tbuckley/cabot-search huggingface dataset:
Ziv-aflibercept in combination with FOLFIRI for second-line treatment of patients with metastatic colorectal cancer (mCRC): Interim safety data from the global aflibercept safety and quality-of-life program (ASQoP and AFEQT studies) in patients ≥65.
Authors: Roberto Bordonaro, Alberto F. Sobrero, Luca Frassineti, Libero Ciuffreda, Giuseppe Aprile, Anne L. Thomas, Yan Moore, Chiara Zilocchi, Emmanuelle Dochy, Julien Taïeb, David Raymond Ferry
Journal: Journal of Clinical Oncology (2014)

545 Background: The prespecified analysis of patients ≥65 years of age in the VELOUR study demonstrated a safety profile similar to that of ziv-aflibercept (Z) (known as aflibercept outside the United States) plus FOLFIRI in the overall VELOUR study. Results from VELOUR supported the initiation of the global Aflibercept Safety and Quality-of-Life (QoL) Program composed of two clinical studies (ASQoP [NCT01571284]; AFEQT [NCT01670721]) to capture QoL and safety data from a target population similar to that of VELOUR in a real-life setting. We report early safety data from this interim analysis for patients ≥65 y. Methods: ASQoP and AFEQT are single-arm, open-label trials evaluating safety and QoL of Z in mCRC patients previously treated with an oxaliplatin-containing regimen. Eligible patients received Z (4 mg/kg) q2wks on day 1 of each cycle followed by FOLFIRI until disease progression, unacceptable toxicity, death, or investigator/patient decision. Initial starting doses and subsequent dose modifications are at the treating physician’s discretion. The percentage of patients ≥65 y with grade (G) 3/4 adverse events (AEs) in the combined safety population of ASQoP and AFEQT are compared with that of the prespecified analysis in patients ≥65 y from VELOUR. Results: At data cut-off, the safety population comprised 116 patients with at least 1 completed cycle of treatment; 53 (45.7%) were ≥65 y. At least 1 G3/4 AE was experienced by 64.2% of patients vs 89.3% in VELOUR. Most reported G3/4 AEs were G3. There were no reports of G4 hypertension, diarrhea, stomatitis, or proteinuria. Conclusions: Thisinterim safety analysis from ASQoP and AFEQT in patients ≥65 y has identified no new safety signals. The early interim analysis provides additional safety data and suggests an acceptable toxicity profile in this real-life setting. Clinical trial information: NCT01571284. [Table: see text]
Abstract 17579: Quantification of Femoral Adipose Tissue Provides Novel Mechanistic Insights Into the "Obesity Paradox": a Translational Approach
Authors: Alexios S Antonopoulos, Marios Margaritis, Laura Herdman, Patricia Coutinho, Constantinos Psarros, Janet Digby, George Krasopoulos, Mario Petrou, Keith M Channon, Charalambos Antoniades
Journal: Circulation (2014)

Introduction: Obesity has been paradoxically associated with a better outcome of CAD patients, while anthropometic measures of obesity provide limited information on adipose tissue (AT) biology. We hypothesised that quantification of femoral AT (FemAT) deposition using U/S can provide mechanistic insights into the obesity paradox. Methods: FemAT biopsies from 185 pts undergoing coronary bypass surgery (CABG) were cultured ex vivo for secretome and gene expression studies. FemAT thickness was measured by U/S at both the anterior and exterior surface of the thigh, at the mid point of the distance between the iliac crest and the knee, and the average of both thighs was calculated. Malondialdehyde (MDA), a marker of oxidative stress, was measured in plasma and FemAT culture supernatants. Brachial artery (BA) flow mediated dilatation (FMD) and distensibility were assessed by U/S. Results: FemAT thickness was only weakly correlated with BMI (r=0.235, p&lt;0.001) and waist-to-hip ratio (WHR, r=-0.179, p&lt;0.05), suggesting that it provides different information to classic anthropometrics in obesity. Patients with increased FemAT thickness had lower plasma MDA (A), better FMD (B) and greater BA distensibility (C), despite of being more obese. On the contrary BMI did not predict systemic oxidative stress or vascular function, while WHR was weakly correlated only with FMD (rho=-0.156, p&lt;0.05). Increased FemAT thickness was associated with lower MDA release from FemAT culture supernatants (D), and lower IL6-receptor (E) / CD68 (F) expression in FemAT samples, suggesting lower endogenous oxidative stress, and less macrophages’ infiltration. Conclusions: Femoral fat accumulation is associated with lower local AT inflammation and favourable systemic effects on vascular function in CAD. Combining imaging with AT biology could help to better understand the role of obesity-related vascular disease and provide an explanation to the “obesity paradox”.
Vascular biomarkers derived from dynamic contrast-enhanced MRI predict response of vestibular schwannoma to antiangiogenic therapy in type 2 neurofibromatosis
Authors: Ka-Loh Li, Ibrahim Djoukhadar, Xiaoping Zhu, Sha Zhao, Simon Lloyd, Martin McCabe, Catherine McBain, D. Gareth Evans, Alan Jackson
Journal: Neuro-Oncology (2015)

