tbuckley/cabot-search huggingface dataset:
Opioid Prescribing After Surgical Extraction of Teeth in Medicaid Patients, 2000-2010
Authors: James A. Baker, Jerry Avorn, Raisa Levin, Brian T. Bateman
Journal: JAMA (2016)

Opioid abuse has reached epidemic proportions in the United States 1,2 and often begins with a prescription for a pain medication.Dentists are among the leading prescribers of opioid analgesics, 3 and surgical tooth extraction is one of the most frequently performed dental procedures.Surveys suggest that dental practitioners commonly prescribe opioids following this procedure, 4 despite evidence that a combination of nonsteroidal medications and acetaminophen may provide more effective analgesia for postextraction pain. 5Little information is available on nationwide patterns of opioid prescribing following tooth extraction.
miR-199-sponge transgenic mice develop physiological cardiac hypertrophy
Authors: Zhenhua Li, Lantao Liu, Ning Hou, Yao Song, Xiangbo An, Youyi Zhang, Xiao Yang, Jian Wang
Journal: Cardiovascular Research (2016)

Overexpression of either member of the miR-199 family, miR-199a-5p, or miR-199b-5p (hereinafter referred to as miR-199a or miR-199b) promotes pathological cardiac hypertrophy, but little is known about the role of endogenous miR-199 in cardiac development and disease. Our study aimed to determine the physiological function of the endogenous miR-199 family in cardiac homeostasis maintenance. We generated a sponge transgenic mouse model with a specific disruption of miR-199 in the heart. To our surprise, we found that knockdown of endogenous miR-199 caused physiological cardiac hypertrophy characterized by an increased heart weight and cardiomyocyte size, but with normal cardiac morphology and function. Furthermore, we also identified PGC1α as the target gene of the miR-199 family, and PGC1α was also increased in sponge transgenic mice. Inhibition of endogenous miR-199 led to physiological cardiac hypertrophy probably due to the up-regulation of PGC1α, uncovering a surprising role for endogenous miR-199 in the maintenance of cardiac homeostasis.
Myelodysplasia and Acute Leukemia After Autologous Bone Marrow Transplantation
Authors: James O. Armitage
Journal: Journal of Clinical Oncology (2000)

Article Tools EDITORIAL Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.5.945 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10694542 Myelodysplasia and Acute Leukemia After Autologous Bone Marrow Transplantation James O. Armitage, MDxJames O. ArmitageSearch for articles by this author Show More University of Nebraska Medical Center, Omaha, NE https://doi.org/10.1200/JCO.2000.18.5.945 Full Text PDF Figures and Tables "Myelodysplasia and Acute Leukemia After Autologous Bone Marrow Transplantation ." Journal of Clinical Oncology, 18(5), p. 945© 2000 by American Society of Clinical Oncology
Survivorship: Pain Version 1.2014
Authors: Crystal S. Denlinger, Jennifer A. Ligibel, Madhuri Are, K. Scott Baker, Wendy Demark-Wahnefried, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Grace H. Ku, Elizabeth Kvale, Terry S. Langbaum, Kristin Leonardi-Warren, Mary S. McCabe, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Javid J. Moslehi, Tracey O’Connor, Linda Overholser, Electra D. Paskett, Muhammad Raza, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole McMillian, Deborah Freedman-Cass
Journal: Journal of the National Comprehensive Cancer Network (2014)

Many posttreatment cancer survivors experience chronic pain, often leading to psychological distress; decreased activity, motivation, and personal interactions; and an overall poor quality of life. This section of the NCCN Guidelines for Survivorship provides screening and management recommendations for pain in survivors. A multidisciplinary approach is recommended, with a combination of pharmacologic treatments, psychosocial and behavioral interventions, physical therapy and exercise, and interventional procedures.
PTU-193 Wide variation in the use of radiotherapy in the management of surgically treated rectal cancer across the english NHS
Authors: EJA Morris, PJ Finan, PT Quirke, JD Thomas, K Spencer, S Lawton, R Adams, D Sebag-Montefiore
Journal: Gut (2015)

