tbuckley/cabot-search huggingface dataset:
Abstract P6-01-08: Identifying metastatic drivers in patient derived xenograft models of triple negative breast cancer
Authors: E Powell, J Shao, T Tieu, M Peoples, C Bristow, G Manyam, S Cai, Y Tu, JR Edwards, TP Heffernan, D Piwnica-Worms, H Liang, H Piwnica-Worms
Journal: Cancer Research (2017)

Abstract Metastases are responsible for the vast majority of deaths due to breast cancer. Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high rates of metastasis and poor response to chemotherapy. We are using patient derived xenograft (PDX) models of TNBC to identify drivers of TNBC metastasis. Using these models, we demonstrated that human breast tumors are capable of completing all stages of the metastatic cascade in mice, and metastatic lesions are observed in organs normally found in patients with metastatic breast cancer including lung, liver, bone, brain and lymph nodes. Lentiviral transduction was employed to express both bioluminescent and fluorescent proteins in three distinct PDX models of TNBC. In this way, metastatic lesions can be isolated using bioluminescent imaging and circulating tumor cells (CTCs) are isolated by flow cytometry. A lung metastasis gene expression signature was generated and comprehensive gain-of-function screens are being conducted in vivo to validate this signature and identify functional drivers of TNBC metastasis. Citation Format: Powell E, Shao J, Tieu T, Peoples M, Bristow C, Manyam G, Cai S, Tu Y, Edwards JR, Heffernan TP, Piwnica-Worms D, Liang H, Piwnica-Worms H. Identifying metastatic drivers in patient derived xenograft models of triple negative breast cancer [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P6-01-08.
Biochemical and Pharmacologic Profiling of a Novel Dual Acting Antithrombin Agent with Antiprotease and Antiplatelet Actions. Hematologic Implications.
Authors: Jawed Fareed, D. Hoppensteadt, W. Haque, J. Diakur, W. Jeske, M. Florian-Kujawski, J. Maddineni, F. Baltasar, B. Neville, J. M. Walenga
Journal: Blood (2005)
Helping Patients Decide on Treatment Options for Actinic Keratosis—Living in Cryo Nation
Authors: Jorge Roman, David J. Elpern
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Individualized Breast Cancer Characterization through Single-Cell Analysis of Tumor and Adjacent Normal Cells
Authors: Manjushree Anjanappa, Angelo Cardoso, Lijun Cheng, Safa Mohamad, Andrea Gunawan, Susan Rice, Yan Dong, Lang Li, George E. Sandusky, Edward F. Srour, Harikrishna Nakshatri
Journal: Cancer Research (2017)

There is a need to individualize assays for tumor molecular phenotyping, given variations in the differentiation status of tumor and normal tissues in different patients. To address this, we performed single-cell genomics of breast tumors and adjacent normal cells propagated for a short duration under growth conditions that enable epithelial reprogramming. Cells analyzed were either unselected for a specific subpopulation or phenotypically defined as undifferentiated and highly clonogenic ALDH+/CD49f+/EpCAM+ luminal progenitors, which express both basal cell and luminal cell-enriched genes. We analyzed 420 tumor cells and 284 adjacent normal cells for expression of 93 genes that included a PAM50-intrinsic subtype classifier and stemness-related genes. ALDH+/CD49f+/EpCAM+ tumor and normal cells clustered differently compared with unselected tumor and normal cells. PAM50 gene-set analyses of ALDH+/CD49f+/EpCAM+ populations efficiently identified major and minor clones of tumor cells, with the major clone resembling clinical parameters of the tumor. Similarly, a stemness-associated gene set identified clones with divergent stemness pathway activation within the same tumor. This refined expression profiling technique distinguished genes truly deregulated in cancer from genes that identify cellular precursors of tumors. Collectively, the assays presented here enable more precise identification of cancer-deregulated genes, allow for early identification of therapeutically targetable tumor cell subpopulations, and ultimately provide a refinement of precision therapeutics for cancer treatment. Cancer Res; 77(10); 2759-69. ©2017 AACR.
Hard to Conceive
Authors: John J. Ross, Julie H. Levison, Robert L. Barbieri
Journal: New England Journal of Medicine (2010)

