tbuckley/cabot-search huggingface dataset:
Restenosis After Delayed Coronary Angioplasty of the Culprit Vessel in Patients With a Recent Myocardial Infarction Treated by Thrombolysis
Authors: Christophe Bauters, Patrick Khanoyan, Eugène P. Mc Fadden, Philippe Quandalle, Jean-Marc Lablanche, Michel E. Bertrand
Journal: Circulation (1995)

Clinical follow-up after percutaneous transluminal coronary angioplasty (PTCA) of an infarct-related lesion has demonstrated a low incidence of recurrent symptoms and repeated revascularization. In the absence of systematic angiographic follow-up, this low rate of clinical restenosis may reflect either a truly lower incidence of anatomic restenosis or the lack of recurrent symptoms in patients with extensive infarction in the territory of the restenotic vessel.We studied 300 consecutive patients who, after a thrombolysis for myocardial infarction, underwent delayed (10.5 +/- 6 days after the myocardial infarction) PTCA of the infarct-related lesion. Procedural success was obtained in 253 patients (84%), and angiographic follow-up was performed in 205 of this group (81%) at a mean of 7.3 +/- 1.9 months. Restenosis (defined as the recurrence of > 50% stenosis) was present in 105 patients (51%). Only 34 of the 105 patients (32%) with angiographic restenosis were symptomatic; the other 68% had clinically silent restenosis. Of these 105 patients, 27 (13% of the total population undergoing follow-up angiography) had reocclusion at the dilated site at follow-up. The severity of the stenosis at follow-up and the late loss in minimal lumen diameter followed a nearly Gaussian distribution if the lesions that were totally occluded at follow-up were excluded. By multivariate analysis, two independent predictors of reocclusion were identified: a small reference diameter (P < .0005) and the presence of collateral vessels before the procedure (P < .01). Only one factor was associated with restenosis in the 178 patients who did not have reocclusion at follow-up; a Thrombolysis in Myocardial Infarction grade < or = 2 before the procedure (P < .0001). At follow-up, there was a significantly (P < .01) higher ejection fraction in patients without restenosis (56.1 +/- 13.4%) and in patients with restenosis without total occlusion (56.0 +/- 13.8%) than in patients with reocclusion (46.4 +/- 13.0%).Despite a satisfactory clinical outcome, delayed PTCA of an infarct-related lesion is associated with a high rate of angiographic recurrence. Two distinct mechanisms account for recurrent stenosis: progressive luminal renarrowing as documented after angioplasty of stable lesions and reocclusion of the infarct-related lesion. Only reocclusion is associated with a deterioration in left ventricular function at follow-up.
Combined thalidomide-radiation effect <i>in vitro</i> study
Authors: A. S. Glicksman, J. Leith
Journal: Journal of Clinical Oncology (2005)

9645 Background: The antiangiogenic and immunomodulatory effects of thalidomide have brought this agent into current cancer therapy. Since concurrent radiation may be a component of the therapeutic regimen, and only limited data is available about concurrent administration of radiation and thalidomide, we undertook to study the effects of x-ray irradiation and thalidomide on murine embryoid bodies (EB) as an in vitro model of vascular development. Methods: Murine stem cells were grown on a feeder cell layer of embryonic fibroblasts. EBs, produced by growing stem cells in spinner flasks, were exposed to thalidomide or 250 kVp x-rays, alone or in combination. This concentration of thalidomide and xray dose was estimated to be comparable to clinically relevant therapy. EB volume, clonogenic survival, vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), and tumor necrosis factor- α (TNF- α) were then measured. Results: Growth delay with thalidomide (100 ug/ml),) was similar to that of 2 Gy of x-rays. 100 mcg/ml Thal combined with 2 Gy of x-rays results were similar to 4 Gy of x-ray dose. Clonogenic survival curves from oxic and hypoxic EBs were exponential. Increased cell killing was seen when 100 ug/ml of Thal was added. X-ray at 2 or 4 Gy produced no change in VEGF, FGF-2, and TNF-α in EBs. However, Thal treatment 100 ug/ml, significantly decreased VEGF and TNF-α, but did not affect FGF-2. Conclusions: Thal treatment of EBs at 100mcg/ml is similar to 2 Gy of x-rays. However, there were differences in responses shown particularly by VEGF in EBs given Thal. The increased radiosensitization seen with Thal may therefore be related to decrease intracellular level of VEGF. Since radiation sensitization was greater in hypoxic cells than oxic cells, this might provide additional radiosensitization in hypoxic cells. Since Thal is an antiangiogenic agent its importance in vivo might include effects on antiangiogenesis remodeling and migration as well as on cell survival Accordingly in vivo studies are needed to determine Thal effects upon functional vasculature within the body of a solid tumor. No significant financial relationships to disclose.
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo
Authors: Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson, Jing Bao, Indranil Paul, Lars Egevad, Benedikt M Kessler, Pernilla Wikström, Yuanjie Niu, Amilcar Flores-Morales
Journal: Molecular Cancer (2015)

