tbuckley/cabot-search huggingface dataset:
Near-infrared light-responsive inorganic nanomaterials for photothermal therapy
Authors: Zhihong Bao, Xuerong Liu, Yangdi Liu, Hongzhuo Liu, Kun Zhao
Journal: Asian Journal of Pharmaceutical Sciences (2016)

Novel nanomaterials and advanced nanotechnologies prompt the fast development of new protocols for biomedical application. The unique light-to-heat conversion property of nanoscale materials can be utilized to produce novel and effective therapeutics for cancer treatment. In particular, near-infrared (NIR) photothermal therapy (PTT) has gained popularity and very quickly developed in recent years due to minimally invasive treatments for patients. This review summarizes the current state-of-the-art in the development of inorganic nanocomposites for photothermal cancer therapy. The current states of the design, synthesis, the cellular uptake behavior, the cellular cytotoxicity and both in vivo and in vitro nanoparticle assisted photothermal treatments of inorganic photothermal therapy agents (PTA) are described. Finally, the perspective and challenges of PTT development are presented and some proposals are suggested for its further development and exploration. This summary should provide improved understanding of cancer treatment with photothermal nanomaterials and push nanoscience and nanotechnology one step at a time toward clinical applications.
Auricularia auricular polysaccharide-low molecular weight chitosan polyelectrolyte complex nanoparticles: Preparation and characterization
Authors: Wei Xiong, Qiantao Zhang, Fei Yin, Shihui Yu, Tiantian Ye, Weisan Pan, Xinggang Yang
Journal: Asian Journal of Pharmaceutical Sciences (2016)

Novel polyelectrolyte complex nanoparticles (AAP/LCS NPs) were prepared in this study and these were produced by mixing negatively charged auricularia auricular polysaccharide (AAP) with positively charged low molecular weight chitosan (LCS) in an aqueous medium. The AAP was extracted and purified from auricularia auricular, and then characterized by micrOTOF-Q mass spectrometry, UV/Vis spectrophotometry, moisture analyzer and SEM. The yield, moisture, and total sugar content of the AAP were 4.5%, 6.2% and 90.12% (w/w), respectively. The AAP sample was water-soluble and exhibited white flocculence. The characteristics of AAP/LCS NPs, such as the particle size, zeta potential, morphology, FT-IR spectra, DSC were investigated. The results obtained revealed that the AAP/LCS NPs had a spherical shape with a diameter of 223 nm and a smooth surface, and the results of the FT-IR spectra and DSC investigations indicated that there was an electrostatic interaction between the two polyelectrolyte polymers. Bovine serum albumin (BSA, pI = 4.8) and bovine hemoglobin (BHb, pI = 6.8) were used as model drugs to investigate the loading and release features of the AAP/LCS NPs. The results obtained showed that the AAP/LCS NPs had a higher entrapment efficiency (92.6%) for BHb than for BSA (81.5%). The cumulative release of BSA and BHb from AAP/LCS NPs after 24 h in vitro was 95.4% and 91.9%, respectively. The in vitro release demonstrated that AAP/LCS NPs provided a sustained release matrix suitable for the delivery of protein drugs. These studies demonstrate that AAP/LCS NPs have a very promising potential as a delivery system for protein drugs.
A novel MHC- dextramer assay to identify melanoma antigen-specific CD8+ T cells from solid tumor disaggregates and matched peripheral blood
Authors: Shen-wu Wang, Katherine Paweletz, Michael Chastain, Robert Loberg, Gloria Juan
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Cytotoxic CD8+ T lymphocytes (CTL) mediate target cell killing of tumor cells. New technological advances in multi-parameter flow cytometry have enabled the detection and enumeration of antigen-specific CD8+ T cells (MHC-class I dextramer staining) in peripheral blood. A new
The need for quality assurance of health apps
Authors: Brian McMillan, Eamonn Hickey, Caroline Mitchell, Mahendra Patel
Journal: BMJ (2015)

