tbuckley/cabot-search huggingface dataset:
Increase in Endovascular Therapy in Get With The Guidelines-Stroke After the Publication of Pivotal Trials
Authors: Eric E. Smith, Jeffrey L. Saver, Margueritte Cox, Li Liang, Roland Matsouaka, Ying Xian, Deepak L. Bhatt, Gregg C. Fonarow, Lee H. Schwamm
Journal: Circulation (2017)

Background: Beginning in December 2014, a series of pivotal trials showed that endovascular thrombectomy (EVT) was highly effective, prompting calls to reorganize stroke systems of care. However, there are few data on how these trials influenced the frequency of EVT in clinical practice. We used data from the Get With The Guidelines-Stroke program to determine how the frequency of EVT changed in US practice. Methods: We analyzed prospectively collected data from a cohort of 2 437 975 patients with ischemic stroke admitted to 2222 participating hospitals between April 2003 and the third quarter of 2016. Weighted linear regression with 2 linear splines and a knot at January 2015 was used to compare the slope of the change in EVT use before and after the pivotal trials were published. Potentially eligible patients were defined as last known well to arrival time ≤4.5 hours and National Institutes of Health Stroke Scale score ≥6. Results: The frequency of EVT use was slowly increasing before January 2015 but then sharply accelerated thereafter. In the third quarter 2016, EVT was provided to 3.3% of all patients with ischemic stroke at all hospitals, representing 15.1% of all patients who were potentially eligible for EVT based on stroke duration and severity. At EVT-capable hospitals, 7.5% of all patients with ischemic stroke were treated in the third quarter of 2016, including 27.3% of the potentially eligible patients. From 2013 to 2016, case volumes nearly doubled at EVT-capable hospitals. Mean case volume per EVT-capable hospital was 37.6 per year in the last 4 quarters. EVT case volumes increased in nearly all US states from 2014 to the last 4 quarters, but with persistent geographic variation unexplained by differences in potential patient eligibility. Conclusions: EVT use is increasing rapidly; however, there are still opportunities to treat more patients. Reorganizing stroke systems to route patients to adequately resourced EVT-capable hospitals might increase treatment of eligible patients, improve outcomes, and reduce disparities.
Metabolism of Induced and Spontaneous Leukemias in Mice<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>
Authors: Dean Burk, Herbert Sprince, Juliet M. Spangler, Mary C. Boon, Jacob Furth
Journal: JNCI Journal of the National Cancer Institute (1942)

Journal Article Metabolism of Induced and Spontaneous Leukemias in Mice Get access Dean Burk, Dean Burk senior chemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Herbert Sprince, Herbert Sprince Parker research fellow Search for other works by this author on: Oxford Academic PubMed Google Scholar Juliet M. Spangler, Juliet M. Spangler research assistant Department of Biochemistry Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary C. Boon, Mary C. Boon research assistant Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacob Furth Jacob Furth associate professor of pathology Department of Pathology, Cornell University Medical College Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 3, Issue 3, December 1942, Pages 249–275, https://doi.org/10.1093/jnci/3.3.249 Published: 01 December 1942
Author’s reply: Estimation of the reproduction number for 2009 pandemic influenza A(H1N1) in the presence of imported cases
Authors: P M Kelly, G N Mercer, K Glass, S Paine
Journal: Eurosurveillance (2010)

Preview this article: Author’s reply: Estimation of the reproduction number for 2009 pandemic influenza A(H1N1) in the presence of imported cases, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/29/art19623-en-1.gif
La situation de la rougeole en Allemagne
Authors: E Gericke, Gernot Rasch, A Tischer, S Santibanez
Journal: Eurosurveillance (1997)

