tbuckley/cabot-search huggingface dataset:
Mechanisms underlying the antireflux action of fundoplication.
Authors: A C Ireland, R H Holloway, J Toouli, J Dent
Journal: Gut (1993)

The effect of fundoplication on patterns of gastro-oesophageal reflux and the underlying motor mechanisms were investigated in 18 patients with symptomatic reflux. Oesophageal motility and pH were recorded concurrently after a standard meal. Studies were performed preoperatively and from 5 to 27 months after surgery. Fundoplication virtually eliminated reflux in all but three patients. Control of reflux was associated with a 50% fall in the number of transient lower oesophageal sphincter relaxations, a fall in the proportion of transient lower oesophageal sphincter relaxations accompanied by reflux from 47% to 17%, and an increase in the mean residual pressure at the gastro-oesophageal junction during swallow induced lower oesophageal sphincter relaxation from 0.7 mm Hg to 6.0 mm Hg. Basal pressure at the gastro-oesophageal junction rose from 10.9 mm Hg to 14.5 mm Hg, however, there was no correlation between postoperative reflux and basal gastro-oesophageal junction pressure. These findings suggest that the anti-reflux effects of fundoplication result from changes in the mechanical behaviour of the gastro-oesophageal junction that result in incomplete abolition of the high pressure zone during lower oesophageal sphincter relaxation, and reduced triggering of transient lower oesophageal sphincter relaxations.
Hypothesis: respiratory sinus arrhythmia is an intrinsic resting function of cardiopulmonary system
Authors: J HAYANO, F YASUMA
Journal: Cardiovascular Research (2003)

A hypothesis is presented that explains the physiological reasons why the magnitude of respiratory sinus arrhythmia (RSA) appears to correlate with cardiac vagal tone. The hypothesis is that RSA is an intrinsic resting function of the cardiopulmonary system. Although RSA is mediated by respiratory modulation of cardiac vagal outflow and its magnitude is used as an index of cardiac vagal activity, RSA itself reflects cardiorespiratory interaction. RSA is universally observed among vertebrates throughout the evolution, suggesting that it may bear an intrinsic physiological role. Recent studies have shown that RSA improves pulmonary gas exchange efficiency by matching alveolar ventilation and capillary perfusion throughout respiration cycle. This suggests that in resting animals and humans, RSA could save cardiac and respiratory energy by suppressing unnecessary heartbeats during expiration and ineffective ventilation during waning phases of perfusion. Furthermore, evidence is accumulating for possible dissociation between the magnitude of RSA and vagal control of heart rate, suggesting separated and independent regulations for respiratory modulation of cardiac vagal outflow from those for cardiac vagal tone. By our hypothesis, the apparent associations between RSA and cardiac vagal tone are explained as indirect consequences; i.e., whenever the cardiac vagal tone changes in response to the resting level of the cardiopulmonary system, RSA appears to change parallel to it. Our hypothesis seems more consistent with both physiological and clinical evidence about RSA than that presuming RSA is an index of cardiac vagal activity.
Association Between Preeclampsia and Congenital Heart Defects
Authors: Nathalie Auger, William D. Fraser, Jessica Healy-Profitós, Laura Arbour
Journal: JAMA (2015)

