tbuckley/cabot-search huggingface dataset:
TCT-437 A novel preoperative assessment of coronary obstruction following TAVR procedure -Development view of the aortic root
Authors: Koichi Maeda, Toru Kuratani, Kei Torikai, Isamu Mizote, Toshinari Onishi, Takashi Mukai, Masaki Tsuda, Takayoshi Ueno, Koichi Toda, Yasushi Sakata, Yoshiki Sawa
Journal: Journal of the American College of Cardiology (2017)
Human Periodontal Ligament‐ and Gingiva‐derived Mesenchymal Stem Cells Promote Nerve Regeneration When Encapsulated in Alginate/Hyaluronic Acid 3D Scaffold
Authors: Sahar Ansari, Ivana M. Diniz, Chider Chen, Patricia Sarrion, Ali Tamayol, Benjamin M. Wu, Alireza Moshaverinia
Journal: Advanced Healthcare Materials (2017)

Abstract Repair or regeneration of damaged nerves is still a challenging clinical task in reconstructive surgeries and regenerative medicine. Here, it is demonstrated that periodontal ligament stem cells (PDLSCs) and gingival mesenchymal stem cells (GMSCs) isolated from adult human periodontal and gingival tissues assume neuronal phenotype in vitro and in vivo via a subcutaneous transplantation model in nude mice. PDLSCs and GMSCs are encapsulated in a 3D scaffold based on alginate and hyaluronic acid hydrogels capable of sustained release of human nerve growth factor (NGF). The elasticity of the hydrogels affects the proliferation and differentiation of encapsulated MSCs within scaffolds. Moreover, it is observed that PDLSCs and GMSCs are stained positive for βIII‐tubulin, while exhibiting high levels of gene expression related to neurogenic differentiation (βIII‐tubulin and glial fibrillary acidic protein) via quantitative polymerase chain reaction (qPCR). Western blot analysis shows the importance of elasticity of the matrix and the presence of NGF in the neurogenic differentiation of encapsulated MSCs. In vivo, immunofluorescence staining for neurogenic specific protein markers confirms islands of dense positively stained structures inside transplanted hydrogels. As far as it is known, this study is the first demonstration of the application of PDLSCs and GMSCs as promising cell therapy candidates for nerve regeneration.
The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma
Authors: Alex KleinJan, Irma Tindemans, Jeffrey E. Montgomery, Melanie Lukkes, Marjolein J.W. de Bruijn, Menno van Nimwegen, Ingrid Bergen, Raymond E. Moellering, Henk C. Hoogsteden, Louis Boon, Derk Amsen, R.W. Hendriks
Journal: Journal of Allergy and Clinical Immunology (2017)
Connecting Biology to Electronics: Molecular Communication via Redox Modality
Authors: Yi Liu, Jinyang Li, Tanya Tschirhart, Jessica L. Terrell, Eunkyoung Kim, Chen‐Yu Tsao, Deanna L. Kelly, William E. Bentley, Gregory F. Payne
Journal: Advanced Healthcare Materials (2017)

Abstract Biology and electronics are both expert at for accessing, analyzing, and responding to information. Biology uses ions, small molecules, and macromolecules to receive, analyze, store, and transmit information, whereas electronic devices receive input in the form of electromagnetic radiation, process the information using electrons, and then transmit output as electromagnetic waves. Generating the capabilities to connect biology–electronic modalities offers exciting opportunities to shape the future of biosensors, point‐of‐care medicine, and wearable/implantable devices. Redox reactions offer unique opportunities for bio‐device communication that spans the molecular modalities of biology and electrical modality of devices. Here, an approach to search for redox information through an interactive electrochemical probing that is analogous to sonar is adopted. The capabilities of this approach to access global chemical information as well as information of specific redox‐active chemical entities are illustrated using recent examples. An example of the use of synthetic biology to recognize external molecular information, process this information through intracellular signal transduction pathways, and generate output responses that can be detected by electrical modalities is also provided. Finally, exciting results in the use of redox reactions to actuate biology are provided to illustrate that synthetic biology offers the potential to guide biological response through electrical cues.
BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis
Authors: Peter R. Bucciarelli, Kay See Tan, Neel P. Chudgar, Whitney Brandt, Joseph Montecalvo, Takashi Eguchi, Yuan Liu, Rania Aly, William D. Travis, Prasad S. Adusumilli, David R. Jones
Journal: Journal of Thoracic Oncology (2017)
An Annular Eruption on the Trunk and Limbs
Authors: Clara Fernández-Sartorio, Llúcia Alós, José M. Mascaró
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
TCT-104 Initial Pre-clinical and Clinical Use of Mechanical Intracardiac Echocardiography System with 3D Viewing, Color Doppler and Side-viewing Capabilities
Authors: Brian Courtney, Atul Verma, Amandeep Thind, Alan Soong, Marc Lukacs, M. Saleem, Natasha Alves-Kotzev, Bogdan Neagu
Journal: Journal of the American College of Cardiology (2017)
Early detection of competing resistance mutations using plasma next-generation sequencing (NGS) in patients (pts) with <i>EGFR</i>-mutant NSCLC treated with osimertinib.
Authors: Nicolas Marie Guibert, Cloud Paweletz, Yuebi Hu, Nora B. Feeney, Vincent Plagnol, Valerie Poole, Greg Jones, Geoffrey R. Oxnard
Journal: Journal of Clinical Oncology (2017)

