tbuckley/cabot-search huggingface dataset:
P047 Anti-collagen type ii antibodies are associated with early inflammation in malaysian rheumatoid arthritis patients with three different ethinicities
Authors: CL Too, VA Manivel, E Persinidou, J Rönnelid, S Murad
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Objectives</h3> We have previously shown that Caucasian rheumatoid arthritis (RA) patients with anti-collagen type II antibodies (anti-CII) have an acute onset phenotype with elevated levels of C-reactive protein (CRP) and erythrocyte sedimentation rate, as well as higher disease activity score and number of swollen joints [Manivel <i>et al. Ann Rheum Dis</i> 2017 September;76(9):1529–1536]. Our aim was to replicate this in a multiethnic Malaysian RA cohort. <h3>Methods</h3> Anti-CII, anti-CCP2, IgM RF and IgG RF were measured in 1,105 Malaysian early RA patients and 1565 healthy controls of Malay, Chinese or Indian ethnicity in the Malaysian Epidemiological Investigation of RA (MyEIRA) case control study, and related to baseline CRP and to HLA-DRB1* alleles. <h3>Results</h3> 106/1,105 (9.6%) of the RA patients had elevated anti-CII. Anti-CII levels were higher in RA patients than in controls (p&lt;0.0001), generally higher in Malay than in Indian or Chinese subjects, and also higher in Malaysian than in Swedish healthy controls. All measured autoantibodies associated with elevated baseline CRP. The occurrence of anti-CII did not associate with the occurrence of anti-CCP2, IgG RF and IgM RF, and when patients with only one antibody were compared to antibody negative patients, only anti-CII associated with elevated CRP (p=0.0310). HLA-DRB1*12:01 positive patients has higher levels of anti-CII (p=0.01) whereas Malaysian Malay patients with HLADRB1*12:02 had lower anti-CII levels (p&lt;0.002) as compared to individuals lacking the corresponding genotype. <h3>Conclusions</h3> Elevated anti-CII levels at the time of RA onset associate with an early inflammatory RA phenotype not only in Caucasian, but also in an Asian RA population. This supports our hypothesis that the association between early elevations of anti-CII and the acute onset RA phenotype is a finding of global validity. <h3>Reference</h3> . Manivel VA, Mullazehi M, Padyukov L, et al. Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up. Annals of the Rheumatic Diseases2017;76(9):1529–1536. doi:10.1136/annrheumdis-2016-210873 <h3>Acknowledgements</h3> The MyEIRA study group- Chiara Berretta, Heselynn Hussein, Wahinuddin Sulaiman, Ing Soo Lau, Suk Chyn Gun, Nor Suhaila Sharil, M. Eashwary, Mohamed Said Mohd-Shahrir, Ainon Mohd Mokhtar, Azmillah Rosman, Muhaini Othman, Lars Alfredson and Lars Klareskog. <h3>Disclosure of interest</h3> None declared
HYPERURICEMIA IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION AND MORPHOLOGICAL ABNORMALITIES OF NEOINTIMA AFTER 2ND GENERATION DRUG-ELUTING STENTS DEPLOYMENT ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY
Authors: Satoshi Yoshino, Hiroyuki Tabata, Masaaki Miyata, Daisuke Kanda, Kenta Ohmure, Yoshihiro Uchikado, Mitsuru Ohishi
Journal: Journal of the American College of Cardiology (2018)
Validation of the 8<sup>th</sup> AJCC TNM staging system for gastric cancer: Survival analysis with high volume Asian centers and SEER database by comparing with 7<sup>th</sup> TNM staging system.
Authors: Taeil Son, Jiyu Sun, Hyoung-Il Kim, Jae-Ho Cheong, Seung Ho Choi, Sung Hoon Noh, Yanghee Woo, Yuman Fong, Sohee Park, Woo Jin Hyung
Journal: Journal of Clinical Oncology (2018)

