tbuckley/cabot-search huggingface dataset:
Proyecto EUVAC-NET: creación y funcionamiento de una red de vigilancia comunitaria de las enfermedades infecciosas prevenibles por la vacunación
Authors: S Glismann, T Rønne, A E Tozzi
Journal: Eurosurveillance (2001)

La red EUVAC-NET se ocupa de la vigilancia epidemiologica y del control de las enfermedades prevenibles por la vacunacion. Su coordinacion esta a cargo del SSI de Dinamarca, en colaboracion con el ISS de Italia. Las dos enfermedades principales en las que se centra la red son el sarampion y la tos ferina. Esta previsto contar con la colaboracion del PHLS para la vigilancia de Haemophilus influenzae b. EUVAC-NET esta formada por los Estados Miembros de la Union Europea, asi como por Islandia, Noruega y Suiza.
Give GPs more time with patients, urges RCGP chair
Authors: Abi Rimmer
Journal: BMJ (2017)

GPs need more time to care for their patients, the chair of the Royal College of General Practitioners has said, adding that she would call on the four UK governments to cut bureaucracy to allow this.

Speaking at the college’s annual conference in Liverpool on 12 October, Helen Stokes-Lampard also said, “GPs see patients, many of whom are widowed, who have multiple health problems like diabetes, hypertension, and depression. But often their main problem isn’t medical: …
Similar clinical benefits from below‐target and target dose enalapril in patients with heart failure in the SOLVD Treatment trial
Authors: Phillip H. Lam, Daniel J. Dooley, Gregg C. Fonarow, Javed Butler, Deepak L. Bhatt, Gerasimos S. Filippatos, Prakash Deedwania, Daniel E. Forman, Michel White, Ross D. Fletcher, Cherinne Arundel, Marc R. Blackman, Chris Adamopoulos, Ioannis E. Kanonidis, Inmaculada B. Aban, Kanan Patel, Wilbert S. Aronow, Richard M. Allman, Stefan D. Anker, Bertram Pitt, Ali Ahmed
Journal: European Journal of Heart Failure (2017)
ATM loss, MSI and survival in the MAGIC trial
Authors: E. Smyth, M. Fassan, K. Kouvelakis, M. Nankivell, C. Peckitt, A. Wotherspoon, N. Valeri, M. Rugge, W. Allum, R. Langley, D. Cunningham
Journal: Annals of Oncology (2017)
Alignment-free sequence comparison: benefits, applications, and tools
Authors: Andrzej Zielezinski, Susana Vinga, Jonas Almeida, Wojciech M. Karlowski
Journal: Genome biology (2017)

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. The strength of these methods makes them particularly useful for next-generation sequencing data processing and analysis. However, many researchers are unclear about how these methods work, how they compare to alignment-based methods, and what their potential is for use for their research. We address these questions and provide a guide to the currently available alignment-free sequence analysis tools.
School closure is currently the main strategy to mitigate influenza A(H1N1)v: a modeling study
Authors: V Sypsa, A Hatzakis
Journal: Eurosurveillance (2009)

Concerns about an imminent influenza pandemic have been intensified after the emergence of the new influenza A(H1N1)v strain. Mathematical modeling was employed on recent epidemiological data from Mexico in order to assess the impact of intervention strategies on the spread of influenza A(H1N1)v in the setting of the European region. When initiating the intervention of 100% school closure in a community of 2,000 people at a threshold of 1% cumulative attack rate, the total number of symptomatic cases is predicted to decrease by 89.3%, as compared to the non-intervention scenario. When this measure is coupled with treatment and home isolation of symptomatic cases as well as a 50% reduction of social contacts, a 94.8% decline in the cumulative attack rate is predicted along with a much shorter duration of influenza A(H1N1)v transmission. Active surveillance that will ensure timely treatment and home isolation of symptomatic cases in combination with school closure seem to form an efficient strategy to control the spread of influenza A(H1N1)v.
Cell-Cycle and DNA-Damage Response Pathway Is Involved in Leptomeningeal Metastasis of Non–Small Cell Lung Cancer
Authors: Yun Fan, Xuehua Zhu, Yan Xu, Xuesong Lu, Yanjun Xu, Mengzhao Wang, Haiyan Xu, Jingyan Ding, Xin Ye, Luo Fang, Zhiyu Huang, Lei Gong, Hongyang Lu, Weimin Mao, Min Hu
Journal: Clinical Cancer Research (2017)

