FRI0553 The role of age-related sarcopenia in osteoarthritis of lower extremity
Authors: Y. Safonova, E. Zotkin
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Sarcopenia, defined as the age-related loss of muscle mass and low muscle function.<sup>1</sup> The prevalence of sarcopenia worldwide by meta-analysis of 35 articles was 10% (95% CI: 8%–12%) in men and 10% (95% CI: 8%–13%) in women, respectively.<sup>2</sup> A review of the literature on osteoarthritis (OA) and sarcopenia has shown that the age factor that contributes to the development of OA includes a decrease in muscle strength. In people with OD of the lower extremity, the frequency of falls was increased by a factor of 2–5.<sup>3</sup> OA contributed to the development of sarcopenia in elderly women.<sup>4</sup> <h3>Objectives</h3> Perform body composition and muscle analysis in patients with osteoarthritis and identify risk factors for sarcopenia that affect patients with osteoarthritis. <h3>Methods</h3> Prospective study of 159 women, mean age 74±13.3. The walking speed, handgrip strength were evaluated to apply the European Working Group on Sarcopenia. Assessment of appendicular skeletal muscle mass (ALM/h<sup>2</sup>) and total body fat were assessed using DXA, on Hologic Explorer machines. Covariates were determined by questionnaires and interviews. <h3>Results</h3> 31.45% of people with OA older than 65 years had sarcopenia. Patients with OA had a decrease in muscle strength and function, regardless of sarcopenia. Statistically significantly more frequent in patients with OA were lower indexes of lean mass index (ALM/h<sup>2</sup>) and body mass index (BMI) (p&lt;0.01). The incidence of sarcopenia increased with age (p&lt;0.01). 61.5% of patients with sarcopenia significantly more often had high values of c-reactive protein – CRP (x<sup>2</sup>=31.18, p&lt;0.0001). Patients with sarcopenia were statistically significantly more likely to have vitamin D deficiency than patients without sarcopenia (x<sup>2=</sup>8.11, p&lt;0.01). Cases of falls were observed in 90% of patients with sarcopenia (x<sup>2=</sup>79.29, p&lt;0.001). Low physical activity 86% of patients with sarcopenia are statistically significantly higher than in patients without sarcopenia (95% CI: 73.3–94.2, p&lt;0.01). <h3>Conclusions</h3> With age, patients with sarcopenia and OA had a significant decrease in muscle mass and physical activity, an increase in the incidence of falls. Patients with sarcopenia had high CRP levels and vitamin D deficiency than patients without sarcopenia. <h3>References</h3> [1] Milte R, Crotty M. Musculoskeletal health, frailty and functional decline. Best Pract Res Clin Rheumatol. 2014;28(3):395–410. [2] Shafiee G, Keshtkar A, Soltani A, et al. Prevalence of sarcopenia in the world: a systematic review and meta- analysis of general population studies. Journal of Diabetes &amp; Metabolic Disorders2017;16:21. [3] Hoops ML, Rosenblatt NJ, Hurt CP, Crenshaw J, Grabiner MD. Does lower extremity osteoarthritis exacerbate risk factors for falls in older adults?Womens Health (Lond Engl)2012;8(6):685–96. [4] Kemmler W, Teschler M, Goisser S, Et al. Prevalence of sarcopenia in germany and the corresponding effect of osteoarthritis in females 70 years and older living in the community: results of the FOrMosA study. Clinical Interventions in Aging2015;10:1565–1573. <h3>Disclosure of Interest</h3> None declared