tbuckley/cabot-search huggingface dataset:
Abstract 1669: Expression of a novel zinc-finger transcription factor ZKSCAN3 in human tumors and its potential as a therapeutic target
Authors: Lin Yang, Robert Z. Orlowski
Journal: Cancer Research (2011)

Abstract Previous studies from our group demonstrated that zinc finger with KRAB and SCAN domains 3 (ZKSCAN3), a novel zinc-finger transcription factor, coordinated a gene expression program targeting Cyclin D1, Cyclin D2, NF- κB, Integrin β4, as well as VEGF and IGF-2, among others, in which these genes have been suggested to play critical roles in tumor progression. To examine if ZKSCAN3 represents a potential cancer therapeutic target, expression of ZKSCAN3 was investigated in multiple tumor types. By immunohistochemistry (IHC), we observed that ZKSCAN3 protein greatly expressed in majority tumor tissues and cells, including solid tumors (colorectal carcinoma, prostate cancer, bladder cancer, and breast cancer) and liquid malignancies (multiple myeloma, non-Hodgkin B cell lymphoma, mantle cell lymphoma, MALT, diffuse large B cell lymphoma), but not non-malignant adjacent tissues. ZKSCAN3 expression was also associated with tumor progression, evidenced by IHC staining in different stages of colorectal carcinoma and prostate cancer samples. Very interestingly, lack of ZKSCAN3 expression was observed in Hodgkin lymphoma and angioimmunoblastic T cell lymphoma, suggesting that ZKSCAN3 selectively expressed in certain tumor types. Moreover, quantitative real-time polymerase chain reaction (qPCR) was performed to verify ZKSCAN3 mRNA expression in multiple myeloma. Consistent with the IHC data, CD19+ normal B cells and CD138+ plasma cells have little expression of ZKSCAN3, meanwhile malignant plasma cells greatly expressed ZKSCAN3 gene. The differential expression pattern of ZKSCAN3 between tumor cells and non-malignant cells strongly suggests that ZKSCAN3 may play an important role in tumor pathogenesis. Indeed, in addition to the identified gene expression program that was regulated by ZKSCAN3, targeting ZKSCAN3 by its small interfering (si) RNA led to slowed tumor growth and decreased chemosensitivity, and overexpression of ZKSCAN3 greatly promoted tumor growth and enhanced chemosensitivity in the models of multiple myeloma and colon cancer, indicating that ZKSCAN3 may represent a promising cancer therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1669. doi:10.1158/1538-7445.AM2011-1669
Colorectal Cancer Awareness Issue
Authors: Peter Siersema
Journal: Endoscopy (2015)

Beginning as a national initiative launched by US President Clinton in 2000, recognition of March as the “Colorectal Cancer Awareness Month” is now a global event. Accordingly we are dedicating the March issue of Endoscopy to endoscopic research into colonoscopy methods, optical diagnosis of polyps, and adenoma detection rate.
ET-61 * NOVEL LIPID NANOPARTICLES FOR THE DELIVERY OF NUCLEIC ACIDS TO GLIOBLASTOMA
Authors: A. T. Ashizawa, D. Steindler
Journal: Neuro-Oncology (2014)

Glioblastoma (GBM) remains one of the most lethal types of cancer. Novel therapies are urgently needed for patients with GBM. Recently we demonstrated high expression of ZEB-1 but low expression of microRNA-200 (miR-200) in GBM samples, and that suppressing ZEB-1 expression or re-expressing miR-200 in GBM cells decreased GBM invasion, increased sensitivity to the chemotherapy temozolomide, and prolonged survival in mouse xenotransplantation studies. Therefore, using nucleic acids to modify ZEB-1 or miR-200 expression is a potential novel GBM therapeutic strategy. However, the transport technology that enables nucleic acids to cross the blood brain barrier (BBB) and enter GBM is not available. Brain microvascular endothelial cells (BMEC) found in the BBB are lined with caveolin, scavenger receptors class B type I (SR-B1), and low-density lipoprotein receptors (LDLr), which are essential to the endocytosis/ transcytosis processes of BMEC. We engineered a novel lipid nanoparticle (LNP) that targets caveolin, SR-BI, and LDLr on BMEC. The LNP is composed of phosphatidylcholine (PC), cholesterol (Chol) and poloxamer (PXR). Flow cytometric analysis indicates that LNP composed of PC/Chol/PXR are avidly taken up by BMEC, approximately 23-fold higher than LNP composed of PC only. Intravenous injection of PC/Chol/PXR, but not PC, LNP in mice leads to their accumulation in the central nervous system including the hippocampus and the cerebellum. Fluorescent microscopy reveals that PC/Chol/PXR LNP efficiently delivers fluorescent nucleic acids to human GBM cells, which express 2- to 5-fold higher levels of caveolin than normal brain cells. Our data indicate that the innovative PC/Chol/PXR LNP has high potential to deliver nucleic acids to GBM in vivo, and enable the utility of nucleic acids as a therapeutic modality against GBM. (Supported by UF Research Opportunity Seed Fund, McKnight Brain Institute Therapeutic Discovery and Translational Research Award, NIH/NINDS NS055165 and the McKinney, Maren, and Thompson Regenerative Medicine Funds).
War and development
Authors: T. Dalrymple
Journal: BMJ (2012)

