tbuckley/cabot-search huggingface dataset:
Endoscopic ultrasonography of solitary rectal ulcer syndrome
Authors: Malay Sharma, Piyush Somani, Amol Patil, Avinash Kumar, Charu Shastri
Journal: Endoscopy (2016)

Solitary rectal ulcer syndrome (SRUS) is an uncommon poorly understood benign disorder of defecation. SRUS may simulate other disorders such as inflammatory bowel disease and neoplasms. Histopathological analysis forms the cornerstone of diagnosis for SRUS. Key histological features include fibromuscular obliteration of the lamina propria with splaying of the muscularis mucosae upward between the crypts, thickened mucosa, and glandular distortion [1].
Effect of TRA-8 anti-DR5 monoclonal antibody in combination with chemotherapy in an <i>ex vivo</i> human ovarian cancer model
Authors: P. J. Frederick, J. E. Kendrick, J. M. Straughn, P. G. Oliver, H. Lin, D. L. Della Manna, A. F. LoBuglio, D. J. Buchsbaum
Journal: Journal of Clinical Oncology (2008)

14695 Background: It has been previously demonstrated that TRA-8 anti-DR5 monoclonal antibody induces apoptosis in primary human ovarian cancer (Gynecol Oncol 105:291–298, 2007). The purpose of this study was to evaluate the cytotoxicity of TRA-8 in combination with carboplatin and paclitaxel utilizing the same ex vivo three-dimensional tissue slice technique. Methods: Primary epithelial ovarian cancer tissue from 18 patients was obtained at the time of cytoreductive surgery. The Krumdieck tissue slicer was used to prepare 5 mm slices. 300 μm thick slices were incubated in media and treated with TRA-8, carboplatin, paclitaxel, or a combination of TRA-8 plus carboplatin and paclitaxel for 24–48 hours. To evaluate cytotoxicity, ATP levels were assessed using a luminescence-based ATP assay and compared to untreated control slices. Results: The average patient age was 63 years-old (range 48–84). Fourteen patients (78%) were Caucasian and 4 (22%) were African American. Sixteen (89%) tumor specimens were papillary serous and 2 (11%) were endometrioid histology. Ten specimens were treated with carboplatin and paclitaxel alone. A dose-response curve was demonstrated in 8 of 10 specimens. Eight specimens were treated with TRA-8 plus carboplatin and paclitaxel. Increased cytotoxicity with TRA-8 compared to chemotherapy alone was observed in 6 of 8 specimens. Specimens treated with 100 ng/mL of TRA-8 alone demonstrated 22% mean cytotoxicity. Specimens treated with carboplatin and paclitaxel showed 33% mean cytotoxicity. In specimens treated with carboplatin, paclitaxel, and TRA-8, mean cytotoxicity was 70%. The difference between TRA-8 plus chemotherapy and chemotherapy alone (p = 0.013), and the difference between TRA-8 plus chemotherapy and TRA-8 alone (p = 0.006) was significant. Conclusions: These data indicate that the combination of TRA-8 and chemotherapy results in more cytotoxicity in an ovarian cancer model than either treatment alone. The use of death receptor monoclonal antibodies such as TRA-8 may serve as a valuable adjuvant therapy for patients with ovarian cancer. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Daiichi Sankyo, Inc.
Abstract 17620: Paracrine Actions of the Intracellular Second Messenger cAMP Secreted From Cardiac Myocytes
Authors: Yassine Sassi, Jeffery Truong, Andrea Ahles, Anne-Marie Lompre, Jean-Sebastien Hulot, Christa Muller, Andreas Dendorfer, Bernhard Laggerbauer, Stefan Engelhardt
Journal: Circulation (2013)

