tbuckley/cabot-search huggingface dataset:
Low dose of fish oil in osteoarthritis: low effect?
Authors: X Chevalier, F Eymard
Journal: Annals of the Rheumatic Diseases (2016)

We read with great interest the results of the study from Hill et al ,1 on fatty acids diet (two regimens of fish oils: low and high daily dose) in patients with painful knee osteoarthritis (OA). As reported in the associated editorial letter from Felson et al ,2 this is an impressive work spanning over 2 years, which combines both clinical and MRI data. The authors should be congratulated for the quality of this trial. At the end, there is an unexpected effect of the lower dose of fish oil, which does better than the higher dose. We would like to share with the authors the following comments:

First, there is no control group and the outcome might be purely due …
Abstract 218: The new and rapid technique of detecting breast cancer cells using new fluorescent probe ‘gGlu-HMRG’ and its clinical application
Authors: Yoshiaki Shinden, Hiroki Ueo, Taro Tobo, Ayako Ganachi, Hisateru Komatsu, Sho Nambara, Tomoko Saito, Masami Ueda, Hidenari Hirata, Shotaro Sakimura, Yuki Takano, Ryutaro Uchi, Tomohiro Iguchi, Hidetoshi Eguchi, Keishi Sugimachi, Yoko Kubota, Yuichiro Kai, Yuko Kijima, Shoji Natsugoe, Hiraki Ueo, Yasuteru Urano, Koshi Mimori
Journal: Cancer Research (2015)

Abstract Method After spraying with gGlu-HMRG reagent to the samples, we took images within 5 minutes and analyzed the fluorescence intensity of them. Comparing the changes of fluorescence intensity and pathological evaluations, we examined how this fluorescent method could reflect the pathological status in resected breast tissues (n = 108 from 36 cases), margins of breast conserving surgery specimens (n = 7 from 5 cases) and axillary lymph nodes (n = 149 from 38 cases). Result 1. The sensitivity and specificity were 92% and 94% respectively for binary classification (normal / abnormal) of various breast tissues. 2. We could detect all malignant lesions in the surface of surgical margins of breast conserving surgery specimens. Additionally, we could detect large tumor-free lesions as fluorescent negative regions. 3. The sensitivity and specificity were 97% and 79% respectively for diagnosing metastatic and non-metastatic axillary lymph nodes. Discussion and conclusion It was well feasible to distinguish breast tumor tissues from normal surrounding tissues by this new method. Since it is simple and non-tissue-destructive, it could be readily adopted in the clinical setting. We anticipate that it will reduce costs and the burden on histopathology services in the intraoperative pathological diagnosis of breast conserving surgery and sentinel lymph node biopsy. This technical innovation enable us to visualize tumor cells in the body intraoperatively and evolve the cancer surgery that needs the complete resection of cancer cells. *1 Urano, Y. et al. Rapid cancer detection by topically spraying a γ-glutamyltranspeptidase-activated fluorescent probe. Sci. Trans. Med. 3, 110ra119 (2011). Citation Format: Yoshiaki Shinden, Hiroki Ueo, Taro Tobo, Ayako Ganachi, Hisateru Komatsu, Sho Nambara, Tomoko Saito, Masami Ueda, Hidenari Hirata, Shotaro Sakimura, Yuki Takano, Ryutaro Uchi, Tomohiro Iguchi, Hidetoshi Eguchi, Keishi Sugimachi, Yoko Kubota, Yuichiro Kai, Yuko Kijima, Shoji Natsugoe, Hiraki Ueo, Yasuteru Urano, Koshi Mimori. The new and rapid technique of detecting breast cancer cells using new fluorescent probe ‘gGlu-HMRG’ and its clinical application. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 218. doi:10.1158/1538-7445.AM2015-218
Fighting inequalities in AIDS treatment
Authors: Pat Sidley
Journal: BMJ (2002)

This paper presents the views of Edwin Cameron a South African Appeals Court judge and person living with AIDS who is considered to be an icon of resistance to the South African governments eccentric HIV/AIDS policies.  A long-time advocate for human rights and trade unions Judge Cameron’s profile was raised internationally during a speech at the International AIDS conference in Durban in July 2000 when he stated that South Africa’s growing AIDS epidemic is compounded by President Thabo Mbeki whose attitude he described as “irresponsibility that borders on criminality.” It is noted that Judge Cameron was moved to speak out on the issue of AIDS for the same reasons he was compelled to speak out against apartheid in the 1980s.
Mitoxantrone and mitomycin C as second-line treatment for advanced breast cancer
Authors: L. Repetto, L. Miglietta, G. Gardin, C. Naso, S. Giudici, L. Merlini, P. Queirolo, E. Campora, P. Pronzato, R. Rosso
Journal: Annals of Oncology (1992)
WITHDRAWN: Combinations of cyclodextrins and polyamidoamine dendrimer as a novel refolding system for protein
Authors: Taishi Higashi, Kanako Arima, Keiichi Motoyama, Hidetoshi Arima
Journal: Asian Journal of Pharmaceutical Sciences (2015)

