tbuckley/cabot-search huggingface dataset:
Prognostic Importance of Myocardial Ischemia Detected by Ambulatory Monitoring Early after Acute Myocardial Infarction
Authors: John B. Gill, John A. Cairns, Robin S. Roberts, Lorrie Costantini, Brian J. Sealey, Ernest F. Fallen, Charles W. Tomlinson, Michael Gent
Journal: New England Journal of Medicine (1996)

After an acute myocardial infarction, it is important to determine the risk of a subsequent coronary event. We studied the prognostic value of myocardial ischemia detected by ambulatory electrocardiographic (ECG) monitoring in patients who had recently had an acute myocardial infarction.
Idiopathic Segmental Infarction of the Greater Omentum
Authors: Cornelius J. Shea, Frank A. Pomer, John W. Spellman
Journal: New England Journal of Medicine (1956)

PRIMARY or idiopathic segmental infarction of the greater omentum is an unusual condition. A review of the literature reveals only 37 reported cases. It is not to be confused with torsion of the greater omentum, which is a fairly well established clinical entity. It is an interesting surgical condition not only because of its rarity but also because it simulates more common and more important acute surgical abdominal emergencies. There are no distinctive clinical features to help establish the diagnosis, and hence no correct preoperative diagnosis appears to have been made. Acute appendicitis and, in 3 cases, acute cholecystitis have . . .
SC-17 * BMP4-SECRETING hAdMSCs ENGINEERED WITH NANOPARTICLES: A NON-VIRAL MSC-BASED THERAPY FOR GLIOBLASTOMA
Authors: A. Mangraviti, S. Tzeng, M. Seng, S. Abbadi, K. Kozielski, P. Schiapparelli, O. Wijesekera, R. Sarabia-Estrada, H. Brem, B. Tyler, A. Olivi, J. Green, A. Quinones-Hinojosa
Journal: Neuro-Oncology (2014)

Mesenchymal stem cells (MSCs) have attracted significant attention as effective delivery vehicles for targeting brain disorders. We have shown that MSCs derived from human adipose tissue (hAMSCs) and genetically modified with viruses display high anti-glioma tropism and can deliver bone morphogenetic protein 4 (BMP4), a therapeutic agent that reduces the clonogenic ability of glioma stem cells. Virus-safety concerns have led to the development of biodegradable nanoparticles that can transfect human cells. We identify nanoparticles for engineering hAMCSs to secrete BMP4 both in vitro and in vivo to treat brain cancer. hAMSCs were transfected using poly (beta-amino ester-PBAE)-based nanoparticles. Transfection efficacy and toxicity were evaluated to determine the optimal formulation to transfect hAMSCs with a BMP4-expressing plasmid. In vitro functional assays evaluated the effect of the transfection on hAMSC phenotype. In vivo imaging and histological analyses tracked engineered hAMSCs (NP-AMSCs) in the brain after local and systemic administration to rodents with orthotopic human tumors. Optimized nanoparticles transfected hAMSCs with 75 ± 2% efficacy and 71 ± 7% viability which was significantly superior (p < 0.0001) to LipofectamineTM 2000(16 ± 3% transfection, 54 ± 5% viability) the leading commercial product. PCR and Western blot analysis confirmed BMP4 production from NP-hAMSCs (52.5 ng protein/106 NP-hAMSCs). NP-hAMSCs were significantly better in migration and invasion (p = 0.005) than hAMSCs transduced with lentivirus. Flow cytometry showed that NP-hAMSCs retain multipotency. Intranasal, intravenous, and local delivery of luciferase- and GFP-expressing NP-hAMSCs in a rodent model of human glioma showed transgene expression 5 days after injection and NP-hAMSC migration towards the brain and within the tumor. We demonstrate that PBAE-nanoparticle formulations effectively transfect hAMSCs to produce BMP4. NP-AMSCs migrate towards the brain and penetrate the tumor in a model of human glioma after local and systemic administration. NP-engineered BMP4-secreting hAMSCs can be a safe and effective alternative to viral transduction for stem cell-based anti-glioma gene therapies.
Multifocal Parathyroid Carcinoma in Subtotal Thyroidectomy
Authors: JOHN H. GRAY, PANUKORN VASINRAPEE
Journal: Clinical Nuclear Medicine (2000)

