tbuckley/cabot-search huggingface dataset:
Patients With Lung Cancer Need Love Too
Authors: Diana Fishbein
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
脆弱なアテローム性動脈硬化症プラークを標的とする金ナノ粒子ベースSPECT/CTイメージングプローブ【Powered by NICT】
Authors: Li Xiao, Wang Cong, Tan Hui, Cheng Leilei, Liu Guobing, Yang Yi, Zhao Yanzhao, Zhang Yiqiu, Li Yanli, Zhang Chunfu, Xiu Yan, Cheng Dengfeng, Shi Hongcheng
Journal: Biomaterials (2016)
Presenting to Primary Stroke Centers or Comprehensive Stroke Centers for Thrombolysis—Reply
Authors: Gaspard Gerschenfeld, Sonia Alamowitch
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway
Authors: Lin Jin, Trung Vu, Guandou Yuan, Pran K. Datta
Journal: Cancer Research (2017)

Abstract NOTCH signaling exerts essential roles in normal and malignant intestinal physiology and the homeostasis of cancer stem-like cells (CSC), but the basis for this latter role remains obscure. The signaling scaffold protein STRAP is upregulated in several cancers, where it promotes tumorigenicity and metastasis. Here we report a novel oncogenic function for STRAP in maintaining CSC subpopulations in a heterogeneous mixture by antagonizing formation of the chromatin modifier PRC2 and by epigenetically activating NOTCH signals in human colorectal cancer. Silencing STRAP sensitized colorectal cancer cells to chemotherapeutic drugs in vitro and in vivo. STRAP depletion also contributed to a reduced stem-like phenotype of colorectal cancer cells, as indicated by reduced expression of the CSC signature and NOTCH signaling regulators in vitro and by diminished tumorigenesis in vivo. Genes encoding some upstream activators of NOTCH were highly enriched for H3K27me3, which forms repressive chromatin domains upon STRAP silencing. Mechanistically, STRAP competitively disrupted association of the PRC2 subunits EZH2 and SUZ12, thereby inhibiting PRC2 assembly. Restoring the NOTCH pathway by lentiviral expression of NICD1 or HES1 in STRAP-depleted tumor cells reversed the CSC phenotype. In 90 colorectal cancer clinical specimens, a significant positive correlation was documented between the expression of STRAP and HES1. Overall, our findings illuminated a novel STRAP–NOTCH1–HES1 molecular axis as a CSC regulator in colorectal cancer, with potential implications to improve treatment of this disease. Cancer Res; 77(20); 5464–78. ©2017 AACR.
Exercise and the right ventricle: a potential Achilles’ heel
Authors: Andre La Gerche, Dhrubo J. Rakhit, Guido Claessen
Journal: Cardiovascular Research (2017)

