tbuckley/cabot-search huggingface dataset:
Endothelial dysfunction and increased platelet reactivity in patients with acute coronary syndrome and undiagnosed COPD: insights into the SCAP trial
Authors: Rita Pavasini, Francesco Vieceli dalla Sega, Francesco Gallo, Giulia Passarini, Alberto Papi, Marco Contoli, Gianluca Campo
Journal: European Respiratory Journal (2017)

Unknown/undiagnosed chronic obstructive pulmonary disease (UCOPD) frequently coexists and negatively impacts in the short- and long-term prognosis of patients with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI) [1]. In the Screening for COPD in Acute coronary syndromes Patients (SCAP) trial [2], we recently showed that COPD is frequently undiagnosed in ccute coronary syndrome (ACS) patients with smoking history. Furthermore, we found that a simple screening procedure including peak expiratory flow measurement and respiratory health status questionnaire (RHSQ) might be administered before hospital discharge to discriminate those at risk of UCOPD. In the SCAP study, it was pre-specified that an ancillary analysis aimed to clarify if UCOPD was related to abnormalities in platelet reactivity and endothelial function. Endothelial dysfunction and increased platelet reactivity in acute coronary syndrome with unknown/undiagnosed COPD <http://ow.ly/SVEg30eExbK> Author contributions are as follows. R. Pavasini is the guarantor of the content of the manuscript, including the data and analysis. R. Pavasini, G. Campo, F. Vieceli dalla Sega: conception, design, analysis and interpretation of data. R. Pavasini, G. Campo, M. Contoli, A. Papi: data analysis and interpretation. All authors: drafting of the manuscript and revising it critically for important intellectual content. All authors: final approval of the manuscript submitted.
GW28-e1134 CREG modulates Angiotensin II type 1 receptor to antagonize coronary oxidative stress and hypertension in salt-sensitive rats
Authors: Yujie Zhang, Xin Zhao, Chenghui Yan, Shaowei Liu, Nan Zhu, Xiaolin Zhang, Zhiming Zhu, Yaling Han, Wang Shuang
Journal: Journal of the American College of Cardiology (2017)
Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma
Authors: Martin Dreyling, Armando Santoro, Luigina Mollica, Sirpa Leppä, George A. Follows, Georg Lenz, Won Seog Kim, Arnon Nagler, Panayiotis Panayiotidis, Judit Demeter, Muhit Özcan, Marina Kosinova, Krimo Bouabdallah, Franck Morschhauser, Don A. Stevens, David Trevarthen, Marius Giurescu, Lisa Cupit, Li Liu, Karl Köchert, Henrik Seidel, Carol Peña, Shuxin Yin, Florian Hiemeyer, Jose Garcia-Vargas, Barrett H. Childs, Pier Luigi Zinzani
Journal: Journal of Clinical Oncology (2017)

Purpose Phosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K inhibitor with predominant activity against PI3K-α and -δ isoforms, has demonstrated efficacy and a manageable safety profile in patients with indolent lymphoma. Patients and Methods In this phase II study, 142 patients with relapsed or refractory indolent lymphoma after two or more lines of therapy were enrolled to receive copanlisib 60 mg intravenously on days 1, 8, and 15 of a 28-day cycle. The primary end point was objective response rate; secondary end points included duration of response, progression-free survival, and overall survival. In addition, safety and gene expression were evaluated. Results Median age was 63 years (range, 25 to 82 years), and patients had received a median of three (range, two to nine) prior regimens. The objective response rate was 59% (84 of 142 patients); 12% of patients achieved a complete response. Median time to response was 53 days. Median duration of response was 22.6 months, median progression-free survival was 11.2 months, and median overall survival had not yet been reached. The most frequent treatment-emergent adverse events were transient hyperglycemia (all grades, 50%; grade 3 or 4, 41%) and transient hypertension (all grades, 30%; grade 3, 24%). Other grade ≥3 events included decreased neutrophil count (24%) and lung infection (15%). High response rates to copanlisib were associated with high expression of PI3K/B-cell receptor signaling pathway genes. Conclusion PI3K-α and -δ inhibition by copanlisib demonstrated significant efficacy and a manageable safety profile in heavily pretreated patients with relapsed or refractory indolent lymphoma.
Phase I expansion of olaparib (PARP inhibitor) and AZD5363 (AKT inhibitor) in recurrent ovarian, endometrial and triple negative breast cancer
Authors: S. Westin, J. Litton, R. Williams, P. Soliman, M. Frumovitz, K. Schmeler, A. Jazaeri, A. Sood, K. Lu, S. Moulder, R. Murthy, A. Rodriguez, C. Samuel, L. Engerman, A. Cyriac, P. Rugman, J. Lindemann, E. McMurtry, G. Mills, R. Coleman
Journal: Annals of Oncology (2017)
Acupuncture for symptom reduction in myeloma patients undergoing hematopoietic stem cell transplantation: A randomized, sham-controlled trial.
Authors: Gary E. Deng, Sergio Giralt, David J. Chung, Heather Jolie Landau, Jonathan Siman, Benjamin Search, Marci Coleton, Emily Vertosick, Nathan Shapiro, Christine Chien, Xin Shelley Wang, Barrie R. Cassileth, Jun J. Mao
Journal: Journal of Clinical Oncology (2017)

