tbuckley/cabot-search huggingface dataset:
Establishment and Characterization of HUOT, a Human Ovarian Malignant Teratoma Cell Line Producing α-Fetoprotein
Authors: I Ishiwata, C Ishiwata, M Soma, K Tomita, S Nozawa, H Ishikawa
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Establishment and Characterization of HUOT, a Human Ovarian Malignant Teratoma Cell Line Producing α-Fetoprotein Get access Isamu Ishiwata, Isamu Ishiwata Search for other works by this author on: Oxford Academic PubMed Google Scholar Chieko Ishiwata, Chieko Ishiwata Search for other works by this author on: Oxford Academic PubMed Google Scholar Masayuki Soma, Masayuki Soma Search for other works by this author on: Oxford Academic PubMed Google Scholar Kano Tomita, Kano Tomita Search for other works by this author on: Oxford Academic PubMed Google Scholar Shiro Nozawa, Shiro Nozawa Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroshi Ishikawa Hiroshi Ishikawa Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 75, Issue 3, September 1985, Pages 411–422, https://doi.org/10.1093/jnci/75.3.411 Published: 01 September 1985 Article history Received: 15 March 1984 Revision received: 12 May 1985 Accepted: 06 June 1985 Published: 01 September 1985
Reversal of Wasting Syndrome in Thymectomized Mice by Multiple Syngeneic or Allogeneic Thymus Grafts&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Robert T. Schaller, Jr., Jane Schaller, John K. Stevenson
Journal: JNCI Journal of the National Cancer Institute (1967)

Restoration of normal immunologic development with reversal of wasting syndrome is described in wasted thymectomized mice receiving multiple grafts of newborn syngeneic or allogeneic thymus. Recovered mice showed normal development of lymphoid tissues and immunologic capacity as measured by homograft rejection and graft-versus-host reactivity of spleen cells. Twenty-three of thirty-five wasted mice receiving five syngeneic thymus grafts recovered. In contrast, only 2 of 15 given single syngeneic thymus grafts recovered, whereas 9 of 15 survived with persistent wasting, lymphoid hypoplasia, and immune deficiency. Sixteen of thirty wasted mice receiving multiple allogeneic thymus grafts recovered. When host and donor shared the same H-2 locus, 12 of 14 recovered; 9 of these 12 became cellular chimeras with the thymus donor strain. When host and donor differed at the H-2 locus, only 4 of 16 mice recovered and only host-type immunocompetent cells were demonstrable. These experiments indicated that thymus grafts restored immune capacity and permitted reversal of wasting by 1) stimulating development of the host's lymphoid system (humoral), 2) donating lymphoid cells to the host (cellular), or 3) a combination of both mechanisms. With allogeneic thymus grafts, both humoral and cellular mechanisms seemed to contribute if host and donor shared the H-2 locus, whereas humoral mechanisms alone may have been operative in mice grafted with thymus across the H-2 barrier. Multiple thymus grafts were more effective in reversing wasting syndrome than were single thymus grafts, probably because they presented greater humoral stimulation and more lymphoid cells to the host's lymphoid system.
Abstract 306: A Novel PKCalpha Splicing Isoform in Signaling for Cardiac Hypertrophy
Authors: CHEN GAO, Jianli Gong, Susan F Steinberg, Yibin Wang
Journal: Circulation Research (2014)

