tbuckley/cabot-search huggingface dataset:
Abstract 19002: Predictive Value of the Intraoperative Pulmonary Artery Flow Study for Early and Late Outcome After Surgical Treatment of Pulmonary Atresia With Ventricular Septal Defect and Major Aortopulmonary Collateral Arteries (MAPCAs)
Authors: Matteo Trezzi, Antonio Albano, Sonia B Albanese, Enrico Cetrano, Adriano Carotti
Journal: Circulation (2015)

Introduction &amp; Hypothesis: 1. To evaluate the accuracy of the intraoperative pulmonary artery (PA) flow study in determining the feasibility of concomitant VSD closure after complete one-stage unifocalization in patients with pulmonary atresia with VSD and MAPCAs. 2. To determine the ability of the PA flow study to predict long-term outcomes. Methods: Between October 1996 and May 2015, a PA flow study was obtained in 92 patients undergoing complete one-stage unifocalization. The study was performed by cannulating the unifocalized central PA. With the heart beating, incremental volumes of blood were pumped through the PAs. The ability to achieve 100% flow (2.5 l/min/m 2 ) into the pulmonary bed at a mean pressure (mPAP) ≤ 30 mmHg was used as an indicator for acceptability of VSD closure. Results: Among the 92 patients who had a PA flow study, 23 had a mPAP &gt; 30 mmHg and the VSD was left open. VSD closure was performed in 69 patients (mPAP 24 ± 5 mmHg, range 11-34 mmHg). However, four (5.8%) required patch fenestration due to suprasystemic RV pressure. The recorded mPAPs of these 4 patients were 29, 24, 22 and 28 mmHg, respectively. In the whole cohort, median weight at operation was 7.9 kg (range, 2.5-54 kg). The PA flow study accurately predicted successful VSD closure (area under the curve 0.852, Figure 1A). VSD closure at the time of unifocalization resulted in a clear survival advantage (p = 0.0363). mPAP correlated with RVP to LVP ratio (rho 0.460, p = 0.0001) and better long-term results were observed with intraoperative mPAP ≤ 30 mmHg (p = 0.24, Figure 1B). Conclusions: Successful VSD closure in patients with MAPCAs can be reliably defined by an intraoperative PA flow study with a cut-off of 30 mmHg. The PA flow study predictive value is particularly useful to select patients in which the VSD should be left open. mPAP strongly correlates with the intraoperative RVP/LVP ratio and lower values of mPAP at the time of the unifocalization are associated with improved long-term outcomes.
Reaparición del tifus murino en Portugal
Authors: F Bacellar, I Lencastre, A R Filipe
Journal: Eurosurveillance (1998)

El tifus murino o tifus endemico es una enfermedad infecciosa, clinicamente muy parecida al tifus epidemico y causada por la Rickettsia typhi (tambien denominada R. mooseri).
Identification and Validation of a Salivary Protein Panel to Detect Heart Failure Early
Authors: Xi Zhang, Terry Walsh, John J Atherton, Karam Kostner, Benjamin Schulz, Chamindie Punyadeera
Journal: Theranostics (2017)

