tbuckley/cabot-search huggingface dataset:
Four Versus Two Years of Rituximab Maintenance (R-maintenance) Following Bendamustine Plus Rituximab (B-R): Initial Results of a Prospective, Randomized Multicenter Phase 3 Study in First-Line Follicular Lymphoma (the StiL NHL7-2008 MAINTAIN study)
Authors: Mathias J Rummel, Christian Buske, Bernd Hertenstein, Christian Lerchenmüller, Michael Koenigsmann, Elisabeth Lange, Manfred Reeb, Ulrich Kaiser, Christina Balser, Dirk Behringer, Jan Dürig, Tobias Gaska, Georg Maschmeyer, Georg Schliesser, Alexander Christoph Burchardt, Juergen Barth, Frank Kauff, Axel Hinke, Richard Greil
Journal: Blood (2018)
FULFILMENT OF COLONOSCOPY QUALITY INDICATORS
Authors: C Mangas, E Santana, J Cubiella, A Suárez, I Portillo, A Seoane, M Ponce, P Díez, E Quintero, M Herráiz, M Pellisé, Á Fernández, V Hernández, Á Pizarro, R Jover
Journal: Endoscopy (2018)

Colonoscopy plays a key role in prevention and diagnosis of colorectal cancer (CRC), and it's quality influences the amount of interval cancer. However, we have little information on quality compliance standards in Spain. The aim was to evaluate the fulfilment of colonoscopy quality indicators in a sample of centres in Spain.
ANALYZING THE EFFECTIVENESS AND SAFETY OF THE COMBINATION OF EUS-GBD WITH ERCP AT THE SAME SESSION
Authors: R Torres, J Garcia-Alonso, A Carbajo, N Mora, M Cimavilla, R Sanchez-Ocaña, C De la Serna, M Pérez-Miranda
Journal: Endoscopy (2018)

Unicentric cohorts’ retrospective study comparing patients with EUS-GBD with patients with ERCP and EUS-GBD at the same session between June 2011 and May 2017. Axios® lumen apposition stent were employed in both groups. Exclusion criteria: ERCP or EUS-GBD for rescue of the other procedure, EUS-guided biliary drainage in the same session, another ERCP 5 days after or before the EUS-GBD.
DIGITAL SINGLE-OPERATOR VIDEO PANCREATOSCOPY (SPYGLASSDS) WITH LITHOTRIPSY IN CHRONIC CALCIFYING PANCREATITIS WITH OBSTRUCTING STONE OF THE MAIN PANCREATIC DUCT: RETROSPECTIVE SERIES OF 23 CASES
Authors: G Christian, D Pullmann, P Siersema, E van Geenen, H Neuhaus, T Beyna
Journal: Endoscopy (2018)

The role of per oral pancreatoscopy (POP) in pancreatic duct (PD) stone treatment is still not clear and ESWL is still the gold standard in non-surgical treatment. Since 2015 single-operator video cholangio-/pancreatoscopy system is available. Our aim was to present the so far largest series of dedicated POP guided PD-Stone lithotripsy using SpyGlassDS.
Comparision of linear EUS and ERCP for patients with clinically suspicious bile duct stones that not detected in the Abdominal CT
Authors: Kim Tae Hyeon
Journal: Endoscopy (2011)

Backgrounds/Aims: Endoscopic retrograde cholangiopancreatography (ERCP) is being replaced by endoscopic ultrasonography (EUS) for diagnostic purposes in the pancreatobiliary disease, and it should be reserved for therapeutic indication. We investigated diagnostic accuracy, complications and benefits of an EUS-guided approach versus an ERCP-guided approach in patients with suspicious bile duct stones who were not diagnosed by CT scan.
Tuberculosis in the news: How do Portuguese media cover TB
Authors: F. Lopes, R. Duarte, G.B. Migliori, R. Araújo
Journal: Pulmonology (2018)

