tbuckley/cabot-search huggingface dataset:
Tolerability and efficacy of modified FOLFIRINOX (mFOLFIRINOX) in patients with borderline-resectable pancreatic cancer (BRPC) and locally advanced unresectable pancreatic cancer (LAURPC).
Authors: Marlo A. Blazer, Christina Sing-Ying Wu, Richard M. Goldberg, Gary S. Phillips, Carl Richard Schmidt, Peter Muscarella, Samer S El-Dika, Jon P Walker, Somashekar Gopala Krishna, J. Royce Groce, Evan John Wuthrick, Terence M Williams, David Efries, Yahna T. Smith, Kris Mathey, Mandy Wagner, Josh Reardon, Edwin Christopher Ellison, Mark Bloomston, Tanios S. Bekaii-Saab
Journal: Journal of Clinical Oncology (2014)

275 Background: FOLFIRINOX exhibits a meaningful improvement in outcome measures in metastatic pancreatic cancer, making it an interesting regimen for BRPC and LAURPC. However, its use remains prohibitive due to toxicity. In this study, we examine the outcomes of mFOLFIRINOX as a neoadjuvant strategy for patients with BRPC and LAURPC. Methods: This is a retrospective analysis of a prospectively maintained database of patients who received mFOLFIRINOX for BRPC or LAURPC at Ohio State University. mFOLFIRINOX is as follows: irinotecan at 165 mg/m 2 ; oxaliplatin at 85 mg/m 2 ; 5-fluorouracil (5FU) at 2,400 mg/m 2 over 46 hours and pegfilgrastim on day 4 of each 2-week cycle. Cases were thoroughly reviewed by a multidisciplinary team prior to initiation of therapy and at each restaging scan. The primary outcomes of this analysis were resection rate and grade 3/4 (G3/4) toxicities. Results: Since 1/1/2011, 43 patients (20 BRPC; 23 LAURPC) have received mFOLFIRINOX. Patients received gemcitabine-based chemoradiation (36 Gy in 15 fractions) only if their best response was stable disease after 4 months of mFOLFIRINOX. At the time of this abstract, 39 patients are evaluable for primary outcome. Overall resection rate was 53.8% including 45% of patients with initially unresectable disease. R0 resection was achieved in 85.7% of the surgeries. See table for more results. The rate of G3/4 toxicity was remarkably low with no episodes of febrile neutropenia, G3/4 neutropenia or thrombocytopenia. Toxicities lead to dose reductions in 46% of patients. Conclusions: Neoadjuvant mFOLFIRINOX is an effective, well-tolerated regimen as part of an integrated, multimodality strategy in BRPC and LAURPC leading to high resection rates and high R0 resection frequency. [Table: see text]
Prognostic value of urinary N-telopeptide (uNTx) in patients (pts) with castration-resistant prostate cancer (CRPC) and bone metastases
Authors: S. Rajpar, A. Laplanche, E. Tournay, C. Massard, M. Gross-Goupil, K. Fizazi
Journal: Journal of Clinical Oncology (2008)

