tbuckley/cabot-search huggingface dataset:
Effect of Weight Loss on the Severity of Psoriasis
Authors: Peter Jensen, Claus Zachariae, Robin Christensen, Nina R. W. Geiker, Bente K. Schaadt, Steen Stender, Peter R. Hansen, Arne Astrup, Lone Skov
Journal: JAMA Dermatology (2013)

<h3>Importance</h3> Psoriasis is associated with adiposity and weight gain increases the severity of psoriasis and the risk of incident psoriasis. Therefore, we aimed to measure the effect of weight reduction on the severity of psoriasis in obese patients with psoriasis. <h3>Objective</h3> To assess the effect of weight reduction on the severity of psoriasis in overweight patients. <h3>Design</h3> Sixty obese patients with psoriasis from our dermatology outpatient clinic were enrolled in a prospective randomized clinical trial in which they were allocated to a control group or an intervention group. <h3>Setting</h3> University hospital outpatient dermatology clinic. <h3>Participants</h3> We included 60 of 69 eligible overweight patients with psoriasis (body mass index [calculated as weight in kilograms divided by height in meters squared], 27-40; aged 25-71 years). <h3>Interventions</h3> The intervention group received a low-energy diet (LED) (800-1000 kcal/d) for 8 weeks to induce weight loss, followed by 8 weeks of reintroduction of normal food intake, reaching 1200 kcal/d. The control group was instructed to continue eating ordinary healthy foods. <h3>Main Outcomes and Measures</h3> Psoriasis Area and Severity Index (PASI) after 16 weeks, with Dermatology Life Quality Index (DLQI) as a secondary end point. <h3>Results</h3> The median PASI for all patients was 5.4 (interquartile range, 3.8-7.6) at baseline. At week 16, the mean body weight loss was 15.4 kg (95% CI, 12.3-18.5 kg;<i>P</i> &lt; .001) greater in the intervention group than in the control group. The corresponding mean differences in PASI and DLQI, also in favor of the LED group, were −2.0 (95% CI, 4.1 to −0.1;<i>P</i> = .06) and −2.0 (95% CI, −3.6 to −0.3;<i>P</i> = .02), respectively. <h3>Conclusions and Relevance</h3> Treatment with an LED showed a trend in favor of clinically important PASI improvement and a significant reduction in DLQI in overweight patients with psoriasis. <h3>Trial Registration</h3> clinicaltrials.gov Identifier:NCT01137188
Educating children and young people with special needs.
Authors: B. Taylor
Journal: BMJ (1989)

drinking alcohol after 6 pm, through to providing nasal continuous positive airway pressure'5 or, in selected cases, pharyngeal surgery. 16inally, given that the prevalence of symptomatic sleep apnoea is not known, we need more epidemiological research to clarify its contribution to deiths on our roads-with tests of vigilance and performance together with confidential inquiries into the causes of accidents, which should include questions to detect sleepiness and obstructive sleep apnoea.
An analysis of the reliability of detection and diagnostic value of various pathological features in Crohn's disease and ulcerative colitis
Authors: M. G. Cook, M. F. Dixon
Journal: Gut (1973)

Two pathologists have independently applied 95 separate pathological criteria to 50 cases of inflammatory large bowel disease firmly diagnosed clinically as 25 cases of Crohn's disease and 25 cases of ulcerative colitis. The observer agreement in the recording of each feature has been calculated and correlations have been made between the pathological features and the final agreed diagnosis in order to obtain an estimate of the value of each feature in differential diagnosis. The features which have been found to be most accurately observed and useful in the diagnosis of Crohn's disease include confluent linear ulcers, deep fissures, an aggregated inflammatory pattern, and sarcoid-like granulomata. The features which have been shown to be most accurate and valuable in the diagnosis of ulcerative colitis include a ;healed granular' mucosa, a continuous inflammatory pattern, an irregular gland pattern, and the absence of fissures. The authors consider that the use of such accurate and valuable pathological criteria in the examination of inflammatory bowel disease would facilitate retrospective correlation with the clinical findings and help to clarify those intermediate cases which are at present a source of diagnostic difficulty.
Effect of a closed loop ventilation strategy on the duration of ICU stay: A randomized controlled trial (interim analysis results)
Authors: Cenk Kirakli, Ozlem Ediboglu, Dursun Tatar, Emel Tellioglu, Ahmet Budak, Ilknur Naz
Journal: European Respiratory Journal (2012)

