tbuckley/cabot-search huggingface dataset:
P158 The strength of association between the risk of endotracheal intubation and initial arterial blood (ABG) pH in patients presenting with acute hypercapnic respiratory failure (AHRF) treated with non-invasive ventilation (NIV)
Authors: A. Thomas, B. Beauchamp, B. Chakraborty, M. Page, S. Khanum, E. Gallagher, D. Banerjee, R. Mukherjee
Journal: Thorax (2010)

<h3>Introduction</h3> The risk of failure of non-invasive ventilation (NIV) in AHRF patients is greater with higher degrees of acidosis. The BTS guidelines suggest that patients with pH &lt;7.26 have a higher risk of NIV failure which implies a higher risk of endotracheal intubation. <h3>Aims and objectives</h3> We set out to verify the strength of this known association of initial arterial pH (pre-commencement of NIV) and the risk of endotracheal intubation in a large dataset. <h3>Methods</h3> A retrospective analysis of the initial ABG values on 1003 episodes of NIV at a dedicated respiratory NIV unit from 1 August 2004 to 31 December 2009. We predicted the probability of endotracheal intubation (T) using pH, pCO<sub>2</sub> and pO<sub>2</sub> variables, using a logistic regression model. The fitted equation was log [T/(1−T)]=53.0704–7.7064 [pH]–0.0752 [CO<sub>2</sub>]–0.005[O<sub>2</sub>] which was applied to find the strength of association and expressed as p-values. <h3>Results</h3> In 1003 recorded episodes of acute NIV, the data entry was complete in 998 episodes on 712 unique patients. The p-values for the significance in predicting the risk of endotracheal intubation from the initial (pre-NIV) pH, CO<sub>2</sub> and O<sub>2</sub> are 0.0036, 0.3551, and 0.8929 respectively. The summary statistic for initial pH is stated in Abstract P158 Table 1. <h3>Conclusion</h3> Our survey confirms that out of initial pH, pCO<sub>2</sub> and pO<sub>2</sub>, pH is the significant factor (p=0.0036) in predicting the risk of endotracheal intubation of acute hypercapnic respiratory failure patients treated with NIV.
THE DEDICATED DRUG ELUTING BIFURCATION OPTIMIZATION STENT SYSTEM (BIOSS) REGISTRY – FIRST-IN-HUMAN RESULTS
Authors: Dobrin Vassilev, Robert Gil, Aleksanda Michalek, Slawomir Dobrzycki, Radoslaw Formuszewicz, Adam Kern, Tomasz Kulawik, Tomasz Pwlowski
Journal: Journal of the American College of Cardiology (2011)
Cisplatin plus gemcitabine versus paclitaxel plus gemcitabine as first-line therapy for metastatic triple-negative breast cancer (CBCSG006): a randomised, open-label, multicentre, phase 3 trial
Authors: Xi-Chun Hu, Jian Zhang, Bing-He Xu, Li Cai, Joseph Ragaz, Zhong-Hua Wang, Bi-Yun Wang, Yue-E Teng, Zhong-Sheng Tong, Yue-Yin Pan, Yong-Mei Yin, Chang-Ping Wu, Ze-Fei Jiang, Xiao-Jia Wang, Gu-Yin Lou, Dong-Geng Liu, Ji-Feng Feng, Jian-Feng Luo, Kang Sun, Ya-Jia Gu, Jiong Wu, Zhi-Min Shao
Journal: The Lancet Oncology (2015)
Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations
Authors: M Neumann, S Heesch, N Gökbuget, S Schwartz, C Schlee, O Benlasfer, N Farhadi-Sartangi, J Thibaut, T Burmeister, D Hoelzer, W-K Hofmann, E Thiel, C D Baldus
Journal: Blood Cancer Journal (2012)