<h3>Introduction</h3> Radiotherapy is an important treatment modality in the multidisciplinary management of rectal cancer. It is delivered both in the neo-adjuvant setting and postoperatively but, whilst it reduces local recurrence, it does not influence overall survival and increases the risk of long-term complications. This has led to a variety of international practice patterns. This variation can have significant impact on commissioning but also future clinical research. This study explores its use within the large English National Health Service (NHS). <h3>Method</h3> Information on all individuals diagnosed with a surgically treated rectal cancer between the April 2009 and December 2010 were extracted from the Radiotherapy Dataset (RTDS) linked to the National Cancer Data Repository (NCDR). Individuals were grouped into those receiving no radiotherapy (NRT), short-course radiotherapy with immediate surgery (SCRT-I), short-course radiotherapy with delayed surgery (SCRT-D), long-course chemoradiotherapy (LCCRT), other radiotherapy (ORT) and post-operative radiotherapy (PORT). Patterns of use were then investigated. <h3>Results</h3> The study consisted of 9,201 individuals; 4,538 (49.3%) received some form of radiotherapy. SCRT-I was used in 12.3%, SCRT-D in 3.7%, LCCRT in 26.5%, ORT in 5.0% and PORT in 2.2%. Radiotherapy was used more commonly in men and in those receiving abdominoperineal excision and less commonly in the elderly and those with co-morbidity. Significant and substantial variations were also seen in its use across all the multidisciplinary teams managing this disease with the proportion of any radiotherapy use ranging from 5.1% to 77.8% of surgically treated rectal cancer patients treated in each of the MDTs managing the disease across England. <h3>Conclusion</h3> Wide variation exists in both the use of and type of radiotherapy delivered in the management of rectal cancer across the English NHS. Prospective population-based collection of local recurrence and patient-reported late toxicity information are required to further improve patient selection for preoperative radiotherapy. <h3>Disclosure of interest</h3> None Declared.
Are pneumonectomies (PN) after induction chemotherapy (CT) for non-small cell lung cancer (NSCLC) a reasonable procedure? A multicenter, retrospective study of 228 cases
Authors: Y. Thibout, B. Guibert, J. Gamondes, O. Tiffet, E. de la Roche, P. Souquet
Journal: Journal of Clinical Oncology (2008)

7530 Background: PN after induction CT for NSCLC is controversial due to excessive reported mortality. Methods: We conducted a multicenter, retrospective study including all patients treated by induction CT followed by PN for NSCLC, from January 1993 to April 2006, in 4 Academic General and Thoracic Surgery Departments. We studied postoperative mortality and morbidity and long-term outcomes. Results: 228 patients were included. Median age was 59 years and 85% were males. Histology was squamous cell carcinoma (58%), adenocarcinoma (29%) and others (11%). Doublets with cisplatin and vinorelbine or gemcitabine were used in 66% of cases. Stages pTNM (WHO 1997) were 0 (2%), I (16%), II (25%), IIIA (29%), IIIB (16%) and IV (12%). Postoperative morbidity rate was 37% (84/228). Independent risk factors identified for postoperative morbidity were: chronic obstructive pulmonary disease (COPD), induction CT with more than 4 cycles or by association of cisplatin with old cytotoxic molecule, extended PN and increased time of anesthesia. Postoperative mortality rates were 5.3% at 30 days (12/228) and 9.2% at 90 days (21/228). Causes of death at 90 days were acute respiratory failure without pneumonia (6/21), pneumonia (6/21), early metastatic recurrence (3/21), others (6/21). Independent risk factors identified for operative mortality were: COPD, manual suture of the stump and stage pTNM > IIIA. 90-days mortality rates were 10.3% (12/117) for right PN and 8.2% (9/111) for left PN (p=0.65). Overall survival rates were 68% at 1 year, 39% at 3 years and 32% at 5 year. 5-year survival were 66% for stages 0–1, 43% for stage II, 28% for stage IIIA, 11% for stage IIIB and 8% for stage IV. Conclusions: This large retrospective study suggests that induction CT does not compromise short and long-term outcomes after PN for NSCLC. Right or left PN after induction CT is a reasonable procedure, in experimented hands, if required by local extension. No significant financial relationships to disclose.
Impact of probiotic supplements on microbiome diversity following antibiotic treatment of mice
Authors: Hannah Grazul, L. Leann Kanda, David Gondek
Journal: Gut Microbes (2016)

