tbuckley/cabot-search huggingface dataset:
SIDE- AND AGE-SPECIFIC POSTURAL ADAPTATIONS OF MALE ELITE JUNIOR SOCCER PLAYERS (UNDER 16, 17 &amp; 19)
Authors: Karen Hajduk, Dietmar Schmidtbleicher
Journal: British Journal of Sports Medicine (2017)

<h3>Background</h3> Playing soccer at professional level may induce functional and structural adaptations of the neuro-musculoskeletal system based on soccer specific movement coordination due to continuous asymmetrical loadings. This may predispose young athletes in particular to pathologic conditions and increased injury risk at early stages within their careers. <h3>Objective</h3> The purpose was to quantify the static standing profile. It was hypothesized that the alignment differs between limbs (footedness) and age groups. <h3>Design</h3> Experimental, prospective cohort study. <h3>Setting</h3> Biomechanical assessment in clinical practice. <h3>Patients (or Participants)</h3> 102 uninjured male elite junior soccer players aged between 16 and 19 years old reporting no former joint injury. <h3>Interventions (or Assessment of Risk Factors)</h3> Three-dimensional motion capture (SIMI Motion 3D) analysing the static standing profile. <h3>Main Outcome Measurements</h3> 3D kinematic data of the thoracic (TH 12) and lumbar spine (L3), pelvis and hips, knees and ankles bilateral, comprising 27 variables. <h3>Results</h3> Kinematic data indicate age-specific differences for the amount of thoracic extension, knee adduction and external rotation of the supporting leg (p&lt;0.05). Side-specific adaptations can be proven for functional scoliosis at the thoracolumbar junction and height of iliac crest (p&lt;0.05). K-means analyses show significant differences for hip abduction and external rotation for the kicking leg (p&lt;0.05). By means of correspondence analysis U19 players can be associated with lumbar scoliosis, knee varus for the supporting leg and knee valgus for the kicking leg. <h3>Conclusions</h3> The older the players, the more complex the functional postural adaptations. The results provide plausible explanations for increased injury risk of ACL injuries on the kicking leg, groin pain, and the need for more sophisticated injury prevention programs. From a methodological point of view, comprehensive 3D-static analysis using appropriate statistical analyses seems to be well suited for the assessment of postural deviations for large scale cohorts.
Beating, Fast and Slow
Authors: Sandeep M. Jani, Brahmajee K. Nallamothu, Leslie T. Cooper, Andrew Smith, Reza Fazel
Journal: New England Journal of Medicine (2017)

A 52-year-old man presented with a 2-week history of exertional chest discomfort, described as a sensation of fullness in the center of his chest without radiation, and dyspnea. He reported no chest discomfort at rest, light-headedness, or syncope.
Abstract #LB-206: Loss of accumulation of bortezomib-mediated polyubiquitinated proteins in acquired bortezomib-resistant mesothelioma cell line I-45
Authors: Lidong Zhang, Yu Cui, James Littlejohn, Xiaobo Cao, W. Smythe
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Proteasome inhibitor bortezomib is a novel anticancer drug that has exhibited strong antitumor activity against a wide range of malignancies. However, resistance to bortezomib may impede clinical use of this agent. In this study, to characterize mechanisms of bortezomib resistance and further develop strategies to overcome it, we developed a bortezomib-resistant cell line by repeated treatment of mesothelioma cell line I-45 with gradually increased concentrations of bortezomib (10-100 nM) and name it I-45-R cells. Continuous exposure to 50 nM bortezomib for three days, the cell viability in parental I-45 cells was below 12 %, while the cell viability in I-45-R cells was over 83 %. Compared with I-45 cells, I-45-R cells did not show significant bortezomib-mediated G2/M phase arrest. Autophagy did not account for bortezomib resistance, as I-45-R cells did not show the conversion of LC3 to the lower migrating form LC3-II in response to bortezomib treatment. Subsequent study showed that greatly accumulated ubiquitinated proteins including p53 were observed only in the parental I-45 cells, but not in the I-45-R cells after treatment with bortezomib. In addition, compared with parental I-45 cells, our study also showed significantly reduced accumulation of BH3-only pro-apoptotic protein NOXA in I-45-R cells. Our results suggest that incapability of accumulation of bortezomib-mediated polyubiquitinated proteins in I-45-R cells may reduce expression of key apoptosis-related genes, such as p53 and NOXA, thus leading to bortezomib resistance.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-206.
Yemen’s cholera epidemic may have peaked, says WHO
Authors: Owen Dyer
Journal: BMJ (2017)

