tbuckley/cabot-search huggingface dataset:
Identification of a Novel Point Mutation in the<i>LEMD3</i>Gene in an Infant With Buschke-Ollendorff Syndrome
Authors: Johanna Kratzsch, Diana Mitter, Mirjana Ziemer, Jürgen Kohlhase, Harald Voth
Journal: JAMA Dermatology (2016)

Positive criteria found in almost all reported cases include (1) nodules or plaque lesions, (2) systemic symptoms such as fever and malaise, (3) histologic evidence of a subcutaneous lobular neutrophilic infiltrate, (4) association with myelodysplasia, and (5) sensitivity to systemic corticosteroids. 2,3Although SSS is distinct from classic Sweet syndrome, patients may present with a mix of both classic and subcutaneous lesions, and it is likely that these exist along a spectrum.Classic Sweet syndrome can appear prior to or concurrent with development of hematologic malignancy and often responds to dapsone (neutrophilinhibiting agent) and anti-tumor necrosis factor (anti-TNF) agents. 1 This patient's disease relapsed at doses of oral prednisone below 20 mg/d and did not respond to dapsone.To our knowledge, we have described the first case of SSS treated with adalimumab, an agent with proposed and documented benefit in autoimmune dermatologic diseases refractory to traditional agents. 4,5The patient demonstrated lasting disease remission with adalimumab monotherapy, providing evidence for use of this agent in treating SSS.Although case studies have suggested a potentially increased incidence of lymphoma in patients with rheumatoid arthritis treated with adalimumab, large cohort studies have not reproduced this finding. 6Interestingly, while anti-TNF agents have proven helpful in a variety of inflammatory and autoimmune disorders, rarely, treatment with these agents can lead to paradoxical development of autoimmune phenomena, though it was well tolerated in this patient.Adalimumab offers a new approach for patients with debilitating disease refractory to lower-dose corticosteroid therapy or traditional steroid-sparing agents.
Mutations in SIX2 and BMP4 are associated with anomlous development of the kidney in humans and zebafish
Authors: S Weber, J Taylor, Pjd Winyard, KF Baker, R Schild, T Knuppel, AM Zurowska, AC Caldas-Alfonso, M Litwin, S Emre, GM Ghiggeri, A Bakkaloglu, O Mehls, C Antignac, F Schaefer, RD Burdine
Journal: Journal of the American Society of Nephrology (2007)
Malignant Tumors in Rats Fed Nafenopin, a Hepatic Peroxisome Proliferator 2
Authors: J. K. Reddy, M. S. Rao
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Malignant Tumors in Rats Fed Nafenopin, a Hepatic Peroxisome Proliferator Get access J. K. Reddy, J. K. Reddy Search for other works by this author on: Oxford Academic PubMed Google Scholar M. S. Rao M. S. Rao Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 59, Issue 6, December 1977, Pages 1645–1650, https://doi.org/10.1093/jnci/59.6.1645 Published: 01 December 1977 Article history Received: 21 March 1977 Accepted: 30 June 1977 Published: 01 December 1977
Synthesis of Immunoglobulin and Marek's Disease Virus Antibody in Susceptible and Relatively Resistant Chickens 2
Authors: V. Kermani-Arab, T. Moll, W. C. Davis
Journal: JNCI Journal of the National Cancer Institute (1976)

The levels of IgM, IgY, and IgA and the development of specific antibody to Marek's disease virus (MDV) and sheep red blood cells (SRBC) in young chickens susceptible and resistant to Marek's disease were compared after exposure to MDV. No significant difference was noted in the immunoglobulin levels. However, the antibody response to MDV and SRBC occurred more rapidly in susceptible birds. The initial titer of antibody to these antigens was higher. These differences in response, however, were transient. At 3 weeks post exposure, the levels of IgM antibodies to MDV and antibodies to SRBC were similar in the two lines of chickens. At 6 weeks, the levels of IgY antibodies to MDV and antibodies detected by the agar gel precipitation test were similar.
VOODOO, BLACK MAGIC, AND THE HAWAIIAN KAHUNA
Authors: M L JANOWER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12172: HDL Cholesterol and the Risk of Microvascular Disease of Type 2 Diabetes
Authors: Jamie Morton, Sophia Zoungas, Qiang Li, Anushka A Patel, John Chalmers, Mark Woodward, David S Celermajer, Joline W Beulens, Ronald P Stolk, Paul Glasziou, Martin K Ng
Journal: Circulation (2012)
Tumour-associated and non-tumour-associated microbiota in colorectal cancer
Authors: Burkhardt Flemer, Denise B Lynch, Jillian M R Brown, Ian B Jeffery, Feargal J Ryan, Marcus J Claesson, Micheal O'Riordain, Fergus Shanahan, Paul W O'Toole
Journal: Gut (2016)

