tbuckley/cabot-search huggingface dataset:
Diagnostic criteria for idiopathic pulmonary fibrosis – Authors’ reply
Authors: David A Lynch, Nicola Sverzellati, William D Travis, Thomas V Colby, Yoshikazu Inoue, Andrew G Nicholson, Suhail Raoof, Luca Richeldi, Christopher J Ryerson, Jay H Ryu
Journal: The Lancet Respiratory Medicine (2018)
Retreat From Human Rights and Adverse Consequences for Health
Authors: Diederik Lohman
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Grade II Acute Gvhd Improves Progression-Free Survival after Myeloablative HLA-Matched Bone Marrow Transplant with Posttransplantation Cyclophosphamide
Authors: Shannon R. McCurdy, Christopher G. Kanakry, Hua-Ling Tsai, Javier Bolaños-Meade, Ephraim J. Fuchs, Gary Rosner, Richard J. Jones, Leo Luznik
Journal: Blood (2017)
The Impact of the Administration Schedule and Mutational Profile on Outcomes of Patients with Relapsed and Refractory Acute Myeloid Leukemia Treated with Hypomethylating Agents: A Large, International, Multi-Center Analysis
Authors: Maximilian Stahl, Michelle Deveaux, Pau Montesinos, Raphael Itzykson, Ellen K Ritchie, Mikkael A. Sekeres, Nikolai A. Podoltsev, Amir T. Fathi, Rami S. Komrokji, Vijaya R. Bhatt, Aref Al-Kali, Thomas Cluzeau, Valeria Santini, Andrew M. Brunner, Gail J. Roboz, Pierre Fenaux, Mark R. Litzow, Sera Perreault, Tae Kon Kim, Thomas Prebet, Norbert Vey, Vivek Verma, Ulrich Germing, Juan Bergua, Josefina Serrano, Steven D. Gore, Amer M. Zeidan
Journal: Blood (2017)
Immune Checkpoint Profiling of TP53 Mutant and Wild-Type Myeloid Malignancies: TP53 Mutations Direct Immune Tolerance Via an Immunosuppressive Phenotype
Authors: David A Sallman, McLemore Amy, Rami S. Komrokji, Kathy McGraw, Susan M. Geyer, Erika Eksioglu, Najla Al Ali, Jeffrey E. Lancet, Sheng Wei, Eric Padron, Alan F. List
Journal: Blood (2017)
Impact of <i>EML4-ALK</i> Variant on Resistance Mechanisms and Clinical Outcomes in <i>ALK</i>-Positive Lung Cancer
Authors: Jessica J. Lin, Viola W. Zhu, Satoshi Yoda, Beow Y. Yeap, Alexa B. Schrock, Ibiayi Dagogo-Jack, Nicholas A. Jessop, Ginger Y. Jiang, Long P. Le, Kyle Gowen, Philip J. Stephens, Jeffrey S. Ross, Siraj M. Ali, Vincent A. Miller, Melissa L. Johnson, Christine M. Lovly, Aaron N. Hata, Justin F. Gainor, Anthony J. Iafrate, Alice T. Shaw, Sai-Hong Ignatius Ou
Journal: Journal of Clinical Oncology (2018)

Purpose Advanced anaplastic lymphoma kinase ( ALK) fusion-positive non-small-cell lung cancers (NSCLCs) are effectively treated with ALK tyrosine kinase inhibitors (TKIs). However, clinical outcomes in these patients vary, and the benefit of TKIs is limited as a result of acquired resistance. Emerging data suggest that the ALK fusion variant may affect clinical outcome, but the molecular basis for this association is unknown. Patients and Methods We identified 129 patients with ALK-positive NSCLC with known ALK variants. ALK resistance mutations and clinical outcomes on ALK TKIs were retrospectively evaluated according to ALK variant. A Foundation Medicine data set of 577 patients with ALK-positive NSCLC was also examined. Results The most frequent ALK variants were EML4-ALK variant 1 in 55 patients (43%) and variant 3 in 51 patients (40%). We analyzed 77 tumor biopsy specimens from patients with variants 1 and 3 who had progressed on an ALK TKI. ALK resistance mutations were significantly more common in variant 3 than in variant 1 (57% v 30%; P = .023). In particular, ALK G1202R was more common in variant 3 than in variant 1 (32% v 0%; P < .001). Analysis of the Foundation Medicine database revealed similar associations of variant 3 with ALK resistance mutation and with G1202R ( P = .010 and .015, respectively). Among patients treated with the third-generation ALK TKI lorlatinib, variant 3 was associated with a significantly longer progression-free survival than variant 1 (hazard ratio, 0.31; 95% CI, 0.12 to 0.79; P = .011). Conclusion Specific ALK variants may be associated with the development of ALK resistance mutations, particularly G1202R, and provide a molecular link between variant and clinical outcome. ALK variant thus represents a potentially important factor in the selection of next-generation ALK inhibitors.
Single Nucleotide Polymorphisms in CD40L Predict Endothelial Complications and Mortality After Allogeneic Stem-Cell Transplantation
Authors: Sivaramakrishna P. Rachakonda, Hao Dai, Olaf Penack, Olga Blau, Igor Wolfgang Blau, Aleksandar Radujkovic, Carsten Müller-Tidow, Rajiv Kumar, Peter Dreger, Thomas Luft
Journal: Journal of Clinical Oncology (2018)

