tbuckley/cabot-search huggingface dataset:
Long‐term outcomes of patients undergoing simultaneous liver transplantation and sleeve gastrectomy
Authors: Daniel Zamora‐Valdes, Kymberly D. Watt, Todd A. Kellogg, John J. Poterucha, Sara R. Di Cecco, Nicki M. Francisco‐Ziller, Timucin Taner, Charles B. Rosen, Julie K. Heimbach
Journal: Hepatology (2018)

Obesity is increasingly common before and after liver transplantation (LT), yet optimal management remains unclear. The aim of this study was to analyze the long-term outcomes for obese patients undergoing LT, including a noninvasive weight loss program and combined LT and sleeve gastrectomy (SG). Since 2006, all patients referred for LT with a body mass index (BMI) ≥35 kg/m2 were enrolled. Patients who achieved weight loss (BMI <35) underwent LT alone, and those who did not underwent simultaneous LT + SG. Analysis of long-term outcomes for patients ≥3 years posttransplant was performed. Since 2006, there were 36 in the weight loss intervention (LT cohort) and 13 in the LT + SG cohort with >3 years of follow-up, whereas overall, a total of 29 patients underwent LT + SG. Patients in the LT cohort had less severe obesity at enrollment (40.0 ± 2.7 vs. LT + SG cohort 46.0 ± 4.5; P < 0.001). In the LT cohort, 83.3% (30 of 36) achieved >10% loss in total body weight (TBW) pre-LT. Three years posttransplant, 29.4% of patients in the LT cohort maintained >10% loss in TBW, whereas 100% of the LT + SG patients did (P < 0.001). Patients who underwent LT + SG maintained a significantly higher percentage of total body weight loss after 3 years of follow-up (LT cohort 3.9 ± 13.3% vs. LT + S G cohort 34.8 ± 17.3%; P < 0.001). Patients in the LT + SG also had a lower prevalence of hypertension, insulin resistance, and hepatic steatosis and required fewer antihypertensive medications and lipid agents at last follow-up.Whereas weight loss before transplantation was achieved by obese patients, weight regain was common in the LT cohort. Combined LT + SG resulted in more effective and more durable weight loss, as well as fewer metabolic complications at last follow-up. (Hepatology 2018).
Abstract P5-22-19: Nipple sparing mastectomy in unselect patients: Experience of an academic center in the south of Brazil
Authors: A Frasson, F Zerwes, A Souza, N Rossato, I Miranda, V Trindade, B Vollbrecht, M Santos, J Viegas
Journal: Cancer Research (2018)

Abstract INTRODUCTION: Nipple sparing mastectomy (NSM) consists in the complete excision of the breast gland, mantaining the subcutaneous tissue, skin and nipple-areola complex (NAC). Recently, the NSM was developed as a therapeutic option not just for the patients that need risk-reducing surgery, but also for patients that have tumors not involving the NAC. OBJECTIVES: Evaluate the overall survival, disease-free survival and local recurrence of the patients that underwent NSM. The only exclusion criteria for NSM was lesion at the NAC. MATERIAL AND METHODS: Retrospective study that evaluate the number of cases of NSM performed between 2003 and 2015 in a private sector in the south of Brazil. RESULTS: A total of 224 patients underwent NSM during the period of 2003-2015. The mean age was 47 years. From the total, 43 patients underwent risk-reducing NSM and 181 therapeutic NSM (64 unilateral and 117 bilateral). In those cases of bilateral procedures all of them underwent risk-reducing surgery on the contralateral breast (there were no bilateral cancers). Of this 181 cases, 108 (59%) have familiar history of breast cancer, considering first, second and third-degree relatives. Twenty six patients (14%) have history of previous breast cancer diagnosed. In this group of 181 patients with therapeutic NSM, 29 (16%) developed any unfavorable outcomes, 13 (7%) local recurrence, 4 (2%) ipsilateral node recurrence, 3 (1,6%) contralateral recurrence and 9 (5%) distant metastasis. None of the local recurrences occurred at the NAC, neither the cited unfavorable outcomes occurred in the risk-reducing setting. In a median follow-up of 47,7 months, the overall survival was 95% (8 deaths related to breast cancer) and the disease-free survival was 83,7%. CONCLUSIONS: The overall survival rates of 95% at 47 months of follow-up is similar to the literature rates, that range from 93 to 97% in 5 years, depending on study's inclusion criterias. In our study, 14% of patients had previous breast cancer and 59% of patients treated for breast cancer by NSM had positive familiar history of breast cancer. This results in an unselected group of patients confirms the safety of this therapeutic method as an option for breast cancer patients. Citation Format: Frasson A, Zerwes F, Souza A, Rossato N, Miranda I, Trindade V, Vollbrecht B, Santos M, Viegas J. Nipple sparing mastectomy in unselect patients: Experience of an academic center in the south of Brazil [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P5-22-19.
ADULT BONE MARROW CELL THERAPY IMPROVES LEFT VENTRICULAR FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS UTILIZING CARDIAC MAGNETIC RESONANCE IMAGING
Authors: Anweshan Samanta, Muhammad Afzal, Amy Cantilena, Ipsita Samanta, Siva Sagar Taduru, Shubha D. Roy, Buddhadeb Dawn
Journal: Journal of the American College of Cardiology (2018)
Assessing Tremor and Adverse Events in Patients With Tremor-Dominant Parkinson Disease Undergoing Focused Ultrasound Thalamotomy
Authors: Ilana Schlesinger, Alon Sinai, Menashe Zaaroor
Journal: JAMA Neurology (2018)

