tbuckley/cabot-search huggingface dataset:
Prognosis for Wilms' tumor patients with nonmetastatic disease at diagnosis--results of the second National Wilms' Tumor Study.
Authors: N Breslow, G Churchill, J B Beckwith, D J Fernbach, H B Otherson, M Tefft, G J D'Angio
Journal: Journal of Clinical Oncology (1985)

Multivariate statistical methods were used to study prognosis for 632 patients entered on the second National Wilms' Tumor Study who had nonmetastatic, unilateral disease at diagnosis. Separate analyses were conducted for each of four endpoints: abdominal recurrence, distant metastasis, relapse without regard to site, and death. The two most important predictors for metastasis and general relapse were an unfavorable (anaplastic or sarcomatous) histology and the presence of microscopically confirmed disease in the regional lymph nodes. Operative spillage of tumor increased the rates of abdominal recurrence and death, even after accounting for histology and lymph node effects. The presence of a tumor thrombus in the renal vein or IVC increased the risk of metastasis, and intrarenal vascular invasion was associated with general relapse after accounting for histology, lymph nodes, and spillage. However, these latter associations were weaker, and some uncertainty remains regarding the true prognostic import of such findings due to a high degree of collinearity among variables. By contrast to the results of a similar data analysis for the first National Wilms' Tumor Study, specimen weight had no bearing on outcome, and the effects of age at diagnosis were entirely explained by the association of age with other more critical factors.
Abstract P357: Genome-Wide Association Study of the PR Interval in Hispanic Populations
Authors: Amanda A Seyerle, Henry J Lin, Stephanie M Gogarten, Elsayed Z Soliman, Susan R Heckbert, Kathleen F Kerr, Charles Kooperberg, Carlos J Rodriguez, Xiuqing Guo, Kelli K Ryckman, Jie Yao, Nona Sotoodehnia, Kent D Taylor, Eric Whitsel, Jerome I Rotter, Cathy Laurie, Christy L Avery
Journal: Circulation (2015)

BACKGROUND: The PR interval (PR) is an electrocardiographic measure of atrial and atrioventricular nodal conduction. PR prolongation has been associated with atrial fibrillation, pacemaker implantation, heart failure, and all-cause mortality. Although Hispanic/Latino (HL) populations have high burdens of cardiovascular morbidity and mortality, they remain a chronically understudied population, with previous genome-wide association studies of PR limited to European (EU), African (AA), and Asian (AS) descent populations. METHODS: We included 13,507 participants of HL ancestry from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and Women’s Health Initiative clinical trials (WHI). PR was automatically measured from digital electrocardiogram tracings recorded using standardized methods in all participants. Genotype data were imputed to the 1000 Genomes Phase 1 reference panel, and associations were examined using linear regression assuming an additive genetic model and adjusting for global ancestry, study center or region, clinical covariates (age, sex, heart rate, height, body mass index, systolic blood pressure, beta blocker use), and study weights (HCHS/SOL only). Study-specific results were combined using a fixed-effects, inverse variance weighted meta-analysis. Linkage disequilibrium (LD) patterns were examined using LocusZoom, and r2 values were calculated using 1000 Genomes reference populations. RESULTS: We identified six loci associated with PR in HL populations at genome-wide significant levels: SLC8A1, SCN5A, SCN10A, ARHGAP24, CAV1/CAV2, and SOX5. At these loci, index SNPs had important effects (β range: 2-4 ms) and common minor allele frequencies (MAF range: 13-40%). Of note, five of the six identified loci were previously associated with PR in EU populations, and four in AA populations; however, the association with SLC8A1 has been found only in AS populations. Whereas the SLC8A1 index SNP, rs17026148, is common in AS (MAF = 50%), AA (MAF = 15%), and HL populations (MAF = 17%), it is rare in EU populations (MAF &lt; 5%). Interestingly, SLC8A1 LD patterns are similar across AS, EU, and HL populations in this region. CONCLUSIONS: Our results suggest that genetic determinants of PR are consistent across race/ethnicity but that previous studies in EU populations were either underpowered to detect the SLC8A1 locus or that it resides on an Asian/American Indian haplotype, thus underscoring the importance of conducting genetic studies in diverse populations.
All-trans retinoic acid: tolerance and biologic effects in myelodysplastic syndrome.
Authors: R Kurzrock, E Estey, M Talpaz
Journal: Journal of Clinical Oncology (1993)

