tbuckley/cabot-search huggingface dataset:
SAT0194 Evaluation of Systemic Sclerosis Patients by Quantitative Sensory Testing for the Presence of Neuropathy
Authors: L. Kilic, A. Akdogan, O. Karadag, U. Kalyoncu, S. Apras Bilgen, I. Ertenli, S. Kiraz
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Neuropathy is a common feature of collagen tissue disorders. Although development of digital ulcerations may be associated with presence of neuropathy, percentage of systemic sclerosis (SSc) patients with documented neuropathy is low. Quantitative sensory testing (QST) has been used to detect and characterize neuropathies. <h3>Objectives</h3> The aim of this study is to evaluate the patients with SSc by using QST for the presence of small and large fiber neuropathies and to investigate the association between digital ulcers and neuropathy. <h3>Methods</h3> We studied 50 SSc patients (46 (92%) were female). Demographic and clinical features of all patients were recorded. Michigan Neuropathy Screening Instrument (MNSI) questionnaire was performed in all subjects. MNSI questionnaire score ≥4 was considered to be abnormal. QST was performed using a CASE IV machine (WR Medical Electronics, Stillwater, Minnesota). Vibration and cold detection thresholds were measured using a 4, 2, and 1 stepping algorithm with null stimuli in the left foot and left hand. An increased threshold was defined as &gt;99 percentile. <h3>Results</h3> The mean age and the median disease duration of SSc patients was 47±12 years, 111 (12- 480) months, respectively. Thirty (60%) patients had limited SSc The median modified Rodnan9s score of the patients was 7 (3-29). Thirty (60%) patients had digital ulcer history. Ten (20%) patients had ≥4 MNSI questionnaire scores. The abnormal hand and foot vibration-detection thresholds were found in 26 (52%) and 20 (40%) patients. The abnormal hand and food cold-detection thresholds were found in 3 (6%) and 7 (14%) patients. The mean disease duration or the mean hand MRS were not different between patients with or without abnormal QST values for cold or vibration detected thresholds (p NS for all). Number of patients with DU history or SSc type were not different between patients with abnormal QST values for cold or vibration detected thresholds or not (p NS for all). <h3>Conclusions</h3> This study revealed that although there were significant percent of SSc patiens who had abnormal cold and vibration threshold values by QST, there were no association of clinical features of SSc with abnormal QST values. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3929
FRI0398 Derailed b cell homeostasis in patients with mixed connective tissue disease
Authors: A. Hajas, S. Barath, P. Szodoray, B. Nakken, P. Gogolak, Z. Szekanecz, E. Bodolay
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Mixed connective tissue disease (MCTD) is a systemic autoimmune disorder, characterized by the presence of antibodies to U1-RNP protein. Although the exact pathogenesis of MCTD is still unknown, B cell abnormalities characterized by autoantibody formation and polyclonal B cell activation play an important role. <h3>Objectives</h3> The aim of the present study was to assess the peripheral B cell subsets in MCTD in the active and inactive stage of the disease, compared with healthy individuals. In order to evaluate the clinical relevance of these findings, the frequencies of B cell subsets were correlated with disease activity and autoantibody levels. <h3>Methods</h3> Freshly drawn peripheral blood samples were obtained from 46 MCTD patients, and 20 age- and sex-matched healthy controls. Using anti-CD19, anti-CD27, anti-IgD and anti-CD38 monoclonal antibodies, the following B cell subsets were identified by flow cytometry: 1.transitional B cells (CD19+CD27-IgD+CD38high); 2.naive B cells (CD19+CD27-IgD+CD38low); 3.non-switched memory B cells (CD19+CD27+IgD+); 4.switched memory B cells (CD19+CD27+IgD-); 5.double negative (DN) memory B cells (CD19+CD27-IgD-) and 6.plasma cells (CD19+CD27highIgD-). Disease activity of MCTD was assessed by SLAM score. <h3>Results</h3> The proportion of transitional B cells, naive B cells and DN B lymphocytes was higher in MCTD than in controls. Active, untreated MCTD patients had both elevated percentages and absolute numbers of CD19+CD27-IgD+CD38high transitional B cells, compared to the inactive stage (%: p&lt;0.009; absolute number: p&lt; 0.045). Both the relative and absolute number of naive B cells (CD19+CD27-IgD+CD38low) was higher in the active disease, than in the inactive stage (%: p&lt; 0.002; absolute