tbuckley/cabot-search huggingface dataset:
Hemostatic powder TC-325 in the management of upper and lower gastrointestinal bleeding: a two-year experience at a single institution
Authors: Yen-I Chen, Alan Barkun, Sabrina Nolan
Journal: Endoscopy (2014)

TC-325 is a novel endoscopic hemostatic powder. Our aim was to describe a single-center experience with the use of TC-325 in the upper and lower gastrointestinal tract, while for the first time attempting to determine how long the powder remains on a lesion.The charts of consecutive patients receiving TC-325 therapy between July 2011 and July 2013 were reviewed retrospectively. Primary endpoints included immediate hemostasis and early rebleeding (≤ 72 hours).Overall, 60 patients received 67 treatments with TC-325: 21 for nonmalignant nonvariceal upper gastrointestinal bleeding, 19 for malignant upper gastrointestinal bleeding, 11 for lower gastrointestinal bleeding, and 16 for intra-procedural bleeding. Immediate hemostasis was achieved in 66 cases (98.5 %), with 6 cases (9.5 %) of early rebleeding. No serious adverse events were noted. No TC-325 powder was identified in the 11 patients who underwent second-look endoscopy, performed within 24 hours in 4 patients.TC-325 appears safe and effective for managing bleeding in the upper and lower gastrointestinal tract with a variety of causes. The time during which the powder remains in the gastrointestinal tract is short, with complete elimination from the gastrointestinal tract as early as within 24 hours after use.
Abstract ADV07: Cancer simplified: A web-based learning system for newly-diagnosed patients.
Authors: Duncan Darrow
Journal: Cancer Research (2013)

Abstract Mission Statement: Improving the quality of care for cancer patients on the East End of Long Island by establishing the Nations’ largest free cancer counseling center with a regional focus. Initiatives: We provide psycho-social counseling to approximately 300 newly-diagnosed cancer patients each year with a professional staff that includes two oncology social workers, a clinical psychologist with a PhD and a registered nurse. We also author a unique book - Coping with Cancer on the East End - which is a “where-to-find-it” guide to regional cancer care resources. Poster Description: It will focus on a relatively new initiative at Fighting Chance which is called “Cancer Simplified.” This is, in essence, a “sister website.” It serves as a web-based learning system about the “ABCs” of cancer, using a PowerPoint platform and is intended for newly-diagnosed patients with a high school reading level. Cancer simplified aims to demystify the basic concepts of “what is cancer” using depiction instead of jargon-laden explanation. A deck of power point slides is augmented by a set of videos portraying Fighting Chance patients discussing their “cancer journeys.” Finally, a third element, known as “Easy Read,” drills into some of the largest cancer-helpful websites (like the ACS and NCCN) and takes the visitor directly to the most user-friendly pamphlets embedded in that site. Citation Format: Duncan Darrow. Cancer simplified: A web-based learning system for newly-diagnosed patients. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr ADV07. doi:10.1158/1538-7445.AM2013-ADV07
Abstract 3993: MiRNA-141 and methylation regulation of WNT signal pathway by suppressing <i>SOX17 i</i>n esophageal cancer
Authors: Mingzhou Guo, Yan Jia, Yunsheng Yang, Qimin Zhan, James G. Herman
Journal: Cancer Research (2012)

