tbuckley/cabot-search huggingface dataset:
The spiritual needs assessment for patients survey (SNAPS): Translation into Chinese and and psychometric testing.
Authors: A. B. Astrow, S. Wang, Y. Huang, Y. Xu, J. Weedon, D. Sulmasy
Journal: Journal of Clinical Oncology (2011)

e19589 Background: Previous research has focused on the relationship between spiritual and religious attitudes and health outcomes. Little has been done to assess patients’ spiritual needs, especially among Asian immigrants. We report on a new Chinese translation of our previously validated 23-item scale to assess patients’ spiritual needs (J Gen Intern Med 2009 24 (S1): S194-5). Methods: A bilingual Chinese-American MD translated the SNAPS questionnaire, which was then revised after review by a focus group of 8 bilingual staff (7 Mandarin, 3 Cantonese). Further revisions followed back translation by an independent bilingual individual and cognitive pre-testing with 8 Chinese cancer patients. We then administered SNAPS to a convenience sample of 30 Chinese patients at the Maimonides Cancer Center. We assessed test/re-test reliability and Cronbach's α, and correlated scores with response to the question, “Are your spiritual needs being met?” Results: Mean age 56; 63% with no religious belief; 83% self-described as spiritual but not religious; 70% no high school education; 77% with Medicaid. Overall Cronbach α was 0.89. The α for the psychospiritual subscale (5 items, eg, “relaxation or stress management, etc”) = 0.58 with test/re-test correlation 0.57; spiritual subscale (13 items, eg, “Finding meaning in your experience of illness, etc”) = 0.83 with test/-re-test correlation 0.70; religious subscale (5 items, eg, “Visit from chaplain, etc.”) = 0.91 with test/re-test correlation 0.77. All three subscales showed moderately high needs (psychospiritual: mean = 13.7±3.5 out of 20; spiritual: 28.5±8.8 out of 52; religious: 8.3±4.4 out of 20, with higher scores indicating greater needs). In contrast to the English instrument, there was no correlation between a higher score on the spiritual needs subscale and negative response to the question, “Are your spiritual needs being met?” (p = 0.38). Conclusions: The Chinese SNAPS is reliabile and internally consistent. Lack of correlation between SNAPS scores and the “spiritual needs” item suggests that our instrument may capture patient needs that Chinese patients would not readily describe as spiritual, whether due to cultural differences or educational level.
Abstract 11735: Effects of Pioglitazone versus Glimepiride on Abdominal Fat Glucose Metabolism in Patients with Impaired Glucose Tolerance and/or Type 2 Diabetes Mellitus
Authors: Norihiro Kodama
Journal: Circulation (2012)

OBJECTIVE Visceral fat is associated with cardiovascular morbidity and mortality. It was reported that pioglitazone decreased, increased, or unchanged visceral fat volume. It is unknown that piogli...
Diagnosis of adult psychiatric patients with childhood hyperactivity
Authors: J R Morrison
Journal: American Journal of Psychiatry (1979)

The authors compared 48 adult psychiatric patients (27 men and 21 women) who had been hyperactive as children with two groups of patients who had not. Both comparison groups were matched for age and sex and the second was also matched for economic status. Although closer matching narrowed the gap somewhat, the formerly hyperactive subjects still showed significantly more personality disorder of all types, more sociopathy, more alcoholism, and less affective disorder than controls. Schizophrenia and drug abuse occurred no more often in these subjects than in the comparison groups.
Discrimination of Human Small Cell and Non-Small Cell Lung Tumors by a Panel of Monoclonal Antibodies&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: A W Tong, J C Lee, M J Stone
Journal: JNCI Journal of the National Cancer Institute (1986)

