Genomics: Prediction, Prevention, Priorities, and Punnett
Authors: Michael F. Murray
Journal: Annals of Internal Medicine (2016)

Editorials2 February 2016Genomics: Prediction, Prevention, Priorities, and PunnettMichael F. Murray, MDMichael F. Murray, MDFrom Geisinger Health System, Forty Fort, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-2993 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Two genomics questions face us in health care: What DNA sequence–based results should be delivered to healthy adults, and what happens when we deliver these results?Until recently, the question of “what to deliver” would have been correctly judged irrelevant by most practicing clinicians because of the cost of generating the results and their limited predictive value. However, in addition to other advances, we are now poised to enroll more than 1 million Americans in a Precision Medicine Initiative, and “what to deliver” will be a very practical question (1). Thus, we have reached the day when we must consider ...References1. Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372:793-5. [PMID: 25635347] doi:10.1056/NEJMp1500523 CrossrefMedlineGoogle Scholar2. Christensen KD, Roberts JS, Whitehouse PJ, Royal CDM, Obisesan TO, Cupples LA, et al. Disclosing pleiotropic effects during genetic risk assessment for Alzheimer disease. A randomized trial. Ann Intern Med. 2016;164:155-63. doi:10.7326/M15-0187 LinkGoogle Scholar3. Song Y, Stampfer MJ, Liu S. Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Ann Intern Med. 2004;141:137-47. [PMID: 15262670]. doi:10.7326/0003-4819-141-2-200407200-00013 LinkGoogle Scholar4. Bennet AM, Di Angelantonio E, Ye Z, Wensley F, Dahlin A, Ahlbom A, et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA. 2007;298:1300-11. [PMID: 17878422] CrossrefMedlineGoogle Scholar5. Mosca S, Gargiulo P, Balato N, Di Costanzo L, Parente A, Paolillo S, et al. Ischemic cardiovascular involvement in psoriasis: a systematic review. Int J Cardiol. 2015;178:191-9. [PMID: 25464252] doi:10.1016/j.ijcard.2014.10.092 CrossrefMedlineGoogle Scholar6. Edwards AW. Reginald Crundall Punnett: first Arthur Balfour Professor of Genetics, Cambridge, 1912. Genetics. 2012;192:3-13. [PMID: 22964834] doi:10.1534/genetics.112.143552 CrossrefMedlineGoogle Scholar7. Ball MP, Bobe JR, Chou MF, Clegg T, Estep PW, Lunshof JE, et al. Harvard Personal Genome Project: lessons from participatory public research. Genome Med. 2014;6:10. [PMID: 24713084] doi:10.1186/gm527 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Geisinger Health System, Forty Fort, Pennsylvania.Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-2993.Corresponding Author: Michael F. Murray, MD, Genomic Medicine Institute, Geisinger Health System, 190 Welles Street, Suite 128, Forty Fort, PA 18704; e-mail, [email protected]edu.This article was published at www.annals.org on 26 January 2016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDisclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease Kurt D. Christensen , J. Scott Roberts , Peter J. Whitehouse , Charmaine D.M. Royal , Thomas O. Obisesan , L. Adrienne Cupples , Jacqueline A. Vernarelli , Deepak L. Bhatt , Erin Linnenbringer , Melissa B. Butson , Grace-Ann Fasaye , Wendy R. Uhlmann , Susan Hiraki , Na Wang , Robert Cook-Deegan , Robert C. Green , and Metrics 2 February 2016Volume 164, Issue 3Page: 197-198KeywordsAlzheimer diseaseDisclosureFallsGenomicsHealth careHealth information technologyPrevention, policy, and public healthPsoriasisRisk managementStable coronary artery disease ePublished: 26 January 2016 Issue Published: 2 February 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...