tbuckley/cabot-search huggingface dataset:
Diversity of nontuberculous mycobacteria in eastern and southern China: a cross-sectional study
Authors: Yu Pang, Yaoju Tan, Jin Chen, Yanming Li, Huiwen Zheng, Yuanyuan Song, Yanlin Zhao
Journal: European Respiratory Journal (2017)

Nontuberculous mycobacteria (NTM) are a heterogeneous group of widely distributed environmental bacteria [1]. Despite generally low pathogenicity in humans, NTM can cause various illnesses especially in HIV-infected patients or those with immunodeficiencies [2]. In recent years, NTM-related disease incidence has increased significantly [3] and, despite China's tuberculosis (TB) programme having more than halved TB prevalence over the past 20 years [4], population-based data indicate that the proportion of NTM among all mycobacterial patient isolates has increased from 11.1% to 22.9% [5], triggering public health concerns. Nontuberculous mycobacterial infections in China: regional predominance of M. intracellulare and M. abscessus <http://ow.ly/vg3H306YH8c>
Flow Cytometric Detection of Human Telomerase Reverse Transcriptase Expression in CD34 Positive Precursor Fraction in Myelodysplastic Syndrome Bone Marrow.
Authors: Hiroshi Handa, Takafumi Matsushima, Norifumi Tsukamoto, Masamitsu Karasawa, Hiroyuki Irisawa, Takayuki Saito, Akihiko Yokohama, Arito Yamane, Hirokazu Murakami
Journal: Blood (2006)
CD4+ CD25high Regulatory T Cells in Newly Diagnosed Patients with Acute Myeloid Leukemia.
Authors: Miroslaw J. Szczepanski, Laura Strauss, Malgorzata Czystowska, Marta Szajnik, Ann Welsh, Kenneth A. Foon, Theresa L. Whiteside, Michael Boyiadzis
Journal: Blood (2007)
Confidentiality Issues and Use of Sexually Transmitted Disease Services Among Sexually Experienced Persons Aged 15–25 Years — United States, 2013–2015
Authors: Jami S. Leichliter, Casey Copen, Patricia J. Dittus
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

National-level data are limited regarding confidentiality-related issues and the use of sexually transmitted disease (STD) services for adolescents and young adults. Changes in the U.S. health care system have permitted dependent children to remain on a parent's health insurance plan until the child's 26th birthday and required coverage of certain preventive services, including some STD services, without cost sharing for most plans (1,2). Although these provisions likely facilitate access to the health care system, adolescents and young adults might not seek care or might delay seeking care for certain services because of concerns about confidentiality, including fears that their parents might find out (3,4). Therefore, it is important to examine STD services and confidentiality-related issues among persons aged 15-25 years in the United States. CDC analyzed data from the 2013-2015 National Survey of Family Growth and found that 12.7% of sexually experienced youths (adolescents aged 15-17 years and those young adults aged 18-25 years who were on a parent's insurance plan) would not seek sexual and reproductive health care because of concerns that their parents might find out. Particularly concerned were persons aged 15-17 years (22.6%). Females with confidentiality concerns regarding seeking sexual and reproductive health care reported a lower prevalence of receipt of chlamydia screening (17.1%) than did females who did not cite such concerns (38.7%). More adolescents aged 15-17 years who spent time alone with a health care provider (without a parent in the room) reported receipt of a sexual risk assessment (71.1%) and, among females, chlamydia testing (34.0%), than did those who did not spend time alone (36.6% and 14.9%, respectively). The results indicated that confidentiality-related issues were associated with less reported use of some STD services, especially for younger persons and females. Spending time alone with a provider (i.e., without a parent present) during a health care visit has been associated previously with higher reported delivery of sexual health services (5) and has been suggested by the American Academy of Pediatrics and Society for Adolescent Health and Medicine (6). Public health efforts related to confidentiality of STD services might be helpful to increase the use of recommended services among some youths.
Patient Access and 1-Year Outcomes of Percutaneous Coronary Intervention Facilities With and Without On-Site Cardiothoracic Surgery
Authors: Thomas M. Maddox, Maggie A. Stanislawski, Colin O’Donnell, Mary E. Plomondon, Steven M. Bradley, P. Michael Ho, Thomas T. Tsai, Adhir R. Shroff, Bernadette Speiser, Robert J. Jesse, John S. Rumsfeld
Journal: Circulation (2014)