Acute stimulation of cardiac β-adrenergic receptors and the resultant modulation of cyclic adenosine monophosphate (cAMP) signalling are crucial to increase cardiac function under stress. Yet, cont...
Mammalian Sarcoma-Leukemia Viruses. I. Infection of Feline, Bovine, and Human Cell Cultures With Snyder-Theilen Feline Sarcoma Virus
Authors: Emerson W. Chan, Pauline E. Schiop-Stansly, Timothy E. O'Connor
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Mammalian Sarcoma-Leukemia Viruses. I. Infection of Feline, Bovine, and Human Cell Cultures With Snyder-Theilen Feline Sarcoma Virus Get access Emerson W. Chan, Emerson W. Chan Search for other works by this author on: Oxford Academic PubMed Google Scholar Pauline E. Schiop-Stansly, Pauline E. Schiop-Stansly Search for other works by this author on: Oxford Academic PubMed Google Scholar Timothy E. O'Connor Timothy E. O'Connor Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 2, February 1974, Pages 473–481, https://doi.org/10.1093/jnci/52.2.473 Published: 01 February 1974 Article history Received: 06 August 1973 Accepted: 19 October 1973 Published: 01 February 1974
Abstract P068: Dietary Acculturation in Two Ethnic Populations Has a Differential Impact on Diet Quality
Authors: Kathleen Abu-Saad, Havi Murad, Flora Lubin, Arnona Ziv, Laurence S Freedman, Gershon Alpert, Ahmed Atamna, Ofra Kalter-Leibovici
Journal: Circulation (2012)

Introduction: The indigenous Arab minority population in Israel has higher rates of cardiovascular morbidity and mortality than the Jewish immigrant population. Differences in dietary intake may underlie some of these health disparities. We tested the hypothesis that dietary patterns differ by ethnicity. Methods: A population-based, random sample (n=1,100) was selected, stratified by sex, ethnicity, and age (25–74 years). A food frequency questionnaire with 240 food items, including ethnic foods, was used to assess dietary intake and dietary change during adulthood. Food items were collapsed into 51 groups and entered into principle component analysis to identify dietary patterns. Multivariate regression models were fitted to assess the association between participant characteristics and the dietary patterns. Results: Of 4 dietary patterns identified (Traditional Arabic, Healthy, Animal Protein, and Snack/Fast Food), the Traditional Arabic and Healthy patterns were the most dominant. The Traditional Arabic pattern included high intakes of “Mediterranean diet” components (e.g., olive oil, dairy products, whole grains, legumes, vegetables), as well as less healthy foods (e.g., refined-flour pita bread, meat dishes). Participants with a low score on this pattern had a high intake of starchy, high-fat, and sweet foods. The highest and lowest intake tertiles of this pattern were virtually mono-ethnic (98% Arab, and 98% Jewish, respectively), while the middle tertile was ethnically mixed. Arabs in the middle/lowest tertiles were younger (OR for 10y age increment: 0.71, 95% CI: 0.59–0.84), male (OR: 2.01, 95% CI: 1.38–2.95), and had made non-health related dietary change (OR: 2.40, 95% CI: 1.53–3.77). In contrast, Jews in the middle/highest tertiles had made health-related dietary change (OR: 2.06, 95% CI: 1.27–3.36). The Healthy pattern included a high intake of foods typically found in healthy Western dietary patterns (e.g., vegetables, fruit, low-fat dairy products, whole grains). Arabs had lower odds than Jews of being in the top tertile of the Healthy pattern among never-smokers (OR: 0.12, 95% CI: 0.07–0.21) and current smokers (OR: 0.16, 95% CI: 0.07–0.37); however the strength of this association diminished among past smokers (OR: 0.45, 95% CI: 0.20–1.04). Conclusions: Jews are more likely than Arabs to have classic Western healthy eating patterns, and those who have undergone some dietary acculturation have done so for health-related reasons. The indigenous Mediterranean-style diet of Arabs has deteriorated, and adoption of foods of the immigrant population did not improve the health properties of their diet. These dietary characteristics may place Arabs at higher risk for cardiovascular morbidity and mortality.
Dengue and Dengue Hemorrhagic Fever in the Americas, 1986
Authors: D J Gubler
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer in Kyadondo County, Uganda, 1968–70
Authors: A. C. Templeton, Elizabeth Buxton, Alexis Bianchi
Journal: JNCI Journal of the National Cancer Institute (1972)

