tbuckley/cabot-search huggingface dataset:
Systemic Transfer of Tumor Immunity: Delayed Hypersensitivity and Suppression of Tumor Growth
Authors: Harold T. Wepsic, Berton Zbar, Herbert J. Rapp, Tibor Borsos
Journal: JNCI Journal of the National Cancer Institute (1970)

Delayed hypersensitivity and tumor-specific growth suppression were passively transferred to unimmunized recipient strain-2 guinea pigs. Transfer was accomplished by the injection of peritoneal exudate cells into the heart of unimmunized strain-2 animals. The recipients were challenged by the intradermal inoculation of living tumor cells; tumorspecific delayed hypersensitivity and growth suppression were obtained. Cell fractions containing lymphocytes and neutrophils were the most active in the passive transfer of tumor-specific delayed hypersensitivity and tumor growth suppression.
Frontiers of cardiovascular imaging: Edited by B L Zaret, L Kaufman, A S Berson, R A Dunn. (Pp 362; $103.50.) New York: Raven Press, 1993. ISBN 0-7817-0077-9
Authors: G. Angelini
Journal: Cardiovascular Research (1995)

Frontiers of cardiovascular imaging: Edited by B L Zaret, L Kaufman, A S Berson, R A Dunn. (Pp 362; $103.50.) New York: Raven Press, 1993. ISBN 0-7817-0077-9 Get access Frontiers of Cardiovascular Imaging. Edited by Zaret B L Kaufman L Berson A S Dunn R A: (Pp 362; $103.50.) (New York: Raven Press, 1993). ISBN 0-7817-0077-9. GD Angelini GD Angelini Bristol, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 6, June 1995, Page 879, https://doi.org/10.1016/S0008-6363(95)90121-3 Published: 01 June 1995
Israel stops private medical services in state hospitals.
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2002)

Private medical services launched without official approval six years ago in hospitals owned by the Israeli government will have to shut down by 30 April.

The services, known by their Hebrew acronym “sharap,” have been provided in five of Israel's largest state hospitals. The cancellation of the services is the result of a 49 page ruling by attorney general Elyakim Rubinstein and months of deliberations about the controversial subject.

Sharap began informally, without official authorisation, in the mid-1990s in state hospitals in the metropolitan area of Tel Aviv and in Haifa. Patients who wanted to see specific doctors were told to deposit money in fictitious “research funds,” and the proceeds were then divided between the more experienced physicians. These payments sometimes also shortened the wait to see a doctor or have an operation.

The attorney general's ruling leaves the door open for a new form of private medical practice that would allow paying patients to choose their consultants or surgeons, but not to see them faster than patients who do not pay.
Enzyme Discovery May Lead to New Treatments for Metabolic Disorders
Authors: Tracy Hampton
Journal: JAMA (2016)

Researchers have discovered a metabolic pathway that plays a key role in glucose, lipid, and energy balance in mammalian cells, presenting a new potential approach for treating metabolic disorders (Mugabo Y et al. Proc Natl Acad Sci U S A. 2016;113[4]:E430-E439).
Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination
Authors: Danyang He, Corentine Marie, Chuntao Zhao, Bongwoo Kim, Jincheng Wang, Yaqi Deng, Adrien Clavairoly, Magali Frah, Haibo Wang, Xuelian He, Hatem Hmidan, Blaise V Jones, David Witte, Bernard Zalc, Xin Zhou, Daniel I Choo, Donna M Martin, Carlos Parras, Q Richard Lu
Journal: Nature Neuroscience (2016)
Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial
Authors: Takuma Higurashi, Kunihiro Hosono, Hirokazu Takahashi, Yasuhiko Komiya, Shotaro Umezawa, Eiji Sakai, Takashi Uchiyama, Leo Taniguchi, Yasuo Hata, Shiori Uchiyama, Akiko Hattori, Hajime Nagase, Takaomi Kessoku, Jun Arimoto, Nobuyuki Matsuhashi, Yoshiaki Inayama, Shoji Yamanaka, Masataka Taguri, Atsushi Nakajima
Journal: The Lancet Oncology (2016)
The spectrum of autosomal dominant polycystic kidney disease in children.
Authors: G M Fick, I T Duley, A M Johnson, J D Strain, M L Manco-Johnson, P A Gabow
Journal: Journal of the American Society of Nephrology (1994)