Ubiquitination is a highly dynamic and reversible process with a central role in cell homeostasis. Deregulation of several deubiquitinating enzymes has been linked to tumor development but their specific role in prostate cancer progression remains unexplored. RNAi screening was used to investigate the role of the ovarian tumor proteases (OTU) family of deubiquitinating enzymes on the proliferation and invasion capacity of prostate cancer cells. RhoA activity was measured in relation with OTUB1 effects on prostate cancer cell invasion. Tumor xenograft mouse model with stable OTUB1 knockdown was used to investigate OTUB1 influence in tumor growth. Our RNAi screening identified OTUB1 as an important regulator of prostate cancer cell invasion through the modulation of RhoA activation. The effect of OTUB1 on RhoA activation is important for androgen-induced repression of p53 expression in prostate cancer cells. In localized prostate cancer tumors OTUB1 was found overexpressed as compared to normal prostatic epithelial cells. Prostate cancer xenografts expressing reduced levels of OTUB1 exhibit reduced tumor growth and reduced metastatic dissemination in vivo. OTUB1 mediates prostate cancer cell invasion through RhoA activation and promotes tumorigenesis in vivo. Our results suggest that drugs targeting the catalytic activity of OTUB1 could potentially be used as therapeutics for metastatic prostate cancer.
Hippocampus Volume and Treatment Delays in First-Episode Schizophrenia
Authors: Beng-Choon Ho, Daniel Alicata, Carmencita Mola, Nancy C Andreasen
Journal: American Journal of Psychiatry (2005)

Many schizophrenia patients remain undiagnosed and untreated for long periods of time. It has been suggested that untreated psychosis may have deleterious neurotoxic effects. However, studies examining the correlates of untreated initial psychosis duration have been mixed. Previous MRI studies have reported no significant correlations between duration of untreated initial psychosis and brain volumes but have not examined specific brain regions that may be most susceptible to neuronal damage.The authors investigated the relationship between duration of untreated initial psychosis and hippocampus morphology in 105 patients with first-episode DSM-IV schizophrenia spectrum disorders. High-resolution MRI-based hippocampal volume measurements were obtained by using a semiautomated artificial neural network method.There were no significant associations between hippocampal volumes and duration of untreated initial psychosis. When the patient group was split around the median duration of untreated initial psychosis (13 weeks), there were again no significant differences in left, right, or total hippocampal volume between groups.These findings do not support the hypothesis that psychosis is neurotoxic or that delaying antipsychotic drug treatment results in reduced hippocampal volumes.
Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial
Authors: W Abdullah Brooks, Mathuram Santosham, Aliya Naheed, Doli Goswami, M Abdul Wahed, Marie Diener-West, Abu SG Faruque, Robert E Black
Journal: The Lancet (2005)
Hypersensitivity to influenza vaccine in a case of Epstein-Barr virus-associated T-lymphoproliferative disorder
Authors: Y. Himuro, F. Miyagawa, T. Fukumoto, T. Morii, M. Hasegawa, N. Kobayashi, H. Asada
Journal: British Journal of Dermatology (2015)

