tbuckley/cabot-search huggingface dataset:
M3ムスカリン受容体シグナル伝達はトランスフェクション細胞において熱ショック因子1のりん酸化を介して新規変異ヒトEther‐a‐Go‐Go関連遺伝子チャンネル蛋白質を安定化させる
Authors: Mahati Endang, Li Peili, Kurata Yasutaka, Maharani Nani, Ikeda Nobuhito, Sakata Shinji, Ogura Kazuyoshi, Miake Junichiro, Aiba Takeshi, Shimizu Wataru, Nakasone Naoe, Ninomiya Haruaki, Higaki Katsumi, Yamamoto Kazuhiro, Nakai Akira, Shirayoshi Yasuaki, Hisatome Ichiro
Journal: Circulation (2016)
Variation in dermoscopic features of basal cell carcinoma as a function of anatomical location and pigmentation status
Authors: Z.J. Wolner, S. Bajaj, E. Flores, C. Carrera, C. Navarrete-Dechent, S.W. Dusza, H.S. Rabinovitz, M.A. Marchetti, A.A. Marghoob
Journal: British Journal of Dermatology (2017)
Nonoperative Management of Pancreatic Fistula
Authors: Todd H. Baron, Richard A. Kozarek
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Incremental Benefit of Transthoracic Doppler Echocardiography for Predicting Proximal Left Coronary Artery Lesion over Computed Tomography Angiography
Authors: Takahashi Kayo, Saitoh Makoto, Morioka Hiroe, Morofuji Toru, Inaba Shinji, Sumimoto Takumi
Journal: Circulation (2016)
Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis
Authors: Zhongwei Cao, Tinghong Ye, Yue Sun, Gaili Ji, Koji Shido, Yutian Chen, Lin Luo, Feifei Na, Xiaoyan Li, Zhen Huang, Jane L. Ko, Vivek Mittal, Lina Qiao, Chong Chen, Fernando J. Martinez, Shahin Rafii, Bi-Sen Ding
Journal: Science Translational Medicine (2017)

Targeted gene delivery and enzyme inhibition in vascular and perivascular cells promote engraftment of transplanted parenchymal cells for lung and liver repair.
RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense
Authors: Lance W. Peterson, Naomi H. Philip, Alexandra DeLaney, Meghan A. Wynosky-Dolfi, Kendra Asklof, Falon Gray, Ruth Choa, Elisabet Bjanes, Elisabeth L. Buza, Baofeng Hu, Christopher P. Dillon, Douglas R. Green, Scott B. Berger, Peter J. Gough, John Bertin, Igor E. Brodsky
Journal: The Journal of Experimental Medicine (2017)

Many pathogens deliver virulence factors or effectors into host cells in order to evade host defenses and establish infection. Although such effector proteins disrupt critical cellular signaling pathways, they also trigger specific antipathogen responses, a process termed "effector-triggered immunity." The Gram-negative bacterial pathogen Yersinia inactivates critical proteins of the NF-κB and MAPK signaling cascade, thereby blocking inflammatory cytokine production but also inducing apoptosis. Yersinia-induced apoptosis requires the kinase activity of receptor-interacting protein kinase 1 (RIPK1), a key regulator of cell death, NF-κB, and MAPK signaling. Through the targeted disruption of RIPK1 kinase activity, which selectively disrupts RIPK1-dependent cell death, we now reveal that Yersinia-induced apoptosis is critical for host survival, containment of bacteria in granulomas, and control of bacterial burdens in vivo. We demonstrate that this apoptotic response provides a cell-extrinsic signal that promotes optimal innate immune cytokine production and antibacterial defense, demonstrating a novel role for RIPK1 kinase-induced apoptosis in mediating effector-triggered immunity to circumvent pathogen inhibition of immune signaling.
Abstract 10378: Characterization of Changes in Cardiac Structure and Function in Mice Treated With Anthracyclines Using Serial Cardiac Magnetic Resonance Imaging
Authors: Pedro V Staziaki, Hoshang Farhad, Otávio Coelho-Filho, Ravi V Shah, Richard N Mitchell, Raymond Y Kwong, Marielle Scherrer-Crosbie, Udo Hoffmann, Michael Jerosch-Herold, Tomas G Neilan
Journal: Circulation (2015)

