tbuckley/cabot-search huggingface dataset:
Abstract 163: Interleukin-13 Expression Attenuates Left Ventricular Dilation and Mortality After Myocardial Infarction
Authors: Ulrich Hofmann, Susanne Knorr, Johannes Weirather, Anna Frey, Stefan Frantz
Journal: Circulation Research (2012)

Background: Monocyte infiltration and extracellular matrix breakdown/ de novo formation critically influence wound healing and remodeling after myocardial infarction (MI). Interleukin-13 (IL-13) has potent pro-fibrotic properties and is a differentiation factor for monocytes/ macrophages. Therefore, we studied whether IL-13 affects myocardial wound healing and remodelling after MI. Methods and results: MI was induced by permanent ligation of the left coronary artery in WT and IL-13-/- mice. Expression of IL-13 was upregulated in the myocardium after MI. IL-13 expression was in part dependent on angiotensin II signalling as in vivo treatment with the Angiotensin-receptor blocker losartan attenuated myocardial IL-13 expression in response to MI. Intracellular FACS analysis of myocardial leukocytes further demonstrated IL-13 expression in a subset of myeloid CD11b+ cells within the myocardium. IL-13-/- mice showed higher mortality than WT mice after MI without difference in infarct size. Echocardiography further demonstrated increased left ventricular dilation in IL-13-/- when compared to WT mice. Histological analysis of the scar collagen did not reveal a difference between WT and IL-13-/- mice. FACS analysis of leukocytes from the infarct zone showed less MHC-II+ CD11b+ cells within the myocardium of IL-13-/- mice on day 7 indicating that IL-13 is required for the differentiation of heart infiltrating monocytes. Conclusions: Expression of IL-13 in response to MI beneficially modulates wound healing after MI.
AB0169 Fibromyalgia. geriatrics problem?
Authors: A Laiz, H Corominas, M Peiró, S Fernández, C Díaz, G Vázquez
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To study in a group of patients, of a rheumatoloy unit in primary care the presence of fibromyalgia and tocompare the results between those with more and less than 65 years. <h3>Methods</h3> From a rheumatoloy unit in primary care, in Barcelona, during one year, we selected the patients with fibromyalgia. The diagnostic was done according with ACR criteria 1990. Stadistical method used for comparisions was the chi- square test and correction of continuidad. <h3>Results</h3> Visits performed were 1555. The mean was 61 ± 15 (Table 1). Between them (p &lt; 0.05). <h3>Conclusion</h3> The prevalence of fibromyalgia is similar to others studies. Fibromyalgia in people with more than 65 years, is in our group very low. This result can be real or because from the primary care this pathology in this group of people is not considered so important as others.
Genetic Predisposition to Abdominal Adiposity and Cardiometabolic Risk
Authors: Matthias B. Schulze, Norbert Stefan
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Raman-Encoded Molecular Imaging with Topically Applied SERS Nanoparticles for Intraoperative Guidance of Lumpectomy
Authors: Yu “Winston” Wang, Nicholas P. Reder, Soyoung Kang, Adam K. Glaser, Qian Yang, Matthew A. Wall, Sara H. Javid, Suzanne M. Dintzis, Jonathan T.C. Liu
Journal: Cancer Research (2017)

Abstract Intraoperative identification of carcinoma at lumpectomy margins would enable reduced re-excision rates, which are currently as high as 20% to 50%. Although imaging of disease-associated biomarkers can identify malignancies with high specificity, multiplexed imaging of such biomarkers is necessary to detect molecularly heterogeneous carcinomas with high sensitivity. We have developed a Raman-encoded molecular imaging (REMI) technique in which targeted nanoparticles are topically applied on excised tissues to enable rapid visualization of a multiplexed panel of cell surface biomarkers at surgical margin surfaces. A first-ever clinical study was performed in which 57 fresh specimens were imaged with REMI to simultaneously quantify the expression of four biomarkers HER2, ER, EGFR, and CD44. Combined detection of these biomarkers enabled REMI to achieve 89.3% sensitivity and 92.1% specificity for the detection of breast carcinoma. These results highlight the sensitivity and specificity of REMI to detect biomarkers in freshly resected tissue, which has the potential to reduce the rate of re-excision procedures in cancer patients. Cancer Res; 77(16); 4506–16. ©2017 AACR.
Randomized, open-label phase Ib/II study of atezolizumab with or without daratumumab in previously treated advanced or metastatic non-small cell lung cancer (NSCLC).
Authors: Rathi Narayana Pillai, Suresh S. Ramalingam, David P. Carbone, Luis G. Paz-Ares, Meena Thayu, Patricia Watson, Nushmia Z. Khokhar, Martin Reck
Journal: Journal of Clinical Oncology (2017)

