tbuckley/cabot-search huggingface dataset:
Contempt as the absence of appraisal, not recognition, respect
Authors: Michelle Mason
Journal: Behavioral and Brain Sciences (2017)

Abstract Gervais &amp; Fessler's defense of a sentiment construct for contempt captures features distinguishing the phenomenon from basic emotions and highlights the fact that it comprises a coordinated syndrome of responses. However, their conceptualization of contempt as the absence of respect equivocates. Consequently, a “dignity” culture that prescribes respect does not thereby limit legitimate contempt in the manner the authors claim.
Branched peptides as targeting agents for tumor imaging and therapy
Authors: Barbara Lelli, Chiara Falciani, Silvia Pileri, Alessandro Pini, Jlenia Brunetti, Alessandra Cappelli, Ester Cotti Piccinelli, Lapo Bencini, Renato Moretti, Luisa Bracci
Journal: Cancer Research (2008)

4072   Membrane receptors for endogenous peptides like Somatostatin, Neurotensin, Bombesin and many others, are over-expressed in different human cancers and might be targeted as tumor-specific antigens. Efficiency of peptide-receptor targeting depends on the presence and concentration of receptors on neoplastic tissues. Receptor-specific diagnostic tools would be extremely useful to predict the efficacy of a treatment aimed at the same receptors, provided that molecules used for receptor tracing have similar binding efficiency than those used for therapy.  Our goal is producing peptide molecules that can be used for both a specific receptor-tracing test and for therapy or in vivo imaging, by delivering radio or chemotherapeutic moieties to the same receptors on tumor cells. Branched peptide molecules can be used for both purposes with no modification of the tumor targeting moiety, but only by addition of different functional units, like chromophores, radio or chemotherapic moieties, to the conserved branched core. Moreover, branched peptides have the additional advantage of a longer half-life caused by a much higher resistance to proteolysis, compared to linear peptides (1, 2).  We previously demonstrated that neurotensin (NT), when synthesized as a tetra-branched dendrimer, retains biological activity and becomes resistant to proteases (1).  Tetrabranched NT conjugated to fluorophores was synthesized and tested for receptor binding on different human tumor cell lines. Once verified that conjugation to functional units did not reduce receptor binding of branched peptides, we tested our molecules on samples from surgical resection of colon and pancreas adenocarcinoma, in comparison with healthy tissues from the same patients. Confocal images show a general good staining of most tumor samples by branched NT and a much lower staining of healthy tissue from the same patients, indicating a good selectivity of the peptide. The same tetrabranched peptide was conjugated to different chemotherapic drugs and tested for cytotoxicity toward tumor cells in vitro and in animal models (3). Results indicate very promising features of branched NT for selective tumor targeting.
TCT-24 Subadventitial Crossing and Crushing to Recanalize In-stent Chronic Total Occlusions: A Multicenter Registry
Authors: Lorenzo Azzalini, Aris Karatasakis, James Spratt, Peter Tajti, Luiz Ybarra, Susanna Benincasa, Barbara Bellini, Luciano Candilio, Francisco Hidalgo, Leo Timmers, Adriaan Kraaijeveld, Pierfrancesco Agostoni, James Roy, David Ramsay, James Weaver, Paul Knaapen, Boris Starcevic, Soledad Ojeda, Manuel Pan, Khaldoon Alaswad, William Lombardi, Stéphane Rinfret, Mauro Carlino, Emmanouil Brilakis, Antonio Colombo, Kambis Mashayekhi
Journal: Journal of the American College of Cardiology (2017)
Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior
Authors: Yan Li, Anqi Yin, Xin Sun, Ming Zhang, Jianfang Zhang, Ping Wang, Rougang Xie, Wen Li, Ze Fan, Yuanyuan Zhu, Han Wang, Hailong Dong, Shengxi Wu, Lize Xiong
Journal: Journal of Clinical Investigation (2017)

