tbuckley/cabot-search huggingface dataset:
Pneumonic plague outbreak hits cities in Madagascar
Authors: Zosia Kmietowicz
Journal: BMJ (2017)

Ten cities in Madagascar have been hit by pneumonic plague, the first time the most virulent form of the disease has been seen in densely populated urban areas, the World Health Organization has said.

Although plague is endemic to Madagascar, bubonic plague predominates, generally affecting remote areas of the country. But the government confirmed on 30 September that a 31 year old basketball coach from the Seychelles who was taking part in a basketball …
Tackling concussion in professional rugby union: a case–control study of tackle-based risk factors and recommendations for primary prevention
Authors: Matthew J Cross, Ross Tucker, Martin Raftery, Ben Hester, Sean Williams, Keith A Stokes, Craig Ranson, Prav Mathema, Simon Kemp
Journal: British Journal of Sports Medicine (2017)

Concussion, the most common injury in professional rugby union, occurs most commonly during the tackle. Thus, we investigated the association between tackle characteristics and concussion.182 video clips of tackles leading to clinically diagnosed concussion and 4619 tackles that did not were coded across three professional rugby union competitions. A variable selection process was undertaken to identify the most important variables for interpretation. A multivariate generalised linear model was used to model the association between retained variables and concussion risk. Magnitude-based inferences provided an interpretation of the real-world relevance of the outcomes.The four retained variables were: accelerating player, tackler speed, head contact type and tackle type. Overall, 70% of concussions occurred to the tackler and 30% to the ball carrier. There was a higher risk of concussion if the tackler accelerated into the tackle (OR: 2.49, 95% CI 1.70 to 3.64) or the tackler was moving at high speed (OR: 2.64, 95% CI 1.92 to 3.63). Head contact with the opposing player's head (OR: 39.9, 95% CI 22.2 to 71.1) resulted in a substantially greater risk of concussion compared with all other head contact locations.Interventions that reduce the speed and acceleration of the tackler and reduce exposure to head-to-head contact would likely reduce concussion risk in professional rugby union.
Inter-test reproducibility of the lung clearance index measured by multiple breath washout
Authors: Esther Oude Engberink, Felix Ratjen, Stephanie D. Davis, George Retsch-Bogart, Reshma Amin, Sanja Stanojevic
Journal: European Respiratory Journal (2017)

The lung clearance index (LCI) has strong intra-test repeatability; however, the inter-test reproducibility of the LCI is poorly defined. The aim of the present study was to define a physiologically meaningful change in LCI in preschool children, which discriminates changes associated with disease progression from biological variability. Repeated LCI measurements from a longitudinal cohort study of children with cystic fibrosis and age-matched controls were collected to define the inter-visit reproducibility of the LCI. Absolute change, the coefficient of variation, Bland–Altman limits of agreement, the coefficient of repeatability, intra-class correlation coefficient, and percentage changes were calculated. LCI measurements (n=505) from 71 healthy and 77 cystic fibrosis participants (aged 2.6–6 years) were analysed. LCI variability was proportional to its magnitude, such that reproducibility defined by absolute changes is biased. A physiologically relevant change for quarterly LCI measurements in health was defined as exceeding ±15%. In clinically stable cystic fibrosis participants, the threshold was higher (±25%); however, for measurements made 24 h apart, the threshold was similar to that observed in health (±17%). A percentage change in LCI greater than ±15% in preschool children can be considered physiologically relevant and greater than the biological variability of the test.
Authors reply: Q fever in the Netherlands – what matters is seriousness of disease rather than quantity
Authors: B Schimmer, G Morroy, F Dijkstra, P M Schneeberger, G Weers-Pothoff, A Timen, C Wijkmans, W van der Hoek
Journal: Eurosurveillance (2008)