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Medicine must be more accessible to people from all backgrounds, says social mobility tsar
Authors: Helen Jaques
Journal: BMJ (2012)

Medicine lags behind other professions such as law and the civil service in prioritising social mobility and “has a long way to go” with respect to opening up access to people from a diverse range of backgrounds, a report by the government’s social mobility adviser has said.

The Fair Access to Professional Careers report, written by Labour MP Alan Milburn, says that, although medicine has made “impressive progress” in recent years in recruiting female doctors and doctors from black and minority ethnic backgrounds, it must put more focus on broadening its social intake and raising social mobility.

“The profession itself recognises that the skills that modern doctors require include far greater understanding …
A Review on Tumor-Treating Fields (TTFields): Clinical Implications Inferred From Computational Modeling
Authors: Cornelia Wenger, Pedro C. Miranda, Ricardo Salvador, Axel Thielscher, Zeev Bomzon, Moshe Giladi, Maciej M. Mrugala, Anders R. Korshoej
Journal: IEEE Reviews in Biomedical Engineering (2018)

Tumor-treating fields (TTFields) are a cancer treatment modality that uses alternating electric fields of intermediate frequency (~100-500 kHz) and low intensity (1-3 V/cm) to disrupt cell division. TTFields are delivered by transducer arrays placed on the skin close to the tumor and act regionally and noninvasively to inhibit tumor growth. TTFields therapy is U.S. Food and Drug Administration approved for the treatment of glioblastoma multiforme, the most common and aggressive primary human brain cancer. Clinical trials testing the safety and efficacy of TTFields for other solid tumor types are underway. The objective of this paper is to review computational approaches used to characterize TTFields. The review covers studies of the macroscopic spatial distribution of TTFields generated in the human head, and of the microscopic field distribution in tumor cells. In addition, preclinical and clinical findings related to TTFields and principles of its operation are summarized. Particular emphasis is put on outlining the potential clinical value inferred from computational modeling.
How can I find out about career prospects as a clinical pharmacologist in the United Kingdom?
Authors: Emma Baker
Journal: BMJ (2005)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site. <b>www.bmjcareers.com/advicezone</b>
Value of Adding Predictive Clinical Decision Tools to Spine Surgery
Authors: Michael P. Steinmetz, Thomas Mroz
Journal: JAMA Surgery (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Two Primary Colon Cancers Shown on FDG PET/CT Performed to Evaluate Possible Lung Metastases From Bladder Cancer
Authors: Ruixue Cui, Fang Li, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2009)

