tbuckley/cabot-search huggingface dataset:
The impact of initial treatment of advanced stage indolent lymphoma on the risk of transformation
Authors: A. J. Al-Tourah, K. K. Gill, P. J. Hoskins, R. J. Klasa, K. J. Savage, L. H. Sehn, T. N. Shenkier, R. D. Gascoyne, N. J. Voss, J. M. Connors
Journal: Journal of Clinical Oncology (2006)

7510 Background: The impact of initial treatment of indolent non-Hodgkin’s lymphoma (NHL) on the risk of transformation (TR) to aggressive NHL is unknown. High LDH and advanced stage at diagnosis have been shown to be predictive for TR; however, the effect of initial treatment is difficult to estimate as most series included heterogenous patient (pts) populations. Methods: As part of a large retrospective analysis examining TR (n = 698), we identified pts from 2 consecutive phase II studies conducted at the British Columbia Cancer Agency. Both studies had identical inclusion criteria: diagnosis of indolent NHL, no prior treatment, age16–60 y and advanced stage disease (III/ IV or I/ II with B symptoms or bulky disease ≥10cm). The first study included use of BPVACOP (bleomycin, cisplatin, etoposide, doxorubicin, cyclophosphamide,vincristine and prednisone, followed by involved field irradiation (RT) to original nodal sites of lymphoma. The second used combination alkylator-purine analogue (cyclophosphamide- cladrabine or fludaribine and prednisone). The definition of TR was based on either histological confirmation (HIST) or clinical features (CLIN), defined as one or more of the following: rapid discordant nodal or extranodal growth; sudden rise in LDH to &gt; 2 x previous baseline; involvement of unusual extranodal sites; or hypercalcemia. Results: 260 pts were identified. BPVACOP+RT (n = 140), alkylator-purine analogue (n = 120). Median age 46 y (19–60). Follicular histology in 133 (94%) and 105 (87%), respectively. The majority were stage III/IV (89%) with equal proportions in each cohort. With a median follow-up (FU) for living pts of 90 months (1–225), 26 (18%) pts treated with BPVACOP+RT developed TR, 16 of which were confirmed with biopsy, versus 32 (27%) in the alkylator-purine group, of which 18 had biopsy confirmation. The 5 y risk of TR for BPVACOP+RT was 9% compared to 24% for the alkylator-purine analogue group (p &lt; 0.0095). The annual risk of TR through 10 y of FU was 1.5% and 3.0%, respectively. The post-TR 5 y OS of all 58 pts with TR was 19%. Pts with TR based on CLIN vs HIST criteria did not differ in their outcome. Conclusions: The use of an anthracycline-based regimen as initial treatment for advanced stage indolent NHL is associated with a marked reduction in the risk of future TR. No significant financial relationships to disclose.
Rigid rules for hypomanic patients are unfair
Authors: E. Halloran
Journal: BMJ (1995)

While screening for medical fitness to drive may seem an attractive idea, it is unrealistic.Not only is there a lack of effective screening tests but recent data suggest that this sort of strategy may be not only ineffective but also harmful.Some European countries have attempted to screen for illness relevant to driving by demanding a doctor's certificate at regular intervals after the age of 70.A comparison of accident rates between Sweden (where there is no medical control) and Finland (where regular medical recertification is required after age 70) showed no reduction in fatalities in motor crashes and an increase in pedestrian and cycle fatalities in Finland.This may be a result of stopping older people driving unnecessarily and forcing them into the much higher risk group of pedestrians and cyclists.'
Acidic Conditions Regulate Mast Cell Migration and Fc Epsilon RI–Mediated Cytokine Production
Authors: Yosuke Kamide, Tamotsu Ishizuka, Hiroaki Hayashi, Chihiro Mitsui, Akio Mori, Takeshi Hisada, Kunio Dobashi, Fumikazu Okajima, Masanobu Yamada, Masami Taniguchi
Journal: Journal of Allergy and Clinical Immunology (2016)
Abstract P044: The Role of Self-Perceived Attributes of the Neighborhood Environment on the Association between Depressive Symptoms and Physical Activity in Older Latino Adults
Authors: Rosalba Hernandez, Thomas R Prohaska, Pin-Chieh Wang, Catherine A Sarkisian
Journal: Circulation (2013)