Purpose Endothelial vulnerability is a potential risk factor for complications after allogeneic stem-cell transplantation (alloSCT). The CD40/CD40 ligand (CD40L) axis contributes to inflammatory diseases and is upregulated in endothelial cells upon activation, suggesting a role in alloSCT biology. Here, we studied single nucleotide polymorphisms (SNPs) in the CD40L gene in recipients of alloSCT. Patients and Methods Three CD40L SNPs (rs3092920, rs3092952, rs3092936) were analyzed for association with transplant-associated thrombotic microangiopathy, overall nonrelapse mortality (NRM), and NRM after acute graft-versus-host disease in 294 recipients of alloSCT without statin-based endothelial prophylaxis (SEP). The significant genotype was then put into perspective with established thrombomodulin ( THBD) gene polymorphisms. Findings were validated in an independent cohort without SEP and in an additional 344 patients who received SEP. Results The rs3092936 CC/CT genotype was associated with an increased risk of transplant-associated thrombotic microangiopathy ( P = .001), overall NRM ( P = .03), and NRM after acute graft-versus-host disease ( P = .01). The rs3092936 CC/CT genotype was largely mutually exclusive of high-risk THBD SNPs. Both CD40L and THBD SNPs predicted adverse overall survival (OS) and overall NRM to a similar extent in training cohort (OS, P = .04; NRM, P < .001) and validation cohort (OS, P = .01; NRM, P = .001) without SEP. In contrast, SEP completely abolished the influence of the high-risk CD40L and THBD SNPs ( P = .40). Conclusion An increased risk of endothelial complications can be predicted before alloSCT by genetic markers in the recipient's genome. The normalization of mortality risks in patients treated with SEP suggests a way of overcoming the negative effect of high-risk genotypes and warrants further clinical validation.
The Heart-Brain Team—Towards Optimal Team-Based Coordinated Care
Authors: Mohamad Alkhouli, Jonathan Graff-Radford, David R. Holmes
Journal: JAMA Cardiology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Validation of the Medical Research Council (MRC) and the Leukemia Research Foundation (LRF) Score for Hypomethylating Agents (HMAs) Use in Patients with Relapsed and Refractory Acute Myeloid Leukemia (RR-AML)
Authors: Michelle Deveaux, Maximilian Stahl, Pau Montesinos, Raphael Itzykson, Ellen K Ritchie, Mikkael A. Sekeres, John Barnard, Nikolai A. Podoltsev, Andrew M. Brunner, Rami S. Komrokji, Vijaya R. Bhatt, Aref Al-Kali, Thomas Cluzeau, Valeria Santini, Gail J. Roboz, Pierre Fenaux, Mark R. Litzow, Amir T. Fathi, Sera Perreault, Tae Kon Kim, Thomas Prebet, Norbert Vey, Vivek Verma, Ulrich Germing, Juan Bergua, Josefina Serrano, Steven D. Gore, Amer M. Zeidan
Journal: Blood (2017)
Right Ventricular Myofilament Functional Differences in Humans With Systemic Sclerosis–Associated Versus Idiopathic Pulmonary Arterial Hypertension
Authors: Steven Hsu, Kristen M. Kokkonen-Simon, Jonathan A. Kirk, Todd M. Kolb, Rachel L. Damico, Stephen C. Mathai, Monica Mukherjee, Ami A. Shah, Fredrick M. Wigley, Kenneth B. Margulies, Paul M. Hassoun, Marc K. Halushka, Ryan J. Tedford, David A. Kass
Journal: Circulation (2018)

