tbuckley/cabot-search huggingface dataset:
Granulysin in pulmonary veno-occlusive disease
Authors: Frédéric Perros, Sylvia Cohen-Kaminsky, Natalia Gambaryan, Barbara Girerd, Nicolas Raymond, Isabelle Klingelschmitt, Alice Huertas, Olaf Mercier, Elie Fadel, Gerald Simonneau, Marc Humbert, Peter Dorfmüller, David Montani
Journal: European Respiratory Journal (2013)

Background:  Pulmonary Veno-Occlusive Disease (PVOD) shares many similarities with precapillary Pulmonary Arterial Hypertension (PAH), from risk factors to clinical or hemodynamic presentation. The need to establish a correct diagnosis of PVOD is justified by the worse prognosis of these patients and by their risk of developing severe pulmonary edema with specific PAH therapy.   Aims and objectives:  To show that the cytolytic subpopulation of inflammatory cells is differently regulated in PAH and PVOD patients and to identify a biological tool to distinguish these two entities.   Methods:  The functional status of the cytolytic compartment was studied through epigenetic analysis of the Granulysin (GNLY), a powerful effector for these subpopulations in explanted lungs and in PBMC. Flow cytometry allowed analysis of circulating cytolytic cells and GNLY contents. A GNLY-specific ELISA allowed measurement of GNLY serum concentrations.   Results:  A decrease in GNLY demethylation in the DNA extracted from PBMC and lungs was found in PVOD but not in PAH. This was associated with a decrease in populations and subpopulations of cytotoxic T-(CTL), and Natural Killer T-(NKT) cells, and an increase of Natural Killer-(NK) populations. Despite the reduced GNLY-containing cells in PVOD, GNLY serum levels were higher, suggesting these cells were wasting their content. Furthermore, the increase of GNLY concentration in the serum of PVOD was higher than in PAH patients.   Conclusions:  PVOD is characterized by alterations of circulating cytotoxic cell-subpopulations and by epigenetic dysregulation within the GNLY gene. Our findings may be helpful to develop needed biological tools in order to screen for suspected PVOD in patients with pulmonary hypertension.
CONTACT PHOTOALLERGY TO TRIBROMSALICYLANILIDE
Authors: P. E. OSMUNDSEN
Journal: British Journal of Dermatology (1969)

SUMMARY. . It has been demonstrated that 5,4′ -dibromsalicylanilide (5,4′DBS) and 4′-monobromsalicy Ianilide (4′MBS) are produced by irradiating 3,5,4′-tribromsalicylanilide (TBS) and 5,4′DBS respectively in vitro. By further irradiation a coloured product is produced. In patients photosensitized by TBS, experimental photopatch tests have been carried out with these substances and some related agents. The photopatch reactions to 4′MBS were on a level with the reactions to TBS and 5,4′DBS, while only few and weak reactions were elicited with 3,5 DBS and salicylanilide. In 8 of 14 patients 4′MBS elicited positive simple patch tests, the reactions being intensified by u.v. The coloured product evoked strong photopatch test reactions, the simple patch tests being negative in all patients but one. As 4′MBS has been reported not to be affected by u.v. it is suggested that in photosensitization to TBS the 4′-position and the halogen substituted here is a key point in the sensitization process.
ITCHING ERUPTION IN MINERS CAUSED BY A RARE BEETLE (TRIBOLEUM CASTANEUM).
Authors: D. M. WILLIAMSON
Journal: British Journal of Dermatology (1964)