The natural history of autosomal dominant polycystic kidney disease (ADPKD) has not been well described in children, and it is not known whether a relationship exists between renal structural abnormalities and function in children as has been seen in adults. Therefore, 140 children from 67 ADPKD families were studied in a prospective study. Only 22 children came with a previous diagnosis of ADPKD. In 44% of all children, at least one cyst was found on ultrasound at a mean age of 8.7 yr. Of these, 60% were classified as having moderate disease on the basis of a total cyst number of 1 to 10 cysts, whereas 40% were considered to have severe disease with a total of more than 10 cysts. There was a significant relationship between the severity of the renal structural involvement and the frequency of flank and back pain, hypertension, and impaired renal concentrating capacity. However, GFR were not reduced in children with ADPKD and did not relate to structural severity. Thirty-nine children were seen for a follow-up visit 2 to 5 yr after the initial visit. No child had progressed from nonaffected to affected with ADPKD, but three of four children with only one cyst at the time of the initial study had progressed to bilateral cysts. Among the 22 ADPKD children who had a follow-up study, there was progression of the disease, reflected by an increase in cyst number and an increase in the frequency of pain and hypertension. However, GFR remained stable in all children.(ABSTRACT TRUNCATED AT 250 WORDS)
It is time to give concussion an operational definition: a 3-step process to diagnose (or rule out) concussion within 48 h of injury: World Rugby guideline
Authors: Martin Raftery, Simon Kemp, Jon Patricios, Michael Makdissi, Philippe Decq
Journal: British Journal of Sports Medicine (2016)

ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. It's time to give concussion an operational definition: A 3-step process to diagnose (or rule out) concussion within 48 hours of injury: World Rugby Guideline
Neurological services need urgent attention, say MPs
Authors: Adrian O’Dowd
Journal: BMJ (2016)

People with neurological conditions in England are being neglected and there are too many examples of poor care across the country, MPs on the parliamentary public accounts committee have said.

The committee published a report on 26 February about the progress that had been made since its predecessor committee reported on the issue in 2012.1 The committee made recommendations to improve care for people with conditions such as Parkinson’s disease, motor neurone disease, and epilepsy.

There are around 4.7 million people with neurological conditions in England, and MPs on the current committee said that while …
Positive Interaction between Prophylactic Cranial Irradiation and Maintenance Sunitinib for Untreated Extensive-Stage Small Cell Lung Cancer Patients After Standard Chemotherapy: A Secondary Analysis of CALGB 30504 (ALLIANCE)
Authors: Joseph K. Salama, Lin Gu, Xiaofei Wang, Herbert H. Pang, Jeffrey A. Bogart, Jeffrey Crawford, Steven E. Schild, Everett E. Vokes, Neal E. Ready
Journal: Journal of Thoracic Oncology (2015)
Coping styles of 34 adolescents with cerebral palsy
Authors: K K Minde
Journal: American Journal of Psychiatry (1978)

The author presents a follow-up study of 34 children with cerebral palsy. Eight years previously 23 of these children were attending a special school for handicapped children, and 11 were attending regular schools. The author evaluated the children and their families through formal and informal interviews and by administering parent and teacher rating scales of the children's behavior. He found that the development of these children between the ages of 10 and 14 was highlighted by their increased awareness and their parents' awareness of the permanence of their handicap and their consequent search for personal and, ultimately, occupational identity and their parents' emotional withdrawal.
Continuous Cell Culture From a Patient With Chronic Myelogenous Leukemia. II. Detection of a Herpes-Like Virus by Electron Microscopy
Authors: Victor H. Zeve, Linda S. Lucas, Robert A. Manaker
Journal: JNCI Journal of the National Cancer Institute (1966)