number: p&lt;0.001). The distribution of CD27high plasma cells was significantly higher in patients with MCTD compared to healthy controls (p&lt;0.001), while in the active stage, the proportion of CD27high plasma cells further increased (p&lt;0.001). Positive correlation was found between the number of plasma cells and anti-U1RNP levels. The DN B cells were positive for CD95 surface marker. This memory B cells population showed a close correlation with disease activity (p&lt;0.001). <h3>Conclusions</h3> Several abnormalities were found in the peripheral B cell subsets in MCTD, which reinforces the role of derailed humoral autoimmune processes in the pathogenesis of MCTD. <b>Disclosure of Interest</b>: None Declared
ANOMALOUS CORONARY ARTERIES AND ITS ASSOCIATION WITH INCIDENCE OF CORONARY ARTERY ATHEROSCLEROSIS: A STUDY FOM A TERTIARY-CARE TEACHING HOSPITAL
Authors: Jimmy Yee, Shilpkumar Arora, Sopan Lahewala, Vishesh Kumar, Amol Raizada, Amornpol Anuwatworn, Umesh Gidwani, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2016)
P104 T Helper 1 and T Helper 22 cell responses against Pseudomonas aeruginosa infections
Authors: H. K. Bayes, T. Evans
Journal: Thorax (2010)

<h3>Introduction</h3> <i>Pseudomonas aeruginosa</i> is an important opportunistic respiratory pathogen responsible for ventilator-associated pneumonia, acute lower respiratory tract infections in immunocompromised patients and chronic respiratory infections in cystic fibrosis. Antibody-mediated adaptive immune responses exist in cystic fibrosis patients but these lack protective opsonic activity. The role of CD4<sup>+</sup>T cell responses to Pseudomonas remains unclear. Novel T helper (Th) cell subsets have also recently been defined; Th22 cells produce IL-22, whereas Th17 cells produce IL-17 cytokines in addition to IL-21 and IL-22. The properties of IL-22-producing CD4<sup>+</sup> cells in humans remains to be defined, but include an important respiratory anti-microbial defense function. Immunopathological roles of Th17/Th22 cells may also exist. We assessed T-helper cell responses to Pseudomonas in healthy adults. <h3>Methods</h3> CD14<sup>+</sup> monocytes and memory CD4<sup>+</sup>CD45RO<sup>+</sup>T cells were isolated from peripheral blood using magnetic-activated cell sorting. Monocyte-derived dendritic cells (DCs) were generated by culture in the presence of IL-4 and GM-CSF. DCs were stimulated with live Pseudomonas aeruginosa strain PA103. DC activation markers, CD40 and CD86, were measured via flow cytometry. Autologous T cells were co-cultured with activated DCs, or their supernatants, for 6-days. T cell phenotype was analysed via flow cytometry and ELISA of supernatants for secreted cytokines. T cell incorporation of carboxyfluorescein-succinimidyl-ester was utilised to demonstrate cell multiplication. <h3>Results</h3> We demonstrate that monocyte-derived DCs from healthy adults are readily activated by Pseudomonas. Co-culture of autologous memory CD4<sup>+</sup>T cells with Pseudomonas-activated DCs resulted in CD4<sup>+</sup> T cells primarily producing IFN-gamma, as well as T cell subsets expressing both IFN-gamma and IL-22, or IL-22 alone. No Th17 response to Pseudomonas was evident. The response was MHC-restricted and specific T cell proliferation was demonstrated. Reproducibility of the response within individuals was also shown. <h3>Conclusions</h3> These data demonstrate that healthy adults possess Th1 and Th22 memory cell responses to <i>Pseudomonas aeruginosa</i>. The results may have important implications for patients with deficits in cellular immunity and the pathogenesis of chronic pseudomonas infection in cystic fibrosis. Further work is required to ascertain cross-reactivity of response, antigenic triggers, and the role these cellular responses play in protection vs pathogenesis in Pseudomonal pulmonary infections.
Payment by Capitation and the Quality of Care
Authors: D M Berwick
Journal: New England Journal of Medicine (1996)

Capitation and decapitation have nothing to do with each other, but you could hardly tell the difference when observing the intense debate over the value and risks of capitation in health care payment. Those who favor capitation seem to regard it as the sine qua non of effective containment of health care costs; those who oppose it suggest that it will spell nothing less than the end of medicine's commitment to patient advocacy and the Hippocratic oath. Meanwhile, health care coverage for more and more Americans is paid for in this way. Between 1987 and 1995, for example, the number . . .
