tbuckley/cabot-search huggingface dataset:
Update: Interim Guidance for Health Care Providers Caring for Women of Reproductive Age with Possible Zika Virus Exposure — United States, 2016
Authors: Emily E. Petersen, Kara N.D. Polen, Dana Meaney-Delman, Sascha R. Ellington, Titilope Oduyebo, Amanda Cohn, Alexandra M. Oster, Kate Russell, Jennifer F. Kawwass, Mateusz P. Karwowski, Ann M. Powers, Jeanne Bertolli, John T. Brooks, Dmitry Kissin, Julie Villanueva, Jorge Muñoz-Jordan, Matthew Kuehnert, Christine K. Olson, Margaret A. Honein, Maria Rivera, Denise J. Jamieson, Sonja A. Rasmussen
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

CDC has updated its interim guidance for U.S. health care providers caring for women of reproductive age with possible Zika virus exposure to include recommendations on counseling women and men with possible Zika virus exposure who are interested in conceiving. This guidance is based on limited available data on persistence of Zika virus RNA in blood and semen. Women who have Zika virus disease should wait at least 8 weeks after symptom onset to attempt conception, and men with Zika virus disease should wait at least 6 months after symptom onset to attempt conception. Women and men with possible exposure to Zika virus but without clinical illness consistent with Zika virus disease should wait at least 8 weeks after exposure to attempt conception. Possible exposure to Zika virus is defined as travel to or residence in an area of active Zika virus transmission ( http://www.cdc.gov/zika/geo/active-countries.html), or sex (vaginal intercourse, anal intercourse, or fellatio) without a condom with a man who traveled to or resided in an area of active transmission. Women and men who reside in areas of active Zika virus transmission should talk with their health care provider about attempting conception. This guidance also provides updated recommendations on testing of pregnant women with possible Zika virus exposure. These recommendations will be updated when additional data become available.
Lack of Siglec-7 expression identifies a dysfunctional natural killer cell subset associated with liver inflammation and fibrosis in chronic HCV infection
Authors: Stefania Varchetta, Dalila Mele, Andrea Lombardi, Barbara Oliviero, Stefania Mantovani, Carmine Tinelli, Marta Spreafico, Daniele Prati, Serena Ludovisi, Giovanna Ferraioli, Carlo Filice, Alessio Aghemo, Pietro Lampertico, Floriana Facchetti, Francesca Bernuzzi, Pietro Invernizzi, Mario U Mondelli
Journal: Gut (2015)

<h3>Objective</h3> Sialic-acid-binding immunoglobulin-like lectin-7 (Siglec-7) is a natural killer (NK) cell inhibitory receptor associated with NK phenotypic and functional abnormalities in HIV-1 infection. We investigated the significance of NK-expressed and serum soluble Siglec-7 in relation to NK functional ability and parameters of liver necroinflammation and fibrosis in chronic HCV infection. <h3>Design</h3> NK-expressed and serum Siglec-7 were evaluated in 130 and 166 HCV-infected individuals by flow cytometry and ELISA, respectively. NK cell degranulation and cytokine secretion were determined by flow cytometry. 65 patients with chronic HBV infection, 84 with chronic biliary disorders and 168 healthy donors served as controls. <h3>Results</h3> Expression of Siglec-7 was significantly decreased on NK cells from HCV-infected and HBV-infected patients and, conversely, serum Siglec-7 was significantly increased in these patients compared with controls. The frequency of Siglec-7pos NK cells was significantly higher at baseline in sustained virological responders to pegylated interferon-α/ribavirin treatment than in non-responders. Activating receptor expression was significantly higher in Siglec-7pos NK cells and was associated with increased degranulation and cytokine secretion compared with Siglec-7<sup>neg</sup> cells. In chronic HCV infection, there was an inverse correlation between Siglec-7 expression and serum aminotransferases, γ-glutamyl transpeptidase, liver stiffness, aspartate aminotransferase to platelet ratio index and fibrosis-4 scores, and a positive correlation between serum Siglec-7 and the same clinical parameters, including histological staging. <h3>Conclusions</h3> These findings identify Siglec-7<sup>neg</sup> NK cells as a dysfunctional subpopulation associated with severe liver disease in chronic HCV infection.
Predictors of objective cough frequency in pulmonary sarcoidosis
Authors: Aish Sinha, Kai K. Lee, Gerrard F. Rafferty, Nadia Yousaf, Ian D. Pavord, James Galloway, Surinder S. Birring
Journal: European Respiratory Journal (2016)