With patients and healthcare professionals increasingly using health apps, Armstrong's article is timely. 1 At the Academic Unit of Primary Medical Care in Sheffield we examined quality assurance for health behaviour change apps by adapting the 2014 NICE behaviour change guidance. 2 We identified nine areas that are important to consider when examining the quality of such apps-purpose, planning and development, usability, assessment and tailoring, behaviour change technique, maintenance and relapse, evaluation, documentation, and data protection. 3 Behaviour change apps from the now closed NHS apps library were clear in terms of purpose, but few showed evidence of thorough planning and development or of addressing how behavioural changes could be maintained.There was little focus on usability, and evidence for the evaluation of app efficacy was poor.Documentation varied, and only a minority showed evidence of initial assessment and tailoring.Although the quality of apps varies greatly, the RCP's advice to avoid apps that lack a CE mark seems extreme.Until a clear quality assurance scheme is widely adopted, it seems sensible to view apps with the same degree of healthy scepticism that we afford other online sources of information.We look forward to a time when less vigilance is needed and there is a process in place to reassure healthcare professionals that the apps that they are using or recommending are reliable and trustworthy.It will be interesting to see how well the proposed National Information Board four step assessment process deals with these problems.
Targeting B cell malignancies through human B cell receptor specific CD4 T cells
Authors: Jinsheng Weng, Flavio Egidio Baio, Kelsey Moriarty, Hiroki Torikai, Hua Wang, Zhiqiang Liu, Sourindra Maiti, Dongho Gwak, Michael Popescu, Soung-chul Cha, Sattva S Neelapu, Larry Kwak
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts The B cell receptor (BCR) expressed by a clonal B cell tumor is a tumor specific antigen (idiotype). However, the T cell epitopes within human BCRs which stimulate protective immunity still lack detailed characterization. In this study, we identified 17 potential CD4 T cell
Infectious complications in children with acute myeloid leukemia: decreased mortality in multicenter trial AML-BFM 2004
Authors: K Bochennek, A Hassler, C Perner, J Gilfert, S Schöning, T Klingebiel, D Reinhardt, U Creutzig, T Lehrnbecher
Journal: Blood Cancer Journal (2016)

Abstract Infections are an important cause for morbidity and mortality in pediatric acute myeloid leukemia (AML). We therefore characterized infectious complications in children treated according to the trial AML-BFM 2004. Patients with Down syndrome were excluded from the analysis. Data were gathered from the medical records in the hospital where the patients were treated. A total of 405 patients (203 girls; median age 8.4 years) experienced 1326 infections. Fever without identifiable source occurred in 56.1% of the patients and clinically and microbiologically documented infections in 17.5% and 32.4% of the patients, respectively. In all, 240 Gram-positive (112 viridans group streptococci) and 90 Gram-negative isolates were recovered from the bloodstream. Invasive fungal infection was diagnosed in 3% of the patients. Three children each died of Gram-negative bacteremia and invasive aspergillosis, respectively. As compared with the results of AML-BFM 93 with lower dose intensity, infection-related morbidity was slightly higher in AML-BFM 2004 (3.3. versus 2.8 infections per patient), whereas infection-related mortality significantly decreased (1.5% versus 5.4%; P =0.003). Specific anti-infective recommendations included in the treatment protocol, regular training courses for pediatric hematologists and increasing experience may be the reason for reduced infection-related mortality in children with AML. Further studies are needed to decrease infection-related morbidity.
Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I–III Non–Small-Cell Lung Cancer
Authors: Dylan M. Glubb, Laia Paré-Brunet, Eloisa Jantus-Lewintre, Chen Jiang, Daniel Crona, Amy S. Etheridge, Osman Mirza, Wei Zhang, Eric L. Seiser, Witold Rzyman, Jacek Jassem, Todd Auman, Fred R. Hirsch, Kouros Owzar, Carlos Camps, Rafal Dziadziuszko, Federico Innocenti
Journal: Journal of Thoracic Oncology (2015)
P0629 : First detection of genotype 3 and 4 hepatitis E virus (HEV) RNA among the general population in cambodia: Full-length sequence of HEV isolate, prevalence and incidence of HEV infection were clarified based on the Sero-epidemiological study
Authors: H. Yamada, K. Takahashi, O. Lim, J. Matsuo, T. Kaishima, T. Fujii, K. Katayama, S. Svay, J. Tanaka
Journal: Journal of Hepatology (2015)
Pulse Pressure and Risk for Cardiovascular Events in Patients With Atherothrombosis
Authors: Senthil Selvaraj, Ph. Gabriel Steg, Yedid Elbez, Emmanuel Sorbets, Laurent J. Feldman, Kim A. Eagle, E. Magnus Ohman, Jacques Blacher, Deepak L. Bhatt
Journal: Journal of the American College of Cardiology (2016)
2015 ACR/ACC/AHA/AATS/ACEP/ASNC/NASCI/SAEM/SCCT/SCMR/SCPC/SNMMI/STR/STS Appropriate Utilization of Cardiovascular Imaging in Emergency Department Patients With Chest Pain
Authors: Frank J. Rybicki, James E. Udelson, W. Frank Peacock, Samuel Z. Goldhaber, Eric M. Isselbacher, Ella Kazerooni, Michael C. Kontos, Harold Litt, Pamela K. Woodard
Journal: Journal of the American College of Cardiology (2016)
Fluorescence excitation photography of epidermal cellular proliferation
Authors: E. Gutierrez-Herrera, A.E. Ortiz, A. Doukas, W. Franco
Journal: British Journal of Dermatology (2016)

