tbuckley/cabot-search huggingface dataset:
INTERACTION BETWEEN ALCOHOL HABIT AND GENE POLYMORPHISM OF BETA-2 ADRENERGIC RECEPTOR ON THE RISK OF HIGH-NORMAL BLOOD PRESSURE
Authors: Masahiko Eto, Masanobu Okayama, Taro Takeshima, Maki Kumada, Takanori Aonuma, Yoshikazu Nakamura, Eiji Kajii
Journal: Journal of the American College of Cardiology (2015)
Carpal-tunnel Syndrome
Authors: P. H. Kendall
Journal: BMJ (1962)

Carpal-tunnel Syndrome SIR,-In your annotation on "Carpal-tunnel 'Syndrome" (October 21, 1961, p. 1075) it is suggested ,that although the injection of hydrocortisone into the .carpaltunnel is usually followed by rapid relief of symptoms it is a painful procedure.In fact the Aiscomfort experienced by the patient during injection
Abstract 2158: RAF signaling and SHOC2 mediate mutant NRAS acquired resistance to RAF inhibitors in melanoma
Authors: Curtis H. Kugel
Journal: Cancer Research (2012)

Abstract RAS signaling through extracellular signal-regulated kinase 1/2 (ERK1/2)/mitogen-activated kinase (MAPK) pathway is critical for normal cellular homeostasis and is frequently aberrantly regulated in cancerous cells. Although often depicted as a linear sequence of RAS-RAF-MEK-ERK1/2, this pathway is also regulated by expression of multiple isoforms of proteins at each level, scaffold proteins that enhance pathway activation, and negative feedback mechanisms. Some of these factors may also impact on the response of the pathway to pharmacological inhibitors. To test this notion, we analyzed resistance to the RAF inhibitor, PLX4720, using mutant BRAF melanoma cell models. In a screen to isolate cells displaying resistance to the inhibitory effects of PLX4720, we observed a subset of cells harboring an acquired mutation in NRAS. In parental cells, expression of mutant NRAS was sufficient to prevent PLX4720-mediated inhibition of ERK1/2 signaling, entry into S phase and susceptibility to apoptosis in mutant BRAF cells. Effects of mutant NRAS were associated with the maintenance of RAF binding. Analysis of isolated clones of RAF inhibitor-resistant mutant BRAF cells demonstrated that re-activation of the ERK1/2 pathway in the presence of PLX4720 was dependent on NRAS, BRAF, CRAF, and the RAS-RAF scaffold protein, SHOC2/Sur-8. Depletion of SHOC2 also rendered resistant cells susceptible to PLX4720-mediated apoptosis in 3D collagen. Together, these data demonstrate the role of RAF isoforms and a RAS-RAF scaffold protein in the acquired resistance to RAF inhibitors induced by secondary mutations in NRAS. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2158. doi:1538-7445.AM2012-2158
Fat Embolism Syndrome
Authors: Hsiao-Kan Liu, Wen-Chau Chen
Journal: New England Journal of Medicine (2011)

A 48-year-old man who had a traumatic fracture of the left femoral shaft 20 hours earlier was referred for a deterioration of consciousness that began after the fracture occurred. He was unresponsive to verbal stimuli; no focal neurologic abnormalities were found.
Impaired Vision in Dim Light
Authors: Milan D. Chepko
Journal: JAMA (1986)

<h3>To the Editor.—</h3> In the Jan 24/31 issue ofThe Journal,<sup>1</sup>a physician requested information on impaired vision in dim light. In the reply, Dr Appen indicated that the cause might be a shift in the spectral sensitivity of the retina as it converts from cone vision, which predominates in bright light, to rod vision, which predominates in dim light, combined with the inherent chromatic aberration of the lens. Certainly these factors exist, but he may have overlooked spherical aberration, which should be a much more significant cause of decreased acuity in dim light. Even the poorest photographic lens will produce a relatively good image when it is stopped down to a very small iris opening, such as<i>f</i>1:16 or<i>f</i>1:22, because only a small region centered on the axis of the lens is actually delivering light rays to the film plane. However, as you open the
Adjuvant imatinib (IM) for patients (pts) with primary gastrointestinal stromal tumor (GIST) at significant risk of recurrence: PERSIST-5 planned 3-year interim analysis.
Authors: Chandrajit P. Raut, N. Joseph Espat, Robert G Maki, Dejka M. Araujo, Christopher Hunt Keir, Toni Faith Williams, Ronald P. DeMatteo
Journal: Journal of Clinical Oncology (2015)

