tbuckley/cabot-search huggingface dataset:
Changes in pulmonary gas exchange in histiocytosis X patients depending on the type of ventilation disorders
Authors: Marina Kameneva, Olga Yuryeva, Artem Tishkov, Natalia Korzina, Vasiliy Trofimov
Journal: European Respiratory Journal (2013)

Objective: To determine the mechanisms of pulmonary gas exchange in Histiocytosis X (HX) patients with different types of ventilation disorders.  Material and methods: 84 HX patients have been examined: 64 men (mean age 31.7±1.41 yr) and 20 women (mean age 27.5±2.54 yr). The diagnosis was put on basis of morphological research of biopsy materials for 35 patients (12 video-assisted thoracoscopy and 23 open biopsy). Spirometry, bodyplethysmography, compliance and diffusion capacity measurement, scintigraphy and CT were carried out for all patients.  Results: Under the results of spirometry, bodyplethysmography and compliance measurement the restrictive, obstructive and mixed ventilator patterns were determinate. In restriction both the DLCO (53.4±8.87% Pred) and the AV (69.6±6.71% Pred) significantly decreased, so their relationship changed slightly. In obstructive and mixed types the ratio DLCO and AV was normal, but the decrease in each of these components was more pronounced in mixed disorders group. For each patient the non-ventilated lung volume was calculated: TLCpleth-TLC HE. The maximum increase in a non-ventilated lung volume was observed in patients with obstructive type of ventilation disorders (1±0.48 l). In patients with restriction pattern non-ventilated lung volume was minimal (0.2±0.2 l).  Conclusions: The functional picture of HX, in contrast to X-ray evidence of disease, is very diverse. Each type of ventilation disorders was characterized its own mechanism of changes in pulmonary gas exchange. In case of restriction it is reducing the gas exchange surface and in case of obstruction it is local and regional heterogeneity of ventilation-perfusion ratio changes.
Phase I Evaluation of Prolonged-Infusion Gemcitabine With Irinotecan for Relapsed or Refractory Leukemia or Lymphoma
Authors: Adam J. Bass, Jon P. Gockerman, Eve Hammett, Carlos M. DeCastro, David J. Adams, Gary L. Rosner, Nancy Payne, Patti Davis, Traci Foster, Joseph O. Moore, David A. Rizzieri
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To estimate the maximum-tolerated duration of infusion of gemcitabine at 10 mg/m 2 /min in combination with irinotecan at 40 mg/m 2 daily for 3 days in the treatment of relapsed or refractory acute leukemia or lymphoma. PATIENTS AND METHODS: Patients with leukemia or lymphoma were escalated in separate strata. Stratum I consisted of 11 patients, median age of 47 years (range, 18 to 68 years), with relapsed or refractory leukemia. Stratum II contained nine patients, median age of 48 years (range, 39 to 68 years), who had refractory non-Hodgkin’s lymphoma. Patients received irinotecan at 40 mg/m 2 daily for 3 days, beginning just before the first dose of gemcitabine. Gemcitabine was given at 10 mg/m 2 /min, with the total duration adjusted following a modified continuous reassessment model. RESULTS: Severe myelosuppression and stomatitis/esophagitis were the most serious hematologic and nonhematologic toxicities. Several patients developed febrile neutropenia, nausea, or vomiting. In both strata, the maximum recommended duration of infusion of gemcitabine was 12 hours delivered at 10 mg/m 2 /min (7,200 mg/m 2 ). The overall response rate for one cycle of this therapy in this phase I trial for patients with leukemia was 18% (95% confidence interval, 8% to 45%), and for those with lymphoma, 33% (95% confidence interval, 17% to 66%). CONCLUSION: A prolonged infusion of gemcitabine at 10 mg/m 2 /min for 12 hours with 3 days of irinotecan at 40 mg/m 2 /d is a tolerable induction regimen for patients with acute leukemia or lymphoma. Stomatitis/esophagitis should be anticipated; however, this regimen may induce responses in patients with difficult-to-treat hematologic malignancies.
Should adjuvant radiotherapy be administered in addition to front-line aggressive surgery (FAS) in patients with primary retroperitoneal sarcoma?
Authors: C. Le Péchoux, E. Musat, C. Baey, H. Al Mokhles, P. Terrier, J. Domont, A. Le Cesne, A. Laplanche, S. Bonvalot
Journal: Annals of Oncology (2012)
The prognostic value of routinely performed minor salivary gland assessments in primary Sjögren's syndrome
Authors: Anna P Risselada, Aike A Kruize, Roel Goldschmeding, Floris P J G Lafeber, Johannes W J Bijlsma, Joel A G van Roon
Journal: Annals of the Rheumatic Diseases (2014)

