tbuckley/cabot-search huggingface dataset:
Insertion of two overlapping new covered metal stents for closure of a complex biliary leak and description of a safe technique for their removal
Authors: C. Luigiano, F. Ferrara, C. Fabbri, M. Bassi, V. Cennamo, N. D’Imperio
Journal: Endoscopy (2011)

Recently, the use of partially or fully covered self-expandable metal stents (FCSEMSs) has been described for the treatment of complex bile leaks after laparoscopic or open cholecystectomy [1] [2].
Hemodilution Perfusions for Open-Heart Surgery
Authors: Richard A. DeWall, Richard C. Lillehei, Robert D. Sellers
Journal: New England Journal of Medicine (1962)

PERFUSION systems for open intracardiac surgery have become increasingly complicated. Compounding the difficulties are requirements for massive amounts of special blood — as much as 10.5 liters per patient.1 A refreshing change in this trend was brought about by the work of Zuhdi et al.,2 who emphasized the effectiveness of low-volume perfusion rates utilizing moderate hypothermia and priming of the pump oxygenator with a restricted amount of 5 per cent dextrose in water. In this way, they accomplished open intracardiac surgery without heparinized blood, using only 2 or 3 units of ordinary bank blood3 to replace thoracotomy losses. We have . . .
P64 Course and variation of the intercostal artery by computed tomography
Authors: N. M. Rahman, E. J. Helm, O. Talakoub, R. J. O. Davies, F. V. Gleeson
Journal: Thorax (2010)

<h3>Background</h3> The intercostal artery is thought to be shielded in the groove of the superior rib; however, the course and variability of the intercostal artery, and factors which may influence these, have not been described in vivo. Describing these variables in vivo has potentially important implications for avoiding complications during common pleural procedures. <h3>Methods</h3> Maximum intensity projection (MIP) reformats in the coronal plane were produced from CT pulmonary angiograms, to identify the posterolateral course of the contrast opacified intercostal artery. A novel semi-automated computer segmentation algorithm was used to identify and measure distances between the lower border of the superior rib, the upper border of the inferior rib and the position of the intercostal artery when exposed in the intercostal space, and manually verified by a radiologist. Position and variability of the artery were described and then analysed for association with clinical factors using a random effects regression model. <h3>Results</h3> 298 arteries were analysed from 48 patients (mean age 60 years). The mean lateral distance from the spine over which the artery was exposed within the intercostal space (‘unsafe artery length’) was 39 mm with wide variability (SD=10 mm, 10th to 90th centile 28 mm to 51 mm, Abstract P64 Figure 1A). At 3 cm lateral distance from the spine 16.6% of arteries were shielded by the superior rib, compared to 96.6% at 6 cm. Unsafe artery length was not associated with age, sex, rib space or side. Using regression modelling, variability of arterial position (as SD and coefficient of variation) was significantly associated with age (coeff 0.91, p&lt;0.001) and rib space number (coeff −2.60, p&lt;0.001) (Abstract P64 Figure 1B). Variability of arterial position was strongly negatively correlated with lateral distance from the spine (Pearson9s −0.77, p&lt;0.001). <h3>Conclusions</h3> The intercostal artery is exposed within the intercostal space in the first 6 cm lateral to the spine; variability of its vertical position is greater in older patients and more cephalad rib spaces. This implies that pleural interventions within 6 cm lateral to the spine should be conducted with caution and that the risk of intercostal artery laceration is potentially higher in older patients and more cephalad rib spaces.
F-18 FDG Uptake in Hemorrhoids in a Patient With Diffuse Large B-cell Lymphoma
Authors: Tanyaluck Thientunyakit, Sze Ting Lee, Sam Berlangieri
Journal: Clinical Nuclear Medicine (2011)

A 79-year-old man with diffuse large B-cell lymphoma was presented for assessment of metabolic response to chemotherapy. The baseline F-18 FDG PET showed extensive nodal, soft tissue, and bone metastases, which have completely resolved on the subsequent follow-up study, except for persistent perianal FDG activity. The perianal FDG activity was explained by inflammatory changes, secondary to hemorrhoids evident on the corresponding contrast-enhanced CT study. This exemplified the application of FDG PET/CT in detecting benign inflammatory disorders and the importance of correlation with CT to minimize misdiagnosis of residual malignancy.
Novel ERCP technique using a pushing catheter as a “mini-overtube” to remove a migrated metal stent from the bile duct
Authors: Carolina Olano, Klaus Mönkemüller
Journal: Endoscopy (2014)

