tbuckley/cabot-search huggingface dataset:
THU0148 Increase of night qt-interval duration in rheumatoid arthritis patients treated with tofacitinib during 12-month follow-up
Authors: IG Kirillova, D Novikova, E Luchikhina, E Markelova, H Udachkina, N Demidova, A Misiyuk, T Popkova, A Volkov, L Denisov, D Karateev
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Objectives</h3> to evaluate dynamic of ECG parameters in RA pts treated with tofacitinib (TOFA) during 12-month follow-up. <h3>Methods</h3> After 12-m follow-up the ECG parameters by 12 lead ECG and 24h ECG was assessed in 28 RA pts treated with TOFA (22 women, median age 54 [40;62] years, disease duration 39,5 [16,5;60,0] m, moderate to high activity (DAS28–5.1 [4.6;6.0], SDAI–26 (21;34)), positive for ACCP (75%)/RF (79%), who were non-responders to MTX at least 15 mg/week and/or other synthetic DMARDs and bDMARDs. TOFA therapy was started in all pts with dose 5 mg BID per os followed by the dose escalation to 10 mg BID in 8 (29%) pts. TOFA used in combination with MTX in 27 (96%) pts, leflunomide in 1 (4%). Low-dose oral corticosteroids (&lt;10 mg/day prednisone or equivalent) were received by 9 (35%) pts. Remission or LDA was achieved in 55% pts (DAS28), 77% (SDAI). At baseline the most of pts had multiple CVRF and subclinical organ damage (arterial hypertension-67%, overweight-57%, abdominal obesity-61%, physical inactivity-64%, smokers/ex-smokers-25%/21%, menopausal status-59%, DM type 2–7%, mSCORE≥5%&gt;21%, subclinical carotid atherosclerosis-64%, cardiac heart failure with preserved ejection fraction-7%. Cardioprotective therapy received 16 (57%) pts (beta-blockers–7, angiotensin II receptor type 2/ACE inhibitors–11, statins–11, dihydropyridine calcium channel blockers-7). <h3>Results</h3> There was no difference in heart rate (HR), QTc interval duration, QRS duration measured by 12-lead ECG in RA pts treated with TOFA (table 1). However, an increase in PQ interval duration was observed (p=0,04). There were significantly decrease of mean HR (p&lt;0,003), increase of QRS duration (p&lt;0,03), QTc (p&lt;0.03), night QTc (p&lt;0,02) in 24 h ECG ambulatory recording. HR, PQ, QTc duration were changed independently of beta-blockers therapy. The number of pts with QTc≥440 ms increased from 11% to 21% (p&gt;0.05). A change in QTc duration correlated negatively with dynamics of DAS 28, SDAI (r=-0,4, p&lt;0,05), DM (r=0,5, p&lt;0,02), dBP (r=-0,4, p&lt;0,04). There were also significantly increase number of ventricular premature beats (p&lt;0,03). <h3>Conclusions</h3> A significant decrease in HR and an increase in QRS, night QTc interval duration, number of ventricular premature beats by 24h ECG were observed in RA pts treated with tofacitinib (TOFA) during 12-month follow-up. QTc duration correlated with dynamic of disease activity, DM type 2 and diastolic BP. <h3>Disclosure of Interest</h3> None declared
SAT0323 The endothelial-to-mesenchymal transition (ENDOMT) in scleroderma can be prevented by the use of dual endothelin receptor antagonists bosentan and macitentan
Authors: C Corallo, M Cutolo, S Soldano, A Montella, C Chirico, R Nuti, N Giordano
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Systemic sclerosis (SSc) is characterized by early vascular abnormalities and subsequent fibroblast activation and differentiation into myofibroblasts, leading to fibrosis. Recently, endothelial-to-mesenchymal transition (EndoMT), a complex biological process in which endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic phenotype, has been reported in SSc. <h3>Objectives</h3> The goal of the study was to evaluate the potential of endothelin-1 (ET-1) dual receptor antagonists bosentan (BOS) and macitentan (MAC) to antagonize EndoMT <i>in vitro</i>. <h3>Methods</h3> 20 patients with limited SSc were enrolled and underwent double skin biopsy (affected and nonaffected skin). Fibroblasts and microvascular endothelial cells (MVECs) were isolated from biopsies. Mono- or coculture of MVECs (isolated from nonaffected skin) with fibroblasts (isolated from affected skin and stimulated with ET-1 and transforming growth factor beta [TGF-β]) were performed. In cocultures, the MVEC layer was left undisturbed or was