tbuckley/cabot-search huggingface dataset:
Type 3c diabetes associated with pancreatic disease is often misdiagnosed, finds study
Authors: Susan Mayor
Journal: BMJ (2017)

Type 3c diabetes, or diabetes of the exocrine pancreas, is currently misdiagnosed as type 2 diabetes in most patients, a large UK primary care study has reported.1

“Our research shows that the majority of people with type 3c diabetes are being misdiagnosed, putting both their short and long term health at risk,” said lead author Simon de Lusignan, from the University of Surrey, UK.

Type 3c diabetes occurs when the structure and function of the pancreas are disrupted by disease. In contrast, type 2 diabetes generally results from metabolic changes that affect how …
TCT-181 Outcomes of Left Main PCI vs CABG According the Number of Diseased Coronary Arteries: The EXCEL trial
Authors: Erick Schampaert, Patrick Serruys, A. Pieter Kappetein, Nicholas Lembo, William Brown, Adrian Banning, Ovidiu Dressler, Serge Doucet, Uday Trivedi, David Hildick-Smith, Joseph Sabik, Gregg Stone
Journal: Journal of the American College of Cardiology (2017)
TCT-813 Clinical results at a very long-term follow-up of percutaneous coronary intervention in bifurcated left main coronary artery
Authors: Ignacio Sanchez-Perez, Jesus Piqueras-Flores, Alfonso Jurado-Román, María Thiscal López Lluva, Natalia Pinilla-Echeverri, Ramón Maseda Uriza, Fernando Lozano
Journal: Journal of the American College of Cardiology (2017)
4A.03 Predictive Utility of c-reactive Protein (CRP) in Advanced Stage Lung Cancer Treated with Anti-Programmed Cell Death-1 (PD-1) Therapy
Authors: A.R. Naqash, C.R.G. Stroud, C. Cherry, M. Muzaffar, M. Bowling, P.R. Walker
Journal: Journal of Thoracic Oncology (2017)
Rapporto riassuntivo da Amsterdam: aumento delle malattie sessualmente trasmesse e dei comportamenti sessuali a rischio tra omosessuali maschi, legati all'introduzione di nuovi farmaci anti-HIV
Authors: G Stolte, N H T M Dukers, J B F de Wit, H Fennema, R A Coutinho
Journal: Eurosurveillance (2002)

L'inquietudine provocata dall'aumento delle malattie sessualmente trasmesse (MST) ad Amsterdam e alla base di due studi condotti dal dipartimento della ricerca sull'AIDS dei servizi sanitari municipali. I risultati indicano che l'introduzione di trattamenti antiretrovirali fortemente attivi (Highly Active Antiretroviral Therapies, HAART) puo avere avuto un'influenza sull'aumento delle MST e sui comportamenti sessuali a rischio ad Amsterdam.
A mortalidade na Espanha durante a onda de calor do verão de 2003
Authors: F Simon, G Lopez-Abente, E Ballester, F Martinez
Journal: Eurosurveillance (2005)

As altas temperaturas experimentadas na Europa no verao de 2003 tiveram um efeito na mortalidade em varios paises incluindo a Espanha. Este capitulo descreve a mortalidade do 1° de Junho ao 31 de Agosto, e avalia o impacto das ondas de calor sobre ela na Espanha. 
O numero de obitos foi fornecido pelos Registros Civis das 50 capitais de provincia. A mortalidade observada foi comparada com a mortalidade esperada, estimada usando um modelo de regressao de Poisson sobre series historicas de obitos, corrigido pela tendencia ascendente e a estacao. As informacoes meteorologicas foram fornecidas pelo Instituto Nacional de Meteorologia.
Espanha experimentou tres periodos de altas temperaturas. O excesso de obitos associado foi de 8% (43 212 observados por 40 046 esperados). O excesso de mortalidade afetou exclusivamente pessoas de mais de 75 anos (15% mais obitos que esperados para o grupo de idade 75 a 84 e 29% para os mais de 84 anos). 
Este fenomeno (excesso de mortalidade associado a altas temperaturas ambientais) e um problema de saude publica emergente por seu risco crescente ligado ao velhecimento da populacao espanhola e a maior frequencia prevista de ondas de calor devido ao aquecimento global. Sistemas de alerta e resposta deveriam ser criados, baseados na monitorizacao dos riscos naturais, dos servicios de emergencia e dos obitos e no reforco da capacidade de resposta dos servicos sanitarios e sociais.
Despistaje de marcadores de infecciones por VIH, VHB y VHC en donantes de sangre de Francia y riesgo residual de transmisión de estos virus por transfusión de sangre
Authors: J Pillonel, C Saura, A M Couroucé
Journal: Eurosurveillance (1998)