The immunohistochemical reactivity of biopsy specimens from different human lung tumor cell types was examined with 4 human small cell lung carcinoma (SCLC)-reactive monoclonal antibodies (MoAbs) (SCLC 1096, SCLC 2051, SCLC 3121, and SCLC 5023) generated in this laboratory, with the use of Formalin-fixed, paraffin-embedded tissue sections. Each MoAb reacted preferentially with SCLC tumors (62-97% of 29 cases tested), with low-to-moderate cross-reactivity with non-SCLC tumors (SCLC 1096, 13.7%; SCLC 2051 and SCLC 3121, 9.8% each; SCLC 5023, 41%, of 51 cases tested). None of the 4 MoAbs reacted with nonmalignant lung biopsy specimens. SCLC tumors were characterized by their collective immunoperoxidase reactivity with the MoAb panel of SCLC 2051, SCLC 3121, and SCLC 5023. Based on unequivocal positive reactions with at least 2 of the 3 MoAbs, this MoAb panel correctly identified 97% (28/29) of SCLC cases of 80 lung tumor cases tested. By contrast, only 4 of 51 (7.8%) non-SCLC cases were positive by the same criterion. These observations suggest that immunohistochemical analysis with these SCLC-reactive MoAbs could help in discriminating small cell from other human lung carcinoma cell types.
Premenstrual mood disorder and psychiatric illness
Authors: R DeJong, D R Rubinow, P Roy-Byrne, M C Hoban, G N Grover, R M Post
Journal: American Journal of Psychiatry (1985)

The results of several studies suggest that a special relationship exists between premenstrual syndromes and major psychiatric disorders, particularly affective illness. These studies in general have not employed prospective criteria to diagnose premenstrual syndrome. In this paper the authors report a significant difference in the lifetime history of psychiatric illness between women with prospectively confirmed menstrually related mood disorder and those without it.
Early Experience of Intraoperative Autotransfusion
Authors: A J Wilson, B J Cuddigan, A P Wyatt
Journal: Journal of the Royal Society of Medicine (1988)

Intraoperative autotransfusion of whole blood was performed using the Solcotrans device in 45 patients undergoing major vascular surgery or other procedures in which there was a clean operative field. Overall, 60% of the blood shed during these operations was reinfused. Approximately 50% of patients avoided the potential complications of homologous transfusion. There were no complications attributable to the use of this device although in a sample of 13 patients, 30% of the erythrocytes were haemolysed and there were other minor haematological abnormalities. In conclusion this device provides a simple method of autotransfusing 2 or 3 litres of blood aspirated from an uncontaminated operative field.
Experience in QT evaluation of oncology drug products since ICH E14 guidance
Authors: Q. Liu, R. Madabushi, C. Garnett, B. Booth
Journal: Journal of Clinical Oncology (2008)

2554 Background: The objective of a ‘thorough QT (TQT) study’ is to determine whether a drug at supratherapeutic concentrations has a pharmacological effect on cardiac repolarization as detected by QT/QTc prolongation. The design is a randomized, (preferably) double-blinded, placebo- and positive-controlled study typically conducted in healthy male and female volunteers. There are several challenges with implementing a TQT study for oncology drug products: toxicities preclude administering the drug at supratherapeutic concentrations to cancer patients or to healthy volunteers and it is not feasible to administer the positive control to cancer patients. Methods: NDAs submitted during 2006–2007 were reviewed for QT evaluation. The study design, analysis methods and labeling implications were compared across submissions. Lapatinib submission was used as a case study. Results: Nine original NDAs were submitted of which five have been approved, three are under-review and one was withdrawn. Seven (78%) of the submissions contained QT evaluation from phase 1/2 studies. Of the submissions with QT data, two submissions contained a dedicated QT study but these studies did not meet the criteria of a TQT study defined by ICH E14. Time-matched concentrations and ECGs were available in six (85%) of the seven submissions. Concentration-QT analysis was performed in all six submissions by FDA reviewers. Of the five approved submissions, four were found to prolong the QT interval and labeled accordingly. The lapatinib case study underlines the need for collecting useful and interpretable data when using alternative designs. Conclusions: It is important to assess QT prolongation of oncology drug products. A TQT should be conducted if the drug can be administered to healthy subjects or placebo controls can be used in patients. Alternative designs can be used to evaluate QT when TQT study cannot be conducted. However, strategic planning of the alternate designs early in development will aid in collecting useful, interpretable data. Studies employing time-matched baseline ECGs and time-matched concentrations are essential for assessing drug effects on QT interval when employing alternate designs. No significant financial relationships to disclose.
Real-world risk score for hepatocellular carcinoma (RWS-HCC): a clinically practical risk predictor for HCC in chronic hepatitis B
Authors: Zhongxian Poh, Liang Shen, Hwai-I Yang, Wai-Kay Seto, Vincent W Wong, Clement Y Lin, Boon-Bee George Goh, Pik-Eu Jason Chang, Henry Lik-Yuen Chan, Man-Fung Yuen, Chien-Jen Chen, Chee-Kiat Tan
Journal: Gut (2016)