Background and aim: There are some studies suggesting that adaptive support ventilation (ASV), a closed loop ventilation mode, shortens the weaning duration in some patient groups. We aimed to investigate the effect of ASV on total duration of mechanical ventilation (MV), weaning and intensive care unit (ICU) stay when compared to pressure controlled ventilation (PCV), a conventional mode.  Materials and Methods: Patients who were mechanically ventilated longer than 24 hours were randomized into ASV and PCV. Demographic data and total duration of MV, weaning and ICU stay, total number of manuplations, need for sedation and complications (self-extubation, ventilator associated pneumonia) were compared.  Results: Data are expressed as median (IQR). 96 patients (73 COPD) were enrolled between December 2011 and February 2012. Duration of weaning was 2 hours (2–7) in ASV and 4 hours (2–26) in PCV (p=0.013). Number of manuplations were 2 (1–3) in ASV and 3 (1–6) in PCV (p  Conclusion: ASV seems to decrease the staff9s workload, duration of weaning and ICU stay when performed from intubation until extubation. The present study is continuing until the targeted sample size is reached in order to detect the effects of this mode on secondary outcomes such as total duration of mechanical ventilation and need of sedation.
THE PATHOGENESIS OF<i>HELICOBACTER PYLORI</i>–INDUCED GASTRO-DUODENAL DISEASES
Authors: John C. Atherton
Journal: Annual Review of Pathology Mechanisms of Disease (2006)

Helicobacter pylori is the main cause of peptic ulceration, distal gastric adenocarcinoma, and gastric lymphoma. Only 15% of those colonized develop disease, and pathogenesis depends upon strain virulence, host genetic susceptibility, and environmental cofactors. Virulence factors include the cag pathogenicity island, which induces proinflammatory, pro-proliferative epithelial cell signaling; the cytotoxin VacA, which causes epithelial damage; and an adhesin, BabA. Host genetic polymorphisms that lead to high-level pro-inflammatory cytokine release in response to infection increase cancer risk. Pathogenesis is dependent upon inflammation, a Th-1 acquired immune response and hormonal changes including hypergastrinaemia. Antral-predominant inflammation leads to increased acid production from the uninflamed corpus and predisposes to duodenal ulceration; corpus-predominant gastritis leads to hypochlorhydria and predisposes to gastric ulceration and adenocarcinoma. Falling prevalence of H. pylori in developed countries has led to a falling incidence of associated diseases. However, whether there are disadvantages of an H. pylori-free stomach, for example increased risk of esosphageal adenocarcinoma, remains unclear.
Increased maximal pulmonary response to methacholine and airway smooth muscle in immature compared with mature rabbits.
Authors: R S Tepper, T Du, A Styhler, M Ludwig, J G Martin
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We compared the effect of maturation upon the maximal pulmonary response to inhaled methacholine in rabbits and also assessed whether there was an age-related difference in the quantity of airway smooth muscle. In sedated, paralyzed, and mechanically ventilated rabbits, pulmonary resistance was measured following increasing doses of aerosolized methacholine (0.5 to 256 mg/ml). The six mature rabbits (6 mo) demonstrated a plateau in their dose-response curves whereas only three of six immature animals (1 mo) had a plateau. The immature compared with the mature animals had a greater maximal increase in pulmonary resistance (950% versus 380%). The lungs were examined by light microscopy to determine morphometrically the area of smooth muscle (ASM) in the airway walls. ASM was normalized for airway size by dividing by the ideal airway area. The normalized ASM was different for the two age groups and the immature animals' airways had more smooth muscle. The relationship between airway size and ASM was similar for the two age groups with smaller airways having proportionately more smooth muscle. The differences with age in ASM area were primarily due to the immature animals having a greater number of airways of small size. There was not a significant relationship between the maximal percent increase in pulmonary resistance and the normalized ASM. We conclude that inhaled methacholine produces a greater maximal increase in the pulmonary resistance of immature than mature rabbits and that this difference is unlikely to be caused by a proportionately greater quantity of ASM in the immature than the mature rabbit airways.
Unusual Leukemia Presentations
Authors: Simon Mantha, Michael I. Jacobs, David G. Savage
Journal: Journal of Clinical Oncology (2005)

