Unidentified Virus-Like Particles in the Intestine of Patients with the Acquired Immunodeficiency Syndrome
Authors: FRANCIS W. CHANDLER
Journal: Annals of Internal Medicine (1984)

Brief Reports1 June 1984Unidentified Virus-Like Particles in the Intestine of Patients with the Acquired Immunodeficiency SyndromeFRANCIS W. CHANDLER, D.V.M., Ph.D., ELIZABETH H. WHITE, M.S., CAREY S. CALLAWAY, B.S., THOMAS J. SPIRA, M.D., EDWIN P. EWING Jr., M.D.FRANCIS W. CHANDLER, D.V.M., Ph.D.Search for more papers by this author, ELIZABETH H. WHITE, M.S.Search for more papers by this author, CAREY S. CALLAWAY, B.S.Search for more papers by this author, THOMAS J. SPIRA, M.D.Search for more papers by this author, EDWIN P. EWING Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-6-851 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the cause of the acquired immunodeficiency syndrome is unknown, epidemiologic evidence shows that this syndrome is transmissible both sexually and parenterally (1). Recent serologic and virologic studies suggest a link between the syndrome and infection with a retrovirus related to the human T-cell leukemia virus (2-4).After electron microscopic studies of lymph nodes from homosexual men with unexplained lymphadenopathy failed to show a virus-like agent (5), we systematically searched for virus-like particles in tissue samples from the intestine, salivary gland, testis, and prostate from patients who had died of the acquired immunodeficiency syndrome. These organs were studied because of...References1. . Acquired immunodeficiency syndrome (AIDS) update—United States. MMWR. 1983;32:309-11. MedlineGoogle Scholar2. ESSEXMCLANELEE MMT. Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS. Science. 1983;220:859-62. CrossrefMedlineGoogle Scholar3. GALLOSARINGELMANN RPE. Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science. 1983;220:865-7. CrossrefMedlineGoogle Scholar4. BARRE-SINOUSSICHERMANNREY FJF. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 1983;220:868-71. CrossrefMedlineGoogle Scholar5. EWINGSPIRACHANDLERCALLAWAYBRYNESCHAN ETFCRW. Unusual cytoplasmic body in lymphoid cells of homosexual men with unexplained lymphadenopathy: a preliminary report. N Engl J Med. 1983;308:819-22. CrossrefMedlineGoogle Scholar6. MOSESGLADEKASELROSENTHALHIRSHAUTCHESSIN HPJAYL. Infectious mononucleosis: detection of herpeslike virus and reticular aggregates of small cytoplasmic particles in continuous lymphoid cell lines derived from peripheral blood. Proc Natl Acad Sci USA. 1968;60:489-96. CrossrefMedlineGoogle Scholar7. FERRANSTHIEDEMANNMARONJONESROBERTS VKBMW. Spherical microparticles in human myocardium: an ultrastructural study. Lab Invest. 1976;35:349-68. MedlineGoogle Scholar8. JORISMAJNO IG. Cellular breakdown within the arterial wall: an ultrastructural study of the coronary artery in young and aging rats. Virchows Arch [Path Anat]. 1974;364:111-27. CrossrefMedlineGoogle Scholar9. DALTON A. Microvesicles and vesicles of multivesicular bodies versus "virus-like" particles. J Natl Cancer Inst. 1975;54:1137-48. CrossrefMedlineGoogle Scholar10. JAFFECHOITHOMAS HKP. National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: Part 1. Epidemiologic results. Ann Intern Med. 1983;99:145-51. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Centers for Disease Control Atlanta, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByQuantitative histological study of enteropathy associated with HIV infection.Viral infections in the acquired immunodeficiency syndromeIntestinal and Hepatic Complications of Human Bone Marrow Transplantation. Part IIEnteropathy Associated with the Acquired Immunodeficiency SyndromeDONALD P. KOTLER, M.D., HAROLD P. GAETZ, M.D., MICHAEL LANGE, M.D., ELENA B. KLEIN, M.D., PETER R. HOLT, M.D. 1 June 1984Volume 100, Issue 6Page: 851-853KeywordsAIDSEpidemiologyHIVHomosexualsInfectious disease controlInfectious diseasesLymph nodesProstate glandRetrovirusesSalivary glands Issue Published: 1 June 1984 PDF DownloadLoading ...