tbuckley/cabot-search huggingface dataset:
Factors Influencing Survival in Children with Chronic Interstitial Lung Disease
Authors: LELAND L. FAN, CLAUDIA A. KOZINETZ
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

To investigate factors influencing survival in children with chronic interstitial lung disease (ILD), we extracted specific clinical information from a data base of 99 children with ILD who met entry criteria for our study. The effects of a weight below the fifth percentile for the patient's age, crackles, clubbing, family history of ILD, symptom duration, and severity-of-illness score on survival were examined with univariate and multivariate statistical analyses. There were 15 recorded deaths in the group, with a probability that a patient would survive to 24 mo, 48 mo, and 60 mo after onset of symptoms of 83%, 72%, and 64%, respectively. Of the clinical features, only increasing severity-of-illness score was significantly associated with a higher probability of decreased survival. Children with ILD have decreased survival probabilities that can be predicted with a severity-of-illness score.
Pharyngeal mesoderm development during embryogenesis: implications for both heart and head myogenesis
Authors: E. Tzahor, S. M. Evans
Journal: Cardiovascular Research (2011)

The pharyngeal mesoderm (PM), located in the head region of the developing embryo, recently triggered renewed interest as the major source of cells contributing to broad regions of the heart as well as to the head musculature. What exactly is PM? In this review, we describe the anatomical and molecular characteristics of this mesodermal population and its relationship to the first and second heart fields in chick and mouse embryos. The regulatory network of transcription factors and signalling molecules that regulate PM development is also discussed. In addition, we summarize recent studies into the evolutionary origins of this tissue and its multipotential contributions to both cardiac and pharyngeal muscle progenitors.
Sleep-related breathing disorders. 4. Consequences of sleep disordered breathing.
Authors: K A Ferguson, J A Fleetham
Journal: Thorax (1995)

Sleep disordered breathing is common and may affect up to 24% of men and 9% of women.'There is a continuum in sleep disordered breathing associated with progressively more clinical consequences, from chronic snoring to obstructive sleep hypopnea to severe ob- structive sleep apnoea (OSA).Although certain manifestations of sleep disordered breathing have been described for many years, a wider recognition of the clinical consequences has only occurred in the last decade.Sleep dis- ordered breathing is characterised by recurrent upper airways obstruction which results in episodic asphyxia and interruption of the normal sleep pattern.The clinical consequences of sleep disordered breathing are quite diverse and are usually caused by either the recurrent asphyxia or sleep fragmentation (fig 1). Cardiac consequences SYSTEMIC HYPERTENSIONSystemic blood pressure normally decreases by 5-14% in non-rapid eye movement (non- REM) sleep compared with awake resting
Analysis of T cell signaling by class I MHC molecules: the cytoplasmic domain is not required for signal transduction.
Authors: H Gur, F el-Zaatari, T D Geppert, M C Wacholtz, J D Taurog, P E Lipsky
Journal: The Journal of Experimental Medicine (1990)

The structural requirements for signal transduction by class I major histocompatibility complex (MHC) molecules were examined. Native or mutant HLA-A2 or HLA-B27 constructs lacking most of their cytoplasmic domains were co-transfected with pSV2neo into Jurkat cells. Transfection of either native or mutant constructs resulted in a comparable expression of the gene products. Stimulation of transfectants expressing either native or truncated A2 or B27 molecules with specific mAb evoked an increase in [Ca2+]i upon crosslinking. Moreover, crosslinking native or truncated A2 or B27 induced IL-2 production upon co-stimulation with phorbol myristate acetate. These results confirm that crosslinking class I MHC molecules transduces an activation signal to human T cells. Effective signaling was observed when all but four of the intracytoplasmic residues were deleted, indicating that signal transduction does not require this portion of the molecule.
Discrepancies between observed and predicted continuous venovenous hemofiltration removal of antimicrobial agents in critically ill patients and the effects on dosing
Authors: Catherine S. C. Bouman, Hendrikus J. M. van Kan, Richard P. Koopmans, Johanna C. Korevaar, Marcus J. Schultz, Margreeth B. Vroom
Journal: Intensive Care Medicine (2006)
Analysis of the electrophysiological properties and arrhythmias in directly contacted skeletal and cardiac muscle cell sheets
Authors: Y ITABASHI, S MIYOSHI, S YUASA, J FUJITA, T SHIMIZU, T OKANO, K FUKUDA, S OGAWA
Journal: Cardiovascular Research (2005)

