ALLERGIC REACTIONS TO TRANQUILIZING DRUGS
Authors: L E HOLLISTER
Journal: Annals of Internal Medicine (1958)

Article1 July 1958ALLERGIC REACTIONS TO TRANQUILIZING DRUGSLEO E. HOLLISTER, M.D.LEO E. HOLLISTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-1-17 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTranquilizing drugs, like most others, may act as allergens. Three classes of tranquilizing drugs have been widely used and allergic reactions reported from their use. These classes of drugs are: (a) the phenothiazine derivatives, notably chlorpromazine, (b) the Rauwolfia alkaloids, notably reserpine, and (c) the substituted propanediols or butanediols, notably meprobamate. In the case of the first and third classes of drugs, allergic reactions account for the major complications encountered.PHENOTHIAZINE DERIVATIVES (CHLORPROMAZINE, PROMAZINE, TRIFLUPROMAZINE, MEPAZINE, PROCLORPERAZINE, PERPHENAZINE)Agranulocytosis:The most serious complication produced by these drugs is agranulocytosis, although it is fortunately rare. Due to the exceptionally wide use...Bibliography1. Report to the Council on Pharmacy and Chemistry: Blood dyscrasias associated with chlorpromazine therapy, J. A. M. A. 160: 287, 1956. Google Scholar2. RotsteinFrickSchiele JPSBC: Agranulocytosis associated with chlorpromazine therapy, Arch. Int. Med. 96: 781, 1955. CrossrefGoogle Scholar3. Pollack B: Recurrent Thorazine-induced agranulocytosis, Am. J. Psychiat. 113: 557, 1956. CrossrefMedlineGoogle Scholar4. YulesBaker JHH: Agranulocytosis during chlorpromazine therapy, Bull. Tufts New England M. Center 1: 224, 1955. MedlineGoogle Scholar5. 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CrossrefMedlineGoogle Scholar26. MeyerNeeveBertscherm LMWLRW: Aplastic anemia after meprobamate (2-methyl-2-n-propyl-1, 3-propanediol dicarbamate) therapy, New England J. Med. 256: 1232, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Palo Alto, California*Received for publication September 26, 1957.From the Veterans Administration Hospital, Palo Alto, California.Requests for reprints should be addressed to Leo E. Hollister, M. D., Chief, Medical Service, Veterans Administration Hospital, Palo Alto, California. 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