From a public health perspective, media can influence public perceptions towards the severity of an illness, the risks of becoming ill, change seek-care behaviours or reduce disease related stigma. With the aim analysing the media coverage of tuberculosis in the Portuguese press, we analyzed all news texts published between 2012 and 2014 in six National newspapers (Expresso, Público and Diário de Notícias – broadsheets; Sol, Jornal de Notícias and Correio da Manhã – tabloids). Our corpus was composed of 10,736 news pieces and 23,495 news sources. We then conducted a quantitative analysis based on descriptive statistics, through the data analysis software SPSS. Tumours, HIV-Aids, Influenza, Transplants, Hepatitis, Obesity, Dengue, Mental Disorders and Heart Diseases were the most media covered pathologies, ahead of tuberculosis. Tumours represented 22% of all news, tuberculosis only represented 1.9% – there is a noteworthy difference among media treatment. When it comes to the news themes, Tuberculosis was mainly news due to alarm and risk situations (53.4% of all texts). This also means that stories were usually negative, which may lead to a stigmatization of this disease. Even though the numbers were not very expressive, there was some media attention thrown at prevention. Media intervention is a fundamental public health tool that could be more developed – it would be important to understand what are the interventions with higher impact on health and how to better use them.
Impact of processing technique on bronchoalveolar lavage cellular analysis
Authors: Leila Barss, Kristin L. Fraser, Margaret M. Kelly, Kerri A. Johannson
Journal: European Respiratory Journal (2018)

We read with great interest the study by Bollmann et al . [1] wherein the authors describe the impact of collection protocols and bronchoscope lumen size on bronchoalveolar lavage fluid (BALF) cellular analysis. Their findings highlight the importance of standardising BALF collection protocols in order to meaningfully interpret and compare BALF analysis results, for both clinical and research purposes. As a complement to their study, we would like to emphasise the importance of laboratory methods used to process the collected sample. We present our experience with highly discordant BALF cell counts and differentials, using two processing protocols in our local laboratory. BALF cellular analysis results are greatly impacted by processing technique #AdvancesinILD @ERSTalk <http://ow.ly/u9js30i1dUP>
Effect of chimeric antigen receptor (CAR) T cells on clonal expansion of endogenous non-CAR T cells in patients (pts) with advanced solid cancer.
Authors: Rebecca H Kim, Gabriela Plesa, Whitney Gladney, Irina Kulikovskaya, Bruce L Levine, Simon F. Lacey, Carl H. June, Jan J. Melenhorst, Gregory Lawrence Beatty
Journal: Journal of Clinical Oncology (2017)

3011 Background: CAR T cells have produced remarkable responses in heme malignancies, but efficacy in solid cancers is limited. Poor in vivo persistence and heterogeneous expression of the CAR target on tumors are potential barriers to the success of CAR T cell therapy. However, even with transient persistence, CAR T cells may elicit a “vaccine” effect by inducing cancer cell death and subsequent release of tumor antigens that could stimulate tumor-specific T cell activity. Methods: 6 pts with pancreatic ductal adenocarcinoma (PDAC) received repeated 3x per week intravenous (iv) infusions of mRNA-transfected mesothelin-redirected CAR T cells (CARTmeso). Pts with PDAC (n = 5), ovarian carcinoma (n = 5), and mesothelioma (n = 5) received iv infusion of lentiviral-transduced (lenti) CARTmeso with or without cyclophosphamide (Cy) preconditioning. Peripheral blood samples were collected from pts at baseline and defined time points after treatment. Genomic DNA from these samples or from pre-infused CAR T cell product was used for deep sequencing of the TCRbeta chain using the ImmunoSEQ platform. A TCRbeta clone was considered to have expanded from baseline to defined time points after treatment if it showed a two-fold change from baseline and met statistical significance by Fisher’s exact test (p &lt; 0.05). Results: mRNA CARTmeso cells persisted in vivo for &lt; 24 hrs. Unexpectedly, therapy induced clonal T cell expansion detected in the blood by day 14 in all 6 pts. Expanded clones underwent contraction by day 28 in 3 pts. In one pt, peripherally expanded clones were also detected in a tumor biopsy, but without significant intratumoral clonal expansion. Lenti CARTmeso therapy also induced peripheral expansion of T cell clones both present and not present in the infused CAR T cell product. However, with Cy preconditioning, clonal expansion seen after lenti CARTmeso therapy was predominately restricted to clones detected in the CAR T cell product. Conclusions: In pts with advanced solid cancers, CARTmeso stimulates clonal expansion of endogenous T cells, which is lost with Cy conditioning. Findings suggest that CAR T cells may elicit a “vaccine” effect with potential therapeutic implications.
SAFETY AND EFFICACY OF HYBRID-APC FOR THE TREATMENT OF REFRACTORY GAVE
Authors: OV Hernández Mondragón, LA Lopez Valenzuela, JM Blancas Valencia, D Espinosa Saavedra, G Blanco Velasco
Journal: Endoscopy (2018)