S84 The effect of patient ventilator asynchrony (PVA) on health related quality of life during initiation of home mechanical ventilation (HMV)
Authors: MC Ramsay, S Mandal, E- Suh, J Steier, A Simonds, N Hart
Journal: Thorax (2013)

<h3>Introduction</h3> Poor patient-ventilator interaction has been shown to adversely affect respiratory muscle unloading, sleep quality, gas exchange and patient comfort whilst on ventilation. We hypothesised that nocturnal PVA during the first 3 months HMV initiation would have an adverse effect on patient health related quality of life. <h3>Methods</h3> Recording neural respiratory drive, as assessed by the parasternal intercostal electromyogram, respiratory inductance plethysmography and mask pressure waveform we performed a comprehensive assessment of PVA overnight both on initiation of HMV and at 3 months. Asynchrony levels were recorded as a percentage of the total of number of breaths that were both requested and received by the patient overnight. The severe respiratory insufficiency questionnaire (SRI) was completed by patients at both of these hospital visits. Daytime arterial partial pressure of carbon dioxide (P<sub>a</sub>CO<sub>2</sub>) was also assessed. <h3>Results</h3> 16 patients (8 male) admitted for initiation of HMV were recruited. 7 with neuromuscular or chest wall disease, 6 with chronic obstructive pulmonary disease and 3 with obesity related respiratory failure. Adherence to ventilation at 3 months was 6h 38m (1h35m-7h32m). There was an overall improvement in SRI scores of 9.5 (-0.7 to 18.2) points with the largest improvement observed in the anxiety component with an increase of 20 (5.6–35) points followed by the sleep component of 12.5 (3.6–28.6) points over the 3 months. A significant inverse correlation was observed with the change in asynchrony levels and the change in SRI scores over the 3 month assessment period (r<sub>s</sub> = -0.70; p = 0.02; Figure 1). No significant correlation was observed between the change in P<sub>a</sub>CO<sub>2</sub> and change in SRI score. <h3>Conclusion</h3> Enhancing patient-ventilator interaction, in particular reducing patient-ventilator asynchrony, had a direct correlation with improving health related quality of life of patients receiving HMV. Importantly, the anxiety and sleep components of the SRI were the most improved over the 3 months of treatment indicating the enhancement in perceived sleep quality with the psychological benefit of HMV treatment.
Detection of Left-Ventricular-Wall Motion Disorders in Coronary-Artery Disease by Radarkymography
Authors: Thomas M. Kazamias, Martin P. Gander, John Ross, Eugene Braunwald, Joseph D. Byrne
Journal: New England Journal of Medicine (1971)

Radarkymography, a new, noninvasive technic that records horizontal movements of the cardiac silhouette as projected on a television screen, was used to detect and sequentially to follow left-ventricular-wall motion disorders in patients with acute myocardial infarction and chronic coronary-artery disease. Asynergistic motion of the left ventricular wall was recorded in 44 of the 56 patients studied. Over a follow-up period extending up to 18 months, 36 of the 54 patients surviving the acute episode retained the asynergism of contraction. Ten of the 44 patients with wall motion abnormalities expired. Wall motion abnormalities were also recorded in 28 of 42 patients with chronic coronary-artery disease. Radarkymography was compared with left ventricular cineangiography in 18 patients, and in 16 of these the results were identical in detection of asynergy of contraction. Radarkymography was found to be more accurate than fluoroscopy since wall motion disorders could not be detected in 16 of 32 patients with chronic coronary-artery disease in whom such abnormalities could be demonstrated by radarkymography.
Effect of Vertical Displacement of the Arm on Indirect Blood-Pressure Measurement
Authors: Paul L. Mitchell, R. Willis Parlin, Henry Blackburn
Journal: New England Journal of Medicine (1964)

GREAT importance is given to indirect auscultatory blood-pressure measurement for its convenience and value both as an indicator of an underlying disorder and as a predictor of future cardiovascular-renal disease — despite its known lack of precision. Use of the technic in descriptive and experimental studies in large population groups such as those directed from this laboratory imposes greater demands on this clinical tool than those required for adequate evaluation of individual patients in the clinic. Of many sources of variation and error small systematic differences in particular may lead to significant, spurious differences in comparative studies.Bordley et al. . . .
