asian and non-Asian patients with HBV-related hepatocellular carcinoma (HBV-HCC): Results of 767 United States patients with long-term follow-up
Authors: J. Hoang, P. Nguyen, J. Leong, J. Yang, A. Le, L. Roberts, M. Schwartz, M. Nguyen
Journal: Journal of Hepatology (2018)
Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2
Authors: Meidan Ying, Xuejing Shao, Hui Jing, Yujia Liu, Xiaotian Qi, Ji Cao, Yingqian Chen, Senfeng Xiang, Hua Song, Ronggui Hu, Guoqing Wei, Bo Yang, Qiaojun He
Journal: Blood (2018)
Next generation of immune checkpoint therapy in cancer: new developments and challenges
Authors: Julian A. Marin-Acevedo, Bhagirathbhai Dholaria, Aixa E. Soyano, Keith L. Knutson, Saranya Chumsri, Yanyan Lou
Journal: Journal of Hematology & Oncology (2018)

Immune checkpoints consist of inhibitory and stimulatory pathways that maintain self-tolerance and assist with immune response. In cancer, immune checkpoint pathways are often activated to inhibit the nascent anti-tumor immune response. Immune checkpoint therapies act by blocking or stimulating these pathways and enhance the body’s immunological activity against tumors. Cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), programmed cell death receptor-1 (PD-1), and programmed cell death ligand-1(PD-L1) are the most widely studied and recognized inhibitory checkpoint pathways. Drugs blocking these pathways are currently utilized for a wide variety of malignancies and have demonstrated durable clinical activities in a subset of cancer patients. This approach is rapidly extending beyond CTLA-4 and PD-1/PD-L1. New inhibitory pathways are under investigation, and drugs blocking LAG-3, TIM-3, TIGIT, VISTA, or B7/H3 are being investigated. Furthermore, agonists of stimulatory checkpoint pathways such as OX40, ICOS, GITR, 4-1BB, CD40, or molecules targeting tumor microenvironment components like IDO or TLR are under investigation. In this article, we have provided a comprehensive review of immune checkpoint pathways involved in cancer immunotherapy, and discuss their mechanisms and the therapeutic interventions currently under investigation in phase I/II clinical trials. We also reviewed the limitations, toxicities, and challenges and outline the possible future research directions.
Loss of BSEP protects MDR2/ABCB4 KO mice from cholestatic liver injury by altering bile acid profile and signaling
Authors: C. Fuchs, G. Paumgartner, V. Mlitz, S. Wolfrum, A. Wahlström, M. Ståhlman, T. Stojakovic, C. Wolfrum, H.-U. Marschall, M. Trauner
Journal: Journal of Hepatology (2018)
Ethical drug marketing criteria for the 21st century
Authors: Lisa Parker, Jane Williams, Lisa Bero
Journal: BMJ (2018)

Lisa Parker and colleagues call for WHO to expand and update its criteria for ethical drug promotion to take account of changing marketing practices The World Health Organization has a long history of promoting the rational use of drugs with the aim of improving health. One element of its multipronged approach is to use its authority1 to establish normative guidance on promotion. An early guidance document, drafted in 1968, focused on advertising of drugs. In 1988, it was updated in a new document, "Ethical criteria for medicinal drug promotion," which was endorsed through a resolution adopted by the World Health Assembly.2 Recommendations endorsed by the WHA are among the strongest guidances produced by WHO. The 1988 ethical criteria (box 1) were intended as guidance for countries to use when developing their regulations and practices around medicinal drug promotion.34 The document is still used by regulators, governments, and academics as a yardstick for measuring the acceptability of promotional activities.5678 The criteria have also been incorporated into curriculums for educating health professionals about drug marketing tactics.9 WHO guidance documents are particularly important in countries where local regulation is absent or insufficient. These countries are likely to receive increasing promotional attention from drug companies as the potential for market growth in high income countries shrinks.10 Box 1 ### Summary of WHO ethical criteria for medicinal drug promotion, 19882 #### Aim #### Definitions #### Intended audience #### SectionsRETURN TO TEXT
TCTAP A-108 Thrombus Burden Is Significantly Less in Drug-eluting Stent than in Bare Metal Stent at 3-week Follow-Up After ST-segment Elevation Myocardial Infarction: An Optical Coherence Tomography Study
Authors: Nobuhiro Sato, Yoshiyasu Minami, Takao Shimohama, Kameda Ryo, Taiki Tojo, Junya Ako
Journal: Journal of the American College of Cardiology (2018)
DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis
Authors: Qian Liu, Anping Li, Shengnan Yu, Shuang Qin, Na Han, Richard G. Pestell, Xinwei Han, Kongming Wu
Journal: Journal of Hematology & Oncology (2018)

