tbuckley/cabot-search huggingface dataset:
Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study
Authors: Ashley F. Stein-Merlob, Chase W. Kessinger, S. Sibel Erdem, Henry Zelada, Scott A. Hilderbrand, Charles P. Lin, Guillermo J. Tearney, Michael R. Jaff, Guy L. Reed, Peter K. Henke, Jason R. McCarthy, Farouc A. Jaffer
Journal: Theranostics (2015)

Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy.In particular, it is unknown how age-dependent thrombus organization limits direct blood contact with fibrin, the target of blood-based fibrinolytic agents.Utilizing high-resolution in vivo optical molecular imaging with FTP11, a near-infrared fluorescence (NIRF) fibrin-specific reporter, here we investigated the in vivo interrelationships of blood accessibility to fibrin, thrombus age, thrombus neoendothelialization, and fibrinolysis in murine venous thrombosis (VT).In both stasis VT and non-stasis VT, NIRF microscopy showed that FTP11 fibrin binding was thrombus age-dependent.FTP11 localized to the luminal surface of early-stage VT, but only minimally to subacute VT (p<0.001).Transmission electron microscopy of early stage VT revealed direct blood cell contact with luminal fibrin-rich surfaces.In contrast, subacute VT exhibited an encasing CD31+ neoendothelial layer that limited blood cell contact with thrombus fibrin in both VT models.Next we developed a theranostic strategy to predict fibrinolytic efficacy based on the in vivo fibrin accessibility to blood NIRF signal.Mice with variably aged VT underwent FTP11 injection and intravital microscopy (IVM), followed by tissue plasminogen activator infusion to induce VT fibrinolysis.Fibrin molecular IVM revealed that early stage VT, but not subacute VT, bound FTP11 (p<0.05), and experienced higher rates of fibrinolysis and total fibrinolysis (p<0.05 vs. subacute VT).Before fibrinolysis, the baseline FTP11 NIRF signal predicted the net fibrinolysis at 60 minutes (p<0.001).Taken together, these data provide novel insights into the temporal evolution of VT and its susceptibility to therapeutic fibrinolysis.Fibrin molecular imaging may provide a theranostic strategy to identify venous thrombi amenable to fibrinolytic therapies.
Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy
Authors: M. Cecilia Caino, Dario C. Altieri
Journal: Clinical Cancer Research (2015)

Small-molecule inhibitors of the phosphoinositide 3-kinase (PI3K), Akt, and mTOR pathway currently in the clinic produce a paradoxical reactivation of the pathway they are intended to suppress. Furthermore, fresh experimental evidence with PI3K antagonists in melanoma, glioblastoma, and prostate cancer shows that mitochondrial metabolism drives an elaborate process of tumor adaptation culminating with drug resistance and metastatic competency. This is centered on reprogramming of mitochondrial functions to promote improved cell survival and to fuel the machinery of cell motility and invasion. Key players in these responses are molecular chaperones of the Hsp90 family compartmentalized in mitochondria, which suppress apoptosis via phosphorylation of the pore component, Cyclophilin D, and enable the subcellular repositioning of active mitochondria to membrane protrusions implicated in cell motility. An inhibitor of mitochondrial Hsp90s in preclinical development (gamitrinib) prevents adaptive mitochondrial reprogramming and shows potent antitumor activity in vitro and in vivo. Other therapeutic strategies to target mitochondria for cancer therapy include small-molecule inhibitors of mutant isocitrate dehydrogenase (IDH) IDH1 (AG-120) and IDH2 (AG-221), which opened new therapeutic prospects for patients with high-risk acute myelogenous leukemia (AML). A second approach of mitochondrial therapeutics focuses on agents that elevate toxic ROS levels from a leaky electron transport chain; nevertheless, the clinical experience with these compounds, including a quinone derivative, ARQ 501, and a copper chelator, elesclomol (STA-4783) is limited. In light of this evidence, we discuss how best to target a resurgence of mitochondrial bioenergetics for cancer therapy.
Patterns of Needlestick and Sharps Injuries Among Training Residents
Authors: Thomas Marnejon, David Gemmel, Kelli Mulhern
Journal: JAMA Internal Medicine (2015)

