APLASTIC ANEMIA DURING THE TREATMENT OF HYPERTHYROIDISM WITH TAPAZOLE
Authors: B LEVINE, D V ROSENBERG
Journal: Annals of Internal Medicine (1954)

Case Reports1 October 1954APLASTIC ANEMIA DURING THE TREATMENT OF HYPERTHYROIDISM WITH TAPAZOLEBENNETT LEVINE, M.D., DAVID V. ROSENBERG, M.D.BENNETT LEVINE, M.D.Search for more papers by this author, DAVID V. ROSENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-4-844 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of thiouracil for the treatment of hyperthyroidism there has been a constant search for more potent and less toxic antithyroid drugs. None of these drugs, however, is free from a variety of undesirable toxic side effects. At the present time propylthiouracil and Tapazole (1-methyl-2-mercaptoimidazole) are the drugs most frequently employed because of their proved efficacy and the relatively low incidence of toxic side reactions. Toxic reactions of all types with propylthiouracil have occurred in 1.6 to 3.2 per cent of cases.1-4Severe leukopenia and agranulocytosis have occurred in 0.5 to 1.0 per cent of patients,2-9and several...Bibliography1. BellMishtowt GOGI: Use and abuse of thiouracil drugs, Am. J. Med. 10: 68-76, 1951. CrossrefMedlineGoogle Scholar2. Bartels EC: Agranulocytosis during propylthiouracil therapy, Am. J. Med. 5: 48-52, 1948. CrossrefMedlineGoogle Scholar3. McCullaghHibbsSchneider EPRERW: Propylthiouracil in treatment of hyperthyroidism, Am. J. M. Sc. 214: 545-552, 1947. CrossrefMedlineGoogle Scholar4. Bartels EC: Hyperthyroidism—an evaluation of treatment with antithyroid drugs followed by subtotal thyroidectomy, Ann. Int. Med. 37: 1123-1134, 1952. LinkGoogle Scholar5. LivingstonLivingston HJSF: Agranulocytosis and hepatocellular jaundice, toxic reactions following propylthiouracil therapy, J. A. M. A. 135: 422-425, 1947. CrossrefMedlineGoogle Scholar6. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThyroid hormone regulates hematopoiesis via the TR-KLF9 axisAplastic Anemia Associated with Antithyroid DrugsDrug-induced Aplastic Anaemia: Clinical AspectsThe role of eosinophils in granulopoiesis. I. Eosinophilia in neutropenic pateintsDEATH DURING THERAPEUTIC STARVATIONAPLASTIC ANÆMIA AFTER PROPYLTHIOURACILThe Relative Toxicity of Antithyroid DrugsRefractory anemias of pregnancyCortisone and its Analogues in Alimentary DisordersCortisone and its Analogues in HaematologyBONE MARROW DEPRESSION SUCCESSFULLY TREATED WITH HYDROCORTISONE AND CORTICOTROPIN (ACTH)*JOHN F. MURRAY, M.D., S. FRED RABINER, M.D., BERNARD KABAKOW, M.D.Thyreostatika 1 October 1954Volume 41, Issue 4Page: 844-848KeywordsAdverse reactionsAplastic anemiaDrugsHospital medicineHyperthyroidism ePublished: 1 December 2008 Issue Published: 1 October 1954 PDF downloadLoading ...