Cough is a common symptom of pulmonary sarcoidosis. This study aimed to quantify cough frequency, and investigate its relationship with cough reflex sensitivity, pulmonary function and health status. 32 patients with pulmonary sarcoidosis were compared with 40 healthy controls. Cough reflex sensitivity to capsaicin, objective 24-h cough counts, cough-specific health status, cough severity and cough triggers were measured. The predictors of cough frequency in sarcoidosis were determined in a multivariate analysis. Objective cough frequency was significantly raised in patients with sarcoidosis compared with healthy controls (p&lt;0.001) and patients with cough had an impaired health status. Patients with pulmonary sarcoidosis had a heightened cough reflex sensitivity compared with healthy controls (p&lt;0.001). Only cough reflex sensitivity was significantly associated with objective cough frequency in multivariate analysis, explaining 42% of the variance (p&lt;0.001). There was no association between cough frequency, lung function, number of organs involved, chest radiograph stage or serum angiotensin-converting enzyme levels. Cough is a common and significant symptom in patients with sarcoidosis. Ambulatory objective cough monitoring provides novel insights into the determinants of cough in sarcoidosis, suggesting that cough reflex sensitivity may be more important than lung function and other measures of disease severity, and this should be investigated further.
Growth Kinetics of Mammary Tumor 13762 in Rats Previously Cured by Chemotherapy&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Paul G. Braunschweiger, Lewis M. Schiffer
Journal: JNCI Journal of the National Cancer Institute (1980)

We studied the growth capabilities of mammary tumor 13762 transplanted into inbred F344 rats previously cured of tumors by cell kinetically based sequential chemotherapy. Of the 18 challenge tumors, 4 were completely rejected, and nonrejected tumors grew at subnormal rates. The subnormal growth was specific for the cured rats because tumor growth in age- and therapy-matched non-tumor-bearing controls was normal. Cell kinetic studies with the use of in vitro techniques for the [3H]dThd labeling index, DNA synthesis time, and primer-dependent DNA polymerase labeling index (an in vitro estimate of growth fraction) indicated that the subnormal growth rates of the 13762 tumor in cured rats were due to subnormal tumor cell production. Cell loss rates were similar in tumors growing in cured rats and in size-matched tumors growing in normal controls. The results are consistent with the possibility that the subnormal growth of 13762 challenge tumors in chemotherapeutically cured F344 rats was mediated by immune factors.
GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility
Authors: Matthew C. Judson, Michael L. Wallace, Michael S. Sidorov, Alain C. Burette, Bin Gu, Geeske M. van Woerden, Ian F. King, Ji Eun Han, Mark J. Zylka, Ype Elgersma, Richard J. Weinberg, Benjamin D. Philpot
Journal: Neuron (2016)
Reactions to Dinitrochlorobenzene in Patients With Neuroblastoma and Survival 1 2
Authors: Lawrence Helson
Journal: JNCI Journal of the National Cancer Institute (1976)

To determine the relationship of cell-mediated immunity (CMI) to survival, I studied 67 children with the histologically confirmed diagnosis of neuroblastoma. CMI was measured by testing the ability of patients to develop sensitization to dinitrochlorobenzene (DNCB) and to respond to challenge. Reactions at the challenge sites were considered positive only when induration and swelling were present. Ninety percent of the patients with localized neuroblastoma and 27% of those with disseminated neuroblastoma were DNCB reactive. This suggested that patients with DNCB-positive reactions have a better chance of survival than those who are DNCB negative. Some patients with disseminated disease were evaluated in longitudinal studies, and alterations in reactivity did occur with changes in disease status and/or chemotherapy. The suggestion was made that this test systme is potentially useful in estimating survival in children with neuroblastoma.
Reduced cytotoxicity and enhanced bioactivity of cationic antimicrobial peptides liposomes in cell cultures and 3D epidermis model against HSV
Authors: Sapir Ron-Doitch, Beate Sawodny, Andreas Kühbacher, Mirjam M. Nordling David, Ayan Samanta, Jaywant Phopase, Anke Burger-Kentischer, May Griffith, Gershon Golomb, Steffen Rupp
Journal: Journal of Controlled Release (2016)
Three-drug combination of cisplatin, dacarbazine, and tamoxifen in metastatic malignant melanoma.
Authors: E Chmielowska, P Potemski, A Pluzańska
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.8.2146 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7636562 Three-drug combination of cisplatin, dacarbazine, and tamoxifen in metastatic malignant melanoma. E ChmielowskaxE ChmielowskaSearch for articles by this author , P PotemskixP PotemskiSearch for articles by this author , A PluzańskaxA PluzańskaSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.8.2146 PDF "Three-drug combination of cisplatin, dacarbazine, and tamoxifen in metastatic malignant melanoma.." Journal of Clinical Oncology, 13(8), pp. 2146–2147© 1995 by American Society of Clinical Oncology
Joining Together to Improve Outcomes: Integrating Specialty Palliative Care Into the Care of Patients With Cancer
Authors: Maxwell T. Vergo, Amelia M. Cullinan
Journal: Journal of the National Comprehensive Cancer Network (2013)

