tbuckley/cabot-search huggingface dataset:
JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition
Authors: Anna Sophia McKenney, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, Barbara Spitzer, Andrew M. Intlekofer, Jihae Ahn, Kaitlyn Shank, Franck T. Rapaport, Minal A. Patel, Efthymia Papalexi, Alan H. Shih, April Chiu, Elizaveta Freinkman, Esra A. Akbay, Mya Steadman, Raj Nagaraja, Katharine Yen, Julie Teruya-Feldstein, Kwok-Kin Wong, Raajit Rampal, Matthew G. Vander Heiden, Craig B. Thompson, Ross L. Levine
Journal: Journal of Clinical Investigation (2018)

Patients with myeloproliferative neoplasms (MPNs) frequently progress to bone marrow failure or acute myeloid leukemia (AML), and mutations in epigenetic regulators such as the metabolic enzyme isocitrate dehydrogenase (IDH) are associated with poor outcomes. Here, we showed that combined expression of Jak2V617F and mutant IDH1R132H or Idh2R140Q induces MPN progression, alters stem/progenitor cell function, and impairs differentiation in mice. Jak2V617F Idh2R140Q–mutant MPNs were sensitive to small-molecule inhibition of IDH. Combined inhibition of JAK2 and IDH2 normalized the stem and progenitor cell compartments in the murine model and reduced disease burden to a greater extent than was seen with JAK inhibition alone. In addition, combined JAK2 and IDH2 inhibitor treatment also reversed aberrant gene expression in MPN stem cells and reversed the metabolite perturbations induced by concurrent JAK2 and IDH2 mutations. Combined JAK2 and IDH2 inhibitor therapy also showed cooperative efficacy in cells from MPN patients with both JAK2mut and IDH2mut mutations. Taken together, these data suggest that combined JAK and IDH inhibition may offer a therapeutic advantage in this high-risk MPN subtype.
Characteristics of Interim Publications of Randomized Clinical Trials and Comparison With Final Publications
Authors: Steven Woloshin, Lisa M. Schwartz, Pamela J. Bagley, Heather B. Blunt, Brian White
Journal: JAMA (2018)

This study describes the number of interim reports of ongoing randomized trials published between 2006 and 2015, the reasons for interim reporting, and differences in the abstract conclusions between interim and final publications.
RX-3117, a Novel Nucleoside Analog Targeting UCK2 Is Active Alone and Synergistic with Ibrutinib and Bendamustine in ABC and DH/DP- Diffuse Large B-Cell Lymphoma
Authors: Shariful Islam, Umar Zahid, Laurence Cooke, Young Bok Lee, Deog Joong Kim, Ely Benaim, Daruka Mahadevan
Journal: Blood (2017)
Integrin α <sub>4</sub> β <sub>7</sub> expression on peripheral blood CD4 <sup>+</sup> T cells predicts HIV acquisition and disease progression outcomes
Authors: Aida Sivro, Alexandra Schuetz, Daniel Sheward, Vineet Joag, Sergey Yegorov, Lenine J. Liebenberg, Nonhlanhla Yende-Zuma, Andrew Stalker, Ruth S. Mwatelah, Philippe Selhorst, Nigel Garrett, Natasha Samsunder, Anisha Balgobin, Fatima Nawaz, Claudia Cicala, James Arthos, Anthony S. Fauci, Aggrey Omu Anzala, Joshua Kimani, Bernard S. Bagaya, Noah Kiwanuka, Carolyn Williamson, Rupert Kaul, Jo-Ann S. Passmore, Nittaya Phanuphak, Jintanat Ananworanich, Aftab Ansari, Quarraisha Abdool Karim, Salim S. Abdool Karim, Lyle R. McKinnon
Journal: Science Translational Medicine (2018)

CD4 + T cells expressing α 4 β 7 play an important role in HIV pathogenesis.
Abstract 16999: Cardiac and Systemic Rejuvenation in Senescent Rodents and Human Heart Cells Treated With Cardiosphere-derived Cells From Young Donors
Authors: Lilian Grigorian, Ryan Middleton, Weixin Liu, Antonio Echavez, Jackelyn Valle, Jae Hyung Cho, Eduardo Marban
Journal: Circulation (2017)