AB0873 A Randomized Double-Blind Placebo-Controlled Study Adding High Dose Vitamin D to Analgesic Regimens in Patients with Musculoskeletal Pain: Table 1.
Authors: O. Gendelman, D. Itzhaki, H. Amital
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The current mode of therapy for many patients with musculoskeletal is unsatisfactory. <h3>Objectives</h3> To assess the impact of adding 4,000 IU of vitamin D on pain and serological parameters in patients with musculoskeletal. <h3>Methods</h3> The study was a randomized, double-blinded and placebo-controlled assessing the effect of 4,000 IU of orally given vitamin D3 (cholecalciferol) (four gel capsules of 1,000IU (SupHerb, Israel) vs. placebo on different parameters of pain. Eighty patients were enrolled and therapy was given for 3 months. Parameters were scored at three time points: prior to intervention, at week 6 and 12. The primary outcome was the percentage of patients achieving a 50% reduction on the VAS score following 3 months. We also measured serum levels of leukotriene B4 (LTB4), Interleukin 6 (IL-6), tumor necrosis factor alpha (TNFα) and Prostaglandin E2 (PGE2) by ELISA. <h3>Results</h3> The group receiving vitamin D achieved a statistically significant larger decline of their VAS measurement throughout the study compared with the placebo group (Table 1). The need for analgesic "rescue therapy" was significantly lower among the vitamin D treated group. TNFα levels decreased by 54.3% in the group treated with vitamin D and increased by 16.1% in the placebo group. PGE2 decrease of 39.2% in the group treated with vitamin D and increased by 16.1LTB4 levels decreased in both groups by 24% (p&lt;0.05). <h3>Conclusions</h3> Adding 4,000 IU of vitamin D to patients with musculoskeletal pain may lead to a faster decline of consecutive VAS scores and to a decrease in the levels of inflammatory and pain related cytokines. <h3>Disclosure of Interest</h3> O. Gendelman: None declared, D. Itzhaki: None declared, H. Amital Grant/research support: Pfizer, Abvie, Consultant for: MSD <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2555
A POOLED SAFETY ANALYSIS OF OVER 6000 PATIENTS FROM DOUBLE-BLIND AND OPEN-LABEL EXTENSION STUDIES WITH EVOLOCUMAB
Authors: Peter P. Toth, Olivier Descamps, Jacques Genest, Naveed Sattar, David Preiss, Ricardo Dent, Constantine Djedjos, Yuna Wu, Michelle Geller, Ransi Somaratne, Scott Wasserman, Evan Stein
Journal: Journal of the American College of Cardiology (2016)
Tamoxifen: Tablet Dosage
Authors: GEORGE E. MOORE
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Tamoxifen: Tablet Dosage Get access GEORGE E. MOORE GEORGE E. MOORE Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 1, 1 January 1992, Pages 61–62, https://doi.org/10.1093/jnci/84.1.61 Published: 01 January 1992
Abstract P3-10-06: Patterns of failure in patients with inflammatory breast cancer: the case for aggressive local/regional treatment
Authors: LE Warren, MM Regan, F Nakhlis, ED Yeh, HA Jacene, J Hirshfield-Bartek, BA Overmoyer, JR Bellon
Journal: Cancer Research (2012)

Abstract Background: While the survival of patients with inflammatory breast cancer (IBC) is dictated by the status of their distant metastases, local/regional control remains an important component of quality of life. We have sought to determine patterns of local/regional recurrence (LRR) in patients presenting with inflammatory breast cancer. Methods: The medical records of 92 patients (pts) diagnosed with IBC from 1997 until 2007 were reviewed. Pt cohorts were stratified by disease burden at presentation (metastatic or local/regional) and their tumor, treatment, and disease course were analyzed. Primary outcomes were time from diagnosis to LRR, time to distant recurrence, and overall survival (OS). Median follow-up (MFU) for the entire cohort was 6 years (yrs) (range 0.1 to 12.7 yrs); for those patients who presented with metastatic disease versus only local/regional disease, MFU is 2 yrs and 6 yrs, respectively. This study was approved by the hospital institutional review board. Results: Median age at diagnosis was 49 yrs (range 24 to 72). 68 (74%) patients were without evidence of metastatic disease on presentation. With 6yr MFU, 40/68 (59%) had disease recurrence at either local or distant sites, and 15/68 (22%) had documented LRR, either as the first or subsequent site of recurrence. Estimated 5yr OS is 64%. 24 (26%) pts presented with metastatic disease (lung, liver, distant lymph nodes, pleura). All of the 24 pts presenting with metastatic disease developed systemic disease progression; 12/24 (50%) also developed LRR, and for 9/12 pts the LRR was first progression or concurrent with distant progression. Eleven of the 24 pts did not receive radiation or surgery; and within this cohort, 7 (64%) pts developed LLR at a median time of 9 months after diagnosis. Six pts received radiation therapy without surgery; 3/6 (50%) developed LRR. One pt had surgery alone; this patient was not known to have LRR, although had limited follow-up. Six pts received radiation therapy and surgery; 1 for palliation and 5 to prevent LRR. Of these 5 pts, 1/5 (20%) developed LRR that extended to the contralateral breast at 1.2y after diagnosis. Among the 24 patients, the cumulative incidence of LRR was 29%, 37%, and 43% at 1yr, 2yr, and 3yr (accounting for competing risk of death). The median OS was 2.9 yrs and estimated 5yr OS was 36%. Conclusions: Pts with inflammatory breast carcinoma presenting with metastatic disease are at high risk for local/regional disease progression. Aggressive local therapy should be considered to prevent symptoms of uncontrolled local disease, despite an uncertain impact upon OS. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-10-06.