Joshua J. Fenton, MD, MPH; Richard L. Kravitz, MD, MSPH; Anthony Jerant, MD; Debora A. Paterniti, PhD; Heejung Bang, PhD; Donna Williams, MD; Ronald M. Epstein, MD; Peter Franks, MD
Impact of Lesion Placement on Efficacy and Safety of Catheter-Based Radiofrequency Renal Denervation
Authors: Felix Mahfoud, Stefan Tunev, Sebastian Ewen, Bodo Cremers, Jennifer Ruwart, Daniel Schulz-Jander, Dominik Linz, Justin Davies, David E. Kandzari, Robert Whitbourn, Michael Böhm, Robert J. Melder
Journal: Journal of the American College of Cardiology (2015)

Insufficient procedural efficacy has been proposed to explain nonresponse to renal denervation (RDN). The aim of this study was to examine the impact of different patterns of lesion placements on the efficacy and consistency of catheter-based radiofrequency RDN in pigs. The impact of increasing number of lesions versus location of RDN was investigated in a porcine model (Group 1; n = 51). The effect of treating the main artery, the branches, and the 2 combined was compared in Group 2 (n = 48). The durability of response and safety of combined treatment of the main artery plus branches was examined in Group 3 (n = 16). Renal norepinephrine (NE) tissue content and renal cortical axon density were assessed. Increasing the number of RF lesions (4, 8, and 12) in the main renal artery was not sufficient to yield a clear dose-response relationship on NE content and axon density. In contrast, targeted treatment of the renal artery branches or distal segment of the main renal artery resulted in markedly less variability of response and significantly greater reduction of both NE and axon density than conventional treatment of only the main renal artery. Combination treatment (main artery plus branches) produced the greatest change in renal NE and axon density with the least heterogeneity. The changes were durable through 28 days post-treatment. These data provide the rationale for investigation of an optimized approach for RDN in future clinical studies. This may have profound implications for the clinical application of RDN, as this approach may not only achieve greater reductions in sympathetic activity but also reduce treatment effect variability.
Tamoxifen and Antidepressant Drug Interaction in a Cohort of 16 887 Breast Cancer Survivors
Authors: Reina Haque, Jiaxiao Shi, Joanne E. Schottinger, Syed A. Ahmed, T. Craig Cheetham, Joanie Chung, Chantal Avila, Ken Kleinman, Laurel A. Habel, Suzanne W. Fletcher, Marilyn L. Kwan
Journal: JNCI Journal of the National Cancer Institute (2015)

Background:Controversy persists about whether certain antidepressants reduce tamoxifen's effectiveness on lowering breast cancer recurrence. We investigated whether taking tamoxifen and antidepressants (in particular, paroxetine) concomitantly is associated with an increased risk of recurrence or contralateral breast cancer.
Allergy and Asthma--New Trends and Approaches to Therapy
Journal: Thorax (1990)

A 61-year-old man presented to a country clinic with involuntary orofacial movements and progressive cognitive decline, causing significant disability and psychosocial distress. Review of records uncovered a 7-year history of presentations to several specialties, including memory clinics, neurology, internal medicine and emergency departments, with varied symptoms, extensive complex work up and inconclusive diagnosis. Comprehensive review at our hospital highlighted inconsistent neurological signs, fluctuating cognition and psychosocial stressors, which preceded symptom onset, leading to the diagnosis of a functional movement disorder (FMD), which subsequently improved with relaxation therapy, cognitive–behavioural therapy and physiotherapy. We illustrate a variety of somatic symptoms, diagnostic clues and management outcomes for FMDs, and the importance of diagnostic criteria to minimise costly, time-consuming and ultimately unnecessary tests of exclusion.
Identifying Opportunities for Alignment in Pediatric Residency Training
Authors: Allison Ballantine, Lisa B. Zaoutis
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Peripheral blood minimal residual disease may replace bone marrow minimal residual disease as an immunophenotypic biomarker for impending relapse in acute myeloid leukemia
Authors: W Zeijlemaker, A Kelder, Y J M Oussoren-Brockhoff, W J Scholten, A N Snel, D Veldhuizen, J Cloos, G J Ossenkoppele, G J Schuurhuis
Journal: Leukemia (2015)
Prospective Clinical Study of Precision Oncology in Solid Tumors
Authors: Davendra P. S. Sohal, Brian I. Rini, Alok A. Khorana, Robert Dreicer, Jame Abraham, Gary W. Procop, Yogen Saunthararajah, Nathan A. Pennell, James P. Stevenson, Robert Pelley, Bassam Estfan, Dale Shepard, Pauline Funchain, Paul Elson, David J. Adelstein, Brian J. Bolwell
Journal: JNCI Journal of the National Cancer Institute (2015)

