tbuckley/cabot-search huggingface dataset:
Biodistribution and clearance of 99mTc-labeled Arg-Gly-Asp (RGD) peptide in rats with ischemic acute renal failure.
Authors: E Noiri, M S Goligorsky, G J Wang, J Wang, C J Cabahug, S Sharma, B A Rhodes, P Som
Journal: Journal of the American Society of Nephrology (1996)

Based on the previous demonstration of a renoprotective effect of arginine-glycine-aspartic acid (RGD) peptides in acute renal failure, experiments were designed to test the distribution and renal accumulation of the peptide. To accomplish this goal, in this study, RGD peptide was radiolabeled and its biodistribution and renal accumulation was determined in rats with ischemic acute renal failure (ARF). 99mTc-RGD with or without 111In-DTPA were injected intravenously in control and ARF rats. Various organs were dissected at different times after injection and subjected to gamma-scintillation counting and autoradiography (ARG). Blood clearance of 99mTc-RGD was rapid, with t1/2 < 10 min, and unchanged in ARF compared with control rats. Kidneys retained the largest portion of the injected dose in both control and ARF rats, as detected using scintillation counting and whole-body ARG (10.56 +/- 1.05% and 10.12 +/- 3.16% injected dose/g wet weight, respectively). Renal ARG revealed a significant increase in binding to the cortex in ARF kidneys, compared with that of control kidneys. Given the differences in renal blood flow and GFR in control and postischemic kidneys, the next series of experiments was performed with two radiopharmaceuticals, 99mTc-RGD and 111In-DTPA. The ratio of 99mTc-RGD:111In-DTPA was increased more than three-fold in ARF kidneys compared with control kidneys (2.7 +/- 0.15 versus 0.8 +/- 0.19, respectively). The results indicate that (1) RGD peptide undergoes a rapid clearance predominantly via the renal route; (2) despite a significant reduction in the renal perfusion, 99mTc-RGD peptide accumulates in the postischemic kidney; (3) this is consistent with the hypothesis on the involvement of RGD-recognizing integrins in the development of tubular obstruction in renal ischemia.
Carcinogenicity of Three Dose Levels of 1,4-Bis(4-fluorophenyl)-2-propynyl-&lt;italic&gt;N&lt;/italic&gt;-cyclooctyl Carbamate in Male Sprague-Dawley and F344 Rats&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: E K Weisburger, B M Ulland, R L Schueler, J H Weisburger, P N Harris
Journal: JNCI Journal of the National Cancer Institute (1975)

Feeding 1,4-bis(fluorophenyl)-2-propynyl-N-cyclooctyl carbamate to F344 or Sprague-Dawley male rats at 125-500 ppm in the diet led to many carcinomas of the small intestine and ear duct (Zymbal's gland tumors) in addition to lymphomas and leukemias. A high incidence of mammary adenocarcinomas was found in the Sprague-Dawley rats. Only a few colon or liver tumors were observed in each strain.
Pathology Panel for Lymphoma Clinical Studies: A Comprehensive Analysis of Cases Accumulated Since Its Inception&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: H Kim, R J Zelman, M A Fox, J M Bennett, C W Berard, J J Butler, G E Byrne, R F Dorfman, R J Hartsock, R J Lukes, R B Mann, R S Neiman, J W Rebuck, W W Sheehan, D Variakojis, J F Wilson, H Rappaport
Journal: JNCI Journal of the National Cancer Institute (1982)

