Bronchial Thermoplasty for Severe Asthmatic Cough
Authors: Yoshihiro Kanemitsu, Osamu Takakuwa, Kensuke Fukumitsu, Takamitsu Asano, Akio Niimi
Journal: Annals of Internal Medicine (2018)

Letters3 July 2018Bronchial Thermoplasty for Severe Asthmatic CoughYoshihiro Kanemitsu, MD, PhD, Osamu Takakuwa, MD, PhD, Kensuke Fukumitsu, MD, PhD, Takamitsu Asano, MD, PhD, and Akio Niimi, MD, PhDYoshihiro Kanemitsu, MD, PhDNagoya City University, Nagoya, Japan (Y.K., O.T., K.F., T.A., A.N.), Osamu Takakuwa, MD, PhDNagoya City University, Nagoya, Japan (Y.K., O.T., K.F., T.A., A.N.), Kensuke Fukumitsu, MD, PhDNagoya City University, Nagoya, Japan (Y.K., O.T., K.F., T.A., A.N.), Takamitsu Asano, MD, PhDNagoya City University, Nagoya, Japan (Y.K., O.T., K.F., T.A., A.N.), and Akio Niimi, MD, PhDNagoya City University, Nagoya, Japan (Y.K., O.T., K.F., T.A., A.N.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0748 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Bronchial thermoplasty is a novel treatment for severe asthma that reduces the volume of airway smooth muscles and the number of airway nerves and epithelial neuroendocrine cells (1). These reductions are associated with fewer asthma exacerbations. However, little is known about the efficacy of this therapy on cough.Objective: To describe a patient with severe, cough-predominant asthma whose cough was alleviated by bronchial thermoplasty.Case Report: A 35-year-old woman presented with a 2.5-year history of chronic cough. The patient was diagnosed with asthma 6 months earlier on the basis of wheezing on auscultation and the ability of inhaled salbutamol ...References1. Pretolani M, Bergqvist A, Thabut G, Dombret MC, Knapp D, Hamidi F, et al. Effectivenestiof bronchial thermoplasty in patients with severe refractory asthma: clinical and histopathologic correlations. J Allergy Clin Immunol. 2017;139:1176-85. [PMID: 27609656] doi:10.1016/j.jaci.2016.08.009 CrossrefMedlineGoogle Scholar2. Kanemitsu Y, Niimi A, Matsumoto H, Iwata T, Ito I, Oguma T, et al. Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma. Allergol Int. 2016;65:320-6. [PMID: 27055910] doi:10.1016/j.alit.2016.02.014 CrossrefMedlineGoogle Scholar3. Matsumoto H, Niimi A, Takemura M, Ueda T, Yamaguchi M, Matsuoka H, et al. Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study. Cough. 2009;5:3. [PMID: 19272144] doi:10.1186/1745-9974-5-3 CrossrefMedlineGoogle Scholar4. Satia I, Badri H, Woodhead M, O'Byrne PM, Fowler SJ, Smith JA. The interaction between bronchoconstriction and cough in asthma [Letter]. Thorax. 2017;72:1144-6. [PMID: 28235887] doi:10.1136/thoraxjnl-2016-209625 CrossrefMedlineGoogle Scholar5. Satia I, Tsamandouras N, Holt K, Badri H, Woodhead M, Ogungbenro K, et al. Capsaicin-evoked cough responses in asthmatic patients: evidence for airway neuronal dysfunction. J Allergy Clin Immunol. 2017;139:771-9. [PMID: 27444176] doi:10.1016/j.jaci.2016.04.045 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Nagoya City University, Nagoya, Japan (Y.K., O.T., K.F., T.A., A.N.)Acknowledgment: The authors thank Drs. Yuki Kitamura, Norihisa Takeda, Yutaka Ito, Keima Ito, Yoshitsugu Inoue, Satoshi Fukuda, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, and Tesuya Oguri (Nagoya City University) for their technical assistance and fruitful discussion.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0748.This article was published at Annals.org on 13 March 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIncreased Capsaicin Sensitivity in Patients with Severe Asthma Is Associated with Worse Clinical OutcomeInterfering with airway nerves in cough associated with asthma 3 July 2018Volume 169, Issue 1Page: 61-62KeywordsAsthmaInhalationNervesNitric oxidePneumoniaPulmonary functionQuality of lifeQuestionnairesSmooth musclesTemperature ePublished: 13 March 2018 Issue Published: 3 July 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...