tbuckley/cabot-search huggingface dataset:
Abstract B69: Study of superoxide dismutase-2 protein in HPV-mediated cell transformation
Authors: Gabriela Ávila Fernandes Silva, Rafaella Almeida Lima Nunes, Enrique Boccardo, Luisa Lina Villa, Lara Termini
Journal: Clinical Cancer Research (2018)

Abstract Oxidative stress reflects an imbalance in the maintenance of the intracellular redox state resulting in the accumulation of oxidant species that may contribute to tumorigenesis. The superoxide dismutase 2 protein (SOD2) contributes to cell homeostasis by catalyzing the dismutation of superoxide anion radicals in oxygen and hydrogen peroxide, preventing the direct inactivation of biomolecules. SOD2 protein can be induced by the activation of the NF-kB pathway in several cell types following treatment with interleukin 1β (IL-1β) and tumor necrosis factor alpha (TNFα), both proinflammatory cytokines. In addition, previous studies from the group have shown a direct correlation between increased levels of SOD2 protein and severity of uterine cervix lesions. The aim of this study is to elucidate the involvement of SOD2 in the pathogenesis associated with HPV and in the effect of proinflammatory cytokines. Methods: Primary human keratinocytes transduced with HPV16 oncogenes and cervical cancer derived cell lines were treated with the proinflammatory cytokines TNFα, and IL-1beta. The expression of SOD2 protein involved in IL-1 β and TNFα signaling pathways was determined by Western blot and ELISA. Results: Preliminary results suggest the presence of higher levels of SOD2 expression in uterine cervix-derived tumor cell lines when compared to normal primary keratinocytes. Treatment with IL-1β and TNFα induces SOD2 protein accumulation in in the HPV16 positive cervical-derived tumor line, SiHa. On the other hand, no SOD2 induction was observed in the HPV-negative cervical cancer derived cell line C33. Further replications and additional experiments are needed for conclusions. Citation Format: Gabriela Ávila Fernandes Silva, Rafaella Almeida Lima Nunes, Enrique Boccardo, Luisa Lina Villa, Lara Termini. Study of superoxide dismutase-2 protein in HPV-mediated cell transformation [abstract]. In: Proceedings of the AACR International Conference held in cooperation with the Latin American Cooperative Oncology Group (LACOG) on Translational Cancer Medicine; May 4-6, 2017; São Paulo, Brazil. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(1_Suppl):Abstract nr B69.
A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice
Authors: Haixia Yang, Weicang Wang, Kymberleigh A. Romano, Min Gu, Katherine Z. Sanidad, Daeyoung Kim, Jun Yang, Birgitta Schmidt, Dipak Panigrahy, Ruisong Pei, Derek A. Martin, E. Ilker Ozay, Yuxin Wang, Mingyue Song, Bradley W. Bolling, Hang Xiao, Lisa M. Minter, Guang-Yu Yang, Zhenhua Liu, Federico E. Rey, Guodong Zhang
Journal: Science Translational Medicine (2018)

The commonly used antimicrobial compound triclosan increases colonic inflammation and colon cancer in mice.
Abstract 13339: Isolated Minor Electrocardiographic T-wave Abnormalities and Cardiovascular Mortality in Subjects With and Without Hypertension
Authors: Hisako Tsuji, Ichiro Shiojima
Journal: Circulation (2013)

