Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk
Authors: Johanna M. Geleijnse, Ingeborg A. Brouwer, Daan Kromhout
Journal: Annals of Internal Medicine (2014)

Letters16 September 2014Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary RiskJohanna M. Geleijnse, PhD, Ingeborg A. Brouwer, PhD, MSc, and Daan Kromhout, PhD, MScJohanna M. Geleijnse, PhDFrom Wageningen University, Wageningen, the Netherlands; VU University Amsterdam, Amsterdam, the Netherlands; and Wageningen University, Wageningen, the Netherlands.Search for more papers by this author, Ingeborg A. Brouwer, PhD, MScFrom Wageningen University, Wageningen, the Netherlands; VU University Amsterdam, Amsterdam, the Netherlands; and Wageningen University, Wageningen, the Netherlands.Search for more papers by this author, and Daan Kromhout, PhD, MScFrom Wageningen University, Wageningen, the Netherlands; VU University Amsterdam, Amsterdam, the Netherlands; and Wageningen University, Wageningen, the Netherlands.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5018-9 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Chowdhury and colleagues (1) reported no association between SFA and coronary risk, thereby casting doubt on cardiovascular guidelines that advocate increased intake of PUFA at the former's expense. The review examined SFA, MUFA, and PUFA as separate entities. This method, however, is flawed because the health effect of a macronutrient that delivers a substantial amount of daily calories, such as SFA, cannot be studied in isolation but depends on whether other macronutrients are replaced.Saturated fats are beneficial when they replace trans fatty acids (2). We also know that replacing them with carbohydrates (i.e., a low-fat diet ...References1. Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med. 2014;160:398-406. [PMID: 24723079] doi:10.7326/M13-1788 LinkGoogle Scholar2. Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr. 2003;77:1146-55. [PMID: 12716665] CrossrefMedlineGoogle Scholar3. Kromhout D, Geleijnse JM, Menotti A, Jacobs DR. The confusion about dietary fatty acids recommendations for CHD prevention. Br J Nutr. 2011;106:627-32. [PMID: 21733329] doi:10.1017/S0007114511002236 CrossrefMedlineGoogle Scholar4. Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ. 2013;346:e8707. [PMID: 23386268] doi:10.1136/bmj.e8707 CrossrefMedlineGoogle Scholar5. Jakobsen MU, O’Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, et al. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr. 2009;89:1425-32. [PMID: 19211817] doi:10.3945/ajcn.2008.27124 CrossrefMedlineGoogle Scholar6. Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med. 2010;7:e1000252. [PMID: 20351774] doi:10.1371/journal.pmed.1000252 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Wageningen University, Wageningen, the Netherlands; VU University Amsterdam, Amsterdam, the Netherlands; and Wageningen University, Wageningen, the Netherlands.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0321. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAssociation of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Rajiv Chowdhury , Samantha Warnakula , Setor Kunutsor , Francesca Crowe , Heather A. Ward , Laura Johnson , Oscar H. Franco , Adam S. Butterworth , Nita G. Forouhi , Simon G. 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Jacobson Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lisa Te Morenga , Jim Mann , and Murray Skeaff Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Lukas Schwingshackl and Georg Hoffmann Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk Connie Diekman , Gerard Hornstra , Bethold V. Koletzko , Anna Lartey , and Joyce Nettleton Metrics Cited ByNew Insights or Confusion—Is Butter Really Back? 16 September 2014Volume 161, Issue 6Page: 457-458KeywordsDietFatsFatty acidsHypercholesterolemiaNutrientsProspective studiesRisk management ePublished: 16 September 2014 Issue Published: 16 September 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...