6][7] Other organs may be involved, including the gastrointestinal tract, but involvement of the large bowel has only been reported in a few case reports. [8][][10][11] GS usually occurs concomitantly with or after the onset of AML. 2,12However, on rare occasions, it evolves before the onset of AML, and a misdiagnosis of lymphoma is frequently made. 13 Diagnostic distinction from a high-grade non-Hodgkin's lymphoma, especially large cell lymphoma can be difficult in patients without bone marrow involvement. 14 The diagnosis is aided by histochemical stains, especially napthol-ASD-chloroacetate esterase (NACE; Leder stain), or by immunoperoxidase staining with monoclonal antibodies for myeloperoxidase, lysozyme, or CD34 antigen. 15 Flow cytometry or cytogenetic analysis of the specimen can be helpful.Immunophenotyping is more important in cases in which NACE staining is negative because of immaturity of the tumor cells.If there is no discernible hematologic abnormality at the time of diagnosis, and if treated with either surgery or local radiotherapy with no further systemic chemotherapy, up to 80% to 90% of patients develop AML at a mean of 11 months after the diagnosis of GS. 2 But if patients are treated with aggressive chemotherapy with AML regimens, the projected 3-year survival is reported to be 30%.
RABBIT SEPTICEMIA BACILLUS, TYPES D AND G, IN NORMAL RABBITS
Authors: Paul H. De Kruif
Journal: The Journal of Experimental Medicine (1922)

Microbe G, rabbit septicemia bacillus, hitherto found only as a mutant in cultures of the rabbit septicemia bacillus, Type D, has been demonstrated to exist on the nasal mucous membranes of normal rabbits. This organism corresponds in lack of virulence, character of growth, acid agglutination optimum, and immune agglutination reaction, to the mutant G form described in previous papers. Microbe D has been found to be present on the nasal mucous membranes of normal rabbits. These animals have survived for months with no evidence of infection other than the presence of the organism. These Type D organisms, despite their failure to cause fatal damage in their own host, are shown to possess the typical high virulence characteristic of this type, when injected intrapleurally into young rabbits. Rabbits which are carriers of Type D or G possess a definite amount of immune agglutinins, as evidenced by test of their serum against Microbe G at pH 7.1. Rabbits free from infection with these organisms invariably have yielded a serum which fails to agglutinate Type G completely in 1:10 or higher dilutions.
Prevention of duodenal ulcers in the rat using a combination of ranitidine and sucralphate in subtherapeutic doses.
Authors: S Bank, H Zimmerman, C Smolow, V Kranz
Journal: Gut (1985)

This study investigated whether ulcer prevention would be greater with the combined use of an acid-inhibiting agent, ranitidine, given together with a mucosal-protective agent, sucralphate. Duodenal ulcers were induced in rats with the secretagogues pentagastrin and bethanechol. Subtherapeutic doses of ranitidine (5 mg/kg/6 hours) and sucralphate (50 mg/6 hour) yielded an ulcer index of 4.0 and 4.1 respectively, not significantly different from the control (untreated) ulcer index of 4.3. Therapeutic doses of ranitidine (20 mg/kg) and sucralphate (200 mg/animal) gave an ulcer index of 0.4 and 0.5 respectively. Subtherapeutic doses of ranitidine and sucralphate given in combination yielded an ulcer index of 0.7. Thus, subtherapeutic doses of ranitidine and sucralphate given in combination had a synergistic effect equal to therapeutic doses of each of these drugs given alone. The therapeutic implications of combined acid inhibiting drugs with mucosal protective drugs is discussed.
Relapsing Pulmonary Langerhans Cell Histiocytosis after Lung Transplantation
Authors: BÉNÉDICTE ETIENNE, MICHÈLE BERTOCCHI, JEAN-PAUL GAMONDES, FABRICE THÉVENET, CHRISTOPHE BOUDARD, THÉRÈSE WIESENDANGER, ROBERT LOIRE, JEAN BRUNE, JEAN-FRANÇOIS MORNEX
Journal: American Journal of Respiratory and Critical Care Medicine (1998)
Systemic Corticosteroids Reduce Peripheral Blood Regulatory T Cells in Chronic Rhinosinusitis (CRS): A Controlled Trial
Authors: S. Watanabe, S. Sharma, M.E. Bashir, M. DeTineo, F.M. Baroody, R.M. Naclerio, J.M. Pinto
Journal: Journal of Allergy and Clinical Immunology (2011)
Genetic syndrome with ichthyosis: congenital ichthyosis, follicular atrophoderma, hypotrichosis, and woolly hair; second report
Authors: U. Tursen, T.I. Kaya, G. Ikizoglu, M. Aktekin, N. Aras
Journal: British Journal of Dermatology (2002)

