tbuckley/cabot-search huggingface dataset:
His Bundle Electrograms in Patients with Short P-R Intervals, Narrow QRS Complexes, and Paroxysmal Tachycardias
Authors: AGUSTIN CASTELLANOS, CECAR A. CASTILLO, ABDUL S. AGHA, MICHAEL TESSLER
Journal: Circulation (1971)

His bundle electrograms were recorded in three patients with short P-R intervals, narrow QRS complexes, and a history of paroxysmal tachycardias. During sinus rhythm or atrial stimulation with long cycle lengths, the shortening of the P-R interval was due to a decrease in the low right atrium-His (LRA-H) interval (representing A-H conduction time). The latter was also short during retrograde (V-A) conduction. These findings support the existence of an A-V nodal bypass operation in both directions. In one patient, the LRA-H interval did not lengthen when the atrial rate was increased. Intermittent atrial pacing was performed in the two other patients. The LRA-H interval was short at long coupling intervals, but it started to increase (progressively) at a given Stimulus 1 -Stimulus 2 interval. Apparently, the refractory period of the accessory bundle was encountered so that the impulse was propagated, with various degrees of delay, through the A-V node. A James bundle need not be present in all patients with similar electrocardiograms. Abnormalities of unknown origin could cause this phenomenon. Reciprocating tachycardias were induced by stimulation of the atria in one patient. The triggering beat consistently had a long A-V conduction time. Although in this case retrograde (V-A) propagation most probably occurred through the accessory communication, the possibility of a functional intranodal dissociation of a single anatomical pathway could not be excluded.
Erratum to: Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma
Authors: Deborah JL Wong, Lidia Robert, Mohammad S Atefi, Amanda Lassen, Geetha Avarappatt, Michael Cerniglia, Earl Avramis, Jennifer Tsoi, David Foulad, Thomas G Graeber, Begonya Comin-Anduix, Ahmed Samatar, Roger S Lo, Antoni Ribas
Journal: Molecular Cancer (2015)

Deborah JL Wong and Lidia Robert contributed equally to this work.



The online version of the original article can be found under doi:10.1186/1476-4598-13-194.
Non-specific effects of acupuncture – Does the ‘placebo’ effect play an important role?: Table 1
Authors: Christopher Michael Williams, Steve J Kamper
Journal: British Journal of Sports Medicine (2012)

▶ Linde K, Niemann K, Schneider A, et al. BMC Med 2010;8:75 http://www.biomedcentral.com/1741-7015/8/75 (accessed 23 November 2010)[OpenUrl][1][CrossRef][2][PubMed][3] Evidence for specific effects of acupuncture that are clinically relevant remains contentious. When compared with no treatment, acupuncture is effective.1 However, in comparison to sham or placebo acupuncture, there is a greatly reduced treatment effect.2 Thus, the benefit of the treatment may be due to incidental (and unknown) elements of the intervention. These factors have been called 'non-specific' effects; the mechanism is unknown but may be mediated by such factors as patient–practitioner communication, the therapeutic ritual and patient expectations about the treatment. Historically, the term 'placebo effect' has been applied to account for these non-specific effects of treatment. However, despite general acceptance of the term, there remains considerable controversy regarding the definition of 'placebo'. Further, by choosing not to use the term, we favour attempts to move beyond the idea of a placebo as a sort of black box towards elucidation of the elements responsible for its effect. Understanding non-specific treatment effects and integrating these attributes in to practice (eg, enhancing treatment expectations) may help optimise treatment effectiveness. The primary aim was to investigate the size of the non-specific effects of acupuncture. The secondary aim was to investigate factors that influence the size of non-specific effects such as the type of sham intervention, the condition for which the treatment was applied and study quality. Three electronic … [1]: {openurl}?query=rft.jtitle%253DBMC%2Bmedicine%2B%255Belectronic%2Bresource%255D%26rft.stitle%253DBMC%2BMed%26rft.aulast%253DLinde%26rft.auinit1%253DK.%26rft.volume%253D8%26rft.spage%253D75%26rft.epage%253D75%26rft.atitle%253DHow%2Blarge%2Bare%2Bthe%2Bnonspecific%2Beffects%2Bof%2Bacupuncture%253F%2BA%2Bmeta-analysis%2Bof%2Brandomized%2Bcontrolled%2Btrials.%26rft_id%253Dinfo%253Adoi%252F10.1186%252F1741-7015-8-75%26rft_id%253Dinfo%253Apmid%252F21092261%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1186/1741-7015-8-75&link_type=DOI [3]: /lookup/external-ref?access_num=21092261&link_type=MED&atom=%2Fbjsports%2F46%2F8%2F578.atom
Antiangiogenic and Antitumor Effects of Src Inhibition in Ovarian Carcinoma
Authors: Liz Y. Han, Charles N. Landen, Jose G. Trevino, Jyotsnabaran Halder, Yvonne G. Lin, Aparna A. Kamat, Tae-Jin Kim, William M. Merritt, Robert L. Coleman, David M. Gershenson, William C. Shakespeare, Yihan Wang, Raji Sundaramoorth, Chester A. Metcalf, David C. Dalgarno, Tomi K. Sawyer, Gary E. Gallick, Anil K. Sood
Journal: Cancer Research (2006)

