Pulmonary Hemorrhage with Diffuse Alveolar Infiltrates in Men with High-Volume Choriocarcinoma
Authors: J O Benditt, H W Farber, J Wright, A B Karnad
Journal: Annals of Internal Medicine (1988)

Brief Reports15 October 1988Pulmonary Hemorrhage with Diffuse Alveolar Infiltrates in Men with High-Volume ChoriocarcinomaJoshua O. Benditt, MD, Harrison W. Farber, MD, Jonathan Wright, MD, Anand B. Karnad, MDJoshua O. Benditt, MDSearch for more papers by this author, Harrison W. Farber, MDSearch for more papers by this author, Jonathan Wright, MDSearch for more papers by this author, Anand B. Karnad, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-8-674 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChoriocarcinoma in men, a rare tumor comprising less than 5% of germ cell tumors, is frequently associated with an elevated serum beta-human chorionic gonadotropin (B-HCG) level. Despite high cure rates reported in men with advanced germ cell tumors of the testis, patients with choriocarcinoma and markedly elevated B-HCG levels (> 50 000 mIU/mL) continue to have a poor prognosis (1-3). Choriocarcinoma is a hemorrhagic tumor, and complications from bleeding at the primary or metastatic site may contribute significantly to the poor prognosis (1, 4).Hemorrhagic complications in women with choriocarcinoma have been well described (5-7); however, similar complications in men...References1. LogothetisSamuelsSelig CMD. Cyclic chemotherapy with cyclophosphamide, doxorubicin and cisplatin plus vinblastine and bleomycin in advanced germinal tumors: results with 100 patients. Am J Med. 1986;81:219-28. CrossrefMedlineGoogle Scholar2. PeckhamOliverBagshawe MRK. Prognostic factors in advanced non-seminomatous germ-cell testicular tumours: results of a multicentre study. Lancet. 1985;1:8-11. MedlineGoogle Scholar3. BoslGellerCirrincione GNC. Multivariate analysis of prognostic variables in patients with metastatic testicular cancer. Cancer Res. 1983;43:3403-7. MedlineGoogle Scholar4. Logothetis C. Choriocarcinoma syndrome. Cancer Bull. 1984;36:118-20. Google Scholar5. NwafoChukudebeluEsegeEgbue DWNM. Haemoptysis as an initial presenting symptom in choriocarcinoma. Afr J Med Sci. 1979;8:109-13. Google Scholar6. WoodMeltzerCarroll TDE. Roentgenogram of the month: hemoptysis and chest mass related to pregnancy. Chest. 1979;75:67-8. CrossrefMedlineGoogle Scholar7. BagshaweGarnett KE. Radiologic changes in the lungs of patients with trophoblastic tumours. Br J Radiol. 1963;36:673-9. CrossrefMedlineGoogle Scholar8. ShermanCiavarraCohen FVM. Testis tumors in negroes. Urology. 1973;2:318-20. CrossrefMedlineGoogle Scholar9. WilliamsBirchEinhornIrwinGrecoLoehrer SRLLFP. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med. 1987;316:1435-40. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Boston University School of Medicine and Boston City Hospital, Boston, Massachusetts. For current author addresses, see end of text. 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