The use of fully-covered self-expanding metal stents (FCSEMSs) for benign and malignant biliary diseases is well established [1]. Whereas migration out of the bile duct is not uncommon, inward migration is rare and much more difficult to manage [2]. We report on a new technique to remove an internally migrated FCSEMS.
Fluorine-18 Fluorodeoxyglucose Uptake in the Retractile Testis
Authors: H Fujii, S Yasuda, M Ide, W Takahashi, A Shohtsu, A Kubo
Journal: Clinical Nuclear Medicine (1999)

A 51-year-old man with a palpable mass in his right inguinal region had fluorine-18 fluorodeoxygluclose (F-18 FDG) whole-body positron emission tomography (PET) in our cancer screening program. FDG accumulated in the mass, suggesting a metabolically active lesion that was likely malignant. A pelvic MRI and a urologist's palpation revealed that his inguinal mass was a retractile testis. Because a retractile testis is a benign process with no need for interventional therapy, it would be considered a false-positive finding on the cancer screening program using F-18 FDG PET.
HOSPITAL PERFORMANCE FOR ACUTE MYOCARDIAL INFARCTION WITH THE NCDR ACTION REGISTRY-GWTG “ALL-OR-NONE COMPOSITE MEASURE”: MORE OPPORTUNITIES FOR IMPROVEMENT
Authors: Nihar Desai, Yongfei Wang, Frederick Masoudi, James de Lemos, Abhinav Goyal, Howard Julien, Kumar Dharmarajan, Erica Spatz, Jay Udell, Deepak Bhatt, John Rumsfeld, Jeptha Curtis
Journal: Journal of the American College of Cardiology (2016)
A new fully covered metal stent with anti-migration features for the treatment of malignant dysphagia
Authors: Daisy Walter, Maarten van den Berg, Jeanin van Hooft, Henk Boot, Robert Scheffer, Frank Vleggaar, Peter Siersema
Journal: Endoscopy (2014)

<b>Background and study aims:</b> A new esophageal stent with two anti-migration features was developed to minimize migration. The aim of this study was to evaluate the clinical efficacy and safety of this stent in patients with malignant dysphagia. <b>Patients and methods:</b> A total of 40 patients with dysphagia due to a malignant obstruction of the esophagus were prospectively enrolled in this cohort study. <b>Results:</b> Stent placement was technically successful in 39 patients (98 %). The median dysphagia-free time after stent placement was 220 days (95 % confidence interval 94 – 345 days). Nine patients (23 %) experienced recurrent dysphagia due to tissue overgrowth (n = 2), stent fracture (n = 1), and partial (n = 5) or complete (n = 1) stent migration. A total of 16 serious adverse events occurred in 14 patients (36 %), with hemorrhage (n = 3) and severe nausea or vomiting (n = 3) being the most common causes. <b>Conclusions:</b> This new stent design was effective for the palliation of malignant dysphagia and had a low rate of recurrent dysphagia. However, despite the anti-migration features, stent migration was still a major cause of recurrent dysphagia. Furthermore, treatment was associated with a high adverse event rate. Dutch Trial Registration (NTR 3313)
Dofetilide in Patients with Congestive Heart Failure and Left Ventricular Dysfunction
Authors: Christian Torp-Pedersen, Mogens Møller, Poul Erik Bloch-Thomsen, Lars Køber, Erik Sandøe, Kenneth Egstrup, Erik Agner, Jan Carlsen, Jørgen Videbæk, Bradley Marchant, A. John Camm
Journal: New England Journal of Medicine (1999)

Atrial fibrillation occurs frequently in patients with congestive heart failure and commonly results in clinical deterioration and hospitalization. Sinus rhythm may be maintained with antiarrhythmic drugs, but some of these drugs increase the risk of death.
Effects of Pancreas Transplantation on Postprandial Glucose Metabolism
Authors: Harold Katz, Mal Homan, Jorge Velosa, Paul Robertson, Robert Rizza
Journal: New England Journal of Medicine (1991)

