tbuckley/cabot-search huggingface dataset:
Is stereotactic radiosurgery of brain metastases in patients with poor performance status worthwhile?
Authors: Federico Ampil, Donghyun Kim, Troy Richards, Moiz Vora, Glenn Morris Mills, Anil Nanda
Journal: Journal of Clinical Oncology (2017)

192 Background: Performance status is a consistent predictor of outcome in people with advanced disease. Variable prognosis has not led to the exclusion of patients with Karnofsky performance scores of &lt; 70 from treatment of brain metastases (BRM) with stereotactic radiosurgery (SRS). The role of SRS for BRM in individuals with poor performance status (PPS) has not been elucidated to date. To better understand the prognostic utility of SRS in this particular patient cohort, we assessed the longevity periods of our treated PPS subjects with BRM. Methods: A retrospective review of patients with BRM treated by SRS during a 10-year period (2000-2009) identified 22 adult individuals with PPS; PPS was defined by the presence of severe hemiparesis or cerebellar ataxia. The primary endpoint of the analysis was survival because of some limitations in the obtained data. The mean follow-up was 26 months (range: &lt; 1 to 144 months). Results: The mean age was 55.8 years, and the majority of the subjects were female. Most of the patients were younger and diagnosed with solitary brain metastasis. The synchronous primary malignant tumor was not yet under control in a third of the patients, and extracranial metastases were noted in 45% of the subjects. Thirteen people (59%) died within two months after therapy, and nine patients (41%) lived for two years or longer. The overall crude survival rates at 1 year and 5 years were 41% and 18%, respectively. Treatment response information was not available in the short-survival group because of early demise. Intracranial tumor control was achieved in the long-term survivors, considering that BRM progression requiring repeat SRS was not observed in any instance. Characterization of the two groups with different longevities was not possible. Conclusions: Early mortality was not predominant in this limited experience, and the observed prolonged survival suggests that SRS still represents a valuable treatment option for individuals with PPS and BRM.
Outcomes of vulvar cancer (VC) patients (pts): Impact of clinicopathological factors and HPV status
Authors: C. Ortiz, V. Rodriguez Freixinos, J. Hernandez-Losa, L. FariÑas Madrid, A. Gil- Moreno, A. Pérez Benavente, J.L. Sanchez-iglesias, B. Díaz-Feijo, A. Garcia, S. Franco-Camps, S. Cabrera-Diaz, R. Verges, C. Viaplana, G. Villacampa-Javierre, R. Dienstmann, A. Oaknin
Journal: Annals of Oncology (2017)
Shared understanding: Predicting home hospice nurse-cancer family caregiver communication similarity.
Authors: Maija Reblin, Lauren Kane, Brian R Baucom, Margaret F. Clayton, Lee Ellington
Journal: Journal of Clinical Oncology (2017)

