tbuckley/cabot-search huggingface dataset:
Post-transplant plasmablastic lymphoma of the skin
Authors: I. Nicol, T. Boye, F. Carsuzaa, L. Feier, A.M. Collet Villette, L. Xerri, J.J. Grob, M.A. Richard
Journal: British Journal of Dermatology (2003)

Journal Article Post‐transplant plasmablastic lymphoma of the skin Get access I. Nicol, I. Nicol Service de Dermatologie, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, 13277 Marseille Cedex 9, France Search for other works by this author on: Oxford Academic Google Scholar T. Boye, T. Boye Service de Dermatologie, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, 13277 Marseille Cedex 9, France Search for other works by this author on: Oxford Academic Google Scholar F. Carsuzaa, F. Carsuzaa Service de Dermatologie, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, 13277 Marseille Cedex 9, France Search for other works by this author on: Oxford Academic Google Scholar L. Feier, L. Feier Service de Dermatologie, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, 13277 Marseille Cedex 9, France Search for other works by this author on: Oxford Academic Google Scholar A.M. Collet Villette, A.M. Collet Villette Service de Dermatologie, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, 13277 Marseille Cedex 9, France Search for other works by this author on: Oxford Academic Google Scholar L. Xerri, L. Xerri Service de Dermatologie, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, 13277 Marseille Cedex 9, France Search for other works by this author on: Oxford Academic Google Scholar J.J. Grob, J.J. Grob Service de Dermatologie, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, 13277 Marseille Cedex 9, France Search for other works by this author on: Oxford Academic Google Scholar M.A. Richard M.A. Richard Service de Dermatologie, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, 13277 Marseille Cedex 9, France Marie Aleth Richard, E‐mail: marie‐aleth.richard@mail.ap‐hm.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 4, 1 October 2003, Pages 889–891, https://doi.org/10.1046/j.1365-2133.2003.05544.x Published: 01 October 2003
Lymphoma-type adult T-cell leukaemia-lymphoma with a bulky cutaneous tumour showing multiple human T-lymphotropic virus-1 DNA integration
Authors: N. Kato, H. Sugawara, S. Aoyagi, M. Mayuzumi
Journal: British Journal of Dermatology (2001)

Human T-lymphotropic virus-1 (HTLV-1) is considered to be the cause of adult T-cell leukaemia-lymphoma (ATL). Monoclonal integration of HTLV-1 proviral DNA, as is analysed by Southern blotting, has been demonstrated in ATL patients. Unusual integration patterns of HTLV-1 proviral DNA have occasionally been described, and it is suggested that the patterns have clinical implications for ATL pathophysiology. Multiple, complete and defective types of integration patterns, in that order, are apparently associated with prognoses from good to poor. We report a 73-year-old Japanese woman with lymphoma-type ATL and a bulky cutaneous tumour on the left thigh. Four bands of slightly differing intensity were seen after EcoRI digestion of skin and lymph node samples on Southern blot analysis of HTLV-1 proviral DNA. Analysis for T-cell receptor-β gene revealed five novel bands after restriction enzyme digestion with HindIII, indicating that the patient has four separate tumour cell clones, each of which carries one copy of the provirus. She was treated with chemotherapy and radiation and remains under reasonable control despite some relapsing cutaneous nodules. The indolent course in this present case could be related to the multiple integration pattern of HTLV-1 proviral DNA detected.
High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer
Authors: Sytse J. Piersma, Ekaterina S. Jordanova, Mariëtte I.E. van Poelgeest, Kitty M.C. Kwappenberg, Jeanette M. van der Hulst, Jan W. Drijfhout, Cornelis J.M. Melief, Gemma G. Kenter, Gert Jan Fleuren, Rienk Offringa, Sjoerd H. van der Burg
Journal: Cancer Research (2007)

