tbuckley/cabot-search huggingface dataset:
Adriamycin and ifosfamide-based regimen as induction chemotherapy in desmoplastic small round cell tumors: Results of a retrospective single-center study on 34 patients
Authors: T.S. Assi, A. Le Cesne, E. Nassif, A. Cavalcanti, M. Faron, T. Ibrahim, C. Le Pechoux, O. Mir, J. Adam, S. Dumont, P. Terrier, C. Honore
Journal: Annals of Oncology (2018)

Background: Desmoplastic small round cell tumours (DSRCT) is a rare disease affecting predominantly children and young adults characterised by a specific translocation t(11:22)(p13;q12) which fuses the ESWR1 gene to the WT1 gene. DSRCT shares characteristics with other small-round blue cell cancers including Ewing's sarcoma. . The best induction chemotherapy (IC) is not yet defined. The aim of this study is to evaluate the role of Adriamycin and Ifosfamide (AI)-based regimen as IC in DSRCT. Methods: All pts diagnosed in our tertiary care center with DSRCT treated with AI-based regimen as IC between 1991 and 2017 were included in this study. Demographic, clinical and long-term characteristics were obtained from the electronic medical records and retrospectively analyzed. Results: 34 pts were identified. With a median age of 25 yrs (range 18-56), 25 pts were male (74%). All pts had PS 0-1. 28 pts had symptoms (82%) with pain being the most common (n = 25). 14 pts (41%) had extra-peritoneal metastases (EPM) at diagnosis (liver mets (n = 14) associated with lung mets in 4 pts). Out of 34 pts, 26 pts (77%) received AI as IC. The remaining 8 pts had AI in combination to platinum agents (n = 4) or Etoposide (n = 4). Median number of cycles was 6±1 (range 3-9). Objective response and disease control rates were 71% and 91% respectively. Only 3 pts had progressive disease (PD) (9%). Dose reduction were noted in 2 pts with no treatment discontinuation. 41% had grade 3-4 toxicities. 7 pts (21%) developed febrile neutropenia. 17 pts (50%) underwent surgery (including 2 with EPM). Post-operative chemotherapy was given in 41 pts and radiotherapy in 21 pts. In pts who had surgery, local recurrence free survival was 10 months (95% CI: 7-12) while EPM-free survival was 13 months (95% CI: 7-19). Overall survival (OS) for pts without PD was 25.7 months (95% CI: 20.1-31.3). In pts who had surgery, OS was 28.3 months (95% CI: 13.6-43.1) while those who did not have surgery had an OS of 18.9 months (95% CI: 11.6-26.1). Conclusions: AI-based regimen is a well-tolerated and active option with good response rate as an IC in DSRCT. Comparative data with currently used Ewing-type regimen are eagerly needed in the future. Legal entity responsible for the study: Institut Gustave Roussy. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
GW29-e1382 Association Between Various Glycemic Markers and the Prevalence of Diffuse Coronary Artery Lesion and adverse prognosis in NSTE-ACS patients with Diabetes Mellitus
Authors: Qi Zhao, Tingyu Zhang, Ji Huang, Yue Ma, Xuejian Hou, Zhizhong Li
Journal: Journal of the American College of Cardiology (2018)
Wrist ultrasound - the model method for grey-scale and power Doppler scoring
Authors: Nirupam Purkayastha, Frances Humby, Vidalba Rocher-Ros, Costantino Pitzalis, Stephen Kelly
Journal: Annals of the Rheumatic Diseases (2018)

The use of ultrasound (US) has been at the forefront of aiding diagnosis of inflammatory arthritis since its introduction. More recently, US imaging in patients with clinical remission appears to provide prognostic information with respect to disease flares and progression.1 2 Ultrasonographic scoring typically uses a semiquantitative scale of 0–3 for synovial hypertrophy (SH) and power Doppler (PD). This system works very well in smaller joints or those with single articulations. However, in complex joints such as the wrist with many articulations, the final grading can be difficult. Figure 1A illustrates three potential positions used to score wrist synovitis. As a consequence, there are a number of possible permutations for the wrist US score.



