tbuckley/cabot-search huggingface dataset:
Current Concepts in the Evaluation and Treatment of Patients With Diffuse Malignant Peritoneal Mesothelioma
Authors: Keli Turner, Sheelu Varghese, H. Richard Alexander
Journal: Journal of the National Comprehensive Cancer Network (2012)

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare and ultimately fatal cancer that was first recognized and described a century ago. It is a diffuse primary malignant condition arising from the mesothelial lining of the peritoneum, and its natural history is hallmarked by a propensity to progress almost exclusively within the abdominal cavity throughout the entire course of disease. Patients afflicted with DMPM most commonly present with nonspecific abdominal symptoms that lead to diagnosis when the condition is relatively advanced. Historically, median overall survival for patients with DMPM without treatment is very short, averaging 6 months. Systemic chemotherapy using pemetrexed and cisplatin has an overall response rate of approximately 25% and a median overall survival of approximately 1 year. Many institutional reports have shown that in selected patients, operative cytoreduction and hyperthermic intraoperative peritoneal chemotherapy using cisplatin or mitomycin C is associated with long-term survival. Recent studies on the molecular biology of DMPM have yielded new insights relating to the potentially important role of the phosphatidylinositol 3-kinase/mammalian target of rapamycin and epidermal growth factor receptor pathways in this disease, which may translate into new therapeutic options for patients with DMPM.
Use of a monoclonal antibody (GA3) to demonstrate lineage restricted O- glycosylation on leukosialin during terminal erythroid differentiation
Authors: A Bettaieb, F Farace, MT Mitjavila, Z Mishal, MC Dokhelar, T Tursz, J Breton- Gorius, W Vainchenker, N Kieffer
Journal: Blood (1988)
Family interactions within incest and nonincest families
Authors: P G Madonna, S Van Scoyk, D P Jones
Journal: American Journal of Psychiatry (1991)

The study addressed the questions, What are the interactional patterns in families in which incest occurs? and Do these patterns differ from those of families with other clinical problems?The families for the study were chosen from two outpatient clinics; the C. Henry Kempe, National Center for the Prevention and Treatment of Child Abuse and Neglect provided access to families with incest, and the nonincest families each had a child seen in a university child psychiatry clinic. In each of these settings, 30 families were selected in the order of referral for evaluation. All families agreed to participate. Each family was given two tasks to perform during a structured interview. The interviews were videotaped, and 15-20-minute segments were rated independently by two of the authors, who used the Beavers-Timberlawn Family Evaluation Scale to assess interactional behaviors within each family.The incest families were significantly more dysfunctional in all but one area of family interaction. The distribution of power within a family did not differentiate the two types of families.The incest families dysfunctional patterns that seemed to support and maintain the incestuous behavior were a rigid family belief system, a dysfunctional parental coalition, parental neglect and emotional unavailability, and the inability to nurture autonomy in family members.
Cell type–specific manipulation with GFP-dependent Cre recombinase
Authors: Jonathan C Y Tang, Stephanie Rudolph, Onkar S Dhande, Victoria E Abraira, Seungwon Choi, Sylvain W Lapan, Iain R Drew, Eugene Drokhlyansky, Andrew D Huberman, Wade G Regehr, Constance L Cepko
Journal: Nature Neuroscience (2015)
Abstract #4438: Regulation of the bi-directional promoter of human BRCA2/ZAR2 genes by folate-dependent DNA methylation
Authors: Smita Misra, Gautam Chaudhuri
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Human BRCA2 gene expression is tightly regulated. The level of BRCA2 protein in the cell must commensurate with the need of the cells to avoid detrimental consequences in cellular physiology. Here we provide evidence that BRCA2 gene promoter has bi-directional activity, transcribing BRCA2 and a novel ZAR1 -like gene (we named ZAR2 ). The reverse activity of the BRCA2 gene promoter is 7-9 folds higher than the forward activity in the G0/G1 phase of breast cells and is down regulated in the S/G2 phase. ZAR2 protein is predominantly located in the nucleus at the G0/G1 phase but stays in the cytoplasm at the S/G2 phase of the cells. BRCA2/ZAR2 gene bi-directional promoter is regulated by CpG methylation and consequently by folate limitations in the cell. Since folate is involved in in vivo DNA methylation process, we created folate deficiency by ablating the expression of folate transporter hRFC1. DNA immuno- precipitation analysis data revealed hypomethylation of CpG units at the BRCA2/ZAR2 promoter in folate deficiency. ChIP analysis revealed a decrease in the recruitment of HDAC1 and increased acetylations of histone H3 and H4 at the BRCA2/ZAR2 promoter DNA as a consequence of hypomethylation of its CpG units. These data suggest that CpG methylation of BRCA2/ZAR2 promoter DNA, assisted by folate, regulates the expressions of BRCA2/ZAR2 in human breast cells by chromatin remodeling. Supported by the DOD-CDMRP IDEA Grant# W81XWH-06-1-0466 and the Susan G. Komen Breast Cancer Foundation grant# BCTR0707627 to GC.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 4438.
Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts
Authors: Ming Ding, Ambika Satija, Shilpa N. Bhupathiraju, Yang Hu, Qi Sun, Jiali Han, Esther Lopez-Garcia, Walter Willett, Rob M. van Dam, Frank B. Hu
Journal: Circulation (2015)