Abstract Purpose: WNT/β-catenin gene SOX17 was reported frequently methylated in colonic and hepatic cancer. To explore epigenetic changes of SOX17 as esophageal cancer marker and therapeutic target, epigenetic regulation and tumor suppressor function of SOX17 were analyzed in study. Experimental Design: Methylation specific PCR (MSP) was employed to examine SOX17 methylation in 8 esophageal cancer cell lines and 9 normal mucosa, 60 dysplasia and 169 cancer tissue. Semi-quantitative RT-PCR method was used to examine SOX17 expression before and after 5-aza-2′-deoxycytidine treatment of esophageal cancer cells. Expression of SOX17 and β-catenin were detected by immunohistochemistry (IHC) in esophageal cancer and adjacent tissue. Luciferase reporter assay, colony formation, transfection and western blotting were applied to analyze SOX17 function in WNT signal pathway. Prediction software and miRNAs related detection methods were preformed to evaluate miRNA regulation of SOX17. Results: SOX17 was silenced by promoter region methylation and reactivated by 5-aza-2′-deoxycytidine treatment in esophageal cancer cell lines. Loss of SOX17 expression and accumulation of β-catenin in nuclear and cytoplasm were associated with promoter region hypermethylation in esophageal cancer(test, P=0.0359, P=0.0105). Restoration of SOX17 expression inhibited β-catenin/TCF-dependent transcription and colony formation. The presence of SOX17 methylation correlated significantly with alcohol history in esophageal cancer(test, P=0.0057). MiR-141 was also found to down-regulate SOX17 expression and activated the WNT signal pathway. Conclusions: SOX17 is frequently methylated in esophageal cancer, and SOX17 expression is regulated both by miR-141 and promoter region methylation. Loss of SOX17 removes the normal inhibition of WNT signaling and promotes esophageal tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3993. doi:1538-7445.AM2012-3993
SC-03 * PAR1 INHIBITION SUPPRESSES A2B5-DEFINED GLIOMA PROGENITOR CELLS AND THEIR DERIVED GLIOMAS IN VIVO
Authors: R. Auvergne, A. Benraiss, C. Wu, A. Connell, A. Cornwell, M. Johnson, S. Dangelmajer, A. Quinones-Hinojosa, S. Goldman
Journal: Neuro-Oncology (2014)

In a comparison of gene expression by A2B5-defined glial tumor progenitor cells (TPCs) to glial progenitor cells derived from normal adult human brain (Cell Reports 3:2127-41, 2013), we found that the F2R gene encoding PAR1 was differentially over-expressed by TPCs isolated from primary gliomas at every stage of glioma progression. In this study, we therefore asked if PAR1 activation was causally associated with glioma progression. Lentiviral shRNAi knock-down of PAR1 inhibited the expansion and proliferation of glioma TPCs in vitro. We further found that the PAR-1 receptor antagonists SCH79797 and SCH530348 (vorapaxar) inhibited A2B5+ TPC expansion and migration in vitro. PAR1 knockdown also suppressed the tumorigenic potential of A2B5+ TPCs after transplantation into the brains of immunodeficient mice. In addition, mice given subcutaneous grafts of A2B5+ human glioma TPCs exhibited delayed tumor growth if treated with Vorapaxar, relative to xenografted control mice treated with only vehicle. Together, these data suggest that PAR1 may contribute to glioma progenitor expansion and tumor growth; as such, the abrogation of PAR1 signaling may contribute to the treatment of malignant glioma.
EFFICACY AND SAFETY OF LOW TO MEDIUM-DOSE VERSUS HIGH-DOSE ASPIRIN AFTER PERCUTANEOUS CORONARY INTERVENTION: EVIDENCE BEYOND THE CURRENT-OASIS 7 TRIAL
Authors: Chirag Bavishi, Vrinda Trivedi, Saurav Chatterjee, Jacqueline Tamis-Holland
Journal: Journal of the American College of Cardiology (2016)
Abstract P5-15-02: Characteristics and Prognosis of Patients Presenting with Isolated Axillary Nodal Metastases from Occult Breast Primary Carcinoma
Authors: JA Davidson, S Tyldesley, C Speers, R Woods, S. Chia
Journal: Cancer Research (2010)