Preview this article: Authors reply: Q fever in the Netherlands – what matters is seriousness of disease rather than quantity, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/13/37/art18976-en-1.gif
BRCA1&amp;2 tumoral and germline status for ovarian cancer patients in first line setting within the PAOLA-01 trial
Authors: C. Callens, D. Vaur, I. Soubeyran, E. Rouleau, P-A. Just, E. Guillerm, L. Golmard, N. Goardon, N. Sevenet, O. Cabaret, P. Harter, A. Gonzalez Martin, K. Fujiwara, S. Pignata, N. Colombo, C. Marth, I. Vergote, J. Mäenpää, E. Pujade-Lauraine, I. Ray-Coquard
Journal: Annals of Oncology (2017)
Vigilância da tuberculose na região Europeia da OMS, 1995-1996
Authors: D Antoine, V Schwoebel, J Veen, M. C. Raviglione, H. L. Rieder
Journal: Eurosurveillance (1998)

O programa EuroTB para a vigilância da tuberculose na Europa foi estabelecido em 1996 para colher, analisar, e disseminar dados sobre casos de tuberculose notificados na Regiao Europeia da Organizacao Mundial de Saude (OMS). Depois de um estudo de viabilidade em 1996-1997 sobre os casos notificados em 1995 (1), implementou-se uma rotina de recolha de dados. O programa e coordenado conjuntamente pelo Centro Europeu de Monitorizacao Epidemiologica do SIDA, Saint Maurice, Franca, o Royal Netherlands Tuberculosis Association, Haia, Holanda e a Unidade de Vigilância, Epidemiologia e de Saude Respiratoria, Programa Global de Tuberculose, OMS, Genebra, Suica e a Uniao Internacional Contra a Tuberculose e Doencas Pulmonares, Paris, Franca.
Factors associated with prolonged time to treatment failure with fulvestrant 500 mg in patients with postmenopausal estrogen receptor-positive advanced/metastatic breast cancer (JBCRG-C06; Safari): A subgroup analysis
Authors: H. Kawaguchi, K. Aogi, N. Masuda, T. Nakayama, Y. Ito, S. Ohtani, N. Sato, T. Takano, S. Saji, E. Tokunaga, Y. Hasegawa, M. Hattori, T. Fujisawa, S. Morita, H. Yamashita, T. Yamashita, Y. Yamamoto, D. Yotsumoto, M. Toi, S. Ohno
Journal: Annals of Oncology (2017)
Phase 1b/2 Study (SCORES) assessing safety, tolerability, and preliminary anti-tumor activity of durvalumab plus AZD9150 or AZD5069 in patients with advanced solid malignancies and squamous cell carcinoma of the head and neck (SCCHN)
Authors: E.E. Cohen, D.S. Hong, T. Wise Draper, W. Nassib William, D. Schrijvers, R. Mesia Nin, M.L. Scott, P. Lyne, G. Mugundu, P. McCoon, C.E. Cook, M.M. Mehta, U. Keilholz
Journal: Annals of Oncology (2017)
Tamoxifen versus anastrozole as primary endocrine therapy in older women with early operable primary breast cancer.
Authors: Binafsha Manzoor Syed, Dal Morgan, Ian O. Ellis, Kwok-Leung Cheung
Journal: Journal of Clinical Oncology (2014)

e11533 Background: Aromatase inhibitors (AIs) have shown superiority over tamoxifen in metastatic, neoadjuvant (for locally advanced disease) andadjuvant settings in postmenopausal women with oestrogen receptor positive (ER+) breast cancer. However evidence is scarce in the context of primary endocrine therapy in older women, especially when most of their ER+tumours are known to be very ER-rich (with a high histochemical (H) score). This study aimed to compare the efficacy between these two treatments in such setting. Methods: Between 1973-2010, 558 older (≥70 years) women with ER+ (H-score≥50) early operable primary (T1-2,N0-1,M0) invasive breast carcinomareceived primary endocrine therapy as they refused or were unfit for surgery. Tamoxifen(n=434) was given as the agent of choice while anastrozole(n=114), following its introduction in 1990s, was prescribed in cases of contraindications (eg endometrial or thromboembolic). All patients were followed up in a dedicated combined surgical/oncology clinic with response monitored according to UICC criteria. Results: At a median follow-up of 39 months (longest = 207), when compared to those on tamoxifen, patients receiving anastrozole had significantly longer mediantime to progression (60versus 48 months, p=0.02), and better 5-year progression-free survival (50% versus 40%, p=0.02) and eventual best response (complete response = 42.4% versus 28.6%, p=0.02)rates.There was no significant difference in clinical benefit rates at 6 months, duration of clinical benefit, overall or breast cancer specific survival rates between them. Conclusions: Anastrozole, the most established third-generation AI, has been shown in this large series to produce significantly better long-term efficacy over tamoxifen, when being used as the sole therapy in older women with ER-rich early operable primary breast cancer. This provides the evidence base for using it as the agent of choice in this context.
Due epidemie di parotite in bambini vaccinati con il ceppo Rubini indicano una bassa efficacia vaccinale
Authors: C Pons, T Pelayo, I Pachon, A Galmes, L González, C Sánchez, F Martinez
Journal: Eurosurveillance (2000)