Src, a nonreceptor tyrosine kinase, is a key mediator for multiple signaling pathways that regulate critical cellular functions and is often aberrantly activated in a number of solid tumors, including ovarian carcinoma. The purpose of this study was to determine the role of activated Src inhibition on tumor growth in an orthotopic murine model of ovarian carcinoma. In vitro studies on HeyA8 and SKOV3ip1 cell lines revealed that Src inhibition by the Src-selective inhibitor, AP23846, occurred within 1 hour and responded in a dose-dependent manner. Furthermore, Src inhibition enhanced the cytotoxicity of docetaxel in both chemosensitive and chemoresistant ovarian cancer cell lines, HeyA8 and HeyA8-MDR, respectively. In vivo, Src inhibition by AP23994, an orally bioavailable analogue of AP23846, significantly decreased tumor burden in HeyA8 (P = 0.02), SKOV3ip1 (P = 0.01), as well as HeyA8-MDR (P < 0.03) relative to the untreated controls. However, the greatest effect on tumor reduction was observed in combination therapy with docetaxel (P < 0.001, P = 0.002, and P = 0.01, for the above models, respectively). Proliferating cell nuclear antigen staining showed that Src inhibition alone (P = 0.02) and in combination with docetaxel (P = 0.007) significantly reduced tumor proliferation. In addition, Src inhibition alone and in combination with docetaxel significantly down-regulated tumoral production of vascular endothelial growth factor and interleukin 8, whereas combination therapy decreased the microvessel density (P = 0.02) and significantly affected vascular permeability (P < 0.05). In summary, Src inhibition with AP23994 has potent antiangiogenic effects and significantly reduces tumor burden in preclinical ovarian cancer models. Thus, Src inhibition may be an attractive therapeutic approach for patients with ovarian carcinoma.
Bicarbonate Therapy in Severe Metabolic Acidosis
Authors: Sandra Sabatini, Neil A Kurtzman
Journal: Journal of the American Society of Nephrology (2008)

