tbuckley/cabot-search huggingface dataset:
Diagnostic value of gamma interferon assay in tuberculosis pericardial effusions: Study on a cohort of Iranian patients
Authors: Soroush Seifirad, Setareh Davoudi, Reihaneh Mohsenipour, Farzad Masoudkabir, Abbas Salehi Omran
Journal: European Respiratory Journal (2012)

BACKGROUND: The efficacy of Interferon-gamma (INF-gamma) and adenosine deaminase (ADA) for diagnosing tuberculosis pericarditis in a cohort of Iranian patients presenting with pericarditis were evaluated. METHODS: Thirty eight patients with presentation of pericarditis underwent diagnostic and therapeutic pericardiostomy with drainage and biopsy. Adenosine deaminase and Interferon-gamma levels were determined in pericardial fluid samples of all patients. Pericardial tissue samples were submitted for histopathologic and microbiologic studies. Polymerase chain reaction (PCR) was performed on all pericardial fluid samples to detect Mycobacterium tuberculosis. RESULTS: Among 38 patients with pericarditis, 7 cases were diagnosed as tuberculosis pericarditis (18.4%). Mean concentration of Interferon-gamma in tuberculosis group was significantly higher compared to non-tuberculosis group (69257.14±43427.8 vs. 329.03±433.7, P
Clinical outcomes of spinal cord stimulation (SCS) to restore cough
Authors: Anthony DiMarco, Krzysztof Kowalski, Robert Geertman, Dana Hromyak, Frederick Frost, Gregory Nemunaitis
Journal: European Respiratory Journal (2011)

Background:  In spinal cord injury (SCI), paralysis of the expiratory muscles often results in an ineffective cough and consequent inability to effectively clear airway secretions. SCS is an effective method of expiratory muscle activation.   Design:  Clinical trial assessing the clinical outcomes and side effects of SCS to restore an effective cough in 12 SCI subjects.   Main outcome measure(s):  Ease in raising secretions, requirement for trained caregiver support for secretion management and incidence of acute respiratory tract infections.   Results:  Based upon questionnaire responses, the degree of difficulty in raising secretions improved markedly, and the need for alternative methods of secretion removal was virtually eliminated in each subject. Requirement of trained caregiver support over a 2 week period decreased from 18.0±6.8 (baseline) to 3.4±2.0 and 2.6±2.3 and 2.8±2.5 times/week (p   Conclusion(s):  Restoration of cough via SCS significantly reduces the difficulty in raising secretions, need for caregiver support and incidence of respiratory tract infection. Moreover, this method improves life quality and has the potential to reduce the morbidity and mortality associated with respiratory tract infections in SCI.  Support: NIH: R01NS049516, RC1NS068576, M01RR0080 & UL1RR024989.   Disclosure:  Dr. DiMarco is a Founder of and has a significant financial interest in Synapse BioMedical, Inc, a manufacturer of diaphragm pacing systems.
A phase I study of the humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) TheraCIM-h-R3 (nimotuzumab) in patients with advanced solid tumors
Authors: A. M. Brade, L. Siu, A. M. Oza, B. Southwood, M. De Borja, G. R. Pond, I. A. Sherman, E. Chen
Journal: Journal of Clinical Oncology (2006)

13054 Background: Nimotuzumab is a humanized mAb against the extracellular ligand binding domain of EGFR. Although well tolerated when combined with radiotherapy in previous studies, the pharmacodynamics (PD) of nimotuzumab has not been elucidated. This phase I study was designed to evaluate the safety, tolerability and PD of nimotuzumab. Methods: Eligibility criteria included advanced solid tumors refractory to standard therapy and performance status of ECOG 0–2. Nimotuzumab was administered intravenously weekly × 6 and then every other week (6 weeks = 1 treatment cycle). Tumor and skin biopsies were obtained at baseline and after 2 weeks of treatment. Results: To date, 9 patients (7 m/2 f, median age 60, 7 colorectal cancer, ECOG 0:1:2 = 5:3:1, prior therapy 1:2:3+ = 1:3:5) have been treated on the first 2 dose levels (100 mg and 200 mg) for a total of 13 treatment cycles. The most common toxicities, mainly grade 1- 2, were lymphopenia (n = 8 patients), fatigue (n = 8), abnormal liver function tests (n = 7) and anemia (n = 6). Observed grade 3 toxicities include: pain (n = 3), hyponatremia (n = 2), elevated ALP (n = 2), fatigue (n = 1), hyperglycemia (n = 1) and hyperkalemia (n = 1). One patient at the first dose level experienced grade 3 fatigue, at least possibly attributable to nimotuzumab, and thus considered as a dose-limiting toxicity (DLT). No DLT were observed in the expanded cohort and dose level 2. No skin toxicities were observed. Stable disease was seen in 3 patients with colorectal cancer. PD from tumor and skin biopsies will be presented, and may clarify the reason for the lack of skin toxicity. Conclusions: Overall nimotuzumab was well tolerated, with disease stabilization observed in heavily pretreated patients. Accrual continues at dose level 3 (400 mg) with one further planned dose level (800 mg). [Table: see text]
Abstract 15083: Precise Etiology of Death within 30 days of Percutaneous Coronary Intervention in an era of Mandatory Outcome Reporting
Authors: Bhuvnesh Aggarwal, Stephen G Ellis, Michael A Lincoff, Samir R Kapadia, Joseph Cacchione, Russell E Raymond, Leslie Cho, Christopher Bajzer, Ravi Nair, Irving Franco, Conrad Simpfendorfer, E M Tuzcu, Patrick L Whitlow, Mehdi H Shishehbor
Journal: Circulation (2012)