18 Background: Recently, the 8th AJCC TNM staging system for estimating prognosis for patients with gastric cancer was revised with new subgroups. There are little number of studies have shown its validation with other datasets. We aimed to validate the new TNM staging system by using various datasets with large number of gastrectomies. Methods: We retrospectively reviewed data of 17160, 11324 and 1500 patients treated for gastric cancer in Yonsei University Severance Hospital (SH), The Surveillance, Epidemiology, and End Results (SEER) and Gangnam Severance Hospital (GSH), respectively. Survival curves were plotted and the performance of tumor staging defined by the 7 th and 8 th TNM staging was compared based on the log-rank test, Concordance index (C-index) and Akaike information criterion (AIC). Results: The performance of predicting survival using the 8 th TNM staging system is superior to that of the previous version in SH by evaluating log-rank, C-statistics, and AIC (8444.5 vs. 9263.8, 0.796 vs. 0.798, 104152 vs. 103909), respectively. It is also superior in a data with SEER and GSH (log-rank, C-statistics, and AIC; 3342 vs. 3527, 0.7064 vs. 0.709, 100931 vs. 100820 in SEER, 973 vs. 1031, 0.8021 vs. 0.8038, 7173 vs. 7154 in GSH), respectively. In subgroup analysis of each subclassification, IA, IB, IIA, IIB, IIIA, IIIB, IIIC, and IV in SH, the 8 th TNM staging system shows similar or more homogenous survival (0.0324 vs. &lt; 0.001 in Stage IIB, 0.020 vs. &lt; 0.0001 in Stage IIIB, 0.0004 vs. &lt; 0.0001 in Stage IIIC, respectively) in each subclassification than that of the 7 th TNM staging system by measuring log-rank p values. Conclusions: The 8th TNM staging system provides more accurate prediction of prognosis of gastric cancer patients than the previous one. In addition, each subgroup in the same stage is relatively homogenous with respect to survival than the previous staging system. It is also applicable to Eastern and Western patients with various backgrounds.
IS DISEASE ACTIVITY OF CARDIAC SARCOIDOSIS SUPPRESSED DURING MAINTENANCE DOSE PERIOD OF CORTICOSTEROID THERAPY? EVALUATION BY FDG-PET
Authors: Jihaeng Im, Naoki Serizawa, Kenji Fukushima, Yasutaka Imamura, Arata Nomura, Akiko Sakai, Mitsuru Momose, Michinobu Nagao, Tsuyoshi Shiga, Koichiro Abe, Nobuhisa Hagiwara
Journal: Journal of the American College of Cardiology (2018)
Master of Science (MSc) in Neuroscience at the Institute of Psychiatry, King's College London
Authors: Peter Aquino
Journal: BMJ (2007)

Light micrograph of nerve cells (neurons) with immunofluorescent staining. 

Credit: FRANCOIS PAQUET-DURAND/SPL



FURTHER INFORMATION 

Programme administrator, MSc in Neuroscience, MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF. http://neuroscience.iop.kcl.ac.uk/msc/

This is a one year full time or two year part time masters degree which aims to provide specialist postgraduate training in neuroscience and covers a wide …
Reported Biologic Differences in Breast Cancer by Race Due to Disparities in Screening—Reply
Authors: Dezheng Huo, Charles M. Perou, Olufunmilayo I. Olopade
Journal: JAMA Oncology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
ROLE OF METABOLIC MANIPULATOR TRIMETAZIDINE IN LIMITING PERCUTANEOUS CORONARY INTERVENTION ASSOCIATED MYOCARDIAL INJURY
Authors: Paurush Ambesh, Danish H. Kazmi, Aditya Kapoor, Archana Sinha, Roopali Khanna, Sudeep Kumar, Naveen Garg, Satyendra Tewari, Pravin Goel
Journal: Journal of the American College of Cardiology (2018)
Tumor platinum concentrations and pathological responses following preoperative cisplatin-containing chemotherapy in gastric or gastroesophageal junction cancer patients.
Authors: Yanshuo Cao, Qing Chang, Michael Cabanero, Wenjiang Zhang, Sara Hafezi-Bakhtiari, David W. Hedley, Gail Elizabeth Darling, Fayez A. Quereshy, Raymond Woo-Jun Jang, Elena Elimova, Jennifer J. Knox, Olga Ornatsky, Stefano Serra, Eric Xueyu Chen
Journal: Journal of Clinical Oncology (2018)