Fluorescence excitation provides the ability to interrogate innate molecules whose radiation emission correlates with specific functional states of tissue.The present study demonstrates the effectiveness of a novel ultraviolet (UV) fluorescence excitation photography system in its ability to image rapidly proliferating epidermal skin lesions by capturing endogenous fluorescence emissions attributed to tryptophan.A clinical prototype UV fluorescence excitation photography system was used to acquire images of endogenous fluorescence ascribed to tryptophan.Twelve human subjects and 11 ex vivo samples with various skin lesions consistently exhibited increased endogenous fluorescence at 340-nm wavelength upon excitation at 295 nm in rapid epidermal proliferations, including psoriasis, actinic keratoses and basal cell carcinoma, compared with surrounding normal skin. In contrast, nonproliferating lesions showed decreased fluorescence.This simple but robust point-and-shoot imaging system may offer a clinically useful, noncontact, noninvasive device for the diagnosis and detection of skin disease. As opposed to structural imaging modalities, fluorescence excitation imaging at 295/340-nm wavelengths offers high-sensitivity, wide-field functional imaging of cellular proliferation without the need for externally applied dyes or lengthy image processing. Furthermore, the image is instantly available and does not require interpretation or reconstruction.
The clinical pathogensis significance associated with mutation of APC MCR in colorectal neoplasms
Authors: R. Lai, L. Feng, L. Liu, L. Xie, X. Wu, S. Zhang, X. Tang, J. Geng, T. Chen
Journal: Journal of Clinical Oncology (2009)

e15119 Background: To explore the clinical pathogensis evalution of codon 1493,1367 and 1328 mutations in MCR (mutation cluster region) of exon 15 of APC (Adenomatous polyposis coli) gene in cases of colorectal neoplasm and the family history. Methods: The specimens from 21 colorectal adenoma specimens groups,16 colorectal carcinoma groups, 20 healthy germline groups with positive familial history and 8 healthy germline groups without familial history. MCR of APC gene were extracted and specificly amplified, then sequenced by sequencer, the codon mutations were analyzed between the 4 groups and various genotypes tested with Chi-square. Results: The codon mutations were three variations: 1493(ACG &gt; ACA), 63/69(91.3%); 1367(CAG &gt; TAG), 1/69(1.4%) and 1328(CAG&gt;TAG), 5/69(7.2%). The allele mutations were checked out four genotypes such as 4478(G→A), 41/69(59.4%); 4478(G/A), 22/69(31.9%); 4096(C/T), 1/69 (1.4%) and 3979(C/T), 5/69(7.2%); but the significant groups status (P&lt;0.05) were shown between the adenoma and nonfamily history group on the analysis of 4478(G→A) and (G/A), also the significant differences were tested between the with and without family history on the analysis of 4478(G→A). The significant differences (P&lt;0.05) in pathogensis mutant phenotypes were involved between 4478(G→A) with 4478(G/A), 4096(C/T) and 3979(C/T), respectively; also showed between 4478(G/A) with 4096(C/T) and 3979(C/T); but not between 4096(C/T) and 3979(C/T) (P&gt;0.05). Conclusions: In our data, the highest mutant frequency 4478(G→A) of 1493(ACG&gt;ACA) presented to the significant phenotype of positive history and adenoma, but 4478 (G/A) were associated with colorectal adenocancer, which was discovered in the different effect to candidators despite the same synonymous mutation. In researches, APC MCR codon 1367 and 1328 genotyping were significantly presented in the colorectal cancergenetic phenotypes in somatic cells only. No significant financial relationships to disclose.
PD2-1-1: Efficacy of BI 2536, a potent and selective inhibitor of the mitotic kinase Plk1, in models of human non-small cell lung carcinoma
Authors: Anke Baum, Pilar Garin-Chesa, Ulrich Gürtler, Gerd Munzert, Dorothea I. Rudolph
Journal: Journal of Thoracic Oncology (2007)
Spray drying of fenofibrate loaded nanostructured lipid carriers
Authors: Dengning Xia, Neha Shrestha, Jacco van de Streek, Huiling Mu, Mingshi Yang
Journal: Asian Journal of Pharmaceutical Sciences (2016)

