tbuckley/cabot-search huggingface dataset:
Effective Targeting of Quiescent CML Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate.
Authors: Bin Zhang, Adam Campbell Strauss, Su Chu, Yin Wei Ho, David S. Snyder, Claudia Huettner, Lenny Shultz, Tessa L Holyoake, Ravi Bhatia
Journal: Blood (2009)
Evidence for the Involvement of CXCR4 Signaling in In Vivo Self-Renewal of Transplanted Hematopoietic Stem Cells
Authors: Chen-YI LAI, Makoto Otsu, Motohito Okabe, Sachie Suzuki, Satoshi Yamazaki, Masafumi Onodera, Hideo Ema, Shigeru Kakuta, Yoichiro Iwakura, Hiromitsu Nakauchi
Journal: Blood (2011)
Breast cancer evaluation and targeted investigational therapy (BEAT-IT): A pilot prospective tissue testing to guide clinical trial selection.
Authors: Lajos Pusztai, Danielle Mattair, Naoto T. Ueno, Vicente Valero, Stacy L. Moulder, James L. Murray, Ricardo H. Alvarez, Mariana Chavez-Mac Gregor, Lumarie Santiago, Rony Avritscher, Aysegul A. Sahin, Gabriel N. Hortobagyi, William Fraser Symmans, Funda Meric-Bernstam, Elizabeth M Burton, Ana M. Gonzalez-Angulo
Journal: Journal of Clinical Oncology (2013)

532 Background: An increasing number of molecularly targeted drugs are now available in Phase I and II clinical trials. Many of these drugs target specific molecular abnormalities such as mutated, amplified or rearranged genes. Our hypothesis is that cancers that carry a molecular abnormality that corresponds to the mechanism of action of a given investigational drug are more sensitive to that particular drug than other cancers. The objective of this study is to perform molecular analysis of metastatic breast cancer biopsies (bx) using methods already established within CLIA approved laboratories, and to use the results to triage pts to various therapeutic clinical trials or standard of care therapy. Methods: Four core needle biopsies (CNB) and 4 fine needle aspirations (FNA), or 8 FNA are obtained from the most safely accessible metastatic site in a single bx session. Pathological confirmation of successful aspiration is performed. Two core bx (or 4 FNA passes) are formaldehyde fixed and paraffin embedded for Immunohistochemistry (IHC), FISH and mutation analysis (CMS11 or CMS46) and 4 FNA are placed in RNA-later and snap-frozen for transcriptional profiles and storage. Samples are transferred to the Molecular Diagnostic, IHC, and Cytogenetics Laboratories. All reports are included in the electronic medical record. Results: FromFeb 2012 to Jan 2013, 142 pts referred, 128 pts registered, 101 bx completed and 78 (77%) bx with available results. Bx sites included: liver (37), lymph node (26), soft tissue (16), bone (13), lung (5), other (4). Successful results were obtained for IHC: PTEN (73%), AR (78%), MET (73%), FISH: EML4-ALK (78%) and MET (74%), and mutation analysis (76%). To date, there have been no reported hospitalizations, ER visits, bleeding, pain, infection or organ dysfunction at the bx sites. 16 pts have been treated on trials with investigational agents hypothesized to result in response based upon the molecular profile of the tumor. Conclusions: Prospective tissue collection to determine the molecular targets and to evaluate pts for clinical trial selection is feasible and safe.
Splenectomy in childhood idiopathic thrombocytopenic purpura: Results of the splenectomy registry.
Authors: T Kuhne, [No Value] Blanchette, O Smith, G Buchanan, U Ramenghi, G Wrobel, S Zimmerman, Ryj Tamminga, P Imbach, Intercontinental Childhood Itp Stu
Journal: Blood (2003)
High Levels of B-Cell Activating Factor During the Peri-Transplant Period Are Associated with the Reduced Incidence of Acute Graft-Versus-Host Disease Following the Myeloablative Allogeneic Stem Cell Transplantation.