Purpose: Leptomeningeal metastasis (LM) is a detrimental complication of non-small cell lung cancer (NSCLC) and associated with poor prognosis. However, the underlying mechanisms of the metastasis process are still poorly understood.Experimental Design: We performed next-generation panel sequencing of primary tumor tissue, cerebrospinal fluid (CSF), and matched normal controls from epidermal growth factor receptor (EGFR) mutation-positive NSCLC patients with LM.Results: The status of EGFR-activating mutations was highly concordant between primary tumor and CSF. PIK3CA aberrations were high in these patients, implicating an association with LM risk. Intriguingly, low overlapping of somatic protein-changing variants was observed between paired CSF and primary lesions, exhibiting tumor heterogeneity and genetic divergence. Moreover, genes with CSF-recurrent genomic alterations were predominantly involved in cell-cycle regulation and DNA-damage response (DDR), suggesting a role of the pathway in LM development.Conclusions: Our study has shed light on the genomic variations of NSCLC-LM, demonstrated genetic heterogeneity and divergence, uncovered involvement of cell-cycle and DDR pathway, and paved the way for potential therapeutic approaches to this unmet medical need. Clin Cancer Res; 24(1); 209-16. ©2017 AACR.
Deep endoscopic submucosal dissection of a refractory tracheoesophageal fistula using clip-and-line traction: a successful closure
Authors: Gaspard Bertrand, Jérémie Jacques, Jérôme Rivory, Florian Rostain, Jean-Christophe Saurin, Thierry Ponchon, Mathieu Pioche
Journal: Endoscopy (2017)

Chronic tracheoesophageal fistula is a rare disease presenting a therapeutic challenge. Unlike the case with most digestive fistulas, drainage with a pigtail stent [1] is not possible.
Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity
Authors: Kaisa M. Kemppainen, Kendra Vehik, Kristian F. Lynch, Helena Elding Larsson, Ronald J. Canepa, Ville Simell, Sibylle Koletzko, Edwin Liu, Olli G. Simell, Jorma Toppari, Anette G. Ziegler, Marian J. Rewers, Åke Lernmark, William A. Hagopian, Jin-Xiong She, Beena Akolkar, Desmond A. Schatz, Mark A. Atkinson, Martin J. Blaser, Jeffrey P. Krischer, Heikki Hyöty, Daniel Agardh, Eric W. Triplett
Journal: JAMA Pediatrics (2017)

