tbuckley/cabot-search huggingface dataset:
Une surveillance syndromique basée sur les services d’urgences et la mortalité brute : deux exemples
Authors: L Josseran, Javier Nicolau, N Caillère, P Astagneau, G Brücker
Journal: Eurosurveillance (2006)

Les dernieres crises sanitaires ont montre la necessite de disposer rapidement d’informations permettant aux decideurs une gestion appropriee. Les producteurs de donnees les plus adaptes pour repondre a cette necessite sont les professionnels enregistrant en routine des donnees pour leur activite. Nous decrivons ici l’experimentation menee par l’InVS sur la base de donnees recueillies dans les services d’urgences et les etats civils.
Les donnees des urgences sont enregistrees a partir de services d’urgences informatisees et les donnees de mortalite sont adressees par l’Insee. La transmission de donnees est quotidienne. Les donnees de grippe des epidemies 2004/05 et 2005/06 sont comparees aux donnees du Reseau Sentinelles des memes annees. Les donnees de sante environnementales sont confrontees aux temperatures parisiennes de juin a aout 2006. Une analyse de la mortalite est faite sur une base hebdomadaire. 
La correlation entre les donnees de grippe des urgences et celles de Sentiweb est significative (p l 0,001) pour les deux epidemies. En 2005 et 2006, les epidemies sont decrites de facon quasi identique par les deux sources et le debut de chacune d’elle est identifie par les deux systemes pendant les memes semaines. Pour ce qui est des donnees en lien avec la chaleur, on observe une correlation significative entre certains diagnostics et l’augmentation de la temperature. Pour ces deux types de phenomenes, la mortalite augmente significativement avec une a deux semaines de decalage. 
C’est la premiere fois, a notre connaissance, qu’une experimentation utilisant en temps reel des donnees de morbidite et de mortalite est menee. Ces premiers resultats montrent la complementarite de ces donnees et leurs analyses concomitantes en temps reel permettent de mesurer rapidement l’impact d’un phenomene.
Additional Diagnostic Value of Combined Angio-Computed Tomography and 18F-Fluorodeoxyglucose Positron Emission Tomography in Infectious Aortitis
Authors: Nidaa Mikail, Khadija Benali, Antoine Dossier, Claire Bouleti, Fabien Hyafil, Dominique Le Guludec, François Rouzet, Phalla Ou
Journal: JACC. Cardiovascular imaging (2017)
Evaluación epidemiológica y virológica de la actividad gripal en Europa durante la temporada 2003-2004
Authors: W J Paget, T J Meerhoff, A Meijer
Journal: Eurosurveillance (2005)

En Europa, la temporada gripal 2003-2004 estuvo marcada por la diseminacion de una nueva variante, el virus A/Fujian/411/2002 (H3N2), un poco diferente del componente de la cepa A(H3N2) utilizada en la vacuna antigripal. En Europa se detectaron casos esporadicos a finales de la temporada 2002-2003 y la actividad gripal asociada con este virus ocurrio a comienzos de la temporada 2003-2004. Generalmente, la actividad gripal se manifesto primero en Europa occidental (Irlanda, Reino Unido y peninsula iberica) en los meses de octubre y noviembre, luego se desplazo gradualmente rumbo al este a traves de Europa, afectando a Letonia, Lituania y Polonia en enero y febrero de 2004. En general, la intensidad de la actividad clinica fue superior a la de la temporada 2002-2003 (segun 13 redes de las 20). Ademas, en los paises que declaran datos por grupos de edad, las tasas de consultas mas altas se observaron en ninos de 0 a 14 anos. Sin embargo, pese a la emergencia de esta nueva variante A(H3N2), las incidencias clinicas no aumentaron especialmente, comparadas con los datos historicos. La composicion de la vacuna antigripal 2004-2005 fue modificada comparada con la de la temporada 2003-2004, e incluye una cepa semejante al virus A/Fujian/411/2002 (H3N2) y una nueva cepa de tipo B (B/Shanghai/361/2002).
TCT-229 One-year clinical outcome of biodegradable polymer sirolimus-eluting stent in all-comer population of ULISSE registry (ULtimaster Italian multicentre all-comerS Stent rEgistry)
Authors: Cosmo Godino, Alessandro Beneduce, Carlo Andrea Pivato, Mauro Chiarito, Alberto Cappelletti, Giuseppe Ferrante, Giulia Perfetti, Franco Fabbiocchi, Stefania Falcone, Alfonso Ielasi, Adele Pierri, Valeria Magni, Matteo Montorfano, Stefano De Martini, Rosario Parisi, David Rutigliano, Nicola Locuratolo, Alberto Margonato, Alberto Benassi, Angelo Anzuini, Bernhard Reimers, Maurizio Tespilli, Carlo Briguori, Antonio Bartorelli, Antonio Colombo
Journal: Journal of the American College of Cardiology (2017)
TCT-565 Long-term Outcomes and Predictors Of Adverse Events After Successful Saphenous Vein Graft Intervention. Results from A Large Single-Center
Authors: Serdar Farhan, Usman Baber, Birgit Vogel, Samantha Sartori, Jaya Chandrasekhar, Sabato Sorrentino, Madhav Sharma, Zhen Ge, Hannah Levine, Nitin Barman, Pooja Vijay, Srushti Shah, Jason Kovacic, Pedro Moreno, Gennaro Giustino, Roxana Mehran, Annapoorna Kini, Samin Sharma
Journal: Journal of the American College of Cardiology (2017)
Introducing the new BTS Guideline: Management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)
Authors: Charles S Haworth, R Andres Floto
Journal: Thorax (2017)