We read with great interest the recent paper by Abu-Amara et al 1 showing that hepatocellular carcinoma (HCC) risk scores derived from Asian cohorts with chronic hepatitis B (CHB) were applicable to a heterogeneous North American patient population as well. They reported that the scoring systems were especially accurate in identifying low-risk patients and as such it is reasonable to use them to guide HCC surveillance recommendations. Out of the five risk scores evaluated, the Chinese University (CU)-HCC and Guide with Age, Gender, HBV DNA, Core promoter mutations and Cirrhosis (GAG-HCC) performed the best.2 ,3 However, HBV DNA titres are needed in both scores and additionally, core mutation determination is needed for even better prediction in the GAG-HCC. Liu et al 4 showed that HBsAg titre is useful in stratifying HCC risk in non-viraemic patients and a recent risk score published by Lin et al 5 included HBsAg titre. These are costly tests that are not universally available.

We have …
Coffee and Pancreatic Cancer (Chapter 2)
Authors: J Mohle-Boetani, S Grosser, M Malec, A S Whittemore
Journal: New England Journal of Medicine (1986)

A letter to the editor presents and discusses supplementary data developed in a multi-year case-control study of the possible association between coffee intake and pancreatic cancer risk. Data are presented on the differences in daily coffee consumption between sexes in patients and controls 10 years before diagnosis, and on the differences in total cumulative cups of regular, decaffeinated, and all types of coffee consumed by patients and controls. Estimates of risk ratios as a function of coffee intake are presented with both of these data sets. Although there was a slight increase in risk associated with the heaviest coffee consumption, no differences in risks were found between sexes at any coffee intake level. Furthermore, no significant difference in risk was found between consumption of regular vs. decaffeinated coffee, suggesting the lack of correlation between coffee consumption and pancreatic cancer risk. Hence, the findings of this study do not support earlier reports of such a correlation.(wz)
Transmission Electron Microscopy of Fetal Rat Brain Cells During Neoplastic Transformation in Cell Culture&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: A Haugen, O D Laerum
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Transmission Electron Microscopy of Fetal Rat Brain Cells During Neoplastic Transformation in Cell Culture Get access Åge Haugen, Åge Haugen Search for other works by this author on: Oxford Academic PubMed Google Scholar Ole Didrik Laerum Ole Didrik Laerum Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 63, Issue 2, August 1979, Pages 455–464, https://doi.org/10.1093/jnci/63.2.455 Published: 01 August 1979 Article history Received: 05 September 1978 Accepted: 23 January 1979 Published: 01 August 1979
Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease
Authors: Nathan D Mathewson, Robert Jenq, Anna V Mathew, Mark Koenigsknecht, Alan Hanash, Tomomi Toubai, Katherine Oravecz-Wilson, Shin-Rong Wu, Yaping Sun, Corinne Rossi, Hideaki Fujiwara, Jaeman Byun, Yusuke Shono, Caroline Lindemans, Marco Calafiore, Thomas M Schmidt, Kenya Honda, Vincent B Young, Subramaniam Pennathur, Marcel van den Brink, Pavan Reddy
Journal: Nature Immunology (2016)
Lack of Pathogenicity of Marek's Disease Virus and Herpesvirus of Turkeys in Marmoset Monkeys
Authors: J M Sharma, R L Witter, G Shramek, L G Wolfe, B R Burmester, F Deinhardt
Journal: JNCI Journal of the National Cancer Institute (1972)