Il presente articolo riporta uno studio descrittivo su due epidemie di orecchioni in citta della Spagna nel 1998 ed una valutazione dell'efficacia del vaccino utilizzato. Fornisce le prove del basso livello di protezione contro il virus della parotite, come e gia stato osservato precedentemente in soggetti vaccinati con il ceppo Rubini.
Clinical utility of in depth RNA sequencing for non-metastatic triple negative breast cancers.
Authors: Benoit Thouvenot, Stephane Verdun, Julie Tomasina, Benoit Hilselberger, Marie Brulliard, Lionel Bonnard, Marina Trarbach, Virginie Ogier, Bernard Emile Bihain
Journal: Journal of Clinical Oncology (2015)

1088 Background: Triple negative breast cancers (TNBC), that represent the most severe form of the disease, are not amenable to current targeted therapies. RNA DNA divergences (RDD) reflect changes in RNA sequences not present at the DNA level. Methods: DNA and RNA from fresh frozen samples collected from 65 patients diagnosed with non metastatic TNBC before the age of 65 Y were sequenced with Illumina. The cohort was divided in a training set (n = 20) -9 alive after 2500 days of follow up and 11 dead within 1000 days following diagnosis- and a blind replication set (n = 45). Results: On the training set, sparse PLS discriminant analysis identified 5 transcripts with statistically significant different RDD rate that, when combined, separated patients with good and poor outcome with greater than 90 % accuracy after cross validation. Kaplan-Meier analysis showed that application of the RDD based algorithm to 45 unknown samples was highly predictive of clinical outcome (p < 10-4). Most importantly, RDD algorithm accurately predicted outcome of patients with in situ, stage I and II TNBC (n = 53), 36 were predicted with good outcome and all are alive at the last follow-up irrespective of chemotherapy (n = 10 received no post-surgery treatment). RDD algorithm performances were not affected by patients ethnic origin, recruitment centers (n = 11), BRAC mutation, nor menopausal status. Neither positive lymph node (p = 0.09), nor tumor size (p = 0.89), nor Ki67 (p = 0.84), nor an expression-based model (p = 0.82) were statistically significant predictors of TNBC clinical outcome. Conclusions: RDD are previously unsuspected molecular events strongly associated with TNBC severity. The most immediate clinical application of the finding is to eliminate the need for conventional and potentially harmful chemotherapy for patients with predicted good outcome. Patients included in the current analysis were mostly from the USA. Therefore, a larger retrospective study based on an european cohort (Patients and Methods of the PATH Biobank – A Resource for Breast Cancer research; Waldmann A et al. Geburtshilfe Frauenheilkd. 2014 Apr;74(4):361-369) and powered to statistically ascertain the accuracy of the test, is currently undergoing in depth RNA sequencing.
Patrones de la infección por el virus Puumala en Finlandia
Authors: Angie Rose, O Vapalahti, O Lyytikäinen, P Nuorti
Journal: Eurosurveillance (2003)

