tbuckley/cabot-search huggingface dataset:
Care Quality Commission is still not up to the job, MPs’ report finds
Authors: Zosia Kmietowicz
Journal: BMJ (2015)

Three years after MPs delivered a scathing attack on England’s NHS and care regulator, calling it unfit for purpose,1 a new report has said that it is still not up to the job.2

While “substantial progress” has been made at the Care Quality Commission since 2012, it is currently behind schedule on inspections, is beset with staff shortages, and is too slow in responding to tip-offs of poor service and in delivering its reports, MPs on the Public Accounts Committee said.2

Meg Hillier, chair of the committee, said, “Six years after being set up the Care Quality Commission is still not fully effective. There’s too often a long gap …
Graduate Medical Education, 2014-2015
Authors: Sarah E. Brotherton, Sylvia I. Etzel
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intranasal drug delivery: An efficient and non-invasive route for systemic administration
Authors: Stanislas Grassin-Delyle, Amparo Buenestado, Emmanuel Naline, Christophe Faisy, Sabine Blouquit-Laye, Louis-Jean Couderc, Morgan Le Guen, Marc Fischler, Philippe Devillier
Journal: Pharmacology & Therapeutics (2012)
Early warning and prevention of pneumonia in acute leukemia by patient education, spirometry, and positive expiratory pressure: A randomized controlled trial
Authors: Tom Møller, Claus Moser, Lis Adamsen, Grith Rugaard, Mary Jarden, Tina S. Bøtcher, Liza Wiedenbein, Lars Kjeldsen
Journal: American Journal of Hematology (2015)

Long‐lasting neutropenia associated with acute myeloid leukemia (AML) and its treatment gives rise to a high risk of pneumonia. The use of broad‐spectrum antibiotic prophylaxis during outpatient management has not completely protected patients against admission due to infections and neutropenic fever, emphasizing the need to approach infection protection with complementary efforts. In a randomized controlled design, we examined the applicability of patient‐performed daily spirometry [forced expiratory volume in one second (FEV1)] as an early warning tool and explored the effectiveness of positive expiratory pressure (PEP) in preventing pneumonia among 80 AML patients. Twenty‐five incidences of pneumonia were detected among 23 patients (6 interventions, 17 controls), giving a prevalence of 28.75% during 5420 days of observation. We found a significant difference in incidence between intervention versus control group (2.17 per 1000 days vs. 6.52 per 1000 days, P = 0.021, respectively). A cross point at 80‐76% of the personal FEV1 reference value showed high sensitivity and specificity on pneumonia development. Our data demonstrate the feasibility of educating AML patients in their continuous daily measurement of FEV1 and use of PEP. Daily measures of FEV1 may be an important early warning tool for assessment of pulmonary deterioration during critical phases of neutropenia. We suggest that strategic patient education in the use of spirometry and PEP should be part of standard of care for AML patients undergoing induction chemotherapy. Am. J. Hematol. 91:271–276, 2016. © 2015 The Authors. American Journal of Hematology Published by Wiley Periodicals, Inc.
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects
Authors: Yang Zhou, Tobias Kaiser, Patrícia Monteiro, Xiangyu Zhang, Marie. S. Van der Goes, Dongqing Wang, Boaz Barak, Menglong Zeng, Chenchen Li, Congyi Lu, Michael Wells, Aldo Amaya, Shannon Nguyen, Michael Lewis, Neville Sanjana, Yongdi Zhou, Mingjie Zhang, Feng Zhang, Zhanyan Fu, Guoping Feng
Journal: Neuron (2015)
Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons
Authors: Olga Golonzhka, Alex Nord, Paul L.F. Tang, Susan Lindtner, Athena R. Ypsilanti, Elisabetta Ferretti, Axel Visel, Licia Selleri, John L.R. Rubenstein
Journal: Neuron (2015)
An<i>in vivo</i>model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits
Authors: P. Isedeh, I. Kohli, M. Al-Jamal, O.N. Agbai, M. Chaffins, S. Devpura, M. Mahan, G. Vanderover, H.W. Lim, M.S. Matsui, I.H. Hamzavi
Journal: British Journal of Dermatology (2015)