Ultrastructural characteristics of one cell type contained in the M-2 line derived from the buffy coat of a patient with chronic myelogenous leukemia are described. Herpes-like particles found in approximately 5% of this cell type are compared with particles described from Burkitt lymphoma lines and the RPMI 64–10 line derived from a patient with acute myelogenous leukemia. The significance of nuclear and mitochondrial changes accompanying viral infection is discussed. Virus associated with the M-2 line is morphologically indistinguishable from that of several Burkitt lymphoma and RPMI 64–10 lines.
P0045 : Long term low dose steroid triple immunosuppressive regimens in post transplant autoimmune hepatitis (AIH) patients reduces the incidence of recurrent disease and is not associated with increased mortality
Authors: T.L. Krishnamoorthy, J. Miezynska-Kurtycz, J. Hodson, B.K. Gunson, J. Neuberger, P. Milkiewicz, Y.H. Oo
Journal: Journal of Hepatology (2015)
Lung cancer cure, care, and cost: let the data be your guide.
Authors: M G Kris
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.9.3027 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9294464 Lung cancer cure, care, and cost: let the data be your guide. M G KrisxM G KrisSearch for articles by this author https://doi.org/10.1200/JCO.1997.15.9.3027 First Page PDF © 1997 by American Society of Clinical Oncology
Hyperplastic and Neoplastic Changes in the Mammary Glands of Feral Mice Free of Endogenous Mouse Mammary Tumor Virus Provirus&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: L J Faulkin, D J Mitchell, L J Young, D W Morris, R W Malone, R D Cardiff, M B Gardner
Journal: JNCI Journal of the National Cancer Institute (1984)

Laboratory colonies of feral mice (Mus musculus domesticus) have been established with specific mouse mammary tumor virus (MuMTV) genotype, including colonies lacking any proviral DNA (ev-) or carrying only a single copy of MuMTV DNA (ev+). No evidence of a decline in reproductive capacity has been observed in the first 8 generations. Both the ev- and ev+ mice showed normal mammary gland development and the development of hyperplastic lesions in the older females. The mice were very resistant to spontaneous or chemically induced mammary tumors. However, the occurrence of 1 mammary tumor in an ev- mouse indicates that mammary neoplasias can occur in the absence of MuMTV DNA. The few tumors that do occur in the ev- mice provide a unique opportunity to study the neoplastic process in the absence of proviral DNA.
Effect of Insulin on Glucose Production and Utilization in Diabetes
Authors: N KALANT, T R CSORBA, N HELLER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anti-therapeutic community mental health law
Authors: K C Calman
Journal: BMJ (1995)

<h3>Background</h3> Serious bacterial infections in young infants with bronchiolitis are rare. Febrile infants &lt;1 month old with bronchiolitis often receive a lumbar puncture (LP), despite limited data for this practice and lack of clinical practice guidelines for this population. The primary objective was to investigate practice patterns in performance of LPs in the ED management of febrile infants aged ≤30 days with bronchiolitis. <h3>Methods</h3> A cross-sectional survey of two national paediatric emergency research networks (PediatricEmergency Research Canada (PERC) and the PediatricEmergency Research UK/Ireland (PERUKI)) was conducted January to November 2017 using a modified Dillman technique. The survey was preceded by a clinical vignette describing a well appearing, 21-day-old infant with low-grade fever, respiratory findings typical of bronchiolitis and no perinatal serious bacterial infection (SBI) risk features. <h3>Results</h3> The response rate from PERC was 169/250 (68%) and 172/201 (86%) from PERUKI. Nine physicians in training were excluded, leaving 332 eligible participants. Although most physicians believe that neonates with bronchiolitis rarely have meningitis (PERC 141/161 (87.6%); PERUKI 154/171 (90%)) and feel comfortable diagnosing bronchiolitis in this group (PERC 136/161 (84.5%); PERUKI 143/171 (83.6%)), there was significant variation in the proportion who would be likely/very likely to perform an LP (PERC 100/161 (62.1%); PERUKI 15/171 (8.8%)) (p&lt;0.0001). Practice in Canada, &lt;10 years in practice and lack of comfort with diagnosing bronchiolitis represent multivariable predictors of LP; OR 23.7 (95% CI 11.7 to 47.9), 2.3 (95% CI 1.2 to 4.2) and 2.5 (95% CI 1.1 to 5.0), respectively. Rapid knowledge of respiratory syncytial virus positivity would decrease LP probability from 35.4% to 20.2%. <h3>Conclusion</h3> Estimated probability of performing LPs and other interventions in otherwise healthy febrile neonates with bronchiolitis is highly variable between emergency physicians in Canada and the UK/Ireland. Network, &lt;10 years in ED practice and comfort level with diagnosing bronchiolitis in newborns constitute independent predictors of the likelihood of LP performance.
A novel approach to manage skin toxicity caused by therapeutic agents targeting epidermal growth factor receptor.
Authors: Rossana Berardi, Anna Campanati, Azzurra Onofri, Chiara Pierantoni, Irene Conte, Katia Giuliodori, E Molinelli, Fabiana Marcucci, Annamaria Offidani, Stefano Cascinu
Journal: Journal of Clinical Oncology (2012)

