tbuckley/cabot-search huggingface dataset:
Autoimmune diseases and myelodysplastic syndromes
Authors: Rami S. Komrokji, Austin Kulasekararaj, Najla H. Al Ali, Shahram Kordasti, Emily Bart‐Smith, Benjamin M. Craig, Eric Padron, Ling Zhang, Jeffrey E. Lancet, Javier Pinilla‐Ibarz, Alan F. List, Ghulam J. Mufti, Pearlie K. Epling‐Burnette
Journal: American Journal of Hematology (2016)

Immune dysregulation and altered T‐cell hemostasis play important roles in the pathogenesis of myelodysplastic syndromes (MDS). Recent studies suggest an increased risk of MDS among patients with autoimmune diseases. Here, we investigated the prevalence of autoimmune diseases among MDS patients, comparing characteristics and outcomes in those with and without autoimmune diseases. From our study group of 1408 MDS patients, 391 (28%) had autoimmune disease, with hypothyroidism being the most common type, accounting for 44% ( n = 171) of patients (12% among all MDS patients analyzed). Other autoimmune diseases with ≥5% prevalence included idiopathic thrombocytopenic purpura in 12% ( n = 46), rheumatoid arthritis in 10% ( n = 41), and psoriasis in 7% ( n = 28) of patients. Autoimmune diseases were more common in female MDS patients, those with RA or RCMD WHO subtype, and those who were less dependent on red blood cell transfusion. Median overall survival (OS) was 60 months (95% CI, 50–70) for patients with autoimmune diseases versus 45 months (95% CI, 40–49) for those without (log‐rank test, P = 0.006). By multivariate analysis adjusting for revised IPSS and age &gt;60 years, autoimmune diseases were a statistically significant independent factor for OS (HR 0.78; 95% CI, 0.66–0.92; P = 0.004). The rate of acute myeloid leukemia (AML) transformation was 23% ( n = 89) in MDS patients with autoimmune disease versus 30% ( n = 301) in those without ( P = 0.011). Patient groups did not differ in response to azacitidine or lenalidomide treatment. Autoimmune diseases are prevalent among MDS patients. MDS patients with autoimmune diseases have better OS and less AML transformation. Am. J. Hematol. 91:E280–E283, 2016. © 2016 Wiley Periodicals, Inc.
Aspergillus spp. invasive external otitis: favourable outcome with a medical approach
Authors: E. Marchionni, P. Parize, A. Lefevre, P. Vironneau, M.E. Bougnoux, S. Poiree, H. Coignard-Biehler, S.E. DeWolf, K. Amazzough, F. Barchiesi, V. Jullien, A. Alanio, D. Garcia-Hermoso, M. Wassef, R. Kania, O. Lortholary, F. Lanternier
Journal: Clinical Microbiology and Infection (2016)
Transplanted Tumor Growth and Liver Regeneration in the Rat&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Leon L. Gershbein
Journal: JNCI Journal of the National Cancer Institute (1963)

Subcutaneous transplantation of Walker 256 and Flexner-Jobling carcinomas or the Jensen sarcoma into young adult male rats at, or 5 days before, partial hepatectomy did not significantly alter the extent of liver regeneration over a period of 10.5 days. When the Walker or Jensen tumor cells were injected into the caudal or either of the caudate lobes, hepatic regeneration was not affected, but tumor growth was markedly accelerated in the partially hepatectomized rats, except for 1 series of old animals. When partial hepatectomy was carried out 72 to 96 hours after transplantation of Walker tumor cells or fragments in the caudal lobe, the lesion weights were in the control range at necropsy performed on the 7th or 8th day. However, no statistically significant increase in tumor growth rate occurred where the lesion was transplanted subcutaneously in animals killed over intervals up to 16 days. The hepatic water content increased in partially hepatectomized rats but was not further elevated by the presence of tumor either subcutaneously or in the liver.
Immunofluorescence Studies of Benign and Malignant Human Mammary Tissue 2
Authors: Alan V. Richman
Journal: JNCI Journal of the National Cancer Institute (1976)