Introduction: Anthracyclines are a standard chemotherapeutic agent. However, the anthracyclines are associated with a late reduction in left ventricular ejection fraction (LVEF) and heart failure. Pathologically, anthracycline-induced cardiotoxicity (AIC) is characterized by the development of cardiac edema and fibrosis and cardiac magnetic resonance (CMR) is the gold-standard imaging technique for edema and fibrosis. Hypothesis: We hypothesized that a) cardiac edema and fibrosis would be detected by CMR after anthracyclines and b) edema and fibrosis would provide prognostic information. Methods: We performed a longitudinal CMR and histological study of 45 wild-type mice randomized to doxorubicin (DOX, n=30, 5 mg/kg/week for 5 weeks) or placebo (n=15). Measurements were performed at baseline, 5, 10, and 20 weeks after DOX or placebo. Measures of interest were LVEF, myocardial edema and fibrosis. Edema was assessed by T2 mapping, fibrosis by calculating the extracellular volume (ECV) from pre- and post-contrast T1 measurements. Results: In DOX-treated mice vs. placebo, myocardial edema at 5 weeks was increased (T2 values of 32±4 vs. 21±3 ms, P&lt;0.05, Fig. A), while LVEF was unchanged. At 10 weeks, there was a reduction in LVEF (54±6 vs. 63±5% μL, P&lt;0.05) and an increase in myocardial fibrosis (ECV of 0.34±0.03 vs. 0.27±0.03, P&lt;0.05, Fig. B). There was a correlation between T2 measures and cardiac water weight (r=0.79, P=0.007, Fig. C) and between the ECV and histological myocardial fibrosis (r=0.90, P&lt;0.001; Fig. D). Both the early increase in edema and the sub-acute increase in fibrosis predicted the late DOX-induced mortality (P&lt;0.001, Fig. E and F). Conclusions: Our data suggest that, in mice, CMR can detect the early increase in edema and sub-acute increase in fibrosis after anthracyclines, that an increase in edema precedes a reduction in LVEF, that the increase in edema and fibrosis are linked and both are predictive of late animal mortality.
熱還元グラフェンはニューロン及び星状細胞とin vivo成体嗅球のde novoニューロン形成の許容物質である
Authors: Defterali Cagla, Verdejo Raquel, Peponi Laura, D Martin Eduardo, Martinez-Murillo Ricardo, Lopez-Manchado Miguel Angel, Vicario-Abejon Carlos
Journal: Biomaterials (2016)
Serologic and Anaphylactic Reactions of the Cathepsins of Normal and Neoplastic Tissues
Authors: Mary E. Maver, Morris K. Barrett
Journal: JNCI Journal of the National Cancer Institute (1943)

Journal Article Serologic and Anaphylactic Reactions of the Cathepsins of Normal and Neoplastic Tissues Get access Mary E. Maver, Mary E. Maver senior biochemist Search for other works by this author on: Oxford Academic PubMed Google Scholar Morris K. Barrett Morris K. Barrett research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 1, August 1943, Pages 65–73, https://doi.org/10.1093/jnci/4.1.65 Published: 01 August 1943
Determination of Chi Square for Comparing the Number of Matched Pairs With Its Expectation
Authors: Nathan Mantel, Lyman B. Crittenden
Journal: JNCI Journal of the National Cancer Institute (1961)

