CONCURRENT OBSERVATIONS OF BEHAVIOR CHANGES AND OF ADRENOCORTICAL VARIATIONS IN A CYCLOTHYMIC PATIENT DURING A PERIOD OF 12 MONTHS
Authors: N D RIZZO, H M FOX, J C LAIDLAW, G W THORN
Journal: Annals of Internal Medicine (1954)

Article1 October 1954CONCURRENT OBSERVATIONS OF BEHAVIOR CHANGES AND OF ADRENOCORTICAL VARIATIONS IN A CYCLOTHYMIC PATIENT DURING A PERIOD OF 12 MONTHSNICHOLAS D. RIZZO, M.D., HENRY M. FOX, M.D., JOHN C. LAIDLAW, M.D., GEORGE W. THORN, M.D., F.A.C.P.NICHOLAS D. RIZZO, M.D.Search for more papers by this author, HENRY M. FOX, M.D.Search for more papers by this author, JOHN C. LAIDLAW, M.D.Search for more papers by this author, GEORGE W. THORN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-4-798 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI. REVIEW OF LITERATUREII. PSYCHOLOGIC BACKGROUNDThe PatientOveractivityDepressionProjectionFamilyPrevious EpisodesHospitalization for DepressionInterval Between Hospitalization for Depression and Re-admissionIII. CLINICAL COURSE DURING 12 MONTHS OF OBSERVATIONIV. RELATIONSHIP TO PSYCHOTHERAPISTV. PSYCHOLOGIC INTERPRETATIONVI. BIOCHEMICAL STUDY DURING 12 MONTHS OF OBSERVATIONMethodSummary of Biochemical FindingsVII. INTERPRETATION OF BIOCHEMICAL FINDINGSVIII. PSYCHOENDOCRINOLOGIC CORRELATIONEmotional drives and phantasy determine the response of the psychotic individual to a greater extent than is true of the non-psychotic, who is more directly influenced by external reality. Measurable biochemical changes presumably reflect this crucial shift in the...Bibliography1. FoxGifford HMS: Psychological responses to ACTH and cortisone, Psychosom. Med. 15: 614, 1953. CrossrefMedlineGoogle Scholar2. Jacobson E: Contribution to the metapsychology of cyclothymic depression, in Affective disorders, Phyllis Greenacre, Editor, 1953, International Universities Press, Inc., New York, pp. 49-83. Google Scholar3. Cleghorn RA: A short history of the relationship of endocrinology to psychiatry, Internat. Rec. Med. 166: 175, 1953. Google Scholar4. Hoagland H: Some considerations of adrenocortical physiology in relation to the psychoses, Internat. Rec. Med. 166: 183, 1953. Google Scholar5. Altschule MD: Adrenal function in some psychiatric disorders, Internat. Rec. Med. 166: 190, 1953. Google Scholar6. Reiss M: Investigations into psychoendocrinology, Internat. Rec. Med. 166: 196, 1953. Google Scholar7. Mirsky IA: Psychologic and endocrinologic interrelations, Internat. Rec. Med. 166: 204, 1953. Google Scholar8. Rochlin GN: The disorder of depression and elation, J. Am. Psychoanalytic A. 1: 438, 1953. CrossrefMedlineGoogle Scholar9. Lewin BD: The psychoanalysis of elation, 1950, W. W. Norton & Company, New York. Google Scholar10. Katan M: Mania and the pleasure principle: primary and secondary symptoms, in Affective disorders, Phyllis Greenacre, Editor, 1953, International Universities Press, Inc., New York, pp. 140-209. Google Scholar11. ReddyJenkinsThorn WDGW: Estimation of 17-hydroxycorticoids in urine, Metabolism 1: 511, 1952. MedlineGoogle Scholar12. DrekterHeislerScismSternPearsonMcGavack IJAGRSSTH: The determination of urinary steroids. 1. The preparation of pigment free extracts and a simplified procedure for the estimation of total 17-ketosteroids, J. Clin. Endocrinol. and Metabolism 12: 55, 1952. CrossrefGoogle Scholar13. HoltorffKoch AFFC: The colorimetric estimation of 17-ketosteroids and their application to urine extracts, J. Biol. Chem. 135: 377, 1940. CrossrefGoogle Scholar14. HillsForshamFinch AGPHCA: Changes in circulating leukocytes induced by the administration of pituitary adrenocorticotrophic hormone (ACTH) in man, Blood 3: 755, 1948. CrossrefMedlineGoogle Scholar15. AnsonMirsky MDIA: The estimation of pepsin with hemoglobin, J. Gen. Physiol. 16: 59, 1943. CrossrefGoogle Scholar16. MirskyBlockOsherBroh-Kahn IASSRH: Uropepsin excretion in man. I. The source, properties and assay of uropepsin, J. Clin. Investigation 27: 818, 1948. CrossrefGoogle Scholar17. Bucher GR: Uropepsin: a review of the literature and report of some experimental findings, Gastroenterology 8: 627, 1947. MedlineGoogle Scholar18. SpiroReifensteinGray HMRWSJ: The effect of adrenocorticotropic hormone upon uropepsin excretion, J. Lab. and Clin. Med. 35: 899, 1950. MedlineGoogle Scholar19. ThornJenkinsLaidlaw GWDJC: The adrenal response to stress in man, Recent Progress in Hormone Therapy 8: 171, 1953. Google Scholar20. KelleyElyRaile VCRSRB: Hormone patterns in patients with congenital adrenal hyperplasia, Pediatrics 12: 541, 1953. MedlineGoogle Scholar21. Venning EH: Adrenal function in pregnancy, Endocrinology 29: 203, 1946. CrossrefGoogle Scholar22. Abraham K: A short study of the development of the libido, viewed in the light of mental disorders, Chapter XXVI in Selected papers of Karl Abraham, Ernest Jones, Editor, 1927, The Hogarth Press, London, p. 418. Google Scholar23. Bibring E: The mechanism of depression, in Affective disorders, Phyllis Greenacre, Editor, 1953, International Universities Press, Inc., New York, pp. 13-48. Google Scholar24. Margolin SG: Genetic and dynamic psychophysiological determinants of the pathophysiological processes, Monograph Series of the Boston Psychoanalytic Society and Institute, No. 1. The Psychosomatic Concept in Psychoanalysis, Felix Deutsch, Editor, 1953, International Universities Press, Inc., New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication March 1, 1954.From the Medical Clinic of the Peter Bent Brigham Hospital and the Departments of Psychiatry and Medicine, Harvard Medical School, Boston, Massachusetts.†This investigation was supported in part by the Medical Research and Development Division, Office of the Surgeon General, Department of the Army, under Contract No. DA-49-007-MD-213, in part by a grant from the Ford Foundation, and in part by a research grant A-19 (C3) from the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service. 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