The safety of percutaneous coronary intervention (PCI) at medical facilities without on-site cardiothoracic (CT) surgery has been established in clinical trials. However, the comparative effectiveness of this strategy in real-world practice, including impact on patient access and outcomes, is uncertain. The Veterans Affairs (VA) health care system has used this strategy, with strict quality oversight, since 2005, and can provide insight into this question.Among 24,387 patients receiving PCI at VA facilities between October 2007 and September 2010, 6616 (27.1%) patients underwent PCI at facilities (n=18) without on-site CT surgery. Patient drive time (as a proxy for access), procedural complications, 1-year mortality, myocardial infarction, and rates of subsequent revascularization procedures were compared by facility. Results were stratified by procedural indication (ST-segment-elevation myocardial infarction versus non-ST-segment-elevation myocardial infarction/unstable angina versus elective) and PCI volume. With the inclusion of PCI facilities without on-site CT surgery, median drive time for patients treated at those facilities decreased by 90.8 minutes (P<0.001). Procedural need for emergent coronary artery bypass graft and mortality rates were low and similar between facilities. Adjusted 1-year mortality and myocardial infarction rates were similar between facilities (hazard ratio in PCI facilities without relative to those with on-site CT surgery, 1.02; 95% confidence interval, 0.87-1.2), and not modified by either PCI indication or PCI volume. Subsequent revascularization rates were higher at sites without on-site CT surgery facilities (hazard ratio, 1.21; 95% confidence interval, 1.03-1.42).This study suggests that providing PCI facilities without on-site CT surgery in an integrated health care system with quality oversight improves patient access without compromising procedural or 1-year outcomes.
Primary Diffuse Large B-Cell Lymphoma of the Colon: Surgery for Local Disease Control Does Not Improve Outcome.
Authors: Rajini Katipamula, Kay Ristow, Joseph P. Colgan, Thomas M. Habermann, Patrick B. Johnston, David J. Inwards, Svetomir N. Markovic, Ivana N. Micallef, Luis F. Porrata, William L. White, Thomas E. Witzig, Stephen M. Ansell
Journal: Blood (2007)
First Estimates of Incidence of Progressive Multifocal Leukoencephalopathy Developing Among 10,459 Non-HIV Lymphoma VA Patients Who Receive Rituximab: Results From the Veterans Administration Database (1999–2012).
Authors: Gowtham Rao, Peter Georgantopoulos, Kathlyn Sue Haddock, Kenneth R. Carson, LeAnn Norris, Oliver Sartor, Charles Bennett
Journal: Blood (2012)
Disruption of the Peripheral Lymphoid Niche Contributes to Lymphopenia in CML Patients Undergoing Imatinib Treatments
Authors: Stephanie Thiant, Moutuaata M.Moutuou, Philippe Laflamme, Radia Sidi Boumedine, Fanny Larochelle, Dominique Leboeuf, Denis-Claude Roy, Martin Guimond
Journal: Blood (2015)
Genome-wide analyses identify common variants associated with macular telangiectasia type 2
Authors: Thomas S Scerri, Anna Quaglieri, Carolyn Cai, Jana Zernant, Nori Matsunami, Lisa Baird, Lea Scheppke, Roberto Bonelli, Lawrence A Yannuzzi, Martin Friedlander, Catherine A Egan, Marcus Fruttiger, Mark Leppert, Rando Allikmets, Melanie Bahlo
Journal: Nature Genetics (2017)
The Prognostic Significance of Phenotypically ‘Normal’ Plasma Cells in Chemotherapy Treated AL Patients with Underlying MGUS and Multiple Myeloma
Authors: Sajitha Sachchithanantham, Ruth M de Tute, Anna Baginska, Christopher Parrish, Shameem Mahmood, Andy Rawstron, Julian D Gillmore, Helen J Lachmann, Philip N Hawkins, Roger G Owen, Ashutosh Wechalekar
Journal: Blood (2014)
Strategies to Enhance the Efficacy of Platelet-Derived Factor (F) VIII: Studies with Inactivation Resistant FVIII (IR8) and Canine FVIII in Hemophilia A Mice.
Authors: Teshell K. Greene, Cheng Wang, Jessica Hirsch, Hongzhi Miao, Steven W. Pipe, M. Anna Kowalska, Mortimer Poncz
Journal: Blood (2009)
In Vitro Exploratory Studies of Haptoglobin Polymorphisms and Their Effect on Cytokine Release from Cultured Mononuclear Cells in Sickle Cell Disease.
Authors: Komal Bora, Kavita Natarajan, Ferdane Kutlar, Hanfang Zhang, Hongyan Xu, Betsy Clair, Kathleen M McKie, Abdullah Kutlar
Journal: Blood (2008)
Abstract IA26: Changes in diet and microbiome that mitigate CRC risk in Native Africans vs. African Americans
Authors: Stephen J. O'Keefe
Journal: Cancer Research (2017)