Determination of Chi Square for Comparing the Number of Matched Pairs With Its Expectation Nathan Mantel, Nathan Mantel Biometry Branch, National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Lyman B. Crittenden Lyman B. Crittenden Biometry Branch, National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 27, Issue 4, October 1961, Pages 887–892, https://doi.org/10.1093/jnci/27.4.887 Published: 01 October 1961
Overdose Deaths Related to Fentanyl and Its Analogs — Ohio, January–February 2017
Authors: Raminta Daniulaityte, Matthew P. Juhascik, Kraig E. Strayer, Ioana E. Sizemore, Kent E. Harshbarger, Heather M. Antonides, Robert R. Carlson
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Ohio is experiencing unprecedented loss of life caused by unintentional drug overdoses (1), with illicitly manufactured fentanyl (IMF) emerging as a significant threat to public health (2,3). IMF is structurally similar to pharmaceutical fentanyl, but is produced in clandestine laboratories and includes fentanyl analogs that display wide variability in potency (2); variations in chemical composition of these drugs make detection more difficult. During 2010-2015, unintentional drug overdose deaths in Ohio increased 98%, from 1,544 to 3,050.* In Montgomery County (county seat: Dayton), one of the epicenters of the opioid epidemic in the state, unintentional drug overdose deaths increased 40% in 1 year, from 249 in 2015 to 349 in 2016 (estimated unadjusted mortality rate = 57.7 per 100,000) (4). IMFs have not been part of routine toxicology testing at the coroner's offices and other types of medical and criminal justice settings across the country (2,3). Thus, data on IMF test results in the current outbreak have been limited. The Wright State University and the Montgomery County Coroner's Office/Miami Valley Regional Crime Laboratory (MCCO/MVRCL) collaborated on a National Institutes of Health study of fentanyl analogs and metabolites and other drugs identified in 281 unintentional overdose fatalities in 24 Ohio counties during January-February 2017. Approximately 90% of all decedents tested positive for fentanyl, 48% for acryl fentanyl, 31% for furanyl fentanyl, and 8% for carfentanil. Pharmaceutical opioids were identified in 23% of cases, and heroin in 6%, with higher proportions of heroin-related deaths in Appalachian counties. The majority of decedents tested positive for more than one type of fentanyl. Evidence suggests the growing role of IMFs, and the declining presence of heroin and pharmaceutical opioids in unintentional overdose fatalities, compared with 2014-2016 data from Ohio and other states (3-5). There is a need to include testing for IMFs as part of standard toxicology panels for biological specimens used in the medical, substance abuse treatment, and criminal justice settings.
Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy
Authors: A.R. Sánchez-Paulete, A. Teijeira, F.J. Cueto, S. Garasa, J.L. Pérez-Gracia, A. Sánchez-Arráez, D. Sancho, I. Melero
Journal: Annals of Oncology (2017)
IgM受容体FcμRは,IgM BCRの発現を調節することにより持続性BCRシグナル伝達を制限する
Authors: Nguyen Trang T T, Klaesener Kathrin, Zuern Christa, Castillo Petricia A, Brust‐Mascher Ingrid, Imai Denise M, Bevins Charles L, Reardon Colin, Reth Michael, Baumgarth Nicole
Journal: Nature Immunology (2017)
Health-Related Behaviors and Academic Achievement Among High School Students — United States, 2015
Authors: Catherine N. Rasberry, Georgianne F. Tiu, Laura Kann, Tim McManus, Shannon L. Michael, Caitlin L. Merlo, Sarah M. Lee, Michele K. Bohm, Francis Annor, Kathleen A. Ethier
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Studies have shown links between educational outcomes such as letter grades, test scores, or other measures of academic achievement, and health-related behaviors (1-4). However, as reported in a 2013 systematic review, many of these studies have used samples that are not nationally representative, and quite a few studies are now at least 2 decades old (1). To update the relevant data, CDC analyzed results from the 2015 national Youth Risk Behavior Survey (YRBS), a biennial, cross-sectional, school-based survey measuring health-related behaviors among U.S. students in grades 9-12. Analyses assessed relationships between academic achievement (i.e., self-reported letter grades in school) and 30 health-related behaviors (categorized as dietary behaviors, physical activity, sedentary behaviors, substance use, sexual risk behaviors, violence-related behaviors, and suicide-related behaviors) that contribute to leading causes of morbidity and mortality among adolescents in the United States (5). Logistic regression models controlling for sex, race/ethnicity, and grade in school found that students who earned mostly A's, mostly B's, or mostly C's had statistically significantly higher prevalence estimates for most protective health-related behaviors and significantly lower prevalence estimates for most health-related risk behaviors than did students with mostly D's/F's. These findings highlight the link between health-related behaviors and education outcomes, suggesting that education and public health professionals can find their respective education and health improvement goals to be mutually beneficial. Education and public health professionals might benefit from collaborating to achieve both improved education and health outcomes for youths.
Unraveling Vascular Inflammation
Authors: Heather L. Teague, Mark A. Ahlman, Abass Alavi, Denisa D. Wagner, Andrew H. Lichtman, Matthias Nahrendorf, Filip K. Swirski, Frank Nestle, Joel M. Gelfand, Mariana J. Kaplan, Steven Grinspoon, Paul M. Ridker, David E. Newby, Ahmed Tawakol, Zahi A. Fayad, Nehal N. Mehta
Journal: Journal of the American College of Cardiology (2017)
Modeling Major Adverse Outcomes of Pediatric and Adult Patients With Congenital Heart Disease Undergoing Cardiac Catheterization
Authors: Natalie Jayaram, John A. Spertus, Kevin F. Kennedy, Robert Vincent, Gerard R. Martin, Jeptha P. Curtis, David Nykanen, Phillip M. Moore, Lisa Bergersen
Journal: Circulation (2017)

