Phytobezoar Formation: A New Complication of Cimetidine Therapy
Authors: TRENT W. NICHOLS
Journal: Annals of Internal Medicine (1981)

Brief Reports1 July 1981Phytobezoar Formation: A New Complication of Cimetidine TherapyTRENT W. NICHOLS Jr., M.D.TRENT W. NICHOLS Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-1-70 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCimetidine, a histamine 2 (H-2) receptor antagonist of acid secretion, is a popular and well-accepted treatment. Its therapeutic efficacy in gastric ulceration (1), reflux esophagitis (2), and anastomotic ulceration after gastric surgery (3) has been documented. Gastric phytobezoar formation during cimetidine therapy was previously reported in a patient with peptic esophageal ulceration (4). Since then three additional patients have been seen in whom phytobezoars developed during cimetidine therapy; they are the subjects of this report.Patient 1:A previously described (4) 55-year-old edentulous white woman with an endoscopically proven esophageal ulceration developed a gastric phytobezoar 14 days after treatment with...References1. FRESTON J. Cimetidine in the treatment of gastric ulcer: review and commentary. Gastroenterology. 1978;74:426-30. CrossrefMedlineGoogle Scholar2. BEHARBRANDBROWN JDF. Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. Gastroen terology. 1978;74:441-8. CrossrefMedlineGoogle Scholar3. FESTENLAMERSDRIESSENVAN TONGEREN HCWJ. Cimetidine in anastomotic ulceration after partial gastrectomy. Gastroenterology. 1979;77:83-5. CrossrefMedlineGoogle Scholar4. NICHOLS T. Cimetidine and phytobezoars. Lancet. 1978;2:1263. Letter. CrossrefMedlineGoogle Scholar5. BRADY P. Gastric phytobezoars consequent to delayed gastric emptying. Gastrointest Endosc. 1978;24:159-61. CrossrefMedlineGoogle Scholar6. MALAGELADA J. Physiologic basis and clinical significance of gastric emptying disorders. Dig Dis Sci. 1979;24:657-61. Editorial. CrossrefMedlineGoogle Scholar7. HEADINGLOGANMCLAUGHLINLIGARDFORREST RRGGJ. Effects of cimetidine on gastric emptying. In: BURLAND WL, SIMKUS MA, eds. Cimetidine: Proceedings of the 2nd International Symposium on Histamine H2 Receptor Antagonists. Amsterdam: Excerpta Medica; 1977:145-51. Google Scholar8. RICHARDSONWALSHHICKS CJM. The effect of cimetidine, a new histamine H:-receptor antagonist, on meal-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcer. Gastroenterology. 1976;71:19-23. CrossrefMedlineGoogle Scholar9. DUBOISHAMILTONCASTELL ABD. Histamine 2 receptor involvement in the regulation of gastric emptying. Gastroenterology. 1977;72:1051. Abstract. Google Scholar10. RICHARDSON C. Effect of H:-receptor antagonists on gastric acid secretion and serum gastrin concentration: a review. Gastroenterology. 1978;74:366-70. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hanover General Hospital Hanover, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGastric and enteric phytobezoars caused by ingestion of persimmon in equidsMedication Bezoars: A Literature Review and Report of a CaseTricobezoar gástrico: relato de caso e revisão da literaturaForeign Bodies, Bezoars, and Caustic IngestionH2 Antagonists, Restless Leg Syndrome, and Movement DisordersGastric emptying and bezoars in JapaneseEndoscopic fragmentation of gastric phytobezoar by electrohydraulic lithotripsyGastric emptying and bezoarsMiscellaneous Gastroduodenal PathologyBezoars—when the ‘knot in the stomach’ is realRanitidine: A New H 2 -Receptor AntagonistOral administration of spermine inhibits gastric acid secretion in ratsAcute Renal FailureAntihistaminesAntacid Bezoar in a Premature Infant 1 July 1981Volume 95, Issue 1Page: 70-70KeywordsGastric ulcersHistaminePeptic ulcersReceptor antagonist therapySurgery Issue Published: 1 July 1981 PDF DownloadLoading ...