Authors: Byung Sik Cho, Chang Ki Min, Hee Je Kim, Seok Lee, Yoo Jin Kim, Dae-Chul Jeong, Bin Cho, Hack Ki Kim, Ki-Seong Eom, Seok Goo Cho, Dong Wook Kim, Jong Wook Lee, Woo Sung Min, Jong Won Park, Chun Choo Kim, Nak Gyun Chung
Journal: Blood (2009)
Tumor Cell-Associated Tissue Factor Supports Metastatic Potential through Both NK Cell-Dependent and -Independent Mechanisms.
Authors: Joseph Palumbo, Kelley A. Barney, Matthew J. Flick, Kathryn E. Talmage, Keith W. Kombrinck, Zhiwei Hu, Christine M. La Jeunesse, Jay L. Degen
Journal: Blood (2006)
Single Cell RNA Sequencing Reveals Increased Adhesion Signals in Treatment-Resistant Tumor Stem Cells in a Preclinical Mouse Model of Genetically Engineered Patient-Derived Acute Lymphoblastic Leukemia
Authors: Ebinger Sarah, Özdemir Erbey, Sebastian Tiedt, Christoph Ziegenhain, Catarina Castro Alves, Wolfgang Enard, Irmela Jeremias
Journal: Blood (2015)
MTR-21DECOY RECEPTOR DcR1 IS INDUCED IN A p50/Bcl3-DEPENDENT MANNER AND ATTENUATES THE EFFICACY OF TEMOZOLOMIDE
Authors: Nassir Mansour, Giovanna Bernal, Longtao Wu, David Voce, Clayton Crawley, Bakhtiar Yamini
Journal: Neuro-Oncology (2015)

INTRODUCTION: Temozolomide (TMZ) is widely used in the management of malignant glioma. Given that almost all patients receive TMZ, resistance to this agent plays a major role in overall patient prognosis. The transcription factor, NF-κB plays an important role in the cytotoxic response to TMZ. To identify novel factors that modulate cytotoxicity, we used an unbiased strategy to examine the NF-κB-dependent expression profile induced by TMZ. Decoy receptor 1 (DcR1), a TNF superfamily receptor that blocks apoptosis, was identified as a significantly induced NF-κB-dependent gene. In the current work, we studied DcR1 in response to TMZ. METHODS: DcR1 expression was examined following TMZ treatment by qPCR and western blot in several glioma cells and DcR1 expression studied in public glioma databases. Regulation of DcR1 expression was examined using promoter/reporter, binding and chromatin immunoprecipitation studies. Apoptosis and clonal survival was examined and in vivo studies performed following nanoparticle-mediated delivery of siRNA targeting DcR1. RESULTS: DcR1 is induced by TMZ in an NF-κB and p53-dependent manner with a time course consistent with activation of NF-κB. A conserved NF-κB binding sequence was identified in the proximal promoter and is required for DcR1 induction by TMZ. Loss-of-function and gain-of-function studies reveal that the atypical IκB protein, Bcl3, is also required for induction of DcR1 by TMZ. Mechanistically, DcR1 attenuates TMZ efficacy by blunting activation of the Fas receptor pathway in p53 wildtype glioma cells. Intracranial xenograft studies demonstrate that DcR1 depletion enhances the efficacy of TMZ and database analyses indicate that patients with higher DcR1 expression have poorer survival. CONCLUSIONS: DcR1 is up-regulated following TMZ treatment and mediates resistance to therapy. These findings provide a rationale for DcR1 targeting as a strategy to sensitize gliomas to TMZ.
A Complex Karyotype but Not Monosomy 7 Is an Independent Prognostic Factor in Advanced Childhood MDS.