Indirect immunofluorescence studies on sections of human normal breast tissue, benign breast lesions, and breast adenocarcinomas were performed with the use of monospecific fluorescein-conjugated antisera to human α, γ, and µ chains, albumin, and C3. In all tissues, benign and malignant, immunohistologic localization of IgA and IgM was noted in patterns previously described for other secretory epithelia. IgG was localized at the tumor cell, but was not associated with epithelial cells from either normal breast tissue or benign breast lesions. Except for a single case of benign cystosarcoma phylloides, all normal, benign, and malignant breast tissues failed to react with anti-C3. These findings were compared with previous studies employing dissociated tumor cells, and the potential application of these methods to pathologic diagnosis was examined.
Capecitabine plus gemcitabine in heavily pre-treated colorectal cancer. Results of an exploratory study
Authors: Y. Fernández, J. M. Vieitez, J. Fra, I. Palacio, B. Mareque, E. Uña, J. M. Buesa, A. J. Lacave
Journal: Journal of Clinical Oncology (2004)

3679 Background: Because daily oral capecitabine can mimic continuous infusion of 5-Fu and because gemcitabine can inhibit ribonucleotide reductase (Clin Cancer Res 1998; 4: 2811) resulting in enhanced binding of 5-Fu derivates to timidylate synthase and higher incorporation into DNA, a exoloratory study was initiated in September 2001. Methods: Elegibility criteria: (1) Histologically proven colorectal cancer; (2) Karnofsky performance status ≥60; (3) measurable disease; (4) Progressive disease to at least one 5-Fu based regimen. Schedule consisted in Gemcitabine 900 mg/m/2 IV day 1 (90 minutes) and capecitabine 1250 mg/m2/12 hours PO days 1–7. Repeated every 2 weeks. Results: 21 patients were registered until IX-03 (4 women, 17 men). Median age was of 68 years (range 47–78). 16 patients presented hepatic metastases, 6 peritoneal metastases, 4 lung, 4 soft tissue and 1 bone metastases. There was 9 patients in second line, 9 patients in third line, and 3 patient in fourth line. Two patients responded (one patient after progression to Saltz, and FOLFOX regimen, and another one after intraarterial 5Fu + IV oxaliplatin and CAPIRI), one presented a minor response after PD to CPT11 + Fu + FC (Saltz) and FOLFOX. Median time to progression (MTP) and survival (OS) was of 4 months (range 1–12) and 9 months (range 3–21). Grade IV mucositis was registered in 1 patient, median leucocytes neutrophils platelets and haemoglobin was of 4.300/microgram (range 2.1–6.9), 2.100/microgram (range 0.8–4.1), 139/dL (range 50–176), and 10.7 gr/dl (7.6–13). No grade 3–4 diarrhea or nausea was observed. Other adverse events were mild and no treatment related death occurred. Conclusion: This combination regimen has an excellent tolerance in this heavily pretreated patients; the MTP, survival (OS) and the founding of some degree of activity are encouraging. Further studies of this treatment regimen are warranted. No significant financial relationships to disclose.
B-Lymphocytes and T-Lymphocytes in Three Types of Bovine Lymphosarcoma 2
Authors: I. Takashima, C. Olson, D. M. Driscoll, L. E. Baumgartener
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article B-Lymphocytes and T-Lymphocytes in Three Types of Bovine Lymphosarcoma Get access I. Takashima, I. Takashima 3Department of Veterinary Science, University of Wisconsin, 1655 Linden Drive, Madison, Wis. 53706. Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Olson, C. Olson 3Department of Veterinary Science, University of Wisconsin, 1655 Linden Drive, Madison, Wis. 53706. Search for other works by this author on: Oxford Academic PubMed Google Scholar D. M. Driscoll, D. M. Driscoll 3Department of Veterinary Science, University of Wisconsin, 1655 Linden Drive, Madison, Wis. 53706. Search for other works by this author on: Oxford Academic PubMed Google Scholar L. E. Baumgartener L. E. Baumgartener 3Department of Veterinary Science, University of Wisconsin, 1655 Linden Drive, Madison, Wis. 53706. 4We appreciate the excellent technical assistance of Mr. John Wilson, Mrs. Janice Lokken, and Mr. Randall Kaja. The cooperation of Dr. R. J. Marshall, Dr. K. D. Campbell, and Dr. F. L. Adams of the USDA Meat Inspection in obtaining materials is appreciated. We also thank Dr. Peter Raich, University Hospital, University of Wisconsin, for assistance with the histochemistry. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 59, Issue 4, October 1977, Pages 1205–1209, https://doi.org/10.1093/jnci/59.4.1205 Published: 01 October 1977 Article history Received: 27 August 1976 Revision received: 11 February 1977 Accepted: 14 April 1977 Published: 01 October 1977
Simulating the effect of exercise on urea clearance in hemodialysis.
Authors: S W Smye, E J Lindley, E J Will
Journal: Journal of the American Society of Nephrology (1998)