Antiangiogenic therapy of vestibular schwannoma (VS) in type 2 neurofibromatosis can produce tumor shrinkage with response rates of 40%–60%. This study examines the predictive value of parameter-derived MRI in this setting. Twelve patients with 20 VSs were recruited. Each had at least one rapidly growing tumor. Patients were treated with bevacizumab, 5 mg/kg every 2 weeks. Patients with stable or reduced VS volume were maintained at 2.5–5 mg every 4 weeks after 6 months. Those who failed treatment had their bevacizumab discontinued. Dynamic contrast-enhanced (DCE) MRI performed prior to treatment using a high temporal resolution technique, and data were analyzed to allow measurement of contrast transfer coefficient (Ktrans), vascular fraction (vp), extravascular-extracellular fraction (ve). Relaxation rate (R1N) was measured using a variable flip angle technique. Apparent diffusional coefficient (ADC) was calculated from diffusion-weighted imaging. The predictive power of microvascular parameters and ADC were examined using logistic regression modeling. Responding tumors were larger (P < .001), had lower R1N (P < .001), and higher Ktrans (P < .05) and ADC (P < .01). They showed increases in R1N (P < .01) and reduction of Ktrans (P < .01) and ADC (P < .01). Modeling to predict response demonstrated significant independent predictive power for R1N (Β = − 0.327, P < .001), and Ktrans (Β = 0.156, P < .05). Modeling to predict percentage change in tumor volume at 90 days identified baseline tumor volume (Β = 5.503, P < .05), R1N (Β = − 5.844, P < .05), and Ktrans (Β = 5.622, P < .05) as independent significant predictors. In patients with type 2 neurofibromatosis, biomarkers from DCE-MRI are predictive of VS volume response to inhibition of vascular endothelial growth factor inhibition.
Pancreatic neuroendocrine tumors: Nosography, management and treatment
Authors: Michele Orditura, Angelica Petrillo, Jole Ventriglia, Anna Diana, Maria Maddalena Laterza, Alessio Fabozzi, Beatrice Savastano, Elisena Franzese, Giovanni Conzo, Luigi Santini, Fortunato Ciardiello, Ferdinando De Vita
Journal: International Journal of Surgery (2015)
Mutation of Perinatal Myosin Heavy Chain
Authors: Matthew A Brown
Journal: New England Journal of Medicine (2004)

Veugelers et al. (July 29 issue)1 report on patients with the trismus–pseudocamptodactyly syndrome as having a “Carney complex variant.” Among more than 500 patients with the Carney complex in our database, there are none with the trismus–pseudocamptodactyly syndrome.2,3...
The Privatization of Health Care Reform: Legal and Regulatory Perspectives
Authors: R. Andersen
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The value of clinical characteristics for the diagnosis of melanoma in patients presenting at a pigmented lesion clinic
Authors: R.E.J. Roach, E.I. Plasmeijer, R. Doorn, W. Bergman, N.A. Kukutsch
Journal: British Journal of Dermatology (2015)

Journal Article The value of clinical characteristics for the diagnosis of melanoma in patients presenting at a pigmented lesion clinic Get access R.E.J. Roach, R.E.J. Roach Department of Dermatology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden the Netherlands Search for other works by this author on: Oxford Academic Google Scholar E.I. Plasmeijer, E.I. Plasmeijer Department of Dermatology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden the Netherlands Search for other works by this author on: Oxford Academic Google Scholar R. van Doorn, R. van Doorn Department of Dermatology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden the Netherlands Search for other works by this author on: Oxford Academic Google Scholar W. Bergman, W. Bergman Department of Dermatology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden the Netherlands Search for other works by this author on: Oxford Academic Google Scholar N.A. Kukutsch N.A. Kukutsch Department of Dermatology Leiden University Medical Center Albinusdreef 2 2333 ZA Leiden the Netherlands Correspondence: Nicole A. Kukutsch. E‐mail: n.a.kukutsch@lumc.nl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 174, Issue 6, 1 June 2016, Pages 1401–1403, https://doi.org/10.1111/bjd.14375 Published: 01 June 2016
Telomerase activity in pleural effusions: diagnostic significance.
Authors: C T Yang, M H Lee, R S Lan, J K Chen
Journal: Journal of Clinical Oncology (1998)

