tbuckley/cabot-search huggingface dataset:
Long term follow-up of patient with stage I and II vulvar malignancies evaluated with sentinel lymph node dissections
Authors: R. G. Moore, K. Robison, M. Steinhoff, L. Brard, P. Disilvestro, C. O. Granai
Journal: Journal of Clinical Oncology (2005)

5088 Background: Approximately 5 to 7% of patient with stage I or II squamous cell carcinoma of the vulva will have a groin recurrence after their initial surgical treatment. These recurrences are most often incurable. This study evaluates the inguinal recurrence rates in patients diagnosed with surgical stage I and II squamous cell carcinoma of the vulva treated with sentinel lymph node (SLN) dissection followed by a superficial groin node dissection. Methods: An IRB approved study identified 33 patients with a primary squamous cell carcinoma of the vulva who had undergone a radical vulvectomy with inguinal SLN dissection followed by a superficial groin node dissection. All patients have been followed since their initial treatment to identify inguinal recurrences. Patients who were found to have stage 1 or 2 disease (no inguinal metastasis at the time of initial diagnosis) are included in this analysis. Results: Thirty-three patients were identified as having undergone a radical vulvectomy with SLN dissection followed by a superficial groin dissection. Fourteen patients had surgical stage I disease, 6 had stage II disease, 7 had stage III disease and 6 had stage IV disease. Of the 20 patients with stage I and II disease, 26 groins were evaluated with a SLN dissection (Stage1: 10 unilateral dissection and 4 bilateral dissections, Stage II: 4 unilateral dissections and 2 bilateral dissections). One of 20 patients (5% recurrence rate) was diagnosed with recurrent disease in the inguinal lymph nodes 22 months after initial surgical treatment. Nineteen patients, with 24 groins evaluated, remain with out evidence of inguinal metastasis with a mean follow-up of 32 months (Range of 10 to 55 months). Calculated rate of recurrence is 153/100,000 person-months. Conclusions: Inguinal SLN dissection has been shown to be technically feasible with a low false negative rate. Patients who have undergone a SLN dissection followed by a superficial groin dissection seem to have a decreased or similar rate of recurrent disease within the inguinal lymph nodes than patients with complete inguinal disections. Further studies need to be performed to determine the safety and recurrence rate in patients undergoing SLN dissection alone. No significant financial relationships to disclose.
Hospitalization among United States dialysis patients
Authors: G Habach, W E Bloembergen, E A Mauger, R A Wolfe, F K Port
Journal: Journal of the American Society of Nephrology (1995)

Measurements of hospitalization in the dialysis population are important because they provide insight into the morbidity and the cost of treatment among dialysis patients. Prior comparisons of hospitalization for different dialysis modalities have had conflicting results. This study was designed to compare hospitalization for patients treated with peritoneal dialysis (PD) versus hemodialysis (HD) using the data from the U.S. Renal Data System 1993 Annual Data Report. The study population included all Medicare dialysis patients prevalent on January 1, 1988 through 1990. Patients were monitored to transplantation, death, or end of the calendar year for a total of 189,654 patient years. Hospital admission rates were computed from the total number of hospital admissions during the year divided by the total number of patient years at risk. Patients were classified by treatment modality (PD, HD), cause of ESRD (diabetes as a cause of ESRD versus all other causes), age (0 to 19, 20 to 44, 45 to 65, +65), and race (black, white). Rate ratios (RR:PD/HD) for hospital admissions per year at risk were estimated, while adjusting for the other factors with Poison regression. On average, hospital admission rates per patient year at risk for dialysis patients treated with PD were 14% higher than for those treated with HD (RR = 1.14; 95% confidence interval (Cl), 1.13 to 1.15) when adjusting for race, age, gender, and cause of ESRD. The excess in the overall adjusted admission rates in PD patients compared with HD patients was higher for black than for white patients (RR:PD/HD = 1.22 versus RR = 1.11; 95% Cl, 1.10 to 1.13).(ABSTRACT TRUNCATED AT 250 WORDS)
Missense Mutations in the gp91-phox Gene Encoding Cytochromeb558 in Patients With Cytochrome b Positive and Negative X-Linked Chronic Granulomatous Disease
Authors: Mizuho Kaneda, Hitoshi Sakuraba, Akira Ohtake, Akira Nishida, Chika Kiryu, Katsuko Kakinuma
Journal: Blood (1999)
Treatment of patients with extensive TB and concomitant bronchial lesions with some anti-TB drugs delivered via nebulizer
Authors: Mykhailo Kuzhko, Natalia Hulchuk, Mykola Humeniuk, Lubomir Protsyk
Journal: European Respiratory Journal (2013)