TPS9102 Background: Daratumumab (DARA), a human CD38 monoclonal antibody, is approved for treatment of relapsed/refractory multiple myeloma (RRMM). DARA produces deep clinical responses in RRMM and induces T-cell expansion through reduction of immune suppressive cell populations (CD38 + myeloid-derived suppressor cells and regulatory T and B cells). Atezolizumab (atezo) blocks programmed death-ligand 1 (PD-L1) and was recently approved for metastatic NSCLC that progressed on or during platinum therapy based on data showing improved overall survival (OS) in the atezo vs docetaxel treatment arm. A combination of DARA and atezo may improve clinical responses in NSCLC by enhancing anti-tumor T-cell responses facilitated by checkpoint inhibition. This study will assess the anti-tumor activity and safety profile of DARA plus atezo vs atezo alone in patients (pts) with previously treated advanced or metastatic NSCLC. Methods: This is an ongoing phase 1b/2 randomized, open-label, multicenter study of atezo (1200 mg intravenous [IV]; Day 2 of Cycle 1 and Day 1 of each 21-day cycle thereafter) alone or in combination with DARA (16 mg/kg IV weekly for 3 cycles [Days 1, 8, and 15] and then Day 1 of each 21-day cycle thereafter). Eligible pts (≥18 years) must have advanced or metastatic NSCLC and received standard platinum-based therapy with disease progression or intolerance to therapy. ECOG performance status of ≤1 and known PD-L1 tumor status are required. Pts previously treated with anti-CD38 therapy, including DARA, CD137 agonists, or immune checkpoint inhibitors are excluded. The primary endpoint is overall response rate. Secondary outcomes include safety, duration of response, clinical benefit rate (≥16 weeks duration), progression-free survival, OS, and pharmacokinetics and immunogenicity of DARA and atezo when given in combination. Approximately 96 pts will be enrolled; 6 pts will receive combination therapy in a safety run-in cohort for evaluation of dose-limiting toxicity followed by 90 pts randomly (1:1) assigned to the 2 treatments. Clinical trial information: NCT03023423.
Engrailed protein: A cancer-specific marker in epithelial ovarian cancer.
Authors: Sophie McGrath, Nicola E. Annels, Thumuluru Kavitha Madhuri, Ben Haagsma, Emmanuel Douglas Larbi, Hardev S. Pandha, Agnieszka Michael
Journal: Journal of Clinical Oncology (2012)

e15517 Background: Ovarian cancer is a common malignancy, accounting for 4% of all cancers and 5% of all cancer deaths in women in the Western world. Engrailed-2 (EN2) is a homeodomain–containing transcription factor that is essential during early development. It is dysregulated in a number of cancers and its presence in urine is diagnostic of prostate cancer. We have investigated its role as a cancer-specific marker in epithelial ovarian cancer (EOC). Methods: Ovarian tumours and normal tissue were collected from patients with epithelial ovarian cancer (EOC) and tested by semi-quantitative RT-PCR as well as by immunohistochemistry. EN2 expression relative to B-actin was calculated using the Livak comparative Ct method (2 -DDCt ). All slides were scored on a 0-3 scale based on intensity, by two independent assessors. Results: We examined 118 EOC specimens, of which 64 were tested by immunohistochemistry and 54 by RT-PCR. 89 (75.42%) were serous, 18 (15.25%) endometroid, 7 (5.93%) mucinous, and 4 (3.39%) clear cell tumours. Normal ovarian tissue was used as a control. 104 (88.14%) tumours expressed EN2 whilst 14 (11.86%) were negative. Of the EN2 positive tumours examined using immunohistochemistry, 28 (51.85%) strongly expressed the antigen (score of 2-3), whereas 26 (48.15%) were weakly positive (score of 1). Normal tissue did not express EN2 and this difference was statistically significant (p&lt;0.05). There was no correlation with tumour type, grade and stage. EN2 expressing mucinous tumours showed improved overall survival (p=0.0253). There was no correlation for survival or PFS for other histological subtypes. Conclusions: EN2 is a cancer-specific marker in epithelial ovarian cancer. Further work is currently ongoing to evaluate its significance in ascites, blood and urine. We plan to further evaluate its role as a diagnostic biomarker by examining blood, urine, and ascites.
Introduction of Macrophage Tolerance By Human SIRPA Knock-in Enhances Peripheral Reconstitution of Human Hematopoiesis in Xenotransplantation Model
Authors: Fumiaki Jinnouchi, Katsuto Takenaka, Chika Iwamoto, Takuji Yamauchi, Ayano Yurino, Takuya Nunomura, Yoshikane Kikushige, Koji Kato, Toshihiro Miyamoto, Koichi Akashi
Journal: Blood (2016)
Evidence of T-Cell Oligoclonality in a Retrospective Series of Enteropathy-Associated T-Cell Lymphomas (EATLS) and Ulcerative Jujunitis Using RNA Extracted from Formalin-Fixed Paraffin-Embedded Tissue
Authors: U O'Shea, JI Wyatt, P Howdle
Journal: Endoscopy (2004)