Figure 1 
(A) Illustration of wrist US probe positions and corresponding US images, used for US wrist assessment. (B) Fisher’s exact statistical testing for association between high and low SH/PD groups compared with high and low Krenn synovitis scores. The high US SH score is denoted by …
HGCSG 1403: phase I trial of oxaliplatin /irinotecan /S-1 (OX-IRIS) for unresectable pancreatic cancer
Authors: Yasuyuki Kawamoto, Satoshi Yuki, Hideyuki Hayashi, Shintaro Nakano, Kentaro Sawada, Tetsuhito Muranaka, Hiroshi Nakatsumi, Takuro Saiki, Atsushi Ishiguro, Kazuaki Harada, Yoshimitsu Kobayashi, Ichiro Iwanaga, Kazuteru Hatanaka, Yuh Sakata, Naoya Sakamoto, Yoshito Komatsu
Journal: Annals of Oncology (2018)
Getting to Zero HIV Among Youth
Authors: Mary Jane Rotheram-Borus, Sung-Jae Lee, Dallas Swendeman
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Plasma miR-371a-3p for detection of non-teratomatous viable germ cell tumor in testicular cancer
Authors: L. Nappi, M. Thi, B.J. Eigl, A. Lum, D. Huntsman, C. Martin, B.O. Neil, D.J. Khalaf, K.N. Chi, M.E. Gleave, A. So, P. Black, S. Daneshmand, C.R. Nichols, C.K. Kollmannsberger
Journal: Annals of Oncology (2018)
ATR inhibition with radiation creates an inflammatory tumour microenvironment
Authors: M.T. Dillon, K. Bergerhoff, M. Pedersen, H. Whittock, E. Patin, H. Smith, J. Paget, R. Patel, G. Bozhanova, S. Foo, J. Campbell, C. Ragulan, E. Fontana, A. Wilkins, A. Sadanandam, A. Melcher, M. McLaughlin, K.J. Harrington
Journal: Annals of Oncology (2018)
Medical and dental cooperation using VPN with IPsec in the hospital without dentists
Authors: Kenji Ina, Ryuichi Furuta, Satoshi Kayukawa, Miki Iwasaki, Yuko Sirokawa, Chiaki Koga, Satoshi Hibi, Megumi Kabeya, Shuu Yuasa, Yuko Tomomatsu, Takae Kataoka
Journal: Annals of Oncology (2018)
Community Water Fluoridation and Urinary Fluoride Concentrations in a National Sample of Pregnant Women in Canada
Authors: Christine Till, Rivka Green, John G. Grundy, Richard Hornung, Raichel Neufeld, E. Angeles Martinez-Mier, Pierre Ayotte, Gina Muckle, Bruce Lanphear
Journal: Environmental Health Perspectives (2018)

Background: Fluoride exposures have not been established for pregnant women who live in regions with and without community water fluoridation. Objective: Our aim was to measure urinary fluoride levels during pregnancy. We also assessed the contribution of drinking-water and tea consumption habits to maternal urinary fluoride (MUF) concentrations and evaluated the impact of various dilution correction standards, including adjustment for urinary creatinine and specific gravity (SG). Methods: We measured MUF concentrations in spot samples collected in each trimester of pregnancy from 1,566 pregnant women in the Maternal–Infant Research on Environmental Chemicals cohort. We calculated intraclass correlation coefficients (ICCs) to assess variability in MUF concentrations across pregnancy. We used regression analyses to estimate associations between MUF levels, tea consumption, and water fluoride concentrations as measured by water treatment plants. Results: Creatinine-adjusted MUF values (mean±SD; milligrams per liter) were almost two times higher for pregnant women living in fluoridated regions (0.87±0.50) compared with nonfluoridated regions (0.46±0.34; p&lt;0.001). MUF values tended to increase over the course of pregnancy using both unadjusted values and adjusted values. Reproducibility of the unadjusted and adjusted MUF values was modest (ICC range=0.37–0.40). The municipal water fluoride level was positively associated with creatinine-adjusted MUF (B=0.52, 95% CI: 0.46, 0.57), accounting for 24% of the variance after controlling for covariates. Higher MUF concentrations correlated with numbers of cups of black (r=0.31–0.32 but not green tea (r=0.04–0.06). Urinary creatinine and SG correction methods were highly correlated (r=0.91) and were interchangeable in models examining predictors of MUF. Conclusion: Community water fluoridation is a major source of fluoride exposure for pregnant women living in Canada. Urinary dilution correction with creatinine and SG were shown to be interchangeable for our sample of pregnant women. https://doi.org/10.1289/EHP3546
Abstract P091: The Association of Socioeconomic Status and Subclinical Atherosclerosis in a Rural Bangladesh Population
Authors: Michael Garshick, Fen Wu, Alauddin Ahmed, Golam Sarwar, Yu Chen
Journal: Circulation (2017)

