tbuckley/cabot-search huggingface dataset:
The Stupp regimen preceded by early post-surgery temozolomide versus the Stupp regimen alone in the treatment of patients with newly diagnosed glioblastoma multiforme (GBM).
Authors: LF Zhou, Yu Yao, Shuyuan Yang, Xuejun Yang, Xiang Wang, Xiang Zhang, Liwei Zhang, Yicheng Lu, Zhong-ping Chen, Jianmin Zhang, Songtao Qi, Renzhi Wang, Chao You, Ying Mao, Jisheng Wang, Juxiang Chen, Qun-ying Yang, Hong Shen, Zhiyong Li, Ma WB
Journal: Journal of Clinical Oncology (2013)

2022 Background: In treatment of newly diagnosed GBM with the Stupp chemo-radiotherapy regimen, following by adjuvant chemotherapy, patients were treated with temozolomide (TMZ) &amp; combined radiotherapy 4-5 weeks after surgery. In the interval between surgery and chemo-radiotherapy, it is not known whether additional TMZ treatment will improve efficacy or safety. This trial evaluated the safety and efficacy of the Stupp regimen + early post-surgery TMZ chemotherapy in the treatment of patients with newly diagnosed GBM. Methods: The trial was a multi-center, randomized open-label study. 99 newly diagnosed GBM patients were enrolled and randomly assigned to the Stupp regimen + early post-surgery TMZ chemotherapy arm (experimental group, n = 52) or to Stupp regimen alone (control group, n = 47). Fourteen days after surgery, the patients in experiment group recieved TMZ orally at 75mg/m 2 /day for 14 days. The primary endpoint of the study was the overall survival (OS). The secondary endpoints included the progression-free survival (PFS), objective tumor assessment and adverse events (AEs). Results: The median OS time was 17.58 months (95% CI: 15.18 – 23.03 months) in the experiment group and 13.17 months (95% CI: 11.14 – 18.76 months) in the control group (log-rank test, p = 0.021). There is no significantly difference in the median PFS between experiment group and control group (8.74 months, 95% CI: 6.41-14.85 months vs 10.38 months, 95% CI: 8.18-15.44 months, p = 0.695). No statistically significant difference was detected as regards to the objective tumor assessments. There is no significance in OS or PFS between MGMT positive and MGMT negative groups. TMZ treatment was well tolerated in the study. AE types and rates were generally similar between the two groups. There were 22 SAEs in this study, with only 1 SAE (lung infection) in Stupp regimen group was possibly drug-related. Conclusions: The addition of early post-surgery TMZ chemotherapy to the Stupp regimen for newly diagnosed GBM resulted in a statistically significant survival benefit with minimal additional toxicity. Clinical trial information: NCT00686725.
预测英格兰和威尔士2型糖尿病的发生风险：QD Score前瞻性推导和验证
Authors: Julia, Hippisley-Cox, Carol, Coupland, John, Robson, Aziz, Sheikh, Peter, Brindle, 曾静波, 李玉秀
Journal: BMJ (2009)