Journal Article Pathology Panel for Lymphoma Clinical Studies: A Comprehensive Analysis of Cases Accumulated Since Its Inception Get access Hun Kim, M.D., Hun Kim, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald J. Zelman, M.S., Ronald J. Zelman, M.S. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael A. Fox, Ph.D., Michael A. Fox, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar John M. Bennett, M.D., John M. Bennett, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Costan W. Berard, M.D., Costan W. Berard, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar James J. Butler, M.D., James J. Butler, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerald E. Byrne, Jr., M.D., Gerald E. Byrne, Jr., M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald F. Dorfman, M.D., Ronald F. Dorfman, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J. Hartsock, M.D., Robert J. Hartsock, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J. Lukes, M.D., Robert J. Lukes, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Risa B. Mann, M.D., Risa B. Mann, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard S. Neiman, M.D., Richard S. Neiman, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar John W. Rebuck, M.D., Ph.D., John W. Rebuck, M.D., Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar William W. Sheehan, M.D., William W. Sheehan, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Daina Variakojis, M.D., Daina Variakojis, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar John F. Wilson, M.D., John F. Wilson, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Henry Rappaport, M.D. Henry Rappaport, M.D. 19 19Address reprint requests to Dr. Henry Rappaport, City of Hope National Medical Center, Duarte, Calif. 91010. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 68, Issue 1, January 1982, Pages 43–67, https://doi.org/10.1093/jnci/68.1.43 Published: 01 January 1982 Article history Received: 20 February 1981 Accepted: 07 August 1981 Published: 01 January 1982
Bacteriuria and Oral Contraceptives
Authors: M. Takahashi
Journal: JAMA (1974)

The association of oral contraceptive use and urinary tract infection was studied in 12,076 middle-class women, aged 18 to 54 years, who came for routine health examination. The prevalence of bacteriuria, defined as two consecutive, positive (more than 100,000 colonies per milliliter) urine cultures, was 1.9% in the entire population studied and was 1.6%, 1.8%, and 2.4% in those never using oral contraceptives and past users and current users of oral contraceptives respectively. These differences were entirely accounted for by<i>Escherichia coli</i>infections. Higher prevalence was seen in users of oral contraceptives, respectively. These differences were entirely and pills with higher estrogen doses. There was no consistent pattern of rates by duration of oral contraceptive use nor with progestogen dose.
Abstract 18411: Dietary Intake of n-3 Long-Chain Polyunsaturated Fatty Acids, Diabetes Mellitus and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease
Authors: Ottar Nygård, Elin Strand, Eva R Pedersen, Marta Ebbing, Gard Svingen, Hall Schartum-Hansen, Bodil Bjørndal, Reinhard Seifert, Klaus Mayer, Dennis W Nilsen, Jan E Nordrehaug
Journal: Circulation (2012)

Background: A high intake of n-3 long-chain polyunsaturated fatty acids (LCPUFAs) is usually recommended in secondary prevention of coronary heart disease, particularly in patients with high triglyceride levels. Furthermore, a beneficial effect has been observed in patients with heart failure, who are frequently insulin resistant. Objective: The aim was to study the influence of impaired glucose metabolism and diabetes mellitus on the relation between dietary intake of n-3 LCPUFAs and risk of acute myocardial infarction (AMI) in patients undergoing coronary angiography for suspected coronary artery disease in 2000-2004. Design: This study included 2378 participants of the Western Norway B-Vitamin Intervention Trial (WENBIT). Daily intakes of n-3 LCPUFAs were estimated based on average dietary intakes during the last year as reported in a food-frequency questionnaire at baseline. Hazard ratios (HRs (95% CI)) of AMI (fatal and non-fatal) according to n-3 LCPUFA intake were calculated using Cox-regression adjusted for cardiovascular risk factors by comparing upper vs. lowest tertile and as trend across tertiles. Patients were followed until 31 December 2006. Results: Mean age of the participants was 62 years and 80% were male. Patients were sub-grouped into non-diabetics (HbA1c &lt;5.7%), pre-diabetics (HbA1c ≥5.7%), and diabetics (diagnosed), and were also stratified according to median triglyceride levels. Among patients with diabetes there was a significantly reduced risk of AMI in the upper vs. the lowest tertile of n-3 LCPUFA intake, multivariate HR (95% CIs) 0.34 (0.14, 0.82), P for trend=0.008. In non-diabetic patients with HbA1c &lt;5.7% there was an increased risk of AMI in the upper tertile of n-3 LCPUFA intake, 1.97 (1.05, 3.67), P for trend=0.02. Risk estimates were strengthened in their respective directions in both diabetic and non-diabetic patients with triglyceride levels above median. No risk associations were seen in pre-diabetics. Conclusions: Among patients with established coronary artery disease, a high intake of n-3 LCPUFAs was associated with a reduced risk of AMI in diabetic patients and an increased risk of AMI in non-diabetic patients. The effects were particularly pronounced in those with elevated triglyceride levels.
A Method To Quantify the Potency of Photosensitizers That Modify Cell Membranes&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: John P. Pooler, Dennis P. Valenzeno
Journal: JNCI Journal of the National Cancer Institute (1982)