A subgroup of pediatric acute T-lymphoblastic leukemia (T-ALL) was characterized by a gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly unfavorable outcome. We have investigated clinical and molecular characteristics of the ETP-ALL subgroup in adult T-ALL. As ETP-ALL represents a subgroup of early T-ALL we particularly focused on this cohort and identified 178 adult patients enrolled in the German Acute Lymphoblastic Leukemia Multicenter studies (05/93–07/03). Of these, 32% (57/178) were classified as ETP-ALL based on their characteristic immunophenotype. The outcome of adults with ETP-ALL was poor with an overall survival of only 35% at 10 years, comparable to the inferior outcome of early T-ALL with 38%. The molecular characterization of adult ETP-ALL revealed distinct alterations with overexpression of stem cell-related genes (BAALC, IGFBP7, MN1, WT1). Interestingly, we found a low rate of NOTCH1 mutations and no FBXW7 mutations in adult ETP-ALL. In contrast, FLT3 mutations, rare in the overall cohort of T-ALL, were very frequent and nearly exclusively found in ETP-ALL characterized by a specific immunophenotype. These molecular characteristics provide biologic insights and implications with respect to innovative treatment strategies (for example, tyrosine kinase inhibitors) for this high-risk subgroup of adult ETP-ALL.
SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
Authors: Elena De Falco, Daniele Porcelli, Anna Rita Torella, Stefania Straino, Maria Grazia Iachininoto, Alessia Orlandi, Silvia Truffa, Paolo Biglioli, Monica Napolitano, Maurizio C. Capogrossi, Maurizio Pesce
Journal: Blood (2004)
Long-term results and competing risk analysis of the H89 trial in patients with advanced-stage Hodgkin lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte (GELA)
Authors: Christophe Fermé, Nicolas Mounier, Olivier Casasnovas, Pauline Brice, Marine Divine, Anne Sonet, Fahdela Bouafia, Aspasia Bastard-Stamatoullas, Dominique Bordessoule, Laurent Voillat, Oumedaly Reman, Michel Blanc, Christian Gisselbrecht
Journal: Blood (2006)
Postnatal maturation of excitation-contraction coupling in rat ventricle in relation to the subcellular localization and surface density of 1,4-dihydropyridine and ryanodine receptors.
Authors: M Wibo, G Bravo, T Godfraind
Journal: Circulation Research (1991)

To better understand excitation-contraction coupling in cardiac muscle, we investigated the main Ca2+ channels involved in that process in adult and neonatal rat ventricle. Voltage-dependent (L-type) Ca2+ channels and sarcoplasmic reticulum Ca2+ release channels were labeled by means of [3H] (+)-PN200-110 and [3H]ryanodine, respectively. The number of [3H]ryanodine binding sites (per gram tissue) increased more than that of [3H] (+)-PN200-110 binding sites over the postnatal period (2.1-fold versus 1.35-fold, respectively). After equilibration of microsomal fractions in density gradient, ryanodine receptors were characterized by a heavy distribution pattern that did not change appreciably between days 1 and 30 after birth. In neonatal tissue, 1,4-dihydropyridine receptors were found mainly in low-density subfractions, together with other sarcolemmal constituents, whereas in adult tissue, they were recovered predominantly in high-density subfractions, together with ryanodine receptors. Thus, after birth, and in parallel with the development of T tubules, there was a progressive concentration of L-type Ca2+ channels in junctional structures of high equilibrium density, where they were situated close to the Ca2+ release channels of the sarcoplasmic reticulum. In adult ventricle, L-type channels were, on an average, threefold more abundant in T tubules than in external sarcolemma. In parallel mechanical studies, we found that the inhibitory action of ryanodine on systolic contraction was much more pronounced in adult than in neonatal right ventricle, and that, conversely, neonatal tissue was more sensitive that adult tissue to inhibitors of L-type channels. We conclude that, in view of the presumed mechanism of Ca2+ release from the sarcoplasmic reticulum, that is, Ca(2+)-induced Ca2+ release, the predominant localization in adult rat ventricle of the major Ca2+ entry pathway in the vicinity of the Ca2+ release pathway is of great functional significance. Furthermore, owing to the relative stoichiometry of Ca2+ entry and Ca2+ release channels in junctional structures (about 1:9), a physical link between these channels is not likely to be involved in the modulation of Ca2+ release from the sarcoplasmic reticulum in cardiac muscle.
Response to Comment on: Kan et al. A Systematic Review and Meta-analysis of the Association Between Depression and Insulin Resistance. Diabetes Care 2013;36:480–489
Authors: Carol Kan, Naomi Silva, Sherita Hill Golden, Ulla Rajala, Markku Timonen, Daniel Stahl, Khalida Ismail
Journal: Diabetes Care (2013)