How many lives have been saved, and how many quality adjusted life years obtained, from the medical advances occasioned by war? It would be obscene, even for a health economist, to work it out, yet there is little doubt that war has occasioned such advances, especially in traumatology. Plastic surgery in particular, advanced by the work of Sir Archibald McIndoe (1900-60) during the second world war. One of his patients was Richard Hillary (1919-43), whose memoir, The Last Enemy , was published in 1942 and was instantly recognised as a minor classic.

Hillary was a student at Oxford when the war broke out and he joined the air force. He was a fighter pilot with five enemy planes to his credit …
Abstract C56: Characterization of PinX1 as a coregulator of steroid hormone receptors
Authors: Yamilet Noriega, Miguel Rivas, Elizabeth Langley
Journal: Cancer Research (2011)

Abstract Introduction: Deregulated expression of transcriptional coactivators and corepressors has been implicated in tamoxifen (TAM) resistance, especially in ER+ breast cancer patients. The AF-1 transcriptional activation domain in the N-terminus of ER has been implicated in the tissue specific agonistic effects of TAM. Thus, using the yeast two-hybrid system with the N-terminal region of ERα, we located the PINX1 gene which encodes for a telomerase inhibitor. Objective: In this work, we characterized PinX1 as a coregulator of ERα. Methods and Results: Using GST pull-down assays, we confirmed the direct interaction between PinX1 and the N-terminus of ERα, showing no interaction with the C-terminus either in the presence or absence of estradiol (E2). Transcriptional activation assays using luciferase reporter genes show that PinX1 is capable of increasing ERα transcriptional activity in breast cancer cell lines, at low concentrations, but increasing PinX1 exhibits a negative effect on the transcriptional activity of ERα in these cell lines. However, Pinx1 repressed AF-1 transcriptional activity, as well as AF-2 activity in the presence of E2. ChIP assays verified that the interaction between ERα and Pinx1 occurs on E2 regulated promoters after 2h of incubation with E2. Furthermore, PinX1 inhibits E2 induced proliferation of MCF7 cells, while inhibition of PinX1 by siRNA increases E2 induced proliferation. These results suggest a role for PinX1 as a correpresor of ERα. PinX1 also interacts with the androgen and progesterone receptors. However, we demonstrate that PinX1 is a coactivator of these receptors by luciferase assays, as well as increasing DHT induced proliferation of prostate cancer cell lines. Enhanced expression of PinX1 also deregulates the expression of a number of genes that have a role in cell growth and proliferation in breast cancer cell lines. Conclusions: Our data support a dual role for PinX1 as a correpresor of ERα and a coactivator of AR and PR. Additionally, it may be involved in functions regulating cell growth and proliferation in both breast and prostate cancer cell lines. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr C56.
EUS-guided choledochoduodenostomy for palliative biliary drainage: report of 5 cases
Authors: H Inoue, H Ishikawa, N Mizuno, K Takahashi, A Sawaki, V Bahatia, AAS Salem, ZEA Sayed, K Yamao
Journal: Endoscopy (2006)

