Abstract 3275: The impact of tumor locations on survival of the patients with esophageal squamous cell carcinoma
Authors: Yan Jin, Yan Jin, Fu You Zhou, Ran Wang, Zhi Qiang Li, Zhi Cai Liu, Dao Cun Wang, Yin Li, Ping Lu, Peng Yuan Zheng, Chang Wei Feng, Guo Qiang Kong, Shao Hua Han, Li Dong Wang
Journal: Cancer Research (2017)

Abstract In contrast to western population with majority of adenocarcinoma at lower third segment, esophageal cancer in China occurs predominantly in the middle third segment of the esophagus and squamous cell carcinoma (ESCC) remains the major histopathological type. The mechanism for the dramatic difference in terms of tumor location and histological type is not clear. Obviously, the different tumor locations will have impact on optimal choice of treatment, and may have different lymph drainage which will then influence the lymph node metastasis. The present study was thus undertaken to characterize the impact of different tumor locations (cervical, the upper, middle, lower thoracic portion) on survival of the ESCC patients from Henan in Northern China. All the patients in this study were from the ESCC database in Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University. Of the 62,311 ESCC patients enrolled in this study, there were 37,263 males (59.8%) with a mean age of 59.61±9.62 and 25070 females (40.23%) with a mean age of 60.45±9.68. The ratio of male to female was 1.49:1 (P &amp;lt; 0.01). These patients were classified into four groups with different periods based on diagnosed time, group I (1975 to 1984, 6.51%), group II (1985 to 1994, 21.91%), group III (1995 to 2004, 30.98%) and group IV (2005 to 2016, 40.59%). Based on the 6th version of UICC criteria, the tumor locations were recorded as cervical, upon, middle and lower third segments. The followed–up was undertaken until 2016. The SPSS21.0 software and Kaplan–Meier survival analysis and Log Rank test were used to evaluate the survival of different locations. The results demonstrated that the most common location for ESCC was in the middle third segment (64.5%), followed by upon third segment (19.00%), lower third segment (15.10%) and cervical segment (1.40%) (P&amp;lt;0.001). Log Rank test showed that the ESCC at lower segment had the best survival, followed by middle and upon segments. The cervical segment had worsen survival (P&amp;lt;0.01). The present results indicate that the tumor location has obvious impact on ESCC survival, further studies need to elucidate the mechanism. [Supported by Doctoral Team Foundation of the First Affiliated Hospital of Zhengzhou University (2016–BSTDJJ–03), Natural Science Foundation of Henan Province (20161110) and Correspondence to: Li Dong Wang, Email: ldwang2007@126.com]. Note: This abstract was not presented at the meeting. Citation Format: Yan Jin, Yan Jin, Fu You Zhou, Ran Wang, Zhi Qiang Li, Zhi Cai Liu, Dao Cun Wang, Yin Li, Ping Lu, Peng Yuan Zheng, Chang Wei Feng, Guo Qiang Kong, Shao Hua Han, Li Dong Wang. The impact of tumor locations on survival of the patients with esophageal squamous cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3275. doi:10.1158/1538-7445.AM2017-3275