Autologous skeletal muscle cell (SM) transplantation into the in vivo heart sometimes induces serious arrhythmias. The purpose of this study was to investigate the electrophysiology of cardiomyocyte (CM) and SM in direct contact and to study the mechanism underlying the cause of arrhythmia using the recently developed cell sheet engineering technique.Primary cultured rat neonatal SM and CM were prepared, and cell sheets were fabricated using temperature-responsive culture dishes. The action potential was recorded by a conventional microelectrode. Intracellular calcium concentration and optical mapping image of the action potential were recorded using Fluo-3 and di-4-ANEPPS, respectively. A video motion-detecting system was used for the detection of arrhythmias.SM myotubes occasionally displayed automaticity. SM sheets did not display synchronized contraction, but instead groups of myotubes contracted independently. The action potential of SM, induced by artificial pacing, did not expand to the entire sheet but was limited within a restricted, small area around the electrode, and it was unfeasible to generate an electrical connection or propagate an action potential between CM and SM sheets. SM sheets, in which some of the myotubes displayed automaticity, caused fibrillation-like contraction in the co-cultured CM sheets, and this arrhythmia was specifically blocked by the stretch-activated channel blocker GsMTx-4.These findings show that SM sheets do not contract synchronously or generate functional syncytia with the surrounding CM sheets and that stretch-induced arrhythmias due to spontaneous contraction of SM may occur in the CM sheet.
Breast Cancer in Men
Authors: M. Gethins
Journal: JNCI Journal of the National Cancer Institute (2012)

One of the rarest cancers in men, breast cancer occurs approximately 100 times less than in women. The lifetime risk of having breast cancer is 1 in 1,000 for men, and incidence has remained relatively stable over the past 30 years. Whereas in the past, the prognosis for men with breast cancer was thought to be worse than for women, recent research has found little difference in outcomes. But awareness, research, and treatments pose challenges for these patients. Because of disease rarity and recruitment diffi culties, studies tend to be small, and recent research shows that breast cancer in men may require sex-specifi c drug regimens.
Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1–dependent leukocyte recruitment in vivo
Authors: Daxin Chen, Adam Carpenter, Joel Abrahams, Rachel C. Chambers, Robert I. Lechler, John H. McVey, Anthony Dorling
Journal: The Journal of Experimental Medicine (2008)

Thrombin, acting through a family of protease-activated receptors (PARs), is known to amplify inflammatory responses, but the in vivo importance of PARs in inflammation is not fully appreciated. In a mouse heart-to-rat transplant model, where it is possible to distinguish graft (mouse) from systemic (rat) chemokines, we show that donor PAR-1 is required to generate the local monocyte chemoattractant protein (MCP)-1 needed to recruit rat natural killer cells and macrophages into the hearts. We have confirmed the importance of this mechanism in a second model of thioglycollate-induced peritonitis and also show that PAR-1 is important for the production of MCP-3 and MCP-5. Despite the presence of multiple other mediators capable of stimulating chemokine production in these models, these data provide the first evidence that thrombin and PAR activation are required in vivo to initiate inflammatory cell recruitment.
Epidemiology of acne in the general population: the risk of smoking
Authors: T. Schafer, A. Nienhaus, D. Vieluf, J. Berger, J. Ring
Journal: British Journal of Dermatology (2001)