10537 Background: Adjuvant IM treatment improves survival in pts with primary GIST with significant risk of recurrence. However, optimal treatment duration has not been determined. The ongoing PERSIST-5 trial is evaluating 5 years of adjuvant IM treatment. Methods: Beginning in 2009, this single-arm trial has included pts at significant risk of recurrence, defined as either primary tumor ≥ 2 cm at any site and ≥ 5 mitoses/50 high-power fields or nongastric primary GIST ≥ 5 cm. After complete resection of primary KIT+ GIST, pts received IM 400 mg/day for 5 y or until progression, relapse, or intolerance. The primary endpoint was recurrence-free survival (RFS). We report data from a planned 3-y interim analysis. Results: Of 91 eligible pts (median age 60 y; range, 30-90 y), median tumor size was 6.5 cm (range, 2.3-30.0 cm), 55% had gastric GIST, and 99% underwent R0 resection. In 85 evaluable pts, the most common GIST genotypes were KIT exon 11 (68%) and PDGFRA exon 18 (9%). Median time from resection to first IM dose was 9.6 wk (range, 3.1-12.3 wk).As of the data cutoff (May 9, 2014), median treatment duration was 34.2 mo (range, 0.5-55.8 mo). Overall, 4 pts (4%) recurred. There was 1 death; this pt had an IM-resistant PDGFRA D842V mutation. No pts without this resistant mutation who stayed on IM recurred. All 3 surviving pts who recurred discontinued (D/C) IM prior to recurrence (range, 7.3-23.1 mo between D/C and recurrence). The most common reasons for D/C (n = 33) were adverse events (AEs; n = 13) or consent withdrawal (n = 13). Grade 3/4 AEs leading to D/C were elevated liver enzymes, alveolitis, and renal cell carcinoma (n = 1 each). The most common AEs were nausea (67%), diarrhea (53%), and fatigue (44%). Dose reduction, occurring in 31 pts (34%), was most frequently due to AEs (n = 22), most commonly neutropenia, nausea, and hypophosphatemia (n = 3 each). Conclusions: Adjuvant IM was associated with high rates of survival and RFS.Most recurrences occurred after IM D/C. Data support 3 y of adjuvant IM for higher-risk pts. Additional follow-up will evaluate whether longer treatment improves outcomes. Clinical trial information: NCT00867113.
P314 CHARACTERISATION OF THE PLASMA METABOLIC PHENOTYPE OF ACUTE LIVER FAILURE BY H NMR SPECTROSCOPY
Authors: M.J. McPhail, D.L. Shawcross, R.D. Abeles, G. Manakkat Vijay, V. Patel, C.J. Karvellas, E. Leslie, W. Bernal, E. Holmes, J.A. Wendon, S.D. Taylor-Robinson
Journal: Journal of Hepatology (2014)
P349 INTRAHEPATIC REGULATORY T CELLS ARE ASSOCIATED WITH TREATMENT RESPONSE IN AUTOIMMUNE HEPATITIS TYPE 1 AND ARE DEPLETED WITH CURRENT THERAPIES
Authors: R. Taubert, M. Hardtke-Wolenski, F. Noyan, A. Wilms, A.K. Baumann, J. Schlue, S. Olek, M.P. Manns, E. Jaeckel
Journal: Journal of Hepatology (2014)
John Stuart Fraser
Authors: Andy Harrison
Journal: BMJ (2016)

John Stuart Fraser was born the son of a farmer near Forres in Inverness-shire. He was educated at Dyke Primary School and Forres Grammar. At the age 17 he was accepted to study medicine at Aberdeen University.