Fatality rates have dropped for the first time in Yemen’s cholera outbreak, which has infected an estimated 219 000 people and killed over 1400 in two months, the World Health Organization said on 27 June.

WHO’s senior emergency adviser for Yemen, Ahmed Zouiten, said that, although the war has created a “perfect storm for cholera,” fatality rates have dropped from 1.7% in early May to 0.6% after intervention by health workers.

This week saw the first drop in new reported cases, he said: 39 000, down from a recent average of 41 000. But he warned that this apparent …
Prevention forecast: cloudy with a chance of injury
Authors: Nicol van Dyk, Benjamin Clarsen
Journal: British Journal of Sports Medicine (2017)

Imagine being able to predict the weather next winter with 100% accuracy. Impossible, right? Yet the belief that we can predict which athletes will get injured based on some form of screening test is not uncommon. The challenge of predicting injury prediction was a prevailing theme at the 2017 IOC World Conference on Prevention of Illness and Injury in Sport. As elucidated during Roald Bahr’s keynote lecture and in his paradigm-shifting BJSM publication,1 a reason why prediction is impossible is actually quite simple—current screening tests do not pass standard tests for utility.

A number of large prospective cohort studies have identified statistically significant risk factors for a range of sports injuries. For example, meta-analyses have shown that low strength is associated with an increased risk of hamstring injury.2 As van Mechelen and colleagues first described 30 years ago,3 gaining knowledge about injury risk factors is an important step toward developing effective prevention interventions. However, …
Cultured Coeliac Fibroblasts: a Suitable Source of Tissue Transglutaminase Antigen?
Authors: Z Hasyim, J Donlon, FM Stevens, RA Raja Ali
Journal: Endoscopy (2006)

Aims: To determine if cultured skin biopsies produce Tissue Transglutaminase (tTG) and study antigenic differences between coeliac and control tTG.
Abstract 232: A Genome-wide Association of Murine Echocardiographic Measures Implicates Muscle A-type Lamin-interacting Protein (MLIP) in Isoproterenol-induced Interventricular Septal Hypertrophy
Authors: Jessica J Wang, Christoph Rau, Shuxun Ren, Marie-Elodie Cattin, Patrick G Burgon, Yibin Wang, Aldons J Lusis
Journal: Circulation Research (2013)

Genome-wide association studies of heart failure in humans have yielded limited results, largely due to highly heterogeneous environmental and genetic backgrounds. The Hybrid Mouse Diversity Panel consists of inbred strains that are either fully sequenced or densely genotyped and as a whole displays significant natural variations. We assessed the hypothesis that precise environmental control, a well-defined genetic background, and a careful and uniform phenotyping scheme enable high-resolution mapping of cardiac remodeling in an isoproterenol-induced heart failure mouse model. Eight to ten-week old females from 105 inbred mouse strains (average N per strain = 6.7) were divided into control (average N per strain = 2.5) and treated (average N per strain =4.1) cohorts. Treated mice received 20 μg/g/day of isoproterenol through an abdominally implanted Alzet micropump for 3 weeks. All mice underwent echocardiography at baseline and at weekly time points. Phenotypic data were analyzed using the Efficient Mixed-Model Association (EMMA) algorithm to correct for population substructure. Our study showed that chronic isoproterenol administration resulted in marked inter-strain variations in echocardiographic measurements across the mouse panel. EMMA analysis of the data revealed many significant association peaks across echocardiographic measures. The most significant association signal is in the change of diastolic interventricular septal wall thickness between baseline and 1 week after isoproterenol treatment, a marker of early isoproterenol-induced left ventricular hypertrophy. The peak SNP rs13480288 (p-value of 4.0580e-09) and its surrounding SNPs (within correlation r2 &gt; 0.8) span across 3 genes. Of these, Mlip alone harbors a missence variant and a splice-site variant across our panel. Mlip, also known as muscle A-type lamin-interacting protein, is expressed abundantly in the heart and interacts directly with A-type lamins in the nuclear envelope. Mutations in A-type lamins have been shown to cause both hypertrophic and dilated cardiomyopathy. In conclusion, our study results provide strong evidence that genetic variations in Mlip contribute to differential responses in interverntricular septal hypertrophy to isoproterenol.
Regionalization and Outcomes of Lung Cancer Surgery in Ontario, Canada
Authors: Anna M. Bendzsak, Nancy N. Baxter, Gail E. Darling, Peter C. Austin, David R. Urbach
Journal: Journal of Clinical Oncology (2017)