5138 Background: Several prognostic models predicting for survival have been developed in men with CRPC (J Clin Oncol 2002,20:3972–82, J Clin Oncol 2003,21:1232–7). In pts with bone metastases from CRPC not pretreated by a bisphosphonate, elevated uNTx level, a marker of bone resorption, predicts for skeletal-related events (SRE) (J Clin Oncol 2005, 23: 4925–35). We assessed the prognostic value of uNTx in a population of CRPC pts with bone metastases receiving zoledronic acid. Methods: From 2004 to 2007, 94 pts with bone metastases from CRPC receiving zoledronic acid for at least 2 months were prospectively screened for uNTx. The last zoledronic acid injection was given within 4 weeks before screening. Overall survival (OS) and SRE occurrence were evaluated and analysed by using the Cox regression model. Results: The median age was 66 (46–88) years. Median PSA was 66 ng/ml (0–3984) and median uNTx was 19 nmol/mmol creatinine (3–489). 38 patients (40%) presented an SRE. Censoring death, the median time to SRE was 29 months. The median (95% CI) OS was 20 months (15–24). In univariate analysis, uNTx > 20 nmol/mmol creatinine (p<0.0001), poor performance status (p<0.001), PSA > 70 ng/ml (p<0.001), haemoglobin < 12 g/dL (p<0.002), and elevated alkaline phosphatase (p<0.001) were significantly associated with OS. In multivariate analysis, elevated uNTx (HR [95%CI]: 2.2 [1.2–4.0]) and PSA (HR [95%CI]: 2.8 [1.6–5.1]) were independent prognostic factors of OS. The median OS was 12 months (10–16) and 25 months (21–34) in pts with uNTx > 20 nmol/mmol creatinine and in those with uNTx < 20 nmol/mmol creatinine, respectively. A nomogram integrating uNTx together with other known prognostic factors was developed. Conclusion: An elevated uNTx level is a strong and independent prognostic factor of OS in pts with bone metastases from CRPC. No significant financial relationships to disclose.
Death of Bystander Cells by a Novel Pathway Involving Early Mitochondrial Damage in Human Immunodeficiency Virus–Related Lymphadenopathy
Authors: Maurizio Carbonari, Anna Maria Pesce, Marina Cibati, Alessandro Modica, Lucia Dell'Anna, Giampiero D'Offizi, Alberto Angelici, Stefania Uccini, Andrea Modesti, Massimo Fiorilli
Journal: Blood (1997)
An estimation of the incidence of tuberous sclerosis complex in a nationwide retrospective cohort study (1997–2010)
Authors: C.‐H. Hong, H.‐P. Tu, J.‐R. Lin, C.‐H. Lee
Journal: British Journal of Dermatology (2016)

Tuberous sclerosis complex (TSC) is caused by mutations in TSC1 and TSC2, leading to mammalian target of rapamycin hyperactivation. Patients with TSC develop hamartomas in brain, lungs, liver and skin. Two epidemiological studies, performed in Minnesota, U.S.A., have estimated the incidence of TSC to be 0·28-0·56 per 100 000 person-years (PY), based on < 12 patients. Furthermore, whether common comorbidities are associated with this rare disease is not known.To estimate the incidence of TSC and investigate the associations of TSC with other comorbidities, including diabetes, peptic ulcers, stroke and myocardial infarction.We estimated the incidence and prevalence of TSC and its comorbidities from 1997 to 2010, based on the Catastrophic Illness Certificate disease database and a beneficiary cohort of 1 million people.The incidence of TSC in Taiwan is 0·153 per 100 000 PY. The number of patients identified with TSC in Taiwan doubled from 206 in 2006 to 471 in 2010. In 2010, the prevalence of TSC in Taiwan was estimated to be 1·58 in 100 000. We confirmed that female patients with TSC are more likely to develop renal tumours than male patients. Surprisingly, patients with TSC have a significantly decreased risk of developing peptic ulcers compared with controls.This is the first large-scale and longitudinal incidence study of TSC. This study provides compelling evidence that TSC mutations in humans are associated with a decreased risk of peptic ulcers.
Acute vasomotor response--a reaction to etoposide.
Authors: A E Athanassiou, D Bafaloukos, D Pectasidis, M Dimitriadis
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.7.1204 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3079542 Acute vasomotor response--a reaction to etoposide. A E AthanassiouxA E AthanassiouSearch for articles by this author , D BafaloukosxD BafaloukosSearch for articles by this author , D PectasidisxD PectasidisSearch for articles by this author , M DimitriadisxM DimitriadisSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.7.1204 PDF "Acute vasomotor response--a reaction to etoposide.." Journal of Clinical Oncology, 6(7), pp. 1204–1205© 1988 by American Society of Clinical Oncology
Complementarity and redundancy of IL-22-producing innate lymphoid cells
Authors: Lucille C Rankin, Mathilde J H Girard-Madoux, Cyril Seillet, Lisa A Mielke, Yann Kerdiles, Aurore Fenis, Elisabeth Wieduwild, Tracy Putoczki, Stanislas Mondot, Olivier Lantz, Dieter Demon, Anthony T Papenfuss, Gordon K Smyth, Mohamed Lamkanfi, Sebastian Carotta, Jean-Christophe Renauld, Wei Shi, Sabrina Carpentier, Tim Soos, Christopher Arendt, Sophie Ugolini, Nicholas D Huntington, Gabrielle T Belz, Eric Vivier
Journal: Nature Immunology (2015)
<i>Notes from the Field</i>: Subacute Sclerosing Panencephalitis Death — Oregon, 2015
Authors: Juventila Liko, Judith A. Guzman-Cottrill, Paul R. Cieslak
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In 2015, the Oregon Health Authority was notified of the death of a boy with subacute sclerosing panencephalitis (SSPE), a rare and fatal complication of measles. The patient, aged 14 years, had reportedly been vaccinated against measles in the Philippines at age 8 months. However, the patient contracted measles at age 1 year while still in the Philippines. He had been well until 2012, when his neurodegenerative symptoms began. After the diagnosis of SSPE was made, the patient remained in home hospice care until his death. Investigators from the Oregon Health Authority and the Oregon Health and Science University reviewed the patient's medical records and interviewed the parents. Vaccination against measles can prevent not only acute measles and its complications, but also SSPE.
Abstract 297: Paroxysmal And Sustained Atrial Fibrillation In A New Large Animal Model Of Nonischemic Heart Failure
Authors: Saad Sikanderkhel, Olawale Onibile, Gregory P Walcott, Steven M Pogwizd
Journal: Circulation Research (2014)