Background: Over 26 million people suffer from heart failure (HF) globally.Current diagnosis of HF relies on clinical evaluation, blood assays and imaging techniques.Our aim is to develop a diagnostic assay to detect HF in at risk individuals within the community using human saliva as a medium, potentially leading to a simple, safe early warning system.Methods: Saliva samples were collected from healthy controls (n=36) and HF patients (n=75).Salivary proteome profiles were analysed by Sequential Window Acquisition of All Theoretical fragment ion spectra -Mass Spectrometry (SWATH-MS).A total of 738 proteins were quantified and 177 proteins demonstrated significant differences between HF patients and healthy controls.Candidate biomarkers were chosen based on their abundance and difference between the two cohorts.A multi-protein panel was developed using logistic regression analysis.The diagnostic performance of the multi-protein panel was assessed using receiver operative characteristic curves.The candidate proteins were further confirmed, using western blot analysis, and validated technically, using an independent biological cohort.Results: A group of six proteins were chosen in the discovery phase as potential candidates based on their differences in the abundance between the two cohorts.During the validation phase, two of the proteins were not detected with western blotting and as such were removed.The final panel consists of four proteins with sensitivity of 83.3%, specificity of 62.5% with an area under ROC curve of 0.78 in discriminating healthy controls from NYHA class I/II HF patients, and was validated in a second independent cohort study.Conclusion: Analysis of salivary proteome using SWATH-MS revealed novel HF-specific protein candidates yielding high diagnostic performance.A multi-centre longitudinal clinical trial will be the next step before clinical implementation of this panel.
Genome-wide DNA methylation analysis reveals a prognostic classifier for non-metastatic colorectal cancer (ProMCol classifier)
Authors: Melanie Gündert, Dominic Edelmann, Axel Benner, Lina Jansen, Min Jia, Viola Walter, Phillip Knebel, Esther Herpel, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Barbara Burwinkel
Journal: Gut (2017)

Pathological staging used for the prediction of patient survival in colorectal cancer (CRC) provides only limited information.Here, a genome-wide study of DNA methylation was conducted for two cohorts of patients with non-metastatic CRC (screening cohort (n=572) and validation cohort (n=274)). A variable screening for prognostic CpG sites was performed in the screening cohort using marginal testing based on a Cox model and subsequent adjustment of the p-values via independent hypothesis weighting using the methylation difference between 34 pairs of tumour and normal mucosa tissue as auxiliary covariate. From the 1000 CpG sites with the smallest adjusted p-value, 20 CpG sites with the smallest Brier score for overall survival (OS) were selected. Applying principal component analysis, we derived a prognostic methylation-based classifier for patients with non-metastatic CRC (ProMCol classifier).This classifier was associated with OS in the screening (HR 0.51, 95% CI 0.41 to 0.63, p=6.2E-10) and the validation cohort (HR 0.61, 95% CI 0.45 to 0.82, p=0.001). The independent validation of the ProMCol classifier revealed a reduction of the prediction error for 3-year OS from 0.127, calculated only with standard clinical variables, to 0.120 combining the clinical variables with the classifier and for 4-year OS from 0.153 to 0.140. All results were confirmed for disease-specific survival.The ProMCol classifier could improve the prognostic accuracy for patients with non-metastatic CRC.
Factors Associated With Prevalence and Treatment of Primary Biliary Cholangitis in United States Health Systems
Authors: Mei Lu, Jia Li, Irina V. Haller, Robert J. Romanelli, Jeffrey J. VanWormer, Carla V. Rodriguez, Marsha A. Raebel, Joseph A. Boscarino, Mark A. Schmidt, Yihe G. Daida, Amandeep Sahota, Jennifer Vincent, Christopher L. Bowlus, Keith Lindor, Loralee B. Rupp, Stuart C. Gordon, Rene Everline, Zahra S. Daar, Christina Melkonian, Talan Zhang, Yueren Zhou, Hank Wu, Dana Larkin, Nishat Islam, Nonna Akkerman, Sheri Trudeau, Diane Kohnhorst, Sally F. Shaw, Vicki Chiu, Judy Donald, Michelle Turner, Kevin Rubenstein, Jacquelyn Redd, Carmen Wong, Joanne Mor, Kathy Bow, Lisa E. Pieper, Heather Anderson, Nathan Tesch, Solomon Trimble, Mario J. De Los Santos, Tina Amlin, Shamyal Khan, Kevin Dunlap
Journal: Clinical Gastroenterology and Hepatology (2017)
Porque razão os adultos contraem difteria
Authors: J Tomaszunas-Blaszczyk, A Galazka
Journal: Eurosurveillance (1997)