This article addresses the misconception that patients with cancer should undergo a definitive "transition" to palliative care at some point in their trajectory, and instead proposes that a gradual shift should occur from primary palliative care provided by the oncologist to specialty palliative care when the need exists. The goal is to help practitioners identify which patients are in need of specialty palliative care, suggest when oncologists should consider making a referral, and offer a model for sharing the responsibilities of care once palliative care clinicians become involved. This model enhances the patient and family experience through improving symptom control and quality of life, and may even prolong survival. It also minimizes patients' perception of abandonment at the end of life, while reducing the risk of physician burnout in practicing oncologists. Lastly, the misconceptions of oncologists are addressed regarding how patients and families will accept the idea of a palliative care consultation, and suggestions are offered for responding to patient and/or family resistance to referral when it arises.
Anterior pituitary, adrenal, and gonadal hormones during cocaine withdrawal
Authors: J H Mendelson, S K Teoh, U Lange, N K Mello, R Weiss, A Skupny, J Ellingboe
Journal: American Journal of Psychiatry (1988)

Plasma luteinizing hormone (LH), prolactin, testosterone, and cortisol levels were determined in 16 patients after hospital admission for cocaine abuse, during the course of 4 weeks of hospitalization, and before discharge. Hyperprolactinemia was found at admission (mean +/- SD, 27.5 +/- 10.2 ng/ml) and persisted until discharge (mean +/- SD, 28.7 +/- 10.8 ng/ml). Plasma LH, testosterone, and cortisol levels were within normal limits. These findings suggest that persistent elevation of plasma prolactin levels after cocaine withdrawal may reflect a chronic cocaine-induced derangement in neural dopaminergic regulatory systems.
Advocating for Older Adults With Cancer: Merging Medicine and Law
Authors: Arti Hurria, Laura A. Levit
Journal: Journal of the National Comprehensive Cancer Network (2015)

Dr. Arti Hurria is a geriatrician and oncologist. She completed the Harvard Geriatric Fellowship Program, followed by a hematology-oncology fellowship at Memorial Sloan Kettering Cancer Center (MSKCC). Subsequently, she joined the faculty at MSKCC, where she served as co-Principal Investigator on an institutional NIH P20 grant “Development of an Aging and Cancer Center.” In 2006, Dr. Hurria joined City of Hope as Director of the Cancer and Aging Research Program and an Associate Professor, where she is actively involved in both patient care and research. She has served as the President for the International Society of Geriatric Oncology (2012–2014), and is currently serving as Chair of the NCCN Senior Adult Oncology Panel, co-Vice Chair of the Alliance Cancer in the Elderly Committee, and Editor-in Chief of the Journal of Geriatric Oncology. Dr. Hurria is also founder of the Cancer and Aging Research Group, a coalition that conducts multi-center geriatric oncology research studies and mentors junior faculty in geriatric oncology. She holds two R01 grants aimed at improving the care of older adults with cancer. In 2013, she received the ASCO B.J. Kennedy Award for Scientific Excellence in Geriatric Oncology.
Survivorship: Healthy Lifestyles, Version 2.2014
Authors: Crystal S. Denlinger, Jennifer A. Ligibel, Madhuri Are, K. Scott Baker, Wendy Demark-Wahnefried, Don Dizon, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Grace H. Ku, Elizabeth Kvale, Terry S. Langbaum, Kristin Leonardi-Warren, Mary S. McCabe, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Javid J. Moslehi, Tracey O’Connor, Linda Overholser, Electra D. Paskett, Jeffrey Peppercorn, Muhammad Raza, M. Alma Rodriguez, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole R. McMillian, Deborah A. Freedman-Cass
Journal: Journal of the National Comprehensive Cancer Network (2014)