11529 Background: In pts with EGFR+ NSCLC, genotyping of plasma cell-free DNA (cfDNA) has become a routine option for non-invasive detection of EGFRT790M. We hypothesized that serial NGS of cfDNA would allow early detection of co-existent resistance mutations during osimertinib treatment. Methods: Serial plasma samples were collected from pts with advanced EGFR+ NSCLC and T790M+ acquired resistance treated with osimertinib. Up to 4 specimens were analyzed, blinded to tumor genotype: baseline, initial 2 follow-ups, and progression. Plasma NGS was performed using enhanced tagged amplicon sequencing of hotspots and coding regions from 36 genes. Diagnostic accuracy was compared to tumor genotype (including NGS when available) and droplet digital PCR (ddPCR) of cfDNA. Results: 94 specimens from 26 pts underwent plasma NGS. Studying 26 baseline specimens, plasma NGS was more sensitive than ddPCR for known EGFR driver mutations (100% vs 88.5%). In 8 pts with pretreatment tumor NGS, 5 of 6 TP53 mutations were detected; one plasma positive/tissue negative result was seen across 36 genes, a PIK3CA mutation (0.6% AF) which was confirmed using ddPCR (99.6% specificity). Quantitative concordance of AF compared to ddPCR was high (R = 0.94). 21 pts had detectable EGFR driver mutations at resistance. Among 6 pts with maintained T790M, 4 acquired C797S and 2 of these additionally acquired low level KRAS mutations (G13D, Q61K). Among 15 pts with loss of T790M, 7 had competing non- EGFR alterations identified: MET amp, PIK3CA E545K, BRAF V600E (n = 2), HER2 amp, KRAS G12S, and FGFR1 amp. Resistance mutations detected at AF &gt; 0.3% were confirmed with ddPCR. In 3 pts, a competing resistance mutation (1 KRAS, 2 BRAF) could be detected in plasma NGS pretreatment and reemerged as putative drivers at time of resistance. Conclusions: In this retrospective blinded validation, tagged amplicon-based plasma NGS was more sensitive than ddPCR with high specificity and quantitative concordance. In a subset of cases, serial plasma NGS can detect emergence of competing resistance mutations, creating an opportunity for the study of osimertinib-based targeted therapy combinations.
Variant Review with the Integrative Genomics Viewer
Authors: James T. Robinson, Helga Thorvaldsdóttir, Aaron M. Wenger, Ahmet Zehir, Jill P. Mesirov
Journal: Cancer Research (2017)

Abstract Manual review of aligned reads for confirmation and interpretation of variant calls is an important step in many variant calling pipelines for next-generation sequencing (NGS) data. Visual inspection can greatly increase the confidence in calls, reduce the risk of false positives, and help characterize complex events. The Integrative Genomics Viewer (IGV) was one of the first tools to provide NGS data visualization, and it currently provides a rich set of tools for inspection, validation, and interpretation of NGS datasets, as well as other types of genomic data. Here, we present a short overview of IGV's variant review features for both single-nucleotide variants and structural variants, with examples from both cancer and germline datasets. IGV is freely available at https://www.igv.org. Cancer Res; 77(21); e31–34. ©2017 AACR.
Experiencias con la nueva variante genética de Chlamydia trachomatis en el condado de Örebro, Suecia: proporción, características y solución diagnóstica eficaz en una situación emergente
Authors: M Unemo, P Olcén, I Agné-Stadling, A Feldt, M Jurstrand, B Herrmann, K Persson, P Nilsson, T Ripa, H Fredlund
Journal: Eurosurveillance (2007)

