tbuckley/cabot-search huggingface dataset:
Clones With Different Metastatic Capacity and Variant Selection During Metastasis: A Problematic Relationship&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: P Nanni, C De Giovanni, P L Lollini, G Nicoletti, G Prodi
Journal: JNCI Journal of the National Cancer Institute (1986)

Cells from TS/A, a metastasizing line derived from a spontaneous BALB/c mouse mammary adenocarcinoma, were injected either sc or iv in syngeneic mice, and the resulting lung metastases or lung colonies were briefly cultured in vitro and reinjected in mice by the same route; this procedure was repeated 10 times. All the variants obtained did not show a metastatic capacity higher than the parental cell line. Moreover, they gave a number of metastases significantly lower than that produced by high metastatic clones selected in vitro from TS/A. The number of lung colonies obtained with intravenously selected (COL) variants was significantly higher than that obtained with subcutaneously selected (META) variants, TS/A, or in vitro-selected clones; this was already observable after the first cycle of selection. Both COL and META variants did not show the in vitro growth properties of the in vitro-selected high metastatic clones. In conclusion, both intravenous and subcutaneous selection procedures did not lead to an enrichment in high metastatic populations, even if such populations were present in the parental line and had been cloned in vitro; only the intravenous procedure selected high-colonizing variants.
SYMPOSIUM SPONSORS AND COMMITTEE MEMBERS
Authors: A Scott
Journal: British Journal of Sports Medicine (2013)

ISTS2012 was sponsored by the Department of Physical Therapy, the Canadian Institutes of CIHR (meeting planning and dissemination grant), the Vancouver Coastal Health Research Centre, BJSM, Sonosite, The Orthopaedic Biologic Institute, and ASTYM corporation. Thanks to the scientific committee and organising committee. Scientific committee: Alex Scott, Jill Cook, Patrick Danielson, Malcolm Collins, Craig Purdam, Henning Langberg, Nele Mahieu, Paul Ackermann, Roger Smith, Tomas Fernando Fernandez Jaén. Organising committee: Angela Fearon, Callista Haggis, Jacqueline Alexander, Aishwariya Sharma.
PTH-190 Does the Amount of Sedation have an Impact on the Diagnostic Yield of Double Balloon Enteroscopy ? Experience From a Tertiary Centre
Authors: R Sidhu, S Hardcastle, D S Sanders
Journal: Gut (2013)

<h3>Introduction</h3> Double balloon enteroscopy (DBE) offers the ability for diagnostic and therapeutic intervention in the small bowel. The procedure takes an average of an hour to carry out and can be uncomfortable for the patient. It also has an associated learning curve for the endoscopist. The depth of insertion is a subjective estimation of the total number of passes into the small bowel. The success/diagnostic yield of the procedure relies upon patient tolerability and locating the target lesion or bleeding point. The aim of this study was to assess the technical success rate for routine DBE over time in comparison to sedation dose used. <h3>Methods</h3> A prospective review of the 290 DBE procedures done since the start of the service was conducted. The majority of patients underwent a capsule endoscopy either locally or at our centre prior to DBE which helped to guide the chosen route. Data was collected for sedation/analgesia used, procedure length, number of passes into the small bowel and diagnostic yield between the initial 145 (group 1) and latter 145 procedures (group 2). Similar comparisons were also done between the oral and anal routes of DBE. <h3>Results</h3> The DBE procedures were performed from July 2006 to Nov 2012 by two endoscopists. Whilst the median doses of midazolam used between the two groups were similar (median 5 mg versus 6mg, p = 0.8), a greater amount of fentanyl was used in group 2 (median 50mcg versus 100mcg, p &lt; 0.001). There was no difference in the procedure length or the number of passes recorded by the endoscopists. However there was a significant increase in the diagnostic yield in the latter group (32% versus 58%, p &lt; 0.001). A total of 165 oral DBE procedures were done. Whilst there were no differences in the procedures length or number of passes into the small bowel, a greater amount of fentanyl was used in the latter half of the procedures. The diagnostic yield improved significantly in the latter half of the oral DBE procedures (41% versus 61%, p = 0.01). There were 125 anal DBE procedures. There was no difference in procedure characteristics or diagnostic yield for the anal route over time despite higher doses of fentanyl. <h3>Conclusion</h3> This study demonstrates an improved diagnostic yield for DBE over time particularly with the oral route and with a greater amount of fentanyl used. The absence of improvement in yield for the anal route in this study is consistent with the literature to date. The anal route remains a challenge for endoscopists due to difficulty achieving a stable platform in the terminal ileum to progress. More education on retrograde techniques would help overcome this limitation. <h3>Disclosure of Interest</h3> None Declared.
Asthma and Wheezing in the First Six Years of Life
Authors: Fernando D. Martinez, Anne L. Wright, Lynn M. Taussig, Catharine J. Holberg, Marilyn Halonen, Wayne J. Morgan
Journal: New England Journal of Medicine (1995)

