tbuckley/cabot-search huggingface dataset:
Tourette's syndrome manifest as chronic cough in children
Authors: Teh-Ming Wang, Chin-Hua Su
Journal: European Respiratory Journal (2011)

Background:  Tourette9s syndrome (TS) is a neuropsychiatric disorder characterized by the presence of involuntary motor and phonics tics. Some of the involuntary phonic tics may present as coughing, grunting, and wheezing. These symptoms may easily be confused with the symptoms associated with the disorders causing chronic persistent cough. The purpose of this study was to present our experience of the clinical manifestation and treatment outcome of the TS.   Material and methods:  Retrospective review studies were done from Jan 2008 to Dec. 2010. There were 8 patients met the criteria of TS who initially present as chronic cough (cough > 4 weeks) in OPD.   Results:  Their ages ranged between 6 and 17 years old. Of these patients, 6 (75%) were boys, 2 (25%) were girls. The onset of vocal tics is less than 1 year after the onset of motor tics. All cases showed simultaneously multiple tics. The most common tics in TS were throat clearing (5/8), facial grimacing (4/8),mouth opening (4/8), barking cough (3/8), head turning (2/8), shoulder jerk (2/8). Two of 8 patients were associated with the behavioral disorders, obsessive-compulsive disorder (1/8), attention-deficit disorder (2/8). No known of positive familial history in our patients. All patients suffered from rhinitis more or less and S/S could fully remit after aggressive nasal management except 2 patients.   Conclusion:  We would like to point out that TS should also be considered in children with chronic cough. This may help prevent the potential unwanted effects of the drugs which are presumptively given to these patients.
EBMT Prospective Non-Interventional Study On Allogeneic Hematopoietic Stem Cell Transplantation In T-Prolymphocytic Leukemia (T-PLL). Preliminary Analysis Of 43 Patients
Authors: Wieslaw Wiktor Jedrzejczak, Simona Iacobelli, Jennifer D.C. Hoek, Joanna E Drozd-Sokolowska, Michael Potter, Gerald Wulf, Patrice Chevallier, Per T. Ljungman, Yener Koc, Johannes Schetelig, Theo de Witte, Nicolaus Kroeger, Peter Dreger
Journal: Blood (2013)
Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection
Authors: Lara Testai, Vincenzo Barrese, Maria Virginia Soldovieri, Paolo Ambrosino, Alma Martelli, Iolanda Vinciguerra, Francesco Miceli, Iain Andrew Greenwood, Michael John Curtis, Maria Cristina Breschi, Maria Josè Sisalli, Antonella Scorziello, Miren Josune Canduela, Pedro Grandes, Vincenzo Calderone, Maurizio Taglialatela
Journal: Cardiovascular Research (2015)

AimsPlasmalemmal Kv7.1 (KCNQ1) channels are critical players in cardiac excitability; however, little is known on the functional role of additional Kv7 family members (Kv7.2-5) in cardiac cells. In this work, the expression, function, cellular and subcellular localization, and potential cardioprotective role against anoxic-ischaemic cardiac injury of Kv7.4 channels have been investigated.
Surgical Intervention for Non–Small-Cell Lung Cancer Patients with Pleural Carcinomatosis: Results From the Japanese Lung Cancer Registry in 2004
Authors: Tomohiko Iida, Mitsutoshi Shiba, Ichiro Yoshino, Etsuo Miyaoka, Hisao Asamura, Hiroshi Date, Meinoshin Okumura, Hirohito Tada, Yoichi Nakanishi, Hirotoshi Dosaka-Akita, Hideo Kobayashi, Kazuhisa Takahashi, Masayoshi Inoue, Kohei Yokoi
Journal: Journal of Thoracic Oncology (2015)
Yarrowia lipolytica as a biotechnological chassis to produce usual and unusual fatty acids
Authors: Rodrigo Ledesma-Amaro, Jean-Marc Nicaud
Journal: Progress in Lipid Research (2015)