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent psychiatric disorder in children. Although an imbalance of excitatory and inhibitory inputs has been proposed as contributing to this disorder, the mechanisms underlying this highly heterogeneous disease remain largely unknown. Here, we show that N-myc downstream-regulated gene 2 (NDRG2) deficiency is involved in the development of ADHD in both mice and humans. Ndrg2-knockout (Ndrg2-/-) mice exhibited ADHD-like symptoms characterized by attention deficits, hyperactivity, impulsivity, and impaired memory. Furthermore, interstitial glutamate levels and excitatory transmission were markedly increased in the brains of Ndrg2-/- mice due to reduced astroglial glutamate clearance. We developed an NDRG2 peptide that rescued astroglial glutamate clearance and reduced excitatory glutamate transmission in NDRG2-deficient astrocytes. Additionally, NDRG2 peptide treatment rescued ADHD-like hyperactivity in the Ndrg2-/- mice, while routine methylphenidate treatment had no effect on hyperactivity in these animals. Finally, children who were heterozygous for rs1998848, a SNP in NDRG2, had a higher risk of ADHD than children who were homozygous for rs1998848. Our results indicate that NDRG2 deficiency leads to ADHD phenotypes and that impaired astroglial glutamate clearance, a mechanism distinct from the well-established dopamine deficit hypothesis for ADHD, underlies the resultant behavioral abnormalities.
Undertriage Remains a Vexing Problem for Even the Most Highly Developed Trauma Systems
Authors: Craig D. Newgard, Tarsicio Uribe-Leitz, Adil H. Haider
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Mutations of the integrin αIIb/β3 intracytoplasmic salt bridge cause macrothrombocytopenia and enlarged platelet α‐granules
Authors: Marie Favier, Jean‐Claude Bordet, Remi Favier, Vasiliki Gkalea, Xavier Pillois, Philippe Rameau, Najet Debili, Marie‐Christine Alessi, Paquita Nurden, Hana Raslova, Alan Nurden
Journal: American Journal of Hematology (2017)

Rare gain-of-function mutations within the ITGA2B or ITGB3 genes have been recognized to cause macrothrombocytopenia (MTP). Here we report three new families with autosomal dominant (AD) MTP, two harboring the same mutation of ITGA2B, αIIbR995W, and a third family with an ITGB3 mutation, β3D723H. In silico analysis shows how the two mutated amino acids directly modify the salt bridge linking the intra-cytoplasmic part of αIIb to β3 of the integrin αIIbβ3. For all affected patients, the bleeding syndrome and MTP was mild to moderate. Platelet aggregation tended to be reduced but not absent. Electron microscopy associated with a morphometric analysis revealed large round platelets; a feature being the presence of abnormal large α-granules with some giant forms showing signs of fusion. Analysis of the maturation and development of megakaryocytes reveal no defect in their early maturation but abnormal proplatelet formation was observed with increased size of the tips. Interestingly, this study revealed that in addition to the classical phenotype of patients with αIIbβ3 intracytoplasmic mutations there is an abnormal maturation of α-granules. It is now necessary to determine if this feature is a characteristic of all mutations disturbing the αIIb R995/β3 D723 salt bridge.
A New Theranostic System Based on Endoglin Aptamer Conjugated Fluorescent Silica Nanoparticles
Authors: Juntao Tan, Nuo Yang, Liping Zhong, Jie Tan, Zixi Hu, Qing Zhao, Wenlin Gong, Zhenghua Zhang, Rong Zheng, Zongqiang Lai, Yanmei Li, Chaofan Zhou, Guoqing Zhang, Duo Zheng, Ying Zhang, Siyu Wu, Xinglu Jiang, Jianhong Zhong, Yong Huang, Sufang Zhou, Yongxiang Zhao
Journal: Theranostics (2017)