Introduction:  Presbycardia is characterized by diastolic dysfunction. Cardiosphere-derived cell (CDC) therapy has exhibited several favorable effects on heart structure and function in humans and in preclinical models; however, the effects of CDCs on aging have not been evaluated.   Hypothesis:  Young CDCs may rejuvenate aged hearts. To test this, we assessed the effects of CDCs on heart structure, function, gene expression and systemic parameters in senescent models and explored underlying mechanisms of action.   Methods:  We compared intra-cardiac injections of neonatal rat CDCs or monthly doses of CDC-derived exosomes (CDC-XO) to vehicle (phosphate-buffered saline, PBS) in 2-year-old rats in two independent and consecutive studies (n=51 total). Ten rats 4.1±1.5 months of age comprised a young reference group. Rats were followed for 1- and 4-months in CDC and CDC-XO studies, respectively. For in vitro studies, human heart progenitors from older donors, or cardiomyocytes from aged rats were exposed to human CDCs or CDC-XO from pediatric donors.   Results:  Transcriptomic analysis revealed that CDCs, but not PBS, recapitulated a youthful pattern of gene expression (p   Conclusions:  Young CDCs and CDC-XO rejuvenate old animals as gauged by cardiac gene expression, heart function, exercise capacity and systemic biomarkers.
Abstract 20614: Evaluation of Ablation Catheter Technology: Comparison Between the Thigh Preparation Model and an In-Vivo Beating Heart
Authors: Eran Leshem, Cory M Tschabrunn, Israel Zilberman, Elad Anter
Journal: Circulation (2016)

