tbuckley/cabot-search huggingface dataset:
Poor-Risk Testicular Cancer and High-Dose Chemotherapy
Authors: Robert J. Motzer, Joel Sheinfeld
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.08.902 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 14568986 Poor-Risk Testicular Cancer and High-Dose Chemotherapy Robert J. MotzerxRobert J. MotzerSearch for articles by this author , Joel SheinfeldxJoel SheinfeldSearch for articles by this author Show More Memorial Sloan-Kettering Cancer Center, New York, NY https://doi.org/10.1200/JCO.2003.08.902 Full Text PDF Figures and Tables "Poor-Risk Testicular Cancer and High-Dose Chemotherapy." Journal of Clinical Oncology, 21(22), pp. 4073–4074© 2003 by American Society of Clinical Oncology
Prediction of Diabetic Foot Ulcer Occurrence Using Commonly Available Clinical Information
Authors: Edward J. Boyko, Jessie H. Ahroni, Victoria Cohen, Karin M. Nelson, Patrick J. Heagerty
Journal: Diabetes Care (2006)

The ability of readily available clinical information to predict the occurrence of diabetic foot ulcer has not been extensively studied. We conducted a prospective study of the individual and combined effects of commonly available clinical information in the prediction of diabetic foot ulcer occurrence.We followed 1,285 diabetic veterans without foot ulcer for this outcome with annual clinical evaluations and quarterly mailed questionnaires to identify foot problems. At baseline we assessed age; race; weight; current smoking; diabetes duration and treatment; HbA(1c) (A1C); visual acuity; history of laser photocoagulation treatment, foot ulcer, and amputation; foot shape; claudication; foot insensitivity to the 10-g monofilament; foot callus; pedal edema; hallux limitus; tinea pedis; and onychomycosis. Cox proportional hazards modeling was used with backwards stepwise elimination to develop a prediction model for the first foot ulcer occurrence after the baseline examination.At baseline, subjects were 62.4 years of age on average and 98% male. Mean follow-up duration was 3.38 years, during which time 216 foot ulcers occurred, for an incidence of 5.0/100 person-years. Significant predictors (P </= 0.05) of foot ulcer in the final model (hazard ratio, 95% CI) included A1C (1.10, 1.06-1.15), impaired vision (1.48, 1.00-2.18), prior foot ulcer (2.18, 1.61-2.95), prior amputation (2.57, 1.60-4.12), monofilament insensitivity (2.03, 1.50-2.76), tinea pedis (0.73, 0.54-0.98), and onychomycosis (1.58, 1.16-2.16). Area under the receiver operating characteristic curve was 0.81 at 1 year and 0.76 at 5 years.Readily available clinical information has substantial predictive power for the development of diabetic foot ulcer and may help in accurately targeting persons at high risk of this outcome for preventive interventions.
Correlations between physiological variables and performance in high level cross country off road cyclists
Authors: F M Impellizzeri, S M Marcora, E Rampinini, P Mognoni, A Sassi
Journal: British Journal of Sports Medicine (2005)

To examine the relations between maximal and submaximal indices of aerobic fitness and off road cycling performance in a homogeneous group of high level mountain bikers.12 internationally competitive mountain bikers completed the study. Maximum oxygen uptake (Vo(2max)), peak power output (PPO), power output (PO), and oxygen uptake (Vo(2)) at first (VT) and second (RCT) ventilatory thresholds were measured in the laboratory, and correlated with race time during a cross country circuit race.The only physiological indices of aerobic fitness correlated with off road cycling performance were PO and Vo(2) at RCT when normalised to body mass (r = -0.63 and r = -0.66, respectively; p<0.05). VT, Vo(2max), and PPO were not correlated to performance in this homogeneous group of high level mountain bikers.The results of this study suggest that submaximal indices of aerobic fitness such as PO and Vo(2) at RCT are more important determinants of off road cycling performance than maximal indices such as PPO and Vo(2max). This study confirms the importance of body mass for mountain biking performance. As aerobic fitness explained only 40% of the variance, other physiological and technical factors should be investigated, as they may be important determinants of cross country performance among elite mountain bikers.
Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.
Authors: P R Burd, H W Rogers, J R Gordon, C A Martin, S Jayaraman, S D Wilson, A M Dvorak, S J Galli, M E Dorf
Journal: The Journal of Experimental Medicine (1989)