The utility of bicarbonate administration to patients with severe metabolic acidosis remains controversial. Chronic bicarbonate replacement is obviously indicated for patients who continue to lose bicarbonate in the ambulatory setting, particularly patients with renal tubular acidosis syndromes or diarrhea. In patients with acute lactic acidosis and ketoacidosis, lactate and ketone bodies can be converted back to bicarbonate if the clinical situation improves. For these patients, therapy must be individualized. In general, bicarbonate should be given at an arterial blood pH of < or =7.0. The amount given should be what is calculated to bring the pH up to 7.2. The urge to give bicarbonate to a patient with severe acidemia is apt to be all but irresistible. Intervention should be restrained, however, unless the clinical situation clearly suggests benefit. Here we discuss the pros and cons of bicarbonate therapy for patients with severe metabolic acidosis.
Thalamic Volumes in Patients With First-Episode Schizophrenia
Authors: Andrew R. Gilbert, David R. Rosenberg, Keith Harenski, Stephen Spencer, John A. Sweeney, Matcheri S. Keshavan
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: The thalamus, a highly evolved sensory and motor gateway to the cortex, has been implicated in the pathophysiology of several illnesses, including schizophrenia. Several studies have suggested thalamic volume differences in patients with schizophrenia, although only a few studies have examined thalamic structure in new-onset patients. METHOD: The authors used magnetic resonance imaging to measure thalamic volumes in previously untreated patients with first-episode schizophrenia (N=16) relative to those of healthy comparison subjects (N=25). The age range of the patients and comparison subjects was 15 to 45 years of age. Thalamic volumes in the right and left hemispheres were segmented and analyzed, both separately and as total thalamic volume, by a rater blind to clinical data. The thalamus was further segmented into regions that roughly reflected individual thalamic nuclei. Analysis of covariance was used to control for intracranial volume. RESULTS: Right, left, and total thalamic volumes of the patients with schizophrenia were significantly smaller than those of the comparison subjects. Significantly smaller volumes were found in the left central medial subdivision of the patients as well as a smaller volume in the right central medial subdivision that approached significance. These regions primarily comprised the dorsomedial nucleus, a thalamic nucleus thought to be an important component of aberrant circuitry in schizophrenia. Significant volume differences were also seen in the left anterior, right anterior, and right posterior medial subdivisions. CONCLUSIONS: These findings suggest significant thalamic volumetric differences between patients with newly diagnosed schizophrenia and healthy comparison subjects. Future analysis of individual thalamic nuclei may reveal important, specific relationships between thalamic abnormalities and schizophrenia.
Tolerability, safety, pharmacokinetics, and efficacy of doxorubicin-loaded anti-EGFR immunoliposomes in advanced solid tumours: a phase 1 dose-escalation study
Authors: Christoph Mamot, Reto Ritschard, Andreas Wicki, Gregor Stehle, Thomas Dieterle, Lukas Bubendorf, Christoph Hilker, Stefanie Deuster, Richard Herrmann, Christoph Rochlitz
Journal: The Lancet Oncology (2012)
Management of endometrial cancer in Asia: consensus statement from the Asian Oncology Summit 2009
Authors: Siriwan Tangjitgamol, Benjamin O Anderson, Hui Ti See, Chawalit Lertbutsayanukul, Nakarin Sirisabya, Tarinee Manchana, Arunachalam Ilancheran, Khai Mun Lee, Siew Eng Lim, Yin-Nin Chia, Efren Domingo, Young-Tak Kim, Chyong-Huey Lai, Ahmad Zailani Hatta Mohd Dali, Wisit Supakapongkul, Sarikapan Wilailak, Eng-Hseon Tay, John Kavanagh
Journal: The Lancet Oncology (2009)
Characterization and identification of PARM-1 as a new potential oncogene
Authors: Cyndia Charfi, Louis-Charles Levros, Elsy Edouard, Eric Rassart
Journal: Molecular Cancer (2013)

Abstract Background The Graffi murine retrovirus is a powerful tool to find leukemia associated oncogenes. Using DNA microarrays, we recently identified several genes specifically deregulated in T- and B-leukemias induced by this virus. Results In the present study, probsets associated with T-CD8 + leukemias were analyzed and we validated the expression profile of the Parm-1 gene. PARM-1 is a member of the mucin family. We showed that human PARM-1 is an intact secreted protein accumulating predominantly, such as murine PARM-1, at the Golgi and in the early and late endosomes. PARM-1 colocalization with α-tubulin suggests that its trafficking within the cell involves the microtubule cytoskeleton. Also, the protein co-localizes with caveolin-1 which probably mediates its internalization. Transient transfection of both mouse and human Parm-1 cDNAs conferred anchorage- and serum-independent growth and enhanced cell proliferation. Moreover, deletion mutants of human PARM-1 without either extracellular or cytoplasmic portions seem to retain the ability to induce anchorage-independent growth of NIH/3T3 cells. In addition, PARM-1 increases ERK1/2, but more importantly AKT and STAT3 phosphorylation. Conclusions Our results strongly suggest the oncogenic potential of PARM-1.
Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
Authors: Odile Gabay, Hanna Oppenhiemer, Hadar Meir, Kristien Zaal, Christelle Sanchez, Mona Dvir-Ginzberg
Journal: Annals of the Rheumatic Diseases (2012)

A growing body of evidence indicates that the protein deacetylase, SirT1, affects chondrocyte biology and survival. This report aims to evaluate in vivo attributes of SirT1 in cartilage biology of 129/J murine strains.Heterozygous haploinsufficient (SirT1(+/-)) and wild-type (WT; SirT1(+/+)) 129/J mice aged 1 or 9 months were systematically compared for musculoskeletal features, scored for osteoarthritis (OA) severity, and monitored for chondrocyte apoptosis in articular cartilage. Sections of femorotibial joints were stained for type II collagen and aggrecan. Protein extracts from articular chondrocytes were isolated and immunoblotted for SirT1 and active caspase 3.Phenotypic observations show that, at 1 month of age, SirT1(+/-) mice were smaller than WT and showed a significant decrease in full-length SirT1 (FLSirT1; 110 kDa) protein levels. Levels of FLSirT1 were further decreased in both strains at 9 months. Immunoblot assays for 9-month-old strains revealed the presence of the inactive cleaved SirT1 variant (75 SirT1; 75 kDa) in WT mice, which was undetected in age-matched SirT1(+/-) mice. Nine-month-old SirT1(+/-) mice also showed increased OA and increased levels of apoptosis compared with age-matched WT mice.The data suggest that the presence of 75 SirT1 may prolong viability of articular chondrocytes in adult (9-month-old) mice.
Tissue Array-Based Predictions of Pathobiology, Prognosis, and Response to Treatment for Renal Cell Carcinoma Therapy
Authors: John S. Lam, Arie S. Belldegrun, Robert A. Figlin
Journal: Clinical Cancer Research (2004)

