tbuckley/cabot-search huggingface dataset:
Esophageal Epithelial Hyperproliferation Following Long-Term Alcohol Consumption in Rats: Effects of Age and Salivary Gland Function
Authors: U. A. Simanowski, P. Suter, F. Stickel, H. Maier, R. Waldherr, D. Smith, R. M. Russell, H. K. Seitz
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Esophageal Epithelial Hyperproliferation Following Long-Term Alcohol Consumption in Rats: Effects of Age and Salivary Gland Function Get access Ulrich A. Simanowski, Ulrich A. Simanowski Department of Medicine, University of HeidelbergFederal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Paolo Suter, Paolo Suter U.S. Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, BostonMass Search for other works by this author on: Oxford Academic PubMed Google Scholar Felix Stickel, Felix Stickel Department of Medicine, University of HeidelbergFederal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Heinz Maier, Heinz Maier Department of Otorhinolaryngology, University of HeidelbergFederal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Rüdiger Waldherr, Rüdiger Waldherr Department of Pathology, University of HeidelbergFederal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Don Smith, Don Smith U.S. Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, BostonMass Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert M. Russell, Robert M. Russell U.S. Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, BostonMass Search for other works by this author on: Oxford Academic PubMed Google Scholar Helmut K. Seitz Helmut K. Seitz Laboratory of Alcohol Research, Liver Disease and Nutrition, Department of Medicine, Salem Medical CenterHeidelberg Helmut K. Seitz, M D., Laboratory of Alcohol Research, Department of Medicine, Salem Medical Center, Zeppelinstr. 11-33, 69121 Heidelberg, FRG. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 24, December 1993, Pages 2030–2033, https://doi.org/10.1093/jnci/85.24.2030 Published: 01 December 1993 Article history Received: 25 May 1993 Revision received: 02 September 1993 Accepted: 09 September 1993 Published: 01 December 1993
Sequential transarterial chemoembolization and percutaneous acetic acid injection therapy versus repeated percutaneous acetic acid injection for unresectable hepatocellular carcinoma: a prospective study
Authors: T.-I. Huo, Y.-H. Huang, J.-C. Wu, J.-H. Chiang, P.-C. Lee, F.-Y. Chang, S.-D. Lee
Journal: Annals of Oncology (2003)
Effects of thiol protease inhibitors on cell cycle and proliferation of vascular smooth muscle cells in culture.
Authors: K L March, R L Wilensky, R W Roeske, D R Hathaway
Journal: Circulation Research (1993)

Smooth muscle proliferation is a prominent feature of the vascular response to mechanical injury. Accordingly, modulation of proliferation has important therapeutic implications for angioplasty restenosis. We have identified a subclass of thiol protease inhibitors (TPIs) that reversibly inhibit bovine aortic smooth muscle cell (BASMC) proliferation in vitro. To define the nature of this inhibition, an evaluation of selected steps in the cell cycle was undertaken. Treatment of BASMCs with benzyloxycarbonyl-Leu-norleucinal (calpeptin) at 100 microM and acetyl-Leu-Leu-norleucinal (TPI-1) at 50 microM was shown to cause a block of platelet-derived growth factor-BB as well as serum-inducible cell cycle progression at a point before the G1-S boundary, reducing the percentage of bromodeoxyuridine-positive cells from 87% to 5% over a 24-hour labeling period. Addition of TPI-1 at various times after serum addition to serum-deprived BASMCs showed 80% of the maximal block of DNA synthesis even when added 6 hours after serum. The cell cycle progression block was gradually lost as the delay from serum to TPI-1 application was increased from 6 to 12 hours. By Northern analysis of mRNA after serum addition, TPI-1 caused a fourfold decrease in the transient elevation of fos and myc proto-oncogene as well as a decrease in the levels of both muscle and nonmuscle actin mRNA induced early after serum addition. Flow cytometric analysis of DNA content and synthesis in BASMCs treated with TPI-1 or calpeptin additionally revealed the presence of a distinct cell cycle block in the G2-M compartment. In the aggregate, these results suggest the existence of more than one molecular site potentially involved in inhibition by TPI of cell cycling in BASMCs.
A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation.
Authors: Helena Carén, Katarina Ejeskär, Susanne Fransson, Luke Hesson, Farida Latif, Rose-Marie Sjöberg, Cecilia Krona, Tommy Martinsson
Journal: Molecular Cancer (2005)