The association between consumption of caffeinated and decaffeinated coffee and risk of mortality remains inconclusive.We examined the associations of consumption of total, caffeinated, and decaffeinated coffee with risk of subsequent total and cause-specific mortality among 74,890 women in the Nurses' Health Study (NHS), 93,054 women in the Nurses' Health Study II, and 40,557 men in the Health Professionals Follow-up Study. Coffee consumption was assessed at baseline using a semiquantitative food frequency questionnaire. During 4,690,072 person-years of follow-up, 19,524 women and 12,432 men died. Consumption of total, caffeinated, and decaffeinated coffee were nonlinearly associated with mortality. Compared with nondrinkers, coffee consumption of 1 to 5 cups per day was associated with lower risk of mortality, whereas coffee consumption of more than 5 cups per day was not associated with risk of mortality. However, when restricting to never smokers compared with nondrinkers, the hazard ratios (and 95% confidence intervals) of mortality were 0.94 (0.89-0.99) for 1.0 or less cup per day, 0.92 (0.87-0.97) for 1.1 to 3.0 cups per day, 0.85 (0.79-0.92) for 3.1 to 5.0 cup per day, and 0.88 (0.78-0.99) for more than 5.0 cup per day (P value for nonlinearity = 0.32; P value for trend < 0.001). Significant inverse associations were observed for caffeinated (P value for trend < 0.001) and decaffeinated coffee (P value for trend = 0.022). Significant inverse associations were observed between coffee consumption and deaths attributed to cardiovascular disease, neurologic diseases, and suicide. No significant association between coffee consumption and total cancer mortality was found.Higher consumption of total coffee, caffeinated coffee, and decaffeinated coffee was associated with lower risk of total mortality.
Report on 151 Childhood Malignancies Observed in Jamaica
Authors: G. Bras, H. Cole, A. Ashmeade-Dyer, D. C. Watler
Journal: JNCI Journal of the National Cancer Institute (1969)

During a 10-year period 1958–67, 151 tumors were noted in children under 15 years of age in Jamaica. They comprised 2.9% of all malignant tumors observed. Leukemia was the most common form of cancer. The incidence of retinoblastomas was high and surpassed incidences of neuroblastomas and of Wilms' tumors. Kaposi's sarcoma was not observed, and hepatocellular carcinoma was extremely rare. The tumor incidence pattern in Jamica therefore largely resembles that in the United States and in Western Europe. It contrasts significantly with that in Uganda and in Western Nigeria. This merits attention, since over 90% of the Jamaican population is either pure Negro or of predominantly Negro descent as a result of importation from West Africa in former days.
Why Psychiatry Needs Data Science and Data Science Needs Psychiatry
Authors: John Torous, Justin T. Baker
Journal: JAMA Psychiatry (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
M200 (volociximab), a chimeric antibody against integrin alpha5 beta1, inhibits tumor growth by multiple mechanisms
Authors: Vinay Bhaskar, Pauline Wales, Danna Breinberg, Eric Ibsen, Melvin Fox, Yuni Fang, Chris O’hara, Melanie Wong, Robert Dubridge, Richard Murray, Debbie Law, Vanitha Ramakrishnan
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

