Increasing Incidence of Multiply Recurrent <i>Clostridium difficile</i> Infection
Authors: Jodie A. Barkin, Neil Stollman, Jamie S. Barkin
Journal: Annals of Internal Medicine (2018)

Letters20 February 2018Increasing Incidence of Multiply Recurrent Clostridium difficile InfectionJodie A. Barkin, MD, Neil Stollman, MD, and Jamie S. Barkin, MDJodie A. Barkin, MDUniversity of Miami, Leonard M. Miller School of Medicine, Miami, Florida (J.A.B., J.S.B.)Search for more papers by this author, Neil Stollman, MDAlta Bates Summit Medical Center, Oakland, California (N.S.)Search for more papers by this author, and Jamie S. Barkin, MDUniversity of Miami, Leonard M. Miller School of Medicine, Miami, Florida (J.A.B., J.S.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0601 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read Ma and colleagues' (1) article on the increasing incidence of mrCDI in the United States and Saini and Waljee's accompanying editorial (2) with great interest. Ma and colleagues showed an impressive trend of a 42.7% increase in CDI and a 188.8% increase in persons with multiple recurrent episodes of CDI between 2001 and 2012. We currently treat CDI unlike other infections because we do not routinely determine its sensitivity to antibiotic therapy. We agree with Saini and Waljee that this fact “begs for a better understanding” to guide CDI treatment.Treatment is currently determined by ...References1. Ma GK, Brensinger CM, Wu Q, Lewis JD. Increasing incidence of multiply recurrent Clostridium difficile infection in the United States: a cohort study. Ann Intern Med. 2017;167:152-8. [PMID: 28672282]. doi:10.7326/M16-2733 LinkGoogle Scholar2. Saini SD, Waljee AK. Fool me thrice: the evolving story of multiply recurrent Clostridium difficile infection. Ann Intern Med. 2017;167:202-3. [PMID: 28672286]. doi:10.7326/M17-1565 LinkGoogle Scholar3. Surawicz CM, Brandt LJ, Binion DG, Ananthakrishnan AN, Curry SR, Gilligan PH, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol. 2013;108:478-98. [PMID: 23439232] doi:10.1038/ajg.2013.4 CrossrefMedlineGoogle Scholar4. Barkin JA, Sussman DA, Fifadara N, Barkin JS. Clostridium difficile infection and patient-specific antimicrobial resistance testing reveals a high metronidazole resistance rate. Dig Dis Sci. 2017;62:1035-42. [PMID: 28116592] doi:10.1007/s10620-017-4462-9 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Miami, Leonard M. Miller School of Medicine, Miami, Florida (J.A.B., J.S.B.)Alta Bates Summit Medical Center, Oakland, California (N.S.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0601. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIncreasing Incidence of Multiply Recurrent Clostridium difficile Infection in the United States Gene K. Ma , Colleen M. Brensinger , Qufei Wu , and James D. Lewis Increasing Incidence of Multiply Recurrent Clostridium difficile Infection Gene K. Ma and James D. Lewis Increasing Incidence of Multiply Recurrent Clostridium difficile Infection Mark Wilcox Metrics 20 February 2018Volume 168, Issue 4Page: 307-308KeywordsAntibiotic resistanceAntibioticsAntimicrobial resistanceAntimicrobialsClostridium infectionsDisclosureImidazolePathogenesisPatientsVancomycin ePublished: 20 February 2018 Issue Published: 20 February 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...