The new BTS Guidelines for the management of non-tuberculous mycobacterial pulmonary disease combine the best available evidence with expert consensus to generate a set of pragmatic Guidelines, published as a supplement to this issue of Thorax, to assist in the management of these challenging infections.
Long-term Change in the Risk of Skin Cancer After Organ Transplantation
Authors: Syed Mohammad Husain Rizvi, Bjarte Aagnes, Hallvard Holdaas, Einar Gude, Kristin Muri Boberg, Øystein Bjørtuft, Per Helsing, Torbjørn Leivestad, Bjørn Møller, Petter Gjersvik
Journal: JAMA Dermatology (2017)

The high risk of skin cancer after organ transplantation is a major clinical challenge and well documented, but reports on temporal trends in the risk of posttransplant cutaneous squamous cell carcinoma (SCC) are few and appear contradictory.
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
Authors: Alexander J. Valvezan, Marc Turner, Amine Belaid, Hilaire C. Lam, Spencer K. Miller, Molly C. McNamara, Christian Baglini, Benjamin E. Housden, Norbert Perrimon, David J. Kwiatkowski, John M. Asara, Elizabeth P. Henske, Brendan D. Manning
Journal: Cancer Cell (2017)
Choice of implant combinations in total hip replacement: systematic review and network meta-analysis
Authors: José A López-López, Rachel L Humphriss, Andrew D Beswick, Howard H Z Thom, Linda P Hunt, Amanda Burston, Christopher G Fawsitt, William Hollingworth, Julian P T Higgins, Nicky J Welton, Ashley W Blom, Elsa M R Marques
Journal: BMJ (2017)

<b>Objective</b>&nbsp;To compare the survival of different implant combinations for primary total hip replacement (THR). <b>Design</b>&nbsp;Systematic review and network meta-analysis. <b>Data sources</b>&nbsp;Medline, Embase, The Cochrane Library, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, and the EU Clinical Trials Register. <b>Review methods</b>&nbsp;Published randomised controlled trials comparing different implant combinations. Implant combinations were defined by bearing surface materials (metal-on-polyethylene, ceramic-on-polyethylene, ceramic-on-ceramic, or metal-on-metal), head size (large ≥36 mm or small &lt;36 mm), and fixation technique (cemented, uncemented, hybrid, or reverse hybrid). Our reference implant combination was metal-on-polyethylene (not highly cross linked), small head, and cemented. The primary outcome was revision surgery at 0-2 years and 2-10 years after primary THR. The secondary outcome was the Harris hip score reported by clinicians. <b>Results</b>&nbsp;77 studies were included in the systematic review, and 15 studies (3177 hips) in the network meta-analysis for revision. There was no evidence that the risk of revision surgery was reduced by other implant combinations compared with the reference implant combination. Although estimates are imprecise, metal-on-metal, small head, cemented implants (hazard ratio 4.4, 95% credible interval 1.6 to 16.6) and resurfacing (12.1, 2.1 to 120.3) increase the risk of revision at 0-2 years after primary THR compared with the reference implant combination. Similar results were observed for the 2-10 years period. 31 studies (2888 patients) were included in the analysis of Harris hip score. No implant combination had a better score than the reference implant combination. <b>Conclusions</b>&nbsp;Newer implant combinations were not found to be better than the reference implant combination (metal-on-polyethylene (not highly cross linked), small head, cemented) in terms of risk of revision surgery or Harris hip score. Metal-on-metal, small head, cemented implants and resurfacing increased the risk of revision surgery compared with the reference implant combination. The results were consistent with observational evidence and were replicated in sensitivity analysis but were limited by poor reporting across studies. <b>Systematic review registration</b>&nbsp;PROSPERO CRD42015019435.
Modern-Type Depression as an “Adjustment” Disorder in Japan: The Intersection of Collectivistic Society Encountering an Individualistic Performance-Based System
Authors: Takahiro A. Kato, Shigenobu Kanba
Journal: American Journal of Psychiatry (2017)