Systematic studies evaluating clinical benefit of tumor genomic profiling are lacking. We conducted a prospective study in 250 patients with select solid tumors at the Cleveland Clinic. Eligibility required histopathologic diagnosis, age of 18 years or older, Eastern Cooperative Oncology Group performance status 0–2, and written informed consent. Tumors were sequenced using FoundationOne (Cambridge, MA). Results were reviewed at the Cleveland Clinic Genomics Tumor Board. Outcomes included feasibility and clinical impact. Colorectal (25%), breast (18%), lung (13%), and pancreatobiliary (13%) cancers were the most common diagnoses. Median time from consent to result was 25 days (range = 3–140). Of 223 evaluable samples, 49% (n = 109) of patients were recommended a specific therapy, but only 11% (n = 24) received such therapy: 12 on clinical trials, nine off-label, three on-label. Lack of clinical trial access (n = 49) and clinical deterioration (n = 29) were the most common reasons for nonrecommendation/nonreceipt of genomics-driven therapy.
Salivary changes in oral mucosal diseases
Authors: Yazan Hassona, Crispian Scully
Journal: Periodontology 2000 (2015)

Abstract Saliva is a unique biological fluid that can be easily collected and analyzed with low cost and low morbidity. Therefore, there is a growing attention for using salivary biomarkers in the diagnosis and monitoring of disease progress and response to treatment. Salivary changes have been described in relation to oral mucosal diseases. This article discusses the causes and consequences of salivary hypofunction and presents a review of the literature related to changes in salivary parameters in various oral mucosal diseases and in systemic diseases with possible oral mucosal involvement.
Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene
Authors: Amalia Barreto-Luis, Maria Pino-Yanes, Almudena Corrales, Paloma Campo, Ariel Callero, Marialbert Acosta-Herrera, José Cumplido, Shwu-Fan Ma, Juan Martinez-Tadeo, Jesús Villar, Joe G.N. Garcia, Teresa Carrillo, Ángel Carracedo, Miguel Blanca, Carlos Flores
Journal: Journal of Allergy and Clinical Immunology (2015)
Abstract 19410: Stroke and CHADS2 Score Do Not Predict Warfarin Use Nationally in Atrial Fibrillation
Authors: Geoffery D Barnes, Sanders Chae, James B Froehlich
Journal: Circulation (2010)

Background: Atrial fibrillation (AF) carries a significant stroke risk, which is commonly estimated by the CHADS2 scoring system. While multiple centers have reported under-utilization of warfarin ...
GW26-e2161 Optimal Cutoff of the Triglyceride to High-Density-Lipoprotein Cholesterol Ratio to Detect Cardiovascular Risk Factors Among Han Adults in Xinjiang
Authors: Huayin Li, Bangdang Chen, Yining Yang, Xiang Ma, Fen Liu, Zhenyan Fu, Xiang Xie, Xiaomei Li, Shuo Pan, Chunhui He, Yingying Zheng, Yun Wu, Jing Tao, Chunlan Dong, Tingting Wu, Yitong Ma
Journal: Journal of the American College of Cardiology (2015)
Abstract 18264: High Prevalence of Arterial Hypertension in Adults With Repaired Coarctation of the Aorta
Authors: Daniel Rinnström, Mikael Dellborg, Ulf Thilén, Bengt Johansson
Journal: Circulation (2013)