In response to IgE and specific multivalent antigen, mast cell lines (both growth factor-dependent and -independent) induce the transcription and/or secretion of a number of cytokines having a wide spectrum of activities. We have identified IL-1, IL-3, IL-5, IL-6, IFN-gamma, GM-CSF, JE, MIP1 alpha, MIP1 beta, and TCA3 RNA in at least two of four mast cell clones. The production of these products (except JE) is activation-associated and can be induced by IgE plus antigen. In selected instances cytokine expression can also be induced by activation with Con A or phorbol ester plus ionophore, albeit to levels less than those observed with IgE plus antigen. In addition, long-term mast cell clones and primary cultures of bone marrow-derived mast cells specifically release IL-1, IL-4, and/or IL-6 bioactivity after activation. These findings suggest that in addition to their inflammatory effector function mast cells may serve as a source of growth and regulatory factors. The relationship of mast cells to cells of the T lymphocyte lineage is discussed.
Testicular sperm extraction prior to treatment in azoospermic patients with Hodgkin’s disease
Authors: M. Schrader, M. Müller, N. Sofikitis, C. Goessl, B. Straub, K. Miller
Journal: Annals of Oncology (2002)

We read with great interest the recent paper by Rueffer et al. [1.Rueffer U. Breuer K. Josting A. et al.Male gonadal dysfunction in patients with Hodgkin’s disease prior to treatment.Ann Oncol. 2001; 12: 1307-1311Abstract Full Text PDF PubMed Scopus (155) Google Scholar]. The authors of this multicenter study point out that even before polychemotherapy, abnormal semen quality is detected in 70% of patients and azoospermia (absence of spermatozoa in the semen) in 13%. The causes they discuss are diverse parameters responsible for severe fertility disorders in conjunction with Hodgkin’s disease (HD), including increased serum interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)-α levels, tumor-associated fever and other factors. The authors also state that successful treatment of HD may lead to recovery of fertility, but only if the chemotherapy regimen does not contain gonadotoxic drugs. Problematic here is the fact that the polychemotherapeutic regimen for HD frequently includes gonadotoxic substances that cause an additional fertility disorder [2, 3.Kulkarni S.S. Sastry P.S. Saikia T.K. et al.Gonadal function following ABVD therapy for Hodgkin’s disease.Am J Clin Oncol. 1997; 20: 354-357Crossref PubMed Scopus (61) Google Scholar]. The authors rightly point out that cryopreservation of ejaculated sperm prior to treatment is thus an important step towards protecting fertility. However, this recommendation is not valid for patients with azoospermia, since cryopreservation of ejaculate is of no help in such cases. Based on our experience, we recommend testicular sperm extraction with cryopreservation of testicular biopsy specimens prior to treatment of patients with HD and azoospermia [4.Schrader M. Heicappell R. Müller M. et al.Impact of chemotherapy on male fertility.Onkologie. 2001; 24: 326-330Crossref PubMed Scopus (34) Google Scholar]. We successfully recovered haploid germ cells in four of 12 testicular biopsies from azoospermic men with HD. Maturation arrest was found in four of 12 cases and Sertoli-cell-only syndrome in the rest. None of the patients had secondary healing or a treatment delay because of the testicular biopsy. We think that testicular sperm extraction (TESE) should definitely be considered for azoospermic HD patients and offered as a treatment option in selected cases.
Computers and the Diagnosis of Pneumonia
Authors: Walid F. Gellad, Donald Yealy, Michael Fine
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
20% of patients may refuse consent to disclosure of information for Benefits Agency
Authors: S. J Ellis
Journal: BMJ (1997)