Japan has recently seen an increase in cases similar to that of Mr. A, especially among young adults, a syndrome referred to as "modern-type depression" (MTD) (1).Characteristics of MTD include situation-dependent depressive state, blaming others, and strong avoidant tendencies (2, 3).Individuals with MTD display absenteeism from work or school, complaining "Mr.A" is a 35-year-old company employee living with his wife and son.He had no notable developmental problems.His father was a traditional Japanese company employee who was often absent from home because of work.His mother, a stay-at-home mom, had high expectations for Mr. A's academic success and sent him to cram school from an early age.He participated in school sports clubs but spent the majority of his time playing video games.He was never enthusiastic about academics but did relatively well.After high school, he entered a well-known university and started to live alone.He had no specific aspirations in life, but, following others, he applied to some well-known companies.He accepted a job at a company that "happened to" offer him a career-track position.For a few years, he did relatively well under a good mentor who guided him.In his fifth year, he was reassigned to a new division, where he was often required to express his own opinion, which he found difficult.His supervisor scolded him sharply at times, which is not uncommon in Japan but which left Mr. A feeling unhappy and dissatisfied.Having been an A student, this was virtually the first time he had received a stern reprimand.He started experiencing headache, angst, and insomnia, and he frequently arrived late or was absent for work.He himself suspected depression and sought help at a psychosomatic medicine clinic, expressing his wish to take leave from work.His doctor granted a 3-month sick leave for "depressive state."Immediately, Mr. A felt well and would sometimes attend parties with coworkers, which led them to doubt whether he actually had depression.He also complained that his
Compte rendu du sixième Congrès international du Groupe de Travail Européen sur la Diphtérie à Bruxelles, Belgique
Authors: S Lai, A Efstratiou
Journal: Eurosurveillance (2002)

Parallelement a la resurgence de la diphterie observee en Europe de l’est au cours de ces dix dernieres annees, on a pu constater l’apparition d’infections causees par des souches de Corynebacterium diphtheriae non toxinogenes, et par des souches de C. diphtheriae non toxinogenes mais porteuses du gene de la toxine. Ces souches pouvant etre a l’origine d’infections symptomatiques de degres de gravite variables, il convient d’evaluer leur importance clinique et epidemiologique. La presence persistante de souches toxinogenes et non toxinogenes de C. diphtheriae, associee a la variabilite de genotypes et de biotypes, implique la mise en œuvre de nouvelles mesures de vaccination des populations. L’injection de rappel du vaccin reste la methode de protection la plus efficace de la population adulte, groupe de population actuellement le plus expose. La mise en place d’un bon systeme de surveillance, d’une prophylaxie antibiotique efficace et de programmes de vaccination actualises, doit aller de pair avec la poursuite des etudes serologiques qui permettent de surveiller le statut immunitaire de la population.
TCT-166 2-Year Natural History of Lower Limbs in Patients With End-stage Renal Disease on Hemodialysis Due to Diabetic Nephropathy; From PREDICT Study
Authors: Tamon Kato, Yusuke Miyashita, Takashi Miura, Souitirou Ebisawa, Tatsuya Saigusa, Koichiro Kuwahara
Journal: Journal of the American College of Cardiology (2017)
Staphylococcus aureus e MRSA nos hospitais austríacos, 1995
Authors: W Koller
Journal: Eurosurveillance (1997)