Authors: Gudrun Gohring, Kyra Michalova, Berna Beverloo, David Betts, Jochen Harbott, Oskar Haas, Gitte Kerndrup, Laura Sainati, Eva Bergstraesser, Henrik Hasle, Jan Starý, Monika Trebo, Marry van den Heuvel-Eibrink, Marco Zecca, Alexandra Fischer, Peter Noellke, Franco Locatelli, Brigitte Schlegelberger, Charlotte M. Niemeyer
Journal: Blood (2007)
PRELIMINARY EVIDENCE ON THE EFFICACY OF CRANIAL OSTEOPATHY IN PROFESSIONAL FOOTBALL
Authors: Frederic Van Burm, Arnold Goedhart
Journal: British Journal of Sports Medicine (2017)

Background The training and match injury-incidence in professional men's football remains high and current preventive strategies only seem partially effective, allowing players to present with intrinsic weaknesses each consecutive season. Professional football is a balance-reliant, open skill performed in an environment rich in visual, vestibular and proprioceptive input. Pre-season balance ability - a significant independent intrinsic predictor of injuries and a long-term persisting between-individual difference in injury susceptibility – depends on this input. Measurements of postural control while in a unilateral stance have been shown to predict football injury-susceptibility. Therefore, effective prevention of injury may start with the measurement of postural control followed by interventions targeted at internal risk factor(s). Stomatognathic conditions/malocclusion may have a strong negative impact on the athletes proprioceptive abilities. Therefore, the primary question in this study was: do cranial osteopathic interventions that reduce malocclusion to the better improve balance control in male elite football players? Aim This study aimed at investigating dental/occlusal factors and unilateral balance as non-contact injury risk factors in professional football players and the contribution of osteopathic techniques to decrease these risks. Method Sixty three injury-free male professional football players with malocclusion were recruited amongst three Belgian Premier League teams and were tested individually. Balance was measured using COF area recordings during a validated unipodal force plate balance test. Four balance test conditions (dominant/non-dominant leg×eyes open/closed) were used to evaluate the short-term effects of three standardized cranial osteopathic techniques. Results All the post-treatment measures show smaller mean COF values (balance improvement) when compared to pre-treatment base-line recordings, with the strongest improvement for the conditions with eyes closed (paired t-test, p&lt;0.0005). Indicators of stomatognathic conditions showed significant correlations with base-line COF and balance improvement. Conclusions This study indicates that cranial osteopathic interventions with professional football players result in substantial improvement of balance in challenging test conditions (i.e. standing on one leg with eyes closed), and especially if one or more specific stomatognathic conditions are present. Improvement of balance as a non-specific indicator of injury susceptibility and of soccer performance is a dynamic process that involves many features, that could be included in future prospective studies. The results are suggestive for implementation of this approach in football, but at the same time point at the need for follow-up studies with a larger sample size and long-term evaluation.
Dose Finding in Human Trials of TLR9 Agonists: Induction of Interferon-α Inducible Genes in Blood Mononuclear Cells as a Measure of Biologic Activity of 1018 ISS.
Authors: James N. Lowder, Jonathan W. Freidberg, Jennifer Kelly, Arnold S. Freedman, Robert Coffman, Holger Kanzler, Paul Sims, Jimmy Hwang, Nicholas Haining
Journal: Blood (2007)
Seeing and thinking: Foundational issues and empirical horizons
Authors: Chaz Firestone, Brian J. Scholl
Journal: Behavioral and Brain Sciences (2016)

The spectacularly varied responses to our target article raised big-picture questions about the nature of seeing and thinking, nitty-gritty experimental design details, and everything in between. We grapple with these issues, including the ready falsifiability of our view, neuroscientific theories that allow everything but demand nothing, cases where seeing and thinking conflict, mental imagery, the free press, an El Greco fallacy fallacy, hallucinogenic drugs, blue bananas, subatomic particles, Boeing 787s, and the racial identities of geometric shapes.
