tbuckley/cabot-search huggingface dataset:
Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation
Authors: Andrea M. Siegel, Kelly D. Stone, Glenn Cruse, Monica G. Lawrence, Ana Olivera, Mi-yeon Jung, John S. Barber, Alexandra F. Freeman, Steven M. Holland, Michelle O'Brien, Nina Jones, Laura B. Wisch, Heidi H. Kong, Avanti Desai, Orly Farber, Alasdair M. Gilfillan, Juan Rivera, Joshua D. Milner
Journal: Journal of Allergy and Clinical Immunology (2013)
Spend, spend, spend
Authors: Liam Farrell
Journal: BMJ (2006)

Like every family doctor I have many patients on long waiting lists, some with major pain and disability that could be rectified by prompt intervention. Even if we don't like it we can understand why this situation exists.

We know that the health service can't do everything—the sick will always be with us, people are living longer than ever before, new and expensive diagnostic tests and treatments are constantly coming on stream, …
Comparison of skill performance among tribal and non-tribal soccer players in relation to their motor fitness and anthropometric dimensions
Authors: Pranakrishna Rout, Ashok K Nayak
Journal: British Journal of Sports Medicine (2010)

Present study has been aimed to find out the difference of soccer skill performance between tribal and non-tribal soccer players of Odisha state, with respect to their anthropometric dimensions and motor fitness. The study investigated tribal soccer players of mean age 15.54 years from sports club, sports hostels and schools of western region of the state of Orissa (tribal origin) only. It also included non-tribal soccer players mean age 15.54 year were selected as samples from urban area of western region of Odisha state. The groups of sample selected for investigation participated in competitions held at district level and above. An anthropometric measurement of eight items has been taken of all subjects to assess soccer skill performance. The established Cooper's JCR motor fitness was administered to each subject. After sufficient rest, Warner Soccer Skill Test items were also administered to each sample. The data obtained from the investigation were analysed statistically. The analysis yielded significant difference between the two groups of soccer players with respect to height and ankle circumference parameters. However non-tribal soccer players are significantly more heighted than the tribal soccer players. But tribal players are superior to non-tribal soccer player with respect to ankle circumstances. It is concluded that the skill performance of soccer players with good motor fitness and more ankle circumference would be better than the performance skill of the player with poor motor fitness and less ankle circumstances. There is little difference between tribal and non-tribal soccer player with respect to the soccer skill performance.
Elevations in arterial pressure induce the formation of spontaneous action potentials and alter neurotransmission in canine ileum arteries.
Authors: J S Smeda, E E Daniel
Journal: Circulation Research (1988)

Arterial segments (less than 250 micron o.d.) excised from canine ileum were mounted in a chamber that permitted arterial transmural pressure (TMP) to be altered and measured. Subsequently, the periarterial nerves were field stimulated with single pulses (0.1 msec, 70 V), and the resting membrane potential (Em) as well as the nerve-mediated alterations in smooth muscle Em were measured using intracellular microelectrodes at TMPs between 0 and 160 mm Hg. The resting Em was greatest at TMPs of 40 mm Hg (-54.7 +/- 2.6 mV) and depolarized as the TMP was increased, reaching a value of -44.8 +/- 3.1 mV at 160 mm Hg. At TMP greater than or equal to 60 mm Hg, a proportion of the preparations exhibited spontaneous electrical activity (SA) consisting of constant rhythmic oscillations in Em or action potentials (APs) or of trains of rhythmic APs that progressively decreased in amplitude, interrupted by periods of hyperpolarization. SA stopped when the TMP was lowered to 40 mm Hg and was reestablished when the TMP was reelevated to TMPs above 60 mm Hg. Nerve stimulation evoked excitatory junction potentials (ejps) or APs. At constant stimulus parameters, ejps of maximum amplitude having the greatest rate of potential rise and fall were produced at TMP of 100 mm Hg. At TMPs greater than 100 mm Hg or less than 100 mm Hg, the amplitude and the rate of rise and fall of the ejps decreased. Ejps formed in response to a constant single pulse stimulus (0.1 msec, 70 V) elicited APs only at TMPs greater than or equal to 60 mm Hg. Neither ejps nor APs were inhibited by alpha-receptor-blocking agents. These studies indicate that the TMP at which an artery is maintained plays an important role in determining the resting Em, the occurrence of spontaneous action potentials, and the alterations in Em associated with nerve stimulation.
Allergen-Specific IgG and IgG4 Autoanalyzer Performance and Utility In Assessing Immunotherapy (IT) Study Specimens
Authors: R HAMILTON, D HOVANECBURNS, K BOURCIER, G LACK, J FRANCIS, R AALBERSE, S DURHAM, V SEYFERTMARGOLIS
Journal: Journal of Allergy and Clinical Immunology (2008)
Multifocal Renal Cancer: Genetic Basis and Its Medical Relevance
Authors: Donald P. Bottaro, W. Marston Linehan
Journal: Clinical Cancer Research (2005)

