DANGER OF AIRPLANE FLIGHT TO PERSONS WITH SICKLEMIA
Authors: B. H. Sullivan
Journal: Annals of Internal Medicine (1950)

Case Reports1 February 1950DANGER OF AIRPLANE FLIGHT TO PERSONS WITH SICKLEMIAB. H. SULLIVAN JR.B. H. SULLIVAN JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-2-338 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe sickle cell trait (sicklemia) is estimated to occur in 7.4 per cent of Negroes. Only one in 15 cases of sicklemia shows anemia.1, 6This disorder of the erythrocytes is inherited as a Mendelian dominant and is confined to persons of the Negro race, with few possible exceptions. In vitro sickling has been shown to depend upon the dissociation of oxyhemoglobin in the red blood cell4; when the hemoglobin is in the reduced state the cells sickle, when the hemoglobin is combined with oxygen the cells resume their normal discoid shape. The oxygen tension at which sickling occurs varies...Bibliography1. Lewis JH: The biology of the Negro, 1942, Univ. Chicago Press, Chicago, p. 235. Google Scholar2. MurphyShapiro RCS: Sickle cell disease, Arch. Int. Med. 74: 28, 1944. CrossrefGoogle Scholar3. MurphyShapiro RCS: Pathology of sickle cell disease, Ann. Int. Med. 23: 376, 1945. LinkGoogle Scholar4. HahnGillespie EVEB: Sickle cell anemia. Experimental study of sickle cell formation, Arch. Int. Med. 39: 233, 1927. CrossrefGoogle Scholar5. Sherman IJ: Sickle cell phenomenon with special reference to the differentiation of sickle cell anemia from sickle cell trait, Bull. Johns Hopkins Hosp. 67: 309, 1940. Google Scholar6. HendersonThornell ABHE: Observations on the effect of lowered oxygen tension on sicklemia and sickle cell anemia among military flying personnel, J. Lab. and Clin. Med. 31: 769, 1946. MedlineGoogle Scholar7. Wintrobe MM: Clinical hematology, 1946, Lea and Febiger, Philadelphia, p. 501. Google Scholar8. ReinhardMooreDubachWade EHCVRLJ: Effect of high O2 concentration on erythrogenesis, J. Clin. Invest. 23: 682, 1944. CrossrefMedlineGoogle Scholar9. WinsorBurch TGE: The EKG and cardiac state in active sickle cell anemia, Am. Heart J. 29: 685, 1945. CrossrefGoogle Scholar10. Klinefelter HF: The heart in sickle cell anemia, Am. J. Med. Sc. 203: 34, 1942. CrossrefGoogle Scholar11. FindlayBoulterMacGibbon GMEACB: A note on sickling and flying, J. Roy. Army Med. Corps 89: 138, 1947. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC Fort Dix, New Jersey*Received for publication December 13, 1947.From The Medical Service, Walter Reed General Hospital, Washington 25, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnemia at Altitude: Thalassemia, Sickle Cell Disease, and Other Inherited AnemiasSupplemental oxygen therapy recommendations in patients with sickle cell disease during air travel: A cross-sectional survey of North American health care providersSickle Cell Trait and AviationThe morbidity of sickle cell traitSplenic sequestration syndrome at mountain altitudes in sickle/hemoglobin C diseaseNeurological Manifestations in Sickle-Cell Disease With a Review of the Literature and Emphasis on the Prevalence of HemiplegiaBARRY A. PORTNOY, M.D., JOHN C. HERION, M.D.Primary cardiomyopathy in nonanemic patientsSickle cell states and cardiomyopathySICKLÆMIC HUMAN HYGROMETERSSickle Cell Trait and Superior Longitudinal Sinus ThrombosisERIC A. SCHENK, M.D.Abdominal crises associated with sicklemia and airplane flightsStudies in sickle cell anemiaPulmonary Infarction and Atrophy of the Spleen Associated with Sickle-Cell Hemoglobin C DiseaseIncidence and significance of abnormal hemoglobinsSPLENIC INFARCTION IN SICKLEMIA DURING AIRPLANE FLIGHT: PATHOGENESIS, HEMOGLOBIN ANALYSIS AND CLINICAL FEATURES OF SIX CASES*†ROYAL ROTTER, WILLIAM F. LUTTGENS, WESLEY L. PETERSON, ALBERT E. STOCK, ARNO G. MOTULSKY, M.D.Splenomegaly in sickle cell anemiaThe Human Hemoglobins in Health and DiseaseSickle-Cell Trait and Splenic Infarction Associated with High-Altitude FlyingTHE THERAPEUTIC RESPONSE OF TUBERCULOUS NEGROES WITH THE SICKLE CELL TRAIT*WILLIAM WEISS, M.D.Sickle-cell Disease 1 February 1950Volume 32, Issue 2Page: 338-342KeywordsBlood cellsHemoglobinMedical servicesOxygenOxyhemoglobinRacial and ethnic issues Issue Published: 1 February 1950 PDF downloadLoading ...