tbuckley/cabot-search huggingface dataset:
Knocking out consumer concerns and regulator’s rules: efficient use of CRISPR/Cas ribonucleoprotein complexes for genome editing in cereals
Authors: Felix Wolter, Holger Puchta
Journal: Genome biology (2017)

Selection-free genome editing using Cas9 ribonucleoprotein embryo bombardment has been achieved for maize and wheat. This is a breakthrough that should make new breeding technologies more acceptable for worldwide use.
Response to Letter to the Editor by M. van der Werf, V. Hollo and C. Ködmön concerning ‘Multidrug-resistant tuberculosis and migration to Europe’
Authors: S. Hargreaves, K. Lönnroth, L.B. Nellums, I.D. Olaru, R.R. Nathavitharana, M. Norredam, J.S. Friedland
Journal: Clinical Microbiology and Infection (2017)
Gum disease is an early sign of diabetes, and tooth loss is associated with risk of dementia, studies find
Authors: Susan Mayor
Journal: BMJ (2017)

Patients with periodontitis have higher plasma concentrations of glycated haemoglobin (HbA1c) than people with healthy gums, and those with severe periodontitis have a significantly higher risk of developing diabetes, a Dutch study has found.

Previous studies had indicated an association between oral disease and diabetes, so researchers investigated whether periodontitis could provide a useful warning sign of type 2 diabetes. They studied 313 consecutive patients visiting a university dental clinic …
Identification of Novel, Non-Synonymous Sequence Changes in the Tyrosine Kinase Genes of Patients with Acute Myeloid Leukemia.
Authors: Zhifu Xiang, Yu Zhao, Vesselin Mitaksov, Daved H. Fremont, Yumi Kasai, AnnaLynn Molitoris, Rhonda E. Ries, Tracie Miner, Michael D. McLellan, John F. DiPersio, Daniel C. Link, Jacqueline E. Payton, Timothy A. Graubert, Mark Watson, William Shannon, Sharon Heath, Elaine R. Mardis, Richard K. Wilson, Timothy J. Ley, Michael H. Tomasson
Journal: Blood (2007)
Vitamine B12 Deficiency Presenting As Severe Pancytopenia in Adult Patients. a Monocentric Study of 104 Cases
Authors: Zoubida Tazi Mezalek, Wafaa Ammouri, Mouna Maamar, Meriem Bourkia, Hicham Harmouche, Mohammed Adnaoui, Meryem Alaoui, Nisrine Bouigua
Journal: Blood (2016)
Exploring the Possibility of Using Herpes Simplex Virus in Oncolytic Virotherapy of Multiple Myeloma
Authors: Jayeeta Ghose, Luke Russell, Enrico Caserta, Ramasamy Santhanam, Alena Cristina Jaime-Ramirez, Domenico Viola, Amrita Krishnan, Craig C Hofmeister, Balveen Kaur, Flavia Pichiorri
Journal: Blood (2016)
A Novel Pan-PIM Kinase Inhibitor, SEL24-B489, Induces Apoptosis and Inhibits Proliferation of Diffuse Large B-Cell Lymphoma Cells through Inhibition of Protein Translation and Attenuation of Myc and NFkB Activity
Authors: Ewa Jablonska, Maciej Szydlowski, Emilia Bialopiotrowicz, Przemyslaw Kiliszek, Tomasz Sewastianik, Anna Polak, Krzysztof Warzocha, Wojciech Czardybon, Michal Galezowski, Renata Windak, Aniela Golas, Krzysztof Brzozka, Przemyslaw Juszczynski
Journal: Blood (2015)
Efficacy of Internet-Based Cognitive Behavioral Therapy in Improving Sexual Functioning of Breast Cancer Survivors: Results of a Randomized Controlled Trial
Authors: Susanna B. Hummel, Jacques J.D.M. van Lankveld, Hester S.A. Oldenburg, Daniela E.E. Hahn, Jacobien M. Kieffer, Miranda A. Gerritsma, Marianne A. Kuenen, Nina Bijker, Paul J. Borgstein, Gijsbert Heuff, Alexander M.F. Lopes Cardozo, Peter W. Plaisier, Herman Rijna, Suzan van der Meij, Eric J. van Dulken, Bart C. Vrouenraets, Eva Broomans, Neil K. Aaronson
Journal: Journal of Clinical Oncology (2017)