40 Background: In cancer home hospice, families provide 24/7 care with support from a nurse-led hospice team. Effective patient-caregiver-nurse communication can facilitate a “shared understanding,” resulting in better patient caregiver outcomes. Shared understanding may be evidenced by high similarity in language usage/meaning. Objective: Describe communication caregiver-nurse similarity (relatedness in word usage/meaning) in cancer home hospice using latent semantic analysis (LSA) and to identify nurse communication processes, confidence, and preferences that predict communication similarity. Methods: As part of a larger study, nurse home hospice visits to spouse cancer caregivers were audio recorded. Interaction analysis was used to quantify caregiver and nurse emotion talk, nurse partnering, and nurse dominance (ratio of total nurse/caregiver talk). Nurses completed questionnaires to capture preference for patient oriented care and confidence in their communication. Verbatim transcripts were analyzed using LSA, a tool that assesses the similarity of communication (range 0-1 where higher scores indicate greater similarity). Descriptive statistics and bivariate correlations were calculated. Results: 31 nurse-caregiver home hospice interactions were analyzed. Nurses were female, average age 44.03 (SD = 9.8), with an average 14.6 years experience. Spouse caregivers were 77% female, average age 64.7 (SD = 10.9). The average LSA score was .83 (range = .66-.89). Higher LSA values were significantly associated with more nurse partnering (r = .36, p = .05) and lower nurse dominance (r = -.39, p = .03), but not caregiver or nurse emotion talk (ps &gt; .05). Higher LSA values also predicted more nurse-reported preference for patient-oriented care (r = -.75, p &lt; .01) and lower nurse communication confidence (r = -.46, p = .01). Conclusions: Our findings suggest that hospice nurses who are more patient-oriented, listen to and encourage caregivers’ concerns are more likely to use concordant meaning and language usage in their home hospice visits. Further research should examine if a nurse’s use of language similarity strategies improve caregiver understanding, competency and satisfaction with care.
Smoke-Free Policies in the World’s 50 Busiest Airports — August 2017
Authors: Michael A. Tynan, Elizabeth Reimels, Jennifer Tucker, Brian A. King
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Exposure to secondhand smoke from burning tobacco products causes premature death and disease, including coronary heart disease, stroke, and lung cancer among nonsmoking adults and sudden infant death syndrome, acute respiratory infections, middle ear disease, exacerbated asthma, respiratory symptoms, and decreased lung function in children (1,2). The U.S. Surgeon General has concluded that there is no risk-free level of exposure to secondhand smoke (1). Previous CDC reports on airport smoke-free policies found that most large-hub airports in the United States prohibit smoking (3); however, the extent of smoke-free policies at airports globally has not been assessed. CDC assessed smoke-free policies at the world's 50 busiest airports (airports with the highest number of passengers traveling through an airport in a year) as of August 2017; approximately 2.7 billion travelers pass through these 50 airports each year (4). Among these airports, 23 (46%) completely prohibit smoking indoors, including five of the 10 busiest airports. The remaining 27 airports continue to allow smoking in designated smoking areas. Designated or ventilated smoking areas can cause involuntary secondhand smoke exposure among nonsmoking travelers and airport employees. Smoke-free policies at the national, city, or airport authority levels can protect employees and travelers from secondhand smoke inside airports.
Association of Salivary MicroRNA Changes With Prolonged Concussion Symptoms
Authors: Jeremiah J. Johnson, Andrea C. Loeffert, Jennifer Stokes, Robert P. Olympia, Harry Bramley, Steven D. Hicks
Journal: JAMA Pediatrics (2017)

Approximately one-third of children who experience a concussion develop prolonged concussion symptoms. To our knowledge, there are currently no objective or easily administered tests for predicting prolonged concussion symptoms. Several studies have identified alterations in epigenetic molecules known as microRNAs (miRNAs) following traumatic brain injury. No studies have examined whether miRNA expression can detect prolonged concussion symptoms.To evaluate the efficacy of salivary miRNAs for identifying children with concussion who are at risk for prolonged symptoms.This prospective cohort study at the Penn State Medical Center observed 52 patients aged 7 to 21 years presenting for evaluation of concussion within 14 days of initial head injury, with follow-up at 4 and 8 weeks.All patients had a clinical diagnosis of concussion.Salivary miRNA expression was measured at the time of initial clinical presentation in all patients. Patients with a Sport Concussion Assessment Tool (SCAT3) symptom score of 5 or greater on self-report or parent report 4 weeks after injury were designated as having prolonged symptoms.Of the 52 included participants, 22 (42%) were female, and the mean (SD) age was 14 (3) years. Participants were split into the prolonged symptom group (n = 30) and acute symptom group (n = 22). Concentrations of 15 salivary miRNAs spatially differentiated prolonged and acute symptom groups on partial least squares discriminant analysis and demonstrated functional relationships with neuronal regulatory pathways. Levels of 5 miRNAs (miR-320c-1, miR-133a-5p, miR-769-5p, let-7a-3p, and miR-1307-3p) accurately identified patients with prolonged symptoms on logistic regression (area under the curve, 0.856; 95% CI, 0.822-0.890). This accuracy exceeded accuracy of symptom burden on child (area under the curve, 0.649; 95% CI, 0.388-0.887) or parent (area under the curve, 0.562; 95% CI, 0.219-0.734) SCAT3 score. Levels of 3 miRNAs were associated with specific symptoms 4 weeks after injury; miR-320c-1 was associated with memory difficulty (R, 0.55; false detection rate, 0.02), miR-629 was associated with headaches (R, 0.47; false detection rate, 0.04), and let-7b-5p was associated with fatigue (R, 0.45; false detection rate, 0.04).Salivary miRNA levels may identify the duration and character of concussion symptoms. This could reduce parental anxiety and improve care by providing a tool for concussion management. Further validation of this approach is needed.
Genome-Wide Genotype-Based Risk Model for Survival in Core Binding Factor Acute Myeloid Leukemia Patients
Authors: Silvia Park, Choi Hangseok, Hee-Je Kim, Jae-Sook Ahn, Hyeoung Joon Kim, Sung-Hyun Kim, Yeung-Chul Mun, Chul Won Jung, Dong Hwan Kim
Journal: Blood (2016)
Abstract 16678: Classification of Cardiovascular Proteins Involved in Coronary Atherosclerosis and Heart Failure Using Watson’s Cognitive Computing Technology
Authors: Christian T Ruff, Alix Lacoste, Francesco Nordio, Christina L Fanola, Michael G Silverman, Elenee Argentinis, Scott Spangler, Marc S Sabatine
Journal: Circulation (2017)