Journal Article ITCHING ERUPTION IN MINERS CAUSED BY A RARE BEETLE (TRIBOLEUM CASTANEUM). Get access D. M. WILLIAMSON, M.D., D.I.H. D. M. WILLIAMSON, M.D., D.I.H. Medical Services, National Coal Board, Yorkshire Division, Doncaster Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 8-9, 1 August 1964, Pages 388–389, https://doi.org/10.1111/j.1365-2133.1964.tb14549.x Published: 01 August 1964
Calcium Deposition with or without Bone Formation in the Lung
Authors: Edward D. Chan, Donald V. Morales, Carolyn H. Welsh, Michael T. McDermott, Marvin I. Schwarz
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Section:ChooseTop of pageAbstract <<CONTENTSCLINICAL CLASSIFICATION O...PROPOSED MECHANISMS OF EC...IMAGINGSPECIFIC DISORDERSReferencesCITING ARTICLES
Comparison of nasal pressure support ventilation with nasal intermittent positive pressure ventilation in patients with nocturnal hypoventilation
Authors: LJ Restrick, NC Fox, G Braid, EM Ward, EA Paul, JA Wedzicha
Journal: European Respiratory Journal (1993)

Nasal intermittent positive pressure ventilation (NIPPV) provides effective ventilatory support in patients with nocturnal hypoventilation. Nasal pressure support ventilation (NPSV), which only provides ventilation in response to patient triggering, may also be effective, simpler, and cheaper, but has not been evaluated. NIPPV and NPSV were compared in 12 patients with nocturnal hypoventilation, requiring domiciliary ventilatory support. The patients were studied on three consecutive nights, in random order: a control night without ventilation and a night on each mode of ventilatory support using the bilevel positive airway pressure (BiPAP) ventilator. Both NIPPV and NPSV significantly increased mean arterial oxygen saturation (SaO2) compared to the control night (NIPPV mean increase 4.1%; 95% confidence interval (CI) 2.2 to 6.1, NPSV 4.4%; CI 2.1 to 6.6) with no significant difference between the two modes. The percentage of the study night spent below 90% SaO2 was significantly reduced by both ventilator modes compared to the control night (median reduction on NIPPV 37%; CI -54 to -10, reduction on NPSV 31%; CI -53 to -9, with no significant difference between NPSV and NIPPV. NPSV was as effective as NIPPV in patients with nocturnal hypoventilation, which suggests that these patients are able to trigger the ventilator adequately. The lower cost of NPSV will make it accessible to more patients with chronic lung disease.
Perifosine Plus Bortezomib and Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma Previously Treated With Bortezomib: Results of a Multicenter Phase I/II Trial
Authors: Paul G. Richardson, Jeff Wolf, Andrzej Jakubowiak, Jeff Zonder, Sagar Lonial, David Irwin, John Densmore, Amrita Krishnan, Noopur Raje, Michael Bar, Tom Martin, Robert Schlossman, Irene M. Ghobrial, Nikhil Munshi, Jacob Laubach, Jeff Allerton, Teru Hideshima, Kathleen Colson, Enrique Poradosu, Lesa Gardner, Peter Sportelli, Kenneth C. Anderson
Journal: Journal of Clinical Oncology (2011)

Purpose Novel agents have improved patient outcome in relapsed or relapsed/refractory multiple myeloma (MM). Preclinical data show that the novel signal transduction modulator, perifosine, enhances the cytotoxicity of dexamethasone and bortezomib. Clinical data suggest that perifosine in combination with dexamethasone has activity in relapsed or relapsed/refractory MM. Patients and Methods In a phase I/II study, perifosine in combination with bortezomib with or without dexamethasone was prospectively evaluated in 84 patients with relapsed or relapsed/refractory MM. All were heavily pretreated and bortezomib exposed; 73% were refractory to bortezomib, and 51% were refractory to bortezomib and dexamethasone. The dose selected for the phase II study was perifosine 50 mg/d plus bortezomib 1.3 mg/m 2 , with the addition of low-dose dexamethasone at 20 mg if progression occurred on perifosine plus bortezomib alone. Results An overall response rate (ORR; defined as minimal response or better) of 41% was demonstrated with this combination in 73 evaluable patients, including an ORR of 65% in bortezomib-relapsed patients and 32% in bortezomib-refractory patients. Therapy was generally well tolerated; toxicities, including gastrointestinal adverse effects and fatigue, proved manageable. No treatment-related mortality was seen. Median progression-free survival was 6.4 months, with a median overall survival of 25 months (22.5 months in bortezomib-refractory patients). Conclusion Perifosine–bortezomib ± dexamethasone demonstrated encouraging activity in heavily pretreated bortezomib-exposed patients with advanced MM. A phase III trial is underway comparing perifosine–bortezomib plus dexamethasone with bortezomib–dexamethasone in patients with relapsed/refractory MM previously treated with bortezomib.
Importance of NF-kappaB in rheumatoid synovial tissues: in situ NF-kappaB expression and in vitro study using cultured synovial cells
Authors: S Yamasaki
Journal: Annals of the Rheumatic Diseases (2001)