<h3>Importance</h3> Evidence is lacking regarding the consequences of antibiotic use in early life and the risk of certain autoimmune diseases. <h3>Objective</h3> To test the association between early-life antibiotic use and islet or celiac disease (CD) autoimmunity in genetically at-risk children prospectively followed up for type 1 diabetes (T1D) or CD. <h3>Design, Setting, and Participants</h3> HLA-genotyped newborns from Finland, Germany, Sweden, and the United States were enrolled in the prospective birth cohort of The Environmental Determinants of Diabetes in the Young (TEDDY) study between November 20, 2004, and July 8, 2010. The dates of analysis were November 20, 2004, to August 31, 2014. Individuals from the general population and those having a first-degree relative with T1D were enrolled if they had 1 of 9 HLA genotypes associated with a risk for T1D. <h3>Exposures</h3> Parental reports of the most common antibiotics (cephalosporins, penicillins, and macrolides) used between age 3 months and age 4 years were recorded prospectively. <h3>Main Outcomes and Measures</h3> Islet autoimmunity and CD autoimmunity were defined as being positive for islet or tissue transglutaminase autoantibodies at 2 consecutive clinic visits at least 3 months apart. Hazard ratios and 95% CIs calculated from Cox proportional hazards regression models were used to assess the relationship between antibiotic use in early life before seroconversion and the development of autoimmunity. <h3>Results</h3> Participants were 8495 children (49.0% female) and 6558 children (48.7% female) enrolled in the TEDDY study who were tested for islet and tissue transglutaminase autoantibodies, respectively. Exposure to and frequency of use of any antibiotic assessed in this study in early life or before seroconversion did not influence the risk of developing islet autoimmunity or CD autoimmunity. Cumulative use of any antibiotic during the first 4 years of life was not associated with the appearance of any autoantibody (hazard ratio [HR], 0.98; 95% CI, 0.95-1.01), multiple islet autoantibodies (HR, 0.99; 95% CI, 0.95-1.03), or the transglutaminase autoantibody (HR, 1.00; 95% CI, 0.98-1.02). <h3>Conclusions and Relevance</h3> The use of the most prescribed antibiotics during the first 4 years of life, regardless of geographic region, was not associated with the development of autoimmunity for T1D or CD. These results suggest that a risk of islet or tissue transglutaminase autoimmunity need not influence the recommendations for clinical use of antibiotics in young children at risk for T1D or CD.
“Liquid Withdarw” technique prominently reduced the incidence of pneumothorax and improved tumor tissue amount of CT-guided cutting needle lung biopsy: A retrospective study
Authors: R. Li, W. Ren, J. Gao, Y. Zhang, P. Jiang, X. Zhou, H. Zhang, X. Shen, J. Liu, S. Gao, L. Wang, B. Liu
Journal: Annals of Oncology (2017)
Patients (pts) with metastatic non-clear cell renal cell carcinoma (mnccRCC) treated with Nivolumab (Nivo) based immunotherapy as advanced treatment (ATL) line: analysis of a national early access program (EAP)
Authors: A. Peer, K. Savion, K. Rouvinov, R. Leibowitz-Amit, R. Berger, A. Sella, V. Neiman, E. Rosenbaum, W. Mermershtain, A. Neumann, M. Kolin, R. Perets, D. Keizman
Journal: Annals of Oncology (2017)
EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming
Authors: Remi Adelaiye-Ogala, Justin Budka, Nur P. Damayanti, Justine Arrington, Mary Ferris, Chuan-Chih Hsu, Sreenivasulu Chintala, Ashley Orillion, Kiersten Marie Miles, Li Shen, May Elbanna, Eric Ciamporcero, Sreevani Arisa, Piergiorgio Pettazzoni, Giulio F. Draetta, Mukund Seshadri, Bradley Hancock, Milan Radovich, Janaiah Kota, Michael Buck, Heike Keilhack, Brian P. McCarthy, Scott A. Persohn, Paul R. Territo, Yong Zang, Joseph Irudayaraj, W. Andy Tao, Peter Hollenhorst, Roberto Pili
Journal: Cancer Research (2017)