Recientemente se ha notificado en Suecia una variante de Chlamydia trachomatis que contiene una delecion de 377 pares de bases en el plasmido criptico. Esta delecion abarca los ‘targets’ para Cobas Amplicor, Cobas TaqMan48 y Abbott m2000. Hemos examinado la proporcion y las caracteristicas de esta variante en el condado de Orebro, Suecia y hemos desarrollado una solucion diagnostica eficaz.
Nanoparticle‐Based Therapeutics for Brain Injury
Authors: Vimala N. Bharadwaj, Duong T. Nguyen, Vikram D. Kodibagkar, Sarah E. Stabenfeldt
Journal: Advanced Healthcare Materials (2017)

Brain injuries affect a large patient population with major physical and emotional suffering for patients and their relatives; at a significant cost to the society. Effective diagnostic and therapeutic options available for brain injuries are limited by the complex brain injury pathology involving blood-brain barrier (BBB). Brain injuries, including ischemic stroke and brain trauma, initiate BBB opening for a short period of time, which is followed by a second reopening for an extended time. The leaky BBB and/or the alterations in the receptor expression on BBB may provide opportunities for therapeutic delivery via nanoparticles (NPs). The approaches for therapeutic interventions via NP delivery are aimed at salvaging the pericontusional/penumbra area for possible neuroprotection and neurovascular unit preservation. The focus of this progress report is to provide a survey of NP strategies employed in cerebral ischemia and brain trauma and finally provide insights for improved NP-based diagnostic/treatment approaches.
Long-term follow-up of the incidence of Helicobacter pylori
Authors: M. Rowland, M. Clyne, L. Daly, H. O'Connor, B. Bourke, G. Bury, T. O'Dowd, L. Connolly, J. Ryan, S. Shovlin, B. Dolan, B. Drumm
Journal: Clinical Microbiology and Infection (2017)
Canadian researchers whose studies questioned vaccine safety face second retraction
Authors: Owen Dyer
Journal: BMJ (2017)

A study that linked aluminium vaccine adjuvants to genetic changes “homologous with biomarkers of autism” in mice is to be retracted by the Journal of Inorganic Chemistry .1

The retraction comes after readers of the website PubPeer claimed to have found image alterations in the paper. The study authors Christopher Shaw and Lucija Tomljenovic of the University of British Columbia then reviewed the data and found evidence of western blot image alterations. They contacted the journal and asked for the retraction, Shaw told The BMJ .

The journal’s editor, John Dawson of the University of South Carolina, told the website Retraction Watch, “The paper by Shaw and co-workers is being retracted jointly by the authors …
Legioneloses associadas a viagens de turistas europeus a Espanha - o comentário do Centro Coordenador EWGLI
Authors: C Joseph
Journal: Eurosurveillance (1997)

Este interessante artigo analisa os dados de casos de legionelose associados a viagens a Espanha, permitindo destacar aspectos relevantes do Grupo Europeu para a Vigilância das Infeccoes a Legionela (EWGLI), isto e, a notificacao de casos com informacao incompleta, observadas particularmente nos primeiros anos do sistema que tornam dificil a interpretacao dos dados. 
O software EWGLI esta actualmente a ser rescrito, tendo em atencao desenvolvimentos futuros no sistema, de modo a incluir metodos mais desenvolvidos de analise. O novo software sera distribuido pelos varios centros ate ao final do corrente ano.
TCT-14 Safety and Clinical Performance of the Drug Eluting Absorbable Metal Scaffold in the Treatment of Subjects with de Novo Lesions in Native Coronary Arteries at 12-month follow-up- BIOSOLVE-II and BIOSOLVE-III
Authors: Michael Haude, Hüseyin Ince, Stephan Kische, Alexandre Abizaid, Ralph Toelg, Pedro A. Lemos, Nicolas Van Mieghem, Stefan Verheye, Clemens von Birgelen, Evald Christiansen, Marco Valgimigli, William Wijns, Franz-Josef Neumann, Bernhard Witzenbichler, Javier Escaned, Hector Garcia-Garcia, Ron Waksman
Journal: Journal of the American College of Cardiology (2017)
CAR-T Cells: A Systematic Review and Mixed Methods Analysis of the Clinical Trial Landscape
Authors: David Pettitt, Zeeshaan Arshad, James Smith, Tijana Stanic, Georg Holländer, David Brindley
Journal: Molecular Therapy (2017)