Journal Article Genetic syndrome with ichthyosis: congenital ichthyosis, follicular atrophoderma, hypotrichosis, and woolly hair; second report Get access U. Tursen, U. Tursen Departments of Dermatology, *Anatomy, and †Medical Biology and Genetics, Mersin University, Faculty of Medicine, Zeytinlibahce, 33070, Mersin, Turkey E‐mail: utursen@mersin.edu.tr Dr Umit Tursen, Mersin Üniversitesi Tıp Fakültesi Hastanesi, Dermatoloji AnabilimDalı, 33070 Zeytinlibahce, Mersin, Turkey Search for other works by this author on: Oxford Academic Google Scholar T.I. Kaya, T.I. Kaya Departments of Dermatology, *Anatomy, and †Medical Biology and Genetics, Mersin University, Faculty of Medicine, Zeytinlibahce, 33070, Mersin, Turkey E‐mail: utursen@mersin.edu.tr Search for other works by this author on: Oxford Academic Google Scholar G. Ikizoglu, G. Ikizoglu Departments of Dermatology, *Anatomy, and †Medical Biology and Genetics, Mersin University, Faculty of Medicine, Zeytinlibahce, 33070, Mersin, Turkey E‐mail: utursen@mersin.edu.tr Search for other works by this author on: Oxford Academic Google Scholar M. Aktekin, M. Aktekin Departments of Dermatology, *Anatomy, and †Medical Biology and Genetics, Mersin University, Faculty of Medicine, Zeytinlibahce, 33070, Mersin, Turkey E‐mail: utursen@mersin.edu.tr Search for other works by this author on: Oxford Academic Google Scholar N. Aras N. Aras Departments of Dermatology, *Anatomy, and †Medical Biology and Genetics, Mersin University, Faculty of Medicine, Zeytinlibahce, 33070, Mersin, Turkey E‐mail: utursen@mersin.edu.tr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 3, 1 September 2002, Pages 604–606, https://doi.org/10.1046/j.1365-2133.2002.48461.x Published: 01 September 2002
Safety and Immunologic Response of a Viral Vaccine to Prostate-Specific Antigen in Combination with Radiation Therapy when Metronomic-Dose Interleukin 2 Is Used as an Adjuvant
Authors: Robert J. Lechleider, Philip M. Arlen, Kwong-Yok Tsang, Seth M. Steinberg, Junko Yokokawa, Vittore Cereda, Kevin Camphausen, Jeffrey Schlom, William L. Dahut, James L. Gulley
Journal: Clinical Cancer Research (2008)

Abstract Purpose: We have previously reported on the safety and immunologic response of a poxvirus-based vaccine encoding prostate-specific antigen (PSA) used in combination with radiation therapy in patients with localized prostate cancer. We hypothesized that a “metronomic” dose of interleukin 2 (IL-2) as a biological adjuvant would cause less toxicity while maintaining immunologic response. Experimental Design: Eighteen patients with localized prostate cancer were treated in a single-arm trial using previously established doses of vaccine and radiation therapy. The vaccine used was a recombinant vaccinia virus engineered to encode PSA admixed with a recombinant vaccinia encoding the costimulatory molecule B7.1, followed by booster vaccinations with a recombinant fowlpox vector expressing PSA. Patients received a total of eight planned vaccination cycles, once every 4 weeks, with granulocyte-macrophage colony-stimulating factor given on days 1 to 4 and interleukin 2 (IL-2) at a dose of 0.6 MIU/M2 given from days 8 to 21 after each vaccination. Definitive external beam radiation therapy was initiated after the third vaccination cycle. Patients were evaluated for safety and immunologic response. Toxicity and immunologic activity were compared with the previously reported regimen containing a higher dose of IL-2. Results: Seventeen of 18 patients received all eight cycles of vaccine with IL-2. Five of eight HLA-A2+ patients evaluated had an increase in PSA-specific T cells of ≥3-fold. Toxicities were generally mild, with only seven vaccination cycles of 140 given resulting in grade 3 toxicities possibly attributable to IL-2. Conclusions: Metronomic-dose IL-2 in combination with vaccine and radiation therapy is safe, can induce prostate-specific immune responses, and has immunologic activity similar to low-dose IL-2, with markedly reduced toxicities.
Giant warts in a kidney transplant patient: regression with sirolimus
Authors: M. Kostaki, J.P. Venetz, G. Nseir, P. Meylan, R. Sahli, M. Pascual, E. Laffitte
Journal: British Journal of Dermatology (2010)