Background.  In patients with extensive TB concomitant bronchial lesions are diagnosed in 16-34% cases. Intravenous infusion of anti-TB drugs allows to create their high concentration in the blood. Additional topical administration of anti-TB drugs via nebulizer may improve the results of treatment.   Materials and Methods:  In case-control study 12 patients with newly diagnosed TB and bronchial lesions were treated with isoniazid (10% solution for infusion), rifamycin SV (30 mg/ml concentrate for infusion) and ethambutol (10% solution for infusion) delivered via intravenous infusions and nebulizer (main group). Pyrazinamide orally and streptomycin in injections were administered to all patients. The comparable patients of control group (n=12) received standard treatment.   Results:  After the intensive phase of treatment in patients of the main group complete resorption of infiltrative changes in bronchi was observed more often by 16.7% versus control. In 2 patients of main group cicatrix stenosis of the degree I was formed, which in the control was diagnosed in 1 patient, and of the degree II and III in 3 patients.   Conclusions:  Adding some anti-TB drugs via nebulizer to intravenous chemotherapy leads to more rapid and complete regression of tuberculous changes in affected bronchi comparing to standard regimen of anti-TB therapy.
Histopathology of Methylbenzylnitrosamine-Induced Esophageal Carcinoma in the Rat: Comparison With Cytomorphology&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: D H Barch, J Walloch, D Hedvegi, P M Iannaccone
Journal: JNCI Journal of the National Cancer Institute (1986)

The incidence of human carcinoma of the esophagus is increased in association with environmental nitrosamines and dietary zinc deficiency. For examination of the role of zinc deficiency in esophageal carcinogenesis, methylbenzylnitrosamine [(MBN) CAS: 937-40-6] was used to induce esophageal carcinoma in rats fed either a zinc-deficient or control diet. Histologic examination of the MBN-treated Sprague-Dawley rat esophagi revealed a significantly higher incidence of esophageal carcinoma in the zinc-deficient rats vs. controls (62 vs. 33%). In addition, three distinct cytologic and histologic patterns were observed in the animals with esophageal carcinoma: pattern I--basal cell hyperplasia, atypical basal cells, few dyskeratotic cells; pattern II--basal cell hyperplasia, atypical basal cells, many dyskeratotic cells; and pattern III--many dyskeratotic cells without basal cell hyperplasia. These three patterns did not occur simultaneously in the same esophagi, and zinc deficiency did not alter the appearance of these patterns. A strong correlation between the appearance of moderate or severe dysplasia cytologically and microinvasive carcinoma histologically was demonstrated. In those animals with histologically evident microinvasive carcinoma, there was no cytologic evidence of carcinoma in situ or invasive carcinoma. Cytology of these esophageal carcinomas revealed only moderate or severe dysplasia. To the extent that the rat model represents the evolution of esophageal carcinoma in humans, the results presented here suggest that the cytologic appearance of moderate or severe dysplasia indicates the need for further evaluation of patients at risk for esophageal carcinoma.
Chemotherapy-induced thymidine phosphorylase modulation in colorectal cancer
Authors: G. Aprile, M. Miscoria, P. Baldin, A. Casetta, M. Pandolfi, C. Di Loreto, S. Pizzolitto, S. Pizzolitto, L. Foltran, G. Fasola, F. Puglisi
Journal: Journal of Clinical Oncology (2009)