CAR-T cells are a promising new therapy that offer significant advantages compared with conventional immunotherapies. This systematic review and clinical trial landscape identifies and critiques published CAR-T cell clinical trials and examines the critical factors required to enable CAR-T cells to become a standard therapy. A review of the literature was conducted to identify suitable studies from the MEDLINE and Ovid bibliographic databases. The literature and database searches identified 20 studies for inclusion. The average number of participants per clinical trial examined was 11 patients. All studies included in this systematic review investigated CAR-T cells and were prospective, uncontrolled clinical studies. Leukemia is the most common cancer subtype and accounts for 57.4% (n = 120) of disease indications. The majority of studies used an autologous cell source (85%, n = 17) rather than an allogeneic cell source. Translational challenges encompass technical considerations relating to CAR-T cell development, manufacturing practicability, clinical trial approaches, CAR-T cell quality and persistence, and patient management.
Abstract 19337: Preliminary Evaluation of a Pressor-Enhanced Approach to Robotic Signal-Guided Cardiopulmonary Resuscitation in a Swine Model of Ventricular Fibrillation
Authors: David D Salcido, Matthew L Sundermann, Allison C Koller, Katharyn L Flickinger, James J Menegazzi
Journal: Circulation (2016)

Introduction:  Cardiopulmonary resuscitation (CPR) is largely a fixed process that does not adapt to the patient. Signal-guided (SG) CPR uses real-time signal analysis to optimize CPR and improve outcomes. The effects of pressors on SG-CPR are not fully known.   Hypothesis:  We hypothesized that SG-CPR with SG-pressor administration would be feasible and would outperform standard CPR in a swine model of ventricular fibrillation (VF).   Methods:  Mixed-breed (n = 19) swine were sedated, anesthetized, paralyzed, intubated and ventilated. Aortic and right atrial pressures were measured invasively. Coronary perfusion pressure was taken as the difference. Electrocardiogram (ECG) leads were placed for Leads I, II, and III, and the VF ECG median slope (MS) was calculated. VF was induced with a 3-second transthoracic shock and untreated for 8 minutes. Animals were randomized to SG-CPR or standard mechanical CPR (Std-CPR) with a custom SG-CPR device. Starting compression rate and depth were 100/minute and 2 inches, in 30:2 CPR configuration. In the SG-CPR group, the device incremented rate by 5 compressions/minute and depth by 0.2 inches per minute until a CPP threshold of 35mmHg or MS exceeded 75% its value at start of VF. In the Std-CPR group, epinephrine (0.015mg/kg) was administered at 2 minutes and repeated q3 minutes; in the SG-CPR group it was administered every 30 seconds until CPP exceeded 35mmHg. Defibrillation was attempted after 5 minutes of CPR, and CPR continued until return of spontaneous circulation (ROSC) or 20 minutes. Outcomes were time-to-peak CPP and MS, threshold passed, and ROSC. Continuous measures were compared with t-tests, dichotomous outcomes with Chi Squared tests.   Results:  Mean (SD) time to peak CPP was 162s (87) Std-CPR and 57s (109) for SG-CPR (p=0.35). Time to peak MS was 194s (46) Std-CPR and 65s (114) for SG-CPR (p=0.88). Threshold achievement for CPP (p = 0.22) and MS (p = 0.22) was 50% and 38% for SG-CPR and 22% and 67% for Std-CPR. ROSC was 75% for SG-CPR and 44% for Std-CPR (p = 0.20).   Conclusions:  SG-CPR with SG-epinephrine was feasible but did not outperform Std-CPR in hemodynamic, ECG or ROSC outcomes.
TCT-511 Does Pulmonary Artery Catheterization improve in-hospital outcomes in patients with cardiogenic shock: ANALYSIS FROM NATIONAL INPATIENT SAMPLE (NIS)
Authors: Gursukhmandeep Sidhu, Samir Pancholy, Anurag Bajaj, Qasim Malik, Sukrut Nanavaty, Arpit Sothwal, Gaurav Patel
Journal: Journal of the American College of Cardiology (2017)
On the substantial contribution of “contempt” as a folk affect concept to the history of the European popular institution of <i>charivari</i>
Authors: Bogdan Neagota, Ileana Benga, Oana Benga
Journal: Behavioral and Brain Sciences (2017)