The conversion of aqueous dispersion of nanostructured lipid carriers (NLCs) into dry powder by spray drying could be a useful approach to render NLCs with better physical chemical stability than the aqueous dispersion. In this study, aqueous NLC dispersion containing fenofibrate was converted into dry, easily reconstitutable powder using spray drying. A central composite face centered design (CCFD) was used to investigate the influence of the ratio of lipid to protectant (mannitol and trehalose) and crystallinity of spray-dried powder on the particle size, yield and residual moisture content of the dried powder. A linear relationship (R2 = 0.9915) was established between the crystalline content of the spray-dried powders against the ratio of mannitol to trehalose from 3:7 to 10:0 (w/w). Spray drying of NLC aqueous dispersion using a mannitol and trehalose mixture resulted in an increase in particle size of the NLCs after reconstitution in water as compared to that in the initial aqueous dispersion. The decrease in crystallinity of the dry powder by reducing the ratio of mannitol to trehalose could improve the reconstitution of the NLCs in water. However the yield and residual moisture content of dry powder decreased with an increase in the ratio of mannitol to trehalose. Lipid nanoparticles were able to retain the drug incorporation and the prolonged drug release profile after spray drying. The experimental model was robust, and suggested that spray drying is a viable technique for the conversion of NLCs into dry powder.
P0152 : The effect of irsogladine maleate for Portal Hypertensive Gastropathy (PHG)
Authors: K. Yokoyama, M. Irie, A. Anan, S. Fukuda, N. Thuchiya, A. Fukunaga, K. Takata, T. Tanaka, T. Hanano, G. Hirano, D. Morihara, Y. Takeyama, S. Shakado, T. Sohda, S. Sakisaka
Journal: Journal of Hepatology (2015)
Retroperitoneal Metastasis from Lung Adenocarcinoma Mimics Retroperitoneal Fibrosis
Authors: Akihiro Nishiyama, Hiroshige Yoshioka, Satoshi Ikeo, Mitsunori Morita, Naoyuki Sone, Satoshi Ikeda, Toshihide Yokoyama, Tadashi Ishida
Journal: Journal of Thoracic Oncology (2015)
1-year outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease: a patient-level, pooled meta-analysis
Authors: Gregg W Stone, Runlin Gao, Takeshi Kimura, Dean J Kereiakes, Stephen G Ellis, Yoshinobu Onuma, Wai-Fung Cheong, Jennifer Jones-McMeans, Xiaolu Su, Zhen Zhang, Patrick W Serruys
Journal: The Lancet (2016)
Prenatal maternal psychological stress and childhood asthma and wheezing: a meta-analysis
Authors: Kim F.E. van de Loo, Marleen M.H.J. van Gelder, Jolt Roukema, Nel Roeleveld, Peter J.F.M. Merkus, Christianne M. Verhaak
Journal: European Respiratory Journal (2015)

The aim of this study was to systematically review and meta-analyse observational studies on prenatal maternal psychological stress and the subsequent development of asthma and wheezing in early childhood.All available published literature from 1960 until November 2013 was systematically searched through electronic databases (PubMed, Embase, PsycInfo and Web of Science). All observational studies assessing associations between any form of prenatal maternal psychological stress and respiratory morbidity in the child were included. Data extraction, quality assessment and meta-analyses were performed.The overall meta-analysis included 10 studies and showed that the prevalence of wheezing, asthma and other respiratory symptoms is higher in children of mothers who were exposed to or experienced some form of psychological stress during pregnancy than in mothers who did not (pooled OR 1.56 (95% CI 1.36-1.80)). Comparable results were observed in subgroup analyses of stress exposure, perceived stress, asthma and wheezing.This study demonstrates that prenatal maternal psychological stress is associated with respiratory morbidity, including asthma and wheezing in the child. Future studies examining the early origins of asthma and wheezing need to account for the impact of prenatal maternal stress.
Abstract 3372: Post-operative Assessment of Mitral Valve Repair with 3D Echocardiography is Superior to 2D Assessment
Authors: Stephen P Hoole, Tze V Liew, James Boyd, Francis C Wells, Rosemary A Rusk
Journal: Circulation (2006)