Because a pancreas allograft is placed in the pelvis, pancreas transplantation abolishes the normal gradient between portal-vein and peripheral-vein insulin concentrations and causes systemic hyperinsulinemia. Whether pancreas transplantation restores carbohydrate metabolism to normal is not known.
Fiber: Unanswered Questions
Authors: Johanna T. Dwyer, Lynne M. Ausman
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Fiber: Unanswered Questions Get access Johanna T. Dwyer, Johanna T. Dwyer Search for other works by this author on: Oxford Academic PubMed Google Scholar Lynne M. Ausman Lynne M. Ausman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 24, 16 December 1992, Pages 1851–1853, https://doi.org/10.1093/jnci/84.24.1851 Published: 16 December 1992 Article history Received: 30 October 1992 Accepted: 17 November 1992 Published: 16 December 1992
INCREMENTAL PROGNOSTIC VALUE OF CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY HIGH RISK PLAQUE CHARACTERISTICS IN ASYMPTOMATIC PATIENTS
Authors: Kazuhisa Takamura, Shinichiro Fujimoto, Takeshi Kondo, Makoto Hiki, Rie Matsumori, Yuko Kawaguchi, Shoko Suda, Etsuro Kato, Kanako Kumamaru, Shinichi Takase, Hiroyuki Daida
Journal: Journal of the American College of Cardiology (2016)
Abstract P6-02-02: Evaluation of the Clinical Efficacy of Minimally Invasive Procedures for Breast Cancer Screening at a Teaching Hospital
Authors: BD Verenhitach, S Elias, AP Nazário, AC. Patrocinio
Journal: Cancer Research (2010)

Abstract Objective: To assess the clinical accuracy of diagnostic procedures for breast cancer at a teaching hospital using internal auditing tools and quality control measures. Study Design: Retrospective assessment of 500 patients who underwent core needle biopsy (wide-bore needle biopsy - WBN) of palpable or non-palpable breast nodes and also were submitted to at least one cytologic examination [fine needle aspiration cytology (FNA) and/or imprint of a WBN specimen]. For statistical assessment, we utilized the auditing tool and quality control proposed by the National Health Service — Breast Screening Program (NHSBSP). Results: For FNA, specificity full (SPEC), positive predictive value (PPV), inadequate rates and suspicious rates were satisfactory while absolute sensitivity (AS), complete sensitivity (CS), false-negatives (FNs) and false-positives (FPs) were unsatisfactory. For imprint, AS, CS, inadequate rate from cancers and suspicious rate were satisfactory, and the remaining indicators were unsatisfactory. WBN displayed the best performance with AS, CS, FN, suspicious rate, SPEC and PPV, showing satisfactory results and only one unsatisfactory result (FP). Comparison of quality control measures of fine-needle aspiration (n=395), imprint (n=182) and core-needle biopsy (n=500) performed at the UNIFESP-EPM Breast Clinic from January 2002 to April 2007 with the Min — minimuml; Unif — Unifesp-EPM; PPV — Positive predictive value, NA — not applicable Conclusion: Based on an overall analysis, WBN displayed the highest clinical efficacy compared with FNA and imprint and demonstrated adequate safety for confirming the appropriate diagnosis and management of patients, ensuring the efficacy of the service. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-02-02.
Novel protein may identify more aggressive prostate cancers
Authors: S. Gottlieb
Journal: BMJ (1998)

The level of p27 protein in patients with prostate cancer may identify those who have a more aggressive form of the disease with a higher rate of recurrence and poorer long term survival. Such patients may benefit from aggressive treatment, whereas others could be saved from unnecessary treatment.

Many researchers agree that the p27 protein has an important role in controlling the growth of at least four different cancers arising in the body's epithelial tissue. In the latest study researchers found that the protein was abundant in tissue taken from normal prostate glands and …
FAILURE OF CONVULSIVE RESPONSE IN ELECTROCONVULSIVE THERAPY IN A PATIENT TREATED WITH ACETAZOLAMIDE (DIAMOX<sup>®</sup>)
Authors: J. THOMAS UNGERLEIDER
Journal: American Journal of Psychiatry (1958)