<h3>Objective</h3> A signature that unifies the colorectal cancer (CRC) microbiota across multiple studies has not been identified. In addition to methodological variance, heterogeneity may be caused by both microbial and host response differences, which was addressed in this study. <h3>Design</h3> We prospectively studied the colonic microbiota and the expression of specific host response genes using faecal and mucosal samples ('ON' and 'OFF' the tumour, proximal and distal) from 59 patients undergoing surgery for CRC, 21 individuals with polyps and 56 healthy controls. Microbiota composition was determined by 16S rRNA amplicon sequencing; expression of host genes involved in CRC progression and immune response was quantified by real-time quantitative PCR. <h3>Results</h3> The microbiota of patients with CRC differed from that of controls, but alterations were not restricted to the cancerous tissue. Differences between distal and proximal cancers were detected and faecal microbiota only partially reflected mucosal microbiota in CRC. Patients with CRC can be stratified based on higher level structures of mucosal-associated bacterial co-abundance groups (CAGs) that resemble the previously formulated concept of enterotypes. Of these, Bacteroidetes Cluster 1 and Firmicutes Cluster 1 were in decreased abundance in CRC mucosa, whereas Bacteroidetes Cluster 2, Firmicutes Cluster 2, Pathogen Cluster and Prevotella Cluster showed increased abundance in CRC mucosa. CRC-associated CAGs were differentially correlated with the expression of host immunoinflammatory response genes. <h3>Conclusions</h3> CRC-associated microbiota profiles differ from those in healthy subjects and are linked with distinct mucosal gene-expression profiles. Compositional alterations in the microbiota are not restricted to cancerous tissue and differ between distal and proximal cancers.
Long-Term Safety Follow-up of a Randomized Trial of Darbepoetin Alpha and Intravenous Iron Following Autologous Hematopoietic Cell Transplantation
Authors: Aurélie Jaspers, Frederic Baron, Johan Maertens, Bernard J. M. De Prijck, Henri (Rik) Schots, Christophe Bonnet, Kaoutar Hafraoui, Evelyne Willems, Sophie Servais, Georges Fillet, Yves Beguin
Journal: Blood (2014)
Tumor-Associated Antigens in Human Myeloma2
Authors: Robert G. Krueger, Linda D. Staneck, Jeanne M. Boehlecke
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Tumor-Associated Antigens in Human Myeloma Get access Robert G. Krueger, Robert G. Krueger Search for other works by this author on: Oxford Academic PubMed Google Scholar Linda D. Staneck, Linda D. Staneck Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeanne M. Boehlecke Jeanne M. Boehlecke Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 56, Issue 4, April 1976, Pages 711–715, https://doi.org/10.1093/jnci/56.4.711 Published: 01 April 1976 Article history Received: 23 June 1975 Accepted: 03 November 1975 Published: 01 April 1976
The &lt;italic&gt;In Vitro&lt;/italic&gt; Transformation by an Avian Adenovirus (CELO). III. Human Amnion Cell Cultures&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Jeffrey Anderson, Vance J. Yates, V. Jasty, Lawrence O. Mancini
Journal: JNCI Journal of the National Cancer Institute (1969)