Quando a difteria era uma doenca comum, afectava mais frequentemente as criancas. Tipicamente, pelo menos 40% dos casos de difteria eram em criancas com menos de 5 anos de idade e cerca de 70% dos casos eram em criancas com menos de 15 anos. Este padrao classico dos casos de difteria era visto em muitos paises incluindo os Estados Unidos (EUA) entre 1908 e 1934 (1), Alemanha entre 1929 e 1931 (2), e Inglaterra e Gales entre 1936 e 1937 (3).
Donor lymphocyte infusion and methotrexate for immune recovery after T‐cell depleted haploidentical transplantation
Authors: Andrew L. Gilman, Wing Leung, Morton J. Cowan, Mark Cannon, Stacy Epstein, Carrie Barnhart, Krishna Shah, Michelle Hyland, Tracy Fukes, Anastasia Ivanova
Journal: American Journal of Hematology (2017)

Abstract CD34+ cell selection minimizes graft‐versus‐host disease (GVHD) after haploidentical donor stem cell transplant but is associated with slow immune recovery and infections. We report a Phase I/II study of prophylactic donor lymphocyte infusion (DLI) followed by methotrexate (MTX) GVHD prophylaxis after CD34‐selected haploidentical donor transplant. A prophylactic DLI was given between day +30 and +42. Rituximab was given with DLI for the last 10 patients. The goal of the study was to determine a DLI dose that would result in a CD4+ cell count &gt; 100/µL at Day +120 in ≥ 66% of patients with ≤ 33% grade II‐III, ≤ 17% grade III, and no grade IV acute GVHD by Day +180. Thirty‐five patients with malignant ( n = 25) or nonmalignant disease ( n = 10) were treated after CD34‐selected haploidentical donor peripheral blood stem cell transplant. The DLI dose of 5 × 10 4 /kg met the CD4/GVHD goal with 67% of patients having CD4+ cells &gt; 100/µL and 11% grade II‐IV acute GVHD. The cumulative incidence of chronic GVHD was 16%. Fatal viral and fungal infections occurred in 11%. The 2 year estimated overall survival was 69% and the relapse rate was 14% for patients in remission at transplant. There was no effect of NK alloreactivity on relapse. Nine of ten patients at the target DLI dose cohort of 5 × 10 4 /kg are alive with median follow‐up of 18 mos (range 6‐29). Delayed prophylactic DLI and MTX was associated with promising outcomes at the target DLI dose. This trial was registered at clinicaltrials.gov , # NCT01027702.
El Informe Europeo de la OMS confirma la relación entre el desarrollo socioeconómico y la salud
Authors: M. S. Vilayleck
Journal: Eurosurveillance (2002)