Abstract Background: Patients presenting with isolated axillary metastatic carcinoma represent a potentially curable subset of patients. As there are no published randomized trials, literature concerning this uncommon clinical entity is limited to small retrospective reports. These vary widely with respect to the information collected, span a large time period during which diagnostic and therapeutic options have advanced considerably, and are largely without a contemporary control group. Methods: The British Columbia Breast Cancer Outcomes Unit (BCOU) database was searched to identify patients referred to the British Columbia Cancer Agency with a new diagnosis of isolated axillary metastatic cancer diagnosed between 2000 and 2005. Eligible patients were female, had pathological evidence of lymph node (LN) involvement but no evidence of a primary tumor or distant metastases on clinical workup. A series of control patients, with pathological T1 tumors and N1 involvement at presentation were selected from the BCOU database matched 3:1 for age, diagnosis year, tumor characteristics (histology, estrogen receptor status, HER2 status, and number of affected lymph nodes), and systemic treatment characteristics (adjuvant chemotherapy and/or endocrine therapy). Results: 36 patients were identified to form the primary axillary cohort. The controls consisted of 1,406 patients, of whom 106 were matched for the above characteristics. Patients in the primary axillary cohort were fairly well-distributed among all diagnosis years, and all tumors exhibited ductal histology. 26 (72%) were estrogen receptor-positive and 8 (22%) were known to be HER2-positive. 9 (25%) patients underwent mastectomy. 33 (92%) patients received radiation therapy and 19 (53%) did not undergo any breast surgery. With a median follow-up of 5.2 and 5.4 years for the primary axillary cohort and the matched controls, the BCSS was 93% and 88% respectively. There were no locoregional recurrences documented in the primary axillary cohort. Conclusions: This study represents one of the larger contemporary case control series of isolated axillary nodal presentations, demonstrating a good prognosis for this cohort of patients despite approximately half of the patients not having primary breast surgery. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P5-15-02.
Abstract 3684: Differential mechanisms of green tea polyphenols-induced apoptosis in human prostate cancer cells: Role of p53.
Authors: Karishma Gupta, Vijay S. Thakur, Natarajan Bhaskaran, Akbar Nawab, Melissa A. Babcook, Mark W. Jackson, Sanjay Gupta
Journal: Cancer Research (2013)

Abstract Tumor suppressor gene p53 is frequently inactivated in a variety of human cancers including prostate cancer and is associated with therapeutic resistance. We have previously demonstrated that green tea polyphenols (GTP) induces apoptosis in prostate cancer cells irrespective of p53 status (Carcinogenesis 33:377-84, 2012). However, the molecular mechanisms underlying these observations are not properly understood. In the present study we investigated the mechanisms of GTP-induced apoptosis in human prostate cancer cells with and without functional p53. Human prostate cancer LNCaP cells were stably transfected with short hairpin-53 (LNCaPshp53) and control vector (LNCaPshV), exposed to GTP in dose and time dependent manner. GTP exposure induced p53 stabilization and activation of downstream targets p21/waf1 and Bax in dose-dependent manner specifically in LNCaPshV cells. However, GTP-induced FAS upregulation through the activation of c-jun N-terminal kinase resulting in FADD phosphorylation, caspase-8 activation and truncation of BID leading to apoptosis was common in both LNCaPshV and LNCaPshp53 cells. In parallel, treatment of cells with GTP resulted in inhibition of survival pathway, mediated by Akt deactivation and loss of BAD phosphorylation more prominently in LNCaPshp53 cells. These distinct routes of cell death converged to a common pathway leading to loss of mitochondrial transmembrane potential, cytochrome c release and activation of terminal caspases resulting in PARP cleavage. GTP-induced apoptosis was attenuated with JNK inhibitor, SP600125 in both cell lines; whereas PI3K-Akt inhibitor, LY294002 resulted in increased cell death in LNCaPshp53 cells, establishing the role of two distinct pathways of GTP-mediated apoptosis. Furthermore, GTP exposure resulted in the inhibition of class I HDAC protein, accumulation of acetylated histone H3 in total cellular chromatin resulting in increased accessibility to bind with the promoter sequences of p21/waf1 and Bax irrespective of p53 status of cells, consistent with the effects elicited by HDAC inhibitor, trichostatin A. These results demonstrate that GTP induces prostate cancer cell death by two distinct mechanisms irrespective of p53 status, thus identifying for the first time through defined molecular targets for their chemopreventive and/or therapeutic actions. Citation Format: Karishma Gupta, Vijay S. Thakur, Natarajan Bhaskaran, Akbar Nawab, Melissa A. Babcook, Mark W. Jackson, Sanjay Gupta. Differential mechanisms of green tea polyphenols-induced apoptosis in human prostate cancer cells: Role of p53. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3684. doi:10.1158/1538-7445.AM2013-3684
OP0128-PARE ”Move to Improve” Fashion Show – Celebrating 2012 World Arthritis Day in Serbia
Authors: M. Kosanovic
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> More than 35 000 people in Serbia suffer from RA and more than a million suffer from some rheumatic or musculoskeletal disease. The Association of Rheumatic Diseases Patients of the Republic of Serbia (ORS) is a non-political, non-government and not-for-profit association of volunteers, aiming to: -provide information on prevention, symptoms, available treatments, rehabilitation options and resocialization to people suffering from rheumatic diseases so to better inform and improve the quality of life for people suffering from rheumatic diseases, and -raise social awareness and increase public understanding of the debilitating effects of rheumatic diseases. Every year our young association celebrates the 12th October - World Arthritis Day, as a central event in our activities calendar. In 2012, as part of the celebrations, we organized a fashion show. <h3>Objectives</h3> To explore and promote opportunities for designing clothes for people with rheumatic and musculoskeletal diseases. Through the visual effect of the fashion show, to bring general public closer to understanding the effects of rheumatic diseases. <h3>Methods</h3> The fashion show, themed "Move to Improve", was organized in cooperation with Belgrade Design District and Serbian Media, and was held during the 21<sup>st</sup> Maybelline Fashion selection manifestation. The models were volunteers - RMDs sufferers from ORS, who were escorted to the stage by journalists from First Serbian Television Station. The models wore clothes that had been specifically designed to suit people who cannot get dress themselves easily. <h3>Results</h3> Young designers did their job very well. They created simple, usable, modern clothes without small buttons, zippers, ribbons. The audience supported very kindly our brave models. The show attracted strong media attention, with reports from this event broadcast by 15 TV and 6 radio stations. Also, 17 printed media and 25 internet portals published stories about the show. Daily newspaper "Blic" organized a mini internet competition for the best fashion show during the whole fashion manifestation and more than 1.3 million visitors voted. With 62% of the votes, "Move to improve" won the prize for the best fashion show during a significant fashion manifestation in Serbia. <h3>Conclusions</h3> Our brave volunteers have shown that, in spite of their special needs, people with RMDs can and should follow and create fashion. They were seen and admired by very many people. The "Move to Improve" show is still talked about in Serbia – among ordinary people, health professionals and RMD sufferers … <h3>Disclosure of Interest</h3> None Declared
Successful EUS-guided drainage of the abscess in the abdominal cavity consequent to the gastric surgery: Report of a case
Authors: Matsui Noriaki, Akahoshi Kazuya, Motomura Yasuaki, Honda Kuniomi, Kubokawa Masaru, Endoh Shingo, Kimura Kazue, Watanabe Masayuki, Oya Masafumi, Nakamura Kazuhiko
Journal: Endoscopy (2011)

