tbuckley/cabot-search huggingface dataset:
Temperature as an Assistance to Diagnosis in Some Cases of Encephalitis
Authors: E. C. Fox
Journal: BMJ (1874)

ckement returned, and she would then pass the day in repeating the same expressions.This state continued for about a month, during which time she frequently refused to take food, declaring that she was unable to swallow; so that she was reduced to a state of great emaciation.Then she became quiet and comparatively calm, but still very uneasy and distressed in mind.For the first time, she complained of pain, all over her body.Her tongue was parched and dark brown; her pulse rapid and extremely feeble.After remaining for about a week in this condition, she gradually and quietly sank.Post A0ortent Examination Forty Hours after Death.-April15th, Weather not warm.Along each side of the falx cerebri, the membranes were closely adherent to each other, and firmly attached to the side of the falx and to the skull a little beyond it.The entire brain was verysmall and particularly globular in shape.The veins on its surface were full of dark-coloured blood, and several large clots were found in the longitudinal sinus.Beneath the arachnoid, a quantity of fluid was found in the sulci between the convolutions, which in some places were extremely atrophied.At the vertex, over a somewhat circular area of about an inch and a half in diameter, on each side of the longitudinal fissure, the convolutions were so atrophied, that the spaces between them were in some instances three quarters of an inch in breadth.It was over this space that the membranes were adherent to each other, as well as to the falx and skull.The quantity of fluid which ran out from beneath the arachnoid was about two ounces and a half.The substance of the hemispheres was not at all soft.When sliced, the grey portion pre- sented its normal colour and consistence, and was not unusually vascular.The lateral ventricle contained a small quantity of fluid.The right optic thalamus was decidedly smaller than the left, and somewhat soft.The corpus striatum on the left side was decidedly small, soft, and altered in shape, being bent, as it were, upon itself.The pons and medulla oblongata were very small.
Stress response regulators identified through genome-wide transcriptome analysis of the (p)ppGpp-dependent response in Rhizobium etli
Authors: Maarten Vercruysse, Maarten Fauvart, Ann Jans, Serge Beullens, Kristien Braeken, Lore Cloots, Kristof Engelen, Kathleen Marchal, Jan Michiels
Journal: Genome biology (2011)

The alarmone (p)ppGpp mediates a global reprogramming of gene expression upon nutrient limitation and other stresses to cope with these unfavorable conditions. Synthesis of (p)ppGpp is, in most bacteria, controlled by RelA/SpoT (Rsh) proteins. The role of (p)ppGpp has been characterized primarily in Escherichia coli and several Gram-positive bacteria. Here, we report the first in-depth analysis of the (p)ppGpp-regulon in an α-proteobacterium using a high-resolution tiling array to better understand the pleiotropic stress phenotype of a relA/rsh mutant. We compared gene expression of the Rhizobium etli wild type and rsh (previously rel) mutant during exponential and stationary phase, identifying numerous (p)ppGpp targets, including small non-coding RNAs. The majority of the 834 (p)ppGpp-dependent genes were detected during stationary phase. Unexpectedly, 223 genes were expressed (p)ppGpp-dependently during early exponential phase, indicating the hitherto unrecognized importance of (p)ppGpp during active growth. Furthermore, we identified two (p)ppGpp-dependent key regulators for survival during heat and oxidative stress and one regulator putatively involved in metabolic adaptation, namely extracytoplasmic function sigma factor EcfG2/PF00052, transcription factor CH00371, and serine protein kinase PrkA. The regulatory role of (p)ppGpp in R. etli stress adaptation is far-reaching in redirecting gene expression during all growth phases. Genome-wide transcriptome analysis of a strain deficient in a global regulator, and exhibiting a pleiotropic phenotype, enables the identification of more specific regulators that control genes associated with a subset of stress phenotypes. This work is an important step toward a full understanding of the regulatory network underlying stress responses in α-proteobacteria.
Prognostic models for diffuse large B-cell lymphoma in the rituximab era: a never-ending story
Authors: A. Bari, L. Marcheselli, S. Sacchi, R. Marcheselli, S. Pozzi, P. Ferri, E. Balleari, P. Musto, S. Neri, M.A. Aloe Spiriti, M.C. Cox
Journal: Annals of Oncology (2009)
Dr. Rentoul's Election Expenses, and those Incurred in Opposing the Four Midwives Bills
Authors: C. Campbell, F. J. A. Waring, J. A. Myrtle, D. Fraser, C. H. Sers, W. Lattey, J. W. O'Bryen, J. E. Garner, W. E. Barton, W. A. Wetwan, J. R. Williams, J. B. Close, J. M. Ferguson, A. Cox
Journal: BMJ (1897)
Severe lung inflammation is a feature of IPF
Authors: Emanuela Rossi, Elisabetta Balestro, Fiorella Calabrese, Graziella Turato, Erica Bazzan, Francesca Lunardi, Marco Schiavon, Marco Damin, Simonetta Baraldo, Federico Rea, Marina Saetta, Manuel Cosio
Journal: European Respiratory Journal (2013)

