tbuckley/cabot-search huggingface dataset:
Total Pancreatectomy With Islet Autotransplantation Improves Quality of Life in Patients With Refractory Recurrent Acute Pancreatitis
Authors: Melena D Bellin, Tossapol Kerdsirichairat, Gregory J Beilman, Ty B Dunn, Srinath Chinnakotla, Timothy L Pruett, David R Radosevich, Sarah J Schwarzenberg, David E R Sutherland, Mustafa A Arain, Martin L Freeman
Journal: Clinical Gastroenterology and Hepatology (2016)
The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children
Authors: C.I. Vardavas, C. Hohmann, E. Patelarou, D. Martinez, A.J. Henderson, R. Granell, J. Sunyer, M. Torrent, M.P. Fantini, D. Gori, I. Annesi-Maesano, R. Slama, L. Duijts, J.C. de Jongste, J.J. Aurrekoetxea, M. Basterrechea, E. Morales, F. Ballester, M. Murcia, C. Thijs, M. Mommers, C.E. Kuehni, E.A. Gaillard, C. Tischer, J. Heinrich, C. Pizzi, D. Zugna, U. Gehring, A. Wijga, L. Chatzi, M. Vassilaki, A. Bergström, E. Eller, S. Lau, T. Keil, M. Nieuwenhuijsen, M. Kogevinas
Journal: European Respiratory Journal (2016)

Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged ≤2 years. Individual data of 27 993 mother–child pairs from 15 European birth cohorts were combined in pooled analyses taking into consideration potential confounders. Children with maternal exposure to passive smoking during pregnancy and no other smoking exposure were more likely to develop wheeze up to the age of 2 years (OR 1.11, 95% CI 1.03–1.20) compared with unexposed children. Risk of wheeze was further increased by children's postnatal passive smoke exposure in addition to their mothers' passive exposure during pregnancy (OR 1.29, 95% CI 1.19–1.40) and highest in children with both sources of passive exposure and mothers who smoked actively during pregnancy (OR 1.73, 95% CI 1.59–1.88). Risk of wheeze associated with tobacco smoke exposure was higher in children with an allergic versus nonallergic family history. Maternal passive smoking exposure during pregnancy is an independent risk factor for wheeze in children up to the age of 2 years. Pregnant females should avoid active and passive exposure to tobacco smoke for the benefit of their children's health.
Corrections to “A comparison of the results of renal transplantation from non-heat-beating, conventional cadaveric, and living donors. Kidney Int 58:2585–2591, 2000”
Authors: Michael L. Nicholson, Matthew S. Metcalfe, Steven A. White, Julian R. Waller, Tahir M. Doughman, Terry Horsburgh, John Feehally, Susan J. Carr, Peter S. Veitch
Journal: Kidney International (2001)
Metabolic syndrome in castration-resistant prostate cancer patients treated with abiraterone.
Authors: Vincenza Conteduca, Orazio Caffo, Lisa Derosa, Antonello Veccia, Elisabetta Petracci, Vincenzo Emanuele Chiuri, Matteo Santoni, Daniele Santini, Lucia Fratino, Francesca Maines, Sara Testoni, Ugo De Giorgi
Journal: Journal of Clinical Oncology (2015)

213 Background: The presence and the impact of metabolic syndrome (MS) in castration-resistant prostate cancer (CRPC) men treated with novel hormonal therapies, as abiraterone, has not still been studied. The study aims to assess the impact of MS on progression free survival (PFS) and overall survival (OS) from time starting abiraterone. Methods: We retrospectively evaluated a consecutive series of metastatic CRPC patients treated with abiraterone after docetaxel failure. MS, as defined by modified Adult Treatment Panel (ATP) III criteria, was assessed at the time of initiation of abiraterone, during treatment and follow-up. Cox regression model was used to evaluate the role of MS on the two end-points. Results: One hundred seventy eight patients had sufficient data to assess the presence of MS. Mean age (± SD) at start of abiraterone was 74.0 ± 7.7 years. Seventy out of 178 patients (39.5%) met MS criteria at baseline, before abiraterone initiation, whereas for eleven patients this occurred during treatment. Median PFS was equal to 5 months for patients with MS versus 9 months for those without MS. Patients with MS had a 2-fold increased risk of progression or death for all causes than patients without MS (HR=1.9, 95% CI [1.3-2.7], P&lt;0.001). Median OS was 16 months and 22 months in patients with and without MS, respectively. After adjusting for covariates, MS resulted not significantly associated to OS (HR=1.2, 95% CI [0.8-1.9], P=0.340). Conclusions: MS may represent a complication of patients treated with abiraterone. The presence of MS appears to be a risk factor for shorter PFS in patients with CRPC treated with abiraterone, even if it does not show any impact on OS, so it needs a further prospective evaluation.
Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting
Authors: Kyungim Kim, Keun Sang Oh, Dal Yong Park, Jae Young Lee, Beom Suk Lee, In San Kim, Kwangmeyung Kim, Ick Chan Kwon, Yoon Kim Sang, Soon Hong Yuk
Journal: Journal of Controlled Release (2016)
DOCK8: regulator of Treg in response to corticotropin-releasing hormone
Authors: S. Jin, J. U. Shin, J. Y. Noh, H. Kim, J. Y. Kim, S. H. Kim, J. H. Kim, C. O. Park, N. Lee, H. Lee, J. S. Lee, K. H. Lee
Journal: Allergy (2016)

