tbuckley/cabot-search huggingface dataset:
Validation Study of the American Joint Committee on Cancer Eighth Edition Prognostic Stage Compared With the Anatomic Stage in Breast Cancer
Authors: Anna Weiss, Mariana Chavez-MacGregor, Daphne Y. Lichtensztajn, Min Yi, Audree Tadros, Gabriel N. Hortobagyi, Sharon H. Giordano, Kelly K. Hunt, Elizabeth A. Mittendorf
Journal: JAMA Oncology (2017)

<h3>Importance</h3> The American Joint Committee on Cancer (AJCC) eighth edition staging manual introduced a new prognostic stage for breast cancer incorporating biologic factors in addition to traditional anatomic factors. <h3>Objective</h3> To perform a validation study of the AJCC eighth edition prognostic stage in a single-institution cohort and a large population database. <h3>Design, Setting, and Participants</h3> Patients with breast cancer treated with surgery as an initial intervention were identified in a prospective institutional database from The University of Texas MD Anderson Cancer Center and the California Cancer Registry. Vital status data were complete through December 31, 2016, in The University of Texas MD Anderson cohort and through December 31, 2014, in the California Cancer Registry cohort. Patients receiving neoadjuvant systemic therapy, those with inflammatory or rare breast cancers, and those with unknown clinicopathologic factors were excluded. Factors evaluated included T, N, and M categories and tumor grade, as well as estrogen receptor, progesterone receptor, and HER2 status. <h3>Main Outcomes and Measures</h3> Disease-specific survival was calculated by the Kaplan-Meier method. The Harrell concordance index (C index) was used to quantify models' predictive performance, and the Akaike information criterion (AIC) was used to compare model fits. <h3>Results</h3> A total of 3327 patients with stage I to IIIC breast cancer treated between 2007 and 2013 at The University of Texas MD Anderson Cancer Center (median follow-up of 5 years) with complete clinicopathologic data were identified. Compared with the AJCC anatomic stage, the prognostic stage upstaged 29.5% of patients and downstaged 28.1%. The prognostic stage (C index, 0.8357 and AIC, 816.8) provided more accurate stratification with respect to disease-specific survival than the anatomic stage (C index, 0.737 and AIC, 1039.8) (<i>P</i> &lt; .001 for the C index). A total of 54 727 patients with stage I to IV breast cancer treated between 2005 and 2009 were identified in the California Cancer Registry (median follow-up of 7 years). The prognostic stage upstaged 31.0% of patients and downstaged 20.6%. The prognostic stage (C index, 0.8426 and AIC, 80 661.68) performed better than the anatomic stage (C index, 0.8097 and AIC, 81 577.89) (<i>P</i> &lt; .001 for the C index). <h3>Conclusions and Relevance</h3> The prognostic stage provided more accurate prognostic information than the anatomic stage alone in both a single-institution cohort and a large population database, thereby supporting its use in breast cancer staging.
Corn Harvest Along the Brandywine
Authors: Frederick Butzen
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17785: Impaired Subendocardial Contractility and Longitudinal Shortening With Aging, Reduce Midwall Fiber Stress, Increasing Circumferential Shortening and Preserving Ejection Fraction
Authors: Espen W Remme, Otto A Smiseth
Journal: Circulation (2016)

Introduction:  Left ventricular (LV) longitudinal function declines with age, potentially due to subclinical pathological development of fibrosis and reduced perfusion in the subendocardial region. On the other hand, radial function is increased, thus preserving ejection fraction (EF). The mechanism of compensatory increased radial function is not fully understood.   Hypothesis:  Impaired contractility in the subendocardium with predominantly longitudinal fibers, reduces longitudinal shortening but also reduces systolic midwall fiber stress. This reduced “afterload” of the predominantly circumferentially oriented midwall fibers, increases circumferential shortening which preserves EF.   Methods:  We applied a finite element model of the LV which included nonlinear, transversely isotropic passive elastic myocardial properties, active fiber tension prescribed as a function of time and fiber length, and the anatomical transmural change in fiber orientation from endocardium to epicardium. Simulations of the cardiac cycle were performed; first with homogenous contractility and then with reduced contractility in the subendocardial region. We assessed changes in EF, peak systolic pressure, global longitudinal strain (GLS), global circumferential strain (GCS), and fiber stress.   Results:  Reduced subendocardial contractility decreased longitudinal shortening (Figure), while circumferential shortening increased. There was practically no change in EF. Peak systolic pressure was moderately reduced. In the midwall, systolic fiber stress was reduced.   Conclusions:  Reduced contractility in the subendocardium, reduces longitudinal shortening, but also reduces midwall circumferential fiber stress which seems to promote compensatory increased circumferential shortening that maintains EF. This mechanism may be one explanation for the observed changes in myocardial strains during aging.
<i>Atopobium</i> and <i>Fusobacterium</i> as novel candidates for sarcoidosis-associated microbiota
Authors: Alexandra Zimmermann, Henrik Knecht, Robert Häsler, Gernot Zissel, Karoline I. Gaede, Sylvia Hofmann, Almut Nebel, Joachim Müller-Quernheim, Stefan Schreiber, Annegret Fischer
Journal: European Respiratory Journal (2017)