Journal Article Hypersensitivity to influenza vaccine in a case of Epstein–Barr virus‐associated T‐lymphoproliferative disorder Get access Y. Himuro, Y. Himuro Department of Dermatology Nara Medical University School of Medicine 840 Shijo‐cho Kashihara Nara 634‐8522 Japan Search for other works by this author on: Oxford Academic Google Scholar F. Miyagawa, F. Miyagawa Department of Dermatology Nara Medical University School of Medicine 840 Shijo‐cho Kashihara Nara 634‐8522 Japan Search for other works by this author on: Oxford Academic Google Scholar T. Fukumoto, T. Fukumoto Department of Dermatology Nara Medical University School of Medicine 840 Shijo‐cho Kashihara Nara 634‐8522 Japan Search for other works by this author on: Oxford Academic Google Scholar T. Morii, T. Morii Department of Hematology Nara Medical University School of Medicine 840 Shijo‐cho Kashihara Nara 634‐8522 Japan Search for other works by this author on: Oxford Academic Google Scholar M. Hasegawa, M. Hasegawa Department of Radiation Oncology Nara Medical University School of Medicine 840 Shijo‐cho Kashihara Nara 634‐8522 Japan Search for other works by this author on: Oxford Academic Google Scholar N. Kobayashi, N. Kobayashi Department of Dermatology Nara Medical University School of Medicine 840 Shijo‐cho Kashihara Nara 634‐8522 Japan Search for other works by this author on: Oxford Academic Google Scholar H. Asada H. Asada Department of Dermatology Nara Medical University School of Medicine 840 Shijo‐cho Kashihara Nara 634‐8522 Japan Correspondence: Hideo Asada. E‐mail: asadah@naramed-u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 6, 1 June 2015, Pages 1686–1688, https://doi.org/10.1111/bjd.13713 Published: 01 June 2015
Dose-dense rituximab-CHOP compared with standard rituximab-CHOP in elderly patients with diffuse large B-cell lymphoma (the LNH03-6B study): a randomised phase 3 trial
Authors: Richard Delarue, Hervé Tilly, Nicolas Mounier, Tony Petrella, Gilles Salles, Catherine Thieblemont, Serge Bologna, Hervé Ghesquières, Maya Hacini, Christophe Fruchart, Loïc Ysebaert, Christophe Fermé, Olivier Casasnovas, Achiel Van Hoof, Antoine Thyss, Alain Delmer, Olivier Fitoussi, Thierry Jo Molina, Corinne Haioun, André Bosly
Journal: The Lancet Oncology (2013)
Metabolic Effects of Exogenous Glucocorticoids in Fasted Man
Authors: O. E. Owen, G. F. Cahill
Journal: Journal of Clinical Investigation (1973)

The influence of administering excessive amounts of glucocorticoids on circulating substrates and hormones and on urinary excretion of nitrogenous compounds and ketone bodies was examined in man after prolonged starvation. After 35 days of total caloric deprivation the administration of high physiologic doses of glucocorticoids increased circulating glucose and insulin levels without intensifying total urinary nitrogen excretion. The increased blood glucose seemed to be due to diminished peripheral uptake rather than augmented gluconeogenesis. A small, transient increase in circulating plasma amino acids was observed. However, the secondary rise in serum insulin seemed to block the proteolytic effect(s) of glucocorticoids, preventing them from mobilizing body protein stores during starvation. There was no change in circulating free fatty acids or glycerol. Thus, it appeared that the potential catabolic action of excessive glucocorticoids was offset by the anabolic effect of insulin, and a new state of homeostasis was established.An additional effect of glucocorticoid administration was a marked diminution of renal excretion of ketone bodies.
Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor.
Authors: U de Grazia, M P Felli, A Vacca, A R Farina, M Maroder, L Cappabianca, D Meco, M Farina, I Screpanti, L Frati, A Gulino
Journal: The Journal of Experimental Medicine (1994)