RNA splicing is a significant post-transcriptional regulatory step to enrich the overall transcriptome complexity, yet its specific contribution to cardiac development and pathogenesis remains underexplored. Here, we performed a comprehensive deep RNA-seq analysis in murine heart to investigate the cardiac transcriptome at single exon-resolution. From the dataset, we have identified a previously un-annotated novel exon in the PKCα transcript ---PKCα-NE (Novel Exon). The novel exon encode a 16 amino acid insert adjacent to the PKCα turn motif. Interestingly, the splicing event is detected only in cardiac and skeletal muscle. Based on bioinformatics analysis, we have identified two highly conserved binding motifs for a cardiac splicing regulator_RBFox1. We further demonstrated that RBFox1 indeed functions as a positive regulator for the splicing event of this novel exon. In vitro studies showed that the NE converts PKCα from a lipid-dependent enzyme to a constitutively active kinase with high levels of autocatalytic activity and activity toward peptide substrates. The NE also increases PKCα’s Km for peptide substrate. These changes in steady state kinetic parameters suggest that PKCα-NE would exert it’s cellular actions most prominently when co-localized with target substrates, either on protein scaffolds or in subcellular signaling compartments. In fact, immune-precipitation for individual PKCα spicing variants followed by Mass Spectrometry exposed a specific interaction between PKCα-NE and elongation factor (eEF1A1). PKCα-WT and PKCα-NE both stimulated cardiac hypertrophy to a similar level based on myocyte size measurement, but PKCα-NE selectively increased eEF1A1 phosphorylation in association with elevated protein translational activity in cultured cardiomyocytes. In summary, we have identified a novel cardiac specific splicing variant of PKCα that is dynamically regulated during development and heart failure. Our finding has revealed a novel signaling pathway in cardiac hypertrophy involving a novel alternative splicing event of PKCα and its specific downstream effects on protein synthesis regulation.
Antioxidants and Cancer. I. Selenium in the Blood of Normals and Cancer Patients
Authors: R. J. Shamberger, E. Rukovena, A. K. Longfield, S. A. Tytko, S. Deodhar, C. E. Willis
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Antioxidants and Cancer. I. Selenium in the Blood of Normals and Cancer Patients Get access R. J. Shamberger, R. J. Shamberger The Department of Biochemistry, The Cleveland Clinic Foundation and the Cleveland Clinic Educational Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106 Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Rukovena, E. Rukovena The Department of Biochemistry, The Cleveland Clinic Foundation and the Cleveland Clinic Educational Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106 Search for other works by this author on: Oxford Academic PubMed Google Scholar A. K. Longfield, A. K. Longfield The Department of Biochemistry, The Cleveland Clinic Foundation and the Cleveland Clinic Educational Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106 Search for other works by this author on: Oxford Academic PubMed Google Scholar S. A. Tytko, S. A. Tytko The Department of Biochemistry, The Cleveland Clinic Foundation and the Cleveland Clinic Educational Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106 Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Deodhar, S. Deodhar The Department of Biochemistry, The Cleveland Clinic Foundation and the Cleveland Clinic Educational Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106 Search for other works by this author on: Oxford Academic PubMed Google Scholar C. E. Willis C. E. Willis The Department of Biochemistry, The Cleveland Clinic Foundation and the Cleveland Clinic Educational Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 50, Issue 4, April 1973, Pages 863–870, https://doi.org/10.1093/jnci/50.4.863 Published: 01 April 1973 Article history Received: 23 August 1972 Accepted: 08 January 1973 Published: 01 April 1973
A Randomized Trial to Assess the Efficacy and Safety of ABT-126, a Selective α7 Nicotinic Acetylcholine Receptor Agonist, in the Treatment of Cognitive Impairment in Schizophrenia
Authors: George M. Haig, Earle E. Bain, Weining Z. Robieson, Jeffrey D. Baker, Ahmed A. Othman
Journal: American Journal of Psychiatry (2016)

The authors sought to evaluate the efficacy and safety of ABT-126, a selective α7 nicotinic receptor partial agonist, in stable patients with schizophrenia.A 12-week, double-blind, placebo-controlled, parallel-group phase 2 study was conducted in 22 centers in the United States. Clinically stable patients with schizophrenia were randomly assigned to receive once-daily dosing with 10 mg of ABT-126, 25 mg of ABT-126, or placebo. The primary efficacy measure was change from baseline to week 12 on the MATRICS Consensus Cognitive Battery (MCCB) composite score compared with placebo, tested by a one-sided t test. Secondary measures included MCCB domain scores and UCSD Performance-Based Skills Assessment total score, each tested by two-sided t tests.A total of 207 subjects were randomized, of whom 165 (81%) completed the study. ABT-126 showed an improvement that fell short of significance on the MCCB composite score at week 12 (least squares mean difference from placebo, 1.3 and 1.5 for the 10 mg and 25 mg groups, respectively). A significant treatment-by-smoking status interaction was observed on the mean change from baseline to final MCCB composite score: nonsmokers (N=69) demonstrated a difference from placebo of 2.9 (SE=1.4) in the 10 mg group and 5.2 (SE=1.6) in the 25 mg group, whereas no differences were observed in smokers (N=113). Among the nonsmokers in the ABT-126 25 mg group (N=19), significant improvements compared with placebo occurred at final assessment for verbal learning (least squares mean difference=5.5, SE=1.9), working memory (least squares mean difference=5.4, SE=2.0), and attention/vigilance (least squares mean difference=8.7, SE=2.5). The most frequently reported adverse events for ABT-126 were dizziness, diarrhea, and fatigue (all <8% incidence).ABT-126 demonstrated a procognitive effect in nonsmoking subjects, particularly in verbal learning, working memory, and attention.
Quantitative Study on Foci of Altered Liver Cells Induced in the Rat by a Single Dose of Diethylnitrosamine and Partial Hepatectomy&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: E. Scherer, M. Hoffmann, P. Emmelot, M. Friedrich-Freksa
Journal: JNCI Journal of the National Cancer Institute (1972)