A cancer incidence study in Kyadondo County, Uganda, from 1968–70 was compared with a survey of the same area from 1954–60. Overall cancer registration was about 40% higher because of better medical facilities and greater sophistication of the population. The increase in registration among females was greater than among males. The overall pattern of cancer was similar to that reported previously, with 2 exceptions: The incidence of carcinoma of the esophagus increased markedly, particularly among women. The incidence of carcinoma of the penis declined and was not as common in Kyadondo County as in the less sophisticated surrounding areas. Other minor changes probably resulted from social and medical influences on registration practice rather than from a true change in incidence.
Drug survival for azathioprine and enteric‐coated mycophenolate sodium in a long‐term daily practice cohort of adult patients with atopic dermatitis
Authors: J. Schaft, K. Politiek, J.M.P.A. Reek, W. Kievit, E.M.G.J. Jong, C.A.F.M. Bruijnzeel‐Koomen, M.L.A. Schuttelaar, M.S. Bruin‐Weller
Journal: British Journal of Dermatology (2016)

Results from clinical studies indicate that azathioprine and enteric-coated mycophenolate sodium (EC-MPS) are safe and potent drugs in the treatment of atopic dermatitis (AD).(1-5) However, published data from large groups of non-selected patients is non-existent to date which hampers generalization to daily practice. In addition, head-to-head trials in which azathioprine and EC-MPS are compared, have never been performed. The primary objective was to perform an analysis of drug survival for azathioprine and EC-MPS in a long-term daily practice cohort of patients with AD. The secondary objective was to identify determinants of drug survival. This article is protected by copyright. All rights reserved.
Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial
Authors: Mina C Hosseinipour, Gregory P Bisson, Sachiko Miyahara, Xin Sun, Agnes Moses, Cynthia Riviere, Fredrick K Kirui, Sharlaa Badal-Faesen, David Lagat, Mulinda Nyirenda, Kogieleum Naidoo, James Hakim, Peter Mugyenyi, German Henostroza, Paul D Leger, Javier R Lama, Lerato Mohapi, Jorge Alave, Vidya Mave, Valdilea G Veloso, Sandy Pillay, Nagalingeswaran Kumarasamy, Jing Bao, Evelyn Hogg, Lynne Jones, Andrew Zolopa, Johnstone Kumwenda, Amita Gupta
Journal: The Lancet (2016)
The problem of accessing psychotherapies for depression in the UK
Authors: Heather Goodare
Journal: BMJ (2016)

The study by Amick and colleagues confirms what many of us have been saying for decades, that talking therapy is as good as antidepressants for treating depression,1 2 and some would say, often better, and without side effects. Never mind that the research looks at cognitive behavioural therapy (CBT) only, which although helpful in some contexts tends to concentrate on the …
Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines
Authors: Andrew Veitch, Geoffroy Vanbiervliet, Anthony Gershlick, Christian Boustiere, Trevor Baglin, Lesley-Ann Smith, Franco Radaelli, Evelyn Knight, Ian Gralnek, Cesare Hassan, Jean-Marc Dumonceau
Journal: Endoscopy (2017)

Correction to: Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelinesEndoscopy 2016; 48(04): 385-402DOI: 10.1055/s-0042-102652
HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
Authors: Anna Budina-Kolomets, Marie R. Webster, Julia I-Ju Leu, Matthew Jennis, Clemens Krepler, Anastasia Guerrini, Andrew V. Kossenkov, Wei Xu, Giorgos Karakousis, Lynn Schuchter, Ravi K. Amaravadi, Hong Wu, Xiangfan Yin, Qin Liu, Yiling Lu, Gordon B. Mills, Xiaowei Xu, Donna L. George, Ashani T. Weeraratna, Maureen E. Murphy
Journal: Cancer Research (2016)

The stress-inducible chaperone protein HSP70 (HSPA1) is implicated in melanoma development, and HSP70 inhibitors exert tumor-specific cytotoxic activity in cancer. In this study, we documented that a significant proportion of melanoma tumors express high levels of HSP70, particularly at advanced stages, and that phospho-FAK (PTK2) and BRAF are HSP70 client proteins. Treatment of melanoma cells with HSP70 inhibitors decreased levels of phospho-FAK along with impaired migration, invasion, and metastasis in vitro and in vivo Moreover, the HSP70 inhibitor PET-16 reduced levels of mutant BRAF, synergized with the BRAF inhibitor PLX4032 in vitro, and enhanced the durability of response to BRAF inhibition in vivo Collectively, these findings provide strong support for HSP70 inhibition as a therapeutic strategy in melanoma, especially as an adjuvant approach for overcoming the resistance to BRAF inhibitors frequently observed in melanoma patients. Cancer Res; 76(9); 2720-30. ©2016 AACR.
Moving From Disease-Centered to Patient Goals–Directed Care for Patients With Multiple Chronic Conditions
Authors: Mary E. Tinetti, Aanand D. Naik, John A. Dodson
Journal: JAMA Cardiology (2016)