Two key issues are raised by Dr. Kawada (1): assessment of depression and insulin resistance (IR).

The prevalence of depression varied with the method used to identify depression cases, and the author suggested the use of only one standard definition. Diagnostic interview was used in six datasets in the meta-analysis, with two datasets using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) Disorders (SCID) and four using the Composite International Diagnostic Interview (CIDI). The latter is designed for the assessment of mental disorders according to the definitions and criteria of International Classification of Diseases, …
Results of the National Initiative for Cancer Care Quality: How Can We Improve the Quality of Cancer Care in the United States?
Authors: Jennifer L. Malin, Eric C. Schneider, Arnold M. Epstein, John Adams, Ezekiel J. Emanuel, Katherine L. Kahn
Journal: Journal of Clinical Oncology (2006)

In 1999, the National Cancer Policy Board called attention to the quality of cancer care in the United States and recommended establishing a quality monitoring system with the capability of regularly reporting on the quality of care for patients with cancer.Using data from a patient survey 4 years after diagnosis and review of medical records, we determined the percentage of stage I to III breast cancer and stage II to III colorectal cancer survivors in five metropolitan statistical areas (MSAs) across the United States who received recommended care specified by a comprehensive set of explicit quality measures.Two thousand three hundred sixty-six (63%) of 3,775 eligible patients responded to the survey, and 85% consented to have their medical records reviewed. Our final analytic sample (n = 1,765) included 47% of the eligible patients. Patients with breast and colorectal cancer received 86% of recommended care (95% CI, 86% to 87%) and 78% of recommended care (95% CI, 77% to 79%), respectively. Adherence to quality measures was less than 85% for 18 of the 36 breast cancer measures, and significant variation across MSAs was observed for seven quality measures. The percent adherence was less than 85% for 14 of the 25 colorectal cancer measures, and one quality measure demonstrated statistically significant variation across the MSAs.Initial management of patients with breast and colorectal cancer in the United States seemed consistent with evidence-based practice; however, substantial variation in adherence to some quality measures point to significant opportunities for improvement.
"Goalkeeper's hip": acute haematogenous osteomyelitis secondary to apophyseal fractures
Authors: R A Dunsmuir, S J Barnes, G McGarrity
Journal: British Journal of Sports Medicine (2006)

We report two cases of acute haematogenous osteomyelitis in the anterior superior iliac spine (ASIS) in adolescent goalkeepers following trauma of the iliac crest apophysis. Both patients complained of pain over their right ASIS and were pyrexial. They were given antibiotics and were discharged from follow up without complication 64 and 90 days after starting treatment.
The Importance, and Important Limitations, of Ultrasound Imaging for Evaluating Thyroid Nodules
Authors: Erik K. Alexander, David Cooper
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Infants and Interactive Media Use—Reply
Authors: Dimitri A. Christakis
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Determination of the prevalence of bronchial asthma (BA) and development of an effective protocol to detect BA in japanese elite athletes
Authors: M Dohi, Y Komatsu, F Yamasawa, T Akama, K Watanabe, A Hasegawa, M Hirashima, Y Fujita, K Ota, T Kawahara
Journal: British Journal of Sports Medicine (2011)

