tbuckley/cabot-search huggingface dataset:
Prognostic importance of objective response (OR) to chemotherapy for time to progression (TTP) and survival time (ST) in advanced non-small cell lung cancer (NSCLC): Analysis of individual patient data from platinum-based clinical trials in monocentric setting
Authors: D. Z. Radosavljevic, S. Jelic, Z. Tomasevic, I. Kezic
Journal: Journal of Clinical Oncology (2005)

7238 Background: Despite some reports about the relationship between OR and ST in advanced NSCLC there is still no evidence about the causality of this relation. Of importance is to know if the OR add any prognostic information to other known prognostic factors for survival. Landmark method helps to avoid time-bias in disease where not only OR represents a short-term outcome. Methods: Individual data from 362 patients (pts) from four phase II/III clinical trials were reviewed: all pts were treated with cisplatin (120mg/m2) or carboplatin (400mg/2 and thereafter AUC 5)-based doublets or triplets, from 1990 to 2004. Cycles were repeated every 4 weeks, response to therapy was evaluated according to WHO criteria. M/F ratio was 318/44, older than 65 were 59/362 pts, stage IIIb/IV had 165/197 pts, initial PS 0/1/2/3 was recorded in 31/187/113/31 pts respectively, median of cycles received was 4. CR was achieved in 9 pts, PR in 108 pts (RR in 117 pts-32%), SD in 167 pts (46%) and PD in 79 pts (22%). Median TTP was 5 months and median ST was 7 months. Landmark method was performed at the 4 months point. Results: Univariate survival analysis, performed on landmark-adjusted TTP showed no significant differences between response categories (RR vs SD): log rank test, p=0.296 (median TTP in RR was 4 months: CI 95% [4,6] vs 3 months: CI 95% [3,4] in SD), while the same analysis on landmark-adjusted ST revealed statistically significant difference among response categories: log rank test, p=0.005 (median ST in RR was 7 months: 95%CI [6,9], SD 5 months: 95%CI[4,6], PD 3 months: 95%CI[2,5]). Of interest is the finding that in stage IIIb OR confirmed its prognostic value for increased ST (p=0.003), while in stage IV log rank test failed to reveal the same (p=0.419). Conclusions: Preliminary results are in accordance with reports favoring OR in advanced NSCLC as prognostic factor for increased ST. It seems that there is not a relationship between OR and TTP. No significant financial relationships to disclose.
Acquired Multidrug-Resistant Tuberculosis--Buenaventura, Colombia, 1998
Journal: JAMA (1998)

The incidence of tuberculosis in Buenaventura Colombia in 1996 was 90.5/100000 compared with 26.5/100000 in Colombia as a whole.  In 1997 at the request of the Secretary of Health the International Center for Training and Medical Investigation in Cali performed sputum cultures for Mycobacterium tuberculosis and drug susceptibility testing on isolates from 18 of 24 tuberculosis patients from Buenaventura known to be clinically unresponsive to standard treatment.  Multidrug-resistant tuberculosis was detected in 12 (67%) patients 4 of whom subsequently died.  The Centers for Disease Control and Prevention was requested to investigate these cases further.  The 12 patients had received a median of 3.5 years of tuberculosis treatment; however treatment was interrupted and reinstated several times in 11 patients.  10 patients had a history of not taking the prescribed antitubercular medications for at least 1 month.  11 patients had medications improperly added or subtracted from their treatment regimen.  3 of the 10 patients with available data did not have sputum specimens obtained after failing to present for treatment for at least 1 month and 6 of 9 cases with available data did not receive directly observed therapy.  Overall the 12 cases experienced a median of 3.9 instances of incorrect treatment or management of their illness.  These findings have led to improvements in tuberculosis control efforts in Buenaventura including the installation of mechanisms to monitor and evaluate tuberculosis services training for physicians and health care workers in the management of multidrug-resistant tuberculosis and development of individualized treatment regimens for each patient based on drug susceptibility testing.
Effect of various Neurally adjusted ventilatory assist (NAVA) gains on the relationship between diaphragmatic activity (Eadi max) and tidal volume
Authors: YS Chiew, L. Piquilloud, Thomas Desaive, Bernard Lambermont, J Roeseler, JP Revelly, E. Bialais, D. Tassaux, P Jolliet, JG Chase
Journal: Intensive Care Medicine (2010)
Phase I Study of Preoperative Oral Uracil and Tegafur Plus Leucovorin and Radiation Therapy in Rectal Cancer
Authors: Paulo M. Hoff, Nora Janjan, Everardo D. Saad, John Skibber, Christopher Crane, Yvonne Lassere, Karen R. Cleary, Steve Benner, Jacqueline Randolph, James L. Abbruzzese, Richard Pazdur
Journal: Journal of Clinical Oncology (2000)