Exercise is associated with unequivocal health benefits and results in many structural and functional changes of the myocardium that enhance performance and prevent heart failure. However, intense exercise also presents a significant hemodynamic challenge in which the right-sided heart chambers are exposed to a disproportionate increase in afterload and wall stress that can manifest as myocardial fatigue or even damage if intense exercise is sustained for prolonged periods. This review focuses on the physiological factors that result in a disproportionate load on the right ventricle during exercise and the long-term consequences. The changes in cardiac structure and function that define 'athlete's heart' disproportionately affect the right-sided heart chambers and this can raise important diagnostic overlap with some cardiac pathologies, particularly some inherited cardiomyopathies. The interaction between exercise and arrhythmogenic right ventricular cardiomyopathy (ARVC) will be highlighted as an important example of how hemodynamic stressors can combine with deficiencies in cardiac structural elements to cause cardiac dysfunction predisposing to arrhythmias. The extent to which extreme exercise can cause adverse remodelling in the absence of a genetic predisposition remains controversial. In the athlete with profound changes in heart structure, it can be extremely challenging to determine whether common symptoms such as palpitations may be a marker of more sinister arrhythmias. This review discusses some of the techniques that have recently been proposed to identify pathology in these circumstances. Finally, we will discuss recent evidence defining the role of exercise restriction as a therapeutic intervention in individuals predisposed to arrhythmogenic cardiomyopathy.
血管標的ドラッグデリバリーにおける変形可能な粒子の探索:柔らかいは時々優れている【Powered by NICT】
Authors: B Fish Margaret, A Fromen Catherine, Lopez-Cazares Genesis, W Golinski Alexander, F Scott Timothy, Adili Reheman, Holinstat Michael, Eniola-Adefeso Omolola
Journal: Biomaterials (2017)
Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial
Authors: Kuang-Chih Hsiao, Anne-Louise Ponsonby, Christine Axelrad, Sigrid Pitkin, Mimi L K Tang, Wesley Burks, Susan Donath, Francesca Orsini, Dean Tey, Marnie Robinson, Ee Lyn Su
Journal: The Lancet Child & Adolescent Health (2017)
Clonal evolution is a prognostic factor for the clinical progression of monoclonal B-cell lymphocytosis
Authors: I V Kostopoulos, G Paterakis, D Pavlidis, E Kastritis, E Terpos, O E Tsitsilonis, S I Papadhimitriou
Journal: Blood Cancer Journal (2017)

Monoclonal B-cell lymphocytosis (MBL) has attracted intensive research as the prelude of chronic lymphoproliferative disorders, mainly chronic lymphocytic leukemia (CLL).1 According to current criteria, MBL is a preclinical condition characterized by monoclonal B-cell expansions at small concentrations (<5 × 109 cells/l) in the peripheral blood of otherwise healthy individuals.2, 3 It is now obvious that MBL is a highly heterogeneous entity regarding the immunophenotypic characteristics and the B-cell clone burden.4, 5, 6 In immunophenotypic terms, MBL is distinguished into three main categories: (i) CLL-like (CD5+CD20dimCD23+sIglow) accounting for 70–75% of all cases; (ii) atypical (CD5+CD20bright/+), mainly CD23dim/−; and (iii) CD5neg MBL.2, 3 Based on the number of monoclonal B-cells, MBL is divided into low and high-count, each with a clearly different clinical course.5, 6, 7 Low-count MBL is a non-progressive entity with a normal absolute B-cell count, whereas high-count or ‘clinical’ MBL (cMBL) is characterized by absolute lymphocytosis and progresses to CLL at a rate of ~1–2% per year.8, 9
Diagnosis and Management of Asymptomatic Primary Hyperparathyroidism: Consensus Development Conference Statement
Journal: Annals of Internal Medicine (1991)

Endocrinologists, surgeons, radiologists, epidemiologists, and primary health care providers convened to address both indications for surgery in asymptomatic patients with hyperparathyroidism as well as how patients who do not have surgery should be monitored and managed to minimize the risk for complications. The National Institutes of Health Consensus Development Conference Panel concluded that a diagnosis of hyperparathyroidism is established by showing persistent hypercalcemia and an elevated serum parathyroid hormone concentration; that the current and acceptable treatment for hyperparathyroidism is surgery; that the diagnosis of hyperparathyroidism in an asymptomatic patient does not in all cases mandate referral for surgery; that conscientious surveillance may be justified in patients whose calcium levels are only mildly elevated and whose renal and bone status are close to normal; and that preoperative localization in patients without previous neck operation is rarely indicated and has not proved to be cost effective.
Concerns about NHS treatment of older people are often unreported, survey finds
Authors: Gareth Iacobucci
Journal: BMJ (2017)

Concerns about the treatment of older people by the NHS are often unreported, research has suggested.1

A survey by the social networking website Gransnet and the parliamentary and health service ombudsman found that only 58% of people who were concerned about the treatment of their older relative had complained to the NHS. The ombudsman said that the findings were “deeply concerning” and said it was vital that older people and their families felt able to complain about poor care or treatment in hospital.