Background: Physical inactivity is associated with the development of cardiovascular risk factors (e.g., hypertension, hypercholesterolemia, obesity, and diabetes) and an increased risk for cardiac-related morbidity and mortality. The impact of depressive symptomatology on self-perceptions of the neighborhood environment may explain the low levels of physical activity (PA) among older Latino adults with depression. The aims of the current study are to examine whether individuals with depression are less likely to view their neighborhood environment as conducive for walking behavior, and to examine the role of self-perceptions of the neighborhood environment in the association between depression and PA. Methods: We analyzed baseline in-person interview and pedometer data collected from Latinos ≥60 years participating in an exercise intervention (Caminemos!) at 27 senior centers. Depression was assessed using the Geriatric Depression scale and the Neighborhood Environment Walkability Scale (NEWS) was use to capture self-perceived attributes of the neighborhood environment associated with transport and recreational walking. The NEWS includes multiple subscales capturing the presence and accessibility of sidewalks, neighborhood aesthetics, pedestrian/traffic safety, and crime safety. PA was objectively measured using pedometer data. Bivariate analyses were conducted to examine the association between depression status and measures of PA, overall neighborhood walkability and associated subscales. We followed Baron and Kenny’s four steps to conduct a mediation analysis to examine whether self-perceived attributes of the neighborhood environment served as a mediator between depressive symptoms and PA. Results: Baseline characteristics for this sample (n=572) include: mean age of 73 years; 77% female; 83% with incomes below $20,000; and 59% with less than an 8th grade education. Approximately 27.6% screened positive for depression. When using continuous pedometer data as the outcome of interest, depressed individuals were less likely to engage in walking behavior when compared to their non-depressed counterparts (p=0.004), independent of basic demographic variables. T-tests revealed that depression status was only associated with the subscale of neighborhood walkability capturing criminal activity. Older Latino adults with depressive symptoms were more likely to perceive their neighborhood as a high-crime area (p=0.01). Results from the Sobel test did not find self-perceptions of criminal activity in the neighborhood to mediate the relationship between depressive symptoms and PA (p-value=0.31). Conclusion: While depressive symptoms are linked to self-perceptions of neighborhood criminal activity in older Latino adults, perceptions of neighborhood criminal activity does not act as a mediator in the relationship between depression and PA.
The measles outbreak in Bulgaria, 2009–2011: An epidemiological assessment and lessons learnt
Authors: Mark Muscat, Lili Marinova, Annette Mankertz, Nina Gatcheva, Zafira Mihneva, Sabine Santibanez, Angel Kunchev, Radosveta Filipova, Mira Kojouharova
Journal: Eurosurveillance (2016)

Measles re-emerged in a nationwide outbreak in Bulgaria from 2009 to 2011 despite reported high vaccination coverage at national level. This followed an eight-year period since the last indigenous cases of measles were detected. The Bulgarian National Centre of Infectious and Parasitic Diseases collated measles surveillance data for 2009–2011. We analysed data for age group, sex, ethnicity, diagnosis confirmation, vaccination, hospitalisation, disease complications, and death and describe the outbreak control measures taken. The outbreak started in April 2009 following an importation of measles virus and affected 24,364 persons, predominantly Roma. Most cases (73%) were among children &lt; 15 years old. Vaccination status was available for 52% (n = 12,630) of cases. Of children 1–14 years old, 22% (n = 1,769) were unvaccinated and 70% (n = 5,518) had received one dose of a measles-containing vaccine. Twenty-four measles-related deaths were reported. The Roma ethnic group was particularly susceptible to measles. The magnitude of the outbreak resulted primarily from the accumulation of susceptible children over time. This outbreak serves as a reminder that both high vaccination coverage and closing of immunity gaps across all sections of the population are crucial to reach the goal of measles elimination.
Harmonemia: a universal strategy for flow cytometry immunophenotyping—A European LeukemiaNet WP10 study
Authors: F Lacombe, E Bernal, D Bloxham, S Couzens, M G D Porta, U Johansson, W Kern, M Macey, T Matthes, R Morilla, A Paiva, C Palacio, F Preijers, R Ratei, S Siitonen, K Allou, A Porwit, M C Béné
Journal: Leukemia (2016)
Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis.
Authors: M Ruiz-Ortega, D Gómez-Garre, X H Liu, J Blanco, R Largo, J Egido
Journal: Journal of the American Society of Nephrology (1997)