Shifts in microbial populations of the intestinal tract have been associated with a multitude of nutritional, autoimmune, and infectious diseases. The limited diversity following antibiotic treatments creates a window for opportunistic pathogens, diarrhea, and inflammation as the microbiome repopulates. Depending on the antibiotics used, microbial diversity can take weeks to months to recover. To alleviate this loss of diversity in the intestinal microbiota, supplementation with probiotics has become increasingly popular. However, our understanding of the purported health benefits of these probiotic bacteria and their ability to shape the microbiome is significantly lacking. This study examined the impact of probiotics concurrent with antibiotic treatment or during the recovery phase following antibiotic treatment of mice. We found that probiotics did not appear to colonize the intestine themselves or shift the overall diversity of the intestinal microbiota. However, the probiotic supplementation did significantly change the types of bacteria which were present. In particular, during the recovery phase the probiotic caused a suppression of Enterobacteriaceae outgrowth (Shigella and Escherichia) while promoting a blooming of Firmicutes, particularly from the Anaerotruncus genus. These results indicate that probiotics have a significant capacity to remodel the microbiome of an individual recovering from antibiotic therapy.
Vascular diagnosis (4th edition) Edited by E F Bernstein. (Pp 1058; £180.) St Louis: Mosby-Year Book Inc, 1993. ISBN 0-8016-6557-4
Authors: T Suzuki
Journal: Cardiovascular Research (1995)

Vascular diagnosis (4th edition): Edited by E F Bernstein. (Pp 1058; £180.) St Louis: Mosby-Year Book Inc, 1993. ISBN 0-8016-6557-4 Get access T Suzuki, T Suzuki Tokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Y Yazaki Y Yazaki Tokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 4, April 1995, Pages 583–584, https://doi.org/10.1016/S0008-6363(95)90127-2 Published: 01 April 1995
Positron emission tomography in the clinical evaluation of metastatic cancer.
Authors: A J Fischman
Journal: Journal of Clinical Oncology (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.3.691 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8622012 Positron emission tomography in the clinical evaluation of metastatic cancer. A J FischmanxA J FischmanSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.3.691 First Page PDF © 1996 by American Society of Clinical Oncology
P1110 : Alcohol liver disease is more frequent and more severe than chronic viral hepatitis in Jails of a French District
Authors: C. Bonny, G. Lamblin, A. Lenat-Guyot, C. Henquell, C. Nicolas, S. Dydymski, B. Pereira, C. Jacomet, A. Abergel
Journal: Journal of Hepatology (2015)
Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects
Authors: R C Arora, H Y Meltzer
Journal: American Journal of Psychiatry (1989)

The authors determined serotonin2 (5-HT2) binding in the frontal cortex of 32 suicide victims and 37 subjects who died from nonpsychiatric causes. The maximum number of binding sites (Bmax) and the affinity (Kd) were significantly higher in subjects who had committed suicide than in control subjects. However, there was no difference in Kd between these two groups after the influence of age, race, sex, and postmortem delay was covaried. The Bmax of subjects who had committed violent suicide was significantly greater than that of control subjects.
A retrospective cohort study of pancreatic neuroendocrine tumors at single institution over 15 years: New proposal for low- and high-grade groups, validation of a nomogram for prognosis, and novel follow-up strategy for liver metastases
Authors: Liangtao Ye, Huilin Ye, Quanbo Zhou, Zhihua Li, Qing Lin, Langping Tan, Wenchao Gao, Zhiqiang Fu, Shangyou Zheng, Rufu Chen
Journal: International Journal of Surgery (2016)
Suppression of lethal‐7b and miR‐125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts
Authors: Yasuo Takashima, Maiko Terada, Miyako Udono, Shizuka Miura, Junpei Yamamoto, Atsushi Suzuki
Journal: Hepatology (2016)