Purpose Regionalization of complex surgery to high-volume hospitals has been advocated based on cross-sectional volume-outcome studies. In April 2007, the agency overseeing cancer care in Ontario, Canada, implemented a policy to regionalize lung cancer surgery at 14 designated hospitals, enforced by economic incentives and penalties. We studied the effects of implementation of this policy. Methods Using administrative health data, we used interrupted time series models to analyze the immediate and delayed effects of implementation of the policy on the distribution of lung cancer surgery among hospitals, surgical outcomes, and health services use. Results From 2004 to 2012, 16,641 patients underwent surgery for lung cancer. The proportion of operations performed in designated hospitals increased from 71% to 89% after the policy was implemented. Although operative mortality decreased from 4.1% to 2.9% (adjusted odds ratio, 0.68; 95% CI, 0.58 to 0.81; P < .001), the reduction was due to a preexisting declining trend in mortality. In contrast, in the years after implementation of the policy, length of hospital stay decreased more than expected from the baseline trend by 7% per year (95% CI, 5% to 9%; P < .001), and the distance traveled by all patients to the hospital for surgery increased by 4% per year (95% CI, 0% to 8%; P = .03), neither of which were explained by preexisting trends. Analyses limited to patients ≥ 70 years of age demonstrated a reduction in operative mortality (odds ratio, 0.80 per year after regionalization; 95% CI, 0.67 to 0.95; P = .01). Conclusion A policy to regionalize lung cancer surgery in Ontario led to increased centralization of surgery services but was not independently associated with improvements in operative mortality. Improvements in length of stay and in operative mortality among elderly patients suggest areas where regionalization may be beneficial.
Safety, efficacy, and pharmacokinetics of single-tablet elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in virologically suppressed, HIV-infected children: a single-arm, open-label trial
Authors: Eva Natukunda, Aditya H Gaur, Pope Kosalaraksa, Jagmohan Batra, Natella Rakhmanina, Danielle Porter, Yongwu Shao, Heather Zhang, Cheryl Pikora, Martin S Rhee
Journal: The Lancet Child & Adolescent Health (2017)
Beyond Belmont: Ensuring Respect for AI/AN Communities Through Tribal IRBs, Laws, and Policies
Authors: Sara Chandros Hull, David R. Wilson (Diné)
Journal: The American Journal of Bioethics (2017)

We concur with Friesen and colleagues (2017) that it is timely to reflect on the history of the Belmont Report and its role in the development of research regulations, especially its failure to acc...
Treatment patterns and clinical outcomes in patients with metastatic pancreatic cancer treated with first-line nab-paclitaxel plus gemcitabine: Analysis of US electronic health records from the Flatiron Health Database
Authors: Dawn Flick Elizabeth, Jack Shiansong Li, Gilbert Jirau-Lucca, Michael Ondovik, Melissa Nifenecker, Susan Fish, Helen Liu, Jian Hua Huang, Arlene Swern, Chrystal Louis
Journal: Annals of Oncology (2017)
Funnel-shaped retrieval device for wrapping large colorectal resection specimens
Authors: Nobuya Kobayashi, Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Tatsuo Yachida, Tsutomu Masaki
Journal: Endoscopy (2017)