More than 36,000 new cases of kidney cancer, accounting for 3% of all adult malignancies, are projected to be diagnosed in the United States in 2005, the majority of which are RCC. Furthermore, over 12,000 deaths annually in the United States are attributed to RCC, and the overall incidence of RCC
Androgen Deprivation Therapy for Localized Prostate Cancer and the Risk of Cardiovascular Mortality
Authors: H. K. Tsai, A. V. D'Amico, N. Sadetsky, M.-H. Chen, P. R. Carroll
Journal: JNCI Journal of the National Cancer Institute (2007)

We investigated whether androgen deprivation therapy (ADT) use is associated with an increased risk of death from cardiovascular causes in patients treated for localized prostate cancer.From the Cancer of the Prostate Strategic Urologic Research Endeavor database, data on 3262 patients treated with radical prostatectomy and 1630 patients treated with external beam radiation therapy, brachytherapy, or cryotherapy for localized prostate cancer were included in this analysis. Competing risks regression analyses were performed to assess whether use of ADT was associated with a shorter time to death from cardiovascular causes after controlling for age (as a continuous variable) and the presence of baseline cardiovascular disease risk factors. All tests for statistical significance were two-sided.The median follow-up time was 3.8 years (range = 0.1-11.3 years). Among the 1015 patients who received ADT, the median duration of ADT use was 4.1 months (range = 1.0-32.9 months). In a competing risks regression analysis that controlled for age and risk factors for cardiovascular disease, both ADT use (adjusted hazard ratio [HR] = 2.6; 95% confidence interval [CI] = 1.4 to 4.7; P = .002) and age (adjusted HR = 1.07; 95% CI = 1.02 to 1.1; P = .003) were associated with statistically significantly increased risks of death from cardiovascular causes in patients treated with radical prostatectomy. Among patients 65 years or older treated with radical prostatectomy, the 5-year cumulative incidence of cardiovascular death was 5.5% (95% CI = 1.2% to 9.8%) in those who received ADT and 2.0% (95% CI = 1.1% to 3.0%) in those who did not. Among patients 65 years or older treated with external beam radiation therapy, brachytherapy, or cryotherapy, ADT use was associated with a higher cumulative incidence of death from cardiovascular causes, but the difference did not reach statistical significance.The use of ADT appears to be associated with an increased risk of death from cardiovascular causes in patients undergoing radical prostatectomy for localized prostate cancer.
Occurrence of restricted suppressor T-cell activity in man.
Authors: M A Bean, Y Kodera, K B Cummings, B R Bloom
Journal: The Journal of Experimental Medicine (1977)

Blood leukocytes from an immunologically hyporesponsive patient with urinary bladder carcinoma were found to be deficient in their ability to stimulate 3 of 27 responder leukocyte preparations from normal individuals in one-way mixed leukocyte culture (MLC). The patient's T-depleted leukocytes, however, functioned adequately as stimulator cells. T-enriched lymphocytes from this patient suppressed the MLC responsiveness of those three normals but not the responsiveness of other normals. The patient's cells suppressed the MLC responsiveness of only one of each of the parents of two of the normals who could be suppressed by the patient's leukocytes suggesting a possible genetic restriction to this suppressor cell activity.
Human platelets modulate edema formation in isolated rabbit lungs.
Authors: J E Heffner, J A Cook, P V Halushka
Journal: Journal of Clinical Investigation (1989)