One of the most promising alternatives to petroleum for the production of fuels and chemicals is bio-oil based chemistry. Microbial oils are gaining importance because they can be engineered to accumulate lipids enriched in desired fatty acids. These specific lipids are closer to the commercialized product, therefore reducing pollutants and costly chemical steps. Yarrowia lipolytica is the most widely studied and engineered oleaginous yeast. Different molecular and bioinformatics tools permit systems metabolic engineering strategies in this yeast, which can produce usual and unusual fatty acids. Usual fatty acids, those usually found in triacylglycerol, accumulate through the action of several pathways, such as fatty acid/triacylglycerol synthesis, transport and degradation. Unusual fatty acids are enzymatic modifications of usual fatty acids to produce compounds that are not naturally synthetized in the host. Recently, the metabolic engineering of microorganisms has produced different unusual fatty acids, such as building block ricinoleic acid and nutraceuticals such as conjugated linoleic acid or polyunsaturated fatty acids. Additionally, microbial sources are preferred hosts for the production of fatty acid-derived compounds such as γ-decalactone, hexanal and dicarboxylic acids. The variety of lipids produced by oleaginous microorganisms is expected to rise in the coming years to cope with the increasing demand.
Delay in seeking help after myocardial infarction increases cardiac damage, study shows
Authors: Susan Mayor
Journal: BMJ (2015)

Delays by patients in recognizing symptoms and seeking medical help after having a myocardial infarction are associated with increased damage to the heart, shows

a study of US patients.1 The study indicates that improvements made by hospitals in reducing the time to treat myocardial infarction can be further improved with increased public awareness about the need for prompt treatment.

The researchers reviewed the records of 2056 patients treated with primary percutaneous coronary intervention (PCI) after having an ST segment elevation …
Epidemiologic characteristics of colon cancer in Asian Indian and Pakistani population living in the USA compared to US White population in SEER database from 1988 to 2002
Authors: A. S. Sehbai, A. Hossain, S. Kurian, J. Abraham
Journal: Journal of Clinical Oncology (2006)

20112 Background: About 1.5% of the US population is South East Asian in origin and it is one of the rapidly growing groups. Colon cancer is the second most common in male and third most common cancer in females in Asian Indian and Pakistani population living in the USA. This is the first study examining the epidemiologic characteristics of colon cancer in this group. Methods: SEER cancer incidence public use database have reported cancer incidence in 13 SEER registries from 1973 to 2002. Since 1988, Indian/Pakistani populations were reported separately under race and ethnicity. Frequency sessions were performed and descriptive parameters were calculated regarding age, sex, stage, grade, tumor location and diagnostic methods used. Results: A total of 4,229 cases of cancer were reported from 1988 to 2002 in this group and 352 (9%) were colon cancers. The reported incidence of colon cancer in SEER database is increasing (11 in 1988 vs. 53 in 2002). Table shows the comparative studies of different variables of colon cancer between Indian/Pakistani and US White population reported in SEER database. Conclusions: Our study shows that the incidence of colon cancer in Asian Indian and Pakistani population under age 50 is substantially higher than the US White population and the predilection is towards the male sex. Our results suggest that this ethnic group warrants close screening and risk factor stratification for earlier detection of colon cancer as well as awareness and counseling in high-risk families. [Table: see text] No significant financial relationships to disclose.
Proto-Oncogene Expression and Proliferative Activity in Human Malignant Gliomas
Authors: Alberto Riccardi, Marco Danova, Monica Giordano, Paolo Gaetani, Giorgio Butti, Carlo Zibera, Giuliano Mazzini
Journal: Neuro-Oncology (1991)