636 Background: Inhibition of EGFR represents an important field in cancer therapy.Skin rash is a common adverse reaction in patients receiving EGFR inhibitors. Nicotinamide has been shown to be an effective treatment for skin inflammation in various conditions, since nicotinamide inhibits IL-8 production through the NF-kB and MAPK pathways in an in vitro keratinocytes/P. acnes model of inflammation. Furthermore green tea polyphenols could be useful in attenuation of solar UVB light-induced oxidative stress-mediated and MAPK-caused skin disorders in humans.In this study we evaluated the effect of nicotinamide and green tea polyphenols on skin toxicity EGFRI related. Methods: Patients with skin toxicity induced by EGFRI were enrolled. They underwent a skin biopsy and skin samples for microbiological analyses at first presentation of skin toxicity (T0). Skin toxicity was assessed with NCI-CTACE,EGFR index and Dermatology Life Quality Index (DLQI) test. Therapy protocol consisted in topical application of moisturizing cream containing green tea polyphenols plus oral administration of nicotinamide 200 mg/die for 12 weeks. Topical application of 1% clindamycin gel and/or systemic administration of minocicline were provided in case of superbacterial infection. All treated patients were monitored for at least 12 weeks (T12), across three time points (T0,T6,T12). Results: 24 colorectal cancer patients receiving anti-EGFR monoclonal antibodies (cetuximab or panitumumab) and developing skin toxicity were treated by a multidisciplinary team including oncologists, dermatologists, a pathologist and a nurse. All the patients experienced a significant reduction of skin toxicity according to the NCI-CTACE and EGFR index (p&lt;0.05). Papulo-pustular eruption and itching significantly improved after 6 weeks of treatment and erythema decreased after 12 weeks. A significative improvement of the global score and of DLQI was evident. No toxicity related to the treatment of skin toxicity was observed. Conclusions: Treatment with nicotinamide and green tea polyphenols represent a novel effective approach to manage skin toxicity caused by EGFRI.
Design of a phase 3, international multicenter, prospective, randomized, double-blind, placebo controlled study assessing the efficacy and safety of lanreotide depot 120 mg in patients with well-differentiated, advanced typical and atypical lung neuroendocrine tumors (NETs)
Authors: Diane Reidy-Lagunes, Edward M. Wolin, Susan Pitman Lowenthal, David Cox, Matthew H. Kulke
Journal: Journal of Thoracic Oncology (2016)
Cyclooxygenase-2 Induction by Arsenite through the IKKβ/NFκB Pathway Exerts an Antiapoptotic Effect in Mouse Epidermal Cl41 cells
Authors: Weiming Ouyang, Dongyun Zhang, Qian Ma, Jingxia Li, Chuanshu Huang
Journal: Environmental Health Perspectives (2006)