Abstract Renal cell carcinoma is the most lethal of the common urologic malignancies, with ∼40% of patients eventually dying of cancer progression. Approximately one third of patients present with metastatic disease, and up to 40% treated for localized disease have a recurrence. Historically, clinical factors have been used as prognostic markers for patients with renal cell carcinoma. Recent advances in the understanding of the pathogenesis, behavior, and molecular biology of renal cell carcinoma have paved the way for developments that may enhance early diagnosis, better predict tumor prognosis, and improve survival for renal cell carcinoma patients. Furthermore, reliable predictive factors are essential for the stratification of patients into clinically meaningful categories, which can be used to provide patients with counseling regarding prognosis, select treatment modalities, and determine eligibility for clinical trials. This has led to the creation of integrated staging systems that predict outcome by combining pathological and clinical variables. Although staging has been improved with the development of integrated systems, molecular tumor markers are expected to revolutionize the staging of renal cell carcinoma in the future. The development of methods based on gene and tissue arrays has created a powerful tool for evaluating hundreds to thousands of tumors simultaneously with histologic, immunohistochemical, and chromosomal analyses. Gene array analysis permits rapid molecular profiling, and tissue arrays enable the analysis of protein expression profiles on specimens to determine their potential clinical significance and role in renal cell carcinoma biology. This article reviews the tissue array-based predictors of pathobiology, prognosis, response to treatment, and potential molecular targets for therapy of renal cell carcinoma.
Acute gastric dilatation in anorexia nervosa.
Authors: G Brook
Journal: BMJ (1977)

reduced to 3 tsg min, and blood sugar two hours later was 8 9 mmoll, and 10 hours later 4 5 mmol 1. Urine tests returned to normal four hours after the reduction and remained normal despite continued high doses of corticosteroids.A later glucose tolerance test while 15 mg day of prednisone was being taken was normai.
Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a “paraptosis”-induced pathway that promotes systemic immunity against intracranial T9 gliomas
Authors: Yijun Chen, Thomas Douglass, Edward W. B. Jeffes, Qingcheng Xu, Christopher C. Williams, Neary Arpajirakul, Christina Delgado, Michael Kleinman, Ramon Sanchez, Qinghong Dan, Ronald C. Kim, H. Terry Wepsic, Martin R. Jadus
Journal: Blood (2002)
Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors
Authors: Olga Sobolev, Patrick Stern, Adam Lacy-Hulbert, Richard O. Hynes
Journal: Cancer Research (2009)

Natural killer (NK) cells recognize and destroy cancer cells through a variety of mechanisms. They may also modulate the adaptive immune response to cancer by interacting with dendritic cells and T cells. Although NK cells play an important role in tumor suppression, little is known about the mechanisms of their recruitment to tumors. Previously it has been shown that subcutaneous tumor growth is enhanced in mice lacking selectins, a family of cell adhesion molecules that mediate the first step of immune cell entry into tissue from the blood. Here we show that NK cell recruitment to tumors is defective in selectin-deficient mice. In vivo NK cell depletion, either pharmacologic or genetic, leads to enhanced subcutaneous tumor growth, similar to the phenotype observed in the selectin-deficient animals. We also show that although NK cells from selectin-deficient mice appear developmentally normal and are functional in in vitro assays, their in vivo function is impaired. This study reveals a role for selectins in NK cell recruitment to tumors and in regulation of effective tumor immunity.
Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial
Authors: Oliver Sartor, Robert Coleman, Sten Nilsson, Daniel Heinrich, Svein I Helle, Joe M O'Sullivan, Sophie D Fosså, Aleš Chodacki, Paweł Wiechno, John Logue, Anders Widmark, Dag Clement Johannessen, Peter Hoskin, Nicholas D James, Arne Solberg, Isabel Syndikus, Nicholas J Vogelzang, C Gillies O'Bryan-Tear, Minghua Shan, Øyvind S Bruland, Christopher Parker
Journal: The Lancet Oncology (2014)
Orai1 Determines Calcium Selectivity of an Endogenous TRPC Heterotetramer Channel
Authors: Donna L. Cioffi, Songwei Wu, Hairu Chen, Mikhail Alexeyev, Claudette M. St. Croix, Bruce R. Pitt, Stefan Uhlig, Troy Stevens
Journal: Circulation Research (2012)

