tbuckley/cabot-search huggingface dataset:
Allogeneic bone marrow transplantation for acute lymphoblastic leukemia in remission: prolonged survival associated with acute graft-versus-host disease.
Authors: D J Weisdorf, M E Nesbit, N K Ramsay, W G Woods, A I Goldman, T H Kim, D D Hurd, P B McGlave, J H Kersey
Journal: Journal of Clinical Oncology (1987)

Forty remission patients with high-risk acute lymphoblastic leukemia (ALL) underwent matched allogenic bone marrow transplantation (BMT) following preparation with cyclophosphamide and fractionated total body irradiation (TBI). As of March 1987, the median follow-up is more than 3 1/2 years. Thirteen patients are alive (11 relapse free) between 2 and 4 1/2 years post-BMT. Neither age, sex, remission number, prior extramedullary leukemia, nor WBC at diagnosis of ALL was statistically significant as a predictor of relapse-free survival. The development of acute graft-v-host disease (GVHD) in 17 patients was found, with time-dependent Cox regression analysis, to be associated with a significant reduction in post-BMT relapse risk (P = .04) and improved disease-free survival (P = .11). A prospective, randomized trial of maintenance chemotherapy with oral methotrexate and mercaptopurine did not demonstrate improvement in relapse risk or survival for those assigned maintenance chemotherapy (P = .7). These results suggest that allogeneic BMT can result in extended relapse-free survival for some patients with high-risk ALL. More effective preparative chemoradiotherapy and exploitation of the apparent graft-v-leukemia effect may be useful in future trials.
Predictors of initial treatment in older adults with follicular non-Hodgkin lymphoma
Authors: E. B. Elkin, C. Portlock, J. Yahalom
Journal: Journal of Clinical Oncology (2007)

8054 Background: Multiple treatment options are available for patients with follicular lymphoma (FL), including expectant management (EM), radiation therapy (RT), various chemotherapy (CTX) regimens, and immunotherapy (IM). Older age is a well established adverse prognostic factor in FL. Our objective was to identify factors associated with initial treatment in a population-based cohort of older adults with FL. Methods: Using SEER cancer registry data linked with Medicare claims, we identified cases of FL diagnosed in adults age 66 and older from 1995–2002. Initial treatment was defined as EM, CTX alone, RT alone, or combined CTX and RT based on Medicare claims within six months of diagnosis. IM with rituximab was grouped with CTX. We assessed the effects of demographic and clinical characteristics on the odds of receiving each treatment. In patients who initially received EM, we estimated the time until first treatment. Results: In 3,241 FL patients, the most common initial treatment strategy was CTX alone (n=1,351, 42%), followed by EM (n=1,242, 38%), RT alone (n=434, 13%) and combined CTX+RT (n=214, 7%). Treatment varied widely by age ( Table ). In multivariable analysis, predictors of EM included older age at diagnosis (p&lt;0.0001), greater comorbidity (p&lt;0.001) and earlier stage of disease (p&lt;0.01). Use of CTX and RT, each alone or in combination, decreased with increasing age (p&lt;0.0001 for any CTX, p&lt;0.05 for any RT). Later disease stage was positively associated with CTX (p&lt;0.0001) and negatively associated with RT (p&lt;0.0001). Over time, use of CTX increased (p&lt;0.05) and use of RT decreased (p&lt;0.05). About 70% of EM patients remained treatment-free at two years, and the median time until first treatment for this group was 50 months. Conclusions: A substantial fraction of FL patients over age 65 do not receive any cancer-specific treatment at diagnosis, and most of those patients will remain untreated for more than four years. The potential benefits of earlier or more aggressive treatment of these patients remain to be demonstrated. [Table: see text] [Table: see text]
Abstract 14438: Sensitivity of Cardiac Magnetic Resonance in Biopsy-Proven Acute Myocarditis Varies with Clinical Presentation and Necrotic vs Apoptotic Cell Death
Authors: Cristina Chimenti, Marco Francone, Fernanda Scopelliti, Romina Verardo, Giuseppe Cannavale, Roberto Galea, Francesca Toscano, Andrea Frustaci
Journal: Circulation (2012)