Journal Article Epidemiology of acne in the general population: the risk of smoking Get access T. Schäfer, T. Schäfer Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Straße 29, 80802 Munich, Germany Dr Torsten Schäfer. E‐mail: tschafer@lrz.tum.de Search for other works by this author on: Oxford Academic Google Scholar A. Nienhaus, A. Nienhaus Institute of Mathematics and Computer Science in Medicine, Universitätsklinikum Hamburg‐Eppendorf, University of Hamburg, Martinistraße 52, 20246 Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar D. Vieluf, D. Vieluf Fachklinikum Borkum (Zentrum für Dermatologie, Allergologie, Pädiatrie und Umweltmedizin), Jann‐Berghaus‐Straße 49, 26757 Borkum, Germany Search for other works by this author on: Oxford Academic Google Scholar J. Berger, J. Berger Institute of Mathematics and Computer Science in Medicine, Universitätsklinikum Hamburg‐Eppendorf, University of Hamburg, Martinistraße 52, 20246 Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar J. Ring J. Ring Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Straße 29, 80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 1, 1 July 2001, Pages 100–104, https://doi.org/10.1046/j.1365-2133.2001.04290.x Published: 01 July 2001
Does This Study Make My Aorta Look Fat?
Authors: Scott Kinlay
Journal: Circulation (2015)

A trip to the mall can rapidly become a nightmare with the question "Does this [garment] make my [anatomic part] look fat?"An affirmative answer risks grueling days in the doghouse.A negative answer invites intense scrutiny for evidence of insincerity.Diplomacy dictates a measured approach of watchful waiting, preferably from a safe distance out of earshot.
CD8 naive T cell counts decrease progressively in HIV-infected adults.
Authors: M Roederer, J G Dubs, M T Anderson, P A Raju, L A Herzenberg, L A Herzenberg
Journal: Journal of Clinical Investigation (1995)

We show here that CD8 naive T cells are depleted during the asymptomatic stage of HIV infection. Although overall CD8 T cell numbers are increased during this stage, the naive CD8 T cells are progressively lost and fall in parallel with overall CD4 T cell counts. In addition, we show that naive CD4 T cells are preferentially lost as total CD4 cell counts fall. These findings, presented here for adults, and in the accompanying study for children, represent the first demonstration that HIV disease involves the loss of both CD4 T cells and CD8 T cells. Furthermore, they provide a new insight into the mechanisms underlying the immunodeficiency of HIV-infected individuals, since naive T cells are required for all new T cell-mediated immune responses. Studies presented here also show that the well-known increase in total CD8 counts in most HIV-infected individuals is primarily due to an expansion of memory cells. Thus, memory CD8 T cells comprise over 80% of the T cells in PBMC from individuals with < 200 CD4/microliter, whereas they comprise roughly 15% in uninfected individuals. Since the naive and memory subsets have very different functional activities, this altered naive/memory T cell representation has significant consequences for the interpretation of data from in vitro functional studies.
The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway.
Authors: K Pazdrak, D Schreiber, P Forsythe, L Justement, R Alam
Journal: The Journal of Experimental Medicine (1995)

Interleukin 5 (IL-5) regulates the growth and function of eosinophils. The objective of this study was to investigate the intracellular signal transduction mechanism of IL-5 in eosinophils. Purified eosinophils were stimulated with IL-5, and the involvement of various kinases was investigated by immunoblotting, immune complex kinase assay, and in situ denatured/renatured kinase assay. We found that IL-5 induced tyrosine phosphorylation and activation of a number of kinases. Two species of lyn kinases (53 and 56 kD) were present in eosinophils. Both forms were Tyr-phosphorylated and activated rapidly within 1 min. Further, lyn kinase was physically associated with the IL-5 beta receptor in eosinophils. Ras was studied by immunoprecipitation followed by thin-layer chromatography. Ras bound higher quantities of [alpha-32P]guanosine 5'triphosphate upon stimulation with IL-5. Raf-1 kinase showed increased Tyr phosphorylation on immunoblotting and increased activity in the immune complex kinase assay. Two species of MEK (MAP or Erk kinase) (41 and 45 kD) were identified in eosinophils, which underwent autophosphorylation upon stimulation. Microtubule-associated protein (MAP) kinase (p44) was Tyr-phosphorylated on immunoblotting and had increased activity in the immune-complex kinase assay. MAP kinases were also studied after metabolic radiolabeling of the cells with [32P]orthophosphates. IL-5 stimulated phosphorylation of MAP kinases in situ. Thus, we have delineated major components of an important signaling pathway in eosinophils. We believe that one of the signals generated by IL-5 receptor activation is propagated through the lyn-Ras-Raf-1-MEK-MAP kinase pathway.
Bevacizumab-Induced Normalization of Blood Vessels in Tumors Hampers Antibody Uptake
Authors: Marlous Arjaans, Thijs H. Oude Munnink, Sjoukje F. Oosting, Anton G.T. Terwisscha van Scheltinga, Jourik A. Gietema, Erik T. Garbacik, Hetty Timmer-Bosscha, Marjolijn N. Lub-de Hooge, Carolina P. Schröder, Elisabeth G.E. de Vries
Journal: Cancer Research (2013)