Background: Tumor vessels can potentially serve as diagnostic, prognostic and therapeutic targets for solid tumors. Fluorescent dyes are commonly used as biological indicators, while photobleaching seriously hinders their application. In this study, we aim to generate a fluorescent silica nanoparticles (FSiNPs) theranostic system marked by the mouse endgolin (mEND) aptamer, YQ26. Methods: A highly specific YQ26 was selected by using gene-modified cell line-based SELEX technique. FSiNPs were prepared via the reverse microemulsion method. The YQ26-FSiNPs theranostic system was developed by combining YQ26 with the FSiNPs for in vivo tumor imaging, treatment and monitoring. Results: Both in vitro experiments (i.e. cellular and tumor tissue targeting assays) and in vivo animal studies (i.e. in vivo imaging and antitumor efficacy of YQ26-FSiNPs) clearly demonstrated that YQ26-FSiNPs could achieve prominently high targeting efficiency and therapeutic effects via aptamer YQ26-mediated binding to endoglin (END) molecule. Conclusion: This simple, sensitive, and specific YQ26-FSiNPs theranostic system has a great potential for clinical tumor targeting imaging and treatment.
IMPACT OF LEFT VENTRICULAR OUTFLOW TRACT (LVOT) MORPHOLOGY AND LVOT-ANNULAR MISMATCH ON PARAVALVULAR LEAK AND NEW CONDUCTION ABNORMALITIES AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT: CONCEPT OF THE “NON-TUBULAR INDEX” AND LVOT SEAL ZONE
Authors: Gilbert Hin-Lung Tang, Syed Zaid, Samuel Schnittman, Hasan Ahmad, Ryan Kaple, Cenap Undemir, Tanya Dutta, Angelica Poniros, Joanne Bennett, Cheng Feng, Martin Cohen, Steven Lansman
Journal: Journal of the American College of Cardiology (2018)
Why doctors consider leaving UK medicine: qualitative analysis of comments from questionnaire surveys three years after graduation
Authors: Trevor W Lambert, Fay Smith, Michael J Goldacre
Journal: Journal of the Royal Society of Medicine (2017)

Objective To report the reasons why doctors are considering leaving medicine or the UK. Design Questionnaire survey. Setting UK. Participants Questionnaires were sent three years after graduation to all UK medical graduates of 2008 and 2012. Main outcome measures Comments from doctors about their main reasons for considering leaving medicine or the UK (or both). Results The response rate was 46.2% (5291/11,461). Among the 60% of respondents who were not definitely intent on remaining in UK medicine, 50% were considering working in medicine outside the UK and 10% were considering leaving medicine. Among those considering working in medicine outside the UK, the most commonly cited reasons were to gain wider experience, that things would be ‘better’ elsewhere and a negative view of the National Health Service and its culture, state and politics. Other reasons included better training or job opportunities, better pay and conditions, family reasons and higher expectations. Three years after graduation, doctors surveyed in 2015 were significantly more likely than doctors surveyed in 2011 to cite factors related to the National Health Service, to pay and conditions, to their expectations and to effects on work–life balance and patient care. Among those considering leaving medicine, the dominant reason for leaving medicine was a negative view of the National Health Service (mentioned by half of those in this group who commented). Three years after graduation, doctors surveyed in 2015 were more likely than doctors surveyed in 2011 to cite this reason, as well as excessive hours and workload, and financial reasons. Conclusions An increasingly negative view is held by many doctors of many aspects of the experience of being a junior doctor in the National Health Service, and the difficulty of delivering high-quality patient care within what many see as an under-funded system. Policy changes designed to encourage more doctors to remain should be motivated by a desire to address these concerns by introducing real improvements to resources, staffing and working conditions.
17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle
Authors: Maria J. Torres, Kim A. Kew, Terence E. Ryan, Edward Ross Pennington, Chien-Te Lin, Katherine A. Buddo, Amy M. Fix, Cheryl A. Smith, Laura A. Gilliam, Sira Karvinen, Dawn A. Lowe, Espen E. Spangenburg, Tonya N. Zeczycki, Saame Raza Shaikh, P. Darrell Neufer
Journal: Cell Metabolism (2017)
Il sistema di sorveglianza di laboratorio delle infezioni da Chlamydia trachomatis e Neisseria gonorrhoeae in Danimarca
Authors: S Hoffmann
Journal: Eurosurveillance (2001)

Questo articolo presenta i risultati della sorveglianza delle infezioni da C. trachomatis e N. gonorrhoeae in Danimarca. Nel 1999 e nel 2000, ci sono stati rispettivamente 291 e 309 casi maschili di gonorrea confermata in laboratorio, mentre il numero di casi femminili e stato di 43 per entrambi gli anni. E’ rimasta stabile la resistenza alla penicillina, con una prevalenza del 40% nel 1999, mentre la prevalenza della resistenza al fluorochinolone e aumentata da 0% nel 1990 al 27% nel 1999. Il numero di infezioni da C. trachomatis confermati in laboratorio rimane di circa 13 000 casi per anno. I maschi di 20–29 anni e le femmine di 15–24 sono i gruppi a piu alto rischio.
Undécimo taller internacional de trabajo en materia de Campylobacter, Helicobacter y organismos afines (11th International Workshop on Campylobacter, Helicobacter and related Organisms; CHRO), 2001
Authors: J Takkinen, A Ammon
Journal: Eurosurveillance (2003)