After a single dose of 10 mg diethylnitrosamine/kg rat, foci of liver cells changed in adenosine triphosphatase, glucose-6-phosphatase, cytoplasmic basophilia, and glycogen storage. A method for the quantitation of the number and size distribution of these foci was derived. The number of adenosine triphosphatase-deficient lesions was increased five-fold to tenfold by partial hepatectomy 20–24 hours before application of the carcinogen. The number of lesions remained constant from 6 weeks to 8 months after induction, but the continuous increase in size suggested a certain autonomy of growth. Two phases of different growth rate could be distinguished. At the end of the 8-month experiment, about 4% of the liver tissue consisted of altered liver cells. The results may be related to the general problem of hepatocarcinogenesis, since the observed changes are also found in liver treated with other hepctoccrcincgens, and the changed cells could be tumor-cell precursors.
The Potential Diagnostic Role of Procalcitonin for Bacteremia in a Large Cohort of Solid Cancer Patients
Authors: I. Fioroni, B. Vincenzi, A. Zoccoli, S. Angeletti, L. De Florio, D. Santini, G. Dicuonzo, A. Picardi, M. Caricato, G. Tonini
Journal: Annals of Oncology (2014)
Leucovorin calcium enhancement of mucositis after continuous infusion fluorouracil and short infusion cisplatin.
Authors: F Figoli, V Chiarion Sileni, M Gulisano, P Maggian, V Fosser
Journal: Journal of Clinical Oncology (1989)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1989.7.5.680 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2785166 Leucovorin calcium enhancement of mucositis after continuous infusion fluorouracil and short infusion cisplatin. F FigolixF FigoliSearch for articles by this author , V Chiarion SilenixV Chiarion SileniSearch for articles by this author , M GulisanoxM GulisanoSearch for articles by this author , P MaggianxP MaggianSearch for articles by this author , V FosserxV FosserSearch for articles by this author Show More Hamilton Regional Cancer Centre, Hamilton, Canada. https://doi.org/10.1200/JCO.1989.7.5.680 PDF "Leucovorin calcium enhancement of mucositis after continuous infusion fluorouracil and short infusion cisplatin.." Journal of Clinical Oncology, 7(5), pp. 680–681© 1989 by American Society of Clinical Oncology
Computing the Internode Certainty and Related Measures from Partial Gene Trees
Authors: Kassian Kobert, Leonidas Salichos, Antonis Rokas, Alexandros Stamatakis
Journal: Molecular Biology and Evolution (2016)

We present, implement, and evaluate an approach to calculate the internode certainty (IC) and tree certainty (TC) on a given reference tree from a collection of partial gene trees. Previously, the calculation of these values was only possible from a collection of gene trees with exactly the same taxon set as the reference tree. An application to sets of partial gene trees requires mathematical corrections in the IC and TC calculations. We implement our methods in RAxML and test them on empirical datasets. These tests imply that the inclusion of partial trees does matter. However, in order to provide meaningful measurements, any dataset should also include trees containing the full species set.
Abstract MP71: Undetected Disease and Low Medication Adherence are Major Determinants of Poor Cardiovascular Risk Factor Control in Rural India
Authors: Aditya K Khetan, Raghunandan Purushothaman, Rishab Gupta, Sushil Agarwal, Sri Krishna Madan Mohan, Richard A Josephson
Journal: Circulation (2016)