PURPOSE: Preoperative combined-modality therapy for rectal cancermay allow for sphincter preservation, while decreasing recurrencerates and improving the overall prognosis. Oral chemotherapy withuracil and tegafur (UFT) plus leucovorin (LV) may reduce costs andcomplications associated with protracted infusions offluorouracil. Our goal was to evaluate the safety of UFT plus LVcombined with preoperative radiation and determine themaximum-tolerated dose (MTD) and dose-limiting toxicity (DLT) of UFTplus LV in this setting. PATIENTS AND METHODS: Patients with tumor-node-metastasis stage II or III rectalcancer received escalating doses of UFT (starting at 250mg/m 2 /d, with50-mg/m 2 /d increments between consecutivecohorts) and fixed doses of LV (90 mg/d). The UFT and LV combinationwas given 5 days per week concurrently with a 5-week course ofpreoperative radiation totaling 45 Gy (1.8 Gy/fraction). Surgery wasperformed 4 to 6 weeks after radiation and was followed by four 35-daycycles of fixed doses of UFT and LV (28 days of therapy eachcycle). RESULTS: Fifteen patients weretreated, and 13 received the full preoperative chemotherapy. Allplanned radiation was delivered successfully. The MTD of UFT withradiation was 350 mg/m 2 /d with 90 mg/d ofLV. Diarrhea was the DLT. Sphincter-preserving surgery was performedin 12 of 14 patients. One patient had progressive disease beforesurgery. Pathologic evaluation of 14 resected specimens showed acomplete response in three cases. CONCLUSION: Preoperative chemoradiation with oral UFT plus LV isfeasible and well tolerated and should be furtherinvestigated.
Abstract 12436: Worsening of Renal Function after One Year, Not During Hospitalization, is Stronger Predictor of Prognosis in Patients With ADHF
Authors: Tomoya Ueda, Rika Kawakami, Yu Sugawara, Takaki Matsumoto, Sadanori Okada, Tsunenari Soeda, Satoshi Okayama, Satoshi Somekawa, Yukiji Takeda, Makoto Watanabe, Hiroyuki Kawata, Shiro Uemura, Yoshihiko Saito
Journal: Circulation (2013)

Background: Renal dysfunction is one of the strongest risk factors for prognosis of acute decompensated heart failure (ADHF). In the real world, however, renal function is labile during the management of ADHF. Although the analyses using the baseline serum creatinine level (SCr) or worsening of SCr during hospitalization have been reported, significance of worsening of renal function (WRF) after discharge is not investigated well. Method: In this context, 459 consecutive patients with ADHF emergently admitted to our hospital, we measured SCr at three points (on admission, at discharge and a year after discharge) in 192 patients. The patients were divided into 2 groups according to WRF, defined as an increase in SCr >0.3 mg/dl after one year from discharge. Kaplan-Meier survival analysis and Cox regression analysis with a proportional hazard model were performed to assess outcomes. Result: During a mean follow-up of 37.1 months, there were 61 deaths from all causes, including 37 deaths from cardiovascular ...
Acute side effects of intraoperative electron radiotherapy of breast cancer.
Authors: Edwin Boelke, Wilfried Budach, Wolfgang Janni, Karin Zwiefel, Freddy-Joel Njanang, Ioannis Simiantonakis, Christiane Matuschek
Journal: Journal of Clinical Oncology (2012)

112 Background: Intraoperative boost irradiation as part of breast-conserving therapy is a perfect method to adequately capture the high risk tumor relapse area. The most homogeneous dose distribution is achieved with electrons. Intraoperative radiotherapy (IOERT) as a boost for breast cancer releases a high single dose of radiation to the breast tissue; therefore acute toxicity is of particular attention. To date there is only inadequate information available on breast cancer patients treated with IORT using electrons applied as a boost. We therefore analyzed the acute toxicity after radiotherapy with 10 Gy as a boost with a minimum follow-up of 3 months. Methods: A total of 69 patients treated with IOERT (10Gy with 5, 7 and 9 MeV electrons) with a dedicated robotic linac (NOVAC 7, New Radiant Technology, Aprilia, Italy) to the tumor bed during breast-conserving surgery as a boost followed by whole-breast radiotherapy (WBRT, 50.4 Gy; 1.8 Gy per fraction) were included in this study. All patients underwent a retrospective follow-up (median, 8 months; range 1-17 months) regarding acute side effects within the first three months. Toxicities were documented using the common toxicity criteria (CTC 4.0 of the European Organization for Research and Treatment of Cancer). Results: The IOERT was well tolerated. As a side effect there was one patient with seroma. Two patients developed chronic pain in the irradiated breast. Two patients developed a secondary wound healing. The remaining patients did not develop any grade 3 or 4 side effects. The observed toxicity rates were not influenced by age, tubus size, electron energy or systemic therapy. Conclusions: After IOERT of the breast using electrons we did not find any unexpected acute toxicity rates.
A phase I clinical and pharmacokinetic study of escalating doses of fixed rate and escalating infusion duration of gemcitabine given via an intrahepatic pump for patients with hepatic metastases
Authors: A. N. Tse, G. Raggio, M. Morse, N. E. Kemeny
Journal: Journal of Clinical Oncology (2006)