Mas de setecientos participantes de cincuenta y cuatro paises asistieron a la undecima reunion en materia de Campylobacter, Helicobacter y organismos afines (11th International Workshop on Campylobacter, Helicobacter and related Organisms; CHRO) celebrada en septiembre de 2001. Esta reunion brindo la oportunidad de poner al dia y conocer mejor las complejidades microbiologicas y epidemiologicas del Campylobacter. Aun no se conoce por completo el mecanismo de la patogenesis de esta bacteria, habiendose experimentado un avance importante en la caracterizacion microbiologica. La disponibilidad de mas de cien caracteristicas diferentes de las cepas, aportadas desde diversos puntos de Europa y reunidas por Campynet, es una herramienta indispensable para conseguir este objetivo.
Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort
Authors: Louise G. Grunnet, Susanne Hansen, Line Hjort, Camilla M. Madsen, Freja B. Kampmann, Anne Cathrine B. Thuesen, Charlotta Granstrømi, Marin Strøm, Ekaterina Maslova, Ruth Frikke-Schmidt, Peter Damm, Jorge E. Chavarro, Frank B. Hu, Sjurdur F. Olsen, Allan Vaag
Journal: Diabetes Care (2017)

OBJECTIVE Offspring of pregnancies affected by gestational diabetes mellitus (GDM) are at increased risk of the development of type 2 diabetes. However, the extent to which these dysmetabolic traits may be due to offspring and/or maternal adiposity is unknown. We examined body composition and associated cardiometabolic traits in 561 9- to 16-year-old offspring of mothers with GDM and 597 control offspring. RESEARCH DESIGN AND METHODS We measured anthropometric characteristics; puberty status; blood pressure; and fasting glucose, insulin, C-peptide, and lipid levels; and conducted a DEXA scan in a subset of the cohort. Differences in the outcomes between offspring of mothers with GDM and control subjects were examined using linear and logistic regression models. RESULTS After adjustment for age and sex, offspring of mothers with GDM displayed higher weight, BMI, waist-to-hip ratio (WHR), systolic blood pressure, and resting heart rate and lower height. Offspring of mothers with GDM had higher total and abdominal fat percentages and lower muscle mass percentages, but these differences disappeared after correction for offspring BMI. The offspring of mothers with GDM displayed higher fasting plasma glucose, insulin, C-peptide, HOMA-insulin resistance (IR), and plasma triglyceride levels, whereas fasting plasma HDL cholesterol levels were decreased. Female offspring of mothers with GDM had an earlier onset of puberty than control offspring. Offspring of mothers with GDM had significantly higher BMI, WHR, fasting glucose, and HOMA-IR levels after adjustment for maternal prepregnancy BMI, and glucose and HOMA-IR remained elevated in the offspring of mothers with GDM after correction for both maternal and offspring BMIs. CONCLUSIONS In summary, adolescent offspring of women with GDM show increased adiposity, an adverse cardiometabolic profile, and earlier onset of puberty among girls. Increased fasting glucose and HOMA-IR levels among the offspring of mothers with GDM may be explained by the programming effects of hyperglycemia in pregnancy.
TCT-228 Early neointimal coverage of new biodegradable polymer drug-eluting stent compared with durable polymer everolimus-eluting stent: optical frequency domain imaging analysis
Authors: Norihiro Kobayashi, Yoshiaki Ito, Keisuke Hirano, Masahiro Yamawaki, Motoharu Araki
Journal: Journal of the American College of Cardiology (2017)
Risk Factor Analyses of Severe Cicatricial Stricture after Chemoradiotherapy for Stage II/III (T3) Esophageal Carcinoma
Authors: Natsuko Kitamura (Tsushita), Yoshitaka Honma, Kengo Nagashima, Hirokazu Shoji, Atsuo Takashima, Satoru Iwasa, Ken Kato, Tetsuya Hamaguchi, Jun Itami, Narikazu Boku
Journal: Annals of Oncology (2017)
Abstract 13698: Comparative Long-term Outcomes of Endovascular versus Open Revascularization for Lower Extremity Peripheral Arterial Disease
Authors: Jason T Wiseman, Sara Fernandes-Taylor, Sandeep Saha, Jeffrey Havlena, Paul J Rathouz, Maureen A Smith, K. Craig Kent
Journal: Circulation (2015)

