First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials
Authors: Harpreet S Wasan, Peter Gibbs, Navesh K Sharma, Julien Taieb, Volker Heinemann, Jens Ricke, Marc Peeters, Michael Findlay, Andrew Weaver, Jamie Mills, Charles Wilson, Richard Adams, Anne Francis, Joanna Moschandreas, Pradeep S Virdee, Peter Dutton, Sharon Love, Val Gebski, Alastair Gray, Guy van Hazel, Ricky A Sharma, Richard Adams, Andrew Bateman, Claire Blesing, Ewan Brown, Ian Chau, Sebastian Cummins, David Cunningham, Stephen Falk, Maher Hadaki, Marcia Hall, Tamas Hickish, Joanne Hornbuckle, Fiona Lofts, Sarah Lowndes, Astrid Mayer, Matthew Metcalfe, Gary Middleton, Jamie Mills, Amir Montazeri, Rebecca Muirhead, Andreas Polychronis, Colin Purcell, Paul Ross, Ricky A Sharma, Liz Sherwin, David Smith, Rubin Soomal, Daniel Swinson, Axel Walther, Harpreet Wasan, Andrew Weaver, Charles Wilson, Greg Wilson, Pradip Amin, Bruna Angelelli, Jacques Balosso, Alex Beny, Daniel Bloomgarden, Evelyn Boucher, Michael Brown, Harald-Robert Bruch, James Bui, Matthew Burge, Giuseppe Cardaci, James Carlisle, Seungjean Chai, Yi-Jen Chen, Patrick Chevallier, Michael Chuong, Stephen Clarke, Andrew Coveler, Michael Craninx, Thierry Delanoit, Amélie Deleporte, Paul Eliadis, Francis Facchini, Thomas Ferguson, Michel Ferrante, Michael Findlay, Gary Frenette, Jacob Frick, Vinod Ganju, Michael Garofalo, Karen Geboes, Gerald Gehbauer, Benjamin George, Ravit Geva, Peter Gibbs, Michael Gordon, Kate Gregory, Seza Gulec, James Hannigan, Guy van Hazel, Norman Heching, Volker Heinemann, Thomas Helmberger, Alain Hendlisz, Koen Hendrickx, Matthew Holtzman, Richard Isaacs, Christopher Jackson, Philip James, Adeel Kaiser, Chris Karapetis, Andreas Kaubisch, Yon-Dschun Ko, Hendrik Kröning, Frank Lammert, Winston Liauw, Steven Limentani, Samy Louafi, Marc de Man, Jeffrey Margolis, Robert Martin, Andrea Martoni, Gavin Marx, Marco Matos, Els Monsaert, Veerle Moons, Louise Nott, Arnd Nusch, Anne O'Donnell, Howard Ozer, Siddarth Padia, Nick Pavlakis, Marc Peeters, David Perez, Stefan Pluntke, Marc Polus, Alex Powell, Marc Pracht, Timothy Price, David Ransom, Christine Rebischung, Jens Ricke, Karsten Ridwelski, Jorge Riera-Knorrenschild, Hanno Riess, William Rilling, Bridget Robinson, Javier Rodríguez, Federico Sanchez, Tilmann Sauerbruch, Michael Savin, Klemens Scheidhauer, Elyse Schneiderman, Grant Seeger, Eva Segelov, Einat Shaham Schmueli, Adi Shani, Jenny Shannon, Navesh Sharma, Stephen Shibata, Nimit Singhal, Denis Smith, Randall Smith, Salomon Stemmer, Oliver Stötzer, Andrew Strickland, Julien Taieb, Klaus Tatsch, Eric Terrebonne, Thomas Tichler, Ursula Vehling-Kaiser, Ruth Vera-Garcia, Thomas Vogl, Euan Walpole, Eric Wang, Samuel Whiting, Ido Wolf, Steven Ades, Morteza Aghmesheh, Bruna Angelelli, Miklos Auber, Hubert Ayala, Alex Beny, Daniel Bloomgarden, Patrick Boland, Eveline Bouche, Charles Bowers, Christoph Bremer, James Bui, Mathew Burge, James Carlisle, Ana Ruiz Casado, Seungjean Chai, Michael Chuong, Prasad Cooray, Martin Crain, Maike De Wit, Kyran Dowling, Aurelie Durand, Francis Facchini, Sandrine Faivre, Kynan Feeney, Tom Ferguson, Aurelie Ferru, Michael Findlay, Maria Fragoso, Gary Frenette, Jacob Frick, Vinod Ganju, Ravit Geva, Peter Gibbs, Cristina Granetto, Pascal Hammel, Guy van Hazel, Norman Heching, Alain Hendlisz, Koen Hendrickx, Matthew Holtzman, Richard Issacs, Renuka Iyer, Christopher Jackson, Adeel Kaiser, Andreas Kaubisch, Yeul Hong Kim, Hendrik Kröning, Jin Tung Liang, Lionel Lim, Steven Limentani, Jin Hwang Liu, Samy Louafi, Marc de Man, Gianluca Masi, Marco Matos, Els Monsaert, Stefania Mosconi, Louise Nott, Gianmauro Numico, Anne O'Donnell, Marc Peeters, Marc Polus, Marc Pracht, Lynn Ratner, Christine Rebischung, Han Sae-Won, Federico Sanchez, Adi Shani, Navesh Sharma, Madhu Singh, Nimit Singhal, Denis Smith, Patricia Stoltzfus, Andrew Strickland, Julien Taieb, Iain Tan, Eric Terrebonne, Thomas Tichler, Antonio Trogu, Craig Underhill, Ruth Vera-Garcia, Euan Walpole, Eric Wang, Mark Westcott
Journal: The Lancet Oncology (2017)

Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit in patients with colorectal liver metastases with liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy with SIRT using yttrium-90 resin microspheres in patients with metastatic colorectal cancer with liver metastases. The studies were designed for combined analysis of overall survival.