The numerical assessment of sensitizing potency of different species of photosensitizer molecules has historically been impracticable because of the difficulty of measuring all of the factors that must be taken into account. This paper describes a new method for quantifying relative sensitizer potency that obviates most of the past difficulties. The physical data needed to assess photosensitizing potency are the absorption spectrum of a sample of medium containing sensitizer, the illumination spectrum impinging on the preparation, the duration of illumination, and the amount of light-induced modification. The measurement of these quantities is relatively straightforward, but it is easy to overlook a number of artifacts that can distort the values for potency. Avoiding error requires careful attention to the optical properties of the system, particularly in the light path through the medium containing sensitizer.
Syncope and the Risk of a Subsequent Motor Vehicle Crash
Authors: Donald A. Redelmeier, Sheharyar Raza
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay
Authors: Brandon Chin Sos, Ho-Lim Fung, Derek Rui Gao, Trina Faye Osothprarop, Amirali Kia, Molly Min He, Kun Zhang
Journal: Genome biology (2016)

Chromatin accessibility captures in vivo protein-chromosome binding status, and is considered an informative proxy for protein-DNA interactions. DNase I and Tn5 transposase assays require thousands to millions of fresh cells for comprehensive chromatin mapping. Applying Tn5 tagmentation to hundreds of cells results in sparse chromatin maps. We present a transposome hypersensitive sites sequencing assay for highly sensitive characterization of chromatin accessibility. Linear amplification of accessible DNA ends with in vitro transcription, coupled with an engineered Tn5 super-mutant, demonstrates improved sensitivity on limited input materials, and accessibility of small regions near distal enhancers, compared with ATAC-seq.
Hemolytic transfusion reactions in oncology patients: experience in a large cancer center.
Authors: B Lichtiger, E Perry-Thornton
Journal: Journal of Clinical Oncology (1984)

At The University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, the incidence of hemolytic transfusion reactions over an eight-year period (1974-1981) was analyzed. Only four hemolytic transfusion reactions were reported out of 142,957 transfusions of blood (a frequency of one reaction in 35,739.25 transfusions). This could be due to the following factors: (1) Impairment of immune status related to the malignant process or temporary immunosuppression caused by intensive chemotherapy could enable patients to tolerate incompatible transfusions. (2) The reactions are overlooked or masked by the severity of disease in cancer patients in spite of an elaborate education for nurses, residents/fellows, and staff physicians about the dangers of hemolytic reactions. The figures herein reported are lower than those reported from non-oncology hospital settings.
Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcRγ-chain complex
Authors: Hervé Falet, Kurt L. Barkalow, Vadim I. Pivniouk, Michael J. Barnes, Raif S. Geha, John H. Hartwig
Journal: Blood (2000)
Clinical significance and management of right heart thrombi: more questions than answers
Authors: David Jiménez, Roger D. Yusen
Journal: European Respiratory Journal (2016)