4497 

Interactions between cells and extracellular matrix (ECM) proteins in the tumor microenvironment are mediated by heterodimeric integrins. One such integrin, alpha5 beta1, mediates adhesion and migration towards fibronectin via a highly conserved RGD sequence. We have found, through immunohistochemical analysis of human tumor tissue, that integrin alpha5 beta1 is highly expressed on the surface of tumor epithelial cells, as well as endothelial cells that make up the invading neovasculature. In vitro , a high-affinity function-blocking antibody against alpha5 beta1, M200, was found to inhibit the proliferation of human endothelial cells by a mechanism that involves cell death. A significant proportion of cancer cell lines tested retained a high level of surface alpha5 beta1 in vitro . In proliferation assays, a subset of these cell lines was particularly sensitive to M200. In affected cell lines, M200 was found to inhibit proliferation on fibronectin, as well as other ECM proteins, even when added 24 hours after plating. The effects on proliferation were due, at least in part, to the ability of M200 to induce cell death in these cell lines. M200 cross-reacts with rabbit, but not rodent, alpha5 beta1, therefore, a rabbit neovascularization model was chosen to evaluate the potency of M200 in vivo . M200 was found to exert a statistically significant effect in inhibiting angiogenesis in this setting. We are currently assessing possible anti-tumor effects using the rabbit VX2 carcinoma model. These data suggest that M200 inhibits tumor growth by targeting cancer cells directly, in addition to endothelial cells in the tumor neovasculature.
Abstract 15366: Increased Endothelial Expression of NADPH Oxidase-p47phox in Human Hypertension
Authors: E. B Solow, Shahab M Danesh, Erica Onwuegbuchu, Alejandro Velasco, Prafull Raheja, Debbie Arbique, Zhongyun Wang, Angela L Price, Chieko Mineo, Wanpen Vongpatanasin
Journal: Circulation (2014)

Introduction:  Hypertensive patients have impaired endothelial-dependent vasodilation. Endothelial nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p47 subunit (p47phox) may contribute to hypertension (HTN) via generation of reactive oxygen species. NADPH oxidase derived superoxide has been shown to inactivate nitric oxide, a potent vasodilator produced by endothelial nitric oxide synthase (eNOS) in endothelial cells (EC), causing endothelial dysfunction. EC expression of p47phox and eNOS in human HTN has not been previously assessed.   Methods:  We assessed endothelial function in 20 Stage 1 hypertensive subjects (mean age 50 years, 55% female) and 18 normotensive (NT) controls (mean age 47 years, 68% female) by brachial artery flow mediated dilation (FMD) and extracted venous EC by J-wires via forearm catheters. Expression of p47phox, eNOS, and phosphorylated eNOS at serine 1177 residue (peNOS) was captured by immunofluorescence microscopy using human umbilical vein endothelial cell (HUVEC) controls.   Results:  FMD was lower in hypertensive compared to NT subjects (6.3±0.6 versus 8.5±1.0 %, p    Conclusions:  We found impaired endothelial function and enhanced EC expression of NADPH oxidase p47 subunit, the major oxidant enzyme responsible for vascular superoxide formation, in human hypertension.
Striatal Dopamine Links Gastrointestinal Rerouting to Altered Sweet Appetite
Authors: Wenfei Han, Luis A. Tellez, Jingjing Niu, Sara Medina, Tatiana L. Ferreira, Xiaobing Zhang, Jiansheng Su, Jenny Tong, Gary J. Schwartz, Anthony van den Pol, Ivan E. de Araujo
Journal: Cell Metabolism (2015)
Predictors of success in smoking cessation among Brazilian subjects
Authors: Rafaella Xavier, Dionei Ramos, Fernanda Rodrigues, Marceli Leite, Juliana Ito, Camila Suehiro, Pedro Cerqueira, Alessandra Toledo, Ercy Ramos
Journal: European Respiratory Journal (2012)