Many young children wheeze during viral respiratory infections, but the pathogenesis of these episodes and their relation to the development of asthma later in life are not well understood.
Abstract 3740: Low carbohydrate diets, DASH-style diet and risk of post-menopausal breast cancer
Authors: Teresa Fung, Frank Hu, Susan Hankinson, Walter Willett, Michelle Holmes
Journal: Cancer Research (2011)

Abstract Background: Low carbohydrate diets and the DASH-style diet have not been evaluated for their association with breast cancer. Methods: We prospectively examined the association between the DASH score, overall, animal, and vegetable low carbohydrate diet scores and risk of postmenopausal breast cancer in 86,621 women in the Nurses’ Health Study. Diet scores were calculated from up to 7 food frequency questionnaires (FFQ) during up to 26 years of follow-up. We also examined the association with major plant food groups. Analysis was separately conducted for estrogen receptor status (ER) positive and negative tumors. Results: We ascertained 5,522 incident cases of breast cancer, including 3,314 ER+ and 826 ER- cancers. After adjusting for potential confounders, the DASH score was associated with a lower risk of ER- cancer (RR comparing extreme quintiles=0.80, 95% CI=0.64-1.01, p trend=0.02). However, this is largely explained by higher fruits and vegetables intake. An inverse association was also observed with the vegetable low carbohydrate score (corresponding RR=0.81, 95% CI=0.65-1.01, p trend=0.03). Total fruits and low protein vegetables were association with a lower risk of ER- cancer (RR comparing extreme quintiles=0.71, 95%CI=0.55-0.90, p trend=0.005). Conclusion: A diet high in fruits and vegetables, such as one represented by the DASH score was associated with a lower risk of ER- breast cancer. In addition, a diet high in plant protein and fat and moderate in carbohydrate content is also associated with a lower risk of ER- cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3740. doi:10.1158/1538-7445.AM2011-3740
MENTAL STRESS-INDUCED PLATELET AGGREGATION PREDICTS ADVERSE CARDIOVASCULAR OUTCOME IN ISCHEMIC HEART DISEASE PATIENTS ON DUAL ANTIPLATELET THERAPY
Authors: Julia Sun, Stephen Boyle, Thomas Ortel, Zainab Samad, Michael Babyak, Jennifer Wilson, Cynthia Kuhn, Redford Williams, Joseph Rogers, Eric Velazquez, Christopher O’Connor, Richard Becker, Wei Jiang
Journal: Journal of the American College of Cardiology (2016)
EARLY IMPROVEMENT IN FLOW (LEFT VENTRICULAR STROKE VOLUME INDEX) AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT IS ASSOCIATED WITH IMPROVED SURVIVAL IN LOW-FLOW AORTIC STENOSIS
Authors: Venkatesh Y. Anjan, Howard Herrmann, Philippe Pibarot, William Stewart, Samir Kapadia, E. Murat Tuzcu, Vasilis Babaliaros, Vinod Thourani, Wilson Szeto, Joseph Bavaria, Susheel Kodali, Rebecca Hahn, Mathew Williams, D. Craig Miller, Pamela Douglas, Martin Leon
Journal: Journal of the American College of Cardiology (2015)
SEGUIMIENTO A LARGO PLAZO DE PACIENTES CON LESIONES VASCULARES GASTROINTESTINALES IDENTIFICADAS MEDIENTE CÁPSULA ENDOSCÓPICA Y/O ENTEROSCOPIA
Authors: R Acosta-Materán, JM González-Santiago, A Mora-Soler, C Revilla-Morato, D Pérez-Corte, AB Prieto-Bermejo, A Sánchez Garrido, C Piñero-Pérez, A Álvarez-Delgado, F Geijo-Martínez, A Rodríguez-Pérez
Journal: Endoscopy (2014)