The role of platelet glucose-6-phosphate dehydrogenase (G-6-PD) in mediating the effects of human platelets on oxidant-induced edema in the isolated perfused rabbit lung was investigated using dehydroepiandrosterone, a specific steroidal inhibitor of G-6-PD. Xanthine oxidase (0.003 and 0.012 U/ml) caused lung edema that was attenuated by coinfusion of washed human platelets. Platelets that were incubated with DEA to inhibit G-6-PD activity augmented xanthine oxidase-induced lung edema and pulmonary hypertension at both doses of xanthine oxidase. Infusion of papaverine to maintain stable pulmonary artery (PA) pressures, incubation of G-6-PD-inhibited platelets with acetylsalicylate, or infusion of a thromboxane-prostaglandin endoperoxide receptor site antagonist, SQ 29548, into the lung perfusate prevented augmentation of lung edema and the PA pressor response by G-6-PD-inhibited platelets. It was concluded that antioxidant-intact platelets attenuate oxidant-induced lung edema by preventing increased membrane permeability, and that G-6-PD-inhibited platelets augment lung edema through hydrostatic mechanisms mediated by release of platelet cyclooxygenase products.
Prediction of Venous Thromboembolism in Patients With Cancer by Measuring Thrombin Generation: Results From the Vienna Cancer and Thrombosis Study
Authors: Cihan Ay, Daniela Dunkler, Ralph Simanek, Johannes Thaler, Silvia Koder, Christine Marosi, Christoph Zielinski, Ingrid Pabinger
Journal: Journal of Clinical Oncology (2011)

Patients with cancer are at increased risk of venous thromboembolism (VTE). Laboratory tests measuring the overall thrombophilic tendency might be useful to assess VTE risk. The aim of this study was to investigate thrombin generation, a key process in hemostasis, as predictor of cancer-associated VTE.The Vienna Cancer and Thrombosis Study (CATS) is a prospective observational cohort study of patients with newly diagnosed cancer or progression of disease after remission. The study end point is occurrence of objectively confirmed symptomatic or fatal VTE within a follow-up period of 2 years. Thrombin generation was measured with a commercially available assay.One thousand thirty-three patients with malignancies of the breast (n = 151), lung (n = 148), upper (n = 44) and lower gastrointestinal tract (n = 125), pancreas (n = 67), kidney (n = 34), prostate (n = 122), and brain (n = 134) or lymphoma (n = 126), multiple myeloma (n = 26), and other tumor types (n = 56) were observed for a median observation period of 517 days. VTE occurred in 77 patients (7.5%). Patients with elevated peak thrombin (defined as values ≥ 611 nM thrombin, representing the 75th percentile of the total study population) had an increased risk of VTE with a hazard ratio of 2.1 (95% CI, 1.3 to 3.3, P = .002) in multivariable analysis including age, sex, surgery, chemotherapy, and radiotherapy. The cumulative probability of developing VTE after 6 months was significantly higher in patients with elevated peak thrombin than in those with lower peak thrombin (11% v 4%; log-rank test: P = .002).Measurement of thrombin generation may help identify patients with cancer at high risk of VTE.
Efficacy of the pulsed dye laser in the treatment of localized recalcitrant plaque psoriasis: a comparative study
Authors: A. Erceg, H.J. Bovenschen, P.C.M. Van De Kerkhof, M.M.B. Seyger
Journal: British Journal of Dermatology (2006)

Journal Article Efficacy of the pulsed dye laser in the treatment of localized recalcitrant plaque psoriasis: a comparative study Get access A. Erceg, A. Erceg Department of Dermatology, Radboud University Nijmegen Medical Centre, René Descartesdreef 1, PO Box 9101, 6525 GL Nijmegen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar H.J. Bovenschen, H.J. Bovenschen Department of Dermatology, Radboud University Nijmegen Medical Centre, René Descartesdreef 1, PO Box 9101, 6525 GL Nijmegen, the Netherlands H.J. Bovenschen. E‐mail: j.bovenschen@derma.umcn.nl Search for other works by this author on: Oxford Academic Google Scholar P.C.M. Van De Kerkhof, P.C.M. Van De Kerkhof Department of Dermatology, Radboud University Nijmegen Medical Centre, René Descartesdreef 1, PO Box 9101, 6525 GL Nijmegen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar M.M.B. Seyger M.M.B. Seyger Department of Dermatology, Radboud University Nijmegen Medical Centre, René Descartesdreef 1, PO Box 9101, 6525 GL Nijmegen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 1, 1 July 2006, Pages 110–114, https://doi.org/10.1111/j.1365-2133.2006.07141.x Published: 01 July 2006 Article history Accepted: 28 September 2005 Published: 01 July 2006
Doreen Mary Tillotson (née Robertshaw)
Authors: Peter Tillotson
Journal: BMJ (2007)

I should like to pay tribute to the life of our dearest mother, mother-in-law, and granny. One of the things we admired most about her was that she was always so modest about everything she did, so this tribute is pieced together from many fragments that had to be prized out of her over the years.