Background: Cardiovascular mortality has risen 30 fold in South Asia yet there is little data on how socioeconomic status (SES) contributes to the rising cardiovascular disease (CVD) burden. In Bangladesh, CVD accounts for the majority of non-communicable mortality. The purpose of this study was to determine the role of SES on subclinical atherosclerosis measured as carotid intima media thickness (cIMT) in a rural Bangladesh population. Methods: cIMT was measured in 1022 participants (average age 46, 40% male) randomly selected from the Health Effects of Arsenic Longitudinal Study (HEALS), a population-based prospective cohort study based in rural Bangladesh. SES was measured with survey data as occupation type, land ownership, educational attainment, and television ownership. We assessed the association between each of these SES indicators and cIMT adjusting for potential confounders. Results: Over half of the participants received formal education (53%) and under half owned land (48%) and a television (44%). Women were primarily homemakers (95%) and men worked as factory workers (24%), laborers (18%), or in business (55%). In univariate analysis, those owning greater than one acre of land (p = 0.03), owning a television (p =0.02), or laborers and business owners when compared to factory workers had higher levels of cIMT (p&lt;0.01). Educational attainment was not an independent predictor of cIMT (p = 0.7). In multivariate analysis after adjustment for potential confounders, men employed in the business sector had a 26.7 μm (95% CI 6.7 - 46.9, p &lt; 0.01) significantly greater level of cIMT when compared to factory workers. The association was strongest in older men (50.8 μm, 95% CI 9.0 - 92.6, ≥50 years old compared to younger men (19.4 μm, 95% CI -2.0 - 40.9, &lt;50 years old). Other SES indicators were not predictors of cIMT after multivariate adjustment. Conclusion: Working in the business sector was positively associated with subclinical atherosclerosis after adjustment for confounders. This finding is consistent with evidence from other developing nations suggesting that certain SES factors are independent predictors of CVD.
Prognostic factors of clear renal cell carcinoma in pT1a cases
Authors: T. Nishikimi, T. Tsuzuki, T. Fujita, N. Sassa, H. Araki, A. Fukatsu, S. Katsuno, Y. Yoshino, R. Hattori, M. Gotoh
Journal: Journal of Clinical Oncology (2009)

e16064 Background: The proportion of clear cell renal cell carcinoma (CRCC) cases diagnosed at pT1a is known to be increasing significantly. Although their prognosis is excellent in general, some cases show distant metastasis. Most of proposed prognostic factors are based on mainly large sized CRCC data. The prognostic factors for small sized CRCC, especially for pT1a cases, aren't well described. Methods: Three hundred three pT1a CRCC cases were retrieved from authors’ institution files. All cases were reviewed by the single uropathologist (T. Tsuzuki). For each case, the following pathological parameters were analyzed: patient age, tumor location (upper, middle, low), Furhman grade, presence of capsule, presence of lympho-vascular invasion, growth pattern (expansive or infiltrating), presence of scar, presence of hemorrhage, and presence of necrosis. Results: Male to female ratio was 4.4. Patient's age ranged from 21 to 85 years (median: 59 years). Follow up duration ranged from one to 225 months (median: 59 months). 35 cases showed distant metastasis. The 5-year and 10-year cause specific survival rate were 96.9%, 93.0%. The 5-year and 10-year recurrence free survival rate were 91.8%, 83.9%. Furhman grade (grade 1+2+3 vs. 4), presence of lympho-vascular invasion, infiltrating growth pattern, and presence of necrosis were statistical significant (p &lt; 0.0001). Conclusions: Furhman grade (less than 3 vs. 4), presence of lympho-vascular invasion, growth pattern, and presence of necrosis can be prognostic factors in CRCC in pTa cases. Growth pattern, which is unrecognized concept for prognosis, can be a new prognostic factor in CRCC. No significant financial relationships to disclose.
US opioids: Congress passes bill to tackle epidemic but provides little new funding
Authors: Owen Dyer
Journal: BMJ (2018)

The US president, Donald Trump, is expected to sign legislation to tackle the opioid epidemic this week, after it passed both houses of Congress with large bipartisan majorities.

The 660 page SUPPORT for Patients and Communities Act1 makes many policy changes long sought by clinicians. But it falls some way short of funding the broad expansion in addiction treatment that many experts say is needed to stem the crisis.

The bill passed the House by 393-8 votes and the Senate by 98-1. Senator Lamar Alexander, a Tennessee Republican who was the bill’s lead sponsor, said that, despite Democrats’ and Republicans’ contentious disagreement on other subjects, “we have an urgent, bipartisan consensus, a virtually unanimous agreement, to deal with the most urgent public health epidemic facing our country today.”