La infeccion por el hantavirus Puumala es prevalente en casi toda Europa, y en las zonas endemicas puede ser la causa mas comun de insuficiencia renal aguda. Para evaluar las tendencias de la incidencia de infecciones por virus Puumala en Finlandia, hemos analizado los datos de vigilancia nacionales durante periodos de doce meses desde marzo de 1995 a febrero de 2002. Durante este tiempo, 8.184 casos confirmados microbiologicamente fueron declarados al Registro Nacional de Enfermedades Infecciosas. Se identificaron tres periodos epidemicos, cuyo numero de casos fue superior a 1.400 (aproximadamente 600-900 casos por periodo no epidemico). La incidencia de la infeccion por hantavirus Puumala vario segun la region geografica durante el periodo del estudio, y el numero global de casos puede seguir aumentando.
Outcomes of prechemotherapy (pCRx) abiraterone acetate (AA) or enzalutamide (E) for metastatic castration-resistant prostate cancer (mCRPC) after ADT + Docetaxel (D) or ADT alone for metastatic hormone sensitive prostate cancer (mHSPC) in a multi-institution hospital-based registry
Authors: E. Francini, S. Yip, N.S. Ahmed, H. Li, L. Ardolino, C.P. Evan, M. Kaymakcalan, G.K. Shaw, P. Kantoff, M.E. Taplin, N. Alimohamed, A.M. Joshua, D.Y.C. Heng, C.J. Sweeney
Journal: Annals of Oncology (2017)
Potential Bioeffects of Ultrasonic Destruction of Microbubble Contrast Agents⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Ralph V. Shohet, Paul A. Grayburn
Journal: Journal of the American College of Cardiology (2006)
Randomized results of fixed-duration (1-yr) vs continuous nivolumab in patients (pts) with advanced non-small cell lung cancer (NSCLC)
Authors: D.R. Spigel, M. McLeod, M.A. Hussein, D.M. Waterhouse, L. Einhorn, L. Horn, B. Creelan, S. Babu, N.B. Leighl, F. Couture, J. Chandler, G. Goss, G. Keogh, E.B. Garon, K.B. Blankstein, D.B. Daniel, M. Mohamed, A. Li, N. Aanur, R. Jotte
Journal: Annals of Oncology (2017)
GW28-e0457 Hypoxia-induced Jagged1 expression in cardiomyocytes: role in the differentiation of c-Kit+ cardiac stem cells
Authors: Keke Wang, Ranran Ding, Yanping Ha, Zhenliang Wang, Yanan Jia, Rujia Li, Zhihua Shen, Junli Guo, Wei Jie
Journal: Journal of the American College of Cardiology (2017)
Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy
Authors: Florian Eichler, Christine Duncan, Patricia L. Musolino, Paul J. Orchard, Satiro De Oliveira, Adrian J. Thrasher, Myriam Armant, Colleen Dansereau, Troy C. Lund, Weston P. Miller, Gerald V. Raymond, Raman Sankar, Ami J. Shah, Caroline Sevin, H. Bobby Gaspar, Paul Gissen, Hernan Amartino, Drago Bratkovic, Nicholas J.C. Smith, Asif M. Paker, Esther Shamir, Tara O’Meara, David Davidson, Patrick Aubourg, David A. Williams
Journal: New England Journal of Medicine (2017)