76 Background: Perioperative chemotherapy plus surgical resection is a standard of care for locally advanced gastric or gastroesophageal junction (GEJ) cancers. There is a wide range in tumor response following cisplatin-containing preoperative chemotherapy. We investigated the relationship between tumor platinum levels and pathological tumor responses in gastric or GEJ cancer patients following preoperative chemotherapy. Methods: Tumor and adjacent normal tissues were retrieved. Pathological responses were assessed per standard criteria. Tissue platinum concentrations were determined with high-performance liquid chromatography mass spectrometry. Platinum distribution in tissue components was evaluated with imaging mass cytometry. Tissue collagen content was evaluated using trichrome staining. Results: Ten patients were enrolled in this study. Nine patients received 3 cycles of preoperative chemotherapy and 1 received 2 cycles. The median cumulative cisplatin dose was 166.8 mg/m 2 (range: 95.9–181.1 mg/m 2 ). Surgery was performed at a median time of 49 days (range: 28–72 days) after the last cycle of chemotherapy. The mean platinum level in tumor tissue in patients with any response was 893 ± 460 pg, significantly higher than in those with no response [38.8 ± 8.8 pg (p = 0.007)]. The collagen content was significantly higher in patients with any response than in those with no response (37.4 ± 6.8% vs. 11.5 ± 8.6%, p &lt; 0.05). Platinum preferentially bound to collagen. Conclusions: Platinum was detectable in surgical specimens up to 72 days after preoperative chemotherapy. Higher tumor platinum concentration correlated with improved pathological response. Collagen binding potentially explained the high interpatient variability in tumor platinum concentrations.
T-type Ca2+ Channels: T for Targetable
Authors: Marta C. Sallán, Anna Visa, Soni Shaikh, Mireia Nàger, Judit Herreros, Carles Cantí
Journal: Cancer Research (2018)

Abstract In the past decade, T-type Ca2+ channels (TTCC) have been unveiled as key regulators of cancer cell biology and thus have been proposed as chemotherapeutic targets. Indeed, in vitro and in vivo studies indicate that TTCC pharmacologic blockers have a negative impact on the viability of cancer cells and reduce tumor size, respectively. Consequently mibefradil, a TTCC blocker approved in 1997 as an antihypertensive agent but withdrawn in 1998 because of drug–drug interactions, was granted 10 years later the orphan drug status by the FDA to investigate its efficacy against brain, ovary, and pancreatic cancer. However, the existence of different channel isoforms with distinct physiologic roles, together with the lack of selective pharmacologic agents, has hindered a conclusive chemotherapeutic evaluation. Here, we review the available evidence on TTCC expression, value as prognostic markers, and effectiveness of their pharmacologic blockade on cancer cells in vitro and in preclinical models. We additionally summarize the status of clinical trials using mibefradil against glioblastoma multiforme. Finally, we discuss the future perspectives and the importance of further development of multidisciplinary research efforts on the consideration of TTCCs as biomarkers or targetable molecules in cancer. Cancer Res; 78(3); 603–9. ©2018 AACR.
Non ABL-directed inhibitors as alternative treatment strategies for chronic myeloid leukemia
Authors: Michele Massimino, Stefania Stella, Elena Tirrò, Chiara Romano, Maria Stella Pennisi, Adriana Puma, Livia Manzella, Antonino Zanghì, Fabio Stagno, Francesco Di Raimondo, Paolo Vigneri
Journal: Molecular Cancer (2018)

The introduction of ABL Tyrosine Kinase Inhibitors (TKIs) has significantly improved the outcome of Chronic Myeloid Leukemia (CML) patients that, in large part, achieve satisfactory hematological, cytogenetic and molecular remissions. However, approximately 15–20% fail to obtain optimal responses according to the current European Leukemia Network recommendation because of drug intolerance or resistance. Moreover, a plethora of evidence suggests that Leukemic Stem Cells (LSCs) show BCR-ABL1-independent survival. Hence, they are unresponsive to TKIs, leading to disease relapse if pharmacological treatment is discontinued. All together, these biological events generate a subpopulation of CML patients in need of alternative therapeutic strategies to overcome TKI resistance or to eradicate LSCs in order to allow cure of the disease. In this review we update the role of "non ABL-directed inhibitors" targeting signaling pathways downstream of the BCR-ABL1 oncoprotein and describe immunological approaches activating specific T cell responses against CML cells.
How to improve your time management skills
Authors: Sarah Christie, Matt Green
Journal: BMJ (2012)

<b>Sarah Christie</b>, author of <i>Effective Time Management Skills for Doctors</i>, and <b>Matt Green</b> from BPP University College School of Health explore how aspiring and current doctors can make the most of the time that they have, become more efficient in their day to day activities, and achieve a better work-life balance
Doctors and managers: clash of values
Authors: David Oliver
Journal: BMJ (2009)

