Treatment of Blood Cholesterol to Reduce Risk for Atherosclerotic Cardiovascular Disease
Authors: Donald M. Lloyd-Jones, David C. Goff, Neil J. Stone
Journal: Annals of Internal Medicine (2016)

Letters19 January 2016Treatment of Blood Cholesterol to Reduce Risk for Atherosclerotic Cardiovascular DiseaseDonald M. Lloyd-Jones, MD, ScM, David C. Goff, MD, PhD, and Neil J. Stone, MDDonald M. Lloyd-Jones, MD, ScMFrom Northwestern Medicine, Chicago, Illinois, and Colorado School of Public Health, Aurora, Colorado.Search for more papers by this author, David C. Goff, MD, PhDFrom Northwestern Medicine, Chicago, Illinois, and Colorado School of Public Health, Aurora, Colorado.Search for more papers by this author, and Neil J. Stone, MDFrom Northwestern Medicine, Chicago, Illinois, and Colorado School of Public Health, Aurora, Colorado.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-0520 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Mittleman and colleagues' article (1) is aptly named. Taylor is well beyond the guidelines in his interpretation of the accepted evidence base on cardiovascular prevention with statins and with his mathematical gymnastics.First, he selectively and incorrectly cites references. To support his claim that the 2013 risk estimator overestimates risk, Taylor cites 1 non–peer-reviewed opinion piece (without citing the rebuttal published alongside it) (2); 1 peer-reviewed study of heavily treated female health professionals enrolled in a trial of aspirin for primary prevention (3); 1 study that did not even evaluate the calibration of the risk score, which ...References1. Mittleman MA, Taylor WC, Smetana G, Burns RB. Treatment of blood cholesterol to reduce risk for atherosclerotic cardiovascular disease: grand rounds discussion from the Beth Israel Deaconess Medical Center. Ann Intern Med. 2015;163:280-90. [PMID: 26280414]. doi:10.7326/M15-1125 LinkGoogle Scholar2. Ridker PM, Cook NR. Statins: new American guidelines for prevention of cardiovascular disease. Lancet. 2013;382:1762-5. [PMID: 24268611] doi:10.1016/S0140-6736(13)62388-0 CrossrefMedlineGoogle Scholar3. Cook NR, Ridker PM. Further insight into the cardiovascular risk calculator: the roles of statins, revascularizations, and underascertainment in the Women's Health Study. JAMA Intern Med. 2014;174:1964-71. [PMID: 25285455] doi:10.1001/jamainternmed.2014.5336 CrossrefMedlineGoogle Scholar4. Pencina MJ, Navar-Boggan AM, D'Agostino RB, Williams K, Neely B, Sniderman AD, et al. Application of new cholesterol guidelines to a population-based sample. N Engl J Med. 2014;370:1422-31. [PMID: 24645848] doi:10.1056/NEJMoa1315665 CrossrefMedlineGoogle Scholar5. Muntner P, Colantonio LD, Cushman M, Goff DC, Howard G, Howard VJ, et al. Validation of the atherosclerotic cardiovascular disease Pooled Cohort risk equations. JAMA. 2014;311:1406-15. [PMID: 24682252] doi:10.1001/jama.2014.2630 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Northwestern Medicine, Chicago, Illinois, and Colorado School of Public Health, Aurora, Colorado.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0520. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTreatment of Blood Cholesterol to Reduce Risk for Atherosclerotic Cardiovascular Disease Murray A. Mittleman , William C. Taylor , Gerald Smetana , and Risa B. Burns Treatment of Blood Cholesterol to Reduce Risk for Atherosclerotic Cardiovascular Disease William C. Taylor Metrics Cited byEffects of Extracts from Tiaozhi Granule and Its Components on Expression of Scavenger Receptor Class B Type I 19 January 2016Volume 164, Issue 2Page: 135KeywordsBloodCardiovascular diseasesDisclosureLungsMyocardial infarctionPatient advocacyPreventive medicineRespiratory system proceduresStatinsTreatment guidelines ePublished: 19 January 2016 Issue Published: 19 January 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...