Induction of Fetal Hemoglobin Synthesis By Crispr/Cas9-Mediated Disruption of the β-Globin Locus Architecture
Authors: Chiara Antoniani, Vasco Meneghini, Annalisa Lattanzi, Giulia Pavani, Tristan Felix, Fatima Amor, Oriana Romano, Elisa Magrin, Leslie Weber, Thomas Cradick, Ante S Lundberg, Matthew Porteus, Mario Amendola, Marina Cavazzana, Fulvio Mavilio, Annarita Miccio
Journal: Blood (2016)
EPIG-12EPIGENETIC MODULATION OF A miR-296-5p:HMGA1 AXIS REGULATES THE GLIOBLASTOMA STEM CELL PHENOTYPE
Authors: Hernando Lopez-Bertoni, Bachchu Lal, Nicole Michelson, John Laterra
Journal: Neuro-Oncology (2015)

The long term goal of our research is to understand the cellular and molecular mechanisms that regulate brain tumor malignancy. Cell subsets isolated from glioblastoma (GBM) have the capacity to grow as spheres (i.e. neurospheres) and efficiently propagate tumors in xenograft models, reflecting a stem-like, self-renewing and tumor-propagating phenotype. Furthermore, GBM stem-like cells have been shown to maintain tumor growth, contribute to resistance, and there is strong evidence suggesting their role in tumor recurrence. Characterizing the basic mechanisms driving this phenotype will allow us to identify new therapeutic targets and treatment strategies. Cell fate determination and phenotype reprogramming are complex and dynamic processes that involve epigenetic mechanisms and differentially regulated coding and non-coding RNAs. We recently showed that the coordinated actions of Oct4 and Sox2 induce a tumor-propagating stem-like state in GBM cells via a mechanism involving direct DNMT promoter transactivation, DNA methylation, and methylation-dependent repression of multiple miRNAs. However, how specific epigenetic changes contribute to the acquisition and/or maintenance of the cancer stem-like phenotype remains unclear. This study focuses on understanding the cross-talk between specific DNA methylation events, miRNA expression and regulation, and the GBM-propagating stem cell phenotype. We show that miR-296-5p expression is repressed in a DNA methylation-dependent manner under conditions that promote GBM cell stemness and that forced expression of miR-296-5p inhibits self-renewal capacity of GBM neurosphere cells in vitro and the growth of neurosphere-derived glioma xenografts in vivo. Additionally, we identify the chromatin remodeling protein HMGA1 as downstream effector of miR-296-5p action in the context of GBM stem-like cells. These results show that miR-296-5p regulate chromatin architecture by targeting HMGA1 and that the miR-296-5p:HMGA1 axis as a novel regulator of the GBM stem cell phenotype and a candidate pathway for targeted therapies directed at depleting tumors of their tumor-propagating stem cell subsets.
ATPS-88TEMOZOLOMIDE AND EVEROLIMUS IN THE TREATMENT OF PAPILLARY TUMOR OF THE PINEAL REGION
Authors: Tyler R. West, Scott G. Turner, Syed Aj Kazmi, Lynn Belles, Angela Whitmire, Michel Lacroix, Steven A. Toms
Journal: Neuro-Oncology (2015)

Papillary tumor of the pineal region (PTPR) is a rare neuroepithelial tumor thought to arise from the ependymal cells of the subcommissural organ which was first described in 2003 and subsequently classified as a Grade II-III tumor in the WHO registry in 2007. They tend to be well-circumscribed, occasionally cystic tumors that, histologically, consist of sheets of epithelioid cells and perivascular pseudorosettes with papillary structures consisting of cuboidal cells. These tumors have a high rate of local recurrence but infrequent CSF dissemination. Because fewer than 100 cases have been reported, a consensus on treatment has not been reached, though maximal surgical resection correlates with a better prognosis and radiotherapy may confer a benefit, as well. The role of chemotherapy remains unclear and regimens including procarbazine, lomustine, and vincristine as well at temozolomide have been reported. Recently, chromosome 10 deletions and mutations in the PTEN (phosphatase and tensin homolog) gene located on chromosome 10 are common in PTPR. Because PTEN is involved in the PI3K/Akt/mTOR signaling pathway, mTOR inhibitors, such as everolimus may be effective against this tumor type. We present a patient with PTPR who underwent complete resection followed by local radiotherapy. He later developed leptomeningeal disease and underwent whole brain radiation therapy. He was also treated with metronomic temozolomide and subsequently by everolimus after he developed a temozolomide-resistant durally-based metastatic lesion.