Journal Article An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits Get access P. Isedeh, P. Isedeh Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital, New Center One 3031 West Grand Blvd Suite 800 Detroit MI 48202 U.S.A Search for other works by this author on: Oxford Academic Google Scholar I. Kohli, I. Kohli Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital, New Center One 3031 West Grand Blvd Suite 800 Detroit MI 48202 U.S.A Search for other works by this author on: Oxford Academic Google Scholar M. Al‐Jamal, M. Al‐Jamal Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital, New Center One 3031 West Grand Blvd Suite 800 Detroit MI 48202 U.S.A Search for other works by this author on: Oxford Academic Google Scholar O.N. Agbai, O.N. Agbai Department of Dermatology University of California, Davis Sacramento CA U.S.A Search for other works by this author on: Oxford Academic Google Scholar M. Chaffins, M. Chaffins Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital, New Center One 3031 West Grand Blvd Suite 800 Detroit MI 48202 U.S.A Search for other works by this author on: Oxford Academic Google Scholar S. Devpura, S. Devpura Department of Radiation Oncology Henry Ford Hospital, New Center One 3031 West Grand Blvd Suite 800 Detroit MI 48202 U.S.A Search for other works by this author on: Oxford Academic Google Scholar M. Mahan, M. Mahan Department of Public Health Sciences Henry Ford Hospital, New Center One 3031 West Grand Blvd Suite 800 Detroit MI 48202U.S.A Search for other works by this author on: Oxford Academic Google Scholar G. Vanderover, G. Vanderover Estée Lauder Companies Melville NY U.S.A Search for other works by this author on: Oxford Academic Google Scholar H.W. Lim, H.W. Lim Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital, New Center One 3031 West Grand Blvd Suite 800 Detroit MI 48202 U.S.A Search for other works by this author on: Oxford Academic Google Scholar M.S. Matsui, M.S. Matsui Estée Lauder Companies Melville NY U.S.A Search for other works by this author on: Oxford Academic Google Scholar ... Show more I.H. Hamzavi I.H. Hamzavi Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital, New Center One 3031 West Grand Blvd Suite 800 Detroit MI 48202 U.S.A Correspondence Iltefat H. Hamzavi. E‐mail: ihamzav1@hfhs.org Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 174, Issue 4, 1 April 2016, Pages 862–868, https://doi.org/10.1111/bjd.14184 Published: 01 April 2016
P-256 An open-label trial to assess the safety of regorafenib in Turkish patients with metastatic colorectal cancer (mCRC) that progressed on standard therapy (REGARD)
Authors: F. Dane, K. Ozgurdal, S. Yalcin, M. Benekli, N.F. Aykan, I. Yucel, M. Ozkan, T. Evrensel, A. Sevinc, H.S. Coskun, U.S. Sanli, I.O. Kara
Journal: Annals of Oncology (2015)
Health Policy and Medical Training
Authors: Rachel J. Stern
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell–Mediated Tumor Control in the Genital Tract
Authors: Yun-Yan Sun, Shiwen Peng, Liping Han, Jin Qiu, Liwen Song, Yachea Tsai, Benjamin Yang, Richard B.S. Roden, Cornelia L. Trimble, Chien-Fu Hung, T.-C. Wu
Journal: Clinical Cancer Research (2015)

Two viral oncoproteins, E6 and E7, are expressed in all human papillomavirus (HPV)-infected cells, from initial infection in the genital tract to metastatic cervical cancer. Intramuscular vaccination of women with high-grade cervical intraepithelial neoplasia (CIN2/3) twice with a naked DNA vaccine, pNGVL4a-sig/E7(detox)/HSP70, and a single boost with HPVE6/E7 recombinant vaccinia vaccine (TA-HPV) elicited systemic HPV-specific CD8 T-cell responses that could traffic to the lesion and was associated with regression in some patients (NCT00788164).Here, we examine whether alteration of this vaccination regimen by administration of TA-HPV vaccination in the cervicovaginal tract, rather than intramuscular (IM) delivery, can more effectively recruit antigen-specific T cells in an orthotopic syngeneic mouse model of HPV16(+) cervical cancer (TC-1 luc).We found that pNGVL4a-sig/E7(detox)/HSP70 vaccination followed by cervicovaginal vaccination with TA-HPV increased accumulation of total and E7-specific CD8(+) T cells in the cervicovaginal tract and better controlled E7-expressing cervicovaginal TC-1 luc tumor than IM administration of TA-HPV. Furthermore, the E7-specific CD8(+) T cells in the cervicovaginal tract generated through the cervicovaginal route of vaccination expressed the α4β7 integrin and CCR9, which are necessary for the homing of the E7-specific CD8(+) T cells to the cervicovaginal tract. Finally, we show that cervicovaginal vaccination with TA-HPV can induce potent local HPV-16 E7 antigen-specific CD8(+) T-cell immune responses regardless of whether an HPV DNA vaccine priming vaccination was administered IM or within the cervicovaginal tract.Our results support future clinical translation using cervicovaginal TA-HPV vaccination.
The course of psychiatric disorder, III: Longitudinal principles
Authors: J S Strauss, H Hafez, P Lieberman, C M Harding
Journal: American Journal of Psychiatry (1985)