The poll sought views from over 600 Gransnet members who had had an older relative spend …
Imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection from Oman to Thailand, June 2015
Authors: Tanarak Plipat, Rome Buathong, Supaporn Wacharapluesadee, Potjaman Siriarayapon, Chakrarat Pittayawonganon, Chariya Sangsajja, Thongchai Kaewpom, Sininat Petcharat, Teerada Ponpinit, Jaruphan Jumpasri, Yutthana Joyjinda, Apaporn Rodpan, Siriporn Ghai, Akanitt Jittmittraphap, Sarawut Khongwichit, Duncan R Smith, Victor M Corman, Christian Drosten, Thiravat Hemachudha
Journal: Eurosurveillance (2017)

Thailand reported the first Middle East respiratory syndrome (MERS) case on 18 June 2015 (day 4) in an Omani patient with heart condition who was diagnosed with pneumonia on hospital admission on 15 June 2015 (day 1). Two false negative RT-PCR on upper respiratory tract samples on days 2 and 3 led to a 48-hour diagnosis delay and a decision to transfer the patient out of the negative pressure unit (NPU). Subsequent examination of sputum later on day 3 confirmed MERS coronavirus (MERS-CoV) infection. The patient was immediately moved back into the NPU and then transferred to Bamrasnaradura Infectious Disease Institute. Over 170 contacts were traced; 48 were quarantined and 122 self-monitored for symptoms. High-risk close contacts exhibiting no symptoms, and whose laboratory testing on the 12th day after exposure was negative, were released on the 14th day. The Omani Ministry of Health (MOH) was immediately notified using the International Health Regulation (IHR) mechanism. Outbreak investigation was conducted in Oman, and was both published on the World Health Organization (WHO) intranet and shared with Thailand’s IHR focal point. The key to successful infection control, with no secondary transmission, were the collaborative efforts among hospitals, laboratories and MOHs of both countries.
The Role of Intrinsic Brain Functional Connectivity in Vulnerability and Resilience to Bipolar Disorder
Authors: Gaelle E. Doucet, Danielle S. Bassett, Nailin Yao, David C. Glahn, Sophia Frangou
Journal: American Journal of Psychiatry (2017)

Bipolar disorder is a heritable disorder characterized by mood dysregulation associated with brain functional dysconnectivity. Previous research has focused on the detection of risk- and disease-associated dysconnectivity in individuals with bipolar disorder and their first-degree relatives. The present study seeks to identify adaptive brain connectivity features associated with resilience, defined here as avoidance of illness or delayed illness onset in unaffected siblings of patients with bipolar disorder.Graph theoretical methods were used to examine global and regional brain network topology in head-motion-corrected resting-state functional MRI data acquired from 78 patients with bipolar disorder, 64 unaffected siblings, and 41 healthy volunteers.Global network properties were preserved in patients and their siblings while both groups showed reductions in the cohesiveness of the sensorimotor network. In the patient group, these sensorimotor network abnormalities were coupled with reduced integration of core default mode network regions in the ventromedial cortex and hippocampus. Conversely, integration of the default mode network was increased in the sibling group compared with both the patient group and the healthy volunteer group.The authors found that trait-related vulnerability to bipolar disorder was associated with reduced resting-state cohesiveness of the sensorimotor network in patients with bipolar disorder. However, integration of the default mode network emerged as a key feature differentiating disease expression and resilience between the patients and their siblings. This is indicative of the presence of neural mechanisms that may promote resilience, or at least delay illness onset.
Management of Post-Transplant Lymphoproliferative Disorders in the Real Life: The French Attitude Between 2010 and 2013
Authors: Inès Boussen, Caroline Algrin, Julien Rossignol, Eric Durot, Sarah Guenounou, Antoine Bonnet, Jeremy Delage, Emmanuel Gyan, Fontanet Bijou, Noel Milpied, Adrien Chauchet, Adrien Tempescul, Gandhi Damaj, Arnaud Jaccard, Jerome Cornillon, Norbert Ifrah, Veronique Leblond, Sylvain Choquet
Journal: Blood (2016)
原子価と密度物質合成糖重合体を用いた腫瘍関連炭水化物抗原に対する免疫応答に及ぼす免疫原構造の解読への影響【Powered by NICT】
Authors: Qin Qian, Yin Zhaojun, Wu Xuanjun, M Haas Karen, Huang Xuefei
Journal: Biomaterials (2016)
Targeting Inflammation in Coronary Artery Disease
Authors: Robert A. Harrington
Journal: New England Journal of Medicine (2017)