Endoscopic submucosal dissection (ESD) has facilitated en bloc resection of large colorectal tumors [1]. The retrieval of a moderately sized specimen after ESD is common with use of a net forceps [2]. It is difficult however to retrieve a large colorectal specimen without any damage because of the typical anatomy of the anal canal with its narrow lumen, which sometimes results in the failure of accurate pathological evaluation. Although several retrieval methods have been reported recently, they seem to be insufficient in terms of wrapping the whole of a large specimen [3] [4]. Here we introduce a novel procedure that is reliable for the retrieval of a large colorectal specimen.
Marked Differences in the Genomic Landscape of Pediatric Compared to Adult Acute Myeloid Leukemia: A Report from the Children's Oncology Group and NCI/COG Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative
Authors: Jason E Farrar, Hamid Bolouri, Rhonda E. Ries, Timothy Junius Triche, Emilia L. Lim, Todd A. Alonzo, Yussanne Ma, Richard Moore, Andrew J. Mungall, Marco A. Marra, Jaime Guidry Auvil, Tanja M. Davidsen, Patee Gesuwan, Leandro C. Hermida, E. Anders Kolb, Alan S. Gamis, Malcolm A. Smith, Daniela S. Gerhard, Soheil Meshinchi
Journal: Blood (2016)
Invasive dermatophyte infection with <i>Trichophyton interdigitale</i> is associated with prurigo-induced pseudoperforation and a signal transducer and activator of transcription 3 mutation
Authors: J.K. Simpson, P. Fröbel, S.L. Seneviratne, M. Brown, D.M. Lowe, B. Grimbacher, M. Fliegauf, L. Fearfield
Journal: British Journal of Dermatology (2017)

Invasive dermatophyte infection, with extension beyond the dermis, in immunocompetent hosts is exceptionally rare. Dermatophytes are keratinophilic and are usually confined to the stratum corneum, hair and nails. Susceptibility to dermatophyte infections is incompletely understood, but inherited mutations in key signalling pathways of the innate immune system have been identified. We report the first case of an invasive dermatophyte infection associated with abrupt onset of a prurigo‐induced pseudoperforation and a loss‐of‐function mutation in signal transducer and activator of transcription 3 (STAT3).
Diabetes in sub-Saharan Africa: from clinical care to health policy
Authors: Rifat Atun, Justine I Davies, Edwin A M Gale, Till Bärnighausen, David Beran, Andre Pascal Kengne, Naomi S Levitt, Florence W Mangugu, Moffat J Nyirenda, Graham D Ogle, Kaushik Ramaiya, Nelson K Sewankambo, Eugene Sobngwi, Solomon Tesfaye, John S Yudkin, Sanjay Basu, Christian Bommer, Esther Heesemann, Jennifer Manne-Goehler, Iryna Postolovska, Vera Sagalova, Sebastian Vollmer, Zulfiqarali G Abbas, Benjamin Ammon, Mulugeta Terekegn Angamo, Akhila Annamreddi, Ananya Awasthi, Stéphane Besançon, Sudhamayi Bhadriraju, Agnes Binagwaho, Philip I Burgess, Matthew J Burton, Jeanne Chai, Felix P Chilunga, Portia Chipendo, Anna Conn, Dipesalema R Joel, Arielle W Eagan, Crispin Gishoma, Julius Ho, Simcha Jong, Sujay S Kakarmath, Yasmin Khan, Ramu Kharel, Michael A Kyle, Seitetz C Lee, Amos Lichtman, Carl P Malm, Maïmouna N Mbaye, Marie A Muhimpundu, Beatrice M Mwagomba, Kibachio Joseph Mwangi, Mohit Nair, Simon P Niyonsenga, Benson Njuguna, Obiageli L O Okafor, Oluwakemi Okunade, Paul H Park, Sonak D Pastakia, Chelsea Pekny, Ahmed Reja, Charles N Rotimi, Samuel Rwunganira, David Sando, Gabriela Sarriera, Anshuman Sharma, Assa Sidibe, Elias S Siraj, Azhra S Syed, Kristien Van Acker, Mahmoud Werfalli
Journal: The Lancet Diabetes & Endocrinology (2017)
Occurrence of Antibiotic Residues in Differentially Treated Wastewater and in Reclaimed Water Utilized in Spray Irrigation
Authors: Prachi Kulkarni, Nathanael D. Olson, Greg Raspanti, Rachel F. Rosenberg Goldstein, Shawn G. Gibbs, Amir Sapkota, Amy Sapkota
Journal: Environmental Health Perspectives (2017)
AGREE II assessments of recent acne treatment guidelines: how well do they reveal trustworthiness as defined by the U.S. Institute of Medicine criteria?
Authors: E.A. Eady, A.M. Layton, J. Sprakel, B.W.M. Arents, Z. Fedorowicz, E.J. van Zuuren
Journal: British Journal of Dermatology (2017)

