tbuckley/cabot-search huggingface dataset:
La tendencia internacional de los serotipos de salmonella de 1998 a 2003 – un informe de la Red de vigilancia Enter-net
Authors: I. S.T. Fisher
Journal: Eurosurveillance (2004)

Uno de los objetivos de toda actividad de vigilancia es seguir la evolucion de las infecciones. Desde 1993, la Red Internacional de vigilancia de las infecciones entericas humanas, Enter-net, recoge y publica datos sobre las infecciones humanas por salmonella confirmadas por laboratorio. El numero de casos identificados aumento en la mitad de la decada de los 90, alcanzando el maximo en 1997. Este articulo describe la disminucion posterior de los serotipos de salmonelas notificados entre 1998 y 2003 por los laboratorios nacionales de referencia que participan en esta Red de vigilancia. Durante este periodo, el numero total de casos humanos disminuyo de 220.698 a 142.891. A pesar de este descenso, las salmonelosis siguen siendo una de las principales causas de morbilidad en el hombre.
European Antimicrobial Resistance Surveillance System (EARSS): suscettibilità dei ceppi invasivi di Staphylococcus aureus
Authors: I Veldhuijzen, S L A M Bronzwaer, J Degener, J. L. Kool, Earss participants
Journal: Eurosurveillance (2000)

Oltre 400 laboratori partecipano all’EARSS (European Antimicrobial Resistance Surveillance System) e inviano dati all’Istituto Nazionale di Sanita Pubblica e Ambiente (RIVM) dei Paesi Bassi. Sono attesi ogni anno dati su circa 14 000 isolati di Staphylococcus aureus da sangue e circa 6 000 isolati di infezioni da Streptococcus pneumoniae. I dati pubblicati dopo i 18 mesi dello studio di fattibilita suggeriscono che la resistenza alla meticillina dei ceppi di S. aureus isolati dal sangue e piu comune nei paesi dell’Europa meridionale rispetto a quelli settentrionali.
Guías BICHAT para el manejo clínico de los virus de la fiebre hemorrágica y de los virus de la fiebre hemorrágica relacionados con el bioterrorismo
Authors: P Bossi, A Tegnell, A Baka, F van Loock, J Hendriks, A Werner, H Maidhof, G Gouvras
Journal: Eurosurveillance (2004)

El grupo formado por los virus de la fiebre hemorragica (VFH) produce una enfermedad clinica febril que se caracteriza por las hemorragias. Los VFH potencialmente vinculados a una amenaza biologica son los de Ebola y Marburg (Filoviridae), los arenavirus
TCT-172 Everolimus-Eluting Bioresorbable Vascular Scaffolds for Percutaneous Treatment of Chronic Total Coronary Occlusions: 1 Year Optical Coherence Tomography findings from the GHOST-CTO Registry
Authors: Alessio La Manna, Eligio Miccichè, Guido D'Agosta, Gabriel Tensol Rodrigues Pereira, Guilherme F. Attizzani, Piera Capranzano, Davide Capodanno, Corrado Tamburino
Journal: Journal of the American College of Cardiology (2017)
Assessing the extent of non-aggressive cancer in clinically detected stage I non-small cell lung cancer
Authors: Minal S Kale, Keith Sigel, Grace Mhango, Juan P Wisnivesky
Journal: Thorax (2017)