A 31-year-old woman originally from Nepal presented to her primary care physician after failing to become pregnant despite having regular unprotected intercourse for the past 18 months. Her menarche had occurred at 13 years of age. Her menses lasted for 6 or 7 days, occurred regularly every 4 weeks, and were associated with typical premenstrual symptoms. She had no history of . . .
2017 ACC/AHA/HFSA/ISHLT/ACP Advanced Training Statement on Advanced Heart Failure and Transplant Cardiology (Revision of the ACCF/AHA/ACP/HFSA/ISHLT 2010 Clinical Competence Statement on Management of Patients With Advanced Heart Failure and Cardiac Transplant)
Authors: Mariell Jessup, Mark H. Drazner, Wendy Book, Joseph C. Cleveland, Ira Dauber, Susan Farkas, Mahazarin Ginwalla, Jason N. Katz, Peggy Kirkwood, Michelle M. Kittleson, Joseph E. Marine, Paul Mather, Alanna A. Morris, Donna M. Polk, Antoine Sakr, Kelly H. Schlendorf, Esther E. Vorovich
Journal: Journal of the American College of Cardiology (2017)
Is It Time to Abandon the Routine Pelvic Examination in Asymptomatic Nonpregnant Women?
Authors: Colleen McNicholas, Jeffrey F. Peipert
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical and Correlative Results of a Phase 1 Study of Cerdulatinib (PRT062070) a Dual SYK/JAK Inhibitor in Patients with Relapsed/Refractory B Cell Malignancies
Authors: Paul A Hamlin, Ian Flinn, Nina wagner-Johnston, Jan A Burger, Glenn Michelson, Anjali Pandey, Matt Birrell, Greg P. Coffey, Janet M Leeds, John T. Curnutte, Manish R. Patel
Journal: Blood (2015)
What strategies can be used to effectively reduce the risk of concussion in sport? A systematic review
Authors: Carolyn A Emery, Amanda M Black, Ash Kolstad, German Martinez, Alberto Nettel-Aguirre, Lars Engebretsen, Karen Johnston, James Kissick, David Maddocks, Charles Tator, Mark Aubry, Jiří Dvořák, Shinji Nagahiro, Kathryn Schneider
Journal: British Journal of Sports Medicine (2017)

Aim or objective To examine the effectiveness of concussion prevention strategies in reducing concussion risk in sport. Design Systematic review according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. Data sources Eleven electronic databases searched and hand-search of references from selected studies. Eligibility criteria for selecting studies The following were the study inclusion criteria: (1) contained original human research data; (2) investigated an outcome of concussion or head impact; (3) evaluated a concussion prevention intervention; (4) included sport participants; (5) analytical study designand (6) peer-reviewed. The following were the exclusion criteria: (1) review articles, case series or case studies and (2) not in English. Results The studies selected (n=48) provided evidence related to protective gear (helmets, headgear, mouthguards) (n=25), policy and rule changes (n=13) and other interventions (training, education, facilities) (n=10). Meta-analyses demonstrate a combined effect of a 70% reduction (incidence rate ratio (IRR)=0.3 (95% CI: 0.22 to 0.41)) in concussion risk in youth ice hockey leagues where policy disallows body checking, and the point estimate (IRR=0.8 (95% CI: 0.6 to 1.1)) suggests a protective effect of mouthguards in contact and collision sport (basketball, ice hockey, rugby). Summary/conclusions Highlights include a protective effect of helmets in skiing/snowboarding and the effectiveness of policy eliminating body checking in youth ice hockey. Future research should examine mouthguards in contact sport, football helmet padding, helmet fit in collision sport, policy limiting contact practice in youth football, rule enforcement to reduce head contact in ice hockey and soccer, ice surface size and board/glass flexibility in ice hockey and training strategies targeting intrinsic risk factors (eg, visual training). Systematic review registration PROSPERO 2016:CRD42016039162
Clonotype Switching Indicates Propensity for Clonal Outgrowth From Diverse Components of the T Cell Repertoire In T Cell Large Granular Lymphocyte Leukemia.
Authors: Michael J. Clemente, Marcin W. Wlodarski, Aaron D. Viny, Mohammed Shaik, Nelli Bejanyan, Sanjay R. Mohan, Hideki Makishima, Alan E. Lichtin, Eric D. Hsi, Ronald L. Paquette, Thomas P. Loughran, Jaroslaw P. Maciejewski
Journal: Blood (2010)
The Prognostic Role of Hypertrabeculation By Cardiac Magnetic Resonance in Thalassemia Intermedia Patients
Authors: Alessia Pepe, Francesca Macaione, Pietro Giuliano, Laura Pistoia, Angelica Barone, Roberto Sarli, Gaetano Roccamo, Aurelio Maggio, Vincenzo Positano, Stefania Renne, Pasquale Assennato, Antonella Meloni
Journal: Blood (2016)
Guideline: In acute gout, steroids, NSAIDs, or low-dose colchicine recommended; lifestyle changes not supported
Authors: Venkataraman Palabindala
Journal: Annals of Internal Medicine (2017)