Abstract Colon cancer is an environmental disease associated with westernization, and it has been shown that it takes one generation for immigrants to change their risk of cancer. To investigate the role of the western diet in driving this change, we have switched the macronutrient composition of diets of groups of 20 healthy middle aged African Americans, who have the highest risk of colon cancer in the USA (~65:100,000) and rural Africans, who rarely get the disease (&amp;lt;5:100,000) and measured its impact on mucosal biomarkers of cancer risk and the colonic microbiota that we hypothesize regulate this risk. Twenty healthy middle-aged volunteers from each community were housed for two weeks so that food could be prepared and consumed under close supervision. Americans were given a “traditional African” diet, high in fiber and low in meat and fat, while Africans were given a western diet, high in meat and fat, low in fiber. Mucosal biopsies taken from the proximal, mid and distal colon at colonoscopy before and after the dietary switch showed significant suppression of inflammation and proliferation cancer biomarkers in Americans and increases in Africans. In keeping with our hypothesis, these changes were associated with changes in bacterial co-occurrences, notably those of butyrate producers, and their metabolomic phenotypes. Targeted analysis of microbes associated with saccharolytic fermentation and their products, short chain fatty acids, showed that they were strongly associated with suppression of cancer biomarkers, whilst microbes associated with bile acid deconjugation and secondary bile acid production exhibited the reverse, providing a mechanism for the strong epidemiological evidence that fiber reduces risk and fat, by increasing the hepatic synthesis of bile acids, increases risk. In conclusion, our results build on the observation that the incidence of colon cancer changes within one generation of westernization by showing that the mucosal changes associated with carcinogenesis change within two weeks of switching to a western diet and provide evidence that the change is mediated by colonic microbial metabolism. Citation Format: Stephen J. O'Keefe. Changes in diet and microbiome that mitigate CRC risk in Native Africans vs. African Americans. [abstract]. In: Proceedings of the AACR Special Conference on Colorectal Cancer: From Initiation to Outcomes; 2016 Sep 17-20; Tampa, FL. Philadelphia (PA): AACR; Cancer Res 2017;77(3 Suppl):Abstract nr IA26.
Editing Human Lymphocyte Specificity for Safe and Effective Adoptive Immunotherapy of Leukemia.
Authors: Elena Provasi, Pietro Genovese, Angelo Lombardo, Zulma Magnani, Andreas Reik, Pei-Qi Liu, Victoria Chu, Jurgen Kuball, Attilio Bondanza, Giulia Casorati, Fabio Ciceri, Claudio Bordignon, Philip D. Greenberg, Michael C. Holmes, Philip D. Gregory, Luigi Naldini, Chiara Bonini
Journal: Blood (2010)
Third of patients report severe discomfort after anaesthesia
Authors: Jacqui Wise
Journal: BMJ (2017)

A third of patients report severe discomfort after anaesthesia, and women are three times more likely to experience it than men, a comprehensive national snapshot of patient reported outcomes has found.