Overdiagnosis among clinically detected lung cancers likely consists of cases that are non-aggressive and slowly progressive and will never disseminate, cause symptoms or be a threat to a subject's survival, even if untreated. In this study, we estimate the prevalence of non-aggressive lung cancers from a large, population-based cancer registry.We identified individuals ≥65 years with histologically confirmed, untreated stage I non-small cell lung cancers (NSCLCs) from the Surveillance, Epidemiology, and End Results-Medicare registry. We estimated the rate of non-aggressive lung cancers by determining the point at which the cumulative lung cancer-specific survival curve no longer changed (ie, the slope approaches zero). At this point, there are no additional deaths due to progressive lung cancer observed among untreated patients after adjusting for deaths from competing risks (these long-term survivors can be considered 'non-aggressive cases).The overall rate of non-aggressive cancers among 2197 clinically detected cases of untreated stage I NSCLC was 2.4%, 95% CI: 1.0% to 3.8%. The rate of non-aggressive cancer was 1.9% (95% CI: 0.0% to 4.9%) for women and 2.4% (95% CI: 0.7% to 4.1%) for men (p=0.84). When stratifying by tumour size, non-aggressive cancer rates were 10.2% (95% CI: 0.0% to 29.3%), 2.1% (95% CI: 0.0% to 9.2%), 4.9% (95% CI: 0.0% to 10.3%), 1.8% (95% CI: 0.0% to 5.2%) and 0.0% (95% CI: 0.0% to 1.0%) for tumour sizes <15 mm, 15-24 mm, 25-34 mm, 35-44 mm and ≥45 mm, respectively. In comparison with the smallest tumour sizes (<15 mm), the rates of non-aggressive cancers were not statistically significantly different for tumour sizes 15-24 mm (p=0.36), 25-34 mm (p=0.57), 35-44 mm (p=0.38) and tumour sizes >45 mm (p=0.30).We found relatively low rates of non-aggressive cancers among clinically detected, stage I NSCLC regardless of sex or size. Our findings suggest that most clinically diagnosed early stage cancers should be treated with curative intent.
Abstract 17227: A New Noninvasive iPhone Application to Monitor Left Ventricle Ejection Fraction in Heart Failure Patients
Authors: Niema M Pahlevan, Derek Rinderknecht, Peyman Tavallali, Marianne Razavi, Thao T Tran, Michael Fong, Robert A Kloner, Marie Csete, Morteza Gharib
Journal: Circulation (2016)

Introduction: Health care systems have expended major effort on monitoring heart failure (HF) status in outpatients, with a focus on reducing re-admission for decompensated heart failure and adjust...
pH-Sensitive Nano-Complexes Overcome Drug Resistance and Inhibit Metastasis of Breast Cancer by Silencing Akt Expression
Authors: Jieying Yin, Tianqun Lang, Dongmei Cun, Zhong Zheng, Yan Huang, Qi Yin, Haijun Yu, Yaping Li
Journal: Theranostics (2017)

The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX and a siRNA, siAkt, directed at silencing the Akt expression. Methods: The pH-sensitive amphiphilic polymer, poly [(1,4-butanediol)-diacrylate-β-N, N-diisopropylethylenediamine]-polyethyleneimine (BDP) was synthesized. The PTX-loaded BDP micelle/siAkt nano-complex (PMA) was prepared and characterized. The cellular uptake, cytotoxicity, RNA interference efficiency, biodistribution, pharmacokinetics, pharmacodynamics, and biocompatibility of PMA in the murine metastatic breast cancer 4T1 cells and the 4T1 tumor-bearing mice were evaluated. Results: PMA was stable at the neutral as well as tumor extracellular pH and released the drugs in the intra-endo/lysosome acidic environment. In 4T1 cells, the RNA interference against the Akt gene down-regulated the expression of Akt and P-glycoprotein and up-regulated the expression of Caspase-3. The down-regulated P-gp inhibits the efflux of PTX thereby increasing its intracellular concentration, improving the cytotoxicity, and inhibiting the migration and invasion of 4T1 cells. In the 4T1 tumor-bearing mice, co-delivery of PTX and siAkt by PMA achieved a tumor inhibiting rate of 94.1% and suppressed 96.8% lung metastases. PMA did not cause pathological lesions in normal organs. Conclusion: PMA, by virtue of overcoming drug resistance and simultaneously restraining lung metastasis, might be an efficient drug delivery system for the therapy of breast cancer.
Prognostic factor of patients with advanced non-small cell lung cancer receiving best supportive care
Authors: Takayuki Kishikawa, Shingo Masuda, Shinya Oda, Keisuke Yamaguchi, Yuichiro Furusato, Ayaka Furusato, Shota Yamaguchi, Shigehiro Inoue, Takahiro Yasaka
Journal: Annals of Oncology (2017)
Détection des menaces dues aux maladies infectieuses aux Pays-Bas : le comité d’alerte rapide
Authors: J C Rahamat-Langendoen, J A van Vliet, A Wm Suijkerbuijk
Journal: Eurosurveillance (2006)