Background: Patients with systemic sclerosis (SSc)–associated pulmonary arterial hypertension (PAH) have a far worse prognosis than those with idiopathic PAH (IPAH). In the intact heart, SSc-PAH exhibits depressed rest and reserve right ventricular (RV) contractility compared with IPAH. We tested whether this disparity involves underlying differences in myofilament function. Methods: Cardiac myocytes were isolated from RV septal endomyocardial biopsies from patients with SSc-PAH, IPAH, or SSc with exertional dyspnea but no resting PAH (SSc-d); control RV septal tissue was obtained from nondiseased donor hearts (6–7 per group). Isolated myocyte passive length-tension and developed tension-calcium relationships were determined and correlated with in vivo RV function and reserve. RV septal fibrosis was also examined. Results: Myocyte passive stiffness from length-tension relations was similarly increased in IPAH and SSc-PAH compared with control, although SSc-PAH biopsies had more interstitial fibrosis. More striking disparities were found between active force-calcium relations. Compared with controls, maximal calcium-activated force (F max ) was 28% higher in IPAH but 37% lower in SSc-PAH. F max in SSc-d was intermediate between control and SSc-PAH. The calcium concentration required for half-maximal force (EC 50 ) was similar between control, IPAH, and SSc-d but lower in SSc-PAH. This disparity disappeared in myocytes incubated with the active catalytic subunit of protein kinase A. Myocyte F max directly correlated with in vivo RV contractility assessed by end-systolic elastance ( R 2 =0.46, P =0.002) and change in end-systolic elastance with exercise ( R 2 =0.49, P =0.008) and was inversely related with exercise-induced chamber dilation ( R 2 =0.63, P &lt;0.002), which also was a marker of depressed contractile reserve. Conclusions: A primary defect in human SSc-PAH resides in depressed sarcomere function, whereas this is enhanced in IPAH. These disparities correlate with in vivo RV contractility and contractile reserve and are consistent with worse clinical outcomes in SSc-PAH. The existence of sarcomere disease before the development of resting PAH in patients with SSc-d suggests that earlier identification and intervention may prove useful.
Abstract 20026: Physical Activity and Appetite in Patients With Stable Heart Failure - A Cross Sectional Study
Authors: Christina Andreae, Kristofer Arestedt, Lorraine S. Evangelista, Anna Stromberg
Journal: Circulation (2017)

Introduction: Physical activity plays a key role in heart failure (HF) management and potentially reduces symptoms and hospitalizations. Yet, a large number of patients with HF are physically inact...
Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues
Authors: Aadil A. Khan, James T. Paget, Martin McLaughlin, Joan N. Kyula, Michelle J. Wilkinson, Timothy Pencavel, David Mansfield, Victoria Roulstone, Rohit Seth, Martin Halle, Navita Somaiah, Jessica K. R. Boult, Simon P. Robinson, Hardev S. Pandha, Richard G. Vile, Alan A. Melcher, Paul A. Harris, Kevin J. Harrington
Journal: Science Translational Medicine (2018)

Vascular protection using gene therapy can reduce the late toxicities of radiotherapy.
Enasidenib-Induced Differentiation Syndrome in <i>IDH2</i>-Mutant Acute Myeloid Leukemia
Authors: Shyam A. Patel
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Endoscopic mucosal resection of rectal squamous cell papilloma
Authors: Mohamed Alkady, Shaimaa Elkholy
Journal: Endoscopy (2018)

A 22-year-old male patient presented with a 3-month history of persistent, colicky, lower abdominal pain. He was referred for colonoscopy. Total colonoscopy showed multiple small-to-medium sized pale pink, nonulcerated, polypoid lesions in the distal part of the rectum, occupying most of the circumference ([Fig. 1]).
Role of Complex Epigenetic Switching in Tumor Necrosis Factor-α Upregulation in the Prefrontal Cortex of Suicide Subjects
Authors: Qingzhong Wang, Bhaskar Roy, Gustavo Turecki, Richard C. Shelton, Yogesh Dwivedi
Journal: American Journal of Psychiatry (2018)