In solid tumors, angiogenesis occurs in the setting of a defective vasculature and impaired lymphatic drainage that is associated with increased vascular permeability and enhanced tumor permeability. These universal aspects of the tumor microenvironment can have a marked influence on intratumoral drug delivery that may often be underappreciated. In this study, we investigated the effect of blood vessel normalization in tumors by the antiangiogenic drug bevacizumab on antibody uptake by tumors. In mouse xenograft models of human ovarian and esophageal cancer (SKOV-3 and OE19), we evaluated antibody uptake in tumors by positron emission tomographic imaging 24 and 144 hours after injection of (89)Zr-trastuzumab (SKOV-3 and OE19), (89)Zr-bevacizumab (SKOV-3), or (89)Zr-IgG (SKOV-3) before or after treatment with bevacizumab. Intratumor distribution was assessed by fluorescence microscopy along with mean vessel density (MVD) and vessel normalization. Notably, bevacizumab treatment decreased tumor uptake and intratumoral accumulation compared with baseline in the tumor models relative to controls. Bevacizumab treatment also reduced MVD in tumors and increased vessel pericyte coverage. These findings are clinically important, suggesting caution in designing combinatorial trials with therapeutic antibodies due to a possible reduction in tumoral accumulation that may be caused by bevacizumab cotreatment.
Bisphosphonate therapy of reflex sympathetic dystrophy syndrome
Authors: S Adami, V Fossaluzza, D Gatti, E Fracassi, V Braga
Journal: Annals of the Rheumatic Diseases (1997)

<h3>OBJECTIVE</h3> The reflex sympathetic dystrophy syndrome (RSDS) is a painful limb disorder, for which a consistently effective treatment has not yet been identified. The disease is associated with increased bone resorption and patchy osteoporosis, which might benefit from treatment with bisphosphonates, powerful inhibitors of bone resorption. <h3>METHODS</h3> Twenty patients with RSDS of foot and hand, were randomly assigned to blind administration of either alendronate intravenously (Istituto Gentili, Pisa, Italy) 7.5 mg dissolved in 250 ml saline solution or placebo saline infusions daily for three days. Two weeks later all patients had an identical treatment course with open labelled alendronate (7.5 mg/day for three days), independent from the results of the first blind treatment. <h3>RESULTS</h3> In the patients treated with blind alendronate the diminution in spontaneous pain, tenderness, and swelling (circumference of the affected limb) and the improvement in motion were significantly different from baseline (p&lt;0.001), from those observed within the first two weeks in the control group (p&lt;0.01), and from week 2 to week 4 (p&lt;0.01). In the patients given blind placebo infusions no relevant symptomatic changes were observed after the first two weeks of follow up, but they responded to the open alendronate therapy given afterwards. In 12 patients with RSDS of the hand the ultradistal bone mineral content (BMC) of the affected arm was considerably lower than that of the controlateral arm (mean (SD)) (426(82) mg/cm versus 688(49)). Six weeks after the beginning of the trial BMC rose by 77(12) mg/cm (p&lt;0.001) in the affected arm, but it did not change in the controlateral. <h3>CONCLUSIONS</h3> These results indicate that bisphosphonates should be considered for the treatment of RSDS, producing consistent and rapid remission of the disease.
Mechanisms for polycyclic aromatic hydrocarbon degradation by ligninolytic fungi.
Authors: K E Hammel
Journal: Environmental Health Perspectives (1995)

