tbuckley/cabot-search huggingface dataset:
Women in Psychiatry: Personal Perspectivesedited by NorrisDonna M., M.D., JayaramGeetha, M.D., M.B.A., and PrimmAnnelle B., M.D., M.P.H. Washington, DC, American Psychiatric Publishing, 2012, 345 pp., $65.00.
Authors: Mary Anne Badaracco
Journal: American Journal of Psychiatry (2012)
Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization
Authors: Carina Fischer, Katharina Leithner, Christoph Wohlkoenig, Franz Quehenberger, Alexandra Bertsch, Andrea Olschewski, Horst Olschewski, Andelko Hrzenjak
Journal: Molecular Cancer (2015)

Lung cancer is one of the most frequent cancer types and the leading cause of cancer death worldwide. Cisplatin is a widely used chemotherapeutic for non-small cell lung carcinoma (NSCLC), however, its positive effects are diminished under hypoxia. We wanted to determine if co-treatment with cisplatin and histone deacetalyse (HDAC) inhibitor panobinostat can reduce hypoxia-induced cisplatin resistance in NSCLC cells, and to elucidate mechanism involved.Expression status of different HDACS was determined in two cell lines and in tumor tissue from 20 patients. Cells were treated with cisplatin, panobinostat, or with combination of both under normoxic and hypoxic (1% O(2)) conditions. Cell cycle, viability, acetylation of histones, and activation of apoptosis were determined. HIF-1α stability and its interaction with HDAC4 were analyzed.Most class I and II HDACs were expressed in NSCLC cells and tumor samples. Co-treatment of tumor cells with cisplatin and panobinostat decreased cell viability and increased apoptosis more efficiently than in primary, non-malignant bronchial epithelial cells. Co-treatment induced apoptosis by causing chromatin fragmentation, activation of caspases-3 and 7 and PARP cleavage. Toxic effects were more pronounced under hypoxic conditions. Co-treatment resulted in destabilization and degradation of HIF-1α and HDAC4, a protein responsible for acetylation and de/stabilization of HIF-1α. Direct interaction between HDAC4 and HIF-1α proteins in H23 cells was detected.Here we show that hypoxia-induced cisplatin resistance can be overcome by combining cisplatin with panobinostat, a potent HDAC inhibitor. These findings may contribute to the development of a new therapeutic strategy for NSCLC.
Requirements for medications commonly used in the treatment of allergic rhinitis
Authors: Jean Bousquet, Paul Van Cauwenberge, None Members, Claus Bachert, Giorgio W Canonica, Pascal Demoly, Stephen R Durham, Wystske Fokkens, Richard Lockey, Eli O Meltzer, Joaquim Mullol, Robert M Naclerio, David Price, F Estelle R Simons, Antonio M Vignola, John O Warner
Journal: Allergy (2003)
Hepatic overexpression of bovine scavenger receptor type I in transgenic mice prevents diet-induced hyperbetalipoproteinemia.
Authors: S Wölle, D P Via, L Chan, J A Cornicelli, C L Bisgaier
Journal: Journal of Clinical Investigation (1995)

Hepatic scavenger receptors (SR) may play a protective role by clearing modified lipoproteins before they target the artery wall. To gain insight into this hypothesized function, transgenic mice expressing hepatic bovine SR (TgSR) were created and studied when fed chow, and during diet-induced hyperlipidemia. SR overexpression resulted in extensive hepatic parenchymal cell uptake of fluorescently labeled acetylated human low density lipoprotein (DiI ac-hLDL) and a twofold increase in 125I-acetylated-LDL clearance. Food intake and cholesterol absorption was indistinguishable between control and TgSR mice. In chow-fed mice, lipoprotein cholesterol was similar in control and TgSR mice. However, on a 3-wk high fat/cholesterol (HFHC) diet, the rise in apoB containing lipoproteins was suppressed in TgSR+/- and TgSR+/+ mice. The rise in HDL was similar in control and TgSR+/- mice, but significantly elevated in the TgSR+/+ mice. Overall, on chow, the ratio of apo-B containing lipoprotein cholesterol to HDL cholesterol was similar for all groups (control = 0.33; TgSR+/- = 0.32; TgSR+/+ = 0.38). However, after 3 wk on the HFHC diet, this ratio was markedly higher in control (2.34 +/- 0.21) than in either TgSR+/- (1.00 +/- 0.24) or TgSR+/+ (1.00 +/- 0.19) mice. In TgSR+/- mice, hepatic cholesteryl esters were reduced by 59%, 7 alpha-hydroxylase mRNA levels were elevated twofold, and a significant increase in fecal bile acid flux was observed after the 3-wk HFHC diet. These results suggest SR may play a protective role in liver by preventing diet-induced increases in apoB containing lipoproteins.
Portal venous injection in the rat
Authors: L. H. Blumgart, K. G. Leach, M. S. F. McLachlan, S. Seager, C. J. Ryan
Journal: Gut (1971)