8021 Background: Hematopoietic stem cell transplantation (HCT) is a potentially curative treatment for a number of hematologic malignancies, but is associated with a high symptom burden for patients. We conducted a randomized sham-controlled trial to evaluate the preliminary efficacy and safety of acupuncture as an integrative treatment for managing common symptoms during HCT. Methods: Adult patients with multiple myeloma undergoing high dose melphalan followed by autologous peripheral blood HCT were randomized to receive either true or sham acupuncture once daily for five days starting on the day after chemotherapy. Symptom burden was assessed with the MD Anderson Symptom Inventory (MDASI) at baseline, during transplantation, and at 15 and 30 days after transplantation. Results: Among 60 participants, symptoms that are significantly reduced by true acupuncture more than sham acupuncture at 15 days include the following: nausea, lack of appetite, and drowsiness (p = 0.042, 0.025, and 0.010, respectively). Patients receiving sham acupuncture were more likely to increase use of pain medication post-transplantation (odds ratio 5.31, p = 0.017). Acupuncture was well tolerated with few attributable adverse events. Conclusions: True acupuncture may prevent escalation of symptoms including nausea, lack of appetite, and drowsiness experienced by patients undergoing autologous HCT, and to reduce the use of pain medications. These findings need to be confirmed in a future definitive study. Clinical trial information: NCT01811862.
Different RNA expression profile defines prognosis in grade 1/2 neuroendocrine neoplasms of small intestine origin: The GETNE-NETSEQ study
Authors: J. Capdevila, F. Mancuso, S. Landolfi, F. Salva, C. Miguel, P. Jiménez-Fonseca, R. Garcia-Carbonero, C. López López, A. Casteras, T. Sauri Nadal, P. Nuciforo, A. Vivancos, I. Matos
Journal: Annals of Oncology (2017)
Press: How the media report medical errors
Authors: Trevor Jackson
Journal: BMJ (2001)

# How the media report medical errors {#article-title-2}

On the front page of London's Evening Standard of 14 February the face of 3 year old Najiyah Hussain, beside the headline “She was killed by a hospital,” looks the epitome of wronged innocence. The paper's principal focus is the human tragedy of Najiyah and of her family. There has been little time, and little space, for analysis. But we are told: “Police are investigating the incident and a doctor has been suspended.”

The facts seem obvious. Najiyah, “given laughing gas instead of oxygen,” was the victim of a mistake that you would not expect could happen in a modern health service. A victim, just like Wayne Jowett, who died on 2 February, a month after vincristine was injected into his spine instead of a vein at Queen's Medical Centre, Nottingham. And just like the 74 year old man who died at the Royal Sussex County Hospital, Brighton, after the wrong drug was administered during surgery on 7 February.

Yet mistakes of the kind that led to such deaths are not as …
Potential impact of the 4CMenB vaccine on oropharyngeal carriage of Neisseria meningitidis
Authors: Raquel Abad, Verónica Medina, Maria del Carmen Fariñas, Luis Martínez-Martínez, Stefania Bambini, A. Dari, Duccio Medini, Mariagrazia Pizza, Julio A. Vázquez
Journal: Journal of Infection (2017)
Screening Guidelines for Thyroid Function in Children With Alopecia Areata
Authors: Deepa Patel, Ping Li, Andrew J. Bauer, Leslie Castelo-Soccio
Journal: JAMA Dermatology (2017)