We present the case of a 62 years-old female refered to our hospital because of melena and iron deficiency anemia. Her past medical history included type 2 Diabetes and arterial hypertension in good control. She begun her complaint in 2013 with diagnosis of Gastric Antral Vascular Ectasia and received endoscopic treatment since then with argon plasma coagulation, with partial response. In 4 years she had requiered 12 hospitalizations and 38 transfusions combined with iron IV applications. However, and because of being a refractory case the new hybrid-APC management was offered.
ENDOCUFF® ASSISTED COLONOSCOPY VERSUS STANDARD COLONOSCOPY IN THE SURVEILLANCE OF THE SERRATED POLYPOSIS SYNDROME. A RANDOMIZED, CONTROLLED AND MULTICENTER TRIAL
Authors: L Rivero-Sánchez, J López Vicente, L Hernandez Villalba, I Puig, C Arnau, L Moreno, M Díaz, C Rodriguez de Miguel, T Ocaña, L Moreira, M Cuatrecasas, S Carballal, A Sánchez, J Llach, F Balaguer, M Pellisé
Journal: Endoscopy (2018)

Patients with serrated polyposis syndrome (SPS) have an increased risk of colorectal cancer (CRC). This risk decreases during annual endoscopic surveillance. Endocuff® (Arc-Medical-Design, Leeds, UK) is a cap with plastic projections that flatten the colonic folds during removal, improving the visualization of the mucosal surface and detection of lesions. We aimed to evaluate if the Endocuff Assisted Colonoscopy (ECC) improves the detection of the serrated lesions (SL) in the surveillance of patients with SPS in relation to the Standard Colonoscopy (SC).
Trastuzumab-Induced Early Cardiac Dysfunction Assessed by Speckle Tracking Echocardiography: Correlation with Chronic Inflammation and Oxidative Stress Markers
Authors: M. Dessi', G. Mantovani, C. Madeddu, L. Orgiano, P. Alessandra, C. Cadeddu, G. Antoni, R. Serpe, G. Mercuro
Journal: Annals of Oncology (2012)
Résultats carcinologiques à long terme de la séquence stent-colectomie versus chirurgie en 2 temps dans le traitement curatif des occlusions tumorales du côlon gauche
Authors: F Browet, D Fuks, C Sabbagh, F Dumont, E Bartoli, T Yzet, F de Dominicis, R Delcenserie, F Brazier, JL Dupas, P Verhaeghe, JM Regimbeau
Journal: Endoscopy (2009)

Introduction: Le stent colique a montré un intérêt dans les cancers du côlon gauche en occlusion (CCGO). Le but de ce travail était de comparer les résultats carcinologiques des patients pris en charge à visée curative pour CCGO avec ou sans stent.
ACUTE COLONIC OBSTRUCTION CAUSED BY LEFT COLO-RECTAL CANCER. FACTORS RELATED TO MORTALITY AND RECURRENCE
Authors: I Couto-Worner, A Guerrero-Montañés, M López-Álvarez, L Yáñez-González-Dopeso, S Pita-Fernández, P Alonso-Aguirre
Journal: Endoscopy (2018)

To evaluate factors involved in mortality and recurrence in patients who presented an acute colonic obstruction secondary to left colon cancer.
THE IMPACT OF ENDOSCOPIC EVALUATION PRIOR TO BARIATRIC SURGERY
Authors: C Arieira, F Dias de Castro, P Boal Carvalho, J Cotter
Journal: Endoscopy (2018)

Bariatric surgery (BS) is one of the most effective approaches to weight loss. Performing esophagogastroduodenoscopy (EGD) prior to BS is controversial, but allows the detection and treatment of mucosal lesions that may affect surgical decision and type of surgery.
Bilateral striatal necrosis and dyschromatosis symmetrica hereditaria: A-I editing efficiency of <i>ADAR1</i> mutants and phenotype expression
Authors: M. Kono, M. Suganuma, A. Dutta, S.K. Ghosh, T. Takeichi, Y. Muro, M. Akiyama
Journal: British Journal of Dermatology (2018)
ENDOSCOPIC ULTRASOUND-GUIDED ETHANOL ABLATION THERAPY FOR SOLID PANCREATIC TUMORS
Authors: WH Paik, JH Choi, MS You, BS Shin, YH Choi, J Kang, SH Lee, JK Ryu, YT Kim
Journal: Endoscopy (2018)