Journal Article Giant warts in a kidney transplant patient: regression with sirolimus Get access M. Kostaki, M. Kostaki Department of Dermatology, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Geneva, Switzerland *Transplant Center and †Microbiology, CHUV Bâtiment Hospitalier, Rue du Bugnon 46, 1011 Lausanne, Switzerland E‐mail: maria.kostaki@hcuge.ch Search for other works by this author on: Oxford Academic Google Scholar J.P. Venetz, J.P. Venetz Department of Dermatology, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Geneva, Switzerland *Transplant Center and †Microbiology, CHUV Bâtiment Hospitalier, Rue du Bugnon 46, 1011 Lausanne, Switzerland E‐mail: maria.kostaki@hcuge.ch Search for other works by this author on: Oxford Academic Google Scholar G. Nseir, G. Nseir Department of Dermatology, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Geneva, Switzerland *Transplant Center and †Microbiology, CHUV Bâtiment Hospitalier, Rue du Bugnon 46, 1011 Lausanne, Switzerland E‐mail: maria.kostaki@hcuge.ch Search for other works by this author on: Oxford Academic Google Scholar P. Meylan, P. Meylan Department of Dermatology, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Geneva, Switzerland *Transplant Center and †Microbiology, CHUV Bâtiment Hospitalier, Rue du Bugnon 46, 1011 Lausanne, Switzerland E‐mail: maria.kostaki@hcuge.ch Search for other works by this author on: Oxford Academic Google Scholar R. Sahli, R. Sahli Department of Dermatology, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Geneva, Switzerland *Transplant Center and †Microbiology, CHUV Bâtiment Hospitalier, Rue du Bugnon 46, 1011 Lausanne, Switzerland E‐mail: maria.kostaki@hcuge.ch Search for other works by this author on: Oxford Academic Google Scholar M. Pascual, M. Pascual Department of Dermatology, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Geneva, Switzerland *Transplant Center and †Microbiology, CHUV Bâtiment Hospitalier, Rue du Bugnon 46, 1011 Lausanne, Switzerland E‐mail: maria.kostaki@hcuge.ch Search for other works by this author on: Oxford Academic Google Scholar E. Laffitte E. Laffitte Department of Dermatology, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Geneva, Switzerland *Transplant Center and †Microbiology, CHUV Bâtiment Hospitalier, Rue du Bugnon 46, 1011 Lausanne, Switzerland E‐mail: maria.kostaki@hcuge.ch Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 5, 1 May 2010, Pages 1148–1150, https://doi.org/10.1111/j.1365-2133.2010.09687.x Published: 01 May 2010
Proliferation in vivo of T lymphocytes reactive to histocompatibility alloantigens: a correction.
Authors: P C Nowell, J B Finan, D B Wilson
Journal: The Journal of Experimental Medicine (1975)

Rat lymphocytes in mixed cultures can reutilize tritiated thymidine from labeled granulocytes. Shortly after thymidine injections in vivo, major effects on the frequency of labeled lymphocyte mitoses in peripheral blood cultures are introduced by 10-20% polymorph contamination, even though transfer of label via supernates is not demonstrable. Cold thymidine in the cultures prevents reutilization, and has permitted reevaluation of several previous conclusions concerning the life history of lymphocytes reactive to major histocompatibility alloantigens (HARC). Rather than being predominantly recently divided cells, HARC do not appear to have an age distribution, in blood or lymph, significantly different from the general recirculating lymphocyte population. However, the ability of immunization across strong allogeneic differences to increase markedly the proportion of young HARC among the specifically responsive population has been confirmed.
Four and a half LIM protein 1: a novel chaperone for atrium-specific Kv1.5 channels with a potential role in atrial arrhythmogenesis
Authors: D. Dobrev, E. Wettwer
Journal: Cardiovascular Research (2008)

Chronic atrial diseases are associated with electrical, mechanical, and structural changes (remodelling) that result from activation of diverse signal transduction pathways. In atrial fibrillation (AF), the high atrial rate abbreviates the atrial action potential duration primarily by reduced I Ca,L and increased inward-rectifier K+ currents like the background current ( I K1) and a constitutively active form of the acetylcholine-dependent K+ current ( I K,ACh).1,2 There is also evidence for AF-associated reduction in the ultra-rapid delayed-rectifier I Kur, although the reported findings have been inconsistent and the underlying molecular mechanisms are less clear.1 Response rate to antiarrhythmic drugs is low with respect to termination of AF or maintenance of sinus rhythm, and many of the drugs lead to adverse effects including ventricular arrhythmias. Given these limitations, an alternative approach is to design drugs that target atrium-selective ion channels like I Kur, which plays a role in AF pathophysiology but not in ventricular function. However, our knowledge of the cellular processes underlying normal regulation of I Kur are still incomplete.

In order to contribute to atrial function in a specific way, the different ion channels have to be in the right place at the right … 

*Corresponding author. Tel: +49 351 458 6279; fax: +49 351 458 6315. E-mail address : dobrev{at}rcs.urz.tu-dresden.de