We conducted a study to evaluate the tolerance to and biologic effects of all-trans retinoic acid in patients with myelodysplastic syndrome.Thirty-nine patients with myelodysplastic syndrome were treated with oral all-trans retinoic acid for 6 weeks. Dose levels were 10, 25, 50, 100, 150, 200, and 250 mg/m2/d. At least three patients were treated on each dose level.The most common side effects were mucocutaneous dryness and erythema, and hypertriglyceridemia. Dose-limiting side effects were diverse and included dermatitic problems, sensorineural hearing loss, headaches, nausea and vomiting, myalgias, and dyspnea. The maximum-tolerated dose was 150 mg/m2/d. Only one response was seen among 29 patients considered assessable for response.All-trans retinoic acid can be safely administered to patients at doses up to 150 mg/m2/d for 6 weeks. However, as administered in this study, this compound does not appear to have significant activity in myelodysplastic syndromes.
O015 : Quantitative measurements of mutations in basal core promotor region suggest a loss of immune tolerance in HBeAg positive chronic hepatitis B infections
Authors: G. Rosenberg, J. Bayliss, L. Yuen, A. Gaggar, K. Kitrinos, M. Subramanian, E. Gane, H.L. Chan, R. Hammond, S. Bowden, P. Revill, S. Locarnini, A. Thompson
Journal: Journal of Hepatology (2015)
Abstract 11539: Impact of Adipose Tissue Composition on Cardiovascular Risk Assessment
Authors: Ayako Kunimura, Tadayuki Uetani, Takashi Kataoka, Masahiro Takeshita, Kazuhiro Harada, Satoshi Okumura, Norihiro Shinoda, Ken Harada, Bunichi Kato, Masataka Kato, Nobuyuki Marui, Michio Nanki, Tatsuaki Matsubara, Hideki Ishii, Tetsuya Amano, Toyoaki Murohara
Journal: Circulation (2014)

Background: Visceral adipose tissue (VAT) , unlike subcutaneous adipose tissue (SAT), has been shown to be highly correlated with cardiovascular risk factors. The aim of this study was to evaluate the predictive value of adipose tissue composition measured by computed tomography for cardiovascular outcome. Method: 369 consecutive patients without history of cardiovascular disease who underwent 64-slice computed tomography angiography (CTA) were recruited. The ratio of visceral adipose tissue to the total adipose tissue (%VAT) was calculated as VAT/ (VAT + SAT) х 100. Patients were divided into three groups in accordance with tertiles of %VAT (tertile1, &lt;35.1%; tertile2, 35.1 to 45.0%; tertile3, 45.1%≤). The investigated risk factors were hypertension, hyperglycemia, and dyslipidemia. We analyzed the incidence of major adverse cardiac events (MACE), including cardiovascular death, myocardial infarction, and any revascularization. Result: The rate of patients who have two or more concomitant risk factors was significantly increased across tertiles of %VAT (p=0.001). During the median follow-up of 1973 days, 96 events occurred. Event-free survival was significantly associated with %VAT tertiles, with worse event-free survival in tertile 3 (log-rank p=0.001). In Cox analysis, the hazard ratio (HR) of %VAT (per tertile) for MACE was 1.39 (95% confident interval [CI] 1.05-1.82, p=0.02). Among patients with tertile 3, HR for MACE was 1.81 (95% CI 1.01-3.23, p=0.045) compared to tertile 1 after adjustment for confounding factors. Conclusion: %VAT is independently associated with MACE, indicating that adipose tissue composition is a useful predictor of cardiovascular outcome.
Characterization of a population referred to a lung transplantation centre in Lisbon
Authors: Sofia Granadeiro, Alexandra Borba, Luisa Semedo, Miguel Araujo, João Cardoso, Fernando Martelo, Jose Fragata
Journal: European Respiratory Journal (2011)