Introducción: Las lesiones vasculares del tracto gastrointestinal constituyen una causa muy prevalente de hemorragia digestiva de origen oscuro (HDOO). La cápsula endoscópica (CE) y la enteroscopia (E) pueden ser métodos diagnósticos complementarios. Objetivo: Determinar características clínicas y factores de riesgo de los pacientes con angiodisplasias gastrointestinales (AG) tras realización de CE y/o E, así como analizar necesidades terapéuticas y tasa de resangrado en el primer año tras diagnóstico. Material y Método: Estudio observacional en el que se incluyeron durante 24 meses (2011 – 2012) pacientes consecutivos con diagnóstico de AG tras CE y/o E con un periodo de seguimiento de 12 meses. Resultados: Se incluyeron 37 pacientes (edad media 62 años, rango 45 – 73, con predominio de varones (56,7%). Comorbilidades más comunes: Cardiopatía crónica (37%) e insuficiencia renal crónica (32%). Se realizaron 34 estudios con CE y 8 estudios mediante E. Todos los explorados mediante E se realizaron tras CE y en 3 casos se detectaron lesiones no descritas en CE. Indicaciones de CE: HDOO de tipo oculto (64,8%), HDOO de tipo evidente (26,9%) y otras causas (8,2%). Distribución: Yeyuno (29,7%), íleon (10,8%), ciego (10,8%), estómago (8,1%), duodeno (5,4%). 15 pacientes (40,5%) precisaron suplementos de hierro (37,8% v. oral, 2,7% parenteral). En 10 casos (27%) el descenso de hemoglobina motivó transfusiones sanguíneas. El 29,7% de los pacientes precisó terapéutica con coagulación con plasma-argón; 73% accesible por E anterógrada o retrógrada y 27% restante mediante gastroscopia y/o colonoscopia. La tasa de resangrado fue del 27% (10/37), siendo preciso en dos casos nueva E terapéutica. Ningún caso requirió cirugía. No aparecieron complicaciones mayores.
POTENTIAL BENEFIT OF USING PRESSURE WIRE IN HEMODYNAMIC ASSESSMENT OF PARADOXICAL LOW FLOW, LOW GRADIENT SEVERE AORTIC STENOSIS WITH PRESERVED EJECTION FRACTION
Authors: Zaher Fanari, Jhapat Thapa, Kamleish Persad, Sumaya Hammami, Michael Kostal, Joseph West, Erik Marshall, William Weintraub, Andrew Doorey
Journal: Journal of the American College of Cardiology (2016)
Three-Dimensional CT Diagnosis of Maxillofacial Trauma
Authors: P N Manson
Journal: New England Journal of Medicine (1994)