Introduction: Big data has the potential to deliver on the promise of personalized medicine by using sophisticated machine learning and other advanced analytic techniques to extract important insig...
EAST-LC: Randomized controlled phase III trial of S-1 versus docetaxel (DOC) in patients with non-small cell lung cancer (NSCLC) who had received a platinum-based treatment: Results from patient-reported outcomes (PROs)
Authors: R. Soo, T.S.K. Mok, Y-K Shi, L. Zhang, S. Lu, J C-H Yang, K. Nakagawa, N. Yamamoto, H. Nokihara, S. Sugawara, M. Nishio, T. Takahashi, K. Goto, J. Chang, M. Maemondo, Y. Ichinose, Y. Cheng, W. Lim, S. Morita, T. Tamura
Journal: Annals of Oncology (2017)
Can we predict the clinical outcome of arthroscopic partial meniscectomy? A systematic review
Authors: Susanne M Eijgenraam, Max Reijman, Sita M A Bierma-Zeinstra, Daan T van Yperen, Duncan E Meuffels
Journal: British Journal of Sports Medicine (2017)

NHS-Prospero registration number 42016048592 Objective In order to make a more evidence-based selection of patients who would benefit the most from arthroscopic partial meniscectomy (APM), knowledge of prognostic factors is essential. We conducted a systematic review of predictors for the clinical outcome following APM. Design Systematic review Data sources Medline, Embase, Cochrane Central Register, Web of Science, SPORTDiscus, PubMed Publisher, Google Scholar Inclusion criteria Report an association between factor(s) and clinical outcome; validated questionnaire; follow-up &gt;1 year. Exclusion criteria &lt;20 subjects; anterior cruciate ligament-deficient patients; discoid menisci; meniscus repair, transplantation or implants; total or open meniscectomy. Methods One reviewer extracted the data, two reviewers assessed the risk of bias and performed a best-evidence synthesis. Results Finally, 32 studies met the inclusion criteria. Moderate evidence was found, that the presence of radiological knee osteoarthritis at baseline and longer duration of symptoms (&gt;1 year) are associated with worse clinical outcome following APM. In addition, resecting &gt;50% of meniscal tissue and leaving a non-intact meniscal rim after meniscectomy are intra-articular predictive factors for worse clinical outcome. Moderate evidence was found that sex, onset of symptoms (acute or chronic), tear type or preoperative sport level are not predictors for clinical outcome. Conflicting evidence was found for the prognostic value of age, perioperative chondral damage, body mass index and leg alignment. Summary/conclusion Long duration of symptoms (&gt;1 year), radiological knee osteoarthritis and resecting &gt;50% of meniscus are associated with a worse clinical outcome following APM. These prognostic factors should be considered in clinical decision making for patients with meniscal tears.
Surveillance sentinelle de l'infection à VIH dans des cliniques de dépistage du VIH en Espagne, 1992-2002
Authors: A Barrasa, J Castilla, J del Romero, I Pueyo, C de Armas, J A Varela, J M Ureña, F J Bru, J R Ordoñana, L M Sáez de Vicuña
Journal: Eurosurveillance (2004)

