FATAL AGRANULOCYTOSIS DUE TO PHENYLINDANEDIONE: REPORT OF A CASE
Authors: Perry C. Smith
Journal: Annals of Internal Medicine (1959)

Case Reports1 September 1959FATAL AGRANULOCYTOSIS DUE TO PHENYLINDANEDIONE: REPORT OF A CASEPERRY C. SMITHPERRY C. SMITHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-3-617 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhenylindanedione is one of several oral anticoagulants in wide use at the present time. It is generally considered to be non-toxic,1-5 but adverse reactions to the drug have been reported. We have been able to find six instances of agranulocytosis,6-10 two of jaundice,11, 12 and six of rash without fever13 in the world literature. One of the instances of agranulocytosis was fatal.7 The purpose of this communication is to report the second known case of fatal agranulocytosis due to phenylindanedione.CASE REPORTA 64 year old white male was admitted to Brooke Army Hospital July 30, 1957, because of a...Bibliography1. O'ConnorThompsonBaker WRCELA: Experience with the new anticoagulant phenylindanedione in acute myocardial infarction, Quart. Bull., Northwestern Univ. M. School 26: 193-196, 1952. MedlineGoogle Scholar2. PrestonO'ConnorThompsonChristensen FWWRCEEN: Clinical use of the anticoagulant phenylindanedione: report of 74 cases, Circulation 6: 515-519, 1952. CrossrefMedlineGoogle Scholar3. BlausteinShnayersonWallach ANR: Clinical use of a new anticoagulant, phenylindanedione, Am. J. Med. 14: 704-706, 1953. CrossrefMedlineGoogle Scholar4. JaquesGordonLepp LBEE: A new prothrombopenic drug, phenylindanedione, Canad. M. A. J. 62: 465-470, 1950. MedlineGoogle Scholar5. Blaustein A: A new prothrombopenic agent, Canad. M. A. J. 62: 470-472, 1950. MedlineGoogle Scholar6. TownsendFayDowningLaingCameron SRKJJRRDG: Phenylindanedione: a useful anticoagulant, Canad. M. A. J. 69: 149-151, 1953. MedlineGoogle Scholar7. MacMillanBrown RLKW: Agranulocytosis in two patients receiving phenylindanedione, Canad. M. A. J. 69: 330, 1953. MedlineGoogle Scholar8. Kirkeby K: Agranulocytosis following treatment with phenylindanedione, Lancet 2: 580-581, 1954. CrossrefGoogle Scholar9. AgerIngram JAGI: Agranulocytosis during phenindione therapy, Brit. M. J. 1: 1102-1103, 1957. CrossrefMedlineGoogle Scholar10. Johnman L: Sensitivity to phenindione: report of a case, Scottish M. J. 2: 330-331, 1957. CrossrefMedlineGoogle Scholar11. MakousVander Veer NJB: Severe drug sensitivity reaction to phenindione (phenylindandione), J. A. M. A. 155: 739, 1954. CrossrefMedlineGoogle Scholar12. EastBeamish ENRE: Severe sensitivity reaction (hepatitis, dermatitis and pyrexia attributable to phenylindanedione, Canad. M. A. J. 77: 1028, 1957. MedlineGoogle Scholar13. Dedichen J: Thrombosing arteriosclerosis, Brit. M. J. 2: 1038-1039, 1956. CrossrefMedlineGoogle Scholar14. McNicholFingerBazil LJJG: A comparative study of the clinical effectiveness of Dicumarol and Hedulin, J. Michigan State M. Soc. 56: 1559-1560, 1957. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC USA Fort Sam Houston, Texas*Received for publication April 23, 1959.From the Department of Medicine, Brooke Army Hospital, Brooke Army Medical Center, Fort Sam Houston, Texas.Requests for reprints should be addressed to Perry C. Smith, Captain MC, USA, Brooke Army Hospital, Brooke Army Medical Center, Fort Sam Houston, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProblems in Long-Term Anticoagulant TherapyCURRENT VIEWS ON BLOOD COAGULATION AND HAEMORRHAGIC DISORDERS 1 September 1959Volume 51, Issue 3Page: 617-620KeywordsAdverse reactionsAnticoagulant therapyAnticoagulantsHospital medicineRashesThrombosis ePublished: 1 December 2008 Issue Published: 1 September 1959 PDF downloadLoading ...