A common feature of neuroblastoma tumours are partial deletions of the short arm of chromosome 1 (1p-deletions). This is indicative of a neuroblastoma tumour suppressor gene being located in the region. Several groups including our have been studying candidate neuroblastoma genes in the region, but no gene/genes have yet been found that fulfil the criteria for being a neuroblastoma tumour suppressor. Since frequent mutations have not been detected, we have now analyzed the expression and promoter CpG island methylation status of the genes UBE4B, KIF1B, PGD, APITD1, DFFA and PEX14 in the 1p36.22 region in order to find an explanation for a possible down-regulation of this region. The current study shows that gene transcripts in high stage neuroblastoma tumours are significantly down-regulated compared to those in low stage tumours in the 1p36.22 region. CpG island methylation does not seem to be the mechanism of down-regulation for most of the genes tested, since no methylation was detected in the fragments analyzed. One exception is the CpG island of APITD1. Methylation of this gene is also seen in blood from control individuals and is therefore not believed to participate in tumour development. The genes UBE4B, KIF1B, PGD, APITD1, DFFA and PEX14 are down-regulated in high stage NB tumours, a feature that can not be explained by CpG island methylation.
THE PRODUCTION OF EXPERIMENTAL NEPHRITIS BY REPEATED PROTEID INTOXICATION
Authors: Warfield T. Longcope
Journal: The Journal of Experimental Medicine (1913)

The repeated injection of small doses of horse serum and egg-white in dogs, cats, rabbits, and guinea pigs that have been sensitized to these proteins, causes injury to the cells of various organs and tissues with resulting inflammatory reactions. The changes are especially marked after intraperitoneal injections in the peritoneum and after intravenous injections in the livers of rabbits and cats, and in the myocardium and kidneys of all groups of animals. In dogs and rabbits, especially, there develops a well marked nephritis characterized by degeneration and necrosis of the epithelium of the loops of Henle, of the collecting tubules, and less frequently of the convoluted tubules. This is accompanied by an extensive small round cell infiltration of the interstitial tissue and later the formation of connective tissue. Together with these changes there are acute and chronic alterations in the glomeruli of all groups of animals. Egg-white in large doses is itself injurious to the kidney of animals, but this slight primary toxicity is probably greatly enhanced through previous sensitization of the animal.
Development of Diabetes in Chinese With the Metabolic Syndrome
Authors: Bernard M.Y. Cheung, Nelson M.S. Wat, Yu Bun Man, Sidney Tam, G. Neil Thomas, Gabriel M. Leung, Chun Ho Cheng, Jean Woo, Edward D. Janus, Chu Pak Lau, Tai Hing Lam, Karen S.L. Lam
Journal: Diabetes Care (2007)

We investigated the association of the metabolic syndrome with new-onset diabetes in the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort.We followed up on 1,679 subjects without diabetes at baseline. Those with a previous diagnosis of diabetes or those who were receiving drug treatment were considered to be diabetic. The remaining subjects underwent a 75-g oral glucose tolerance test (OGTT). Diabetes was defined by plasma glucose > or =7.0 mmol/l with fasting and/or > or =11.1 mmol/l at 2 h.The prevalences of the metabolic syndrome at baseline were 14.5 and 11.4%, respectively, according to U.S. National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) criteria. After a median of 6.4 years, there were 66 and 54 new cases of diabetes in men and women, respectively. The metabolic syndrome at baseline predicted incident diabetes. Hazard ratios (HRs) for the NCEP and IDF definitions of the syndrome were 4.1 [95% CI 2.8-6.0] and 3.5 [2.3-5.2], respectively. HRs for fasting plasma glucose (FPG) > or =6.1 or 5.6 mmol/l were 6.9 [4.1-11.5] and 4.1 [2.8-6.0], respectively. The NCEP and IDF criteria had 41.9 and 31.7% sensitivity and 87.5 and 90.2% specificity, respectively. Their positive predictive values were low, approximately 20%, but their negative predictive values were approximately 95%.The metabolic syndrome, particularly its component, elevated FPG, predicts diabetes in Chinese. An individual without the metabolic syndrome is unlikely to develop diabetes, but one who has it should practice therapeutic lifestyle changes and have periodic FPG measurements to detect new-onset diabetes.
Antibodies to<i>Porphyromonas gingivalis</i>Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology
Authors: Nastya Kharlamova, Xia Jiang, Natalia Sherina, Barbara Potempa, Lena Israelsson, Anne‐Marie Quirke, Kaja Eriksson, Tülay Yucel‐Lindberg, Patrick J. Venables, Jan Potempa, Lars Alfredsson, Karin Lundberg
Journal: Arthritis & Rheumatology (2015)