preincubated with either BOS or MAC. After 48 h of coculture, MVECs were analyzed for their capillary formation ability and for messenger RNA and protein expression of different vascular (CD31, vascular endothelial growth factor-A [VEGF-A], VEGF-A165b) and profibrotic (alpha-smooth muscle actin [α-SMA], collagen type I [Col I], TGF-β) molecules. <h3>Results</h3> MVECs showed a reduced capillary formation ability when cocultured with SSc fibroblasts with respect to mono cultures. CD31 and VEGF-A resulted in downregulation, while VEGF-A165b, the antiangiogenic isoform, resulted in upregulation. At the same time, mesenchymal markers α-SMA, Col I, and TGF-β resulted in overexpression in MVECs. Capillary formation ability was restored when MVECs were preincubated with BOS or MAC, also reducing the expression of mesenchymal markers and restoring CD31 expression as well as the imbalance between VEGF-A and VEGF-A165b. <h3>Conclusions</h3> BOS and MAC seem able to antagonize EndoMT phenomenon in MVECs <i>in vitro</i>. Blocking EndoMT is important for two reasons: first, because capillary formation ability in MVECs can be restored; second, because the endothelium-derived fibrotic development in SSc can be counteracted. <h3>Acknowledgements</h3> Thanks to Prof. Bashar Kahaleh and to Dr. Yongqing Wang from University of Toledo Medical Center, Division of Rheumatology and Immunology, OH, USA, for providing SSc microvascular endothelial cells. <h3>Disclosure of Interest</h3> None declared
Activity and safety of crizotinib in patients with advanced clear-cell sarcoma with MET alterations: European Organization for Research and Treatment of Cancer phase II trial 90101 ‘CREATE’
Authors: P. Schöffski, A. Wozniak, S. Stacchiotti, P. Rutkowski, J.-Y. Blay, L.H. Lindner, S.J. Strauss, A. Anthoney, F. Duffaud, S. Richter, V. Grünwald, M.G. Leahy, P. Reichardt, J. Sufliarsky, W.T. van der Graaf, R. Sciot, M. Debiec-Rychter, T. van Cann, S. Marréaud, M. Lia, T. Raveloarivahy, L. Collette, S. Bauer
Journal: Annals of Oncology (2017)
AB0933 Predictive model for shoulder pain using clinical and epidemiological variables
Authors: C Feced Olmos, E Sánchez Labrador, J Ivorra Cortes, E Grau Garcia, E Vicens Bernabeu, JJ Fragio Gil, R Mazarío González, C Alcañiz Escandell, I Cánovas Olmos, I Chalmeta Verdejo, L Gonzalez Puig, I Martínez Cordellat, C Nájera Herranz, R Negueroles Albuixech, JE Oller Rodriguez, FM Ortiz-Sanjuan, D Marín Hervás, JA Román Ivorra
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Shoulder pain is a very common complaint with poor prognosis and high recurrence. To evaluate the shoulder pain, anamnesis and physical examination are used, but a diagnosis of certainty is difficult. Clinical history and specific exploration maneuvers tend to be poorly correlated with the underlying problem. There are few studies that assess the predictability of shoulder pathology using patient characteristics and exploration. <h3>Objectives</h3> To assess if the combination of exploratory maneuvers and clinical data predicts the type of affection of the painful shoulder in a sensitive and specific way. <h3>Methods</h3> We conducted a prospective study with patients who attended to the Rheumatology Department of HUP La Fe by painful shoulder between February 2016 and January 2017, excluding those with known inflammatory diseases. A rheumatologist performed the anamnesis and the selected exploratory maneuvers: Jobe and Gerber test and palpation of the acromioclavicular joint. A second rheumatologist, blind to physical examination and medical history, performed the shoulder ultrasound scan. Biostatistic analysis was performed using software R version 3.3.2. <h3>Results</h3> 119 patients (66.4% women) with a mean age of 60±12.56 years and shoulder pain were collected. Time of pain evolution was 20.43±24.09 months and the right shoulder was the most affected one (71.4%). The association between the maneuvers of Jobe and the involvement of the supraspinatus (SE), as well as the Gerber maneuver with the affectation of the subscapular were statistically significant. However the sensitivity and specificity of both maneuvers are very low, so that alone is not suitable to identify the affected tendon or