ACP Journal Club21 February 2017Guideline: In acute gout, steroids, NSAIDs, or low-dose colchicine recommended; lifestyle changes not supportedVenkataraman Palabindala, MDVenkataraman Palabindala, MDUniversity of Mississippi Medical Center, Jackson, Mississippi, USA (V.P.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2017-166-4-014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationQaseem A, Harris RP, Forciea MA. Management of acute and recurrent gout: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2017;166:58-68. https://pubmed.ncbi.nlm.nih.gov/27802508Clinical Impact RatingsGIM/FP/GP: Rheumatology: Reference1 Khanna D, Fitzgerald JD, Khanna PP, et al; American College of Rheumatology. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken). 2012;64:1431-46. [PMID: 23024028] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Mississippi Medical Center, Jackson, Mississippi, USA (V.P.)This article was published at Annals.org on 7 February 2017. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 February 2017Volume 166, Issue 4Page: JC14KeywordsColchicineDrugsGoutGrading of Recommendations Assessment Development and EvaluationNSAIDsObservational studiesRheumatologySteroidsSystematic reviewsTreatment guidelines ePublished: 21 February 2017 Issue Published: 21 February 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Twenty years and counting: epidemiology of an outbreak of isoniazid-resistant tuberculosis in England and Wales, 1995 to 2014
Authors: Catherine M Smith, Suzan C M Trienekens, Charlotte Anderson, Maeve K Lalor, Tim Brown, Alistair Story, Hannah Fry, Andrew C Hayward, Helen Maguire
Journal: Eurosurveillance (2017)

An outbreak of isoniazid-resistant tuberculosis first identified in London has now been ongoing for 20 years, making it the largest drug-resistant outbreak of tuberculosis documented to date worldwide. We identified culture-confirmed cases with indistinguishable molecular strain types and extracted demographic, clinical, microbiological and social risk factor data from surveillance systems. We summarised changes over time and used kernel-density estimation and k-function analysis to assess geographic clustering. From 1995 to 2014, 508 cases were reported, with a declining trend in recent years. Overall, 70% were male (n = 360), 60% born in the United Kingdom (n = 306), 39% white (n = 199), and 26% black Caribbean (n = 134). Median age increased from 25 years in the first 5 years to 42 in the last 5. Approximately two thirds of cases reported social risk factors: 45% drug use (n = 227), 37% prison link (n = 189), 25% homelessness (n = 125) and 13% alcohol dependence (n = 64). Treatment was completed at 12 months by 52% of cases (n = 206), and was significantly lower for those with social risk factors (p &lt; 0.05), but increased over time for all patients (p &lt; 0.05). The outbreak remained focused in north London throughout. Control of this outbreak requires continued efforts to prevent and treat further active cases through targeted screening and enhanced case management.
Imatinib plasma concentrations during long-term effective treatment of metastatic gastrointestinal stromal tumor.
Authors: Akira Sawaki, Kazuki Inaba, Katsumi Hayashi, Hiroshi Kanie, Toshihiro Owaki, Tsukasa Kimata, Masato Suzuki, Aya Kawachi, Etsuro Orito
Journal: Journal of Clinical Oncology (2013)

10543 Background: Imatinib concentrations at one month after the start of imatinib have shown an association with clinical benefit in pts with gastrointestinal stromal tumors (GISTs) and a significant decrease of 30% within twelve months. This retrospective study investigated imatinib plasma concentrations in pts with metastatic GISTs in a long-term (≥2 years) effective treatment. Methods: 31 metastatic GIST pts, who had been treated with imatinib for two or more years in our hospital, were enrolled in this study. 11 pts were excluded because of adjuvant setting (n=5) and rejection to concentration testing (n=6). 20 pts were included in this study. GISTs were immunohistochemically diagnosed, and radiologically assessed as effective GIST by Choi’s criteria without relapse. Results: 10 pts were male, median age was 63 years (range, 31-84), and median imatinib exposure time was 3.5 year (range, 2-12). The median plasma concentration was 1093 ng/ml (range, 417-2091) and minimal level after at least five years was 789 ng/ml. imatinib concentration has no significant correlation with age, gender, gastrectomy, leukocyte count, platelet count, serum albumin, serum creatinine, cholesterol, and duration of imatinib exposure. Body surface area (BSA) isn’t directly associated with imatinib dose; median BSA of pts taking 300mg imatinib was 1.560 m 2 and that of 400mg 1.595 m 2 , but minimal BSA of 400mg imatinib was 1.560 m 2 , which is higher than the minimum of 300mg. Conclusions: Plasma concentrations of long-term (≥2 years) response pts was scattered, but one of longer-term (≥5 years) response pts were more than 789 ng/ml. Effective imatinib plasma level might be more than 789 ng/ml and 400mg imatinib may be recommended for a pt with BSA(≥1.56 m 2 ).
Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential
Authors: François-Xavier Briand, Audrey Schmitz, Katell Ogor, Aurélie Le Prioux, Cécile Guillou-Cloarec, Carole Guillemoto, Chantal Allée, Marie-Odile Le Bras, Edouard Hirchaud, Hélène Quenault, Fabrice Touzain, Martine Cherbonnel-Pansart, Evelyne Lemaitre, Céline Courtillon, Hélène Gares, Patrick Daniel, Alexandre Fediaevsky, Pascale Massin, Yannick Blanchard, Nicolas Eterradossi, Sylvie van der Werf, Véronique Jestin, Eric Niqueux
Journal: Eurosurveillance (2017)