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
Weekly cisplatin versus standard three-weekly cisplatin in concurrent chemoradiotherapy of head and neck cancer: Baskent University experience.
Authors: F. Kose, A. A. Besen, A. T. Sümbül, A. Sezer, C. Karadeniz, U. Disel, O. Altundag, O. Ozyilkan
Journal: Journal of Clinical Oncology (2011)

e16001 Background: Majority of patients with head and neck cancer present with locally advanced disease. Most of the patients are treated with concurrent chemoradiotherapy. However, the toxicities are substantial and can be associated with severe local and systemic toxicities. Alternate schedules of cisplatin have been tried to overcome these toxicities. No formal comparison, however, has been reported between alternate schedules and reference regimen in literature. The primary aim is to report a retrospective study comparing alternate schedule of cisplatin with standard three weekly bolus cisplatin in terms of effectiveness and related toxicities. Methods: Patients with head and neck cancers who were treated with concurrent chemoradiotherapy in our center between periods of 2007-2009 were retrospectively analyzed. Basic demographics and clinical characteristics’ of the patients were collected. Parameters such as overall survival rate, locoregional or systemic relapse rates, and time to local/systemic relapse, which show treatment effectiveness and also main toxicity, parameters were recorded. Results: Fifty five eligible patients were analyzed retrospectively. No significant difference was observed between the two groups of the study as compared to the median overall survival time. One, two, and three-year probability of survival for patients in groups A and B were 75% to 65% in one year, 63% to 56% in two year, and 63% to 52% in three year, respectively. Locoregional relapse and systemic relapse were similar in both groups. Although time to local and systemic relapse was higher in group B as compared to group A, a statistical analysis was failed to show any significant difference. Furthermore, there was no significant difference between groups with respect to major toxicities. Only development of grade III-IV mucositis during treatment showed significant effect on OS in univariate analysis. Conclusions: In patients with head and neck cancer, concurrent chemoradiotherapy with weekly cisplatin can be accepted as effective as concurrent chemoradiotherapy with three weekly high dose bolus cisplatin.
Depression in recently bereaved prepubertal children
Authors: R A Weller, E B Weller, M A Fristad, J M Bowes
Journal: American Journal of Psychiatry (1991)

The purpose of this study was to ascertain depressive symptoms in recently bereaved prepubertal children and compare these symptoms with those of depressed prepubertal children.The subjects were 38 children who had recently experienced the death of one but not both of their parents. They had to meet strict inclusion criteria so that the effects of bereavement per se, rather than other significant stressors, could be assessed. The comparison group consisted of 38 hospitalized, depressed children individually matched to each bereaved subject for age, sex, and socioeconomic status. All of the children underwent systematic and comprehensive evaluation. They and their parents were independently evaluated by trained interviewers using the parent and child versions of the Diagnostic Interview for Children and Adolescents. Family histories and basic demographic information were also obtained.The recently bereaved children endorsed many depressive symptoms. Thirty-seven percent of them met the DSM-III-R criteria for a major depressive episode. The depressed children, however, had more depressive symptoms on average than the bereaved children. The factors associated with increased depressive symptoms in the bereaved children were 1) the mother as the surviving parent, 2) preexisting untreated psychiatric disorder in the child, 3) family history of depression, and 4) high socioeconomic status.A considerable number of the bereaved children developed the clinical symptoms of a major depressive episode immediately after the death of a parent. The relation of these symptoms to the subsequent course of grief and to major depressive disorder remains unknown and should be studied further.
PTPS-06SINGLE-CELL TRANSCRIPTOME ANALYSIS IN PEDIATRIC HIGH-GRADE GLIOMA
Authors: Mariella G. Filbin, Itay Tirosh, Leah E. Escalante, Andrew S. Venteicher, Christine Hebert, Liliana Goumnerova, Keith L. Ligon, Todd Golub, Aviv Regev, Mario L. Suva
Journal: Neuro-Oncology (2015)