En 1996, el Ministerio Federal Austriaco de Sanidad y de Proteccion de consumidores solicito a 327 hospitales de enfermos agudos y a otras instituciones sanitarias que notificaran el numero de pacientes hospitalizados en 1995 que hubieran presentado un cultivo positivo de Staphylococcus aureus (SA). Tambien solicito la proporcion de SA resistentes a la meticilina (MRSA) y de EMRSA (MRSA epidemico caracterizado por su resistencia particular a multiples antibioticos*), al igual que la descripcion de los lugares en los que se habian aislado las cepas.
TCT-6 The optimal timing for staged non-culprit vessel intervention following primary percutaneous coronary intervention for patients with ST-elevation myocardial infarction and multivessel disease: insights from the British Columbia Cardiac Registry using decision analytical methods
Authors: Peter Moore, Navin Chandra, Imad Nadra, Simon Robinson, Eric Fretz, Lilian Ding, Sean Hardiman, Anthony Fung, Eve Aymong, Albert Chan, Steven Hodge, David Wood, Anthony Della Siega, Bilal Iqbal
Journal: Journal of the American College of Cardiology (2017)
TCT-41 Initial Pre-clinical Porcine and Ex-Vivo Human Coronary Images with a Hybrid Intravascular Ultrasound and Optical Coherence Tomography System
Authors: Brian Courtney, Brian Li, Natasha Alves-Kotzev, Mark Harduar, M. Saleem, Jill Weyers, Angela Kim, Amandeep Thind, Jagdish Butany
Journal: Journal of the American College of Cardiology (2017)
TCT-299 Impact of Complete Revascularization on Long-term Clinical Outcomes in Chronic Total Occlusion Patients with Multi-vessel Disease
Authors: Ji Bak Kim, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Won Young Jang, Woo Hyeun Kim, Eun Jin Park, Ja Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2017)
TCTAP A-155 Clinical Impact of Periprocedural Myocardial Infarction According to Various Definitions in Patients Underwent Percutaneous Coronary Intervention with Drug-eluting Stent.
Authors: Yong-Hoon Yoon, Sang Yong Om, Minsoo Kim, Hanbit Park, Sang-Cheol Cho, Osung Kwon, Kyusup Lee, Do-Yoon Kang, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2018)
Conjonctivite épidémique en Allemagne, 2004
Authors: A Schrauder, D Altmann, G Laude, H Claus, K Wegner, R Köhler, H Habicht-Thomas, G Krause
Journal: Eurosurveillance (2006)

La conjonctivite epidemique peut etre liee a des pathogenes viraux ou bacteriens, alors que la keratoconjonctivite est essentiellement due a des adenovirus de type 8, 19 et 37. En Allemagne, l’incidence des cas de conjonctivite a adenovirus a augmente de 0,2 pour 100 000 habitants (en 2001 et 2002) a 0,5 en 2003 et 0,8 en 2004. 
La presence d’adenovirus detectee dans les prelevements conjonctivaux est a notification obligatoire aupres des services locaux de sante publique. Les donnees sur les cas avec des prelevements conjonctivaux positifs sont ensuite transmises a l’institut Robert-Koch. Ces donnees sont soumises a un controle de qualite et les donnees nationales de surveillance des cas confirmes de conjonctivite a adenovirus sont publiees. 
De janvier a avril 2004, le systeme national de surveillance a detecte une epidemie de 1024 cas (dont 131 confirmes par laboratoire). L’analyse des donnees nationales de surveillance ont montre qu’en mars 2004, la keratoconjonctivite epidemique a d’abord touche des hommes de 18-29 ans, suivi par un nombre croissant de cas chez des femmes du meme groupe d’âge. Parallelement, une epidemie de conjonctivite a sevi au sein des Forces armees allemandes, touchant 6 378 soldats, quasiment exclusivement sans confirmation microbiologique. 
En depit du nombre restreint de cas confirmes par laboratoire, il est ressorti clairement de l’analyse des donnees nationales de surveillance qu’une transmission de personne a personne avait eu lieu entre les jeunes hommes et des personnes du meme groupe d’âge dans la population. Que l’epidemie ait commence dans les garnisons des Forces armees allemandes ou qu’elle aie pu se declencher dans ses locaux, le besoin d’une collaboration entre institutions nationales et militaires de sante publique dans le but de rediger des recommandations pour les challenges a venir se fait clairement sentir.
Prevalence of Untreated Surgical Conditions in Rural Rwanda
Authors: Rebecca G. Maine, Allison F. Linden, Robert Riviello, Emmanuel Kamanzi, Gita N. Mody, Georges Ntakiyiruta, Grace Kansayisa, Edmond Ntaganda, Francine Niyonkuru, Joel M. Mubiligi, Tharcisse Mpunga, John G. Meara, Bethany L. Hedt-Gauthier
Journal: JAMA Surgery (2017)

