tbuckley/cabot-search huggingface dataset:
International Society of Geriatric Oncology Consensus on Geriatric Assessment in Older Patients With Cancer
Authors: Hans Wildiers, Pieter Heeren, Martine Puts, Eva Topinkova, Maryska L.G. Janssen-Heijnen, Martine Extermann, Claire Falandry, Andrew Artz, Etienne Brain, Giuseppe Colloca, Johan Flamaing, Theodora Karnakis, Cindy Kenis, Riccardo A. Audisio, Supriya Mohile, Lazzaro Repetto, Barbara Van Leeuwen, Koen Milisen, Arti Hurria
Journal: Journal of Clinical Oncology (2014)

To update the International Society of Geriatric Oncology (SIOG) 2005 recommendations on geriatric assessment (GA) in older patients with cancer.SIOG composed a panel with expertise in geriatric oncology to develop consensus statements after literature review of key evidence on the following topics: rationale for performing GA; findings from a GA performed in geriatric oncology patients; ability of GA to predict oncology treatment–related complications; association between GA findings and overall survival (OS); impact of GA findings on oncology treatment decisions; composition of a GA, including domains and tools; and methods for implementing GA in clinical care.GA can be valuable in oncology practice for following reasons: detection of impairment not identified in routine history or physical examination, ability to predict severe treatment-related toxicity, ability to predict OS in a variety of tumors and treatment settings, and ability to influence treatment choice and intensity. The panel recommended that the following domains be evaluated in a GA: functional status, comorbidity, cognition, mental health status, fatigue, social status and support, nutrition, and presence of geriatric syndromes. Although several combinations of tools and various models are available for implementation of GA in oncology practice, the expert panel could not endorse one over another.There is mounting data regarding the utility of GA in oncology practice; however, additional research is needed to continue to strengthen the evidence base.
Octreotide Alone or With Prednisone in Patients With Advanced Thymoma and Thymic Carcinoma: An Eastern Cooperative Oncology Group Phase II Trial
Authors: Patrick J. Loehrer, Wei Wang, David H. Johnson, David S. Ettinger
Journal: Journal of Clinical Oncology (2004)

Purpose To determine the objective response rate, duration of remission and toxicity of octreotide alone or with the later addition of prednisone in patients with unresectable, advanced thymic malignancies in whom the pretreatment octreotide scan was positive. Patients and Methods Forty-two patients with advanced thymoma or thymic carcinoma were entered onto the trial, of whom 38 were fully assessable (one patient had inconclusive histology; three patients had negative octreotide scan). Patients received octreotide 0.5 mg subcutaneously tid. At 2 months, patients were evaluated. Responding patients continued to receive octreotide alone; patients with progressive disease were removed from the study. All others received prednisone 0.6 mg/kg orally qid for a maximum of 1 year. Results Two complete (5.3%) and 10 partial responses (25%) were observed (four partial responses with octreotide alone; the remainder with octreotide plus prednisone). None of the six patients without pure thymoma responded. The 1- and 2-year survival rates were 86.6% and 75.7%, respectively. Patients with an Eastern Cooperative Oncology Group performance status of 0 lived significantly longer than did those with a performance status of 1 (P = .031). Conclusion Octreotide alone has modest activity in patients with octreotide scan–positive thymoma. Prednisone improves the overall response rate but is associated with increased toxicity. Additional studies with the agent are warranted.
Stiffness of the Great Toe in Adolescents
Authors: J. M. Cotterill
Journal: BMJ (1887)

