tbuckley/cabot-search huggingface dataset:
AB1195 Our experience with anakinra treatment in a tertiary centre:
Authors: S. Murias, A. Remesal, C. Salido, B. Vacas, A. Mendez, J.I. Arostegui, R. Merino
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Anakinra (ANK) is a recombinant interleukin-1 receptor antagonist currently used for treating autoinflammatory syndromes. <h3>Objectives</h3> To describe patient characteristics and their response to ANK in a tertiary centre between 2004 and 2011. <h3>Methods</h3> Retrospective study of 35 children treated with ANK. Demographic, clinical, analytical and genetic data were recorded. They were considered as responders when they reached analytic and clinical normalization and corticosteroids could then be discontinued. <h3>Results</h3> The sample included 21 boys and 14 girls, aged 3 days - 13 years old. Patient characteristics and response to ANK are summarised in the table [(values are expressed as n (%), median, mean (minimum-maximum)]. Responders were older at disease onset (p=0.032) and showed a high number of neutrophils (p=0.002). Nineteen (54%) cases met the criteria for systemic-onset juvenile idiopathic arthritis (SoJIA), 10 of them responded and their median time to start treatment was 1.6 years, being 4.5 for non-responders. Sixteen (46%) children did not meet the criteria for SoJIA, and 8 responded. The median time to start ANK in this group was 0.9 years for responders and 1.1 for non-responders respectively. Genetic testing performed in 27 patients showed mutation in 14 (8 MEFV, 2 TNRFSF1A, 2 NLRP3, 1 MVK y 1 NOD2), 6 of them were responders (4 MEFV, 1 NLRP3 y 1 MVK). <h3>Conclusions</h3> In spite of study limitations, responders were older at disease onset and showed a higher number of neutrophils. Moreover, it seems that patients with SoJIA who had the shortest time of evolution responded better than those with longer disease duration. <h3>References</h3> The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis. Gattorno M et al. Arthritis Rheum 2008;58:1505-15. Anakinra: a safe and effective first-line treatment in systemic onset juvenile idiopathic arthritis (SoJIA). Hedrich CM et al. Rheumatol Int 2011 Nov 15 (Epub ahead of print). <h3>Disclosure of Interest</h3> None Declared
EFFECT OF GENE POLYMORPHISM OF GNB3 ON THE RISK OF HIGH-NORMAL BLOOD PRESSURE IN A JAPANESE POPULATION
Authors: Masahiko Eto, Masanobu Okayama, Taro Takeshima, Maki Kumada, Takanori Aonuma, Yoshikazu Nakamura, Eiji Kajii
Journal: Journal of the American College of Cardiology (2016)
FRI0287 Proliferative nephritis forms in sle patients with minimal proteinuria and high sledai
Authors: M. A. Spinetto, C. M. Pappalardo, J. P. Vinicki, V. C. Cruzat, M. De Rosa, D. Dubinsky, A. Marini, G. Nasswetter
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> ACR and EULAR guidelines recommend performing renal biopsy in every SLE patient with proteinuria above 0,5g/24h. Some patients show an active urine analysis with dysmorphic erythrocytes but proteinuria &lt; 0,5g/24h. <h3>Objectives</h3> To analyzed clinical manifestations, SLEDAI and histological classes found in patients with SLE and proteinuria &lt;0,5g/24h without renal insufficiency <h3>Methods</h3> Retrospective study of 33 adult patients with SLE (ACR 1997) and proteinuria &lt;0,5g/24h, were evaluated between 1995 and 2010 in the Division of Nephrology and Rheumatology at Clinical Hospital Jose San Martín. There were performed 192 biopsies, 35/192 (18%) had low proteinuria, but 2 were excluded due to renal insufficiency. We analyzed clinical manifestations and SLEDAI at the time of renal biopsy. All renal samples were studied by light microscopy and immunofluorescence and were classified according to the ISN RPS 2003. Data were analyzed using SPSS 17.0 program. <h3>Results</h3> There were 25 women (76%) and 8 men (24%), average age of 34 years (19-65) IQR 17. Median of disease: 120 months (36-264) IQR 96. Cutaneous involvement was found in 28 patients (84.8%), arthritis in 21 (63.6%), hematological features in 17 (51.5%), serositis in 9 (27.3%), and no patient had neurological criteria. Anti DNA was positive in 24 patients (72.7%) and hypocomplementemia 20 (60.6%). Mean SLEDAI was 15 (DS 6.06). <h3>Conclusions</h3> We found high prevalence of proliferative forms in SLE patients with low proteinuria (&lt; 0,5g/24h). As mean SLEDAI was high in this cohort, patients frequently required moderate/high steroids doses. We hypothesized that the absence of mesangial forms and low proteinuria were probably related to this fact. These findings could suggest renal biopsy in lupus patients with glomerular hematuria and proteinuria &lt; 0,5g/24h. SLEDAI is a tool that could be useful in the decision to perform renal biopsy. <h3>References</h3> George K Bertsias et al, Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis, Ann Rheum Dis 2012;71:1771–1782. Hahn BH et al, American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis, Arthritis Care Res 2012 Jun; 64(6):797-808. Sociedad Argentina de Reumatología y Sociedad Argentina de Nefrología, Primer Consenso Argentino sobre Diagnóstico y Tratamiento de la Nefropatía Lúpica, Rev Arg Reumatol. 