The Quest to Define Individual Risk After Living Kidney Donation
Authors: Emilio D. Poggio, Peter P. Reese
Journal: Annals of Internal Medicine (2018)

Editorials20 February 2018The Quest to Define Individual Risk After Living Kidney DonationEmilio D. Poggio, MD and Peter P. Reese, MD, MSCEEmilio D. Poggio, MDCleveland Clinic, Cleveland, Ohio (E.D.P.)Search for more papers by this author and Peter P. Reese, MD, MSCEUniversity of Pennsylvania, Philadelphia, Pennsylvania (P.P.R.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M17-3249 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Living-donor kidney transplantation has been a cornerstone treatment for patients with end-stage renal disease (ESRD) since the first living donation in the mid-1950s. In the United States, approximately 140 000 living persons have chosen to donate a kidney since 1988 and their kidneys currently account for about one third of all kidney transplants. Primary care physicians and other internists should have insight into donor outcomes because patients with kidney disease and potential donors may seek their advice. Despite more than 6 decades of living kidney donation, large and high-quality studies of ESRD and other relevant outcomes after donation have been completed ...References1. O'Keeffe LM, Ramond A, Oliver-Williams C, Willeit P, Paige E, Trotter P, et al. Mid- and long-term health risks in living kidney donors. A systematic review and meta-analysis. Ann Intern Med. 2018;168:276-84. doi:10.7326/M17-1235 LinkGoogle Scholar2. Kasiske BL, Anderson-Haag T, Israni AK, Kalil RS, Kimmel PL, Kraus ES, et al. A prospective controlled study of living kidney donors: three-year follow-up. Am J Kidney Dis. 2015;66:114-24. [PMID: 25795073] doi:10.1053/j.ajkd.2015.01.019 CrossrefMedlineGoogle Scholar3. Mjøen G, Hallan S, Hartmann A, Foss A, Midtvedt K, Øyen O, et al. Long-term risks for kidney donors. Kidney Int. 2014;86:162-7. 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Grams ME, Sang Y, Levey AS, Matsushita K, Ballew S, Chang AR, et al; Chronic Kidney Disease Prognosis Consortium. Kidney-failure risk projection for the living kidney-donor candidate. N Engl J Med. 2016;374:411-21. [PMID: 26544982] doi:10.1056/NEJMoa1510491 CrossrefMedlineGoogle Scholar9. Massie AB, Muzaale AD, Luo X, Chow EKH, Locke JE, Nguyen AQ, et al. Quantifying postdonation risk of ESRD in living kidney donors. J Am Soc Nephrol. 2017;28:2749-2755. [PMID: 28450534] doi:10.1681/ASN.2016101084 CrossrefMedlineGoogle Scholar10. Taler SJ, Messersmith EE, Leichtman AB, Gillespie BW, Kew CE, Stegall MD, et al; RELIVE Study Group. Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades. Am J Transplant. 2013;13:390-8. [PMID: 23137211] doi:10.1111/j.1600-6143.2012.04321.x CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Cleveland Clinic, Cleveland, Ohio (E.D.P.)University of Pennsylvania, Philadelphia, Pennsylvania (P.P.R.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-3249.Corresponding Author: Peter P. Reese, MD, MSCE, 917 Blockley Hall, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104; e-mail, peter.[email protected]upenn.edu.Current Author Addresses: Dr. Poggio: Cleveland Clinic, 9500 Euclid Avenue, Desk Q7, Cleveland, OH 44195.Dr. Reese: 917 Blockley Hall, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104.This article was published at Annals.org on 30 January 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMid- and Long-Term Health Risks in Living Kidney Donors Linda M. O'Keeffe , Anna Ramond , Clare Oliver-Williams , Peter Willeit , Ellie Paige , Patrick Trotter , Jonathan Evans , Jonas Wadström , Michael Nicholson , Dave Collett , and Emanuele Di Angelantonio Metrics Cited byRisk Assessment Tools and Innovations in Living Kidney DonationLong-term Mortality Risks Among Living Kidney Donors in Korea 20 February 2018Volume 168, Issue 4Page: 296-297KeywordsDisclosureKidneysNephrectomyPreeclampsiaRelative riskRenal analysisRenal diseasesRenal failureRenal transplantationRisk management ePublished: 30 January 2018 Issue Published: 20 February 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...