AntiCyclic Citrullinated Peptide Antibodies in Advanced Rheumatoid Arthritis
Authors: Geraldo Castelar Pinheiro, Morton A. Scheinberg, Miriam Aparecida da Silva, Suely Maciel
Journal: Annals of Internal Medicine (2003)

Letters5 August 2003Anti–Cyclic Citrullinated Peptide Antibodies in Advanced Rheumatoid ArthritisGeraldo Castelar Pinheiro, MD, Morton A. Scheinberg, MD, PhD, Miriam Aparecida da Silva, BS, and Suely Maciel, BSGeraldo Castelar Pinheiro, MDUniversidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. Laboratory; Sao Paulo, Brazil (Aparecida da Silva, Maciel), Morton A. Scheinberg, MD, PhDUniversidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. Laboratory; Sao Paulo, Brazil (Aparecida da Silva, Maciel), Miriam Aparecida da Silva, BSUniversidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. Laboratory; Sao Paulo, Brazil (Aparecida da Silva, Maciel), and Suely Maciel, BSUniversidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. Laboratory; Sao Paulo, Brazil (Aparecida da Silva, Maciel)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-3-200308050-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Rheumatoid arthritis is a chronic systemic autoimmune disease of unknown cause. There is growing evidence that therapeutic intervention early in the disease course leads to better control and less joint damage. With more sophisticated types of therapy becoming available, it is now even more important to definitively diagnose rheumatoid arthritis at an early stage so that treatment can be administered sooner and major damage of joint tissue can be prevented (1). A disease-specific autoantibody that could be used as a serologic marker of the disease would be very useful.Rheumatoid factor combined with clinical findings has ...References1. Keystone E. Treatments no longer in development for rheumatoid arthritis. Ann Rheum Dis. 2002;61 Suppl 2 ii43-5. [PMID: 12379620] CrossrefMedlineGoogle Scholar2. Bizzaro N, Mazzanti G, Tonutti E, Villalta D, Tozzoli R. Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis. Clin Chem. 2001;47:1089-93. [PMID: 11375296] CrossrefMedlineGoogle Scholar3. Kroot EJ, de Jong BA, van Leeuwen MA, Swinkels H, van den Hoogen FH, van't Hof M, . The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 2000;43:1831-5. [PMID: 10943873] CrossrefMedlineGoogle Scholar4. van der Heijde DM, van 't Hof M, van Riel PL, van de Putte LB. Development of a disease activity score based on judgment in clinical practice by rheumatologists. J Rheumatol. 1993;20:579-81. [PMID: 8478878] MedlineGoogle Scholar5. Pinheiro GR, Andrade CA, Gayer CR, Coelho MS, Freire SM, Scheinberg MA. Serum vascular endothelial growth factor in late rheumatoid arthritis. Clin Exp Rheumatol. 2001;19:721-3. [PMID: 11791646] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Universidade Estadual do Rio de Janeiro; Rio de Janeiro, Brazil (Castelar, Pinheiro)Hospital Israelita Albert Einstein; Sao Paulo, Brazil (Scheinberg)L.I.D. Laboratory; Sao Paulo, Brazil (Aparecida da Silva, Maciel) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFrom Rheumatoid Factor to Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies for Diagnosis and Prognosis Prediction in Patients with Rheumatoid ArthritisAnti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis: Biological Effects and Mechanisms of ImmunopathogenesisComplement in the Initiation and Evolution of Rheumatoid ArthritisA large chronic pericardial effusion in an ultramarathon runner with anti-CCP positive rheumatoid arthritisSerum Biomarkers for Discrimination between Hepatitis C-Related Arthropathy and Early Rheumatoid ArthritisCOEXISTENT TOPHACEOUS GOUT AND RHEUMATOID ARTHRITIS : A CASE REPORTAntibodies to citrullinated peptides: a significant step forward in the early diagnosis of rheumatoid arthritisImpact of Treatment with Infliximab on Anticyclic Citrullinated Peptide Antibody and Rheumatoid Factor in Patients with Rheumatoid ArthritisRole of anticyclic citrullinated peptide 2 assay in long-standing rheumatoid arthritisUse and significance of anti-CCP autoantibodies in rheumatoid arthritisThe clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritisAntibodies to Cyclic Citrullinated Peptide in Patients With Chronic Arthritis Attending an Arthritis-Monitoring ClinicDiagnostic Performance and Predictive Value of Rheumatoid Factor, Anti-citrullinated Peptide Antibodies, and the HLA Shared Epitope for Diagnosis of Rheumatoid ArthritisDiagnostik und Prognostik der frühen rheumatoiden Arthritis unter besonderer Berücksichtigung der Labor-Analytik Diagnosis and prognosis of early rheumatoid arthritis, with special emphasis on laboratory analysisUpdate on autoantibodies in rheumatoid arthritis 5 August 2003Volume 139, Issue 3Page: 234-235KeywordsAntibodiesArginineAutoantibodiesAutoimmune diseasesDigestionDrugsEnzyme linked immunosorbent assayInfectious diseasesPathogenesisRheumatoid arthritis ePublished: 5 August 2003 Issue Published: 5 August 2003 CopyrightCopyright © 2003 by American College of Physicians. 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