Objectives: To ascertain the precise causes of death and the prevalence of percutaneous coronary intervention (PCI) related mortality within 30 days of PCI. Background: Public reporting of 30-day p...
Short-term weekly chemotherapy followed by high-dose therapy with autologous bone marrow transplantation for lymphoblastic and Burkitt’s lymphomas in adult patients
Authors: L.M. Jost, E. Jacky, C. Dommann-Scherrer, H.-P. Honegger, R. Maurer, C. Sauter, R.A. Stahel
Journal: Annals of Oncology (1995)
Nuclear factor-kB (NF-kB) predicts outcome in locally advanced rectal cancer patients receiving radio-chemotherapy
Authors: R. Berardi, A. Mandolesi, I. Bearzi, M. Scartozzi, G. Mantello, A. Onofri, C. Pierantoni, C. Marmorale, A. Fianchini, S. Cascinu
Journal: Journal of Clinical Oncology (2008)

22122 Background: NF-kB expression has been shown to be responsible for resistance to antineoplastic agents. The aim of our analysis was to investigate the importance of NF-kB expression, as prognostic factor in patients with locally advanced rectal cancer patients receiving receiving neoadjuvant radiochemotherapy. Methods: We analyzed the immunoreactivity for NF-kB in patients with locally advanced rectal cancer who underwent neoadjuvant treatment (chemotherapy and radiotherapy) to our institution between January 2003 and June 2005. Results: Fifty-three patients were eligible for our analysis. Median age at diagnosis was 62 years (range 37–80). Male/female ratio was 32/21. All the patients received radiotherapy plus 5-fuorouracil/capecitabile-based chemotherapy. NF-kB assessed prior to neoadjuvant treatment was positive in 33 patients (62.3%). All main clinical characteristics were well balanced between NF-kB-positive and NF-kB-negative patients. Time to progression (TTP) and survival were significantly longer in NF-kB-negative patients (p=0.03), median TTP and median survival have not been reached in the two groups, yet. Interestingly, all the 10 patients (18.9%) who achieved a complete pathological response were NF-kB negative in the baseline biopsy. Conclusion: Our results suggest that NF-kB, could represent an important parameter able to predict the outcome in patients receiving neoadjuvant treatment for rectal cancer. It also could be useful in order to select patients to receive adjuvant chemotherapy after neoadjuvant treatment and surgery for locally advanced rectal cancer, intensifying the adjuvant therapy and obviating the use of the drugs involving NF-kB in their mechanism of action in NF-kB-positive patients. No significant financial relationships to disclose.
Abstract B1-16: Attractor analysis of p53 gene network in colon cancer
Authors: Man-Sun Kim, Jeong-Rae Kim
Journal: Cancer Research (2015)

Abstract Colon cancer is a heterogeneous and complex disease. Mutation of the p53 gene is most commonly observed in many people with colon cancer [1-2]. In this regard, to understand how the p53 network controls cell fate, it is important not only to identify the network components and their molecular interactions but also to study essential network properties at the system level [3]. However, the molecular mechanisms remain largely unexplored. Here, we used Boolean network modeling and attractor landscape analysis to analyze the state transition dynamics of a simplified p53 network. We first constructed a simplified Boolean network model with multiple feedback loops through p53 for analyzing the p53 network. After building the simplified p53 regulatory network, we modeled the network dynamics using a Boolean network with a set of state transition logics defined on the basis of biological evidence. Attractor landscape analysis of dynamics and its regulation can identify potential therapeutic strategies for treating cancer. Citation Format: Man-Sun Kim, Jeong-Rae Kim. Attractor analysis of p53 gene network in colon cancer. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B1-16.
Comparison of primary site biopsies and transverse surgical sections of squamous cell carcinoma of the head and neck for translational research analysis.
Authors: M. Hambek, S. Mörtel, J. Wagenblast, A. Eckardt, T. Stöver
Journal: Journal of Clinical Oncology (2010)