The authors studied 28 patients hospitalized for functional psychiatric disorder in an attempt to explore systematically the course of psychiatric disorder. Data collected over the 2-year period following discharge suggested the existence of eight longitudinal principles for understanding the course of psychiatric disorder. These principles reflect identifiable phases and some of the factors involved in a patient's remaining in one phase or moving on to a new phase. The clinical and research implications of these principles are described.
Face Processing Systems: From Neurons to Real-World Social Perception
Authors: Winrich Freiwald, Bradley Duchaine, Galit Yovel
Journal: Annual Review of Neuroscience (2016)

Primate face processing depends on a distributed network of interlinked face-selective areas composed of face-selective neurons. In both humans and macaques, the network is divided into a ventral stream and a dorsal stream, and the functional similarities of the areas in humans and macaques indicate they are homologous. Neural correlates for face detection, holistic processing, face space, and other key properties of human face processing have been identified at the single neuron level, and studies providing causal evidence have established firmly that face-selective brain areas are central to face processing. These mechanisms give rise to our highly accurate familiar face recognition but also to our error-prone performance with unfamiliar faces. This limitation of the face system has important implications for consequential situations such as eyewitness identification and policing.
Combined immunodeficiency due to JAK3 mutation in a child presenting with skin granuloma
Authors: Alessia Scarselli, Silvia Di Cesare, Gigliola Di Matteo, Arianna De Matteis, Paola Ariganello, Maria Luisa Romiti, Simona Cascioli, Rita De Vito, Alice Bertaina, Franco Locatelli, H. Bobby Gaspar, Alessandro Aiuti, Paolo Rossi, Kimberly Gilmour, Caterina Cancrini
Journal: Journal of Allergy and Clinical Immunology (2015)
News
Authors: P O'Neill
Journal: BMJ (1990)

Global medicine on your doorstepTravel may broaden the mind, but it carries serious health risks, too-and not only for refugees.So learnt the participants at the first international migration conference, held in Geneva last month under the auspices of the International Organisation for Migration and the World Health Organisation.Ever alert to the perils of foreign travel, Westerners may be surprised to learn that they are now high on the list of spreaders of disease.International travellers and tourists spend at least 36 billion nights in someone else's bed each year.Small wonder then that Europe's epidemic of sexually transmitted diseases-such as chlamydia and genital herpes-has meant that package tourists are spreading them among locals in new tourist areas such as west Africa.Furthermore, the potcntial flood of east European migrant workers plus the effects of border relaxations in the European Community in 1992 will mean a potential epidemic among the migrants, especially those unaccustomed to regular use of condoms.
Malignant lymphoid polyp – a new category of disease in the large intestine
Authors: Nicole Max, Franz Siebert, Cord Langner
Journal: Endoscopy (2015)

The gastrointestinal (GI) tract is a common site of presentation of extranodal lymphomas, although primary GI lymphomas account for only 5 % to 10 % of primary GI neoplasms. The majority of cases occur in the stomach; only approximately 10 % occur in the colorectum. Diffuse large B-cell lymphoma is the most common type of GI tract lymphoma [1].
The Magical Field of Dermatology
Authors: Vidhi V. Shah, Adam S. Aldahan, Stephanie Mlacker, Mohammad Alsaidan, Keyvan Nouri
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Early vascular assessment should be carried out
Authors: S. Ghauri, I. Nyamekye, K. Poskitt, J R Farndon
Journal: BMJ (1996)

ately referred for vascular surgical or dermatological care.They do not state how many patients were in this category, what their definition of failure of progression of healing was, and whether these more difficult patients referred elsewhere were included in the final analysis of healing rates.If patients with an ankle-brachial pressure index of <0.5 were referred on, were they considered to have severe ischaemia and therefore excluded from the analysis?Studies that purport to show improvements in care and financial savings for the health service are most welcome, but if this is evidence based medicine we should be permitted to see the evi- dence.
Abstract #2337: Effect of curcumin on human esophageal cancer cell lines
Authors: Roudabeh Jamasbi, Taghreed Almanaa, Michael Geusz
Journal: Cancer Research (2009)