PURPOSE To determine the diagnostic value of pleural fluid telomerase activity in distinguishing a malignant from a nonmalignant pleurol effusion in a cohort of patients undergoing thoracentesis. PATIENTS AND METHODS Using a polymerase chain reaction (PCR)-based assay, telomerase activity was examined in the pleural fluid cells obtained from 144 consecutive, unselected patients. According to the final diagnosis achieved, these patients were classified into three groups: group I consisted of 70 malignant pleural effusions diagnosed by either fluid cytology or pleural biopsy, group II consisted of 52 nonmalignant pleural effusions, and another 22 samples were categorized to be suspicious malignant pleural effusions (group III) due to inconclusive results in effusion cytology and percutaneous pleural biopsy, but were strongly suspicious in clinical settings. RESULTS The presence of telomerase activity was observed in 64 of 70 samples in group I (91.4%), three of 52 samples in group II (5.8%), and 20 of 22 samples in group III. All three nonmalignant, telomerase-positive pleural effusion samples in group II were obtained from patients with tuberculosis. As a diagnostic criterion for malignant pleural effusion in group I and group II patients, positive telomerase activity had a sensitivity of 91.4%, a specificity of 94.2%, and a positive and negative predictive value of 0.96 and 0.89, respectively. CONCLUSION Our results indicate that the detection of telomerase activity may be a useful adjunct to cytopathologic methods in the diagnosis of malignant pleural effusions.
Comparisons of nuclear-encoded small-subunit ribosomal RNAs reveal the evolutionary position of the Glaucocystophyta.
Authors: D Bhattacharya, T Helmchen, C Bibeau, M Melkonian
Journal: Molecular Biology and Evolution (1995)

The Glaucocystophyta (e.g., Cyanophora paradoxa) form a morphologically distinct group of photosynthetic protists that is primarily distinguished by its cyanelles (= plastids). To elucidate their evolutionary relationships, we determined nuclear-encoded small-subunit ribosomal RNA (SSU rRNA) coding regions for four taxa classified in the Glaucocystophyta (C. paradoxa, Glaucocystis nostochinearum, Glaucosphaera vacuolata, Gloeochaete wittrockiana; sensu Kies and Kremer), and these sequences were positioned within the eukaryotic phylogeny. Maximum likelihood, maximum-parsimony, and neighbor-joining phylogenetic analyses show that the Glaucocystophyta is a relatively late-diverging monophyletic assemblage within the "crown" group radiation that forms a sister group to cryptophyte algae. Glaucosphaera vacuolata is a red alga and lacks some cyanelle (e.g., bounding peptidoglycan wall) and host cell (e.g., cruciate flagellar roots) characters typical of glaucocystophytes. Our data are consistent with a monophyletic origin of the cyanelle in the glaucocystophytes. The distribution of photosynthetic taxa within the glaucocystophytes/cryptophytes and other lineages such as the filose amoebae/chlorarachniophytes and heterokont protists provide clues to the origin of plastids with four bounding membranes. We speculate that multiple, likely independent, secondary endosymbioses gave rise to these plastids.
Capecitabine but not 5-FU worsened hepatosplenomegaly and liver function when used with oxaliplatin and cetuximab as first-line treatment in K-ras wild-type metastatic colorectal cancer.
Authors: Victor HF Lee, Weijia Fang, Ka On Lam, Cheuk Wai Choi, Sherry CY Ng, Patty PY Ho, Garrett CL Ho, Thomas KC Cheng, Rico KY Liu, To Wai Leung, Dora Lai Wan Kwong, Shusen Zheng
Journal: Journal of Clinical Oncology (2013)