Sarcoidosis is a granulomatous disease that mainly affects the lung. A role of microbial factors in disease pathogenesis is assumed, but has not been investigated systematically in a large cohort. This cross-sectional study compared the lung microbiota of 71 patients with sarcoidosis, 15 patients with idiopathic pulmonary fibrosis (non-infectious controls) and 10 healthy controls (HCs). Next-generation sequencing of 16S DNA was used on bronchoalveolar lavage samples to characterise the microbial composition, which was analysed for diversity and indicator species. Host genotypes for 13 known sarcoidosis risk variants were determined and correlated with microbial parameters. The microbial composition differed significantly between sarcoidosis and HC samples (redundancy analysis ANOVA, p=0.025) and between radiographic Scadding types. Atopobium spp. was detected in 68% of sarcoidosis samples, but not in HC samples. Fusobacterium spp. was significantly more abundant in sarcoidosis samples compared with those from HCs. Mycobacteria were found in two of 71 sarcoidosis samples. Host-genotype analysis revealed an association of the rs2076530 ( BTNL2 ) risk allele with a decrease in bacterial burden (p=0.002). Our results indicate Scadding type-dependent microbiota in sarcoidosis BAL samples. Atopobium spp. and Fusobacterium spp. were identified as sarcoidosis-associated bacteria, which may enable new insights into the pathogenesis and treatment of the disease.
Abstract 34: Wee1 inhibition sensitizes tumor cells with variable antigenicity to T cell mediated lysis
Authors: Ellen Moore, Lillian Sun, Jay Friedman, Carter Van Waes, Clint Allen
Journal: Clinical Cancer Research (2017)

Abstract Antigen-specific elimination of tumor cells by cytotoxic T-lymphocytes (CTL) inherently relies upon the sensitivity of target cells to effector products such as granzyme B, TNFa, TNF-related apoptosis-inducing ligand (TRAIL), and Fas ligand (FasL). Cell cycle progression is critically required for granzyme B and TNF superfamily-induced apoptosis. Thus, we hypothesized that inhibition of Wee1 with AZD1775 would release the G2/M cell cycle checkpoint and enhance sensitivity of oral cavity cancer cells to CTL killing. To explore this hypothesis, we stably transduced murine oral cancer 1 (MOC1) cells with a construct encoding the fluorescent protein mKate2 and SIINFEKL, the H2-Kb-restricted epitope of ovalbumin (MOC1mK2SIIN). Using in-vitro generated SIINFEKL-specific OT-1 CTLs as effectors, we demonstrated in a real-time, impedance-based assay of cytotoxicity that physiologic concentrations of AZD1775 (250 nM) significantly sensitized MOC1mK2SIIN cells to CTL killing at low E:T ratios. The same concentration of AZD1775 had negligible effects on the MOC1mK2SIIN cells alone, and OT-1 CTL cytotoxicity was antigen-specific as OT-1 effectors did not kill parental MOC1 cells with or without AZD1775 treatment. This effect was partially reversed with the perforin inhibitor concanamycin A, implicating involvement of granzyme B. Further, by mixing MOC1mK2SIIN and parental MOC1 cells, we could alter the ratio of antigen clonality present within the target cell population. Inhibition of Wee1 with AZD1775 significantly enhanced OT-1 CTL control of target cell populations where 5, 10, 15, 20, 25, and 50% lack SIINFEKL antigen. Treatment of MOC1mK2SIIN and parental MOC1 cells with recombinant TNFa, TRAIL and FasL with and without AZD1775 confirmed enhanced TNF superfamily-induced tumor cell control following Wee1 inhibition. These data suggest that Wee1 inhibition broadly sensitizes antigen positive and negative cells to CTL effector products and that AZD1775 may induce “bystander killing” of antigen negative cells in target cell populations with mixed antigenicity. Experiments combining AZD1775 with immune-activating therapies in vivo are underway. Citation Format: Ellen Moore, Lillian Sun, Jay Friedman, Carter Van Waes, Clint Allen. Wee1 inhibition sensitizes tumor cells with variable antigenicity to T cell mediated lysis [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr 34.
Pathophysiologic Gut Hormone and Bile Acid Signalling After Oesophagectomy: Implications for Appetite, Postprandial Hypoglycaemia and Nutritional Status in Survivorship
Authors: J.A. Elliott, C.F. Murphy, N.G. Docherty, S.L. Doyle, A.L. Gallardo, C. Gahan, S. Joyce, N. Ravi, J.V. Reynolds, C.W. le Roux
Journal: International Journal of Surgery (2017)
Cost Sharing Does Not Lead to an Overall Increase of Involuntary Commitments in the Netherlands
Authors: André I. Wierdsma, Cornelis L. Mulder
Journal: JAMA Psychiatry (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Evaluation the effect of Brucella abortus RB51 lipopolysaccharide as an adjuvant on the efficiency of HPV-16 L1 and HPV-16 E7 DNA vaccines in C57BL/6 mice
Authors: H. Soleimanjahi, M. Shirmohammadi, Z. Kianmehr, H. Karimi
Journal: Annals of Oncology (2017)
Interferon lambda 4 rs368234815 TT&gt;δG variant is associated with liver damage in patients with nonalcoholic fatty liver disease
Authors: Salvatore Petta, Luca Valenti, Antonino Tuttolomondo, Paola Dongiovanni, Rosaria Maria Pipitone, Calogero Cammà, Daniela Cabibi, Vito Di Marco, Anna Ludovica Fracanzani, Sara Badiali, Valerio Nobili, Silvia Fargion, Stefania Grimaudo, Antonio Craxì
Journal: Hepatology (2017)