For more than 20 years, our understanding of the biology of atherosclerosis has incorporated the so-called inflammatory hypothesis.1,2 Inflammatory cells and signals drive the healing response to vascular injury, allowing the initiation and growth of atherosclerotic plaque. Inflammatory reactions probably increase plaque instability, possibly resulting in plaque rupture, fissuring, or erosion and setting up the substrate for the thrombotic response that causes myocardial damage or infarction. Yet, no strictly antiinflammatory drugs are used to treat patients with coronary artery disease. Effective cardiovascular drugs with antiinflammatory effects, such as aspirin and statins, predominantly exert therapeutic benefits by means of mechanisms other . . .
A score to predict and stratify risk of tuberculosis in adult contacts of tuberculosis index cases: a prospective derivation and external validation cohort study
Authors: Matthew J Saunders, Tom Wingfield, Marco A Tovar, Matthew R Baldwin, Sumona Datta, Karine Zevallos, Rosario Montoya, Teresa R Valencia, Jon S Friedland, Larry H Moulton, Robert H Gilman, Carlton A Evans
Journal: The Lancet Infectious Diseases (2017)

Contacts of tuberculosis index cases are at increased risk of developing tuberculosis. Screening, preventive therapy, and surveillance for tuberculosis are underused interventions in contacts, particularly adults. We developed a score to predict risk of tuberculosis in adult contacts of tuberculosis index cases.In 2002-06, we recruited contacts aged 15 years or older of index cases with pulmonary tuberculosis who lived in desert shanty towns in Ventanilla, Peru. We followed up contacts for tuberculosis until February, 2016. We used a Cox proportional hazards model to identify index case, contact, and household risk factors for tuberculosis from which to derive a score and classify contacts as low, medium, or high risk. We validated the score in an urban community recruited in Callao, Peru, in 2014-15.In the derivation cohort, we identified 2017 contacts of 715 index cases, and median follow-up was 10·7 years (IQR 9·5-11·8). 178 (9%) of 2017 contacts developed tuberculosis during 19 147 person-years of follow-up (incidence 0·93 per 100 person-years, 95% CI 0·80-1·08). Risk factors for tuberculosis were body-mass index, previous tuberculosis, age, sustained exposure to the index case, the index case being in a male patient, lower community household socioeconomic position, indoor air pollution, previous tuberculosis among household members, and living in a household with a low number of windows per room. The 10-year risks of tuberculosis in the low-risk, medium-risk, and high-risk groups were, respectively, 2·8% (95% CI 1·7-4·4), 6·2% (4·8-8·1), and 20·6% (17·3-24·4). The 535 (27%) contacts classified as high risk accounted for 60% of the tuberculosis identified during follow-up. The score predicted tuberculosis independently of tuberculin skin test and index-case drug sensitivity results. In the external validation cohort, 65 (3%) of 1910 contacts developed tuberculosis during 3771 person-years of follow-up (incidence 1·7 per 100 person-years, 95% CI 1·4-2·2). The 2·5-year risks of tuberculosis in the low-risk, medium-risk, and high-risk groups were, respectively, 1·4% (95% CI 0·7-2·8), 3·9% (2·5-5·9), and 8·6%· (5·9-12·6).Our externally validated risk score could predict and stratify 10-year risk of developing tuberculosis in adult contacts, and could be used to prioritise tuberculosis control interventions for people most likely to benefit.Wellcome Trust, Department for International Development Civil Society Challenge Fund, Joint Global Health Trials consortium, Bill & Melinda Gates Foundation, Imperial College National Institutes of Health Research Biomedical Research Centre, Foundation for Innovative New Diagnostics, Sir Halley Stewart Trust, WHO, TB REACH, and Innovation for Health and Development.
Lysosomal processing of progranulin
Authors: Xiaolai Zhou, Daniel H. Paushter, Tuancheng Feng, Lirong Sun, Thomas Reinheckel, Fenghua Hu
Journal: Molecular Neurodegeneration (2017)