He graduated in 1953 and did his national service in the Royal Air Force. He was posted to RAF Newton, Nottinghamshire, where he did sessions helping the local GP in East Bridgford, Geoffrey Brookes. In 1957, after two years as a GP in …
ASSOCIATION BETWEEN PERIODIC LEG MOVEMENTS DURING SLEEP AND CLINICAL OUTCOMES IN HOSPITALIZED PATIENTS WITH SYSTOLIC HEART FAILURE FOLLOWING ACUTE DECOMPENSATION
Authors: Shoichiro Yatsu, Takatoshi Kasai, Shoko Suda, Azusa Murata, Takao Kato, Masaru Hiki, Tetsuro Miyazaki, Hiroyuki Daida
Journal: Journal of the American College of Cardiology (2015)
MY UNLIMITED POTENTIAL: ACHIEVING WEIGHT, FITNESS, AND CARDIOMETABOLIC HEALTH GOALS WITH MULTICOMPONENT LIFESTYLE INTERVENTION PROGRAM EXTENDING TO 1 YEAR IN HEALTH CARE EMPLOYEES
Authors: Henry Guzman, Maribeth Rouseff, Thinh Tran, Sankalp Das, Doris Brown, Joann Santiago-Charles, Teresa C. Ochoa, Joseph Mora, Cynthia Gilliam, Virginia Lehn, Beatriz Castillo, Ehimen Aneni, Emir Veledar, Oluseye Ogunmoroti, Janisse Post, Lara Roberson, Khurram Nasir
Journal: Journal of the American College of Cardiology (2015)
Abstract P4-01-16: Clinicopathological Factors that Predict the Accuracy of MRI in the Preoperative Setting.
Authors: Tomasz Czechura, Olga Kantor, Brigid Martz, David P Winchester, David J Winchester, Katharine Yao
Journal: Cancer Research (2012)

Abstract Withdrawn by Author Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-01-16.
Abstract 4990: Nuclear Factor-Y (NF-Y) regulates the transcription of the human aldo-keto reductase 1C1 (AKR1C1) gene*
Authors: Pallai Rajash, Henry Simpkins, Jianli Chen, Hemant K. Parekh
Journal: Cancer Research (2010)

Abstract Dihydrodiol dehydrogenases are a family of aldo-keto reductases (AKR1Cs) involved in the metabolism of steroid hormones and xenobiotics. Here, we have cloned and characterized the proximal promoter region of the human AKR1C1 gene. The 5′ flanking proximal promoter region of the AKR1C1 gene consists of a TATA box and an inverted CCAAT binding site. Deletion analysis of the 5′-flanking, ∼3.0 kb region of the human AKR1C1 gene, identified the region between −128 to −88 as the minimal proximal promoter that is essential for basal transcription of AKR1C1 in human ovarian (2008 &amp; 2008/C13*), lung (H23 &amp; A549) and liver carcinoma (HepG2) cells. Based on computational analysis, a set of potential putative transcription factor binding sites for Oct1, Sp1, NF-Y, C/EBP, p40X, USF, NF1 and AP-2 were identified in this region. Site-directed mutagenesis studies indicated that the transcription factor binding sites for NF-Y/CEBP were essential for controlling the basal transcription of AKR1C1 in all the cancer cells studied. Electrophoretic mobility shift (EMSAs) and gel supershift assays demonstrated that the transcription factor NF-Y preferentially binds to the inverted CCAAT box at −109ATTGG−105 of the AKR1C1 gene. These results indicate that the NF-Y transcription factor regulates the basal transcription of AKR1C1 in human ovarian, lung and liver carcinoma cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4990.
The Outcomes and Costs of Care for Acute Low Back Pain among Patients Seen by Primary Care Practitioners, Chiropractors, and Orthopedic Surgeons
Authors: Timothy S. Carey, Joanne Garrett, Anne Jackman, Curtis McLaughlin, John Fryer, Douglas R. Smucker
Journal: New England Journal of Medicine (1995)