Mas de 300 delegados, incluyendo 20 ministros de sanidad, participaron en la 52o sesion del Comite Regional para Europa de la Organizacion Mundial de la Salud (OMS), celebrada en Copenhague (Dinamarca) del 16 al 19 de septiembre. En esta ocasion, se dio a conocer el Informe Sanitario Europeo 2002. Este informe confirma la estrecha relacion que existe entre el desarrollo socioeconomico, la salud y la equidad en la Region Europea de la OMS que abarca 51 Estados Miembros de la OMS y cuenta con unos 870 millones de personas. Si bien los niveles generales de sanidad en la Region son de los mas elevados del mundo, el informe describe una distancia creciente entre paises e incluso dentro de ellos (www.euro.who.int/europeanhealthreport).
AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses
Authors: Marijn A. Gillissen, Martijn Kedde, Greta de Jong, Gemma Moiset, Etsuko Yasuda, Sophie E. Levie, Arjen Q. Bakker, Yvonne B. Claassen, Koen Wagner, Martino Böhne, Paul J. Hensbergen, Dave Speijer, Pauline M. van Helden, Tim Beaumont, Hergen Spits, Mette D. Hazenberg
Journal: Blood (2017)
Feasibility and safety of nerve stimulator attachment to energy-based devices: A porcine model study
Authors: Sung-Chan Shin, Eui-Suk Sung, Sung-Won Choi, Sung-Dong Kim, Da-Woon Jung, Seok-Hyun Kim, Jung Hoon Ro, Jin-Choon Lee, Byung-Joo Lee
Journal: International Journal of Surgery (2017)
Reporting Deaths Among Children Aged &lt;5 Years After the Ebola Virus Disease Epidemic — Bombali District, Sierra Leone, 2015–2016
Authors: Amanda L. Wilkinson, Reinhard Kaiser, Mohamed F. Jalloh, Mamudi Kamara, Dianna M. Blau, Pratima L. Raghunathan, Alpha Kamara, Umaru Kamara, Nathaniel Houston-Suluku, Kevin Clarke, Amara Jambai, John T. Redd, Sara Hersey, Brima Osaio-Kamara
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Mortality surveillance and vital registration are limited in Sierra Leone, a country with one of the highest mortality rates among children aged <5 years worldwide, approximately 120 deaths per 1,000 live births (1,2). To inform efforts to strengthen surveillance, stillbirths and deaths in children aged <5 years from multiple surveillance streams in Bombali Sebora chiefdom were retrospectively reviewed. In total, during January 2015-November 2016, 930 deaths in children aged <5 years were identified, representing 73.3% of the 1,269 deaths that were expected based on modeled estimates. The "117" telephone alert system established during the Ebola virus disease (Ebola) epidemic captured 683 (73.4%) of all reported deaths in children aged <5 years, and was the predominant reporting source for stillbirths (n = 172). In the absence of complete vital events registration, 117 call alerts markedly improved the completeness of reporting of stillbirths and deaths in children aged <5 years.
Vigilancia de las infecciones de transmisión sexual en Inglaterra y Gales
Authors: G Hughes, T Paine, D Thomas
Journal: Eurosurveillance (1998)

La vigilancia de las infecciones de transmision sexual (ITS) en Inglaterra y Gales se ha basado, sobre todo en el pasado, en datos estadisticos globales que las clinicas antivenereas remitian al Centro de Vigilancia de Enfermedades Transmisibles (Communicable Disease Surveillance Centre; CDSC), asi como en diversos sistemas de notificacion de los laboratorios. Aunque estos sistemas ofrecen datos de vigilancia relativamente fiables, no proporcionan suficiente informacion sobre factores de riesgo como para conducir adecuadamente los programas de control y prevencion de las ITS. En los ultimos anos, el considerable aumento de las ITS, la aparicion de numerosos brotes de estas enfermedades y los cambios registrados en los patrones de resistencia gonococica han hecho necesario introducir unos procedimientos de vigilancia mas complejos. Este articulo describe los sistemas de vigilancia de las ITS actualmente vigentes en Inglaterra y Gales, incluidos los sistemas de reciente implantacion o en proceso de desarrollo, que cubren la necesidad de obtener unos datos de vigilancia mas detallados de las ITS.
TCT-830 Outcomes of Patients With Elevated vs. Normal B-Type Natriuretic Peptides After Intervention for Left Main Coronary Artery Disease
Authors: Bjorn Redfors, Shmuel Chen, Aaron Crowley, Ori Ben-Yehuda, Bernard Gersh, Nicholas Lembo, William Brown, Adrian Banning, Patrick Serruys, A. Pieter Kappetein, Joseph Sabik, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
Comment on Lachin et al. Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial. Diabetes Care 2017;40:777–783
Authors: Jesper Fleischer, Simon Lebech Cichosz, Troels Krarup Hansen
Journal: Diabetes Care (2017)

Inspired by the interesting study from Lachin et al. (1), we performed post hoc analyses of existing data from two of our recent clinical studies (2,3) to investigate the possible association between the glycemic variability parameter mean amplitude of glycemic excursions (MAGE) calculated from either self-monitoring of blood glucose (SMBG) or continuous glucose monitoring (CGM) devices. In both studies, all patients were equipped with a CGM device and instructed to perform SMBG measurements for 3 days in a row. In the first study (2), 21 patients with type 1 diabetes performed seven blood glucose measurements each day. Our post hoc analysis showed no correlation between MAGESMBG and MAGECGM, R 2 = …
Fortalecimento da função de advertência de vigilância precoce na República da Sérvia: lições aprendidas ao fim de um ano de implementação
Authors: M Valenciano, I Bergeri, D Jankovic, N Milic, M Parlic, D Coulombier
Journal: Eurosurveillance (2004)