The risk of congenital heart defects in infants of women who had preeclampsia during pregnancy is poorly understood, despite shared angiogenic pathways in both conditions.To determine the prevalence of congenital heart defects in offspring of women with preeclampsia.Population-level analysis of live births before discharge, 1989-2012, was conducted for the entire province of Quebec, comprising a quarter of Canada's population. All women who delivered an infant with or without heart defects in any Quebec hospital were included (N = 1,942,072 neonates).Preeclampsia or eclampsia with onset before or after 34 weeks of gestation.Presence of any critical or noncritical congenital heart defect detected in infants at birth, comparing prevalence in those exposed and not exposed to preeclampsia.The absolute prevalence of congenital heart defects was higher for infants of women with preeclampsia than those without it. Infants of women with preeclampsia had no increased prevalence of critical heart defects but did have an increased prevalence of noncritical heart defects compared with infants of nonpreeclamptic women. [table: see text]. Among specific defects, prevalence was greatest for septal defects. Compared with infants of women with late-onset preeclampsia, those with early onset (<34 weeks) had greater prevalence of critical heart defects (364.4/100,000 [20/5488]; prevalence ratio, 2.78; 95% CI, 1.71-4.50; prevalence difference, 249.6/100,000; 95%CI, 89.7-409.6) and noncritical heart defects (7306.9/100,000 [401/5488]; prevalence ratio, 5.55; 95%CI, 4.98-6.19; prevalence difference, 6089.2/100,000; 95%CI, 5350.0-6828.3).In this population-based study, preeclampsia was significantly associated with noncritical heart defects in offspring, and preeclampsia before 34 weeks was associated with critical heart defects. However, the absolute risk of congenital heart defects was low.
Idiotype-like determinants on human T lymphocytes alloactivated in mixed lymphocyte culture.
Authors: N Suciu-Foca, C Rohowsky, P Kung, D W King
Journal: The Journal of Experimental Medicine (1982)

T cells alloactivated in 5-d MLC with an HLA-DR-different stimulator acquire the capacity of stimulating the autologous mixed lymphocyte response (AMLR). We have demonstrated that activation of AMLR by allosensitized T cells is determined by the expression of the idiotype receptor for the stimulating HLA-DR alloantigen. This has been shown in experiments in which purified, OKT-3-positive T cell suspensions were first primed for 9 d with AMLR-activated T lymphoblasts, then tested in secondary AMLR with autologous lymphoblasts sensitized to various HLA-DR alloantigens. Accelerated memory responses were induced only by autologous lymphoblasts that had been sensitized against the same HLA-DR specificity as the primary AMLR stimulators. This response was not inhibited by a mouse monoclonal antibody recognizing Ia-like determinants, and was not triggered by human allogeneic resting peripheral blood lymphocytes. Thus, recognition of alloactivated T lymphoblasts in secondary AMLR seems to be specific for the idiotype-like determinants expressed by the autologous stimulators.
The role of psoralen photochemotherapy (PUVA) in the treatment of severe atopic eczema in adolescents
Authors: DJ. ATHERTON, F. CARABOTT, M.T. GLOVER, J.L.M. HAWK
Journal: British Journal of Dermatology (1988)

Fifteen adolescent children with severe, persistent atopic eczema were treated with oral psoralen photochemotherapy (PUVA). This resulted in initial clearance of eczema in 14 of the 15 children, nine of whom achieved a remission. Apart from its effectiveness, a major benefit of this therapeutic approach was that it was associated with resumption of normal growth in children who were previously growing poorly, either as a direct result of severe eczema or its treatment. Nevertheless, against the considerable advantages of PUVA for this group of patients have to be balanced the possible hazards, because relatively high exposures are required in some individuals, both initially to induce clearance and subsequently to maintain it.
Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study
Authors: Brian D. Kent, John F. Garvey, Silke Ryan, Geraldine Nolan, Jonathan D. Dodd, Walter T. McNicholas
Journal: European Respiratory Journal (2013)

Obstructive sleep apnoea (OSA) is associated with significantly increased risk of cardiovascular disease. Carotid ultrasonography and retrospective, uncontrolled, coronary imaging studies have suggested an association of OSA with subclinical atherosclerosis, but there is a lack of prospective, controlled studies directly evaluating the relationship of OSA with occult coronary artery disease. We performed coronary computed tomographic angiography and inpatient-attended sleep studies on a cohort of otherwise healthy males attending our sleep laboratory, and compared coronary artery plaque volume between subjects with low and high apnoea/hypopnoea index (AHI) scores. 29 subjects participated. The median AHI was 15.5 events·h −1 , with subjects who scored above this classified as high AHI. No significant differences were observed in demographic, anthropometric and clinical variables between the high- and low-AHI groups. Coronary plaque volume was significantly greater in the high-AHI group (mean plaque volume 2.6±0.7 mm 2 versus 0.8±0.2 mm 2 ; p=0.017) and, furthermore, correlated significantly with AHI (Spearman’s r=0.433; p=0.019). Following adjustment for dyslipidaemia and fasting plasma glucose levels, AHI remained a significant predictor of plaque volume (standardised β=0.424; p=0.027). In this prospective case–control study, we found that severity of OSA may predict occult coronary atherosclerosis in otherwise healthy overweight or obese male subjects.
Review of<i>The Biology of Multiple Sclerosis</i>
Authors: Bardia Nourbakhsh
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Pregnancy Insulin, Glucose, and BMI Contribute to Birth Outcomes in Nondiabetic Mothers
Authors: Ken K. Ong, Barbro Diderholm, Giuseppina Salzano, Dianne Wingate, Ieuan A. Hughes, Jane MacDougall, Carlo L. Acerini, David B. Dunger
Journal: Diabetes Care (2008)

