tbuckley/cabot-search huggingface dataset:
Detection of a New Antigen Associated With Chicken Thrombocytes on Marek's Disease Lymphoblastoid Cell Line&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: T Higashihara, T Mikami, H Kodama, H Izawa, H Tamura
Journal: JNCI Journal of the National Cancer Institute (1986)

A monoclonal antibody, 2C12, produced against MDCC-MSB1 cells, reacted with several cell lines derived from Marek's disease (MD), including MDCC-MSB1 cells, normal chicken thrombocytes, and MD tumor cells. It did not react with cell lines derived from avian leukosis or reticuloendotheliosis, cells from normal chicken thymus and bursa, chicken kidney cells and quail fibroblast cultures inoculated with MD virus, or with erythrocytes from 1-day-old and adult chickens, cow, sheep, and horse. Anti-thrombocyte serum prepared in a rabbit reacted with thrombocytes and MDCC-MSB1 cells. The specificities of antibody 2C12 and anti-thrombocyte serum against MDCC-MSB1 cells and thrombocytes were confirmed by cross-absorption, blocking, and double-membrane fluorescent antibody tests. The existence of a polypeptide with an apparent molecular weight of 103,000, common to both MDCC-MSB1 cells and thrombocytes, was demonstrated by Western blotting analyses.
A Retrospective Analysis of the Efficacy and Safety of Regorafenib in Patients with Chemo-Refractory Colorectal Cancer
Authors: Takayuki Oishi, Masanobu Takahashi, Masatoshi Shiono, Shin Takahashi, Shoko Akiyama, Hidekazu Shirota, Hideki Shimodaira, Shunsuke Kato, Chikashi Ishioka
Journal: Annals of Oncology (2014)
Correlation of Cks1 and p27<sup>kip1</sup> with tumor biologic aggressiveness and survival in gastrointestinal stromal tumor
Authors: J. W. Horvath, W. Frankel, A. Bellizzi, K. Guenterberg, O. H. Iwenofu
Journal: Journal of Clinical Oncology (2009)

e15549 Background: The biologic behavior of gastrointestinal stromal tumors (GIST) based upon morphologic parameters is unpredictable. Cyclin dependent kinase-1 (Cks1) plays an important role in the ubiquitination and proteolysis of p27 kip1 , a negative regulator of protein kinase Cdk2/cyclin E and Cdk2/cyclin A. This study was to ascertain whether Cks1 overexpression and p27 kip1 downregulation were predictive of biologic aggressiveness and overall survival in GIST. Methods: Tissue microarray was built from 61 patients with GIST. Pathology reports as well as clinical follow-up were retrieved. Sections were stained with antibodies to p27 kip1 and Cks1. Staining was scored for quantity of tumor cells (%) and intensity (0, 1+ weak staining, 2+ strong staining), and a score was calculated from the product of intensity and %. Tumors were evaluated for correlation of p27 kip1 and Cks1 expression level with overall survival time and tumor risk stratification. Tumor risk stratification was classified into very low risk, low risk, intermediate risk, and high risk, and is reflective of intrinsic biologic aggressiveness. Actuarial survival curves were estimated using Kaplan Meier method. Results: The tumors show a high frequency of Cks1 expression (92%; 1+, n=39; 2+, n=17). The % expression ranged from 0–90% (mean 37%). The p27 kip1 positive rate is 85% (1+, n=20; 2+, n=32). The % expression ranged from 0–90% (mean 48%). Overall survival ranged from 0.1–10.7 years. By univariate analysis of overall survival using Cox regression model, increased p27 kip1 expression (continuous variable) is significantly correlated with overall survival (p=0.04), but Cks1 expression does not (p=0.84). In a univariate analysis of p27 kip1 and Cks1 (continuous variables) with risk stratification of the tumor using F-test, higher tumor grade has significantly higher Cks1 expression values (p=0.0045). Conclusions: Our study shows that with univariate analysis high expression of Cks1 expression is significantly associated with increased intrinsic biologic aggressiveness, while high expression of p27 kip1 is associated with increased overall survival. The lack of correlation of Cks1 and p27 kip1 suggests additional p27 kip1 independent mechanisms might play a role in the oncogenesis of GIST. No significant financial relationships to disclose.
Attachment of Antinuclear Antibodies to Nasopharyngeal Carcinoma or Other Cells During Preparation of Biopsy Imprints&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: W Henle, G Henle, A P Lanier, G W Bornkamm
Journal: JNCI Journal of the National Cancer Institute (1986)