Introduction: Atrial fibrillation is common in heart failure (HF). Understanding of the mechanisms of atrial fibrillation (AF) is limited by the paucity of large animal AF models, especially in the failing heart. We developed a large animal model of nonischemic heart failure (HF) in dogs by combined aortic insufficiency and aortic constriction and observed that a number of HF dogs developed paroxysmal AF on holter monitor. Here we characterize the spontaneously-occurring pAF in these HF dogs and perform electrophysiologic (EP) assessment of atrial refractoriness and AF inducibility along with echocardiographic imaging of left ventricle (LV) and left atrium (LA). Methods: HF was induced in dogs by aortic insufficiency and aortic constriction, and serial echocardiography (for LV fractional shortening (FS) and LA size) and Holter monitoring was performed. In control and HF dogs, EP study of atrial refractory period (AERP) and AF inducibility (duration and atrial cycle length (CL)) was performed. Results: By Holter monitoring, paroxysmal AF was noted in 5 dogs with episodes ranging from 15 to 94 beats long (mean of 49±27 beats, n=12). In EP studies, control dogs (N=3) exhibited AERP of 176±8 ms. Burst pacing resulted in AF of very brief duration (mean 32±24 sec) and a mean AF CL of 138±6 ms. LV FS averaged 37% and LA size averaged 4.3 cm2. HF dogs (N=5) exhibited RAERP of 150±8 (p=0.05 vs control). Two of these dogs had sustained AF with ventricular response up to 230 bpm on Holter monitor. In the other 3 HF dogs, burst pacing induced AF with a mean duration of 232±185 sec (at times with conversion to atrial flutter) and with a mean AF CL = 110±4 ms (p=0.002 vs control). Echo data showed LVFS averaged 30% and LA area of 14.9 cm2 (p=0.05 vs control). Conclusion: Thus we have developed a novel large animal model of HF that exhibits paroxysmal and sustained AF. This model will provide an opportunity for the study of underlying AF mechanisms, the progression of remodeling in HF hearts leading to AF, and the assessment of human-scale interventions to better treat and prevent this arrhythmia.
Analyse of the MEFV curve in preschool children by measurement of expiratory volume in the course of expiratory flow
Authors: Valerie Siao, Julie Mulliez, Xavier Drouot, Michel Eugene, Veronique Diaz
Journal: European Respiratory Journal (2014)

In preschool children, a reliable performance of spirometry is rarely be obtained by standard lung function test. The airway obstruction is evaluated with the measurement of respiratory system resistance by interruption and impulse oscillation test. Nevertheless, maximum expiratory flow volume (MEFV) curves offer more information on airway caliber than resistance measurements. The aim of our study was to analyse the MEFV curve in preschool children with and without airway obstruction by measuring the expiratory volume in the course of expiratory flow and to compare standard forced expiratory test ( FEV1, MEF25, MEF50, MEF75) with expiratoy volume (Vexp30, Vexp60, Vexp90) at 30%, 60% and 90% of PEF.  Primary, retrospectively, we analysed Vexp 30, Vexp60 and Vexp90 in asthmatic and control school aged children. Then, we compared Vexp and resistance measurement by interruption in asthmatic and control preschool children.  In the retrospective part of the study, 26 asthmatic school-aged children and 32 control were included. Vexp 30, Vexp60 and Vexp90 were significantly lower in the asthmatic group (p  Airway obstruction evaluation is very important in asthma management of the preschool children: it is predictive of the severity of asthma and predictive of lung function in adulthood. We will compare the Vexp in healthy and asthmatic preschool children in a largest study to obtain reference values.
A mastectomy--how so? An etymologic plea.
Authors: R W MacMillan, J E Olson
Journal: Journal of Clinical Oncology (1986)