目的 开发并验证一个新的糖尿病风险模型（QDScore），用来估计10年内获得糖尿病诊断的风险，该模型的基础建立于多样化的种族和社会经济地位人群。 设计 前瞻性开放性队列研究，使用的数据常规收集于355个英格兰和威尔士全科诊所，然后使用176个独立诊所的数据来验证这一评分。 参与者 该推导模型共包括2540753例患者，年龄25—79岁，产生16436315患者年，其中78081例为新诊断2型糖尿病；验证队列包括1232832例患者（7643037患者年），其中37535例患者为新发2型糖尿病。 结局评估指标 用Cox比例风险模型估计建立队列中风险因子的效应，并且在男性和女件中推导出一个风险公式。终模型中包括的检验预测变量有：自我报告的种族、年龄、性别、体重指数、吸烟状态、糖尿病家族史、Townsend剥夺评分、已接受治疗的高血压、心血管疾病和口前使用糖皮质激素；关注的结局评估指标是在全科诊所记录中新发生的糖尿病。校正和区分度的测定在验证队列中进行计算。 结果 不同种族间2型糖尿病的风险存在4到5倍的变异。与白人参照组相比，巴基斯坦女性的调整风险比为4．07（95％可信区间3．24～5．11），巴基斯坦男性为2．54（2．20～2．93）。巴基斯坦和盂加拉困男性与印度男性相对风险比显著增高。非洲黑人男性和中国女性与对应的白人参照组相比风险增加。在验证数据中，该模型解释了51．53％的女性差异（95％可信区间50．90～52．16）和48．16％的男性差异（47．52～48．80）。风险积分显示了良好的区分能力，女性中D值达2．11（95％可信区间2．08～2．14），男性中为1．97（1．95～2．00）。模型经过很好的校正。 结论 QDScore是第一个基于前瞻性队列研究并且包括了社会等级和种族来预测糖尿病10年风险的风险预测模型。该模型不需要实验�
Abstract 9570: Adenosine Triphosphate Facilitates Dormant Conduction across Left Atrial Lines in Patients With Atrial Fibrillation Who Underwent Catheter Ablation
Authors: Yoshiyuki Hama, Yuji Matsudo, Taishi Kuwahara, Haruka Fujimaki, Satoshi Tokimasa, Bi Katsu, Shuzo Tanaka, Norimasa Tonoike, Kyokushi Hou, Tai Sekine, Masashi Yamamoto, Toshiharu Himi
Journal: Circulation (2013)

Introduction: The addition of left atrial lines including a roof line, bottom line, and mitral isthmus line after pulmonary vein (PV) isolation may lead to a favorable outcome of atrial fibrillation (AF) ablation. Transient reconduction of the isolated pulmonary vein (PV) is induced by administration of adenosine triphosphate (ATP) and elimination of dormant conduction improves outcome of AF ablation. The potential role of ATP in other arrhythmic substrates, such as left atrial lines, remains unclear. The aim of this study was to investigate the characteristics and frequency of dormant left atrial line conduction. Methods: Sixty-four patients (50 men; mean age 65±10; 3 paroxysmal, 26 persistent, 35 Longstanding persistent) who underwent first ablation of left atrial lines were enrolled in this study. A roof line, bottom line and mitral isthmus line were performed in 63 patients, 44 patients and 64 patients, respectively. Irrigated ablation catheters were used through steerable sheaths with a max power of 35W at the endocardial surface and 30W in the coronary sinus. ATP (20mg) was given greater than 10 minutes after completion of left atrial lines to reveal dormant conduction. Results: Completion of a roof line, bottom line and mitral isthmus line was achieved in 97% (61/63), 98% (43/44), and 95% (61/64), respectively. Following administration of ATP, dormant conduction was observed in 3.2% at a roof line, 2.3% at a bottom line, and 3.2% at a mitral isthmus line. Persistent reconduction was observed in 1.6% at a roof line and 2.3% at a bottom line. Transient reconduction was observed in 1.6% at a roof line and 3.2% at a mitral isthmus line. Following additional ablation, dormant left atrial line conduction was eliminated in all patients. The frequency of dormant left atrial line conduction was similar to that of dormant PV conduction (6.3% vs 7.8%., P=0.7) Conclusion: Administration of ATP could reveal dormant left atrial line conduction. Dormant conduction was evenly induced among PVs and left atrial lines.