In liver development, hepatoblasts that act as hepatic stem/progenitor cells proliferate and differentiate into both hepatocytes and cholangiocytes to form liver tissues. Although numerous factors contribute to this event, little is known about the roles of microRNAs in hepatoblast proliferation and differentiation. In this study, we focused on the lineage‐28 (Lin28) family proteins, which are required for microRNA regulation in pluripotent stem cells and cancer cells, and investigated their roles as regulatory factors for the properties of hepatoblasts. Conclusion : Lin28b was specifically expressed in hepatoblasts, and its suppression induced growth arrest and cholangiocyte differentiation of hepatoblasts; mechanistically, Lin28b positively regulates the expression of Lin28b itself and cell cycle–related proteins in hepatoblasts by suppressing the maturation of target microRNAs, lethal‐7b and miR‐125a/b, enabling maintenance of the stem cell properties of hepatoblasts, such as their capabilities for proliferation and bi‐lineage differentiation, during liver development. (H epatology 2016;64:245–260)
Isolation of a Virus From Cattle With Persistent Lymphocytosis
Authors: M. J. Van Der Maaten, Arlis D. Boothe, Cameron L. Seger
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Isolation of a Virus From Cattle With Persistent Lymphocytosis Get access M. J. Van Der Maaten, M. J. Van Der Maaten Search for other works by this author on: Oxford Academic PubMed Google Scholar Arlis D. Boothe, Arlis D. Boothe Search for other works by this author on: Oxford Academic PubMed Google Scholar Cameron L. Seger Cameron L. Seger Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 49, Issue 6, December 1972, Pages 1649–1657, https://doi.org/10.1093/jnci/49.6.1649 Published: 01 December 1972 Article history Received: 31 March 1972 Revision received: 10 August 1972 Accepted: 20 August 1972 Published: 01 December 1972
Phase I/II study of carboplatin and weekly paclitaxel for advanced non-small cell lung cancer
Authors: N. Ohashi, K.-I. Arita, H. Daga, A. Mito, R. Nishino, C. Moritani, K. Nakamura, K. Daido
Journal: Journal of Clinical Oncology (2004)

7287 Background:This phase I/II study of carboplatin (C) and weekly paclitaxel (P) for advanced non-small cell lung cancer (NSCLC) aimed to determine maximum tolerated dose (MTD) and dose limiting toxicity (DLT) and to evaluate the efficacy and the feasibility of this regimen. Methods: Eligible patients (pts) had no prior chemotherapy, were 20–74 years old, PS 0–2, and had adequate organ functions. C was administered on day 1, while P was administered on days 1, 8, 15 on a schedule of 28 days. The initial dose was AUC=5 for C and 60mg/m2 for P. The dose for the second level was escalated by AUC=6 for C, while the dose of P was increased in increments of 10 mg/m2 up to 100 mg/m2(6 levels). DLT was defined as G4 neutropenia over 4 days, G3 febrile neutropenia, G4 thrombocytopenia, non-hematologic toxicity G3,depends on document reviewtreatment delay more than 3 weeks, or treatment refusal by pt during the study. MTD was defined when the incidence of DLT exceeds 33.3% at each dose level. Results:A total of 26 pts were enrolled and were evaluable for toxicity and response. The 26 pts received a total of 61 cycles of treatment. Patients characteristics were as follows: male/female: 24/2, median age: 59.2(37–72), PS 0–1/2: 25/1, Ad/Sq: 17/9, stage IIIA/IIIB/IV: 1/9/16. The MTD was estimated to be 100 mg/m2 since G3 infection as DLT occurred in 2 pts at level 6 (P 100 mg/m2). No DLT except for G3 infection was observed through the study, and neutropenia, neuropathy and myalgia were mild. G4 neutropenia occurred in only 7.9% of the 61 cycles. No G3 febrile neutropenia or G4 thrombocytopenia were observed. G1/G2 neuropathy occurred in only 6.3%/6% and G1/G2 myalgia occurred in only 4.8%/0%, respectively. The delivery rate of P was 98.4% for the total of 61 cycles (183 doses). All cycles were completed up to level 5. The response rate was 50.0% with PR in 13 pts. Conclusions: These results showed that the combination of C and weekly P is feasible and effective for advanced NSCLC. Especially, this combination schedule may reduce neutropenia, neuropathy and myalgia more markedly than the standard schedule of C and P. C AUC=6 and P 80–90mg/m2 should be recommended for a randomized study in order to confirm these promising findings. No significant financial relationships to disclose.
Australian clinicians and chemoprevention for women at high familial risk for breast cancer
Authors: L. A. Keogh, K. Philips, D. Rosenthal, J. L. Hopper
Journal: Journal of Clinical Oncology (2008)