But the study, published in the British Journal of Anaesthesia ,1 found that, despite this burden of perioperative symptoms, almost all patients surveyed were very satisfied with the level of care they …
Abstract P5-04-01: Cell cycle dynamics at single cell level dictates response to CDK4/6 inhibition
Authors: U Asghar, A Barr, R Cuts, M Beaney, I Babina, D Sampath, J Lacap, L Crocker, A Young, A Nerukar, A Pearson, M Herrera-Abreu, C Bakal, N Turner
Journal: Cancer Research (2017)

Abstract This abstract was withdrawn by the authors.
Gatekeeper Mutations and Intratumoral Heterogeneity in<i>FGFR2</i>-Translocated Cholangiocarcinoma
Authors: Elizabeth C. Smyth, Irina S. Babina, Nicholas C. Turner
Journal: Cancer Discovery (2017)

Abstract Summary: FGFR2 genetic translocations are frequent in cholangiocarcinoma, yet despite initial sensitivity to FGFR inhibitors in clinic, patients quickly become resistant to targeted therapies. The work published by Goyal and colleagues demonstrates that acquisition of gatekeeper mutations in FGFR2 and intratumoral heterogeneity drive resistance in patients with FGFR2-translocated intrahepatic cholangiocarcinoma, which will have important implications for management of the disease in clinic. Cancer Discov; 7(3); 248–9. ©2017 AACR. See related article by Goyal et al., p. 252.
Outcomes of Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia Based on Blast Genotype at Diagnosis: A Report from the Children's Oncology Group
Authors: Mignon L. Loh, Elizabeth Raetz, Meenakshi Devidas, Yunfeng Dai, Michael J. Borowitz, Andrew J. Carroll, I-Ming Chen, Julie M. Gastier-Foster, Alison M. Friedmann, Richard C. Harvey, Nyla A. Heerema, Eric Larsen, Yongjin Li, Kelly W. Maloney, Leonard A. Mattano, Charles G. Mullighan, Karen R. Rabin, Shalini C. Reshmi, Kathryn G. Roberts, Cheryl L. Willman, Brent L. Wood, Patrick Zweidler-McKay, Jinghui Zhang, Naomi Winick, Stephen Hunger, William L. Carroll
Journal: Blood (2016)
hnRNP K Overexpression Synergizes with Mutant NPM1 to Drive Acute Myeloid Leukemia Progression
Authors: Miguel Gallardo, Hun Ju Lee, Xiaorui Zhang, Laura R. Pageon, Asha Multani, Markus Reschke, John G Clohessy, Alfonso Quintás-Cardama, Michael Andreeff, Steven M. Kornblau, Pier Paolo Pandolfi, Sean M. Post
Journal: Blood (2014)
Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone
Authors: Peter J. Snyder, David L. Kopperdahl, Alisa J. Stephens-Shields, Susan S. Ellenberg, Jane A. Cauley, Kristine E. Ensrud, Cora E. Lewis, Elizabeth Barrett-Connor, Ann V. Schwartz, David C. Lee, Shalender Bhasin, Glenn R. Cunningham, Thomas M. Gill, Alvin M. Matsumoto, Ronald S. Swerdloff, Shehzad Basaria, Susan J. Diem, Christina Wang, Xiaoling Hou, Denise Cifelli, Darlene Dougar, Bret Zeldow, Douglas C. Bauer, Tony M. Keaveny
Journal: JAMA Internal Medicine (2017)