Acquired and intrinsic resistance to receptor tyrosine kinase inhibitors (RTKi) represents a major hurdle in improving the management of clear cell renal cell carcinoma (ccRCC). Recent reports suggest that drug resistance is driven by tumor adaptation via epigenetic mechanisms that activate alternative survival pathways. The histone methyl transferase EZH2 is frequently altered in many cancers, including ccRCC. To evaluate its role in ccRCC resistance to RTKi, we established and characterized a spontaneously metastatic, patient-derived xenograft model that is intrinsically resistant to the RTKi sunitinib, but not to the VEGF therapeutic antibody bevacizumab. Sunitinib maintained its antiangiogenic and antimetastatic activity but lost its direct antitumor effects due to kinome reprogramming, which resulted in suppression of proapoptotic and cell-cycle-regulatory target genes. Modulating EZH2 expression or activity suppressed phosphorylation of certain RTKs, restoring the antitumor effects of sunitinib in models of acquired or intrinsically resistant ccRCC. Overall, our results highlight EZH2 as a rational target for therapeutic intervention in sunitinib-resistant ccRCC as well as a predictive marker for RTKi response in this disease. Cancer Res; 77(23); 6651-66. ©2017 AACR.
Initial results from AQUARiUS, a prospective, observational, multi-centre phase IV study assessing patient-reported outcomes (PROs) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) treated with abiraterone acetate plus prednisone (AAP) or enzalutamide (ENZ)
Authors: A. Thiery-Vuillemin, M.H. Poulsen, A. Reid, E. Lagneau, G. Ploussard, A. Birtle, L.M. Dourthe, D. Beal-Ardisson, E. Pintus, R. Trepiakas, M. Lukac, S. Van Sanden, L. Dearden
Journal: Annals of Oncology (2017)
Independent predictors of one year mortality in patients with primary systemic immunoglobulin light chain cardiac amyloidosis
Authors: V. Srinivasalu, M. Subramaniam, A. Shanmugam, A. Philip, A. Susan, R. Prabhu, M. Unni, N. Sidharthan, W. Jose, S. N V, H. Ahamed, N. Mathew, P. Keechilat
Journal: Annals of Oncology (2017)
Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice
Authors: Yogi Umbarawan, Mas Rizky A A Syamsunarno, Norimichi Koitabashi, Aiko Yamaguchi, Hirofumi Hanaoka, Takako Hishiki, Yoshiko Nagahata-Naito, Hideru Obinata, Motoaki Sano, Hiroaki Sunaga, Hiroki Matsui, Yoshito Tsushima, Makoto Suematsu, Masahiko Kurabayashi, Tatsuya Iso
Journal: Cardiovascular Research (2018)

The metabolism of the failing heart is characterized by an increase in glucose uptake with reduced fatty acid (FA) oxidation. We previously found that the genetic deletion of FA-binding protein-4 and -5 [double knockout (DKO)] induces an increased myocardial reliance on glucose with decreased FA uptake in mice. However, whether this fuel switch confers functional benefit during the hypertrophic response remains open to debate. To address this question, we investigated the contractile function and metabolic profile of DKO hearts subjected to pressure overload.Transverse aortic constriction (TAC) significantly reduced cardiac contraction in DKO mice (DKO-TAC), although an increase in cardiac mass and interstitial fibrosis was comparable with wild-type TAC (WT-TAC). DKO-TAC hearts exhibited enhanced glucose uptake by 8-fold compared with WT-TAC. Metabolic profiling and isotopomer analysis revealed that the pool size in the TCA cycle and the level of phosphocreatine were significantly reduced in DKO-TAC hearts, despite a marked increase in glycolytic flux. The ingestion of a diet enriched in medium-chain FAs restored cardiac contractile dysfunction in DKO-TAC hearts. The de novo synthesis of amino acids as well as FA from glycolytic flux was unlikely to be suppressed, despite a reduction in each precursor. The pentose phosphate pathway was also facilitated, which led to the increased production of a coenzyme for lipogenesis and a precursor for nucleotide synthesis. These findings suggest that reduced FA utilization is not sufficiently compensated by a robust increase in glucose uptake when the energy demand is elevated. Glucose utilization for sustained biomass synthesis further enhances diminishment of the pool size in the TCA cycle.Our data suggest that glucose is preferentially utilized for biomass synthesis rather than ATP production during pressure-overload-induced cardiac hypertrophy and that the efficient supplementation of energy substrates may restore cardiac dysfunction caused by energy insufficiency.
Progression-free survival (PFS) and site of first progression in HER2+ metastatic breast cancer (MBC) patients (pts) with (w) or without (w/o) brain metastases: A pooled analysis of tucatinib phase I studies
Authors: S. Moulder, E. Hamilton, C. Ferrario, A. Conlin, I. Krop, M. Chamberlain, T. Gray, V. Borges
Journal: Annals of Oncology (2017)
Deliberative democracy and cancer screening. The use of citizens' s juries in health policy decision-making
Authors: A. Cutillas, P. Rosado-Varela, V. Luque-Ribelles, S. Márquez Calderón, E. Benitez-Rodríguez, J.M. Ribera-Bautista, J.M. Baena-Canada
Journal: Annals of Oncology (2017)
Diagnostico microbiológico de la borreliosis de Lyme en el Instituto Nacional de Salud Pública de Portugal (1990-2004)
Authors: I Lopes de Carvalho, M S Núncio
Journal: Eurosurveillance (2006)