To investigate the role of the periodontal pathogen Porphyromonas gingivalis in the etiology of rheumatoid arthritis (RA) by analyzing the antibody response to the P gingivalis virulence factor arginine gingipain type B (RgpB) in relation to anti-citrullinated protein antibodies (ACPAs), smoking, and HLA-DRB1 shared epitope (SE) alleles in patients with periodontitis, patients with RA, and controls.
Lenalidomide Restrains Motility and Overangiogenic Potential of Bone Marrow Endothelial Cells in Patients with Active Multiple Myeloma
Authors: Annunziata De Luisi, Arianna Ferrucci, Addolorata M.L. Coluccia, Roberto Ria, Michele Moschetta, Emanuela de Luca, Luisa Pieroni, Michele Maffia, Andrea Urbani, Giulia Di Pietro, Attilio Guarini, Girolamo Ranieri, Paolo Ditonno, Simona Berardi, Antonella Caivano, Antonio Basile, Nicola Cascavilla, Silvana Capalbo, Giovanni Quarta, Franco Dammacco, Domenico Ribatti, Angelo Vacca
Journal: Clinical Cancer Research (2011)

To determine the in vivo and in vitro antiangiogenic power of lenalidomide, a "lead compound" of IMiD immunomodulatory drugs in bone marrow (BM) endothelial cells (EC) of patients with multiple myeloma (MM) in active phase (MMEC).The antiangiogenic effect in vivo was studied using the chorioallantoic membrane (CAM) assay. Functional studies in vitro (angiogenesis, "wound" healing and chemotaxis, cell viability, adhesion, and apoptosis) were conducted in both primary MMECs and ECs of patients with monoclonal gammopathies (MGUS) of undetermined significance (MGEC) or healthy human umbilical vein endothelial cells (HUVEC). Real-time reverse transcriptase PCR, Western blotting, and differential proteomic analysis were used to correlate morphologic and biological EC features with the lenalidomide effects at the gene and protein levels.Lenalidomide exerted a relevant antiangiogenic effect in vivo at 1.75 μmol/L, a dose reached in interstitial fluids of patients treated with 25 mg/d. In vitro, lenalidomide inhibited angiogenesis and migration of MMECs, but not of MGECs or control HUVECs, and had no effect on MMEC viability, apoptosis, or fibronectin- and vitronectin-mediated adhesion. Lenalidomide-treated MMECs showed changes in VEGF/VEGFR2 signaling pathway and several proteins controlling EC motility, cytoskeleton remodeling, and energy metabolism pathways.This study provides information on the molecular mechanisms associated with the antimigratory and antiangiogenic effects of lenalidomide in primary MMECs, thus giving new avenues for effective endothelium-targeted therapies in MM.
Analysis and Reporting of Factorial Trials
Authors: Finlay A. McAlister, Sharon E. Straus, David L. Sackett, Douglas G. Altman
Journal: JAMA (2003)

Although factorial trials have become common, standards for the analysis and reporting of such trials have not been established and, despite concerns about the possibility of unrecognized interactions between therapies in factorial trials, the magnitude of this potential problem is unknown.To examine the rationale, methods, and analysis of randomized factorial trials.We searched MEDLINE, EMBASE, and the Cochrane Controlled Trials Register using the terms factorial, interaction, 2 x 2, 2 by 2, and incremental to identify factorial randomized trials published from January 2000 to July 2002. To identify trials missed by the electronic search, we performed a hand search of English-language trials in a defined topic area (using the term myocardial ischemia [exp]) listed in MEDLINE (1966-2002), EMBASE (1980-2002), and the Cochrane Controlled Trials Register, as well as all trials in any topic area published in December 2000, excluding trials reporting only continuous surrogate end points. The final set of 33 eligible publications described 29 unique trials.Two investigators independently identified factorial trials, generated a list of items affecting validity of results, and abstracted these items from each trial.The sensitivity of electronic searching for identifying factorial trials was 76%. Our 3-pronged search strategy identified 44 factorial trials with clinically important binary outcomes: 36 (82%) were done for reasons of efficiency (testing 2 interventions in the same patient population), and 8 (18%) were done to assess the incremental benefits of combining the 2 treatments. All but 1 of the trials reported treatment effects by comparing all patients who received treatment A (ie, those receiving either A alone or both A and B) vs all those not receiving treatment A (ie, those receiving either B alone or neither A nor B). Twenty-nine of the 44 trials (66%) reported the data from each of the treatment groups separately; 26 trials (59%) reported testing for interactions between the treatments. Only 2 of 31 (6%) comparisons demonstrated a statistically significant interaction between the 2 treatments.Accurate interpretation of factorial trials depends on the transparent reporting of data for each treatment cell. Despite concerns about unrecognized interactions, our findings suggest that investigators are appropriately restricting their use of the factorial design to those situations in which 2 (or more) treatments do not have the potential for substantive interaction.
Bcl‐2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus‐Prone Mice and Dampen Interferon‐α Production
Authors: Yifan Zhan, Emma M. Carrington, Hyun‐Ja Ko, Ingela B. Vikstrom, Shereen Oon, Jian‐Guo Zhang, David Vremec, Jamie L. Brady, Philippe Bouillet, Li Wu, David C. S. Huang, Ian P. Wicks, Eric F. Morand, Andreas Strasser, Andrew M. Lew
Journal: Arthritis & Rheumatology (2014)