Human tumors are complex systems containing cells with diverse phenotypes, genotypes and epigenetic states; but current treatment strategies and models do not adequately reflect tumor composition in patients.High-grade gliomas are particularly heterogeneous tumors and currently represent the most common cause of cancer-related death in children.Increasing evidence indicates that treatment failure and resistance are at least in part due to this heterogeneity.We used single-cell RNA sequencing (scRNA-seq) to profile the transcriptome of thousands of single cells in pediatric high-grade glioma and reconstructed their cellular architecture.We found restricted expression of neural stem/progenitor expression programs in distinct subsets of cells, and observed that cellular programs evolve during genetic evolution.This suggests that both genetic and superimposed developmental programs contribute to tumor heterogeneity.These results provide unparalleled insight into the cellular composition of pediatric high-grade gliomas at the level of single-cell resolution, and open up new avenues for discovering novel therapeutic targets.Overall survival
Thank You to<i>JAMA Pediatrics</i>Authors, Peer Reviewers, and Readers
Authors: Frederick P. Rivara
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
A randomized phase II study comparing sequential versus simultaneous chemo-radiotherapy in patients with unresectable locally advanced squamous cell cancer of the head and neck
Authors: P. Pinnarò, M.C. Cercato, D. Giannarelli, P. Carlini, M.R. Del Vecchio, F. Ambesi Impiombato, F. Marzetti, M. Milella, F. Cognetti
Journal: Annals of Oncology (1994)
Abstract 3293: The Active Metabolite of Prasugrel Inhibits Platelet Procoagulant Activities
Authors: Andrew L Frelinger, Joseph A Jakubowski, YouFu Li, Marc R Barnard, Matthew D Linden, Inge Tarnow, Atsuhiro Sugidachi, Kenneth J Winters, Mark I Furman, Alan D Michelson
Journal: Circulation (2006)

Prasugrel is a novel prodrug of the same thienopyridine class as clopidogrel and ticlopidine. In vivo metabolism of prasugrel generates the active metabolite R-138727, an antagonist of the platelet...
Short Screening Tools for Cancer-Related Distress: A Review and Diagnostic Validity Meta-Analysis
Authors: Alex J. Mitchell
Journal: Journal of the National Comprehensive Cancer Network (2010)

Clinicians are increasingly seeking efficient methods to identify distress in cancer settings, using short screening tools with fewer than 14 items that take less than 5 minutes to complete. This article examines the value of these tools for identifying cancer-related distress, defined by semi-structured interview. An updated search, appraisal, and meta-analysis, with adjustments made for heterogeneity and underlying prevalence variations, identified 45 potentially useful short and ultra-short tools, although most were intended to help diagnose depression, with few targeted at distress (or anxiety). Very few studies attempted robust validation in cancer settings. When studies were limited to those tested against distress defined by semi-structured interview, only 6 methods had been validated, namely the Hospital Anxiety and Depression Scale (HADS; 13 studies, 14 items), the Distress Thermometer (DT; 4 studies, 1 item), a single verbal question (4 studies, 1 item), the Psychological Distress Inventory (PDI; 1 study, 13 items), combined DT and an impact thermometer (1 study, 2 items), and combined 2 verbal questions (1 study, 2 items). Comparing these 6 approaches side-by-side suggests that for screening, all tools have approximately the same accuracy. Therefore, choice of a short screening tool for distress can be based on acceptability or cost-effectiveness. Here, best evidence supports use of the DT or single verbal question. Remarkably, the overall accuracy of these single-item approaches seems comparable to that of the 14-item HADS (total score), whereas their efficiency is superior. For case-finding, data are sparse but no method seems to be entirely satisfactory. Current evidence suggests that the optimal short methods for identifying distress are 2 verbal questions or PDI. Of these approaches, the 2 verbal questions has superior efficiency. All short methods may be augmented by repeated application, an assessment of unmet needs (problem list), and clarification regarding the need for professional help. No screening tool should be seen as an alternative to careful clinical assessment and management. Despite much interest in the development of short and ultra-short tools, data on validation and implementation are currently incomplete. Nevertheless, short methods seem to be at least as successful as the HADS, although substantially more efficient and hence more acceptable, and therefore may be a suitable initial method of assessment in busy clinical settings.
Integrating biomarkers into clinical predictive and prognostic paradigms for prostate cancer: The role of p53 status
Authors: M. A. Ritter, K. W. Gilchrist, D. F. Jarrard, B. M. Verhoven
Journal: Journal of Clinical Oncology (2004)