A Republica da Servia, com apoio da OMS, implementou um sistema de advertencia precoce (ALERT) para doencas transmissiveis prioritarias, para complementar o sistema de vigilância de rotina que notifica casos confirmados individuais. Sao aqui apresentados os resultados da sua avaliacao, efectuada um ano depois da implementacao. O ALERT assenta na notificacao de 11 sindromes por parte de instituicoes de cuidados primarios. Os dados sao analisados semanalmente a nivel distrital e transmitidos a epidemiologistas nacionais. O ALERT e entendido como uma ferramenta simples e flexivel. A aceitabilidade e mais elevada a nivel nacional do que a nivel distrital. Alguns distritos entendem o ALERT como um sistema paralelo, deficientemente ligado a medidas de controlo. A sensibilidade do ALERT para detectar casos de meningite e de 93%, sendo de 37% para casos de hepatite. A analise retrospectiva dos dados do ALERT identificou 9 epidemias, das quais 5 tinham sido reconhecidas peloso epidemiologistas. O ALERT revelou-se como o sistema mais atempado para detectar 4 epidemias identificadas pelos dois sistemas. O ALERT foi util para desencadear uma investigacao e controlo atempados de epidemias de hantavirus e salmonelose e para detectar o inicio da epoca da gripe. Todavia, o ALERT nao detectou casos agrupados de brucelose e tularemia responsaveis pelo sindrome de febre inexplicada. Esta avaliacao sublinhou a necessidade de uma revisao global das actividades de vigilância quando se implementam novos componentes, como o ALERT. Embora as medidas de controlo baseadas na notificacao de casos confirmados individuais esteja bem compreendida e implementada, o processo de investigacao e verificacao que deveriam resultar de um aumento dos sindromes ALERT nao se encontra totalmente compreendido. Para efectivar esta alteracao de perspectiva, serao uteis programas de formacao em epidemiologia de campo, como o programa EPIET.
Le contrôle de la rubéole en Italie
Authors: M L Ciofi Degli Atti, A Filia, M G Revello, W Buffolano, S Salmaso
Journal: Eurosurveillance (2004)

En Italie, la vaccination contre la rubeole est recommandee depuis 1972 pour les jeunes filles pre-puberes et depuis le debut des annees 1990, pour tous les enfants au cours de leur deuxieme annee. Cependant, la couverture vaccinale des enfants de 12 a 24 mois reste sub-optimale (56% en 1998, 78% en 2003), avec d'importantes variations selon les regions. 
De ce fait, la rubeole continue a circuler dans le pays, et en 1996 la proportion de femmes de 15 a 39 ans susceptibles a la rubeole etait superieure a 5%. 
Entre 1987 et 1991, le syndrome de la rubeole congenitale (SRC) etait une maladie a declaration et le nombre annuel de cas declares allait de 8 a 76. Depuis 1992, les donnees d'incidence nationale ne sont plus disponibles, mais des rapports au niveau local montrent la presence de cas de SRC. 
A l'echelle nationale, lutter efficacement contre le SRC necessite des actions coordonnees. C'est a cette fin que Le Plan national d'eradication de la rougeole et de la rubeole congenitale a ete lance recemment. Ce plan comprend des actions dont l'objectif est d'augmenter la couverture vaccinale du ROR chez les enfants ainsi que des mesures specifiques pour lutter contre la rubeole congenitale, telles que l'amelioration de la vaccination chez les femmes susceptibles en âge de procreer et la reintroduction d'une surveillance nationale du SRC.
Multiple mechanisms of Mcl-1 depletion by the cyclin-dependent kinase inhibitor flavopiridol in mantle cell lymphoma cell lines
Authors: Takeshi Shimamura, April M. Lowell, Susumu Kobayashi, Daniel G. Tenen, Geoffrey I. Shapiro
Journal: Cancer Research (2006)