Comparisons of cardiac indices between Asians and non-Asians with high risk of cardiovascular disease: the ONTARGET cardiac MRI substudy
Authors: B. R. Cowan, A. A. Young, Craig S. Anderson, R. Doughty, R. Krittayaphong, E. Lonn, T. Marwick, J. E. Sanderson, R. Schmieder, C. Reid, A. Wadham, SG Worthley, C. Yu, F. Zhao, G. Jennings, Ontarget Study Investigators
Journal: Journal of the American College of Cardiology (2006)
Malignant Rabbit Fibroma Virus: Observations on the Culture and Histopathologic Characteristics of a New Virus-Induced Rabbit Tumor&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: D S Strayer, G Cabirac, S Sell, J L Leibowitz
Journal: JNCI Journal of the National Cancer Institute (1983)

The clinical, histopathologic, and cultural characteristics of a newly isolated poxvirus, malignant rabbit fibroma virus (MV), were investigated. MV was isolated from tumors induced by an uncloned stock of Shope fibroma virus (SFV). MV, SFV, and rabbit myxoma virus were compared. Similarly to myxoma virus, MV grew to higher titer in vitro than did SFV and produced plaques rather than foci on rabbit kidney cell monolayers. Unlike the local, self-limited fibroblastic proliferations observed in SFV recipients, MV and myxoma caused a fulminant clinical syndrome characterized by malignant histology, metastases, and supervening fatal gram-negative infection with Pasteurella multocida. MV induced a large, protuberant local tumor and discrete metastases histologically resembling myxosarcomas. Draining lymph nodes contained metastases and showed diffuse cortical hyperplasia. Kupffer's cells were prominent in the liver, and macrophages were abundant in the splenic sinusoids. The lungs and trachea were spared, but the conjunctiva and nasal mucosa showed squamous metaplasia and atypia, with overlying Pasteurella infection and underlying tumor. Myxoma virus infection produced similar mucosal changes, but both of these as well as the epidermis overlying the myxomas showed cytoplasmic virus inclusions. Neither the skin nor the epithelial surfaces overlying MV-induced tumors nor the tumors themselves contained virus inclusions. Thus the tumor syndrome caused by MV differed from other known rabbit tumors. Endonuclease restriction digests showed that the MV genome resembled, but was distinct from, rabbit myxoma virus. Opportunistic infection associated with MV-induced disseminated tumor may be an experimental model for the infectious complications that often supervene in host-tumor relationships.
Monitoring methotrexate levels in osteosarcoma.
Authors: R Gorlick, P Meyers, M Kellick, J R Bertino
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.6.2290 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9626240 Monitoring methotrexate levels in osteosarcoma. R GorlickxR GorlickSearch for articles by this author , P MeyersxP MeyersSearch for articles by this author , M KellickxM KellickSearch for articles by this author , J R BertinoxJ R BertinoSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.6.2290 PDF "Monitoring methotrexate levels in osteosarcoma.." Journal of Clinical Oncology, 16(6), pp. 2290–2291© 1998 by American Society of Clinical Oncology
Rectal cancer in hereditary nonpolyposis colorectal cancer.
Authors: J. Veerapong, T. M. Vu, D. S. Saraiya, P. M. Lynch, Y. You, M. A. Rodriguez-Bigas
Journal: Journal of Clinical Oncology (2010)

e14028 Background: Hereditary nonpolyposis colorectal cancer (HNPCC) accounts for 2–3% of all colorectal cancers (CRC) and is characterized by mutations in DNA mismatch repair (MMR) genes. Colon cancer in HNPCC has been well- characterized, while rectal cancer (RC) has not. We describe the clinical characteristics in HNPCC patients (pts) with RC. Methods: Our institutional HNPCC Database was queried from February 1992 to January 2010 to identify pts with pathogenic MMR mutations (n=161), MMR variants of unknown significance (VUS) (n=33), tumor studies suggestive for MMR mutation but negative genetic testing (MMR TN) (n=44), and tumor studies suggestive for MMR mutation but no genetic testing (NT) (n=58). Of 296 pts, 195 pts (66%) were diagnosed with CRC. Group A pts had RC as the index CRC, whereas Group B pts had RC with synchronous or metachronous CRC. Results: Thirty-one (16%) of 195 CRC pts had RC: 23 pts in Group A and 8 pts in Group B. The median age of diagnosis of RC was 39 years (range 20–70) and 44.5 years (range 38–71) in the 2 groups, respectively. More pts in group A than Group B presented with stage III-IV RC (52% vs.12.5%). The revised Bethesda Guidelines identified more RC pts than the Amsterdam Criteria I/II (see Table). Twenty-two of 26 pts who underwent genetic testing had MMR gene abnormalities. MSH2 mutations were most common in both groups. Conclusions: Rectal cancer may be the index CRC in HNPCC and affected pts present at a young age with advanced disease. Most HNPCC pts with RC fit Bethesda Guidelines and had identifiable pathogenic MMR mutation, predominantly in MSH2. Investigation for HNPCC is warranted in pts with RC below age 50. Group AmsterdamCriteria I/II BethesdaGuidelines Gene Pathogenic MMR VUS MMR TN NT A (n=23) 10 (43%) 21 (91%) MLH1 4 0 1 3 MSH2 6 3 0 1 MSH6 2 0 1 0 PMS2 0 1 0 1 B (n=8) 3 (38%) 8 (100%) MLH1 0 1 0 0 MSH2 4 1 2 0 MSH6 0 0 0 0 PMS2 0 0 0 0 Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration LifeCell, Myriad Genetics Adolor/ GlaxoSmithKline, Genzyme
Lung-sparing intrapleural chemotherapy plus P32 radiation for pleural mesothelioma
Authors: R. N. Taub, J. R. Sonett, M. E. Ginsburg, R. Fawwaz, C. Visser, E. Hare, J. Leinwand, M. E. Hesdorffer
Journal: Journal of Clinical Oncology (2008)

7604 Background: Based on our experience using intracavitary chemotherapy for peritoneal mesothelioma we have given repeated outpatient courses of intrapleural (IP) chemotherapy plus IP radiation with P32 to selected patients with malignant pleural mesothelioma. Methods: Pts underwent initial videothoracoscopy (VATS) at which two IP catheters were placed, anteriorly from the ipsilateral lung apex along the pericardial border, and posteriorly into and along the diaphragmatic sulcus. Each catheter was attached to a subcutaneous mediport chamber. IP cisplatin 20–40 mg, doxorubicin 20 mg, or gamma interferon (1,000 micrograms) was injected into both ports to perfuse the entire pleural space, at 1–2 weekly intervals over 6–12 weeks. The distribution of injectate was verified by intracavitary iohexol CT imaging. Additional intravenous pemetrexed plus ciplatin chemotherapy was given to selected patients. At week 8–12 in suitable patients, the pleural cavity was imaged with radioactive Technetium-labelled sulfur colloid; if uniformly distributed, 15 mCi of radioactive p32 chromic phosphate sulfur colloid was injected, thereby delivering 4,000–6,000 cGy to accessible pleural surfaces. At a second-look VATS catheters were removed, and pleural surfaces inspected and biopsied. Results: 9 males and 3 female pts aged 46–79 were treated, five with both peritoneal and pleural involvement, others with unresectable disease or who refused surgery. 6 pts received IP P32. The above procedures were well tolerated without early or late complications. After up to two years of follow-up (as of Jan 2008) 3 patients show no overt disease at 18, 15, and 7 months. 4 patients have died, 3 of progressive pleural disease. 5 patients are alive with disease; one has undergone pleurectomy / decortication. Surgical pleurectomy / decortication or extrapleural pneumonectomy remain possible options in 4 other intracavitary-treated patients. Conclusions: This retrospective analysis allows the hypothesis that lung-sparing repeated intrapleural chemotherapy combined with intrapleural P32 radiotherapy may be safely used in patients with malignant pleural mesothelioma. This regimen deserves ongoing prospective study as to overall efficacy and potential incorporation into present day treatment paradigms. No significant financial relationships to disclose.