A technique for subcutaneous transposition of the spleen in the rat is described. The preparation has been developed as a reliable means of transplenic portal injection. It has been shown that different substances injected into the pulp of the transposed spleen are cleared and not pooled in the organ. The development of porta-systemic venous communications has been demonstrated and their detection radiologically and by isotope techniques is illustrated. It is suggested that the technique outlined in this communication may be of value in the study of the portal circulation, the function of the liver, and in the investigation of drug action. If adequate porta-systemic venous connexions are present the portal vein can be tied above its splenic tributary and the animal will survive. The method offers a simple means of porta-systemic diversion in the rat.
Particulate Matter Air Pollution Exposure, Distance to Road, and Incident Lung Cancer in the Nurses’ Health Study Cohort
Authors: Robin C. Puett, Jaime E. Hart, Jeff D. Yanosky, Donna Spiegelman, Molin Wang, Jared A. Fisher, Biling Hong, Francine Laden
Journal: Environmental Health Perspectives (2014)

A body of literature has suggested an elevated risk of lung cancer associated with particulate matter and traffic-related pollutants.We examined the relation of lung cancer incidence with long-term residential exposures to ambient particulate matter and residential distance to roadway, as a proxy for traffic-related exposures.For participants in the Nurses' Health Study, a nationwide prospective cohort of women, we estimated 72-month average exposures to PM2.5, PM2.5-10, and PM10 and residential distance to road. Follow-up for incident cases of lung cancer occurred from 1994 through 2010. Cox proportional hazards models were adjusted for potential confounders. Effect modification by smoking status was examined.During 1,510,027 person-years, 2,155 incident cases of lung cancer were observed among 103,650 participants. In fully adjusted models, a 10-μg/m3 increase in 72-month average PM10 [hazard ratio (HR) = 1.04; 95% CI: 0.95, 1.14], PM2.5 (HR = 1.06; 95% CI: 0.91, 1.25), or PM2.5-10 (HR = 1.05; 95% CI: 0.92, 1.20) was positively associated with lung cancer. When the cohort was restricted to never-smokers and to former smokers who had quit at least 10 years before, the associations appeared to increase and were strongest for PM2.5 (PM10: HR = 1.15; 95% CI: 1.00, 1.32; PM2.5: HR = 1.37; 95% CI: 1.06, 1.77; PM2.5-10: HR = 1.11; 95% CI: 0.90, 1.37). RESULTS were most elevated when restricted to the most prevalent subtype, adenocarcinomas. Risks with roadway proximity were less consistent.Our findings support those from other studies indicating increased risk of incident lung cancer associated with ambient PM exposures, especially among never- and long-term former smokers.
Intestinal Obstruction as a Late Complication of Fibrocystic Disease of the Pancreas
Authors: E. L. Birse
Journal: BMJ (1956)

said to be fatal except in hepatic cirrhosis (Thole, 1939).A vein graft may not be immediately available to repair such defects of the vein wall.Operating upon dogs, Csillag et al. (1953) have successfully repaired 20-mm.defects of the portal vein by suturing a serosal covered loop of bowel over the defect.They think that this method may be life-saving in cases of traumatic defects of the great abdominal veins in humans.
The effect of short-term immunotherapy with molecular standardized grass and rye allergens on eosinophil cationic protein and tryptase in nasal secretions
Authors: Ludger Klimek, Hendrik Wolf, Torsten Mewes, Dirk Dormann, Angelika Reske-Kunz, Jörg Schnitker, Wolf Mann
Journal: Journal of Allergy and Clinical Immunology (1999)
High Pseudomonas aeruginosa acquisition rate in CF
Authors: B E van Ewijk
Journal: Thorax (2006)