2085  Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma carrying poor prognosis. The disease is characterized by the t(11;14) (q13;q32) chromosomal translocation and overexpression of cyclin D1, which drives cellular proliferation by stimulating the activity of cyclin-dependent kinases (cdks) 4 and 6. Overexpression of anti-apoptotic proteins, most notably Mcl-1, is an additional hallmark of MCL cells. The pan-cyclin-dependent kinase inhibitor flavopiridol has demonstrated responses in MCL patients, even when suboptimal schedules have been employed. Flavopiridol most potently inhibits cdk9, with Ki 3 nM, and its effects on cellular transcription are expected to compromise Mcl-1 expression. Preclinical studies of flavopiridol in Z138-C, NCEB-1, Granta 519, and JVM-2 MCL cell lines were performed to elucidate mechanisms of cell death. Z138-C cells were the most sensitive with IC50 around 100nM. Growth of Granta 519 was compromised above 200nM drug, while NCEB-1 and JVM-2, which express the highest levels of Mcl-1, were relatively resistant. Time course experiments in Z138-C cells treated with 200-500 nM flavopiridol demonstrated that reduction of phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNA pol II) occurred by 8 hrs after drug exposure, likely related to cdk9 inhibition. Depletion of cyclin D1 and phospho-Rb occurred a few hours later. Surprisingly, reduction in Mcl-1 expression was noted by 3-4 hours, prior to altered phosphorylation of the RNA pol II CTD. In addition, the appearance of cleaved PARP, indicative of apoptosis, preceded the reduction of phospho-CTD and cyclin D1 and closely paralleled the diminution of Mcl-1. To better explain the early diminution of Mcl-1 expression, we investigated signaling pathways known to contribute to its stability. The data show that flavopiridol causes reduction in both phospho-Erk and phospho-Akt by 2 hrs after drug exposure, directly preceding the diminution of Mcl-1. In addition, the efficacy of flavopiridol against MCL cell lines was synergistically enhanced by co-treatment with agents that modulate the Akt pathway, including the PI3-K inhibitor LY294002, as well as rapamycin, an mTOR inhibitor. However, in cells treated with flavopiridol alone, there is recovery of these pathways within 4-5 hours. These results suggest that Mcl-1 expression is tightly linked to apoptosis in flavopiridol-treated MCL cell lines and that early effects on signaling pathways correlate best with the timing of initial Mc1-reduction. Later, reduced phosphorylation of the RNA pol II CTD may prevent further Mcl-1 expression and reduction of cyclin D1 expression as well. Therefore, flavopiridol-mediated depletion of Mcl-1 occurs by multiple mechanisms. These preclinical results justify further trials of flavopiridol in MCL both alone and in combination.
TCT-306 Transcatheter Aortic Valve Replacement with Extremely Large Annuli Greater Than 683 mm2 Using Edwards Sapien 3 Valve – A Multicenter Experience
Authors: Gilbert Tang, Syed Zaid, Isaac George, Omar Khalique, Yigal Abramowitz, Raj Makkar, Hasan Jilaihawi, Norihiko Kamioka, Vinod Thourani, Vasilis Babaliaros, Hasan Ahmad, John Webb, Nay Htun, Nimesh Desai, K. Sharma, Saif Anwaruddins, Wilson Y. Szeto, Howard Herrmann, Sukhdeep Basra, Molly Szerlip, Michael Mack, Rahul Sharma, Sameer Gafoor, Ming Zhang, Stephanie Mick, Amar Krishnaswamy, Arash Salemi, Annapoorna Kini, Josep Rodés-Cabau, Martin Leon, Susheel Kodali
Journal: Journal of the American College of Cardiology (2017)