Background: Risk standardization for adverse events after congenital cardiac catheterization is needed to equitably compare patient outcomes among different hospitals as a foundation for quality improvement. The goal of this project was to develop a risk-standardization methodology to adjust for patient characteristics when comparing major adverse outcomes in the NCDR’s (National Cardiovascular Data Registry) IMPACT Registry (Improving Pediatric and Adult Congenital Treatment). Methods: Between January 2011 and March 2014, 39 725 consecutive patients within IMPACT undergoing cardiac catheterization were identified. Given the heterogeneity of interventional procedures for congenital heart disease, new procedure-type risk categories were derived with empirical data and expert opinion, as were markers of hemodynamic vulnerability. A multivariable hierarchical logistic regression model to identify patient and procedural characteristics predictive of a major adverse event or death after cardiac catheterization was derived in 70% of the cohort and validated in the remaining 30%. Results: The rate of major adverse event or death was 7.1% and 7.2% in the derivation and validation cohorts, respectively. Six procedure-type risk categories and 6 independent indicators of hemodynamic vulnerability were identified. The final risk adjustment model included procedure-type risk category, number of hemodynamic vulnerability indicators, renal insufficiency, single-ventricle physiology, and coagulation disorder. The model had good discrimination, with a C-statistic of 0.76 and 0.75 in the derivation and validation cohorts, respectively. Model calibration in the validation cohort was excellent, with a slope of 0.97 (standard error, 0.04; P value [for difference from 1] =0.53) and an intercept of 0.007 (standard error, 0.12; P value [for difference from 0] =0.95). Conclusions: The creation of a validated risk-standardization model for adverse outcomes after congenital cardiac catheterization can support reporting of risk-adjusted outcomes in the IMPACT Registry as a foundation for quality improvement.
ROS関連炎症性腸疾患に対する新しい治療としてキサンチンオキシダーゼ阻害剤の水溶性PEG抱合体,PEG‐AHPPミセル
Authors: Fang Jun, Yin Hongzhuan, Liao Long, Qin Haibo, Ueda Fumiko, Uemura Kyoko, Eguchi Kanami, Y Bharate Gahininath, Maeda Hiroshi
Journal: Journal of Controlled Release (2016)
Synergistic effects of long-wavelength ultraviolet A1 and visible light on pigmentation and erythema
Authors: I. Kohli, S. Chaowattanapanit, T.F. Mohammad, C.L. Nicholson, S. Fatima, G. Jacobsen, N. Kollias, H.W. Lim, I.H. Hamzavi
Journal: British Journal of Dermatology (2017)