To examine whether inhibition of NF-kappaB induces apoptosis of human synovial cells stimulated by tumour necrosis factor alpha (TNFalpha), interleukin 1beta (IL1beta), and anti-Fas monoclonal antibody (mAb).The expression of proliferating cell nuclear antigen (PCNA), NF-kappaB, and the presence of apoptotic synovial cells were determined in synovial tissues. Apoptosis of cultured synovial cells was induced by inhibition of NF-kappaB nuclear translocation by Z-Leu-Leu-Leu-aldehyde (LLL-CHO). The activation of caspase-3 and expression of XIAP and cIAP2 in synovial cells in LLL-CHO induced apoptosis was also examined.Abundant PCNA+ synovial cells were found in rheumatoid arthritis (RA) synovial tissue, though a few apoptotic synovial cells were also detected in the RA synovial tissues. Nuclear NF-kappaB was expressed in RA synovial cells. Electrophoretic mobility shift assay showed that treatment of cells with TNFalpha or IL1beta significantly stimulated nuclear NF-kappaB activity. A small number of apoptotic synovial cells expressing intracellular active caspase-3 were found after treatment of cells with LLL-CHO. Although treatment of RA synovial cells with TNFalpha or IL1beta alone did not induce apoptosis, apoptosis induced by LLL-CHO and caspase-3 activation were clearly enhanced in TNFalpha or IL1beta stimulated synovial cells compared with unstimulated synovial cells. Furthermore, induction of apoptosis of synovial cells with caspase-3 activation by anti-Fas mAb was clearly increased by LLL-CHO. The expression of cIAP2 and XIAP in synovial cells may not directly influence the sensitivity of synovial cells to apoptosis induced by LLL-CHO.The results suggest that NF-kappaB inhibition may be a potentially important therapeutic approach for RA by correcting the imbalance between apoptosis and proliferation of synovial cells in RA synovial tissue.
Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring
Authors: Taotao Lao, Kimberly Glass, Weiliang Qiu, Francesca Polverino, Kushagra Gupta, Jarrett Morrow, John Dominic Mancini, Linh Vuong, Mark A Perrella, Craig P Hersh, Caroline A Owen, John Quackenbush, Guo-Cheng Yuan, Edwin K Silverman, Xiaobo Zhou
Journal: Genome Medicine (2015)
Cardiovascular Effects of 1 Year of Progressive and Vigorous Exercise Training in Previously Sedentary Individuals Older Than 65 Years of Age
Authors: Naoki Fujimoto, Anand Prasad, Jeffrey L. Hastings, Armin Arbab-Zadeh, Paul S. Bhella, Shigeki Shibata, Dean Palmer, Benjamin D. Levine
Journal: Circulation (2010)