<h3>Importance</h3> As men age, they experience decreased serum testosterone concentrations, decreased bone mineral density (BMD), and increased risk of fracture. <h3>Objective</h3> To determine whether testosterone treatment of older men with low testosterone increases volumetric BMD (vBMD) and estimated bone strength. <h3>Design, Setting, and Participants</h3> Placebo-controlled, double-blind trial with treatment allocation by minimization at 9 US academic medical centers of men 65 years or older with 2 testosterone concentrations averaging less than 275 ng/L participating in the Testosterone Trials from December 2011 to June 2014. The analysis was a modified intent-to-treat comparison of treatment groups by multivariable linear regression adjusted for balancing factors as required by minimization. <h3>Interventions</h3> Testosterone gel, adjusted to maintain the testosterone level within the normal range for young men, or placebo gel for 1 year. <h3>Main Outcomes and Measures</h3> Spine and hip vBMD was determined by quantitative computed tomography at baseline and 12 months. Bone strength was estimated by finite element analysis of quantitative computed tomography data. Areal BMD was assessed by dual energy x-ray absorptiometry at baseline and 12 months. <h3>Results</h3> There were 211 participants (mean [SD] age, 72.3 [5.9] years; 86% white; mean [SD] body mass index, 31.2 [3.4]). Testosterone treatment was associated with significantly greater increases than placebo in mean spine trabecular vBMD (7.5%; 95% CI, 4.8% to 10.3% vs 0.8%; 95% CI, −1.9% to 3.4%; treatment effect, 6.8%; 95% CI, 4.8%-8.7%;<i>P</i> &lt; .001), spine peripheral vBMD, hip trabecular and peripheral vBMD, and mean estimated strength of spine trabecular bone (10.8%; 95% CI, 7.4% to 14.3% vs 2.4%; 95% CI, −1.0% to 5.7%; treatment effect, 8.5%; 95% CI, 6.0%-10.9%;<i>P </i>&lt; .001), spine peripheral bone, and hip trabecular and peripheral bone. The estimated strength increases were greater in trabecular than peripheral bone and greater in the spine than hip. Testosterone treatment increased spine areal BMD but less than vBMD. <h3>Conclusions and Relevance</h3> Testosterone treatment for 1 year of older men with low testosterone significantly increased vBMD and estimated bone strength, more in trabecular than peripheral bone and more in the spine than hip. A larger, longer trial could determine whether this treatment also reduces fracture risk. <h3>Trial Registration</h3> clinicaltrials.gov Identifier: NCT00799617
Abstract P6-01-07: Mitochondria-nuclear communication regulates epithelial-mesenchymal transition and metastasis in triple negative breast cancer
Authors: JH Park, KH Jung, T Sirupangi, S Vithayathil, F Jin, V Putluri, DWB Piyarathna, P Yotnda, VB Bhat, A Sreekumar, MT Lewis, C Coarfa, N Putluri, CJ Creighton, L-JC Wong, BA Kaipparettu
Journal: Cancer Research (2017)