Background.  Lung inflammation is neither considered an important feature of IPF nor an important factor in its pathogenesis. However the degree and type of lung inflammation has never been carefully quantified and characterized in the different phenotypes of IPF.  Aim.  To quantify and define the type of inflammation in slow decliners (S), rapid decliners (R) and acute exacerbation (AE) phenotypes of IPF and relate it to the functional decline.  Methods.  59 patients IPF, referred for lung transplant, were followed for 37 (12-156) months. A 10% FVC decline/year cut-off was used to define the R (>10%) and S ( Results.  Total leukocytes were markedly increased in R (median; range: 653;428-973 cells/mm 2 ) and AE (682;513-921 cells/mm 2 ) when compared with S (213;91-252 cells/mm 2 ) (p Conclusions.  A severe innate and adaptive inflammation differentiates the S from the R and AE phenotypes of IPF. The apparent correlation between inflammation and decline suggests a possible role for inflammation on the mechanism of rapid progression in IPF. Different phenotypes should be taken in consideration in the design of treatment trials.
A risk score to predict disease-free survival in patients not achieving a pathological complete remission after preoperative chemotherapy for breast cancer
Authors: M. Colleoni, V. Bagnardi, N. Rotmensz, S. Dellapasqua, G. Viale, G. Pruneri, P. Veronesi, R. Torrisi, A. Luini, M. Intra, V. Galimberti, E. Montagna, A. Goldhirsch
Journal: Annals of Oncology (2009)
Costs and consequences: Hepatitis C seroprevalence in the military and its impact on potential screening strategies
Authors: David M. Brett‐Major, Kevin D. Frick, Jennifer A. Malia, Shilpa Hakre, Jason F. Okulicz, Charmagne G. Beckett, Linda L. Jagodinski, Michael A. Forgione, Philip L. Gould, Stephen A. Harrison, Clinton K. Murray, Francisco J. Rentas, Adam W. Armstrong, Aatif M. Hayat, Laura A. Pacha, Peter Dawson, Angelia A. Eick‐Cost, Hala H. Maktabi, Nelson L. Michael, Steven B. Cersovsky, Sheila A. Peel, Paul T. Scott
Journal: Hepatology (2015)

Knowledge of the contemporary epidemiology of hepatitis C viral (HCV) infection among military personnel can inform potential Department of Defense screening policy. HCV infection status at the time of accession and following deployment was determined by evaluating reposed serum from 10,000 service members recently deployed to combat operations in Iraq and Afghanistan in the period 2007-2010. A cost model was developed from the perspective of the Department of Defense for a military applicant screening program. Return on investment was based on comparison between screening program costs and potential treatment costs avoided. The prevalence of HCV antibody-positive and chronic HCV infection at accession among younger recently deployed military personnel born after 1965 was 0.98/1000 (95% confidence interval 0.45-1.85) and 0.43/1000 (95% confidence interval 0.12-1.11), respectively. Among these, service-related incidence was low; 64% of infections were present at the time of accession. With no screening, the cost to the Department of Defense of treating the estimated 93 cases of chronic HCV cases from a single year's accession cohort was $9.3 million. Screening with the HCV antibody test followed by the nucleic acid test for confirmation yielded a net annual savings and a $3.1 million dollar advantage over not screening.Applicant screening will reduce chronic HCV infection in the force, result in a small system costs savings, and decrease the threat of transfusion-transmitted HCV infection in the battlefield blood supply and may lead to earlier diagnosis and linkage to care; initiation of an applicant screening program will require ongoing evaluation that considers changes in the treatment cost and practice landscape, screening options, and the epidemiology of HCV in the applicant/accession and overall force populations.
Quantitative Multiplex Methylation-Specific PCR Assay for the Detection of Promoter Hypermethylation in Multiple Genes in Breast Cancer
Authors: Mary Jo Fackler, Megan McVeigh, Jyoti Mehrotra, Marissa A. Blum, Julie Lange, Amanda Lapides, Elizabeth Garrett, Pedram Argani, Saraswati Sukumar
Journal: Cancer Research (2004)