Objective: Proinflammatory cytokines have recently received considerable attention for their role in suicidal behavior; however, how the expression of cytokine genes is regulated is not clearly known. The authors examined underlying mechanisms of critical cytokine gene tumor necrosis factor–alpha (TNF-α) dysregulation in the brains of individuals who died by suicide. Method: TNF-α expression was examined in the dorsolateral prefrontal cortex of the postmortem brains of persons with and without major depressive disorder who died by suicide and of persons with major depressive disorder who died of causes other than suicide. The role of putative microRNAs targeting TNF-α and RNA-binding protein Hu antigen R (HuR) was tested with in vitro and in vivo approaches and by examining expression of transactivation response RNA binding protein (TRBP). Genetic influence on TNF-α expression was determined by expression quantitative trait loci analysis and by genotyping three single-nucleotide polymorphisms in the promoter region of the TNF-α gene. Promoter methylation of TNF-α was determined by using methylated DNA immunoprecipitation assay. Expression of miR-19a-3p and TNF-α was also determined in the peripheral blood mononuclear cells of 12 healthy control subjects and 12 currently depressed patients with severe suicidal ideation. Results: TNF-α expression was significantly higher in the dorsolateral prefrontal cortex of individuals who died by suicide, regardless of psychiatric diagnosis. Its expression level was also increased in individuals with major depressive disorder who died by causes other than suicide. On the other hand, expression of miR-19a-3p was upregulated specifically in individuals who died by suicide. In a preliminary observation, similar upregulation of TNF-α and miR-19a-3p was observed in the peripheral blood mononuclear cells of depressed patients with suicidal ideation. Despite its ability to directly target TNF-α in vitro, miR-19a-3p showed no interaction with TNF-α in the dorsolateral prefrontal cortex. HuR potentially stabilized TNF-α transcript, presumably by sequestering its 3′ untranslated region from miR-19a-3p–mediated inhibition. Furthermore, decreased TRBP expression supported abnormality in the interaction between miR-19a-3p and TNF-α. Additionally, TNF-α transcriptional upregulation was associated with promoter hypomethylation, whereas no genetic influence on altered TNF-α or miR-19a-3p expression was observed in individuals who died by suicide. Conclusions: The data in this study provide mechanistic insights into the dysregulation of the TNF-α gene in the brains of individuals who died by suicide, which could potentially be involved in suicidal behavior.
NADPH Oxidases Inhibitors Induce Oxidative Stress and Apoptosis in Acute Myeloid Leukemia Cells
Authors: Hassan Dakik, Jerome Bourgeais, Ali Nehme, Frederic Picou, Noemie Ravalet, Farah Kouzi, Georges Khamis, Elfi Ducrocq, Sophie Hamard, Fabrice Gouilleux, Kazem Zibara, Olivier Herault, Frederic Mazurier
Journal: Blood (2017)
Review of Cryptosporidium and Giardia in the eastern part of Europe, 2016
Authors: Judit Plutzer, Brian Lassen, Pikka Jokelainen, Olgica Djurković-Djaković, István Kucsera, Elisabeth Dorbek-Kolin, Barbara Šoba, Tamás Sréter, Kálmán Imre, Jasmin Omeragić, Aleksandra Nikolić, Branko Bobić, Tatjana Živičnjak, Snježana Lučinger, Lorena Lazarić Stefanović, Jasmina Kučinar, Jacek Sroka, Gunita Deksne, Dace Keidāne, Martin Kváč, Zuzana Hůzová, Panagiotis Karanis
Journal: Eurosurveillance (2018)

Introduction This paper reviews the current knowledge and understanding of Cryptosporidium spp . and Giardia spp. in humans, animals and the environment in 10 countries in the eastern part of Europe: Bosnia and Herzegovina, Croatia, Czech Republic, Estonia, Hungary, Latvia, Poland, Romania, Serbia and Slovenia. Methods: Published scientific papers and conference proceedings from the international and local literature, official national health service reports, national databases and doctoral theses in local languages were reviewed to provide an extensive overview on the epidemiology, diagnostics and research on these pathogens, as well as analyse knowledge gaps and areas for further research. Results: Cryptosporidium spp. and Giardia spp. were found to be common in eastern Europe, but the results from different countries are difficult to compare because of variations in reporting practices and detection methodologies used. Conclusion: Upgrading and making the diagnosis/detection procedures more uniform is recommended throughout the region. Public health authorities should actively work towards increasing reporting and standardising reporting practices as these prerequisites for the reported data to be valid and therefore necessary for appropriate control plans.
Abstract 12090: Seattle Heart Failure Model and Seattle Proportional Risk Model Together Identify Patients Most Likely to Benefit From Primary Prevention ICDs - An NCDR Analysis
Authors: Kenneth C Bilchick, Alan Cheng, Yongfei Wang, Jeptha Curtis, Kumar Dharmarajan, Wayne Levy
Journal: Circulation (2016)