Several new highly pathogenic (HP) H5 avian influenza virus (AIV) have been detected in poultry farms from south-western France since November 2015, among which an HP H5N1. The zoonotic potential and origin of these AIVs immediately became matters of concern. One virus of each subtype H5N1 (150169a), H5N2 (150233) and H5N9 (150236) was characterised. All proved highly pathogenic for poultry as demonstrated molecularly by the presence of a polybasic cleavage site in their HA protein - with a sequence (HQRRKR/GLF) previously unknown among avian H5 HPAI viruses - or experimentally by the in vivo demonstration of an intravenous pathogenicity index of 2.9 for the H5N1 HP isolate. Phylogenetic analyses based on the full genomes obtained by NGS confirmed that the eight viral segments of the three isolates were all part of avian Eurasian phylogenetic lineage but differed from the Gs/Gd/1/96-like lineage. The study of the genetic characteristics at specific amino acid positions relevant for modulating the adaptation to and the virulence for mammals showed that presently, these viruses possess most molecular features characteristic of AIV and lack some major characteristics required for efficient respiratory transmission to or between humans. The three isolates are therefore predicted to have no significant pandemic potential.
Patient-Reported Quality of Life In Elderly, Newly Diagnosed Multiple Myeloma Patients Treated with Bortezomib-Based Regimens: Results From the Phase 3b UPFRONT Study
Authors: Ruben Niesvizky, Ian W. Flinn, Robert M. Rifkin, Nashat Y Gabrail, Veena Charu, Billy Clowney, James Essell, Yousuf A Gaffar, Thomas A. Warr, Rachel Neuwirth, Deyanira Corzo, James A Reeves
Journal: Blood (2010)
A New Oral Aniticoagulant, Dabigatran Etexilate, Is Effective and Safe in Preventing Venous Thromboembolism after Total Knee Replacement Surgery (The RE-MODEL Trial).
Authors: Bengt I. Eriksson, Ola E. Dahl, Cornelis N. van Dijk, Simon P. Frostick, Andreas A. Kurth, Nadia Rosencher, Janet Schnee, Rohan Hettiarachchi, Anita V. Christiansen, Stefan Hantel, Harry R. Büller
Journal: Blood (2006)
Results of a Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CXD101: Preliminary Safety and Activity in Relapsed or Refractory Hodgkin and Non-Hodgkin Lymphoma Patients
Authors: Toby A. Eyre, Graham P. Collins, Avinash Gupta, Semira Sheikh, Victoria Woodcock, John Whittaker, Lai Mun Wang, Elizabeth Soilleux, Finn Tysoe, Richard Cousins, Nick La Thangue, David Kerr, Mark R. Middleton
Journal: Blood (2016)
Effects of dietary potassium on the hemodynamics and plasma norepinephrine kinetics in patients with essential hypertension.
Authors: Hirofumi Ohashi, Yukio Miura, Shinobu Kimura, Yuki Ishizuka, Takashi Sugawara, Shunichi Toriyabe, Takao Noshiro, Masaki Takahashi, Naoki Sano, Hiroshi Watanabe, Kaoru Yoshinaga
Journal: Circulation (1985)

The effects of dietary potassium on the hemodynamics and plasma norepinephrine (NE) kinetics were studied in 10 patients with borderline hypertension. Potassium supplement (96 mEq daily for 5-7 days) induced a significant (p less than 0.05) fall in blood pressure and a slight decrease in cardiac output. Both urine volume and urinary sodium excretion increased significantly (p less than 0.05) for a first few days following the potassium supplement. The baseline values of the half-time of the rapid NE removal from plasma was significantly delayed in the hypertensive patients (1.05 +/- 0.06 min, p less than 0.05) when compared with those (0.88 +/- 0.04) in normal controls. Potassium supplement induced a significant rise in both plasma NE levels and NE outflow rate (p less than 0.01) in the hypertensive patients, while their half-times were significantly shortened (0.89 +/- 0.07 min, p less than 0.01). The pressor responsiveness to exogenously infused NE tended to diminish during the potassium supplement. These findings indicate that a high potassium intake might accelerate the slowed neuronal NE uptake in the hypertensive patients, while a potassium-induced fall in blood pressure might exert a baroreflex stimulation of NE release. As a net result, an increased NE outflow into the circulation has been confirmed. It is likely that a natriuresis-induced volume contraction might be a predominant factor responsible for the early reduction of blood pressure during the high potassium intake.