The differentiating agent retinoic acid (RA) has been previously reported to interfere with 12-O-tetradecanoyl-phorbol-13-acetate (TPA)/Ca2+-induced signals for the regulation of the -96 to -66-bp octamer motif found in the enhancer for the interleukin (IL)-2 gene, which encodes a major T lymphocyte growth factor. The IL-2 octamer motif is a composite cis-element which binds Oct-1 and Oct-2 as well as a TPA/Ca2+-inducible nuclear factor, previously termed octamer-associated protein (OAP40). We show here that Oct-2, despite the presence of an active transcriptional activation domain, requires TPA/Ca2+-induced signals to strongly transactivate the IL-2 octamer motif in Jurkat T cells. This Oct-2-dependent transactivation is inhibited by RA. The presence of an intact COOH-terminal domain of Oct-2 contributes to both TPA/Ca2+-induced transactivation and the RA-mediated repression. We also show that both Fos and Jun components of the AP-1 factors participate in the OAP40 complex. Furthermore, transfected c-jun, jun-B, jun-D, c-fos, or Fos-B expression vectors partially substitute for TPA and Ca2+ and cooperate with Oct-2 for the transactivation of the combined OAP/octamer cis-element. Mutations of the genuine octamer-binding site abrogate both the binding of Oct-1 and Oct-2 and the TPA/Ca2+-induced transactivation of the OAP/octamer motif. OAP confers to Oct-2 responsivity to both TPA/Ca2+ and RA, since specific mutations of the AP-1/OAP-binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA. Furthermore, retinoic acid receptor (RAR) alpha is able to inhibit in vitro the formation of the complex between the nuclear AP-1/OAP and its specific binding site, resulting in the interference with Oct-2-dependent cis-regulatory function of this AP-1 element. Therefore, we propose that the TPA/calcium-activated AP-1/OAP element is the main target of positive or negative regulatory signals influencing the IL-2 octamer motif, through synergism with Oct-2 and antagonism by RAR.
NI-34 * BRAIN LOCATIONS INVOLVED IN COGNITIVE ALTERATIONS AFTER RESECTIVE BRAIN SURGERY IDENTIFIED BY RESECTION PROBABILITY MAPS
Authors: E. J. Hendriks, E. J. Habets, M. Klein, F. Barkhof, W. P. Vandertop, M. J. Taphoorn, P. C. d. W. Hamer
Journal: Neuro-Oncology (2014)

INTRODUCTION: Cognition is at risk in patients with brain tumors. Cognitive alterations, improvement or decline, may result from brain tumor surgery, as well as from other factors such as direct tumor effects, radiotherapy, chemotherapy, anti-epileptic drugs, and steroids. In this study, cognitive alterations after brain tumor surgery are quantified and correlated with brain location using resection probability maps, which is a new approach. METHODS: Adult patients were included, who had (1) a brain tumor, (2) resective surgery between 2006 and 2011, (3) baseline and postoperative (9-12 months) neuropsychological assessment in seven cognitive domains, and (4) pre- and postoperative MRI available. Resective surgery was performed with intraoperative stimulation mapping until functional boundaries were met. Resection probability maps quantify the likelihood of resection throughout the brain in 3D at 1 mm resolution in standard brain space. We compared resection probability maps of patients with and without cognitive alterations. Considerations for spatial dependence and multiple comparisons were taken into account. PRELIMINARY RESULTS: Seventy-four patients were so far included. The cognitive domains with most frequent and most extensive alterations after surgery were attentional function and working memory capacity. Results on the correlation between these cognitive changes and brain location are pending, but will be available in October 2014. CONCLUSION: Brain locations involved in cognitive improvement as well as decline in relation to resective surgery can be identified using resection probability maps. Brain tumors which are located in regions to be identified are associated with alterations in attention and verbal working memory.
Frederick Thomas Graves
Authors: R. Harris
Journal: BMJ (2003)

Former consultant general surgeon Staffordshire General Infirmary (b Hereford 1919; q University College London 1943; DSc, MS, FRCS), d 27 February 2003.

Fred started his surgical career at University College Hospital and later King's College Hospital, London, and began his research into the arterial anatomy of the kidney in 1952. He was Hunterian professor at the Royal College of Surgeons in 1956. He published 11 papers and four books, of which the most well known is The Arterial Anatomy of the Kidney (1971). His work laid the ground for many more recent developments and the partial nephrectomy became, and still is, a standard procedure. Predeceased by his wife, Mary, he leaves two children and four grandchildren.
The value of upper gastrointestinal endoscopy
Authors: R. R. Barb
Journal: JAMA (1973)