Aux Pays-Bas, le comite d’alerte rapide a ete mis en place pour detecter a temps et de maniere exhaustive les menaces pour la sante publique dues aux maladies infectieuses. L’article decrit les resultats d’une evaluation retrospective et descriptive de l’exhaustivite des evenements detectes par le comite d’alerte rapide.
Les informations sur les epidemies de maladies infectieuses aux Pays-Bas en 2002 et 2003 rapportees dans le Journal neerlandais de medecine (Nederlands Tijdschrift voor Geneeskunde), sur les evenements lies aux maladies infectieuses dans d’autres pays ont ete comparees aux rapports des reunions hebdomadaires du comite d’alerte rapide neerlandais. Pour toute epidemie ou evenement survenu a l’etranger mais non mentionne dans les reunions du comite d’alerte, il s’agissait alors de trouver les raisons de cette omission. Pour les evenements touchant d’autres pays, la raison pour en tenir compte ou non dans les reunions du comite etait lie au fait qu’ils constituaient, ou non, une menace pour la sante publique aux Pays-Bas. 
Toutes les epidemies de maladies infectieuses aux Pays-Bas, publiees ou mentionnees dans le Journal neerlandais de medecine ont fait l’objet de discussions au sein du comite d’alerte. Cependant, trois evenements survenus dans d’autres pays en 2002 n’avaient pas ete discutes par le comite, alors qu’ils auraient du l’etre, selon le critere decrit precedemment. Il s’agit de l’epidemie de grippe aviaire A/H5N1 chez des coqs domestiques a Hong Kong, de l’augmentation de porteurs de microorganismes producteurs de beta-lactamases a spectre elargi chez des patients hospitalises en Ecosse, ainsi que les epidemies de rougeole dans plusieurs pays. En 2003, le comite a traite de tous les evenements survenus dans d’autres pays representant une menace potentielle pour les Pays-Bas. 
En 2002 et 2003, le comite d’alerte rapide a detecte pratiquement toutes les menaces dues aux maladies infectieuses et les epidemies de maladies infectieuses ayant un impact national et publiees dans diverses sources de la litterature.
Measles outbreak linked to European B3 outbreaks, Wales, United Kingdom, 2017
Authors: Jonny Currie, Llion Davies, Joanne McCarthy, Malorie Perry, Catherine Moore, Simon Cottrell, Mererid Bowley, Chris Williams, Ananda Giri Shankar, Rhianwen Stiff
Journal: Eurosurveillance (2017)

The United Kingdom achieved interrupted endemic measles transmission for 36 months in 2016. Despite this, ongoing challenges from sporadic measles cases typically imported from abroad remain. We summarise a B3 measles genotype outbreak in south-east Wales occurring between May and September 2017, linked with other European outbreaks, and lessons learnt. Seventeen confirmed cases and one probable case occurred principally in education and healthcare-settings. Six confirmed cases attended healthcare settings when infectious, without being isolated.
Response to Comment on Ely et al. A National Effort to Prevent Type 2 Diabetes: Participant-Level Evaluation of CDC’s National Diabetes Prevention Program. Diabetes Care 2017;40:1331–1341
Authors: Elizabeth K. Ely, Stephanie M. Gruss, Elizabeth T. Luman, Ann L. Albright
Journal: Diabetes Care (2017)

In response to Ritchie et al. (1) regarding the first report from the Centers for Disease Control and Prevention (CDC) of findings from the National Diabetes Prevention Program (National DPP) (2), we respectfully submit the following.