Aims: To analyse the T-cell receptor Vβ (TCR Vβ) repertoire in a series of formalin- fixed paraffin embedded tissue blocks from patients diagnosed with enteropathy associated T-cell lymphoma (EATL) or with ulcerative jejunitis (UJ), by reverse transcription polymerase chain reaction (RT-PCR) and by complementarity determining region 3 (CDR3) spectratyping.
First-Line Dasatinib Plus Conventional Chemotherapy in Adults with Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL): Interim Analysis of the Korean Prospective Phase II Study
Authors: Seok Lee, Dong-Wook Kim, Yoo-Jin Kim, Ho-Young Yhim, Jae-Yong Kwak, Deok-Hwan Yang, Je-Jung Lee, Soo-Jeong Kim, Jin-Seok Kim, Seh Jong Park, Chul Won Choi, Jong-Wook Lee, Woo-Sung Min, Chong-Won Park
Journal: Blood (2011)
Abstract P164: N-acetylglucosamine Conjugated to Nanoparticles Enhances Myocyte Uptake and Improves Delivery of a Small Molecule P38 Inhibitor for Postinfarct Healing
Authors: Warren D Gray, Pao Lin Che, Milton Brown, Xinghai Ning, Niren Murthy, Michael E Davis
Journal: Circulation Research (2011)

An estimated 985,000 new myocardial infarctions (MI) will occur in the U.S. in 2011. While many will survive the initial insult, the early damage will eventually lead to heart failure for which the only definitive cure is transplantation. Cardiomyocyte (CM) apoptosis is a large contributor to cardiac dysfunction, and although potential therapeutic molecules exist to inhibit apoptotic pathways, drug delivery methods are lacking. This damage is largely regional and thus localized delivery of therapeutics holds great potential. However, CMs are relatively non-phagocytic, which precludes existing delivery schemes using polymeric particles that target phagocytic cells. Recently, the carbohydrate N-acetyl-glucosamine (GlcNAc) was discovered to be bound and internalized by CMs, providing a potential mechanism for drug delivery. Here we demonstrate efficacy of a drug delivery system comprising a drug-loaded biodegradable polyketal nanoparticle that is surface-decorated with GlcNAc. Inclusion of the sugar enhanced uptake by CMs in vitro as measured by intracellular activated fluorescence. When delivered in vivo following ischemia-reperfusion injury, GlcNAc-decorated particles loaded with the p38 inhibitor SB239063 reduced infarct size and improved acute cardiac function. This was in contrast to our published data demonstrating no acute effect of non-sugar decorated, p38 inhibitor-loaded particles. These data suggest a novel therapeutic option to enhance uptake of drug-loaded nanoparticles to CMs, and perhaps to reduce the large amount of CM cell death following myocardial injury.
Submucosal tunneling endoscopic resection of a gastric gastrointestinal stromal tumor
Authors: Francesco Azzolini, Paolo Cecinato, Elisabetta Froio, Romano Sassatelli
Journal: Endoscopy (2017)