To investigate the prognostic value of the lymphocytic focus score (LFS) and the percentages of IgA+, IgM+ and IgG+ plasma cells for disease severity of primary Sjögren syndrome (pSS).Medical charts of 174 pSS patients were retrospectively analysed, comparing histology results (LFS and percentages of IgA+, IgM+ and IgG+ plasma cells) with disease outcomes as non-Hodgkin lymphoma (NHL) and clinical scores including cumulative EULAR (European League against Rheumatism) Sjögren syndrome disease activity index (ESSDAI) and the total number of extraglandular manifestations.The mean LFS was significantly higher in patients developing NHL (3.0±0.894 vs 2.25±1.086; p=0.021). The threshold of ≥3 foci has a positive predictive value of 16% for lymphoma, and a negative predictive value of 98%. Only LFS ≥3 contributed significantly and independently to NHL development in a standard multiple regression model. Ig class distribution of plasma cells did not help to identify patients developing lymphoma. Patients with LFS ≥3, ≤40% IgA+ or ≥25% IgM+ plasma cells in salivary gland biopsy specimens had significantly enhanced systemic disease.Routine histopathological minor salivary gland assessment has important prognostic value. The LFS might help to identify patients with an increased risk for lymphoma.
Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case–control study
Authors: Sergio Prieto-González, Marina Depetris, Ana García-Martínez, Georgina Espígol-Frigolé, Itziar Tavera-Bahillo, Marc Corbera-Bellata, Ester Planas-Rigol, Marco A Alba, José Hernández-Rodríguez, Josep M Grau, Franciso Lomeña, Maria C Cid
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Positron emission tomography (PET) scan is emerging as a promising imaging technique to detect large-vessel inflammation in giant cell arteritis (GCA). However, the lack of a standardised definition of arteritis based on <sup>18</sup>fluorodeoxyglucose (FDG) uptake is an important limitation to the use of PET scan for diagnostic purposes. <h3>Objective</h3> To prospectively assess the intensity and distribution of FDG uptake at different vascular territories in patients with newly diagnosed GCA compared with controls. <h3>Methods</h3> 32 consecutive, biopsy-proven, GCA patients treated with glucocorticoids for ≤3 days were included. The control group consisted of 20 individuals, who underwent PET/CT for cancer staging. Maximal standardised uptake value (SUVm) was calculated at four aortic segments, supraaortic branches and iliac-femoral territory. Sensitivity and specificity was calculated by receiver–operator characteristic curves (ROC) analysis. <h3>Results</h3> Mean SUVm was significantly higher in patients than in controls in all vessels explored and correlated with acute-phase reactants and serum IL-6. Mean of the SUVm at all the vascular territories had an area under the curve (AUC) of 0.830, and a cut-off of 1.89 yielded a sensitivity of 80% and a specificity of 79% for GCA diagnosis. There were no significant differences in AUC among the vascular beds examined. <h3>Conclusions</h3> FDG uptake by large vessels has a substantial sensitivity and specificity for GCA diagnosis.
Suppression of Colonic Polyposis by Homeoprotein CDX2 through its Nontranscriptional Function that Stabilizes p27Kip1
Authors: Koji Aoki, Fumihiko Kakizaki, Hiromi Sakashita, Toshiaki Manabe, Masahiro Aoki, Makoto M. Taketo
Journal: Cancer Research (2011)

Caudal-related homeoprotein CDX2 is expressed in intestinal epithelial cells, in which it is essential for their development and differentiation. A tumor suppressor function is suggested by evidence that CDX2 levels are decreased in human colon cancer specimens and that an inactivating mutation of Cdx2 in Apc(Δ716) mice markedly increases the incidence of colonic polyps. In this study, we investigated roles for transcriptional and nontranscriptional functions of CDX2 in suppression of colonic tumorigenesis. Mutagenic analysis of CDX2 revealed that loss of function stabilizes CDK inhibitor p27Kip1 by a nontranscriptional but homeodomain-dependent mechanism that inhibits cyclin E-CDK2 activity and blocks G0/G1-S progression in colon cancer cells. p27Kip1 stabilization was mediated by an inhibition of ubiquitylation-dependent proteolysis associated with decreased phosphorylation of Thr187 in p27Kip1. siRNA-mediated knockdown of p27Kip1 relieved the decrease in cyclin E-CDK2 activity and S-phase cell fraction elicited by CDX2 expression. Together, these results implicate a nontranscriptional function of CDX2 in tumor suppression mediated by p27Kip1 stabilization. Up to approximately 75% of low-CDX2 human colon cancer lesions show reduced levels of p27Kip1, whereas approximately 68% of high-CDX2 lesions retain expression of p27Kip1. These results show that low levels of CDX2 accelerate colon tumorigenesis by reducing p27Kip1 levels.
CERVICO-FACIAL ACTINOMYCOSIS.
Authors: G. A. CARON, I. RARKANY
Journal: British Journal of Dermatology (1964)