We investigated the effects of normal variations in maternal glycemia on birth size and other birth outcomes.
Meeting American Diabetes Association guidelines in endocrinologist practice.
Authors: C D Miller, L S Phillips, M K Tate, J M Porwoll, S D Rossman, N Cronmiller, S S Gebhart
Journal: Diabetes Care (2000)

OBJECTIVE: To determine whether American Diabetes Association (ADA) guidelines can be met in the context of routine endocrinology practice. RESEARCH DESIGN AND METHODS: Charts were reviewed for a group of patients who were examined in 1998, followed for &amp;gt; or = 1 year, and had two or more visits during that year. Process measures and metabolic outcomes were studied for patients with type 2 diabetes, and glycemic control was assessed for patients with type 1 diabetes. RESULTS: A total of 121 patients with type 2 diabetes had a mean age of 63 years, a mean BMI of 31 kg/m2, and a mean duration of diabetes of 12 years. Many had comorbidities or complications: 80% had hypertension, 64% had hyperlipidemia, 78% had neuropathy, 22% had retinopathy, and 21% had albuminuria. Management of type 2 diabetic patients was complex: 38% used oral hypoglycemic agents alone (54% of these were using two or more agents), 31% used oral hypoglycemic agents and insulin, and 26% used insulin alone; 42% of patients taking insulin therapy injected insulin three or more times per day. Within 12 months, 74% of patients had dilated eye examinations, 70% had lipid profiles, and 55% had urine albumin screening. Of the patients, 87% had a foot examination at their last visit. Blood pressure levels averaged 133/72 mmHg, cholesterol levels averaged 4.63 mmol/l, triglyceride levels averaged 1.99 mmol/l, HDL cholesterol levels averaged 1.24 mmol/l, and LDL cholesterol levels averaged 2.61 mmol/l. Random blood glucose levels averaged 8.0 mmol/l, and HbAlc levels averaged 6.9 +/- 0.1%. A total of 87% of patients had HbAlc levels &amp;lt; or = 8.0%. A total of 30 patients with type 1 diabetes had mean age of 44 years, a mean BMI of 26 kg/m2, and a mean duration of diabetes of 20 years. All type 1 diabetic patients used insulin and averaged 3.4 injections a day; their average HbAlc level was 7.1 +/- 0.2%, and 80% had HbAlc levels &amp;lt; or = 8.0%. CONCLUSIONS: Although endocrinologists must manage patients with multifaceted problems, complex treatment regimens yield glycemic control levels comparable with the Diabetes Control and Complications Trial and allow ADA guidelines to be met in a routine practice setting.
Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation
Authors: Matthew R. Hayes, Karolina P. Skibicka, Theresa M. Leichner, Douglas J. Guarnieri, Ralph J. DiLeone, Kendra K. Bence, Harvey J. Grill
Journal: Cell Metabolism (2010)
Role of Primary and Secondary Capture for Leukocyte Accumulation In Vivo
Authors: Eric J. Kunkel, James E. Chomas, Klaus Ley
Journal: Circulation Research (1998)