Purpose We evaluated the effect of Internet-based cognitive behavioral therapy (CBT) on sexual functioning and relationship intimacy (primary outcomes) and body image, menopausal symptoms, marital functioning, psychological distress, and health-related quality of life (secondary outcomes) in breast cancer survivors (BCSs) with a DSM-IV diagnosis of a sexual dysfunction. Patients and Methods We randomly assigned 169 BCSs to either Internet-based CBT or a waiting-list control group. The CBT consisted of weekly therapist-guided sessions, with a maximum duration of 24 weeks. Self-report questionnaires were completed by the intervention group at baseline (T0), midtherapy (T1), and post-therapy (T2) and at equivalent times by the control group. We used a mixed-effect modeling approach to compare the groups over time. Results Compared with the control group, the intervention group showed a significant improvement over time in overall sexual functioning (effect size for T2 [EST2] = .43; P = .031), which was reflected in an increase in sexual desire (EST1 = .48 and EST2 = .72; P < .001), sexual arousal (EST2 = .50; P = .008), and vaginal lubrication (EST2 = .46; P = .013). The intervention group reported more improvement over time in sexual pleasure (EST1 = .32 and EST2 = .62; P = .001), less discomfort during sex (EST1 = .49 and EST2 = .66; P = .001), and less sexual distress (EST2 = .59; P = .002) compared with the control group. The intervention group reported greater improvement in body image (EST2 = .45; P = .009) and fewer menopausal symptoms (EST1 = .39; P = .007) than the control group. No significant effects were observed for orgasmic function, sexual satisfaction, intercourse frequency, relationship intimacy, marital functioning, psychological distress, or health-related quality of life. Conclusion Internet-based CBT has salutary effects on sexual functioning, body image, and menopausal symptoms in BCSs with a sexual dysfunction.
Rethinking Environmental Protection: Meeting the Challenges of a Changing World
Authors: Thomas A. Burke, Wayne E. Cascio, Daniel L. Costa, Kacee Deener, Thomas D. Fontaine, Florence A. Fulk, Laura E. Jackson, Wayne R. Munns, Jennifer Orme-Zavaleta, Michael W. Slimak, Valerie G. Zartarian
Journal: Environmental Health Perspectives (2017)