Introduction: Risk models are greatly needed to target appropriate patients for implantable cardioverter defibrillators (ICDs) in clinical practice for primary prevention of sudden death. Hypothesis: We hypothesized that the Seattle Heart Failure Model (SHFM) for overall survival and the Seattle Proportional Risk Model (SPRM) for proportional risk of arrhythmic death (AD) would identify National Cardiovascular Data Registry (NCDR) ICD Registry patients most likely to have improved survival with versus without an ICD. Methods: SHFM and SPRM scores were determined for patients with and without ICDs (ICD Registry versus a control group derived from the University of Washington Registry, Italian Heart Failure Registry, Swedish Heart Failure Registry, COMET, Val-HeFT, and PRAISE trials). Multivariable Cox proportional hazards regression was used to evaluate adjusted associations of SPRM and SHFM with survival over 5 years from the Social Security Death Index. Results: Among 98,846 patients (87,914 with ICDs and 10,932 without ICDs), increasing SFHM risk was strongly associated with decreased survival (P&lt;0.0001). Compared with patients having a lower SPRM-predicted proportional risk of AD, patients with a higher predicted proportional AD risk had approximately twice the ICD survival benefit (HR 0.602 [95% CI 0.537-0.675] for SPRM quintile 5 versus HR 0.793 [0.736-0.855] for SPRM quintile 1). The ICD-SPRM interaction was highly significant (Figure). The ICD did not improve adjusted survival versus controls in the 25% of patients with higher predicted survival (SHFM &lt; mean) but a lower proportional AD risk (SPRM &lt; mean) (HR 0.921, 95% CI 0.787-1.08, P=0.31); however, survival in patients with opposite findings (SHFM &gt; mean, SPRM &gt; mean) was greatly improved versus controls (HR 0.599, 95% CI 0.530-0.677, P&lt;0.0001). Conclusions: The SHFM and SPRM scores together identify real-world patients most likely to benefit from primary prevention ICD implantation.
Real-World Evidence for Durable Treatment Responses after Toxicity Related Discontinuation of Idelalisib
Authors: Erin Bange, Chadi Nabhan, Danielle M. Brander, Nicole Lamanna, Chaitra S. Ujjani, Christina Howlett, Alan P Skarbnik, Brian T. Hill, Bruce D. Cheson, Clive S Zent, Jeffrey J. Pu, Allison M. Winter, Krista Isaac, Kaitlin Kennard, Colleen Timlin, Colleen Dorsey, Sunita Dwivedy Nasta, Jakub Svoboda, Daniel J. Landsburg, Stephen J. Schuster, Paul M. Barr, Anthony R. Mato
Journal: Blood (2017)
Patient-Reported Quality of Life (QoL) Following CTL019 Infusion in Adult Patients (pts) with Relapsed/Refractory (r/r) Diffuse Large B-Cell Lymphoma (DLBCL)
Authors: Richard Thomas Maziarz, Michael R. Bishop, Constantine S. Tam, Peter Borchmann, Ulrich Jaeger, Joseph P. McGuirk, Edmund K. Waller, Samantha Jaglowski, Charalambos Andreadis, Stephen Ronan Foley, Isabelle Fleury, Stephan Mielke, Jason R. Westin, Phoebe Joy Ho, Veronika Bachanova, Harald Holte, John M. Magenau, Oezlem Anak, Lida Bubuteishvili Pacaud, Siegbert Guenther, Jie Zhang, Lawrence Rasouliyan, Feng Tai, Gilles Salles, Stephen J. Schuster
Journal: Blood (2017)
Why episodic memory may not be for communication
Authors: Felipe De Brigard, Bryce Gessell
Journal: Behavioral and Brain Sciences (2018)

Three serious challenges to Mahr & Csibra's (M&C's) proposal are presented. First, we argue that the epistemic attitude that they claim is unique to remembering also applies to some forms of imaginative simulations that aren't memories. Second, we argue that their account cannot accommodate critical neuropsychological evidence. Finally, we argue that their proposal looks unconvincing when compared to more parsimonious evolutionary accounts.