<h3>Abstract</h3> Computational methods for virtual screening can dramatically accelerate early-stage drug discovery by identifying potential hits for a specified target. Docking algorithms traditionally use physics-based simulations to address this challenge by estimating the binding orientation of a query protein-ligand pair and a corresponding binding affinity score. Over the recent years, classical and modern machine learning architectures have shown potential for outperforming traditional docking algorithms. Nevertheless, most learning-based algorithms still rely on the availability of the protein-ligand complex binding pose, typically estimated via docking simulations, which leads to a severe slowdown of the overall virtual screening process. A family of algorithms processing target information at the amino acid sequence level avoid this requirement, however at the cost of processing protein data at a higher representation level. We introduce deep neural virtual screening (DENVIS), an end-to-end pipeline for virtual screening using graph neural networks (GNNs). By performing experiments on two benchmark databases, we show that our method performs competitively to several docking-based, machine learning-based, and hybrid docking/machine learning-based algorithms. By avoiding the intermediate docking step, DENVIS exhibits several orders of magnitude faster screening times (i.e., higher throughput) than both docking-based and hybrid models. When compared to an amino acid sequence-based machine learning model with comparable screening times, DENVIS achieves dramatically better performance. Some key elements of our approach include protein pocket modelling using a combination of atomic and surface features, the use of model ensembles, and data augmentation via artificial negative sampling during model training. In summary, DENVIS achieves competitive to state-of-the-art virtual screening performance, while offering the potential to scale to billions of molecules using minimal computational resources. <h3>Graphical TOC Entry</h3>
PSYCHOLOGICAL FACTORS IN MEN WITH PEPTIC ULCERS
Authors: FREDERIC T. KAPP, MILTON ROSENBAUM, JOHN ROMANO
Journal: American Journal of Psychiatry (1947)

Twenty men with peptic ulcers were studied from the psychosomatic point of view. None were psychologically mature. All of them had strong dependent desires which were secondary to either rejection or spoiling in early childhood. One group utilized the mechanism of overcompensation to deny these desires, resulting in the overt character picture of the driving, hard-working, ambitious business man. However, we found that the majority of our patients in a charity hospital were either outwardly passive and effeminate or openly acted out their deep oral desires. Ulcer symptoms developed in all of our patients as responses to frustration of these cravings, when the various defense mechanisms they used to handle such conflicts proved inadequate.
The Effect of Adrenaline, Noradrenaline, and Propranolol on Myocardial Blood Flow and Metabolic Heat Production in Monkeys and Baboons
Authors: J. R. Parratt
Journal: Cardiovascular Research (1969)

The effects of adrenaline and noradrenaline on myocardial blood flow and metabolic heat production in monkeys and baboons were studied before and after propranolol. After β-adrenotropic blockade, the action of catecholamines on myocardial vascular resistance was reduced or reversed. Adrenaline-induced changes in "corrected temperature" (an index of local metabolic heat production) were markedly reduced by propranolol. It is suggested that this may be related to the beneficial effects of this drug in angina.
Collodictyon--An Ancient Lineage in the Tree of Eukaryotes
Authors: S. Zhao, F. Burki, J. Brate, P. J. Keeling, D. Klaveness, K. Shalchian-Tabrizi
Journal: Molecular Biology and Evolution (2012)

The current consensus for the eukaryote tree of life consists of several large assemblages (supergroups) that are hypothesized to describe the existing diversity. Phylogenomic analyses have shed light on the evolutionary relationships within and between supergroups as well as placed newly sequenced enigmatic species close to known lineages. Yet, a few eukaryote species remain of unknown origin and could represent key evolutionary forms for inferring ancient genomic and cellular characteristics of eukaryotes. Here, we investigate the evolutionary origin of the poorly studied protist Collodictyon (subphylum Diphyllatia) by sequencing a cDNA library as well as the 18S and 28S ribosomal DNA (rDNA) genes. Phylogenomic trees inferred from 124 genes placed Collodictyon close to the bifurcation of the "unikont" and "bikont" groups, either alone or as sister to the potentially contentious excavate Malawimonas. Phylogenies based on rDNA genes confirmed that Collodictyon is closely related to another genus, Diphylleia, and revealed a very low diversity in environmental DNA samples. The early and distinct origin of Collodictyon suggests that it constitutes a new lineage in the global eukaryote phylogeny. Collodictyon shares cellular characteristics with Excavata and Amoebozoa, such as ventral feeding groove supported by microtubular structures and the ability to form thin and broad pseudopods. These may therefore be ancient morphological features among eukaryotes. Overall, this shows that Collodictyon is a key lineage to understand early eukaryote evolution.
Effects of cannabis on pulmonary structure, function and symptoms
Authors: S. Aldington, M. Williams, M. Nowitz, M. Weatherall, A. Pritchard, A. McNaughton, G. Robinson, R. Beasley
Journal: Thorax (2007)