Our article (2) is an initial, preliminary report of data from the first few years of program implementation and data collection only. It describes the experience of 14,747 adults enrolled in year-long type 2 diabetes prevention programs from February 2012 through January 2016. As of July 2017, the National DPP had …
Mapping the pharmaceutical design space by amorphous ionic liquid strategies
Authors: Johannes Wiest, Marco Saedtler, Anja Balk, Benjamin Merget, Toni Widmer, Heike Bruhn, Marc Raccuglia, Elbast Walid, Franck Picard, Helga Stopper, Wolfgang Dekant, Tessa Lühmann, Christoph Sotriffer, Bruno Galli, Ulrike Holzgrabe, Lorenz Meinel
Journal: Journal of Controlled Release (2017)
Radiation-Induced DNA Damage in Operators Performing Endovascular Aortic Repair
Authors: Tamer El-Sayed, Ashish S. Patel, Jun S. Cho, James A. Kelly, Francesca E. Ludwinski, Prakash Saha, Oliver T. Lyons, Alberto Smith, Bijan Modarai, M Tyrrell, P Gkoutzios, S Abisi, S Black, H Zayed, RE Bell, M Sallam, L Biasi, SD Patel, T Donati, M Dialynas, B Sandford, S Redwood, S Perera, A Pavlidis, B Prendergast, J Gill
Journal: Circulation (2017)

Radiation exposure during fluoroscopically guided interventions such as endovascular aortic repair (EVAR) is a growing concern for operators. This study aimed to measure DNA damage/repair markers in operators perfoming EVAR.Expression of the DNA damage/repair marker, γ-H2AX and DNA damage response marker, phosphorylated ataxia telangiectasia mutated (pATM), were quantified in circulating lymphocytes in operators during the peri-operative period of endovascular (infrarenal, branched, and fenestrated) and open aortic repair using flow cytometry. These markers were separately measured in the same operators but this time wearing leg lead shielding in addition to upper body protection and compared with those operating with unprotected legs. Susceptibility to radiation damage was determined by irradiating operators' blood in vitro.γ-H2AX and pATM levels increased significantly in operators immediately after branched endovascular aortic repair/fenestrated endovascular aortic repair (P<0.0003 for both). Only pATM levels increased after infrarenal endovascular aortic repair (P<0.04). Expression of both markers fell to baseline in operators after 24 hours (P<0.003 for both). There was no change in γ-H2AX or pATM expression after open repair. Leg protection abrogated γ-H2AX and pATM response after branched endovascular aortic repair/fenestrated endovascular aortic repair. The expression of γ-H2AX varied significantly when operators' blood was exposed to the same radiation dose in vitro (P<0.0001).This is the first study to detect an acute DNA damage response in operators performing fluoroscopically guided aortic procedures and highlights the protective effect of leg shielding. Defining the relationship between this response and cancer risk may better inform safe levels of chronic low-dose radiation exposure.
Risk factors of CINV induced by CDDP in antiemetic triplet regimen including palonosetron or granisetron: TRIPLE study
Authors: Masahiko Nakao, Koji Takeda, Kenichi Suzuki, Daiki Tsuji, Yohei Kawasaki, Kunihiko Itoh, Takeharu Yamanaka, Nobuyuki Yamamoto
Journal: Annals of Oncology (2017)
Hyper‐CVAD plus nelarabine in newly diagnosed adult T‐cell acute lymphoblastic leukemia and T‐lymphoblastic lymphoma
Authors: Yasmin Abaza, Hagop M. Kantarjian, Stefan Faderl, Elias Jabbour, Nitin Jain, Deborah Thomas, Tapan Kadia, Gautam Borthakur, Joseph D. Khoury, Jan Burger, William Wierda, Susan O'Brien, Marina Konopleva, Alessandra Ferrajoli, Partow Kebriaei, Bouthaina Dabaja, Steven Kornblau, Yesid Alvarado, Naval Daver, Naveen Pemmaraju, Prithviraj Bose, Philip Thompson, Hind Al Azzawi, Mary Kelly, Rebecca Garris, Preetesh Jain, Guillermo Garcia‐Manero, Jorge Cortes, Farhad Ravandi
Journal: American Journal of Hematology (2017)