5522 Background: In order to determine the value of taking biopsies for translational investigations we evaluated the impact of two different biopsy methods, a core-needle and a superficial biopsy in comparison to a surgical gained transverse section of the tumor. The results of immunhistochemical staining of the samples for EGFR and the proliferation antigen Ki67 were compared. Methods: Over a period of 19 month 24 patients were included in this study and underwent a surgical treatment of their HNSCC primary tumor in our institute. The main including criteria were patients with histological proved primary SCCHN and a signed inform consent for the study. Of the surgical resected tumor we took two different types of biopsy, one superficial biopsy and one core-needle biopsy through the cross section of the primary tumor. As a positive control we took one tissue slide trough the primary tumor. The tissues were analyzed immunohistochemical on the expression of Ki67 and EGFR. Results: From all patients sufficient tissue samples could be gained and all immunhistological stained for EGFR- and Ki67-expression. The immunohistological analysis of the expression of EGFR showed that neither the superficial nor the core biopsy correlates significant (p>0.05) with the representative transverse section through the tumor. The analysis of the expression of the proliferation marker Ki67 show that the core biopsy does not correlate significant (p>0.05) with the transverse tumor section as well. However the expression of Ki67 in the superficial biopsy correlates significant (p<0.05) with the transverse tumor section. Additionally a calculation has been performed, how many core biopsies should be taken to get a nearly representative statement in case of translative questions. Conclusions: The results show that both biopsy methods are not applicable for gaining material for translational research, because they do not offer a high degree of reliability. No significant financial relationships to disclose.
TCT-353 Long-term Clinical Outcomes in Patients with Renal Insufficiency After Sirolimus-eluting Stent Implantation: Five-year Follow-up Results of the J-Cypher Registry
Authors: Yasushi Fuku, Kazushige Kadota, Seiji Habara, Hiroyuki Tanaka, Tsuyoshi Goto, Kazuaki Mitsudo, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2013)
Transthoracic approach in adult Morgagni hernias: 30 years experience
Authors: Serpil Sevinc, Kenan Can Ceylan, Ahmet Ucvet, Ozan Usluer, Saban Unsal, Seyda Ors Kaya
Journal: European Respiratory Journal (2011)

Bacground:  Morgagni hernia is a rare congenital disorder. Numerous approaches have been described and, particularly the significance of laparotomy has been emphasized as an operative technique.   Aims and objectives:  To present our experience on adult patients with Morgagni hernia operated on via transthoracic approach in our department.   Methods:  Between 1980 and 2010, 33 patients with Morgagni hernia were operated in our department. Their ages ranged from 17 to 77 years (mean 53.17). There were 17 females. Chest x-rays, thorax computed tomography, magnetic resonance imaging, barium enema, and pneumoperitoneum were used as diagnostic utilities. Thoracotomy was performed in all cases. In only one case, laparotomy was applied in addition to thoracotomy.   Results:  Twenty-five hernias (76%) were right-sided and eight (24%) were left-sided. Hernia sac was present in all cases. Exploration revealed only omentum in 11 patients (33.3%), colon and omentum in 13 patients (39.3%), only colon in three patients (9%), stomach, colon and omentum in two patients (6%), only small bowel in two patients (6%), stomach and omentum in one patient (3%), and only stomach in one patient (3%). There were no complications and no mortalities. There was no recurrence or symptoms related to the operation. The mean follow-up was 11 years.   Conclusions:  We advocate transthoracic approach for surgical exposure as it provides wide exposure and repair of Morgagni hernia.
Vascular endothelial growth factor (VEGF) level in differantial diagnosis of malignant and benign effusion
Authors: M. A. Kaplan, A. Isikdogan, S. B. Zincircioglu, T. Poyraz, T. Cil, M. Kucukoner, A. Inal, I. Yildiz, S. Batun, S. Kalkanli
Journal: Journal of Clinical Oncology (2010)