Patients with back pain receive quite different care from different types of health care practitioners. We performed a prospective observational study to determine whether the outcomes of and charges for care differ among primary care practitioners, chiropractors, and orthopedic surgeons.
AB0009 Association of an HLA-G 3’UTR haplotype with susceptibility to rheumatoid arthritis: A north-south analysis in two independent brazilian cohorts: Table 1.
Authors: T.D. Veit, C. de Lima, C. Brenol, J.C. Brenol, A. Ribeiro, R. Correa, L. Cavalheiro, E. dos Santos, R. Xavier, J.A. Chies
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> HLA-G may exert long-term immunotolerogenic effects through the generation of suppressor cells [reviewed in [1]]. Such features render HLA-G an attractive candidate gene for susceptibility to immune mediated diseases. Indeed, our group has observed a positive association of a 3'UTR haplotype encompassing the 14bp locus and the +3142C/G (rs1063320) and disease susceptibility in patients with systemic lupus erythematosus [2]. <h3>Objectives</h3> To investigate the genetic influence of the two <i>HLA-G</i> 3'UTR polymorphisms – the 14 bp insertion/deletion (rs1704) and the +3142C&gt;G (rs1063320) – in the susceptibility to rheumatoid arthritis in a double-center study comprising a Southern-Brazilian cohort from Porto Alegre and Northern-Brazilian cohort from the city of Belém. <h3>Methods</h3> A total number of 546 RA patients and 531 controls was PCR genotyped for the two polymorphisms. <h3>Results</h3> Haplotype frequencies differed significantly between control groups from the Northern and Southern cohorts. After adjusting for city of origin and gender, we observed that female patients presented a higher frequency of the deletion-G (D/G) haplotype (OR=1.634, 95% CI=1.128–2.368, P=0.009). After stratifying for RF positivity, only the female RF+ group of patients presented statistical significance (OR=1.829, 95%C.I =1.243–2.690, P=0.002) - Table 1. <h3>Conclusions</h3> Our results suggest a differential influence of <i>HLA-G 3'UTR</i> polymorphisms in disease susceptibility, with the D/G haplotype as a risk factor for RA in RF+ females. <h3>References</h3> Carosella ED, HoWangYin K-Y, Favier B, LeMaoult J. Hla-g-dependent suppressor cells: Diverse by nature, function, and significance. Human immunology 2008;69:700-7. Consiglio CR, Veit TD, Monticielo OA, et al. Association of the hla-g gene +3142c&gt;g polymorphism with systemic lupus erythematosus. Tissue Antigens 2011;77:540-5. <h3>Disclosure of Interest</h3> None Declared
P1006 ARTIFICIAL NEURAL NETWORK: AN ACCURATE AND CHEAP METHOD FOR NONINVASIVE ASSESSMENT OF CHRONIC HEPATITIS B RELATED LIVER FIBROSIS
Authors: N.N. Salkic, P. Jovanovic, E. Alibegovic, M. Brcic, N. Krizic, S. Iljazovic-Topcic
Journal: Journal of Hepatology (2014)
We Blew It
Authors: Robert Kreisberg
Journal: New England Journal of Medicine (1995)

A 34-year-old homosexual man, who had been infected with the human immunodeficiency virus (HIV) since 1986 but without a defining illness of the acquired immunodeficiency syndrome (AIDS), presented with a two-week history of pruritus, jaundice, and loss of energy. He also had anorexia and intermittent nausea without vomiting, abdominal pain, or diarrhea. For several months he had had night sweats and intermittent fever with temperatures as high as 102°F. Four weeks earlier he had had an episode of sinusitis, which was treated first with erythromycin, but later with clarithromycin instead, because of gastrointestinal intolerance. He had been taking trimethoprim–sulfamethoxazole . . .
Incidence of Radiographically Evident Bone Disease, Nephrocalcinosis, and Nephrolithiasis in Various Types of Renal Tubular Acidosis
Authors: R.James Brenner, David B. Spring, Anthony Sebastian, Elisabeth M. McSherry, Harry K. Genant, Alphonse J. Palubinskas, R. Curtis Morris
Journal: New England Journal of Medicine (1982)