Background:  Isolated minor T-wave abnormalities not accompanied by ST segment abnormalities or findings of left ventricular (LV) hypertrophy are frequently observed in the general population and their prognostic value is less clear as ST segment abnormalities. However, it may depend on presence or absence of hypertension.   Methods:  Associations of cardiovascular mortality with the isolated minor T-wave abnormalities were studied in citizens who received ECG in the health examination of Moriguchi city, Osaka, Japan in 1997, stratified by presence or absence of hypertension. ECGs were read by 3 cardiologists with the judgment of minor or major abnormalities blinded to any clinical information including blood pressure except for age and sex. Subjects with any major abnormalities on the ECG, history of cardiovascular disease, left bundle branch block, intraventricular conduction delay, or non-sinus rhythm were excluded.   Results:  There were 13,297 subjects and 4,301 subjects had hypertension. Mean age was 58± 10 years with 26% of men. The isolated minor T-wave abnormalities were observed in 226 subjects (118 without hypertension, 108 with hypertension) and included 4 of Minnesota Code (MC) 5-2, 45 of MC 5-3, and 177 of MC 5-4. During a mean follow-up of 12.8± 3.4 years, there were 302 cardiovascular deaths. By multivariate proportional hazards regression analyses after adjustment for age, sex, diabetes, smoking, alcohol drinking, and hypercholesterolemia, subjects with the isolated minor T-wave abnormalities had significantly higher cardiovascular mortality compared to those without any ST-T abnormalities or LV hypertrophy in hypertensives (relative risk (RR)=2.53, 95% confidence interval (CI)=1.23-5.19, p=0.0115), whereas they were not significantly associated with cardiovascular mortality in non-hypertensives (RR=1.68, 95%CI=0.41-6.83, p=0.4708).   Conclusions:  Isolated minor T-wave abnormalities predicted cardiovascular mortality in subjects with hypertension, whereas they didn’t in those without hypertension.
Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung
Authors: Meera G. Nair, Yurong Du, Jacqueline G. Perrigoue, Colby Zaph, Justin J. Taylor, Michael Goldschmidt, Gary P. Swain, George D. Yancopoulos, David M. Valenzuela, Andrew Murphy, Margaret Karow, Sean Stevens, Edward J. Pearce, David Artis
Journal: The Journal of Experimental Medicine (2009)
Eliminating Inappropriate Telemetry Monitoring
Authors: Raymond Y. Yeow, Garth W. Strohbehn, Calvin M. Kagan, Christopher M. Petrilli, Jamuna K. Krishnan, Karli Edholm, L. Scott Sussman, Jaime F. Blanck, Remus I. Popa, Amit K. Pahwa
Journal: JAMA Internal Medicine (2018)