Background:  An  in-vivo  animal thigh model is the standard technique for evaluation of ablation catheter technologies, including for prediction of ablation efficacy (lesion dimensions) and safety (cardiac tissue perforation and collateral damage). However, validation of this model with an  in-vivo  beating heart has not been performed. The purpose of this study was to prospectively compare these two methods.   Methods:  In 5 Yorkshire swine, radiofrequency ablation using a 3.5mm open irrigated catheter (Thermocool Smart Touch®) was performed sequentially in the thigh muscle and the beating ventricles. Ablation was performed in 2 settings: 30W for 40Ssec (low energy) and 40W for 60Sec (high energy) at similar tissue contact (8-14 grams). Tetrazolium chloride was injected 15 minutes prior to euthanasia and all tissue were fixed in formalin for ≥7 days. Ablation lesions were scanned in high-resolution and measured using electronic calipers.   Results:  A total of 114 RF ablation lesions were measured (57 for each method). In the low energy setting, lesion width was greater in the thigh model (8.37±1.5mm vs. 7.14±1.3mm; p=0.005) while lesion depth was greater in the beating heart (4.72±0.8mm vs. 4.2±0.6mm; p=0.016). The overall lesion volume was similar between the methods (thigh 27.8±7.1mm 2  vs. heart 26.9±7.9mm 2 ; p=0.74). In the high energy setting, lesion depth, width, and overall volume were greater in the thigh lesions (thigh 53.9±10.8mm 2  vs. heart 34.5±9.6mm 2 ; p=0.001). The thigh model demonstrated consistent and predictable lesions compared to the beating heart (r=0.75 vs r=0.53, respectively). There was no difference in steam pop incidence.   Conclusion:  The thigh model is a reasonable technique for evaluation of ablation catheter technology. The correlation of lesion dimensions between thigh model and beating heart is reasonable in low energy settings, however results in overestimation at higher energy setting. Caution should be taken before extrapolation of ablation data obtained using the thigh model technique to the beating heart physiology.
Adaptability of Antibody-Coupled T Cell Receptor (ACTR) Engineered Autologous T Cells in Combination with Daratumumab over CAR-Based Approaches
Authors: Taylor Hickman, Adrianna Graziano, Katie O'Callaghan, Ryan Boomer, Eugene Choi, Allison Nelson, Greg Motz, Jessica Sachs, Birgit Schultes, Seth Ettenberg, Tooba Cheema
Journal: Blood (2017)
Rapid increase in non-vaccine serotypes causing invasive pneumococcal disease in England and Wales, 2000–17: a prospective national observational cohort study
Authors: Shamez N Ladhani, Sarah Collins, Abdelmajid Djennad, Carmen L Sheppard, Ray Borrow, Norman K Fry, Nicholas J Andrews, Elizabeth Miller, Mary E Ramsay
Journal: The Lancet Infectious Diseases (2018)
Effect of Epicutaneous Immunotherapy on Inducing Peanut Desensitization in Peanut-Allergic Children: Topline Peanut Epicutaneous Immunotherapy Efficacy and Safety (PEPITES) Randomized Clinical Trial Results
Authors: David M. Fleischer, Gordon Lloyd Sussman, Philippe Begin, Anna H. Nowak-Wegrzyn, Kirsten Beyer, Stephen A. Tilles, Terri F. Brown-Whitehorn, Jacques Hébert, Jonathan O'B. Hourihane, Dianne Campbell, Stephanie A. Leonard, Sharon Chinthrajah, Jacqueline A. Pongracic, Stacie M. Jones, Lars Lange, Todd David Green, Robert A. Wood, Wayne G. Shreffler
Journal: Journal of Allergy and Clinical Immunology (2018)
A Single Direct Intratumoral Injection of TTI-621 (SIRPαFc) Induces Antitumor Activity in Patients with Relapsed/Refractory Mycosis Fungoides and Sézary Syndrome: Preliminary Findings Employing an Immune Checkpoint Inhibitor Blocking the CD47 Do Not Eat Signal
Authors: Christiane Querfeld, John Thompson, Matthew Taylor, Raju Pillai, Lisa Ds Johnson, Tina Catalano, Penka S. Petrova, Robert A. Uger, Meghan Irwin, Eric L Sievers, Oleg E. Akilov
Journal: Blood (2017)
P53 and P16 Protein Expression Have Prognostic Value in Mantle Cell Lymphomas in the Lyma Trial in the Lysa Group
Authors: Danielle Canioni, Barbara Burroni, Anne Moreau, Alexandra traverse-Glehen, Antoine Martin, Remy Gressin, Vincent Ribrag, Catherine Thieblemont, Marie-Helene Delfau-Larue, Elizabeth A. Macintyre, Mary Callanan, Steven Le Gouill, Olivier Hermine
Journal: Blood (2017)
Lack of the BH3-Only Proteins Bim, Bmf and Puma In Haematopoietic Stem and Progenitor Cells Facilitates Early Reconstitution and Long Term Haematopoiesis.
Authors: Miriam Erlacher, Daniela Bertele, Claudia Woess, Charlotte Marie Niemeyer, Andreas Villunger, Verena Labi
Journal: Blood (2010)
Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study
Authors: Giuseppe Giaccone, Chul Kim, Jillian Thompson, Colleen McGuire, Bhaskar Kallakury, Joeffrey J Chahine, Maria Manning, Robin Mogg, Wendy M Blumenschein, Ming T Tan, Deepa S Subramaniam, Stephen V Liu, Ian M Kaplan, Justine N McCutcheon
Journal: The Lancet Oncology (2018)
Baseline PET-Derived Metabolic Tumor Volume Metrics Predict Progression-Free and Overall Survival in DLBCL after First-Line Treatment: Results from the Phase 3 GOYA Study
Authors: Lale Kostakoglu, Maurizio Martelli, Laurie H. Sehn, David Belada, Angelo-Michele Carella, Neil Chua, Eva Gonzalez-Barca, Xiaonan Hong, Antonio Pinto, Yuankai Shi, Yoichi Tatsumi, Günter Fingerle-Rowson, Andrea Knapp, Federico Mattiello, Tina Nielsen, Gila Sellam, Denis Sahin, Umberto Vitolo, Marek Trněný
Journal: Blood (2017)
Abstract 18663: Rivaroxaban, but Not PAR-2 Antagonist, Attenuates Cardiac Remodeling Due to Intermittent Hypoxia in Sleep Apnea Model Mice
Authors: Saki Morita, Ayumi Fujiwara, Toshiki Kondo, Kenji Fujii, Hideki Imano, Ryuji Kato, Yoshio Ijiri, Takehiro Yamaguchi, Yasukatsu Izumi, Minoru Yoshiyama, Tetsuya Hayashi
Journal: Circulation (2016)