La prevencion de la transmision de infecciones viricas a traves de hemocomponentes se consigue de dos maneras: la seleccion de donantes de sangre que tiene por objetivo impedir que las personas con factores de riesgo de enfermedades contagiosas transmitidas por transfusion lleguen a realizar donaciones, y la serie de despistajes sistematicos de las donaciones que permiten eliminar las infectadas y excluir a los donantes infectados.
A doença do legionário na Europa em 2003-2004
Authors: K D Ricketts, C Joseph
Journal: Eurosurveillance (2005)

Uma vez por ano, os paises colaboradores do Grupo de trabalho europeu para a vigilância da doenca do legionario associada a viajens (EWGLINET) tem que fornecer uma serie de dados com informacao epidemiologica e microbiologica dos casos de doenca do legionario (infeccoes nosocomiais, comunitarias ou associadas com viajens) detectados no seu pais durante o mesmo ano. O artigo seguinte presenta os dados correspondentes a 2003 e 2004. Durante este periodo, 9166 casos foram declarados por 35 paises, dos quais 941 casos estavam associados a surtos. Quatorze paises declararam um total de 218 casos. A taxa de infeccao variava de um pais a outro, de 28,7% a menos de um caso por milhao de habitantes. Esta informacao e importante, pois permite que os paises avaliem a efficacia dos seus programas de vigilância para a deteccao de casos.
TCT-510 Early Unloading With Impella CP® Heart Pump In Cardiogenic Shock Complicating An Acute Myocardial Infarction Improves Outcomes: Results from the Dresden Impella Registry
Authors: Tobias Löhn, Carl Kuehns, Georg Ende, Christian Pfluecke, Uwe Speiser, None Karim Ibrahim
Journal: Journal of the American College of Cardiology (2017)
TCT-250 3-year Clinical Outcomes of Durable-Polymer Zotarolimus-Eluting and Biodegradable-Polymer Biolimus-Eluting Coronary Stents in Patients with Diabetes Mellitus (a SORT OUT VI Substudy)
Authors: Bent Raungaard, Evald Christiansen, Svend Eggert Jensen, Henrik Hansen, Leif Thuesen, Jens Aaroe, Anton Villadsen, Michael Maeng, Steen Dalby Kristensen, Morten Madsen, Karsten Veien, Anders Junker, Lisette Okkels Jensen
Journal: Journal of the American College of Cardiology (2017)
SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance
Authors: Arturo Orlacchio, Michela Ranieri, Martina Brave, Valeria Antico Arciuch, Toni Forde, Daniela De Martino, Karen E. Anderson, Phillip Hawkins, Antonio Di Cristofano
Journal: Cancer Research (2017)

Activation of the PI3K-AKT signaling cascade is a common critical event during malignant transformation. In this study, we used thyroid gland epithelial cells and a series of genetically engineered mouse strains as model systems to demonstrate that, although necessary, AKT activation is not sufficient for PI3K-driven transformation. Instead, transformation requires the activity of the PDK1-regulated AGC family of protein kinases. In particular, SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations. Notably, cotargeting SGK1 and AKT resulted in significantly higher growth suppression than inhibiting either PI3K or AKT alone. Overall, these findings underscore the clinical relevance of AKT-independent pathways in tumors driven by genetic lesions targeting the PI3K cascade. Cancer Res; 77(24); 6914-26. ©2017 AACR.
Abstract 42: Simultaneous development of Kawasaki Disease associated with adenovirus infection in identical twins
Authors: Sayaka Fukuda, Maya Fujiwara, Shuichi Ito, Jun Abe, Nozumu Hanaoka, Tsuguto Fujimoto, Hiroshi Katsumori
Journal: Circulation (2015)