The authors report the findings of bilateral concurrent parathyroid carcinoma in a patient with a subtotal left thyroidectomy and previous radiation to the neck. Bilateral concurrent parathyroid carcinoma after radiation therapy has not been reported before now.
THE CROHN'S LIFE IMPACT QUESTIONNAIRE (CLIQ): THE FIRST PATIENT-REPORTED OUTCOME MEASURE (PROM) SPECIFIC TO CROHN'S DISEASE (CD)
Authors: J Wilburn, S P McKenna, J Twiss, K Kemp, S Campbell
Journal: Gut (2013)

<h3>Introduction</h3> To determine the impact of Crohn9s Disease (CD) and its treatment from the patient9s perspective a high quality CD-specific PROM is required. This must have; a meaningful theoretical basis, relevant, well-targeted content derived from CD patients and unidimensional, reliable and valid scales. <h3>Aims/Background</h3> This study describes the development of the CLIQ that is shown to meet these criteria. The CLIQ adopted the needs-based model of Quality of Life (QoL) and the World Health Organisation classification of functioning. <h3>Method</h3> The 3 key development stages were; item generation from qualitative patient interviews, assessment of face and content validity in further patient interviews and item reduction and evaluation in a postal survey. Respondents also completed the Nottingham Health Profile (NHP), Unidimensional Fatigue Impact Scale (UFIS) and a demographic questionnaire. Approximately a third of the sample completed the CLIQ again, two weeks later, to determine test-retest reliability (reproducibility). <h3>Results</h3> Thirty qualitative interviews identified 3,000 statements concerning CD and its treatment. Draft scales were assessed by 15 CD patients who found them easy to complete, comprehensive and relevant. The CLIQ was then administered to 273 patients (34.4% male; aged 16–79 (SD 15.1) years. Rasch analyses identified unidimensional scales of QoL and Activity Limitations. Psychometric analyses showed these scales to be reproducible and to have construct validity. <h3>Conclusion</h3> The CLIQ is the first PROM specific to CD. The scientifically rigorous methodology employed ensures that it patient-based outcome accurately and that it will prove valuable in clinical practice, trials and audit.
EXPERIENCIA EN NUESTRO CENTRO DEL EMPLEO DE LA COLEDOSCOPIA
Authors: MA Tejedor Cerdeña, F Geijo Martínez, A Álvarez Delgado, A Velasco Guardado, MC Piñero Pérez, V Prieto Vicente, A Rodríguez Pérez
Journal: Endoscopy (2010)

Introducción: La coledoscopia es una técnica útil para diagnóstico de patología biliar de origen incierto ya que permite la visión directa de la misma.
A New Era of Hepatitis C Therapy Begins
Authors: Donald M. Jensen
Journal: New England Journal of Medicine (2011)

A new era of therapy for hepatitis C virus (HCV) infection is dawning with the development of two effective HCV protease inhibitors, boceprevir and telaprevir. In this issue of the Journal, the results of two phase 3 trials involving boceprevir, in combination with peginterferon and ribavirin, are presented: the SPRINT-2 (Serine Protease Inhibitor Therapy 2) trial (ClinicalTrials.gov number, NCT00705432), by Poordad and colleagues,1 and HCV RESPOND-2 (Retreatment with HCV Serine Protease Inhibitor Boceprevir and PegIntron/Rebetol 2; NCT00708500), by Bacon and colleagues.2 Both studies focused on patients infected with HCV genotype 1; the SPRINT-2 trial involved those who had not previously . . .
SELECTIVE INHIBITION OF THE CARDIAC LATE SODIUM CURRENT WITH ELECLAZINE PROTECTS AGAINST ISCHEMIA-INDUCED ATRIAL FIBRILLATION AND VULNERABILITY TO VENTRICULAR ARRHYTHMIAS
Authors: Fernanda Justo, Henrique Fuller, Bruce Nearing, Sridharan Rajamani, Luiz Belardinelli, Richard Verrier
Journal: Journal of the American College of Cardiology (2016)
Abstract 4198: Characterization of basal cell carcinoma (BCC) allograft in comparison with spontaneous murine BCCs
Authors: Grace Y. Wang, Po-Lin So, Eileen Libove, Ervin H. Epstein
Journal: Cancer Research (2010)