Up‐to‐date, trustworthy guidelines are a widely relied upon means of promoting excellent patient care.
Hepatobiliary and Thromboembolic Events during Long-Term E.X.T.E.N.Ded Treatment with Eltrombopag in Adult Patients with Chronic Immune Thrombocytopenia (ITP)
Authors: Mansoor N. Saleh, James B Bussel, Raymond SM Wong, Balkis Meddeb, Abdulgabar Salama, Ali El-Ali, Erhard Quebe-Fehling, Abderrahim Khelif
Journal: Blood (2016)
Liver Biopsy in Patients with Chronic Lymphocytic Leukemia: Indications and Pathological Findings
Authors: Paul J. Hampel, Rebecca L King, Curtis A. Hanson, Douglas Simonetto, Kari G. Chaffee, Timothy G. Call, Wei Ding, Saad S Kenderian, Susan L. Slager, Neil E. Kay, Tait D. Shanafelt, Sameer A. Parikh
Journal: Blood (2016)
The Variation in Secretory Function of Different Regions of the Human Colon
Authors: A Patel, DL Bovell, AD Corbett, RJ Holdsworth
Journal: Endoscopy (2006)

Introduction: The colonic epithelium has both secretory and absorptive functions and much work has been carried out on animals such as rat and guinea pig, or on colonic cell lines. Currently we are researching the secretory properties of human colonic epithelium, utilising intact fresh mucosal sheets in an Ussing chamber.
Dynamic contrast enhanced MRI (DCE-MRI) for assessment of effects of anti-angiogenic therapy: Comparison of the transfer constant (Ktrans) to blood flow and permeability derived by a distributed parameter model
Authors: Choon Hua Thng, Tong San Koh, Septian Hartono, Helmut Rumpel, James Khoo, Albert Low, Ai Bee Ong, Norita Sukri, Bee Choo Tai, Ross Soo, Rod Humerickhouse, Boon Cher Goh
Journal: Clinical Cancer Research (2007)