Background: The cause of Kawasaki disease (KD) remains unknown. However, many studies have suggested that specific genetic factors and some infectious agents could be associated with the onset of KD. Human adenovirus (AdV) infection is one of the triggering events in KD. We experienced identical twins who sequentially developed KD in conjunction with AdV infection. Patients: The patients were 4-year-old identical twin boys. The elder brother developed a high fever and was diagnosed with AdV infection by an immunochromatographic kit for AdV (IC-kit). He was transferred to our institute after persistence of fever for 7 days. On admission, he already fulfilled all of the diagnostic criteria of KD. The laboratory data were as follows: WBC, 9700/μl; CRP, 2.42 mg/dl; IFN-γ, 99.8 pg/ml; and TNF-α, 10.9 pg/ml. He received intravenous immunoglobulin (IVIG) and aspirin, and responded well without coronary artery abnormalities. The younger brother, who was also IC-kit-positive, was hospitalized on the same day as his elder brother after persistence of fever for 3 days. The data on admission were as follows: WBC, 12,600/μl; CRP, 5.54 mg/dl; IFN-γ, 105.0 pg/ml; and TNF-α, 33.6 pg/ml. Although he developed all of the KD symptoms by the 4th day, his fever spontaneously subsided on the 6th day without IVIG or aspirin. He developed dilation of the coronary artery on the 10th day at the left circumflex artery bifurcation area. This disappeared after 3 months with antiplatelet therapy. AdV type 3 (AdV3) DNA was detected in both of the patients’ stool samples by PCR, and AdV3 was isolated from the younger brother’s stool sample. Moreover, serum neutralizing antibody to AdV3 was greatly elevated in both of the patients. Discussion: Identical twins who simultaneously develop KD are rare. Both of the twin brothers were infected with AdV3 immediately before they developed symptoms of KD. The combined condition of genetic susceptibility and an infection could be an essential trigger in development of KD.
TGFβ Promotes Genomic Instability after Loss of RUNX3
Authors: Vaidehi Krishnan, Yu Lin Chong, Tuan Zea Tan, Madhura Kulkarni, Muhammad Bakhait Bin Rahmat, Lavina Sierra Tay, Haresh Sankar, Doorgesh S. Jokhun, Amudha Ganesan, Linda Shyue Huey Chuang, Dominic C. Voon, GV Shivashankar, Jean-Paul Thiery, Yoshiaki Ito
Journal: Cancer Research (2017)

Studies of genomic instability have historically focused on intrinsic mechanisms rather than extrinsic mechanisms based in the tumor microenvironment (TME). TGFβ is the most abundantly secreted cytokine in the TME, where it imparts various aggressive characteristics including invasive migration, drug resistance, and epithelial-to-mesenchymal transition (EMT). Here we show that TGFβ also promotes genomic instability in the form of DNA double strand breaks (DSB) in cancer cells that lack the tumor suppressor gene RUNX3 Loss of RUNX3 resulted in transcriptional downregulation of the redox regulator heme oxygenase-1 (HO-1 or HMOX1). Consequently, elevated oxidative DNA damage disrupted genomic integrity and triggered cellular senescence, which was accompanied by tumor-promoting inflammatory cytokine expression and acquisition of the senescence-associated secretory phenotype (SASP). Recapitulating the above findings, tumors harboring a TGFβ gene expression signature and RUNX3 loss exhibited higher levels of genomic instability. In summary, RUNX3 creates an effective barrier against further TGFβ-dependent tumor progression by preventing genomic instability. These data suggest a novel cooperation between cancer cell-extrinsic TGFβ signaling and cancer cell-intrinsic RUNX3 inactivation as aggravating factors for genomic instability.Significance: RUNX3 inactivation in cancer removes an antioxidant barrier against DNA double strand breaks induced by TGFβ expressed in the tumor microenvironment. Cancer Res; 78(1); 88-102. ©2017 AACR.
Updated Cost-effectiveness Assessments of PCSK9 Inhibitors From the Perspectives of the Health System and Private Payers
Authors: Alejandro Arrieta, Jonathan C. Hong, Rohan Khera, Salim S. Virani, Harlan M. Krumholz, Khurram Nasir
Journal: JAMA Cardiology (2017)