Background— Healthy but sedentary aging leads to cardiovascular stiffening, whereas life-long endurance training preserves left ventricular (LV) compliance. However, it is unknown whether exercise training started later in life can reverse the effects of sedentary behavior on the heart. Methods and Results— Twelve sedentary seniors and 12 Masters athletes were thoroughly screened for comorbidities. Subjects underwent invasive hemodynamic measurements with pulmonary artery catheterization to define Starling and LV pressure-volume curves; secondary functional outcomes included Doppler echocardiography, magnetic resonance imaging assessment of cardiac morphology, arterial stiffness (total aortic compliance and arterial elastance), and maximal exercise testing. Nine of 12 sedentary seniors (70.6±3 years; 6 male, 3 female) completed 1 year of endurance training followed by repeat measurements. Pulmonary capillary wedge pressures and LV end-diastolic volumes were measured at baseline, during decreased cardiac filling with lower-body negative pressure, and increased filling with saline infusion. LV compliance was assessed by the slope of the pressure-volume curve. Before training, V̇ o 2 max, LV mass, LV end-diastolic volume, and stroke volume were significantly smaller and the LV was less compliant in sedentary seniors than Masters athletes. One year of exercise training had little effect on cardiac compliance. However, it reduced arterial elastance and improved V̇ o 2 max by 19% (22.8±3.4 versus 27.2±4.3 mL/kg/mL; P &lt;0.001). LV mass increased (10%, 64.5±7.9 versus 71.2±12.3 g/m 2 ; P =0.037) with no change in the mass-volume ratio. Conclusions— Although 1 year of vigorous exercise training did not appear to favorably reverse cardiac stiffening in sedentary seniors, it nonetheless induced physiological LV remodeling and imparted favorable effects on arterial function and aerobic exercise capacity.
Alkaline phosphatase immuno-enzymatic technique in the diagnosis of pemphigus vulgaris
Authors: E. TUR, N. VARDINON, E. EYLAN, B. FRISCH, S. BRENNER, M. WEINBERG, A. KRAKOWSKI
Journal: British Journal of Dermatology (1983)

Journal Article Alkaline phosphatase immuno‐enzymatic technique in the diagnosis of pemphigus vulgaris Get access E. TUR, E. TUR Departments of Dermatology, Ichilov Medical Center, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar N. VARDINON, N. VARDINON Microbiology, Ichilov Medical Center, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar E. EYLAN, E. EYLAN Microbiology, Ichilov Medical Center, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar B. FRISCH, B. FRISCH Haematology, Ichilov Medical Center, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar S. BRENNER, S. BRENNER Departments of Dermatology, Ichilov Medical Center, Tel Aviv, Israel S.Brenner, M.D., Department of Dermatology, Ichilov Medical Center, Weizmann St., Tel Aviv 64239, Israel. Search for other works by this author on: Oxford Academic Google Scholar M. WEINBERG, M. WEINBERG Microbiology, Ichilov Medical Center, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar A. KRAKOWSKI A. KRAKOWSKI Departments of Dermatology, Ichilov Medical Center, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 1, 1 January 1983, Pages 77–82, https://doi.org/10.1111/j.1365-2133.1983.tb04581.x Published: 01 January 1983 Article history Accepted: 18 May 1982 Published: 01 January 1983
Progress Toward a Human CD4/CCR5 Transgenic Rat Model for De Novo Infection by Human Immunodeficiency Virus Type 1
Authors: Oliver T. Keppler, Frank J. Welte, Tuan A. Ngo, Peggy S. Chin, Kathryn S. Patton, Chia-Lin Tsou, Nancy W. Abbey, Mark E. Sharkey, Robert M. Grant, Yun You, John D. Scarborough, Wilfried Ellmeier, Dan R. Littman, Mario Stevenson, Israel F. Charo, Brian G. Herndier, Roberto F. Speck, Mark A. Goldsmith
Journal: The Journal of Experimental Medicine (2002)