Nelarabine, a water soluble prodrug of 9-β-D-arabinofuranosylguanine (ara-G), is a T-cell specific purine nucleoside analogue. Given its activity in relapsed and refractory T acute lymphoblastic leukemia (T-ALL) and T lymphoblastic lymphoma (T-LBL), we sought to define its role in the frontline treatment of adult patients. Therefore, we conducted a single arm phase 2 study to determine the safety and efficacy of nelarabine in combination with hyper-CVAD in newly diagnosed patients. For induction/consolidation, patients received eight cycles of hyper-CVAD alternating with high-dose methotrexate and cytarabine plus two cycles of nelarabine given at a dose of 650 mg/m
COPD: algorithms and clinical management
Authors: Rosa Faner, Alvar Agustí
Journal: European Respiratory Journal (2017)

When you are invited to write an Editorial on a given paper, you are expected to provide a strong personal opinion that will both attract the readers' interest whilst giving food for thought. Here, we have been asked to try to achieve both goals with respect to the paper by Burgel et al. [1] on the use of a simple algorithm for the identification of clinical chronic obstructive pulmonary disease (COPD) phenotypes published in this same issue of the European Respiratory Journal ( ERJ ). Can algorithms help the practicing clinician to prescribe the best treatment? <http://ow.ly/44yF30fwCc9>
Predictors of clinical outcomes in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone acetate or placebo: An exploratory post-hoc analysis of COU-AA-302 trial data.
Authors: Dominic Pilon, Ajay S. Behl, Rhiannon Kamstra,, Yongling Xiao, Marie-Helene Lafeuille, Patrick Lefebvre, Stephen J. Freedland
Journal: Journal of Clinical Oncology (2017)

e16529 Background: A post-hoc analysis of COU-AA-302 trial data showed that brief pain inventory (BPI), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and bone metastases were predictors for overall survival in men with mCRPC treated with AA+P. This study aimed to identify baseline predictors of other clinical outcomes. Methods: COU-AA-302 trial data were used to develop predictive models for prostate-specific antigen (PSA) progression, Eastern Cooperative Oncology Group performance status (ECOG PS) deterioration, and opiate use. Associations between baseline factors and outcomes were first assessed using multivariable Cox models among AA+P patients (Step 1). In Step 2, interaction testing was conducted between treatment (AA+P vs. placebo) and each potential predictor (P &lt; 0.2) identified in Step 1. Final Cox models included predictors and any significant interactions (p &lt; 0.05). Results: A total of 1,034 men (525 AA+P; 509 placebo) were included in the analysis. Baseline BPI, PSA, LDH, and ALP were predictors of PSA progression and opiate use regardless of AA+P or placebo with higher values indicating higher risks (all P &lt; 0.05). Younger age, shorter time from luteinizing hormone-releasing hormone to randomization, higher Gleason score, and lower PSA at diagnosis were also associated with higher risks of opiate use: (all P &lt; 0.05). For ECOG PS deterioration, higher baseline BPI, PSA, LDH, and Gleason score, older age, and lower baseline ECOG were associated with higher risks regardless of AA+P or placebo (all P &lt; 0.05). Baseline ALP and site of metastasis also predicted ECOG PS deterioration but the effect varied by treatment (lower risk in AA+P versus placebo; both interactions’ P &lt; 0.05). Conclusions: Predictors of PSA progression, ECOG PS deterioration, and opiate use were identified in AA+P and placebo-treated men with mCRPC. No predictors were associated with worse outcomes for AA+P versus placebo, while the negative impact of certain predictors on ECOG PS was favorably modified by AA+P. Further study is needed on the relationship between AA+P and prognostic factors.
Demystifying Neurosarcoidosis and Informing Prognosis
Authors: Jeffrey M. Gelfand
Journal: JAMA Neurology (2017)