This study has shown that chicken-embryo-lethal-orphan virus (CELO), an avian adenovirus, can transform human amnion cells. Cellular changes were evident 21 days after infection, when areas of rapidly proliferating pleomorphic cells were observed. Three continuous lines were isolated which consisted mainly of spindle-shaped cells. All lines contained the CELO-specific “T” antigen. Inoculations of hamsters with 1–6.5 × 106 cells in the cheek pouch produced rapidly growing fibrosarcomas.
Randomized, Phase II Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019) in Patients with Relapsed, Refractory CLL
Authors: David L. Porter, Noelle V. Frey, J. Joseph Melenhorst, Wei-Ting Hwang, Simon F. Lacey, Pamela Shaw, Anne Chew, Stephan A. Grupp, James Capobianchi, Joan Gilmore, Michael Kalos, Manuel Litchman, Lester Lledo, Alison Wakoff Loren, Yolanda Mahnke, Katherine T. Marcucci, Holly McConville, Angela Shen, Patricia A. Wood, Zhaohui Zheng, Bruce L. Levine, Carl H. June
Journal: Blood (2014)
Brief Communication: Electron Microscope Study on Human Lymphocyte—Sheep Erythrocyte Rosettes 2
Authors: K. Kataoka, J. Minowada, D. Pressman
Journal: JNCI Journal of the National Cancer Institute (1975)

Nonimmune rosette formation of human peripheral blood lymphocytes and cultered MOLT 3 and MOLT 4 cells with sheep red blood cells was studied by transmission electron microscopy. At the cell contact area of the rosette, lymphoid and red cell membranes were parallel and 80-100 A apart. The inner leaflet of the lymphoid cell membrane seemed denser, and amorphous substance attached to its cytoplasmic face. The cell contact area was 100-1000 nm wide and frequently on the lymphoiid cell body rather than on microvilli, though some cells extended microvilli near red cells.
Kupffer Cell Sarcoma in Rats After Exposure to Small Doses of Dimethylnitrosamine and &lt;italic&gt;N&lt;/italic&gt;-2-Acetylaminofluorene During Hepatic Regeneration
Authors: P Chopra, A Manga, N C Nayak
Journal: JNCI Journal of the National Cancer Institute (1979)

During experiments to study the evolution of hepatocellular carcinoma in adult male Wistar rats by exposing regenerating livers to the action of small doses of dimethylnitrosamine (DMN) or N-2-acetylaminofluorene (AAF), several primary sarcomas of the liver were incidentally observed. The morphology and behavior of the tumors suggest their origin from Kupffer's cells. Kupffer cell sarcomas occurred more frequently when 70% hepatectomy was used as the regenerative stimulus. None of the 36 animals treated with AAF alone and 2 of the 38 rats given DMN only had this tumor.
James Richard Young
Authors: Lauren Young
Journal: BMJ (2015)

James Richard Young (“Rick”) was born in Kuala Lumpur, Malaysia, and spent his childhood growing up in Penang. His interest in medicine and surgery began as a small child and was unstoppable. His father, Cheang Keng Young, general surgeon of Malaysia, had helped him, at the age of 7, to build a stool to stand on in theatre to watch operations. Rick …
Conversations for providers caring for patients with rectal cancer: Comparison of long‐term patient‐centered outcomes for patients with low rectal cancer facing ostomy or sphincter‐sparing surgery
Authors: Lisa J. Herrinton, Andrea Altschuler, Carmit K. McMullen, Joanna E. Bulkley, Mark C. Hornbrook, Virginia Sun, Christopher S. Wendel, Marcia Grant, Carol M. Baldwin, Wendy Demark‐Wahnefried, Larissa K. F. Temple, Robert S. Krouse
Journal: CA A Cancer Journal for Clinicians (2016)

For some patients with low rectal cancer, ostomy (with elimination into a pouch) may be the only realistic surgical option. However, some patients have a choice between ostomy and sphincter‐sparing surgery. Sphincter‐sparing surgery has been preferred over ostomy because it offers preservation of normal bowel function. However, this surgery can cause incontinence and bowel dysfunction. Increasingly, it has become evident that certain patients who are eligible for sphincter‐sparing surgery may not be well served by the surgery, and construction of an ostomy may be better. No validated assessment tool or decision aid has been published to help newly diagnosed patients decide between the two surgeries or to help physicians elicit long‐term surgical outcomes. Furthermore, comparison of long‐term outcomes and late effects after the two surgeries has not been synthesized. Therefore, this systematic review summarizes controlled studies that compared long‐term survivorship outcomes between these two surgical groups. The goals are: 1) to improve understanding and shared decision‐making among surgeons, oncologists, primary care providers, patients, and caregivers; 2) to increase the patient's participation in the decision; 3) to alert the primary care provider to patient challenges that could be addressed by provider attention and intervention; and 4) ultimately, to improve patients' long‐term quality of life. This report includes discussion points for health care providers to use with their patients during initial discussions of ostomy and sphincter‐sparing surgery as well as questions to ask during follow‐up examinations to ascertain any long‐term challenges facing the patient. CA Cancer J Clin 2016;66:387–397. © 2016 American Cancer Society.
P0709 : Survival of patients infected by chronic hepatitis c and f0f1 fibrosis at baseline after a 15 years follow-up
Authors: C. Jézéquel, E. Bardou-Jacquet, Y. Desille, I. Renard, F. Lainé, C. Lelan, M. Latournerie, A. Guillygomarch, P. Houssel-Debry, R. Moirand, Y. Deugnier, D. Guyader
Journal: Journal of Hepatology (2015)
Abstracts 1030–1231
Journal: Hepatology (2010)