Abstract In a prospective study, we have examined the tumor-specific immune response in a group of 59 patients with human papillomavirus (HPV) 16-positive (HPV16+)–induced or HPV18+-induced cervical cancer. Local antitumor immunity was analyzed by the enumeration of tumor-infiltrating dendritic cells and CD4+, CD8+, and regulatory T cells as well as by calculation of the ratio of CD8+/CD4+ T cells and CD8+/regulatory T cells. Systemic tumor-specific immunity was assessed by determination of the HPV E6- and/or E7-specific T-cell response in the blood of these patients. Finally, these variables were evaluated with respect to known histopathologic prognostic variables, including the absence (LN−) or presence (LN+) of lymph node metastases. Stratification according to the lymph node status of patients revealed a significantly stronger CD8+ T-cell tumor infiltration, a higher CD8+/CD4+ T-cell ratio, and higher CD8+/regulatory T-cell ratio in the group of patients in which the tumor failed to metastasize to the tumor-draining lymph node. Subdivision according to the presence (IR+) or absence (IR−) of circulating HPV-specific T cells disclosed that the highest number of tumor-infiltrating CD8+ T cells was found in the group of LN− patients displaying a concomitant systemic tumor-specific immune response (LN−IR+). CD8+ T-cell infiltration in LN−IR− patients was comparable with that of LN+ patients. In cervical cancer, the absence of lymph node metastases is strongly associated with a better prognosis. Our data indicate that, especially in a subgroup of LN− patients, a strong and effective interaction between immune system and tumor exists. This subgroup of cervical cancer patients may have the best prognosis. [Cancer Res 2007;67(1):354–61]
X-linked ichthyosis
Authors: P. UNAMUNO, A. Martin-Pascual, A. Garcia-Perez
Journal: British Journal of Dermatology (1977)

In the period 1962–1974, 36 patients with X‐linked ichthyosis, belonging to 22 families, were selected for study. The frequency of this genodermatosis is higher in the province of Salamanca than in other countries. In most of the cases, the lesions were apparent at birth or shortly after. In 41% of the patients studied by slit‐lamp microscopy, posterior embriotoxom was seen. Hyperkeratosis was seen in follicular and sweat duct orifices. Statistical analysis of the pedigrees showed a higher proportion of affected males among the offspring of carriers and also among the offspring of the ichthyotics' sisters. In addition, among the patients' descendants, the higher ratio of females is statistically significant, showing that there is likely to be selection in favour of the X chromosome.
Relation between synovial fluid C3 degradation products and local joint inflammation in rheumatoid arthritis, osteoarthritis, and crystal associated arthropathy.
Authors: M Doherty, N Richards, J Hornby, R Powell
Journal: Annals of the Rheumatic Diseases (1988)

C3 degradation products (C3dg/d) were estimated in 288 synovial fluid (SF) samples (rheumatoid arthritis (RA) 93, osteoarthritis (OA) 68, chronic pyrophosphate arthropathy 80, acute pseudogout 20, others 27) from knees of 138 patients (bilateral 67, serial sampling on two to six occasions 40). At each aspiration knees were defined as 'active' or 'inactive' by single observer global assessment using six clinical parameters of inflammation. Lack of correlation between paired SF and plasma C3dg/d implied local C3 activation within joints. Raised SF C3d levels were found in active compared with inactive RA joints (mean (range) 51 (15-105) and 6 (0-15) units/ml respectively). Low SF C3dg/d levels were found in OA (mean (range) 0.8 (0-7) units/ml) and chronic pyrophosphate arthropathy (mean (range) 4 (0-16) units/ml), irrespective of clinical activity. In contrast, very high levels (mean (range) 61 (16-126) units/ml) were present in all cases of pseudogout. These differences remained after correction for SF C3 or albumin. This study is the first to show a positive correlation between SF C3dg/d and local inflammation in RA joints. It further suggests that C3 activation is a constant feature of pseudogout but not an accompaniment of inflammation associated with chronic crystal associated synovitis or OA.
Overdominance in the Human Genome and Olfactory Receptor Activity
Authors: S. Alonso, S. Lopez, N. Izagirre, C. de la Rua
Journal: Molecular Biology and Evolution (2008)

We investigate the contribution of overdominance to the maintenance of polymorphism in the human genome during the recent evolution of our species. Using the HapMap genotypic information, we have detected that the Gene Ontology term "olfactory receptor activity" is a molecular function overrepresented in genes that have SNPs (Single Nucleotide Polymorphisms) showing higher than expected number of heterozygotes in the HapMap populations. Our results suggest that the diversity of a subset of human olfactory receptors (ORs) may have been maintained by balancing selection, in the form of overdominance. This observation may suggest that the loss of OR genes during the evolution of the human lineage may have been accompanied by an increased capability to discriminate odorants with closely similar structures.
Capillary leak syndrome induced by acitretin
Authors: J.L. Estival, M. Dupin, J. Kanitakis, P. Combemale
Journal: British Journal of Dermatology (2004)