But several …
Abstract 12945: Correlation Between Left Atrial Epicardial Adipose Tissue Volume and Acute Effects of Colchicine Treatment after Atrial Fibrillation Ablation
Authors: Yasuyuki Egami, Masami Nishino, Jun Tanouchi
Journal: Circulation (2013)

Background: It has reported that epicardial adipose tissue (EAT) activated pro-inflammatory cytokines and EAT was associated with the development of atrial fibrillation (AF). Immediate recurrence o...
Predictive value of in-vitro testing anti-cancer therapy sensitivity on 3D micro-tumors (tumoroids) from patients with metastatic colorectal cancer: A feasibility study
Authors: L.H. Jensen, C. Dam, G. Hagel, C. Hansen, H. Harling, B.M. Havelund, A. Jakobsen, J. Lindebjerg, S. Rafaelsen, O. Thastrup, T.F. Hansen
Journal: Annals of Oncology (2018)
Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings
Authors: Jenna Tucker, Tessa Fischer, Laurence Upjohn, David Mazzera, Madhur Kumar
Journal: JAMA Network Open (2018)

Over half of adults in the United States report consuming dietary supplements. The US Food and Drug Administration (FDA) has warned of numerous dietary supplements containing undeclared, unapproved pharmaceutical ingredients. These FDA warnings have not been comprehensively analyzed for recent years.To summarize trends across adulterated (containing unapproved ingredients) dietary supplements associated with a warning released by the FDA from 2007 through 2016.In this quality improvement study, data were extracted from the FDA's Center for Drug Evaluation and Research, Tainted Products Marketed as Dietary Supplements_CDER database from 2007 through 2016. Data from each warning were recorded unless multiple warnings were issued for the same product within a 6-month period. Date, product name, company, hidden ingredient(s), product category, source of sample, and warning document type were recorded for each included warning. Data analysis was conducted from February 2017 to June 2017.From 2007 through 2016, 776 adulterated dietary supplements were identified by the FDA and 146 different dietary supplement companies were implicated. Most of these products were marketed for sexual enhancement (353 [45.5%]), weight loss (317 [40.9%]), or muscle building (92 [11.9%]), with 157 adulterated products (20.2%) containing more than 1 unapproved ingredient. The most common adulterants were sildenafil for sexual enhancement supplements (166 of 353 [47.0%]), sibutramine for weight loss supplements (269 of 317 [84.9%]), and synthetic steroids or steroid-like ingredients for muscle building supplements (82 of 92 [89.1%]). There were 28 products named in 2 or 3 warnings more than 6 months apart. Of these products, 19 (67.9%) were reported to contain new unapproved ingredients in the second or third warning, consistent with the assumption that the FDA found the product to be adulterated more than once. In recent years (2014-2016), 117 of 303 adulterated samples (38.6%) were identified through online sampling and 104 of 303 (34.3%) were identified through the examination of international mail shipments.Active pharmaceuticals continue to be identified in dietary supplements, especially those marketed for sexual enhancement or weight loss, even after FDA warnings. The drug ingredients in these dietary supplements have the potential to cause serious adverse health effects owing to accidental misuse, overuse, or interaction with other medications, underlying health conditions, or other pharmaceuticals within the supplement.
Macrophage-specific MHCII expression is regulated by a remote <i>Ciita</i> enhancer controlled by NFAT5
Authors: Maria Buxadé, Hector Huerga Encabo, Marta Riera-Borrull, Lucía Quintana-Gallardo, Pilar López-Cotarelo, Mónica Tellechea, Sara Martínez-Martínez, Juan Miguel Redondo, Juan Martín-Caballero, Juana María Flores, Elena Bosch, José Luis Rodríguez-Fernández, Jose Aramburu, Cristina López-Rodríguez
Journal: The Journal of Experimental Medicine (2018)

MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses. Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type-specific promoters. Here we show that the transcription factor NFAT5 is needed for expression of Ciita and MHCII in macrophages, but not in dendritic cells and other APCs. NFAT5-deficient macrophages showed defective activation of MHCII-dependent responses in CD4+ T lymphocytes and attenuated capacity to elicit graft rejection in vivo. Ultrasequencing analysis of NFAT5-immunoprecipitated chromatin uncovered an NFAT5-regulated region distally upstream of Ciita This region was required for CIITA and hence MHCII expression, exhibited NFAT5-dependent characteristics of active enhancers such as H3K27 acetylation marks, and required NFAT5 to interact with Ciita myeloid promoter I. Our results uncover an NFAT5-regulated mechanism that maintains CIITA and MHCII expression in macrophages and thus modulates their T lymphocyte priming capacity.
A corticopontine circuit for initiation of urination
Authors: Jiwei Yao, Quanchao Zhang, Xiang Liao, Qianwei Li, Shanshan Liang, Xianping Li, Yalun Zhang, Xiangning Li, Haoyu Wang, Han Qin, Meng Wang, Jingcheng Li, Jianxiong Zhang, Wenjing He, Wen Zhang, Tong Li, Fuqiang Xu, Hui Gong, Hongbo Jia, Xiaohong Xu, Junan Yan, Xiaowei Chen
Journal: Nature Neuroscience (2018)
Population-based use of intravenous bisphosphonates in patients newly diagnosed with symptomatic multiple myeloma in Denmark in 2005-2015: Impact of patient characteristics
Authors: V. Ehrenstein, A.G. Ording, S.P. Ulrichsen, I.T. Andersen, A. Seesaghur, C. Helleberg, T. Silkjær, R. Hernandez, D. Niepel, N. Abildgaard
Journal: Annals of Oncology (2018)
Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course
Authors: Melanie Schirmer, Lee Denson, Hera Vlamakis, Eric A. Franzosa, Sonia Thomas, Nathan M. Gotman, Paul Rufo, Susan S. Baker, Cary Sauer, James Markowitz, Marian Pfefferkorn, Maria Oliva-Hemker, Joel Rosh, Anthony Otley, Brendan Boyle, David Mack, Robert Baldassano, David Keljo, Neal LeLeiko, Melvin Heyman, Anne Griffiths, Ashish S. Patel, Joshua Noe, Subra Kugathasan, Thomas Walters, Curtis Huttenhower, Jeffrey Hyams, Ramnik J. Xavier
Journal: Cell Host & Microbe (2018)
Factors which potentially impact on investigational sites initiation time of oncology clinical trials
Authors: Ayaka Sano, Nobuyuki Shiga, Hiromi Sasamoto, Akihiro Maruhashi, Takanori Tsuda, Naomi Shimada, Hajime Suzuki, Koji Ando, Xinbin Qiu, Yotaro Izumi, Mari Omae, Jotaro Shinagawa
Journal: Annals of Oncology (2018)
Scientific Misconduct and Medical Journals
Authors: Howard Bauchner, Phil B. Fontanarosa, Annette Flanagin, Joe Thornton
Journal: JAMA (2018)

According to the US Department of Health and Human Services, "Research misconduct means fabrication, falsification, or plagiarism in proposing, performing, or reviewing research, or in reporting research results." 1 Other important irregularities involving the biomedical research process include, but are not limited to, ethical issues (eg, failure to obtain informed consent, failure to obtain appropriate approval from an institutional review board, and mistreatment of research participants), issues involving authorship responsibilities and disputes, duplicate publication, and failure to report conflicts of interest.When authors are found to have been involved with research misconduct or other serious irregularities involving articles that have been published in scientific journals, editors have a responsibility to ensure the accuracy and integrity of the scientific record. 2,35][6] During the last 5 years, JAMA and the JAMA Network journals have published 12 notices of Retraction about 15 articles (including recent Retractions of 6 articles by the same author) 7 and 6 notices of Expression of Concern about 9 articles.These notices were published primarily because the original studies were found to involve fabrication or falsification of data that invalidated the research and the published articles; in some cases, postpublication investigations could not provide evidence that the original research was valid.Since 2015, JAMA and the JAMA Network journals also have retracted and replaced 12 articles for instances of inadvertent pervasive error resulting from incorrect data coding or incorrect analyses and without evidence of research misconduct. 8During the same period, 1021 correction notices have been published in these journals.The JAMA Network policies regarding corrections and retraction with replacement have been published previously. 8,9In this Editorial, the focus is on a more complex and challenging issue-scientific misconduct involving fabrication, falsification, and plagiarism in the reporting of research.
GW29-e1807 Cardiac Fibroblast Specific Deletion of SWELL1 Ameliorates Post-Myocardial Infarction Ventricular Remodeling and Dysfunction via Caveolin1/STAT3 Signaling.
Authors: Xiyao Chen, Fuyang Zhang, Ling Tao, Xiaoming Wang
Journal: Journal of the American College of Cardiology (2018)
Ramucirumab as second-line treatment in patients with advanced hepatocellular carcinoma (HCC) and elevated alpha-fetoprotein (AFP) following first-line sorafenib: Patient reported outcome results across two phase III studies (REACH-2 and REACH)
Authors: A.X. Zhu, R.S. Finn, P.R. Galle, J.M. Llovet, J.F. Blanc, T. Okusaka, I. Chau, D. Cella, A. Girvan, J. Gable, L. Bowman, Y. Hsu, P.B. Abada, M. Kudo
Journal: Annals of Oncology (2018)