In-hospital continuous electrocardiographic monitoring, commonly referred to as telemetry, has allowed for rapid recognition of life-threatening conditions, including complex arrhythmias and myocardial ischemia. However, inappropriate use can lead to unnecessary downstream testing from "false alarms," which in turn affects clinician efficiency and increases health care costs without benefiting patients. For these reasons, the Society of Hospital Medicine's Choosing Wisely campaign recommended use of a protocol-driven discontinuation of telemetry. The American Heart Association (AHA) developed a set of Practice Standards for the appropriate use of telemetry monitoring in 2004, which they updated in 2017. Unfortunately, the AHA Practice Standards have not been widely adopted-with as many as 43% of monitored patients lacking a recommended indication for monitoring. Thus, we created an overview discussing the safety and efficacy of incorporating the AHA Practice Standards and a review of studies highlighting their successful incorporation within patient care workflow. We conclude by outlining an "implementation blueprint" for health system professionals and administrators seeking to change their institution's culture of telemetry use. As the health care landscape continues to shift, enacting high-value initiatives that improve patient safety and efficiency of care will be critical.
Blocking NMDAR Disrupts Spike Timing and Decouples Monkey Prefrontal Circuits: Implications for Activity-Dependent Disconnection in Schizophrenia
Authors: Jennifer L. Zick, Rachael K. Blackman, David A. Crowe, Bagrat Amirikian, Adele L. DeNicola, Theoden I. Netoff, Matthew V. Chafee
Journal: Neuron (2018)
Ivacaftor treatment of cystic fibrosis in children aged 12 to &lt;24 months and with a CFTR gating mutation (ARRIVAL): a phase 3 single-arm study
Authors: Margaret Rosenfeld, Claire E Wainwright, Mark Higgins, Linda T Wang, Charlotte McKee, Daniel Campbell, Simon Tian, Jennifer Schneider, Steve Cunningham, Jane C Davies, Margaret Rosenfeld, Claire E. Wainwright, Mark Higgins, Linda T. Wang, Charlotte McKee, Daniel Campbell, Simon Tian, Jennifer Schneider, Steve Cunningham, Jane C. Davies, William Harris, Peter Mogayzel, Karen McCoy, Carlos Milla, Ronald Rubenstein, Seth Walker, Philip Black, Gregory Montgomery, Susanna McColley, Peter Hiatt, Gregory Sawicki, Michael Rock, Paul Aurora, Felix Ratjen, Anirban Maitra, Andrew Ives, Erol Gaillard, Paul McNalley, Hiranjan Selvadurai, Philip Robinson
Journal: The Lancet Respiratory Medicine (2018)
The ICD‐11 developmental field study of reliability of diagnoses of high‐burden mental disorders: results among adult patients in mental health settings of 13 countries
Authors: Geoffrey M. Reed, Pratap Sharan, Tahilia J. Rebello, Jared W. Keeley, María Elena Medina‐Mora, Oye Gureje, José Luis Ayuso‐Mateos, Shigenobu Kanba, Brigitte Khoury, Cary S. Kogan, Valery N. Krasnov, Mario Maj, Jair de Jesus Mari, Dan J. Stein, Min Zhao, Tsuyoshi Akiyama, Howard F. Andrews, Elson Asevedo, Majda Cheour, Tecelli Domínguez‐Martínez, Joseph El‐Khoury, Andrea Fiorillo, Jean Grenier, Nitin Gupta, Lola Kola, Maya Kulygina, Itziar Leal‐Leturia, Mario Luciano, Bulumko Lusu, J. Nicolas, I. Martínez‐López, Chihiro Matsumoto, Lucky Umukoro Onofa, Sabrina Paterniti, Shivani Purnima, Rebeca Robles, Manoj K. Sahu, Goodman Sibeko, Na Zhong, Michael B. First, Wolfgang Gaebel, Anne M. Lovell, Toshimasa Maruta, Michael C. Roberts, Kathleen M. Pike
Journal: World Psychiatry (2018)

Reliable, clinically useful, and globally applicable diagnostic classification of mental disorders is an essential foundation for global mental health. The World Health Organization (WHO) is nearing completion of the 11th revision of the International Classification of Diseases and Related Health Problems (ICD‐11). The present study assessed inter‐diagnostician reliability of mental disorders accounting for the greatest proportion of global disease burden and the highest levels of service utilization – schizophrenia and other primary psychotic disorders, mood disorders, anxiety and fear‐related disorders, and disorders specifically associated with stress – among adult patients presenting for treatment at 28 participating centers in 13 countries. A concurrent joint‐rater design was used, focusing specifically on whether two clinicians, relying on the same clinical information, agreed on the diagnosis when separately applying the ICD‐11 diagnostic guidelines. A total of 1,806 patients were assessed by 339 clinicians in the local language. Intraclass kappa coefficients for diagnoses weighted by site and study prevalence ranged from 0.45 (dysthymic disorder) to 0.88 (social anxiety disorder) and would be considered moderate to almost perfect for all diagnoses. Overall, the reliability of the ICD‐11 diagnostic guidelines was superior to that previously reported for equivalent ICD‐10 guidelines. These data provide support for the suitability of the ICD‐11 diagnostic guidelines for implementation at a global level. The findings will inform further revision of the ICD‐11 diagnostic guidelines prior to their publication and the development of programs to support professional training and implementation of the ICD‐11 by WHO member states.
2000년대 초에 유행한 Orientia tsutsugamushi에 의한 간염
Authors: 박재일, 한성희, 조승철, 조용현, 홍상모, 이학현, 윤혜련, 양선영, 윤재훈, 윤영섭, 문지용, 조경란, 백상현, Joo Hyun Sohn, Tae-Hwa Kim, 이동후
Journal: Clinical and Molecular Hepatology (2003)