Objective Interferon‐α (IFNα)–producing plasmacytoid dendritic cells (PDCs) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). IFNα‐related genes are highlighted among SLE susceptibility alleles and are characteristically expressed in the blood of patients with SLE, while in mouse models of lupus, PDC numbers and IFNα production are increased. This study was undertaken to investigate the effects of inhibitors that selectively target different antiapoptotic molecules on the survival of PDCs. Methods PDC numbers, in vitro survival, and expression of antiapoptotic molecules were evaluated in lupus‐prone (NZB × NZW)F1 (NZB/NZW) mice. The impact of Bcl‐2 antagonists and glucocorticoids on PDCs was evaluated in vitro and in vivo. IFNα production by NZB/NZW mice was evaluated before and after treatment with Bcl‐2 antagonists. Results PDCs, but not lymphoid tissue–resident conventional DCs, largely relied on the antiapoptotic protein Bcl‐2 for survival. The enlarged PDC compartment in NZB/NZW mice was associated with selectively prolonged survival and increased Bcl‐2 transcription. Functionally, this resulted in enhanced production of IFNα. Bcl‐2 inhibitors selectively killed mouse and human PDCs, including PDCs from SLE patients, but not conventional DCs, dampened IFNα production by PDCs, and synergized with glucocorticoids to kill activated PDCs. Conclusion Enhanced PDC survival is a likely contributing factor to enhanced IFNα production by lupus PDCs. Bcl‐2 antagonists potently and selectively kill PDCs and reduce IFNα production. Thus, we believe that they are attractive candidates for treating PDC‐associated diseases.
Bone marrow lesions predict increase in knee cartilage defects and loss of cartilage volume in middle-aged women without knee pain over 2 years
Authors: A E Wluka, F Hanna, M Davies-Tuck, Y Wang, R J Bell, S R Davis, J Adams, F M Cicuttini
Journal: Annals of the Rheumatic Diseases (2008)

Bone marrow lesions (BML) are important in established knee osteoarthritis, predicting pain and progression of disease. Whether BML are also associated with longitudinal changes in knee structure in an asymptomatic population is unknown.148 healthy pain-free women in middle age with no history of knee injury or clinical knee osteoarthritis who had a magnetic resonance imaging (MRI) scan performed on their dominant knee at baseline, had another MRI 2 years later to assess whether having a BML present at baseline affected change in tibiofemoral cartilage defects and tibial cartilage volume.BML were present in 14.9% of women at baseline. The risk of progression of total tibiofemoral cartilage defects was significantly higher when a very large BML was present (odds ratio 5.55, 95% CI 1.04 to 29.6) compared with when no BML was present, after adjusting for potential confounders. In the lateral compartment, the rate of cartilage volume loss was significantly greater when a BML was present after adjusting for confounders (regression coefficient 39.2 mm(3), 95% CI 11.1 to 67.2, p = 0.007).In healthy women without pain at baseline, large BML were associated with both progression of cartilage defects in the whole tibiofemoral joint and more rapid lateral tibial cartilage loss. These data suggest that the relationship between BML and knee cartilage in healthy women is similar to that described in established osteoarthritis. It is possible that BML may predict an increased risk of knee osteoarthritis and facilitate the identification of novel interventions to prevent disease.
Additive benefits of pravastatin and aspirin to decrease risks of cardiovascular disease: Randomized and observational comparisons of secondary prevention trials and their meta-analysis
Authors: Charles H. Hennekens, Frank M. Sacks, Andrew Tonkin, Wouter Jukema, Robert P. Byington, Bertram Pitt, Donald A. Berry, Scott M. Berry, Neville F. Ford, Andrew J. Walker, Kannan Natarajan, Chen Sheng-Lin, Frederick T. Fiedorek, Rene Belder
Journal: Journal of the American College of Cardiology (2003)
Experimental investigations of the entrapment and persistence of organic liquid contaminants in the subsurface environment.
Authors: L M Abriola, S A Bradford
Journal: Environmental Health Perspectives (1998)