The development of a permissive small animal model for the study of human immunodeficiency virus type (HIV)-1 pathogenesis and the testing of antiviral strategies has been hampered by the inability of HIV-1 to infect primary rodent cells productively. In this study, we explored transgenic rats expressing the HIV-1 receptor complex as a susceptible host. Rats transgenic for human CD4 (hCD4) and the human chemokine receptor CCR5 (hCCR5) were generated that express the transgenes in CD4+ T lymphocytes, macrophages, and microglia. In ex vivo cultures, CD4+ T lymphocytes, macrophages, and microglia from hCD4/hCCR5 transgenic rats were highly susceptible to infection by HIV-1 R5 viruses leading to expression of abundant levels of early HIV-1 gene products comparable to those found in human reference cultures. Primary rat macrophages and microglia, but not lymphocytes, from double-transgenic rats could be productively infected by various recombinant and primary R5 strains of HIV-1. Moreover, after systemic challenge with HIV-1, lymphatic organs from hCD4/hCCR5 transgenic rats contained episomal 2–long terminal repeat (LTR) circles, integrated provirus, and early viral gene products, demonstrating susceptibility to HIV-1 in vivo. Transgenic rats also displayed a low-level plasma viremia early in infection. Thus, transgenic rats expressing the appropriate human receptor complex are promising candidates for a small animal model of HIV-1 infection.
Chronic ethanol consumption increases hepatic sinusoidal contractile response to endothelin-1 in the rat
Authors: Michael Bauer, Nicole C. Paquette, Jian X. Zhang, Inge Bauer, Benedikt H. J. Pannen, Steven R. Kleeberger, Mark G. Clemens
Journal: Hepatology (1995)

Recent evidence suggests that hepatic stellate cells function as liver-specific pericytes that are highly contractile in response to endothelin-1 (ET-1). Liver injury has been shown to lead to "activation" of stellate cells producing a phenotypic change to a more myofibroblastic cell type including loss of vitamin A and increased contractility. The present study was undertaken to test the effects of short-term chronic ethanol consumption (36% of total calories for 5 weeks according to the Lieber-DeCarli protocol) on hepatic vitamin A storage, expression of smooth muscle alpha-actin, and sinusoidal contractility in Sprague-Dawley rats. Using in vivo epifluorescence video microscopy, we quantified the number of sites of vitamin A fluorescence (purportedly stellate cells) and assessed sinusoidal microhemodynamics at baseline and during a 20-minute infusion period of ET-1 (1 pmol * 100 g body weight [bw]*1*min-1). Retinol and retinyl palmitate were measured after the experiment by means of high-pressure liquid chromatography (HPLC). A highly significant decrease in liver retinyl palmitate level (control: 622.5 +/- 50.9; ethanol: 273.0 +/- 38.0 microgram/g liver; P< .001) was found that correlated with a decrease in sites of vitamin A fluorescence (control: 531.4 +/- 76.1; ethanol: 141.1 +/- 30.2* mm-2; r = .82, P <.001). Concomitantly scattered expression of smooth muscle alpha-actin in sinusoids was observed. Although sinusoidal hemodynamics were not affected at baseline, a significant increase in sinusoidal contractility on endothelin-1 infusion (e.g., sinusoidal resistance [% of baseline value]: control: 10 minutes: 288.7 +/- 71.7, 20 minutes: 200.5 +/- 46.9; ethanol: 10 minutes: 1,916.0 +/- 701.7, 20 minutes: 656.8 +/- 103.3; P < .05 and .01, respectively) was observed. These data indicate that chronic ethanol consumption in this moderate model initiates stellate cell activation. Increased sinusoidal responsiveness to the vasoconstrictor ET-1 in vivo may contribute to the increased susceptibility of ethanol-fed rats to secondary stresses that increase ET-1 expression, such as endotoxemia.
Hereditary nonpolyposis colorectal cancer
Authors: S. O'Reilly, K.A. Johnson, J.D. Brensinger, F.M. Giardiello
Journal: Annals of Oncology (1997)