Abstract For triple negative breast cancer (TNBC), the driver pathways are still poorly understood. Advances in cancer metabolism research over the last decade have enhanced and modified our understanding on Warburg effect. It is now known that mitochondria in tumors are not always defective in their ability to carry out oxidative phosphorylation. Instead, in proliferating cells, mitochondrial energy pathways are reprogrammed to meet the challenges of macromolecular synthesis and to escape from apoptosis. Tumor initiating cells (TICs) maintain cancer stem cell properties and are known to play significant role in TNBC metastasis. Mitochondrial retrograde regulation (MRR) is a bidirectional communication between mitochondria and nucleus. MRR is triggered by mitochondrial functional demands and it responds in a continuous manner to change metabolic needs of the cell. Using transmitochondrial cybrid (cybrid) technology, we generated different cybrid models under common nuclear backgrounds of benign breast epithelium or TNBC. Mitochondria from cells with different cancer potential such as benign breast epithelium, moderately metastatic and highly metastatic breast cancer cell lines were studied under the common nuclear background to understand MRR-regulated TIC properties and cancer pathways. Using genomic, metabolomic, and proteomic approaches, we confirmed the significance of mitochondrial character in the regulation of epithelial mesenchymal transition (EMT), TIC and metastatic properties. Altogether, our results suggest that MRR is critical in TNBC TIC character and stemness. Citation Format: Park JH, Jung KH, Sirupangi T, Vithayathil S, Jin F, Putluri V, Piyarathna DWB, Yotnda P, Bhat VB, Sreekumar A, Lewis MT, Coarfa C, Putluri N, Creighton CJ, Wong L-JC, Kaipparettu BA. Mitochondria-nuclear communication regulates epithelial-mesenchymal transition and metastasis in triple negative breast cancer [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P6-01-07.
African Americans and Caucasians with Myeloma Have Similar Outcomes in the Current Era: A Tumor Registry Study.
Authors: Brian McClune, Birendra Kumar, Francis Buadi, Robin Womeodu, Kathy Wright, Reed Baskin, Sohail Minhas, Thomas W. Ratliff, Kathleen Spiers, Furhan Yunus, Donna Przepiorka
Journal: Blood (2004)
PP64. CD15S/CD62E HETEROPHILIC INTERACTION MEDIATES ADHESION OF NON-SMALL CELL LUNG CANCER CELLS TO BRAIN ENDOTHELIUM IN LUNG-BRAIN METASTASIS
Authors: Prof Geoff Pilkington, Ms Samah Jassam, Dr Zaynah Maherally, Dr James Smith, Dr Helen Fillmore
Journal: Neuro-Oncology (2017)

INTRODUCTION: More than 50% of patients with lung cancer, including non-small cell lung cancer (NSCLC), will develop brain metastasis which ultimately results in a dismal prognosis. While there are several key steps in the metastastic process, we have focused on the stage where circulating cancer cells adhere to brain endothelium and extravasate through the Blood Brain Barrier (BBB). Sialyl Lewis x, also known as CD15s, is a cell adhesion molecule which is involved in lymphocyte homing and is overexpressed in non-central nervous system cancers. The purpose of our study was to investigate and characterise the interaction of CD15s and TNF-α induced CD62E (E-selectin) in brain metastatic lung cancer cells and brain derived endothelial cells. METHODS: Expression of CD62E and CD15s were evaluated in brain microvascular endothelial cells (hCMEC/D3), primary (A549 and COR-L105) and metastatic NSCLC cells (NCI-H1299, SEBTA-001 and SEBTA-005) using flow cytometry (FC), immunocytochemistry (ICC), immunohistochemistry (IHC) and Western blotting (WB). Qualitative and quantitative adhesion assays adhesion assays under static and physiological flow at shear stress 2.5 dyn/cm2 and volumetric flow rate 10mL/hr were conducted. Immunoblocking of CD15s was performed to investigate its role in adhesion on hCMEC/D3. RESULTS: While CD15s expression on brain endothelial cells was low, CD15s protein expression was detected on primary NSCLC cells, the highest CD15s expression was observed on metastatic NSCLC cells (P<0.001). CD62E expression was observed on hCMEC/D3 cells activated with TNF-α, with lower levels on metastatic NSCLC followed by primary NSCLC cells. Both CD15s and CD62E expression were detected in tissue sections of lung metastatic brain biopsies. Metastatic NSCLC adhered most strongly to hCMEC/D3 compared to primary NSCLC cells. CD15s immunoblocking decreased cancer cell adhesion to brain endothelium under static and shear stress conditions (p<0.001). CONCLUSIONS: This study provides information on the role of CD15s in adhesion of NSCLC cells to brain derived endothelial cells. Our findings suggest that CD15s is involved in the increase in adhesion of circulating lung cancer cells to endothelial cells. Our findings suggests CD15s plays a crucial role in adhesion in concert with TNF-α activation and its binding partner CD62E.