Abstract Background C-X-C motif ligand 8 (CXCL8), known as a proinflammatory chemokine, exerts multiple effects on the proliferation, invasion, and migration of tumor cells via the autocrine or paracrine manner. Conversely, the human Dachshund homologue 1 (DACH1) is recognized as a tumor suppressor which retards the progression of various cancers. In prostate cancer, it has been demonstrated that DACH1 was negatively correlated with the expression of CXCL8 and able to antagonize the effects of CXCL8 on cellular migration. Herein, we explored the mechanisms by which DACH1 regulated the CXCL8 in non-small cell lung cancer (NSCLC). Methods Public microarray and Kaplan-Meier plotter datasets were analyzed. Blood serum samples from lung adenocarcinoma (ADC) patients were collected for enzyme-linked immunosorbent assay (ELISA) analysis. Immunohistochemical staining was conducted on tissue microarray. Cell lines with stable expression of DACH1 were established, and relative gene expression was measured by Western blot, ELISA, real-time PCR, and human cytokine array. Correspondingly, cell lines transfected with shDACH1 were established, and relative gene expression was measured by real-time PCR and immunofluorescence array. Functional studies were performed by transwell and xenograft mice models. Luciferase reporter gene assay was applied to measure the regulation of DACH1 on CXCL8. Results Our study indicated that CXCL8 both at the mRNA and protein level was associated with the high tumor burden of ADC. Correlational analyses in ADC cell lines and ADC tissues showed that DACH1 was inversely correlated with CXCL8. Meanwhile, patients with high DACH1 expression and low CXCL8 expression had prolonged time to death and recurrence. Moreover, we verified the inhibitory effects of DACH1 on CXCL8 both in vitro and in vivo. Mechanism studies proved that DACH1 transcriptionally repressed CXCL8 promoter activity through activator protein-1 (AP-1) and nuclear transcription factor-kappa B (NF-κB) sites. Conclusions Our study proved that CXCL8 acted as an unfavorable factor promoting to tumor progression and poor prognosis of ADC, while DACH1 antagonized CXCL8 to provide a favorable survival of ADC patients. Double detection of DACH1 and CXCL8 may provide a precise information for further evaluating the prognosis of ADC patients.
Case 14-2018: A 68-Year-Old Woman with a Rash, Hyponatremia, and Uveitis
Authors: Molly L. Paras, Emily P. Hyle, Ruth K. Foreman, K.C. Coffey
Journal: New England Journal of Medicine (2018)

A 68-year-old woman was admitted to the hospital because of a rash, hyponatremia, and anterior uveitis. The illness had begun 14 days earlier, during a trip to India. Diagnostic tests were performed.
Testing Ashkenazi Jewish Women for Mutations Predisposing to Breast Cancer in Genes Other Than <i>BRCA1</i> and <i>BRCA2</i>
Authors: Steven Narod, Victoria Sopik, Cezary Cybulski
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
What’s Next (Generation) for the Diagnosis of Chronic Meningitis?
Authors: Kenneth L. Tyler
Journal: JAMA Neurology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Alternative splicing regulation during the course of liver disease
Authors: H. Wang, B. Lekbaby, N. Fares, T. Attout, A. Schnuriger, A.-M.C. Doulcier, G. Panasyuk, J. Augustin, G. Perlemuter, I. Bieche, S. Vacher, J. Hall, P. Merle, D. Kremsdorf, I. Chemin, P. Soussan
Journal: Journal of Hepatology (2018)
Oxidized albumin present in patients with decompensated cirrhosis triggers the inflammatory response in peripheral leukocytes through the p38 MAP kinase pathway
Authors: J.A. Quiles, M. Casulleras, K. Oettl, E. Titos, R. Flores-Costa, C. Lopez-Vicario, M. Duran-Güell, M. Pavesi, R.E. Stauber, V. Arroyo, J. Clària
Journal: Journal of Hepatology (2018)
Prenatal exposure to sand and dust storms and children's cognitive function in China: a quasi-experimental study
Authors: Zhihui Li, Lincoln Chen, Mingqiang Li, Jessica Cohen
Journal: The Lancet Planetary Health (2018)

BackgroundWhile there is evidence that sand and dust storms can have adverse health effects, the effects of such storms on children's cognitive function has not been explored. We examined whether prenatal exposure to sand and dust storms affects children's cognitive function and, if so, whether harmful effects of sand and dust storms vary by the trimester of exposure.MethodsThis study used nationally representative data from the China Family Panel Studies between 2010 and 2014 and data on sand and dust storms from the national Sand and Dust Weather Almanac. We selected four indicators of children's cognitive function: mathematics test scores, word-recognition test scores, the age the child began speaking in whole sentences, and the age the child began counting from one to ten. Since the annual incidence of sand and dust storms is highly variable and is largely unpredictable, we used a region-and-year fixed-effect model to compare the cognitive function of children born in the same region and year but with varying amounts of prenatal exposure to sand and dust storms. We also investigated whether the effect of sand and dust storms varied by the specific month of prenatal exposure.FindingsWe included 1236 observations for the analysis of mathematics and word-recognition test scores, 2693 observations in the analysis of the age the child began speaking in whole sentences, and 1951 observations for the analysis of the age the child began counting from one to ten. Every 10 additional days of prenatal exposure to sand and dust storms was associated with a 0·20 SD (95% CI 0·06 to 0·35, p=0·009) reduction in word test scores, 0·04 (–0·00 to 0·09, p=0·089) additional months to begin speaking in sentences, and 0·14 (0·03 to 0·25, p=0·021) additional months to begin counting, but was not significantly associated with mathematics test scores (reduction of 0·02 SD, −0·19 to 0·15). 10 additional days of prenatal exposure to sand and dust storms in the seventh gestational month was associated with a 0·18 SD (0·10 to 0·25) reduction in mathematics test scores, a 0·34 SD (0·18 to 0·50) reduction in word test scores, an additional 0·33 months (0·07 to 0·59) to begin speaking in sentences, and an additional 0·20 months (0·04 to 0·35) to begin counting.InterpretationOur results suggest that protecting pregnant women from the effects of sand and dust storms in the critical periods of fetal brain development could generate benefits for the cognitive function of the next generation.FundingNone.
Reduction in tuberculosis incidence in the UK from 2011 to 2015: a population-based study
Authors: H Lucy Thomas, Ross J Harris, Morris C Muzyamba, Jennifer A Davidson, Maeve K Lalor, Colin N J Campbell, Sarah R Anderson, Dominik Zenner
Journal: Thorax (2018)