Dr Iftikhar Ahmed has produced a well balanced and researched piece that encourages more understanding on both sides between doctors and managers ( BMJ 2009;338:CR133-4). It is perhaps only when doctors engage in management roles—for instance, as clinical directors—that they begin to gain an understanding of the pressures, responsibilities, and roles of their …
Implant placement in the esthetic area: criteria for positioning single and multiple implants
Authors: Tiziano Testori, Tommaso Weinstein, Fabio Scutellà, Hom‐Lay Wang, Giovanni Zucchelli
Journal: Periodontology 2000 (2018)

Patient expectations from implant treatment have changed over the years and esthetics plays an important role in defining what is now called success of rehabilitation. Of the many factors that influence the outcome of the rehabilitation, the two main ones are the bone and soft-tissue deficiencies at the intended implant site. Many surgical approaches are described in terms of timing of implant placement and management of regenerative procedures. The aim of this article is to discuss the different implant placement alternatives in the esthetic area, in particular: (i) the timing of implant placement/regenerative procedures/skeletal growth/altered passive eruption; (ii) the correct three-dimensional position of the fixture between the cuspids and in the premolar area; (iii) multiple missing teeth in the esthetic area with single tooth/pontic or cantilevered options/prosthetic compensation; (iv) placement of implants into infected sites; and (v) the influence of abutment and crown morphology on implant position. Combining our long-standing clinical experience and the pertinent literature, the following conclusions can be drawn: Immediate implant placement can be a successful procedure in terms of esthetics but it is technique sensitive and requires an experienced team. Immediate placement is less traumatic to the patient as fewer surgical procedures are involved and patients tend to prefer this clinical approach with regards to quality of life. The diagnostic phase is of utmost importance, with not only bone and soft tissue deficiencies being addressed but also: skeletal growth, dental/implant soft tissue parameters such as altered passive eruption and the morphology of the roots adjacent to the edentulous area. Post-extraction immediate loading is feasible in infected sites. The correct position of the fixture should follow widely accepted guidelines but the abutment morphologies play a role in the vestibular/palatal position of the implant. The long axis of the implant, aiming at the incisal edge of the future restorations, is the most appropriate implant position when a shoulder-less abutment is used and allows a restorative crown morphology with a cervical contour resembling a natural tooth. The use of a shoulder-less abutment gives more space for the tissue to grow compared with the traditional abutment with shoulder finish line.
<i>I am currently working as a staff grade at the top of the pay scale with discretionary points. Will I have to take a pay cut if I apply for a specialist registrar rotation?</i>
Authors: Simon Eccles
Journal: BMJ (2004)

Got a career or related problem that needs answering? Can't find the right person to point you in the right direction? Log on to the Advice Zone ( www.bmjcareers.com/advicezone ) for reliable medical careers advice. You can post a question or see if one of our 300 advisers has already answered a similar question. Here is a selection of questions and answers posted on the site.
Postgraduate diploma in health research
Authors: Anita Sainsbury
Journal: BMJ (2005)

Most people on the course are from a medical background or professions allied to medicine, including nursing, dentistry, and physiotherapy.

2003-4, in my third and fourth years as a specialist registrar.

As an introduction to research concepts before starting an MD.

Each module required about 25 contact hours and 75 hours of private study, which included completing assignments and background reading. Many of the assignments were partly done during practical sessions, …
Regulation of DNA double strand break repair by EGF and VEGF signalling reveals Akt to be a critical therapeutic target in glioblastoma
Authors: Natividad Gomez-Roman, Ming Yao Chong, Katrina Stevenson, Lesley Gilmour, Anthony Chalmers
Journal: Neuro-Oncology (2018)