The presence of Epstein-Barr virus (EBV) genomes in nasopharyngeal and other carcinomas or Burkitt's and other B-cell lymphomas can be established by the demonstration of viral nucleic acid sequences in DNA extracts from biopsy specimens, the detection of EBV-associated nuclear antigen (EBNA) in biopsy imprints, and the inhibition of leukocyte migration by tumor extracts. Of these techniques, the detection of EBNA-positive tumor cells can be performed most readily in the laboratory. This report shows that a patient's antibodies to nuclear antigens can gain access to cell nuclei during the preparation of imprints. If the antibodies are directed against EBNA, nuclear immunofluorescence is elicited solely in the tumor cells when only complement (C') and fluorescein-labeled antibodies to C' are applied to the imprints without prior exposure to anti-EBNA-positive sera. If nonspecific antinuclear antibodies (ANA) are involved, the nuclear immunofluorescence seen in the EBNA-specific and control assays is not limited to the tumor cells but extends to any normal cells that may be present in the imprints. Furthermore, nuclear fluorescence is elicited when solely an anti-human IgG conjugate is applied because ANA is measurable by indirect immunofluorescence, whereas detection of EBNA requires augmentation of the antigen-antibody complexes by C', which differentiates further between EBNA-specific and nonspecific staining. Attachment of antibodies to nuclei can be avoided by minimizing the deposit of blood during imprint preparation and by rapid drying of the imprints. Similar results are obtained experimentally when smears of lymphoblasts are made in the presence of anti-EBNA or ANA.
Comparative Study of the Carcinogenic Activity of Nitrosamines&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Mary F. Argus, Cornelia Hoch-Ligeti
Journal: JNCI Journal of the National Cancer Institute (1961)

The carcinogenic activity of dimethyl-, diethyl-, and diphenylnitrosamine and dimethylhydrazine was studied in the rat. The high carcinogenic activity of dimethylnitrosamine and diethylnitrosamine was confirmed; the localization and morphology of the tumors differed from those previously described. Diphenylnitrosamine and dimethylhydrazine had no carcinogenic activity. Dimethylnitrosamine produced tumors with a variety of histological characteristics in the liver, lung, and kidney. Primary malignant tumors arose in 1, 2, or all 3 of these organs of the same rat. In the lung, squamous-cell carcinomas were found either as the only pulmonary tumor or in association with bronchiolar or alveolar adenocarcinoma. Diethyltiitrosamine induced hepatocellular carcinomas in all rats, with metastases into the lung in many instances. One primary kidney tumor was found.
Roles, Functions, and Mechanisms of Long Non-Coding RNAs in Cancer
Authors: Yiwen Fang, Melissa J. Fullwood
Journal: Genomics Proteomics & Bioinformatics (2016)

Abstract Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.
COPD as undetected cause of dyspnea in patients admitted with ischaemic heart disease (IHD)
Authors: Daria Mihailichenko, Tetyana Pertseva
Journal: European Respiratory Journal (2014)