The identification of oncogene products that are highly expressed in malignant glial cells could permit its use both in the diagnosis and in the grading of malignant brain tumors. In this study monoclonal antibodies to the Ha-ras and c-myc gene products (i.e. p21 and p62 oncoprotein respectively) were used in conjunction with flow cytometry (FCM) to characterize and quantitate the oncoprotein expression in 2 human glioblastoma-derived primary cell lines, 5 fresh malignant gliomas and 2 nonneoplastic brain tisue biopsy sample. In these experiments, the levels of the p21 and p62 fluorescence (i.e. Ha-ras and c-myc oncogene expression) in the malignant cultured cells and in the brain tumors samples were more than three times that of the nonneoplastic cells. FCM was also used to relate the quantity of the Ha-ras and c-myc oncoproteins present in the cells to their cell cycle phase. In all neoplastic specimens (which showed diploid DNA content), there was an equal distribution of p21 in G0/ G1, S and G2-M phases of the cell cycle while, the p62 underwent a twofold increase as the cells progresed from G0/G1 to G2-M. The results support the hypotesis of Haras and c-myc activation in human glioblastomas, also, FCM permits a simultaneous examination of the cytokinetic characteristics of tumor cells and oncogene expression, providing a useful tool in the study of molecular biology of brain tumors.
The Role Of Modified Glasgow Prognostic Score As Predictor In Diffuse Large B Cell Lymphoma Treated With The R-CHOP Regimen
Authors: Yundeok Kim, Yu Ri Kim, Soo Jeong Kim, Jang Jieun, Hyun Shin-Young, Hwang Dohyu, Jin Seok Kim, Min Yoo Hong, June-Won Cheong, Lee Jung Hyun
Journal: Blood (2013)
Glucocorticoids downregulate the vasopressin-regulated urea transporter in rat terminal inner medullary collecting ducts.
Authors: M Naruse, J D Klein, Z M Ashkar, J D Jacobs, J M Sands
Journal: Journal of the American Society of Nephrology (1997)

This study tested whether glucocorticoids regulate tubular urea transport. Urea permeability was measured in perfused inner medullary collecting duct (IMCD) subsegments from rats that underwent adrenalectomy, adrenalectomy plus replacement with a physiologic dose of glucocorticoid (dexamethasone), or sham operation. Compared with sham rats, basal urea permeability in terminal IMCD was significantly increased in adrenalectomized rats and reduced in dexamethasone-treated rats. Vasopressin significantly increased urea permeability in all three groups. In contrast, there was no difference in basal or vasopressin-stimulated urea permeability in initial IMCD between the three groups. Next, membrane and vesicle fraction proteins were isolated from inner medullary tip or base and Western analysis was performed by use of an antibody to the rat vasopressin-regulated urea transporter. Vasopressin-regulated urea transporter protein was significantly increased in both membrane and vesicle fractions from the inner medullary tip of adrenalectomized rats. There was no change in vasopressin-regulated urea transporter protein in the inner medullary base, and Northern analysis showed no change in urea transporter mRNA abundance in either inner medullary region. It was concluded that glucocorticoids can downregulate function and expression of the vasopressin-regulated urea transporter in rat terminal IMCD.
Variation at the von Willebrand Factor (vWF) Gene Locus Is Associated With Plasma vWF:Ag Levels: Identification of Three Novel Single Nucleotide Polymorphisms in the vWF Gene Promoter
Authors: Angela M. Keightley, Y. Miu Lam, Jolene N. Brady, Cherie L. Cameron, David Lillicrap
Journal: Blood (1999)
Transplantable Adrenocortical Adenocarcinomas in Osborne-Mendel Rats Fed a Carcinogenic Diet
Authors: A. S. Mulay, W. H. Eyestone
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Transplantable Adrenocortical Adenocarcinomas in Osborne-Mendel Rats Fed a Carcinogenic Diet Get access A. S. Mulay, A. S. Mulay National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. H. Eyestone W. H. Eyestone National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 3, December 1955, Pages 723–739, https://doi.org/10.1093/jnci/16.3.723 Published: 01 December 1955 Article history Received: 06 May 1955 Published: 01 December 1955
Human B-Lymphocyte Antigens Expressed by Lymphocytic and Myelocytic Leukemia Cells. II. Detection by Human Anti-B-Cell Alloantisera2
Authors: Ronald Billing, Alan Ting, Paul I. Terasaki
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Human B-Lymphocyte Antigens Expressed by Lymphocytic and Myelocytic Leukemia Cells. II. Detection by Human Anti-B-Cell Alloantisera Get access Ronald Billing, Ronald Billing Search for other works by this author on: Oxford Academic PubMed Google Scholar Alan Ting, Alan Ting Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul I. Terasaki Paul I. Terasaki Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 58, Issue 2, February 1977, Pages 199–203, https://doi.org/10.1093/jnci/58.2.199 Published: 01 February 1977 Article history Received: 18 March 1976 Accepted: 16 July 1976 Published: 01 February 1977
Response to Letter Regarding Article, “Renal Dysfunction as a Predictor of Stroke and Systemic Embolism in Patients With Nonvalvular Atrial Fibrillation: Validation of the R <sub>2</sub> CHADS <sub>2</sub> Index in the ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study Cohorts”
Authors: Jonathan P. Piccini, Susanna R. Stevens, YuChiao Chang, Daniel E. Singer, Yuliya Lokhnygina, Alan S. Go, Manesh R. Patel, Kenneth W. Mahaffey, Jonathan L. Halperin, Günter Breithardt, Graeme J. Hankey, Werner Hacke, Richard C. Becker, Christopher C. Nessel, Keith A. A. Fox, Robert M. Califf
Journal: Circulation (2013)