En Espagne, l'infection a VIH a ete evaluee a partir des personnes ayant subi, entre 1992 et 2002, un test volontaire de depistage du VIH dans 10 cliniques sentinelle. Seules les personnes pour qui il s'agissait d'un premier test ont ete inclues, soit 4426 en 1992 et 6649 en 2002. La plupart etaient des heterosexuels reconnaissant avoir eu des conduites a risques. Dans la population etudiee, la proportion d'utilisateurs de drogues injectables (UDI) a diminue de 19% a 2%, et la proportion de travailleuses du sexe a augmente de 6% a 26%. Le nombre de patients presentant un diagnostic positif a diminue de 604 en 1992 a 153 en 2002, de meme que la prevalence du VIH qui est passee de 13,6% a 2,3% pour la meme periode. La baisse de la prevalence du VIH, observee quelle que soit la categorie a risque d'exposition, a ete plus marquee les premieres annees puis s'est stabilisee les dernieres annees. En 2002, la prevalence la plus elevee a ete retrouvee chez les UDI (14,2%), les homo/bisexuels masculins (7,5%) et les personnes ayant eu un partenaire heterosexuel infecte par le VIH (10,2%).
Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection
Authors: Ke Xu, Chen Xu, Yanzhenzi Zhang, Feiran Qi, Bingran Yu, Ping Li, Lixin Jia, Yulin Li, Fu-jian Xu, Jie Du
Journal: Theranostics (2017)

Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is initially exposed followed by endothelial injury as early-stage event of TAD. So, we want to build a noninvasive diagnostic method to detect early dissection by identifying the exposed Col-IV via MRI.
Abstract 10380: The Ashman Phenomenon in Patients With Atrial fibrillation Treated With an IKr Blocker, Dofetilide
Authors: M. Rizwan Sardar, Amanullah Khaji, Jul Robert, Jason T Bradley, Ganxin Yan
Journal: Circulation (2013)

Introduction: The Ashman phenomenon is aberrant ventricular conduction that often occurs during a short-long-short R-R interval in patients with atrial fibrillation. The aberrant conduction is caus...
What structural priming can and cannot reveal
Authors: Loes Koring, Eric Reuland
Journal: Behavioral and Brain Sciences (2017)

Abstract The nature of mental representations of linguistic expressions in relation to the time course from intention to articulation is a major issue. We discuss Branigan &amp; Pickering's (B&amp;P's) proposal to use structural priming to tap into this process. We show that their interpretation of their findings cannot be maintained. We reinterpret these results and suggest a revision of their conclusions.
PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth
Authors: Natalia Martín-Martín, Amaia Zabala-Letona, Sonia Fernández-Ruiz, Leire Arreal, Laura Camacho, Mireia Castillo-Martin, Ana R. Cortazar, Verónica Torrano, Ianire Astobiza, Patricia Zúñiga-García, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Miguel Unda, Lorea Valcárcel-Jiménez, Amaia Arruabarrena-Aristorena, Marco Piva, Pilar Sánchez-Mosquera, Ana M. Aransay, Antonio Gomez-Muñoz, Rosa Barrio, James D. Sutherland, Arkaitz Carracedo
Journal: Cancer Research (2017)

