Review: Procalcitonin-guided starting and stopping of antibiotics in acute respiratory infections reduces mortality
Authors: Christopher R. Carpenter
Journal: Annals of Internal Medicine (2018)

ACP Journal Club20 February 2018Review: Procalcitonin-guided starting and stopping of antibiotics in acute respiratory infections reduces mortalityChristopher R. Carpenter, MD, MScChristopher R. Carpenter, MD, MScWashington University in St. Louis School of Medicine, St. Louis, Missouri, USA (C.R.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2018-168-4-019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSchuetz P, Wirz Y, Sager R, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev. 2017;10:CD007498. https://pubmed.ncbi.nlm.nih.gov/29025194Clinical Impact RatingsGIM/FP/GP: Emergency Med: Hospitalists: Critical Care: Pulmonology: References1 Zaas AK, Garner BH, Tsalik EL, et al. The current epidemiology and clinical decisions surrounding acute respiratory infections. Trends Mol Med. 2014;20:579-88. [PMID: 25201713] Google Scholar2 Schuetz P, Müller B, Christ-Crain M, et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database of Syst Rev. 2012;(9):CD007498. [PMID: 22972110] Google Scholar3 Wirz Y, Branche A, Wolff M, et al. Management of respiratory infections with use of procalcitonin: moving toward more personalized antibiotic treatment decisions. ACS Infect Dis. 2017;3:875-9. [PMID: 29120606] Google Scholar4 Huang DT, Angus DC, Chang CH, et al; ProACT Investigators. Design and rationale of the Procalcitonin Antibiotic Consensus Trial (ProACT), a multicenter randomized trial of procalcitonin antibiotic guidance in lower respiratory tract infection. BMC Emerg Med. 2017;17:25. [PMID: 28851296] Google Scholar5 Fleming-Dutra KE, Hersh AL, Shapiro DJ, et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010-2011. JAMA. 2016;315:1864-73. [PMID: 27139059] Google Scholar6 El Dib R, Tikkinen KAO, Akl EA, et al. Systematic survey of randomized trials evaluating the impact of alternative diagnostic strategies on patient-important outcomes. J Clin Epidemiol. 2017;84:61-9. [PMID: 28063913] Google Scholar Author, Article, and Disclosure InformationAffiliations: Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA (C.R.C.)This article was published at Annals.org on 6 February 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProcalcitonin-guided antibiotic therapy for pediatrics with infective disease: A updated meta-analyses and trial sequential analysis 20 February 2018Volume 168, Issue 4Page: JC19KeywordsAntibioticsIntensive care unitsMortalityOdds ratioPatientsPharyngitisPulmonary medicineRespiratory system proceduresSafetyUpper respiratory tract infections ePublished: 20 February 2018 Issue Published: 20 February 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...