From climate change to hydraulic fracturing, and from drinking water safety to wildfires, environmental challenges are changing. The United States has made substantial environmental protection progress based on media-specific and single pollutant risk-based frameworks. However, today’s environmental problems are increasingly complex and new scientific approaches and tools are needed to achieve sustainable solutions to protect the environment and public health. In this article, we present examples of today’s environmental challenges and offer an integrated systems approach to address them. We provide a strategic framework and recommendations for advancing the application of science for protecting the environment and public health. We posit that addressing 21st century challenges requires transdisciplinary and systems approaches, new data sources, and stakeholder partnerships. To address these challenges, we outline a process driven by problem formulation with the following steps: a) formulate the problem holistically, b) gather and synthesize diverse information, c) develop and assess options, and d) implement sustainable solutions. This process will require new skills and education in systems science, with an emphasis on science translation. A systems-based approach can transcend media- and receptor-specific bounds, integrate diverse information, and recognize the inextricable link between ecology and human health.
Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia
Authors: Sarah K. Tasian, Saad S. Kenderian, Feng Shen, Marco Ruella, Olga Shestova, Miroslaw Kozlowski, Yong Li, April Schrank-Hacker, Jennifer J. D. Morrissette, Martin Carroll, Carl H. June, Stephan A. Grupp, Saar Gill
Journal: Blood (2017)
The Survival Outcome of the Patients with Relapsed/Refractory Anaplastic Large-Cell Lymphoma
Authors: Dai Chihara, Michelle A. Fanale, Mansoor Noorani, Jason R Westin, Loretta Nastoupil, Fredrick B. Hagemeister, Luis E. Fayad, Jorge E. Romaguera, Felipe Samaniego, Francesco Turturro, Hun Ju Lee, Sattva S. Neelapu, Alma Rodriguez, Michael Wang, Nathan Fowler, Roberto N. Miranda, Chitra M. Hosing, Yago Nieto, Richard Eric Davis, Yasuhiro Oki
Journal: Blood (2015)
SAMHD1, A Putative Tumour Suppressor, Is Recurrently Mutated in Chronic Lymphocytic Leukaemia, and Is Associated with Poor Risk Features
Authors: Ruth Clifford, Sam Ackroyd, Adam Burns, Adele Timbs, Jonathan Maelfait, Helene Dreau, Shirley Henderson, Mark Ross, David Bentley, Peter Hillmen, Samantha Knight, Jenny Taylor, Chris S.R Hatton, Jan Rehwinkel, Yanick Crow, Anna Schuh
Journal: Blood (2012)
Mindset Matters for Parents and Adolescents
Authors: Claudia Mueller, Meredith L. Rowe, Barry Zuckerman
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Abstract P4-03-03: Microenvironment induced DDR2 mediates stromal-cancer interactions and metastasis growth in breast cancer
Authors: CG Kleer, EE Martin, T Anwar, C Arellano-Garcia, A Lama, N Medhora, Y-C Chen, E Yoon, C Ge, R Franceschi, ME Gonzalez
Journal: Cancer Research (2017)

Abstract This abstract was not presented at the symposium.
Interim Results of a Phase 1b/2 Study of Entospletinib (GS-9973) Monotherapy and in Combination with Chemotherapy in Patients with Acute Myeloid Leukemia
Authors: Alison R. Walker, Bhavana Bhatnagar, A. Mario Q. Marcondes, Julie DiPaolo, Sumithra Vasu, Alice S. Mims, Rebecca B. Klisovic, Katherine J. Walsh, Renee Canning, Gregory K. Behbehani, Ramiro Garzon, James S. Blachly, Amy J. Johnson, Esteban Abella-Dominicis, John C. Byrd, William Blum
Journal: Blood (2016)
Treating diabetic patients with chemotherapy: Single-center experience of toxicity and outcomes.
Authors: Jenny F. Seligmann, Alison Claire Young, Afroze Abbas, Alexander Newsham, David A. Cairns, Geoff Hall, Matthew T. Seymour, Daniel Swinson
Journal: Journal of Clinical Oncology (2014)