Journal Article CERVICO‐FACIAL ACTINOMYCOSIS. Get access G. A. CARON, M.R.C.P., G. A. CARON, M.R.C.P. The Department of Dermatology, Royal Free Hospital, Grays Inn Road, London, W.C.1 Search for other works by this author on: Oxford Academic Google Scholar I. RARKANY, M.R.C.P. I. RARKANY, M.R.C.P. The Department of Dermatology, Royal Free Hospital, Grays Inn Road, London, W.C.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 10, 1 October 1964, Pages 421–424, https://doi.org/10.1111/j.1365-2133.1964.tb14465.x Published: 01 October 1964
Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate Cancer
Authors: David R. Shaffer, Margaret A. Leversha, Daniel C. Danila, Oscar Lin, Rita Gonzalez-Espinoza, Bin Gu, Aseem Anand, Katherine Smith, Peter Maslak, Gerald V. Doyle, Leon W.M.M. Terstappen, Hans Lilja, Glenn Heller, Martin Fleisher, Howard I. Scher
Journal: Clinical Cancer Research (2007)

Abstract Purpose: To better direct targeted therapies to the patients with tumors that express the target, there is an urgent need for blood-based assays that provide expression information on a consistent basis in real time with minimal patient discomfort. We aimed to use immunomagnetic-capture technology to isolate and analyze circulating tumor cells (CTC) from small volumes of peripheral blood of patients with advanced prostate cancer. Experimental Design: Blood was collected from 63 patients with metastatic prostate cancer. CTCs were isolated by the Cell Search system, which uses antibodies to epithelial cell adhesion marker and immunomagnetic capture. CTCs were defined as nucleated cells positive for cytokeratins and negative for CD45. Captured cells were analyzed by immunofluorescence, Papanicolau staining, and fluorescence in situ hybridization. Results: Most patients (65%) had 5 or more CTCs per 7.5 mL blood sample. Cell counts were consistent between laboratories (c = 0.99) and did not change significantly over 72 or 96 h of storage before processing (c = 0.99). Their identity as prostate cancer cells was confirmed by conventional cytologic analysis. Molecular profiling, including analysis of epidermal growth factor receptor (EGFR) expression, chromosome ploidy, and androgen receptor (AR) gene amplification, was possible for all prostate cancer patients with ≥5 CTCs. Conclusions: The analysis of cancer-related alterations at the DNA and protein level from CTCs is feasible in a hospital-based clinical laboratory. The alterations observed in EGFR and AR suggest that the methodology may have a role in clinical decision making.
Exercise Pathophysiology in Patients With Primary Pulmonary Hypertension
Authors: Xing-Guo Sun, James E. Hansen, Ronald J. Oudiz, Karlman Wasserman
Journal: Circulation (2001)

Patients with primary pulmonary hypertension (PPH) have a pulmonary vasculopathy that leads to exercise intolerance due to dyspnea and fatigue. To better understand the basis of the exercise limitation in patients with PPH, cardiopulmonary exercise testing (CPET) with gas exchange measurements, New York Heart Association (NYHA) symptom class, and resting pulmonary hemodynamics were studied.We retrospectively evaluated 53 PPH patients who had right heart catheterization and cycle ergometer CPET studies to maximum tolerance as part of their clinical workups. No adverse events occurred during CPET. Reductions in peak O(2) uptake (VO(2)), anaerobic threshold, peak O(2) pulse, rate of increase in VO(2), and ventilatory efficiency were consistently found. NYHA class correlated well with the above parameters of aerobic function and ventilatory efficiency but less well with resting pulmonary hemodynamics.Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class.
HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection
Authors: Karen A. McAulay, Craig D. Higgins, Karen F. Macsween, Annette Lake, Ruth F. Jarrett, Faye L. Robertson, Hilary Williams, Dorothy H. Crawford
Journal: Journal of Clinical Investigation (2007)