The growth of cancer cell lines is inhibited by curcumin, a major constituent of the spice turmeric. Equally important, curcumin has little or no effect on non-transformed cells. Because of the great diversity of cancer cell types that have been tested with curcumin, we chose to evaluate multiple cancer cell lines and determined their responses to a range of curcumin concentrations. We asked whether the sensitivity of these lines to curcumin would correlate with their growth characteristics. A standard crystal violet method provided rapid screening of over a dozen cancer cell lines treated with 5 to 40 \#956;M curcumin, allowing us to rank the lines by sensitivity. All but one line showed a decline in growth with dosage. Greater than 80% of the lines showed a significant reduction in cell growth in response to 40 \#956;M curcumin by ANOVA (p  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2337.
Blood transfusion: summary of NICE guidance
Authors: S. Padhi, S. Kemmis-Betty, S. Rajesh, J. Hill, M. F. Murphy
Journal: BMJ (2015)

#### What you need to know Although blood transfusion is common in clinical practice, it is associated with some risk. Alternatives to blood transfusion are also underused.1 Audits in the United Kingdom show that the inappropriate use of blood components is 20% or more.2 This puts patients at unnecessary risk of receiving the wrong blood and of complications such as circulatory overload and transfusion related acute lung injury, as well as wasting a scarce and costly resource. Measures for managing patients without blood transfusion are underused.1 This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE) on blood transfusion.3 #### What's new in this guidance NICE recommendations are based on systematic reviews of the best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations are based on the Guideline Development Group's experience and opinion of what constitutes good practice. Evidence levels for the recommendations are given in italic in square brackets. ### Alternatives to blood transfusion for patients having surgery #### Erythropoietin
Integrated, proactive laboratory based approach is effective
Authors: R Wilmot, J Banks, M C Galvin
Journal: BMJ (1996)

EDITOR,—We recognise many of the problems outlined by D A Fitzmaurice and colleagues in their editorial on monitoring oral anticoagulant treatment in primary care but think that they are unlikely to be resolved in primary care.1 Lack of consistency is not limited to outpatient anticoagulant treatment; it extends to hospital inpatients and the interface between hospitals and the community. Problems include variation in practice between clinical teams, a dangerously long interval between inpatient induction and the first outpatient appointment for measurement of the international normalised …
Chemopotentiation studies with two classes of potent (polyADP-ribose) polymerase (PARP) inhibitors in human lung and colon carcinoma cell lines.
Authors: NJ Curtin, AH Calvert, S Canan-Koch, BW Durkacz, RJ Griffin, BT Golding, Z Hostomsky, S Kyle, J Li, K Maegley, Newell, LZ Wang, SE Webber, A White, XH Yu
Journal: Clinical Cancer Research (2000)
Where are we now with paracetamol?
Authors: James W Dear, Daniel J Antoine, B Kevin Park
Journal: BMJ (2015)

Important questions remain unanswered about the most widely used drug in the UK

When a doctor recommends a new medicine there are questions that a patient would hope to have answered. Will the treatment work for my clinical problem? Are there side effects? How many tablets do I take? Paracetamol was introduced into UK medical practice in 1956. It is the most widely used and prescribed drug in the UK and is generally considered to be effective and safe in therapeutic doses. In recent years, however, studies have raised questions regarding its efficacy and safety.1 2 Where are we with regard to the patient’s three questions?

Paracetamol is recommended in guidelines produced by agencies such as the UK National Institute for Health and Care Excellence. It is an effective mild analgesic but may not work for all types of pain. Paracetamol is effective for postoperative dental pain.3 For headache, it is superior to placebo but less effective than other analgesics.4 For the common cold, the evidence is insufficient to draw conclusions.5 Randomised trial data report that paracetamol is no more effective than placebo for back pain.2 For hip …
Abstract 11249: Differential Cardiac MicroRNA Expression Predicts the Clinical Course in Human Enterovirus Cardiomyopathy
Authors: Wolfgang Poller
Journal: Circulation (2014)

Background: Regarding disease pathogenesis, it has become evident that confinement to analysis of protein-coding regions of the genome is incomplete since many noncoding variants are associated with important human diseases Objectives: Identification of novel molecular predictive markers for the course of human enterovirus (CVB3) cardiomyopathy, and of noncoding elements in the genome influencing the grossly different antiviral capacity of individual patients. Methods: Transcriptome mapping of CVB3 cardiomyopathy patients revealed distinctive cardiac microRNA (miR) patterns associated with either spontaneous virus clearance and recovery (CVB3-ELIM), or virus persistence and progressive clinical deterioration (CVB3-PERS). Profiling of protein-coding genes and 754 miRs in endomyocardial biopsies (EMBs) of test cohorts was performed at their initial presentation, and those spontaneously eliminating the virus were compared to those with virus persistence on follow-up. Results: Initial miR profiling revealed h...