Atopic dermatitis (AD) is exacerbated by psychological factors, such as stress. We previously reported that corticotrophin-releasing hormone (CRH) treatment in AD patients decreased the proportion of IL-10(+) Tr1 cells, a subset of inducible regulatory T cells (Tregs). However, changes in the function of Tregs in response to CRH have yet to be studied.We analyzed the total proteins taken from CRH-treated and untreated Tregs from AD mice model (NC/Nga mice) using a quantitative proteomic analysis for the different protein expressions.We found a statistically decreased protein level of DOCK8 in CRH-treated Tregs from AD mice. In human, DOCK8 protein levels were also significantly decreased in CRH-treated Tregs from AD patients. Moreover, the expression of DOCK8 in Tregs was inversely correlated with the anxiety levels in the AD patients. In addition to the clinical correlation of DOCK8 with the stress level of AD patients, the knockdown of DOCK8 in Tregs reduced the inhibitory cytokines, IL-10 and TGF-β, and inhibited the regulatory function of Tregs to suppress the proliferation and TNF-α release of CD4(+) T cells in vitro.This study provides new insights on the mechanisms of stress-induced AD aggravation by showing that CRH downregulated DOCK8 expression in Tregs that not only clinically correlates with anxiety levels of AD patients but also regulates suppressive function of Tregs on CD4(+) T cells.
Age and axillary lymph node ratio in postmenopausal women with T1-T2 node positive breast cancer.
Authors: B. H. Ly, V. Vinh-Hung, S. A. Joseph, N. Coutty, G. Vlastos, N. P. Nguyen
Journal: Journal of Clinical Oncology (2010)

e11004 Background: To examine the relationship between age and lymph node ratio (LNR, number of positive nodes divided by number of examined nodes), and to determine their effects on breast cancer mortality. Methods: A total of 38,146 cases of women aged 50+ years, diagnosed in 1988-1997 (cohort 1) and 1998-2006 (cohort 2) with a unilateral histologically confirmed T1-T2 node positive surgically treated primary breast carcinoma, without distant metastases, were selected from the Surveillance, Epidemiology, and End Results (SEER). Correlations were computed by linear regression. Survival primary end-point was breast cancer specific survival (BCSS). Effects of age (elderly 70+, vs. 50-69 years) and LNR (high > 0.25, vs. < = 0.25) were adjusted in Cox models for registry area, marital status, race, histological grade, hormone receptor status, tumor size, numbers of nodes, and local therapies. Results: In both cohorts, LNR correlated with age, increasing from 0.26 in patients 50 years old, to 0.29 in patients 70+ years (p < 0.0001). In multivariate analysis, high age and high LNR were associated with increased risks of breast cancer mortality, with hazard ratio for age 1.10 (95%CI 1.04–1.17) and LNR 1.53 (1.40–1.68) (cohort 1), 1.61 (1.46–1.78) and 1.65 (1.43–1.90) (cohort 2). BCSS at 10-years in elderly women with high LNR was 52.3%, as compared to 57.5% in younger women (p = 0.0003) (cohort 1). Conclusions: Older age at diagnosis correlated with higher LNR. Elderly women with a higher tumor burden indicated by higher LNR had a significant increased risk of breast cancer death as compared with younger post-menopausal women. No significant financial relationships to disclose.
For Direct Words on Abortion
Authors: P Ramsey
Journal: New England Journal of Medicine (1971)