Abstract The integration of the folk affect concept of “contempt” into the analysis of the complex institution known generally as charivari is mutually beneficial for both ethno-anthropology (which may thus access inner causes for disputed social and collective behaviors) and evolutionary psychology (which may thus study the length of tradition together with the width of the institution spread, serving the same social functions).
TCT-422 Pre-procedural white matter lesion burden predicts MRI outcomes in transcatheter aortic valve replacement (TAVR): The Sentinel Trial
Authors: Michael Dwyer, Axel Linke, Carlye Kraemer, Roseann White, Ronald Lazar, Samir Kapadia, Susheel Kodali, Thomas Engels, Azin Parhizgar, Roxana Mehran, Raj Makkar, Saif Anwaruddin, Martin Leon, Robert Zivadinov
Journal: Journal of the American College of Cardiology (2017)
TCT-795 Human cell derived off-the-shelf Tissue Engineered Heart Valves for next generation Transcatheter Aortic Valve Replacement: a proof-of-concept study in adult sheep
Authors: Valentina Lintas, Emanuela Fioretta, Petra Dijkman, Etem Caliskan, Hector Rodriguez, Nikola Cesarovic, Simon Hoerstrup, Maximilian Emmert
Journal: Journal of the American College of Cardiology (2017)
TCT-764 Usefulness of the Novel Ultrasonography Guided Central Wiring Technique in Endovascular Therapy for Chronic Total Occlusion of Femoro-popliteal Arteries
Authors: Hideyuki Takimura, Toshiya Muramatsu, Reiko Tsukahara, Masatsugu Nakano, Satoshi Nishio, Yukako Takimura, Takayuki Yabe, Mami Kawano, Tasuku Hata
Journal: Journal of the American College of Cardiology (2017)
Recombination Alters the Dynamics of Adaptation on Standing Variation in Laboratory Yeast Populations
Authors: Katya Kosheleva, Michael M Desai
Journal: Molecular Biology and Evolution (2017)

The rates and selective effects of beneficial mutations, together with population genetic factors such as population size and recombination rate, determine the outcomes of adaptation and the signatures this process leaves in patterns of genetic diversity. Previous experimental studies of microbial evolution have focused primarily on initially clonal populations, finding that adaptation is characterized by new strongly selected beneficial mutations that sweep rapidly to fixation. Here, we study evolution in diverse outcrossed yeast populations, tracking the rate and genetic basis of adaptation over time. We combine time-serial measurements of fitness and allele frequency changes in 18 populations of budding yeast evolved at different outcrossing rates to infer the drivers of adaptation on standing genetic variation. In contrast to initially clonal populations, we find that adaptation is driven by a large number of weakly selected, linked variants. Populations undergoing different rates of outcrossing make use of this selected variation differently: whereas asexual populations evolve via rapid, inefficient, and highly variable fixation of clones, sexual populations adapt continuously by gradually breaking down linkage disequilibrium between selected variants. Our results demonstrate how recombination can sustain adaptation over long timescales by inducing a transition from selection on genotypes to selection on individual alleles, and show how pervasive linked selection can affect evolutionary dynamics.
Epidemic intelligence : un nouveau cadre pour renforcer la surveillance des maladies en Europe
Authors: C Paquet, D Coulombier, R Kaiser, M Ciotti
Journal: Eurosurveillance (2006)

Dans un environnement en rapide evolution, il devient difficile pour les institutions nationales chargees de la securite sanitaire de se fier exclusivement aux systemes traditionels de surveillance des maladies qui n’ont pas ete concus pour identifier l’emergence de risques nouveaux. L’epidemic intelligence (EI) fournit un cadre conceptuel qui permettra aux pays d’adapter leurs systemes de surveillance national pour repondre a ce nouveau defi. 
L’EI inclut toutes les activites liees a l’identification precoce des risques potentiels pour la sante, leur verification et leur evaluation, et l’investigation permettant de faire des recommandations de mesures de controle en sante publique. EI integre deux types de composante, l’une basee sur des evenements et l’autre sur des indicateurs. Cette derniere composante correspond aux donnees structurees recueillies via les systemes de surveillance en routine. Quant a la composante ‘evenementielle’ elle se rapporte aux donnees non structurees captees a partir de sources d’informations de toute nature. 
Tous les Etats membres de l’UE disposent de longue date de systemes de surveillance fournissant une surveillance adaptee basee sur des indicateurs. La plupart des pays vont desormais devoir developper et structurer la composante evenementielle de l’EI au sein des institutions nationales chargees de la surveillance en sante publique. 
En mai 2006, les Etats membres de l’Union europeenne se sont engages a se conformer aux dispositions du reglement sanitaire international revise (RSI(2005)) jugees necessaires face aux risques potentiels de pandemie de grippe aviaire et humaine. Hormis le role du Centre europeen de Prevention et de controle des Maladies (European Centre for Disease Prevention and Control, ECDC) dans le developpement d’un systeme d’EI europeen pour l’Union europeenne, cet engagement des Etats a donne a l’ECDC l’occasion de guider des Etats membres dans le developpement et/ou le renforcement de leur capacite d’EI nationale.