tbuckley/cabot-search huggingface dataset:
Etude de la fréquence et de la répartition de la métaplasie intestinale au sein de l’endobrachyoesophage
Authors: M Jego, A Volant, F Cholet, K Bideau, L Doucet, JB Nousbaum, H Gouérou, M Robaszkiewicz
Journal: Endoscopy (2004)

Introduction: La présence de foyers de métaplasie intestinale est nécessaire pour affirmer le diagnostic d’endobrachyoesophage (EBO). La distribution de la métaplasie intestinale au niveau des EBO est mal connue et impose de réaliser des biopsies multiples étagées. Les buts de l’étude étaient de déterminer la prévalence de la métaplasie intestinale au sein des longs et des courts segments de muqueuse glandulaire de l’ésophage et d’analyser la topographie de la métaplasie intestinale au sein des EBO longs. Patients et Méthodes: L’étude a porté sur l’endoscopie initiale réalisée chez 112 patients inscrits dans un programme de surveillance endoscopique. Soixante-douze patients ayant un long segment de muqueuse glandulaire de l’ésophage (groupe I) et 40 patients ayant un court segment (groupe II) ont eu des biopsies multiples selon un protocole standardisé. 1163 biopsies ont été analysées au total: 949 biopsies dans le groupe I et 214 biopsies dans le groupe II. Résultats: Une métaplasie intestinale a été identifiée au niveau de 650 biopsies dans le groupe I (68,5%) et de 50 biopsies dans le groupe II (23,4%) (p < 10 – 7). La proportion des biopsies présentant des foyers de métaplasie intestinale augmentait significativement avec la hauteur de l’EBO. Le diagnostic d’EBO a été confirmé en histologie chez la totalité des patients du groupe I et chez 45% des patients du groupe II. Au niveau des EBO longs, la métaplasie intestinale était plus fréquemment observée au niveau des ⅔ proximaux de l’EBO qu’au niveau du ⅓ distal (p < 10 – 7). Il existait 3 types de répartition de la métaplasie intestinale au sein des EBO longs: unifocale, multifocale et diffuse. La prévalence de la dysplasie était de 15% pour les EBO longs et de 11% pour les EBO courts (NS). Conclusion: La répartition des foyers de métaplasie intestinale au sein des EBO est hétérogène. Devant le risque d’erreur d’échantillonnage, les recommandations actuelles concernant les prélèvements biopsiques restent d’actualité dans l’attente de la validation d’une technique permettant d’orienter les biopsies telles que la chromoendoscopie ou l’endoscopie grossissante.
Erratum: Tuberculosis reporting trends with infliximab and etanercept (Annals of the Rheumatic Diseases (2004) 63:SUPPL I (S414-S415))
Authors: E. C. Keystone, C. O. Bingham, V. Belozeroff, L. Hadjiaghai, J. Veith, A. Shibata, W. Wallis, S. Zhao
Journal: Annals of the Rheumatic Diseases (2004)
The emerging role of transient receptor potential channels in chronic lung disease
Authors: Maria G. Belvisi, Mark A. Birrell
Journal: European Respiratory Journal (2017)

Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis are a major and increasing global health burden with a high unmet need. Drug discovery efforts in this area have been largely disappointing and so new therapeutic targets are needed. Transient receptor potential ion channels are emerging as possible therapeutic targets, given their widespread expression in the lung, their role in the modulation of inflammatory and structural changes and in the production of respiratory symptoms, such as bronchospasm and cough, seen in chronic lung disease.
EPIDEMIOLOGICAL INJURY SURVEILLANCE SYSTEM DURING MAJOR ATHLETICS CHAMPIONSHIPS: WHAT IS THE METHODOLOGICAL QUALITY?
Authors: Pascal EDOUARD, Pedro BRANCO, Juan-Manuel ALONSO, Astrid JUNGE
Journal: British Journal of Sports Medicine (2017)