Objective: Endoscopic biliary drainage may be unsuccessful in some patients because of failed biliary cannulation, or tumor infiltration limiting papillary access. The alternative method of percutaneous transhepatic biliary drainage (PTBD) has a risk of complications such as bleeding and intra- or extra abdominal bile leakage. Recently, endoscopic ultrasound (EUS) guided biliary stent placement has been described in patients with malignant biliary obstruction. We describe our 5 cases-experience of EUS guided biliary drainage from first portion of the duodenum. Methods: Five cases of choledochoduodenostomy via first portion of the duodenum using convex echoendoscope (GF-UCT240, Olympus, Tokyo, Japan) and needle knife (Zimmon papillotomy knife, Willson-Cook, NC, USA) were performed. We successfuly exchanged the accessories, such as needles, guide wires (Jag wire 0.035inch, 450cm, Boston Scientific, Boston, USA), biliary dilators (Soehendra biliary dilator catheters, SBDC-7 and SBDC-9, Willson-Cook, NC, USA), and stents, several times through the convex echoendoscope. Results: Stent insertion was technically successful in all 5 patients. The procedure was also clinically effective in relieveing jaundice in all cases. One patient developed pnuemoperitoneum one day after procedure, which resolved conservatively with fasting and antibiotics in few days. Early stent occlusion occurred in one patient after 5 weeks, which made a repeat procedure with exchange stent easily. Average patency of stents reaches more than 170 days (31–274 days). Conclusion: EUS-guided choledochoduodenostomy from first portion of the duodenum is a feasible and safe, and become alternative to PTBD for drainage of obstructed biliary system, in the future.
The Surveillance of Communicable Diseases of National Importance
Authors: Alexander D. Langmuir
Journal: New England Journal of Medicine (1963)

IN the introduction to his comprehensive report on the cholera epidemic of 1848–49, William Farr,1 that greatest of statistical epidemiologists, wrote, "If a foreign army had landed on the coast of England, seized all the seaports,. . . ravaged the population through the summer and. . . in the year it held possession of the country slain fifty-three thousand two hundred and ninety-three men, women and children,. . . the task of registering the dead would be inexpressibly painful; and the pain is not greatly diminished by the circumstance that in the calamity to be described the minister of destruction . . .
Breast-Feeding Linked To Decreased Cancer Risk For Mother, Child
Authors: K. L. Smigel
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Breast-Feeding Linked To Decreased Cancer Risk For Mother, Child Get access Kara L. Smigel Kara L. Smigel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 17, 2 November 1988, Pages 1362–1363, https://doi.org/10.1093/jnci/80.17.1362 Published: 02 November 1988
A Moment With the Journal's European Editor, Gordon McVie
Authors: K. Nagy
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article A Moment With the Journal's European Editor, Gordon McVie Get access Kate Nagy Kate Nagy Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 16, 16 August 1995, Pages 1214–1215, https://doi.org/10.1093/jnci/87.16.1214-a Published: 16 August 1995
Heat-Damaged RBC Scan
Authors: Alexander Tamm, Martha Decker, Michael Hoskinson, Jonathan Abele, Vimal Patel
Journal: Clinical Nuclear Medicine (2015)

Intrahepatic splenosis results from autotransplantation of splenic tissue within the liver, usually after splenic trauma or splenectomy. We present a case of a 43-year-old male patient with an incidental liver lesion discovered on abdominal ultrasound. The diagnosis of intrahepatic splenosis was considered after CT and MRI before being definitively made with Tc-labeled heat-damaged RBC scintigraphy. The case report illustrates the imaging characteristics of this rare location of abdominal splenosis.
Genetic Approaches to the Study of Uterine Leiomyomata
Authors: C C Morton
Journal: Environmental Health Perspectives (2000)