Background The prevalence of bronchial asthma (BA) including exercise-induced bronchoconstriction (EIB) and airway hyperresponsivenss (AHR) is increasing not only among normal population but also among athletes and prevention of these attacks are just as life saving and crucial for the athlete. The negative impact on athletic performance and the effect of inhaled corticosteroids and ƒÀ2-agonists are factors to providing prevention strategies in these athletes. Objective To determine the prevalence of BA (including silent BA) and develop an effective protocol to detect BA and provide preventive measures in elite athletes. Methods Asthma questionnaires and spirometry were conducted for all regardless of their clinical history. Bronchodilator tests were administered to those who met our criteria of past history, suspicious symptoms, values of FEV1%, and concave shape of flow-volume curves. Bronchial provocation tests were held to detect EIB and AHR in some athletes with suspicious symptom. IOC-criteria were used to consider those tests to be positive. Diagnosis of BA was made by consideration of all factors. Participants 347 male and 305 female Japanese elite athletes participating at the Beijing Olympic Games 2009 and the Vancouver Olympic Games 2010. Main outcome measurements Detecting BA and silent BA is important to prevent BA attacks and begin early intervention strategies in elite athletes in view of their performance and doping violence. Results 21 athletes met IOC criteria in bronchodilator test. The provocation test was positive for asthma in four cases. The prevalence of BA among Japanese elite athletes was 12.1%. Number of Asymptomatic athletes diagnosed as BA reached to 2.9%. Conclusion The prevalence of BA among Japanese elite athletes is similar to prevalence of athletes reported and our protocol can sufficiently detect BA and silent BA as well.
Contralateral Breast Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers
Authors: Monika K. Graeser, Christoph Engel, Kerstin Rhiem, Dorothea Gadzicki, Ulrich Bick, Karin Kast, Ursula G. Froster, Bettina Schlehe, Astrid Bechtold, Norbert Arnold, Sabine Preisler-Adams, Carolin Nestle-Kraemling, Mohammad Zaino, Markus Loeffler, Marion Kiechle, Alfons Meindl, Dominic Varga, Rita K. Schmutzler
Journal: Journal of Clinical Oncology (2009)

Purpose To estimate the risk for contralateral breast cancer in members of BRCA1- and BRCA2-positive families and to determine predictive risk factors. Patients and Methods A retrospective, multicenter, cohort study was performed from 1996 until 2008 and comprised 2,020 women with unilateral breast cancer (index patients, n = 978; relatives, n = 1.42) from 978 families who had a BRCA1 or BRCA2 mutation. Cox regression analysis was applied to assess the association of age at first breast cancer with time from first to contralateral breast cancer, stratified by the affected BRCA gene. Results The cumulative risk for contralateral breast cancer 25 years after first breast cancer was 47.4% (95% CI, 38.8% to 56.0%) for patients from families with BRCA1 or BRCA2 mutations. Members of families with BRCA1 mutations had a 1.6-fold (95% CI, 1.2-fold to 2.3-fold) higher risk of contralateral breast cancer than members of families with BRCA2 mutations. Younger age at first breast cancer was associated with a significantly higher risk of contralateral breast cancer in patients with BRCA1 mutation, and a trend was observed in patients with BRCA2 mutation. After 25 years, 62.9% (95% CI, 50.4% to 75.4%) of patients with BRCA1 mutation who were younger than 40 years of age at first breast cancer developed contralateral breast cancer, compared with only 19.6% (95% CI, 5.3% to 33.9%) of those who were older than 50 years of age at first breast cancer. Conclusion Contralateral breast cancer risk depends on age at first breast cancer and on the affected BRCA gene, and this risk should be considered in treatment planning.
Involvement of LCA5 in Leber Congenital Amaurosis and Retinitis Pigmentosa in the Spanish Population
Authors: Marta Corton, Almudena Avila-Fernandez, Elena Vallespín, María Isabel López-Molina, Berta Almoguera, Esther Martín-Garrido, Sorina D. Tatu, M. Imran Khan, Fiona Blanco-Kelly, Rosa Riveiro-Alvarez, María Brión, Blanca García-Sandoval, Frans P.M. Cremers, Angel Carracedo, Carmen Ayuso
Journal: Ophthalmology (2013)
Tight control and intensified COBRA combination treatment in early rheumatoid arthritis: 90% remission in a pilot trial
Authors: L H D van Tuyl, W F Lems, A E Voskuyl, P J S M Kerstens, P Garnero, B A C Dijkmans, M Boers
Journal: Annals of the Rheumatic Diseases (2008)