2011; 22 (4): 06-37. <b>Disclosure of Interest</b>: None Declared
SAT0148 Does depression affect response to anti-tumour necrosis factor-α therapy in patients with rheumatoid arthritis (RA)? Results from the british society for rheumatology biologics register (BSRBR):
Authors: R. Davies, L.K. Mercer, J.B. Galloway, A.S. Low, K.D. Watson, M. Lunt, D.P. Symmons, K.L. Hyrich
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Depression is widely reported in RA, with prevalence estimates at 14-46%. Several studies have suggested that RA patients with persistent depression have poorer response to anti-TNF therapy. <h3>Objectives</h3> To investigate the effects of depression status at baseline in patients with RA on (1) response to anti-TNF therapy at 6 months, and (2) survival rates on first anti-TNF drug. <h3>Methods</h3> 8899 patients with RA starting their first anti-TNF and enrolled in the BSRBR were included in this analysis. Data was collected at baseline and 6 monthly for 3 years from the hospital (including 28 joint count disease activity score (DAS28)), comorbidity, anti-rheumatic drug use (start/stop dates and reasons for discontinuation) and current medication use) and the patients (Health Assessment Questionnaire (HAQ)). Depression was defined at baseline as no history (ND), depression history without current medication (D), or depression with current medication (CM). Response to anti-TNF at 6-months was defined using (1) EULAR response criteria (none versus moderate or good) and (2) achieving &gt;0.22 improvement in HAQ. Multivariate logistic regression was used to study the effect of depression on response. Discontinuation of anti-TNF was compared using Cox Regression. <h3>Results</h3> Depressed patients were younger, proportionally more female with similar disease severity (Table). Co-morbidity rates were higher in depressed patients, particularly those taking medication. There was no difference in overall DAS28 response between the groups. However, depressed patients were less likely to achieve a clinically significant improvement in HAQ. Survival rates on drug were not affected by depression D HR 1.01 (0.92, 1.12) CM HR 1.00 (0.88, 1.13). <h3>Conclusions</h3> Patients with baseline depression were less likely to achieve a clinically important improvement in HAQ at 6 months, with no difference in DAS28 response, suggesting it may be subjective measures of disease and ultimately response that are affected by patient depression. Drug survival was not affected by depression suggesting that anti-TNF therapy is still effective in these patients. <h3>Disclosure of Interest</h3> None Declared
Fluorine-18 FDG Myocardial Positron Emission Tomographic Findings Before and After Pituitary Adenoma Resection in a Patient with Acromegalic Cardiomyopathy
Authors: NAOKI TOKITA, SHINJI HASEGAWA, MITSUO HIRATA, JUN YOSHIOKA, HITOSHI YAMAGUCHI, MASATSUGU HORI, TSUNEHIKO NISHIMURA
Journal: Clinical Nuclear Medicine (2000)

Because of persistently elevated growth hormone levels, acromegaly gives rise to various changes in organs mediated by insulin-like growth factor-I. In the heart, it causes myocardial hypertrophy, and, with time, heart failure. The authors performed pituitary adenomectomy in a patient with acromegalic cardiomyopathy who had heart failure; after operation, the blood growth hormone levels decreased to within the normal range and there was a marked improvement in left ventricular function by gated blood pool scintigraphy. Pre- and postoperative fluorine-18 fluorodeoxyglucose (FDG) myocardial positron emission tomography showed increased accumulation of FDG in the myocardium before surgery, but accumulation within the normal range after operation. Myocardial glucose metabolism changed when the long-term effects of growth hormone and insulin-like growth factor-I were eliminated, and this appears to be accurately reflected by FDG positron emission tomography.