9643 Background: Epidemiological evidence suggests diabetics are at increased risk of several cancers, with inferior cancer outcomes. There is little data to describe the experience of diabetic patients during chemotherapy. We have compared outcomes of diabetic patient(pts) with non-diabetics receiving palliative chemotherapy for advanced colorectal cancer (aCRC) in a single centre. Methods: We performed a retrospective case note analysis between 2004 and 2011. Diabetic pts starting first line chemotherapy for aCRC were identified using an electronic patient record database (Patient Pathway Manager) and chemotherapy prescription software (ChemoCare). Data for chemotherapy regimen, acute admissions, subsequent therapy and survival were compared, corrected for age, performance status (PS), comorbidity and initial regimen (single vs combination agent). Results: 146 diabetic pts and 730 controls were included. Median age was 66 years; 94% of diabetic pts had type 2 diabetes, 17% were receiving insulin. Performance status was similar (PS 0-1in 76% in diabetics vs 77% controls); more diabetic pts had comorbidity (61% vs 25%). Diabetics received less upfront combination chemotherapy (OR = 0.41, 95% CI=0.29-0.65, p<0.001). Only 5% of diabetic pts had upfront steroid reduction. Diabetes was associated with an increased risk of acute admission (OR=2.35, 95%CI 1.6-3.45, p<0.0001). A higher incidence of infective episodes requiring hospitalisation were observed in diabetics (OR = 3.79, 95% CI 2.25-6.38, p<0.001). No other factors predicted for increased risk of admission. Poor glycaemic control led to admission in 6.9% of diabetics. Subsequent treatment with second line chemotherapy (p=0.87) and overall survival (p=0.21) was similar in both groups. Increased age and poor PS were independently prognostic for survival. Conclusions: Diabetic pts with aCRC achieved the same survival with palliative chemotherapy as non-diabetic patients. However diabetic pts receiving chemotherapy have over double the risk of an acute admission during treatment, despite reduced use of combination chemotherapy. Awareness of this risk and consideration of potential contributing factors may enable these episodes to be avoided.
Crystal Structure of Kunitz Domain 1 (KD1) of Tissue Factor Pathway Inhibitor-2 with Trypsin and Molecular Model of KD1 with Plasmin and Factor VIIa/Tissue Factor: Implications for KD1 Specificity of Inhibition.
Authors: Amy E. Schmidt, Hitendra S. Chand, Dulio Cascio, Walter Kisiel, S. Paul Bajaj
Journal: Blood (2004)
Predictive and Prognostic Significance of Comprehensive Genomic Profiling in Patients with Diffuse Large B-Cell Lymphoma
Authors: Jie He, Shan Zhong, Michelle Nahas, Mark Bailey, Jon Chung, Geoff Otto, Doron Lipson, Phil Stephens, Vincent A. Miller, Jeff Ross, Tariq I Mughal, Jo-Anne Vergilio
Journal: Blood (2015)
Nearly one in four cardiac arrests in pregnancy is due to anaesthesia, study finds
Authors: Susan Mayor
Journal: BMJ (2017)

Nearly a quarter of cardiac arrests occurring in pregnancy are caused by complications of obstetric anaesthesia, a prospective study of UK data has shown.1

Cardiac arrest occurs in around one in 30 000 pregnancies but may be rising with the increasing age and morbidity of pregnant women in the UK. Researchers prospectively analysed data from the UK Obstetric Surveillance System on all women who received basic life support in pregnancy from 1 July 2011 to 30 June 2014.

The results, reported in the British Journal of …
Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy
Authors: William D Rawlinson, Suresh B Boppana, Karen B Fowler, David W Kimberlin, Tiziana Lazzarotto, Sophie Alain, Kate Daly, Sara Doutré, Laura Gibson, Michelle L Giles, Janelle Greenlee, Stuart T Hamilton, Gail J Harrison, Lisa Hui, Cheryl A Jones, Pamela Palasanthiran, Mark R Schleiss, Antonia W Shand, Wendy J van Zuylen
Journal: The Lancet Infectious Diseases (2017)
Pleiotrophin Is Highly Produced by Solid Tumors and Transdifferentiates Human Monocytes Into Endothelial Cells.
Authors: Eric Wirtschafter, Emily Wong, Mingjie Li, Eric Sanchez, Cathy S Wang, Jennifer Li, Riley Kessler, Mengyin Hu, Crystal Leung, Zhi-Wei Li, Haiming Chen, Benjamin Bonavida, James R. Berenson
Journal: Blood (2009)
The Influence of State Laws on the Mental Health of Sexual Minority Youth
Authors: Mark L. Hatzenbuehler
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Engineering Photocrosslinkable Bicomponent Hydrogel Constructs for Creating 3D Vascularized Bone
Authors: Mehdi Kazemzadeh‐Narbat, Jeroen Rouwkema, Nasim Annabi, Hao Cheng, Masoumeh Ghaderi, Byung‐Hyun Cha, Mansi Aparnathi, Akbar Khalilpour, Batzaya Byambaa, Esmaiel Jabbari, Ali Tamayol, Ali Khademhosseini
Journal: Advanced Healthcare Materials (2017)