Decision making in cardiology concentrates on diseasespecific outcomes following practice guidelines for specific conditions.Quality metrics implemented for valuebased purchasing and public reporting also largely focus on individual diseases.Disease-centered approaches are appropriate when individuals have a single predominant disease and everyone with the disease desires the same outcome, such as prolonged survival or stroke prevention. 1 This disease-centered framework is illsuited, however, for persons with multiple chronic conditions, including most older adults with cardiovascular conditions and the majority of adult health care users of all ages. 2 Disease-centered decision making for this population results in treatment burden when patients must adhere to multiple guidelines and harm when guideline recommendations conflict. 3Furthermore, disease-centered recommendations may not address what matters most to these patients who vary in their health priorities. 4o consider an alternative to disease-centered decision making that better aligns care with what matters most to patients and reduces treatment burden, it is helpful to think of health care decisions as value propositions in which value = health outcome / cost.From the population perspective, health care value is defined as survival or disease benefit (output) per dollar spent (input).From patients' perspective, however, the personal health outcomes that they hope to achieve are more appropriate outputs. 4The appropriate inputs may include financial costs, but often more relevant are costs in terms of the time, discomfort, harms, and workload required to achieve their health outcomes. 3When defined as what patients are willing and able to do for their health, these broader costs inform care preferences.An alternative approach to decision making, therefore, is predicated on achieving patients' specific health outcome goals within the context of their acceptable workload.High-value care is defined as achievement of each patient's highest-level health outcome goals given the workload each is willing and able to perform.This is not as daunting a task as it may seem; patients implicitly consider trade-offs between outcome and workload even if it is not explicitly discussed. 3Examples of health outcome goals and patient workload are shown in the Box.This approach represents a shift from diseasecentered to patient goals-directed care.The idea that health care decisions should include patients' health VIEWPOINT
PET Adapted Salvage Therapy for Advanced Hodgkin Lymphomas: Towards the Suppression of Positive Interim PET Unfavorable Prognosis? a Report of the Goelams Multicentric Phase 2 Trial LH2007
Authors: Sylvain Carras, Benjamin Dubois, Delphine Senecal, Philippe Quittet, jean-Philippe Vuillez, Michel peoc'H, jean-Philippe Jais, Thierry Lamy, Lysiane Molina
Journal: Blood (2015)
CBM-03MOLECULAR CHARACTERIZATION OF GLIOMA CIRCULATING TUMOR CELLS (gCTCs) AT SINGLE CELL RESOLUTION
Authors: Mariana Cooke, Deeksha Saxena, Gary Kao, Louise Aguarin, Phillip Cheng, David Steinmetz, Gabriela Fenolallal, Michelle Alonso-Basanta, Donald O'Rourke, Steven Brem, Robert Lustig, Jay Dorsey
Journal: Neuro-Oncology (2015)

Glioblastoma multiforme (GBM), the most aggressive and most common malignant adult brain tumor, accounts for ∼50% of all gliomas and it is classified histologically as grade IV. Growing evidence for intratumor heterogeneity shows that single-site biopsies or selected profiling of a portion of a resected tumor falls short of revealing the complete genomic landscape of the entire tumor. EGFR amplification occurs in ∼50% of primary GBM tumors, and is frequently associated with the expression of a constitutively active, ligand-independent mutant form of the receptor, EGFRvIII. Glioma circulating tumor cells (gCTCs) have recently been identified in the blood of glioma patients by our research group. In this study, we report that gCTCs can be captured, enumerated and genetically characterized for EGFRvIII. To achieve this goal, we have thus far a) detected gCTCs through a Telomerase promoter–based assay, b) isolated individual gCTCs using a vacuum-assisted capillary microdissection approach, c) performed whole transcriptome amplification and d) analyzed the expression of EGFRviii by qPCR under optimized conditions. Furthermore, our group is conducting an IRB-approved pilot study with the purpose of examining the feasibility of this approach (to support initiation of an expanded study). In this study, we seek to characterize the genetic heterogeneity of individual gCTCs from high grade glioma patients. This approach would have major impact as it will clarify the biologically-relevant question of heterogeneity of gCTCs in a given patient with glioma, predict whether a patient would respond or be resistant to a molecularly targeted therapy, unravel the overall mechanistic underpinnings of a given patient's brain tumor, and lastly, track the biological evolution of the tumor over the patient's treatment course and post-treatment period. Our ultimate goal is to streamline predictive testing and effectively utilize a Neurooncology targeted biomarker to benefit patients.
Parochial prosocial religions: Historical and contemporary evidence for a cultural evolutionary process
Authors: Ara Norenzayan, Azim F. Shariff, Will M. Gervais, Aiyana K. Willard, Rita A. McNamara, Edward Slingerland, Joseph Henrich
Journal: Behavioral and Brain Sciences (2016)

