Metabolically Healthy Overweight and Obesity
Authors: Nathalie Esser, André J. Scheen, Nicolas Paquot
Journal: Annals of Internal Medicine (2014)

Letters1 April 2014Metabolically Healthy Overweight and ObesityNathalie Esser, MD, André J. Scheen, MD, PhD, and Nicolas Paquot, MD, PhDNathalie Esser, MDFrom University Hospital of Liege, Liege, Belgium.Search for more papers by this author, André J. Scheen, MD, PhDFrom University Hospital of Liege, Liege, Belgium.Search for more papers by this author, and Nicolas Paquot, MD, PhDFrom University Hospital of Liege, Liege, Belgium.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5007-3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITORKramer and colleagues (1) report that obese persons are at long-term risk for cardiovascular events and total mortality regardless of their metabolic status. The discrimination of participants according to a metabolic score is an oversimplified dichotomous classification that does not reflect the huge heterogeneity of obesity. Metabolically healthy persons, as classically defined, may still have metabolic disorders.In Kramer and colleagues' meta-analysis, metabolically healthy obese persons had an intermediate risk for total mortality and cardiovascular events, higher than that for metabolically healthy lean and overweight persons but lower than that for metabolically unhealthy overweight and obese persons. ...References1. Kramer CK, Zinman B, Retnakaran R. Are metabolically healthy overweight and obesity benign conditions?: A systematic review and meta-analysis. Ann Intern Med. 2013;159:758-69. [PMID: 24297192] LinkGoogle Scholar2. Appleton SL, Seaborn CJ, Visvanathan R, Hill CL, Gill TK, Taylor AW, et al; North West Adelaide Health Study Team. Diabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype: a cohort study. Diabetes Care. 2013;36:2388-94. [PMID: 23491523] CrossrefMedlineGoogle Scholar3. Esser N, L'homme L, De Roover A, Kohnen L, Scheen AJ, Moutschen M, et al. Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue. Diabetologia. 2013;56:2487-97. [PMID: 24013717] CrossrefMedlineGoogle Scholar4. Wildman RP, Kaplan R, Manson JE, Rajkovic A, Connelly SA, Mackey RH, et al. Body size phenotypes and inflammation in the Women's Health Initiative Observational Study. Obesity (Silver Spring). 2011;19:1482-91. [PMID: 21233809] CrossrefMedlineGoogle Scholar5. Hinnouho GM, Czernichow S, Dugravot A, Batty GD, Kivimaki M, Singh-Manoux A. Metabolically healthy obesity and risk of mortality: does the definition of metabolic health matter? Diabetes Care. 2013;36:2294-300. [PMID: 23637352] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University Hospital of Liege, Liege, Belgium.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAre Metabolically Healthy Overweight and Obesity Benign Conditions? Caroline K. Kramer , Bernard Zinman , and Ravi Retnakaran Metabolically Healthy Overweight and Obesity Jean-Philippe Chaput and Arya M. Sharma Metabolically Healthy Overweight and Obesity Dorit Samocha-Bonet , Antony D. Karelis , and Rémi Rabasa-Lhoret Metabolically Healthy Overweight and Obesity Gerson T. Lesser Metabolically Healthy Overweight and Obesity Juhee Cho , Yoosoo Chang , and Seungho Ryu Metabolically Healthy Overweight and Obesity Katherine M. Flegal Metabolically Healthy Overweight and Obesity Caroline K. Kramer , Bernard Zinman , and Ravi Retnakaran Metabolically Healthy Overweight and Obesity Dorit Samocha-Bonet , Antony D. Karelis , and Rémi Rabasa-Lhoret Metabolically Healthy Overweight and Obesity Katherine M. Flegal Metabolically Healthy Overweight and Obesity Caroline K. Kramer , Bernard Zinman , and Ravi Retnakaran Metabolically Healthy Overweight and Obesity Gerson T. Lesser Metabolically Healthy Overweight and Obesity Juhee Cho , Yoosoo Chang , and Seungho Ryu Metabolically Healthy Overweight and Obesity Jean-Philippe Chaput and Arya M. Sharma Metrics Cited ByObésité métaboliquement normale 1 April 2014Volume 160, Issue 7Page: 514KeywordsAdipose tissueLymphocytesMedical risk factorsMetabolic disordersMetabolic syndromeObesityOverweightRisk managementType 2 diabetes ePublished: 1 April 2014 Issue Published: 1 April 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...