Preliminary cost-effectiveness analyses of proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) were based on benefits estimated from reductions in low-density lipoprotein cholesterol that occurred in PCSK9i trials with variable results. The recent Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) trial provides better information about the effectiveness of the drug.To use the trial results to determine the cost-effectiveness of a PCSK9i and statin treatment strategy compared with a statin alone strategy.We derived observed rates of events, outcomes, cost of care, and health insurance from existing literature for a theoretical cohort of patients designed to resemble the FOURIER PCSK9i trial population and created a Markov model during the time horizon of a full lifetime.We evaluated the incremental cost-effectiveness ratio from a health system perspective, and the return on investment from a private payer perspective. For both measures, we assumed an annual PCSK9i drug price of $14 300, with a lapse in US patent protection that would reduce the price by 43% in year 12. Costs were reported in 2016 US dollars.This study modeled 1000 hypothetical patients with attributes similar to those of the FOURIER trial cohort. At the current price, the incremental cost-effectiveness ratio of statin plus PCSK9i therapy was $337 729 per quality-adjusted life-year. Our probabilistic sensitivity analysis found that a statin plus PCSK9i strategy had a low probability (<1%) of being cost effective at the commonly accepted societal threshold of $100 000 per quality-adjusted life-year. Furthermore, PCSK9i produced a negative return on investment of 86% for private payers. In our threshold analysis, the price of PCSK9i would need to drop 62%, to $5459 per year, to reach $100 000 per quality-adjusted life year.At current prices, the addition of PCSK9i to statin therapy is estimated to provide an additional quality-adjusted life year for $337 729 . Significant discounts are necessary to meet conventional cost-effectiveness standards.
Should we scrap the target of a maximum four hour wait in emergency departments?
Authors: Peter Campbell, Adrian Boyle, Ian Higginson
Journal: BMJ (2017)

Pressure to achieve arbitrary targets is not a valid improvement strategy and leads to perverse incentives and use of resources, claims <b>Peter Campbell</b>, but <b>Adrian Boyle</b> and <b>Ian Higginson</b> say no alternative exists to keep emergency departments working
Novel Blood-based Transcriptional Biomarker Panels Predict the Late-Phase Asthmatic Response
Authors: Amrit Singh, Casey P. Shannon, Young Woong Kim, Chen Xi Yang, Robert Balshaw, Gabriela V. Cohen Freue, Gail M. Gauvreau, J. Mark FitzGerald, Louis-Philippe Boulet, Paul M. O’Byrne, Scott J. Tebbutt
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

