CLINICAL EVALUATION OF GITALIN IN THE TREATMENT OF CONGESTIVE HEART FAILURE
Authors: S P DIMITROFF, G C GRIFFITH, M C THORNER, J WALKER
Journal: Annals of Internal Medicine (1953)

Article1 December 1953CLINICAL EVALUATION OF GITALIN IN THE TREATMENT OF CONGESTIVE HEART FAILURESIM P. DIMITROFF, M.D., GEORGE C. GRIFFITH, M.D., M. C. THORNER, M.D., JOSEPH WALKER, M.D.SIM P. DIMITROFF, M.D., GEORGE C. GRIFFITH, M.D., M. C. THORNER, M.D., JOSEPH WALKER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-6-1189 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe cardiac glycoside, gitalin, was first isolated from Digitalis purpurea by Kraft 40 years ago.1 It has been used extensively in Europe, where some investigators believed it to be superior to other digitalis glycosides.2, 3 Studies reported from American clinics during 1934-1938 expressed only limited enthusiasm for its merits,4, 5, 6 and it was not accepted as standard therapy.Interest in the drug has recently been re-awakened by the introduction of an amorphous form of gitalin which was stable and uniform,7and which was found to equal other glycosides in its ability to induce adequate initial and maintenance digitalization.8In...Bibliography1. Kraft F: Die Glykoside der Blatter der Digitalis purpurea, Arch. d. Pharm. 250: 118, 1912. CrossrefGoogle Scholar2. StraubKrehl WL: Über Verodigen (Gitalin), Deutsche med. Wchnschr. 45: 281, 1919. CrossrefGoogle Scholar3. MansfeldHorn GZ: Untersuchungen über die Wirkungsweise des Gitalins, Arch. f. exper. Path. u. Pharmakol. 144: 46, 1929. CrossrefGoogle Scholar4. StroudLivingstonBromerVander VeerGriffith WDAEAWJBGC: The use of verodigen (a digitalis glucoside) in cardiovascular disease, its biological assay, and pharmacological action, Ann. Int. Med. 8: 710, 1934. LinkGoogle Scholar5. BakerBloom JPN: Clinical studies on verodigen, a digitalis glucoside, Ann. Int. Med. 10:605, 1936. LinkGoogle Scholar6. LevyBoas HEP: Clinical studies of gitalin and of digitalis in the treatment of auricular fibrillation, Am. Heart J. 15: 643, 1938. CrossrefGoogle Scholar7. BattermanDeGraffGutnerRossLhowe RCACLBOAJ: The comparative value of Gitaligin and other digitalis preparations, Federation Proc. 9: 256, 1950. Google Scholar8. BattermanDeGraffGutnerRoseLhowe RCACLBOAJ: Studies with gitalin (amorphous) for the treatment of patients with congestive heart failure, Am. Heart J. 42:292, 1951. CrossrefMedlineGoogle Scholar9. BattermanDeGraff RCAC: Comparative study on the use of the purified digitalis glycosides, Digoxin, digitoxin, and lanatoside C, for the management of ambulatory patients with congestive heart failure, Am. Heart J. 34: 663, 1947. CrossrefMedlineGoogle Scholar10. BattermanDeGraffRose RCACOA: The therapeutic range of gitalin (amorphous) compared with other digitalis preparations, Circulation 5: 201, 1952. CrossrefMedlineGoogle Scholar11. HejtmancikHerrmann MRGR: A clinical study of gitalin, Arch. Int. Med. 90: 224, 1952. CrossrefGoogle Scholar12. HaringLuisada OMAA: Studies with intravenous gitalin: I. Clinical and electrocardiographic observations, Am. Heart J. 45: 108, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 28, 1953.From the Department of Medicine (Cardiology), School of Medicine, University of Southern California, and the Los Angeles County Hospital, Los Angeles, California.†Gitalin was supplied by White Laboratories, Inc. It is commercially available under the trade name of Gitaligin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCurrent state and future perspective of cardiovascular medicines derived from natural products4 Approach to the Chemotopography of the Digitalis Recognition Matrix in Na+/K+-transporting ATPase as a Step in the Rational Design of New Inotropic SteroidsDigitalis assayGitalin studiesTherapie der HerzinsuffizienzThe treatment of heart failure and the use of digitalis in myocardial infarctionTherapeutic and Toxic Indexes of DigitalisDigitalis in Congestive Heart FailureThe Clinical Use of Digitalis PreparationsIndications for and Use of the Cardiac GlycosidesTHE ASCENDANCY OF DIGITOXIN AND RENAISSANCE OF GITALINH. J. L. MARRIOTT 1 December 1953Volume 39, Issue 6Page: 1189-1199KeywordsDrugsGlycosidesHeart failureHospital medicine ePublished: 1 December 2008 Issue Published: 1 December 1953 PDF downloadLoading ...