The interferon (IFN) lambda 3/4 (IFNL3/4) locus, influencing innate immunity regulation, has been associated with the severity of hepatitis and fibrosis progression during chronic hepatitis C infection, while contrasting results were reported in nonalcoholic fatty liver disease. In this study, we examined whether rs12979860 and the linked causal rs368234815 variant encoding for the alternative IFNL4 protein variant are associated with liver fibrosis and damage in a large multicenter cohort of patients at risk of nonalcoholic steatohepatitis. To clarify the mechanism, we also evaluated the impact on IFN-stimulated gene hepatic expression in a subset of patients. We considered 946 consecutive Italian individuals at risk of nonalcoholic steatohepatitis with liver histology evaluated according to Kleiner. The rs368234815 TT>δG, rs12979860 C>T, and patatin-like phospholipase-3 rs738409 C>G polymorphisms were genotyped; and IFN-stimulated gene hepatic expression (n = 16) was tested by TaqMan assays. We found that the rs368234815 TT allele was independently associated with severe F3-F4 fibrosis (odds ratio, 1.53; 95% confidence interval, 1.15-2.31; P = 0.005) and with severe (grade 2-3) lobular necroinflammation (odds ratio, 1.47; 95% confidence interval, 1.14-1.88; P = 0.002). The impact of rs368234815 on liver damage was generally more marked in nonobese individuals, where association with severe fibrosis, necroinflammation, and nonalcoholic steatohepatitis was observed (P < 0.05). IFN-stimulated genes were hypo-expressed in the liver of patients carrying the IFNL4 rs368234815 TT/TT genotype (P < 0.05). Similar results were observed when considering the rs12979860 polymorphism, which was in high linkage disequilibrium with rs368234815 (R2 = 0.87).The IFNL4 genotype is associated with severity of fibrosis in nonalcoholic fatty liver disease patients of European ancestry, likely by modulating the activation of innate immunity and necroinflammation. (Hepatology 2017;66:1885-1893).
A Scoring System to Drive Diagnosis and Management of Diseases Underliying Refractory Autoimmune Cytopenia
Authors: Francesca Fioredda, Andrea Todiere, Elena Palmisani, Michaela Calvillo, Francesca Riccardi, Paola Terranova, Filomena Pierri, Concetta Micalizzi, Carlo Dufour, Maurizio Miano
Journal: Blood (2016)
Targeting CDK6 and BCL2 Exploits the “MYB Addiction” of Ph+ Acute Lymphoblastic Leukemia
Authors: Marco De Dominici, Patrizia Porazzi, Angela Rachele Soliera, Samanta A. Mariani, Sankar Addya, Paolo Fortina, Luke F. Peterson, Orietta Spinelli, Alessandro Rambaldi, Giovanni Martinelli, Anna Ferrari, Ilaria Iacobucci, Bruno Calabretta
Journal: Cancer Research (2017)