The word mastectomy and its modifiers are used so loosely and have so many meanings in the literature that it is often difficult to determine precisely what procedure the authors are discussing. Simple descriptive terms should be used that would standardize the terminology with respect to operative techniques. The classical term radical mastectomy should be reserved to refer to a complete en bloc resection of the breast with the pectoralis major and minor muscles and the entire axillary contents, with or without a skin graft for wound closure. A total mastectomy should indicate a complete resection of the breast, including the fascia of the pectoralis major muscle. A local excision should be defined as a resection of the primary tumor with margins that are free of disease, with specific margins stated if desired. The axillary lymph node dissection should be defined according to the extent of the axillary contents excised.
O049 : Serum lipidomic profiling for screening potential biomarkers of hepatocellular carcinoma by ultraperformance liquid chromatography-mass spectrometry
Authors: A.M. Passos-Castilho, V.M. Carvalho, K.H.M. Cardozo, L. Kikuchi, A. Chagas, J.R. Pinho, M.S. Gomes-Gouvêa, F. Malta, F.J. Carrilho, C.F.H. Granato
Journal: Journal of Hepatology (2015)
Abstract 277: Neurologically Intact Survival and Time Interval From Collapse to Return of Spontaneous Circulation for Out-of-Hospital Non-Shockable Cardiac Arrest; A Comparison of Pulseless Electrical Activity and Asystole
Authors: Ken Nagao, Asuka Kasai, Eizo Tachibana, Naohiro Yonemoto, Morimasa Takayama, Hiroshi Nonogi, Shinichi Shirai, Takeshi Kimura
Journal: Circulation (2013)

Background: Early achievement of return of spontaneous circulation (ROSC) after cardiac arrest is critical to neurologically intact survival, but few data are available concerning this interval comparing pulseless electrical activity (PEA) and asystole. Methods: From the All-Japan Utstein Registry, a prospective, nationwide, population-based registry of out-of-hospital cardiac arrest (OHCA) between 2005 and 2011, we included adult patients who received resuscitation care after witnessed OHCA due to non-shockable arrest and whose ROSC was achieved before hospital arrival. We divided study patients into two groups according to the initial cardiac arrest rhythm and evaluated the relationship between the collapse-to-ROSC interval and favorable neurological outcome 30 days after cardiac arrest. Results: Of the 31,845 patients who achieved ROSC after witnessed OHCA, 12,905 (40.8%) achieved ROSC after PEA and 7,259 (22.8%) after asystole. The PEA group had a significantly shorter collapse-to-ROSC interval compared with the asystole group (18.9±11.6 vs. 25.3±12.6 minutes, p&lt;0.0001) and a significantly higher frequency of 30-day favorable neurological outcome (15.5% vs. 7.1%, p&lt;0.0001). After adjustment for resuscitation, the likelihood of favorable neurological outcome decreased for every 1 minute increment in the collapse-to-ROSC interval in the PEA group (adjusted OR; 0.94, 95% CI, 0.93 to 0.95) and in the asystole group (adjusted OR; 0.93, 95% CI, 0.91 to 0.94). Non-linear regression analysis showed that frequency of favorable neurological outcome decreased from 33.6% to 0% for every minute that passed between collapse and ROSC in the PEA group and from 29.2% to 0% in the asystole group. For favorable neurological outcome, a collapse-to-ROSC interval of 56.5 minutes had a sensitivity of 100% with a negative predictive value of 99.6% in the PEA group, and that of 56.5 minutes had a sensitivity of 100% with a negative predictive value of 99.1% in the asystole group. Conclusion: In patients achieving ROSC after witnessed OHCA, PEA patients had a significantly higher favorable neurological outcome than asystole patients. However, the interval in which resuscitation efforts must be sustained is similar for both arrest rhythms.
Early Detection of Hereditary Renal Cell Cancer By Improved Evaluation of Spontaneous Pneumothorax Patients
Authors: P.C. Johannesma, A.C. Houweling, R. Reinhard, E. Thunnissen, F. Menko, J.H.T. van Waesberghe, M.A. Paul, S. Horenblas, P.E. Postmus, R.J.A. van Moorselaar
Journal: Annals of Oncology (2014)
Correlation of the Karnofsky performance status (KPS) with nutritional status as measured by the Scored Patient-generated Subjective Global Assessment (PG-SGA) in patients with advanced cancer in palliative treatment
Authors: F. Bortolon, E. R. Goldberg, D. L. da Silva, A. P. Loureiro, A. F. Ferreira Filho
Journal: Journal of Clinical Oncology (2008)