A la suite d'une reunion d'experts tenue a Copenhague les 19 et 20 novembre 1996 sur l'eradication de la rougeole en Europe, les pays europeens ont ete classes en quatre categories sur la base d'une etude recente menee par le bureau regional de l'OMS pour l'Europe (1). L'Allemagne se situait dans le troisieme groupe (tableau 1) comprenant les pays ou la rougeole est endemique, avec des foyers ou des vagues epidemiques importantes, et ou la surveillance n'est pas realisee systematiquement.
Thioaptamer targeted discoidal microparticles increase self immunity and reduce Mycobacterium tuberculosis burden in mice
Authors: Fransisca Leonard, Ngan P. Ha, Preeti Sule, Jenolyn F. Alexander, David E. Volk, Ganesh L.R. Lokesh, Xuewu Liu, Jeffrey D. Cirillo, David G. Gorenstein, Jinyun Yuan, Soumya Chatterjee, Edward A. Graviss, Biana Godin
Journal: Journal of Controlled Release (2017)
ESEN : uma comparação de programas de vacinação - Parte um: difteria
Authors: D Lévy-Bruhl, R G Pebody, I Veldhuijzen, M Valenciano, K Osborne
Journal: Eurosurveillance (1998)

O objectivo da Rede Europeia Sero-Epidemiologica (ESEN) e a coordenacao e harmonizacao da vigilância serologica da imunidade as doencas evitaveis pela vacinacao, em oito paises da Europa (Alemanha, Dinamarca, Franca, Finlândia, Holanda, Inglaterra, Italia e Suecia). Foi estabelecida em Marco de 1996, no âmbito do programa Biomed II, da Comunidade Europeia e e coordenada pelo Public Health Laboratory Service Communicable Disease Surveillance Centre (CDSC), em Londres.
Avelumab treatment in chemotherapy-naïve patients with distant metastatic Merkel cell carcinoma (mMCC)
Authors: S.P. D'Angelo, J. Russell, J. Hassel, C. Lebbé, B. Chmielowski, G. Rabinowits, P. Terheyden, I. Brownell, I. Zwiener, M. Bajars, M. Hennessy, H.L. Kaufman
Journal: Annals of Oncology (2017)
Response by Smolderen et al to Letter Regarding Article, “Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction: Insights From the TRIUMPH Registry (Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients’ Health Status)”
Authors: Kim G. E. Smolderen, Kensey G. Gosch, Donna M. Buchanan, John A. Spertus
Journal: Circulation (2017)
Exploring personalized immunotherapy opportunities in colorectal cancer
Authors: B. Navarro Rodrigo, S. Bobisse, S. Viganò, P. Baumgartner, T. Nguyen-Ngoc, P. Gannon, R. Genolet, B. Stevenson, C. Sempoux, M.-O. Sauvain, M. Hubner, D. Hahnloser, N. Demartines, M. Montemurro, L. Kandalaft, S. Rusakiewicz, A. Harari, G. Coukos
Journal: Annals of Oncology (2017)
Abstract 13495: Ambulatory Blood Pressure Characteristics and Long-Term Risk for Atrial Fibrillation
Authors: Juha Perkiomaki, Santeri Nortamo, Antti Ylitalo, Antero Kesäniemi, Olavi Ukkola, Heikki Huikuri
Journal: Circulation (2016)