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TCT-828 Long-Term Outcomes of Final Kissing Balloon Technique After Crossover Stenting for Left Main Coronary Artery: From the AOI-LMCA registry
Authors: Koji Nishida, Mamoru Toyofuku, Daisuke Furukawa, Hirooki Higami, Masanobu Ohya, Yasushi Fuku, Kyohei Yamaji, Hiromi Muranishi, Yuhei Yamaji, Tomohisa Tada, Euihong Ko, Kenji Ando, Kazushige Kadota, Hiroki Sakamoto, Takashi Tamura, Kazuya Kawai, Takeshi Morimoto, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2017)
The 10 years achievement of the ambulatory chemotherapy center in Anjo Kosei hospital
Authors: Yuichiro Inagaki, Yuki Takeuchi, Hitomi Ohashi, Kanae Imai, Tomonori Kato, Takashi Seki, Kiyoshi Hiramatsu, Junko Arima, Eiji Yoneyama, Masashi Sawa
Journal: Annals of Oncology (2017)
TCT-793 Discrepancy Between GOLD criteria and STS Risk Assessment Score of COPD for Perioperative Evaluation of Transcatheter Aortic Valve Replacement
Authors: Mohamad Kabach, Jesus Pino Moreno, Abdulah Alrifai, Elie Donath, Varun Shah, Pradeep Dayanand, Edwin Grajeda, Lawrence Lovitz, Mark Rothenberg, Roberto J. Cubeddu, Cristiano Faber, Marcos Nores
Journal: Journal of the American College of Cardiology (2017)
Erratum: Corrigendum: Germline hypomorphic CARD11 mutations in severe atopic disease
Authors: Chi A Ma, Jeffrey R Stinson, Yuan Zhang, Jordan K Abbott, Michael A Weinreich, Pia J Hauk, Paul R Reynolds, Jonathan J Lyons, Celeste G Nelson, Elisa Ruffo, Batsukh Dorjbal, Salomé Glauzy, Natsuko Yamakawa, Swadhinya Arjunaraja, Kelsey Voss, Jennifer Stoddard, Julie Niemela, Yu Zhang, Sergio D Rosenzweig, Joshua J McElwee, Thomas DiMaggio, Helen F Matthews, Nina Jones, Kelly D Stone, Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti, Brian Kim, Megan A Cooper, Neil D Romberg, Eric Meffre, Erwin W Gelfand, Andrew L Snow, Joshua D Milner
Journal: Nature Genetics (2017)
Computational Radiomics System to Decode the Radiographic Phenotype
Authors: Joost J.M. van Griethuysen, Andriy Fedorov, Chintan Parmar, Ahmed Hosny, Nicole Aucoin, Vivek Narayan, Regina G.H. Beets-Tan, Jean-Christophe Fillion-Robin, Steve Pieper, Hugo J.W.L. Aerts
Journal: Cancer Research (2017)

Radiomics aims to quantify phenotypic characteristics on medical imaging through the use of automated algorithms. Radiomic artificial intelligence (AI) technology, either based on engineered hard-coded algorithms or deep learning methods, can be used to develop noninvasive imaging-based biomarkers. However, lack of standardized algorithm definitions and image processing severely hampers reproducibility and comparability of results. To address this issue, we developed PyRadiomics, a flexible open-source platform capable of extracting a large panel of engineered features from medical images. PyRadiomics is implemented in Python and can be used standalone or using 3D Slicer. Here, we discuss the workflow and architecture of PyRadiomics and demonstrate its application in characterizing lung lesions. Source code, documentation, and examples are publicly available at www.radiomics.io With this platform, we aim to establish a reference standard for radiomic analyses, provide a tested and maintained resource, and to grow the community of radiomic developers addressing critical needs in cancer research. Cancer Res; 77(21); e104-7. ©2017 AACR.
TCT-139 Primary Left Ventricular Unloading with a Trans-valvular Axial Flow Pump Limits Ischemic Heart Failure After Acute Myocardial Infarction
Authors: Lara Reyelt, Michele Esposito, Kevin Morine, Shiva Annamalai, Courtney Bogins, Peter Natov, Hyunji Koo, Richard Karas, Navin Kapur
Journal: Journal of the American College of Cardiology (2017)