Abstract If detected early, breast cancer is eminently curable. To detect breast cancer in samples with little cellularity, a high level of sensitivity is needed. Tumor-specific promoter hypermethylation has provided such a valuable tool for detection of cancer cells in biological samples. To accurately assess promoter hypermethylation for many genes simultaneously in small samples, we developed a novel method, quantitative multiplex-methylation-specific PCR (QM-MSP). QM-MSP is highly sensitive (1 in 104–105 copies of DNA) and linear over 5 orders of magnitude. For RASSF1A, TWIST, Cyclin D2, and HIN1, we observed significant differences in both the degree (P &amp;lt; 0.003) and incidence (P &amp;lt; 0.02) of hypermethylation between normal and malignant breast tissues. Evaluation of the cumulative hypermethylation of the four genes within each sample revealed a high level of sensitivity (84%) and specificity (89%) of detection of methylation. We demonstrate the application of this technique for detecting hypermethylated RASSF1A, TWIST, Cyclin D2, HIN1, and RARB in 50–1000 epithelial cells collected from breast ducts during endoscopy or by lavage. Such an approach could be used in a variety of small samples derived from different tissues, with these or different biomarkers to enhance detection of malignancy.
Patient and Tumor Characteristics and BRAF and KRAS Mutations in Colon Cancer, NCCTG/Alliance N0147
Authors: Wilson I. Gonsalves, Michelle R. Mahoney, Daniel J. Sargent, Garth D. Nelson, Steven R. Alberts, Frank A. Sinicrope, Richard M. Goldberg, Paul J. Limburg, Stephen N. Thibodeau, Axel Grothey, Joleen M. Hubbard, Emily Chan, Suresh Nair, Jeffrey L. Berenberg, Robert R. McWilliams
Journal: JNCI Journal of the National Cancer Institute (2014)

BackgroundKRAS and BRAFV600E mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them.
Role of the Milk Agent in Disappearance of Mammary Cancer in C3H/StWi Mice23
Authors: Gilbert H. Smith
Journal: JNCI Journal of the National Cancer Institute (1966)

Journal Article Role of the Milk Agent in Disappearance of Mammary Cancer in C3H/StWi Mice Get access Gilbert H. Smith Gilbert H. Smith Department of Biology, Brown University, Providence, Rhode Island 4Present address: Laboratory of Viral Carcinogenesis, National Cancer Institute, Bethesda, Md. 20014. 5I gratefully acknowledge the helpful suggestions and constructive criticism of Professors Elizabeth H. Leduc and J. Walter Wilson throughout this investigation. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 36, Issue 4, April 1966, Pages 685–701, https://doi.org/10.1093/jnci/36.4.685 Published: 01 April 1966 Article history Received: 02 August 1965 Published: 01 April 1966
DO TOURNAMENT SCHEDULE AND SQUAD COMPOSITION INFLUENCE INJURY TYPES AND RATES IN INTERNATIONAL RUGBY?
Authors: P Mathema, I Moore, C Ranson
Journal: British Journal of Sports Medicine (2014)

Background This report contrasts injury rates, types and potential risk factors between two equal length yet markedly different international rugby campaigns. Objective To compare tournament injury problems and potential risk factors for single nation versus combined nation international rugby teams. Design Details of all time-loss injuries, training and match exposure for the Wales Team during the 2013; 6 Nations, and British and Irish Lions (BIL) during the Australia tour. Analysis was based on consensus injury surveillance methods. Setting International Rugby Union. Participants All Wales (n=36) and 2013 BIL squad (n=45) players. Risk factor assessment Contrasting injury exposure, rates and severity. MainoOutcome measurement Training and match injury; exposure, incidence, (per 1000hours), prevalence (% of players unavailable) and days-lost per injury. Results Wales played 5 matches and BIL 10 in a similar time period. 81% of Wales' squad players played in at least one match as compared to 98% of BIL. Wales had 28% more training hours exposure. Wales had a higher injury incidence/1000 hrs than BIL (total 27 vs. 18, match 260 vs. 90, training 5 vs. 4) and prevalence (15 vs. 10%), but fewer days-lost per injury (11 vs. 17). For Wales, 67% of the squad sustained injuries, with an average of 1.6 injuries per injured player whilst 54% of BIL sustained injuries (1.1 per injured player). Forty-seven percent of Wales players started in a match and half were replaced in at least one game as compared to 62% of BIL players and 92% being replaced. Of the match injuries, 81% of Wales' players, versus 56% BIL, completed the match. Conclusions Higher injury rates for Wales may have been due to factors such as; lower substitution rates, greater starter match exposure and previously injured players returning to play in the same tournament.
Comparison of Ion-Channel Subunit Expression in Canine Cardiac Purkinje Fibers and Ventricular Muscle
Authors: Wei Han, Weisheng Bao, Zhiguo Wang, Stanley Nattel
Journal: Circulation Research (2002)