Journal Article Capillary leak syndrome induced by acitretin Get access J.L. Estival, J.L. Estival Department of Dermatology, Desgenettes Military Hospital, 108 Bd Pinel, 69275 Lyon cedex 3, France *Department of Dermatology (Pav. R), Ed. Herriot Hospital, 69437 Lyon cedex 3, France Search for other works by this author on: Oxford Academic Google Scholar M. Dupin, M. Dupin Department of Dermatology, Desgenettes Military Hospital, 108 Bd Pinel, 69275 Lyon cedex 3, France *Department of Dermatology (Pav. R), Ed. Herriot Hospital, 69437 Lyon cedex 3, France Search for other works by this author on: Oxford Academic Google Scholar J. Kanitakis, J. Kanitakis Department of Dermatology, Desgenettes Military Hospital, 108 Bd Pinel, 69275 Lyon cedex 3, France *Department of Dermatology (Pav. R), Ed. Herriot Hospital, 69437 Lyon cedex 3, France Search for other works by this author on: Oxford Academic Google Scholar P. Combemale P. Combemale Department of Dermatology, Desgenettes Military Hospital, 108 Bd Pinel, 69275 Lyon cedex 3, France *Department of Dermatology (Pav. R), Ed. Herriot Hospital, 69437 Lyon cedex 3, France Patrick Combemale. E‐mail: pcombemale@reseaunances.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 1, 1 January 2004, Pages 150–152, https://doi.org/10.1111/j.1365-2133.2004.05771.x Published: 01 January 2004 Article history Accepted: 10 August 2003 Published: 01 January 2004
STINGING INSECT HYPERSENSITIVITY: A PRACTICE PARAMETER
Authors: Jay M. Portnoy, John E. Moffitt, David B.K. Golden, I.Leonard Bernstein, William E. Berger, Mark S. Dykewicz, Stanley M. Fineman, Rufus E. Lee, James T. Li, Richard A. Nicklas, Diane E. Schuller, Sheldon L. Spector
Journal: Journal of Allergy and Clinical Immunology (1999)
Intention to treat analysis versus per protocol analysis of trial data
Authors: P. Sedgwick
Journal: BMJ (2015)

Researchers evaluated the effectiveness of a self management programme for arthritis on the overall function of patients with osteoarthritis in primary care. A randomised controlled trial study design was used. The intervention was attendance at six sessions of self management of arthritis, plus an education booklet. The control group received the education booklet only. Participants were patients aged 50 years or more who had osteoarthritis of the hips or knees (or both) and pain or disability (or both). In total, 812 patients were recruited and randomised to the intervention (n=406) or control (n=406).1

The primary outcome was quality of life, as assessed by the short form health survey (SF-36). Secondary outcomes included physical and psychosocial measures. Outcome measures were recorded by postal questionnaires, collected at baseline and 12 months. Analysis was performed on an intention to treat approach. The researchers reported that the intervention group showed a significant reduction on the anxiety subscore of the hospital anxiety and depression scale at 12 months (mean difference 0.62, 95% confidence interval 0.16 to 1.08). The intervention group also showed a significant improvement on the arthritis self efficacy scale for pain (0.98, 0.07 to 1.89) and self efficacy for other aspects of management (1.58, 0.25 to 2.90). Per protocol analysis produced similar results to the intention to treat analysis with respect to significant findings. It was concluded that the self management of arthritis programme reduced anxiety and improved participants’ perceived self efficacy to manage symptoms, although it had no significant effect on pain, physical functioning, or …
Disease severity in children and adolescents with familial Mediterranean fever: a comparative study to explore environmental effects on a monogenic disease
Authors: S Ozen, N Aktay, E Lainka, A Duzova, A Bakkaloglu, T Kallinich
Journal: Annals of the Rheumatic Diseases (2008)

Background: Worldwide, familial Mediterranean fever (FMF) is the most common autoinflammatory disease. It has been suggested that environmental factors affect the phenotype as some patients do not develop the complication of secondary amyloidosis. Objective: To analyse whether disease severity in Turkish children with FMF, living in Turkey and Germany is different. Patients and methods: A total of 55 Turkish children living in Turkey were compared with 45 Turkish children born and raised in Germany. Mean age among the group from Turkey and Germany was 42.2 and 44.29 months, respectively. M694V was the leading mutation in both groups. The severity scores were compared with two scoring systems, modified according to published paediatric data for dosage. Results: There was no significant difference between the mean C-reactive protein and erythrocyte sedimentation rate levels of the two groups. According to the modified Sheba Center score, 78.2% of patients from the group living in Turkey had a severe course compared with 34.1% from the group living in Germany. The modified score of Pras et al also showed more severe disease in the patients from Turkey. The difference between the two groups for both scoring systems were significant (both p&lt;0.05). Conclusions: We believe the modified scores that we introduce can be widely used for children. Our results suggest that the environment affects the phenotype of a monogenic disease of the innate inflammatory pathway.
Beyond mechanism and constructivism
Authors: Boris Kotchoubey
Journal: Behavioral and Brain Sciences (2008)