Healthy lifestyle habits have been associated with improved health outcomes and quality of life and, for some cancers, a reduced risk of recurrence and death. The NCCN Guidelines for Survivorship therefore recommend that cancer survivors be encouraged to achieve and maintain a healthy lifestyle, with attention to weight management, physical activity, and dietary habits. This section of the NCCN Guidelines focuses on recommendations regarding physical activity in survivors, including assessment for the risk of exercise-induced adverse events, exercise prescriptions, guidance for resistance training, and considerations for specific populations (eg, survivors with lymphedema, ostomies, peripheral neuropathy). In addition, strategies to encourage health behavioral change in survivors are discussed.
Abstract 17638: Systemic Cardiovascular Effects of Intravenous Urocortin 2 and Urocortin 3 in Patients with Heart Failure and Healthy Volunteers
Authors: Colin G Stirrat, Sowmya Venkatasubramanian, Tania Pawade, Andrew Mitchell, Anoop Shah, Amanda Hunter, Ninan N Lang, David E Newby
Journal: Circulation (2014)

Introduction: Urocortin 2 (UCN 2) and urocortin 3 (UCN 3) are endogenous peptide hormones with an emerging role in the pathophysiology and treatment of heart failure. For the first time, we examined the systemic cardiovascular effects of both UCN 2 and UCN 3 in healthy volunteers and patients with heart failure. Methods: Seven healthy volunteers (Group A) and nine patients with stable chronic heart failure (Group B, New York Heart Association class II and III, left ventricular ejection fraction &lt;35%) on optimal medical therapy underwent non-invasive oscillometric sphygmomanometry and impedance cardiography during incremental intravenous infusions of sodium nitroprusside (0.15/0.5/1.5 μg/kg/min), UCN 2 (0.16/0.48/1.6 μg/min), UCN 3 (5/15/50 μg/min) and saline placebo in a randomised double blind two-way cross over study. Results: Other than diastolic blood pressure (78 vs 72 mmHg for Group A and B respectively, p&lt;0.05), haemodynamic variables were similar at baseline of each infusion and were unchanged by saline placebo infusion (p&gt;0.05 for all). SNP, UCN2 and UCN 3 infusions increased heart rate and cardiac index, and reduced systolic and diastolic blood pressure and peripheral vascular resistance index (PVRI) in both healthy volunteers and patients with heart failure (p&lt;0.05 for all; see Figure 1). There were no significant differences in the changes in cardiac index or PVRI between healthy volunteers and patients with heart failure during either UCN 2 or UCN 3 infusions (p&gt;0.05). Conclusion: Intravenous UCN 2 and especially UCN 3 increase cardiac output and reduce peripheral vascular resistance. This favourable haemodynamic profile suggests that UCN 2 and UCN 3 hold exciting therapeutic potential for the treatment of acute heart failure.
Effects of Endocrinologic Conditions Associated With Acute Versus Chronic Lactation on the Incidence of Mammary Carcinomas in Irradiated Rats: Brief Communication2
Authors: Michael N. Gould, Kelly H. Clifton, John Crowley
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Effects of Endocrinologic Conditions Associated With Acute Versus Chronic Lactation on the Incidence of Mammary Carcinomas in Irradiated Rats: Brief Communication Get access Michael N. Gould, Michael N. Gould Search for other works by this author on: Oxford Academic PubMed Google Scholar Kelly H. Clifton, Kelly H. Clifton 5 5Address reprint requests to Dr. K. H. Clifton. Search for other works by this author on: Oxford Academic PubMed Google Scholar John Crowley John Crowley Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 60, Issue 2, February 1978, Pages 469–471, https://doi.org/10.1093/jnci/60.2.469 Published: 01 February 1978 Article history Received: 20 June 1977 Accepted: 22 September 1977 Published: 01 February 1978
MicroRNA signatures in Genetic Subtypes of T-Cell Acute Lymphoblastic Leukemia.
Authors: Pieter Van Vlierberghe, Bruce Poppe, Nadine Van Roy, Tom Taghon, Jean Plum, Barbara Cauwelier, Dominik L.D. Selleslag, Pierre Heimann, Peter Vandenberghe, Nicole Dastugue, Eric Delabesse, Carine Gervais, Marie-Jose Gregoire, Marie-Joelle Mozzicconacci, Christine Lefebvre, Jules P.P. Meijerink, Jessica Buijs-Gladdines, Barbara De Moerloose, Yves Benoit, Frank Speleman
Journal: Blood (2008)
Substance abuse attitude changes in medical students
Authors: J N Chappel, R D Jordan, B J Treadway, P R Miller
Journal: American Journal of Psychiatry (1977)