A41  Background:  Transfer constant (Ktrans) and IAUC60 normalized with arterial input function are commonly used dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters. The distributed parameter (DP) model is a DCE-MRI model that enables derivation of blood flow and capillary permeability-surface area product (PS). We aim to study the DP model as an alternative method of angiogenesis assessment and correlate the above parameters to drug exposure and patient outcome in a Phase I anti-angiogenic trial.   Methods:  Twenty evaluable patients from an on-going phase I trial (ABT-869) with 3 dose escalations formed the study population. Pharmacokinetic study was performed on Day 1 and the area under the concentration time curve extrapolated to infinity (AUCinfinity) was used as an indicator of drug exposure. All patients underwent DCE-MRI at baseline, Day 3 and Day 15 with temporal resolution of 4 seconds. Gadolinium concentrations were estimated using dual flip angle method. Ktrans, normalized IAUC60, permeability-surface area product derived from DP model (DP-PS), and blood flow derived from DP model, were calculated. Patients demonstrating progressive disease in first 2 evaluations scans (cycle 2 or 4) based on RECIST criteria were considered progressors and all other patients, non-progressors. Receiver operating curve (ROC) analysis was performed. Correlation with AUCinfinity was analyzed.   Results:  1. There is good correlation between DP-PS and drug exposure measured by AUCinfinity (Spearman’s coefficient -0.557, p = 0.0108). Although stronger correlation is found with normalized IAUC60 (Spearman’s coefficient -0.678, p = 0.001), the difference is not significant. (p = 0.5476). There is no correlation for Ktrans (Spearman’s coefficient -0.128, p = 0.591).  2. ROC analysis for predicting progressors versus non-progressors showed a higher ROC area for DP-PS compared to Ktrans (0.868 versus 0.429, p
Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study
Authors: Xu Wang, Fengxiu Ouyang, Liping Feng, Xia Wang, Zhiwei Liu, Jun Zhang
Journal: Environmental Health Perspectives (2017)

Background: Triclosan (TCS) is a synthetic antibacterial chemical widely used in personal care products. TCS exposure has been associated with decreased thyroid hormone levels in animals, but human studies are scarce and controversial. Objective: We evaluated the association between maternal TCS exposure and thyroid hormone levels of mothers and newborns. Methods: TCS was measured by high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS) in urine samples collected during gestational weeks 38.8±1.1 from 398 pregnant women in a prospective birth cohort enrolled in 2012–2013 in Shanghai, China. Maternal serum levels of free thyroxine (FT4), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibody (TPOAb) were obtained from medical records. Cord blood levels of free triiodothyronine (FT3), FT4, TSH, and TPOAb were measured. Multiple linear and logistic regression models were used to examine the relationship between maternal urinary TCS and thyroid hormone levels. Results: TCS was detectable (≥0.1 ng/mL) in 98.24% of maternal urine samples with tertile of urinary TCS levels: low (<0.1–2.75μg/g.Cr), medium (2.75–9.78μg/g.Cr), and high (9.78–427.38μg/g.Cr). With adjustment for potential confounders, cord blood log(FT3)pmol/L concentration was 0.11 lower in newborns of mothers with medium and high urinary TCS levels compared with those with low levels. At third trimester, the high TCS concentration was associated with 0.03 [95% confidence interval (CI) −0.08, −0.02] lower maternal serum log(FT4)pmol/L, whereas the medium TCS concentration was associated with 0.15 (95% CI: −0.28, −0.03) lower serum log(TSH)mIU/L with adjustment for covariates. Conclusions: Our results suggest significant inverse associations between maternal urinary TCS and cord blood FT3 as well as maternal blood FT4 concentrations at third trimester. https://doi.org/10.1289/EHP500
Long-term health status and trajectories of seriously injured patients: A population-based longitudinal study
Authors: Belinda J. Gabbe, Pam M. Simpson, Peter A. Cameron, Jennie Ponsford, Ronan A. Lyons, Alex Collie, Mark Fitzgerald, Rodney Judson, Warwick J. Teague, Sandra Braaf, Andrew Nunn, Shanthi Ameratunga, James E. Harrison
Journal: PLoS Medicine (2017)

Improved understanding of the quality of survival of patients is crucial in evaluating trauma care, understanding recovery patterns and timeframes, and informing healthcare, social, and disability service provision. We aimed to describe the longer-term health status of seriously injured patients, identify predictors of outcome, and establish recovery trajectories by population characteristics.
Scotland plans to move to opt-out system for organ donation
Authors: Bryan Christie
Journal: BMJ (2017)

Scotland will introduce legislation aimed at increasing organ donation by moving to a system of “soft opt-out” that will allow organs to be used in transplants without express permission.

This is a reversal of the current situation where people have to opt in by joining the donor card scheme. It follows a public consultation in which more than 80% of respondents supported the …