Abstract Neuroconstructivism is a hybrid of two incompatible philosophical traditions: a radical idealism insisting upon the free activity of the Subject; and a radical materialistic anthropomorphism, which ascribes inherent properties of humans (e.g., the ability to construct) to nonhuman objects or body parts (e.g., the brain). The two traditions can be combined only by obscuring or confusing the basic notions.
Dysregulation of in vitro cytokine production by monocytes during sepsis.
Authors: C Munoz, J Carlet, C Fitting, B Misset, J P Blériot, J M Cavaillon
Journal: Journal of Clinical Investigation (1991)

The production by monocytes of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF alpha) in intensive care unit (ICU) patients with sepsis syndrome (n = 23) or noninfectious shock (n = 6) is reported. Plasma cytokines, cell-associated cytokines within freshly isolated monocytes and LPS-induced in vitro cytokine production were assessed at admission and at regular intervals during ICU stay. TNF alpha and IL-6 were the most frequently detected circulating cytokines. Despite the fact that IL-1 alpha is the main cytokine found within monocytes upon in vitro activation of cells from healthy individuals, it was very rarely detected within freshly isolated monocytes from septic patients, and levels of cell-associated IL-1 beta were lower than those of TNF alpha. Cell-associated IL-1 beta and TNF alpha were not correlated with corresponding levels in plasma. Upon LPS stimulation, we observed a profound decrease of in vitro IL-1 alpha production by monocytes in all patients, and of IL-1 beta, IL-6, and TNF alpha in septic patients. This reduced LPS-induced production of cytokines was most pronounced in patients with gram-negative infections. Finally, monocytes from survival patients, but not from nonsurvival ones recovered their capacity to produce normal amounts of cytokines upon LPS stimulation. In conclusion, our data indicate an in vivo activation of circulating monocytes during sepsis as well as in noninfectious shock and suggest that complex regulatory mechanisms can downregulate the production of cytokines by monocytes during severe infections.
Earlier versus Later Start of Antiretroviral Therapy in HIV-Infected Adults with Tuberculosis
Authors: François-Xavier Blanc, Thim Sok, Didier Laureillard, Laurence Borand, Claire Rekacewicz, Eric Nerrienet, Yoann Madec, Olivier Marcy, Sarin Chan, Narom Prak, Chindamony Kim, Khemarin Kim Lak, Chanroeurn Hak, Bunnet Dim, Chhun Im Sin, Sath Sun, Bertrand Guillard, Borann Sar, Sirenda Vong, Marcelo Fernandez, Lawrence Fox, Jean-François Delfraissy, Anne E. Goldfeld
Journal: New England Journal of Medicine (2011)

