CORTICOTROPIN (ACTH) AND THE ADRENAL STEROIDS IN THE MANAGEMENT OF ULCERATIVE COLITIS: OBSERVATIONS IN 240 PATIENTS
Authors: J B KIRSNER, W L PALMER, J A SPENCER, R O BICKS, C F JOHNSON
Journal: Annals of Internal Medicine (1959)

Article1 April 1959CORTICOTROPIN (ACTH) AND THE ADRENAL STEROIDS IN THE MANAGEMENT OF ULCERATIVE COLITIS: OBSERVATIONS IN 240 PATIENTSJOSEPH B. KIRSNER, M.D., F.A.C.P., WALTER L. PALMER, M.D., F.A.C.P., JEAN A. SPENCER, M.D., RICHARD O. BICKS, M.D., CHARLES F. JOHNSON, M.D.JOSEPH B. KIRSNER, M.D., F.A.C.P., WALTER L. PALMER, M.D., F.A.C.P., JEAN A. SPENCER, M.D., RICHARD O. BICKS, M.D., CHARLES F. JOHNSON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-4-891 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe ultimate role of corticotropin (ACTH), the adrenal steroids (cortisone, hydrocortisone) and related compounds (prednisone and prednisolone) in the management of ulcerative colitis remains to be established. Though the immediate beneficial effects of corticoid therapy now are generally recognized,1, 2, 3, 4opinions vary.5, 6, 7The unfavorable reports frequently concern small groups of patients given medication irregularly, or as a substitute for all other forms of treatment. The possible dangers of hormonal therapy also have been emphasized,8, 9, 10though observers differ as to their incidence and importance.11, 12, 13, 14The literature on corticoid therapy of gastrointestinal...Bibliography1. Kirsner JB: Ulcerative colitis: observations on the etiology, course and management, Postgrad. Med. 22: 132, 1957. CrossrefMedlineGoogle Scholar2. TrueloveWitts SCLJ: Cortisone in ulcerative colitis, Brit. M. J. 2: 1041, 1957. CrossrefMedlineGoogle Scholar3. Truelove SC: Treatment of ulcerative colitis with local hydrocortisone, Brit. M. J. 2: 1267, 1956. CrossrefMedlineGoogle Scholar4. 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Author, Article, and Disclosure InformationAffiliations: *Received for publication May 12, 1958.Presented as a Morning Lecture at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 30, 1958.From the Department of Medicine, The University of Chicago.†This study was supported in part by grants from the National Institutes of Health (No. 95) and the Wallach Fund for Research in Gastrointestinal Diseases (University of Chicago).This study has been greatly facilitated by the continued generosity of the following pharmaceutical companies providing the various compounds: corticotropin (ACTH), Wilson and Co., Chicago; hydrocortisone, Upjohn and Co., Kalamazoo, Michigan; prednisone and prednisolone, Schering Corporation, Bloomfield, New Jersey.Requests for reprints should be addressed to Joseph B. Kirsner, M.D., Department of Medicine, The University of Chicago, Chicago 37, Illinois. 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WEINBERGER, M.D.Immediate and Prolonged Therapeutic Effects of Corticotrophin and Adrenal Steroids in Ulcerative ColitisThe surgical rehabilitation of patients with chronic ulcerative colitisReflections on aspects of ulcerative colitisColonic and anorectal function and diseaseReactivation of ulcerative colitis following closure of an ileostomy of 27 years' durationUlcerative Colitis in Older Age PatientsCORTICOSTEROIDS IN PREOPERATIVE MEDICAL MANAGEMENT OF ULCERATIVE COLITIS DO THEY AFFECT SURGICAL SUCCESS ?Clinical and pathologic observations in steroid-treated ulcerative colitisHypersensitivity, Autoimmunity, and the Digestive TractSerum Proteins in Ulcerative Colitis 1 April 1959Volume 50, Issue 4Page: 891-927KeywordsAdrenocorticotropic hormoneColitisEmotionsGraduate medical educationHemorrhageHormonal therapyResearch fundingSteroid therapySteroidsUlcerative colitis ePublished: 1 December 2008 Issue Published: 1 April 1959 PDF downloadLoading ...