The incidence of thyroid disease in children with alopecia areata (AA) has been widely studied with no consensus on whether a true association with AA exists. In addition, screening practices for thyroid dysfunction in children with AA vary widely among clinicians.To reduce health care costs, eliminate unnecessary testing, and standardize clinical practices, we sought to characterize thyroid function in children with AA to establish guidelines for screening.A single-site retrospective medical chart review was carried out in an outpatient pediatric dermatology clinic in a tertiary referral medical center between January 1, 2008 and January 1, 2016. The study included 298 patients (ages 0-21 years) who received a clinical diagnosis of AA and underwent thyroid function tests.Age at diagnosis of AA, duration of disease, severity, location, and type were documented. Past medical history and family medical history of patients were also recorded. Results of laboratory tests including thyrotropin (formerly thyroid-stimulating hormone [TSH]), free T4 (FT4), triiodothyronine (T3), thyroid peroxidase antibodies (TPO-Abs), and thyroglobulin antibodies (Tg-Abs).During the 8-year period, 298 patients with AA had thyroid function screening. Of those with thyroid screening, patterns of AA included patchy (68%), ophiasis (13%), totalis (9%), and universalis (10%). Severity was determined by percentage of hair loss on the scalp and were divided into mild (30.2%), moderate (32.9%), and severe (36.9%). A total of 59 (20%) patients had abnormalities on thyroid testing results. In this group of patients, hypothyroidism was the most frequent finding 29 (49%), with Hashimoto thyroiditis being the most common cause(24 [41%]). Other abnormalities included hyperthyroidism secondary to Grave disease (12 [20%]) and subclinical thyroid dysfunction (7 [12%]). Whereas age, duration of disease, pattern of alopecia, and diagnosis of autoimmune diseases had no significant association with abnormal thyroid findings, a personal history of Down syndrome (P = .004), atopy (P = .009), and family history of thyroid disease (P = .001) did.We recommend that routine thyroid function screening should be restricted to AA patients with a medical history of Down syndrome, personal history of atopy, a family history of thyroid disease, or clinical findings (goiter) suggestive of potential thyroid dysfunction in the individual patient.
Phase II trial of S-1 treatment as palliative-intent chemotherapy for previously treated advanced thymic carcinoma
Authors: Y. Okuma, Y. Goto, F. Ohyanagi, K. Sunami, Y. Nakahara, S. Kitazono, Y. Tambo, N. Yanagitani, S. Kanda, H. Horinouchi, A. Horiike, Y. Fujiwara, H. Nokihara, N. Yamamoto, M. Nishio, Y. Ohe, Y. Hosomi
Journal: Annals of Oncology (2017)
Cognitive and contextual factors to optimise clinical outcomes in tendinopathy
Authors: Adrian James Mallows, James Robert Debenham, Peter Malliaras, Richmond Stace, Chris Littlewood
Journal: British Journal of Sports Medicine (2017)

Diaryliodonium salts are useful arylating reagents that have been exploited widely.In this Communication, we demonstrate that heating diphenyliodonium triflate in the solvent DMSO leads to an unexpected arylation reaction.It is postulated that arylation of DMSO at oxygen, followed by a thia-Sommelet-Hauser rearrangement, leads to the formation of 2-thiomethylphenols.More substituted diaryliodonium salts and cyclic diaryliodonium salts are shown to be more stable and less likely to react with DMSO.In conclusion, when using iodonium salts dissolved in DMSO, beware of side-reactions.
Arterial Inflammation Detected With <sup>18</sup> F‐Fluorodeoxyglucose–Positron Emission Tomography in Rheumatoid Arthritis
Authors: Laura Geraldino‐Pardilla, Afshin Zartoshti, Ayse Bag Ozbek, Jon T. Giles, Richard Weinberg, Mona Kinkhabwala, Sabahat Bokhari, Joan M. Bathon
Journal: Arthritis & Rheumatology (2017)