Glioblastoma (GBM) is currently incurable. Its radioresistance has been attributed to a subpopulation of cells termed ‘GBM stem-like cells’ characterised by multipotentiality and tumorigenicity. The discrepancy between pre-clinical and clinical effects of molecular targeted agents on radiosensitivity indicates that 2D in vitro models of GBM do not recapitulate the clinical scenario. In a 3D model developed in our laboratory, EGFR inhibitors failed to enhance radiosensitivity recapitulating their lack of efficacy in the clinic, contrasting with their radiosensitising activity in 2D cultures. Conversely, inhibition of VEGF signalling caused significant radiosensitisation of 3D cultures but had no effect in 2D conditions. The critical role of the DNA damage response in mediating these effects is illustrated by the consistent correlation between radiosensitivity, unrepaired double-strand breaks (γH2AX foci), mitotic catastrophe and micronuclei in both 2D and 3D models. Further investigation revealed unrepaired DSB to be associated with delayed resolution of phosphorylated DNA-PKcs nuclear foci and reduced formation of Rad51 foci. Hence in 2D conditions, EGFR signalling appeared to promote efficient non-homologous end-joining (NHEJ) repair, while in 3D conditions this process was dependent on VEGF signalling. Motivated by previous reports that radiation induced EGFR signalling promotes NHEJ via Akt mediated phosphorylation of DNA-PKcs, we investigated the role of Akt signalling in 2D and 3D systems. Specific inhibition of Akt using the small molecule inhibitor MK-2206 or Akti knockdown increased radiation sensitivity in both 2D and 3D models to a similar extent as EGFR or VEGF inhibition respectively. In keeping with this, phosphorylation of Akt was EGFR dependent in 2D GSC cultures but VEGF dependent in the 3D model. MK-2206 induced radiosensitivity was correlated with increased unrepaired DSBs and extended mouse survival in an U87MGLuc2 orthotopic model compared to radiation only. Our data identify Akt as a promising therapeutic target in combination with radiation for GBM.
GP recruitment is low in areas that struggle to recruit trainees
Authors: Abi Rimmer
Journal: BMJ (2015)

Areas of the UK that struggle to fill GP training places also struggle to garner interest in local GP jobs, data on jobs advertised with BMJ Careers show.

Figures published earlier this month by the General Practice National Recruitment Office showed that only 72% of GP training posts across the UK were filled after the first round of recruitment.1 The data showed that there was also wide regional variation in the extent to which local training programme directors were able to attract trainees to GP training posts. 

This pattern is mirrored in figures gathered by BMJ Careers. These data show that there is similar regional variation in the amount of serious interest in GP jobs, including partnership vacancies, salaried roles, and locum posts.2

In the East Midlands, for example, only 36% of …
Similar efficacy, safety and immunogenicity of adalimumab biosimilar BI 695501 and Humira reference product in patients with moderately to severely active rheumatoid arthritis: results from the phase III randomised VOLTAIRE-RA equivalence study
Authors: Stanley B Cohen, Alberto Alonso-Ruiz, Piotr A Klimiuk, Eric C Lee, Nuala Peter, Ivo Sonderegger, Deepak Assudani
Journal: Annals of the Rheumatic Diseases (2018)

To demonstrate clinical equivalence of adalimumab biosimilar candidate BI 695501 with Humira.
Esthetics in periodontics and implantology
Authors: Giovanni Zucchelli, Praveen Sharma, Ilham Mounssif
Journal: Periodontology 2000 (2018)

Periodontal plastic surgery comprises an increasing part of clinical periodontology. Clinical trials have traditionally used professionals to judge esthetic outcome, and few studies have addressed patient needs and requests (true end points). Development of universally accepted and validated methods for professional esthetic assessment, together with standardized questionnaires for patient-perceived outcome, may help to provide better insights into the true needs and benefits of periodontal and implant-associated plastic surgery. In this volume of Periodontology 2000, experienced researchers and clinicians from different subdisciplines of periodontology evaluate: treatment of gingival recession with or without papilla elevation; clinical crown lengthening in the natural dentition and in prosthodontic preparative treatment; periodontal regeneration around natural teeth; and soft-tissue augmentation in edentulous areas. Similarly, experts in different areas of implant science address esthetic outcomes with single and multiple implant rehabilitation, alveolar ridge preservation, implant positioning and immediate implant placement in the esthetic zone.
Learning statistics online
Authors: Munier Hossain
Journal: BMJ (2007)

Like it or not, statistics forms an essential part of the medical literature. As competition for training jobs gets harder it is becoming essential to have publications in your curriculum vitae. A basic understanding of statistics is vital for deciding the right research methods and analysing results.

— www.bmj.com/statsbk/If you want to start from scratch this one's for you. This is the web version of the ninth edition of a best selling introductory textbook now in the tenth edition in print. It's clutter free and …
PREVALENCE OF LAYERED TESTING FOR CORONARY ARTERY DISEASE AND COST ANALYSIS OF CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY AS THE INITIAL DIAGNOSTIC TEST
Authors: Eileen Hu-Wang, Tushar Acharya, Bharath Sathya, Faraz Kureshi, Shirley Rollison, Kathie Bronson, W. Patricia Bandettini, Sujata Shanbhag, Marcus Chen
Journal: Journal of the American College of Cardiology (2018)