BackgroundArsenic contamination has become a major public health concern worldwide. Epidemiologic data show that long-term arsenic exposure results in the risk of skin cancer. However, the mechanisms underlying carcinogenic effects of arsenite on skin remain to be studied.ObjectivesIn the present study we evaluated cyclooxygenase-2 (COX-2) expression, the signaling pathways leading to COX-2 induction, and its antiapoptotic function in the response to arsenite exposure in mouse epidermal JB6 Cl41 cells.MethodsWe used the luciferase reporter assay and Western blots to determine COX-2 induction by arsenite. We utilized dominant negative mutant, genetic knockout, gene knockdown, and gene overexpression approaches to elucidate the signaling pathway involved in COX-2 induction and its protective effect on cell apoptosis.ResultsThe induction of COX-2 by arsenite was inhibited in Cl41 cells transfected with IKKβ-KM, a dominant mutant inhibitor of kβ (Ikβ) kinase (IKKβ), and in IKKβ-knockout (IKKβ−/−) mouse embryonic fibroblasts (MEFs). IKKβ/nuclear factor κB (NFκB) pathway-mediated COX-2 induction exerted an antiapoptotic effect on the cells exposed to arsenite because cell apoptosis was significantly enhanced in the Cl41 cells transfected with IKKβ-KM or COX-2 small interference RNA (siCOX-2). In addition, IKKβ−/− MEFs stably transfected with COX-2 showed more resistance to arsenite-induced apoptosis compared with the same control vector–transfected cells.ConclusionsThese results demonstrate that arsenite exposure can induce COX-2 expression through the IKKβ/NFκB pathway, which thereby exerts an antiapoptotic effect in response to arsenite. In light of the importance of apoptosis evasion during carcinogenesis, we anticipate that COX-2 induction may be at least partially responsible for the carcinogenic effect of arsenite on skin.
NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma
Authors: Robin Kit-Ho Lai, Iris Ming-Jing Xu, David Kung-Chun Chiu, Aki Pui-Wah Tse, Larry Lai Wei, Cheuk-Ting Law, Derek Lee, Chun-Ming Wong, Maria Pik Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Journal: Clinical Cancer Research (2016)

Hepatocellular carcinoma (HCC) lacks effective curative therapy. Hypoxia is commonly found in HCC. Hypoxia elicits a series of protumorigenic responses through hypoxia-inducible factor-1 (HIF1). Better understanding of the metabolic adaptations of HCC cells during hypoxia is essential to the design of new therapeutic regimen.Expressions of genes involved in the electron transport chain (ETC) in HCC cell lines (20% and 1% O2) and human HCC samples were analyzed by transcriptome sequencing. Expression of NDUFA4L2, a less active subunit in complex I of the ETC, in 100 pairs of HCC and nontumorous liver tissues were analyzed by qRT-PCR. Student t test and Kaplan-Meier analyses were used for clinicopathologic correlation and survival studies. Orthotopic HCC implantation model was used to evaluate the efficiency of HIF inhibitor.NDUFA4L2 was drastically overexpressed in human HCC and induced by hypoxia. NDUFA4L2 overexpression was closely associated with tumor microsatellite formation, absence of tumor encapsulation, and poor overall survival in HCC patients. We confirmed that NDUFA4L2 was HIF1-regulated in HCC cells. Inactivation of HIF1/NDUFA4L2 increased mitochondrial activity and oxygen consumption, resulting in ROS accumulation and apoptosis. Knockdown of NDUFA4L2 markedly suppressed HCC growth and metastasis in vivo HIF inhibitor, digoxin, significantly suppressed growth of tumors that expressed high level of NDUFA4L2.Our study has provided the first clinical relevance of NDUFA4L2 in human cancer and suggested that HCC patients with NDUFA4L2 overexpression may be suitable candidates for HIF inhibitor treatment. Clin Cancer Res; 22(12); 3105-17. ©2016 AACR.