Canonical transient receptor potential 4 (TRPC4) contributes to the molecular composition of a channel encoding for a calcium selective store-operated current, I(SOC), whereas Orai1 critically comprises a channel encoding for the highly selective calcium release activated calcium current, I(CRAC). However, Orai1 may interact with TRPC proteins and influence their activation and permeation characteristics. Endothelium expresses both TRPC4 and Orai1, and it remains unclear as to whether Orai1 interacts with TRPC4 and contributes to calcium permeation through the TPRC4 channel.We tested the hypothesis that Orai1 interacts with TRPC4 and contributes to the channel's selective calcium permeation important for endothelial barrier function.A novel method to purify the endogenous TRPC4 channel and probe for functional interactions was developed, using TRPC4 binding to protein 4.1 as bait. Isolated channel complexes were conjugated to anti-TRPC protein antibodies labeled with cy3-cy5 pairs. Förster Resonance Energy Transfer among labeled subunits revealed the endogenous protein alignment. One TRPC1 and at least 2 TRPC4 subunits constituted the endogenous channel (TRPC1/4). Orai1 interacted with TRPC4. Conditional Orai1 knockdown reduced the probability for TRPC1/4 channel activation and converted it from a calcium-selective to a nonselective channel, an effect that was rescued on Orai1 reexpression. Loss of Orai1 improved endothelial cell barrier function.Orai1 interacts with TRPC4 in the endogenous channel complex, where it controls TRPC1/4 activation and channel permeation characteristics, including calcium selectivity, important for control of endothelial cell barrier function.
Quantitative studies on cutaneous erythema induced by ultraviolet radiation
Authors: P. M. FARR, B. L. DIFFEY
Journal: British Journal of Dermatology (1984)

A reflectance instrument was used to measure the variation in UVR-induced erythema at different positions on the back. The pre-irradiation erythema index decreased from top to bottom of the back but the increase in index remained constant for a fixed exposure dose. In contrast, the minimal erythema dose was higher at lower sites on the back. The measured erythemal response increased linearly with the logarithm of the radiation dose from approximately the minimal erythema dose up to at least fifteen times this value.
Lung function progression in Langerhans cell histiocytosis
Authors: Sophie Krivinskas, Philip Ind, Anthony Chu
Journal: European Respiratory Journal (2012)

LCH is a rare, multisystem dendritic cell disorder commonly involving the lungs. The natural history is variable with little lung function outcome data. In our database of 92 patients referred to AC for treatment, 51 patients were male; mean age at diagnosis was 31 (range 1-77) years (y). 17/92 patients, 10 male, mean age 31 y, had primary lung disease (PLLCH). 14/75 had systemic LCH with lung involvement (SLLCH). All PLLCH had smoked with mean 13 pack-y; 9/17 continued smoking after diagnosis. Initial lung function (n=15) showed mean %predicted FEV 1  76 (34-113)%, VC 81 (53-114)%, TLCO 67 (19-108)%. 2 patients had obstructive, 3 restrictive, and 3 mixed lung disease.  9/14 SLLCH patients were male, mean age 25y, 10 had smoked; mean 12 pack-y, 7 continued smoking after diagnosis. Initial lung function (n=9) showed mean FEV 1  83 (72-105)%pred, VC 89 (72-104)%, TLCO 76 (49-106)%.  In PLLCH (n=14) at mean follow up of 8 (range 1-16) y mean FEV 1  was 70 (30-103)%pred, VC was 84 (51-109)%, TLCO was 63 (17-105)%. Mean change in FEV 1  was -7 (-39 to +12)%, in VC was 1 (-19 to +14)%, in TLCO was -10 (-49 to +29)%. 11/17 patients received treatment. To date 3 have died, 10 are in remission and 4 have active disease.  In SLLCH (n=6) at mean follow up of 6 (2-22) y mean FEV 1  was 83 (66-101)%pred, VC was 92 (79-103)%, TLCO was 93 (82-94)%. Mean change in FEV 1  was -3 (-9 to +5)%, in VC was -1 (-11 to +12)% and in TLCO was 14 (-2 to +45)%. 12/14 patients received treatment. To date 1 has died, 8 are in remission and 5 have active disease.  LCH is rare but in this relatively small, selected series lung function is worse and declines more in patients who present with primary lung involvement than in those with lung involvement in systemic LCH.