Endoscopic ultrasound-guided ethanol ablation (EUS-EA) is recently introduced for the treatment of pancreatic solid tumors. However, the effect and safeness of this treatment have not been well investigated yet. The aim of this study was to determine the feasibility, effect and complications of EUS-EA for pancreatic solid lesions.
Mentoring in the Era of #MeToo
Authors: Julie Story Byerley
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P265: Cancer Risk in Persons After a Diagnosis of Clinical Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study
Authors: Yejin Mok, Roberta Florido, Elizabeth Selvin, Anna Prizment, Corinne E Joshu, Elizabeth A Platz, Kunihiro Matsushita
Journal: Circulation (2018)

Introduction: With improved survival of patients with cardiovascular disease (CVD), the risks of non-CVD outcomes is of increasing interest. We investigated the risk of subsequent cancer in persons with clinical CVD compared to those without using a matched cohort study nested in the ARIC study. Hypothesis: Persons with CVD may have higher risk of cancer compared to those without. Methods: In ARIC participants (aged 45-64 years) without prevalent CVD or cancer at the study baseline (1987-1989), we first identified every participant who developed clinical CVD (myocardial infarction [MI], heart failure, or stroke as a combined outcome and separately) during follow-up (through 2012). For each of them, applying incidence density sampling, we selected up to two participants without clinical CVD matched on key confounders (age, sex, race, diabetes, hypertension, lipid-lowering therapy, and smoking). Then, we used the Cox proportional hazards regression to estimate the risk of total and site-specific cancer comparing CVD to no CVD further adjusting for conventional risk factors for CVD or cancer, socioeconomic status, insurance, and routine physical examination. Results: We followed 2,565 with CVD and 4,622 without CVD from the date of sampling for a total of 62,772 person-years (mean of 9 years). The hazard ratio [HR] for total cancer risk was 1.13 (95% confidence interval, 1.00-1.32) for participants with CVD compared to those without. None of the HRs for site-specific cancers were statistically significant. When individual CVD subtypes were analyzed separately, participants with MI and heart failure had 2.1- and 1.3- folds significantly higher risk of total cancer compared to those without, respectively. Participants with MI had significantly increased HR in major types of cancer such as prostate, lung, and breast, with adjusted HR ranging from 2.5 to 3.5. Conclusion: Persons with clinical CVD, especially MI, had a modestly increased risk of total cancer following that event compared to those without. Future studies are warranted to better understand its potential reasons.
Endoscopic submucosal dissection with sentinel node navigation surgery for early gastric cancer
Authors: G. Bok, Y. Kim, S. Jin, C. Chun, T. Lee, H. Kim, S. Jeon, J. Cho
Journal: Endoscopy (2012)

We combined endoscopic submucosal dissection (ESD) and sentinel node navigation surgery with the purpose of achieving complete resection of early gastric cancer while preserving the organ and assessing pathological nodal status. A total of 13 patients with cT1( ≤ 3 cm)N0 early gastric cancer underwent combined ESD and sentinel node navigation surgery (ESN) at a single tertiary referral center. Sentinel node navigation surgery using indocyanine green was performed during ESD and all suspected sentinel nodes were removed laparoscopically and examined intraoperatively. ESN was converted to gastrectomy with D2 dissection if there was evidence of metastasis on frozen section. ESN was completed in 12 patients and in 1 patient was converted to gastrectomy after sentinel node navigation surgery. En bloc tumor resection was achieved in all cases. Two patients underwent additional gastrectomy because they had tumor-positive vertical margins. In all cases ESN was conducted without intraoperative or postoperative adverse events. ESN is a feasible minimally invasive procedure that allows en bloc tumor resection to be achieved while assessing the pathological status of the lymph nodes.
Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification
Authors: Yutaka Kurebayashi, Hidenori Ojima, Hanako Tsujikawa, Naoto Kubota, Junki Maehara, Yuta Abe, Minoru Kitago, Masahiro Shinoda, Yuko Kitagawa, Michiie Sakamoto
Journal: Hepatology (2018)