Background: Cardiovascular disease is the leading cause of mortality in India. Since it is largely driven by risk factors such as hypertension, diabetes and smoking it is important to study diagnosis, treatment and control patterns for these conditions, and identify areas for improvement. Methods: Project SEHAT (ClinicalTrials.gov number, NCT02115711) is a cluster RCT with a long term goal of improving the control of cardiovascular risk factors in a rural community in West Bengal, India. For the baseline data, 3575 adults, between the ages of 35 and 70, were screened for hypertension, diabetes and smoking. For hypertension and diabetes, an elevated reading was confirmed on a repeat visit. Results: Risk factors were common, with hypertension, diabetes and smoking evident in 18.3% (654 of 3575), 9.0% (321 of 3575) and 15.1% (540 of 3575) of adults, respectively. Overall, 34.5% (1233 of 3575) of adults had at least one risk factor. There was a huge burden of undetected disease, with only 45.2% (296 of 654) of hypertensives and 59.8% (192 of 321) of diabetics previously aware of their disease. Linkage to care was high with 72.0% (213 of 296) of previously diagnosed hypertensives and 86.0% (165 of 192) of previously diagnosed diabetics on treatment. Control rates were, however, low with 8.2% (54 of 654) of hypertensives controlled (BP &lt;140/90 mmHg) and 13.7% (44 of 321) of diabetics controlled (fasting blood sugar &lt;126 mg/dl). This may be partly explained by a low medication adherence rate, with the adherence (medium and high) being 35.5% (76 of 213) in hypertensives and 20.6% (34 of 165) in diabetics, as measured by the Morisky Medication Adherence Scale-8. Conclusions: In our population in rural India, 1 in 3 adults have a major cardiovascular risk factor, with abysmal control rates. Barriers to risk factor control primarily exist at the points of diagnosis and medication adherence. Over the next 2 years, a community health worker led intervention, with an aim to improve the control of hypertension, diabetes and smoking will be tested in this cohort.
Abstract P4-02-12: Breast MRI: Enhancing pre-operative planning in women with newly diagnosed breast cancer
Authors: B Carr, LC Lamb, K Zarfos, J Weigert, R Singh
Journal: Cancer Research (2016)

Abstract Hypothesis: Preoperative breast MRIs in newly diagnosed breast cancer patients may lead to additional findings, including larger disease involvement, thus leading to a change in the operative plan. This information can led to better surgical planning and decreased rates of surgical re-excisions. Methods: This was a single surgeon, single institution, retrospective analysis of women with newly-diagnosed breast cancer who had surgery between December 2013 and December 2014. A total of ninety-six patients underwent preoperative breast MRI. Exclusion criteria were patient's refusal of MRI or surgery, contraindication to MRI based on implants or body habitus, and male patients. Results: Overall, breast MRI most closely correlated to pathological tumor size (gold standard). MRI had a 64% correlation with pathology size, whereas mammography and ultrasound correlation were 44% and 43% respectively. As breast density increased, MRI correlation to pathologic tumor size improved. For breast density between 25-50%, tumor size by MRI correlated with pathology size in 27% of patients, mammogram correlation was 33% and ultrasound was 12%. When breast density increased to 51-75%, MRI correlation improved to 92%, whereas mammogram correlation was 56% and ultrasound was 68%. The majority of patients fell within these two density categories; correlation for breast density &amp;lt;25% and &amp;gt;75% were not statistically significant. Of the breast biopsies preformed for MRI abnormalities not otherwise identified by mammography or ultrasound, 42% were positive for invasive cancer or DCIS. Thirty-eight percent of patients had a change in operative plan based on their MRI findings. Of the ninety-six patients, nine were changed from breast conserving surgery to mastectomy, and 29 underwent a larger area of resection than planned prior to MRI, due to findings of more extensive disease on MRI not otherwise appreciated by mammography or ultrasound. Conclusion: Pre-operative MRI played a significant role in the pre-surgical evaluation of patients with newly diagnosed breast cancer. In our series, breast MRI demonstrated better correlation with extent of disease compared to other imaging modalities. This is turn enhanced patient and surgeon decision making and led to more precise pre-operative surgical planning. Citation Format: Carr B, Lamb LC, Zarfos K, Weigert J, Singh R. Breast MRI: Enhancing pre-operative planning in women with newly diagnosed breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-02-12.
Osteoarthritis
Authors: Allan C. Gelber
Journal: Annals of Internal Medicine (2014)