Abstract Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) is currently treated with BCR-ABL1 tyrosine kinase inhibitors (TKI) in combination with chemotherapy. However, most patients develop resistance to TKI through BCR-ABL1–dependent and –independent mechanisms. Newly developed TKI can target Ph+ ALL cells with BCR-ABL1–dependent resistance; however, overcoming BCR-ABL1–independent mechanisms of resistance remains challenging because transcription factors, which are difficult to inhibit, are often involved. We show here that (i) the growth of Ph+ ALL cell lines and primary cells is highly dependent on MYB-mediated transcriptional upregulation of CDK6, cyclin D3, and BCL2, and (ii) restoring their expression in MYB-silenced Ph+ ALL cells rescues their impaired proliferation and survival. Levels of MYB and CDK6 were highly correlated in adult Ph+ ALL (P = 0.00008). Moreover, Ph+ ALL cells exhibited a specific requirement for CDK6 but not CDK4 expression, most likely because, in these cells, CDK6 was predominantly localized in the nucleus, whereas CDK4 was almost exclusively cytoplasmic. Consistent with their essential role in Ph+ ALL, pharmacologic inhibition of CDK6 and BCL2 markedly suppressed proliferation, colony formation, and survival of Ph+ ALL cells ex vivo and in mice. In summary, these findings provide a proof-of-principle, rational strategy to target the MYB "addiction" of Ph+ ALL. Significance: MYB blockade can suppress Philadelphia chromosome-positive leukemia in mice, suggesting that this therapeutic strategy may be useful in patients who develop resistance to imatinib and other TKIs used to treat this disease. Cancer Res; 78(4); 1097–109. ©2017 AACR.
Dyspnea in a Young Man
Authors: Mahmoud Abdelghany, Arbind Chaudhary, Sakti Mookherjee
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Association of wheeze with lung function decline in children with sickle cell disease
Authors: Glenda N. Bendiak, Dimas Mateos-Corral, Anwar Sallam, Eshetu G. Atenafu, Melanie Kirby, Isaac Odame, Peter Bikangaga, Padmaja Subbarao, Hartmut Grasemann
Journal: European Respiratory Journal (2017)

Emerging evidence suggests that wheezing in children with sickle cell disease (SCD) is associated with higher rates of acute chest syndrome (ACS) and vaso-occlusive crises, independent of a diagnosis of asthma [1, 2]. We investigated the relationships of longitudinal pulmonary function decline with wheeze, asthma and atopy in a cohort of paediatric patients with SCD, using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire [3], skin prick testing (SPT) and airway nitric oxide (NO) measurements. Wheeze in children with sickle cell disease is associated with airflow limitation and lung function decline <http://ow.ly/oyZQ30fXnQs> We thank the Brampton SCD Family Group for their help publicising the project, Lani Lieberman for her assistance in designing the protocol, Edwin Ho for assistance in data entry and the Paediatric Consultants at the Hospital for Sick Children for providing funding for the study.
Abstract 18725: Endovascular Aneurysm Repair Increases Aortic Stiffness
Authors: Tohru Takaseya, Seiji Onitsuka, Hiroyuki Otsuka, Hiroyuki Tanaka, Hiroki Aoki, Hisashi Kai
Journal: Circulation (2017)

Introduction: Endovascular aneurysm repair (EVAR) is considered as the predominant treatment for abdominal aortic aneurysms (AAA). Cardiovascular mortality remains the main cause of death among AAA...
Abstract 14947: Upregulation of Drp1 Receptor Proteins MiD49 and MiD51 by miR-34a-3p Increases Mitochondrial Fission and Cell Proliferation in Pulmonary Arterial Hypertension: Therapeutic Implications
Authors: Asish Dasgupta, Kuang-Hueih Chen, Jennifer Fu, Jeffrey Mewburn, Stephen L Archer
Journal: Circulation (2016)

Introduction: The obstructive vasculopathy in pulmonary arterial hypertension (PAH) is characterized by hyperproliferation and apoptosis-resistance of pulmonary artery smooth muscle cells (PASMC). ...
Abstract 14599: Selected Types of Exercise Improve BMI z-score in Overweight and Obese Children and Adolescents: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Authors: George A Kelley, Kristi S Kelley
Journal: Circulation (2016)

Introduction: The effect of selected types of exercise on BMI z-score in overweight and obese children and adolescents has not been established. Hypothesis: Exercise (aerobic and/or strength) impro...
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
Authors: Jie Wu, Hedong Zhang, Xiaomin Shi, Xiang Xiao, Yihui Fan, Laurie J. Minze, Jin Wang, Rafik M. Ghobrial, Jiahong Xia, Roger Sciammas, Xian C. Li, Wenhao Chen
Journal: Immunity (2017)
Aryl Hydrocarbon Receptor Antagonists Expand Adult Hematopoietic Stem Cells from Mobilized Peripheral Blood and Bone Marrow and Increase the Dose of CRISPR/Cas9 Gene-Edited NSG-Repopulating Cells
Authors: Megan D. Hoban, Kevin A. Goncalves, Jennifer L. Proctor, Hillary L. Adams, Sharon L. Hyzy, Katia S. George, Anthony E. Boitano, Michael P. Cooke
Journal: Blood (2017)