e21114 Background: The diagnosis of malignant effusions is established by cytologically and histologically. But, in numerous patients, diagnosis cannot be performed by recurrent cytologic investigations. Tumor markers and cytokines have been worked out for correction the diagnosis. Recent studies report high levels of vascular endothelial growth factor (VEGF) in malignant and inflammatory effusions. VEGF is the most specific mytogenic factor for endothelial cells that has been known. It plays important roles in vasculogenesis and angiogenesis. The aim of the study is to show the calculated VEGF levels in the serum and effusions of patients for the diagnosis of benign and malignant effusions. Methods: 25 patients wtih malignant effusion (patient group) and 25 patients with benign effusion (control group) are included the study. Patient groups were divided into 5 subgroups, which contain 5 patients each (ovarian carcinoma subgroup, breast carcinoma subgroup, lung cancer subgroup, malignant pleural mesothelioma subgroup, stomach cancer subgroup). Decompanse cirrhosis (results of hepatitis B and C) patients and heart failure patients were studied as control group. VEGF levels were evaluated in serum and effusions in the patient group, and in effusions in the control group. Results: Average calculated VEGF levels were: 493.8025 pg/mL in the patient group's effusions and 15.4312 pg/mL in the control group's effusions. The average levels of VEGF in patient group were calculated highly statically (p<0.05). Average blood serum VEGF levels in the patient group was 49.9079 pg/mL. The differences of blood serum and effusion VEGF levels of the patient group were meaningful statistically (p<0.05). Conclusions: We think that evaluation of the VEGF levels, as additional to other diagnostic parameters, is useful and non-invasive technique for the diagnosing of malignant and/or benign effusions. No significant financial relationships to disclose.
Solid Cancers After Bone Marrow Transplantation
Authors: Smita Bhatia, Andrew D. Louie, Ravi Bhatia, Margaret R. O’Donnell, Henry Fung, Ashwin Kashyap, Amrita Krishnan, Arturo Molina, Auayporn Nademanee, Joyce C. Niland, Pablo A. Parker, David S. Snyder, Ricardo Spielberger, Anthony Stein, Stephen J. Forman
Journal: Journal of Clinical Oncology (2001)

PURPOSE: To evaluate the incidence and associated risk factors of solid cancers after bone marrow transplantation (BMT). PATIENTS AND METHODS: We analyzed 2,129 patients who had undergone BMT for hematologic malignancies at the City of Hope National Medical Center between 1976 and 1998. A retrospective cohort and nested case-control study design were used to evaluate the role of pretransplantation therapeutic exposures and transplant conditioning regimens. RESULTS: Twenty-nine patients developed solid cancers after BMT, which represents a two-fold increase in risk compared with a comparable normal population. The estimated cumulative probability (± SE) for development of a solid cancer was 6.1% ± 1.6% at 10 years. The risk was significantly elevated for liver cancer (standardized incidence ratio [SIR], 27.7; 95% confidence interval [CI], 1.9 to 57.3), cancer of the oral cavity (SIR, 17.4; 95% CI, 6.3 to 34.1), and cervical cancer (SIR, 13.3; 95% CI, 3.5 to 29.6). Each of the two patients with liver cancer had a history of chronic hepatitis C infection. All six patients with squamous cell carcinoma of the skin had chronic graft-versus-host disease. The risk was significantly higher for survivors who were younger than 34 years of age at time of BMT (SIR, 5.3; 95% CI, 2.7 to 8.6). Cancers of the thyroid gland, liver, and oral cavity occurred primarily among patients who received total-body irradiation. CONCLUSION: The risk of radiation-associated solid tumor development after BMT is likely to increase with longer follow-up. This underscores the importance of close monitoring of patients who undergo BMT.
Multiple Antigens as Marker Substances in Germinal Tumors of the Testis
Authors: Britta Wahren, Elliot Alpert, Pier Esposti
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Multiple Antigens as Marker Substances in Germinal Tumors of the Testis Get access Britta Wahren, Britta Wahren Search for other works by this author on: Oxford Academic PubMed Google Scholar Elliot Alpert, Elliot Alpert Search for other works by this author on: Oxford Academic PubMed Google Scholar Pier Esposti Pier Esposti Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 58, Issue 3, March 1977, Pages 489–498, https://doi.org/10.1093/jnci/58.3.489 Published: 01 March 1977 Article history Received: 31 October 1975 Revision received: 27 July 1976 Accepted: 16 August 1976 Published: 01 March 1977
Abstract P003: Serum Urate and Subclinical Atherosclerosis: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Authors: Huifen Wang, David R Jacobs, Angelo L Gaffo, Myron D Gross, David C Goff, J. Jeffrey Carr
Journal: Circulation (2012)