Introduction: Data on the significance of different ambulatory blood pressure (ABP) characteristics in predicting long-term risk for atrial fibrillation (AF) are limited. Methods: Total of 903 subjects with or without hypertension aged from 40 to 59 years, who were recruited to the OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study, had ABP monitoring, underwent thorough clinical examinations and laboratory tests. Results: After an average 16.4 ± 3.6 years of follow-up, 91 (10%) of the study subjects had experienced a new-onset AF requiring a hospital visit. Of the components of baseline ABP, the night-time mean systolic blood pressure had the strongest univariate association with the occurrence of AF (120.8 ±15.9 vs. 116.4 ± 14.1 mmHg, p=0.005, in subjects with vs. without the occurrence AF). When the univariate predictors of AF, such as age, sex, body mass index, height, smoking history, alanine aminotransferase and uric acid, were entered in the multivariate Cox hazards model, age (HR=1.1, 95% CIs=1.06-1.15, p&lt;0.001) and body mass index (HR=1.06, 95% CIs=1.015-1.115, p=0.011) retained their significant predictive power. After adjustments in this clinical hazards model, the night-time mean systolic blood pressure still predicted the occurrence of AF (HR=1.014, 95% CIs=1.001-1.028, p=0.038). The blood pressure night-time dipping status was not associated with the occurrence of AF (p=0.41). Conclusion: Of the ABP characteristics, the night-time systolic blood pressure is a significant independent contributor to the long-term risk of new-onset AF.
A multicentre phase II trial addressing lenalidomide (LEN) maintenance in patients with relapsed diffuse large b-cell lymphoma (rDLBCL) who are not eligible for autologous stem cell transplantation (ASCT)
Authors: M. Sassone, F. Zaja, A. Re, M. Spina, A. Di Rocco, A. Fabbri, C. Stelitano, M. Frezzato, C. Rusconi, R. Zambello, T. Calimeri, L. Scarfò, C. Cecchetti, M. Chiozzotto, M. Ponzoni, A. Ferreri
Journal: Annals of Oncology (2017)
Rotavirus in Spain (2000-2004): a predictive model for a surveillance system
Authors: F J Luquero, J M Eiros, E Sanchez-Padilla, J Castrodeza, F Simón-Soria, R Ortiz de Lejarazu
Journal: Eurosurveillance (2007)

Rotavirus infection is one of the main causes of acute gastroenteritis and has an important impact on hospitalisation. There is no homogeneous surveillance system for rotavirus infections in Europe. The aim of this study is to develop a predictive model in order to estimate the expected rotavirus infections in the population covered by a hospital. A five year study (2000-2004) was developed in a Spanish university hospital. A correlation test between the notifications reported to the Microbiological Information System (SIM) and hospitalisations was carried out, as well as a time series analysis, obtaining the trend and the cyclical components. The predictive model was adjusted using the least squares method. A direct relationship between the microbiological isolations and the hospitalisations was established (=0.925; p&amp;lt;0.001). A significant annual cycle was observed, with the peak of cases occurring in February. The two principal outbreaks that occurred in the study period would have been detected with the predictive model. Expected rotavirus cases and hospitalisations for 2005 and 2006 were obtained. The notifications of rotavirus infections reported to SIM are adequate in order to establish a hospital surveillance system, but a predictive model which provides expected cases is also necessary. Therefore, this tool will be useful to evaluate preventive measures such as rotavirus vaccines, which will soon be available in Europe.
Is Androgen Receptor a predicitive biomarker of response to antiestrogen therapy in advanced breast cancer?
Authors: S. Ravaioli, A. Rocca, G. Bronte, M. Puccetti, M.M. Tumedei, E. Scarpi, R. Maltoni, S. Sarti, L. Cecconetto, D. Andreis, E. Pietri, D. Calistri, D. Amadori, S. Bravaccini
Journal: Annals of Oncology (2017)
Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells
Authors: Garrett C. Heffner, Melissa Bonner, Lauryn Christiansen, Francis J. Pierciey, Dakota Campbell, Yegor Smurnyy, Wenliang Zhang, Amanda Hamel, Seema Shaw, Gretchen Lewis, Kendrick A. Goss, Olivia Garijo, Bruce E. Torbett, Holly Horton, Mitchell H. Finer, Philip D. Gregory, Gabor Veres
Journal: Molecular Therapy (2017)

Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34+ hematopoietic stem and progenitor cells (HSPCs). A small-molecule screen identified prostaglandin E2 (PGE2) as a positive mediator of lentiviral transduction of CD34+ cells. Supplementation with PGE2 increased lentiviral vector (LVV) transduction of CD34+ cells approximately 2-fold compared to control transduction methods with no effect on cell viability. Transduction efficiency was consistently increased in primary CD34+ cells from multiple normal human donors and from patients with β-thalassemia or sickle cell disease. Notably, PGE2 increased transduction of repopulating human HSPCs in an immune-deficient (nonobese diabetic/severe combined immunodeficiency/interleukin-2 gamma receptor null [NSG]) xenotransplantation mouse model without evidence of in vivo toxicity, lineage bias, or a de novo bias of lentiviral integration sites. These data suggest that PGE2 improves lentiviral transduction and increases vector copy number, therefore resulting in increased transgene expression. As a result, PGE2 may be useful in clinical gene therapy applications using lentivirally modified HSPCs.
Burden of Mortality Attributable to Diagnosed Diabetes: A Nationwide Analysis Based on Claims Data From 65 Million People in Germany
Authors: Esther Jacobs, Annika Hoyer, Ralph Brinks, Oliver Kuss, Wolfgang Rathmann
Journal: Diabetes Care (2017)

OBJECTIVE In Germany, as in many other countries, nationwide data on mortality attributable to diagnosed diabetes are not available. This study estimated the absolute number of excess deaths associated with diabetes (all types) and type 2 diabetes in Germany. RESEARCH DESIGN AND METHODS A prevalence approach that included nationwide routine data from 64.9 million people insured in the German statutory health insurance system in 2010 was used for the calculation. Because nationwide data on diabetes mortality are lacking in Germany, the mortality rate ratio from the Danish National Diabetes Register was used. The absolute number of excess deaths associated with diabetes was calculated as the number of deaths due to diabetes minus the number of deaths due to diabetes with a mortality that was as high as in the population without diabetes. Furthermore, the mortality population-attributable fraction was calculated. RESULTS A total of 174,627 excess deaths were due to diabetes in 2010, including 137,950 due to type 2 diabetes. Overall, 21% of all deaths in Germany were attributable to diabetes and 16% were attributable to type 2 diabetes. Most of the excess deaths (34% each) occurred in the 70- to 89-year-old age-group. CONCLUSIONS In this first nationwide calculation of excess deaths related to diabetes in Germany, the results suggest that the official German estimates that rely on information from death certificates are grossly underestimated. Countries without national cohorts or diabetes registries could easily use this method to estimate the number of excess deaths due to diabetes.
N047B: NCCTG phase II trial of vorinostat (suberoylanilide hydroxamic acid) in recurrent glioblastoma multiforme (GBM)
Authors: E. Galanis, K. A. Jaeckle, M. J. Maurer, J. M. Reid, M. M. Ames, C. Giannini, J. S. Hardwick, D. F. Moore, J. A. Zwiebel, J. C. Buckner
Journal: Journal of Clinical Oncology (2007)

2004 Background: Vorinostat is a histone deacetylase inhibitor that represents a rational therapeutic target in GBM. Methods: Recurrent GBM patients (pts) having received = 1 prior chemo regimen for progressive disease were eligible. Vorinostat dose was 200 mg bid x 14 days q 3 weeks. We applied a phase II design which had 90% power to declare the regimen active if the study PFS6 rate was 25%, a 15% rate increase over PFS6 in historical controls (10%). Results: 68 patients were treated. Grade 3+ non-hematologic toxicity consisting mainly of fatigue, diarrhea and dehydration occurred in 23% of pts; Grade 3+ hematologic toxicity consisting mainly of thrombocytopenia occurred in 25% of pts. Intra-patient dose escalation to 300 mg bid resulted in higher incidence of grade 3+ thrombocytopenia (45%) and was aborted. Pts receiving enzyme-inducing anticonvulsants (EIAC) had significantly less grade 3 + non-hematologic toxicity (p=0.01) and grade 3/4 thrombocytopenia (p=0.04). Pharmacokinetic analysis showed lower vorninostat C-max and AUC (0–24h) values and higher vorinostat-glucuronide C-max and AUC (0–24h) values in EIAC pts, although this did not reach statistical significance. The trial met the prospectively defined primary efficacy endpoint at the planned interim analysis with 5 of the first 22 patients (23%) being progression-free at 6 mo. RNA array analysis, performed in paired baseline and post-vorinostat treatment samples in a separate subgroup of 5 surgical recurrent GBM pts, who received vorinostat for 6 doses prior to surgery, showed upregulation of E-cadherin (p=0.02), thus indicating a biologic effect of the HDAC inhibitor on the glioblastoma tumors. Histone acetylation, Akt, phospho-Akt, P21 Waf1/Cip1 and P27 Kip1 expression analysis in all patients and correlation with outcome is ongoing. Conclusions: Vorinostat is well tolerated in recurrent GBM patients. EIAC patients have less toxicity, likely due to increased vorinostat metabolism via glucuronidation. Interim efficacy analysis is indicative of antitumor activity. Final efficacy analysis, RNA array data and correlative tissue analysis will be reported. No significant financial relationships to disclose.
Sorvegliare è agire
Authors: J C Desenclos
Journal: Eurosurveillance (1999)