Abstract In our response to the 27 commentaries, we refine the theoretical claims, clarify several misconceptions of our framework, and explore substantial disagreements. In doing so, we (1) show that our framework accommodates multiple historical scenarios; (2) debate the historical evidence, particularly about “pre-Axial” religions; (3) offer important details about cultural evolutionary theory; (4) clarify the term prosociality; and (4) discuss proximal mechanisms. We review many interesting extensions, amplifications, and qualifications of our approach made by the commentators.
FRI0509 Chromosome 22Q11.2 Deletion Syndrome (Digeorge Syndrome) and Autoimmunity: A French Retrospective Pediatric Study of 15 Cases
Authors: C. Freychet, M. Debré, B. Bader Meunier, I. Lemelle, A. Pagnier, S. Taque, M. Munzer, E. Jeziorski, Y. Hatchuel, D. Launay, P. Quartier, N. Mahlaoui, J.L. Stephan
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The prevalence of autoimmunity in 22q11.2 deletion syndrome (chr22q11DS) is 8.5%. <h3>Objectives</h3> However, there is a lack of clinical description in the literature. <h3>Methods</h3> From a French retrospective study, we have collected the data of autoimmunity in patients with chr22q11DS. For each patient: initial presentation, treatment, outcome, antibodies and lymphocyte subset analyses have been collected. <h3>Results</h3> Fifteen cases were selected. The age at onset of autoimmunity ranged from 1 to 14 years old (median 4 years), most children had several autoimmune manifestations (median 2). Seven patients had autoimmune cytopenias (7 thrombopenias, 5 anemias, 3 neutropenias) and among them, 2 children also had autoimmune hepatitis. Five juvenile idiopathic arthritis were observed: 3 severe polyarthritis rheumatoid factor negative, 1 spondylarthropathy with uveitis and 1 oligoarthritis. 3 children developed mere joint inflammatory pain associated with good response to NSAIDs. Additionally, one celiac disease was diagnosed associated with B+ polyclonal lymphoproliferative disease. One child had autoimmune thyroiditis. A teenager presented acute focal neurological symptoms with hyperintensities of the brain white matter at MRI and positive anti-nuclear and anti-histones antibodies. A Churg-Strauss syndrome was considered, facing severe asthma, nasal polyps, corticosteroid dependence and fever, but ANCA were negative. All patients received several treatments (median 2) and currently, after a median follow-up of 10 years, 10 patients are in complete remission (5 without any treatment and 5 with immunosuppressants), 3 are in partial remission, 1 pancytopenia and 1 polyarthritis are not controlled. The age at chr22q11DS diagnosis ranged from the neonatal period to 16 years (median 7 years). In 8 cases chr22q11DS was diagnosed after the beginning of autoimmunity with a delay from 1 to 11 years (median 7 years). Lymphocyte subset analyses have shown lymphopenia, with a reduction of naïve T-cell count. <h3>Conclusions</h3> Chr22q11DS, similar to other primary immunodeficiencies, must be considered facing atypical autoimmunity, even though clinical dysmorphic features are mild. The diagnosis is easily confirmed by fluorescence in situ hybridization study. Naïve T-cell lymphopenia may predispose to a high risk of autoimmunity. <h3>Disclosure of Interest</h3> None declared
The impact of doxorubicin dose intensity on survival of patients with Ewing's sarcoma.
Authors: M A Smith
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.5.889 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2016632 The impact of doxorubicin dose intensity on survival of patients with Ewing's sarcoma. M A SmithxM A SmithSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.5.889 First Page PDF © 1991 by American Society of Clinical Oncology