This article has been corrected. The original version (PDF) is appended to this article as a Supplement. This issue provides a clinical overview of Osteoarthritis focusing on prevention, diagnosis, treatment, practice improvement, and patient information. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including ACP Smart Medicine and MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic from these primary sources in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of science writers and physician writers. Editorial consultants from ACP Smart Medicine and MKSAP provide expert review of the content. Readers who are interested in these primary resources for more detail can consult http://smartmedicine.acponline.org, https://mksap.acponline.org/, and other resources referenced in each issue of In the Clinic.
Types Band C RNA Virus in Breast Tissue and Milk of Wild Mice2
Authors: Robert W. Rongey, Alena Hlavackova, Stephanie Lara, John Estes, Murray B. Gardner
Journal: JNCI Journal of the National Cancer Institute (1973)

Type B virus particles were found by electron microscopy in prelactating breast tissue and milk samples from many recently trapped pregnant wild mice from 3 trapping areas in southern California. Type C virus particles and the corresponding complement-fixing group-specific (gs) antigen were found in low incidence in prelactating breast and spleen tissues of mice from 2 of these areas. However, wild mice from the third trapping area showed a high prevalence of type C particles and gs antigen in these tissues and type C particles in milk. An increased incidence of spontaneous breast tumors, as well as lymphomas, was observed in nonpregnant female wild mice from this third trapping area.
Superiority of carbohydrate-deficient transferrin to gamma- glutamyltransferase in detecting relapse in alcoholism
Authors: L G Schmidt, K Schmidt, P Dufeu, A Ohse, H Rommelspacher, C Müller
Journal: American Journal of Psychiatry (1997)

Objective: The usefulness of carbohydrate-deficient transferrin is widely accepted in screening (male) population samples for heavy alcohol consumption, but its role in relapse detection is not convincingly established.The authors therefore compared the diagnostic value of carbohydrate-deficient transferrin with the commonly used γ-glutamyltransferase in identifying relapsed alcoholics during outpatient aftercare.Method: The patients were 101 male alcoholics who entered a 6-month rehabilitation program after hospital detoxification.Drinking status was assessed by means of self-and collateral reports obtained during regular contacts with the rehabilitation team; relapse was defined as consumption of any alcohol.Visits occurred weekly during month 1, biweekly during month 2, and every 4 weeks during months 3-6.At every visit a blood sample was taken for measurement of carbohydrate-deficient transferrin and γ-glutamyltransferase.Results: The proportion of men who reported relapse was 25.6% per scheduled contact on average.Positive predictive values indicated that relapse was identified with a 76.2% probability by carbohydrate-deficient transferrin values above the upper normal limit, in contrast to a 32.9% chance with γ-glutamyltransferase.Carbohydrate-deficient transferrin was especially useful in detecting early relapses during the initial rehabilitation phase, when γ-glutamyltransferase values had not normalized.Because of the longer half-life of γ-glutamyltransferase, it had some value with a 4-week monitoring schedule in detecting new drinking episodes in alcoholics whose previous results had been normal.Conclusions: Carbohydrate-deficient transferrin proved to be superior to γ-glutamyltransferase in relapse detection in an outpatient care setting for alcoholics.
A Phase II Study of Pmab + Iri for Mcrc Pts with Wildkras, Resistant to Fluoropyrimidine, Oxaliplatin and Iri(Ogsg1001)
Authors: Hiroko Hasegawa, Motoki Yoshida, Koichi Taira, Naotoshi Sugimoto, Takayuki Kii, Kouji Takeda, Tetsuhiro Yoshinami, Daisuke Sakai, Taroh Satou, Hiroshi Furukawa
Journal: Annals of Oncology (2014)