Mutations resulting in progranulin (PGRN) haploinsufficiency cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. PGRN is localized to the lysosome and important for proper lysosome function. However, the metabolism of PGRN in the lysosome is still unclear.Here, we report that PGRN is processed into ~10 kDa peptides intracellularly in multiple cell types and tissues and this processing is dependent on lysosomal activities. PGRN endocytosed from the extracellular space is also processed in a similar manner. We further demonstrated that multiple cathepsins are involved in PGRN processing and cathepsin L cleaves PGRN in vitro.Our data support that PGRN is processed in the lysosome through the actions of cathepsins.
Baseline and On-Treatment Characteristics of Serum Tumor Markers in Stage IV Oncogene-Addicted Adenocarcinoma of the Lung
Authors: Sinead A. Noonan, Tejas Patil, Dexiang Gao, Gentry G. King, Jessica R. Thibault, Xian Lu, Paul A. Bunn, Robert C. Doebele, W. Thomas Purcell, Anna E. Barón, D. Ross Camidge
Journal: Journal of Thoracic Oncology (2017)
Improved Recovery of Erectile Function in Younger Men after Radical Prostatectomy: Does it Justify Immediate Surgery in Low-risk Patients?
Authors: Justin K. Lee, Daniel D. Sjoberg, Mariam Imnadze Miller, Andrew J. Vickers, John P. Mulhall, Behfar Ehdaie
Journal: European Urology (2017)

Although active surveillance is increasingly used for the management of low-risk prostate cancer, many eligible patients are still nonetheless subject to curative treatment. One argument for considering surgery rather than active surveillance is that the probability of postoperative recovery of erectile function is age dependent, that is, patients who delay surgery may lose the window of opportunity to recover erectile function after surgery.To model erectile function over a 10-yr period for immediate surgery versus active surveillance.Data from 1103 men who underwent radical prostatectomy at a tertiary referral center were used.Patients completed the International Index of Erectile Function (IIEF-6) pre- and postoperatively as a routine part of clinical care. Preoperative IIEF-6 scores were plotted against age to assess the natural rate of functional decline due to aging. Reported erectile scores in the 2-yr period following surgery were used to assess post-surgical recovery.Each year increase in patient age resulted in a 0.27 reduction in IIEF scores. In addition to IIEF reducing with increased age, the amount of erectile function that is recovered from presurgery to 12-mo postsurgery also decreases (-0.16 IIF points/yr, 95% confidence interval -0.27, -0.05, p=0.006). However, delayed radical prostatectomy increased the mean IIEF-6 score over a 10-yr period compared with immediate surgery (p=0.001), even under the assumption that all men placed on active surveillance are treated within 5 yr.Small differences in erectile function recovery in younger men are offset by a longer period of time living with decreased postoperative function. Better erectile recovery in younger men should not be a factor used to recommend immediate surgery in patients suitable for active surveillance, even if crossover to surgery is predicted within a short period of time.Younger men have better recovery of erectile function after surgery for prostate cancer. This has led to the suggestion that delaying surgery for low-risk disease may lead patients to miss a window of opportunity to recover erectile function postoperatively. We conducted a modeling study and found that predicted erectile recovery was far superior on delayed treatment because slightly better recovery in younger men is offset by a longer period of time living with poorer postoperative function in those choosing immediate surgery.