Effect of a histone deacetylase inhibitor on antitumor effect of gemcitabine to focus the gene network of ingenuity pathways analysis.
Authors: S. Iwahashi, M. Shimada, T. Utsunomiya, S. Imura, Y. Morine, T. Ikemoto, H. Mori, J. Hanaoka, Y. Saito
Journal: Journal of Clinical Oncology (2011)

230 Background: Histone deacetylase (HDAC) is strongly associated with epigenetic regulation and carcinogenesis, and its inhibitors induce the differentiation or apoptosis of cancer cells. Valproic acid (VPA) is one of the clinically available HDAC inhibitors. We previously showed that VPA augmented antitumor effect of GEM in choalngiocarcinoma cell line (2010 GI Symposium); this time, we performed microarray analysis and Ingenuity Pathways Analysis (IPA) to identify the systematic mechanism of the augmentative effect of VPA. Methods: Human cholangiocarcinoma cell line (HuCCT1) was used. The anticancer effects of VPA or gemcitabine (GEM), and the effects of VPA combined with GEM were studied by MTT assay. We divided the following four groups: control group, VPA group, GEM group, VPA plus GEM combination group. The gene expressions of p21, HDAC, VEGF, and HIF-1 were evaluated by RT-PCR. And, the microarray analysis was performed, the genes were picked up using Gene Spring GX10, and then IPA was performed. Results: In GEM alone group, no effect of GEM was observed in dose of 5 mm, and 16% of proliferation-inhibitory effects were observed in dose of 10 nm. In VPA alone group, no effect of VPA was observed in dose of 0.5 mm, and 12%, 35%, and 67% of proliferation-inhibitory effects were observed in dose of 1.0, 5.0, and 10mm, respectively. GEM (5 nm) and VPA (0.5 mm) reduced by 23%, which significantly augmented the anticancer effect of GEM alone or VPA alone (p&lt;0.01). Furthermore, GEM combined with VPA upregulated the p21 expression compared with single agent (p&lt;0.05). And, in regard to microarray analysis, we analyzed in 28,869 genes. The 24 genes were picked up with the comparison between VPA group and VPA plus GEM combination group using Gene Spring GX10, and the gene network of the cellular development containing the gene relevant to the differentiation of cancer cell, HLA-DR, was formed with IPA. Conclusions: VPA augmented the effects of anticancer agents in a cholangiocarcinoma cell line. Such effects may be owing to the gene network of the cellular development. HDAC inhibitor may have the effect of the differentiation of cancer cell. No significant financial relationships to disclose.
Results of the ECOG E1900 Trial in Younger Adults with AML Using an Event Free Survival Endpoint Are Concordant with Results Based on Overall Survival: Potential for a Surrogate Endpoint to Facilitate Rapid Approval of Therapies in AML
Authors: Marlise R. Luskin, Ju-Whei Lee, Hugo F. Fernandez, Hillard M. Lazarus, Jacob M. Rowe, Martin S. Tallman, Elisabeth M. Paietta, Mark Litzow, Omar Abdel-Wahab, Jay P. Patel, Ross L. Levine, Zhuoxin Sun, Selina M. Luger
Journal: Blood (2014)
Mammography and the uninsured: Community-based organizations to the rescue
Authors: A. D. Brooks, S. Krishnamoorthy, A. Prestrud, A. M. Zucker
Journal: Journal of Clinical Oncology (2005)

1031 Background∼Appropriate means to ensure timely access to breast screening services evades health professionals. Community-based organizations must be cognizant of sociodemographic descriptors of their constituents. Underserved women, including those with limited education and unstable employment, require assistance to seek out and utilize health programs. Methods∼A cross-sectional analysis of participants in a regional breast health program assessed the role of sociodemographic variables in predicting utilization rates of community-based programs for breast health. Analysis using chi-square and ANOVA identified sociodemographic factors influencing referral patterns, e.g. community organization versus self-referral. Results∼A database tracking breast health program enrollees (n=261) includes a subset of Southeast Asian immigrant women (27%), referred by community organizations. The median age of the total sample was 55.4 years. The majority of participants reported being married (30%), renting or owning a home (49%), participating in self-care (77%), high school educated (37%), and employed full-time (30%). Chi-square analysis further indicated a significant relationship (p<0.05) between community referral and marital status; if immigrant women are married, then they are more likely to enlist the services of a community agency. A significant association exists between community referral patterns, education (p<0.05) and employment (p<0.05); immigrant women with limited education or financial security are also more likely to solicit community assistance. Variables of living arrangements (p=NS) and primary caregiver status (p=NS), were insignificant predictive factors for referral type. Conclusion∼Preliminary investigation yields great insight concerning the need for community-based organizations in the recruitment of immigrant women for breast health services. Increased awareness about sociodemographic predictors, including marital status, education, and employment allows for more targeted enrollment and assistance. Together clinicians and community-based organizations can empower underserved women to overcome barriers to effective and efficient breast health services. No significant financial relationships to disclose.