We have previously reported that levels of large and buoyant hepatitis C virus particles surge in a very-low density fraction (VLDF, d<1.025 g/ml) of density gradients over a six hour time course after patients with chronic hepatitis C infection consume a high-fat meal.HCV particles in the VLDF (HCV-VLDF) were found to be associated with not only hepatically derived VLDL,
THU0595 Physical Activity and Rheumatoid Arthritis, A Systematic Review
Authors: F. Verhoeven, N. Tordi, C. Prati, C. Demougeot, F. Mougin, D. Wendling
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid Arthritis (RA) is the most common chronic inflammatory Rheumatism characterized by increased cardiovascular risk. In the general population, WHO proposes specific recommendations on the type of physical activity (PA) to achieve in the context of this cardiovascular risk. In RA patient, the place of PA is not highlighted to take care of the cardiovascular risk. <h3>Objectives</h3> The aim of this work is to provide the available data about the effects of the PA in RA <h3>Methods</h3> Systematic review of the literature on PubMed database with the following keywords: "physical activity", "motor activity", "Physical exercise" and "Rheumatoid arthritis". We focused to the studies in humans older than 18 years old and written in English. We identified 401 references, 256 were preselected and 49 were relevant for the analysis. <h3>Results</h3> RA is responsible for a greater inactivity highlighted with subjective measures (questionnaire) and with objective measures as the total energy expenditure or the accelerometer. Physical activity (PA) reduces significantly cardiovascular risk and DAS28. Physical inactivity and disease activity are correlated (RR 1.65 of inactivity as DAS28&gt;5.1). At the vascular level, it improves endothelial function (improve antioxidant mechanisms and increase eNOS activity) and slows atherosclerosis. At the bone level, it slows radiographic progression of small joints but worsens the radiographic damages of big joints. PA slows bone mineral density loss at the femoral neck (0% of median change of hip bone mineral density versus 1% in the control group after 1 year, p&lt;0.05) but have no effects on the spine. Finally, the practice of PA enhances quality of life (measured with the World Health Organization Quality of Life brief form) and decreases the perception of pain (VAS). The suggested type of PA is mainly an endurance activity. The majority of interventions are limited in time (4 weeks) with aerobic activities (running, cycling) 60 minutes, 5 days a week. Resistance activity programs also show an improvement in inflammation and muscle strength. Obstacles to the practice of AP are linked either to the patient with a lack of motivation and information, or to practitioners who have limited knowledge of the beneficial effects of the PA and its feasibility. Thus promotion of the PA in RA is very restricted (28% of patients). The solutions are many. At the patient level, one would improve their information on the beneficial effects of the PA. At the practitioner level, one should promote more systematically the PA. Finally, the supervised character of the PA like the monitoring program on internet would increase compliance <h3>Conclusions</h3> The beneficial effects of PA on RA are multiple and its practice should be promoted as part of the patients therapeutic education. <h3>Disclosure of Interest</h3> None declared
Abstract 13688: Non-Alcoholic Fatty Liver Disease is an Independent Predictor of Long-Term Incident Coronary Heart Disease Events-The Multi-Ethnic Study of Atherosclerosis
Authors: Irfan Zeb, Matthew Budoff, Ronit Katz, Donald Lloyd-Jones, Arthur Agatston, Roger S Blumenthal, Michael Blaha, Ron Blankstein, J Jeffery Carr, Khurram Nasir
Journal: Circulation (2012)

Background: There is significant overlap between risk factors for atherosclerosis and non-alcoholic fatty liver disease (NAFLD), and studies have shown an independent association between markers of...
Parkinson's disease, depression, and ECT: a review and case study
Authors: G Asnis
Journal: American Journal of Psychiatry (1977)