Introduction:  The cumulative frequency of atrial fibrillation (AF) is high in patients with sleep apnea. We have reported that intermittent hypoxia (IH) relevant to sleep apnea increases oxidative stress causing vascular remodeling. Recently, pleiotropic effects of serine protease factor Xa (FXa) have been reported. The aim of study was to investigate the effect of FXa inhibitor rivaroxaban on atrial and ventricular remodeling caused by IH relevant to sleep apnea in vivo and in vitro.   Methods:  Male C57BL/6J mice were exposed to IH (repeated cycles of 1.5 min of 5% oxygen followed by 5 min of 21% oxygen) for 28 days with/without treatment by rivaroxaban (1.2 g riv./kg chow) or protease-activated receptor (PAR)-2 antagonist (FSLLRY-NH 2 , 10 μg/kg/day). Human pulmonary artery endothelial cells were cultured under hypoxic conditions (1% oxygen for 24 hr) with/without rivaroxaban (1 μM) or FSLLRY-NH 2  (10μM).   Results:  IH caused cardiac remodeling, associated with both systolic and diastolic dysfunction (IH-vehicle vs. Normoxia; EF: 51% vs. 60% and E/e’: 29.4 vs. 22.3), which were attenuated by rivaroxaban (EF:56%, E/e’ 24.6), but not by FSLLRY (EF: 52%, E/e’: 25.1). In right atrial myocardium, IH caused endothelial cell degeneration, dissociation of intercalated discs, vacuolar formation and loss of ANP specific granules. Furthermore, 4-hydroxy-2-nonenal protein adducts and the expressions of PAR-2, ERK1/2 and NF-kB mRNA in the left ventricular myocardium were increased by IH. Treatment with rivaroxaban significantly suppressed PAR-2, ERK1/2 and NF-kB mRNA expressions in vitro, reduced oxidative stress and degeneration of small arteries, but not observed in treatment with the PAR-2 antagonist, preventing atrial as well as ventricular remodeling due to IH.   Conclusions:  Both rivaroxaban and FSLLRY-NH2 exert anti-inflammatory effects via the PAR-2/ERK/NF-κB signaling pathway. Rivaroxaban, but not PAR-2 antagonist, reduces oxidative stress and attenuates capillary endothelial cell degeneration and thrombosis induced by IH in atrial appendage, which might be a novel therapeutic strategy by FXa inhibition against atrial remodeling in patients with AF.
Co-Transplantation of CAR-Gene Engineered Precursor T Cells Leads to Suppressed T Cell Development and Increased NK Cell-Based CAR-Mediated Anti-Leukemic Activity
Authors: Marcel Maluski, Jessica Herbst, Vanessa Scholl, Rolf Baumann, Niels Heinz, Robert Geffers, Johann Meyer, Andreas Krueger, Axel Schambach, Martin G. Sauer
Journal: Blood (2017)
High-risk human papillomavirus (HPV) genotypes in Jamaican women
Authors: Angela Watt, Camille Ragin, Novie Younger, David Garwood, Maria Jackson, Monica Smikle, Horace Fletcher, Norma McFarlane-Anderson
Journal: Cancer Research (2007)

LB-122   Infection with high-risk HPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) is considered the main cause of cervical cancer. There is currently increasing interest in these genotypes because of the development of a prophylactic vaccine that targets HPV 6, 11, 16, and 18. In Jamaica, the prevalence of cervical cancer remains high at 27.6/100,000. We studied the presence of high-risk HPV genotypes in a population of Jamaican women and determined whether there were any associations with lifestyle and sexual practices. A total of 253 women were recruited for the study, 137 pregnant women aged 15-44 years recruited at their first antenatal visit to the University Hospital of the West Indies (UHWI) from August - October 2006 and 116 non-pregnant women aged 19-83 years attending a family practice in Western Jamaica from January 2003 - October 2006. After completion of a lifestyle/sexual practice questionnaire, cervical cell samples were collected from the women. HPV DNA was detected using Polymerase Chain Reaction and Reverse Line Hybridization. Data were analyzed using SPSS version 12. HPV detection was carried out on cervical cell samples from 236 women. HPV DNA was detected in 87.7% (207/236) and of these 81.2% (168/207) was positive for high-risk types. The significant difference in HPV detection previously observed using urine samples (OR, 7.8, CI, 3.6-16.8) between pregnant and non-pregnant women was not observed using cervical cells. The presence of high-risk infections approached significance (p=0.059). Multiple infections were detected in 66.9% (83/124) and 51.8% (43/83) of pregnant and non-pregnant women respectively. Logistic regression analysis confirmed an association between the presence of multiple infections and pregnancy (OR = 2.0, 95% CI, 1.18-3.38; p = 0.01). Presence of bacterial vaginosis was associated with multiple infections (OR = 3.5; CI, 1.26-9.82 p =0.017). Of the HPV positive samples, the most common high-risk HPV types were: HPV 45: 21.7%, HPV 58: 18.8%, HPV 16: 18.4%, HPV 35: 15.0%, HPV 18: 14.5%, HPV 52: 12.0%, HPV 51: 11.1%. Other high-risk types were present in frequencies of 1.4% - 7.2%. The high rates of high-risk HPV types and multiple infections are of concern and in part could explain the continued high prevalence of cervical cancer in Jamaica. The fact that HPV 45 was found to be the most prevalent genotype is in keeping with an earlier report of a high prevalence of this genotype in another Caribbean territory (Tobago) and in Jamaican UHWI colposcopy patients. These data suggest that it may be necessary to consider development of other vaccines which target these genotypes.
Abstract P177: Projected Change in Outpatient Management of Blood Pressure in the United States with the Implementation Of JNC-8 as Compared to JNC-7 Criteria
Authors: Sunil K Agarwal, Ines Sherifi, Nidhi Tripathi, Jonathan Halperin
Journal: Circulation (2016)