A case history is presented which suggests that acétazolamide (Diamox®), here used in the treatment of glaucoma, elevated the convulsive threshold of a patient being treated with electroshock therapy for a psychotic depression. The anticonvulsant property of this drug should not be overlooked when considering a patient for electroconvulsive therapy.
Case 26-2010
Authors: Misha L. Pless, Daniela Kroshinsky, Regina C. LaRocque, Bradley R. Buchbinder, Lyn M. Duncan
Journal: New England Journal of Medicine (2010)

A 54-year-old man, who had recently been treated for Hodgkin's lymphoma, was admitted to this hospital because of acute unilateral loss of vision. On the morning before admission, the patient noted decreased central vision in his left eye. On examination, visual acuity in the left eye was 20/400. Funduscopic examination revealed a pale, edematous optic nerve and flame hemorrhages inferior to the nerve. An erythematous, flaking rash was present on the forehead, chest, and upper back. CT and MRI scans of the brain showed no abnormalities. A test result was received, and a diagnostic procedure was performed.
A8.25 The effect of abatacept therapy on granzyme B serum levels in patients with rheumatoid arthritis
Authors: S Piantoni, E Colombo, M Scarsi, A Tincani, P Airò
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Rheumatoid arthritis (RA) is characterised by increased numbers of circulating CD28neg T-cells, a population displaying functional characteristic of cytotoxic memory cells, including expression of granzymes, a family of serine proteases playing key roles in the induction of target-cell death. Soluble granzymes (as granzyme B (GrB)) are elevated in sera from patients with RA, in which are associated with development of radiographic erosions. Abatacept (CTLA4-Ig; ABA) competing with the engagement of CD28 on T-cells, influences the subsequent T-cell activation. In patients treated with ABA, the number of circulating CD28neg T-cells decreases, suggesting that the drug can prevent the generation of CD28neg T-cell populations. Since CD28neg T-cells may be an important source of GrB, we have evaluated the effect of ABA therapy on GrB serum levels in patients with RA. <h3>Materials and methods</h3> Fifty-three RA patients, treated for at least 3 months with ABA were evaluated. Disease activity and response to the treatment were measured with DAS28 (based on CRP) and EULAR Criteria. T-cell counts were determined by flow cytometry. Serum GrB samples were collected before the first administration of ABA (T0) and then after 6 months (T6), and measured by an indirect solid-phase enzyme immunoassay with a sensitivity limit of 20 pg/ml. <h3>Results</h3> The percentage and the absolute number of circulating CD4<sup>+</sup>CD28-neg T-cells decreased after ABA therapy (T0 vs. T6: p = 0.018; p = 0.018, respectively), as well as those of CD8<sup>+</sup>CD28-neg T cells (T0 vs. T6: p = 0.005; p = 0.008, respectively). At T0, GrB serum levels were detectable in all RA patients, and were correlated with disease activity (p = 0.0022), and percentages of circulating CD4<sup>+</sup>CD28- (p = 0.007) and CD8<sup>+</sup>CD28- T-cells (p = 0.031). In 25 patients serum level of GrB were evaluated at T6: in 18 patients with a moderate or good clinical response to ABA the levels of GrB significantly decreased from T0 (median: 62.8 pg/mL[10th-90th percentile:45.8–116]) to T6 (53.8 [46.4–96.6]; p = 0.023), whereas no variation was observed in 7 non responders. The variation of GrB levels was directly correlated with that of DAS28-PCR (p = 0.040), but not with those of circulating CD28-neg T-cell subsets. <h3>Conclusions</h3> Costimulation blockade by ABA can decrease the serum levels of GrB in RA patients responding to the treatment, suggesting that this might be one of the mechanism by which ABA can prevent radiographic erosions. However, the lack of correlation of such decrease with the numbers of circulating CD28-neg T-cells suggests that these cells are not the main source of serum GrB.
IgA Protease Production as a Characteristic Distinguishing Pathogenic from Harmless Neisseriaceae
Authors: Martha H. Mulks, Andrew G. Plaut
Journal: New England Journal of Medicine (1978)