Introduction: Variation of CMR sensitivity in acute myocarditis is still unclear. Hypothesis: We assessed the hypothesis that type of cell death might contribute to clinical presentation and sensitivity of CMR. Methods: We retrospectively evaluated 57 consecutive pts with histological diagnosis of acute myocarditis (≤ 3 months). Combination of T2-weighted (edema), T1-weighted (hyperemia) and late gadolinium enhancement sequences were assessed. Presence of ≥ 2 criteria denoted myocarditis. Apoptosis and necrosis were assessed by in situ ligation of hairpin probes. Results: Three types of clinical pattern of myocarditis were recognized: 1) Infarct-like pattern, with fever, chest pain, ST segment deflection at ECG and serum Troponin I elevation (n=21, 13 M, mean age 44.7±15.3) (panel A) 2) Cardiomyopathy pattern, with isolated left ventricular dysfunction (n=21, 18 M, mean age 52.5±16.2) 3) Arrhythmic pattern, with isolated cardiac arrhythmias (n=15, 10M, 52.6±9.0). Tissue edema was observed in 81% of pts wi...
Oregon’s Medicaid Coordinated Care Organizations
Authors: K. John McConnell
Journal: JAMA (2016)

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Usefulness of SD-101 for screening of sleep apnea syndrome
Authors: Nobuko Hazeki, Kazuyuki Kobayashi, Yumiko Ishikawa, Akane Morimoto, Yoshihiro Nishimura
Journal: European Respiratory Journal (2012)

Objective:  The SD-101 is a sheet-like device for screening of sleep apnea syndrome (SAS). It examines sleep disordered breathing by sensing the alterations of body loading corresponding to respiratory movement. Polysomnography (PSG) is the essential monitor for the diagnosis of SAS. However, PSG is not suitable for screening device for all people suspected of SAS. A simple and easy device is needed for screening of many SAS patients. For evaluation of the usefulness of SD-101 in more detail, the accurateness of SD-101 was examined about detection of hypopnea and apnea.  Subjects and Methods:  Forty four hospitalized patients were enrolled (aged 61.0±13.8, 37 males, Body mass index (BMI) 26.0±4.69kg/m 2 ). They were examined by both PSG and SD-101. They were classified into two group, hypopnea group (Group H, 17 patients) and apnea group (Group A, 27 patients). Group H had hypopnea index accounted for more than 50% of Apnea Hypopnea Index (AHI). Group A had apnea index accounted for more than 50% and equal of AHI. We evaluated correlation between AHI of PSG with respiratory disturbance index (RDI) of SD-101 in each group.  Result:  RDI of SD-101 had very close correlation with AHI of PSG (r 0.886 p Conclusion:  RDI of SD-101 has very close correlation with AHI of PSG, however SD-101 may not detect hypopnea exactly in hypopnea predominant patients.
Inhaled corticosteroids in patients with mild to moderate COPD with and without airway hyperresponsiveness to mannitol: A randomized placebo controlled trial
Authors: Andreas Scherr, Jochmann Anja, Schaffroth Salome, David Miedinger, Maier Sabrina, Anne Taegtmeyer, Chajed Prashant, Sandra Anderson, Tamm Michael, Jörg Daniel Leuppi
Journal: European Respiratory Journal (2011)

Background: Based on former data airway hyperresponsiveness (AHR) to mannitol challenge could allow to identify a subgroup of subjects who will respond to treatment with ICS.

Methods: We investigated 68 subjects with mild to moderately severe COPD. All subjects were treated with tiotropium initiated 4 weeks prior to randomisation. Subjects were randomized to either budesonide (daily dose of 1600 mcg) or placebo for 3 months. At all visits lung function, quality of Life (SGRQ), AHR to mannitol, exhaled nitric oxide (NO) and MRC were assessed. AHR was defined as a 15% fall in FEV1 at < or = 635 mg (PD15). RDR was calculated as the percent fall in FEV1 at the last dose divided by totally dose of mannitol administered.