Ibrutinib and Rituximab Are an Efficacious and Safe Combination in Relapsed Mantle Cell Lymphoma: Preliminary Results from a Phase II Clinical Trial
Authors: Michael (Luhua) Wang, Fredrick Hagemeister, Jason R. Westin, Luis Fayad, Felipe Samaniego, Francesco Turturro, Wendy Chen, Liang Zhang, Maria Badillo, Maria DeLa Rosa, Alicia Addison, Larry W. Kwak, Jorge E. Romaguera
Journal: Blood (2014)
Abstract 028: Web-based Delivery with Food Portion Images Improves Dietary Assessment Results
Authors: Rick Weiss
Journal: Circulation (2012)

Introduction: Dietary assessment is achieved in a variety of ways, from written records and interviews to short questionnaires based on food categories, all with mixed success. Problems faced by the clinician are limited time for conducting assessments, time and resources required to evaluate collected information and lack of resources for supporting the change process. Due to their low cost and low participant burden, Food Frequency Questionnaires (FFQs) are the most practical method of dietary assessment but improvements are needed. Hypothesis: VioScreen, developed from a National Cancer Institute grant using a graphical method for dietary data collection and generating reports on nutrient intake and food use patterns will reliably assess intake making it suitable for clinical counseling and research. VioScreen’s web-based self-administered dietary habits questionnaire will provide an efficient and thorough assessment of dietary intake data. The tool: VioScreen is the only web-based, dietary assessment tool that includes 1,200 food images and portion size options. Results are immediately available for analysis by the researcher/clinician; an optional report can be produced for the participant that includes a food pattern analysis, a list of foods and nutrients consumed, and when used by a counselor generates tailored behavioral feedback. VioScreen uses the University of Minnesota’s Nutrition Coordinating Center database to ensure up-to-date food and nutrient information. Method: VioScreen was evaluated through an inter-method reliability study with 74 subjects conducted at The Ohio State University by comparing a baseline and 3 month FFQ to six 24-hour recalls conducted between the two FFQ’s. Average time for completing the FFQ was 26.7 +/− 10.0 minutes. Results: The inter-method reliability was higher for VioScreen than for the paper FFQ VioScreen was modeled after and higher than reported for many other paper FFQs used in major epidemiological studies. Of the macronutrients, only alcohol values were similar; for all others VioScreen correlations were substantially higher, being at or above 0.80 for most macronutrients (0.90 for alcohol, 0.84 for saturated fat, 0.82 for fat, and 0.79 for carbohydrate) and 0.67 for protein. Participant evaluations of VioScreen were generally very good to excellent on ease of use and capturing foods usually consumed. All subjects rated the questionnaire as easy to use, 93% rated VioScreen as either great or excellent, 99% would complete VioScreen if asked by a doctor and 95% thought pictures helped in selecting portion sizes. Conclusions: Use of multiple portion size pictures, incorporation of complex skip patterns, and elimination of missing or non-interpretable responses contributed to higher inter-method reliability.
A uthors' Response
Authors: Victor A. Drill
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Our conclusions differ from those reached in the British studies in two ways: (<i>a</i>) we may differ at some points in the interpretation of their data, and (<i>b</i>) for general conclusions, our reliance on direct studies conducted with the oral contraceptives. These have failed to demonstrate a relationship to the occurrence of thromboembolic disease, and if the conclusions of the British studies were generally correct we should have expected the increased risk to be apparent. Specific points are as follows: We agree that the specific rate reported by Dr. Vessey and Dr. Doll for idiopathic deep-vein thrombosis is, for various reasons, not comparable with the data which we quote. Achievement of their goal of obtaining direct comparability within their own study, between rates projected for users and nonusers, needs to be questioned carefully. As with all retrospective studies of this type, the population, for which the