e14530 Background: MRC COIN study showed that OXA and CAP (CAPOX) have greater toxicities compared with OXA and 5-FU (FOLFOX) when cetuximab (C225) was added for mCRC. Meanwhile, OXA was associated with splenomegaly and hepatic sinusoidal injury. We investigated if CAPOX+C225 worsened hepatosplenomegaly and liver function compared with FOLFOX+C225 in K-rasWT mCRC. Methods: 97 patients with K-ras WT mCRC received either FOLFOX or CAPOX (n=57) or the same regimen+C225 (n=40) as 1 st line treatment. CT scan of abdomen was performed at baseline and then after every 3-4 cycles. Liver excluding liver metastases if present, and spleen size at baseline and after treatment were contoured in Eclipse Treatment Planning System. Changes in liver and spleen size after treatment in all patients and subgroups (1) use of C225 and (2) CAPOX vs. FOLFOX +/- C225 were compared. Logistic regression was done for any predictors of hepatosplenomegaly and impaired liver function in all patients and subgroups. Results: 25, 32, 15 and 25 patients received FOLFOX, CAPOX, FOLFOX+C225 and CAPOX+C225 respectively.All patients had hepato- (p=0.014) and splenomegaly (p=0.000) after treatment. C225 did not further worsen hepato- (p=0.430) and splenomegaly (p=0.614). Cumulative dose of CAP was predictive of hepato- (p=0.003) and splenomegaly (p=0.008) even after adjusted for cumulative dose of OXA (p=0.021). For subgroup analysis, hepato- (p=0.040) and splenomegaly (p=0.041) were noted when CAPOX+C225 was compared with FOLFOX+C225, but not seen when CAPOX was compared with FOLFOX (p=0.270 and p=0.287 respectively). When comparing CAPOX+C225 with FOLFOX+C225, use of CAP was predictor of both hepato- (p=0.043) and splenomegaly (p=0.007). Dose intensity of CAP (p=0.036) and cumulative dose of OXA (p=0.044) are predictors of ≥grade 1 impaired liver function. However when comparing CAPOX with FOLFOX, no predictor was found for any complication. Conclusions: CAP further worsened hepatosplenomegaly and liver function when combined with OXA and C225 but not with OXA alone, suggesting that CAP and C225 together may add toxicity to liver and spleen.
Establishment and Characterization of a Human T-Cell Leukemia Line (LALW-2) in Nude Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: L White, P R Meyer, W F Benedict
Journal: JNCI Journal of the National Cancer Institute (1984)

Lymphoblasts from the peripheral blood of a 10-year-old boy who was treated for T-cell acute lymphoblastic leukemia were heterotransplanted intraocularly into nude mice. The resultant tumors and their metastases were serially passaged both intraocularly and subcutaneously in the mice. The mouse tumors closely resembled morphologically and cytochemically a human T-cell lymphoma. The primary cells, as well as cells from subsequent in vivo passages, were predominantly of a suppressor T-cell phenotype (OKT8-positive). No viral products were identified. Chromosome analysis revealed a near-diploid karyotype with a translocation between chromosomes 11 and 14. The tumorigenicity, morphology, cytochemistry, immunologic phenotype, and karyotypic pattern of the cells remained constant through six serial in vivo passages over a period of 10 months. This is the first report of direct heterotransplantation and long-term in vivo maintenance of primary human T-cells in immunologically unmanipulated nude mice.
Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12
Authors: Bart Everts, Roxane Tussiwand, Leentje Dreesen, Keke C. Fairfax, Stanley Ching-Cheng Huang, Amber M. Smith, Christina M. O’Neill, Wing Y. Lam, Brian T. Edelson, Joseph F. Urban, Kenneth M. Murphy, Edward J. Pearce
Journal: The Journal of Experimental Medicine (2015)

CD8α+ and CD103+ dendritic cells (DCs) play a central role in the development of type 1 immune responses. However, their role in type 2 immunity remains unclear. We examined this issue using Batf3−/− mice, in which both of these DC subsets are missing. We found that Th2 cell responses, and related events such as eosinophilia, alternative macrophage activation, and immunoglobulin class switching to IgG1, were enhanced in Batf3−/− mice responding to helminth parasites. This had beneficial or detrimental consequences depending on the context. For example, Batf3 deficiency converted a normally chronic intestinal infection with Heligmosomoides polygyrus into an infection that was rapidly controlled. However, liver fibrosis, an IL-13–mediated pathological consequence of wound healing in chronic schistosomiasis, was exacerbated in Batf3−/− mice infected with Schistosoma mansoni. Mechanistically, steady-state production of IL-12 by migratory CD103+ DCs, independent of signals from commensals or TLR-initiated events, was necessary and sufficient to exert the suppressive effects on Th2 response development. These findings identify a previously unrecognized role for migratory CD103+ DCs in antagonizing type 2 immune responses.
Use of clinical predictors on diagnosis of OSAS in patients with chronic obstructive pulmonary disease, asthma and cardiovascular diseases
Authors: Hamdy Ali Mohammadien Mahmoud, Suzan S. Salama, Aza A. Mohammad
Journal: European Respiratory Journal (2014)