To the Editor: Dr. Bernard D. Daviss editorial contained seriously unscientific statements about  recent article of mine in the Journal.  I characterized the earliest conceptus as having surprising uniqueness and individuality but in that article said nothing about its sactity.  I certainly expressed no a priori metaphysical conviction about the sanctity of unborn infants.  Since I advanced no view on abortion I could not have presented as charged a conservative view.  My plea was that we should eschew all the current euphemisms behind which hides bad moral reasoning about abortion.  I suggested killing the fetus in order to terminate pregnancy as an exact description of what is done.  If Dr. Davis had taken that to mean an insistance that we identify abortion with  he would have been correct since the latter is only  briefer way of making the former descriptive statement.  To say however that I insisted that we identify abortion with  is simply false.  Anyway if homicide is sometimes justifiable so also  fortiori feticide may be.  Those paragraphs in my article were entirely directed against the continued use of such terms as interrupting pregnancy an expression that incidentally was first used by physicians when they were discussing the indications for  new  procedure that saved both the mother and the child: cesarean section.  Who knows what  priori methaphysical convictions about the wastage of unborn infants or about their sancity may lurk behind our euphemisms as long as we are unable even to speak directly of fetal life?(FULL TEXT)
Follow-up of pulmonary right-to-left shunt in hereditary haemorrhagic telangiectasia
Authors: Veronique M.M. Vorselaars, Sebastiaan Velthuis, Repke J. Snijder, Cornelis J.J. Westermann, Jan A. Vos, Johannes J. Mager, Martijn C. Post
Journal: European Respiratory Journal (2016)

Pulmonary arteriovenous malformations (PAVMs) are associated with severe neurological complications in hereditary haemorrhagic telangiectasia (HHT). Transthoracic contrast echocardiography (TTCE) is recommended for screening of pulmonary right-to-left shunts (RLS). Although growth of PAVMs is shown in two small studies, no studies on follow-up with TTCE exist.All HHT patients underwent a second TTCE 5 years after initial screening. Patients with a history of PAVM embolisation were excluded. Pulmonary RLS grade on TTCE after 5 years was compared to the grade at screening.200 patients (53.5% female, mean±sd age at screening 44.7±14.1 years) were included. Increase in RLS grade occurred in 36 (18%) patients, of whom six (17%) underwent embolisation. The change in grade between screening and follow-up was not more than one grade. Of patients with nontreatable pulmonary RLS at screening (n=113), 14 (12.4%) underwent embolisation. In patients without pulmonary RLS at initial screening (n=87), no treatable PAVMs developed during follow-up.Within 5 years, no treatable PAVMs developed in HHT patients without pulmonary RLS at initial screening. Increase in pulmonary RLS grade occurred in 18% of patients, and never increased by more than one grade. Of patients with nontreatable pulmonary RLS at initial screening, 12% underwent embolisation.
Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes
Authors: Sheng Zhou, Soghra Fatima, Zhijun Ma, Yong-Dong Wang, Taihe Lu, Laura J Janke, Yang Du, Brian P Sorrentino
Journal: Molecular Therapy (2016)

Insertional oncogenesis due to retroviral (RV) vector integration has caused recurrent leukemia in multiple gene therapy trials, predominantly due to vector integration effects at the LMO2 locus. While currently available preclinical safety models have been used for evaluating vector safety, none have predicted or reproduced the recurrent LMO2 integrations seen in previous X-linked severe combined immunodeficiency (X-SCID) and Wiskott–Aldrich clinical gene therapy trials. We now describe a new assay for assessing vector safety that recapitulates naturally occurring insertions into Lmo2 and other T-cell proto-oncogenes leading to a preleukemic developmental arrest in primary murine thymocytes cultured in vitro. This assay was used to compare the relative oncogenic potential of a variety of gamma-RV and lentiviral vectors and to assess the risk conferred by various transcriptional elements contained in these genomes. Gamma-RV vectors that contained full viral long-terminal repeats were most prone to causing double negative 2 (DN2) arrest and led to repeated cases of Lmo2 pathway activation, while lentiviral vectors containing these same elements were significantly less prone to activate proto-oncogenes or cause DN2 arrest. This work provides a new preclinical assay that is especially relevant for assessing safety in SCID disorders and provides a new tool for designing safer RV vectors. Insertional oncogenesis due to retroviral (RV) vector integration has caused recurrent leukemia in multiple gene therapy trials, predominantly due to vector integration effects at the LMO2 locus. While currently available preclinical safety models have been used for evaluating vector safety, none have predicted or reproduced the recurrent LMO2 integrations seen in previous X-linked severe combined immunodeficiency (X-SCID) and Wiskott–Aldrich clinical gene therapy trials. We now describe a new assay for assessing vector safety that recapitulates naturally occurring insertions into Lmo2 and other T-cell proto-oncogenes leading to a preleukemic developmental arrest in primary murine thymocytes cultured in vitro. This assay was used to compare the relative oncogenic potential of a variety of gamma-RV and lentiviral vectors and to assess the risk conferred by various transcriptional elements contained in these genomes. Gamma-RV vectors that contained full viral long-terminal repeats were most prone to causing double negative 2 (DN2) arrest and led to repeated cases of Lmo2 pathway activation, while lentiviral vectors containing these same elements were significantly less prone to activate proto-oncogenes or cause DN2 arrest. This work provides a new preclinical assay that is especially relevant for assessing safety in SCID disorders and provides a new tool for designing safer RV vectors.
Human basophil chemotaxis and activation are regulated via the histamine H4 receptor
Authors: S. Mommert, S. Kleiner, M. Gehring, B. Eiz‐Vesper, H. Stark, R. Gutzmer, T. Werfel, U. Raap
Journal: Allergy (2016)