Figure 1. Three-Dimensional CT Diagnosis of Maxillofacial Trauma. Spiral computed tomographic (CT) slices (Panel A and Panel B) from which three-dimensional images were reconstructed (Panels C, D, E, and F) were obtained in a 16-year-old boy with facial fractures sustained in a head-on collision. The boy was not wearing a seat belt, and his car was traveling at 50 mph (80 km per hour). He had a slightly limited upward gaze on the right side, a small subconjunctival hemorrhage, and infraorbital pain. There were no other findings on physical examination. A zygomaticomaxillary complex (“tripod”) fracture is present. The zygomatic arch . . .
Somatostatin Receptor Scintigraphy for Bronchial Carcinoid Follow-Up
Authors: Stefano Fanti, Mohsen Farsad, Giuseppe Battista, Francesco Monetti, Gian Carlo Montini, Arturo Chiti, Giordano Savelli, Francesco Petrella, Alessandro Bini, Cristina Nanni, Annadina Romeo, Roberto Franchi, Emilio Bombardieri, Romeo Canini, Nino Monetti
Journal: Clinical Nuclear Medicine (2003)

Purpose: Somatostatin receptor scintigraphy (SRS) has been used to diagnose bronchial carcinoids (BC) and is a valuable tool for accurate staging of BC. The aim of this study was to evaluate the role of SRS in restaging BC and following patients after treatment. Methods: Thirty-one patients (18 male, 13 female) with confirmed BC who were referred during the last 7 years were included. Patients were examined via chest radiograph (12 studies), chest or abdominal computed tomography (CT; 28 scans), chest magnetic resonance imaging (2 scans), and liver ultrasound (5 scans). Results: Overall, in 22 patients (71%), SRS confirmed the data obtained by other diagnostic procedures (16 negative and 6 positive findings). In 6 patients, SRS showed focal lesions not previously demonstrated. In 2 patients, SRS resolved uncertain findings of CT. In 1 patient, SRS showed fewer lesions compared with CT. In 8 of 31 patients, important diagnostic information obtained by SRS was not revealed by any other imaging procedure. Conclusion: Our results indicate that SRS is a reliable, noninvasive method that could be considered the principal follow-up procedure in patients with BC.
Effect of the Angiotensin-Converting–Enzyme Inhibitor Benazepril on the Progression of Chronic Renal Insufficiency
Authors: Giuseppe Maschio, Daniele Alberti, Gérard Janin, Francesco Locatelli, Johannes F.E. Mann, Mario Motolese, Claudio Ponticelli, Eberhard Ritz, Pietro Zucchelli
Journal: New England Journal of Medicine (1996)

Drugs that inhibit angiotensin-converting enzyme slow the progression of renal insufficiency in patients with diabetic nephropathy. Whether these drugs have a similar action in patients with other renal diseases is not known. We conducted a study to determine the effect of the angiotensin-converting–enzyme inhibitor benazepril on the progression of renal insufficiency in patients with various underlying renal diseases.
FRI0588-HPR Validation of the Italian Neck Bournemouth Questionnaire: Construct Validity, Responsiveness and Interpretability
Authors: T. Geri, A. Signori, M. Testa
Journal: Annals of the Rheumatic Diseases (2014)