Objective In addition to traditional risk factors, excess cardiovascular disease ( CVD ) in rheumatoid arthritis ( RA ) is attributed to enhanced vascular and/or systemic inflammation. In several small studies using 18 F‐fluorodeoxyglucose–positron emission tomography/computed tomography ( 18 F‐ FDG – PET / CT ) to directly assess vascular inflammation, FDG uptake was higher in RA patients than in controls. Using a substantially larger sample of RA patients, we sought to identify RA disease characteristics independently associated with vascular FDG uptake. Methods RA patients underwent cardiac FDG ‐ PET / CT , with aortic inflammation assessed by quantification of FDG uptake in the ascending aorta, calculated as the mean and maximum (max) standardized uptake value ( SUV ) of the entire ascending aorta and of its most diseased segment ( SUV MDS ). Univariate and multivariable regression models were constructed to model the associations of patient characteristics with aortic FDG uptake. Results Ninety‐one RA patients were scanned. In multivariable models, in addition to the independent associations of hypertension and body mass index with increased aortic FDG uptake, the prevalence of rheumatoid nodules correlated with the SUV mean and SUV MDS mean measures, while anti–cyclic citrullinated peptide (anti‐ CCP ) antibodies correlated inversely with these measures and with the SUV max and SUV MDS max ( P &lt; 0.05). A significant association of RA disease activity with aortic FDG uptake was observed but was restricted to anti‐ CCP seropositivity. Conclusion Traditional CV risk factors and RA disease characteristics (rheumatoid nodules and the Disease Activity Score in 28 joints using the C‐reactive protein level in anti‐ CCP antibody–positive individuals) were independently associated with ascending aortic FDG uptake in RA patients without clinical CVD .
Comparison of cytotoxic backbones for first line trastuzumab-containing regimens in HER2-positive advanced esophagogastric cancer: A meta-analysis
Authors: E. ter Veer, A. Creemers, L. de Waal, M.G.H. van Oijen, H.W.M. van Laarhoven
Journal: Annals of Oncology (2017)
Salmonella enterica serotipo Dublin en Austria
Authors: F Allerberger, A Liesegang, K Grif, R Prager, J Danzl, F Höck, J Ottl, M P Dierich, C Berghold, I Neckstaller, H Tschäpe, I. S.T. Fisher
Journal: Eurosurveillance (2002)

En Austria, el serotipo Dublin de Salmonella enterica, adaptado del ganado bovino, rara vez causa infecciones en el hombre. En 2000, Austria se mantuvo dentro de la media europea con una incidencia de 0,1 por millon de habitantes. Nuestros datos indican que la gran mayoria de las infecciones debidas al serotipo Dublin (en el hombre y en animales) estan vinculadas epidemiologicamente a dos distritos del Tirol. Esta concentracion de casos se debe al tipo de cria de ganado tradicional de esta region en la pradera alpina. El riesgo de infeccion cruzada aumenta debido al mantenimiento comunal de animales procedentes de varias granjas. El ganado infectado es una fuente de infeccion para el hombre y la transmision se suele producir al consumir carne vacuna y leche de vaca. La electroforesis en gel de campo pulsado y la ribotipificacion automatizada permitieron encontrar clones caracteristicos de Dublin del Tirol en tres de los cinco aislamientos de infecciones humanas. El despistaje de portadores fecales antes de la trashumancia de los rebanos a riesgo a la pradera alpina y antes de su retorno a las granjas, podria ser un buen punto de partida para impedir la contaminacion cruzada de grandes rebanos y la contaminacion de la pradera por ganado infectado de forma latente. Es necesaria una investigacion adecuada.
Role of Deficient DNA Mismatch Repair Status in Patients With Stage III Colon Cancer Treated With FOLFOX Adjuvant Chemotherapy
Authors: Aziz Zaanan, Qian Shi, Julien Taieb, Steven R. Alberts, Jeffrey P. Meyers, Thomas C. Smyrk, Catherine Julie, Ayman Zawadi, Josep Tabernero, Enrico Mini, Richard M. Goldberg, Gunnar Folprecht, Jean Luc Van Laethem, Karine Le Malicot, Daniel J. Sargent, Pierre Laurent-Puig, Frank A. Sinicrope
Journal: JAMA Oncology (2017)

The prognostic impact of DNA mismatch repair (MMR) status in stage III colon cancer patients receiving FOLFOX (folinic acid, fluorouracil, and oxaliplatin) adjuvant chemotherapy remains controversial.
Abstract 12046: ARFI Ultrasound Elastography Measures Isovolumic Relaxation Time Constant for Assessment of Diastolic Function
Authors: Maryam Vejdani-Jahromi, Jenna Freedman, Young Joong-Kim, Jenna Osborn, Gregg Trahey, Patrick Wolf
Journal: Circulation (2016)