20709 Background: The incidence of malnutrition amongst patients with cancer is estimated at between 40 and 80%. Prompt detection of nutritional compromise is critical to initiate early nutritional and/or pharmacological interventions with the aim to improve the quality- of-life of cancer patients. The PG-SGA is a simple, reliable and inexpensive screening tool that uses clinical data to detect mild or moderate malnutrition before the patient becomes overly wasted. Our main objective was to characterize the nutritional status of patients with advanced cancer receiving palliative care, as measured by the PG-SGA and correlate its results with the KPS of this patient cohort. Methods: We evaluated the PG-SGA and the KPS of 74 patients with advanced stage cancer in palliative treatment. Results: Patients were aged 24–81 years (median 57 years). Forty-two patients were women (55%), and 30 of the patients (40%) were hospitalized. The most common neoplasms were: lung 39%, colorectal 18% and breast 10%. The main symptoms negatively affecting oral intake were: anorexia 70%, early satiety 62%, pain 57%, xerostomia 53%, altered smell and taste 40%, constipation 33%, dysphagia 31% and nausea 28%. According to the PG-SGA, 48% (36) were moderately or suspected of being malnourished, 30 (22%) of patients were severely malnourished and 22% (13) of patients were well-nourished. There was a significant difference in the median PG-SGA scores for each of the SGA classifications (P<0.001), with the severely malnourished patients having the highest scores. The functional capacity, as evaluated by the KPS, demonstrated that 36 (49%) scored between 50–70%, 26 (35%) between 10–40% and 12 patients (16%) between 80–100%. The median KPS was 50%. There was a statistically significant correlation between the scored PG-SGA and the KPS (r = −0.63, p<0.001). Conclusions: The ASG-PPP score and the KPS are highly correlated in patients with advanced cancer, supporting the concept that the KPS is an important and informative variable in the evaluation of the nutritional status in these patients. The nature of this correlation and its clinical implications need to be further investigated. No significant financial relationships to disclose.
Targeting an embryonic signaling pathway to suppress the metastatic phenotype
Authors: Mary J.C. Hendrix, Elisabeth A. Seftor, Postovit Lynne-Marie, Naira V. Margaryan, Hardy Katharine, Seftor E.B. Richard, Dawn A. Kirschmann, Fabricio F. Costa, Jared M. Bischof, de Fatima Bonaldo Maria, Marcelo B. Soares, Luigi Strizzi
Journal: Clinical Cancer Research (2010)

Abstract The diagnosis of melanoma is becoming more frequent. Although surgical excision of early lesions is associated with relatively significant high cure rates, treatment modalities are largely unsuccessful for advanced disease. Characteristics such as cellular heterogeneity, phenotypic plasticity and the expression of embryonic related molecules and signaling pathways that are important for self renewal and pluripotency, present a challenge in targeting the most aggressive tumor cells. However, the absence of major regulatory checkpoints in these tumor cells allows aberrant activation of embryonic signaling pathways. In particular, the embryonic morphogen Nodal, belonging to the TGF-β superfamily, is an important regulator of embryonic stem cell fate. We have recently demonstrated that Nodal is also expressed in aggressive melanoma, although unlike embryonic stem cells, melanoma does not express Lefty, a natural inhibitor of Nodal, thus allowing Nodal to be expressed in an unregulated manner. Further analysis revealed that Lefty is silenced in these tumor cells by DNA methylation. Down-regulation of Nodal expression in melanoma cells results in a significant reduction in clonogenicity and suppression of tumorigenesis. Additional translational studies indicate that antibodies against Nodal are capable of targeting and inducing apoptosis in human melanoma tumors lodged in the lungs of nude mice. Furthermore, our data show another stem cell signaling pathway, Notch, is expressed in these aggressive melanoma cells, and there is direct evidence demonstrating the molecular cross-talk between Nodal and Notch. Thus, these two prominent stem cell pathways contributing to melanoma cell plasticity may serve as promising dual therapeutic targets for clinical intervention.