Results: There was no significant change from baseline of FEV1% pred. (2.46 95% CI [-1; 5.9] p= 0.162), quality of life (SGRQ) (-3.21 95% CI [-8.5; 2.1] p= 0.227), nitric oxide (-5.48 95% CI [-11.2; 0.2] p=0.058) and MRC (0.4 95% CI [0.1; 1.7] p= 0.22) after budesonid treatment. AHR to mannitol was present in 56% of subjects. Steroid treated subjects with AHR showed a significant improvement in quality of life (SGRQ) (8.64 95% CI [1.17; 16.11] p= 0.024), which was not observed in absence of AHR. Concomitantly AHR responded to steroid treatment showing a significant decline in log10 RDR as compared to placebo (0.27 95% CI [-0.04; 0.58] p= 0.09). Our findings were independent from smoking status.

Conclusion: AHR to mannitol improves and seems to result in a better quality of life after ICS treatment in mild to moderate COPD.
Abstract P296: Joint Impact of 61 Genetic Variants in Seven Nicotinic Acetylcholine Receptor Genes on Subclinical Atherosclerosis in American Indians: A Pathway-based Analysis
Authors: Jingyun Yang, Shelley A Cole, Karin Haack, Ying Zhang, Barbara V Howard, Lyle G Best, Mary J Roman, Richard B Devereux, Elisa T Lee, Jinying Zhao
Journal: Circulation (2012)

Background: Atherosclerosis is a complex disease resulting from the joint effects of multiple genetic variants. Cigarette smoking is a strong risk factor for atherosclerotic cardiovascular disease (CVD). Nicotine, the major active component of cigarette smoke, influences CVD by binding to nicotinic acetylcholine receptors (nAChRs). Genetic variants in nAChRs may therefore contribute to atherosclerosis. While each single variant may have only a minor effect, the joint contribution of multiple SNPs to atherosclerosis may be larger. Objective: To investigate the joint impact of 61 SNPs in seven nAChRs genes on subclinical atherosclerosis using a pathway-based approach. Methods: We genotyped 61 tagSNPs in seven nAChRs genes (CHRNA3-A6, CHRNB2-B4) in 3,665 American Indians recruited by the Strong Heart Family Study from Oklahoma (OK), Arizona (AZ) and North/ South Dakota (DK). Subclinical atherosclerosis was assessed by carotid intima-media thickness (cIMT) and carotid plaque score using ultrasound. We performed a pathway-based analysis to evaluate the joint impact of these 61 SNPs on cIMT and plaque score, separately, adjusting for classical cardiovascular risk factors including age, sex, body mass index (BMI), cigarette smoking status (current, former vs. never), alcohol intake (current, former vs. never), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), blood pressure, diabetes, levels of physical activity, fibrinogen, and renal function (assessed by estimated glomerular filtration rate). To avoid population substructure, all statistical analyses were stratified by study center (OK, AZ, and DK). Multiple testing was adjusted using Bonferroni correction. Results: Prevalence of smokers (current plus former) was highest in participants from DK (66%), followed by OK (58%) and AZ (51%). Compared to never smokers, smokers had significantly larger cIMT (0.647mm vs. 0.681mm, P&lt;0.0001) and plaque score (0.568 vs. 0.793, P&lt;0.0001). Among the 61 SNPs examined, only seven SNPs showed significant individual association with cIMT or plaque score in OK after Bonferroni correction. However, a pathway analysis indicates that the nAChRs pathway as a whole in consideration of the joint effects of all 61 SNPs was significantly associated with both cIMT and plaque score in participants from OK and AZ (all p’s&lt;0.001), but not DK. Conclusion: Genetic variants in the nAChRs pathway jointly contribute to subclinical atherosclerosis in American Indians. Though the mechanism linking the nAChRs genetic pathway to subclinical atherosclerosis is unclear, our results may provide valuable information for behavioral and/or molecular strategies for reducing cardiovascular risk in American Indians.
Determinants of maximal inspiratory force and handgrip in a population of healthy elderly subjects
Authors: Frédéric Costes, Sébastien Celle, Martin Garet, Michel Kossovsky, Jean Claude Barthélémy, Frédéric Roche
Journal: European Respiratory Journal (2014)