A two-compartment model of urea kinetics during hemodialysis is used to predict the effect of exercise on hemodialysis dose. It is assumed that the two compartments represent tissues that are perfused by low and high blood flows (initially 1.1 L/min and 3.8 L/min). The effect of changing the distribution of flows between the compartments, emulating the effect of exercise, is simulated using the model equations for a range of dialyzer clearances. Compartmental volumes are assumed constant (33.4 L and 8.6 L for low- and high-flow compartments, respectively). The analysis identifies muscle perfusion as a rate-limiting factor during the later stages of hemodialysis and illustrates the benefit of exercise during this phase in increasing dialysis efficiency. The model suggests that the postdialysis rebound in the blood urea concentration is eliminated by increasing flow to the low-flow compartment from 1.1 L/min to 7.1 L/min and sustaining this for at least 30 min of a 150-min dialysis session, independent of the dialyzer clearance. Additional exercise will not increase the dialysis dose. Experimental studies are required to confirm the analysis.
The European Organisation for Research and Treatment of Cancer (EORTC) translation procedure for standardized quality of life questionnaires
Authors: M. Koller, N. K. Aaronson, J. Blazeby, A. Bottomley, C. Johnson, J. Ramage, K. West
Journal: Journal of Clinical Oncology (2006)

16033 Background: The EORTC Quality of Life (QoL) Group has developed a modular approach to QoL measurement for use in clinical trials in cancer. Questionnaires are used in international trials and standardized translation procedures are therefore required. This report summarizes the EORTC translation procedure, its accomplishments and translation problems. Methods: Translations follow a forward-backward procedure, independently carried out by two native-speakers of the target language. Discrepancies are arbitrated by a third consultant, and solutions are reached by consensus. Translated questionnaires undergo pilot-testing. Suggestions (by patients and users) are incorporated into the final questionnaire version. Most translations are performed by professional translators. The translation procedure is managed and supervised by the Translation Committee within the EORTC QoL Group. Results: To date, the core EORTC QoL questionnaire, the QLQ-C30, has been translated and validated into 62 languages, with a further 12 translations in progress. Translations include all major Western languages, East European languages, Asian languages and also remote languages, such as Xhoza (Africa).The validated, condition-specific questionnaire modules have been translated in up to 37 languages. The following major translation problems were encountered: lack of expressions for specific symptoms in various languages, the quest for formal versus informal versions, recent spelling reforms in several European countries, and different weights of social issues between Western and Eastern cultures. The EORTC measurement system is now registered for use in over 9000 clinical studies in 80 countries worldwide. Conclusions: The EORTC provides a strong infrastructure and methodology to produce high quality translations of their QoL questionnaires for use in international clinical trials. Translation problems have been identified and it will be an important topic for future research to specify whether these problems arise out of procedural/methodological shortcomings or are due to subtle cross-cultural differences in concepts of health, illness and QoL. No significant financial relationships to disclose.
An integrated nursing care model for lung cancer patients
Authors: P.K. Maggie Lit, K.H. Lee, P.S. Chow, W.M. Johnny Chan
Journal: European Respiratory Journal (2014)