Tuberculosis remains an important cause of death among patients infected with the human immunodeficiency virus (HIV). Robust data are lacking with regard to the timing for the initiation of antiretroviral therapy (ART) in relation to the start of antituberculosis therapy.We tested the hypothesis that the timing of ART initiation would significantly affect mortality among adults not previously exposed to antiretroviral drugs who had newly diagnosed tuberculosis and CD4+ T-cell counts of 200 per cubic millimeter or lower. After beginning the standard, 6-month treatment for tuberculosis, patients were randomly assigned to either earlier treatment (2 weeks after beginning tuberculosis treatment) or later treatment (8 weeks after) with stavudine, lamivudine, and efavirenz. The primary end point was survival.A total of 661 patients were enrolled and were followed for a median of 25 months. The median CD4+ T-cell count was 25 per cubic millimeter, and the median viral load was 5.64 log(10) copies per milliliter. The risk of death was significantly reduced in the group that received ART earlier, with 59 deaths among 332 patients (18%), as compared with 90 deaths among 329 patients (27%) in the later-ART group (hazard ratio, 0.62; 95% confidence interval [CI]; 0.44 to 0.86; P=0.006). The risk of tuberculosis-associated immune reconstitution inflammatory syndrome was significantly increased in the earlier-ART group (hazard ratio, 2.51; 95% CI, 1.78 to 3.59; P<0.001). Irrespective of the study group, the median gain in the CD4+ T-cell count was 114 per cubic millimeter, and the viral load was undetectable at week 50 in 96.5% of the patients.Initiating ART 2 weeks after the start of tuberculosis treatment significantly improved survival among HIV-infected adults with CD4+ T-cell counts of 200 per cubic millimeter or lower. (Funded by the French National Agency for Research on AIDS and Viral Hepatitis and the National Institutes of Health; CAMELIA ClinicalTrials.gov number, NCT01300481.).
Toll-like Receptor 8 (TLR8)-Mediated Inhibition of Th2 Cytokine Responses to Ragweed Antigen in Peripheral Blood Mononuclear Cells (PBMC) of Ragweed Allergic Individuals
Authors: J LAWSON, B YU, L THOMAS, A LANDAY, J MOY
Journal: Journal of Allergy and Clinical Immunology (2008)
The Psychosocial Treatment of Schizophrenia: An Update
Authors: J Bustillo, J Lauriello, W Horan, S Keith
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: The authors sought to update the randomized controlled trial literature of psychosocial treatments for schizophrenia. METHOD: Computerized literature searches were conducted to identify randomized controlled trials of various psychosocial interventions, with emphasis on studies published since a previous review of psychosocial treatments for schizophrenia in 1996. RESULTS: Family therapy and assertive community treatment have clear effects on the prevention of psychotic relapse and rehospitalization. However, these treatments have no consistent effects on other outcome measures (e.g., pervasive positive and negative symptoms, overall social functioning, and ability to obtain competitive employment). Social skills training improves social skills but has no clear effects on relapse prevention, psychopathology, or employment status. Supportive employment programs that use the place-and-train vocational model have important effects on obtaining competitive employment. Some studies have shown improvements in delusions and hallucinations following cognitive behavior therapy. Preliminary research indicates that personal therapy may improve social functioning. CONCLUSIONS: Relatively simple, long-term psychoeducational family therapy should be available to the majority of persons suffering from schizophrenia. Assertive community training programs ought to be offered to patients with frequent relapses and hospitalizations, especially if they have limited family support. Patients with schizophrenia can clearly improve their social competence with social skills training, which may translate into a more adaptive functioning in the community. For patients interested in working, rapid placement with ongoing support offers the best opportunity for maintaining a regular job in the community. Cognitive behavior therapy may benefit the large number of patients who continue to experience disabling psychotic symptoms despite optimal pharmacological treatment.
Apoptosis Signal-Regulating Kinase 1–Mediated Signaling Pathway Regulates Nitric Oxide–Induced Activator Protein-1 Activation in Human Bronchial Epithelial Cells
Authors: Itsuro Jibiki, Shu Hashimoto, Shuichiro Maruoka, Yasuhiro Gon, Atsushi Matsuzawa, Hideki Nishitoh, Hidenori Ichijo, Takashi Horie
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Exhaled nitric oxide (NO) is increased in individuals with bronchial asthma. NO may have antiinflammatory and proinflammatory effects; however, its role in bronchial asthma is unclear. In the present study, to clarify this issue we examined the effect of NO in inducing activator protein-1 (AP-1) activation in human bronchial epithelial cells (BEC) and a role of apoptosis signal-regulating kinase1 (ASK1), an upstream kinase kinase of c-Jun-NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in NO-mediated AP-1 activation. The results showed that (1) the reactive nitrogen generating species NOR-1(+/--(E)-methyl-2-[(E)-hydroxykmino]-5-nitro-6-methoxy-3-hexeneamide]) induced AP-1 activation determined by AP-1-dependent luciferase gene activity, and an NO scavenger, carboxyl-PTIO, attenuated NOR-1-induced AP-1 activation; (2) NOR-1 phosphorylated ASK1, JNK, and p38 MAPK; and (3) transient transfection of the dominant negative form of AKS1 attenuated NOR-1-induced AP-1 activation in BEC. To further characterize the role of ASK-1 cascade, the dominant negative form of ASK1-stable transfected porcine artery endothelial (PAE) cells were used. AP-1 activity and JNK and p38 MAPK phosphorylation were depressed in the dominant-negative form of ASK1-stable transfected PAE cells. These results indicate that NO is capable of inducing AP-1 activation, and that ASK1-p38 MAPK/JNK cascade regulates AP-1 activation in NO-stimulated BEC.