Background Epidemiological studies with injury surveillance during major athletics championships are of interest to improve the knowledge on injury incidence and prevalence in this context. However, the quality of the injury surveillance system has an influence on the quality of the data. Objective To analyse the quality of and compliance with the injury surveillance system used during major athletics championships. Design Prospective study. Setting 14 international athletics championships from 2007 to 2015; Elite athletics level. Participants A total of 1560 countries, 15463 registered athletes and the 14 local organizing committee medical organizations (LOC). Main Outcome Measurements The quality of the injury surveillance system was analysed following the Centre for Disease Control and Prevention guidelines including the following parameters: simplicity, flexibility, data quality (completeness and validity of data), acceptability, sensitivity, positive predictive value, representativeness, stability and availability, timeliness, and security and confidentiality. In addition, medical team participation, coverage of athletes by medical teams, response rate of daily report forms and completeness of injury data were analysed. Results On average 41.7±17.4% (mean±standard deviation) of all registered countries participated in the injury surveillance project, accounting for a coverage of athletes of 79.5±10.2% of all registered athletes. Their medical staff returned 89.2±8.4% of the expected injury report forms (information is missing for one championship). The completeness of injury data provided by medical teams and LOC averaged 95.8±6.5%. National medical teams reported 60.6±16.6% of all injuries, and LOC 28.7±15.0% whereas 10.6±6.5% of injuries were reported by both. Conclusions The injury surveillance system used during international athletics championships had good methodological qualities, with high national medical team participation, coverage of athletes, response rates and completeness of injury data. These parameters should be systematically given when reporting injury surveillance studies to show the methodological quality of the study.
Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and <i>DSM-IV</i> Alcohol Use Disorder in the United States, 2001-2002 to 2012-2013
Authors: Bridget F. Grant, S. Patricia Chou, Tulshi D. Saha, Roger P. Pickering, Bradley T. Kerridge, W. June Ruan, Boji Huang, Jeesun Jung, Haitao Zhang, Amy Fan, Deborah S. Hasin
Journal: JAMA Psychiatry (2017)

Lack of current and comprehensive trend data derived from a uniform, reliable, and valid source on alcohol use, high-risk drinking, and DSM-IV alcohol use disorder (AUD) represents a major gap in public health information.To present nationally representative data on changes in the prevalences of 12-month alcohol use, 12-month high-risk drinking, 12-month DSM-IV AUD, 12-month DSM-IV AUD among 12-month alcohol users, and 12-month DSM-IV AUD among 12-month high-risk drinkers between 2001-2002 and 2012-2013.The study data were derived from face-to-face interviews conducted in 2 nationally representative surveys of US adults: the National Epidemiologic Survey on Alcohol and Related Conditions, with data collected from April 2001 to June 2002, and the National Epidemiologic Survey on Alcohol and Related Conditions III, with data collected from April 2012 to June 2013. Data were analyzed in November and December 2016.Twelve-month alcohol use, high-risk drinking, and DSM-IV AUD.The study sample included 43 093 participants in the National Epidemiologic Survey on Alcohol and Related Conditions and 36 309 participants in the National Epidemiologic Survey on Alcohol and Related Conditions III. Between 2001-2002 and 2012-2013, 12-month alcohol use, high-risk drinking, and DSM-IV AUD increased by 11.2%, 29.9%, and 49.4%, respectively, with alcohol use increasing from 65.4% (95% CI, 64.3%-66.6%) to 72.7% (95% CI, 71.4%-73.9%), high-risk drinking increasing from 9.7% (95% CI, 9.3%-10.2%) to 12.6% (95% CI, 12.0%-13.2%), and DSM-IV AUD increasing from 8.5% (95% CI, 8.0%-8.9%) to 12.7% (95% CI, 12.1%-13.3%). With few exceptions, increases in alcohol use, high-risk drinking, and DSM-IV AUD between 2001-2002 and 2012-2013 were also statistically significant across sociodemographic subgroups. Increases in all of these outcomes were greatest among women, older adults, racial/ethnic minorities, and individuals with lower educational level and family income. Increases were also seen for the total sample and most sociodemographic subgroups for the prevalences of 12-month DSM-IV AUD among 12-month alcohol users from 12.9% (95% CI, 12.3%-17.5%) to 17.5% (95% CI, 16.7%-18.3%) and 12-month DSM-IV AUD among 12-month high-risk drinkers from 46.5% (95% CI, 44.3%-48.7%) to 54.5% (95% CI, 52.7%-56.4%).Increases in alcohol use, high-risk drinking, and DSM-IV AUD in the US population and among subgroups, especially women, older adults, racial/ethnic minorities, and the socioeconomically disadvantaged, constitute a public health crisis. Taken together, these findings portend increases in many chronic comorbidities in which alcohol use has a substantial role.
95% PREVALENCE OF ABNORMALITY ON HIP MRI IN ELITE ACADEMY LEVEL RUGBY UNION; A CLINICAL AND IMAGING STUDY OF HIP DISORDERS
Authors: Gareth Farrell, F Wilson, K Denvir, B O'Connell, E Irwin, C Gissane, F McGrath
Journal: British Journal of Sports Medicine (2017)