Detection of Bacterial Deconjugation of Bile Salts by a Convenient Breath-Analysis Technic
Authors: Howard P. Sherr, Yasuhito Sasaki, Alvin Newman, John G. Banwell, Henry N. Wagner, Thomas R. Hendrix
Journal: New England Journal of Medicine (1971)

When glycine-1–14C-cholate was given orally and 14CO2 specific activity of expired air measured by a breath-analysis technic, the results clearly separated patients with either ileal resection or bacterial-overgrowth syndromes from subjects without abnormalities of bile-salt metabolism. The normal subjects and the patients with steatorrhea unrelated to abnormalities of bile-salt metabolism had no appreciable rise in 14CO2 excretion (2.2 ± 0.60 [S.E.] and 1.3 ± 0.31 per cent administered dose, respectively) whereas subjects with ileal resection and bacterial-overgrowth syndromes had a rapid appearance of 14CO2 in expired breath (31.4 ± 4.62 and 23.4 ± 6.78 per cent of administered dose, respectively). Elimination of bacterial overgrowth with antibiotics or surgical fistula repair returned 14CO2 excretion (0.7 ± 0.23 per cent) to normal. Thus, the breath test will detect increased bacterial deconjugation of bile salts and assess effective antibiotic management of bacterial-overgrowth syndromes.
STATIN INTOLERANCE IS ASSOCIATED WITH INCREASED RISK FOR RECURRENT CORONARY HEART DISEASE HOSPITALIZATIONS
Authors: Shia T. Kent, Corina Serban, Paul Muntner, Lisandro Colantonio, Keri Monda, Ligong Chen, Lei Huang, Vera Bittner, Angelika Manthripragada, Ricardo Dent, Robert Rosenson
Journal: Journal of the American College of Cardiology (2016)
AB0434 Antibody to dsdna (anti-dsdna), circulating immune complex (cic) in systemic lupus erithematosus (sle) and antiphospholipid syndrome (aps)
Authors: T. Reshetnyak, E. N. Alexandrova, N. V. Seredavkina, Z. G. Verizhnikova, E. L. Nasonov
Journal: Annals of the Rheumatic Diseases (2013)

This study addresses an important gap in the stated preference literature concerning valence-based framing of discrete choice experiment attributes. Valence-based framing arises when equivalent outcomes are presented in different ways by accentuating either the positive (e.g., more in good condition) or negative information (e.g., less in bad condition). We find that alternative framings produce different willingness-to-pay estimates, with implications for Benefit-Cost Analysis. We recommend neutral attribute descriptions and otherwise testing for the impacts of alternative framings to obtain more robust welfare evidence. We also show that the framing used does not affect the choice paradigm adopted by respondents.