EUS-guided drainage has been known to be useful for drainage of pancreatic abscess. Little is described about the drainage for postoperative abscess. We report a successful EUS-guided drainage of the abscess in the abdominal cavity consequent to the gastric surgery. The patient was a 42 years old Japanese female who had been noted to have a submucosal tumor in the stomach close to the gastroesophageal junction. EUS-guided fine needle aspiration was performed and the pathological specimen revealed the GIST (gastrointestinal stromal tumor). Laparoscopic surgery was performed and the submucosal tumor was completely removed. Six days after the surgery the patient developed a high fever and the CT scan revealed an abscess formation in the left subphrenic space. Antibiotic treatment was carried out but the abscess had not been changed in size and the inflammation was not improved. Fourteen days after the surgery, EUS-guided abscess drainage was performed. EG530UT linear EUS scope (Fujifilm, Tokyo) was used. The hypoechoic lesion was recognized closed to the gastric wall, which was measured 7cm in maximal diameter. 19G Echo Tip Ultra endoscopic ultrasound needle (Cook Medical Endoscopy, IN, USA) was used to puncture the lesion, which was followed by the guide wire insertion (0.035 Jagwire, Boston Scientific Japan, Tokyo). Yellowish thick fluid came out from the lesion. Olympus KD-441Q needle knife (Olympus, Tokyo) was inserted over the guide wire and small incision was made. Once the needle knife was removed, a double pigtail tube (PBD-203–0703, Olympus, Tokyo) was inserted over the guide wire and placed into the lesion. Two days after the drainage, the fever had been lowered and the patient could discharge the hospital after seven days of the drainage procedure. Since the abscess became reduced in size, the stent was removed endoscopically after two months of the drainage procedure. The abscess disappeared on the endoscopic examination and the CT scan half a year later. EUS-guided drainage is also a promising procedure for the drainage of the abscess in the abdominal cavity consequent to the gastric surgery.
Hereditary Prothrombin Deficiency
Authors: Herman E. Kattlove, Sandor S. Shapiro, Morton Spivack
Journal: New England Journal of Medicine (1970)