The predictors of success or failure in smoking cessation programme (SCP), specific for the Brazilian population have been low studied.We evaluated characteristics influencing the success in a SCP. This non-randomized, prospective and open clinical trial evaluated 172 smokers attended in a SCP based on cognitive behavioral treatment associated or not with medication therapy. Individuals were followed for 12 months. Statiscal analysis was performed using the R statistical software. For quantitative variables (age, pack years index and cigarettes/day) were used t-tests and for qualitative variables (gender, education level, lived with others smokers, medication therapy, nicotine dependence, socioeconomic, anxiety and depression level.) were used χ2 test. The influence of epidemiologic characteristics on smoking cessation (SC) in univariate and multivariate analyses was tested, calculating Relative Risks (RR) with confidence intervals of 95% (CI). Variables resulting in P0.15 for univariate analysis were selected to enter into logistic regression model. Differences were considered significant at P0.05. Results: 172 individuals were included, 126 (73%) started treatment, of which 61 individuals (48%) started abstinent and according the logistic model the individuals who used medication therapy had eight-fold more chances to started abstinence (P=0.0002 RR=8 CI 3-29). Thirty-three percente of individuals remained abstinent for 12 months and smokers with lower socioeconomic level had nine-fold more chances to return to smoking (P=0.005 RR=9 CI 2-57). Conclusions: The success rate of this program was 16% and medication, as well as socioeconomic status are predictors of success in SC.
Internet-Delivered Psychological Treatments
Authors: Gerhard Andersson
Journal: Annual Review of Clinical Psychology (2015)

During the past 15 years, much progress has been made in developing and testing Internet-delivered psychological treatments. In particular, therapist-guided Internet treatments have been found to be effective for a wide range of psychiatric and somatic conditions in well over 100 controlled trials. These treatments require (a) a secure web platform, (b) robust assessment procedures, (c) treatment contents that can be text based or offered in other formats, and (d) a therapist role that differs from that in face-to-face therapy. Studies suggest that guided Internet treatments can be as effective as face-to-face treatments, lead to sustained improvements, work in clinically representative conditions, and probably are cost-effective. Despite these research findings, Internet treatment is not yet disseminated in most places, and clinical psychologists should consider using modern information technology and evidence-based treatment programs as a complement to their other services, even though there will always be clients for whom face-to-face treatment is the best option.
P1343 : Phase I dose-escalation study evaluating the safety and pharmacokinetics of oral artesunate in patients with advanced hepatocellular carcinoma (desparth trial)
Authors: Y.-P. Vandewynckel, K. Rombauts, X. Verhelst, L. Van Bortel, B. De Spiegeleer, A. Geerts, H. Van Vlierberghe
Journal: Journal of Hepatology (2015)
The INPULSIS trials of idiopathic pulmonary fibrosis treatment: explaining further discrepancies on exacerbations
Authors: Samy Suissa, Pierre Ernst
Journal: European Respiratory Journal (2015)

In a recent paper on the INPULSIS trials, two duplicate 1-year randomised controlled trials evaluating nintedanib in the treatment of idiopathic pulmonary fibrosis (IPF) [1], we provided the methodological explanation for the apparent inconsistent results arising from the two different definitions of exacerbations used in those studies [2]. These trials reported vastly different findings in their pooled analysis [1]. Indeed, the risk of an investigator-reported acute exacerbation was lower by 36% with nintedanib compared with placebo but not statistically significant (p=0.08), while, after adjudication according to a complex definition involving multiple criteria, the risk was lower by 68% and statistically significant (p=0.001). We explained that such differences in risk reductions and in statistical significance are simply the result of including outcome events that are not actual exacerbations, leading to the phenomenon of treatment effect dilution and false nonsignificant effects [2]. The correct risk reduction of 68% based on the accurate adjudicated events is diluted to a less impressive and now nonsignificant risk reduction of 36% when "false" events were added in the same proportion to both groups. Adjudication of acute exacerbations of IPF in clinical trials is crucial for accurate treatment effectiveness <http://ow.ly/U2i35>
Abstract P219: Constant Numbers but Change in Stroke Subtype of Patients with First-Ever Minor Stroke/TIA from 2002 to 2012 in London, Canada
Authors: Chrysi Bogiatzi, Daniel G Hackam, Ian A McLeod, David J Spence
Journal: Circulation (2014)