The allergen inhalation challenge is used in clinical trials to test the efficacy of new treatments in attenuating the late-phase asthmatic response (LAR) and associated airway inflammation in subjects with allergic asthma. However, not all subjects with allergic asthma develop the LAR after allergen inhalation. Blood-based transcriptional biomarkers that can identify such individuals may help in subject recruitment for clinical trials as well as provide novel molecular insights.To identify blood-based transcriptional biomarker panels that can predict an individual's response to allergen inhalation challenge.We applied RNA sequencing to total RNA from whole blood (n = 36) collected before and after allergen challenge and generated both genome-guided and de novo datasets: genes, gene-isoforms (University of California, Santa Cruz, UCSC Genome Browser), Ensembl, and Trinity. Candidate biomarker panels were validated using the NanoString platform in an independent cohort of 33 subjects.The Trinity biomarker panel consisting of known and novel biomarker transcripts had an area under the receiver operating characteristic curve of greater than 0.70 in both the discovery and validation cohorts. The Trinity biomarker panel was useful in predicting the response of subjects that elicited different responses (accuracy between 0.65 and 0.71) and subjects that elicit a dual response (accuracy between 0.70 and 0.75) upon repeated allergen inhalation challenges.Interestingly, the biomarker panel containing novel transcripts successfully validated compared with panels with known, well-characterized genes. These biomarker-blood tests may be used to identify subjects with asthma who develop the LAR, and may also represent members of novel molecular mechanisms that can be targeted for therapy.
Incidence of Neurological Complications Secondary to Intrathecal Chemotherapy Used As Either Prophylaxis or Treatment of Leptomeningeal Carcinomatosis
Authors: Diana M Byrnes, Christopher R Dermarkarian, Ryan Kahn, Deukwoo Kwon, Fernando Vargas, Judith Hurley, Justin M. Watts, Jonathan H. Schatz, Ronan T Swords
Journal: Blood (2016)
Abstract 17765: Hemodynamic Assessment of Macro- and Micro-Perfusion and Clinical Outcomes Following Endovascular Therapy for Critical Limb Ischemia
Authors: Laura Young, Grant W Reed, Imad Bagh, Mehdi Shishehbor
Journal: Circulation (2016)

Background: Ankle-brachial index (ABI) assesses lower extremity macro-perfusion, while toe-brachial index (TBI) assesses micro-perfusion. Whether post-procedure or change in ABI or TBI are associat...
TCT-815 The clinical impact of daily glucose fluctuation on cardiovascular events in patients with stable angina pectoris pretreated with lipid-lowering therapy
Authors: Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Yuto Shinkura, Koji Kuroda, Yuichiro Nagano, Takayoshi Toba, Youichirou Sugizaki, Hiroyuki Onishi, Ken-ichi Hirata
Journal: Journal of the American College of Cardiology (2017)
Triquinose humana por Trichinella britovi no sul da França em relação com o consumo de carne de javali congelada
Authors: M Gari-Toussaint, N Tieulié, J L Baldin, J Dupouy-Camet, P Delaunay, J G Fuzibet, Y Le Fichoux, E Pozio, P Marty
Journal: Eurosurveillance (2005)

Seis pacientes foram infectados por Trichinella britovi no sul da Franca depois de ter comido carne de javali que tinha estado congelada a -35°C durante somente sete dias. O exame microscopico de uma amostra de musculo congelado revelou a presenca de larvas encapsuladas de Trichinella, identificadas como T. britovi. Os consumidores de carne de javali devem seguir normas profilacticas individuais, como a cozedura eficaz da carne (ao menos, 65°C no centro do pedaco de carne, durante um minuto como minimo) seguindo as recomendacoes da Comissao Internacional da Triquinose, ou pelo menos quatro semanas de congelacao.
Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression
Authors: Maria Rusan, Kapsok Li, Yvonne Li, Camilla L. Christensen, Brian J. Abraham, Nicholas Kwiatkowski, Kevin A. Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li, Kevin Rhee, Haikuo Zhang, Wankun Chen, Hideki Terai, Tiffany Tavares, Alan L. Leggett, Tianxia Li, Yichen Wang, Tinghu Zhang, Tae-Jung Kim, Sook-Hee Hong, Neermala Poudel-Neupane, Michael Silkes, Tenny Mudianto, Li Tan, Takeshi Shimamura, Matthew Meyerson, Adam J. Bass, Hideo Watanabe, Nathanael S. Gray, Richard A. Young, Kwok-Kin Wong, Peter S. Hammerman
Journal: Cancer Discovery (2017)