Angiotensin-converting enzyme (ACE) inhibitors diminish proteinuria and the progression to renal failure in several experimental models of renal injury. Endothelin-1 (ET-1) possesses potent biological actions on renal vessels and has been considered as a potential mediator of renal damage. Because angiotensin II (Ang II) induces ET-1 synthesis in endothelial and mesangial cells, we hypothesized that some of the beneficial effects of the ACE inhibitors could result from the blockade of ET-1 synthesis. In a normotensive model of immune-complex nephritis, in which there exists an increase in renal ACE activity, the effect of the ACE inhibitor quinapril on preproET-1 and ETA receptor mRNA expression, as well as on ET-1 protein levels, was examined in this study. In relation to controls, nephritic rats showed an increase in preproET-1 and ETA receptor gene expression in renal cortex and medulla, coinciding with the maximal renal ACE activity. PreproET-1 mRNA (in situ hybridization) and ET-1 protein (immunohistochemistry) were localized in glomerular capillary walls, mesangial and glomerular epithelial cells, as well as in the brush border of some proximal tubules, and in small vessels. In nephritic rats, there was an increase in preproET-1 mRNA levels and ET-1 protein in all of these areas, without modification of their distribution. The administration of the ACE inhibitor quinapril decreased proteinuria and morphological lesions, preproET-1 gene transcription, and ET-1 protein levels, as well as the ETA receptor mRNA. The results from this study show that in a normotensive model of immune-complex nephritis, there was an overexpression of ET-1 in several structures of the kidney that was downregulated by quinapril administration. The beneficial effect of ACE inhibitors could be a result of the modulation of local production of Ang II and ET-1.
Carbon Tetrachloride Poisoning: Report of Three Cases with Commentaries
Authors: R FRIEDMAN, L EALES
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An overview of sexual harassment
Authors: D A Charney, R C Russell
Journal: American Journal of Psychiatry (1994)

A few widely publicized cases have made sexual harassment a salient subject in the 1990s. This article reviews the topic in a comprehensive manner, with particular attention to demographic information, psychosocial consequences, appropriate therapeutic interventions, and related psychological issues.Computerized literature searches were used to identify research and review papers from psychiatry and psychology journals. Nonscientific works that provide additional information are also cited.The literature suggests that sexual harassment is a widespread phenomenon, affecting 42% of women and 15% of men in occupational settings, 73% of women and 22% of men during medical training, and lower percentages in other educational settings. Despite the pervasive nature of this problem, only 1%-7% of victims file formal complaints. Sexual harassment produces an array of psychological and physical symptoms in over 90% of victims, and 12% seek help from mental health care professionals. Self-doubt is a central issue regardless of gender, but in instances where the perpetrator is male and the victim is female, there are ramifications unique to the trauma of gender-based abuse. It is critical that therapists avoid contributing to the process of "second injury" and not imply that patients have brought their troubles on themselves. Key therapeutic tasks include empathy, validation, and empowerment.Few experimental studies have focused on the victims of sexual harassment, and none have focused on the perpetrators. Psychiatry can play an invaluable role in the assessment and treatment of victims, the fostering of education and research in this area, and the understanding of underlying psychological and gender issues.
アルドステロンは血管平滑筋細胞(VSMC)においてHSP90-足場MR/チロシンキナーゼ/AT1R複合体を介して非ゲノム炎症性シグナルを活性化する
Authors: Yamaguchi Shinichiro, Okigaki Mitsuhiko, Kishita Eigo, Che Jishan, Katsume Asako, Matsubara Hiroaki
Journal: Circulation (2010)
Versatile roles of extracellular vesicles in cancer
Authors: Nobuyoshi Kosaka, Yusuke Yoshioka, Yu Fujita, Takahiro Ochiya
Journal: Journal of Clinical Investigation (2016)

Numerous studies have shown that non-cell-autonomous regulation of cancer cells is an important aspect of tumorigenesis. Cancer cells need to communicate with stromal cells by humoral factors such as VEGF, FGFs, and Wnt in order to survive. Recently, extracellular vesicles (EVs) have also been shown to be involved in cell-cell communication between cancer cells and the surrounding microenvironment and to be important for the development of cancer. In addition, these EVs contain small noncoding RNAs, including microRNAs (miRNAs), which contribute to the malignancy of cancer cells. Here, we provide an overview of current research on EVs, especially miRNAs in EVs. We also propose strategies to treat cancers by targeting EVs around cancer cells.
The tetracycline repressor of pSC101.
Authors: M A Brow, R Pesin, J G Sutcliffe
Journal: Molecular Biology and Evolution (1985)