Quantitative immunologic assay of the plasma of the proposita in a family with hereditary prothrombin deficiency demonstrated the defect to be due to an actual deficiency of the prothrombin molecule. The homozygous level of plasma prothrombin in this family is 25 per cent, and although this signifies a mild disorder, excessive bleeding did occur with surgical trauma. This was easily treated with whole-blood infusions. The mode of inheritance of this disorder appears to be autosomal, and its severity related to the gene dosage of the person affected.
A memorable patient: Unforeseen consequences
Authors: G. Igoe
Journal: BMJ (1999)

It was not long after I had arrived to take over a singlehanded practice in a rural part of Ireland that I first met Jean. I was struck by her big hands, jutting chin, and rather waxy facial features. The fact that she had hypertension and diabetes lent support to my clinical impression of acromegaly and that this had gone unnoticed in over three years of attendance at the hospital medical outpatient department added to the glow of satisfaction when the diagnosis was confirmed by an endocrinologist.
TCTAP C-022 Worst Fatal Cath Lab Case Scenario of 58 Years Old Male with Acute Inferoposterior Wall Myocardial Infarction Who Underwent Right Radial Primary PCI Followed by Subacute Scaffold Thrombosis After 36 Hours with Totally Occluded Abdominal Aorta
Authors: Mohan Mani
Journal: Journal of the American College of Cardiology (2015)
Abstract 2866: Western-type diet accelerates intestinal tumorigenesis in APCmin mice
Authors: Mikael Niku, Laura Sarantaus, Essi Päivärinta, Anu Heiman-Lindh, Minna Nyström, Marja Mutanen
Journal: Cancer Research (2010)

Abstract Lifestyle factors contribute to incidence of colorectal cancer (CRC). Western-type diet (WD) containing considerable amounts of saturated fat, sugar and red meat but little dietary fibre, vitamins, minerals and plant-derived nutrients is associated with elevated CRC risk. We have recently started to investigate the mechanisms explaining these observations using APCmin mice, a model of human familial adenomatous polyposis. METHODS: 12 APCmin mice were fed a WD (modified AIN-93G with high fat, low vitamin D and folate) for 10 weeks, starting at the age of 5 weeks. 14 control APCmin mice were fed the unmodified AIN-93G diet. The mice were sacrificed at the age of 15 weeks. The intestines were removed and opened. Number and size of adenomas were measured by blinded observers using a stereomicroscope. Tissue samples were collected from various locations of the small intestines, where the adenomas occur in this model. Epithelial renewal dynamics was analyzed in histologically normal areas of the mucosa. Paraffin tissue sections were immunostained using markers of cycling cells (Ki67 antigen), actually mitotic cells (phospho-histone H3) and apoptotic cells (cleaved caspase 3). The stained sections were analyzed using the ImageJ analysis software. RESULTS: The average number of adenomas in the small intestine was significantly higher in the WD mice (p=0.002). The average size of adenomas was not statistically different between the two diet groups. The heights of the actively cycling cell compartment (measured from the crypt base to the last Ki67-antigen positive cells in the villi) and the numbers of mitotic cells (measured as phospho-histone H3 positive cell count per area of mucosal base cross-section) were similar in both diet groups. The number of apoptotic cells (measured as cleaved caspase 3 positive bodies per area of intestinal tissue section) was also similar between the groups. CONCLUSIONS: In this model, Western-type diet accelerates tumor initiation but does not affect progression. The accelerated tumor initiation is not caused by changes in the general renewal dynamics of the epithelium, as the proliferation and apoptosis rates are not significantly affected. The results suggest that the epithelial stem or progenitor cells are more specifically targeted. To dissect the underlying mechanisms, we are currently analyzing the inflammatory and metabolic status of the intestinal mucosa. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2866.