Abstract Acquired drug resistance is a major factor limiting the effectiveness of targeted cancer therapies. Targeting tumors with kinase inhibitors induces complex adaptive programs that promote the persistence of a fraction of the original cell population, facilitating the eventual outgrowth of inhibitor-resistant tumor clones. We show that the addition of a newly identified CDK7/12 inhibitor, THZ1, to targeted therapy enhances cell killing and impedes the emergence of drug-resistant cell populations in diverse cellular and in vivo cancer models. We propose that targeted therapy induces a state of transcriptional dependency in a subpopulation of cells poised to become drug tolerant, which THZ1 can exploit by blocking dynamic transcriptional responses, promoting remodeling of enhancers and key signaling outputs required for tumor cell survival in the setting of targeted therapy. These findings suggest that the addition of THZ1 to targeted therapies is a promising broad-based strategy to hinder the emergence of drug-resistant cancer cell populations. Significance: CDK7/12 inhibition prevents active enhancer formation at genes, promoting resistance emergence in response to targeted therapy, and impedes the engagement of transcriptional programs required for tumor cell survival. CDK7/12 inhibition in combination with targeted cancer therapies may serve as a therapeutic paradigm for enhancing the effectiveness of targeted therapies. Cancer Discov; 8(1); 59–73. ©2017 AACR. See related commentary by Carugo and Draetta, p. 17. This article is highlighted in the In This Issue feature, p. 1
Plasmacytoid dendritic cells drive acute asthma exacerbations
Authors: Aikaterini-Dimitra Chairakaki, Maria-Ioanna Saridaki, Katerina Pyrillou, Marios-Angelos Mouratis, Ourania Koltsida, Ross P. Walton, Nathan W. Bartlett, Athanasios Stavropoulos, Louis Boon, Nikoletta Rovina, Nikolaos G. Papadopoulos, Sebastian L. Johnston, Evangelos Andreakos
Journal: Journal of Allergy and Clinical Immunology (2017)
La utilización de la vigilancia centinela para estudiar la eficacia de la vacuna antigripal : un estudio piloto en Dinamarca
Authors: A Mazick, A H Christiansen, S Samuelsson, K Mølbak
Journal: Eurosurveillance (2006)

La vacuna antigripal de la temporada 2003/04 no incluia la cepa viral A(H3N2)/Fujian en circulacion. Aunque hubieran sido necesarios, no se disponia de estudios de evaluacion de la eficacia vacunal (EV). Por ese motivo, se planteo la posibilidad de utilizar el sistema de vigilancia de la gripe basado en los laboratorios para realizar dicha evaluacion. Se realizo un estudio caso-control en el sistema de vigilancia centinela danes. Se definio caso como una persona de 25 anos o mas con una gripe A(H3N2)/Fujian/411/02. Fueron seleccionados cuatro controles por caso, apareados por grupos de edad y fecha, entre los pacientes de los medicos centinela (MC) que habian declarado casos. Estos medicos recogieron, por medio de cuestionarios estructurados de una pagina, la informacion siguiente: estatus vacunal, enfermedades cronicas y vacunas antineumococicas. Se enviaron cuestionarios por correo a los medicos participantes para estimar la aceptabilidad y la sencillez de la recogida de datos. 
Se identificaron 24 casos. Se analizaron datos de 19 grupos casos-controles. Un control fue excluido por falta de informacion sobre su estatus vacunal. Dos de los 19 casos y 11 de los 75 controles habian sido vacunados contra la gripe. La EV ajustada para las enfermedades cronicas fue del 33% (95% IC 0%–88%) y del 37% (95% IC 0%–89%) excluyendo cinco controles con sindrome gripal. Veintidos medicos devolvieron el cuestionario. Quince medicos de 17 no tuvieron dificultades en encontrar controles. Los medicos recogieron los datos mediante entrevistas con los pacientes y notas clinicas, dedicando de 1 a 5 minutos para cada caso y de 5 a 15 minutos para los cuatro controles. Diez y nueve de los 22 MC estimaron aceptable el tiempo dedicado a la encuesta, 17 dijeron que les gustaria volver a participar, y ninguno desecho la idea de una futura colaboracion. 
Este estudio demuestra que el control de la EV en los sistemas de vigilancia centinela es viable, si bien el escaso numero de casos limita la interpretacion de los resultados. Un estudio a escala europea con varios paises, superaria esta limitacion, y podria ofrecer evaluaciones de la eficacia vacunal de forma mas precoz en la temporada, para diferentes grupos de edad y para cepas virales emergentes, incluyendo sub-tipos nuevos y pandemicos.