Background Neck pain is a musculoskeletal disorder causing high societal and economic costs. The comparison of different treatment strategies across several countries using validated outcome measure is vital in the field of neck pain research. As the Neck Bournemouth Questionnaire (NBQ) holds validated versions with acceptable psychometric properties in several languages, we studied the psychometric properties of the questionnaire in the italian population. Objectives Cross-cultural adaptation and validation of the Italian NBQ (NBQ-I). Methods The forward and back translations of the questionnaire produced the pre-final version, which was adopted as the italian version of the questionnaire (NBQ-I) after preliminary testing on the target population and final approval by an expert committee. The questionnaire was administered in two times, being respectively the beginning and the end of a physiotherapy treatment delivered to the patients with neck pain attending the rehabilitation unit of Santa Corona Hospital (Pietra Ligure, IT). The construct validity and responsiveness were computed by means of hypotheses testing regarding the absolute magnitude of correlations of, respectively, the test scores and change score of the NBQ-I using the Neck Pain and Disability Scale (NPDS), the Numerical Rating Scale for pain intensity (PAIN-NRS), the EuroQoL 5 Dimension Index (EQ5D-IND) and its Numerical Rating Scale for quality of life (EQ5D-NRS) as comparators. The mean change score between the two administrations, the Minimal Clinical Important Difference (MCID) and the floor and ceiling effects were the values used to describe the interpretability. Results The NBQ had acceptable psychometric characteristics ([Table 1][1]). 96 subjects with chronic neck pain completed the questionnaire's administration. The results of the hypotheses testing process revealed a moderate-to-high construct validity and a poor responsiveness of the NBQ-I. The change score had mean 9.4 (SD =13.3) and MCID 5.5 points. Floor and ceiling effects were not observed. ![Figure][2]</img> Conclusions The NBQ-I was successfully validated in a sample of subjects with chronic neck pain. The good construct validity was further supported because the correlations of the test scores with the comparator instruments reflected those observed in different languages. Although the responsiveness was poor, the change score to detect a clinical improvement in the subjects was minimal and resembled those observed in similar populations.1 A limit of this study was the absence of the reliability analysis. References 1. Gay RE, Madson TJ, Cieslak KR. Comparison of the neck disability index and the neck bournemouth questionnaire in a sample of patients with chronic uncomplicated neck pain. J Manipulative Physiol Ther 2007;30:259-262. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.2339 [1]: #F1 [2]: pending:yes
Abstract 1314: Real-time imaging of individual cancer cell nuclear-cytoplasmic dynamics of UV-induced apoptosis of cancer cells in the brain
Authors: Masashi Momiyama, Itaru Endo, Robert M. Hoffman
Journal: Cancer Research (2010)

Abstract We have developed a novel in vivo mouse model to image cancer cell nuclear-cytoplasmic dynamics in the brain in real-time and to visualize UV-C light killing of these cells. We used dual-color fluorescent cancer cells that express green fluorescent protein (GFP) linked to histone H2B in the nucleus and retroviral red fluorescent protein (RFP) in the cytoplasm. In order to visualize metastatic single cancer cell nuclear-cytoplasmic dynamics in the brain, dual-color Lewis Lung carcinoma (LLC) cells were injected into the right internal carotid artery of nude mice. A craniectomy open window was made over the right parietal bone. Metastatic dual-color LLC cells were irradiated with a 3.6-watt hand held UV-C light source for 60 seconds. The cells were then observed over 24 hours at 3 hour intervals through the open craniectomy window. The cancer cells were observed in the brain with the Olympus OV100 Small Animal Imaging System under high magnification. Metastatic dual-color LLC cells were visualized at the subcellular level in the brain enabling apoptosis to be imaged by nuclear morphology. UV-C light induced apoptosis of the dual-color LLC cells in the brain. Aggregation of chromatin at the nuclear membrane and fragmented nuclei of the cancer cell were followed in real time in the brain. More than 90% of the cancer cells irradiated with UV-C light died and disappeared without overt toxicity of the host. The novel mouse model used here will enable a deeper understanding of cancer cell dynamics in the brain. UV-C light may be a powerful tool for treatment of cancer cells expressing fluorescent reporters which now can be effected in vivo (Proc. Natl. Acad. Sci. USA, 1-6, 14514-14517, 2009 and Molecular Cancer Therapeutics 8, 3001-3008, 2009). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1314.
Endoscopic management of a rare cause of upper gastrointestinal bleeding: gastric polypoid extramedullary hemopoiesis
Authors: Paola Cognein, Valerio Belgrano, Luca Mastracci, Francesca Pitto, Alberto Fasoli, Franco De Cian, Federica Grillo
Journal: Endoscopy (2014)

Acute upper gastrointestinal hemorrhage remains a common emergency with annual incidence between 50 and 150 hospital accesses/100 000 population/year and a mortality rate of 7 – 10 % [1]. Endoscopy is the first option both in diagnosis and treatment.
Delayed Cerebellar Disease and Death after Accidental Exposure to Dimethylmercury
Authors: David W. Nierenberg, Richard E. Nordgren, Morris B. Chang, Richard W. Siegler, Michael B. Blayney, Fred Hochberg, Taft Y. Toribara, Elsa Cernichiari, Thomas Clarkson
Journal: New England Journal of Medicine (1998)