the type of alteration. Thus, a predictor model (nomogram) of the most common shoulder pathologies (subacromiodeltoid bursitis, tendinosis or SE tears) was developed using epidemiological and clinical examination variables. <h3>Conclusions</h3> Based on our results, the predictor model performed using epidemiological and clinical examination variables would be able to predict the most frequent pathologies of the shoulder. Imaging tests have a certain delay time, and by applying this predictor model, a diagnosis of presumption could be established in primary care, giving the opportunity to institute an early treatment. In addition, patients could be referred more efficiently to the appropriate specialty (rheumatology, traumatology or rehabilitation), avoiding delays. <h3>Disclosure of Interest</h3> None declared
AB1179 Can the patients with total knee arthroplasty achieve discharge criteria for knee flexion
Authors: C Sevinc, A Arik, S Onal, V Bayrakci Tunay
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> Knee range of motion (ROM) at discharge following total knee arthroplasty is used as a clinical indicator of performance. At least 90 degrees of flexion is standard discharge criteria for many hospitals. <h3>Objectives</h3> To investigate whether the discharge criteria is realistic in patients with TKA. <h3>Methods</h3> 13 patients (11=female, 2=male) who underwent unilateral TKA were included in this study. Mean age was 68.46±7.52 years, mean body mass index (BMI) was 30.14±5.6 kg/m<sup>2</sup>. Hospitalization duration was recorded. Knee flexion and extension degree were measured actively with goniometer during heel sliding on discharge day. Oxford Knee Score (OKS) was used to evaluate physical function and pain before surgery. Overall scores ranges from 0 (worst) to 48 (best). Descriptive statistics were used to analyse the data using SPSS v22. <h3>Results</h3> Hospitalization duration was 5.07±1.25 days. Knee flexion degree and knee extension limitation were found 79.15±20.84° and 12.92±7.31°, respectively. Oxford Knee Score was calculated 19±8.30 point. Patients9 results were given at Table 1. <h3>Conclusions</h3> Patients have noticeable extension limitations at discharge. It should follow in the upcoming days. Nearly half of the patients flexed their knee less than expected. Due to the fact that discharge criteria for knee flexion is unrealistic. It should be investigate whether patients with less knee flexion degree can gain function as patients with more knee flexion degree. <h3>References</h3> Husted, Henrik, et al. Traditions and myths in hip and knee arthroplasty: A narrative review. Acta orthopaedica 85.6 (2014): 548–555. Naylor, Justine M., et al. Is discharge knee range of motion a useful and relevant clinical indicator after total knee replacement? Part 1. Journal of evaluation in clinical practice 18.3 (2012): 644–651. <h3>Disclosure of Interest</h3> None declared
Anti-Thymocyte Globulin for Graft-Versus-Host Disease Prophylaxis in Patients with Acute Myeloid Leukemia Undergoing Reduced Intensity Conditioning Allogeneic Stem Cell Transplantation in First Complete Remission: A Survey on Behalf of the EBMT Acute Leukemia Working Party
Authors: Yishai Ofran, Eric Beohou, Myriam Labopin, Didier Blaise, Jan J. Cornelissen, Marco R De Groot, Gerard Socié, Anne Huynh, Johan Maertens, Frederic Baron, Mohamad Mohty, Arnon Nagler
Journal: Blood (2016)
OP0142-HPR The potential buffering role of self-efficacy and pain acceptance against invalidation in rheumatic diseases
Authors: R Geenen, N Cameron, MB Kool, F Estévez-Lόpez, I Lόpez-Chicheri
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> A substantial number of people with a rheumatic disease perceive invalidation consisting of "lack of understanding" and "discounting" (negative social responses) [1]. Our study was guided by the notion that high self-efficacy will make people feel competent to deal with situations in which control of invalidation is possible and likely to be successful. In other situations, high acceptance will help people to actively and in full awareness experience even adverse situations such as invalidation without unnecessary attempts to change their frequency or form, which is considered a core aspect of acceptance. <h3>Objectives</h3> To get insight into the potential buffering role of self-efficacy and pain acceptance against invalidation, we examined the association of self-efficacy and pain acceptance with invalidation in people with diverse rheumatic diseases. <h3>Methods</h3> The design was cross-sectional. Spanish speaking people (N=1153, 91% female, mean age 45±11 years) with one or multiple rheumatic diseases completed online versions of the Illness Invalidation Inventory [2], the Chronic Pain Acceptance Questionnaire, and the Chronic Disease Self-Efficacy Scale. <h3>Results</h3> Before and after adjustment for age, gender, education, and fibromyalgia diagnosis, higher self-efficacy and higher pain acceptance were independently associated with discounting and lower lack of understanding (<i>P</i>&lt;0.001, see Figure). The combined occurrence of high self-efficacy and high acceptance was associated most clearly with lower lack of understanding (interaction: <i>P</i>=0.03) and with discounting (interaction: <i>P</i>=0.07, not reaching statistical significance): see Figure. <h3>Conclusions</h3> The present study convincingly shows that self-efficacy and pain acceptance are associated with less invalidation. This suggests the usefulness of examining in prospective studies whether interventions aimed at increasing self-efficacy and pain acceptance can help people with rheumatic diseases for whom invalidation is a considerable burden. A cognitive-behavioral model including self-efficacy and acceptance to deal with invalidation is proposed. <h3>References</h3> Kool MB, van Middendorp H, Boeije HR, Geenen R. Understanding the lack of understanding: invalidation from the perspective of the patient with fibromyalgia. Arthritis Rheum-Arthritis Care Res 2009;61:1650–6. Kool MB, van Middendorp H, Lumley MA, Schenk Y, Jacobs JW, Bijlsma JW, Geenen R. Lack of understanding in fibromyalgia and rheumatoid arthritis: the Illness Invalidation Inventory (3*I). Ann Rheum Dis 2010;69:1990–5. <h3>Disclosure of Interest</h3> None declared
Incidental 131I Activity in the Deltoid Region on Posttherapy Radioiodine Scan
Authors: Mark D. Strober, Brandon R. Callahan
Journal: Clinical Nuclear Medicine (2017)

A 71-year-old woman underwent a posttherapy radioiodine scan after I administration for papillary thyroid carcinoma. On day 1 of the posttreatment hospital isolation, the patient received a Pneumovax injection in the left deltoid muscle. A localized hypersensitivity reaction ensued with development of soft tissue edema and erythema at the Pneumovax injection site. This localized reaction persisted up to the subsequent posttherapy radioiodine scan 5 days after injection. Increased activity at the left deltoid region suggests a false-positive finding related to radiotracer sequestration due to inflammation from a localized postvaccination hypersensitivity reaction.
The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells
Authors: Lifan Xu, Qizhao Huang, Haoqiang Wang, Yaxing Hao, Qiang Bai, Jianjun Hu, Yiding Li, Pengcheng Wang, Xiangyu Chen, Ran He, Bingshou Li, Xia Yang, Tingting Zhao, Yanyan Zhang, Yifei Wang, Juanjuan Ou, Houjie Liang, Yuzhang Wu, Xinyuan Zhou, Lilin Ye
Journal: Immunity (2017)
Household Air Pollution Is Associated with Altered Cardiac Function among Women in Kenya
Authors: Anubha Agarwal, Kipruto Kirwa, Melissa N. Eliot, Fawaz Alenezi, Diana Menya, Sumeet S. Mitter, Eric J. Velazquez, Rajesh Vedanthan, Gregory A. Wellenius, Gerald S. Bloomfield
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

available.Third, although the pathology was examined by two experienced thoracic pathologists, the slides were reviewed by both pathologists concurrently; therefore, we cannot provide data on interobserver variability.Finally, as only limited follow-up is available, we cannot comment on the clinical outcomes associated with ILA or specific histopathologic findings within this cohort.In conclusion, this study provides evidence that ILA-in particular, ILA with subpleural radiologic features-is most strongly associated with histopathologic findings of subpleural fibrosis as well as other histopathologic findings that are present in UIP.
FRI0698 Prevotella and alloprevotella species characterize the oral microbiome of early rheumatoid arthritis
Authors: B Wolff, S Boutin, H-M Lorenz, H Ueffing, A Dalpke, D Wolff
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> We previously showed that in this early rheumatoid arthritis (ERA) cohort with a mean disease duration of &lt;6 months, a clinically significant loss of clinical attachment loss as surrogate of alveolar bone loss is detectable compared with a matched healthy control cohort (1). Evidence is accumulating that distinct pathogens residing in reservoirs such as the oral cavity, the lung or the gut may play a role in driving the pathogenesis of RA (2–3). <h3>Objectives</h3> To characterize the oral microbiome associated with ERA. <h3>Methods</h3> 16S amplicon sequencing was used to analyze 88 samples of the supragingival and subgingival microbiome of 22 patients with ERA and 22 matched healthy controls. Oral and periodontal status, clinical activity of ERA and periodontitis, and socio-demographic parameters were used as explanatory variables in the next generation DNA sequencing analysis. <h3>Results</h3> Overall, a total of 4.702.161 16S RNA high-quality sequences were yielded. Using a distance-based similarity of &gt;97% for species-level operational taxonomic unit (OTU) assignment, a total of 1054 OTUs were identified (Fig 1). The oral microbiota was equally rich and diverse in ERA and control group. Subgingivally, <i>Prevotella oris, Prevotella oralis, Prevotella nigrescens, Alloprevotella rava</i> and <i>Alloprevotella tannerae</i> were associated with early RA independent of severity of periodontitis. <h3>Conclusions</h3> Prevotella and Alloprevotella species were enriched in patients with early RA independent of severity of periodontitis. Further studies are needed to test a causal relationship of these species with onset and/or disease progression of RA. <h3>References</h3> Oral status in patients with early rheumatoid arthritis: a prospective, case-control study. Wolff B, Berger T, Frese C, Max R, Blank N, Lorenz HM, Wolff D. Rheumatology (Oxford). 2014 Mar;53(3):526–31. The lung microbiota in early rheumatoid arthritis and autoimmunity. Scher JU, Joshua V, Artacho A, Abdollahi-Roodsaz S, Öckinger J, Kullberg S, Sköld M, Eklund A, Grunewald J, Clemente JC, Ubeda C, Segal LN, Catrina AI. Microbiome. 2016 Nov 17;4(1):60. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, Rostron T, Cerundolo V, Pamer EG, Abramson SB, Huttenhower C, Littman DR. Elife. 2013 Nov 5. <h3>Acknowledgements</h3> Wolff and Boutin contributed equally. <h3>Disclosure of Interest</h3> None declared
Michael Jackson’s Procedures
Authors: Michael Collins
Journal: JAMA (2017)

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PARE0001 Growing stronger together: implementing eular young pare's strategy
Authors: J Andersen, P Balazova, P Boyd, W Olsder, S Ostuzzi, T Papastavrou, SR Stones, T Wilhelmer, L Van Nieuwkoop, N Caeyers, F Klett
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Background</h3> In a recent European youth survey, 53% reported that rheumatic and musculoskeletal diseases (RMDs) affected their ability to work, while 75% reported that RMDs interrupted their education. Therefore, in 2017 and 2018, while continuing to achieve the objectives reached in 2015 and 2016, EULAR Young PARE will focus on two key points from EULAR Young PARE9s strategic objectives: work and education. <h3>Objectives</h3> In 2017, in line with EULAR9s efforts to raise awareness of the needs of people with RMDs among employers and other stakeholders, the specific and still unmet needs of young people with RMDs will be highlighted, so that employers and other stakeholders will be more aware of the needs of young people with RMDs and young people will receive better support to find a suitable job. In 2018, education for young people with RMDs will be in focus, so that educational institutions across Europe will be more flexible and assistive in supporting high quality education for young people with RMDs. <h3>Methods</h3> In 2017, we will support EULAR9s lobbying activities by raising awareness among employers and other stakeholders about the needs of young people with RMDs. We will also provide information to support young people in finding suitable jobs and to be aware of their rights in the workplace. Best practices concerning ergonomics, support programmes, career counselling and suitable jobs will be collected and shared. In 2018, we will support educational institutions across Europe to be more flexible and assistive in providing high quality education for young people with RMDs by offering training and support to national youth leaders. <h3>Results</h3> Thanks to the results achieved in 2015 and 2016, it is anticipated that structures will be in place to continuously raise awareness among employers, medical staff in schools, teachers and unions about the competencies and limitations of young people with RMDs. These activities enable EULAR Young PARE to expand and strengthen the active network of youth groups across Europe. Every PARE organisation will have a PARE youth liaison person, who will be encouraged and supported to take active roles in their national organisations and in the EULAR community. <h3>Conclusions</h3> The objectives reached by EULAR Young PARE in 2015 and 2016 are closely related to its future aims and achievements, allowing EULAR Young PARE to grow stronger and continue its work by the side of young people with RMDs, in order to improve their quality of life. <h3>References</h3> EULAR Young PARE. Available from: http://www.youngpare.org[accessed on 30 January 2017]. <h3>Acknowledgements</h3> Special thanks to EULAR and EULAR PARE for supporting the vision of EULAR Young PARE. EULAR Young PARE would also like to acknowledge all of the patient organisations that they continue to work with. <h3>Disclosure of Interest</h3> None declared