IgA proteases are extracellular enzymes of bacteria that have human immunoglobulin A of the IgA1 subclass as their only known substrate. The identification of this enzyme in neisseria prompted us to determine whether IgA protease production correlates with pathogenicity within this genus. Multiple clinical isolates of Neisseria gonorrhoeae, N. meningitidis and eight species of non-pathogenic neisseria that commonly colonize the normal human nasopharynx were examined for IgA protease activity. All N. gonorrhoeae and N. meningitidis strains were enzyme positive; all non-pathogenic strains were negative. Among meningococci, the enzyme occurred in strains carried harmlessly in the nasopharynx as well as those isolated from systemic infections. Because mucosal immune defense is largely mediated by antibodies of the IgA isotype, the finding that IgA protease activity is linked specifically to the pathogenic neisseria suggests that the enzyme may be involved in the pathogenesis of neisserial infection.
The Colyte Renal Scan
Authors: CARLOS E. JIMÉNEZ, INKU HWANG
Journal: Clinical Nuclear Medicine (2000)

Fecal impaction is a rare cause of urinary tract obstruction that is reversible with removal of the stool. In this 7-year-old girl with bilateral duplicated collecting systems, non-neurogenic bladder (Hinman syndrome) and encopresis, the initial furosemide renal scintigraphic examination showed an obstructed left lower moiety. Because of this unusual pattern of obstruction in a duplicated system along with radiographic evidence of massive fecal impaction, a repeated furosemide renal study performed after aggressive Colyte bowel cleansing showed resolution of the left lower moiety obstruction. The authors believe theirs is the first reported case of fecal impaction causing urinary tract obstruction in Hinman syndrome demonstrated on renal furosemide scintigraphy.
THU0026 P62/SQSTM1 links reactive oxygen species formation and obesity to increased tnfalpha-mediated joint destruction via its signalling domains
Authors: A. Korb-Pap, A. Hillmann, M. Heitzmann, S. Bürgis, G. Kollias, S. Hermann, M. Schäfers, A. Gessner, T. Pap, T. Weide, H. Pavenstädt
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The multidomain protein p62/SQSTM1 modulates important signalling pathways responsible for osteoclastogenesis, cell proliferation and polarity. Furthermore, it also regulates protein degradation by autophagy, the ubiquitin proteasome system or sequestration. Although there is a link between p62 mutations and Paget's disease of bone, it is unclear how p62 acts as a signaling scaffold between the different pathways and how the single domains coordinate the protein functions and link different processes during chronic inflammation. <h3>Methods</h3> Therefore, we generated mice carrying a truncated form of p62, which lacks the binding sites for TRAF6 and aPKC, but still contains a functional ubiquitin binding site (p62<sup>Delta69-251</sup>). We characterized these mice and crossed them with arthritic hTNFtg animals to study the effects of the p62 signaling domain on the onset, severity and histologicals changes of a TNFalpha dependent arthritis. Isolated cells of these mice were analysed for alterations in their differentiation capacity, ROS production and MAPK signaling. <h3>Results</h3> The truncated p62<sup>Delta69-251</sup> protein was ubiquitously expressed and was still able to oligomerize and to bind LC3, ubiquitinated proteins, and ERK1 whereas TRAF6 binding was missing. Cells of homozygote p62<sup>Delta/69-251</sup>mice showed an increased production of ROS and elevated levels of autophagy-related acidic membrane vesicles. Stimulation of p62<sup>Delta69-251</sup> cells with the autophagy-inhibitor Bafilomycin and the proteasome-inhibitor MG132 still resulted in an accumulation of p62 and aggregate formation. Furthermore, the lack of the signaling module was sufficient to produce an obese phenotype accompanied by the enlargement of organs, e.g. liver and kidney. PET/CT studies revealed an increased bone metabolism and BMDMs of p62<sup>Delta69-251</sup> mice showed a significantly increased osteoclastogenesis in vitro, particularly when stimulated with TNFalpha. WB analysis revealed an increased TNFalpha- induced p38 phosphorylation in cells from p62<sup>Delta69-251</sup> compared to wt mice. Crossing of p62<sup>Delta69-251</sup>mice with hTNFtg animals resulted in a dramatic increase in the severity of joint damage conceivable by an increased number and size of osteoclasts. Interestingly, p62<sup>Delta69-251/+</sup>hTNFtg mice showed a significant increased weight at week 12 compared to hTNFtg mice. <h3>Conclusions</h3> The loss of p62 signaling domains has important consequences both for metabolic activation and for osteoclastogenesis under inflammatory conditions. <h3>Disclosure of Interest</h3> None Declared