Colorectal cancer is a leading cause of cancer related death in both Europe and the United States. Approximately 20% of cases occur in familial aggregations making this disorder the most frequent form of hereditary neoplasia [1]. Consequently, patients with colorectal cancer often present with a positive family history which may have significant implications for their care. Recent advances in the genetic basis for some forms of hereditary colon cancer has led to the clinical availability of genetic testing for these patients. Hereditary non polyposis colorectal cancer (HNPCC) is an autosomal dominant condition characterized by an early age of colorectal cancer onset (median age 44 years), an excess of proximal colon tumors (70% proximal to the splenic flexure) and of metachronous disease, and an increased risk of extracolonic malignancies within the pedigree [2], Between 1% and 5% of all colorectal cancers may be attributable to this disorder [2, 3]. The syndrome was initially described in 1913 by Warthin, a
The value of high-dose methotrexate-based neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone.
Authors: S J Ham, H J Hoekstra, W T van der Graaf, W A Kamps, W M Molenaar, H Schraffordt Koops
Journal: Journal of Clinical Oncology (1996)

PURPOSE The value of high-dose methotrexate (HD-MTX)-based neoadjuvant chemotherapy was evaluated in patients with malignant fibrous histiocytoma (MFH) of bone. PATIENTS AND METHODS Since 1977, MFH of bone was diagnosed in 17 patients (12 males and five females). Ten patients (59%), completed treatment with four courses of neoadjuvant chemotherapy as follows: HD-MTX, vincristine, doxorubicin, cyclophosphamide, bleomycin, and dactinomycin, or HD-MTX, 4(1)-epidoxorubicin, and carboplatin followed by local tumor resection (n = 3), curettage-cryosurgery (n = 2), amputation (n = 2), or tumor resection-endoprosthetic replacement or allograft (n = 3). After recovery from surgery, an additional six courses of polychemotherapy, including HD-MTX in nine patients, were administered. One patient changed to cisplatin- instead of HD-MTX-containing chemotherapy postoperatively. One additional patient received only adjuvant HD-MTX-containing polychemotherapy. Neoadjuvant MTX-containing chemotherapy was contraindicated in five patients (29%) due to age, cardiac insufficiency, or mental disorder. In one patient, neoadjuvant chemotherapy was cancelled after one course due to renal failure. Treatment consisted of amputation (n = 2), one course of chemotherapy and amputation (n = 1), hyperthermic isolated limb perfusion (HILP; n = 1), intraarterial chemotherapy, radiotherapy, and endoprosthetic replacement (n = 1), and a combination of chemotherapy and radiation treatment (n = 1). RESULTS Five of six patients who received no HD-MTX-based neoadjuvant chemotherapy developed metastatic disease (83%); the median time to metastatic disease was 17 months (range, 3 to 44). In contrast, in 10 patients who completed treatment with HD-MTX-based neoadjuvant chemotherapy, with a mean follow-up time of 9.8 years (range, 2.3 to 15.7) and a median follow-up time of 10.8 years (range, 2.3 to 15.7) after diagnosis, no local recurrence or distant metastases were diagnosed (P &lt; .005). CONCLUSION Neoadjuvant HD-MTX-containing chemotherapy in addition to surgery has dramatically improved the prognosis of patients with MFH of bone.
Comparative Pathology of Cells Transformed by Herpes Simplex Virus Type 1 or Type 22
Authors: Ronald Duff, John W. Kreider, Barnet M. Levy, Myron Katz, Fred Rapp
Journal: JNCI Journal of the National Cancer Institute (1974)

The morphology of hamster embryo cells transformed after infection with ultraviolet-irradiated herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) was described. A cell line developed after transformation by HSV-1 showed an epithelioid morphology, and cells transformed by HSV-2 resembled fibroblastoid cells. Epithelioid cells induced adenocarcinomas and fibroblastoid cells induced fibrosarcomas on injection of 5×105 cells into newborn hamsters. Cells isolated from these tumors and grown in culture retained a morphology similar to that of the original cells before animal passage. They were readily transplantable to weanling hamsters. The pathology of the tumors in weanling hamsters again corresponded to the morphology of the cell injected.