Abstract Small molecule inhibitors against Hedgehog (HH) activity have become one of the hottest targets in cancer drug development. This is because HH pathway has been found to play a role in possibly as many as 30% of all human malignancies, including basal cell carcinoma (BCC), medulloblastoma, rhabdomyosarcoma, pancreatic, gastrointestinal, ovarian, and prostate cancers, some leukemias, and multiple myeloma. Ptch 1+/− mice develop BCCs after UV or ionizing radiation and provide an excellent model system for investigating the HH regulatory system, studying the effect of HH in cancer biology, and evaluating tumor intervention therapies. However, there are intrinsic limitations to the use of autochthonous mouse tumors to investigate therapeutic interventions, including inter-tumor variability and long tumor latency, necessitating the enrolling of numerous mice to assess the efficacy of any intervention. One approach to circumventing these problems is to use tumor allografts. In the present study we aimed to develop BCC tumor allografts, which have not previously been established successfully, and to compare their histology, growth rate, vasculature, and sensitivity to drug treatment with that of their parental tumors. We injected single cell suspensions derived from primary murine BCCs into multiple NOD/SCID mice and compared allograft histology (H&amp;E) and immunophenotype (Ki67, Gli1 and CD31) with that of the parental tumors. We found that allografts generated from the same spontaneous tumor were relatively similar to one another and reproduced the histology of the parental tumor, exhibiting either an infiltrative subtype or a nested structure resembling infiltrative/trichoepithelioma or nodular human BCC subtypes respectively. Consistent with their faster growth rate, allograft tumors showed greater Ki67 staining than did primary tumors. However, allografts expressed slightly reduced Gli1 levels. Similar vascular distribution was observed in both tumor models. Finally, we tested the tumor allograft sensitivity to HH inhibitor treatments. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4198.
Abstract 2188: A high throughput RNAi screen for regulators of thioredoxin in pancreatic cancer cells identifies components of TGFβ-signaling as inducers of thioredoxin expression
Authors: Geoffrey Grandjean, Geoffrey Bartholomeusz, John Kingston, Garth Powis
Journal: Cancer Research (2010)

Abstract Thioredoxin (Txn), thioredoxin reductase (TxnR) and NADPH comprise a thioredoxin system which exists in nearly all living cells functioning in multi-facetted processes in mammalian cells. These include thiol-dependent thiol-disulfide exchange reactions crucial to control the redox homeostasis, cellular growth, defense against oxidative stress and control of apoptosis. Thioredoxin expression has been observed to be elevated in some types of human cancer and has been shown to confer resistance to chemotherapy or radiation-induced apoptosis. It has also been shown that elevated levels of thioredoxin contribute to the carcinogenic process and invasive phenotype of cancer. Identifying key inducers of thioredoxin expression in cancer cells will permit us to specifically target these components with the goal of improving the clinical outcome of treatment of patients with thioredoxin overexpressing cancers. Here, we describe a functional genomic screen designed to identify inducers of thioredoxin expression in which a library of 7040 small interfering RNAs (targeting human kinome and druggable genes) was screened for their ability to block the expression of endogenous thioredoxin in the pancreatic cancer cell line, MiaPaCa2. The primary screen identified numerous potential inducers of thioredoxin expression and, through the use of extensive validation of all these potential hits, yielded 21 high confidence genes that have not previously been associated with the induction of thioredoxin expression. Six of these target genes were associated with TGFβ signaling and selected for this study. Downregulation of these genes strongly inhibited the expression of endogenous thioredoxin in the MiaPaCa pancreatic cancer and other cancer cell lines. Moreover, treating MiaPaCa2 cells with TGF-β1 induced the expression of thioredoxin. TGF-β1-induced expression of thioredoxin is mediated through SMAD2, SNL2, ITGAV, ITGb3 and SP1 thus showing that our study uncovers new aspects of thioredoxin regulation. Collectively, these observations offer several insights on how thioredoxin mediates tumor growth and demonstrates the utility of large-scale RNAi screens in mammalian cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2188.
RESULTADOS DE LA COLONOSCOPIA EN EL PROGRAMA REGIONAL DE DETECCIÓN PRECOZ DEL CÁNCER COLORRECTAL DE CANTABRIA EN EL H. U. MARQUÉS DE VALDECILLA
Authors: A Terán Lantarón, J De la Peña-García, B Castro Senosiain, P Fernández Gil, S Menéndez Secades, L Martín Ramos, A González de Aledo Linos, J Cabezas-González, A Díaz-Pérez, MA Bautista Henríquez
Journal: Endoscopy (2011)

Introducción: Desde el año 2008 se viene trabajando en Cantabria en la implantación y desarrollo del Programa Regional de Detección Precoz del Cáncer Colorrectal (PRDPCC) para población de riesgo medio, basado en la determinación bienal de sangre oculta en heces (SOH) mediante test inmunoquímico. En la primera mitad de 2011 se ha conseguido universalizar el PRDPCC para toda la población de la Comunidad Autónoma de entre 55 y 69 años.
Abstract 1958: Disregulation of TARBP-2 dependent miRNA maturation : A potential new therapeutic target in Ewing sarcoma..
Authors: Claudio De Vito, Nicolo Riggi, Sandrine Cornaz, Ivan Stamenkovic
Journal: Cancer Research (2013)