The author reviews the association between Parkinson's disease and depression and presents evidence to support the hypothesis that depression may be not only reactive but biochemically related to the disease. A psychotically depressed patient with parkinsonism responded positively to ECT as shown by improvement on a depression rating scale, two extrapyramidal rating scales, and handwriting samples. The beneficial effect on parkinsonian signs occurred before the improvement in depression, which suggests that ECT has a specific antiparkinsonian effect. Possible explanations for this observation based on biochemical theories of depression are discussed.
Autologous stem cell transplantation in first complete remission may not extend progression-free survival in patients with peripheral T cell lymphomas
Authors: Clinton Yam, Daniel J. Landsburg, Kevin T. Nead, Xinyi Lin, Anthony R. Mato, Jakub Svoboda, Alison W. Loren, Noelle V. Frey, Edward A. Stadtmauer, David L. Porter, Stephen J. Schuster, Sunita D. Nasta
Journal: American Journal of Hematology (2016)

Patients with peripheral T cell lymphomas (PTCL) generally have a poor prognosis when treated with conventional chemotherapy. Consolidation with autologous stem cell transplantation (ASCT) has been reported to improve progression-free survival. However, these studies have not compared consolidative ASCT with active observation in patients with PTCL achieving first complete remission (CR1) following induction chemotherapy. We conducted a retrospective analysis of PTCL patients treated at the University of Pennsylvania between 1/1/2007 and 12/31/2014. Patients with cutaneous T cell lymphoma, concurrent B cell lymphomas, and anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK-positive ALCL) were excluded from the study. We compared progression-free survival for patients who underwent ASCT in CR1 following CHOP-like induction regimens and patients who underwent active observation during CR1. 48 patients met all inclusion and exclusion criteria and underwent either active observation (28 patients) or consolidative ASCT (20 patients) in CR1. The 1-year cumulative incidence of relapse in the observation and ASCT groups was 50% (95% confidence interval [CI]: 30-67%) and 46% (95% CI: 23-67%), respectively (P = 0.55). Median progression-free survival in the observation and ASCT groups was 15.8 and 12.8 months, respectively (log rank, P = 0.79). Estimated 3-year progression-free survival in the observation and ASCT groups was 37 and 41%, respectively. In conclusion, for PTCL patients achieving CR1 following CHOP-like induction chemotherapy, ASCT does not appear to improve progression-free survival compared to active observation. This finding should be confirmed in a larger, prospective study. Am. J. Hematol. 91:672-676, 2016. © 2016 Wiley Periodicals, Inc.
Fracture epidemiology in male elite football players from 2001 to 2013: ‘How long will this fracture keep me out?’
Authors: David Larsson, Jan Ekstrand, Magnus K Karlsson
Journal: British Journal of Sports Medicine (2016)

Determining fracture risk and rehabilitation periods after specific fractures in professional football is essential for team planning.To identify fracture epidemiology and absences after different types of fractures in male professional football players.2439 players from 41 professional male teams in 10 countries were followed prospectively from 2001 to 2013. Team medical staff registered fractures, absences after fractures and player exposure.364 fractures were recorded, with an incidence of 0.27/1000 h of exposure (95% CI 0.25 to 0.30). The incidence of traumatic fractures was 0.25 (0.22 to 0.27) and that of stress fractures was 0.03 (0.02 to 0.04). 45% of traumatic fractures and 86% of stress fractures affected the lower extremities. Absence after a fracture was 32 days (1-278) (median (range)), compared to that after a traumatic fracture of 30 days (1-278) and a stress fracture of 65 days (6-168) (p<0.001). Annual fracture incidence was stable during the study period (R(2)=0.051, b=-0.011 (95% CI -0.043 to 0.021)). Young players had a relative risk of 10.9 (3.3 to 35.6) of sustaining stress fractures compared to old players (p<0.01). The fracture incidence did not differ between individuals in different playing positions (p=0.10).A male professional football team can expect 1 to 2 fractures per season. There are more traumatic fractures than stress fractures; while most fractures affect the lower extremities, stress fractures yield longer absences than traumatic fractures and young players have more stress fractures than old players. There is no difference in risk among players at different playing positions.