Introduction: Restoring circulation to patients with symptomatic lower extremity peripheral arterial disease (PAD) is traditionally achieved with open surgery. However, endovascular techniques have enhanced the armamentarium available to patients. No long-term, population-based results exist on which of these provides the optimal approach to symptomatic PAD. Methods: We identified patients who underwent an inpatient endovascular or open lower extremity revascularization for PAD (including those with claudication and limb threat) for 2006 through 2009 from the Centers for Medicare &amp; Medicaid Services Chronic Conditions Warehouse, a 5% national sample of Medicare beneficiaries. The primary outcome was amputation free survival. The secondary outcome was the relative rate of subsequent intervention. Propensity score matching ensured similar baseline characteristics amongst cohorts. Results: Among 14,685 eligible patients, 5,928 endovascular revascularization patients and 5,928 open revascularization patients were included in a matched analysis. Patients undergoing endovascular repair had improved amputation free survival compared to open repair at 30-days (7.4 vs. 8.9%, p=0.002). This benefit persisted over the long-term: At 4-years, 49% of endovascular patients had died or received major amputation compared to 54% of open patients (p&lt;0.001). An endovascular procedure was associated with a risk-adjusted 19% decreased risk of amputation or death compared to open over the study period (hazard ratio: 0.84; 95% confidence interval, 0.79-0.89; p&lt;0.001). The rate of subsequent intervention at 30-days was 7.4% greater for the endovascular versus the open revascularization cohort. At 4-years, this difference remained stable at 8.6%. Conclusions: Using a population-based dataset, we show that an endovascular approach is associated with improved amputation free survival over the long-term. Moreover, we show a modest initial increase in the risk of reintervention after endovascular procedures; the differential rate of reintervention for endovascular patients was less than 10% over four years. The observed benefit associated with endovascular intervention may have significant implications for the millions of patients with PAD.
Recommandations européennes pour la prévention de la légionellose : l'expérience italienne
Authors: M C Rota, M R Caporali, M Massari
Journal: Eurosurveillance (2004)

En Italie, 35 foyers le legionellose associee aux voyages ont ete identifies entre juillet 2002, date de l'adoption des recommandations europeennes sur la surveillance de la legionellose par le reseau EWGLINET, et octobre 2003. Huit (28,6%) d'entre eux n'auraient pas pu etre detectes sans le reseau. 
Les foyers identifies etaient de petite taille, allant de deux a six cas maximum et representaient un total de 87 patients. Cinq campings et 30 hotels/residences etaient impliques. Le diagnostic, confirme pour 92,0% des cas, a ete realise principalement par detection de l'antigene urinaire (84,7%). Une souche clinique etait disponible pour un cas seulement. 
Suite aux investigations environnementales, des prelevements ont ete recueillis pour les 35 foyers a partir des systeme hydrauliques. Legionella pneumophila a ete identifie dans 23 cas (65,7%). Sur les 35 sites, les investigations etaient en cours sur 15 sites au moment de la declaration des foyers a EWGLI. Cela s'explique par le fait qu'en Italie, l'investigation environnementale debute des la declaration d'un cas unique. Des mesures de controle ont ete mises en place dans tous les sites a risque et seul un hotel a ete ferme. 
Des rapports ont ete completes et envoyes dans les temps pour les 35 foyers, ce qui prouve qu'il est possible de respecter les procedures exigees par les recommandations europeennes.
Inference in Psychiatry via 2-Sample Mendelian Randomization—From Association to Causal Pathway?
Authors: Enda M. Byrne, Jian Yang, Naomi R. Wray
Journal: JAMA Psychiatry (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal