tbuckley/cabot-search huggingface dataset:
Evaluation of Dermatology Practice Online Reviews
Authors: Robert J. Smith, Jules B. Lipoff
Journal: JAMA Dermatology (2015)

Patient satisfaction is an increasingly important component of health care quality measures. Online reviews of physicians represent a promising platform for capturing patient perspectives of care.To identify qualitative themes associated with patient reviews of dermatologic care on consumer reporting websites.A qualitative analysis was conducted of patient-generated reviews of dermatology practices on 2 consumer review platforms. Yelp is an online consumer portal for users to review their experience with local businesses; ZocDoc is an online patient-scheduling portal that provides opportunity for patients to write reviews of physician practices. A total of 518 reviews from 45 dermatology practices on Yelp and 4921 reviews from 45 dermatology providers on ZocDoc were collected from 3 geographically diverse cities: Philadelphia, Pennsylvania; Houston, Texas; and Seattle, Washington. The study was conducted from January 15 to July 15, 2015.Reviews were separated into high-scoring and low-scoring groups. An inductive qualitative method was used to code and identify key themes associated with positive and negative patient experiences. Analysis was completed upon reaching thematic saturation.Reported as mean (95% CI), the overall Yelp score for the 45 selected practices was 3.46 of 5 stars (3.17-3.75) and overall ZocDoc score for the 45 selected practices was 4.72 of 5 stars (4.47-4.80). The proportion of individual reviews giving a score of 5.0 was significantly higher on ZocDoc (3986 [81.0%]) than on Yelp (229 [44.2%]) (P < .001). Qualitative themes centered on characteristics of the physician and the practice. Themes that emerged from the high-scoring and low-scoring reviews were similar in content but opposite in valence. Physician-specific themes included temperament, knowledge and competency, physical examination, communication abilities, and mindfulness of cost. Practice-specific themes included scheduling, staff temperament, office cleanliness, waiting room, and insurance. Patients appreciated physicians who are kind, respectful, and thorough with the physical examination; empathetic about the emotional difficulty of skin disease; and cognizant of cost. Negative experiences were frequently affected by considerations outside of the physician-patient interaction, such as curt interactions with staff, difficulty with scheduling, practice cleanliness, and insurance problems. Patients reported relying on consumer websites to identify dermatology providers.Online consumer review websites are designed to facilitate instantaneous and public communication among patients. These platforms provide elaborate and timely data for dermatologists to garner insight into their patients' experiences. The themes identified in this study are consistent with past satisfaction studies and may aid dermatologists in optimizing the patient care experience.
Policies for study monitoring and interim reporting of results.
Authors: S J Green, T R Fleming, J R O'Fallon
Journal: Journal of Clinical Oncology (1987)

Interim analyses of comparative trials are necessary in order to monitor for extreme therapeutic results. However, closing studies and reporting results whenever "trends" appear increases the probability of a false conclusion to well over the desired .05 level. Guidelines for early stopping of comparative trials must be carefully defined to avoid this problem. In addition, to avoid inappropriate early closure of studies due to declining accrual (as investigators draw their own conclusions from early unreliable data), it is recommended that access to interim data be limited to a multidisciplinary monitoring committee responsible for (1) performing and reviewing interim analyses, and (2) deciding when early termination should be considered. Accrual and reporting of studies from two clinical trials groups, one with a policy of limited access to interim data and one without, are compared. The group without monitoring committees had a higher incidence of accrual and reporting problems than the group with monitoring committees.
Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
Authors: Maria Szaruga, Sarah Veugelen, Manasi Benurwar, Sam Lismont, Diego Sepulveda-Falla, Alberto Lleo, Natalie S. Ryan, Tammaryn Lashley, Nick C. Fox, Shigeo Murayama, Harrie Gijsen, Bart De Strooper, Lucía Chávez-Gutiérrez
Journal: The Journal of Experimental Medicine (2015)

Presenilin (PSEN) pathogenic mutations cause familial Alzheimer’s disease (AD [FAD]) in an autosomal-dominant manner. The extent to which the healthy and diseased alleles influence each other to cause neurodegeneration remains unclear. In this study, we assessed γ-secretase activity in brain samples from 15 nondemented subjects, 22 FAD patients harboring nine different mutations in PSEN1, and 11 sporadic AD (SAD) patients. FAD and control brain samples had similar overall γ-secretase activity levels, and therefore, loss of overall (endopeptidase) γ-secretase function cannot be an essential part of the pathogenic mechanism. In contrast, impaired carboxypeptidase-like activity (γ-secretase dysfunction) is a constant feature in all FAD brains. Significantly, we demonstrate that pharmacological activation of the carboxypeptidase-like γ-secretase activity with γ-secretase modulators alleviates the mutant PSEN pathogenic effects. Most SAD cases display normal endo- and carboxypeptidase-like γ-secretase activities. However and interestingly, a few SAD patient samples display γ-secretase dysfunction, suggesting that γ-secretase may play a role in some SAD cases. In conclusion, our study highlights qualitative shifts in amyloid-β (Aβ) profiles as the common denominator in FAD and supports a model in which the healthy allele contributes with normal Aβ products and the diseased allele generates longer aggregation-prone peptides that act as seeds inducing toxic amyloid conformations.
A CONTRIBUTION TO THE STUDY OF CLUB-HAND.
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Role of Diet in the Etiology and Treatment of Atherosclerosis
Authors: P Samuel, D J McNamara, J Shapiro
Journal: Annual Review of Medicine (1983)

The role of various dietary constituents in the etiology of hyperlipidemia and cardiovascular disease is examined in light of currently available data from epidemiological and clinical studies. Recommendations regarding the dietary management of the hyperlipidemic patient at risk are presented and the advisability of generalized dietary guidelines for the public examined. The certainties, which are few, and the uncertainties, which are numerous, regarding the cause and effect relationship between diet, hyperlipidemia, and cardiovascular disease suggest that dietary intervention to treat the hyperlipidemic patient is a rational first step but that the generalization of this approach for the public may be premature.
U.S. Army Psychiatry in the Vietnam War: New Challenges in Extended Counterinsurgency Warfareby Norman M. Camp, M.D. Fort Sam Houston, Tex., Office of the Surgeon General, Borden Institute, U.S. Army Medical Department Center &amp; School, 2015, 596 pp., $101.00 (hardcover).
Authors: Jason I. Dailey
Journal: American Journal of Psychiatry (2015)
Very Late Scaffold Thrombosis
Authors: Lorenz Räber, Salvatore Brugaletta, Kyohei Yamaji, Crochan J. O’Sullivan, Shuji Otsuki, Tobias Koppara, Masanori Taniwaki, Yoshinobu Onuma, Xavier Freixa, Franz R. Eberli, Patrick W. Serruys, Michael Joner, Manel Sabaté, Stephan Windecker
Journal: Journal of the American College of Cardiology (2015)
Hunt says financial pressures on NHS are “worst ever”
Authors: Adrian O’Dowd
Journal: BMJ (2015)

The financial pressures on the NHS are at their worst ever but the health service will balance its books by the end of this financial year, the health secretary has told MPs.

Jeremy Hunt appeared before the parliamentary health select committee on 15 September for an oral evidence inquiry session on the work of the health secretary.

In a wide ranging discussion MPs challenged Hunt on various topics including a seven day a week NHS, staff pay, efficiency savings, deficits, GP workload pressures, agency staffing costs, public health, social care, winter pressures, mental health, and staff morale.

In frank responses, Hunt acknowledged record pressures on NHS finances and said that staff morale was low, …
Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes
Authors: José Manuel Fernández-Real, Donald McClain, Melania Manco
Journal: Diabetes Care (2015)

The bidirectional relationship between iron metabolism and glucose homeostasis is increasingly recognized. Several pathways of iron metabolism are modified according to systemic glucose levels, whereas insulin action and secretion are influenced by changes in relative iron excess. We aimed to update the possible influence of iron on insulin action and secretion and vice versa.The mechanisms that link iron metabolism and glucose homeostasis in the main insulin-sensitive tissues and insulin-producing β-cells were revised according to their possible influence on the development of type 2 diabetes (T2D).The mechanisms leading to dysmetabolic hyperferritinemia and hepatic overload syndrome were diverse, including diet-induced alterations in iron absorption, modulation of gluconeogenesis, heme-mediated disruption of circadian glucose rhythm, impaired hepcidin secretion and action, and reduced copper availability. Glucose metabolism in adipose tissue seems to be affected by both iron deficiency and excess through interaction with adipocyte differentiation, tissue hyperplasia and hypertrophy, release of adipokines, lipid synthesis, and lipolysis. Reduced heme synthesis and dysregulated iron uptake or export could also be contributing factors affecting glucose metabolism in the senescent muscle, whereas exercise is known to affect iron and glucose status. Finally, iron also seems to modulate β-cells and insulin secretion, although this has been scarcely studied.Iron is increasingly recognized to influence glucose metabolism at multiple levels. Body iron stores should be considered as a potential target for therapy in subjects with T2D or those at risk for developing T2D. Further research is warranted.
Ovarian suppression using luteinizing hormone-releasing hormone agonists during chemotherapy to preserve ovarian function and fertility of breast cancer patients: a meta-analysis of randomized studies
Authors: M. Lambertini, M. Ceppi, F. Poggio, F.A. Peccatori, H.A. Azim, D. Ugolini, P. Pronzato, S. Loibl, H.C.F. Moore, A.H. Partridge, P. Bruzzi, L. Del Mastro
Journal: Annals of Oncology (2015)
Dose Adjustment During Pollen Seasons in Build-up and Maintenance Vials Lowers the Risk of Severe Systemic Reactions (SRs) to Subcutaneous Allergen Immunotherapy (SCIT): Year 4 of the AAAAI/ACAAI Surveillance Study
Authors: Tolly Epstein, Gary M. Liss, Karen Murphy Berendts, David I. Bernstein
Journal: Journal of Allergy and Clinical Immunology (2013)
Effects of Diet on Lipoprotein Metabolism
Authors: A C Goldberg, G Schonfeld
Journal: Annual Review of Nutrition (1985)

INTRODUCTION .....         195 OVERVIEW OF LIPOPROTEIN METABOLISM   :....... 196 DIETARY FAT AND CHOLESTEROL . . . . . . . ...... . ...... . . . . . . . . . . . . .. . . . . . . . . . . . . . . .. . . . . . . . . 197 Population Surveys ........     198 Acute Feeding of High-Fat, High-Cholesterol Diets .... .     198 Prolonged Feeding of High-Fat, High-Cholesterol Diets   199 Effects of High-Fat, High-Cholesterol Diets on Apoproteins .....   .. 201 Effects of Low-Cholesterol, High-Polyunsaturated-Fat Diets ....     201 Fish Oils.   . .   . . .   . . . . ...... . . .   .. . .. . . ... ... 203 CARBOHyDRATE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 PROTEIN . ...... . . . . . . . . ...... . . . . . . . . . ... .. . . . . . . . . . . . . . . . .... . . . . . . . . . . . . . . . . ... . . . . . . . . .. . .. . . . . . . . .. 205 DIETARY FIBER  206 FUTURE DIRECTIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 208
The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia
Authors: Kei Yamamoto, Yoshimi Miki, Mariko Sato, Yoshitaka Taketomi, Yasumasa Nishito, Choji Taya, Kazuaki Muramatsu, Kazutaka Ikeda, Hiroki Nakanishi, Ryo Taguchi, Naotomo Kambe, Kenji Kabashima, Gérard Lambeau, Michael H. Gelb, Makoto Murakami
Journal: The Journal of Experimental Medicine (2015)

Epidermal lipids are important for skin homeostasis. However, the entire picture of the roles of lipids, particularly nonceramide lipid species, in epidermal biology still remains obscure. Here, we report that PLA2G2F, a functionally orphan-secreted phospholipase A2 expressed in the suprabasal epidermis, regulates skin homeostasis and hyperplasic disorders. Pla2g2f−/− mice had a fragile stratum corneum and were strikingly protected from psoriasis, contact dermatitis, and skin cancer. Conversely, Pla2g2f-overexpressing transgenic mice displayed psoriasis-like epidermal hyperplasia. Primary keratinocytes from Pla2g2f−/− mice showed defective differentiation and activation. PLA2G2F was induced by calcium or IL-22 in keratinocytes and preferentially hydrolyzed ethanolamine plasmalogen-bearing docosahexaenoic acid secreted from keratinocytes to give rise to unique bioactive lipids (i.e., protectin D1 and 9S-hydroxyoctadecadienoic acid) that were distinct from canonical arachidonate metabolites (prostaglandins and leukotrienes). Ethanolamine lysoplasmalogen, a PLA2G2F-derived marker product, rescued defective activation of Pla2g2f−/− keratinocytes both in vitro and in vivo. Our results highlight PLA2G2F as a previously unrecognized regulator of skin pathophysiology and point to this enzyme as a novel drug target for epidermal-hyperplasic diseases.
Doenças crônicas não transmissíveis no Brasil: carga e desafios atuais
Authors: Maria Inês Schmidt, Bruce Bartholow Duncan, Gulnar Azevedo e Silva Mendonça, Ana Maria Baptista Menezes, Carlos Augusto Monteiro, Sandhi Maria Barreto, Dora Chor, Paulo Rossi Menezes
Journal: The Lancet (2011)
FGF acts as a co-transmitter through adenosine A2A receptor to regulate synaptic plasticity
Authors: Marc Flajolet, Zhongfeng Wang, Marie Futter, Weixing Shen, Nina Nuangchamnong, Jacob Bendor, Iwona Wallach, Angus C Nairn, D James Surmeier, Paul Greengard
Journal: Nature Neuroscience (2008)
Anti-Egfr Antibody Rechallenge in Chemorefractory Patients with Metastatic Colorectal Cancer
Authors: Tatsuhiro Kajitani, Akitaka Makiyama, Shuji Arita, Hozumi Kumagai, Hisanobu Oda, Tsuyoshi Shirakawa, Taito Esaki
Journal: Annals of Oncology (2014)
The Biochemical Functions of Ascorbic Acid
Authors: S Englard, S Seifter
Journal: Annual Review of Nutrition (1986)

SCOPE OF THIS REVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 365 BIOSYNTHESIS AND REQUIREMENTS OF ASCORBIC ACID . . . . . . . . . . . . . . . . . . . . . . . . . 366 METABOLISM OF ASCORBATE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 367 ACTIONS AND FUNCTIONS OF ASCORBATE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 368 DOPAMINE !3-HYDROXYLASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . 372 PEPTIDYL GLYCINE a-AMIDATING MONOOXYGENASE... . . . . . . . . . . . . . . . . . . . . . . . . . . . 373 4-HYDROXYPHENYLPYRUV ATE DIOXYGENASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 374 PROL YL AND L YSYL HYDROXYLASES FOR COLLAGENS . . . . . . . . . . . . . . . . . . . . . . . . . . . 376 HYDROXYLATION OF OTHER PROTEINS . . . ..   . . ......   . . .   . 383 Elastin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 383 C1q o/ Complement. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 384 DIOXYGENASE REACTIONS OF PYRIMIDINES AND NUCLEOSIDES . . . . . . . . . . . . . . 385 CARNITINE PATHWAY HYDROXYLASES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 386 OTHER POSSIBLE FUNCTIONS OF ASCORBATE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 391 CONCLUDING REMARKS ... . . ........ . . . . . .. . .. . .. . . ...... .... . . ........ .... ..... .   . . . 391
Reduction of Bone Mineral Density (BMD) in IgE-Mediated Cow's Milk Protein (CMP) Allergy and Normalization After Tolerance Acquisition by Oral Immunotherapy
Authors: Liat Nachshon, Michael Goldberg, Arnon Elizur, Michael B. Levy, Yitzhak Katz
Journal: Journal of Allergy and Clinical Immunology (2013)
Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage
Authors: Mark J. Pearson, Ashleigh M. Philp, James A. Heward, Benoit T. Roux, David A. Walsh, Edward T. Davis, Mark A. Lindsay, Simon W. Jones
Journal: Arthritis & Rheumatology (2015)

Objective To identify long noncoding RNAs (lncRNAs), including long intergenic noncoding RNAs (lincRNAs), antisense RNAs, and pseudogenes, associated with the inflammatory response in human primary osteoarthritis (OA) chondrocytes and to explore their expression and function in OA. Methods OA cartilage was obtained from patients with hip or knee OA following joint replacement surgery. Non‐OA cartilage was obtained from postmortem donors and patients with fracture of the neck of the femur. Primary OA chondrocytes were isolated by collagenase digestion. LncRNA expression analysis was performed by RNA sequencing (RNAseq) and quantitative reverse transcriptase–polymerase chain reaction. Modulation of lncRNA chondrocyte expression was achieved using LNA longRNA GapmeRs (Exiqon). Cytokine production was measured with Luminex. Results RNAseq identified 983 lncRNAs in primary human hip OA chondrocytes, 183 of which had not previously been identified. Following interleukin‐1β (IL‐1β) stimulation, we identified 125 lincRNAs that were differentially expressed. The lincRNA p50‐associated cyclooxygenase 2–extragenic RNA (PACER) and 2 novel chondrocyte inflammation–associated lincRNAs (CILinc01 and CILinc02) were differentially expressed in both knee and hip OA cartilage compared to non‐OA cartilage. In primary OA chondrocytes, these lincRNAs were rapidly and transiently induced in response to multiple proinflammatory cytokines. Knockdown of CILinc01 and CILinc02 expression in human chondrocytes significantly enhanced the IL‐1–stimulated secretion of proinflammatory cytokines. Conclusion The inflammatory response in human OA chondrocytes is associated with widespread changes in the profile of lncRNAs, including PACER, CILinc01, and CILinc02. Differential expression of CILinc01 and CIinc02 in hip and knee OA cartilage, and their role in modulating cytokine production during the chondrocyte inflammatory response, suggest that they may play an important role in mediating inflammation‐driven cartilage degeneration in OA.
Multicenter Phase II Trial of Paclitaxel, Cisplatin, and Etoposide With Concurrent Radiation for Limited-Stage Small-Cell Lung Cancer
Authors: Roy M. Bremnes, Stein Sundstrøm, Jan Vilsvik, Ulf Aasebø
Journal: Journal of Clinical Oncology (2001)

To investigate the feasibility, efficacy, and safety of adding paclitaxel to cisplatin/etoposide chemotherapy and concurrent thoracic radiotherapy (TRT) in treatment of limited-stage small-cell lung cancer (LD-SCLC).Patients received five courses of chemotherapy (paclitaxel 175 mg/m2 1-hour intravenous [IV] infusion day 1; cisplatin 50 mg/m(2) IV day 1; etoposide 100 mg/m2 IV day 1; oral etoposide 100 mg bid days 2 to 5) at 3-week intervals. TRT (42 Gy administered in 15 fractions) was administered concurrent with chemotherapy cycle 3. All patients were evaluated before starting TRT and 4 weeks after termination of chemotherapy. Patients achieving complete remission (CR) were administered prophylactic cranial irradiation.Thirty-nine patients were included, and the median age was 63 years. The median follow-up was 36 months (range, 19 to 57 months). The overall response rate was 92% (CR, 81%; partial response, 11%), and the median survival was 21 months. The 1- and 2-year disease-specific survival rates were 69% and 37%, respectively. Of 29 CR patients, 83% have relapsed. Brain metastasis was as frequent as local recurrences (42%). Hematologic toxicity included grade 3 to 4 leukopenia in 74% of patients and grade 3 thrombocytopenia in 10%. One treatment-related death occurred as a result of severe neutropenia and septicemia. Hematotoxicity caused dose reductions in 31% of courses. One patient had an anaphylactic reaction during the first paclitaxel infusion. Paclitaxel-related neuropathy and myalgia were reversible. Grade 3 esophagitis was seen in five patients during and shortly after TRT.This novel multimodal regimen is effective and well tolerated in patients with LD-SCLC. It compares favorably with previously published phase II studies.
A Putative Role of Hypercholesterolemia in Progressive Glomerular Injury
Authors: Jonathan R. Diamond, Morris J. Karnovsky
Journal: Annual Review of Medicine (1992)

Recently, much experimental evidence has accumulated contending that hypercholesterolemia is an aggravating factor in the progression of initial glomerular injury to glomerulosclerosis. Many of the features of progressive glomerular disease share biological properties with those of atherosclerosis, and data suggesting a noxious role for oxidized low-density lipoprotein in the glomerulosclerosis process are emerging. This review discusses these issues and examines the pathobiology of cholesterol-induced glomerular injury.
Neurodata Without Borders: Creating a Common Data Format for Neurophysiology
Authors: Jeffery L. Teeters, Keith Godfrey, Rob Young, Chinh Dang, Claudia Friedsam, Barry Wark, Hiroki Asari, Simon Peron, Nuo Li, Adrien Peyrache, Gennady Denisov, Joshua H. Siegle, Shawn R. Olsen, Christopher Martin, Miyoung Chun, Shreejoy Tripathy, Timothy J. Blanche, Kenneth Harris, György Buzsáki, Christof Koch, Markus Meister, Karel Svoboda, Friedrich T. Sommer
Journal: Neuron (2015)