e15050 Background: Thymidine phosphorylase (TP) is an inducible enzyme responsible for nucleoside metabolism, antiapoptosis activity, and promotion of angiogenesis. In addition, conversion of the prodrug capecitabine (C) to its active form depends on TP activity. Preliminary evidence suggests that TP immunohistochemical expression may predict benefit from first-line treatment of metastatic colorectal cancer (CRC) with C plus irinotecan. Several chemotherapeutic agents have been shown to modulate TP expression. The aim of the present analysis was to verify if TP expression differs among primary and paired metastases in CRC patients, or may vary depending on patients’ exposure to chemotherapy. Methods: TP expression was evaluated by immunohistochemistry (clone p-P-GF.44C, Abcam, Cambridge, UK) in a series of 120 primary CRC and their matched distant metastases. Tsuda's scoring system was adopted, defining TP expression as negative (score 0–1) or positive (score 2–3). Results: Data on the first 57 patients are here presented. Sites of biopsied metastases were liver (n=41), lung (n=10), and peritoneum (n=6). Metastases were asynchronous in 42% of patients. Higher TP expression was observed in primary cancers than in metastases (36.8% vs. 15.8%, p=0.007). Among patients who received at least one cycle of chemotherapy before metastasis sampling (38.6%), a TP expression decrease was demonstrated in only 13% of metastatic samples. Oppositely, a significantly higher proportion of untreated patients lost TP expression in metastasis sites (36%, p=0.01). Conclusions: In advanced CRC patients, TP expression tend to decrease in metastases, particularly in those patients who did not receive chemotherapy before metastatic sampling. Although intratumoral heterogeneity and other causes of discrepancy cannot be excluded, true chemotherapy-induced modulation of TP may be hypothesized. No significant financial relationships to disclose.
Acute leukemia and pregnancy.
Authors: A Avilés
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.3.560 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3351561 Acute leukemia and pregnancy. A AvilésxA AvilésSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.3.560 PDF "Acute leukemia and pregnancy.." Journal of Clinical Oncology, 6(3), pp. 560–561© 1988 by American Society of Clinical Oncology
Human Leukemia Cell Antigens: Serologic Characterization With Xenoantisera2
Authors: T. Mohanakumar, R. S. Metzgar, D. S. Miller
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Human Leukemia Cell Antigens: Serologic Characterization With Xenoantisera Get access T. Mohanakumar, T. Mohanakumar Department of Microbiology and Immunology, Duke University Medical Center, Durham, N.C. 27710 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. S. Metzgar, R. S. Metzgar 4 Department of Microbiology and Immunology, Duke University Medical Center; and Yerkes Primate Research Center, Emory University, Atlanta, Ga. 30322 4Address reprint request and editorial comments to: Dr. Metzgar at Duke University Medical Center. Search for other works by this author on: Oxford Academic PubMed Google Scholar D. S. Miller D. S. Miller Department of Medicine, Duke University Medical Center Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 5, May 1974, Pages 1435–1444, https://doi.org/10.1093/jnci/52.5.1435 Published: 01 May 1974 Article history Received: 15 November 1973 Accepted: 10 February 1974 Published: 01 May 1974
Prevalence of Sensitization to Mold Allergens in Patients with Respiratory Allergy
Authors: Barbara Elizondo-Villarreal, Sandra N. Gonzalez-Diaz, Alfredo Arias-Cruz, Lucia Leal-Villarreal, Maria Del Carmen Zarate-Hernandez, Dulce M. Rivero-Arias, Olga P. Monge Ortega, Jesus A. Ibarra-Chavez
Journal: Journal of Allergy and Clinical Immunology (2016)
Abstract P251: The Impact of Clinical Risk Factors on Risk of Peripheral Arterial Disease in Men
Authors: Michel M Joosten, Jennifer K Pai, Eric B Rimm, Donna Spiegelman, Murray A Mittleman, Kenneth J. Mukamal
Journal: Circulation (2012)

Background: Previous studies have examined individual risk factors in relation to peripheral arterial disease (PAD) but the combined effects of these factors are largely unknown. We investigated the degree to which clinical risk factors may explain the risk of PAD among men. Methods: We prospectively followed 45,596 men from the Health Professional Follow-up Study without a history of cardiovascular disease at baseline during a 22-year period (1986–2008). We defined four clinical risk factors - smoking, history of type 2 diabetes, hypertension, and hypercholesterolemia - that were updated biennially during follow-up. Cox proportional hazard models were used to compare PAD risk across individual and joint risk factors. Results: During 874,769 person-years of follow-up, 497 confirmed PAD cases occurred. All four clinical risk factors were significantly and independently associated with a higher risk of PAD after multivariate adjustment (Figure). Risk of PAD more than doubled (hazard ratio: 2.14; 95% confidence interval [95% CI]: 1.95–2.35) for each additional risk factor compared with the group free of risk factors. Men without any of the four risk factors had a relative risk of PAD of 0.19 compared with all other men (95% CI: 0.11–0.31). In 96.8% (95% CI: 95.2–98.3%) of the PAD cases, at least one of the four risk factors was present. Overall, 8 out of 10 cases of PAD appeared to be attributable to these four conventional risk factors. Conclusion: The great majority of PAD can be explained by four conventional risk factors. Figure legend: Hazard ratios for incident peripheral arterial disease (PAD) according to individual and joint risk factors. Hazard ratios are adjusted for age, height, aspirin use, family history of myocardial infarction before age 60 y, geographical region, body mass index, physical activity, alcohol consumption (and each of the other three binary clinical risk factors in the individual risk factor analyses).
Differentially Expressed Genes and Pathways in Endothelial Cells Exposed to Hemin or Plasma from Patients with Sickle Cell Disease: A Meta-Analysis of Gene Expression Studies
Authors: Maiara M L Fiusa, Marina Pereira Colella, Joyce M Annichino-Bizzacchi, Loredana Nilkenes, Bidossessi W Hounpke, Sara T O Saad, Fernando Ferreira Costa, Erich Vinicius De Paula
Journal: Blood (2014)
The History, Status, Gaps, and Future Directions of Neurotoxicology in China
Authors: Tongjian Cai, Wenjing Luo, Diyun Ruan, Yi-Jun Wu, Donald A. Fox, Jingyuan Chen
Journal: Environmental Health Perspectives (2016)