A 64-year-old man was admitted to our hospital for endoscopic resection of a gastrointestinal stromal tumor (GIST) of the gastric antrum.
Hybrid Magnetic Resonance Imaging and Positron Emission Tomography With Fluorodeoxyglucose to Diagnose Active Cardiac Sarcoidosis
Authors: Marc R. Dweck, Ronan Abgral, Maria Giovanna Trivieri, Philip M. Robson, Nicolas Karakatsanis, Venkatesh Mani, Anna Palmisano, Marc A. Miller, Anuradha Lala, Helena L. Chang, Javier Sanz, Johanna Contreras, Jagat Narula, Valentin Fuster, Maria Padilla, Zahi A. Fayad, Jason C. Kovacic
Journal: JACC. Cardiovascular imaging (2017)
Early Response–Based Therapy Stratification Improves Survival in Adult Early Thymic Precursor Acute Lymphoblastic Leukemia: A Group for Research on Adult Acute Lymphoblastic Leukemia Study
Authors: Jonathan Bond, Carlos Graux, Ludovic Lhermitte, Diane Lara, Thomas Cluzeau, Thibaut Leguay, Agata Cieslak, Amélie Trinquand, Cedric Pastoret, Mohamed Belhocine, Salvatore Spicuglia, Véronique Lheritier, Stéphane Leprêtre, Xavier Thomas, Françoise Huguet, Norbert Ifrah, Hervé Dombret, Elizabeth Macintyre, Nicolas Boissel, Vahid Asnafi
Journal: Journal of Clinical Oncology (2017)

Purpose Early thymic precursor (ETP) acute lymphoblastic leukemia (ALL) is an immunophenotypically defined subgroup of T-cell ALL (T-ALL) associated with high rates of intrinsic treatment resistance. Studies in children have shown that the negative prognostic impact of chemotherapy resistance is abrogated by the implementation of early response–based intensification strategies. Comparable data in adults are lacking. Patients and Methods We performed comprehensive clinicobiologic, genetic, and survival analyses of a large cohort of 213 adult patients with T-ALL, including 47 patients with ETP-ALL, treated in the GRAALL (Group for Research on Adult Acute Lymphoblastic Leukemia) -2003 and -2005 studies. Results Targeted next-generation sequencing revealed that the genotype of immunophenotypically defined adult T-ALL is similar to the pediatric equivalent, with high rates of mutations in factors involved in cytokine receptor and RAS signaling (62.2%), hematopoietic development (29.7%), and chemical modification of histones (48.6%). In contrast to pediatric cases, mutations in DNA methylation factor genes were also common (32.4%). We found that despite expected high levels of early bone marrow chemotherapy resistance (87%), the overall prognosis for adults with ETP-ALL treated using the GRAALL protocols was not inferior to that of the non–ETP-ALL group (5-year overall survival: ETP, 59.6%; 95% CI, 44.2% to 72.0% v non-ETP, 66.5%; 95% CI, 58.7% to 73.2%; P = 0.33) and that allogeneic stem-cell transplantation had a beneficial effect in a large proportion of patients with ETP-ALL. Conclusion Our results suggest that the use of response-based risk stratification and therapy intensification abrogates the poor prognosis of adult ETP-ALL.
Abstract O.13: Kawasaki disease in the Maghreb community in Quebec
Authors: Arbia A Gorrab, Asma Abed Bouaziz, Linda Spigelblatt, Anne Fournier, Nagib Dahdah
Journal: Circulation (2015)