La borreliosis de Lyme se considera como una enfermedad emergente en ciertas partes del mundo, incluyendo Portugal. En este pais, el primer caso humano de borreliosis de Lyme se identifico en 1989. Desde 1999, esta enfermedad es de declaracion obligatoria en Portugal, pero son pocos los casos declarados cada ano, lo que dificulta el analisis de los factores de riesgo y la evaluacion del impacto en salud publica. Para este estudio, los autores analizaron los datos disponibles en el Centro de estudios de los vectores y enfermedades infecciosas (CEVDI), en el Instituto nacional de salud Dr Ricardo Jorge (INSA) de los 15 ultimos anos (1990-2004), comparandolos con los casos declarados en el registro nacional (1999-2004). El diagnostico de laboratorio se basaba en pruebas serologicas. Se dispone de los datos sobre el ano de diagnostico, el sexo, la edad, el origen geografico y los sintomas clinicos para 628 casos portugueses confirmados. El numero anual de casos variaba entre dos y 78, el numero maximo de casos se declaro en 1997. Entre los casos positivos, el 53,5% eran mujeres y el grupo de edad mas afectado fue el de 35-44 anos. La neuroborreliosis fue la manifestacion clinica mas frecuente (37,3%). Se detectaron casos en 17 de las 20 regiones geograficas de Portugal, con el mayor numero de casos confirmados por laboratorio en la region de Lisboa. La comparacion entre el numero de casos declarados y el numero de casos confirmados por nuestro laboratorio muestra claramente que la borreliosis de Lyme es una enfermedad sub-notificada. Debido a la dispersion de los casos y a la baja prevalencia de la especie Ixodes ricinus, la medida de prevencion mas eficaz para luchar contra la borreliosis de Lyme en Portugal sigue siendo informar a los grupos de riesgo sobre las medidas de prevencion de las picaduras de garrapatas.
GW28-e1224 Rotational Sources and Continuous Activities Partially Localize to Regions of Delayed Enhancement and Low Voltage of left atrium in Persistent Atrial Fibrillation
Authors: Juan Chen, Thomas Arentz, Heiko Lehrmann, Steven J. Kim, Viktor Markstein, Dietmar Trenk, Bjoern Mueller-Edenborn, Reinhold Weber, Juergen Allgeier, Franz-Josef Neumann, Mélèze Hocini, Pierre Jais, Michel Haïssaguerre, Ling Shao, Yafeng Chen, Jun Yi, Amir Jadidi
Journal: Journal of the American College of Cardiology (2017)
SRC-S6 axis as a potential mechanism of resistance to anti HER2 treatment in gastric cancer (GC) cell lines
Authors: V. Gambardella, A. Sampera, J. Castillo, F. Sánchez-Martín, F. Gimeno-Valiente, N. Tarazona, D. Roda, A. Rovira, M. Rosello, J. Albanell, C. Montagut, A. Cervantes
Journal: Annals of Oncology (2017)
A Phase I safety study of topical Calcitriol (BPM 31543) for the prevention of chemotherapy-induced alopecia (CIA)
Authors: B. Berman, J. Konner, V.R. Belum, H. Dion, K. Ciccolini, S. Kitts, R. Ye, S. Ravipaty, V.R. Akmaev, R. Sarangarajan, J.J. Jimenez, N. Narain, S.B. Goldfarb, M.E. Lacouture
Journal: Annals of Oncology (2017)
Computer extracted features of nuclear architecture in H&E sections to predict disease recurrence in oropharyngeal squamous cell carcinoma patients.
Authors: Cheng Lu, James Lewis, Anant Madabhushi
Journal: Journal of Clinical Oncology (2017)