IgE-mediated cross-linking of FcεRI results in the release of mediators stored in basophil granules, such as histamine and proteases, and in the de novo synthesis of sulfidoleukotrienes.In this study, we investigated the role of the histamine receptors, in particular that of the histamine H4 receptor (H4R), in modulating human basophil function.The mRNA expression of the histamine receptors was measured by real-time PCR. Migration of basophils was assessed using the modified Boyden chamber technique. The expression levels of CD63 and CD203c on the cell surface and the sulfidoleukotriene release were determined by flow cytometry and ELISA, respectively.We could show that highly purified basophils express the H1R, H2R, and H4R but not the H3R mRNA. Human basophils expressed higher H4R mRNA levels as compared to the expression levels of the H1R (P < 0.01). Histamine and the H4R agonist ST-1006 initiated active migration of basophils (P < 0.001). A significant reduction in FcεRI cross-linking-mediated surface expression of CD63 and CD203c was observed on basophils after pre-incubation with histamine or the specific H4R agonist ST-1006 (P < 0.01). The synthesis and release of sulfidoleukotrienes from basophils after activation with different stimuli, by FcεRI cross-linking or by stimulation with hymenoptera venom allergens, were significantly reduced by histamine or the H4R agonist ST-1006 (P < 0.05-0.001).These data imply that the H4R regulates IgE-dependent processes in human basophils and provides a novel function of the H4R preventing an overwhelming immune reaction by engagement of a negative feedback loop.
Abstract 52: Temporal Regulation Of Cardiac Cytokine Expression in Response to Chronic β-Adrenergic Receptor Stimulation
Authors: Laurel A Grisanti, Ashley A Repas, Rhonda L Carter, Jennifer A Talarico, Jessica L Gold, Walter J Koch, Douglas G Tilley
Journal: Circulation Research (2014)

Chronic catecholamine stimulation of β-adrenergic receptors (βAR) is ultimately deleterious during heart failure (HF). While alterations in cytokines contribute to HF pathogenesis and βAR have been demonstrated to regulate cytokines in different models of HF, a comprehensive understanding of this relationship is lacking. Thus, we sought to characterize the impact of chronic βAR signaling on cardiac cytokine expression in vivo. C57BL/6 mice underwent infusion with vehicle or isoproterenol (Iso; 3 mg/kg/day) via minipumps for 1 or 2 weeks and cardiac function was monitored via echocardiography. At study termination, hearts were excised and assessed for changes in hypertrophy, fibrosis and apoptosis, each of which were enhanced by Iso. Expression of cardiac transcripts were assessed via whole transcriptome analysis, where 780 and 689 transcripts were significantly altered at 1 and 2 weeks of Iso, respectively, with only 115 transcripts regulated similarly between the two cohorts. Significant changes in cytokine transcript expression was observed in response to chronic Iso and Ingenuity Pathway Analysis (IPA) predicted the involvement of additional upstream cytokine regulators potentially regulated by Iso. Transcriptome results and IPA predictions were confirmed via qRT-PCR. A cytokine array also confirmed temporally-distinct alterations in the expression of 42 cytokines at the protein level. Differential alterations in cytokine expression resulting from 1 versus 2 weeks of Iso infusion suggest that cytokine-directed therapies may have distinct temporally-dependent consequences on cardiac function and survival under conditions of chronic catecholamine stress.
Masking and Gowning in Nurseries for the Newborn Infant
Authors: J. O. Forfar, A. F. Maccabe
Journal: BMJ (1958)