The authors describe a course in substance abuse given to sophomore medical students with the intention of positively influencing their attitudes toward substance-abusing patients and their treatment. Clinical problem solving and small group discussion were emphasized in addition to field trips. By pretest and posttest measures, significant positive changes were obtained in student attitudes: they reported feeling less upset when they encountered alcoholics, "hard" drug abusers, "soft" drug abusers, compulsive smokers, and obese overeaters as well as having a more positive view of the physician's role in the treatment of substance dependence. Personal experience with alcohol and other drugs was shown to have an influence on attitude changes.
Mammary Carcinoma Arising in Mice Undergoing a Chronic Graft-Versus-Host Reaction&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: J G Gartner, T A Seemayer, W S Lapp
Journal: JNCI Journal of the National Cancer Institute (1984)

A graft-versus-host reaction (GVHR) was induced in 30 (CBA X A)F1 mice by the iv injection of 50 X 10(6) parental strain A lymphoid cells. Solid tumors emerged in 5 of 10 experimental animals that survived beyond 14 months after the GVHR was initiated. The neoplasms were judged to be mammary carcinomas by light and electron microscopic examinations. C-type RNA viral structures were observed in some tumor cells. The neoplasms were successfully transplanted into syngeneic animals by either sc or ip injections of tumor cell suspensions. Tumor transfer to syngeneic mice was not possible if only spleen cells from tumor-bearing animals were transferred. No tumors developed in an age-matched control group that received no treatment.
Implementing tuberculosis entry screening for asylum seekers: the Groningen experience
Authors: Onno W. Akkerman, Wiel C.M. de Lange, Elisabeth H. Schölvinck, Bert Wolters, Yvonne Aartsma, Tjip S. van der Werf, Rob van Hest
Journal: European Respiratory Journal (2016)

For 3 years, Europe has faced an increasing refugee crisis in which hundreds of thousands of displaced persons are risking their lives to seek a safer and better future in the European Union (EU). Many of these migrants originate from highly tuberculosis (TB)-endemic countries. Furthermore, their travel conditions are often poor, allowing potential transmission of infectious diseases, including TB. The Netherlands have observed an increased influx of asylum seekers since 2012 too, with fluctuating numbers every month, and a sharp increase in the summer of 2015, putting constraints on the process of registration, identification, application and accommodation, including mandatory radiographic screening for intrathoracic TB. We describe the impact of such migration on the Public Health TB Clinic of Groningen (responsible for nearly all TB entry screening for asylum seekers in the Netherlands), and our flexible and efficient practice model for daily radiographic TB screening. We report the yield of this intervention over the last 4 years, and reflect on issues concerning entry screening. The Dutch practice model for radiographic TB screening of asylum seekers has proved feasible <http://ow.ly/Z1QTP>
Errors by locums
Authors: P. F Jones
Journal: BMJ (1996)

on which over the counter drug they had recom- mended and the reason for the recommendation.Table 1 gives the number and proportion of consultations at which information on prior use of an over the counter drug was elicited and at which a prescription was issued or an over the counter drug was recommended, or both.Over the counter drugs were recommended during 444 consultations, but the actual drug was stated in only 413.The six general practitioners varied considerably in their rates of recommending over the counter drugs (from 2.3% to 37.5%) and issuing prescriptions (from 30.6% to 78.2%).Recommending an over the counter drug seems to be a management option that is used in addition to, rather than instead of, issuing a prescription.Most recommendations (305/413) were for simple analgesics, especially paracetamol preparations (184/413).Medicines that have changed since 1990 from being available only on prescription to being available in pharmacies hardly featured (8/413).The main reason doctors gave for recommending over the counter drugs was that they were cheaper for some patients.Increasing patient autonomy or capacity for self care and potential savings in the practice's prescribing budget did not emerge as major reasons for recommending over the counter drugs.