<h3>Objective:</h3> To investigate the efficacy and feasibility of an intensive combination treatment in early rheumatoid arthritis (RA) combined with monitoring both disease activity and cartilage degradation. <h3>Methods:</h3> In a pilot trial, 21 patients with active early RA (mean DAS28 5.3; mean disease duration 3 months) were treated with COBRA treatment comprising sulfasalazine, methotrexate and high-dose step-down prednisolone, intensified by adding hydroxychloroquine and continued low-dose prednisolone. In addition, based on measurements of disease activity or a marker of cartilage degradation (CTX-II), treatment adjustments were possible with methotrexate intensification after 8 or 21 weeks; and with infliximab after 21 weeks. <h3>Results:</h3> Nineteen of 21 patients (90%) were in remission (DAS28 &lt;2.6) after 40 weeks (8 weeks, 57%; 21 weeks, 76%). American College of Rheumatology (ACR) criteria, ACR20, 50, 70 and 90 improvements rates were 100%, 95%, 71% and 43% respectively. CTX-II excretion decreased by mean (SD) 347(292) ng/mmol creatinine, but only 50% of patients reduced their CTX-II excretion below the cut-off point. The two monitoring groups showed no significant difference in remission according to DAS score or CTX-II excretion, despite a trend towards more intensive treatment in the CTX-II group. Treatment intensification was feasible according to protocol. <h3>Conclusions:</h3> This small pilot study suggests that intensified and tightly controlled COBRA treatment is uniquely effective in early RA. <h3>Trial registration number:</h3> ISRCTN96372677.
Neuroanatomical Correlates of Religiosity and Spirituality
Authors: Lisa Miller, Ravi Bansal, Priya Wickramaratne, Xuejun Hao, Craig E. Tenke, Myrna M. Weissman, Bradley S. Peterson
Journal: JAMA Psychiatry (2013)

We previously reported a 90% decreased risk in major depression, assessed prospectively, in adult offspring of depressed probands who reported that religion or spirituality was highly important to them. Frequency of church attendance was not significantly related to depression risk. Our previous brain imaging findings in adult offspring in these high-risk families also revealed large expanses of cortical thinning across the lateral surface of the right cerebral hemisphere.To determine whether high-risk adults who reported high importance of religion or spirituality had thicker cortices than those who reported moderate or low importance of religion or spirituality and whether this effect varied by family risk status.Longitudinal, retrospective cohort, familial study of 103 adults (aged 18-54 years) who were the second- or third-generation offspring of depressed (high familial risk) or nondepressed (low familiar risk) probands (first generation). Religious or spiritual importance and church attendance were assessed at 2 time points during 5 years, and cortical thickness was measured on anatomical images of the brain acquired with magnetic resonance imaging at the second time point.Cortical thickness in the parietal regions by risk status.Importance of religion or spirituality, but not frequency of attendance, was associated with thicker cortices in the left and right parietal and occipital regions, the mesial frontal lobe of the right hemisphere, and the cuneus and precuneus in the left hemisphere, independent of familial risk. In addition, the effects of importance on cortical thickness were significantly stronger in the high-risk than in the low-risk group, particularly along the mesial wall of the left hemisphere, in the same region where we previously reported a significant thinner cortex associated with a familial risk of developing depressive illness. We note that these findings are correlational and therefore do not prove a causal association between importance and cortical thickness.A thicker cortex associated with a high importance of religion or spirituality may confer resilience to the development of depressive illness in individuals at high familial risk for major depression, possibly by expanding a cortical reserve that counters to some extent the vulnerability that cortical thinning poses for developing familial depressive illness.