Background:Rapid economic development in China has produced serious ecological, environmental, and health problems. Neurotoxicity has been recognized as a major public health problem. The Chinese government, research institutes, and scientists conducted extensive studies concerning the source, characteristics, and mechanisms of neurotoxicants.Objectives:This paper presents, for the first time, a comprehensive history and review of major sources of neurotoxicants, national bodies/legislation engaged, and major neurotoxicology research in China.Methods:Peer-reviewed research and pollution studies by Chinese scientists from 1991 to 2015 were examined. PubMed, Web of Science and Chinese National Knowledge Infrastructure (CNKI) were the major search tools.Results:The central problem is an increased exposure to neurotoxicants from air and water, food contamination, e-waste recycling, and manufacturing of household products. China formulated an institutional framework and standards system for management of major neurotoxicants. Basic and applied research was initiated, and international cooperation was achieved. The annual number of peer-reviewed neurotoxicology papers from Chinese authors increased almost 30-fold since 2001.Conclusions:Despite extensive efforts, neurotoxicity remains a significant public health problem. This provides great challenges and opportunities. We identified 10 significant areas that require major educational, environmental, governmental, and research efforts, as well as attention to public awareness. For example, there is a need to increase efforts to utilize new in vivo and in vitro models, determine the potential neurotoxicity and mechanisms involved in newly emerging pollutants, and examine the effects and mechanisms of mixtures. In the future, we anticipate working with scientists worldwide to accomplish these goals and eliminate, prevent and treat neurotoxicity.Citation:Cai T, Luo W, Ruan D, Wu YJ, Fox DA, Chen J. 2016. The history, status, gaps, and future directions of neurotoxicology in China. Environ Health Perspect 124:722–732; http://dx.doi.org/10.1289/ehp.1409566
부분 간절제술로 급성 간부전이 유도된 흰쥐에서 동종 동결간세포의 비장내 이식의 효과
Authors: 황성규(Seong Gyu Hwang), 윤익진(Ik Jin Yun), 김연수(Yun Soo Kim), 김경철(Kyung Chul Kim), 홍성표(Sung Pyo Hong), 박필원(Pil Won Park), 임규성(Kyu Sung Rim), 조주영(Joo Young Cho), 이준성(Joon Seong Lee), 이문성(Moon Sung Lee), 심찬섭(Chan Sup Shim)
Journal: Clinical and Molecular Hepatology (1999)

Background/Aims : Various techniques of hepatocyte transplantation were actively studied as an alternative to liver transplantation, because of the difficulty of obtaining donor organ, technical difficulties, and high cost. Isolated hepatocytes could be appropriately banked and distributed on demand. We tried to investigate the effect of intrasplenic transplantation of allogenic cryopreserved hepatocytes, into spleen prior to 90% partial hepatectomy in rats, on the survival rate. Methods : Cryopreserved hepatocytes, isolated by collagenase perfusion of the liver via the portal vein, were thawed and transplanted into the spleen of rats prior to induction of acute hepatic failure by resection of all lobes except caudate lobe (2.0×107 hepatocytes/rat). Results : 1. The viability of freshly isolated hepatocyte was 70-85%, but cell viability after cryopreservation 30-50%. 2. Difference of survival in control and transplant group is not statistically significant. but the survival rate, 48 hours after 90% partial hepatectomy, for control (7) and transplanted group (11) were 0% and 18%, respectively. 3. Although the glucose reduction gradient was not significantly different between two groups, it was more prominent in the control group than in the transplanted group. 4. Engraftment and survival of transplanted hepatocytes were noted in the spleen 2 days after transplantation. Conclusions : We could not observe statistically significant improvement of survival with intrasplenic transplantation of cryopreserved hepatocytes in rats with 90% partial hepatectomy-induced acute liver failure. However, 18% survival after 90% partial hepatectomy was noted in the transplanted group, compared to no survival in the control group. This suggests that intrasplenic transplantation of cryopreserved hepatocytes might be effective in the treatment of acute liver failure. (Korean J Hepatol 1999;5:116－123)
Efficacy of PS-341 in combination with paclitaxel (PAC) and carboplatin (CBDCA) for the treatment of metastatic melanoma (MM): A phase II consortium study
Authors: W. J. Maples, V. Suman, G. A. Croghan, M. R. Albertini, G. Linette, L. E. Flaherty, J. Eckardt, T. Amatruda, C. E. Erlichman
Journal: Journal of Clinical Oncology (2008)