Pulmonary embolism (PE) remains one of the leading causes of cardiovascular morbidity and mortality [1]. Acute PE has a spectrum of clinical syndromes and varying clinical outcomes [2, 3]. Estimation of patient prognosis helps to prioritise appropriate management strategies. Risk stratification of patients with PE may identify patients at high risk of early PE-related death who may benefit from escalated surveillance or therapy [4, 5]. Alternatively, clinicians may consider patients deemed at low risk for early complications ( i.e. all-cause mortality, recurrent venous thromboembolism (VTE), and major bleeding) as candidates for partial or complete outpatient PE treatment [6]. According to the recent European Society of Cardiology (ESC) guidelines [7], risk assessment of patients diagnosed with PE should rely on the sequential application of a validated clinical score ( i.e. pulmonary embolism severity index (PESI) or simplified PESI (sPESI)), imaging testing assessing right ventricle (RV) function ( i.e. echocardiography or computed tomographic pulmonary angiography), and cardiac biomarkers ( i.e. cardiac troponins). Though the guidelines state that patients who have acute PE associated with right heart thrombi (RHT) have a potentially life-threatening condition, the authors did not formally incorporate the presence or absence of RHT into their PE prognostication algorithm. Haemodynamic status has the strongest prognostic implications for short-term mortality in patients with PE <http://ow.ly/VEARC>
Depressive and Anxiety Disorders Showing Robust, but Non-Dynamic, 6-Year Longitudinal Association With Short Leukocyte Telomere Length
Authors: Josine E. Verhoeven, Patricia van Oppen, Dóra Révész, Owen M. Wolkowitz, Brenda W.J.H. Penninx
Journal: American Journal of Psychiatry (2016)

Several cross-sectional studies have related depressive and anxiety disorders to shorter leukocyte telomere length (LTL) as an indicator of cellular aging. However, these studies have left many unresolved questions about underlying causality and ordering of associations. The objective of the present large, longitudinal study was to examine the relationship between depressive and anxiety disorders and LTL over a 6-year time period.Data are from the Netherlands Study of Depression and Anxiety, including 2,292 patients with remitted and current diagnoses of depressive or anxiety disorders and 644 healthy control subjects. LTL was assessed using quantitative PCR and measured at baseline and after 6 years; depressive and anxiety disorder diagnoses and characteristics (course, duration, and severity) were determined at baseline and after 2, 4, and 6 years.Results showed that persons with remitted (B=-52.6) and current (B=-60.8) depressive or anxiety disorder had consistently shorter LTL compared with healthy control subjects across baseline and at the 6-year follow-up, remaining significant when controlling for lifestyle and somatic health variables. Changes in the course of depressive or anxiety disorder characteristics over 6 years, however, were not associated with different LTL attrition rates.This study confirmed robust associations of depressive and anxiety disorders with shorter telomeres, but interestingly, it did not demonstrate that depressive and anxiety disorders and LTL change together over time, suggesting the absence of a direct within-person relationship. Short LTL is suggested to be either a long-term consequence or an underlying vulnerability factor for depressive or anxiety disorders.
Sleep-disordered breathing and daytime postural stability
Authors: Francis Degache, Yannick Goy, Sopharat Vat, José Haba Rubio, Olivier Contal, Raphaël Heinzer
Journal: Thorax (2016)

Postural stability depends on the coordination of the central nervous system with visual sense, proprioceptive and vestibular information. Sleep deprivation has been shown to affect this function. The objective of our study was to assess the effects of sleep-disordered breathing (SDB) on postural stability.158 subjects referred for suspected SDB had an overnight sleep study and were placed on a posturographic platform in late afternoon. This platform allows measuring the centre of pressure (CoP) oscillations and to calculate: total displacement of CoP in X and Y axes, mean speed of CoP displacement and the length as function of surface (LFS) ratio (length of CoP displacement/surface of CoP trajectory).98 men and 60 women were included. Mean age±SD was 45.4±5.5 years old, body mass index (BMI) 27.5±5.6 kg/m(2) and apnoea-hypopnoea index (AHI) 13.6±16.1/h. AHI was <5/h in 64 (41%) subjects, 5-15/h in 43 (27%), 15-30/h in 30 (19%) and >30/h in 21 (13%). In patients with an AHI >5/h versus AHI <5/h, we observed an important increase in LFS (+21%, p<0.001), in XY length (+23%, p<0.001) and in mean speed (+23%, p<0.001). After controlling for age, BMI and sleepiness (Epworth) in multivariate regression models, there was a positive association between all nocturnal breathing parameters (specifically: mean SpO2, AHI, oxygen desaturation index 3% and % time with SpO2 <90%) and the main stability outcomes (all p<0.05).SDB severity, especially the mean nocturnal SpO2 level, is associated with impaired daytime postural stability.
Irinotecan (CPT-11) and 5-fluorouracil (5-FU) concomitantly with preoperative radiotherapy (RT) in patients (pts) with locally advanced resectable rectal cancer. Updated results of a phase II study
Authors: E. Dotor, M. Navarro, M. E. Vega, P. Sánchez-Rovira, A. Cervantes, J. L. García, M. Suárez, E. Aranda, D. Asensio, A. García
Journal: Journal of Clinical Oncology (2004)