any disposition of that part, even when no structural change is appa- rent in it, to occupy the room provide(d.The sock may easily cause sufficient pressure to prevent this, and the best plan is to cut a hole in it, in that way setting perfectly free the great toe, which may be clothed with a few turnis of bandage tied around.In time, socks may be substituted having a straight inner line, or, better still, a separate stall for the great toe.The invitation to occupy the space provided in the boot must also be kept open ; the leather must not be allowed to fall in, but be frequently pressed upwards, and may, when the boot is not in use, be supported by wool stuffed within.Better still, of course, is the use of a well-made boot-tree.MIore generally
A Limited Epizootic of Neuroblastoma in Coho Salmon Reared in Chlorinated-Dechlorinated Water&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: T R Meyers, J D Hendricks
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article A Limited Epizootic of Neuroblastoma in Coho Salmon Reared in Chlorinated-Dechlorinated Water Get access Theodore R. Meyers, Theodore R. Meyers Search for other works by this author on: Oxford Academic PubMed Google Scholar Jerry D. Hendricks Jerry D. Hendricks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 72, Issue 2, February 1984, Pages 299–310, https://doi.org/10.1093/jnci/72.2.299 Published: 01 February 1984 Article history Received: 11 May 1982 Accepted: 12 August 1983 Revision received: 25 August 1983 Published: 01 February 1984
Inhibition of Metastasis of Tumor Cells Overexpressing Thymidine Phosphorylase by 2-Deoxy-<scp>l</scp>-Ribose
Authors: Yuichi Nakajima, Takenari Gotanda, Hiroshi Uchimiya, Tatsuhiko Furukawa, Misako Haraguchi, Ryuji Ikeda, Tomoyuki Sumizawa, Hiroki Yoshida, Shin-ichi Akiyama
Journal: Cancer Research (2004)

Thymidine phosphorylase (TP) catalyzes the reversible conversion of thymidine to thymine, thereby generating 2-deoxy-D-ribose-1-phosphate, which upon dephosphorylation forms 2-deoxy-D-ribose (D-dRib), a degradation product of thymidine. We have previously shown that D-dRib promotes angiogenesis and chemotaxis of endothelial cells and also confers resistance to hypoxia-induced apoptosis in some cancer cell lines. 2-Deoxy-L-ribose (L-dRib), a stereoisomer of D-dRib, can inhibit D-dRib anti-apoptotic effects and suppressed the growth of KB cells overexpressing TP (KB/TP cells) transplanted into nude mice. In this study, we examined the ability of L-dRib to suppress metastasis of KB/TP cells using two different models of metastasis. The antimetastatic effect of L-dRib was first investigated in a liver-metastasis model in nude mice inoculated with KB/TP cells. Oral administration of L-dRib for 28 days at a dose of 20 mg/kg/day significantly reduced the number of metastatic nodules in the liver and suppressed angiogenesis and enhanced apoptosis in KB/TP metastatic nodules. Next, we compared the ability of L-dRib and tegafur alone or in combination to decrease the number of metastatic nodules in organs in the abdominal cavity in nude mice receiving s.c. of KB/TP cells into their backs. L-dRib (20 mg/kg/day) was significantly (P < 0.05) more efficient than tegafur (100 mg/kg/day) in decreasing the number of metastatic nodules in organs in the abdominal cavity. By in vitro invasion assay, L-dRib also reduced the number of invading KB/TP cells. L-dRib anti-invasive activity may be mediated by its ability to suppress the enhancing effect of TP and D-dRib on both mRNA and protein expression of vascular endothelial growth factor and interleukin-8 in cultured KB cells. These findings suggest that L-dRib may be useful in a clinical setting for the suppression of metastasis of tumor cells expressing TP.
An Atlas of Diagnostic Radiology in Gastroenterology
Authors: I. FORGACS
Journal: Gut (2000)

DiVerential expression of cyclooxygenase 2 in human colorectal cancerEDITOR,-We were puzzled by the recent paper by Dimberg and colleagues (Gut 1999;45:730-732) which reported that upregulation of cyclooxygenase 2 (COX-2) protein expression was prominent in rectal adenocarcinomas compared with that in adenocarcinomas arising from the colon."Low or undetectable levels of COX-2 protein expression" were demonstrated in 15 of 19 colonic adenocarcinomas located proximal to the rectum.Overall, upregulation of COX-2 protein expression was reported in only 56% of colorectal cancers.Previous reports, 1-7 which include one by the current authors on a not dissimilar case series, 1 and two in the joint authorship of the accompanying commentary writer, 2 3 have shown consistent upregulation of COX-2 expression in colonic and rectal adenocarcinomas (in 85-90% of cases) compared with matched normal colonic mucosa using diVerent techniques, including northern blot analysis, RT-PCR, western blot analysis, and immunohistochemistry. Furthermore, four of these studies refer to the distribution of adenocarcinomas throughout the colon without showing evidence of diVerential COX-2 expression between rectal and more proximal tumours. 1 2 4 5 In the one previous study which analysed COX-2 protein expression in human colorectal cancers by western blot analysis, 7 immunoreactive COX-2 was detected in 76% of cases with a 10-fold increase in median tissue COX-2 concentration compared with normal colonic mucosa.In our view, the authors should attempt to explain the discrepancy between their results and previously published data.It is interesting to note that, in the study of Kargman et al, five of six patients taking NSAIDs had low or undetectable COX-2 protein expression. 7Moreover, aspirin has recently been shown to suppress induction of COX-2 mRNA and protein in interleukin-1 and phorbol ester stimulated human endothelial cells and fibroblasts. 8Do the authors have data on NSAID use in their cohort of patients prior to surgery?
Nodular and bullous cutaneous mastocytosis of the xanthelasmoid type: case report
Authors: R. Husak, U. Blume-Peytavi, C. Pfrommer, C.C. Geilen, S. Goerdt, C.E. Orfanos
Journal: British Journal of Dermatology (2001)