Introduction Lung cancer is a leading cause of cancer death in Hong Kong. As a disease jointly managed by different disciplines, there is a need to improve the coordination of care. An integrated lung cancer case management program has commenced in our Hospital since Feb 2013 to facilitate the continuity of care in newly diagnosed lung cancer patients. Objective: To examine the role of lung cancer case manager (LCCM). Methodology: A retrospective study from 1 March 2012 to 30 September 2013. The pathway includes 5 key elements:(1)Patient triage;(2) Assistance in arranging diagnostic investigations;(3)Monitoring the progress and collaborating investigation results for multi-disciplinary team (MDT) case conference; (4) Making referrals and liaisons with various healthcare providers;(5) Continuous assessment, monitoring, education and support in nurse clinics. Results Ninety-two patients were diagnosed of lung cancer, predominantly male (62%) and metastases already noted in 76%. Only 15 patients (16%) underwent surgery. All were scheduled to nurse clinic with 195 episodes of attendances. Advancements of diagnostic investigations were facilitated for 14 patients. Liaison with the corresponding surgical LCCM for operative arrangements was done in 49 (52%). 7 (7.6%) were referred to social workers for counselling and financial support, 5 (5.4%) to dieticians for low BMI before surgical operation and chemotherapy, 1(1.1%) to clinical psychologist for critical stress management. 87 (94.5 %) patients acknowledged sufficient knowledge and expressed satisfaction on the service provision. Conclusion LCCM is a useful and cost-effective way to reduce the possible fragmentation of service provisions by MDT in the management of lung cancer.
History of suicidal behavior in depressed borderline inpatients
Authors: R C Friedman, M S Aronoff, J F Clarkin, R Corn, S W Hurt
Journal: American Journal of Psychiatry (1983)

The DSM-III definition of borderline personality disorder emphasizes affective symptoms. The authors hypothesized that depressed patients with borderline personality disorder would be more likely to be suicidal than those without this diagnosis. Of 53 inpatients treated for depression, 46 manifested personality disorders; borderline personality disorder was the most prevalent axis II diagnosis. That borderline patients had more complicated courses than the other depressed patients was evidenced by their histories of suicidal behavior. Most patients diagnosed as having borderline personality disorder continued to fulfill criteria for this diagnosis even when suicide attempts were excluded as a diagnostic criterion.
Palliating oncologists: A pilot study on primary palliative care development in hematology-oncology trainee outpatient clinics.
Authors: Erin R. Alesi, Sherri Rauenzahn, Laurel Lyckholm
Journal: Journal of Clinical Oncology (2014)

21 Background: Primary Palliative Care (PPC) denotes basic PC competencies; whereas secondary PC (SPC) denotes consultant expertise. PPC competency includes basic symptom assessment/management; fundamental communication skills; and identification of patients for SPC. ASCO recommends early concurrent PC in advanced cancer/high symptom burden as it improves quality of life, symptom management, and care satisfaction. Because PC need exceeds availability of SPC providers, PPC proficiency by oncologists is essential. To enhance Hematology-Oncology (HO) fellows’ clinical experience through more effective PC training/utilization, we piloted an integrated fellows’ pre-clinic conference. Methods: HO fellows’ pre-clinic conferences were divided into intervention and control groups. Over 8 weeks, the PC fellow participated in interdisciplinary discussion for 2 weekly 1-hour conferences. The PC fellow provided PPC education via brief formal and informal didactics and identified patients for SPC referral. All HO fellows were surveyed before and after the intervention to assess comfort level with PPC and SPC referral. The survey used Likert-type scales and short-answer questions. Results: All HO fellows (N=10) voluntarily participated: 6 in the intervention group (IG), and 4 in the control group (CG). The IG demonstrated clearly enhanced comfort level with managing symptoms by improving in 100% of PPC categories after the intervention compared to 27% in the CG. Referral to SPC also increased in the IG, while it decreased in the CG. All HO fellows in the IG liked the PC integration, wanted to continue it, and wanted SPC availability in their future practice. Conclusions: This integration not only enhanced HO fellows’ PPC training and increased referral to SPC; it also fostered a partnership between HO and PC providers early in their careers. Such collaborative efforts are likely to improve long-term comprehensive cancer care as well as patient and provider satisfaction. Further study is merited and should include multiple centers and patient evaluations.
Alcohol use in the Army: patterns and associated behaviors
Authors: J F Greden, S I Frenkel, D W Morgan
Journal: American Journal of Psychiatry (1975)

