NEUTROPENIA IN A PATIENT TREATED WITH A MERCURIAL DIURETIC AND ITS RESPONSE TO BAL
Authors: C E BENDER, R J HOXSEY, Q B DeMARSH
Journal: Annals of Internal Medicine (1950)

Case Reports1 November 1950NEUTROPENIA IN A PATIENT TREATED WITH A MERCURIAL DIURETIC AND ITS RESPONSE TO BALCHARLES E. BENDER, M.D., ROBERT J. HOXSEY, M.D., QUIN B. DEMARSH, M.D.CHARLES E. BENDER, M.D.Search for more papers by this author, ROBERT J. HOXSEY, M.D.Search for more papers by this author, QUIN B. DEMARSH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-5-1285 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA review of the causes of agranulocytosis and the neutropenic states has revealed no case in which an organic mercurial diuretic was suspected as the etiologic agent.In the case being reported, a 61 year old white woman, a known hypertensive for six years, was given Mercupurin 2 c.c. intravenously three times weekly for 38 weeks, followed by the same dose daily for 14 days. On admission the white blood count was 1,000 per cu. mm., the differential showed polymorphonuclears 5, lymphocytes 57, monocytes 30, eosinophil 1, basophils 3, unclassified 4. A course of BAL was administered, and a count...Bibliography1. Kracke RR: Relation of drug therapy to neutropenic states, J. A. M. A. 111: 1255-1259, 1938. CrossrefGoogle Scholar2. FagetErickson GHPT: Discussion by Johnson, H. M.: Chemotherapy of leprosy, J. A. M. A. 136: 451-457, 1948. CrossrefGoogle Scholar3. DeGraffNadler ACJE: A review of the toxic manifestations of mercurial diuretics in man, J. A. M. A. 119: 1006-1011, 1942. CrossrefGoogle Scholar4. Ben-Asher S: On the toxicity of mercurial diuretics, Ann. Int. Med. 25: 711-724, 1946. LinkGoogle Scholar5. BarkerLindbergThomas MHHAME: Sudden death and mercurial diuretics, J. A. M. A. 119: 1001-1004, 1942. CrossrefGoogle Scholar6. Stealy CL: Chronic granulocytopenia of five years' duration with recurrent acute attacks, Am. J. M. Sc. 189: 633-638, 1935. CrossrefGoogle Scholar7. StephensLawrence DJJS: Cyclic agranulocytic angina, Ann. Int. Med. 9: 31-37, 1935. LinkGoogle Scholar8. CantorScott MMJW: Agranulocytic angina effectively treated with intravenous pyridoxine, Canad. M. A. J. 52: 368-371, 1947. Google Scholar9. Moore FD Discussion by Paschkis, K. E.: Toxic manifestations of thiouracil therapy, J. A. M. A. 130: 315-319, 1946. CrossrefMedlineGoogle Scholar10. LongFarrar WKA: The influence of certain sulfhydryl compounds on the toxicity of an organic mercurial diuretic, J. Pharmacol. and Exper. Therap. 88: 388-399, 1946. MedlineGoogle Scholar11. Editorial: BAL in treatment of arsenic and mercury poisoning, Ann. Int. Med. 25: 986-989, 1946. LinkGoogle Scholar12. : BAL in treatment of arsenic and mercury poisoning, J. A. M. A. 131: 824, 1946. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington*Received for publication July 15, 1948.From the Department of Medicine, University of Washington School of Medicine and King County Hospital, Seattle, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHuman exposure to mercury and its hematological effects: a systematic reviewImmune Mediated Neutropenia in Man and Animals: A ReviewQuecksilberhaltige DiureticaRenal Tubular Necrosis due to Nephrotoxicity of Organic Mercurial DiureticsRICHARD B. FREEMAN, M.D., JOHN F. MAHER, M.D., GEORGE E. SCHREINER, M.D., F.A.C.P., F. K. MOSTOFI, M.D.Therapie der HerzinsuffizienzVALUE OF AMINOPYRINE*†LEONARD CARDON, M.D., F.A.C.P., OSCAR H. COMESS, M.D., THOMAS A. NOBLE, M.D., MARK M. POMARANC, M.D.Immunologic agranulocytosis due to mercurial diureticsMetalleMetalleNewer Preparations of Mercurial Diuretics in Congestive Heart Failure 1 November 1950Volume 33, Issue 5Page: 1285-1290KeywordsBasophilsBlood countsBronchoalveolar lavageDiureticsEosinophilsHospital medicineLymphocytesMonocytesNeutropenia ePublished: 1 December 2008 Issue Published: 1 November 1950 PDF downloadLoading ...