Journal Article Nodular and bullous cutaneous mastocytosis of the xanthelasmoid type: case report Get access R. Husak, R. Husak Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar U. Blume‐Peytavi, U. Blume‐Peytavi Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar C. Pfrommer, C. Pfrommer Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar C.C. Geilen, C.C. Geilen Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar S. Goerdt, S. Goerdt Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar C.E. Orfanos C.E. Orfanos Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 2, 1 February 2001, Pages 355–358, https://doi.org/10.1046/j.1365-2133.2001.04026.x Published: 01 February 2001
Research on Culture-Bound Syndromes: New Directions
Authors: P J Guarnaccia, L H Rogler
Journal: American Journal of Psychiatry (1999)

The unprecedented inclusion of culture-bound syndromes in DSM-IV provides the opportunity for highlighting the need to study such syndromes and the occasion for developing a research agenda to study them. The growing ethnic and cultural diversity of the U.S. population presents a challenge to the mental health field to develop truly cross-cultural approaches to mental health research and services. In this article, the authors provide a critique of previous analyses of the relationship between culture-bound syndromes and psychiatric diagnoses. They highlight the problems in previous classificatory exercises, which tend to focus on subsuming the culture-bound syndromes into psychiatric categories and fail to fully investigate these syndromes on their own terms. A detailed research program based on four key questions is presented both to understand culture-bound syndromes within their cultural context and to analyze the relationship between these syndromes and psychiatric disorders. Results of over a decade of research on ataques de nervios, a Latino-Caribbean cultural syndrome, are used to illustrate this research program. The four questions focus on the nature of the phenomenon, the social-cultural location of sufferers, the relationship of culture-bound syndromes to psychiatric disorders, and the social and psychiatric history of the syndrome in the life course of the sufferer.
Immunohistochemical Distribution of Cyclic GMP-Dependent Protein Kinase-1 in Human Prostate Tissue
Authors: Eginhard S. Waldkirch, Stefan Ückert, Kristina Langnäse, Karin Richter, Udo Jonas, Gerald Wolf, Karl-Erik Andersson, Christian G. Stief, Petter Hedlund
Journal: European Urology (2007)
Depletion of T-cell intracellular antigen proteins promotes cell proliferation
Authors: Raquel Reyes, José Alcalde, José M Izquierdo
Journal: Genome biology (2009)

T-cell intracellular antigen-1 (TIA-1) and TIA-1 related/like protein (TIAR/TIAL1), two DNA/RNA binding proteins broadly expressed in eukaryotic cells, participate in the regulation of gene expression through RNA metabolism. Despite the biological relevance of these regulators, there are no genome-wide studies assessing global transcriptomic and phenotypic impacts after changes in the expression and/or function of these proteins. Using high-throughput gene expression profiling, we found that the TIA-1/TIAR-depleted cell phenotype is linked to a transcriptome involved in the control of inflammation, cell-cell signaling, immune-suppression, angiogenesis, metabolism and cell proliferation. Induced genes included pro-inflammatory cytokines, inflammatory chemokines, growth-stimulating factors and pro-angiogenic inducers. Repressed genes involved the RAS oncogene family member RAB40B, regulators of cytoskeleton organization and biogenesis and a mitochondrial modulator. Consistent with these observations, depletion of TIA proteins in HeLa cells results in increased cell proliferation, altered cell-cycle and anchorage-independent growth. Mechanistically, the changes associated with the steady-state target mRNA levels regulated by TIA proteins are consistent with overlapping effects on gene basal transcription rate and mRNA turnover. Collectively, our findings suggest a role for TIA proteins as cellular sensors that modulate gene expression control at the transcriptional and post-transcriptional levels, coupling cell proliferation responses and metabolic homeostasis to cell survival and growth.
Resident physician substance use, by specialty
Authors: P H Hughes, D C Baldwin, D V Sheehan, S Conard, C L Storr
Journal: American Journal of Psychiatry (1992)