Immune cells constitute an important element of tumor tissue. Accumulating evidence indicates their clinicopathological significance in predicting prognosis and therapeutic efficacy. Nonetheless, the combinations of immune cells forming the immune microenvironment and their association with histological findings remain largely unknown. Moreover, it is unclear which immune cells or immune microenvironments are the most prognostically significant. Here, we comprehensively analyzed the immune microenvironment and its intratumor heterogeneity in 919 regions of 158 hepatocellular carcinomas (HCCs), and the results were compared with the corresponding histological and prognostic data. Consequently, we classified the immune microenvironment of HCC into three distinct immunosubtypes: Immune‐high, Immune‐mid, and Immune‐low. The Immune‐high subtype was characterized by increased B‐/plasma‐cell and T cell infiltration, and the Immune‐high subtype and B‐cell infiltration were identified as independent positive prognostic factors. Varying degrees of intratumor heterogeneity of the immune microenvironment were observed, some of which reflected the multistep nature of HCC carcinogenesis. However, the predominant pattern of immunosubtype and immune cell infiltration of each tumor was prognostically important. Of note, the Immune‐high subtype was associated with poorly differentiated HCC, cytokeratin 19 (CK19) + , and/or Sal‐like protein 4 (SALL4) + high‐grade HCC, and Hoshida's S1/Boyault's G2 subclasses. Furthermore, patients with high‐grade HCC of the predominant Immune‐high subtype had significantly better prognosis. These results provide a rationale for evaluating the immune microenvironment in addition to the usual histological/molecular classification of HCC. Conclusion : The immune microenvironment of HCC can be classified into three immunosubtypes (Immune‐high, Immune‐mid, and Immune‐low) with additional prognostic impact on histological and molecular classification of HCC. (H epatology 2018)
Etude comparative des differents types des dissecteurs à jet d eau
Authors: JC Letard, F Cessot, JM Canard, B Kieffer, P Capot, PC Charles, D Sautereau
Journal: Endoscopy (2009)

Introduction: La dissection sous muqueuse (ESD) s'est développée depuis 2000, avec deux types de dissecteurs à injection d'eau sous pression: le Flush Knife (FN) injecteur/dissecteur à pointe courte; et l'injecteur Erbe Jet 1 (EJ1) utilisé en alternance avec un dissecteur conventionnel. Le but de ce travail était de comparer ces deux systèmes.
Endoscopic Lithotripsy in the Common Bile Duct
Authors: H. Koch, M. Stolte, V. Walz
Journal: Endoscopy (1977)

After appropriate preliminary experiments in animals and in corpses, electrohydraulic lithotripsy has been used for the first time in humans in an attempt to destroy stones in the bile duct. For this purpose, a lithotripsy probe combined with a Dormia basket was constructed. To date, this method has been successfully applied to break fragments off large calculi in three patients, without any complications arising. In one case, subsequent extraction of the remaining part of the stone was possible. The probe must, however, be improved to ensure that the stone is always held centrally in the basket.
The Verge of Collapse
Authors: Matthew Weinstock, Anand Vaidya, Souheil El-Chemaly, John Godleski, Elizabeth Henske
Journal: New England Journal of Medicine (2018)

A 43-year-old woman with an unremarkable medical history presented to her primary care physician with chest pain, cough, and dyspnea that had developed during the preceding 2 weeks. The pain was localized to the right side of her chest, did not radiate, and worsened with inspiration. The cough was not productive of sputum. The patient noted that the dyspnea . . .
QUALITY ASSESSMENT OF IN-PATIENT COLONOSCOPIES – HOW CAN WE IMPROVE?
Authors: O Spence, E Coster, M Thoufeeq
Journal: Endoscopy (2018)

Adequate bowel preparation is essential for effective examination of the colon at colonoscopy. Here, we looked at the quality of cleansing, limitations, risks and benefits of in-patient colonoscopies (IPC).
THE ROLE OF WATER EXCHANGE IN UNSEDATED COLONOSCOPY – A RANDOMIZED COMPARATIVE STUDY
Authors: R Azevedo, C Leitão, F Pereira, H Ribeiro, J Pinto, A Caldeira, R Sousa, A Banhudo
Journal: Endoscopy (2018)

Unsedated colonoscopy can be painful, poorly tolerated by patients and associated with unsatisfactory technical performance. Previous studies report an advantage of water exchange over conventional air insufflation in reducing pain during unsedated colonoscopy. Our goal was to analyze the impact of water exchange colonoscopy in the maximum level of pain reported by patients submitted to unsedated colonoscopy, compared to conventional air insufflation.