Background: The 2014 Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-8) hypertension management guidelines support less restrictive blood pressure (BP) criteria among patients with age ≥ 60, diabetes or chronic kidney disease than the 2007 recommendations (JNC-7). We compared the proportion of patients for whom treatment escalation is recommended according to the JNC-8 guidelines vs. JNC-7. Methods and Results: We analyzed the National Ambulatory Medical Care Survey 2008-2010 dataset of about 76,000 US adult (&gt;18 years old) outpatient visits representing 820 million annual outpatient visits. A clinical history of hypertension was present in 33.3%, and BP was recorded at 67.1% of all visits. Of these, 41.7% clinic visits involved patients ≥60 years old, and 15.5% included those with diabetes or non-diabetic renal disease. We restricted further analysis to those with measured blood pressure. Among patients without a prior diagnosis of hypertension, BP management should be initiated for 6% fewer patients (13.4% vs. 19.4%, p&lt;0.001) for the JNC-8 guidelines than JNC-7 criteria, respectively. In those with a prior diagnosis of hypertension, BP treatment escalation was needed in 17.7% fewer patients (28.8% vs. 46.5%, p&lt;0.001) for the JNC-8 than JNC-7 criteria. The difference of overall patients needing either treatment initiation or escalation was obviously more apparent among those ≥ age 60 years with 23.4% lesser patients (21.8 vs. 45.2%, p&lt;0.001) as well as those with renal disease or diabetes with 31.3% lesser patients (27.1 vs. 58.4% p&lt;0.001). Conclusions: In this U.S. representative sample of outpatient visits, implementation of the JNC-8 hypertension guidelines decreases the need for initiation or intensification of anti-hypertensive treatment in about one out of six outpatients visits than JNC-7 guidelines. Thus, such shifts may influence treatment decisions for more than 100 million outpatient encounters annually. The actual implementation and associated change in patient outcomes need to be studied.
Improved adenoma detection with Endocuff Vision: the ADENOMA randomised controlled trial
Authors: Wee Sing Ngu, Roisin Bevan, Zacharias P Tsiamoulos, Paul Bassett, Zoë Hoare, Matthew D Rutter, Gayle Clifford, Nicola Totton, Thomas J Lee, Arvind Ramadas, John G Silcock, John Painter, Laura J Neilson, Brian P Saunders, Colin J Rees
Journal: Gut (2018)