The syndrome of renal tubular acidosis has been categorized into three physiologic types that have different clinical findings and prognostic and therapeutic implications. We reviewed radiographs of the skeleton and kidneys in 92 patients (56 children and 36 adults) with renal tubular acidosis in order to determine whether the radiologic findings could be related to the type of syndrome. Forty-four patients had Type 1 renal tubular acidosis, 18 had Type 2, and 30 had Type 4. Evidence of skeletal abnormalities was uncommon (17 per cent) and was confined to patients who had the Type 2 disorder or azotemia. The children with Type 2 and skeletal abnormalities had rickets; the adults had osteopenia without pseudofractures. Nephrocalcinosis was evident in approximately one fourth of the group (29 per cent) and was restricted to patients with the Type 1 syndrome. In patients with Type 4, osteopenia was evident in 12 per cent, all of whom were azotemic. Our observations indicate that the radiographic manifestations of renal tubular acidosis are influenced by the physiologic type of renal tubular acidosis.
PTH-048 Perception Of Assessing The Nutritional Status Of Intensive Care Patients: A Cross Sectional Study Of Jordanian Icu Nurses
Authors: MT Al Kalaldeh
Journal: Gut (2014)

<h3>Introduction</h3> Enteral nutrition is a pivotal strategy for nutrition in ICUs (Fulbrook <i>et al</i>. 2007). Nurses are keys to assess patients’ nutritional status, detect feeding-intolerance, and curtail the prospect of complications (Persenius <i>et al</i>., 2006; Bourgault <i>et al</i>., 2007). This study aimed to assess ICU nurses’ perception of their ability to assess critically ill patients’ nutritional status using the evidence-based guidelines. <h3>Methods</h3> A cross sectional descriptive design was employed. A total of 190 ICU nurses from two health care sectors in Jordan participated in the study and completed a structured questionnaire prepared to assess nurses’ perception of patients’ nutritional status. <h3>Results</h3> Nurses showed greater levels of responsibility for ‘preventing complications’ and ‘evaluation’ than ‘assessment’ and ‘identifying goals’. Tube position is still confirmed via unreliable measures such as air bubbling technique (mean 4.00, SD 1.14). The mean for measuring Gastric Residual Volume was above the mid-point (3.70, SD 1.33). However, there was inconsistency in recognising the limit, threshold and frequency of measuring this volume. Diarrhoea is the most frequent complication of enteral nutrition (mean 3.36, SD 1.34) followed by abdominal pain, tube dislodgment, weight loss and uncontrolled blood sugar. Nurses perceived that the incidences of complications are less likely to occur in the presence of evidence-based guidelines than absence (rho= 0.73, df= 251, p &lt; 0.001). <h3>Conclusion</h3> Nurses show more concerns about the outcomes of enteral feeding instead of the preliminary assessment. Measuring GRV and confirming tube placement are still deficient and require further attention. EBP is acknowledged by nurses where undertaking such protocols is emphasised. <h3>References</h3> Adam S, Batson S. A study of problems associated with the delivery of enteral feed in critically ill patients in five ICUs in the UK.<i> Intensive Care Med</i> 1997;23:261–266 Bourgault A, Ipe, L, Weaver J, Odea, P. Development of evidence-based guidelines and critical care nurses’ knowledge of enteral feeding. <i>Critical Care Nurse</i> 2007;27:17–29 Fulbrook P, Bongers A, Albarran JW. A European survey of enteral nutrition practices and procedures in adult intensive care units.<i> Journal of Clinical Nursing</i> 2007;16:2132–2141 Mcclave SA, Martindale RG, Vanek VW, Mccarthy M, Roberts P, Taylor B, Ochoa JB, Napolitano L, Cresci G. GuidelinEs for the provision and assessment of nutrition support therapy in the adult critically Ill patient.<i> Journal of Parenteral and Enteral Nutrition</i> 2009;33:277–316 Persenius MW, Larsson BW, Hall-Lord M. Enteral nutrition in intensive care nurses’ perceptions and bedside observations.<i> Intensive and Critical Care Nursing</i> 2006;22:82–94 <h3>Disclosure of Interest</h3> None Declared.
Cigarette Advertising and Magazine Coverage of the Hazards of Smoking a Statistical Analysis
Authors: Kenneth E. Warner, Linda M. Goldenhar, Catherine G. McLaughlin
Journal: New England Journal of Medicine (1992)