The nuclear receptor PPAR-β/δ (PPARD) has essential roles in fatty acid catabolism and energy homeostasis as well as cell differentiation, inflammation, and metabolism. However, its contributions to tumorigenesis are uncertain and have been disputed. Here, we provide evidence of tumor suppressive activity of PPARD in prostate cancer through a noncanonical and ligand-independent pathway. PPARD was downregulated in prostate cancer specimens. In murine prostate epithelium, PPARD gene deletion resulted in increased cellularity. Genetic modulation of PPARD in human prostate cancer cell lines validated the tumor suppressive activity of this gene in vitro and in vivo Mechanistically, PPARD exerted its activity in a DNA binding-dependent and ligand-independent manner. We identified a novel set of genes repressed by PPARD that failed to respond to ligand-mediated activation. Among these genes, we observed robust regulation of the secretory trefoil factor family (TFF) members, including a causal and correlative association of TFF1 with prostate cancer biology in vitro and in patient specimens. Overall, our results illuminate the oncosuppressive function of PPARD and understanding of the pathogenic molecular pathways elicited by this nuclear receptor.Significance: These findings challenge the presumption that the function of the nuclear receptor PPARβ/δ in cancer is dictated by ligand-mediated activation. Cancer Res; 78(2); 399-409. ©2017 AACR.
An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study
Authors: Toby M Maher, Eunice Oballa, Juliet K Simpson, Joanne Porte, Anthony Habgood, William A Fahy, Aiden Flynn, Philip L Molyneaux, Rebecca Braybrooke, Hrushikesh Divyateja, Helen Parfrey, Doris Rassl, Anne-Marie Russell, Gauri Saini, Elisabetta A Renzoni, Anne-Marie Duggan, Richard Hubbard, Athol U Wells, Pauline T Lukey, Richard P Marshall, R Gisli Jenkins
Journal: The Lancet Respiratory Medicine (2017)
Abstract 16793: Postoperative Acetaminophen Dose is Associated With Lower Rate of Acute Kidney Injury After Cardiac Surgery and Cardiopulmonary Bypass
Authors: Leon Darghosian, Yaping Shi, Leena Choi, Andrew H Smith, Edmund H Jooste, Kevin D Hill, Prince J Kannankeril, Lorraine B Ware, Sara L Van Driest
Journal: Circulation (2017)

Introduction: Half of all pediatric cardiac surgery (CS) patients develop postoperative acute kidney injury (AKI), which is associated with increased mortality, morbidity, and length of stay. CS an...
From Sgt. Pepper to Dreamachines: My Scientific Odyssey With William S. Burroughs
Authors: Andrew J. Lees
Journal: JAMA (2017)

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Cytotoxic gene therapy of esophageal cancers using the recombinant RGD-modified adenovirus expressing membrane-bound TRAIL (TNF-Related Apoptosis-Inducing Ligand): an in vitro and in vivo analysis
Authors: Wen-Shuz Yeow, Alex Chua, Duc M. Nguyen, Shailen Sehgal, Bingliang Fang, David S. Schrump, Dao M. Nguyen
Journal: Cancer Research (2006)

2994  Objective: Esophageal cancers are potentially amenable to gene therapy via direct intratumoral injection of therapeutic vectors using endoscopic approach. We aimed to evaluate the tumoricidal effect of the RGD-modified adenovirus expressing TRAIL under the tumor-selective hTERT promoter (AdV-RGD/TRAIL) with and without CDDP pretreatments in a panel of 4 esophageal cancer (EsC) cells. Methods: EsC cells, TE2, TE12, SK4 and SEG1, were transduced with AdV-RGD/TRAIL or, AdV-RGD/GFP or AdV-hTERT/LacZ as vector controls, at 1 to 10 pfu (plaque forming unit)/cell ± 1 μg/ml CDDP pre-treatment. MTT, Annexin V and TUNEL assays measured cell viability and apoptosis. Subcutaneous SK4 EsC xenografts were created in nude mice. Direct intratumoral injections of adenoviral vectors (4.4x108 pfu/injection every 3 days x 3; ± intraperitoneal 4 mg/kg CDDP one day before virus administration) were started when tumors reached 40-60 mm3. Results: RGD/TRAIL mediated a dose-dependent reduction of cell viability in EsC cells that was most pronounced in SEG1 and SK4. CDDP, while conferring additive cytotoxicity in SEG1 and SK4 cells, synergistically potentiated the antitumor effect of this virus in the resistant TE2 and TE12 cells (Figure A). Similarly, significant additive or synergistic apoptosis was also observed in combination-treated cells (TE12: RGD/TR (5pfu/cell): 11±6% apoptosis, CDDP: 10±4%, combination: 55±6%; SEG1 RGD/TR: 42±14%, CDDP: 4±2%, combination: 48±8%; n=3, p