<h3>Background:</h3> Cannabis is the most widely used illegal drug worldwide. Long-term use of cannabis is known to cause chronic bronchitis and airflow obstruction, but the prevalence of macroscopic emphysema, the dose-response relationship and the dose equivalence of cannabis with tobacco has not been determined. <h3>Methods:</h3> A convenience sample of adults from the Greater Wellington region was recruited into four smoking groups: cannabis only, tobacco only, combined cannabis and tobacco and non-smokers of either substance. Their respiratory status was assessed using high-resolution CT (HRCT) scanning, pulmonary function tests and a respiratory and smoking questionnaire. Associations between respiratory status and cannabis use were examined by analysis of covariance and logistic regression. <h3>Results:</h3> 339 subjects were recruited into the four groups. A dose-response relationship was found between cannabis smoking and reduced forced expiratory volume in 1 s to forced vital capacity ratio and specific airways conductance, and increased total lung capacity. For measures of airflow obstruction, one cannabis joint had a similar effect to 2.5–5 tobacco cigarettes. Cannabis smoking was associated with decreased lung density on HRCT scans. Macroscopic emphysema was detected in 1/75 (1.3%), 15/92 (16.3%), 17/91 (18.9%) and 0/81 subjects in the cannabis only, combined cannabis and tobacco, tobacco alone and non-smoking groups, respectively. <h3>Conclusions:</h3> Smoking cannabis was associated with a dose-related impairment of large airways function resulting in airflow obstruction and hyperinflation. In contrast, cannabis smoking was seldom associated with macroscopic emphysema. The 1:2.5–5 dose equivalence between cannabis joints and tobacco cigarettes for adverse effects on lung function is of major public health significance.
β-Catenin Activation Is Associated with Specific Clinical and Pathologic Characteristics and a Poor Outcome in Adrenocortical Carcinoma
Authors: Sébastien Gaujoux, Sophie Grabar, Martin Fassnacht, Bruno Ragazzon, Pierre Launay, Rossella Libé, Ilham Chokri, Anne Audebourg, Benedict Royer, Silviu Sbiera, Marie-Cécile Vacher-Lavenu, Bertrand Dousset, Xavier Bertagna, Bruno Allolio, Jérôme Bertherat, Frédérique Tissier
Journal: Clinical Cancer Research (2010)

Activation of the Wnt/β-catenin signaling pathway is frequent in adrenocortical carcinoma (ACC) and might be associated with a more aggressive phenotype. The objective of this study was to assess the prognostic value of β-catenin immunohistochemistry and CTNNB1 (β-catenin gene)/APC (adenomatous polyposis coli gene) mutations in patients with resected primary ACC.In 79 patients with resected primary ACC from a French cohort (Cochin-COMETE), β-catenin expression was assessed on tumor specimens by immunohistochemistry. For patients with available DNA (n = 49), CTNNB1, and APC hotspot (mutation cluster region), were sequenced. Association between these results and the clinicopathologic characteristics of the ACC and overall and disease-free survival were studied. Results were confirmed on a tissue microarray from an independent multicentric cohort of 92 ACC from Germany (German-ENSAT cohort).In the Cochin-COMETE cohort, the presence of a β-catenin nuclear staining was significantly associated with a higher ENSAT tumor stage (i.e., stages III and IV), higher Weiss score, more frequent necrosis, mitoses, and CTNNB1/APC mutations. β-Catenin nuclear staining and the presence of CTNNB1/APC mutations were both associated with decreased overall and disease-free survival, and were independent predictive factors of survival in multivariate analysis. The same results were observed in the German-ENSAT cohort.Wnt/β-catenin activation, confirmed by the presence of β-catenin nuclear staining, is an independent prognostic factor of overall and disease-free survival in patients with resected primary ACC.
Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4).
Authors: M B Widmer, R B Acres, H M Sassenfeld, K H Grabstein
Journal: The Journal of Experimental Medicine (1987)

