tbuckley/cabot-search huggingface dataset:
Impact of the 2013 National Rollout of CMS Competitive Bidding Program: The Disruption Continues
Authors: Gary A. Puckrein, Irl B. Hirsch, Christopher G. Parkin, Bruce T. Taylor, Liou Xu, David G. Marrero
Journal: Diabetes Care (2017)

OBJECTIVE Use of glucose monitoring is essential to the safety of individuals with insulin-treated diabetes. In 2011, the Centers for Medicare &amp; Medicaid Services (CMS) implemented the Medicare Competitive Bidding Program (CBP) in nine test markets. This resulted in a substantial disruption of beneficiary access to self-monitoring of blood glucose (SMBG) supplies and significant increases in the percentage of beneficiaries with either reduced or no acquisition of supplies. These reductions were significantly associated with increased mortality, hospitalizations, and costs. The CBP was implemented nationally in July 2013. We evaluated the impact of this rollout to determine if the adverse outcomes seen in 2011 persisted. RESEARCH DESIGN AND METHODS This longitudinal study followed 529,627 insulin-treated beneficiaries from 2009 through 2013 to assess changes in beneficiary acquisition of testing supplies in the initial nine test markets (TEST, n = 43,939) and beneficiaries not affected by the 2011 rollout (NONTEST, n = 485,688). All Medicare beneficiary records for analysis were obtained from CMS. RESULTS The percentages of beneficiaries with partial/no SMBG acquisition were significantly higher in both the TEST (37.4%) and NONTEST (37.6%) groups after the first 6 months of the national CBP rollout, showing increases of 48.1% and 60.0%, respectively (both P &amp;lt; 0.0001). The percentage of beneficiaries with no record for SMBG acquisition increased from 54.1% in January 2013 to 62.5% by December 2013. CONCLUSIONS Disruption of beneficiary access to their prescribed SMBG supplies has persisted and worsened. Diabetes testing supplies should be excluded from the CBP until transparent, science-based methodologies for safety monitoring are adopted and implemented.
False positive serum levels of (1–3)-ß-D-Glucan after infusion of intravenous immunoglobulins and time to normalisation
Authors: M. Egger, F. Prüller, R. Raggam, M.K. Divjak, S. Kurath-Koller, H. Lackner, C. Urban, V. Strenger
Journal: Journal of Infection (2017)
Acute Chest Pain in the Emergency Department
Authors: Gregory Curfman
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The Supreme Court Ruling in <i>Sandoz v Amgen</i>
Authors: Ameet Sarpatwari, Abbe R. Gluck, Gregory D. Curfman
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Noninvasive Cardiac Testing vs Clinical Evaluation Alone in Acute Chest Pain
Authors: Samuel W. Reinhardt, Chien-Jung Lin, Eric Novak, David L. Brown
Journal: JAMA Internal Medicine (2017)

IMPORTANCEThe incremental benefit of noninvasive testing in addition to clinical evaluation (history, physical examination, an electrocardiogram [ECG], and biomarker assessment) vs clinical evaluation alone for patients who present to the emergency department (ED) with acute chest pain is unknown.OBJECTIVE To examine differences in outcomes with clinical evaluation and noninvasive testing (coronary computed tomographic angiography [CCTA] or stress testing) vs clinical evaluation alone. DESIGN, SETTING, AND PARTICIPANTSThis study was a retrospective analysis of data from the randomized multicenter Rule Out Myocardial Ischemia/Infarction by Computer Assisted Tomography (ROMICAT-II) trial.Data for 1000 patients who presented with chest pain to the EDs at 9 hospitals in the United States were evaluated. INTERVENTIONS Clinical evaluation plus noninvasive testing (CCTA or stress test) vs clinical evaluation alone.MAIN OUTCOMES AND MEASURES Primary outcome was length of stay (LOS).Secondary outcomes included hospital admission, direct ED discharge, downstream testing, rates of invasive coronary angiography, revascularization, major adverse cardiac events (MACE), repeated ED visit or hospitalization for recurrent chest pain at 28 days, and cost.Safety end points were missed acute coronary syndrome (ACS) and cumulative radiation exposure during the index visit and follow-up period. RESULTSOf the 1000 patients randomized, 118 patients (12%) (mean [SD] age, 53.2 [7.8]; 49 [42%] were female) did not undergo noninvasive testing, whereas 882 (88%) (mean [SD] age, 54.4 [8.14] years; 419 [48%] were female) received CCTA or stress testing.There was no difference in baseline characteristics or clinical presentation between groups.Patients who underwent clinical evaluation alone experienced a shorter LOS (20.3 vs 27.9 hours; P < .001),lower rates of diagnostic testing (P < .001)and angiography (2% vs 11%; P < .001),lower median costs ($2261.50vs $2584.30;P = .009),and less cumulative radiation exposure (0 vs 9.9 mSv; P < .001)during the 28-day study period.Lack of testing was associated with a lower rate of diagnosis of ACS (0% vs 9%; P < .001)and less coronary angiography and percutaneous coronary intervention (PCI) during the index visit (0% vs 10%; P < .001,and 0% vs 4%; P = .02,respectively).There was no difference in rates of PCI (2% vs 5%; P = .15),coronary artery bypass surgery (0% vs 1%; P = .61),return ED visits (5.8% vs 2.8%; P = .08),or MACE (2% vs 1%; P = .24)in the 28-day follow-up period. CONCLUSIONS AND RELEVANCEIn patients presenting to the ED with acute chest pain, negative biomarkers, and a nonischemic ECG result, noninvasive testing with CCTA or stress testing leads to longer LOS, more downstream testing, more radiation exposure, and greater cost without an improvement in clinical outcomes.
Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells
Authors: Dimitris Karamitros, Bilyana Stoilova, Zahra Aboukhalil, Fiona Hamey, Andreas Reinisch, Marina Samitsch, Lynn Quek, Georg Otto, Emmanouela Repapi, Jessica Doondeea, Batchimeg Usukhbayar, Julien Calvo, Stephen Taylor, Nicolas Goardon, Emmanuelle Six, Francoise Pflumio, Catherine Porcher, Ravindra Majeti, Berthold Göttgens, Paresh Vyas
Journal: Nature Immunology (2017)
The association between atopic dermatitis and hand eczema: a systematic review and meta-analysis
Authors: S.M.D. Ruff, K.A. Engebretsen, C. Zachariae, J.D. Johansen, J.I. Silverberg, A. Egeberg, J.P. Thyssen
Journal: British Journal of Dermatology (2017)

Atopic dermatitis (AD) and hand eczema (HE) are common chronic and relapsing inflammatory skin conditions that often co-occur.While several studies have addressed their relationship, the exact association estimate is unknown.We systematically reviewed published literature on the association between AD and HE in PubMed, Embase and Web of Science using the following search terms: (atopic dermatitis OR atopic eczema) AND (hand dermatitis OR hand eczema). Meta-analyses were then performed to examine the association between AD and the point, 1-year and lifetime prevalence of HE, respectively.We identified 35 relevant studies, of which 26 were included in the meta-analyses. AD was associated with an increased prevalence of HE with regard to point [odds ratio (OR) 2·35; 95% confidence interval (CI) 1·47-3·76], 1-year (OR 4·29; 95% CI 3·13-5·88) and lifetime prevalence (OR 4·06; 95% CI 2·72-6·06). Furthermore, positive associations between AD and occupational HE were identified when assessing the 1-year (OR 4·31; 95% CI 2·08-8·91) and lifetime prevalence (OR 2·81; 95% CI 2·08-3·79). Similar positive associations were found in the general population studies, i.e. OR 4·19 (95% CI 3·46-5·08) and OR 5·69 (95% CI 4·41-7·36).Important study limitations include the wide use of questionnaire studies, and lack of prospective studies as well as poor clinical phenotype descriptions. In conclusion, our systematic review and meta-analysis showed that patients with AD had a strongly increased prevalence of HE. Clinicians should continue to guide patients with AD away from occupations with a high risk of HE.
Abstract 21415: Use of High Power Radiofrequency versus Low Power for Ablation of Atrial Fibrillation: Feasibility and Safety
Authors: Mobin Kheirkhahan, Alex Baher, Johannes Siebermair, Stephen Rechenmacher, Gagandeep Kaur, Benjamin A Steinberg, Mihail G Chelu, Frederick T Han, Nassir F Marrouche
Journal: Circulation (2017)

Introduction: Radiofrequency Catheter ablation (RFCA) has become an established strategy to treat symptomatic and drug refractory cases of Atrial Fibrillation (AF). Despite its safety, RFCA accompanies some serious complications such as esophageal thermal damage, that makes physicians more cautious while ablating the posterior structures and avoid using higher powers for RFCA. Hypothesis: We aim to investigate the safety of 50 watts RFCA compared with 35 watts, by the novel method of detecting any esophageal enhancement with Late Gadolinium Enhancement MRI (LGE-MRI). Methods: Records of 511 AF patients from 2012 to 2016 were collected; who underwent RFCA and had LGE-MRI post-ablation to detect any esophageal injury. The method of ablation for both groups includes Pulmonary Vein Isolation (PVI) and Posterior Wall Debulking (PWD). Patients were categorized into 2 groups: The High Power (HP) group who underwent ablation with 50 Watts catheters and the Low Power (LP) group, for whom the 35 Watts catheters were used. With regard to their respective esophageal enhancement, patients were classified as those who had no, mild, moderate, or significant esophageal enhancement. Results: There were 459 patients in HP group (301 men; mean age 70.4 ± 11.2) and 52 patients in LP group (32 male; mean age 64.1 ± 11.7). HP group was significantly older (p &lt; 0.05) and persistent type of AF was more common among them (51.5% vs 25%, p &lt; 0.05). The incidence of esophageal enhancement post-ablation was not significantly different among HP and LP groups (Figure 1) but the procedure time was significantly shorter for HP group (149.3 ± 64.8 minutes vs 308.4 ± 104, p &lt; 0.001). None of our patients (in both groups) developed serious complications such as atrioesophageal fistula. Conclusions: Using high power radiofrequency catheter ablation for AF patients shows no correlation with esophageal enhancement post-PWD ablation, furthermore they can significantly reduce the procedure time.
Genomic profiling for advanced non-small-cell lung cancer (NSCLC) from circulating tumour DNA (ctDNA)
Authors: H. Loong, V. Raymond, D.T.T. Chua, P.M.L. Teo, T. Yung, R.B. Lanman, S. Skrzypczak, T.S.K. Mok
Journal: Annals of Oncology (2017)
Abstract 13055: Cardiac Structure and Function in US Latinos of Diverse Backgrounds With and Without the Metabolic Syndrome: The Echocardiographic Study of Latinos (Echo-SOL)
Authors: Melissa Burroughs Peña, Katrina Swett, Neil Scheiderman, Daniel M Spevack, Sonia G Ponce, Gregory A Talavera, Mayank M Kansal, Martha Daviglus, Jianwen Cai, Barry E Hurwitz, Maria M Llabre, Carlos J Rodriguez
Journal: Circulation (2016)

Background: Hispanics/Latinos with heart failure are younger with more co-morbidities compared to non-Hispanic whites, yet the role of metabolic syndrome (MetS) as a risk factor for cardiac dysfunction in this population has not been well described. Methods: This is a cross-sectional analysis of Echo-SOL, a population-based cohort of 1818 US Hispanics/Latinos. Nondiabetic participants without coronary artery disease or severe valve disease were included. MetS was defined by the AHA/NHLBI 2009 Joint Scientific Statement. Survey multivariable linear regression analyses using sampling weights were used to model the relationship between MetS and echocardiographic measures of cardiac structure and function, adjusting for covariates (age, sex, study site, tobacco use, alcohol use, physical activity, years of education). Additionally, individuals with a body mass index (BMI) &lt;25 without MetS were compared with the following: BMI&lt;25/ +MetS; BMI&gt;25/ -MetS; and BMI&gt;25/+MetS. Results: Among 1260 nondiabetics (59% female) high waist circumference and elevated triglycerides were associated with worse GLS; high waist circumference and elevated blood pressure were associated with higher left ventricular mass index and worse E/E’ ratio. Compared with individuals without MetS, individuals with MetS had lower medial and lateral E’ velocities (-0.4 cm/s, [Standard Error 0.1], p=0.0002; -0.5 cm/s [0.2], p=0.02, respectively), greater E/E’ (0.5 [0.2], p=0.01), and worse 2-chamber global longitudinal strain (GLS) (0.9%, SE 0.3, p=0.009). Individuals with BMI&lt;25/ +MetS (N=22) had the greatest reduction in left ventricular function with worse 4-chamber, 2-chamber and average GLS (2.1% [0.9], p=0.02; 2.3% [0.7], p=0.001; 2.3% [0.7], p=0.002, respectively), reduced medial and lateral E’ velocities (-1.7cm/s [0.4], p&lt;0.0001; -1.6cm/s [0.5, p=0.002], respectively) and lower ejection fraction (-3.5% [1.4], p=0.007) compared with those with a BMI &lt;25 without MetS. Conclusions: In a sample of US Hispanics/Latinos, MetS was associated with worse left ventricular systolic and diastolic function, even among normal weight individuals.
Induction of growth inhibition and apoptosis by TZD18, a novel dual ligand for PPARα/γ, in human breast cancer cells in vitro
Authors: Chuanbing Zang, Hongyu Liu, Maren Mieth, Janina Bertz, Kurt Possinger, Elena Elstner
Journal: Cancer Research (2006)

4645   We and other researchers have frequently shown that the thiazolidinedione (TZD) class of anti-diabetic drugs, which are specific ligands for peroxisome proliferator-activated receptor gamma (PPARγ), inhibited proliferation, tumor invasion and induced apoptosis in human breast cancer both  in vitro  and  in vivo . However, in several clinical trials, these PPARγ ligands, such as pioglitazone, rosiglitazone and troglitazone, showed no or only minimal benefit on breast cancer patients. One of the reasons might be due to the moderate anticancer activities of these substances. In this study, we tested the effects of a novel dual ligand specific for PPARα/γ, TZD18 (MERCK, NJ, USA) on six human breast cancer cell lines. We found that TZD18 inhibited proliferation, induced differentiation and apoptosis of all human breast cancer cell lines tested with different sensitivity. These effects were much stronger than these of the classic antidiabetic glitazones. However, these effects seemed not to be mediated, at least in part, through activation of PPARα or PPARγ, since knockdown of PPARα and/or γ by siRNA had only a minimal influence on these effects. A G1 cell cycle arrest has been observed which was associated with upregulation of cyclin dependent kinase inhibitor p27 kip1  and downregulation of cyclins (D2 and E), and cyclin dependent kinases (2 and 4). A microarray analysis with the aim to identify the mechanism underlying the TZD18 induced apoptosis of breast cancer cells revealed several new apoptosis mediators which were not linked to PPARγ ligand induced apoptosis before. A verification of these data is in process in our laboratory. Overall, our findings strongly suggest that TZD18 may offer a new therapeutic agent for treatment of human breast cancers in an adjuvant setting.
A role for bacterial urease in gut dysbiosis and Crohn’s disease
Authors: Josephine Ni, Ting-Chin David Shen, Eric Z. Chen, Kyle Bittinger, Aubrey Bailey, Manuela Roggiani, Alexandra Sirota-Madi, Elliot S. Friedman, Lillian Chau, Andrew Lin, Ilana Nissim, Justin Scott, Abigail Lauder, Christian Hoffmann, Gloriany Rivas, Lindsey Albenberg, Robert N. Baldassano, Jonathan Braun, Ramnik J. Xavier, Clary B. Clish, Marc Yudkoff, Hongzhe Li, Mark Goulian, Frederic D. Bushman, James D. Lewis, Gary D. Wu
Journal: Science Translational Medicine (2017)

Bacterial urease activity of the gut microbiota alters nitrogen flux, leading to gut dysbiosis and worsening of colitis in mice.
Abstract 16084: Sexual Activity as a Trigger for Sudden Cardiac Death
Authors: Aapo Aro, Carmen Rusinaru, Audrey Uy-Evanado, Harpriya Chugh, Kyndaron Reinier, Eric Stecker, Jonathan Jui, Sumeet S Chugh
Journal: Circulation (2017)

Background: Sexual activity is an important aspect of quality of life, and is associated with health and mortality benefit. However, sexual activity may also act as a trigger of acute coronary even...
Preparación para una epidemia de gripe en Italia: recursos y procedimientos en las unidades de pediatría hospitalarias
Authors: V Giacomet, L Tarallo, G De Marco, A Giannattasio, A Barbarino, A Guarino
Journal: Eurosurveillance (2007)

La Organizacion Mundial de la Salud (OMS) ha declarado que la preparacion para hacer frente a una gran epidemia de gripe debe abarcar la formacion del personal medico en el tratamiento de las enfermedades infecciosas y la modernizacion de los procedimientos y recursos hospitalarios.
Abstract 18940: Pre-B-Cell Colony Enhancing Factor Blood Levels Correlate With Intravenous Catecholamine Use and Post-Resuscitation Death After Out-of-Hospital Cardiac Arrest
Authors: Jing Li, Wei Zhang, Xiangdong Zhu, Chunpei Lee, Mary A Peberdy, Terry L Vanden Hoek
Journal: Circulation (2016)

Introduction:  High blood concentrations of the cytokine PBEF are associated with poor cardiac arrest outcomes in our prior animal studies. Furthermore, PBEF release results from high energy demands as occur with surges of catecholamine, and can cause cardiac dysfunction and up-regulation of other pro-inflammatory cytokines similar to that seen after human cardiac arrest.   Hypothesis:  PBEF level is associated with cardiac arrest survival and intravenous catecholamine (i.e. CAT) administration.   Methods:  Prospective, observational cohort study of 81 out-of-hospital cardiac arrest (OHCA) patients was performed at four geographically distinct urban tertiary care cardiac arrest centers of excellence from 2011 to 2012. Hypothermia (33°C) was applied to all patients. Intravenous CAT was administered per resuscitation protocols. Serial blood samples were taken at time of admission and through 48 h after admission (T0, T12, T24, T36 and T48 respectively). Survival and discharge outcomes with neurological score were evaluated.   Results:  75 patients had CAT administration and 36 patients did not. 25 out of 75 patients who received intravenous CAT survived. By contrast, 26 out of the 36 patients without CAT administration survived. Chi-square testing shows a strong association (33.3% vs. 72.2%, p=0.00012) between CAT treatment and death. A trend of high blood PBEF levels was observed throughout T0 to T48 with the T12 and T24 post-resuscitation time-points being most significant (p   Conclusion:  High blood PBEF levels and catecholamine administration are independently associated with post-resuscitation death in OHCA patients. Future work is needed to understand whether PBEF may an important mediator of catecholamine-induced post-resuscitation injury.
Public health interventions can increase objective and perceived control by supporting people to enact the choices they want to make
Authors: Jean Adams
Journal: Behavioral and Brain Sciences (2017)

Abstract “Low-agency” public health interventions do not rely on individuals using their personal resources to benefit. These help people enact the choices they wish to make and are likely to increase objective and perceived control. Lower-agency interventions have been criticised as constraining individual choice. Pepper &amp; Nettle show that this is unlikely to be the case.
Overall survival in the FOXFIRE-SIRFLOX-FOXFIRE global prospective randomized studies of first-line SIRT in patients with mCRC
Authors: H. Wasan, G. van Hazel, V. Heinemann, N. Sharma, J. Taieb, J. Ricke, M. Peeters, M. Findlay, P. Virdee, S.B. Love, J. Moschandreas, P. Dutton, V. Gebski, A. Gray, R. Sharma, P. Gibbs
Journal: Annals of Oncology (2017)
Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance
Authors: Keiji Tanigaki, Anastasia Sacharidou, Jun Peng, Ken L. Chambliss, Ivan S. Yuhanna, Debabrata Ghosh, Mohamed Ahmed, Alexander J. Szalai, Wanpen Vongpatanasin, Robert F. Mattrey, Qiushi Chen, Parastoo Azadi, Ildiko Lingvay, Marina Botto, William L. Holland, Jennifer J. Kohler, Shashank R. Sirsi, Kenneth Hoyt, Philip W. Shaul, Chieko Mineo
Journal: Journal of Clinical Investigation (2017)

Type 2 diabetes mellitus (T2DM) is a common complication of obesity. Here, we have shown that activation of the IgG receptor FcγRIIB in endothelium by hyposialylated IgG plays an important role in obesity-induced insulin resistance. Despite becoming obese on a high-fat diet (HFD), mice lacking FcγRIIB globally or selectively in endothelium were protected from insulin resistance as a result of the preservation of insulin delivery to skeletal muscle and resulting maintenance of muscle glucose disposal. IgG transfer in IgG-deficient mice implicated IgG as the pathogenetic ligand for endothelial FcγRIIB in obesity-induced insulin resistance. Moreover, IgG transferred from patients with T2DM but not from metabolically healthy subjects caused insulin resistance in IgG-deficient mice via FcγRIIB, indicating that similar processes may be operative in T2DM in humans. Mechanistically, the activation of FcγRIIB by IgG from obese mice impaired endothelial cell insulin transcytosis in culture and in vivo. These effects were attributed to hyposialylation of the Fc glycan, and IgG from T2DM patients was also hyposialylated. In HFD-fed mice, supplementation with the sialic acid precursor N-acetyl-D-mannosamine restored IgG sialylation and preserved insulin sensitivity without affecting weight gain. Thus, IgG sialylation and endothelial FcγRIIB may represent promising therapeutic targets to sever the link between obesity and T2DM.