Patients with bladder cancer have a significantly higher likelihood of having a metachronous second primary malignancy. A 72-year-old man with a history of bladder cancer underwent FDG PET/CT scan to evaluate possible pulmonary metastases. The PET/CT images demonstrated that there were metabolically active lung nodules which were consistent with malignancy. In addition, foci of hypermetabolism were noted in the liver, the left adrenal gland and the ascending and descending colon. Histopathological examination demonstrated that the foci of abnormal FDG activity in the colon were due to 2 distinct primary colon cancers. Due to the higher prevalence of a metachronous second primary tumor in patients with bladder cancer, caution is warranted in interpreting possible metastatic lesions on FDG PET/CT imaging in this clinical setting.
IMMUNE-RELATED MYOCARDITIS AND CONDUCTION ABNORMALITIES SECONDARY TO COMBINATION IMMUNOTHERAPY TREATMENT WITH IPILIMUMAB/NIVOLUMAB IN A PATIENT WITH MERKEL CELL CARCINOMA
Authors: Miguel Gonzalez Velez, Giselle Suero-Abreu, Narjust Duma, Martin Gutierrez, Tracy Proverbs-Singh
Journal: Journal of the American College of Cardiology (2018)
I am at second MB stage at medical school and I'd like to pursue engineering now. Is it possible to combine medicine and engineering, and what are my options?
Authors: Brian Angus
Journal: BMJ (2005)

Have a career or related problem that needs answering? Can9t find the right person to point you in the right direction? Log on to the Advice Zone (www.bmjcareers.com/advicezone) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site.
Preschool Multiple-Breath Washout Testing. An Official American Thoracic Society Technical Statement
Authors: Paul D. Robinson, Philipp Latzin, Kathryn A. Ramsey, Sanja Stanojevic, Paul Aurora, Stephanie D. Davis, Monika Gappa, Graham L. Hall, Alex Horsley, Renee Jensen, Sooky Lum, Carlos Milla, Kim G. Nielsen, Jessica E. Pittman, Margaret Rosenfeld, Florian Singer, Padmaja Subbarao, Per M. Gustafsson, Felix Ratjen
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Section:ChooseTop of pageAbstract <<ContentsOverviewIntroductionMethodsBackgroundTechnical Considerations ...Physiological and Develop...Reference Data for Presch...MBW Use in Preschool Inte...Minimal Clinically Import...Future Work and Conclusio...ReferencesCITING ARTICLES
Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort
Authors: Sanjeev Budhathoki, Akihisa Hidaka, Taiki Yamaji, Norie Sawada, Sachiko Tanaka-Mizuno, Aya Kuchiba, Hadrien Charvat, Atsushi Goto, Satoshi Kojima, Natsuki Sudo, Taichi Shimazu, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane, Motoki Iwasaki
Journal: BMJ (2018)

To evaluate the association between pre-diagnostic circulating vitamin D concentration and the subsequent risk of overall and site specific cancer in a large cohort study.Nested case-cohort study within the Japan Public Health Center-based Prospective Study cohort.Nine public health centre areas across Japan.3301 incident cases of cancer and 4044 randomly selected subcohort participants.Plasma concentration of 25-hydroxyvitamin D measured by enzyme immunoassay. Participants were divided into quarters based on the sex and season specific distribution of 25-hydroxyvitamin D among subcohorts. Weighted Cox proportional hazard models were used to calculate the multivariable adjusted hazard ratios for overall and site specific cancer across categories of 25-hydroxyvitamin D concentration, with the lowest quarter as the reference.Incidence of overall or site specific cancer.Plasma 25-hydroxyvitamin D concentration was inversely associated with the risk of total cancer, with multivariable adjusted hazard ratios for the second to fourth quarters compared with the lowest quarter of 0.81 (95% confidence interval 0.70 to 0.94), 0.75 (0.65 to 0.87), and 0.78 (0.67 to 0.91), respectively (P for trend=0.001). Among the findings for cancers at specific sites, an inverse association was found for liver cancer, with corresponding hazard ratios of 0.70 (0.44 to 1.13), 0.65 (0.40 to 1.06), and 0.45 (0.26 to 0.79) (P for trend=0.006). A sensitivity analysis showed that alternately removing cases of cancer at one specific site from total cancer cases did not substantially change the overall hazard ratios.In this large prospective study, higher vitamin D concentration was associated with lower risk of total cancer. These findings support the hypothesis that vitamin D has protective effects against cancers at many sites.
Study reports high levels of “burnout” among GPs
Authors: Helen Jaques
Journal: BMJ (2012)

More than a third of GPs experience psychological “burnout,” with male doctors particularly affected, research published in BMJ Open has found (2012;2:e000274, doi:10.1136/bmjopen-2011-000274).

The study of 564 GPs in Essex found that 46% reported high levels of emotional exhaustion; 42% had negative and cynical attitudes towards their patients (depersonalisation); and 34% experienced a reduced sense of personal accomplishment in their work with patients.

However, GPs’ consultations with patients were not affected by their feelings of burnout, as rated by the patients themselves and by an independent observer, indicating that GPs are able to maintain a professional approach to patients despite any personal distress.