14035 Background: Gemcitabine (Gem) is an attractive chemotherapeutic agent for hepatic arterial infusion (HAI) because of its broad-spectrum anti-tumor activity, high systemic clearance, and possibly high hepatic extraction. Pre-clinical models indicate that cytotoxicity of gemcitabine increases with duration of drug exposure. Methods: In this phase I trial, successive cohorts of patients (Pts) with hepatic metastases of colorectal or bile duct cancer were given HAI Gem 3 out of 4 weeks. During the dose escalation phase, increasing doses of HAI Gem (800, 1000, 1200 and 1500 mg/m 2 ) were given at 10 mg/m 2 /min. During the infusion duration escalation phase, 1000 mg/m 2 of HAI Gem was given over increasing duration of infusion (200, 300, and 400 min.). To compare the pharmacokinetics of HAI Gem with that of intravenous (iv) Gem, Pts enrolled to the infusion duration escalation phase received a 60-min. infusion of iv Gem during the first treatment week at the same dose-rate as with subsequent HAI Gem. Results: To date, 23 Pts have been enrolled and 22 were evaluable for toxicity (median age 64; median KPS 90%; 13 males/9 females). All Pts had prior HAI FUDR treatment. HAI Gem is well tolerated up to 1500 mg/m 2 given at 10 mg/m 2 /min and up to 1000 mg/m 2 infused over 300 min. Only one Pt had to discontinue therapy due to toxicity (grade 4 alkaline phosphatase) and one DLT was observed (grade 3 rash). Most common grade 2+ toxicities include neutropenia (40%), thrombocytopenia (23%), bilirubin (14%), and alkaline phosphatase (23%). The steady-state level of Gem when given by HAI was lower than that obtained when the drug was given by iv in 3 out of 4 Pts (0.62 vs 1.8; 0.38 vs 2.9; 0.36 vs 0.63 mcg/ml). One Pt with cholangiocarcinoma had a partial response and one Pt had stable disease for 5 months. Conclusions: HAI Gem is safe and can be given as prolonged infusion not achievable with systemic administration. Pharmacokinetic studies indicate good hepatic extraction of the drug. The MTD has not been reached. [Table: see text]
Use of novel optical proteomics to profile breast cancer patients leading to individualised prognosis and tailored treatment
Authors: M. T. Kelleher, F. Festy, P. R. Barber, C. Gillett, E. Ofo, A. Coolen, S. Pinder, G. Patel, B. Vojnovic, T. Ng, P. A. Ellis
Journal: Journal of Clinical Oncology (2009)

e22090 Background: Optical proteomics quantifies interactions between proteins and post-translational modifications by measuring Förster resonance energy transfer (FRET) quantified by fluorescence lifetime imaging microscopy (FLIM). This project aims to derive multiple high throughput optical proteomic markers, to predict metastatic risk at first diagnosis, and to perturb ‘high risk' protein-protein interactions using targeted therapeutics. This initial step develops robust FRET/FLIM assays, suitable for use in formalin fixed paraffin embedded (FFPE) tissue to be correlated with patient outcome. Methods: Fluorophore-conjugated antibodies to proteins involved in cell migration and survival, were applied to tissue microarrays (TMA), created from archived FFPE invasive ductal breast carcinoma samples. Where fluorophores are located within nanometer proximity, FRET occurs, thus allowing quantification of protein-protein interaction. Ezrin and PKCα phosphorylation, distribution, and interaction were imaged on four TMAs (patients diagnosed with early breast cancer 1984 -1987: 20 years follow-up data). Results: 71 patient samples were optically imaged. Patients were clustered based on the pairwise distances between 18 optical variables ‘input data'. Data are represented on self organising maps and dendrograms and correlated with clinical outcome ‘output data', displaying a heatmap distribution. Conclusions: Ezrin and PKCα phosphorylation, distribution, and interaction imaged optically within FFPE contain prognostic information regarding metastatic outcome in breast cancer, thus stepping ever closer to individualising prognosis. These advanced optics-based parameters informing on metastatic potential will be validated in prospective studies in conjunction with FRET/FLIM assays measuring HER2/HER3 dimerisation, and EGFR and HER2 ubiquitination in order to improve patient selection for targeted therapy. No significant financial relationships to disclose.
Comparison of clinical efficacy between HLA-mismatched related and HLA-matched unrelated donor hematopoietic stem cell transplantation for hematopoietic malignancies
Authors: Sijian Yu, Zhiping Fan, Dan Xu, Fen Huang, Yu Zhang, Yongqiang Wei, Hongsheng Zhou, Qianli Jiang, Min Dai, Na Xu, Jing Sun, Qifa Liu, MD
Journal: Blood (2013)
Advances in cardiology, vol 25 Edited by J T August, M W Anders, and F Murad. (Pp 464; $110.) San Diego: Academic Press, 1994. ISBN 0-12-032925-5
Authors: K Banner
Journal: Cardiovascular Research (1995)