Abstract We have recently shown that microRNAs (miRNAs) play essential roles is the generation of the cancer stem cell (CSC) phenotype in Ewing sarcoma familly tumors (ESFT). Here we compared the miRNA expression profile of ESFT CSCs to that of embryonic stem cells and CSCs from different tumor, which seem to be shared by these different cell types. Our data suggests that the mechanisms implicated in the miRNAs CSC signature rely on a reversible TARBP-2 dependent miRNA maturation defect. Restoration of TARBP2 activity either through chemical compounds or systemic delivery of synthetic forms of two of its targets, miRNA-143 or miRNA-145, inhibited ESFT CSC growth in vitro and in vivo. Taken together our observations provide new therapeutic strategies through restoration of normal miRNA expression profile, inhibiting CSC self-renewal and tumor maintenance. Citation Format: Claudio De Vito, Nicolo Riggi, Sandrine Cornaz, Ivan Stamenkovic. Disregulation of TARBP-2 dependent miRNA maturation : A potential new therapeutic target in Ewing sarcoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1958. doi:10.1158/1538-7445.AM2013-1958
Two-Year End-Results in the Total Rehabilitation of Veterans with Spinal-Cord and Cauda-Equina Injuries
Authors: Donald Munro
Journal: New England Journal of Medicine (1950)

IN AN earlier paper the results obtained in paraplegic and paraparetic veterans after one year of definitive therapy under my direction at Cushing Veterans Administration Hospital, Framingham, Massachusetts, were summarized.1 Certain comparisons were made with the results obtained in an even larger series of my patients from the Boston City Hospital, and certain minimal end results were suggested. Another year has now elapsed, and it is advisable to publish the two-year figures. Despite the information available since 1940, and despite the organized public demonstration of the possibilities of rehabilitation in these and other chronic invalids, there is virtually a complete . . .
The Pathogenesis of Arthritis Associated with Viral Hepatitis
Authors: Elliot Alpert, Kurt J. Isselbacher, Peter H. Schur
Journal: New England Journal of Medicine (1971)

Eighteen patients with acute viral hepatitis had initial symptoms of arthralgia, arthritis or urticaria. Total serum hemolytic complement (CH50) and C4 tended to be severely depressed in the nine patients studied in the acute phase of their joint symptoms. The C3 levels were moderately depressed, and the C1q levels were widely variable. C1 inhibitor and C9 serum concentrations were normal. Patients with viral hepatitis in convalescence or remission from arthritis, or without a history of these symptoms, had a normal or elevated serum CH50 and C3 level, a widely variable C1q level and low normal C4 levels. Low serum levels of complement in viral hepatitis were associated with high titers of hepatitis-associated antigen. Five patients with acute nonviral hepatitis had normal or elevated serum complement levels. The correlation of joint and skin symptoms with hepatitis-associated antigen and depressed levels of complement activity in the acute state suggests that this serum-sickness-like syndrome may be caused by circulating immune complexes.
Tc-99m MIBI Localization in Bone Marrow: A Marker of Bone Marrow Malignancy
Authors: SHIGETOSHI WAKASUGI, HIROFUMI TESHIMA, HIROYUKI NAKAMURA, TERUMI HASHIZUME, TETSUO MAEDA, AKIRA HIRAOKA, YOSHIHISA HASEGAWA, TOHRU MASAOKA
Journal: Clinical Nuclear Medicine (1998)

To determine the potential of Tc-99m MIBI for detecting bone marrow malignancy, MIBI imaging of the femur was evaluated. There was no detectable MIBI activity in 125 of 141 (89%) control patients. Clearly demonstrated focal or tubular MIBI activity indicating intramedullary accumulation was demonstrated in 44 of 45 (98%) patients with proven marrow malignancy: 9 patients with multiple myeloma, 10 patients with malignant lymphoma, 11 patients with acute leukemia, 1 patient with chronic leukemia, and 14 patients with skeletal metastases. No abnormal MIBI activity was observed in the femur in 19 of 22 (86%) patients who had no evidence of malignant involvement in the femoral marrow, in 3 patients with solitary plasmacytomas of the spine, sternum or iliac bone, or in 16 patients with malignant lymphoma. In 12 of 24 patients with acute leukemia in complete remission, no abnormal MIBI accumulation was shown in the femur, but in 12 patients, abnormal accumulation indicating residual leukemic activity was demonstrated. MIBI imaging correlated extremely well with MRI studies; 26 of 28 patients with focal or tubular increased MIBI activity in the femur showed decreased signal on T1-weighted images and a high signal on short inversion recovery images, and 11 patients with no abnormal activity showed a high signal on T1 images. MIBI imaging of the femoral bone marrow may be a new modality for detecting marrow malignancy.
Amyloidosis of the Tracheobronchial Tree
Authors: Samuel Kamberg, Bernard S. Loitman, Sumner Holtz
Journal: New England Journal of Medicine (1962)