Chronic colonisation of the lungs with Pseudomonas aeruginosa in patients with cystic fibrosis (CF) is associated with reduced lung function and life expectancy. Prevention of chronic colonisation might be achieved by avoidance of, or early and aggressive treatment of, primary P aeruginosa acquisition.1 Segregation of uninfected indivduals from chronically P aeruginosa colonised CF patients is advocated to prevent cross infection.2 As surveillance studies suggest that the airways of healthy children are rarely colonised with P aeruginosa ,3 healthy individuals are not regarded as a potential source of P aeruginosa acquisition. In addition, it has been shown that acquisition of P aeruginosa in CF patients is often preceded by a viral respiratory infection.4 We hypothesised that the incidence of P aeruginosa acquisition during periods of acute respiratory infections (ARI) is equal in both healthy and CF individuals, and considerably exceeds the prevalence in …
Polyclonality of BRAF Mutations in Acquired Melanocytic Nevi
Authors: Jingrong Lin, Minoru Takata, Hiroshi Murata, Yasufumi Goto, Kenji Kido, Soldano Ferrone, Toshiaki Saida
Journal: JNCI Journal of the National Cancer Institute (2009)

Melanocytic nevi are thought to be senescent clones of melanocytes that have acquired an oncogenic BRAF mutation. BRAF mutation is considered to be a crucial step in the initiation of melanocyte transformation. However, using immunomagnetic separation or laser-capture microdissection, we examined BRAF mutations in sets of approximately 50 single cells isolated from acquired melanocytic nevi from 13 patients and found a substantial number of nevus cells that contained wild-type BRAF mixed with nevus cells that contained BRAF V600E . Furthermore, we simultaneously amplified BRAF exon 15 and a neighboring single nucleotide polymorphism (SNP), rs7801086, from nevus cell samples obtained from four patients who were heterozygous for this SNP. Subcloning and sequencing of the polymerase chain reaction products showed that both SNP alleles harbored the BRAF V600E mutation, indicating that the same BRAF V600E mutation originated from different cells. The polyclonality of BRAF mutations in acquired melanocytic nevi suggests that mutation of BRAF may not be an initial event in melanocyte transformation.
Geographical variation of disease manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials and Research (EUSTAR) group database
Authors: U A Walker, A Tyndall, L Czirjak, C P Denton, D Farge-Bancel, O Kowal-Bielecka, U Muller-Ladner, M Matucci-Cerinic
Journal: Annals of the Rheumatic Diseases (2008)

Systemic sclerosis (SSc) is a vasculopathy with increased tissue deposition of collagen. The aetiology is unknown. Genetic and environmental susceptibility factors have been implicated. It is unknown whether disease presentation varies within Europe.The baseline data of all SSc patients entered in the EULAR Scleroderma Trials and Research (EUSTAR) database up to April 2007 were analysed for geographical differences with regard to organ involvement, and geographical clusters with regard to clinical subsets (diffuse vs limited SSc) and autoantibodies (anticentromere vs anti-Scl70).3661 patients from 79 centres in 62 cities and 23 countries were analysed. There was no clear trend between geographical coordinates and SSc subsets, although there appeared to be an increased prevalence of Scl70 in the more eastern centres. There was no association between geographical longitude or latitude and the age at the onset of Raynaud's phenomenon or the onset of non-Raynaud's symptoms. There was also a trend for the more eastern centres to care for patients with a higher prevalence of more severe organ manifestations (pulmonary arterial hypertension, cardiac involvement). Between different centres within one city there was a large variability in the frequency of organ complications.This analysis suggests that eastern centres care for more severe SSc manifestations in Europe. Large differences in patient referral account for a large local variability of SSc presentations and preclude the identification of genetic or environmental factors.
Radial versus femoral approach for percutaneous coronary diagnostic and interventional procedures
Authors: Pierfrancesco Agostoni, Giuseppe G.L. Biondi-Zoccai, M.Luisa De Benedictis, Stefano Rigattieri, Marco Turri, Maurizio Anselmi, Corrado Vassanelli, Piero Zardini, Yves Louvard, Martial Hamon
Journal: Journal of the American College of Cardiology (2004)
Improved Survival Following Injection Sclerotherapy for Esophageal Varices: Final Analysis of A Controlled Trial
Authors: David Westaby, Brian R.D. Macdougall, Roger Williams
Journal: Hepatology (1985)

Long–term follow–up (median: 37 months; range: 19 to 68) of the 116 patients (56 sclerotherapy, 60 control group) entered into a controlled trial of endoscopic variceal sclerotherapy has shown a total of 18 deaths in the sclerotherapy group, including five from variceal bleeding compared with 32 deaths in the control group (p &lt; 0.01), of which 25 were from variceal hemorrhage (p &lt; 0.001). Survival as assessed by cumulative life analysis was significantly better in those treated by sclerotherapy (p &lt; 0.001). Both the cumulative proportion of patients rebleeding and the total number of episodes of variceal hemorrhage were also significantly less in the sclerotherapy group (p &lt; 0.01). Recurrence of varices was observed in 27 of 45 patients in whom variceal obliteration was initially observed at a median of 11 months (range: 2 to 27) later, although in only 12 of these did bleeding recur and was the cause of death in one.
Chinese Herbal Medicine
Authors: H. A. Reid
Journal: BMJ (1975)