Introduction: Diastolic dysfunction is a leading cause of morbidity and mortality in heart failure. Assessment of diastolic function has been a challenging topic for many decades. One index of diastolic function is the isovolumic relaxation time constant (τ). This measurement is not used routinely in the clinic because it requires a left ventricular (LV) pressure catheter. Other noninvasive methods provide correlates of the time constant but do not measure the actual value. It has been shown recently that ultrasound elastography (Acoustic Radiation Force Impulse Imaging (ARFI)) can provide a temporal stiffness measurement of the myocardium during the cardiac cycle. The clinical value of the ARFI measured time course of softening has not been shown. Hypothesis: We assessed the hypothesis that ARFI Elastography can be used to measure the isovolumic relaxation time constant of the LV. Methods: This study was performed in eight isolated rabbit hearts in working mode. A pressure catheter was used to record the LV pressure simultaneously with ARFI. LV free wall ARFI measurements were recorded using an ultrasound probe. In order to extend the range of τ (tau) measurements, 3 of the subjects were subjected to ischemia (total of 11 measurements from 8 subjects). Results: Tau measured by ARFI was linearly related to the τ measurement derived from LV pressure with the slope of 0.92 and R 2 = 0.90 indicating the near equivalence of the values. Mean ± SEM of τ derived from pressure and ARFI were 33.7 ± 6.4 ms and 34.8 ± 6.2 ms respectively. Conclusions: ARFI ultrasound elastography can be used to measure the relaxation time constant of the left ventricle. This is the first time that τ has been measured directly using an ultrasound technique. ARFI measurements have the benefits of ultrasound imaging including noninvasiveness, cost efficiency and portability. Translation of this technique to transthoracic imaging in humans would provide an important screening measure of diastolic function.
Les SARM dans les hôpitaux de long et moyen séjour aux Pays-Bas de 1989 à 1998 : un réservoir en expansion ?
Authors: W Goettsch, E Geubbels, W J B Wannet, M G R Hendrix, J H T Wagenvoort, A J de Neeling
Journal: Eurosurveillance (2000)

En 1998, la prevalence des Staphylococcus aureus resistants a la meticilline (SARM) isoles dans les hopitaux de long et moyen sejour neerlandais etait superieure a celle observee de 1989 a 1997. Cette prevalence accrue des SARM pourrait mener a une diffusion en dehors de ces hopitaux. Une etude sur la prevalence des MRSA dans les hopitaux de long et moyen sejour, qui devrait debuter a la mi-2000, etudiera leur role comme reservoirs des infections nosocomiales a MRSA.
Robot-assisted vs laparoscopic vs open abdominoperineal resections for low rectal cancer: Short-term outcomes of a single-center prospective randomized controlled trial
Authors: J. Xu, Y. Wei, L. Ren, Q. Feng, J. Chen, D. Zhu, W. Chang, T. Yi, L. Yang, X. Qin
Journal: Annals of Oncology (2017)
Lymphoplasmacytoid cytology in plasma cell leukemia
Authors: Ahmad Khoder, Magda Al Obaidi, Natasha Wiles, Elisabet Nadal‐Melsio, Barbara J. Bain
Journal: American Journal of Hematology (2017)

Initially septic shock with multi-organ failure and coagulopathy was suspected. However his blood film showed that almost all the lymphocytes were abnormal with some having plasmacytoid features including cytoplasmic basophilia, eccentric nuclei, a Golgi zone, and a clock-face chromatin pattern (images). A diagnosis of plasma cell leukemia was confirmed by flow cytometric immunophenotyping, which identified a dominant population of CD45 dim/negative, small to medium sized cells. There was weak CD138 expression and downregulated CD38; cells expressed cytoplasmic lambda light chain and showed partial coexpression of CD19 (26%), CD20 (74%) and CD56 (25%). Normal polytypic B cells were extremely scanty. The bone marrow was hypercellular with 78% lymphoplasmacytoid cells with a similar but not identical immunophenotype. There was an immunoglobulin (Ig) G lambda paraprotein with reduction of normal immunoglobulins: IgA 0.14 g/L (0.81-4.63), IgG 98.1 (6.94-16.18), and IgM <0.20 (0.48-2.71). Plasma viscosity was increased to 3.80 mPA (1.50-1.72). The patient required haemofiltration and inotropic and respiratory support and was commenced on reduced dose bortezomib. He made a remarkable recovery and was discharged from the intensive care ward after 7 days, continuing to show steady improvement thereafter. The cytological features of plasma cell leukemia are very variable from case to case, covering the full spectrum seen in multiple myeloma. However often, as in our patient, the neoplastic cells are relatively small with lymphoplasmacytoid features. Differing from most types of myeloma, CD56 may not be expressed (partial expression was seen in our patient).
A Phase II study of sorafenib and yttrium-90 glass microspheres for advanced hepatocellular carcinoma, BCLC stage C
Authors: A.O. Kaseb, R. Abdel-Wahab, R. Murthy, M. Hassan, K. Raghav, L. Xiao, J. Morris, R. Avritscher, B.C. Odisio, C. Ohaji, R.A. Wolff, J.C. Yao, A. Mahvash
Journal: Annals of Oncology (2017)