Visible light (VL) induces multiple cutaneous effects. Sunscreen testing protocols recommended by regulatory bodies throughout the world require the use of solar simulators with spectral output in the ultraviolet (UV) domain only. However, sunlight contains VL and infrared radiation also.This study aimed to evaluate the contributions of VL and UVA on pigmentation and erythema, and optimize parameters for in vivo testing.Ten subjects with Fitzpatrick skin phototype IV-VI were enrolled. Subjects were irradiated on their back with VL using two light sources: one containing pure VL and one containing VL with less than 0·5% UVA1 (VL+UVA1). Four different irradiances were administered to investigate reciprocity behaviour. Assessments, including photography, Investigator's Global Assessment, colorimetry and spectroscopy, were performed immediately, 24 h, 7 days and 14 days post-irradiation.Pigmentation was observed with both light sources; however, pigment intensity was greater with VL+UVA1 than with pure VL. Reciprocity was observed in pure VL sites, but not VL+UVA1. Variation in spectral output had greater impact on pigment intensity than irradiance. Clinical erythema was observed on the VL+UVA1 side, but not on the pure VL side. A protocol for testing photoprotection product efficacy against VL-induced effects has been proposed.The findings suggest a synergistic relationship between VL and UVA1 and emphasize the need for developing means of photoprotection against VL.
Amplification of toll-like receptor sensitivity by muramyl dipeptide is impaired in crohn's disease associated NOD2 mutations.
Authors: D A van Heel, S Ghosh, M Butler, K A Hunt, A Lundberg, T Ahmad, D P B mcGovern, C Onnie, K Negoro, S Goldthorpe, M J Foxwell, C G Mathew, A Forbes, D P Jewell, R J Playford
Journal: Gut (2005)
New chapter in tackling antimicrobial resistance in Thailand
Authors: Nithima Sumpradit, Suriya Wongkongkathep, Sitanan Poonpolsup, Noppavan Janejai, Wantana Paveenkittiporn, Phairam Boonyarit, Sasi Jaroenpoj, Niyada Kiatying-Angsulee, Wantanee Kalpravidh, Angkana Sommanustweechai, Viroj Tangcharoensathien
Journal: BMJ (2017)

<b>Nithima Sumpradit and colleagues</b> describe the experience of Thailand in developing its national strategic plan on antimicrobial resistance and highlight the need for sustained political commitment and multisectoral collaboration
Nonoperative Management of Pancreatic Fistula—Reply
Authors: F. Jasmijn Smits, Hjalmar C. van Santvoort, I. Quintus Molenaar
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Field‐Effect Biosensors for On‐Site Detection: Recent Advances and Promising Targets
Authors: Jaebin Choi, Tae Wha Seong, Minhong Jeun, Kwan Hyi Lee
Journal: Advanced Healthcare Materials (2017)

Abstract There is an explosive interest in the immediate and cost‐effective analysis of field‐collected biological samples, as many advanced biodetection tools are highly sensitive, yet immobile. On‐site biosensors are portable and convenient sensors that provide detection results at the point of care. They are designed to secure precision in highly ionic and heterogeneous solutions with minimal hardware. Among various methods that are capable of such analysis, field‐effect biosensors are promising candidates due to their unique sensitivity, manufacturing scalability, and integrability with computational circuitry. Recent developments in nanotechnological surface modification show promising results in sensing from blood, serum, and urine. This report gives a particular emphasis on the on‐site efficacy of recently published field‐effect biosensors, specifically, detection limits in physiological solutions, response times, and scalability. The survey of the properties and existing detection methods of four promising biotargets, exosomes, bacteria, viruses, and metabolites, aims at providing a roadmap for future field‐effect and other on‐site biosensors.
Production of Malignancy in Vitro. II. Photomicrographic Equipment
Authors: Earle, Wilton R.
Journal: JNCI Journal of the National Cancer Institute (1943)

Journal Article Production of Malignancy in Vitro. II. Photomicrographic Equipment Get access Wilton R. Earle Wilton R. Earle senior cytologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 2, October 1943, Pages 135–145, https://doi.org/10.1093/jnci/4.2.135 Published: 01 October 1943