La sorveglianza deve condurre a degli interventi: questa e la sua filosofia e questa e la sua giustificazione per la sanita pubblica. Questa affermazione ha la sua perfetta esemplificazione nella sorveglianza della Legionellosi. La malattia e trasmessa da vapori gassosi contaminati provenienti da serbatoi infettivi acquosi. Gli ambienti urbani attuali facilitano la moltiplicazione microbica in molti luoghi in cui ristagna acqua calda. La ricerca delle sorgenti di contaminazione responsabili degli episodi epidemici ha permesso di identificarne molte. Sono state adottate misure di controllo per gli impianti per la produzione di acqua calda e per i sistemi di condizionamento d'aria. Comunque, quest'infezione continua a provocare gravi epidemie nella comunita, come dimostra questo numero di Eurosurveillance (1,2,3), creando i presupposti per ulteriori miglioramenti.
Efficacy of two times four versus continuous eight cycles of paclitaxel/bevacizumab as first-line chemotherapy in metastatic breast cancer: The Stop&amp;Go study of the Dutch Breast Cancer Research Group (BOOG)
Authors: A. Claessens, M. Bos, S. de Groot, E. van Leeuwen-Stok, M. Lopez-Yurda, A. Honkoop, H. de Graaf, E. van Druten, L. van Warmerdam, M. van der Sangen, V. Tjan-Heijnen, F. Erdkamp
Journal: Annals of Oncology (2017)
Une épidémie d’hépatite A chez les HSH associée aux relations sexuelles occasionnelles et aux saunas gays à Copenhague, Danemark
Authors: A Mazick, M Howitz, S Rex, I P Jensen, N Weis, T L Katzenstein, J Haff, K Mølbak
Journal: Eurosurveillance (2005)