Objective Low adenoma detection rates (ADR) are linked to increased postcolonoscopy colorectal cancer rates and reduced cancer survival. Devices to enhance mucosal visualisation such as Endocuff Vision (EV) may improve ADR. This multicentre randomised controlled trial compared ADR between EV-assisted colonoscopy (EAC) and standard colonoscopy (SC). Design Patients referred because of symptoms, surveillance or following a positive faecal occult blood test (FOBt) as part of the Bowel Cancer Screening Programme were recruited from seven hospitals. ADR, mean adenomas per procedure, size and location of adenomas, sessile serrated polyps, EV removal rate, caecal intubation rate, procedural time, patient experience, effect of EV on workload and adverse events were measured. Results 1772 patients (57% male, mean age 62 years) were recruited over 16 months with 45% recruited through screening. EAC increased ADR globally from 36.2% to 40.9% (P=0.02). The increase was driven by a 10.8% increase in FOBt-positive screening patients (50.9% SC vs 61.7% EAC, P&lt;0.001). EV patients had higher detection of mean adenomas per procedure, sessile serrated polyps, left-sided, diminutive, small adenomas and cancers (cancer 4.1% vs 2.3%, P=0.02). EV removal rate was 4.1%. Median intubation was a minute quicker with EAC (P=0.001), with no difference in caecal intubation rate or withdrawal time. EAC was well tolerated but caused a minor increase in discomfort on anal intubation in patients undergoing colonoscopy with no or minimal sedation. There were no significant EV adverse events. Conclusion EV significantly improved ADR in bowel cancer screening patients and should be used to improve colonoscopic detection. Trial registration number NCT02552017 , Results; ISRCTN11821044 , Results.
The communicative function of destination memory
Authors: Mohamad El Haj, Ralph Miller
Journal: Behavioral and Brain Sciences (2018)

Abstract Mahr &amp; Csibra's (M&amp;C's) proposal that episodic memory has a role in communicative interaction is innovative. However, the model would be strengthened by the inclusion of the construct of destination memory. Destination memory refers to the ability to remember to whom one has sent information. Research has demonstrated that this ability is essential for communicative efficacy and daily interactions with others.
Increased C-Reactive Protein Level Is Associated with Poor Prognosis in Patients with Follicular Lymphoma Treated with Rituximab-Containing Regimens
Authors: Yukiko Kawaguchi, Bungo Saito, Yohei Sasaki, Shotaro Shimada, Megumi Watanuki, Maasa Abe, So Murai, Yuta Baba, Shun Fujiwara, Nana Arai, Nobuyuki Kabasawa, Hiroyuki Tsukamoto, Yui Uto, Kouji Yanagisawa, Norimichi Hattori, Eisuke Shiozawa, Masafumi Takimoto, Tsuyoshi Nakamaki
Journal: Blood (2017)
Comparison of three surgical fixation methods for dual-bone forearm fractures in older children: A retrospective cohort study
Authors: Wenhao Zheng, Zhenyu Tao, Chunhui Chen, Chuanxu Zhang, Hui Zhang, Zhenhua Feng, Hang Li, Liang Cheng, Leyi Cai, Hua Chen
Journal: International Journal of Surgery (2018)
Distribution Of Human Respiratory Dendritic Cell Subsets At Steady State Differs In Specific Compartments Of The Airways
Authors: Gregory D. Rankin, S. Thomas, F. Baharom, Jamshid Pourazar, Anders Blomberg, Clas Ahlm, A. Smed-Sorensen
Journal: American Journal of Respiratory and Critical Care Medicine (2015)

Distribution Of Human Respiratory Dendritic Cell Subsets At Steady State Differs In Specific Compartments Of The Airways
Evolution of Platelet Function and Bleeding in Children and Adults with Chronic Immune Trombocytopenia on Romiplostim Treatment
Authors: Anastasia Ignatova, Elena Suntsova, Pavel Zharkov, Valentina Ivanova, Irina Demina, Aleksandr Poletaev, Elena Seregina, Dmitrii Polokhov, Natalia Smetanina, Alexey A Maschan, Mikhail Maschan, Galina Novichkova, Mikhail Panteleev
Journal: Blood (2017)
The Clinical Impact of Different Adherence Behaviors in Patients with Severe Chronic Obstructive Pulmonary Disease
Authors: Breda Cushen, Imran Sulaiman, Garrett Greene, Elaine MacHale, Matshediso Mokoka, Richard B. Reilly, Kathleen Bennett, Frank Doyle, Job F. M. van Boven, Richard W. Costello
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Definition of abbreviations: COPD = chronic obstructive pulmonary disease; GOLD = Global Initiative for Chronic Obstructive Lung Disease (GOLD grade based on GOLD 2015 guidelines); INCA = inhaler compliance assessment; MRC = Medical Research Council.Data are presented as mean (SD) unless otherwise stated.Comparison of characteristics across adherence clusters was performed using an unpaired t test or ANOVA for multiple comparisons.A chi-squared test was used for the comparison of proportional data.*P , 0.05 compared with cluster 1. † P , 0.01 compared with cluster 1.