The authors describe these high levels of burnout in …
Public health workforce has not shrunk, MPs hear
Authors: Matthew Limb
Journal: BMJ (2016)

Officials from Public Health England have denied that England’s public health workforce has reduced. Public Health England’s medical director told the House of Commons Health Committee that there was “no evidence” of significant reductions in trained public health specialists in posts. But the organisation said that there was some uncertainty about the statistics and that the data needed further analysis.

MPs on the Health Committee questioned officials on 7 June as part of their inquiry into the effect on the public health system of the Health and Social Care Act 2012. Under the legislation responsibility for public health transferred from the NHS to local government in 2013.

Committee member Maggie Throup, the Conservative MP for Erewash, said …
NEW BIOMARKERS ASSOCIATED WITH CARDIOVASCULAR DEATH IN PATIENTS WITH ATRIAL FIBRILLATION USING MULTIMARKER SCREENING: INSIGHTS FROM THE ARISTOTLE TRIAL
Authors: Tymon Pol, Ziad Hijazi, Johan Lindbäck, Jonas Oldgren, John Alexander, Christopher Granger, Renato Lopes, Agneta Siegbahn, Lars Wallentin
Journal: Journal of the American College of Cardiology (2018)
Effects of Ticagrelor, Prasugrel, or Clopidogrel at Steady State on Endothelial Function
Authors: Sara Ariotti, Maarten van Leeuwen, Salvatore Brugaletta, Sergio Leonardi, K. Martijn Akkerhuis, Stefano F. Rimoldi, Gladys N. Janssens, Luis Ortega-Paz, Umberto Gianni, Jan C. van den Berge, Alexios Karagiannis, Stephan Windecker, Marco Valgimigli
Journal: Journal of the American College of Cardiology (2018)
Consultant post expansion slowed by financial pressure
Authors: Caroline White
Journal: BMJ (2013)

Financial pressure on hospitals after 2010 slowed the expansion of consultant posts, data from the Royal College of Physicians suggest.

The college’s report1 of its latest census shows that the rate of increase in the number of consultants in England halved between 2009 and 2011, contracting from 10.2% to 5.2%. The number of consultants in England and Wales rose to 11 810 in 2011.

Andrew Goddard, director of the college’s Medical Workforce Unit, is the author of a report on the college’s census of consultants. He told BMJ Careers: “If you look at the money spent [by primary care trusts] on secondary care, you can see that it …
Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors
Authors: Xiong Guo, Zhiyue Zhao, Dawei Chen, Mingxi Qiao, Feng Wan, Dongmei Cun, Yi Sun, Mingshi Yang
Journal: Asian Journal of Pharmaceutical Sciences (2018)

Co-delivery of anti-cancer drugs is promising to improve the efficacy of cancer treatment. This study was aiming to investigate the potential of concurrent delivery of resveratrol (RES) and docetaxel (DTX) via polymeric nanocarriers to treat breast cancer. To this end, methoxyl poly(ethylene glycol)-poly(d,l-lactide) copolymer (mPEG-PDLA) was prepared and characterized using FTIR and 1H NMR, and their molecular weights were determined by GPC. Isobologram analysis and combination index calculation were performed to find the optimal ratio between RES and DTX to against human breast adenocarcinoma cell line (MCF-7 cells). Subsequently, RES and DTX were loaded in the mPEG-PDLA micelles simultaneously, and the morphology, particle size distribution, in vitro release, pharmacokinetic profiles, as well as cytotoxicity to the MCF-7 cells were characterized. IC50 of RES and DTX in MCF-7 cells were determined to be 23.0 µg/ml and 10.4 µg/ml, respectively, while a lower IC50 of 4.8 µg/ml of the combination of RES and DTX was obtained. The combination of RES and DTX at a ratio of 1:1 (w/w) generated stronger synergistic effect than other ratios in the MCF-7 cells. RES and DTX loaded mPEG-PDLA micelles exhibited prolonged release profiles, and enhanced cytotoxicity in vitro against MCF-7 cells. The AUC(0→t) of DTX and RES in mPEG-PDLA micelles after i.v. administration to rats were 3.0-fold and 1.6-fold higher than that of i.v. injections of the individual drugs. These findings indicated that the co-delivery of RES and DTX using mPEG-PDLA micelles could have better treatment of tumors.
Effect and impact of mechanical ventilation in myotonic dystrophy type 1: a prospective cohort study
Authors: Ghilas Boussaïd, Hélène Prigent, Pascal Laforet, Jean-Claude Raphaël, Djillali Annane, David Orlikowski, Frédéric Lofaso
Journal: Thorax (2018)