Abstract —Leukocyte accumulation during inflammation depends on the concerted action of selectin and integrin adhesion molecules, which promote capture, rolling, and arrest of these cells on activated endothelium. In addition to interacting with endothelial cells, leukocytes can also adhere to already adherent leukocytes through an L-selectin–dependent mechanism. Initiation of adhesion through this mechanism has been called nucleation and leads to characteristic geometric patterns (ie, clusters and strings) of adherent leukocytes in flow chambers. We have used intravital microscopy of tumor necrosis factor-α (TNF-α)–treated mouse cremaster muscles to quantitatively investigate the potential role of leukocyte-leukocyte adhesion in initiating and maintaining the leukocyte clusters that are commonly observed in inflamed venules. Our data show that in TNF-α–treated venules with diameters between 23 and 108 μm, leukocyte adhesion occurs in clusters that are 19 to 50 μm long and 8 to 44 μm wide. They are almost entirely made up of slow-rolling leukocytes. Of all leukocytes recruited into a cluster (100%), the majority enter the cluster rolling along the endothelium and sharply reduce their velocity in the absence (59%) or presence (15%) of other leukocytes in proximity (one cell diameter). Some of the rolling leukocytes (17%) pass through the cluster without reducing their velocity. Recruitment of leukocytes from the free flow regime into a cluster is a rare event and accounts for only 7 (1.2%) of 476 leukocytes arriving in the cluster. However, of the leukocytes captured from the free flow, 6 initiated contact with a slow-rolling leukocyte rather than making direct contact with the endothelium. Our data show that leukocyte-leukocyte interactions can occur in vivo but are not important for cluster formation. This is confirmed by the observation of normal cluster formation in L-selectin–deficient mice, in which leukocyte-leukocyte interactions under flow are abolished. We conclude that leukocyte-mediated nucleation contributes little to leukocyte recruitment during inflammation in vivo. Cluster formation appears to be dominated by areas of endothelium with a higher expression of E-selectin, because cluster formation is greatly reduced in E-selectin–deficient mice.
SAFETY AND EFFICACY OF HIGH-DOSE SODIUM STIBOGLUCONATE THERAPY OF AMERICAN CUTANEOUS LEISHMANIASIS
Authors: W.Ripley Ballou, DanielM. Gordon, Jose Andujar, J.Bruce Mcclain, G.Dennis Shanks, JonathanD. Berman, JeffreyD. Chulay
Journal: The Lancet (1987)
Treating Drug Abuse and Addiction in the Criminal Justice System
Authors: Redonna K. Chandler, Bennett W. Fletcher, Nora D. Volkow
Journal: JAMA (2009)

Despite increasing evidence that addiction is a treatable disease of the brain, most individuals do not receive treatment. Involvement in the criminal justice system often results from illegal drug-seeking behavior and participation in illegal activities that reflect, in part, disrupted behavior ensuing from brain changes triggered by repeated drug use. Treating drug-involved offenders provides a unique opportunity to decrease substance abuse and reduce associated criminal behavior. Emerging neuroscience has the potential to transform traditional sanction-oriented public safety approaches by providing new therapeutic strategies against addiction that could be used in the criminal justice system. We summarize relevant neuroscientific findings and evidence-based principles of addiction treatment that, if implemented in the criminal justice system, could help improve public heath and reduce criminal behavior.
CQC bosses admit regulator got it wrong over report
Authors: A. O'Dowd
Journal: BMJ (2013)

The Care Quality Commission has been incompetent, complacent, and dysfunctional alongside strong evidence of a cover up, its current leaders have admitted to MPs.

The CQC’s chairman, David Prior, and its chief executive, David Behan, appeared before the parliamentary health select committee on 3 July as part of its inquiry into the organisation and made frank admissions of past mistakes.