Newborn, juvenile, and adult marmosets were inoculated with Marek's disease virus (MDV) and herpesvirus of turkeys (HVT) and observed for 1 year or longer. No clinical signs of disease attributable to the inocula were seen. Routine hematologic surveys and liver biopsies showed no abnormalities. None of the treated marmosets was viremic when tested approximately 4 weeks post inoculation. Sera from 1 of 34 marmosets inoculated with HVT and 2 of 29 marmosets given MDV reacted against HVT or MDV in an immunofluorescence (IF) test; however, preinoculation sera from 2 of the 3 reactor marmosets were also positive by the IF test. The specificity of the serologic reactions remained equivocal and could not be confirmed by virus neutralization tests. Attempts to replicate MDV and HVT in cell cultures of marmoset kidney, marmoset skin and muscle, human embryonic kidney, and WI-38 cells with or without diethylaminoethyldextran treatment or cocultivated with X-irradiated MDV- or HVT-infected duck embryo fibroblasts cells with or without the addition of ultraviolet-irradiated Sendai virus were unsuccessful.—J Natl Cancer Inst 49: 1191–1197, 1972.
<i>Evening</i>
Authors: Jeanette M. Smith
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sensitivity of Renal Cell Cancer to Nonmyeloablative Allogeneic Hematopoietic Cell Transplantations: Unusual or Unusually Important?
Authors: Frederick R. Appelbaum, Brenda Sandmaier
Journal: Journal of Clinical Oncology (2002)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.8.1965 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11956252 Sensitivity of Renal Cell Cancer to Nonmyeloablative Allogeneic Hematopoietic Cell Transplantations: Unusual or Unusually Important? Frederick R. AppelbaumxFrederick R. AppelbaumSearch for articles by this author , Brenda SandmaierxBrenda SandmaierSearch for articles by this author Show More Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA https://doi.org/10.1200/JCO.2002.20.8.1965 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers
Authors: Yael Strulovici-Barel, Renat Shaykhiev, Jacqueline Salit, Ruba S. Deeb, Anja Krause, Robert J. Kaner, Thomas L. Vincent, Francisco Agosto-Perez, Guoqing Wang, Charleen Hollmann, Vignesh Shanmugam, Ahmad M. Almulla, Hisham Sattar, Mai Mahmoud, Jason G. Mezey, Steven S. Gross, Michelle R. Staudt, Matthew S. Walters, Ronald G. Crystal
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Rationale: Waterpipes, also called hookahs, are currently used by millions of people worldwide. Despite the increasing use of waterpipe smoking, there is limited data on the health effects of waterpipe smoking and there are no federal regulations regarding its use.Objectives: To assess the effects of waterpipe smoking on the human lung using clinical and biological parameters in young, light-use waterpipe smokers.Methods: We assessed young, light-use, waterpipe-only smokers in comparison with lifelong nonsmokers using clinical parameters of cough and sputum scores, lung function, and chest high-resolution computed tomography as well as biological parameters of lung epithelial lining fluid metabolome, small airway epithelial (SAE) cell differential and transcriptome, alveolar macrophage transcriptome, and plasma apoptotic endothelial cell microparticles.Measurements and Main Results: Compared with nonsmokers, waterpipe smokers had more cough and sputum as well as a lower lung diffusing capacity, abnormal epithelial lining fluid metabolome profile, increased proportions of SAE secretory and intermediate cells, reduced proportions of SAE ciliated and basal cells, markedly abnormal SAE and alveolar macrophage transcriptomes, and elevated levels of apoptotic endothelial cell microparticles.Conclusions: Young, light-use, waterpipe-only smokers have a variety of abnormalities in multiple lung-related biological and clinical parameters, suggesting that even limited waterpipe use has broad consequences on human lung biology and health. We suggest that large epidemiological studies should be initiated to investigate the harmful effects of waterpipe smoking.
Risk factors for in-hospital mortality and prolonged length of stay in older patients with solid tumors
Authors: M. Shayne, E. Culakova, M. S. Poniewierski, D. A. Wolff, G. H. Lyman
Journal: Journal of Clinical Oncology (2009)