Bcr-Abl Tyrosine Kinase Domain Mutations Both Pre-Exist and Develop during Imatinib Treatment and Are Responsible for Resistance in Patients with Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL).
Authors: Heike Pfeifer, Barbara Wassmann, Anna Pavlova, Lydia Wunderle, Patrick Brueck, Andreas Hochhaus, Dieter Hoelzer, Oliver Ottmann
Journal: Blood (2006)
Dexamethasone(DEX)(6mg/sm/d) and Prednisolone(PRED)(60mg/sm/d) in Induction Therapy of Childhood ALL Are Equally Effective: Results of the 2nd Interim Analysis of EORTC Trial 58951
Authors: Yves Bertrand, Stefan Suciu, Yves Benoit, Alain Robert, Brigitte Nelken, Anne Uyttebroeck, Patrick Lutz, Alice Ferster, Andre Baruchel, Lucilia Norton, Geneviève Margueritte, Pierre-Simon Rohrlich, Martine Munzer, Dominique Plantaz, Frédéric Millot, Patrick Boutard, Nicolas Sirvent, Claire Hoyoux, Liliana Baila, Jacques Otten
Journal: Blood (2008)
Attention and multisensory modulation argue against total encapsulation
Authors: Benjamin de Haas, Dietrich Samuel Schwarzkopf, Geraint Rees
Journal: Behavioral and Brain Sciences (2016)

Abstract Firestone &amp; Scholl (F&amp;S) postulate that vision proceeds without any direct interference from cognition. We argue that this view is extreme and not in line with the available evidence. Specifically, we discuss two well-established counterexamples: Attention directly affects core aspects of visual processing, and multisensory modulations of vision originate on multiple levels, some of which are unlikely to fall “within perception.”
Long-Term Follow-Up of Multiple Myeloma (MM) Patients (pts) with Osteonecrosis of the Jaw (ONJ).
Authors: Ashraf Badros, T. Evangelos, O. Goloubeva, T. Meiller, E. Kastritis, E. Verrou, K. Zervas, E. Katodritou, E. Streeten, M.R. Baer, M.A. Dimopoulos
Journal: Blood (2007)
Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer
Authors: William U. Shipley, Wendy Seiferheld, Himanshu R. Lukka, Pierre P. Major, Niall M. Heney, David J. Grignon, Oliver Sartor, Maltibehn P. Patel, Jean-Paul Bahary, Anthony L. Zietman, Thomas M. Pisansky, Kenneth L. Zeitzer, Colleen A.F. Lawton, Felix Y. Feng, Richard D. Lovett, Alexander G. Balogh, Luis Souhami, Seth A. Rosenthal, Kevin J. Kerlin, James J. Dignam, Stephanie L. Pugh, Howard M. Sandler
Journal: New England Journal of Medicine (2017)

Salvage radiation therapy is often necessary in men who have undergone radical prostatectomy and have evidence of prostate-cancer recurrence signaled by a persistently or recurrently elevated prostate-specific antigen (PSA) level. Whether antiandrogen therapy with radiation therapy will further improve cancer control and prolong overall survival is unknown.