Aim: Arterial hypertension is a long-term complication in adults with coarctation of the aorta (CoA) and may potentially affect prognosis. Here we have investigated the prevalence of hypertension, analysed associated factors, and evaluated blood pressure at the latest clinical visit. Methods: The national registry of congenital heart disease was searched for adults with previous surgery for CoA. The diagnosis of hypertension was defined as either registry diagnosis of hypertension and/or medical treatment consistent with this diagnosis. Results: 527 adult patients with CoA (mean age 38.5±14.5 years) and previous surgery were identified of whom 39.5 % had arterial hypertension. The prevalence of arterial hypertension increased with age and was more common among men (44.1 % vs. 32.0 %, p=0.006). Age, body mass index and peak systolic velocity in the descending aorta were independently associated with hypertension (Nagelkerke R2=0.222, p&lt;0.001). At the latest clinical visit, blood pressure was over 140/90 - a usually referred target value for treatment - in 53.0 % patients with the diagnosis of hypertension. Among these, men were more likely than women to have blood pressure over 140/90. Conclusion: Arterial hypertension is common in CoA and increases with age. In this registry study, blood pressure was above recommended levels in approximately half of the patients with CoA and hypertension, and more commonly among men.
Investigation of engagement of viewers in movie trailers using electroencephalography
Authors: Dayoon Kang, Jinsoo Kim, Dong-Pyo Jang, Yang Seok Cho, Sung-Phil Kim
Journal: Brain-Computer Interfaces (2015)

Brain-computer interfaces (BCIs) have been focused on providing direct communications to the disabled. Recently, BCI researchers have expanded BCI applications to non-medical uses and categorized them as active BCI, reactive BCI, and passive BCI. Neurocinematics, a new application of reactive BCIs, aims to understand viewers' cognitive and affective responses to movies from neural activity, providing more objective information than traditional subjective self-reports. However, studies on analytical indices for neurocinematics have verified their indices by comparisons with self-reports. To overcome this contradictory issue, we proposed using an independent psychophysical index to evaluate a neural engagement index (NEI). We made use of the secondary task reaction time (STRT), which measures participants' engagement in a primary task by their reaction time to a secondary task; here, responding to a tactile stimulus was the secondary task and watching a movie trailer was the primary task. NEI was developed as changes in the difference between frontal beta and alpha activity of EEG. We evaluated movie trailers using NEI, STRT, and self-reports and found a significant correlation between STRT and NEI across trailers but no correlation between any of the self-report results and STRT or NEI. Our results suggest that NEI developed for neurocinematics may conform well with more objective psychophysical assessments but not with subjective self-reports.
Treatment outcomes, quality of life, and impact of hemophilia on young adults (aged 18–30 years) with hemophilia
Authors: Michelle Witkop, Christine Guelcher, Angela Forsyth, Sarah Hawk, Randall Curtis, Laureen Kelley, Neil Frick, Michelle Rice, Gabriela Rosu, David L. Cooper
Journal: American Journal of Hematology (2015)

The Hemophilia Experiences, Results and Opportunities (HERO) initiative assessed psychosocial issues reported by people with moderate to severe hemophilia and was led by a multidisciplinary international advisory board. This analysis reports data from young adult respondents (aged 18–30 years), including both US and overall global (including US respondents) results, and investigates treatment outcomes, quality of life, and impacts of hemophilia on relationships. More young adults in HERO received prophylaxis than on‐demand treatment, although a majority reported not using factor products exactly as prescribed, and 50% of global respondents and 26% of US respondents reported issues with access to factor replacement therapy in the previous 5 years. Many young adults with hemophilia reported comorbidities, including bone/skeletal arthritis, chronic pain, and viral infections, and nearly half of young adults reported anxiety/depression. Most reported pain interference with daily activities in the past 4 weeks, although a majority reported participating in lower‐risk activities and approximately half in intermediate‐risk activities. Most young adults were very or quite satisfied with the support of partners/spouses, family, and friends, although roughly one‐third reported that hemophilia affected their ability to develop close relationships with a partner. A majority of young adults reported that hemophilia has had a negative impact on employment, and 62% of global respondents and 78% of US respondents were employed at least part‐time. Together these data highlight the psychosocial issues experienced by young adults with hemophilia and suggest that increased focus on these issues may improve comprehensive care during the transition to adulthood. Am. J. Hematol. 90:S3–S10, 2015. © 2015 Wiley Periodicals, Inc.
Promoting Physical Activity With the Out of School Nutrition and Physical Activity (OSNAP) Initiative
Authors: Angie L. Cradock, Jessica L. Barrett, Catherine M. Giles, Rebekka M. Lee, Erica L. Kenney, Madeleine E. deBlois, Julie C. Thayer, Steven L. Gortmaker
Journal: JAMA Pediatrics (2015)