Ingestion of fish or grain contaminated with methylmercury resulted in epidemics of severe neurotoxicity and death in Japan in the 1950s and 1960s1 and in Iraq in 1972.2 The World Health Organization and other organizations have warned of the dangers of methylmercury compounds to the environment and to scientific researchers.1,3–6 Dimethylmercury may be even more dangerous than methylmercury compounds. The physical properties of dimethylmercury permit transdermal absorption, and the volatility of this liquid permits toxic exposure through inhalation. Since dimethylmercury is lethal at a dose of approximately 400 mg of mercury (equivalent to a few drops, or about . . .
Abstract 3398: High-throughput expression profiling of circulating tumor cells from breast cancer patients as potential therapy decision indicator
Authors: Katarina Kolostova, Marianna Romzova, Vladimir Bobek, Mikael Kubista, Sabine Kasimir-Bauer
Journal: Cancer Research (2012)

Abstract Background: The aim of this study was to assess the molecular profiles of circulating tumor cells (CTCs) from metastatic breast cancer (MBC) patients and to evaluate their potential as prognostic and therapy indicators. Methods: Blood samples (5ml) of 77 MBC patients from Czech and German Gynecological Cancer Centers were analyzed for CTCs using the AdnaTest BreastCancer (AdnaGen AG, Germany) for the detection of EpCAM, MUC-1 and HER-2 transcripts. Obtained cDNA molecules have been gene-specifically pre-amplified for multimarker qPCR analysis measured on Biomark® (Fludigm, USA) microfluidic chip for 48 samples and 48 testing positions (in total: 2304 rxn, 31 tumor specific-genes, 30 MBC samples, respectively). qPCR- results have been analyzed by GENEX v.s. 5.0 software (MultiD, SE). Results: CTCs were found in 42% of the MBC patients. Based on the AdnaTest, two distinct groups of CTC positive-MBC patients have been identified after principal component analysis of the gene expression data. The first CTC-positive group had relatively high EPCAM, MUC1, KRT19, HER2, AURKA, and MCM expression. In contrast, expression of PTEN, SATB1 and CD45 was low. The second CTC-positive group showed lower expressions of AURKA, EPCAM, and KRT19 than the first group. Furthermore, markers typically expressed in CD45 positive cells like SATB1, AKT, PARP, PTEN, mTOR, but also oncogene MYC and tumor suppressor TP53 were highly expressed in this group. The samples of CTC-negative MBC patients were characterized by low expression of the cancer phenotype associated genes EPCAM, KRT19, and MUC1, but showed comparably higher expression of genes associated with a stem cell like phenotype such as TWIST, ALDH1 and CD24. Conclusions: Based on our data, we conclude that CTCs enriched by the AdnaGen-technology are heterogeneous and do not necessarily express EPCAM. Even CTCs with low EPCAM expression but with elevated KRT19 and AURKA levels may represent a subgroup of high risk metastatic BC patients. Follow-up of the patients will show whether specific gene profiles of CTCs will a) identify responders and non-responders to breast cancer related therapies and b) be useful for personalized therapy of MBC in the future. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3398. doi:1538-7445.AM2012-3398
DETERMINATION OF QUANTITATIVE POST-SYSTOLIC STRAIN INDEX THRESHOLD ASSESSED BY TWO-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHY FOR DETECTION OF MYOCARDIAL ISCHEMIC SEGMENTS CONFIRMED ON INVASIVE FRACTIONAL FLOW RESERVE
Authors: Koya Ozawa, Nobusada Funabashi, Takeshi Nishi, Masayuki Takahara, Hiroyuki Takaoka, Yoshihide Fujimoto, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2015)