We appreciate the comments and suggestions made by Apostolakis et al.As they point out, there are several important limitations of our analysis, 1 including the high-risk nature of the ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) trial cohort. 2 Factors associated with stroke or systemic embolism in a selected high-risk population may not be generalizable to other patient populations, including patients not currently being treated with oral anticoagulation.It was for precisely these reasons that we validated our model in the independent and unselected ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) cohort.In our external validation analyses, we found that use of the R 2 CHADS 2 score improved risk stratification in the ATRIA cohort.When compared with the CHADS 2 index, use of the R 2 CHADS 2 resulted in 12% (95% confidence interval, 6% to 19.5%) net reclassification improvement in patients on warfarin.Net reclassification improvement was even more robust in those not receiving oral anticoagulation (net reclassification improvement, 22.6%; 95% confidence interval, 14.5% to 30.7%).Additional analyses from ATRIA have also supported the importance of renal function in risk stratification for stroke. 3 Although we certainly agree that additional validation is warranted, the data from ROCKET AF and ATRIA indicate that stroke risk stratification in patients with atrial fibrillation should include renal function.
Five-year Oncologic Outcomes After Transperitoneal Robotic Partial Nephrectomy for Renal Cell Carcinoma
Authors: Hiury S. Andrade, Homayoun Zargar, Peter A. Caputo, Oktay Akca, Onder Kara, Daniel Ramirez, Georges-Pascal Haber, Robert J. Stein, Jihad H. Kaouk
Journal: European Urology (2015)
Young people should be educated about the dangers of temporary tattoos
Authors: Josef Panasoff
Journal: BMJ (2015)

Although some "black henna" tattoos do not contain henna, most do. 1 The problem is that they all contain the very potent contact allergen paraphenylenediamine (PPD). 2 The concentration of PDD in hair dyes is <2% but in the black henna mixture it is much higher-7% or more. 3 The combination of high concentration and high allergenic potency has led to a near epidemic of allergic reactions to PPD in young people, who dye their hair at young ages for fashion rather than for covering white hair. 4 5They first react to black henna tattoos and subsequently to hair dyes.Because this is a lifelong allergy the only solution is prevention.Young people (and their parents) should be educated about the dangers of temporary tattoos.
Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells
Authors: Adam Blaisdell, Amandine Crequer, Devin Columbus, Takiko Daikoku, Khush Mittal, Sudhansu K. Dey, Adrian Erlebacher
Journal: Cancer Cell (2015)

Highlights•PMNs slow tumor growth and malignant progression in PTEN-deficient uterine tumors•PMNs reduce tumor burden by promoting tumor cell basement membrane detachment•Anti-tumor PMN activity does not require other leukocytes or tumor cell senescence•PMN recruitment to early-stage tumors is linked to hypoxia-induced inflammationSummaryPolymorphonuclear neutrophils (PMNs) are largely considered to foster cancer development despite wielding an arsenal of cytotoxic agents. Using a mouse model of PTEN-deficient uterine cancer, we describe a surprising inhibitory role for PMNs in epithelial carcinogenesis. By inducing tumor cell detachment from the basement membrane, PMNs impeded early-stage tumor growth and retarded malignant progression. Unexpectedly, PMN recruitment and tumor growth control occurred independently of lymphocytes and cellular senescence and instead ensued as part of the tumor's intrinsic inflammatory response to hypoxia. In humans, a PMN gene signature correlated with improved survival in several cancer subtypes, including PTEN-deficient uterine cancer. These findings provide insight into tumor-associated PMNs and reveal a context-specific capacity for PMNs to directly combat tumorigenesis.Graphical abstract
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms
Authors: Jasper Mullenders, Beatriz Aranda-Orgilles, Priscillia Lhoumaud, Matthew Keller, Juhee Pae, Kun Wang, Clarisse Kayembe, Pedro P. Rocha, Ramya Raviram, Yixiao Gong, Prem K. Premsrirut, Aristotelis Tsirigos, Richard Bonneau, Jane A. Skok, Luisa Cimmino, Daniela Hoehn, Iannis Aifantis
Journal: The Journal of Experimental Medicine (2015)

The cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins) is critically important for proper sister chromatid separation during mitosis. Mutations in the cohesin complex were recently identified in a variety of human malignancies including acute myeloid leukemia (AML). To address the potential tumor-suppressive function of cohesin in vivo, we generated a series of shRNA mouse models in which endogenous cohesin can be silenced inducibly. Notably, silencing of cohesin complex members did not have a deleterious effect on cell viability. Furthermore, knockdown of cohesin led to gain of replating capacity of mouse hematopoietic progenitor cells. However, cohesin silencing in vivo rapidly altered stem cells homeostasis and myelopoiesis. Likewise, we found widespread changes in chromatin accessibility and expression of genes involved in myelomonocytic maturation and differentiation. Finally, aged cohesin knockdown mice developed a clinical picture closely resembling myeloproliferative disorders/neoplasms (MPNs), including varying degrees of extramedullary hematopoiesis (myeloid metaplasia) and splenomegaly. Our results represent the first successful demonstration of a tumor suppressor function for the cohesin complex, while also confirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potential development of a myeloid malignancy.
Vandetanib with mFOLFOX6 in advanced colorectal adenocarcinoma: An open-label, multicenter phase I study
Authors: M. Michael, N. Tebbutt, P. Gibbs, R. Smith, A. Godwood, S. Oliver
Journal: Journal of Clinical Oncology (2007)

4095 Background: Vandetanib (ZD6474) is a once-daily oral anticancer agent that selectively inhibits VEGFR- dependent tumor angiogenesis, and EGFR- and RET-dependent tumor cell proliferation. The primary objective of this Phase I study was to establish the safety and tolerability of the vandetanib + mFOLFOX6 combination in patients with metastatic colorectal cancer (CRC). Secondary objectives included an assessment of pharmacokinetic (PK) interactions between vandetanib and mFOLFOX6, and preliminary evaluation of efficacy (RECIST). Methods: Patients with CRC who were eligible for 1 st - or 2 nd -line chemotherapy received once-daily oral doses of vandetanib (100 mg) plus standard 14-day treatment cycles of mFOLFOX6 (oxaliplatin 85 mg/m 2 and leucovorin 400 mg/m 2 2-hr IV; 5-fluorouracil [5-FU] 400 mg/mg 2 IV bolus and 5-FU 2400 mg/m 2 46-hr IV). If &lt;2 of 6 evaluable patients (ie, having completed 6 weeks of vandetanib treatment with associated mFOLFOX6 cycles) experienced a vandetanib-related dose-limiting toxicity (DLT), an additional cohort received vandetanib 300 mg + mFOLFOX6. Results: Seventeen patients (12 male/5 female; 7 1 st -line/10 2 nd -line; mean age 61 years, range 48–75) received vandetanib 100 mg (n=9) or 300 mg (n=8) + mFOLFOX6; the median number of oxaliplatin cycles was 8. Two DLTs were reported: one patient receiving 100 mg vandetanib developed diarrhea (CTC grade 2), dehydration, electrolyte imbalance and QTc prolongation, and one patient receiving vandetanib 300 mg developed diarrhea (grade 3) that responded to dose reduction. Common adverse events (AEs), irrespective of grade, were diarrhea, nausea, lethargy (all n=11), neutropenia and peripheral neuropathy (both n=10); AEs =grade 3 reported in more than one patient were diarrhea (n=4, all grade 3) and neutropenia (n=5, grade 3; n=2, grade 4). There was no apparent PK interaction between vandetanib and oxaliplatin or 5-FU. Best overall responses in the 14 patients evaluable for efficacy were partial response (n=3), stable disease =8 weeks (n=8), and progressive disease (n=3). Conclusions: In patients with advanced CRC, combining once-daily vandetanib (100 or 300 mg) with mFOLFOX6 was generally well tolerated. ZACTIMA is a trademark of the AstraZeneca group of companies No significant financial relationships to disclose.