4179 Background: This phase II trial was designed to determine the pathological response rate of preoperative chemo-radiotherapy. Secondary objectives were: to evaluate the toxicity profile, to determine the disease-free survival (DFS) and overall survival (OS) and the rate of conservative surgery. Methods: Patients with histologically confirmed locally advanced adenocarcinoma of the rectum, (T3 or T4 resectable tumors +/- regional lymph node metastases), no prior treatment for neoplasia, performance status (PS) 0–1, adequate bone marrow, renal and hepatic function. Treatment: CPT-11 50 mg/m2 as a 30 minutes i.v. infusion on days 1, 8, 15, 22 and 29; 5-FU 225 mg/m2/day as a continuous infusion (c.i.) on days 1–5 weekly during the period of RT. Total RT dose: 45 Gy at 1.8 Gy daily during 5 sessions per week (5 weeks treatment duration). Surgery was performed 6–8 weeks following completion of therapy. Results: To date, 74 pts have been included: 49 male, 25 female; median age 63 years (range 20–74); Median tumor distance from anal verge was 6.0 cm (range 0–15). ECOG 0/1: 42%/54.5%.PS was unavailable in 4% (3 pts). Clinical staging pre-treatment was: 22 stage II (29.7%), 45 stage III (60.8%), 7 unclassifiable (9.5%). A total of 354 infusions of CPT-11 and 359 infusions of 5-FU were administered with a median relative dose intensity of 1.0 and 1.03 respectively. Median RT dose was 45.0 Gy. Toxicity was evaluated in 74 pts. Grade 3+ hematological toxicity per pt was lymphocytopenia 47.2%, Neutropenia 5.4%. Grade 3+ non hematological toxicity consisted of diarrhea 13.5%, asthenia 9.5% and proctitis 8.1%. Only 1 pt complained of infection grade 4+ toxicity. Efficacy: 73 pts have undergone surgery and 60 (81%) are evaluable for pathological response: 10 (16.67%) achieved a CR; 34 (56.67%) PR and 11 (18.33%) SD. Sphincter saving surgery was achieved in 44/73 (54.8%) patients. Conclusions: This update confirm our preliminary data that neoadjuvant chemo-radiotherapy appears to be highly active in non-pretreated locally advanced rectal cancer with a favourable toxicity profile. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aventis; Prasfarma/Almirall
Binding of Chemical Carcinogens to Macromolecules in Cultured Human Colon: Brief Communication2
Authors: Herman Autrup, Curtis C. Harris, Gary D. Stoner, Jesudason Michael L., Benjamin F. Trump
Journal: JNCI Journal of the National Cancer Institute (1977)

Metabolic activation of different chemical classes of carcinogens was studied in cultured human colon epithelia. Human colon epithelia were maintained in explant culture up to 4 days. Binding of benzo[a]pyrene, dimethylnitrosamine, and 1,2-dimethylhydrazlne was found In both cell DNA and protein. 1,2-Dimethylhydrazlne methylated DNA at both N-7 and O-6 positions of guanine.