Which treatment strategy for women with symptoms of urinary tract infection?
Authors: Lars Bjerrum, Morten Lindbæk
Journal: BMJ (2015)

Uncomplicated urinary tract infection (UTI) is the most common bacterial infection in women. Most women experience at least one episode during their lives, and each year about 10% receive one or more courses of antibiotics for UTI.1 2 Most women with typical symptoms are treated empirically, though up to half of them do not have clinically significant bacteriuria, and evidence indicates that many women with symptoms of UTI will recover without antibiotic treatment.3

Studies that compared antibiotics with placebo in women with uncomplicated UTI report a delayed cure in the placebo group, but most become symptom free within a week.3 4 Prescribing antibiotics to patients with self limiting conditions contributes to antimicrobial resistance. The World Health Organization considers antimicrobial resistance to be one of the three most important public health problems globally, and initiatives to reduce inappropriate and superfluous prescribing are essential if we are to maintain effective antibiotic treatment for future generations.

In a linked paper, Gagyor and colleagues (doi:10.1136/bmj.h6544) report a pragmatic double blind trial to investigate whether initial treatment with the non-steroidal anti-inflammatory drug (NSAID) ibuprofen can help to reduce antibiotic prescribing in women in primary care with symptoms suggestive of uncomplicated UTI.5 Nearly two thirds of women treated with ibuprofen did not receive antibiotics during the four week follow-up. They did, however, have a significantly higher burden of symptoms than women randomised to antibiotics (fosfomycin). Women given ibuprofen had their symptoms for a day longer, and about 60% (n=143) still had still symptoms after four days compared with about half of those given fosfomycin initially. After one week, only 70% (n=163) of women in the NSAID group were symptom free compared with 82% (n=186) of women in the antibiotic group.

Clearly, initial treatment with a NSAID can reduce the use of antibiotics in women with uncomplicated UTI, but the trade-off is a greater burden of symptoms.

The overall rate of acute pyelonephritis was low. Five women developed this complication after initial treatment with ibuprofen compared with one in the antibiotic group. The difference was not significant, but the trial was underpowered for this uncommon outcome. Initial treatment with fosfomycin led to a higher incidence of adverse effects such as nausea and diarrhoea (23% v 17% in ibuprofen group). One woman treated with ibuprofen experienced the serious adverse effect of gastrointestinal bleeding, which was considered to be related to the drug treatment.

Overall, the study suggests that about two thirds of women with symptoms of uncomplicated UTI who were treated with ibuprofen could recover without antibiotics. The reduced consumption of antibiotics in women initially treated with NSAIDs was, however, associated with a moderately higher symptom burden. In an earlier placebo controlled Swedish study in the same group of patients, 42% in the placebo group needed an antibiotic, a proportion comparable with antibiotic prescribing in the NSAID group in the present study.3

All the women in the trial of Gagyor and colleagues gave a urine sample for culture.5 Among women with positive results, those treated initially with ibuprofen had a significantly higher burden of symptoms than women given fosfomycin, and a substantial number of women treated with ibuprofen needed antibiotics during follow-up (0.49 courses per patient). Among women with negative results on urine culture, however, there was no significant difference in burden of symptoms between the two treatment groups, and antibiotic use in the women initially treated with ibuprofen was low (0.10 courses per patient). This indicates, perhaps not surprisingly, that urine culture can help to identify the individuals most likely to benefit from antibiotics.

Symptoms of uncomplicated UTI are uncomfortable, and most women will want to start effective treatment as soon as possible. The challenge in general practice is how to identify those who need antibiotics. Overtreatment could lead to adverse effects, and most patients are aware that overuse of antibiotics leads to antimicrobial resistance. Patients do not want antibiotics unless they are necessary. Antimicrobial treatment should therefore be initiated only if treatment is expected to reduce or shorten the symptom burden or reduce the risk of complications.6

In patients with severe and persistent symptoms, microbiological examination of urine can help the GP to identify the micro-organisms causing the infection. In Nordic countries, many GPs have direct access to point of care testing such as urine phase contrast microscopy, culture, and direct susceptibility testing to identify patients who need antibiotic treatment.7 8 9 In the study by Gagyor and colleagues, only a third of patients with uncomplicated UTI needed antibiotics during the four weeks of follow-up,5 so a strategy of delayed prescription for patients with light to moderate symptoms might also be a feasible strategy. We need trials of delayed prescriptions for UTI.10 Delayed prescribing has been shown to reduce antibiotic prescriptions for respiratory tract infections by 50-70%.11 12(this is same sentence repeated in adifferent way!)