In low- and middle-income countries, community-level surgical epidemiology is largely undefined. Accurate community-level surgical epidemiology is necessary for surgical health systems planning.To determine the prevalence of surgical conditions in Burera District, Northern Province, Rwanda.A cross-sectional study with a 2-stage cluster sample design (at village and household level) was carried out in Burera District in March and May 2012. A team of surgeons randomly sampled 30 villages with probability proportionate to village population size, then sampled 23 households within each village. All available household members were examined.The presence of 10 index surgical conditions (injuries/wounds, hernias/hydroceles, breast masses, neck masses, obstetric fistulas, undescended testes, hypospadias, hydrocephalus, cleft lip/palate, and clubfoot) was determined by physical examination. Prevalence was estimated overall and for each condition. Multivariable logistic regression was performed to identify factors associated with surgical conditions, accounting for the complex survey design.Of the 2165 examined individuals, 1215 (56.2%) were female. The prevalence of any surgical condition among all examined individuals was 12% (95% CI, 9.2-14.9%). Half of conditions were hernias/hydroceles (49.6%), and 44% were injuries/wounds. In multivariable analysis, children 5 years or younger had twice the odds of having a surgical condition compared with married individuals 21 to 35 years of age (reference group) (odds ratio [OR], 2.2; 95% CI, 1.26-4.04; P = .01). The oldest group, people older than 50 years, also had twice the odds of having a surgical condition compared with the reference group (married, aged >50 years: OR, 2.3; 95% CI, 1.28-4.23; P = .01; unmarried, aged >50 years: OR, 2.38; 95% CI, 1.02-5.52; P = .06). Unmarried individuals 21 to 35 years of age and unmarried individuals aged 36 to 50 years had higher odds of a surgical condition compared with the reference group (aged 21-35 years: OR, 1.68; 95% CI, 0.74-3.82; P = .22; aged 36-50 years: OR, 3.35; 95% CI, 1.29-9.11; P = .02). There was no statistical difference in odds by sex, wealth, education, or travel time to the nearest hospital.The prevalence of surgically treatable conditions in northern Rwanda was considerably higher than previously estimated modeling and surveys in comparable low- and middle-income countries. This surgical backlog must be addressed in health system plans to increase surgical infrastructure and workforce in rural Africa.
TCT-355 Lens opacities prevalence in interventional cardiologists and professional working in the area of hemodynamics in Latin America
Authors: Adriano Barbosa, Regina Medeiros, Adriana Corpa, Fabiana Higa, Marco Tulio Souza, Jorge Luis Vivar Sanchez, Patrícia Barbosa, Antônio Moreira, Alexandre Schaan Quadros, Viviana Lemke, Marcelo Cantarelli
Journal: Journal of the American College of Cardiology (2017)
TCT-160 Valve-in-Valve Transcatheter Aortic Implantation in Degenerative Sutureless Bioprostheses
Authors: Uri Landes, Danny Dvir, Wolfgang Schoels, Christophe Tron, Stephan Ensminger, Matheus Simonato dos Santos, Ulrich Schäfer, Matjaz Bunc, Gabriel Aldea, Alfredo Cerillo, Stephan Windecker, Martin Andreas, John Webb, Ran Kornowski
Journal: Journal of the American College of Cardiology (2017)
Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases
Authors: Zhi Dong Zhou, Eng-King Tan
Journal: Molecular Neurodegeneration (2017)

The homeostasis of iron is vital to human health, and iron dyshomeostasis can lead to various disorders. Iron homeostasis is maintained by iron regulatory proteins (IRP1 and IRP2) and the iron-responsive element (IRE) signaling pathway. IRPs can bind to RNA stem-loops containing an IRE in the untranslated region (UTR) to manipulate translation of target mRNA. However, iron can bind to IRPs, leading to the dissociation of IRPs from the IRE and altered translation of target transcripts. Recently an IRE is found in the 5′-UTR of amyloid precursor protein (APP) and α-synuclein (α-Syn) transcripts. The levels of α-Syn, APP and amyloid β-peptide (Aβ) as well as protein aggregation can be down-regulated by IRPs but are up-regulated in the presence of iron accumulation. Therefore, inhibition of the IRE-modulated expression of APP and α-Syn or chelation of iron in patient's brains has therapeutic significance to human neurodegenerative diseases. Currently, new pre-drug IRE inhibitors with therapeutic effects have been identified and are at different stages of clinical trials for human neurodegenerative diseases. Although some promising drug candidates of chemical IRE inhibitors and iron-chelating agents have been identified and are being validated in clinical trials for neurodegenerative diseases, future studies are expected to further establish the clinical efficacy and safety of IRE inhibitors and iron-chelating agents in patients with neurodegenerative diseases.