Introduction:  Lung transplantation is the therapeutic option for patients with end stage lung disease. An appropriate referral contributes to a better post surgery survival.   Purpose:  Characterization of the patients referred to the only lung transplantation centre in Portugal.   Material and method:  The authors evaluated patients referred from January 2008 to December 2010. The following data was determined: demographics, lung disease and evaluation result. Reasons for refusal were also analyzed.   Results:  A total of 199 patients were referred (61% male), with an medium age of 45,5 years (range 11 to 69). Thirty per cent had the diagnosis of terminal lung fibrosis, 21% COPD, 13% cystic fibrosis, 12% bronchiectasis and the last 23% other diagnosis. After evaluation 24,6% of patients were accepted (49 patients, 25 of which already transplanted and 5 died on waiting list) and 54,3% were refused, most due to severe cardiac impairment or very poor general condition. Of the remaining patients, 9,5% are under current evaluation, 6,5% present a relative contraindication and 5% still don9t meet criteria for transplantation.   Conclusion:  Despite the considerable number of patients referred, only 45,7% were eligible for lung transplant. The important number of patients refused due to medical contraindications should alert the attending physicians for an earlier referral.
Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia
Authors: Britta Will, Thomas O Vogler, Swathi Narayanagari, Boris Bartholdy, Tihomira I Todorova, Mariana da Silva Ferreira, Jiahao Chen, Yiting Yu, Jillian Mayer, Laura Barreyro, Luis Carvajal, Daniela Ben Neriah, Michael Roth, Johanna van Oers, Sonja Schaetzlein, Christine McMahon, Winfried Edelmann, Amit Verma, Ulrich Steidl
Journal: Nature Medicine (2015)
The Policing of Clinical Trials
Authors: George P. Canellos
Journal: Journal of Clinical Oncology (2000)

Article Tools EDITORIAL Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.12.2353 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10856093 The Policing of Clinical Trials George P. Canellos, MDxGeorge P. CanellosSearch for articles by this author https://doi.org/10.1200/JCO.2000.18.12.2353 Full Text PDF Figures and Tables "The Policing of Clinical Trials." Journal of Clinical Oncology, 18(12), p. 2353© 2000 by American Society of Clinical Oncology
CELLULAR DIFFERENTIATION OF THE IMMUNE SYSTEM OF MICE
Authors: G. Cudkowicz, G. M. Shearer, T. Ito
Journal: The Journal of Experimental Medicine (1970)

Marrow cells and 5 x 10(7) thymocytes of unprimed (C57BL/6 x DBA/2)F(1), (C57BL/10 x WB)F(1) and (C3H x C57BL)F(1) donor mice were mixed in vitro and transplanted into X-irradiated syngeneic hosts. Upon injection of sheep erythrocytes, splenic plaque-forming cells (PFC) secreting IgM (direct PFC or IgG (indirect PFC) hemolytic antibody were enumerated at the time of peak responses. By grading the numbers of marrow cells, inocula were found that contained few immunocompetent cells reaching the recipient spleens, interacting with thymocytes or other accessory cells (or both), and generating PFC. The frequency of responses in BDF(1) mice conformed to Poisson statistics, indicating that immunocompetent marrow cells participated in a single-hit interaction limiting PFC responses. The marrow cells assayed were not restricted for the antibody class (IgM versus IgG) to be secreted by mature PFC. Unrestricted marrow cells could have been either the precursors of PFC or accessory cells. Different results were obtained in BWF(1) and C3BF(1) mice. The frequency of responses in relation to the number of marrow cells grafted did not follow Poisson statistics, and the limiting cells were restricted for antibody class. Presumably, immunocompetent cells of these strains were more heterogeneous than those of BDF(1) mice and participated in a multiplicity of cell-to-cell interactions. The strain differences reflected inherent properties of marrow cells and not influences of the environment in which PFC were produced. The results confirmed for bone marrow the heterogeneity of immunocompetent cells reported by others for spleen, and suggested that genetic factors such as "immune response" genes regulate cellular differentiation also for functions other than those related to antibody specificity.
Serum antibodies specific for tumor antigens in colorectal cancer may be useful diagnostic biomarkers
Authors: H. Lu, V. Goodell, M. L. Disis
Journal: Journal of Clinical Oncology (2006)