20012 Background: Chemotherapyhas no significant impact on survival of MM. The potential synergy of PS-341 with PAC and CBDCA was hypothesized in a phase I trial (Ma C et al Cancer Chemother Pharmacol.59:207; 2007) Methods: Eligibility required measurable disease, < 2 prior chemotherapies, ECOG 0–2, adequate organ function, no CNS metastases, <3 immunotherapy regimens. Treatment included PS-341 1.3 mg/m2 IV d1,4,8 and PAC 175 mg/m2 and CBDCA AUC 6 d2 every 21 days. A two stage design was used to assess if tumor response rate (TRR) ≥35%. If <4 of first 19 patients enrolled had a tumor response (PR or CR by RECIST), the trial was to be closed. Results: 19 patients were enrolled (71% male, 53% PS0, no prior therapy 18%); one was deemed to be ineligible and a second patient cancelled prior to beginning treatment. A median of 3 cycles were administered (range 1–6). Grade 3/4 toxicities included neutropenia (71%), leukopenia (41%), thrombocytopenia (29%), and arthralgia (12%). Two partial responses were observed (TRR 11.8%). 4 patients had stable disease > 12 weeks. The median PFS was 3.2 months and the median survival 6.2 months. Due to the lack of efficacy and significant toxicity the trial did not proceed to the second stage. Conclusion: The combination of PAC + CBDCA + PS341 demonstrated limited activity with significant toxicity. Supported by NCI N01 CM62205 No significant financial relationships to disclose.
BTS recommendations for referral for hypoxic flight assessment are not appropriate in paediatrics
Authors: Patrick Jamieson, Colleen Carden
Journal: European Respiratory Journal (2012)

Introduction 

The assessment of paediatric hypoxia during commercial flight is not as well understood as the equivalent area in adults. The BTS recommends that patients with a baseline greater than 95% do not need a hypoxic flight assessment. This study examined the BTS criteria for referral for hypoxic flight assessment with respect to prevalence of hypoxia during this assessment, in a paediatric sample.

Methods 

This was a retrospective audit of patients referred to a paediatric respiratory function laboratory. The test protocol used 100% nitrogen to dilute the contents of a body plethysmograph to a FiO2 of 15%, before assessing the SpO2 profile for 20 minutes. Failure of hypoxic challenge, according to BTS criteria, constituted a mean SpO2% of less than 90% when breathing FiO2 15%.

Results 

107 children (58% female) age 0.1-19.2 years (mean 7.0, SD 5.4) were tested. They were referred for a variety of conditions including muscular dystrophy, cystic fibrosis, severe asthma, long term ventilation, long term oxygen therapy and sleep breathing disorders. 83% of patients referred had a baseline SpO2 in FiO2 21% of greater than 95%. 29% of these patients were determined to be hypoxic in FiO2 15%.

Conclusions 

If BTS criteria for referral were applied to this patient sample, only 6% would be detected as hypoxic in FiO2 15%. When these criteria are not used then a total of 35% of these patients are found to be hypoxic. Either the BTS criteria for detecting hypoxia are too sensitive, or the BTS indications for hypoxic flight assessment are not specific enough. This study highlights the problems associated with predicting a patient's response to hypoxia using baseline measures.
Crizotinib in Patients with Lung Cancer and Ros1 Fusion: Results from the European Cohort Euros1.
Authors: J. Mazières, G. Zalcman, L. Crinò, P. Biondani, T. Filleron, A.C. Dingemans, H. Lena, I. Monnet, S.I. Rothschild, F. Cappuzzo, L. Thiberville, F. Barlesi, R. Dziadziuszko, E.F. Smit, J. Wolf, C. Spirig, N. Pecuchet, J. Diebold, J. Milia, O. Gautschi
Journal: Annals of Oncology (2014)