Organic liquids are common polluters of the subsurface environment. Once released, these nonaqueous phase liquids (NAPLs) tend to become entrapped within soils and geologic formations where they may serve as long-term contaminant reservoirs. The interphase mass transfer from such entrapped residuals will ultimately control environmental exposure levels as well as the persistence and/or remedial recovery of these contaminants in the subsurface. This paper summarizes National Institute of Environmental Health Sciences-sponsored research designed to investigate and quantify NAPL entrapment and interphase mass transfer in natural porous media. Results of soil column and batch experiments are presented that highlight research findings over the past several years. These experiments explore dissolution and volatilization of hydrocarbons and chlorinated solvents in sandy porous media. Initial concentration levels and long-term recovery rates are shown to depend on fluid flow rate, soil structure, NAPL composition, and soil wetting characteristics. These observations are explained in the context of conceptual models that describe entrapped NAPL morphology and boundary layer transport. The implications of these laboratory findings on the subsurface persistence and recovery of entrapped NAPLs are discussed.
Gender differences: Implications for pain management
Authors: Ursula Wesselmann
Journal: Behavioral and Brain Sciences (1997)

Despite significant advances in pain research and clinical pain management, little effort has been devoted to exploring whether the same pain treatment strategies are effective for male and female patients. Recent studies indicate that sex differences might play a role in the response to noxious events and in the response to analgesic interventions (berkley) . Further insight into these gender differences will lead to improved pain management for women and men.
Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data
Authors: François-Clément Bidard, Dieter J Peeters, Tanja Fehm, Franco Nolé, Rafael Gisbert-Criado, Dimitrios Mavroudis, Salvatore Grisanti, Daniele Generali, Jose A Garcia-Saenz, Justin Stebbing, Carlos Caldas, Paola Gazzaniga, Luis Manso, Rita Zamarchi, Angela Fernandez de Lascoiti, Leticia De Mattos-Arruda, Michail Ignatiadis, Ronald Lebofsky, Steven J van Laere, Franziska Meier-Stiegen, Maria-Teresa Sandri, Jose Vidal-Martinez, Eleni Politaki, Francesca Consoli, Alberto Bottini, Eduardo Diaz-Rubio, Jonathan Krell, Sarah-Jane Dawson, Cristina Raimondi, Annemie Rutten, Wolfgang Janni, Elisabetta Munzone, Vicente Carañana, Sofia Agelaki, Camillo Almici, Luc Dirix, Erich-Franz Solomayer, Laura Zorzino, Helene Johannes, Jorge S Reis-Filho, Klaus Pantel, Jean-Yves Pierga, Stefan Michiels
Journal: The Lancet Oncology (2014)
IMPLANTABLE CARDIAC RHYTHM DEVICES ARE ASSOCIATED WITH AN INCREASED RISK OF STERNAL WOUND INFECTION AFTER CARDIAC SURGERY
Authors: Alireza Nazeri, James M. Wilson, Abdi Rasekh, Mohammad Saeed, Christopher Frank, Vei-Vei Lee, MacArthur Elayda, Ali Massumi, Mehdi Razavi
Journal: Journal of the American College of Cardiology (2010)
Type II Diabetic Subjects Lose Less Weight Than Their Overweight Nondiabetic Spouses
Authors: Rena R Wing, Marsha D Marcus, Leonard H Epstein, Rose Salata
Journal: Diabetes Care (1987)

To determine whether diabetic individuals have more difficulty losing weight than nondiabetic individuals, 12 overweight diabetic subjects (6 men, 6 women) and their overweight nondiabetic spouses were treated together in a behavioral weight-control program. Diabetic and nondiabetic subjects did not differ in age, weight, or percent overweight. Weight losses of nondiabetic spouses were significantly greater than those of diabetic patients (13.4 ± 1.7 vs. 7.5 ± 1.4 kg; P &amp;lt; .01). Differences emerged by wk 5 and became greater over the 20-wk program. Nondiabetic subjects reduced their intake significantly more than diabetics, suggesting that differences in dietary adherence were responsible for the differences in weight loss.