The inquiry was sparked after recent revelations that two of the commission’s former senior executives had been present at a meeting where a decision was allegedly taken to cover up a review that exposed its failings in regulating University Hospitals of Morecambe Bay NHS Foundation Trust in Cumbria, where …
A20 Ubiquitin Ligase–Mediated Polyubiquitination of RIP1 Inhibits Caspase-8 Cleavage and TRAIL-Induced Apoptosis in Glioblastoma
Authors: Anita C. Bellail, Jeffrey J. Olson, Xiaolu Yang, Zhijian J. Chen, Chunhai Hao
Journal: Cancer Discovery (2012)

The TNF-related apoptosis-inducing ligand (TRAIL) apoptotic pathway has emerged as a therapeutic target for the treatment of cancer. However, clinical trials have proven that the vast majority of human cancers are resistant to TRAIL apoptotic pathway-targeted therapies. We show that A20-mediated ubiquitination inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma through 2 signaling complexes. A20 is highly expressed in glioblastomas and, together with the death receptor 5 and receptor-interacting protein 1, forms a plasma membrane-bound preligand assembly complex under physiologic conditions. Treatment with TRAIL leads to the recruitment of caspase-8 to the plasma membrane-bound preligand assembly complex for the assembly of a death-inducing signaling complex. In the death-inducing signaling complex, the C-terminal zinc finger (Znf) domain of the A20 ubiquitin ligase mediates receptor-interacting protein 1 polyubiquitination through lysine-63-linked polyubiquitin chains, which bind to the caspase-8 protease domain and inhibit caspase-8 dimerization, cleavage, and the initiation of TRAIL-induced apoptosis in glioblastoma-derived cell lines and tumor-initiating cells.These results identify A20 E3 ligase as a therapeutic target whose inhibition can overcome TNF-related apoptosis-inducing ligand resistance in glioblastoma and thus have an impact on ongoing clinical trials of TNF-related apoptosis-inducing ligand-targeted combination cancer therapies.
A cognitive-behavioural symptom management programme as an adjunct in psoriasis therapy
Authors: D.G. Fortune, H.L. Richards, B. Kirby, S. Bowcock, C.J. Main, C.E.M. Griffiths
Journal: British Journal of Dermatology (2002)

Patients with psoriasis may experience significant psychological and social disabilities. Stress or distress are proposed aggravators of the disease process in psoriasis. Preliminary studies to date have suggested that adjunctive psychological therapies may be effective in the clinical management of psoriasis.To examine whether a 6-week multidisciplinary management approach, the Psoriasis Symptom Management Programme (PSMP) for patients with psoriasis improves clinical severity of psoriasis and its associated psychological distress and disability.In a case-control study, patients with psoriasis attending an out-patient psoriasis specialty clinic chose to receive standard psoriasis treatment alone (n = 53) or to enter the PSMP as an adjunct to standard therapy (n = 40). They were assessed at baseline, at the end of the 6-week PSMP and after 6 months follow-up.As compared with standard treatment alone, analysis of covariance indicated that participation in the PSMP resulted in a greater reduction in clinical severity of psoriasis (P = 0.001), anxiety (P = 0.001), depression (P = 0.001), psoriasis-related stress (P = 0.001) and disability (P = 0.04) at 6 weeks and 6 months follow-up.The management of the physical aspects of psoriasis and its psychological effects are significantly improved for patients who opt for a 6-week integrated multidisciplinary approach. Furthermore, the techniques learnt by participation in the PSMP facilitate continued control of psoriasis for at least 6 months.
ALTERATIONS IN THE OXIDATIVE METABOLISM OF RATS WITH INDUCED TOLERANCE: IN VITRO STUDY OF DIAPHRAGM
Authors: Arnold D. Rubin, Joseph Cascarano, Benjamin W. Zweifach
Journal: The Journal of Experimental Medicine (1961)

Oxidative metabolism of diaphragms from endotoxin- and trauma-tolerant rats was investigated, utilizing the reduction of tetrazolium salt. It was found that diaphragms from normal and stress-tolerant animals did not differ in "oxidative performance" (activity in the absence of the redox dye phenazine methosulfate). However, diaphragms from tolerant animals exhibited a highly significant enhancement in "oxidative potential" (activity in the presence of phenazine methosulfate). This change was apparently not precipitated by adjustments in circulatory dynamics, nor was it related to reticuloendothelial stimulation. The suggestion is made that the effects observed may develop through the secondary release of endogenous epinephrine. Evidence is presented suggesting that the enhancement of "oxidative potential" exhibited by the parenchymal tissues of tolerant animals represents an adaptation in metabolism whereby pools of potentially oxidizable foodstuffs are stockpiled.