The authors assessed by questionnaire the alcohol use of 1,873 U.S. soldiers in the United States and Viet Nam. According to operational definitions based on total ethyl alcohol consumption and several behaviors associated with drinking, 7 percent were classed as alcoholics, 5 percent as borderline alcoholics, and 24 percent as potential alcoholics. Contrary to popular stereotypes, there was a disproportionate number of younger and lower ranking soldiers in these three groups; there was also a positive relationship between drinking and use of illicit drugs across groups. The authors state that future studies of alcohol use should include determinations of total ethyl alcohol intake to permit generalizability of their results.
Abstract 9765: The Impact of Premature Lung Disease on the Maturation of Cardiac Function in the First Year of Life: Discerning Early Predictive Markers of Chronic Lung Disease
Authors: Philip T Levy
Journal: Circulation (2014)

Background: The aims of this study were to discern the impact of premature lung disease on cardiac development in the first year of life and to determine if quantitative echocardiographic measures of function could predict the severity of chronic lung disease in premature infants. Methods: 100 premature infants (26 ± 2 weeks at birth) were prospectively enrolled and followed over the first year of life through the Premature and Respiratory Outcomes Program (NIH 1U01 HL1014650). Ventricular systolic function was assessed using myocardial strain. Measurements of right (RV) and left (LV) ventricular strain were acquired and compared at 5 time points: day of life one and three (n=30), 32 and 36 weeks post-menstrual age (n=100), and 1 year corrected age (n=50). The primary outcome was bronchopulmonary dysplasia (BPD), as defined by the 2001 NIH Workshop Criteria and the 2004 Physiological Definition. Infants were grouped and compared by the development and severity of BPD at 36 weeks PMA (no/mild vs. moderate/...
The Role of Exercise in Cardiac Aging
Authors: Jason Roh, James Rhee, Vinita Chaudhari, Anthony Rosenzweig
Journal: Circulation Research (2016)

Aging induces structural and functional changes in the heart that are associated with increased risk of cardiovascular disease and impaired functional capacity in the elderly. Exercise is a diagnostic and therapeutic tool, with the potential to provide insights into clinical diagnosis and prognosis, as well as the molecular mechanisms by which aging influences cardiac physiology and function. In this review, we first provide an overview of how aging impacts the cardiac response to exercise, and the implications this has for functional capacity in older adults. We then review the underlying molecular mechanisms by which cardiac aging contributes to exercise intolerance, and conversely how exercise training can potentially modulate aging phenotypes in the heart. Finally, we highlight the potential use of these exercise models to complement models of disease in efforts to uncover new therapeutic targets to prevent or treat heart disease in the aging population.
Pulmonary function and quality of life in children and adolescents adenovirus bronchiolitis obliterans
Authors: Stefhanie Nayar, Ana María Escobar, Monica Saavedra, Alberto Vidal
Journal: European Respiratory Journal (2011)

Introduction: There are few studies assessing pulmonary function and quality of life of PIBO patients.

Objective: Assess the pulmonary function and the quality of life of patients with PIBO and the correlation between both variables.

Methods: 14 Children with PIBO in follow up at the pediatric pulmonology, were included in this study. Study period: April 2009 - April 2010. Pulmonary function was assessed with spirometry, flow/volume curve and intrathoracic gas volume. A survey of self-administered Quality of Life was applied at the visit to investigate their global, physical and psychosocial quality of life. The Pearson linear correlation between quality of life and the pulmonary function test parameters was assessed, for statistical analysis p<0.05 was considered significant.

Results: The mean age of our patients was 12.4. The functional alterations were characteristics of an obstructive respiratory disorder in 85.7% and only 14.3% showed normal pulmonary functionof the patients. The quality of life parameters were in average 58.6% of overall quality of life, 60.9% of physical quality of life and 57.9% of psychosocial quality of life. We found a positive correlation between global quality of life and VEF1, FVC and FEF25-75% (correlation index 0.54, 0.53 and 0.53 respectively) as well between physical quality of life and VEF1, FVC, FEV1/FVC and FEF25-75% (correlation index 0.86, 0.81, 0.70 and 0.74 respectively).

Conclusions: Most patients with PIBO showed pulmonary function impairment characterized by an obstructive respiratory pattern. Better quality of life correlates with better values in spirometric parameters.