AB1057 Osteoporosis in calcium pyrophosphate deposition disease:
Authors: F. Kudaeva, S. Vladimirov, V. Barskova
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To study the frequency of osteoporosis (OP) in patients with calcium pyrophosphate deposition disease (CPPD). <h3>Methods</h3> 85 pts with crystal-proven diagnosis of CPPD and chondrocalcinosis phenomena, confirmed either by conventional radiography (Rg) or by ultrasonography (US) of the joints, were enrolled. Following investigations were performed in pts: Rg and US of the knees and wrists, dual x ray absorptiometry (DXA) of the forearm, femoral neck and lumbar spine. Blood analysis included detection of hsCRP, parathyroid hormone, calcium, magnesium, phosphorus levels, and detection of 24-urinary excretion of calcium and phosphorus. Based on the results of bone mineral density (BMD) the pts were diagnosed with OP (N score lower -2,5 SD), osteopenia (N score between -1 and -2,5 SD), revealed at least in one area. Normal BMD was defined as a T score above -1 SD. According to the level of BMD pts were divided into 3 groups: 1gr - pts with normal BMD (n=34), 2 gr – pts with osteopenia (n=38), 3 gr – pts with OP (n=13). <h3>Results</h3> There was no difference in age between pts in three groups (56,26±12,16 ys in the 1st, 58,33±9,03 ys in the 2nd and 66,15±14,44 ys in the 3d group, d=0,33). There was prevalence of male in the 1st group (62%), in the 2nd group the number of male and female was the same, in the 3d group number of female were higher (62%) (d=0,06). Contributed to the development of BMD changes in pts with CPPD, risk factors appeared to be diuretics intake, hyperparathyroidism (HPT) and fractures. Table 1 shows the frequency of risk factors in pts with CPPD. Data shows high frequency of HPT and fractures in pts in the 2nd and 3d group. No difference was recorded in calcium, phosphorus and magnesium serum levels between pts in 3 groups. Level of 24-hour urinary phosphorus excretion appeared to be lower in pts in the 3d group (27,2±14,47 mcmol/24h, 26,37±11,57 mcmol/24h and 17,38±12,41 mcmol/24h in pts of 1st, 2nd and 3d group, correspondingly, d&lt;0,05). <h3>Conclusions</h3> Taking diuretics was registered more often in patients with CPPD and OP detected at least in one area. HPT as a risk factor of CPPD occurred in patients with both osteopenia and OP. Presence of bone fractures occurred more frequently in patients with OP. <h3>Disclosure of Interest</h3> None Declared
Geographical distribution and epidemiological characteristics of visceral leishmaniasis in Bulgaria, 1988 to 2012
Authors: R Harizanov, I Rainova, N Tzvetkova, I Kaftandjiev, I Bikov, O Mikov
Journal: Eurosurveillance (2013)

Visceral leishmaniasis is a sporadic illness in Bulgaria. However, cases in humans are registered nearly every year. This study describes the geographical distribution of the disease in Bulgaria from 1988 to 2012, over a period of 25 years. Cases were analysed according to age, sex, and place of residence. A total of 122 cases were registered in 25 years, 118 of which were autochthonous and four of which were imported from endemic countries in southern Europe. The average annual incidence for the study period was 0.06 per 100,000 population, or an average of five cases per year (maximum 15 in 1989; no cases notified in 1991, 1995, 1996 and 2008). Cases of visceral leishmaniasis were recorded in 13 out of 28 regions in Bulgaria, mainly in the southern part of the country. The highest number of cases were registered in the regions of Blagoevgrad (n=36) and Stara Zagora (n=34). Data presented in this study show that there is ongoing transmission of visceral leishmaniasis in Bulgaria with a high mortality rate (1:7), affecting mostly children.
THU0411 Utility of ultrasound scores in assessment enthesitis on anti-TNF therapy of spondyloarthritis patients:
Authors: A.M. Istrate, E. de Miguel, I. Felea, M.Ά. Caracuel Ruíz, E. Collantes-Estevéz
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Entheses affectation is the hallmark lesions in ankylosis spondylitis (AS). In front of the cardinal role of enthesis inflammation on SpA is the finding that clinical examination lacks sensitivity and specificity, as has been demonstrated by several studies comparing clinical evaluations with new imaging techniques as ultrasound (US). <h3>Objectives</h3> To explore the utility and concurrent validity of enthesis US MASEI score in SpA patients with anti-TNF therapy. <h3>Methods</h3> Thirty four patients with AS, fulfilling modified New York criteria in treatment with biologic therapy were enrolled. All patients underwent a clinical evaluation, following up: the AS-specific