An investigation amongst full-time newborn babies in two nurseries has been carried out in an attempt to discover the tsLual routes of spread of Stapli.aur(eius.Initially 53 babies were all found to be nasal carriers by the 10th day, and 11 out of 12 of these babies also carried staphylococci in their stools.Examination of bedding suggested that this was not the immediate source of staphylococci, and prevention of possible contamina- tion from the staff by the use of chlorhexidine hand- cream or gowns made little difference.The use of triple dye to the umbilicus and individual gowns for each baby, both as separate and as combined measures, prodluced a reduction in the nasal carriage rate on the 12th day of life by about 25-30%.No evidence was obtained that babies gained staphylococci from their mothers, but there was evidence that staphylococci on the mothers' breasts came from their babies.We wouild like to thlank Dr. C. F. Harris and Mr. J. Beattie for permission to conduct these trials; we are also muclh indebted to the Sister in Charge of the
Abstract 9927: Helix B Surface Peptide, a Small Non-erythropoietic Molecule Based on the Erythropoietin Structure, Effectively Ameliorates the Progression of Chronic Heart Failure in the Rat Post Myocardial Infarction Model
Authors: Ismayil Ahmet, Hyun-Jin Tae, Michael Brines, Anthony Cerami, Edward G Lakatta, Mark Talan
Journal: Circulation (2012)

The cardioprotective properties of Erythropoietin (EPO) are well documented in pre-clinical studies. However, due to its erythropoietic and prothrombotic properties, the EPO treatment cannot be used in chronic heart failure (CHF), unless indicated by accompanied anemia. Helix B surface peptide (HBSP), a small peptide synthetized on the basis of EPO molecule (ARA290, Araim Pharmaceutical), does not stimulate erythropoiesis. We have reported similarly strong cardioprotective effects of HBSP and EPO in the rat model of myocardial infarction (MI). In this study, we tested the effect of long-term treatment with HBSP on mortality and cardiac remodeling in post-MI CHF in rats. For the 10 months, starting two weeks after left coronary artery ligation, rats received the i.p. injections of HBSP (60µg/kg; n=33) or saline (n=33) 2 times per week. Compared to saline-treated rats, HBSP treatment significantly reduced mortality (35% vs. 65%; p&lt;0.05). Repeated Echocardiography demonstrated remarkable attenuation of left ventricular (LV) chamber dilatation (EDV: 41% vs. 86%; ESV: 44% vs. 135%; p&lt;0.05), LV functional deterioration (EF: -4% vs. -63%; p&lt;0.05) and MI expansion (3% vs. 38%; p&lt;0.05) in HPSP-treated rats compared to saline-treated rats. Blood hematocrit level measured monthly was not affected by HBSP treatment. An invasive hemodynamic assessment at the end of 10-mo treatment showed better LV systolic function (PRSW: 63±5 vs. 40±4; p&lt;0.05) and Arterio-ventricular coupling (Ea/Ees: 1.2±0.2 vs. 2.7±0.7; p&lt;0.05) in HBSP-treated rats compared to saline-treated rats. Histological analysis revealed less apoptosis (0.6±0.1% vs. 0.9±0.1%; p&lt;0.05), myocardial fibrosis (2.6±0.2% vs. 4.1±0.5%; p&lt;0.05), and myocyte hypertrophy (cell diameter: 31±1µm vs. 37±1µm; p&lt;0.05) in non-infarcted myocardium among HBSP-treated rats compared to saline-treated rats. Results suggest that HBSP could be considered as a safe alternative to EPO for a further clinical testing in the patients with chronic heart failure.
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
Authors: Ximena Bonilla, Laurent Parmentier, Bryan King, Fedor Bezrukov, Gürkan Kaya, Vincent Zoete, Vladimir B Seplyarskiy, Hayley J Sharpe, Thomas McKee, Audrey Letourneau, Pascale G Ribaux, Konstantin Popadin, Nicole Basset-Seguin, Rouaa Ben Chaabene, Federico A Santoni, Maria A Andrianova, Michel Guipponi, Marco Garieri, Carole Verdan, Kerstin Grosdemange, Olga Sumara, Martin Eilers, Iannis Aifantis, Olivier Michielin, Frederic J de Sauvage, Stylianos E Antonarakis, Sergey I Nikolaev
Journal: Nature Genetics (2016)
Vitamin D3 therapy in patients with asthma complicated by sinonasal disease: Secondary analysis of the Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma trial
Authors: Junfang Jiao, Tonya S. King, Matthew McKenzie, Leonard B. Bacharier, Anne E. Dixon, Christopher D. Codispoti, Ryan M. Dunn, Nicole L. Grossman, Njira L. Lugogo, Sima K. Ramratnam, Russell S. Traister, Michael E. Wechsler, Mario Castro
Journal: Journal of Allergy and Clinical Immunology (2016)