Few studies have assessed the impact of home ventilation in patients with myotonic dystrophy type 1 (DM1) and no specific recommendations are available. We assessed the survival associated with category of home ventilation adherence of patients with DM1 followed up at a home ventilation unit using a Cox proportional hazards model. 218 patients were included; those who refused or delayed their acceptance of non-invasive ventilation were at higher risk for severe events (invasive ventilation or death) (P=0.03). Risk of death was associated with orthopnoea (HR 2.37; 95% CI 1.17 to 4.80; P<0.02) and adherence category (100 to 90% vs >75%: HR 3.26; 95% CI 1.32 to 8.04; P<0.03). Failure to use home ventilation as prescribed may be associated with increased mortality in patients with DM1.
EMERGENT ECHOCARDIOGRAPHY-GUIDED TRANSCATHETER AORTIC VALVE REPLACEMENT IN A SEVERE AORTIC STENOSIS PATIENT PRESENTING WITH CARDIAC ARREST
Authors: Ali Hama Amin, Partho Sengupta, Lawrence Wei, Fahad Alqahtani, Bilal Munir, Mohamad Alkhouli
Journal: Journal of the American College of Cardiology (2018)
Pregnancy and Motherhood During Surgical Training
Authors: Erika L. Rangel, Douglas S. Smink, Manuel Castillo-Angeles, Gifty Kwakye, Marguerite Changala, Adil H. Haider, Gerard M. Doherty
Journal: JAMA Surgery (2018)

Although family priorities influence specialty selection and resident attrition, few studies describe resident perspectives on pregnancy during surgical training.
Is Time of the Essence? The Impact of Time of Hospital Presentation in Acute Heart Failure
Authors: Lukasz P. Cerbin, Andrew P. Ambrosy, Stephen J. Greene, Paul W. Armstrong, Javed Butler, Adrian Coles, Adam D. DeVore, Justin A. Ezekowitz, Adrian F. Hernandez, Marco Metra, Randall C. Starling, Wilson Tang, John R. Teerlink, Adriaan A. Voors, Angie Wu, Christopher M. O’Connor, Robert J. Mentz
Journal: JACC Heart Failure (2018)
Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database
Authors: Cynthia J. Grondin, Allan Peter Davis, Thomas C. Wiegers, Jolene A. Wiegers, Carolyn J. Mattingly
Journal: Environmental Health Perspectives (2018)

Summary: The Comparative Toxicogenomics Database (CTD; http://ctdbase.org) is a free resource that provides manually curated information on chemical, gene, phenotype, and disease relationships to advance understanding of the effect of environmental exposures on human health. Four core content areas are independently curated: chemical–gene interactions, chemical–disease and gene–disease associations, chemical–phenotype interactions, and environmental exposure data (e.g., effects of chemical stressors on humans). Since releasing exposure data in 2015, we have vastly increased our coverage of chemicals and disease/phenotype outcomes; greatly expanded access to exposure content; added search capability by stressors, cohorts, population demographics, and measured outcomes; and created user-specified displays of content. These enhancements aim to facilitate human studies by allowing comparisons among experimental parameters and across studies involving specified chemicals, populations, or outcomes. Integration of data among CTD's four content areas and external data sets, such as Gene Ontology annotations and pathway information, links exposure data with over 1.8 million chemical–gene, chemical–disease and gene–disease interactions. Our analysis tools reveal direct and inferred relationships among the data and provide opportunities to generate predictive connections between environmental exposures and population-level health outcomes. https://doi.org/10.1289/EHP2873
Abstract 20596: Cumulative Hospital-Related Costs Do not Differ Between the Norwood and Hybrid Strategies for Single Ventricle Palliation
Authors: Amine Mazine, James M Meza, Anne-Marie Guerguerian, Christoph Haller, Steven M Schwartz, Brian W McCrindle, Glen S Van Arsdell, Osami Honjo, Christopher A Caldarone
Journal: Circulation (2016)

Introduction: Limited data exist on the health care costs associated with the Norwood and Hybrid strategies for single ventricle palliation. We compared the cumulative hospital-related costs of pat...