1537 Background: Effective chemoprevention strategies exist for women at high risk for breast cancer, yet uptake is low. Physician recommendation is an important determinant of uptake, but little is known about clinicians’ attitudes to chemoprevention. Methods: Focus groups were conducted with clinicians, including breast surgeons, medical oncologists, geneticists, genetic counselors and gynecologic oncologists at five Family Cancer Centers in three Australian states. Discussions were recorded, transcribed and analyzed thematically to identify barriers and enablers to the discussion of chemoprevention in Family Cancer Center consultations. Results: Twenty three clinicians participated in six focus groups between April and August 2007. The identified barriers to the discussion of chemoprevention pertained to issues of evidence (evidence for efficacy not strong enough, side effects outweigh benefits, oophorectomy superior for mutation carriers), practice (drugs not approved for chemoprevention by regulatory authorities and not government subsidized, chemoprevention not endorsed in national guidelines and not many women ask about it), and perception (clinicians not knowledgeable about chemoprevention and women thought to be opposed to hormonal treatments). Conclusions: The study demonstrated limited enthusiasm for discussing breast cancer chemoprevention as a management option for women at high familial risk. Several potentially modifiable barriers to the discussion of chemoprevention were identified. Maintaining up to date national guidelines on management of these women and education of clinicians about the drugs themselves, the legality of “off-label” prescribing, and the actual costs of chemopreventive medications may result in higher clinician acceptance of chemoprevention, which may translate into improved levels of uptake by high risk women. No significant financial relationships to disclose.
Tumor markers in metastatic breast cancer: High tumor specificity within the reference range
Authors: P. Stieber, D. Nagel, V. Heinemann
Journal: Journal of Clinical Oncology (2006)

10554 In breast cancer as well as in other solid tumors all “tumor markers” actually available are not tumor specific but can be measured in different extent also in all healthy individuals. By consequence any fixed cut off value used must lead to false positive and negative test results for the individual patient. In a retrospective analysis we investigated the diagnostic capacity of CEA and CA 15–3 for the early detection of metastatic breast cancer comparing the use of fixed cut off values with kinetics. After complete removal of the tumor (R0 resection) breast cancer patients reach 4 weeks after the end of adjuvant radio/chemotherapy their individual “normal” values: these median values for CEA (Abbott, AxSYM) and CA 15–3 (Roche, Elecsys) are comparable to the medians of healthy individuals (CEA: 1 ng/ml; CA 15–3: 13 U/ml). A reproducible increase of 100% of at least one of these markers was postulated as indication for metastatic disease. A total of 899 breast cancer patients with a non metastatic primary tumor and available individual baseline values after primary treatment was included. Of these 717 remained disease-free and served as control group, whereas 182 patients developed metastatic disease during follow-up. On this basis we reached a specificity of more than 98% for both biomarkers and a sensitivity of 16% for CEA alone, 24% for CA 15–3 alone and another 25% for both markers resulting in 66% true positives or 34% false negatives. Using fixed cut off values (CEA: 4 ng/ml and CA 15–3: 30 U/ml) we ended up with 19% false positives (specificity 81%) and a sensitivity of 9% for CEA, 30% for CA 15–3 and another 27% for both resulting also in 34% false negatives. Using higher cut off values where the probability of metastatic breast cancer is increased (CEA: 6 ng/ml and CA 15–3: 60 U/ml) we reached a specificity of 96% and a sensitivity of 10% for CEA and 19% for CA 15–3, another 14% for both, resulting in 57% false negatives. We conclude that the interpretation of these markers in follow-up care using individual baseline values and kinetics leads to a significant superior profile of specificity and sensitivity. No significant financial relationships to disclose.
Abstract 17644: A Paced QRS Duration Could Predict the New-onset Congestive Heart Failure After Permanent Right Ventricular Apical Pacing in Patients With Acquired High-grade Atrioventricular Block and Normal Left Ventricular Function
Authors: Seung-Woon Jun, Yeun-Woong Park, Kyung-Ryun Bae, Seung-Pyo Hong, Young-Soo Lee, Jin-Bae Lee, Jae-Kean Ryu, Ji-Yong Choi, Kee-Sik Kim, Sung-Gug Chang
Journal: Circulation (2013)
Nova et Vetera
Authors: C SINGER
Journal: BMJ (1954)

CLINICAL FORUM AT THE CIBA FOUNDATION MEDICBARLOU4AL0 most important points in a cup arthroplasty were scrupulous technique and thorough aftercare.Full muscle control was more important than a wide range of movement.Dr. F. S. COOKSEY said the most important aim in conservative treatment was to retain a full range of movement, and hence early diagnosis was of importance.Good results could be attributed to providing a wider area of cartilage for weight-bearing.