In X-linked adrenoleukodystrophy, mutations in ABCD1 lead to loss of function of the ALD protein. Cerebral adrenoleukodystrophy is characterized by demyelination and neurodegeneration. Disease progression, which leads to loss of neurologic function and death, can be halted only with allogeneic hematopoietic stem-cell transplantation.We enrolled boys with cerebral adrenoleukodystrophy in a single-group, open-label, phase 2-3 safety and efficacy study. Patients were required to have early-stage disease and gadolinium enhancement on magnetic resonance imaging (MRI) at screening. The investigational therapy involved infusion of autologous CD34+ cells transduced with the elivaldogene tavalentivec (Lenti-D) lentiviral vector. In this interim analysis, patients were assessed for the occurrence of graft-versus-host disease, death, and major functional disabilities, as well as changes in neurologic function and in the extent of lesions on MRI. The primary end point was being alive and having no major functional disability at 24 months after infusion.A total of 17 boys received Lenti-D gene therapy. At the time of the interim analysis, the median follow-up was 29.4 months (range, 21.6 to 42.0). All the patients had gene-marked cells after engraftment, with no evidence of preferential integration near known oncogenes or clonal outgrowth. Measurable ALD protein was observed in all the patients. No treatment-related death or graft-versus-host disease had been reported; 15 of the 17 patients (88%) were alive and free of major functional disability, with minimal clinical symptoms. One patient, who had had rapid neurologic deterioration, had died from disease progression. Another patient, who had had evidence of disease progression on MRI, had withdrawn from the study to undergo allogeneic stem-cell transplantation and later died from transplantation-related complications.Early results of this study suggest that Lenti-D gene therapy may be a safe and effective alternative to allogeneic stem-cell transplantation in boys with early-stage cerebral adrenoleukodystrophy. Additional follow-up is needed to fully assess the duration of response and long-term safety. (Funded by Bluebird Bio and others; STARBEAM ClinicalTrials.gov number, NCT01896102 ; ClinicalTrialsRegister.eu number, 2011-001953-10 .).
NGS and Sanger screening for BRCA1/BRCA2, CHEK2 and TP53 in Argentinian high-risk breast/ovarian cancer families and bioinformatic studies: Initial results
Authors: L. Bruno, P. Jablonski, M. Ozkul, G. Mercado, J. Sendoya, A. Llera, L. Núñez, R. Valdez, D. Mansilla, V. Cólica, P. Kalfayan, C. Ruggiero, M. Reyes, R. Cerretini
Journal: Annals of Oncology (2017)
GW28-e0434 The clinical significance of serum trimethylamine N-oxide (TMAO) level in patients with chronic heart failure
Authors: Dongqi An, Qiong Zhan, Yujia Bai, Xingfu Huang, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu
Journal: Journal of the American College of Cardiology (2017)
Immunité passive contre la rougeole chez les nourrissons : faut-il modifier les calendriers vaccinaux en Europe?
Authors: K Johansen, P L Lopalco
Journal: Eurosurveillance (2007)

L’elimination de la rougeole d’ici a 2010 s'inscrit dans le cadre d’un plan strategique visant la rougeole et l’infection par la rubeole congenitale dans la region Europe de l’Organisation mondiale de la Sante.
Saving Life, Limb, and Eyesight: Assessing the Medical Rules of Eligibility During Armed Conflict
Authors: Michael L. Gross
Journal: The American Journal of Bioethics (2017)

Medical rules of eligibility permit severely injured Iraqi and Afghan nationals to receive care in Coalition medical facilities only if bed space is available and their injuries result directly from Coalition fire. The first rule favors Coalition soldiers over host-nation nationals and contradicts the principle of impartial, needs-based medical care. To justify preferential care for compatriots, wartime medicine invokes associative obligations of care that favor friends, family, and comrades-in-arms. Associative obligations have little place in peacetime medical care but significantly affect wartime medicine. The second rule suggests liability for collateral harm that is unsupported by international law and military ethics. Absent liability, there are pragmatic reasons to offer medical care to injured local civilians if it quells resentment and cements support for Coalition forces. In contrast to peacetime medicine, military necessity and associative obligations outweigh distributive principles based on medical need during war.
Distribution of the PAM50 breast cancer subtypes within each pathology-based group: a combined analysis of 15,339 patients across 29 studies
Authors: J.M. Cejalvo, T. Pascual, A. Fernández-Martínez, B. Adamo, N. Chic, M. Vidal, L. Rodelo, M. Muñoz, A. Prat
Journal: Annals of Oncology (2017)
Notch pathway inhibition with LY3039478 in soft tissue sarcoma (STS) and gastrointestinal stromal tumours (GIST)
Authors: O. Mir, A. Azaro, J.R. Merchan, R. Chugh, J.C. Trent, J. Rodon, U. Ohnmacht, C. Smith, G.J. Oakley III, A. Le Cesne, J.-C. Soria, K. Benhadji, C. Massard
Journal: Annals of Oncology (2017)
Outcomes 7 Years After Infliximab Withdrawal for Patients With Crohn’s Disease in Sustained Remission
Authors: Catherine Reenaers, Jean-Yves Mary, Maria Nachury, Yoram Bouhnik, David Laharie, Matthieu Allez, Mathurin Fumery, Aurélien Amiot, Guillaume Savoye, Romain Altwegg, Martine Devos, Georgia Malamut, Arnaud Bourreille, Bernard Flourie, Philippe Marteau, Lucine Vuitton, Benoît Coffin, Stéphanie Viennot, Jérôme Lambert, Jean-Frédéric Colombel, Edouard Louis
Journal: Clinical Gastroenterology and Hepatology (2017)
DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer
Authors: Shuo Huang, Damiano Fantini, Bradley J. Merrill, Srilata Bagchi, Grace Guzman, Pradip Raychaudhuri
Journal: Cancer Research (2017)