Introduction: In Canada, major stroke hospital admission decreased by 27.6% and stroke mortality decreased by 28.2% between 1994 and 2004. However, there are no regional data on rates of incident minor stroke/TIA. We hypothesized that there has been a decrease in minor stroke/TIA over time due to better management of cerebrovascular risk factors. Methods: We included patients who diagnosed with a minor stroke/TIA in the regional Urgent TIA Clinic in London, Ontario, Canada from 2002 to 2012. We used a valid and reliable classification system for subtypes of ischemic stroke (SPARKLE) to categorize patients into five etiological stroke subtypes. Secular trends of minor stroke/TIA and the five ischemic stroke subtypes, represented with Lattice Plots, were analyzed using Poisson regression analysis with spline trend function. Results: Between 2002 and 2012, we identified 3,445 eligible patients. There was no decrease in minor stroke/TIA during the study period (348 patients in 2002 versus 261 patients in 2012, p=0.65 for trend). However, there was a significant increase in cardioembolic stroke/TIA, with a corresponding decrease in all other ischemic stroke subtypes. Patients in 2012 were one year younger compared to patients in 2002 (p=0.04). Discussion: Stroke mortality and major stroke incidence have decreased over time, but numbers of patients who experience a first-ever minor stroke/TIA have remained constant. With more intensive medical therapy there may have been a shift from major to minor stroke occurrence, given that more recent patients are younger than patients presenting in previous years. Further investigation is required to identify prevailing stroke risk factors in this population to decrease the burden and incidence of stroke/TIA.
Immunosuppressive effects of pentostatin.
Authors: E H Kraut, J C Neff, B A Bouroncle, D Gochnour, M R Grever
Journal: Journal of Clinical Oncology (1990)

The immune function of patients with hairy cell leukemia (HCL) and solid tumors was evaluated before and after treatment with the investigational drug 2'-deoxycoformycin (pentostatin; dCF). Thirteen HCL patients received doses of dCF of 2 to 4 mg/m2 intravenously at 2- to 6-week intervals for up to 15 courses. After completion of treatment, 12 of 13 patients had resolution of severe monocytopenia and five of nine had normal monocyte antibody dependent cellular cytotoxicity. There was statistically significant depression of total lymphocytes, T cells, and B cells. Evaluation of T subsets showed a decrease in CD4+ cells. Immunoglobulin G (IgG) in sera were decreased from baseline, while IgM and IgA were unaffected. There was no significant effect on skin-test reactivity or large granular lymphocyte numbers. Lymphoblastic transformation was variably affected. Natural-killer (NK) cell function was improved or unchanged after dCF treatment. Reevaluation of seven patients at 21 to 119 weeks after receiving dCF demonstrated that recovery to normal T- and B-cell numbers and subsets does occur. Five solid tumor patients were given dCF at 4 mg/m2 intravenously at 1- to 2-week intervals for up to five courses. There was significant reduction in T cells, B cells, CD4+, and CD8+ cells with no statistically significant effect on the other immune parameters. We conclude that low doses of dCF can cause persistent immunosuppression though recovery may occur after the drug is stopped. In patients followed after completion of dCF, there was no associated increase in second malignancies or unusual infections.
Barriers to access to opioid medicines: a review of national legislation and regulations of 11 central and eastern European countries
Authors: Marjolein J M Vranken, John A Lisman, Aukje K Mantel-Teeuwisse, Saskia Jünger, Willem Scholten, Lukas Radbruch, Sheila Payne, Marie-Hélène D B Schutjens
Journal: The Lancet Oncology (2015)
PRENATAL INFESTATION WITH PARASITIC WORMS
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal