Bone Health and Bone-Targeted Therapies for Nonmetastatic Prostate Cancer
Authors: Shabbir M.H. Alibhai, Katherine Zukotynski, Cindy Walker-Dilks
Journal: Annals of Internal Medicine (2018)

Letters20 March 2018Bone Health and Bone-Targeted Therapies for Nonmetastatic Prostate CancerShabbir M.H. Alibhai, MD, MSc, Katherine Zukotynski, MD, and Cindy Walker-Dilks, MLSShabbir M.H. Alibhai, MD, MScUniversity of Toronto, Toronto, Ontario, Canada (S.M.A.), Katherine Zukotynski, MDMcMaster University, Hamilton, Ontario, Canada (K.Z., C.W.), and Cindy Walker-Dilks, MLSMcMaster University, Hamilton, Ontario, Canada (K.Z., C.W.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0702 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Strum contends that quantitative computed tomography has several advantages over dual x-ray absorptiometry in the diagnosis of osteoporosis. Although we agree (1), quantitative computed tomography is substantially more expensive and we are unaware of any controlled data showing its advantage in improving such outcomes as fracture prevention. Current guidelines thus do not routinely recommend this study to detect or monitor bone loss in patients with cancer (2).Dr. Strum cites interesting data on various bone turnover markers, including serum tartrate-resistant acid phosphatase 5β, as indicators of osteoclast activity in patients with several types of cancer. We agree ...References1. Link TM. Osteoporosis imaging: state of the art and advanced imaging. Radiology. 2012;263:3-17. [PMID: 22438439] doi:10.1148/radiol.12110462 CrossrefMedlineGoogle Scholar2. Gralow JR, Biermann JS, Farooki A, Fornier MN, Gagel RF, Kumar R, et al. NCCN Task Force report: bone health in cancer care. J Natl Compr Canc Netw. 2013;11 Suppl 3:S1-50. [PMID: 23997241] CrossrefMedlineGoogle Scholar3. Datta M, Schwartz GG. Calcium and vitamin D supplementation during androgen deprivation therapy for prostate cancer: a critical review. Oncologist. 2012;17:1171-9. [PMID: 22836449] CrossrefMedlineGoogle Scholar4. Alibhai SMH, Zukotynski K, Walker-Dilks C, Emmenegger U, Finelli A, Morgan SC, et al; Cancer Care Ontario Genitourinary Cancer Disease Site Group. Bone health and bone-targeted therapies for prostate cancer: a programme in evidence-based care—Cancer Care Ontario clinical practice guideline. Clin Oncol (R Coll Radiol). 2017;29:348-55. [PMID: 28169118] doi:10.1016/j.clon.2017.01.007 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Toronto, Toronto, Ontario, Canada (S.M.A.)McMaster University, Hamilton, Ontario, Canada (K.Z., C.W.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-2577. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBone Health and Bone-Targeted Therapies for Nonmetastatic Prostate Cancer Shabbir M.H. Alibhai , Katherine Zukotynski , Cindy Walker-Dilks , Urban Emmenegger , Antonio Finelli , Scott C. Morgan , Sebastién J. Hotte , George A. Tomlinson , and Eric Winquist Bone Health and Bone-Targeted Therapies for Nonmetastatic Prostate Cancer Stephen B. Strum Metrics Cited byBone health management in the continuum of prostate cancer disease: a review of the evidence with an expert panel opinionManagement of Metastatic Hormone-Sensitive Prostate Cancer (mHSPC): an Evolving Treatment Paradigm 20 March 2018Volume 168, Issue 6Page: 459-460KeywordsBone remodelingCalciumComputed axial tomographyDisclosureOsteoclastsOsteoporosisPhoton absorptiometryProstate cancerSystematic reviewsVitamin D ePublished: 20 March 2018 Issue Published: 20 March 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...