Ligninolytic fungi accomplish the partial degradation of numerous aromatic organopollutants. Their ability to degrade polycyclic aromatic hydrocarbons (PAHs) is particularly interesting because eukaryotes were previously considered to be unable to cleave fused-ring aromatics. Recent results indicate that extracellular peroxidases of these fungi are responsible for the initial oxidation of PAHs. Fungal lignin peroxidases oxidize certain PAHs directly, whereas fungal manganese peroxidases co-oxidize them indirectly during enzyme-mediated lipid peroxidation.
Use of signals in the terminal QRS complex to identify patients with ventricular tachycardia after myocardial infarction.
Authors: M B Simson
Journal: Circulation (1981)

Small, high-frequency electrocardiographic signals were recorded from the body surface in 39 patients with and 27 patients without ventricular tachycardia (VT). All patients were in normal sinus rhythm, had a previous myocardial infarction, were not taking antiarrhythmic drugs, and did not have bundle branch block. Bipolar X, Y, Z leads were signal averaged and processed by a bidirectional digital filter that allowed low-amplitude signals to be detected in the terminal QRS complex and ST segment. The high-pass filter frequency was 25 Hz. Patients with VT had a lower amplitude of high-frequency signal in the late QRS complex. In the last 40 msec of the filtered QRS complex, the patients with VT had 14.9 +/- 14.4 microV of high-frequency signal; patients without VT had 73.8 +/- 47.7 microV (p less than 0.0001). Ninety-two percent of the patients with VT had less than 25 microV of high-frequency voltage; only 7% of patients without VT had less than 25 microV (p less than 0.0001). Patients with VT had a longer QRS duration than those without VT, 139 +/- 26 vs 95 +/- 10 msec (p less than 0.0001). The QRS duration was longer than 120 msec in 72% of the patients with VT but in none of the patients without VT (p less than 0.0001). In all patients there was no separate and discrete high-frequency signal in the ST segment. Advanced signal processing of the ECG accurately identified the patients in the study with VT after myocardial infarction.
Identification and immunolocalisation of annexins V and VI, the major cardiac annexins, in rat heart
Authors: A. F Doubell, C. Lazure, C. Charbonneau, G. Thibault
Journal: Cardiovascular Research (1993)

Journal Article Identification and immunolocalisation of annexins V and VI, the major cardiac annexins, in rat heart Get access Anton F Doubell, Anton F Doubell Laboratory of Cell Biology of Hypertension, Clinical Research Institute of Montreal and Department of Medicine, University of Montreal: C Charbonneau, G Thibault; Department of Internal Medicine, Faculty of Medicine, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, South Africa: A F Doubell; J A de Seve Laboratory of Molecular Neuroendocrinology, Clinical Research Institute of Montreal: C Lazure. Correspondence to Dr Doubell. Search for other works by this author on: Oxford Academic PubMed Google Scholar Claude Lazure, Claude Lazure Laboratory of Cell Biology of Hypertension, Clinical Research Institute of Montreal and Department of Medicine, University of Montreal: C Charbonneau, G Thibault; Department of Internal Medicine, Faculty of Medicine, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, South Africa: A F Doubell; J A de Seve Laboratory of Molecular Neuroendocrinology, Clinical Research Institute of Montreal: C Lazure. Search for other works by this author on: Oxford Academic PubMed Google Scholar Christian Charbonneau, Christian Charbonneau Laboratory of Cell Biology of Hypertension, Clinical Research Institute of Montreal and Department of Medicine, University of Montreal: C Charbonneau, G Thibault; Department of Internal Medicine, Faculty of Medicine, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, South Africa: A F Doubell; J A de Seve Laboratory of Molecular Neuroendocrinology, Clinical Research Institute of Montreal: C Lazure. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gaétan Thibault Gaétan Thibault Laboratory of Cell Biology of Hypertension, Clinical Research Institute of Montreal and Department of Medicine, University of Montreal: C Charbonneau, G Thibault; Department of Internal Medicine, Faculty of Medicine, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, South Africa: A F Doubell; J A de Seve Laboratory of Molecular Neuroendocrinology, Clinical Research Institute of Montreal: C Lazure. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 7, July 1993, Pages 1359–1367, https://doi.org/10.1093/cvr/27.7.1359 Published: 01 July 1993 Article history Received: 24 November 1992 Accepted: 15 February 1993 Published: 01 July 1993