목적: Orientia tustsugamushi 감염은 삼림에 서식하는 매개충인 진드기(Leptotrombidium)의 유충이 우연히 사람의 피부를 통하여 전파되어 생기는 급성 발열 질환이다. 저자들은 지난 3년 동안 쯔쯔가무시병으로 진단된 환자들에서 간 기능 이상을 확인하고 가을철 간염환자의 감별진단 특히 non-A, non-B, non-C 간염의 진단에 주의를 환기하고자 관찰 결과를 보고하는 바이다. 대상과 방법: 한양대학교 서울병원과 구리병원에 2000년 10월부터 2002년 11월까지 hemagglutinin 법으로 쯔쯔가무시병으로 진단된 환자 22명을 조사 대상으로 삼아 그 진료기록을 조사하였다. 결과: 남년 비는 1:3.4로 여자가 많았다. 연령(범위 31-83세)은 56.4±2.6(평균±표준오차)세였다. 입원시기는 9월 23일부터 11월 15일 사이였고 10월 중순 이후 11월 상순 사이가 제일 많았다. 증상은 발열이 21예로 가장 많았고 근육통 13예, 관절통 12예, 오한 6예, 피부발진 6예 순이었다. 잠복기는 7-9일이 10예로 가장 많았고 13-15일이 4예, 10-12일 3예, 3일 이내 3예, 4-6일 2예였다. ALT(범위 18-345 IU/L)는 93.2±17.3 IU/L(평균±표준오차)였고, AST(범위34-255 IU/L)는 92.5±11.7 IU/L, GGTP (범위 19-251 IU/L)는 132.2±14.5 IU/L로 상승하였지만 혈중 총 빌리루빈은 정상이었다. 모든 환자들은 doxycycline 투여로 호전되었다. 결론: Orientia tsutsugamushi 감염은 대부분, 경도의 간 기능 이상을 동반하므로 특히 가을철 간 기능 이상을 보이는 열성 질환 환자에게서 다른 간 질환과 감별해야 할 질환으로 인지하는 것이 중요하다.
Shortcomings of Research Regarding Long-term Acute Care Hospitals and Skilled Nursing Facilities
Authors: Lane Koenig, John Votto
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Crossing the Iron Gate: Why and How Transferrin Receptors Mediate Viral Entry
Authors: Marianne Wessling-Resnick
Journal: Annual Review of Nutrition (2018)

Because both the host and pathogen require iron, the innate immune response carefully orchestrates control over iron metabolism to limit its availability during times of infection. Nutritional iron deficiency can impair host immunity, while iron overload can cause oxidative stress to propagate harmful viral mutations. An emerging enigma is that many viruses use the primary gatekeeper of iron metabolism, the transferrin receptor, as a means to enter cells. Why and how this iron gate is a viral target for infection are the focus of this review.
Diagnosis of follicular lymphoma from the peripheral blood
Authors: Barbara J. Bain
Journal: American Journal of Hematology (2018)

The bottom left image is from another middle aged man with lymphadenopathy, mild anemia (Hb 128 g/L), a normal platelet count, and a lymphocyte count of 89 × 109/L. The blood film showed small and medium sized lymphocytes with dense chromatin; some were nucleolated and some had deep narrow nuclear clefts. Immunophenotyping showed clonal B cells expressing FMC7 and strong kappa light chain and not expressing CD5 or CD10; follicular lymphoma was confirmed on a lymph node biopsy. The bottom right image is from a young woman with mild splenomegaly, a normal Hb and platelet count, and a lymphocyte count of 11 × 109/L. In addition to some nucleated red blood cells, there were small lymphocytes with similar features to those described in the first two patients. Clonal B cells expressed CD19, CD10, CD79b, FMC7, and strong kappa light chain with CD5 and CD23 being negative. The diagnosis of follicular lymphoma was confirmed on biopsy. The blood film features most suggestive of follicular lymphoma are the presence of small lymphocytes with chromatin that is more uniformly condensed than that of chronic lymphocytic leukemia cells, with some cells showing deep, narrow nuclear clefts and with smear cells not being prominent. Immunophenotyping typically shows expression of pan-B markers with strong surface membrane immunoglobulin and no expression of CD23 or CD200; when there is some degree of pleomorphism, CD5 negativity helps to exclude mantle cell lymphoma and, when it is positive, CD10 expression supports the diagnosis of follicular lymphoma. This diagnosis can be confirmed by fluorescence in situ hybridization on peripheral blood cells, as well as by lymph node biopsy. None.
Psychosocial outcome and health-related quality of life (HRQoL) in advanced melanoma survivors.
Authors: Anne Rogiers, Jennifer De Cremer, Laila Ben Salama, Mark De Ridder, Jan Louis Bernheim, Bart Neyns, Peter Theuns
Journal: Journal of Clinical Oncology (2018)