The use of a variety of genetic methods to dissect underlying molecular events in tumors continues to be a highly successful approach. Cytogenetic evaluations of uterine leiomyomata have revealed consistent rearrangements that have provided biological landmarks for positional cloning experiments. Genetic linkage analysis makes possible the identification of genes that might predispose women to develop myomas. New gene expression chip methods to study globally the transcripts present in uterine leiomyomata promise insight into molecular pathways in tumor biology.
A4.10 Early bone microarchitecture changes in adjuvant-induced arthritis rats
Authors: Guillaume Courbon, Damien Cleret, Laurence Vico, Hubert Marotte
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background and Objectives</h3> Hallmarks of rheumatoid arthritis (RA) are joint synovitis and subchondral bone erosions, resulting in loss of joint function. However, occurrence and kinetics of periarticular bone loss remain unclear in RA. So, we used the rat adjuvant-induced arthritis (AIA) model to characterise finely bone loss kinetics for 4 different bones from inflamed ankle; then, we investigated early bone microarchitecture changes, at the time of arthritis onset. <h3>Materials and Methods</h3> Seven-weeks-old female Lewis were divided into two groups: AIA and control (CTRL) rats. Arthritis was induced (AIA) or not (CTRL) by injection at the base of the tail of the adjuvant <i>Mycobacterium butyricum </i>defined as day 0. Rats were monitored clinically by arthritic score and ankle perimeter. Erosion occurrence and bone microarchitecture damages were followed longitudinally using micro-Computed Tomography (micro-CT: vivaCT 40, Scanco, Switzerland). All animals were evaluated at microarchitecture level three times: at baseline, at arthritis onset day, and at day 17 after AIA induction. Navicular, astragalus, cuboid, and calcaneus bones were analysed at cortical site, trabecular site, and together. Analysed microarchitecture parameters included bone volume (BV/TV) and surface/volume (BS/BV), trabecular thickness (Tb. Th), cortical porosity (Ct. Porosity), and cortical thickness (Ct. Th). We performed non-parametric statistics. P-values ​​under 0.05 were considered statistically significant. <h3>Results</h3> The clinical signs of arthritis appeared 10 days post-induction in AIA rats. In micro-CT at day 17, we observed that BV/TV, Tb. Th, and Ct. Th parameters were reduced in AIA compared to CTRL rats (p &lt; 0.01). Ct. Porosity, and BS/BV parameters enhanced in AIA rats compared to CTRL rats (p &lt; 0.01). At day 10 (the day of arthritis onset), erosions were observed only in AIA rats, associated with a lower BV/TV in both trabecular and cortical compartments (p&lt;0.01) in AIA compared to CTRL rats. The trabecular bone loss was correlated with a higher BS/BV (p &lt; 0.01) and a lower Tb. Th (p &lt; 0.05) in AIA rats, while the trabecular loss was associated with a higher Ct. Porosity (p &lt; 0.01). Tarsal bones both reacted similarly, but arthritis affected strongly the navicular bone. <h3>Conclusions</h3> A quantified and more accurate profile of bone loss in the AIA model was obtained. The main finding is early bone microarchitecture changes in rat AIA, detectable by micro-CT, inside subchondral bone. These changes occur at the same day of inflammation onset in synovia, and both cortical and trabecular bone losses are present, reinforcing the inside-outside concept.
THE FIRST-EVER PEDIATRIC APPROPRIATE USE CRITERIA IMPLEMENTATION PROJECT: A LARGE MULTICENTER QUALITY INITIATIVE
Authors: Ritu Sachdeva, Wyman Lai, Joseph Allen, Oscar Benavidez, Robert Campbell, Benjamin Eidem, Lara Gold, Michael Kelleman, Leo Lopez, Courtney E. McCracken, Kenan Stern, Rory Weiner, Elizabeth Welch, Pamela Douglas
Journal: Journal of the American College of Cardiology (2015)
Report of the Cancer Therapy Evaluation Program Monitoring Plan for Secondary Acute Myeloid Leukemia Following Treatment With Epipodophyllotoxins
Authors: M. A. Smith, L. Rubinstein, L. Cazenave, R. S. Ungerleider, H. M. Maurer, R. Heyn, F. M. Khan, E. Gehan
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Report of the Cancer Therapy Evaluation Program Monitoring Plan for Secondary Acute Myeloid Leukemia Following Treatment With Epipodophyllotoxins Get access Malcolm A. Smith, Malcolm A. Smith Malcolm A. Smith, M.D., Ph.D., Rm. 741, Executive Plaza North, National Institutes of Health, Bethesda, MD 20892. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lawrence Rubinstein, Lawrence Rubinstein Cancer Therapy Evaluation Program, Division of Cancer Treatment, National Cancer InstituteBethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lorraine Cazenave, Lorraine Cazenave Cancer Therapy Evaluation Program, Division of Cancer Treatment, National Cancer InstituteBethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard S. Ungerleider, Richard S. Ungerleider Cancer Therapy Evaluation Program, Division of Cancer Treatment, National Cancer InstituteBethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold M. Maurer, Harold M. Maurer Medical College of VirginiaRichmond Search for other works by this author on: Oxford Academic PubMed Google Scholar Ruth Heyn, Ruth Heyn Mott Children's Hospital, Ann Arbor, Mich Search for other works by this author on: Oxford Academic PubMed Google Scholar Farced M. Khan, Farced M. Khan Pediatric Intergroup Statistical CenterHouston, Tex Search for other works by this author on: Oxford Academic PubMed Google Scholar Edmund Gehan Edmund Gehan Pediatric Intergroup Statistical CenterHouston, Tex * “Notes” section following “References”. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 7, 7 April 1993, Pages 554–558, https://doi.org/10.1093/jnci/85.7.554 Published: 07 April 1993 Article history Received: 19 July 1992 Revision received: 03 December 1992 Accepted: 23 December 1992 Published: 07 April 1993
AB0822 Non invasive evaluation of pulmonary arterial hypertension in patient with connective tissue disease
Authors: M. Matsushita, M. Ogasawara, K. Kenpe, K. Yamaji, N. Tamura, Y. Takasaki
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Although pulmonary arterial hypertension (PAH) is a relatively rare disease, it occurs relatively frequently as a complication of connective tissue diseases (CTDs), particularly systemic sclerosis (SSc), mixed connective tissue disease (MCTD), and systemic lupus erythematosus (SLE). PAH is defined as a mean pulmonary artery pressure (PAP) over the 25 mmHg at rest. Right heart catheterization (RHC) is strongly required to evaluate the PAP. However, RHC is invasive and it is also difficult to perform frequently, therefore, alternative noninvasive methods would be required. In this study, we investigated non invasive evaluation of PAH in patient with CTDs. <h3>Objectives</h3> To determine the non invasive evaluation of PAH in patient with CTDs. <h3>Methods</h3> The study subjects were selected from authors’ hospital who fulfilled the CTDs criteria (43 with MCTD, 30 with SSc, 24 with SLE), as well as those with a estimated PAP at rest of 40 mmHg or more were chosen from patients who underwent Doppler echocardiography. Diameters of the main pulmonary artery (d-mPA), right pulmonary artery (d-rPA), and ascending aorta (d-aAO) on thoracic computed tomography (CT) were measured. Moreover, serum brain natriuretic peptide (BNP) levels and % vital capacity (%VC), % forced vital capacity (%FVC), and % diffusing capacity for carbon monoxide (%DLCO) with pulmonary function tests were assessed. The relationship between these results and estimated PAP measured by Doppler echocardiography was evaluated. Static analyses were performed to determine differences in descriptive characteristics between groups. <h3>Results</h3> There were significant correlations between d-rPA/d-aAO and estimated PAP measured by Doppler echocardiography. Moreover, combination of d-rPA/d-aAO and serum BNP levels were significantly useful and using multiple linear regression, it may possible for predict the PAP by calculating formula: [Estimated PAP =77-25.2(d-aAO/d-rPA)+0.02BNP]. On the other hand, %VC/%DLCO and %FVC/%DLCO were useful for predict the existence of PAH but no correlations with estimated PAP. <h3>Conclusions</h3> It is suggested that a combination of d-rPA/d-aAO measured by CT and serum BNP levels are more closely related to estimated PAP measured by Doppler echocardiography and useful in the follow up of patients with PAH associated with CTDs. <h3>Disclosure of Interest</h3> None Declared
LONGITUDINAL ASSOCIATION OF SERUM HOMOCYSTEINE LEVELS WITH ALL-CAUSE MORTALITY IN ADULTS WITH HYPERTENSION: IMPACT OF FOLIC-ACID INTERVENTION AND MTHFR C677T GENE POLYMORPHISM
Authors: Benjamin Xu, Xiangyi Kong, Richard Xu, Zhao Min, Chunyan Zhang, Tao Yu, Lishun Liu, Fangfang Fan, Yan Zhang, Xiao Huang, Xiaoshu Cheng, Xianhui Qin, Binyan Wang, Jin Gu, Xiangyi Li, Yundai Chen, Tianlun Yang, Ningling Sun, Lianyou Zhao, Fan Fan Hou, Junbo Ge, Qiang Dong, Yingxian Sun, Yong Huo, Li Jianping
Journal: Journal of the American College of Cardiology (2016)
Diagnosis and Treatment of Gonorrhea in the Female
Authors: James B. Lucas, Eleanor V. Price, J. D. Thayer, Arnold Schroeter
Journal: New England Journal of Medicine (1967)

SEVERAL factors inherent in the natural history of gonorrhea have prevented successful control. The short incubation period, the lack of natural or acquired resistance, decreasing sensitivity to penicillin and changing moral standards are frequently cited as leading reasons why this disease continues to flourish.Another important basic obstacle is the asymptomatic nature of gonorrhea in the female. It is seldom realized that a high percentage of females are completely symptomless and unaware that they are infected. This carrier state provides a reservoir that serves to perpetuate the infection within the population. One of the greatest needs has been for a . . .