The effects of B cell stimulatory factor 1 (BSF-1) on the generation of human CTL and lymphokine-activated killer (LAK) cells in vitro were investigated. Both L-2 and BSF-1 were potent helper factors for the generation of antigen-specific CTL in MLC; detection of optimal BSF-1-induced CTL activity in this system occurred when BSF-1 was added to cultures after an initial period of activation during which exogenous BSF-1 was not present. In contrast to IL-2, BSF-1 failed to induce an LAK cell population, as detected with Daudi tumor targets, in cultures that had not been allosensitized. Furthermore, when both lymphokines were added together at culture initiation, BSF-1 inhibited the IL-2-driven generation of cytolytic cells. The differential ability of BSF-1 to promote the generation of CTL but not LAK could have important implications for lymphokine-mediated immunotherapy.
Tuberculosis: cost of illness in Germany
Authors: Roland Diel, Stefan Rutz, Stefanie Castell, Tom Schaberg
Journal: European Respiratory Journal (2012)

4,444 new cases of tuberculosis (TB) were reported in Germany in 2009; of those, the proportion of multidrug-resistant (MDR)-TB cases increased to 2.1% (63 cases). On the basis of the therapy guidelines of the German Central Committee against Tuberculosis and the new World Health Organization guidelines, this study estimates the mean direct outpatient and combined in- and outpatient costs of TB, together with other attributable costs of the disease on the basis of the most recent German official health statistics and scientific literature. According to this, the mean outpatient costs (rounded) per case were €1,197 (adults) and €1,006 (children) for standard therapy, but €36,543 for treatment of MDR-TB. The mean combined in-patient/outpatient costs were €7,364 (adults) and €7,300 (children), respectively; the combined costs for treatment of MDR-TB amounted to €52,259. Including MDR-TB cases the mean costs of treatment per TB case were €7,931. These are joined by the mean costs due to loss of productivity (€2,313), costs per case for rehabilitation (€74) and contact tracing (€922), adding up to €11,240. When considering the probability of increasing numbers of MDR-TB cases in the near future, TB is still a disease of significant economic impact in Germany.
Regulatory T Cell–Derived IL-10 Ameliorates Crescentic GN
Authors: Annett Ostmann, Hans-Joachim Paust, Ulf Panzer, Claudia Wegscheid, Sonja Kapffer, Samuel Huber, Richard A. Flavell, Annette Erhardt, Gisa Tiegs
Journal: Journal of the American Society of Nephrology (2013)

Regulatory T cells (Tregs) exert their immunosuppressive activity through several immunoregulatory mechanisms, including the production of anti-inflammatory cytokines such as IL-10. Although several studies suggest a role for Tregs in modulating crescentic GN, the underlying mechanisms are not well understood. Here, using IL-10 reporter mice, we detected IL-10–producing Foxp3+ T cells in the kidney, blood, and secondary lymphoid tissue in a mouse model of crescentic GN. Specific inactivation of Il10 in Foxp3+ Tregs eliminated the ability of these cells to suppress renal and systemic production of IFNγ and IL-17; these IL-10–deficient Tregs lost their capacity to attenuate renal tissue injury. These data highlight the suppressive functions of Tregs in crescentic GN and suggest the importance of Treg-derived IL-10 in ameliorating disease severity and in modulating both the Th1 and most notably Th17 immune response.