162 Background: An increasing proportion of advanced melanoma patients (pts), treated with immune checkpoint inhibitors and/or BRAF/MEK-inhibitors, achieve long-term survival. The traumatic experience of melanoma progression, which often involves the brain, puts them at high risk for emotional and neurocognitive function (NCF) disturbances that may negatively impact their HRQoL. Methods: Pts with advanced melanoma (AJCC stages IIIC or IV) who were in remission for at least 1 year after treatment initiation were included in this ongoing single-center therapeutically non-interventional clinical trial. Data on psychosocial outcome and HRQoL were collected using 6 validated questionnaires, a semi-structured psychiatric examination (SSPE) and a computer based neuro-cognitive function (NCF) test. Results: Test results from the first 24 pts (9M/15F; median age 58y (29-87) were analysed. Mean EORTC Global Health Score was significant lower than the European Mean (t[23]=2.713, p= 0.006). The SSPE revealed that all pts reported fear of recurrence; 19 pts (79%) suffered from feelings of insecurity with daily worrying about the disease, associated with a fear of dying. Irritability was a prominent complaint in 18 pts [75%]). Twelve pts (50%) received a message of no hope at diagnosis of metastatic disease which had a persistent major psychological impact. Suicidal ideation occurred in 3 pts (13%), 1 pt (4%) made a suicide attempt (in the absence of depression). Nine pts (38%) reported worrying about their family, 4 pts (17%) had relational problems and 7 pts (29%) had financial problems related to the disease. Despite frequent fatigue complaints, only 4 pts (17%) had mild excessive sleepiness on the Epworth Sleepiness Scale and 9 pts (38%) on the Fatigue Severity Scale. The HADS results indicated a greater occurrence of anxiety compared to depression (N A =10, N D =6). Twenty pts (83%) reported memory complaints, but only 7 pts (29%) had elevated scores on the Cognitive Failure Questionnaire (CFQ). Conclusions: Advanced melanoma survivors are at risk of emotional and neurocognitive disturbances impacting on their HRQoL. Timely detection of psychosocial and neurocognitive problems and adapted care are indicated.
Time to surgery and the impact of delay on triple negative breast cancers and other phenotypes.
Authors: Alina M. Mateo, Anna M. Mazor, Elias Obeid, Elin R. Sigurdson, Lyudmila DeMora, Elizabeth A. Handorf, John M. Daly, Allison A. Aggon, Richard J. Bleicher
Journal: Journal of Clinical Oncology (2018)