Objective: The aim of this study was to identify predictors for the diagnosis of OSASin patients with COPD, asthma and CVD.  Methods: This studyincluded 180 patients, 60 COPD, 60 asthmatics and 60 patients with CVD without previously diagnosed OSA. We evaluated a questionnaire on the clinical predictors of the obstructive sleep apnea syndrome (OSAS) and anthropometric, arterial blood gases &pul.F parameters.  Results: The multivariable logistic regression revealedthat Snoring & nocturia are a predictors for high ESS more than 10 in cardiac patients, uncontrolled DM and hypertension only in asthmatic patients and uncontrolled hypertension among all patients. D.M, Uncontrolled DM, Nocturia, poor memory & hypertension in COPD, Headache & hypertension, uncontrolled hypertension in all patients, & nocturia, Uncontrolled DM, poor memory in asthmatic are a strong predictors for high risk Berlines and STOP Bang questionnaire. Nocturia is strong predictor for high risk ASA Checklist in all patients, headache in cardiac patients,while poor memory, hypertension and D.M. in COPD.  BMI, neck & waist circumference cannot be used as a possible predictors in cardiac patients, while in asthmatics waist circumference can be used.  PaO2 and SaO2% at 12 am can predict day time sleepiness in all patients. PaCO2, PaO2 and SaO2% at 12 am were a predictors of high risk of OSAS using STOP Bang, Berlines and ASA Checklist.  FEV1 was a significant predictor of high OSAS risk using high ESS & ASA Checklist in COPD not in asthmatics.   Conclusions:  We found that many predictors along with the used questionnaires can be utilized to predict the probability of having OSAS.
Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB
Authors: Nunziata Maio, Daniele Ghezzi, Daniela Verrigni, Teresa Rizza, Enrico Bertini, Diego Martinelli, Massimo Zeviani, Anamika Singh, Rosalba Carrozzo, Tracey A. Rouault
Journal: Cell Metabolism (2015)
Mediastinal lymph nodes (MLN) vascular pattern utilitiy to predict progression in lung cancer
Authors: Álvaro Donate Salcedo, Ana Virginia Quintero Salvago, María Fontillón, Lourdes Gómez Izquierdo, Beatriz Romero Romero, José Martín Juan
Journal: European Respiratory Journal (2014)

INTRODUCTION: The ultrasound pattern found in MLN during endobronchial ultrasound (EBUS) could distinguish between metastatic or not metastatic lymph nodes. As it has been previously demonstrated, a high blood flow image (Doppler color) is associated with angiogenesis, a higher risk of metastatic disease and a worse prognosis in others malignancies.

AIMS: to evaluate if the increased vascularization in MLN during EBUS could predict lung neoplasia progression, no response to chemotherapy and survival rate in non-small cell lung cancer (NSCLC) and other metastatic cancer (MC).

METHODS: A retrospective image analisis of 56 patients undergone to EBUS for diagnosis/staging: 45 NSCLC, 6 small cell lung cancer and 5 MC. Doppler vascularization grades (DVG) are those described by Nakajima T et al (J Thoracic Oncol 2012; 7: 1009-1014). Patients were classified into 3 groups according to DVG: 0, 1 and 2-3. Disease progression were defined as a increase T, N and/or M in CT. 28, 20 and 8 patients were included in each group, respectively. A survival study was performed using Kaplan-Meier curve.

RESULTS: The global mortality was 59%. Patients with metastatic MLN at the diagnosis were divided into the different groups according to vascularization grades: 33%, (group 0), 47% (group 1) and 62% (group 2-3). Disease progression did not show significative differences between groups: 67%, 78% and 75%, respectively. Mean survival rates were 27, 23 and 16 months, with no significative diffences neither.

CONCLUSION: Doppler color image pattern of MLN during EBUS may be useful to predict prognosis disease. However, prospective studies are necessary to confirm if these findings have clinical utility.
Arsenic-interferon-α–triggered apoptosis in HTLV-I transformed cells is associated with Tax down-regulation and reversal of NF-κB activation
Authors: Marwan E. El-Sabban, Rihab Nasr, Ghassan Dbaibo, Olivier Hermine, Nour Abboushi, Frédérique Quignon, Jean Claude Ameisen, Françoise Bex, Ali Bazarbachi
Journal: Blood (2000)