Often it is difficult to distinguish the underlying pathology of dyspnea, from  chronic heart failure (CHF) or from other respiratory causes. As most of the clinical findings in cardiac failure are related to pulmonary involvement, physical findings are usually similar in both conditions.   Aim:  To exclude concomitant obstructive lung diseases in patients with IHD hospitalized due to worsening of dyspnea.   Materials:  100 patients with IHD (age – 67,3±7,4 yrs, male – 33 (33%), female 77 (77%) who were hospitalized with breathlessness. Mean duration of IHD 17,4±1,5 yrs.   Methods: Measurements included clinical status, MRS dyspnea scale,spirometry with reversibility test, X-ray for pulmonary evaluation.   Results:  All the patients had moderate or severe dyspnea (grade 2–4) due to MRS dyspnea scale. According to investigation the external respiration function 61 (61%) patients hadn9t any violation in spirometry, 39 (39%) had newly detected airflow obstruction. These 39% participants also had risk factors for respiratory diseases such as cigarette smoking, obesity and occupational hazards. Among 39 patients, 24 (61,5%) had only a reduced FEV 1 /FVC ratio (0,66±0,05) in combination with a normal value of FEV1% pred. (85,51±11,42). 15 (38,5%) patients had reduced both FEV 1  % pred. (63,68±8,32) and FEV 1 /FVC ratio (0,6±0,08), who were newly diagnosed COPD, which can impact on IHD and leads to worsening of dyspnea.   Conclusion:  About 40% patients of elderly groups with IHD, who were hospitalized with worsening of dyspnea had concomitant obstructive lung diseases. Every third patient had COPD, which hadn9t been diagnosed earlier.
Abstract 13786: Functional Enhancement of Circulating Angiogenic Cells Cultured on a Collagen Biomaterial Using the Cysteine-rich Angiogenic Inducer 61 (CYR-61) Protein
Authors: Brian McNeill, Branka Vulesevic, Marc Ruel, Erik J Suuronen
Journal: Circulation (2013)

BACKGROUND: Therapy with circulating angiogenic cells (CACs) has the ability to promote neovascularization of ischemic tissue. We have previously demonstrated that the culture of CACs on a collagen...
Zika virus outbreaks prompt warnings to pregnant women
Authors: Ingrid Torjesen
Journal: BMJ (2016)

The rapid spread of Zika virus in the Americas, where there is little population immunity, is a major concern, especially given the possible link between infection during pregnancy and the congenital abnormality microcephaly, the World Health Organization has warned.

Margaret Chan, WHO’s director general, said, “Although a causal link between Zika infection in pregnancy and microcephaly has not been established, the circumstantial evidence is suggestive and extremely worrisome. An increased occurrence of neurological syndromes, noted in some countries coincident with arrival of the virus, adds to the concern.”

Travellers should stay informed about Zika virus and take measures to avoid being bitten by mosquitoes, particularly if they are pregnant, WHO has said, but it is not recommending restrictions on travel to affected countries, which include Brazil, Colombia, El Salvador, French Guiana, Guatemala, Haiti, Honduras, Martinique, Mexico, Panama, Paraguay, Puerto Rico, Suriname, and Venezuela.

Because of the possible heightened risk to …
Retrospective review of adjuvant chemotherapy for esthesioneuroblastoma
Authors: D. M. Bernold, V. Khurana, C. Giannini, R. L. Foote, M. J. Link, T. J. Moynihan, J. C. Buckner
Journal: Journal of Clinical Oncology (2005)

5534 Background: Esthesioneuroblastoma is a rare tumor arising from the olfactory epithelium in the upper nasal cavity. Prior reviews have found efficacy of chemotherapy for high grade tumors in the advanced setting. However, little information is available regarding chemotherapy in the adjuvant setting. Methods: A retrospective review of 76 patients treated at the Mayo Clinic for esthesioneuroblastoma from 1976 to 2003 was performed to evaluate adjuvant chemotherapy (AC) in these patients. Pathology slides were reviewed to assign Hyam’s grade, and modified Kadish staging was available for all patients used in the analysis. Results: Twelve patients were identified to have had full surgical resection of stage C, high grade (grade 3 or 4) tumors. Six of these patients received AC, and six did not. Five of the six patients receiving AC also received adjuvant radiation therapy, while three of six patients who did not receive AC received radiation therapy. All AC was cisplatin based. Median time to relapse for patients who did and did not receive AC is 66 months and 10.5 months respectively. The median overall survival (OS) for patients that received AC has not been reached (range 21 to 84+ months). The median OS for patients not receiving AC is 78 months (range 9 to 120+ months). The three patients who received neither chemotherapy nor radiation therapy all relapsed within 3 months with a median OS of 60 months (range 9 to 110 months), while those receiving solely radiation therapy had a median time to relapse of 24 months and a median OS of 96 months (range 42 to 120+ months). Conclusions: This small retrospective series suggests that adjuvant therapy for patients with high grade, stage C esthesioneuroblastoma is of benefit following complete resection. Radiation therapy alone provides an improvement in time to relapse, which is increased further with the addition of cisplatin based chemotherapy. No significant financial relationships to disclose.
Endometrial cancer survivorship in obese patients: A lifestyle intervention program
Authors: V. E. Von Gruenigen, S. Waggoner, H. Gibbons, M. Kavanagh, K. Courneya, E. Lerner
Journal: Journal of Clinical Oncology (2007)

5596 Background: The majority of early stage endometrial cancer (EC) survivors are obese, have cardiovascular disease and are at significant risk of death from causes other than cancer. The purpose of this study was to examine outcomes at 6 and 12 months in obese EC survivors enrolled in a randomized trial of a nutrition and exercise counseling program. Methods: Patients (pts) with early stage (I or II) EC with a body mass index ≥ 25 diagnosed from 1999–2005 were invited to participate. The intervention (I) group received 6 months of nutritional and exercise counseling while the control (C) group received an informational brochure only. Primary outcome variable was weight loss. Quality of life (QoL) was measured by the Functional Assessment of Cancer Therapy-General (FACT-G) and Medical Outcomes Short-form (SF-36) survey. Exercise [leisure score index (LSI)] and eating patterns (quantitative food records) were assessed at baseline, 3, 6 and 12 mos. Repeated measures ANOVA and independent samples t-test were used for analysis. A sample size of 50 pts with a type1=0.05 and type 2=0.20 error rate was used to test the hypothesis that pts in the I group would lose weight as compared to the C group. Results: 45 pts were enrolled and 23 were randomized to I and 22 to the C group, stratified by BMI. Baseline QoL was decreased in morbidly obese pts (BMI ≥ 40) as compared to pts with a BMI &lt; 40 (FACT-G: 78.0 vs. 83.7; p=0.140; physical SF-36: 40.6 vs. 49.1 p=0.008). Women in the I group lost weight and increased exercise over the 12 mos as compared to controls ( Table ). Repeated measures ANOVA demonstrated a borderline significant interaction effect for weight (F=2.7, p=.074) and a significant interaction effect for exercise (F=5.0; p=.005) over time. The I group had lower intake of calories and total fat during the intervention. Conclusions: Obese EC survivors can undergo and maintain positive lifestyle changes. Future studies will examine long-term changes in co-morbidities and mortality. [Table: see text] No significant financial relationships to disclose.
Abstract 12860: TIE2-Expressing Monocytes/Macrophages Promote Recovery from Tissue Ischaemia
Authors: Ashish S Patel, Alberto Smith, Silvia Nucera, Ferdinando Pucci, Prakash Saha, Rizwan Attia, Steven Grover, Oliver Lyons, Katherine Mattock, Julia Humphries, Matthew Waltham, Stuart Egginton, Richard Siow, Aleksandar Ivetic, Michele De Palma, Bijan Modarai
Journal: Circulation (2012)

Introduction Monocytes (CD14+ cells) expressing the angiopoietin receptor, TIE2, are a highly angiogenic subset that are pivotal to neovascularisation in the environs of tumours. We hypothesise tha...
Lack of association with epidermal growth factor receptor gene polymorphisms with clinical outcome in patients with advanced colorectal cancer treated with platinum-based chemotherapy
Authors: D. J. Park, W. Zhang, M. Gordon, D. Y. Yang, R. Ladner, S. Iqbal, S. Groshen, D. Vallbohmer, H. Lenz, W. Fazzone
Journal: Journal of Clinical Oncology (2006)

3079 Background: We had previously shown an association between functional polymorphisms of the epidermal growth factor receptor gene and clinical outcome to platinum-based chemotherapy in advanced colorectal cancer in a retrospective study. Specifically, patients with &lt;20 CA repeats in intron-1 of the EGFR gene were shown to have increased risk of disease progression. Here in, we report our findings of a confirmatory prospective study. Methods: Between September 2001 and August 2004, 173 patients with advanced refractory colorectal cancer were enrolled. Patients received 5-FU 200 mg/m 2 /day as continuous infusion and oxaliplatin 130 mg/m 2 , in three week cycles. Blood samples for genomic analysis were available for 152 patients. EGFR intron 1 CA-repeat and HER1- R497K polymorphisms and their relationship with clinical response, time-to-progression, overall survival, and toxicity, either alone or in combination were assessed prospectively. In addition, we were able to perform quantitative gene expression analysis of EGFR through RT-PCR in a subset of 58 patients. Results: Our cohort of 152 patients comprised 78 males and 74 females, with a median age of 60. There were 105 Caucasians, 24 Asians, 5 Blacks, and 18 Hispanics. The median number of cycles received was 5. The median survival was 10.3 months with a median follow-up of 18.6 months. There were 28 responders (19%). Asians were more likely to possess longer CA repeats and the HER1- 497K variant (Fisher’s exact test p&lt;0.05). Neither EGFR intron-1 CA repeat nor the HER1- R497K polymorphisms were associated with clinical response, time-to-progression, overall survival, toxicity (p&gt;0.10). EGFR gene expression was not associated with clinical outcome (p&gt;0.10). Shorter EGFR intron-1 CA repeats (&lt;20) was associated with higher EGFR gene expression (Kruskal-Wallis t test p=0.013)Conclusion: We were not able to confirm prospectively a previously reported association between functional EGFR gene polymorphisms and clinical outcome to platinum-based therapy in patients with advanced colorectal cancer. In-vitro studies assessing differential oxaliplatin sensitivity with respect to EGFR expression are on-going. [Table: see text]
Radiation-induced breast cancer after treatment for Hodgkin's disease.
Authors: B Cutuli
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.6.2285 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9626236 Radiation-induced breast cancer after treatment for Hodgkin's disease. B CutulixB CutuliSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.6.2285 First Page PDF © 1998 by American Society of Clinical Oncology
Quantity and Quality of Life
Authors: Atul Gawande
Journal: JAMA (2016)

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DNA Replication and Degradation in Mammalian Tissues. V. A Series of Slow-Growing Rat Renal Tumors and a Variety of Human Cancers&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: John Laszlo, M.D., Peter Ove, Ph.D., William W. Shingleton, M.D., Harold P. Morris, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1969)

DNA synthesis, DNA polymerase, thymidine kinase, and deoxyribonuclease were measured in a series of slow-growing, transplantable renal tumors of the rat and compared to normal kidney tissue. DNA synthesis, measured by incorporation of 3H-thymidine in vivo, did not differ significantly in tumors from normal kidney. Thymidine kinase activity of tumor extracts was slightly lower in the renal tumors than in control tissue. The in vitro activity of the tumor DNA polymerase, which prefers denatured DNA primer, was significantly greater than normal, whereas deoxyribonuclease activity was lower than normal kidney. A small series of human tumors (4 colon, 2 breast, and 1 melanoma) also had similar changes in polymerase and nuclease when compared with adjacent normal tissue. Thymidine kinase was slightly elevated in the human colon tumor. These findings are similar to those we previously reported for a series of 12 hepatomas. An inhibitor to deoxyribonuclease is in normal and tumor tissue; evidence is presented to suggest that differences in deoxyribonuclease activity may be explained by difference in inhibitor activity.
Carcinogenesis in Cortisone-Treated Mice Following Vaccinia Dermal Infection and Application of Methyichoianthrene&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn2"&gt;3&lt;/xref&gt;
Journal: JNCI Journal of the National Cancer Institute (1962)