scores Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankyosing Spondylitis Functional Index (BASFI) and the enthesitis-specific scores MASES. Laboratory data included inflammatory parameters (ESR and CRP). Ultrasound evaluation.The MASEI US score was applied to every patient. The MASEI score is a weighted score previously calculated by logistic regression that overestimates the score of three elemental lesions: calcification (0-3), Doppler (0 or 3), erosion (0 or 3), while scoring tendon structure, tendon thickness and bursa is either a 0 or 1. The score range is between 0 and 136. <h3>Results</h3> Thierty four patients, 21 (61%) men and 13 (39%) women with a mean age of 44.5±9.5 (range, 32-59) were enrolled. The patients had a mean of disease duration of 10.36±6.86 years and a mean duration of biologic therapy was 50±31.5 months. Laboratory tests indicated high level of ESR and CRP were in 10 (31%) patients: mean ESR was 16.38±18.9 (range, 2-100) and mean serum CRP was 9.92±20.09 (range, 1-84.3). Thierty two patients (93.7%) were HLA-B27 positive and two patients (6.2%) was negative. BASDAI score was &gt;4) in 38,2% of patients and MASES score &gt;0 at 22 patients (64,7%) at the moment of the US examination. <h3>Conclusions</h3> All ultrasound elemental lesions had lower scores in BASDAI responders but only Doppler signal was a significant difference and completely disappear in anti-TNF responder SpA patients. If this is confirmed by others Doppler signal can became and useful measure to asses enthesitis in SpA. <h3>Disclosure of Interest</h3> None Declared
Variation in Quality of Urgent Health Care Provided During Commercial Virtual Visits
Authors: Adam J. Schoenfeld, Jason M. Davies, Ben J. Marafino, Mitzi Dean, Colette DeJong, Naomi S. Bardach, Dhruv S. Kazi, W. John Boscardin, Grace A. Lin, Reena Duseja, Y. John Mei, Ateev Mehrotra, R. Adams Dudley
Journal: JAMA Internal Medicine (2016)

<h3>Importance</h3> Commercial virtual visits are an increasingly popular model of health care for the management of common acute illnesses. In commercial virtual visits, patients access a website to be connected synchronously—via videoconference, telephone, or webchat—to a physician with whom they have no prior relationship. To date, whether the care delivered through those websites is similar or quality varies among the sites has not been assessed. <h3>Objective</h3> To assess the variation in the quality of urgent health care among virtual visit companies. <h3>Design, Setting, and Participants</h3> This audit study used 67 trained standardized patients who presented to commercial virtual visit companies with the following 6 common acute illnesses: ankle pain, streptococcal pharyngitis, viral pharyngitis, acute rhinosinusitis, low back pain, and recurrent female urinary tract infection. The 8 commercial virtual visit websites with the highest web traffic were selected for audit, for a total of 599 visits. Data were collected from May 1, 2013, to July 30, 2014, and analyzed from July 1, 2014, to September 1, 2015. <h3>Main Outcomes and Measures</h3> Completeness of histories and physical examinations, the correct diagnosis (vs an incorrect or no diagnosis), and adherence to guidelines of key management decisions. <h3>Results</h3> Sixty-seven standardized patients completed 599 commercial virtual visits during the study period. Histories and physical examinations were complete in 417 visits (69.6%; 95% CI, 67.7%-71.6%); diagnoses were correctly named in 458 visits (76.5%; 95% CI, 72.9%-79.9%), and key management decisions were adherent to guidelines in 325 visits (54.3%; 95% CI, 50.2%-58.3%). Rates of guideline-adherent care ranged from 206 visits (34.4%) to 396 visits (66.1%) across the 8 websites. Variation across websites was significantly greater for viral pharyngitis and acute rhinosinusitis (adjusted rates, 12.8% to 82.1%) than for streptococcal pharyngitis and low back pain (adjusted rates, 74.6% to 96.5%) or ankle pain and recurrent urinary tract infection (adjusted rates, 3.4% to 40.4%). No statistically significant variation in guideline adherence by mode of communication (videoconference vs telephone vs webchat) was found. <h3>Conclusions and Relevance</h3> Significant variation in quality was found among companies providing virtual visits for management of common acute illnesses. More variation was found in performance for some conditions than for others, but no variation by mode of communication.
P863 A SIMPLE MODEL TO PREDICT 5-YEAR MORTALITY AFTER LIVER TRANSPLANTATION IN PATIENTS WITH END-STAGE LIVER DISEASE
Authors: F.S. Cardoso, S.M. Bagshaw, J.G. Abraldes, N. Kneteman, G. Meeberg, P. Fidalgo, C.J. Karvellas
Journal: Journal of Hepatology (2014)