Health professionals have charged that magazines that depend on revenues from cigarette advertising are less likely to publish articles on the dangers of smoking for fear of offending cigarette manufacturers. Special concern has focused on magazines directed to women. Restricted coverage of smoking hazards could lead readers to underestimate the risks of smoking in relation to other health risks.Using logistic-regression analysis of a sample of 99 U.S. magazines published during 25 years (1959 through 1969 and 1973 through 1986), we analyzed the probability that the magazines would publish articles on the risks of smoking in relation to whether they carried advertisements for cigarettes and in relation to the proportion of their advertising revenues derived from cigarette advertisements. We controlled for other factors that might influence coverage.The probability of publishing an article on the risks of smoking in a given year was 11.9 percent for magazines that did not carry cigarette advertisements, as compared with 8.3 percent for those that did publish such advertisements (adjusted odds ratio, 0.73; 95 percent confidence interval, 0.42 to 1.30). For women's magazines alone, the probabilities were 11.7 percent and 5.0 percent, respectively (adjusted odds ratio, 0.13; 95 percent confidence interval, 0.02 to 0.69). When the proportion of revenues derived from cigarette advertising was the independent variable, the probability of publishing an article on the risks of smoking in a given year was reduced by 38 percent (95 percent confidence interval, 18 percent to 55 percent) for magazines with the average proportion of total advertising revenues derived from cigarette advertising for the entire sample of magazines (6 percent) as compared with magazines with no cigarette advertising. This relation was particularly strong in the case of women's magazines. An increase of 1 percent in the share of advertising revenue derived from cigarette advertisements decreased the probability of covering the risks of smoking by three times as much as in other magazines.This study provides strong statistical evidence that cigarette advertising in magazines is associated with diminished coverage of the hazards of smoking. This is particularly true for magazines directed to women.
Epithelioid Hemangioendothelioma: a Rare Primary Thyroid Tumor with Confirmation of WWTR1 and CAMTA1 Rearrangements
Authors: Akeesha A. Shah, N. Paul Ohori, Linwah Yip, Christopher Coyne, Cristina R. Antonescu, Raja R. Seethala
Journal: Endocrine Pathology (2016)
Abstract 4863: Ubiquitination of the breast cancer oncogene IKKα is essential for transformation
Authors: Alicia Y. Zhou, Rhine R. Shen, Eejung Kim, Zhijian Chen, William C. Hahn
Journal: Cancer Research (2012)

Abstract IKBKE (IKKα) is a breast cancer oncogene that promotes human mammary cell transformation through the activation of the NF-κB pathway. Here we show that IKKα is modified by ubiquitination in the context of cell transformation. By mass spectrometry, we identified three lysine residues of IKKα that are ubiquitinated - Lysine30, Lysine401, and Lysine416. Mutation of all three lysine residues together eliminates IKKα ubiquitination. Single mutations of the three lysines revealed that K30 and K401 are essential for IKKα-induced malignant transformation. Although wildtype IKKα drives transformation in immortalized human cells, the IKKα K30R and IKKα K401R mutants fail to transform immortalized human cells. In addition, the IKKα K30R and IKKα K401R mutants fail to activate the NF-κB pathway and are unable to phosphorylate CYLD, a downstream target of IKKα. The ubiquitination of IKKα does not affect the protein stability of IKKα protein. Using an inducible ubiquitin-knockdown U2OS cell system, we show that IKKα specifically undergoes K63-linked polyubiquitination, a proteasome- and degradation-independent form of ubiquitination. Taken together, these data provide evidence that IKKα is subject to direct regulation by K63-linked polyubiquitination and that this ubiquitination is essential for IKKα-mediated oncogenic transformation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4863. doi:1538-7445.AM2012-4863
Recurrent Pulmonary Embolism Despite the Use of a Greenfield Filter
Authors: Jose R. Barreras, David M. Agarwal, Suresh T. Maximin, Adie Friedman
Journal: Clinical Nuclear Medicine (2001)

Barreras, Jose R. M.D.; Agarwal, David M. M.D.; Maximin, Suresh T. M.D.; Friedman, Adie M.D. Author Information