<h3>Importance</h3> Millions of children attend after-school programs in the United States. Increasing physical activity levels of program participants could have a broad effect on children's health. <h3>Objective</h3> To test the effectiveness of the Out of School Nutrition and Physical Activity (OSNAP) Initiative in increasing children's physical activity levels in existing after-school programs. <h3>Design, Setting, and Participants</h3> Cluster-randomized controlled trial with matched program pairs. Baseline data were collected September 27 through November 12, 2010, with follow-up data collected April 25 through May 27, 2011. The dates of our analysis were March 11, 2014, through August 18, 2015. The setting was 20 after-school programs in Boston, Massachusetts. All children 5 to 12 years old in participating programs were eligible for study inclusion. <h3>Interventions</h3> Ten programs participated in a series of three 3-hour learning collaborative workshops, with additional optional opportunities for training and technical assistance. <h3>Main Outcomes and Measures</h3> Change in number of minutes and bouts of moderate to vigorous physical activity, vigorous physical activity, and sedentary activity and change in total accelerometer counts between baseline and follow-up. <h3>Results</h3> Participants with complete data were 402 racially/ethnically diverse children, with a mean age of 7.7 years. Change in the duration of physical activity opportunities offered to children during program time did not differ between conditions (−1.2 minutes; 95% CI, −14.2 to 12.4 minutes;<i>P</i> = .87). Change in moderate to vigorous physical activity minutes accumulated by children during program time did not differ significantly by intervention status (−1.0; 95% CI, −3.3 to 1.3;<i>P</i> = .40). Total minutes per day of vigorous physical activity (3.2; 95% CI, 1.8-4.7;<i>P</i> &lt; .001), vigorous physical activity minutes in bouts (4.1; 95% CI, 2.7-5.6;<i>P</i> &lt; .001), and total accelerometer counts per day (16 894; 95% CI, 5101-28 686;<i>P</i> = .01) increased significantly during program time among intervention participants compared with control participants. <h3>Conclusions and Relevance</h3> Although programs participating in the OSNAP Initiative did not allot significantly more time for physical activity, they successfully made existing time more vigorously active for children receiving the intervention. <h3>Trial Registration</h3> clinicaltrials.gov Identifier:NCT01396473
Abstract 5597: Does Warfarin-Based Anticoagulation Improve Outcomes After Acute Myocardial Infarction? A Meta-Analysis of Randomized Clinical Trials
Authors: Salman A Haq, John F Heitner, Terrence J Sacchi, Sorin J Brener
Journal: Circulation (2008)

Antiplatelet therapy is the principal component of the antithrombotic regimen after acute myocardial infarction (AMI). It remains unclear whether additional routine antithrombin therapy with chronic oral anticoagulation (OAC) improves outcomes. Using the Ovid SP and PubMed databases, we performed a comprehensive search for randomized clinical trials comparing warfarin-containing regimens with or without aspirin (OAC) with non-warfarin-containing regimens with or without aspirin (No OAC) for patients with recent AMI, regardless of reperfusion and adjunctive medical therapies provided during hospital stay. The studies had to provide follow-up for at least one month and have mortality as endpoint. Meta-analysis techniques were employed to calculate the relative risk (RR, fixed effect) for all-cause death at the longest interval of follow-up available. Between 1965 and 2006, 32 studies were identified and 11 were included in the meta-analysis. Among 23,803 patients, 13,070 were assigned to OAC and 10,733 to No OAC. The patients were followed for 3–79 months. Death occurred in 1,199 and 1,162 patients, respectively, RR 1.00 (0.995–1.010) (Figure ). After excluding studies without background aspirin therapy, death occurred in 1,057 and 993 patients, respectively (8 studies, RR 1.00 [0.992–1.008]). OAC with or without aspirin background therapy does not reduce mortality after AMI.