Background/Aim: Previous reports have associated the KMT2A-ELL fusion gene, generated by t(11;19)(q23;p13.1), with acute myeloid leukemia (AML). We herein report a KMT2A-ELL and a novel ZNF56-KMT2A fusion genes in a pediatric T-lineage acute lymphoblastic leukemia (T-ALL). Materials and Methods: Genetic investigations were performed on bone marrow of a 13-year-old boy diagnosed with T-ALL. Results: A KMT2A-ELL and a novel ZNF56-KMT2A fusion genes were generated on der(11)t(11;19)(q23;p13.1) and der(19)t(11;19)(q23;p13.1), respectively. Exon 20 of KMT2A fused to exon 2 of ELL in KMT2A-ELL chimeric transcript whereas exon 1 of ZNF56 fused to exon 21 of KMT2A in ZNF56-KMT2A transcript. A literature search revealed four more T-ALL patients carrying a KMT2A-ELL fusion. All of them were males aged 11, 11, 17, and 20 years. Conclusion: KMT2A-ELL fusion is a rare recurrent genetic event in T-ALL with uncertain prognostic implications. The frequency and impact of ZNF56-KMT2A in T-ALL are unknown.
The cycle of the nitric oxide metabolism in patients with COPD and chronic cerebrovascular diseases (CCVD)
Authors: Svetlana Soodaeva, Timur Li, Igor Klimanov, Larisa Postnikova, Nailja Kubysheva, Olga Mironova, Anatoliy Fedin
Journal: European Respiratory Journal (2013)

The aim  of the study was to investigate the cycle of the nitric oxide (NO) in COPD only, and in combination COPD and CCVD.   Materials and methods . The study included 62 patients aged 52-70 years. All patients were divided in two groups: group1 contains 30 patients with COPD and CCVD; group 2 contains 32 patients with COPD only. The control group consisted of 33 healthy non-smoking volunteers. The investigation of the nitric oxide metabolism was performed by the estimation of the concentration of the stable NO metabolites - nitrate anions (NO3-) and nitrite anions (NO2-), their total concentration (TNN) and 3-nitrothyrozine (3-NT) level in blood plasma.   Results.  The NO3- levels were significantly higher in group1 and 2 (23.5 + / -8.8 μM, p    Conclusion.  The development of the nitrosative stress in COPD and in combination COPD with CCVD is related with the cycle of NO.
Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis
Authors: Birgit Schittek, Tobias Sinnberg
Journal: Molecular Cancer (2014)

Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key regulatory molecules involved in cell cycle, transcription and translation, the structure of the cytoskeleton, cell-cell adhesion and receptor-coupled signal transduction. They regulate key signaling pathways known to be critically involved in tumor progression. Recent results point to an altered expression or activity of different CK1 isoforms in tumor cells. This review summarizes the expression and biological function of CK1 family members in normal and malignant cells and the evidence obtained so far about their role in tumorigenesis.
MRI-Based Liver Iron Content Predicts for Nonrelapse Mortality in MDS and AML Patients Undergoing Allogeneic Stem Cell Transplantation
Authors: Martin Wermke, Anne Schmidt, Jan Moritz Middeke, Katja Sockel, Malte von Bonin, Claudia Schönefeldt, Sabine Mair, Verena Plodeck, Michael Laniado, Günter Weiss, Johannes Schetelig, Gerhard Ehninger, Igor Theurl, Martin Bornhäuser, Uwe Platzbecker
Journal: Clinical Cancer Research (2012)