Impact of age on outcomes of allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in elderly patients with acute myeloid leukemia
Authors: Jun Aoki, Heiwa Kanamori, Masatsugu Tanaka, Satoshi Yamasaki, Takahiro Fukuda, Hiroyasu Ogawa, Koji Iwato, Kazuteru Ohashi, Hirokazu Okumura, Makoto Onizuka, Yoshitomo Maesako, Takanori Teshima, Naoki Kobayashi, Yasuo Morishima, Makoto Hirokawa, Yoshiko Atsuta, Shingo Yano, Akiyoshi Takami
Journal: American Journal of Hematology (2015)

Previous studies have repeatedly reported that increasing age is a significant risk factor for worse outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) among patients with acute myeloid leukemia (AML). However, more recent studies reported conflicting results regarding the association between age and outcomes in elderly patients. Therefore, we conducted a large-scale, nationwide retrospective study to examine the impact of age on outcomes of allo-HSCT with reduced intensity conditioning (RIC) for AML patients who were older than 50 years. Of the 757 patients, 89 patients (11.8%) were 50-54, 249 patients (32.9%) were 55-59, 301 patients (39.8%) were 60-64 and 118 patients (15.6%) were ≥65 years old. The 3-year overall survival (OS) (47.8, 45.2, 37.9, and 36.6% for patients aged 50-54, 55-59, 60-64, and ≥65 years, respectively, P = 0.24) and nonrelapse mortality (NRM) (24.0, 22.8, 29.2, and 27.6% for patients aged 50-54, 55-59, 60-64, and ≥65 years, respectively, P = 0.49) were not significantly different among the four age groups. Multivariate analysis revealed that increased age had no significant effect on OS or NRM after adjusting for covariates. These results suggested that advanced patient age is not a contraindication for RIC allo-HSCT in elderly AML patients.
Abstract 3781: Identification Of AS160 As An Insulin, Ischemia, And Exercise Regulated Signaling Protein In The Heart
Authors: Ding An, Taro Toyoda, Eric B Taylor, Michael F Hirshman, Laurie J Goodyear
Journal: Circulation (2008)

The maintenance of glucose utilization is necessary for normal cardiac function, yet the distal signaling mechanisms mediating myocardial glucose uptake are not fully understood. Studies using adipocytes and skeletal muscle demonstrate that the Akt substrate of 160 kDa (AS160) is essential for GLUT4 translocation and glucose uptake. AS160 is a Rab GTPase-activating protein (GAP) containing 6 consensus Akt phosphorylation sites collectively referred to as “PAS” sites. Phosphorylation of PAS sites inactivates the GAP domain, resulting in GLUT4 translocation. Despite the importance of AS160 in glucose uptake, there have been no studies of AS160 in the heart. Using phosphoproteomics we identified a novel phosphorylation site, Ser 711 , which is an AMPK consensus sequence. We next determined if AS160 is phosphorylated on PAS and Ser 711 sites in response to 3 stimulators of glucose uptake in the heart, insulin (max dose, ip, 10 min), ischemia (global, 3 min), and exercise (treadmill running, 30 min). In addition, we used Akt2 knockout (KO) and AMPKα2 inactive transgenic mice (AMPKα2i TG) to assess upstream signaling to AS160. Insulin robustly increased AS160 PAS phosphorylation (450% above basal; p&lt;0.0001), an effect partially inhibited in Akt2KO mice (P&lt;0.05). Surprisingly, despite being an AMPK consensus sequence, insulin increased phosphorylation of Ser 711 (30%; P&lt;0.01), an increase abolished in Akt2KO mice. Neither ischemia nor exercise increased AS160 PAS phosphorylation. However, ischemia increased Ser 711 phosphorylation (70%; P&lt;0.01), an effect partially inhibited in AMPKα2i TG mice. Exercise slightly increased Ser 711 phosphorylation (20%; P&lt;0.02), which was abolished in AMPKα2i TG mice. To determine if a model of decreased cardiac glucose uptake has altered AS160 signaling, we used the db/db mouse and found a significant impairment in insulin-stimulated PAS and Ser 711 phosphorylation. In conclusion, this is the first report showing that insulin, ischemia, and exercise increase AS160 phosphorylation in the heart. These stimuli elicit distinct patterns of phosphorylation on PAS and the novel Ser 711 site. Akt2 and AMPKα2 are upstream signals mediating AS160 phosphorylation. AS160 is likely to be a critical signaling mechanism in the heart.