10041 Background: Colorectal cancer is immunogenic as evidenced by the presence of antibodies specific to tumor antigens in patient serum and T cell infiltration at the tumor site predicting favorable disease outcome. We questioned whether antibody immunity to tumor associated antigens (TAA) in patients with colorectal cancer could be used as a biomarker to predict disease. Methods: We evaluated serum samples for the presence of antibody immunity to six tumor antigens, cyclin D1, HER-2/neu, insulin-like growth factor binding protein 2 (IGFBP2), NY-ESO-1, p53, and topoisomerase-IIα (TOPO2α), in colorectal cancer patients (n=40) and normal donors (n=200) using ELISA. We then evaluated the diagnostic value of these potential biomarkers by measuring antibody levels to these TAA in an independent sample set which included 30 colorectal cancer patients and 135 normal donors. The samples were judged as positive or negative for colorectal cancer using measurements derived either from a single marker or a combination of the markers. Receiver operating characteristic (ROC) plots were generated to determine the diagnostic accuracy of each test. Results: Colorectal cancer patients had increased levels of antibodies to p53 (p=0.002), TOPO2α (p&lt;0.001), and IGFBP2 (p&lt;0.001) compared to controls. By using a combination of just two antibody measurements, TOPO2α and IGFBP2, we could discriminate colorectal cancer patients from controls with a diagnostic power of 0.775 as estimated by the area under ROC curve. At a cutoff point of 0.03 mcg/ml TAA specific IgG, the sensitivity was 100% and the specificity was 58%. Conclusions: Serum antibodies to colorectal cancer related antigens may serve as useful biomarkers for colorectal cancer diagnosis. No significant financial relationships to disclose.
Are You as Old as Your Arteries or as Old as Your Coronary Artery Calcification Score?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Authors: François Schiele, Nicolas Meneveau
Journal: Journal of the American College of Cardiology (2009)
ELITE FEMALE RUGBY PLAYERS' (UNION VERSUS TOUCH): COMPARATIVE STUDY OF CERVICAL SPINE FUNCTION: Table 1
Authors: BB Zietsman, PW McCarthy
Journal: British Journal of Sports Medicine (2015)

Aim Elite male rugby union players have a decreased active cervical range of motion (ACROM), the severity of which appears to correlate with number of years playing and position.1 Although the female game has yet to attain full professional status, players are still subjected to the same game related activities and might be expected to similarly accumulate degenerative changes in vertebral joints.2 This study was designed to determine if playing a contact sport affects ACROM of elite female players, compared with a control of similar level of play in the non-contact equivalent (touch rugby). The presence and degree of such changes might be affected by issues such as BMI, speed and the physiological differences between males and females. Methods Protocol used is similar as that described by Lark and McCarthy, 2007. Briefly, a cervical range of motion device (CROM)3 was used to measure ACROM following a warm up procedure. From their neutral point to full flexion/extension and full left/right rotation was measured in no set order, (to reduce potential order effects). Ethical approval was granted by The Faculty of HSS Ethics Committee, University of Glamorgan, written informed consent was obtained from all subjects. Results 35 Welsh International Rugby Union players (WRU) volunteered, 29 included. Exclusions: 4 pain on extension, 2 whiplash, split into 15/29 backs (WRU B), 14/29 forwards (WRU F); matched to 22/32 Welsh International Touch Rugby players (WTR), 8 exclusions: 1 whiplash, 7 con-current elite union players. Table 1 Mass (Kg) Height (m) Neck (cm) Age (yrs) Elite Participation (yrs) Left Rotation Right Rotation Total Flexion Extension Total WTR (n=22) 61.7±6.0** 1.7±0.1 31.9±2.2** 29.1±5.6** 4.4±5.4 76.4±6.6** 73.3±6.8** 149.7±11.3** 51.0±12.8 78.8±13.5* 129.8±15** WRU F (n=14) 78.0±8.3 1.7±0.1 35.7±1.4 24.2±4.2 3.8±3.9 63.6±8.2 64.7±8.2 128.3±12.6 46.7±16.7 57.3±8.8 104.0±16.6 WRU B (n=15) 65.0±8.4** 1.7±0.1 33.8±1.3** 24.1±5.0 3.8±2.9 67.9±8.7 66.7±10.2 134.5±12.1 56.0±17.5 66.1±17.2* 122.1±19.9** The data was normally distributed (Shapiro-Wilkes), unpaired T-tests were used to compare players using SPSS V19. Data presented as mean ±1 SD: * indicates p&lt;0.05 and ** p&lt;0.01. Conclusions The decrease in ACROM for WRU relative to WTR players supports the contention that elite union leads to impaired neck function, regardless of the players' sex. Those in a forward position are particularly affected. This suggests that female elite union players have a similar risk of accelerated degeneration to the vertebral joints as their male counterparts. Further research is needed to determine cause, and whether any protocol can be established to lessen this effect.
Abstract P308: Lower Neighborhood Socioeconomic Status is Associated with Higher BNP and Prolonged QTc Intervals among Heart Failure Patients with Preserved Ejection Fraction
Authors: Norrina B Allen, Sylvia Badon, Sanjiv J Shah
Journal: Circulation (2014)