Although Purkinje fibers (PFs) play an important role in cardiac electrophysiology, almost nothing is known about the expression of ion-channel subunits in PFs. We applied competitive reverse transcription-polymerase chain reaction, Western blotting, and immunocytochemistry to compare the expression of ion-channel subunit mRNA and protein in canine PFs versus ventricular muscle (VM). For transient outward current-related subunits, Kv4.2 was not detected, and Kv1.4 expression was extremely low. Kv4.3 expression was of the same order for VM and PFs. The tetraethylammonium chloride-sensitive subunit Kv3.4 was expressed much more strongly in PFs than in VM, and Kv channel-interacting protein transcript expression was 25-fold stronger in VM than in PFs. For delayed rectifiers, ERG and KvLQT1 expression was lower in PFs at both mRNA and protein levels. Although minK transcripts were more numerous in PFs, minK protein was significantly more strongly expressed in VM. L-type Ca2+ current alpha-subunit (Ca(V)1.2) and Na+-Ca2+ exchanger proteins were more strongly expressed in VM than in PFs. For T-type Ca2+ current, Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3 transcripts were all more strongly expressed in PFs. For the nonselective cation current, hyperpolarization-activated cation channel 1 (HCN1) expression was subquantifiable, HCN2 transcript expression was comparable in PFs and VM, and HCN4 mRNA expression was strong in PFs but below the detection threshold in VM. HCN2 and HCN4 protein expression was much stronger in PFs than in VM. We conclude that ion-channel subunit expression in PFs differs from that in VM in ways that are consistent with, and shed light on the molecular basis of, well-recognized fundamental PF ionic properties.
Clinical Impact of OCT Findings During PCI
Authors: Francesco Prati, Enrico Romagnoli, Francesco Burzotta, Ugo Limbruno, Laura Gatto, Alessio La Manna, Francesco Versaci, Valeria Marco, Luca Di Vito, Fabrizio Imola, Giulia Paoletti, Carlo Trani, Corrado Tamburino, Luigi Tavazzi, Gary S. Mintz
Journal: JACC. Cardiovascular imaging (2015)
Activation of Aminoflavone (NSC 686288) by a Sulfotransferase Is Required for the Antiproliferative Effect of the Drug and for Induction of Histone γ-H2AX
Authors: Ling-hua Meng, Uma Shankavaram, Chi Chen, Keli Agama, Hai-qing Fu, Frank J. Gonzalez, John Weinstein, Yves Pommier
Journal: Cancer Research (2006)

Abstract Aminoflavone (AF) is entering clinical trials. We recently reported that AF induces DNA-protein cross-links (DPC) and γ-H2AX in MCF-7 human breast cancer cells. To elucidate the mechanism of action of AF and provide biomarkers indicative of AF activity, we correlated AF activity profile (GI50) with gene expression patterns in the NCI-60 cell lines. Sulfotransferases (SULT) showed the highest positive correlation coefficients among ∼14,000 probe sets analyzed (r = 0.537, P &amp;lt; 0.001). Stable transfection of SULT1A1 into AF-resistant MDA-MB-231 cells sensitized these cells to AF. AF produced DPCs, γ-H2AX foci, and S-phase arrest in the SULT1A1-transfected but not in the parent MDA-MB-231 cells. Conversely, cells in which SULT1A1 was knocked down by small interfering RNA failed to induce γ-H2AX. Inhibition of SULTs and cytochrome P450 (CYP) enzymes by natural flavonoids blocked the antiproliferative activity of AF and the formation of AF-DNA adducts. AF also induces SULT1A1 and CYP expression in MCF-7 cells, suggesting the existence of an aryl hydrocarbon receptor–mediated positive feedback for AF activation by CYP and SULT1A1. Metabolism studies showed that AF can be oxidized by CYP at two amino groups to form N-hydroxyl metabolites that are substrates for bioactivation by SULTs. We propose that both N-sulfoxy-groups can be further converted to nitrenium ions that form adducts with DNA and proteins. The results reported here show the importance of SULT1A1 and CYP for AF activation and anticancer activity. They also suggest using SULT1A1 and γ-H2AX as biomarkers for prediction of AF activity during patient selection and monitoring of clinical trials. (Cancer Res 2006; 66(19): 9656-64)
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
Authors: Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, Toyonori Kato, Ayaka Atsumi, Takashi Yamamoto, Noriyuki Inoue, Mayumi Ishikawa, Sumiyo Okada, Naomi Ishigaki, Hitoshi Iwasaki, Yuko Iwasaki, Tadayoshi Karasawa, Shin Kumadaki, Toshiyuki Matsui, Motohiro Sekiya, Ken Ohashi, Alyssa H Hasty, Yoshimi Nakagawa, Akimitsu Takahashi, Hiroaki Suzuki, Sigeru Yatoh, Hirohito Sone, Hideo Toyoshima, Jun-ichi Osuga, Nobuhiro Yamada
Journal: Nature Medicine (2007)
Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation
Authors: Daijiro Sugiyama, Makoto Tanaka, Kenji Kitajima, Jie Zheng, Hilo Yen, Tomotaka Murotani, Atsushi Yamatodani, Toru Nakano
Journal: Blood (2007)
On to the road to degradation: atherosclerosis and the proteasome
Authors: J. Herrmann, L. O. Lerman, A. Lerman
Journal: Cardiovascular Research (2009)