e12606 Background: Triple negative (TN) breast cancer has a higher and earlier rate of distant events. It has been suggested that this behavior necessitates earlier surgical intervention for TNs than other breast cancers, and systemic therapy (neoadjuvant chemotherapy [NACT]) if time to surgery is not rapid. This study was performed to determine if preoperative delays more adversely impact TNs than other breast cancer phenotypes. Methods: Women diagnosed from 2004 through 2014 with Stage I - III breast cancers were reviewed from the National Cancer Database (NCDB). Phenotypes were assessed as TN (ER-, PR-, HER2-) hormone receptor positive (HR+) (ER+ and/or PR+, HER2-) and HER2-positive (HER2+) (ER+/-, PR+/-, HER2+). Delays were analyzed continuously as days from diagnosis to surgery and chemotherapy. Quantile regression was used to characterize median delays, and overall survival (OS) was analyzed using Cox proportional hazards models with interactions between delays and phenotype. Results: 351,088 patients met criteria, including 36,505 (10.4%) TNs, 77.9% HR+ and 11.7 % HER2+. Phenotype, among other factors, was predictive of treatment delays. Adjusted median days from diagnosis to surgery and chemotherapy were 29.9, 31.6, and 31.5, (p< 0.0001) and 72.7, 78.0, and 74.4 (p< 0.0001), respectively. Per month of delay to surgery, OS declined for all patients (HR 1.104, p< 0.0001). For chemotherapy recipients, delays per month also lowered OS: diagnosis to surgery (HR 1.085, p< 0.0001); surgery to chemotherapy (HR 1.101, p< 0.0001), with no difference in the effect during these intervals (p= 0.46). In models separating or combining surgery and chemotherapy, adjusting for demographic, tumor, and treatment factors, this survival decline did not vary by breast cancer phenotype (p-values > 0.3). Conclusions: Delays cause small but measurable effects overall, but there are no differences in survival between breast cancer phenotypes from increasing preoperative delay. Our data suggest that urgency between diagnosis and surgery or diagnosis and chemotherapy is not greater for TN breast cancers. Although NACT is advocated to avoid treatment delays, this study does not identify a differential impact of timing on OS.
Cost effectiveness analysis of Oncotype DX testing in patients with synchronous unilateral primary breast cancer.
Authors: Melanie Jean Clark, James Coggan, James J. Dignam, Ruta D. Rao, Lydia Usha, Katherine Kabaker, Mark McCarthy, Eric Finkelstein, Melody A. Cobleigh
Journal: Journal of Clinical Oncology (2018)

e12555 Background: Oncotype DX is a commercial diagnostic test used to predict the likely benefit from chemotherapy in ER+ HER2- node- breast cancer. Patients with multiple, synchronous ipsilateral primary breast cancers often have > 1 tumor tested if results from the first tumor show low or intermediate recurrence scores. The cost effectiveness is unknown. Methods: We reviewed Oncotype Dx results for 43 ER+/HER2- breast cancer patients (37 with the same histology) seen at Rush University Medical Center from 2/2006 to 1/2018 in whom multiple, synchronous, unilateral tumor samples were tested. Results were reported on the numeric risk score and the categorized (low/intermediate/high) recurrence risk. Descriptive statistics examined the risk score distributions and assessed potential correlation between paired samples. A cost effective analysis was performed by calculating the costs of the second test and subsequent treatment and the expected additional QALYs resulting from any treatment deviations. Costs included Oncotype testing of the second tumor and 4 cycles of docetaxel & cyclophosphamide when recommended from results of the second test. Results: The concordance rate for risk category was 79% (34/43 patients) with an increase to 81% (29/36 patients) for tumors of the same histology. Only 1 patient had tumor samples with low and high RS. A gain of an additional life year for this patient was calculated using the UK PREDICT 2.0 tool based on averaged tumor characteristics and age of the 43 patients. The cost of adjuvant therapy with the additional 43 Oncotype tests ($285, 827) divided by an assumed incremental cost benefit ratio of 0.97 years yielded a cost of $294,667 per QALY. Conclusions: Oncotype Dx testing in patients with synchronous, unilateral primary breast cancers generally results in concordant results, especially when of the same histology. Only 1 of 43 patients had discordant low/high tumor scores. When taken into consideration the total cost of testing and adjuvant therapy, a small potential survival benefit, and the $50,000 per QALY standard, testing more than 1 tumor sample on a patient with synchronous, ipsilateral breast cancer is not cost effective.