Upper gastrointestinal endoscopy is a valuable aid in the diagnosis of mucosal diseases involving the stomach and duodenum. Technical advances in the design of fiber optic equipment 1 combined with increasing physician experience in their use have led to a safe and accurate procedure that can be accomplished quickly with only minimal discomfort to the patient. Visualized lesions are accessible to biopsy, and can be documented for future reference with still or movie photography.  A series of recent articles shows the importance of endoscopy in the evaluation of patients with diverse gastrointestinal symptoms who have normal results from barium studies of the stomach and duodenum. This is a common problem in the everyday practice of medicine.  Schuman 2 reviewed the gastroscopic findings in 843 patients with persistent complaints and normal upper-gastrointestinal x-ray films. One hundred sixty-three, or 20%, were found to have mucosal diseases, including 59 patients with ulcers and
Temporal changes in UK birth order and the prevalence of atopy
Authors: S. Upchurch, J. M. Harris, P. Cullinan
Journal: Allergy (2010)

Many studies have reported an inverse association between birth order and the risk of respiratory allergic disease. In recent decades, the prevalence of atopy has increased alongside reductions in fertility rates.To quantitate how much of the increased prevalence of atopy, measured by skin prick test or specific IgE, can be attributed to temporal changes in family size in the United Kingdom.Through a systematic literature review (MEDLINE, 1965-2009), five studies of UK populations were identified and their data were included in the calculation of a summary odds ratio for the risk of atopy for each birth order. Information on changes in UK family sizes between 1960 and 2001 was obtained from Eurostat. On this basis, expected increases in the prevalence of atopy were calculated by weighting the proportion in each birth order category for 1960 and 2001 by the summary odds ratio for that category and then calculating the relative risk of atopy in 2001 compared with 1960.The pooled summary odds ratios for atopy were 0.90, 0.69 and 0.69 for those born second, third and fourth (or higher), respectively. The expected relative increase in the prevalence of atopy resulting from a change in family size between 1960 and 2001 was 3%.Despite the strong associations between birth order and atopy, reductions in family size in the last 40 years account for little of the increase in atopy.
Plasma Norepinephrine Predicts Survival and Incident Cardiovascular Events in Patients With End-Stage Renal Disease
Authors: Carmine Zoccali, Francesca Mallamaci, Saverio Parlongo, Sebastiano Cutrupi, Francesco Antonio Benedetto, Giovanni Tripepi, Graziella Bonanno, Francesco Rapisarda, Pasquale Fatuzzo, Giuseppe Seminara, Alessandro Cataliotti, Benedetta Stancanelli, Lorenzo Salvatore Malatino
Journal: Circulation (2002)

Background — Sympathetic tone is consistently raised in patients with end-stage renal disease (ESRD). We therefore tested the hypothesis that sympathetic activation is associated with mortality and cardiovascular events in a cohort of 228 patients undergoing chronic hemodialysis who did not have congestive heart failure at baseline and who had left ventricular ejection fraction &gt;35%. Methods and Results — The plasma concentration of norepinephrine (NE) was used as a measure of sympathetic activity. Plasma NE exceeded the upper limit of the normal range (cutoff 3.54 nmol/L) in 102 dialysis patients (45%). In a multivariate Cox regression model that included all univariate predictors of death as well as the use of sympathicoplegic agents and β-blockers, plasma NE proved to be an independent predictor of this outcome (hazard ratio [1-nmol/L increase in plasma NE]: 1.07, 95% CI 1.01 to 1.14, P =0.03). Similarly, plasma NE emerged as an independent predictor of fatal and nonfatal cardiovascular events (hazard ratio [1-nmol/L increase in plasma NE] 1.08, 95% CI 1.02 to 1.15, P =0.01) in a model that included previous cardiovascular events, pulse pressure, age, diabetes, smoking, and use of sympathicoplegic agents and β-blockers. The adjusted relative risk for cardiovascular complications in patients with plasma NE &gt;75th percentile was 1.92 (95% CI 1.20 to 3.07) times higher than in those below this threshold ( P =0.006). Conclusions — Sympathetic nerve overactivity is associated with mortality and cardiovascular outcomes in ESRD. Controlled trials with antiadrenergic drugs are needed to determine whether interference with the sympathetic system could reduce the high cardiovascular morbidity and mortality in dialysis patients.
The additive value of tirofiban administered with the high-dose bolus in the prevention of ischemic complications during high-risk coronary angioplasty
Authors: Marco Valgimigli, Gianfranco Percoco, Dario Barbieri, Fabrizio Ferrari, Gabriele Guardigli, Giovanni Parrinello, Olga Soukhomovskaia, Roberto Ferrari
Journal: Journal of the American College of Cardiology (2004)