My mother was born on 21 May 1905—four years after Queen Victoria died—in Bradford, then the heart of the wool trade where her grandfather and great uncle had both founded mills (John Mitton & Co (Worsted Spinners) and Thomas Henry Shaw (Woolcombers)). Her father was a wool merchant. When he could not afford to send her to Bradford Girls' Grammar School, her teachers suggested she apply for a scholarship, and when she was awarded the top scholarship in the school, the director of education asked her parents to take her to meet him.

On leaving school in 1923 she went to Leeds University Medical School. It was not then common for girls to go there, and at 18 she was one of only four girls in her year, with just 18 girls in the whole of the medical school. Soon afterwards, her parents moved to Menston, which meant walking 20 minutes to Guiseley, half an hour on the bus to Leeds, and then walking another 15 minutes to the university, twice a day . At 23 she was visiting the slums of Leeds and doing locums in Sheffield and York, and, for a spell, she worked in TB clinics.

In 1929, a year after qualifying, she put her plate out in Menston and started a practice at the age …
A New Predictive Molecular Marker for Cetuximab Benefit in Rectal Cancer?
Authors: Thomas J. George, Michael J. O’Connell
Journal: JNCI Journal of the National Cancer Institute (2014)

Sclafani et al present data and suggest that tumor protein 53 (TP53) may be a predictive marker of cetuximab benefit in patients with rectal cancer undergoing neoadjuvant chemoradiation in this issue of the Journal (1). This article relies on an unplanned, retrospective analysis of molecular marker data on a subset of patients participating in the randomized phase II EXPERT-C clinical trial initially reported in 2012 (2). Patients with operable magnetic resonance imaging– defined high-risk rectal cancer received four cycles of capecitabine/ oxaliplatin (CAPOX) followed by capecitabine chemoradiotherapy, surgery, and adjuvant CAPOX (four cycles) or the same regimen plus weekly cetuximab (CAPOX-C). The primary endpoint was complete tumor response, which was modified during conduct of the study to include only the subset of patients whose tumors were KRAS/BRAF wild type. This was quite reasonably done when the impact of KRAS status on antitumor activity of epidermal growth factor receptor (EGFR)-inhibiting monoclonal antibodies was documented (3). However, the sample size of the study was not increased to assure the intended statistical power. One hundred and fifty eligible patients were randomly assigned. Based on a subset of patients with KRAS/BRAF wild-type tumors (46 patients who received cetuximab vs 44 patients who did not receive cetuximab as a component of treatment), the authors concluded that cetuximab led to a statistically significant increase in response rate and overall survival, but the primary end point of improved complete pathologic response was not met. Further follow-up revealed that contrary to the initial report, adding cetuximab was not associated with a statistically significant improvement in progression-free survival or overall survival in either KRAS/BRAF wild-type or unselected
The pleura and rheumatoid arthritis: A case series
Authors: Rahul Mukherjee, Mehreen Ahmad, Shiva Bikmalla, Vikas Punamiya, Sushil Agarwal, Richard Steyn
Journal: European Respiratory Journal (2012)

Background : Pleurisy is observed in almost 30% and effusions can be recurrent, occasionally leading to fibrothorax in chronic seropositive rheumatoid arthritis[ Chest 1991; 100 :235-238]. Pulmonary nodules occur in up to 5%, 50% cavitating to cause pneumothorax, haemoptysis or bronchopleural fistula.

![Figure][1] 



Recurrent pneumothoraces and effusions are difficult to manage by surgical decortication [ J Thor Cardiovasc Surg 1975; 68 : 347-354].

Case Series : We report four cases of chronic seropositive rheumatoid arthritis on longterm immunomodulator therapy, presenting with pleural effusions which were prone to recurrence & complicated by development of pneumothorax. The common theme was all had chest drains inserted initially, then surgical pleurodesis, re-presented with recurrent pleural effusions draining purulent material after failed pleurodesis and had indwelling pleural catheters inserted. One isolated Aspergillus species and died of multiorgan failure; the rest were left with indwelling chest drains.