Background Hip disorders are common in field based athletes. To date there have been no studies profiling hips in elite level rugby. Objective Identify the prevalence of hip disorders (clinical and imaging) in elite academy rugby union players comparing to active controls. Design Cross-sectional, case-control study. Setting Professional Rugby Union Club. Patients (or Participants) 20 male professional Rugby Academy players and 20 age, activity and gender matched controls. Exclusion criteria were previous hip surgery, or hip, groin, or lumbar pathology within the previous six months. Interventions (or Assessment of Risk Factors) Participants were assessed on a single day using a HAGOS questionnaire, clinical tests (FABER and Thomas Test) and range of motion of the hip. The rugby playing cohort underwent dedicated non-arthrographic 3T MRI of the hip in three plains. Images were blind reviewed by two experienced musculoskeletal radiologists. Controls were clinically tested only. Main Outcome Measurements Prevalence of hip Symptoms (HAGOS), clinical tests and range of motion of the hip and prevalence of abnormality on MRI. Results The rugby cohort had significantly reduced hip rotation range, extension and FABER scores compared to the controls. Symptoms were reported by 65% of rugby players versus 15% in controls. There was a 95% prevalence of abnormality on MRI, 80% labral pathology, 60% CAM deformity and 25% had chondral wear. Conclusions There was a high prevalence of hip abnormality (95%) on MRI in rugby players (80% labral pathology, 60% CAM defect). The percentage reporting symptoms was lower at 65% although this was significantly higher than (non-rugby) matched controls at 15%. Rugby players demonstrated significantly reduced range of movement of the hip compared to controls. Further prospective research is required.
Romantic expectations of out of hours care cost GPs dear
Authors: F. Wilson
Journal: BMJ (1995)

EDITOR,--J N Rawlinson's pain, distress, and guilt at having taken part in an unsuccessful attempt to resuscitate a neighbour are evident, and the author is clearly angry at the deputising doctor for having taken so long to arrive and for then holding up the paramedics.1 But surely we should be looking beneath the surface of this problem at the causes.

The patient's husband said that “[our] own doctor … would have stayed with me”; Rawlinson states that their own doctor would have cared for the family. This is a romantic …
LANDING-RELATED ANKLE INJURIES DO NOT OCCUR IN PLANTARFLEXION AS ONCE THOUGHT: A VIDEO ANALYSIS OF ANKLE INJURIES IN WORLD-CLASS VOLLEYBALL FROM THE FIVB INJURY SURVEILLANCE SYSTEM
Authors: Christopher Skazalski, Jacek Kruczynski, Martin Aase Bahr, Tone Bere, Rod Whiteley, Roald Bahr
Journal: British Journal of Sports Medicine (2017)