This study compares substance use by medical specialty among resident physicians.The authors estimated the prevalence of substance use of 11 medical specialties from a national sample of 1,754 U.S. resident physicians.Emergency medicine and psychiatry residents showed higher rates of substance use than residents in other specialties. Emergency medicine residents reported more current use of cocaine and marijuana, and psychiatry residents reported more current use of benzodiazepines and marijuana. Contrary to recent concerns, anesthesiology residents did not have high rates of substance use. Family/general practice, internal medicine, and obstetrics/gynecology were not among the higher or lower use groups for most substances. Surgeons had lower rates of substance use except for alcohol. Pediatric and pathology residents were least likely to be substance users.The authors' previous research indicates that residents overall have lower rates of substance use than their age peers in society. Yet resident substance use patterns do differ by specialty. Residents in some specialties are more likely to use specific classes of drugs, to use a greater number of drug classes, and to be daily users of alcohol or cigarettes.
Underuse of Evidence-Based Therapies
Authors: Mark A. Hlatky
Journal: Circulation (2004)

ardiovascular specialists have been leaders in medicine because of our willingness to study major clinical issues by means of randomized clinical trials.Consequently, the evidence supporting many cardiovascular treatments is substantial, especially when the results of multiple large clinical trials are consistent in showing strong benefits.Cardiovascular professional societies also have been at the forefront in forging consensus among clinical experts and codifying best practice into practice guidelines.It is reasonable to expect that a treatment demonstrated to be effective in clinical trials and strongly endorsed by professional guidelines will be adopted by practicing physicians and consistently used in day-to-day patient care.
Restrictive Annuloplasty and Coronary Revascularization in Ischemic Mitral Regurgitation Results in Reverse Left Ventricular Remodeling
Authors: Jeroen J. Bax, Jerry Braun, Soeresh T. Somer, Robert Klautz, Eduard R. Holman, Michel I.M. Versteegh, Eric Boersma, Martin J. Schalij, Ernst E. van der Wall, Robert A. Dion
Journal: Circulation (2004)

Background— Data on combined coronary artery bypass grafting (CABG) and restrictive annuloplasty in patients with ischemic cardiomyopathy are scarce, and the effect on reverse left ventricular (LV) remodeling is unknown. Methods and Results— 51 patients with ischemic LV dysfunction (LV ejection fraction 31±8%) and severe mitral regurgitation (grade 3 to 4+) underwent CABG and restrictive annuloplasty with stringent downsizing of the mitral annulus (by 2 sizes, Physio-ring, mean size 28±2). Serial transthoracic echocardiographic studies were performed (before surgery and within 3 months and 1.5 years after surgery) to assess mitral regurgitation, transmitral gradient, leaflet coaptation, and left atrial and LV reverse remodeling. Clinical follow-up (New York Heart Association [NYHA] class, survival, events) was assessed at 2-year follow-up. Early operative mortality was 5.6%; at 2-year follow-up, all patients were free of endocarditis and thromboembolism, and 1 needed re-operation for recurrent mitral regurgitation; 2-year survival was 84%. NYHA class improved from 3.4±0.8 to 1.3±0.4 ( P &lt;0.01), with all patients in class I/II. Intraoperative transesophageal echo showed minimal (grade 1+) mitral regurgitation in 8 patients and none in 43, without stenosis. Leaflet coaptation was 0.8±0.2 cm. These values remained unchanged; all patients had no or minimal (grade 1+) mitral regurgitation at 2-year follow-up. LV end-systolic and end-diastolic dimensions decreased from 51±10 to 43±12 mm ( P &lt;0.001) and from 64±8 to 58±11 mm ( P &lt;0.001). Left atrial dimension decreased from 53±8 to 47±7 mm ( P &lt;0.001). Conclusion— Excellent results of combined restrictive annuloplasty and CABG were obtained. Residual mitral regurgitation was absent/minimal at 2-year follow-up, associated with a significant reduction in left atrial dimension and LV reverse remodeling.
The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation
Authors: Archana V. Boopathy, Pao Lin Che, Inthirai Somasuntharam, Vincent F. Fiore, E. Bernadette Cabigas, Kiwon Ban, Milton E. Brown, Yoshie Narui, Thomas H. Barker, Young-Sup Yoon, Khalid Salaita, Andrés J. García, Michael E. Davis
Journal: Biomaterials (2014)
Anatomic Relations Between the Esophagus and Left Atrium and Relevance for Ablation of Atrial Fibrillation
Authors: Damian Sánchez-Quintana, José Angel Cabrera, Vicente Climent, Jerónimo Farré, Maria Cristina de Mendonça, Siew Yen Ho
Journal: Circulation (2005)