Discussion : Our case series highlights the paucity of evidence in management of complicated rheumatoid pleural disease and calls for registries of interventions for such patients. It is important to initiate early conservative approach in management of rheumatoid pleural effusions as surgical management is problematic due to trapped lung and pleural rind. Opportunistic infections in the context of an ever expanding use of immunosuppressive treatments have to be borne in mind.

 [1]: pending:yes
Using SINEs to Probe Ancient Explosive Speciation: "Hidden" Radiation of African Cichlids?
Authors: Y. Terai
Journal: Molecular Biology and Evolution (2003)

Cichlid fishes of the east African Great Lakes represent a paradigm of adaptive radiation. We conducted a phylogenetic analysis of cichlids including pan-African and west African species by using insertion patterns of short interspersed elements (SINEs) at orthologous loci. The monophyly of the east African cichlids was consistently supported by seven independent insertions of SINE sequences that are uniquely shared by these species. In addition, data from four other loci indicated that the genera Tilapia (pan-African) and Steatocranus (west African) are the closest relatives to east African cichlids. However, relationships among Tilapia, Steatocranus, and the east African clade were ambiguous because of incongruencies among topologies suggested by insertion patterns of SINEs at six other loci. One plausible explanation for this phenomenon is incomplete lineage sorting of alleles containing or missing a SINE insertion at these loci during ancestral speciation. Such incomplete sorting may have taken place earlier than 14 MYA, followed by random and stochastic fixation of the alleles in subsequent lineages. These observations prompted us to consider the possibility that cichlid speciation occurred at an accelerated rate during this period when the African Great Lakes did not exist. The SINE method could be useful for detecting ancient exclusive speciation events that tend to remain hidden during conventional sequence analyses because of accumulated point mutations.
Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K
Authors: Gui Ren, Qifei Tian, Yanxin An, Bin Feng, Yuanyuan Lu, Jie Liang, Kai Li, Yulong Shang, Yongzhan Nie, Xin Wang, Daiming Fan
Journal: Molecular Cancer (2012)

Coronins are a family of highly evolutionary conserved proteins reportedly involved in the regulation of actin cytoskeletal dynamics, although only coronin 3 has been shown to be related to cancer cell migration. In glioblastoma cells, the knockdown of coronin 3 inhibits cell proliferation and invasion. Coronin 3 is also associated with the aggression and metastasis of hepatocellular carcinoma. In this paper, we analyze the migration, invasion and metastasis abilities of gastric cancer cells after up- or down-regulation of coronin 3, and explore the mechanism of coronin 3 in the process of gastric cancer metastasis.The expression of coronin 3 was higher in the highly metastatic sub-cell line MKN28-M, which we established in our laboratory. We also demonstrated that the expression of coronin 3 was remarkably higher in lymph lode metastases than in primary gastric cancer tissues, and over-expression of coronin 3 was correlated with the increased clinical stage and lymph lode metastasis. Recombinant lentiviral vectors encoding shRNAs were designed to down-regulate coronin 3 expression in gastric cancer cell lines. Stable knockdown of coronin 3 by this lentiviral vector could efficiently inhibit the migration and invasion of MKN45 gastric cancer cells. In contrast, up-regulation of coronin 3 significantly enhanced migration and invasion of MKN28-NM cells. In addition, knockdown of coronin 3 significantly reduced liver metastasis in mice after tail vein injection of gastric cancer cells. The Human Tumor Metastasis PCR Array was used to screen the metastasis-associated genes identified by the down-regulation of coronin 3, and the results suggested that, following the knockdown of coronin 3, the tumor cell migration and invasion were inhibited by the reduced expression of MMP-9 and cathepsin K.Coronin 3 is highly expressed in gastric cancer metastases and can promote the metastatic behaviors of gastric cancer cells, including their migration and invasion.
ABVD (8 cycles) versus BEACOPP (4 escalated cycles ≥4 baseline): final results in stage III–IV low-risk Hodgkin lymphoma (IPS 0–2) of the LYSA H34 randomized trial
Authors: N. Mounier, P. Brice, S. Bologna, J. Briere, I. Gaillard, M. Heczko, J. Gabarre, O. Casasnovas, J. Jaubert, P. Colin, A. Delmer, A. Devidas, E. Bachy, E. Nicolas-Virelizier, A. Aoudjhane, C. Humbrecht, M. Andre, P. Carde
Journal: Annals of Oncology (2014)