En 2004, a Copenhague, au Danemark, lors d’une epidemie d’hepatite A qui a touche essentiellement les hommes ayant des relations sexuelles avec d’autres hommes (HSH), une etude cas-controle a ete conduite pour identifier les facteurs de risque d’infection. Un cas a ete defini comme un HSH de plus de 17 ans, resident a Copenhague, presentant une infection par le virus de l’hepatite A avec des IgM positifs diagnostiques entre juin et aout 2004, et n’ayant pas eu de contact avec un cas d’hepatite A parmi ses proches avant l’apparition de la maladie. Les controles ont ete selectionnes au Festival de la Gay Pride a Copenhague. L’etude a porte sur 18 cas et 64 controles. Seize cas et 36 controles avaient des partenaires sexuels occasionnels (ORMH 5,6, 95% CI 1,2-26,9). Onze cas et 14 controles avaient eu des relations sexuelles dans des saunas gays (ORMH 4,2, 95% CI 1,5-11,5). Il semble que les relations dans des domiciles prives aient ete protectrices (ORMH 0,2, 95% CI 0,1-0,7). Les relations occasionnelles incluant des relations dans des saunas gays etaient un important facteur de risque pour la dissemination du VHA chez les HSH a Copenhague. Les resultats concordent avec ceux observes lors d’autres epidemies en Europe. L’immunite generale vis-a-vis de l’hepatite A etant en baisse et le potentiel epidemique en hausse, nous recommandons une education sur ces problemes de sante, ainsi que la vaccination contre l’hepatite A pour tous les homosexuels masculins ne vivant pas en couple stable, en particulier s’ils frequentent des saunas gays ou d’autres lieux ou les changements de partenaires sont frequents. Endiguer la dissemination de l’hepatite A chez les homosexuels masculins en Europe pourrait passer par un consensus a l’echelle europeenne quant aux mesures de prevention et de controle a mettre en place.
Real world use of palliative systemic therapy (tx) in patients (pts) with metastatic early onset colorectal cancer (mEOCRC) within a UK specialist cancer centre
Authors: A. Georgiou, S. Khakoo, A. Minchom, K. Kouvelakis, R. Kalaitzaki, N. Nobar, V. Calamai, M. Ifijen, M. Lethby, F. Arouri, I. Chau, D. Watkins, S. Rao, D. Cunningham, N. Starling
Journal: Annals of Oncology (2017)
Prevalence of KRAS/NRAS/BRAF mutations detected by massive parallel sequencing and differential outcomes in MCRC patients (pts) treated with first line FIr-B/FOx adding bevacizumab (BEV) to triplet chemotherapy
Authors: G. Bruera, F. Pepe, U. Malapelle, P. Pisapia, A. Dal Mas, G. Calvisi, G. Troncone, E. Ricevuto
Journal: Annals of Oncology (2017)
Prognostic Value of Cardiac Magnetic Resonance Tissue Characterization in Risk Stratifying Patients With Suspected Myocarditis
Authors: Christoph Gräni, Christian Eichhorn, Loïc Bière, Venkatesh L. Murthy, Vikram Agarwal, Kyoichi Kaneko, Sarah Cuddy, Ayaz Aghayev, Michael Steigner, Ron Blankstein, Michael Jerosch-Herold, Raymond Y. Kwong
Journal: Journal of the American College of Cardiology (2017)
RANGE: A randomized, double-blind, placebo-controlled phase 3 study of docetaxel (DOC) with or without ramucirumab (RAM) in platinum-refractory advanced or metastatic urothelial carcinoma
Authors: D.P. Petrylak, K.N. Chi, A. Drakaki, C.N. Sternberg, R. de Wit, H. Nishiyama, E.Y. Yu, D. Castellano, S. Hussain, I.J. Percent, A. Fléchon, A. Bamias, M.S. van der Heijden, N. Matsubara, B. Alekseev, R.A. Walgren, O. Hamid, A.H. Zimmermann, K.M. Bell-Mcguinn, T. Powles
Journal: Annals of Oncology (2017)
Folk-economic beliefs: An evolutionary cognitive model
Authors: Pascal Boyer, Michael Bang Petersen
Journal: Behavioral and Brain Sciences (2017)

Abstract The domain of “folk-economics” consists in explicit beliefs about the economy held by laypeople, untrained in economics, about such topics as, for example, the causes of the wealth of nations, the benefits or drawbacks of markets and international trade, the effects of regulation, the origins of inequality, the connection between work and wages, the economic consequences of immigration, or the possible causes of unemployment. These beliefs are crucial in forming people's political beliefs and in shaping their reception of different policies. Yet, they often conflict with elementary principles of economic theory and are often described as the consequences of ignorance, irrationality, or specific biases. As we will argue, these past perspectives fail to predict the particular contents of popular folk-economic beliefs and, as a result, there is no systematic study of the cognitive factors involved in their emergence and cultural success. Here we propose that the cultural success of particular beliefs about the economy is predictable if we consider the influence of specialized, largely automatic inference systems that evolved as adaptations to ancestral human small-scale sociality. These systems, for which there is independent evidence, include free-rider detection, fairness-based partner choice, ownership intuitions, coalitional psychology, and more. Information about modern mass-market conditions activates these specific inference systems, resulting in particular intuitions, for example, that impersonal transactions are dangerous or that international trade is a zero-sum game. These intuitions in turn make specific policy proposals more likely than others to become intuitively compelling, and, as a consequence, exert a crucial influence on political choices.