Background: Prior studies have shown that high B-type natriuretic peptide (BNP) levels and prolonged QTc intervals are associated with increased mortality, particularly sudden cardiac death, among heart failure (HF) patients. Whether neighborhood socioeconomic status (nSES) impacts BNP or QTc remains unknown. Methods: This study included consecutive patients enrolled from the outpatient clinic of the Northwestern Heart Failure with Preserved Ejection Fraction (HFpEF) Program from June 2007 to November 2010 after hospitalization for HF and followed through May 2011. Patients’ residential addresses were geocoded to identify their census tract of residence. Census 2000 data were used to create a single, summary score of nSES based on residential income, education and employment for each census tract and was divided into tertiles. Outcomes included post-discharge BNP and QTc, obtained within 1 month after HF hospitalization during the outpatient HFpEF clinic visit GEE models were used to examine the association between nSES and BNP and QTc adjusting for age, race, gender, NYHA class, blood pressure, obesity, smoking, glucose, eGFR, and comorbidities. Results: Among the 368 HFpEF patients, 37.0% were female, 50.5% White, avg. age was 64.8 yrs and 45.9% had NYHA class 3+. Higher nSES was significantly associated with lower BNP levels and shorter QTc intervals (Table). The adjusted BNP levels per nSES tertile were 718 pg/mL (±101.4) for the lowest nSES tertile, 508 pg/mL (± 75.3) for the intermediate nSES tertile and 454.2 pg/mL for the highest nSES tertile. Simlarly, QTc interval decreased with increasing tertile of nSES from 464.1 ms (± 5.7) in the lowest nSES tertile to 457.2 ms (± 5.8) and 448.9 ms (± 5.4) for the intermediate and highest tertiles, respectively. Conclusion: Low nSES is associated with increased BNP levels and a longer QTc interval in HFpEF patients. These findings may explain the association of nSES with higher rates of sudden cardiac death and worse outcomes among HF patients in disadvantaged neighborhoods.
Suppression of TGF<sub>β</sub>and Angiogenesis by Type VII Collagen in Cutaneous SCC
Authors: V. L. Martins, M. P. Caley, K. Moore, Z. Szentpetery, S. T. Marsh, D. F. Murrell, M. H. Kim, M. Avari, J. A. McGrath, R. Cerio, A. Kivisaari, V. M. Kähäri, K. Hodivala-Dilke, C. H. Brennan, M. Chen, J. F. Marshall, E. A. O’Toole
Journal: JNCI Journal of the National Cancer Institute (2015)

Background:Individuals with severe generalized recessive dystrophic epidermolysis bullosa (RDEB), an inherited blistering disorder caused by mutations in the COL7A1 gene, develop unexplained aggressive squamous cell carcinomas (SCC). Here we report that loss of type VII collagen (Col7) in SCC results in increased TGFβ signaling and angiogenesis in vitro and in vivo.
Is the Cholesteryl Ester Transfer Protein Proatherogenic or Antiatherogenic in Humans?⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Marina Cuchel, Daniel J. Rader
Journal: Journal of the American College of Cardiology (2007)
Sexual attitudes of hospital personnel: a model for continuing education
Authors: D J Withersty
Journal: American Journal of Psychiatry (1976)

The approach of role playing has been used in the department of behavioral medicine and psychiatry at the West Virginia University Medical Center to help staff persons grow professionally in areas in which factual knowledge is not needed but  an opportunity to review evaluate and perhaps change attitudinal stances may be required. The problem at the West Virginia University Hospital was the discomfort and inadequacy felt by nursing staff when confronted by sexual acting-out. The  nurses requested a program to help them learn to deal with the problem. With the agreement of the nurses it was decided to use behavior rehearsal techniques to alleviate the feelings of discomfort they experience.  At 1st several demonstrations were conducted with groups of between 25-40 people in order to alleviate anxiety. The nursing staff and faculty of the department of behavioral medicine and psychiatry initiated the sessions. Later the  opportunity was offered to practice discussing sexual matters with another professional acting as a patient among smaller groups of from 6 to 8 people. After a number of role-playing situations had been observed the group developed the  following outline of suggested behaviors: 1) the professional should be aware of the 1st hint that a patient wishes to discuss his or her sexual needs and should deal with the issue promptly 2) the professional should make it clear to the  patient that he or she understands that anyone who has been hospitalized for a prolonged period of time would have sexual needs and frustrations 3) the relationship between the professional and the patient should be defined by the  professional in a very clear and unambiguous manner and 4) professionals who find it embarrassing to discuss sexual matters with their patients even after practice sessions should admit their embarrassment to the patient and suggest  willingness to find another professional who does feel comfortable with this issue. The large group demonstrations were well received and the participants indicated that their anxiety about dealing with this particular clinical situation  diminished as they learned and practiced new behaviors for dealing with their own discomfort.