Peripheral muscle strength decreases with aging, affecting up to 50% of >80 years old subjects. The relationship between muscle depletion and a reduced respiratory strength has not been extensively studied. From a cohort of healthy old subjects (the Proof cohort), we compared the determinants of a reduced maximal inspiratory pressure (MIP) and those of a reduced handgrip (HG) as an index of whole body muscle force.  We measured MIP, and HG of the dominant arm, in 393 healthy subjects aged 72±1 years old. Body composition (biphotonic absorptiometry) and daily energy expenditure (24h_DEE) questionnaire were determined 3 years before. Fat free mass (FFM) was calculated for whole body and for the trunk and was indexed to height (FFMI).  Mean MIP was 77±26 % of predicted value and 90 subjects had a MIP value below normal. Mean HG was 106±19% of predicted value and was reduced below normal in 30 subjects.  We found only a weak correlation between MIP%pred and HG%pred (r=0.175, P  FFMI, the percentage of FFM of the trunk, and 24h_DEE were the only significant covariates which influenced the reduction of MIP. HG reduction was determined by sex, body FFM and 24hDEE.  We conclude that the determinants of a reduction of MIP in elderly differed from those of the HG force, suggesting a differential regulation of respiratory muscle force.
Prevalence of sensitization to ‘improver’ enzymes in UK supermarket bakers
Authors: M. Jones, J. Welch, J Turvey, J. Cannon, P. Clark, J. Szram, P. Cullinan
Journal: Allergy (2016)

Supermarket bakers are exposed not only to flour and alpha-amylase but also to other 'improver' enzymes, the nature of which is usually shrouded by commercial sensitivity. We aimed to determine the prevalence of sensitization to 'improver' enzymes in UK supermarket bakers.We examined the prevalence of sensitization to enzymes in 300 bakers, employed by one of two large supermarket bakeries, who had declared work-related respiratory symptoms during routine health surveillance. Sensitization was determined using radioallergosorbent assay to eight individual enzymes contained in the specific 'improver' mix used by each supermarket.The prevalence of sensitization to 'improver' enzymes ranged from 5% to 15%. Sensitization was far more likely if the baker was sensitized also to either flour or alpha-amylase. The prevalence of sensitization to an 'improver' enzyme did not appear to be related to the concentration of that enzyme in the mix.We report substantial rates of sensitization to enzymes other than alpha-amylase in UK supermarket bakers; in only a small proportion of bakers was there evidence of sensitization to 'improver mix' enzymes without sensitization to either alpha-amylase or flour. The clinical significance of these findings needs further investigation, but our findings indicate that specific sensitization in symptomatic bakers may not be identified without consideration of a wide range of workplace antigens.
Effects of Adenosine and Alpha 1 – Adrenergic blockers on the No-reflow phenomenon.
Authors: L. Gregorini, J. Marco, B. Farrah, Carlo Palombo, I. M. Bossi, M. Kozàkovà, M. Bernies, F. Donatelli, I. Marco, A. Grossi
Journal: Journal of the American College of Cardiology (2001)
춘계학술대회 : 포스터전시 ; 간경변증의 진단에 초음파로 측정된 여러 가지 객관적 지표의 유용성
Authors: 노지훈, 임대관, 윤병철, 한병훈, 이상욱
Journal: Clinical and Molecular Hepatology (2005)

목적: 초음파 검사는 만성 간질환의 선별검사 및 경과관찰에 있어서 널리 사용되고 있으나, 간경변증으로 진행여부에 대한 판단은 비장의 크기 외에 간실질의 에코상, 간표면의 결절상 등 시술자의 숙련도나 경험 등 여러 인자에 의해서 진단의 정확도가 영향을 받는다. 이에 본 연구에서는 복부 초음파로 간경화증을 진단하기 위해 여러가지 객관적 지표를 검사하고자 하였다. 대상 및 방법: 2004년 3월부터 2005년 3월까지 만성간염군(만성 B형 또는 C형 간염 4
Intrasplenic Tumor Formation in the Syrian Hamster ( Mesocricetus auratus ) After Tracheal Implants and Treatment With Diethylnitrosamine
Authors: Ulrich Mohr, Gerd Reznik, Eberhard Emminger
Journal: JNCI Journal of the National Cancer Institute (1976)