Fusion FDG-PET/MRI Evidence to Support Diagnosis of Frontotemporal Dementia–Related Primary Progressive Aphasia
Authors: Aaron VanDreel, Syed A. Aftab, Prateek Sanan, Christopher Grant, Yang Lu
Journal: Clinical Nuclear Medicine (2016)

A 61-year-old right-handed man presented for cognitive neurological evaluation with word-finding difficulty, impaired word retrieval, impaired repetition of phrases, and stammering. Brain MRI and FDG-PET/CT were performed as initial imaging workup. Further FDG PET/MRI brain images were obtained through software fusion and revealed regional cortical atrophy with corresponding hypometabolic activity involving the posterior aspects of the left middle and inferior temporal gyri. These characteristic imaging findings are supportive of patient's diagnosis of frontotemporal dementia-related primary progressive aphasia.
Usefulness of RNA polymerase II coding sequences for estimation of green plant phylogeny
Authors: A. L. Denton, B. L. McConaughy, B. D. Hall
Journal: Molecular Biology and Evolution (1998)

Phylogenetic reconstruction based on chloroplast (cp) and nuclear ribosomal (r)DNA sequences have contributed greatly to our understanding of green plant evolution.Many relationships remain unresolved, however, especially among basal angiosperm taxa.Here, both plastid and ribosomal gene analysis have generated inconclusive, and occasionally contradictory, hypotheses of deep branching topology (Chase et al. 1993;Soltis et al. 1997).Such incongruities underscore the need for sequence data from additional independent loci.The pilot study we report here was motivated by an interest in studying the early diversification of land plants.Toward this end, we PCR-amplified and sequenced the genes encoding the second largest subunit of RNA polymerase II (RPB2) from nine taxa representing tricolpate, monosulcate, and eudicot angiosperm lineages, one gymnosperm, and one liverwort species to determine the feasibility of recovering the RPB2 gene from any green plant using a single set of PCR primers.We also performed a preliminary evaluation of the potential phylogenetic utility of RPB2 sequences.Other than the widely studied large-and small-subunit rDNA genes, protein-encoding genes are the main potential source of comparative nuclear DNA sequence.In plants, many of these genes are members of repeated families, complicating phylogenetic comparisons with issues of paralogy and within-family concerted evolution.These problems were noted in phylogenetic studies with the genes for phytochrome (Mathews, Lavin, and Sharrock 1995), small heat shock proteins (Waters 1995), and cytosolic phosphoglucose isomerase (Gottlieb and Ford 1996).Currently, the nuclear gene with the broadest phylogenetic applicability in plants is alcohol dehydrogenase (Adh), but separate gene duplication events within angiosperm lineages may limit the utility of universal angiosperm Adh primers (Morton, Gaut, and Clegg 1996;Sang, Donoghue, and Zhang 1997).The identification of nonrepeated nuclear genes that evolve at rates suitable for interfamilial phylogenetic assessment is made difficult by the paucity of comparative sequence data currently available for plant nuclear genomes.In principle, promising nuclear genes for such studies are those that encode components of the multiprotein assemblies involved in the apparatuses for replication and transcription in the cell nucleus.These pro-