Background: Elevated serum urate (sUA) has been related to risk of cardiovascular disease (CVD), while evidence is limited among young and apparently healthy populations. Objective: To examine whether sUA concentration is positively associated with subclinical atherosclerosis as reflected in coronary artery calcified plaque (CAC), aortoiliac artery calcified plaque (AoIC), common carotid intima-media thickness (cCIMT), and carotid stenosis, among young adults. Methods: The Coronary Artery Risk Development in Young Adults (CARDIA) Study tracked a cohort of 5,115 black and white adults aged 18-30 years since 1985-86 (year 0), with 7 subsequent examinations at approximately 5 year intervals. sUA concentration was assayed at years 0, 10, 15, and 20, while subclinical atherosclerosis was measured at years 15 (i.e. CAC), 20 (i.e. CAC, carotid stenosis, and cCIMT) and 25 (i.e. CAC and AolC). A dietary history questionnaire was administered at year 0, 7 and 20. Logistic and generalized linear regressions were used as appropriate to examine the relations of sUA at year 0 or 20 with subclinical atherosclerosis. sUA was modeled as continuous variable or gender-specific quartiles that were pooled for the analyses. Covariates at the year of sUA measurement were selected and adjusted in the models based on biological relevance and statistically significant confounding effects. Results: The mean (standard deviation [SD]) year 20 sUA concentrations were 6.61 (1.29) mg/dL in men and 4.95 (1.15) mg/dL in women. Adjusting for year 20 age, sex, race, clinic, education, physical activity, smoking status, and intakes of alcohol, protein and total calories, per SD higher year 20 sUA concentration was associated with 26% (95% confidence interval [CI]=9-44%) and 18% (95%CI=3-34%) higher risk of the presence of CAC at years 20 and 25, respectively. However, further adjustment for year 20 body mass index (BMI) and other metabolic factors (i.e. full model) substantially attenuated these relations. In contrast, the positive associations between year 20 sUA and the presence of AolC at year 25 or cCIMT at year 20 retained statistical significance in the model including BMI and metabolic factors: the odds ratio of year 25 AoIC was 1.38 (95%CI=1.03-1.86) for the highest vs. lowest year 20 sUA quartile; and per SD higher sUA was related to 0.01mm greater year 20 cCIMT (p=0.002). Year 20 sUA was not related to carotid stenosis. Parallel analysis using year 0 sUA as the predictor variable and year 0 covariates found a similar pattern in relation to years 15, 20 and 25 subclinical atherosclerosis markers, which, however, were all attenuated to non-significance in the year 0 full model. Conclusion: The sUA concentration may be an early biomarker for subclinical atherosclerosis in young adults prior to the development of clinical CVD, operating in part through its relation with BMI and other metabolic factors.
Morphology of the Oncogenic Response of Hamsters to Polyoma Virus Infection
Authors: Mearl F. Stanton, Hisashi Otsuka
Journal: JNCI Journal of the National Cancer Institute (1963)

The distribution, morphology, and pathogenesis of tumors occurring in 274 hamsters subcutaneously inoculated with different dilutions of fluid from cultures of mouse embryo cells infected with polyoma virus are described. Inflammatory and specific degenerative changes preceded tumors in some sites, but not all sites. The kidney, heart, liver, and subcutaneous tissues were common sites of primary tumors, but other sites may be affected. Unique metastases from the earliest proliferative lesions occurred in the lung. Some tumors in the liver were simple cystic angiomas composed of endothelial cells; focal proliferation of renal tubules in a few animals was the only response of epithelium observed. The solid tumors in all sites had common structural characteristics suggesting origin from poorly differentiated mesenchyme possibly associated with components of the vascular wall. Tumors varied little in structure, but subcutaneous and cardiac tumors additionally contained fat cells, and cardiac and bone marrow tumors contained areas of atypical osteogenesis. The number of primary tumor foci in an organ was determined by the amount of tissue culture fluid inoculated. With large doses, confluent tumor foci developed that were rapidly lethal; with smaller doses, tumor foci with the same histologic characteristics developed but they were isolated, which allowed longer survival. The histology and apparent behavior of the tumors in the surviving animals indicated a few had all the qualities of highly malignant fibrosarcomas, while others lost even the simple ability to continue proliferation. Most tumors continued to grow, but formed ever-expanding, circumscribed nodules with limited ability to invade or destroy tissues. These nodules may be exceptionally valuable research tools, since their cells seemed to deviate from normal immature cells only in the ability to continue growth.