Abstract Purpose: Retrospective, surrogate marker–based studies have found inconsistent associations between systemic iron overload (SIO) and adverse outcome in patients undergoing allogeneic stem cell transplantation (allo-SCT). As a consequence, the impact of SIO in this context remains under debate. The aim of this study was to test whether the objective pretransplant quantification of liver-iron content (LIC) by magnetic resonance imaging (MRI) could circumvent these limitations and conclusively define the prognostic relevance of SIO. Experimental Design: The correlation between pretransplant LIC and surrogate parameters as well as the impact of SIO on posttransplant outcome was assessed within an observational study of patients (n = 88) with either myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) undergoing allo-SCT. Results: Ferritin levels of 1,000 ng/mL or more provided only poor specificity (31.8%) for predicting elevated LIC (≥125 μmol/g) and even higher thresholds (≥2,500 ng/mL) lacked an association with nonrelapse mortality (NRM). In contrast, LIC 125 μmol/g or more was a significant risk factor for NRM in uni- and multivariate analysis (HR = 2.98; P = 0.016). Multivariate Cox-regression further showed that LIC 125 μmol/g or more was associated with a decreased overall survival (HR = 2.24, P = 0.038), whereas ferritin or transfusion burden were not. Conclusions: SIO reflected by LIC is an independent negative prognostic factor for posttransplant outcome in patients with AML and MDS undergoing allo-SCT. Therefore, MRI-based LIC, and not interference-prone serum markers such as ferritin, should be preferred for pretransplant risk stratification and patient selection in future clinical trials. Clin Cancer Res; 18(23); 6460–8. ©2012 AACR.
Dietary Feeding of Silibinin Inhibits Prostate Tumor Growth and Progression in Transgenic Adenocarcinoma of the Mouse Prostate Model
Authors: Komal Raina, Marie-José Blouin, Rana P. Singh, Noreen Majeed, Gagan Deep, Leyon Varghese, L. Michael Glodé, Norman M. Greenberg, David Hwang, Pinchas Cohen, Michael N. Pollak, Rajesh Agarwal
Journal: Cancer Research (2007)

Abstract Herein, for the first time, we evaluated the chemopreventive efficacy of dietary silibinin against prostate cancer (PCa) growth and progression in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice from two different genetic backgrounds [C57BL/6 (TRAMP) × FVB; C57BL/6 (TRAMP) × C57BL/6]. At 4 weeks of age, mice were fed control or 0.1% to 1% silibinin–supplemented diets until 23 to 24 weeks of age. Silibinin-fed groups had a lower tumor grade and higher incidence of prostatic intraepithelial neoplasia (PIN) at the expense of a strong decrease in adenocarcinoma incidence. Prostate tissue showed a 47% (P &amp;lt; 0.001) decrease in proliferating cell nuclear antigen (PCNA)–positive cells and an ∼7-fold (P &amp;lt; 0.001) increase in apoptotic cells at the highest silibinin dose. As potential mechanisms of silibinin efficacy, an ∼50% (P &amp;lt; 0.05) decrease in insulin-like growth factor (IGF) receptor type Iβ and an ∼13-fold (P &amp;lt; 0.001) increase in IGF-binding protein 3 (IGFBP-3) protein levels were also observed. These changes were specific to tumors as they were not reflected in circulating IGF-IGFBP-3 system. Additionally, silibinin decreased protein expression of cyclin-dependent kinases (Cdk) by more than 90% (P &amp;lt; 0.001) with a concomitant increase in Cdk inhibitors, Cip1/p21 and Kip1/p27 (P &amp;lt; 0.05, for both). A dose-dependent decrease was also observed in cyclin B1, cyclin E, and cyclin A protein levels by silibinin. Together, these findings suggest that oral silibinin blocks PCa growth and progression at PIN stage in TRAMP mice via modulation of tumor IGF-IGFBP-3 axis and cell cycle regulation, and therefore it has practical and translational potential in suppressing growth and neoplastic conversion of PIN to PCa in humans. [Cancer Res 2007;67(22):11083–91]
Colistin as a first choice antibiotic for the initial empiric antimicrobial therapy of ventilator-associated pneumonia
Authors: K. Ioannides, P. Myrianthefs, G. Baltopoulos
Journal: European Respiratory Journal (2007)

Colistin as a first choice antibiotic for the initial empiric antimicrobial therapy of ventilator-associated pneumoniaTo the Editors:We read with great interest the article recently published in the European Respiratory Journal (ERJ) by RIOS et al.[1] regarding ventilator-associated pneumonia (VAP) due to colistin susceptible-only microorganisms.The authors concluded that colistin could be a suitable antibiotic for the initial empiric antimicrobial therapy in their intensive care unit (ICU) since they identified 30 carbapenem-sensitive (Carb-S) and 31 colistin-sensitive (Col-S) isolates.
Prophylaxis of infectious complications with colony-stimulating factors in adult cancer patients undergoing chemotherapy—evidence-based guidelines from the Infectious Diseases Working Party AGIHO of the German Society for Haematology and Medical Oncology (DGHO)
Authors: J.J. Vehreschild, A. Böhme, O.A. Cornely, C. Kahl, M. Karthaus, K.-A. Kreuzer, G. Maschmeyer, S. Mousset, V. Ossendorf, O. Penack, M.J.G.T. Vehreschild, J. Bohlius
Journal: Annals of Oncology (2014)