Journal Article Advances in cardiology, vol 25: Edited by J T August, M W Anders, and F Murad. (Pp 464; $110.) San Diego: Academic Press, 1994. ISBN 0-12-032925-5 Get access KH Banner KH Banner London, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 4, April 1995, Page 584, https://doi.org/10.1016/S0008-6363(95)90128-0 Published: 01 April 1995
Invasive respiratory Aspergillosis is a treatable disease with early diagnosis and aggressive therapy
Authors: F. B. Cakir, E. Cakir, S. G. Berrak, Z. S. Uyan, D. B. Beker, F. Karakoc, C. Canpolat, E. Dagli
Journal: Journal of Clinical Oncology (2007)

19632 Background: Invasive respiratory aspergillosis (IRA) is a fulminant infection in immunocompromised hosts. This study aims to evaluate the effectiveness of early screening of patients and the outcome of them during febrile neutropenia (FNP) episodes. Methods: Between 2003 and 2006, 212 FNP episodes were evaluated and the cases who are still febrile at their fifth FNP treatment were screened with computerized tomography (CT) of sinus, thorax and and other relevant sites. Results: Fungal infection rate was 15%, while IRA was detected in 22 patients. Thirteen of these patients were male. Fifteen patients had hematological malignancies, 6 had solid tumors and one patient had combined immunodeficiency and hemophagocytic lymphohistiocytosis. All patients had absolute neutrophil count of zero for 5 to 30 days (median 11.5 days). IRA cases were classified as definite (n:3), probable (n:7) and possible (n:12) according to European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group. Amphotericin B was administered emprically to all cases and continued as a single agent in 7 patients. Variable modifications with caspofungin, voriconazole or itraconazole were done in 11, 9 and 2 patients, respectively. At present, 7 patients are disease-free after completion of treatment, 6 patients are still on antifungal therapy, 4 patients were lost despite antifungal therapy and 5 patients died of underlying disease while in remission or with stabile disease for a median of 339 days (range: 13–1027 days). Therefore, our remission rate and overall survival rates are 83% and 60% respectively. Conclusions: Contrary to the previous reports, we suggest that IRA is a treatable disease with early diagnosis and aggressive antifungal therapy and it is worthwhile to screen FNP patients who are resistant to wide-spectrum antibiotics with CT for early intervention. No significant financial relationships to disclose.
Abstract 12915: Myocardial Contractile Reserve: a Global Approach by Combining Cardiopulmonary Exercise Test With Exercise-Echocardiography
Authors: Francesco Bandera, Greta Generati, Marta Pellegrino, Valeria Donghi, Eleonora Alfonzetti, Marco Guazzi
Journal: Circulation (2013)

Purpose: several approaches are available to evaluate myocardial contractile reserve during exercise. Cardiopulmonary exercise test (CPET) allows a response characterization by well established var...
Experimental study on Chinese ink as the dye for the sentinel lymph node biopsy
Authors: S. Wang, K. Xu, X. Liu, Q. Zhou, Q. Geng, Q. Geng
Journal: Journal of Clinical Oncology (2006)