Deregulation of the Wnt/β-catenin signaling pathway drives the development of colorectal cancer, but understanding of this pathway remains incomplete. Here, we report that the damage-specific DNA-binding protein DDB2 is critical for β-catenin-mediated activation of RNF43, which restricts Wnt signaling by removing Wnt receptors from the cell surface. Reduced expression of DDB2 and RNF43 was observed in human hyperplastic colonic foci. DDB2 recruited EZH2 and β-catenin at an upstream site in the Rnf43 gene, enabling functional interaction with distant TCF4/β-catenin-binding sites in the intron of Rnf43 This novel activity of DDB2 was required for RNF43 function as a negative feedback regulator of Wnt signaling. Mice genetically deficient in DDB2 exhibited increased susceptibility to colon tumor development in a manner associated with higher abundance of the Wnt receptor-expressing cells and greater activation of the downstream Wnt pathway. Our results identify DDB2 as both a partner and regulator of Wnt signaling, with an important role in suppressing colon cancer development. Cancer Res; 77(23); 6562-75. ©2017 AACR.
GW28-e0512 Molecular Mechanisms of Qishen Granule attenuating cardiac fibrosis in rats by regulating Smad3 and GSK3β--downstream mediators of TGF-β Signaling pathway
Authors: Zifan Zeng, Kai Xia, Yong Wang, Chun Li, Shihong Jiao, Wei Wang
Journal: Journal of the American College of Cardiology (2017)
The acquired resistance to the combination of the anti-EGFR cetuximab and the MEK-inhibitor refametinib in KRAS mutated colorectal cancer cell lines depends on PI3K-signalling
Authors: P.P. Vitiello, G. Martini, C. Cardone, D. Ciardiello, V. Belli, N. Matrone, T. Troiani, S. Napolitano, V. Sforza, G. Papaccio, V. Desiderio, V. De Falco, E. Giunta, F. Morgillo, M.R. Diadema, P. Vitale, N. Zanaletti, F. Ciardiello, E. Martinelli
Journal: Annals of Oncology (2017)
Phase 1b multi-indication study of the antibody drug conjugate anetumab ravtansine in patients with mesothelin-expressing advanced or recurrent malignancies
Authors: A.A. Adjei, A. Walter, L. Cupit, J. Siegel, A. Holynskyj, B.H. Childs, C. Elbi
Journal: Annals of Oncology (2017)
GW28-e0862 Comparison of Immune Suppression Strategies for Transplantation of human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Postmyocardial Infarcted Nonhuman Primates
Authors: Keyang Zhu, Qiang Wu, Cheng Ni, Peng Zhang, Zhiwei Zhong, Yan Wu, Yingchao Wang, Yinchuan Xu, Minjian Kong, Haifeng Cheng, Fengjiang Zhang, Qi Chen, Yi Li, Yun Jiang, Jianyi Zhang, Huangtian Yang, Xinyang Hu, Jianan Wang
Journal: Journal of the American College of Cardiology (2017)
The inflamed immune phenotype can be induced by systemic treatment in angiogenic colorectal liver metastases in contrast to non-angiogenic liver metastases
Authors: S. Stremitzer, P. Vermeulen, M. Kockx, L. Dirix, S. Graver, S. Scherer, D. Yang, W. Zhang, J. Stift, F. Wrba, T. Gruenberger, H-J. Lenz
Journal: Annals of Oncology (2017)
Survival in advanced oesophagogastric adenocarcinoma (OGA) improves with the use of multiple lines of therapy: Results from an analysis of over 500 patients (pts)
Authors: C. Cafferkey, M. Davidson, E. Goode, D. Hughes, P. Reguera, R. Kalaitzaki, K. Kouvelakis, C. Peckitt, I. Chau, D. Watkins, S. Rao, D. Cunningham, N. Starling
Journal: Annals of Oncology (2017)