In two simultaneous experiments (A and B), tracheal tissue from 25 young Syrian hamsters was implanted in their mothers' spleens. In A, after tracheas from 3-week-old untreated donor offspring were implanted into their mothers, the mothers received 18 mg diethylnitrosamine (DEN)/kg body weight, sc, twice weekly for 20 weeks. Thereafter, the implants were removed and transferred to the spleens of other untreated offspring that were then similarly treated with DEN for 20 weeks. In B, the procedure was similar except that the donor offspring were pretreated with DEN for 20 weeks, beginning at the age of 8 weeks. The average treatment time for the implants in experiment A was 65 weeks; in B, 44 weeks. In A, only four implants demonstrated a papilloma or a papillary polyp. In B, such neoplasms developed after a much shorter treatment time, and in three cases, squamous cell carcinomas with invasive growth in to the splenic pulp were formed.
Interpretation of nonsignificant results.
Authors: J Shuster
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.8.1370 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1634931 Interpretation of nonsignificant results. J ShusterxJ ShusterSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.8.1370 PDF "Interpretation of nonsignificant results.." Journal of Clinical Oncology, 10(8), pp. 1370–1371© 1992 by American Society of Clinical Oncology
Psychiatric Disorders Impeding Weight Loss in Obese Breast Cancer Survivors
Authors: William Hryniuk, Isabella Jenkins, Zora Djuric
Journal: Journal of Clinical Oncology (2016)

TO THE EDITOR: A recently reported, large randomized trial, Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY), used exercise and dietary counseling to reduce the weight of overweight and obese breast cancer survivors, with limited but significant results. Although individuals with “serious medical or psychological conditions” were excluded (14% of those initially screened), it is not clear what screening methods were used or the type of mental disorders that were excluded. In a small randomized trial (n5 48), we tested telecounseling as one component of a strategy to reduce weight in obese breast cancer survivors. Even though we excluded patients with bipolar disorder and schizophrenia, we found that, upon careful psychiatric screening, 49% of subjects participating in the trial had either major depression (23%) or minor psychiatric disorders (26%), according to Diagnostic and Statistical Manual of Mental Disorders IV criteria. A similar overall prevalence of mental disorders (41.6%) has been noted among patients with breast cancer in a recent, more comprehensive study. In our trial, participants with psychiatric disorders lost less weight, lost it more slowly, and regained virtually all of it despite continued intervention compared with those without psychiatric disorders. The finding was statistically (P 5 .019) and clinically significant. The weight loss at 30 months was as follows: 7.8% in participants with no disorder, 3.7% in those with a minor disorder, and 0.7% in those with a major depressive disorder. Despite the limited study size, these differences suggest that, among obese breast cancer survivors, there is a strong relationship between weight loss success and psychological well-being. This suggests future attempts at inducing weight loss in obese breast cancer survivors should take into account the mental health of study subjects, especially when evaluating results. The ENERGY trial may have included a substantial proportion of subjects with unrecognized psychiatric disorders, thus lowering the degree of weight loss attained. Assessment of the mental health of obese subjects in that trial, if feasible, might represent an opportunity to confirm our findings and give added impetus to the field.
Maternal-Age and Birth-Order Effects in Childhood Leukemia: Age of Child and Type of Leukemia
Authors: Charles R. Stark, Nathan Mantel
Journal: JNCI Journal of the National Cancer Institute (1969)

Year of life in which leukemia death occurred and leukemia cell type were controlled in studies of maternal-age and birth-order effects on risk of leukemia mortality in Michigan children during 1950–64. The birth-order effect was strongest for leukemia deaths in the 3d through 10th years of life, and the maternal-age effect was strongest in the 4th through 8th years of life. Little, if any, association between these birth characteristics and risk of childhood myelocytic leukemia was found. These results suggest that the birth-order and maternal-age effects are limited to children dying of nonmyelocytic leukemia during the years of peak mortality risk. The findings also provide an additional basis for differentiating the two broad cellular categories of childhood leukemia.