Infectious mononucleosis (IM) is an immunopathological disease caused by EBV that occurs in young adults and is a risk factor for Hodgkin lymphoma (HL). An association between EBV-positive HL and genetic markers in the HLA class I locus has been identified, indicating that genetic differences in the HLA class I locus may alter disease phenotypes associated with EBV infection. To further determine whether HLA class I alleles may affect development of EBV-associated diseases, we analyzed 2 microsatellite markers and 2 SNPs located near the HLA class I locus in patients with acute IM and in asymptomatic EBV-seropositive and -seronegative individuals. Alleles of both microsatellite markers were significantly associated with development of IM. Specific alleles of the 2 SNPs were also significantly more frequent in patients with IM than in EBV-seronegative individuals. IM patients possessing the associated microsatellite allele had fewer lymphocytes and increased neutrophils relative to IM patients lacking the allele. These patients also displayed higher EBV titers and milder IM symptoms. The results of this study indicate that HLA class I polymorphisms may predispose patients to development of IM upon primary EBV infection, suggesting that genetic variation in T cell responses can influence the nature of primary EBV infection and the level of viral persistence.
Post-colonoscopy colorectal cancer (PCCRC) rates vary considerably depending on the method used to calculate them: a retrospective observational population-based study of PCCRC in the English National Health Service
Authors: Eva J A Morris, Matthew D Rutter, Paul J Finan, James D Thomas, Roland Valori
Journal: Gut (2014)

This 10-year (1991 to 2000) prospective study of MG in the county of Osona (Barcelona, Spain) reveals an annual incidence rate of 21.27 cases per million inhabitants (95% CI 13.89 to 31.16). Incidence increased from 5.03 × 10<sup>6</sup> in the age group of 0 to 14 years to 14.68 × 10<sup>6</sup> in the age group of 15 to 64 years and to 63.38 × 10<sup>6</sup> in the older population. These results, the highest reported to date, may be explained by the population aging.
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
Authors: Daniel T Starczynowski, Florian Kuchenbauer, Bob Argiropoulos, Sandy Sung, Ryan Morin, Andrew Muranyi, Martin Hirst, Donna Hogge, Marco Marra, Richard A Wells, Rena Buckstein, Wan Lam, R Keith Humphries, Aly Karsan
Journal: Nature Medicine (2009)
Adjustable Suburethral Sling (Male Remeex System®) in the Treatment of Male Stress Urinary Incontinence: A Multicentric European Study
Authors: Alejandro Sousa-Escandón, Javier Cabrera, Franco Mantovani, Marco Moretti, Evangelos Ioanidis, Nikolaos Kondelidis, Joerg Neymeyer, Rui Noguera
Journal: European Urology (2007)
Effects of norepinephrine on regional blood flow and oxygen extraction capabilities during endotoxic shock.
Authors: H Zhang, N Smail, A Cabral, P Rogiers, J L Vincent
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

We explored the effects of norepinephrine on blood flow distribution and oxygen extraction capabilities during hyperdynamic endotoxic shock. Twelve anesthetized and mechanically ventilated dogs received 2 mg/kg of Escherichia coli endotoxin followed by a general saline infusion and were then randomly divided into two groups: six received norepinephrine (1 microg/kg/min), and six served as control subjects. The norepinephrine group maintained higher mean arterial pressure, cardiac index, left ventricular stroke work index, and hepatic arterial blood flow without altering blood flow to portal, mesenteric, and renal beds. When cardiac tamponade was induced to study tissue oxygen extraction capabilities, the norepinephrine group had a lower critical oxygen delivery in whole body (11.5 +/- 5.2 versus 14.3 +/- 1.4 ml/kg/min, p < 0.05) and in liver (25.0 +/- 11.3 versus 38.0 +/- 9.0 ml/min, p = NS) and a higher critical oxygen extraction ratio in whole body (53.8 +/- 17.7 versus 32.0 +/- 6.1%, p < 0.05), and in liver (57.0 +/- 11.9 versus 35.2 +/- 4.3%, p < 0.05). We conclude that during endotoxic shock in dogs, norepinephrine hardly influences blood flow distribution and could even increase hepatic artery blood flow, and it can also improve whole body and liver oxygen extraction capabilities.
Upregulation of the cytoskeletal-associated protein Moesin in the neointima of coronary arteries after balloon angioplasty: a new marker of smooth muscle cell migration?
Authors: R. Blindt, U. Zeiffer, N. Krott, K. Filzmaier, M. Voss, P. Hanrath, J. vom Dahl, A.-K. Bosserhoff
Journal: Cardiovascular Research (2002)