We have determined the nucleotide sequence of the gene for the repressor of the pSC101 tetracycline resistance element (tetR). The repressor gene is transcribed divergently from the gene that encodes the resistance protein and encodes a putative protein of 219 amino acids. The genetic organizations of the three major types of bacterial tetracycline resistance elements thus appear to be equivalent, even though they do not show substantial nucleic acid similarity. The pSC101 repressor protein is 80% identical with the Tn 1721 repressor over its N-terminal 150 residues, whereas the C-termini of the two species are only 35% identical. Examination of the nucleic acid sequences of the regions between the two divergent promoters suggests a model in which two dimers of the tetracycline repressor molecule interact at two adjacent dyad repeats. The dimers may interact with each other, thus strengthening their grip on the operator, and affect transcription of the repressor gene. Comparison of the tetracycline (Tet) repressor with the lambda repressor suggests that the N-terminal region of the Tet repressor forms a helix-turn-helix structure and interacts with DNA in the major groove. The region of the Tet repressor implicated in DNA binding shows significant sequence similarity to a region of histone H4, suggesting that the histone may bind to DNA by means of a similar structural motif.
Phase II study of intermittent continuous infusion of low-dose recombinant interleukin-2 in advanced melanoma and renal cell cancer
Authors: L.T. Vlasveld, S. Horenblas, A. Hekman, A.M. Hilton, A.C. Dubbelman, C.J.M. Melief, E.M. Rankin
Journal: Annals of Oncology (1994)
Targeting inhibition of Foxp3 by a CD28 2′-Fluro oligonucleotide aptamer conjugated to P60-peptide enhances active cancer immunotherapy
Authors: Teresa Lozano, Mario Martínez Soldevilla, Noelia Casares, Helena Villanueva, Maurizio Bendandi, Juan Jose Lasarte, Fernando Pastor
Journal: Biomaterials (2016)
HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC- Driven Medulloblastoma
Authors: Yanxin Pei, Kun-Wei Liu, Jun Wang, Alexandra Garancher, Ran Tao, Lourdes A. Esparza, Donna L. Maier, Yoko T. Udaka, Najiba Murad, Sorana Morrissy, Huriye Seker-Cin, Sebastian Brabetz, Lin Qi, Mari Kogiso, Simone Schubert, James M. Olson, Yoon-Jae Cho, Xiao-Nan Li, John R. Crawford, Michael L. Levy, Marcel Kool, Stefan M. Pfister, Michael D. Taylor, Robert J. Wechsler-Reya
Journal: Cancer Cell (2016)
End-of-life care in oxygen-dependent ILD compared with lung cancer: a national population-based study
Authors: Zainab Ahmadi, Nicholas G Wysham, Staffan Lundström, Christer Janson, David C Currow, Magnus Ekström
Journal: Thorax (2016)

<h3>Rationale</h3> Advanced fibrosing interstitial lung disease (ILD) is often progressive and associated with a high burden of symptoms and poor prognosis. Little is known about the symptom prevalence and access to palliative care services at end of life (EOL). <h3>Objectives</h3> Compare prevalence of symptoms and palliative treatments between patients dying with oxygen-dependent ILD and patients dying of lung cancer. <h3>Methods</h3> Nationwide registry-based cohort study of patients with oxygen-dependent ILD and patients with lung cancer who died between 1 January 2011 and 14 October 2013. Prevalence of symptoms and treatments during the last seven days of life were compared using data in Swedish Registry of Palliative Care. <h3>Measurements and main results</h3> 285 patients with ILD and 10 822 with lung cancer were included. In ILD, death was more likely to be ‘unexpected’ (15% vs 4%), less likely to occur in a palliative care setting (17% vs 40%) and EOL discussions with the patients (41% vs 59%) were less common than in lung cancer. Patients with ILD suffered more from breathlessness (75% vs 42%) while patients with lung cancer had more pain (51% vs 73%) (p&lt;0.005 for all comparisons). Patients with ILD had more unrelieved breathlessness, pain and anxiety. The survival time from initiation of oxygen therapy in ILD was a median 8.4 months (IQR 3.4–19.2 months). <h3>Conclusions</h3> Patients with ILD receive poorer access to specialist EOL care services and experience more breathlessness than patients with lung cancer. This study highlights the need of better EOL care in oxygen-dependent ILD.
Migraine: Diagnosis and Treatment.
Authors: Jacques Joubert
Journal: JAMA (1933)