9550 Background: Little is known about risk factors that contribute to prolonged hospitalization and mortality in older patients with cancer. Methods: Cancer patients ≥65 years of age hospitalized between 1995 and 2003 at 133 academic medical centers were evaluated using the University Health System Consortium discharge database. This study identified 386,377 older hospitalized patients with various solid tumors. Multivariate analyses were performed to determine variables independently associated with the primary endpoints: length of stay (LOS) ≥10 days and in-hospital mortality (IHM). Results: Average LOS was 7.5 days with 23% hospitalized ≥10 days. A significant improvement in LOS was observed over the study timeframe (p&lt;.0001). Patients with gastric cancer had the greatest risk of prolonged LOS while those with breast cancer had the lowest risk. Additional risk factors for prolonged LOS included infection, venous thromboembolism and red blood cell transfusion (RBCT). The overall rate of IHM was 7.3% with a significant improvement in risk over the study timeframe (p&lt;.0001). IHM was strongly associated with prolonged LOS (p&lt;.0001). Older patients with primary central nervous system malignancies had the highest rates of IHM (OR=1.81; 95% CI: 1.59–2.07), followed by esophageal and lung cancer. Male gender was a risk factor for both IHM and prolonged LOS (p&lt;.0001). Older African American cancer patients were more likely to experience prolonged LOS and IHM compared with Caucasian patients (p&lt;.0001) after adjustment for cancer type and comorbidities. Additional risk factors associated with IHM included metastatic disease, active infection, neutropenia, renal disease, lung disease, arterial and venous thromboembolism, congestive heart failure, hepatic disease, and RBCT. Conclusions: Improving trends in LOS and IHM for older patients with solid tumors were observed over time in this study. Risk factors associated with IHM such as infection, neutropenia and RBCT, when modified, could potentially further reduce rates of prolonged LOS and IHM in older cancer patients. [Table: see text]
Targeting MIF in Cancer: Therapeutic Strategies, Current Developments, and Future Opportunities
Authors: Ciaran O'Reilly, Mohammad Doroudian, Leona Mawhinney, Seamas C. Donnelly
Journal: Medicinal Research Reviews (2016)

Abstract Strong evidence has been presented linking chronic inflammation to the onset and pathogenesis of cancer. The multifunctional pro‐inflammatory protein macrophage migration inhibitory factor (MIF) occupies a central role in the inflammatory pathway and has been implicated in the tumorigenesis, angiogenesis, and metastasis of many cancer phenotypes. This review highlights the current state of the art, which presents MIF, and the second member of the MIF structural superfamily, d ‐DT (MIF2), as significant mediators in the inflammatory–cancer axis. Although the mechanism by which MIF asserts its biological activity has yet to be fully understood, it has become clear in recent years that for certain phenotypes of cancer, MIF represents a valid therapeutic target. Current research efforts have focused on small molecule approaches that target MIF's unique tautomerase active site and neutralization of MIF with anti‐MIF antibodies. These approaches have yielded promising results in a number of preclinical murine cancer models and have helped to increase our understanding of MIF biological activity. More recently, MIF's involvement in a number of key protein–protein interactions, such as with CD74 and HSP90, has been highlighted and provides a novel platform for the development of anti‐MIF chemotherapeutic strategies in the future.