Introduction: Post-operative imaging of mitral valve repair is vital to document operative success. 2D echocardiography is limited in the detection of all mitral segments. We hypothesized that 3D e...
Genomic dissection of Australian Bordetella pertussis isolates from the 2008–2012 epidemic
Authors: Azadeh Safarchi, Sophie Octavia, Sunny Z. Wu, Sandeep Kaur, Vitali Sintchenko, Gwendolyn L. Gilbert, Nicholas Wood, Peter McIntyre, Helen Marshall, Anthony D. Keil, Ruiting Lan
Journal: Journal of Infection (2016)
Efficacy of Low-Dose Chlorthalidone and Hydrochlorothiazide as Assessed by 24-h Ambulatory Blood Pressure Monitoring
Authors: Anil K. Pareek, Franz H. Messerli, Nitin B. Chandurkar, Shruti K. Dharmadhikari, Anil V. Godbole, Prasita P. Kshirsagar, Manish A. Agarwal, Kamal H. Sharma, Shyam L. Mathur, Mukund M. Kumbla
Journal: Journal of the American College of Cardiology (2016)
Latest Evidence on the Use of Phosphodiesterase Type 5 Inhibitors for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
Authors: Mauro Gacci, Karl-Erik Andersson, Christopher Chapple, Mario Maggi, Vincenzo Mirone, Matthias Oelke, Hartmut Porst, Claus Roehrborn, Christian Stief, François Giuliano
Journal: European Urology (2016)
Prognostic Factors of Survival after Recurrence in Patients with Resected Lung Adenocarcinoma
Authors: Jung-Jyh Hung, Yi-Chen Yeh, Wen-Juei Jeng, Hong-Che Chien, Yu-Chung Wu, Teh-Ying Chou, Wen-Hu Hsu
Journal: Journal of Thoracic Oncology (2015)
WITHDRAWN: Differences in affinity of hypotaurine towards Slc6a GABA/taurine transporters
Authors: Yuko Yoshida, Tomohiro Nishimura, Kei Higuchi, Masatoshi Tomi, Emi Nakashima
Journal: Asian Journal of Pharmaceutical Sciences (2015)

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
New Treatments for Advanced Hodgkin’s Disease: An Uphill Fight Beginning Close to the Top
Authors: George P. Canellos
Journal: Journal of Clinical Oncology (2002)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.3.607 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11821436 New Treatments for Advanced Hodgkin's Disease: An Uphill Fight Beginning Close to the Top George P. CanellosxGeorge P. CanellosSearch for articles by this author Show More Dana-Farber Cancer Institute, Boston, MA https://doi.org/10.1200/JCO.2002.20.3.607 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study
Authors: Tanya Keenan, Wei Zhao, Asif Rasheed, Weang K. Ho, Rainer Malik, Janine F. Felix, Robin Young, Nabi Shah, Maria Samuel, Nasir Sheikh, Megan L. Mucksavage, Omar Shah, Jin Li, Michael Morley, Annika Laser, Nadeem Hayat Mallick, Khan Shah Zaman, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Faisal Ahmed, Bashir Hanif, Muhammad Shakir Lakhani, Muhammad Fahim, Madiha Ishaq, Naresh Kumar Shardha, Naveeduddin Ahmed, Khalid Mahmood, Waseem Iqbal, Saba Akhtar, Rabia Raheel, Christopher J. O'Donnell, Christian Hengstenberg, Winifred März, Sekar Kathiresan, Nilesh Samani, Anuj Goel, Jemma C. Hopewell, John Chambers, Yu-Ching Cheng, Pankaj Sharma, Qiong Yang, Jonathan Rosand, Giorgio B. Boncoraglio, Shahana Urooj Kazmi, Hakon Hakonarson, Anna Köttgen, Andreas Kalogeropoulos, Philippe Frossard, Ayeesha Kamal, Martin Dichgans, Thomas Cappola, Muredach P. Reilly, John Danesh, Daniel J. Rader, Benjamin F. Voight, Danish Saleheen
Journal: Journal of the American College of Cardiology (2016)
Tumor-derived alpha fetoprotein directly impacts human natural killer cell activity and viability
Authors: Lazar Vujanovic, Elizabeth Stahl, Angela Pardee, Simon Watkins, Gregory Gibson, Lisa H Butterfield
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Alpha-fetoprotein (AFP) is an oncofetal antigen produced by hepatocellular carcinomas (HCC). Previous studies demonstrated that tumor-derived AFP (tAFP) is a glycoprotein that has an immunosuppressive role on natural killer (NK), T, B, and dendritic (DC) cells which may play a
Interest of [ 18 F]fluorodeoxyglucose positron emission tomography/computed tomography for the diagnosis of relapse in patients with spinal infection: a prospective study
Authors: F.-A. Dauchy, A. Dutertre, S. Lawson-Ayayi, H. de Clermont-Gallerande, C. Fournier, P. Zanotti-Fregonara, H. Dutronc, J.-M. Vital, M. Dupon, P. Fernandez
Journal: Clinical Microbiology and Infection (2016)