Protein metabolism is a central element of every living cell. The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism machinery mediating post-transcriptional processing and degradation of the majority of intracellular proteins. Over the past few years, remarkable progress has been made in our understanding of the role of the UPS in vascular biology and pathobiology, particularly atherosclerosis. This review reflects on the recent developments from the effects on endothelial cells and the initial stage of atherosclerosis to the effects on vascular smooth muscle and the progression stage of atherosclerosis and finally to the effects on cell viability and the complication stage of atherosclerosis. It will conclude with the integration of the available information in a synoptic view of the involvement of the UPS in atherosclerosis.
Interplay between Mycoplasma Surface Proteins, Airway Cells, and the Protean Manifestations of Mycoplasma-mediated Human Infections
Authors: J. B. Baseman, S. P. Reddy, S. F. Dallo
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Adherence of mycoplasmas to specific tissue surfaces is a crucial step in the establishment of infection. Several pathogenic mycoplasmas are flask-shaped and possess specialized tips that permit a highly oriented surface parasitism of host target cells. Mycoplasma pneumoniae, which causes primary atypical pneumonia in humans, requires a network of interactive adhesins and accessory proteins to cytadhere. The adhesins must cluster at the mycoplasma tip organelle in close association with cytadherencerelated accessory proteins and a naplike structure, which together appear to comprise a primitive cytoskeletonlike system. Proline-rich regions associated with these proteins play critical roles in the maintenance of the structural and functional integrity of the tip. Mycoplasma genitalium, originally isolated from the human urogenital tract of patients with nongonococcal urethritis, also colonizes airway cells along with M. pneumoniae. The molecular basis for cytadherence of these mycoplasmas is discussed in terms of the identification, cloning, and sequencing of the implicated mycoplasma genes, their common DNA and amino acid homologies and structural and functional domains, and the organizational similarities in their cytadherence-related operons. In addition, the multiorgan protean manifestations of mycoplasma infection are discussed in terms of the role that mycoplasma adhesins may play in molecular mimicry, postinfectious autoimmunity, and immune-mediated damage.
"Metosyn" in Psoriasis and Eczema
Authors: B. Portnoy, I. Sarkany
Journal: British Journal of Dermatology (1972)

Journal Article "Metosyn" in Psoriasis and Eczema Get access B. Portnoy, B. Portnoy Manchester and Salford Hospital for Skin Diseases, Royal Free Hospital, London Search for other works by this author on: Oxford Academic Google Scholar I. Sarkany I. Sarkany Manchester and Salford Hospital for Skin Diseases, Royal Free Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 3, 1 March 1972, Pages 310–311, https://doi.org/10.1111/j.1365-2133.1972.tb02236.x Published: 01 March 1972
Severe tracheobronchial stenosis in a patient with Crohn′s disease
Authors: T. Kuźniar, C. Sleiman, O Brugière, O Groussard, H Mal, F Mellot, R Pariente, J Malolepszy, M Fournier
Journal: European Respiratory Journal (2000)

Tracheobronchial involvement in Crohn9s disease is rare, usually associated with symptoms of tracheobronchitis, and typically responds well to steroids. The authors report a case of a 29-yr old patient with Crohn9s disease, who presented with dyspnoea, fever, and a productive cough. Computed tomography of the chest revealed extensive nodular tracheobronchial stenosis, that was accompanied by severe mucosal inflammation at bronchoscopy. High-dose oral steroids diminished the mucosal inflammation, but had limited efficacy on the underlying tracheobronchial stenosis. It is speculated that this relative ineffectiveness of steroids may be due to the persistence of the untreated inflammatory process.