e17536 Background: Most patients with oropharyngeal squamous cell carcinoma (OPSCC) are cured of their disease but 10-20% will develop recurrence. Identifying high risk patients is key to tailoring therapy and reducing treatment-related morbidity. In this study, we present initial findings using computerized analysis of local nuclear architecture from digitized H&amp;E tissue sections of OPSCC via a new algorithm called cell run-length features (CRF) to distinguish patients with more versus less aggressive disease. Methods: H&amp;E stained tissue microarray sections of 160 primary p16+ OPSCC were digitally scanned. Our CRF analysis involved 1) nuclei segmentation, 2) creation of local cell cluster graphs based on proximity of nuclei, and 3) computing CRF for each cell cluster graph. The CRF reflects the total number of different ways/runs that the graph vertices can be traversed. A higher CRF reflects more complex nuclear spatial architecture, while a lower CRF reflects the converse. A series of CRF features relating to statistics of the graph runs across the image are then extracted,. The top 5 predictive features were identified via Wilcoxon Rank Sum Test and then evaluated in conjunction with a binary quadratic classifier via 5-fold cross validation. Results: The top ranked features were related to CRF non-uniformity (i.e. reflecting the variation of complexity of different nuclei clusters) and the classifier yielded a mean area under the receiver operating characteristic curve of 0.75 in discriminating patients who did and did not have disease progression. Patients with high risk CRF values were 5.7 times more likely to suffer disease recurrence than those without. While the whole cohort had a disease recurrence rate of 12.5%, those with low CRF values developed recurrence in only 1.875%. Conclusions: CRF features demonstrate a strong association with disease recurrence in patients with p16 positive OPSCC. Our preliminary findings suggest that measurements related to local arrangement of nuclei have potential in the risk assessment of patients with p16 positive OPSCC. The findings will need to be independently validated in a separate, powered cohort of patients.
Occurrence of Salmonella Enteritidis phage type 29 in Austria : an opportunity to assess the relevance of chicken meat as source of human salmonella infections
Authors: C Berghold, C. Kornschober, I Lederer, F Allerberger
Journal: Eurosurveillance (2004)

Assuming that the various phage types of Salmonella Enteritidis (S. Enteritidis) are largely equally virulent, the importance of certain foods as sources of infection for human salmonellosis can be deduced from differences in the distribution of phage types in human and non-human samples. In 2002, S. Enteritidis phage type 29 (PT29) was first isolated from non-human test samples in Austria. S. Enteritidis PT29 accounted for 44 (27.7%) of 159 S. Enteritidis strains, derived from veterinary samples of chicken (e.g. meat, giblets) or chicken habitations (e.g. swabs from the coop and excrement). At the food retail level (chicken meat, chicken liver), five (13.1%) of 38 S. Enteritidis isolates were PT29. The proportion of S. Enteritidis PT29 in human samples was much lower. Only 0.4% (30 human primary isolates) of all S. Enteritidis isolates in the year 2002, and 0.33% (23 human primary isolates) of all human S. Enteritidis strains in 2003 were PT29. In our opinion, the discrepancy between the high prevalence of S. Enteritidis PT29 in broilers and chicken meat and the low number of PT29 cases in humans indicates that chicken meat of Austrian origin is currently only a minor source of human S. Enteritidis infections.