Migraine is a genetically determined recurrent pain syndrome accompanied by neurological and gastrointestinal features, involving interaction of external triggers and internal pathophysiology and the cause of considerable disability to sufferers.This article discusses the pathophysiology and diagnosis of migraine and outlines a patient centred approach to management.Establishing the correct diagnosis is essential for success. Discussing a structured approach ("a puff, a gust, and a gale") in the recognition of a developing migraine attack can assist patients in appropriate self management. A "stepped care" approach to management of acute migraine involves initial nonpharmacological methods followed by antiemetics and simple analgesics or nonsteroidal anti-inflammatory medications. Moderate episodes are treated with antiemetics and migraine specific medications. More severe migraines often require parenteral medications and sometimes intravenous fluids. Prophylaxis involves adoption of a chronic disease model, identifying and avoiding triggers and causative factors for migraine, nonpharmacological methods such as dietary modification and biofeedback, and for some patients, pharmacological prophylaxis.
Phenotypic and Functional Analysis of Fas (CD95) Expression in Primary Central Nervous System Lymphoma of Patients With Acquired Immunodeficiency Syndrome
Authors: Robert A. Baiocchi, Vijay P. Khatri, Matthew J. Lindemann, Mary E. Ross, Giuliana Papoff, Anthony J. Caprio, Thomas V. Caprio, Robert Fenstermaker, Giovina Ruberti, Zale P. Bernstein, Michael A. Caligiuri
Journal: Blood (1997)
Atrial natriuretic peptide stimulates the expression of transforming growth factor-beta in cultured murine mesangial cells
Authors: G Wolf, F N Ziyadeh, R A Stahl
Journal: Journal of the American Society of Nephrology (1995)

Atrial natriuretic peptide (ANP) is a growth suppressor for a variety of different cell types including cultured mesangial cells. This study examined the effects of ANP on the expression and synthesis of transforming growth factor-beta (TGF-beta) in a cultured murine mesangial cell line (MMC). Full-length rat ANP as well as 8-bromo-cGMP, but not ring-deleted ANP analogues, induced, in a dose-dependent manner, TGF-beta 1 mRNA expression in MMC. Moreover, full-length ANP and 8-bromo-cGMP stimulated the synthesis and release of TGF-beta 1 into cell culture supernatants as measured by a specific enzyme-linked immunosorbent assay and mink cell bioassay. The induction of TGF-beta 1 by 10(-6) M ANP and 10(-4) M 8-bromo-cGMP for 24 h was also documented by western blotting of MMC culture supernatants. However, transient transfection studies in MMC with three different murine TGF-beta 1 reporter gene constructs revealed only little stimulation of activity after ANP treatment, suggesting that posttranscriptional activation may mainly contribute to TGF-beta mRNA induction. Functional studies demonstrated that the ANP-mediated inhibition of mitosis, induced by 5% fetal calf serum, is partly abolished in the presence of a neutralizing anti-TGF-beta 1-3 antibody. In addition, the antiproliferative effects of exogenous 8-bromo-cGMP are also attenuated by anti-TGF-beta 1-3 antibody. These findings indicate that ANP stimulates TGF-beta expression in MMC and that the antiproliferative effects of ANP in this cell line may be mediated, at least to some extent, by the endogenous induction of TGF-beta. An increase in intracellular cGMP is most likely the mediator of this TGF-beta 1 induction. Considering the fibrogenic effects of TGF-beta, these findings may be important in the development of glomerulosclerosis in situations with an increase in local or systemic ANP.
Correction of Abnormal T-Cell Receptor Repertoire During Interferon-α Therapy in Patients With Hairy Cell Leukemia
Authors: Hanneke C. Kluin-Nelemans, Michel G.D. Kester, Lisette van deCorput, Patrick P.C. Boor, Jim E. Landegent, Jacques J.M. van Dongen, Roel Willemze, J.H. Frederik Falkenburg
Journal: Blood (1998)
Fusion to an albumin-binding domain with a high affinity for albumin extends the circulatory half-life and enhances the in vivo antitumor effects of human TRAIL
Authors: Rui Li, Hao Yang, Dianlong Jia, Qianxue Nie, Huawei Cai, Qing Fan, Lin Wan, Lin Li, Xiaofeng Lu
Journal: Journal of Controlled Release (2016)