Following nearly two decades of increasing tuberculosis in the UK, TB incidence decreased by 32% from 2011 to 2015. Explaining this reduction is crucial to informing ongoing TB control efforts.We stratified TB cases notified in the UK and TB cases averted in the UK through pre-entry screening (PES) between 2011 and 2015 by country of birth and time since arrival. We used population estimates and migration data to establish denominators, and calculated incidence rate ratios (IRRs) between 2011 and 2015. We calculated the contribution of changing migrant population sizes, PES and changes in TB rates to the reduction in TB notifications.TB IRRs fell in all non-EU migrant and UK-born populations between 2011 and 2015 (0.61; 95% CI 0.59 to 0.64 and 0.78; 0.73 to 0.83 respectively), with the greatest decrease in recent non-EU migrants (0.54; 0.48 to 0.61). 61.9% of the reduction in TB notifications was attributable to decreases in TB rates, 33.4% to a fall in the number of recent/mid-term non-EU migrants and 11.4% to PES. A small increase in notifications in EU-born migrants offset the reduction by 6.6%.Large decreases in TB rates in almost all populations accounted for the majority of the reduction in TB notifications, providing evidence of the impact of recent interventions to improve UK TB control. The particularly large decrease in TB rates in recent non-EU migrants provides evidence of the effectiveness of screening interventions that target this population. These findings will inform ongoing improvements to TB control.
A Pap-Based Test to Detect Endometrial and Ovarian Cancers Early
Authors: Jennifer Abbasi
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ethical challenges in resuscitation
Authors: Spyros D. Mentzelopoulos, Anne-Marie Slowther, Zoe Fritz, Claudio Sandroni, Theodoros Xanthos, Clifton Callaway, Gavin D. Perkins, Craig Newgard, Eleni Ischaki, Robert Greif, Erwin Kompanje, Leo Bossaert
Journal: Intensive Care Medicine (2018)
Genome-wide characterization and analysis of bHLH transcription factors in Panax ginseng
Authors: Yang Chu, Shuiming Xiao, He Su, Baosheng Liao, Jingjing Zhang, Jiang Xu, Shilin Chen
Journal: Acta Pharmaceutica Sinica B (2018)

Ginseng (Panax ginseng C.A. Meyer) is one of the best-selling herbal medicines, with ginsenosides as its main pharmacologically active constituents. Although extensive chemical and pharmaceutical studies of these compounds have been performed, genome-wide studies of the basic helix-loop-helix (bHLH) transcription factors of ginseng are still limited. The bHLH transcription factor family is one of the largest transcription factor families found in eukaryotic organisms, and these proteins are involved in a myriad of regulatory processes. In our study, 169 bHLH transcription factor genes were identified in the genome of P. ginseng, and phylogenetic analysis indicated that these PGbHLHs could be classified into 24 subfamilies. A total of 21 RNA-seq data sets, including two sequencing libraries for jasmonate (JA)-responsive and 19 reported libraries for organ-specific expression analyses were constructed. Through a combination of gene-specific expression patterns and chemical contents, 6 PGbHLH genes from 4 subfamilies were revealed to be potentially involved in the regulation of ginsenoside biosynthesis. These 6 PGbHLHs, which had distinct target genes, were further divided into two groups depending on the absence of MYC-N structure. Our results would provide a foundation for understanding the molecular basis and regulatory mechanisms of bHLH transcription factor action in P. ginseng.
Sorafenib with versus without concurrent conventional transarterial chemoembolization (cTACE) in patients with advanced hepatocellular carcinoma (HCC): Results from a multicenter, open-label, randomized, controlled phase III STAH trial
Authors: J.-W. Park, Y.J. Kim, D.Y. Kim, S.H. Bae, S.W. Paik, Y.-J. Lee, D. Lee, H.C. Lee, S.Y. Han, J.Y. Cheong, O.S. Kwon, J.E. Yeon, B.H. Kim, J.-S. Hwang
Journal: Journal of Hepatology (2018)