10785 Background: Sentinel lymph node biopsy (SLNB) is a very important method in detecting lymph nodes metastasis. There are several methods developed to detect sentinel lymph node. In this study, we will research on sentinel lymph node biopsy (SLNB) by using Chinese ink and study on its feasibility, clinical value and suitable concentration. Methods: Forty-two female rabbits were randomly divided into seven groups with 12 sides of mammaries (6 animals) in each group.The second mammary and the armpit of the same side were anatomized and injected 0.1 ml different dyes (1% isosulfan blue, 0.1%, 1%, 10%, 20%, 50%, 100% sterilized Chinese ink) at the base of the second mammary. We observed the dying time of the sentinel and the second lymph nodes and the fading time of the dying nodes. The pathological and histological examination of the sentinel lymph nodes were conducted in 5 minutes,1 hour and 2 weeks after the nodes were dyed by ink, respectively. The rabbits’ hearts, lungs, livers and kidneys were detected pathologic changes. Results: There was no obvious difference among different concentration ink on the dyeing time of the sentinel and second lymph nodes (P &gt; 0.05),but distinctively different from 1% isosulfan blue (P &lt; 0.05). There was no obvious difference between groups on the number of the dyed nodes (P &gt; 0.05). But the nodes dyed by 0.1% ink were dyed too lightly to be found. The average fading time of the nodes dyed by 1% isosulfan bluewas 33.9 minutes, and the nodes dyed by ink were still dyed deeply 2 weeks after the experiment. The pathologic examination showed that the carbon aggregated in the lymph nodes sinus 5 minutes after the nodes were dyed, but was phagocytosed by Macrophage (MΦ) 1 hour after dyed. The groups (0.1%, 1%, 10% ink) showed good histology image, however, groups (20%, 50%, 100% ink) showed too much carbon aggregation to disturb the observation. There were no difference in blood routine and pathologic change between these two groups. Conclusions: Chinese ink of concentration 1% to 10% is a useful dye of SLNB according chromaticity, histological observation and security. This dye had latency clinical value and was a new type of the dye for SLNB. No significant financial relationships to disclose.
A2.20 Synovial FCRl4+ B cells are enriched in citrulline reactivity without displaying signs of differentiation to a plasma cell phenotype
Authors: K Amara, E Clay, L Yeo, D Ramsköld, J Spengler, N Sippl, L Israelsson, P Titcombe, C Grönwall, A Filer, K Raza, V Malmström, D Scheel-Toellner
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background and objectives</h3> Expression of Fc Receptor like 4 (FcRL4) identifies a memory B cell subset, which is enriched in the joints of patients with rheumatoid arthritis (RA) and in mucosa associated lymphoid tissue. Their high level of RANKL production indicates a unique pathogenic role. Here, B cell receptor characteristics, antigen specificity and transcriptomic profile of FcRL4<sup>+</sup> B cells sorted from the joints of RA patients were investigated. <h3>Materials and methods</h3> FcRL4<sup>+</sup> and FcRL4<sup>- </sup>B cells were sorted from synovial fluid (SF) and tissue of patients with active RA. Their immunoglobulin variable region (IgVH) genes were sequenced and expressed to generate recombinant monoclonal antibodies (mAbs). Reactivity of 63 mAbs towards native and citrullinated peptides derived from α-enolase, fibrinogen, vimentin, histones 3 and 4 was determined by ELISA and Phadia's ImmunoCAP ISAC microarray system. RNA sequencing was carried out on sorted SF FcRL4<sup>+</sup> and FcRL4<sup>-</sup> B cells. After preamplification using the SMARTer amplification kit, library preparation was carried out using Illumina's TruSeq Stranded prep and sequenced on the Illumina platform. Data analysis was carried out using the programs rna-star, DESeq2 and ToppGene. <h3>Results</h3> Analysis of IgVH genes usage in FcRL4<sup>+</sup> and FcRL4<sup>-</sup> B cells indicated that the Ig repertoire was highly diverse in both B cell subsets, however <i>VH1–69</i> gene segment was significantly over-represented in the FcRL4<sup>+</sup> B cell population (P = 0.013). Out of the 63 mAbs tested, eight antibodies displayed high level of binding to citrullinated peptides. These were exclusively derived from the FcRL4<sup>+</sup> subset (p = 0.018). Another eleven antibodies showed low levels of binding to citrullinated peptides. These were derived from both FcRL4<sup>+</sup> and FcRL4<sup>-</sup> B cells. Global transcriptome analysis showed clear differences between the two B cell subsets, including 64 genes which were significantly over or under-expressed in FcRL4<sup>+</sup> B cells. Among the genes underexpressed in FcRL4+ B cells, the majority were associated with antibody production and plasma cell differentiation. <h3>Conclusions</h3> Reactivity of FcRL4<sup>+</sup> B cells towards citrullinated autoantigens suggests that they are a component of the citrulline-specific autoimmune response, however, their low level of expression of immunoglobulin and plasma cell differentiation genes suggests functions alternative to antibody production.