AMYLOIDOSIS of the respiratory tract is a rare condition. Prowse,1 in reviewing the literature, recorded 16 authenticated cases,2 3 4 5 6 7 8 9 most of which were diagnosed at autopsy, and added 2 cases of his own. Two additional cases are reported below, bringing the total number to 20. In both, the diagnosis was made during life by bronchographic studies and bronchoscopic biopsy.Case ReportsCase 1. A 68-year-old janitor was admitted to the St. Louis Veterans Administration Hospital with the initial complaint of pain in the right shoulder of approximately 9 months' duration. A few weeks previously he had had a mild upper-respiratory-tract infection, . . .
MYOCARDIAL SCAR BURDEN INCREASES WITH AGE AND IS ASSOCIATED WITH DECLINE IN LEFT VENTRICULAR SYSTOLIC FUNCTION IN YOUNG PATIENTS WITH BECKER MUSCULAR DYSTROPHY
Authors: Jacob Mathew, Ryan Moore, David Spar, Chet Villa, Jean Bange, Hemant Sawnani, Michael Taylor, Brenda Wong, John Jefferies
Journal: Journal of the American College of Cardiology (2016)
THE DIAGNOSTIC UTILITY OF RISK FACTORS DEFINED BY THE AHA/ACCF EXPERT CONSENSUS STATEMENT ON THE EVALUATION OF CARDIAC DISEASE IN RENAL TRANSPLANT RECIPIENTS
Authors: Aviral Vij, Ibtihaj Fughhi, Tania Campagnoli, Afiachukwu Onuegbu, Chiedozie Anokwute, Meron Teshome, Michael Kharouta, Edward Rojas, George Khoudary, Mohamad Hatahet, Marwan Wassouf, Andrew Appis, Rami Doukky, John H. Stroger
Journal: Journal of the American College of Cardiology (2016)
Abstract 4348: PDGF-Rα expression and activation of the MAPK pathway in disseminated pilocytic astrocytomas
Authors: Alexander C. Engels, Dorota Denkhaus, Astrid Gnekow, Torsten Pietsch
Journal: Cancer Research (2010)

Abstract Background: Pilocytic astrocytomas (PA) are the most common pediatric tumors of the central nervous system. Approximately 5 % of patients with PA present a tumor dissemination. Although the disseminated growth is associated with severe clinical problems, the genetic alterations associated with this biological behaviour have never been investigated. As the histology of the disseminated PAs does not differ significantly to sporadic PAs, we analyzed the mitogen-activated protein kinase (MAPK) pathway for aberrations because genetic alterations of members of this pathway as BRAF and NF-1 have been found to be involved in the pathogenesis of non-disseminated PAs. Methods: Immunohistochemical analysis of the platelet-derived growth factor receptors alpha (PDGF-Rα) and beta (PDGF-Rβ), the epidermal growth factor receptor (EGF-R), and the downstream activated (phosphorylated) extracellular signal-regulated kinase (p-ERK) was performed in a cohort of 18 patients suffering disseminated PAs. In three patients, material of the primary tumor and of relapses could be studied. The BRAF gene was analyzed for mutations by single strand conformation analysis (SSCP) and for gene copy numbers by semiquantitative PCR with fluorescence labelled primers. Mutational hotspots of the K-RAS, H-RAS and N-RAS genes were also analyzed by SSCP. Results: Immunohistochemical analysis showed an increased PDGF-Rα expression in 71.4% of disseminated Pas, but no significant overexpression of EGF-R or PDGF-Rβ. A constitutive ERK phosphorylation was demonstrated in all disseminated PAs investigated. Molecular genetic analysis revealed V600E BRAF mutations in two tumors and an increased BRAF gene copy level in the majority of cases. No RAS mutations were found. Conclusions: This is the first report of molecular genetic analysis of the MAPK pathway in disseminated pilocytic astrocytomas. It underlines the important role of the upstream PDGF-Rα receptor and subsequent MAPK pathway in these gliomas. Its activation represents a potential target for novel strategies in the therapy of disseminated PAs. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4348.