Background: The real incidence of Kawasaki disease (KD) in the Maghreb countries (Morocco, Algeria, and Tunisia) is unknown. It is estimated low according to the literature. However, the number of Maghrebi children living in Quebec (Qc) affected by KD seems important. We sought to determine the incidence of KD among Maghrebi children in Qc, Canada, and to study its epidemiological and clinical features and to clarify possible risk factors related or superimposed to their immigration. Methods: A retrospective study of KD in Maghrebi children living in Qc (n=24) (1996-2013), compared to reports from Fes, Morocco (n=23) a doctoral thesis published in 2010 (2001-2009) and from Tunisia (n=31) collected in five university hospitals with four from the Great Tunis and one from Nabeul city (1996-2013). There are no reports available from Algeria. The “country of origin” specific population in the Province of Qc was obtained from Statistics Canada. Results: The annualized incidence rate (AIR) of KD among Maghrebi children in Qc was 9.58/100,000 children under 5 years(Standard-Denominator (SD)).This is 6 times higher in Qc (5.57/SD and 19.02/SD among Tunisian and Moroccan descents) vs Tunisia (Nabeul Governorate) and Morocco (Fes) (0.95/SD and 3.15/SD). Personal and family history of allergy were significantly higher in Qc 42% (10/24) and 75% (18/24), respectively, whereas these features were reported near 0% in both reports from Morocco and Tunisia. The prevalence of incomplete KD criteria was relatively high in the 3 series 46% (11/24) in Qc vs 43% (10/23) and 35% (11/31); (p=NS). Diagnosis was late (gt day 10 of fever) in 1/24(4%) in Qc vs 7/23 (30%) in Morocco and 11/31 (35%) in Tunisia; (p 0.01). IVIG were administered in the acute phase to all patients in Qc, 5/23 in Morocco and 28/31 in Tunisia. However coronary complications were more common in Qc 42% (10/24) vs 22% (5/23) vs 19% (6/31) (p=0.02). Aneurysms were significantly associated with the incomplete form in the 3 groups (p=0.01). Conclusions: The observed AIR of KD in the Maghreb community in Qc is higher than the countries of origin where underdiagnosis is possible. Atopy may still be a risk factor in Qc. The coronary artery disease seems linked not only to therapeutic delay but also to the underlying terrain.
64 Magnetic resonance of the small bowel with early (70s) and late (7MINS) phase post gadolinium imaging to identify fibrosis in stricturing small bowel crohn’s disease
Authors: R Stack, C O’Brien, T Nuzum, S Cummins, M Hussey, N O’Morain, A O’Connor, N Breslin, B Ryan, I Murphy, D McNamara
Journal: Gut (2017)

Background  Strictures are a serious complication of Ileal Crohn’s disease (CD). Current assessment tools poorly differentiate fibrotic from inflammatory lesions and do not predict response. The magnetic resonance index of activity (MaRIA) is a validated means to assess activity. Its ability to characterise fibrosis remains unclear. Recent evidence suggests relative contrast enhancement (REC) of >24% on delayed MRI sequences may accurately detect fibrosis.  Aim  Compare MaRIA, RCE and biochemical activity in patients with Ileal CD.  Method  Prospective study of patients undergoing MRE for known CD. MRE was performed as standard with additional coronal T1 sequences 7 min post gadolinium administration. Two independent blinded Radiologists calculated RCE and MaRIA’s at 70 s and 7 min. Demographics and CRP were recorded.  Results  26/29 MRE’s performed had ileal CD, median age=41 years, male=10 (38%). RCE >24% and high T2 signal intensity (SI); 6/26 (23%) and 11/26 (42.3%). REC >24% occurred in only 1/10 with a visible stenosis. Average MaRIA’s: 2/26 (7.7%) 11 severe. MaRIA’s did not change significantly between 70 s and 7 min. As expected T2 SI increased with MaRIA’s>11, 26 v 13 (p 11 (13.3 vs 5.2) and lower in patients with RCE >24% (3.9 vs 14), p  Conclusions  RCE may be a useful adjunct to current MRE and help detect fibrosis in small bowel lesions and warrants further investigation.
Patch testing in patients with psoriasis: results of a 30-year retrospective study
Authors: W. Alwan, M. Lynch, J. McFadden, I.R. White, P. Banerjee
Journal: British Journal of Dermatology (2017)

Psoriasis and allergic contact dermatitis (ACD) are common, chronic T-lymphocyte mediated conditions. Although psoriasis patients are commonly referred for patch testing, there are conflicting views on the relationship between contact allergy and psoriasis. Previous studies have suggested ACD is less common in psoriasis1 and that psoriatics are more difficult to sensitize1,2,3.

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Assessment of Patients Referred for Percutaneous Endoscopic Gastrostomy is Beneficial
Authors: S Woods, CM Smyth, SE Patchett, FE Murray
Journal: Endoscopy (2004)

Introduction: The insertion of percutaneous endoscopic gastrostomy (PEG) feeding tubes has become the procedure of choice for long-term enteral feeding. Gastroenterologists are increasingly requested to insert PEG tubes, some of which may be inappropriate or unnecessary.
Characterization of Real World Survival Outcomes Among Older Adults with Chronic Lymphocytic Leukemia Receiving Second Line Treatment in the Pre Novel-Agents Era: An Analysis of the 2007-2013 SEER-Medicare Database
Authors: Anthony R. Mato, Jordan Jahnke, Pengxiang Li, Maneesha Mehra, Vrushabh P Ladage, Michelle Mahler, Molly Fanning, Jalpa A Doshi, Scott F Huntington
Journal: Blood (2016)