Esophageal injury is a potential complication after intraoperative or percutaneous transcatheter ablation of the posterior aspect of the left atrium. Understanding the spatial relations between the esophagus and the left atrium is essential to reduce risks.We examined by gross dissection the course of the esophagus in 15 cadavers. We measured the minimal distance of the esophageal wall to the endocardium of the left atrium with histological studies in 12 specimens. To measure the transmural thickness of the atrial wall, we sectioned another 30 human heart specimens in the sagittal plane at 3 different regions of the left atrium. The esophagus follows a variable course along the posterior aspect of the left atrium; its wall was <5 mm from the endocardium in 40% of specimens. The posterior left atrial wall has a variable thickness, being thickest adjacent to the coronary sinus and thinnest more superiorly. Behind is a layer of fibrous pericardium and fibrofatty tissue of irregular thickness that contains esophageal arteries of 0.4+/-0.2-mm external diameters.The nonuniform thickness of the posterior left atrial wall and the variable fibrofatty layer between the wall and the esophagus are risk factors that must be considered during ablation procedure. Esophageal arteries and vagus nerve plexus on the anterior surface of the esophagus may be affected by ablative procedures.
Epidemiology and clinical pattern of psoriatic arthritis in Germany: a prospective interdisciplinary epidemiological study of 1511 patients with plaque-type psoriasis
Authors: K. Reich, K. Krüger, R. Mössner, M. Augustin
Journal: British Journal of Dermatology (2009)

Because psoriatic arthritis (PsA) usually develops years after the first manifestation of skin symptoms, in many cases the initial diagnosis of PsA depends on the dermatologist.To investigate the prevalence and clinical pattern of PsA in a daily practice population of patients with psoriasis.Patients were enrolled in an observational prospective cross-sectional cohort study at 48 community and academic centres. Demographic and medical parameters were recorded, including severity of skin symptoms (Psoriasis Area and Severity Index, PASI), previous and current treatments, concomitant diseases, and the impact of psoriasis on productivity and health-related quality of life (Dermatology Life Quality Index, DLQI). Patients with joint symptoms were referred to a rheumatologist for diagnosis and to record the activity and pattern of arthritis.Among 1511 patients 20.6% had PsA; in 85% of the cases PsA was newly diagnosed. Of these patients more than 95% had active arthritis and 53.0% had five or more joints affected. Polyarthritis (58.7%) was the most common manifestation pattern, followed by oligoarthritis (31.6%) and arthritis mutilans (4.9%). Distal interphalangeal involvement was present in 41.0% and dactylitis in 23.7% of the patients. Compared with patients without arthritis, patients with PsA had more severe skin symptoms (mean PASI 14.3 vs. 11.5), a lower quality of life (mean DLQI 11.6 vs. 7.7) and greater impairment of productivity parameters.The findings are consistent with a high prevalence of undiagnosed cases of active PsA among patients with psoriasis seen by dermatologists. As many of these patients also have significant skin symptoms, treatment strategies are required that are equally effective in the control of skin and joint symptoms of psoriasis.
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo
Authors: Joan Isern, Zhiyong He, Stuart T. Fraser, Sonja Nowotschin, Anna Ferrer-Vaquer, Rebecca Moore, Anna-Katerina Hadjantonakis, Vincent Schulz, David Tuck, Patrick G. Gallagher, Margaret H. Baron
Journal: Blood (2011)