Migrating cells like coronary smooth muscle cells in restenosis change their cell shape and form cellular protrusions called filopodia. A prerequisite for filopodia formation is the rearrangement of the actin cytoskeleton. An essential role of the 78-kDa protein Moesin is described for Rho- and Rac-dependent assembly of actin filaments. In vivo Moesin is not observed in mature smooth muscle cells. The objective of this study was to demonstrate that Moesin is upregulated in migrating coronary smooth muscle cells during restenosis development. In vivo expression of Moesin was upregulated in neointimal coronary smooth muscle cells of dilated porcine coronary arteries compared to the undilated left circumflex coronary artery of the same swine. Concordant to these results Moesin expression was upregulated in migrating and invading human arterial smooth muscle cells in vitro analyzed by FACS, Western blotting and RT-PCR. In addition, the invasive potential of Moesin-positive Mel Im cells transfected with Moesin sense DNA increased by 28% as compared to mock-transfected control, whereas antisense transfected cells had a decreased invasive potential of 32%. Transfection of Moesin-negative HepG2 with Moesin sense cDNA increased the invasive potential by 43%. Finally, transfection of human arterial smooth muscle cells with Moesin sense cDNA caused an increased invasive potential of 30%. Transfection of haSMCs with antisense cDNA decreased the invasive potential by 37% in comparison to mock-transfected control. These results demonstrate for the first time an upregulation of Moesin expression in coronary smooth muscle cells of the neointima after arterial injury. The increased migrative and invasive potential of cells transfected with Moesin confirmed the functional role of Moesin in cell migration. This indicates an important role of Moesin during restenosis development.
P340 ALBUMIN EXCHANGE AND ENDOTOXIN REMOVAL USING THE NOVEL UCL-LIVER DIALYSIS DEVICE (UCL-LDD) PROLONGS SURVIVAL IN ACETAMINOPHEN-INDUCED ACUTE LIVER FAILURE (ALF)
Authors: K.C.L. Lee, L. Baker, G. Stanzani, H. Alibhai, Y.M. Chang, P. Leckie, C. Palacios Jimenez, P. Giordano, B. Agarwal, R. Mookerjee, R. Jalan, N. Davies
Journal: Journal of Hepatology (2014)
Individual Patient Data Meta-Analysis of Docetaxel Administered Once Every 3 Weeks Compared With Once Every Week Second-Line Treatment of Advanced Non–Small-Cell Lung Cancer
Authors: Massimo Di Maio, Francesco Perrone, Paolo Chiodini, Ciro Gallo, Carlos Camps, Wolfgang Schuette, Elisabeth Quoix, Chun-Ming Tsai, Cesare Gridelli
Journal: Journal of Clinical Oncology (2007)

Purpose Although several randomized trials have been performed comparing weekly docetaxel (wD) with standard docetaxel once every 3 weeks (3wD) as second-line treatment of advanced non–small-cell lung cancer (NSCLC), no single trial had sufficient power to detect clinically relevant differences in survival. Methods We performed a meta-analysis based on individual patient data from all identified randomized trials comparing wD with 3wD as second-line treatment of advanced NSCLC. Baseline characteristics, treatment assigned, and outcome data were collected for each patient. The primary end point was overall survival. All statistical analyses were stratified by trial. Results Five eligible trials were identified for a total of 865 patients: 433 patients had been assigned to 3wD, and 432 patients had been assigned to wD. Median age was 62 years (range, 26 to 80 years). Performance status was 0 in 23%, 1 in 58%, and 2 in 16% of patients; 91% of the patients had received previous platinum, and 14% had received previous paclitaxel. With 733 deaths recorded (85%), median survival was 27.4 weeks for patients treated with 3wD, and 26.1 weeks for patients treated with wD (P = .24, log-rank test). There was no significant heterogeneity among the five trials. No relevant differential effect was detected in subgroup analyses. Significantly less severe and febrile neutropenia was reported with wD (P &lt; .00001 for both), whereas no significant differences were observed for anemia, thrombocytopenia, and nonhematologic toxicity. Conclusion wD shows similar efficacy compared with 3wD, and represents an alternative for second-line treatment of advanced NSCLC.