Background Ankle sprains are the most prevalent injury in volleyball and it is suggested they result from player contact at the net. Traditionally, ankle sprains are thought to happen in a plantarflexed position, but case studies suggest plantarflexion may not be involved. Objective To describe the injury situations and mechanisms for ankle injuries in elite volleyball based on systematic video analyses. Design Descriptive video analysis. Setting National teams participating in major Fédération Internationale de Volleyball (FIVB) senior-level tournaments. Material All acute ankle injuries with subsequent time-loss (n=32) reported through the (FIVB) Injury Surveillance System (ISS) 2010–2014. Of these, video footage of 24 injuries was available for analysis. Assessment of Risk Factors Injury situation variables included playing situation, player positions, and center line infringement. Variables examining injury mechanisms included lower extremity (ankle, knee, hip) joint positions at first contact and the index injury frame, joint movement between initial contact and the index frame, and the relationship between ankle dorsiflexion and supination. Results The majority of injuries occurred during blocking (n=15) and attacking (n=6). Injuries to blockers resulted from landing on an opponent (n=11) or teammate (n=4). Attacking injuries mostly occurred when a backrow player landed on a front row teammate (n=4). When landing on an opponent, the attacker landed into the opponent's court in 11 of 12 situations compared to 2 situations for the blocker. When landing on another player, the ankle moved into a neutral dorsiflexed position prior to rapid pronation/supination in 15 situations compared to 1 situation of supination in plantarflexion. Conclusions The majority of injuries occur while blocking, often landing on an opponent. The attacker is responsible for injuries at the net secondary to crossing the center line. Landing-related injuries mostly occur with the ankle rapidly supinating in a neutral dorsiflexed position.
Changes in the Adrenal Glands of Rats Following Exposure to Lowered Oxygen Tension
Authors: Albert J. Dalton, Ellis R. Mitchell, Benjamin F. Jones, Virginia B. Peters
Journal: JNCI Journal of the National Cancer Institute (1944)

Changes in the Adrenal Glands of Rats Following Exposure to Lowered Oxygen Tension Get access Albert J. Dalton, Albert J. Dalton cytologist National Cancer Institute and Industrial Research Laboratory, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Ellis R. Mitchell, Ellis R. Mitchell assistant chemist National Cancer Institute and Industrial Research Laboratory, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Benjamin F. Jones, Benjamin F. Jones surgeon National Cancer Institute and Industrial Research Laboratory, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia B. Peters Virginia B. Peters assistant scientific aide National Cancer Institute and Industrial Research Laboratory, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 5, April 1944, Pages 527–536, https://doi.org/10.1093/jnci/4.5.527 Published: 01 April 1944
Neoadjuvant imatinib in patients with locally advanced GIST in the prospective BFR14 trial
Authors: P. A. Cassier, A. A. Blesius, D. Perol, I. Ray-Coquard, A. Adenis, B. Bui, F. Bertucci, M. Rios, A. Le Cesne, J. Blay
Journal: Journal of Clinical Oncology (2009)

10551 Background: The role of surgery in the management of patients with advanced gastrointestinal stromal tumors (GIST) in the era of imatinib mesylate (IM) remains unknown. We sought to assess the outcome of patients with locally advanced primary GIST tumors without metastases treated with IM in the neoadjuvant setting within the prospective BFR14 phase III trial. Methods: The data base of the BFR14 trial was searched for patients with locally advanced disease and no metastases. Patients with recurrent disease were excluded. Results: Twenty five patients (9 females, 16 males) met these criteria. Twenty patients were PS 0 or 1, primary tumor sites were: small intestine (n=7), peritoneum (n=7), rectum (n=4), stomach (n=4), esophagus (n=2), and pelvis (n=1). Nine of the 25 patients underwent surgical resection of the primary tumor after a median of 7.3 (range 3.4–12.1) months of treatment with IM. There was a significant improvement in progression-free survival (PFS) for patient who underwent surgical resection versus those who did not: median PFS: 28.7 month vs 12.9 months respectively (p=0.0463) this benefit did not however translate into a significant benefit in overall survival (OS), although the trend favoured the resected group: median OS median not reached vs 29.4 months (p=0.0677). Conclusions: Surgery may increase progression-free survival in patients with locally advanced GIST who become resectable following treatment with IM. [Table: see text]
The SNP rs380390 of complement factor H gene is associated with the risk of lung cancer and interacts with ERCC6 SNP rs3793784
Authors: Xuemei Zhang, Yongli Guo, Jingsheng Tuo, Bridgett Green, Carolyn Wise, Susan Kadlubar, Fred F. Kadlubar, Dongxin Lin, Baitang Ning
Journal: Cancer Research (2008)