Engineering bone tissue requires the generation of a highly organized vasculature. Cellular behavior is affected by the respective niche. Directing cellular behavior and differentiation for creating mineralized regions surrounded by vasculature can be achieved by controlling the pattern of osteogenic and angiogenic niches. This manuscript reports on engineering vascularized bone tissues by incorporating osteogenic and angiogenic cell‐laden niches in a photocrosslinkable hydrogel construct. Two‐step photolithography process is used to control the stiffness of the hydrogel and distribution of cells in the patterned hydrogel. In addittion, osteoinductive nanoparticles are utilized to induce osteogenesis. The size of microfabricated constructs has a pronounced effect on cellular organization and function. It is shown that the simultaneous presence of both osteogenic and angiogenic niches in one construct results in formation of mineralized regions surrounded by organized vasculature. In addition, the presence of angiogenic niche improves bone formation. This approach can be used for engineered constructs that can be used for treatment of bone defects.
Abstract P1-05-16: An integrated molecular analysis of invasive lobular carcinoma
Authors: S Lal, A McCart Reed, K Nones, L Wockner, S Song, S Lakhani, P Simpson
Journal: Cancer Research (2017)

Abstract Background: Invasive lobular carcinoma (ILC) is the most commonly diagnosed special histological type of breast cancer, accounting for up to 15% of all cases. Accumulating data suggests the biology and clinical features of ILC differ to those of the more commonly diagnosed Invasive Carcinoma of No Special Type (IC-NST), including evidence of there being an overall worse long term outcome associated with ILC. Several large-scale molecular profiling studies have recently been published regarding ILC, highlighting molecular heterogeneity and important drivers of tumour behaviour. We hypothesize that an integrative analysis of gene expression and DNA copy number data will identify novel drivers, and prognostic and predictive biomarkers of lobular phenotype. Methods: Gene expression and copy number data from ILC tumours profiled in-house (n=25), METABRIC (n=125) and TCGA (n=145) were assembled and analysed. Integration of genome and transcriptome data was performed using two methods. Firstly, by Spearman correlation with a meta-analysis by combining gene level correlation coefficients from each study using a random effects model, weighting each study with inverse variance. Secondly using ANOVA, followed by combining gene level p-values across studies using Stouffers Z-score. Disease specific survival was examined at an individual gene level and using all genes simultaneously (via a Cox Boost analysis) to identify gene expression changes that are associated with poor outcome. Results: DNA copy number profiling identified recurrent gains (1q, 8q, 16p), losses (11q, 16q) and amplifications (1q32, 8p12-p11.2, 11q13). 11q13 amplifications were prevalent at a higher frequency in patients with poor outcome compared to patients with better outcome. The integrative analysis identified 1928 candidate genes whose expression was associated with gene copy number; as expected being enriched from genome regions highlighted above. One hundred and sixty of these genes were of prognostic significance in the METABRIC ILC cohort, several are known cancer drivers (e.g. PBX1, CCND1) and five new candidates are being investigated as novel prognostic biomarkers by immunohistochemistry. Conclusions: An integrated molecular analysis of ILC has identified a large number of gene expression changes that are dictated by gene copy number in ILC. Some of these are expected to influence tumour behavior and to highlight aggressive cancers with poor prognosis. Citation Format: Lal S, McCart Reed A, Nones K, Wockner L, Song S, Lakhani S, Simpson P. An integrated molecular analysis of invasive lobular carcinoma [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P1-05-16.
Assessment of Self-Administration of Romiplostim after Receipt of Home Administration Training Materials: A Cross-Sectional Study of Patients with Immune Thrombocytopenic Purpura and Caregivers
Authors: Martin Schipperus, Georgia D Kaiafa, Louise Taylor, Sally Wetten, James Bennett, Georg Kreuzbauer, Andy Boshier, Anouchka Seesaghur
Journal: Blood (2016)
Tackling alcohol use: screening, target group, and patient centred care
Authors: Sven B Andréasson
Journal: BMJ (2017)

McCambridge and Saitz have written an excellent review on brief interventions for alcohol in primary care.1 Given the substantial harm caused by alcohol, it still makes good sense for practitioners to discuss alcohol and other drugs with their patients. But how?

To begin with, screening needs to change. Practitioners have …