3125   Lung cancer is one of the most common cancers in the world and is a leading cause of cancer death in the United States. With a very poor 5-year survival rate ( ERCC6  contributes to lung cancer risk in a case control study. The same variant has a synergistic effect with a polymorphism of complement factor H (rs380390) on age-related macular degeneration predisposition. In the current study, we examined the contribution of the SNP rs380390 in the complement factor H gene ( CFH ) to the risk of lung cancer in a case-control study with 1,000 cases and 1,000 controls (age, gender and smoking status matched with cases) from Han Chinese. The case-control analysis revealed a 1.5-fold excess risk of developing lung cancer for the carriers of G allele compared with non-carriers. The  CFH  G allele interacts with smoking to intensify lung cancer risk, with the odds ratio (OR) = 6.39 for developing lung cancer among heavy smokers. Moreover, the  CHF  SNP rs380390 interacts with  ERCC6  SNP rs3793784 in a supermultiplicative joint manner to have a synergistic effect on lung cancer risk predisposition, with an odds ratio of 2.68.
The way we are using to improve the preoperative identification of pancreatic cystic neoplasms: 213 cases in a single Chinese pancreatic surgery center.
Authors: Hengchao Li, Ji Li, Xinzhe Yu, Xiaoyi Wang, Feng Yang, Lie Yao, Si Jie Hao, Yong Jian Jiang, Chen Jin, Deliang Fu
Journal: Journal of Clinical Oncology (2015)

e15266 Background: The preoperative identification of pancreatic cystic neoplasms (PCNs) is crucial to the surgical decision-making. Besides pursuing better imaging and laboratory techniques, this study aims to prove that the diagnostic accuracy can be improved via learning international consensus and adopting multidisciplinary team (MDT) modality. Methods: A total of 213 cases of PCNs were reviewed retrospectively from 1999 to 2013. The effect to the accuracy of preoperative identification was analyzed by using advanced diagnostic methods, which included imaging and laboratory approach, learning Sendai Consensus Guidelines (SCG), and adopting MDT clinical modality. Results: The overall preoperative diagnostic accuracy of PCNs was 60.6%. The highest was 93.8% for intraductal papillary mucinous neoplasms (IPMN) among all subtypes, followed by 75% for serous cystic neoplasms (SCN) and 71.4% for solid pseudopapillary neoplasms (SPN). The combination of contrast enhanced computed tomography (CECT)，endoscopic ultrasound (EUS) and magnetic resonance imaging/ cholangiopancreatography (MRI/MRCP) could significantly increase the overall accuracy to 83.3%. Meanwhile, learning SCG could raise the accuracy of PCNs from 47.4% to 50%, furthermore, the accuracy was significantly increased to 70.5% after establishing an MDT. Conclusions: In addition to the combined application of diagnostic techniques, the preoperative diagnostic accuracy of PCNs is significantly improved with increased subject awareness through the application of the SCG and the use of an MDT.
Liposome‐Indocyanine Green Nanoprobes for Optical Labeling and Tracking of Human Mesenchymal Stem Cells Post‐Transplantation In Vivo
Authors: Mariarosa Mazza, Neus Lozano, Debora Braga Vieira, Maurizio Buggio, Cay Kielty, Kostas Kostarelos
Journal: Advanced Healthcare Materials (2017)

Abstract Direct labeling of human mesenchymal stem cells (hMSC) prior to transplantation provides a means to track cells after administration and it is a powerful tool for the assessment of new cell‐based therapies. Biocompatible nanoprobes consisting of liposome‐indocyanine green hybrid vesicles (liposome‐ICG) are used to safely label hMSC. Labeled hMSC recapitulating a 3D cellular environment is transplanted as spheroids subcutaneously and intracranially in athymic nude mice. Cells emit a strong NIR signal used for tracking post‐transplantation with the IVIS imaging system up to 2 weeks (subcutaneous) and 1 week (intracranial). The transplanted stem cells are imaged in situ after engraftment deep in the brain up to 1 week in living animals using optical imaging techniques and without the need to genetically modify the cells. This method is proposed for efficient, nontoxic direct cell labeling for the preclinical assessment of cell‐based therapies and the design of clinical trials, and potentially for localization of the cell engraftment after transplantation into patients.