9604 Background: Prognostic groupings using PSA, grade and stage still leave significant unexplained outcome variability. Biological heterogeneity is likely a factor, emphasizing the importance of integrating biomarker data into predictive and prognostic paradigms. Novel therapy targeting options might also be identified along the way. The status of one such biomarker, p53, could alter curative-intent radiotherapy outcomes based on its position in radioresponse pathways. We therefore identified a cohort of low-to-moderate risk, previously-treated radiotherapy patients and determined PSA failure rates as a function of pretreatment p53 tumor status. A prognostically matched surgery group was studied in parallel to test whether p53 had true predictive specificity for radiation outcome or was only a global prognostic factor. Methods: A total of 81 and 53 patients were identified who previously underwent a radical prostatectomy or radiotherapy(68–70 Gy), respectively, and who shared similarly favorable characteristics (PSA ≤ 20 ng/ml, Gleason score ≤ 7; no hormonal therapy before failure; 6 yr median follow-up). Abnormal p53 status (≥ 10% labeling index) was determined immunohistochemically in pretreatment biopsy specimens. Results: About 34% of both surgery and radiation patient biopsy specimens had abnormal p53 labeling. The two groups had very similar 5-year actuarial PSA failure rates of about 31%. Multivariate analyses including stage, grade and initial PSA revealed that abnormal p53 strongly correlated with actuarial PSA failure in radiotherapy (hazard ratio of 4.6; p < 0.001), but not in surgery patients (hazard ratio of 2.14; p = 0.22). Conclusions: Abnormal pretreatment p53 status in favorable patients strongly and independently predicted for PSA failure after radiotherapy but not radical prostatectomy. This radiation-specific predictive power for outcome, if further validated, could significantly influence patient management. Beyond simple stratification, pretreatment p53 testing could identify a role for altered treatment - perhaps aggressive dose escalation or a novel p53 targeting strategy. No significant financial relationships to disclose.
Pyogenic Osteomyelitis of the Spine
Authors: P. Martin
Journal: BMJ (1946)

To demonstrate this the following technique was used.An all-glass 2-ml.syringe with a No. 23 needle attached was filled with normal saline and a tiny drop of citrated blood (as used for estimation of sedimentation rate by the Westergren method) was placed on the tip of the needle by means of a Pasteur pipette.After an interval varying from 15 to 60 seconds the needle was cut off at the socket with wire-cutters, the socket removed from the syringe, and the drop of saline on the tip of the syringe examined for red cells.It was found that contamination could occur in 45 seconds, as the results shown in Table VI demonstrate.TABLE VI.-Spread of Red Cells AlonIg the Needle Towards the Syringe Time Tnterval between No. of Red Cells in 0 9 c.mm. of Saline in Drop Application of Red Cells at Tip of Syringe and Cutting the Needle Expt. 1 Expt. 2 Expt. 3 Expt. 4Expt. 515 secs.0
8Cl-cAMP Cytotoxicity in Both Steroid Sensitive and Insensitive Multiple Myeloma Cell Lines Is Mediated by 8Cl-Adenosine
Authors: Robert G. Halgren, Ann E. Traynor, Shafali Pillay, Joann L. Zell, Kimberly F. Heller, Nancy L. Krett, Steven T. Rosen
Journal: Blood (1998)
Abstract 18603: Estrogen Plays a Protective Role in Advanced Heart Failure by Regulating Target Genes of miR-129-5p Suppressing Cardiac Fibrosis
Authors: Salil Sharma, Andrea Iorga, Rangarajan D Nadadur, Mansoureh Eghbali
Journal: Circulation (2012)

Background: Moderate cardiac fibrosis has been reported in advanced heart failure (HF) induced by pressure overload in mice. We have previously shown that short term estrogen(E2) therapy starting after the advanced HF can rescue HF. E2 has been shown to reverse fibrosis through estrogen receptor beta(ERb). Here, we explored whether E2 can suppress cardiac fibrosis by inducing miR-129-5p expression through ERb mediated mechanism and verified its key target genes. Methods and results: We used transaortic constriction to induce HF in male mice, and once the ejection fraction (EF) reached ∼30%, one group of animals was sacrificed (HF group), and the other group received 17b-estradiol via a subcutaneous pellet implant (0.012mg/pellet, n=16) (E2 group) for 10 days. Sham-operated mice served as CTRL. Serial echocardiography was performed to monitor cardiac structure and function. Short-term E2 treatment rescued pressure overload-induced decompensated HF in mice by restoring the EF from 33.17±1.12% to 53.05±1.29(p &lt;0.001). E2 also decreased both interstitial and prevascular fibrosis in HF. MicroRNA microarray analysis and qPCR validation revealed that miR-129-5p is upregulated ∼2 fold in E2 group compared to HF group. Interestingly, miR-129-5p showed no significant change in E2 versus CTRL suggesting altered miR-129-5p expression in HF was restored to CTRL group by E2 treatment. Treatment of HF with ERb agonist (DPN), but not ER-alpha agonist (PPT), also resulted in the upregulation of miR-129-5p indicating the estrogen mediated induction of miR-129-5p is possibly mediated through ERb. In vitro, angiotensin II treatment significantly downregulated miR-129-5p expression in fibroblasts which was restored by estrogen and DPN but not by ERb antagonist (PHPT) further confirming the role of ERb in regulating miR-129-5p. In vitro, over-expression of miR129-5p in fibroblasts resulted in the significant down-regulation of many potential pro-fibrotic target genes including COL1A, PDGFA, GREM1 and the transcription factor SOX4. Conclusion: Our data strongly suggests that estrogen treatment during HF induces miR-129-5p likely through ERb. Mechanistically, miR-129-5p represses fibrosis by targeting key component genes associated with cardiac fibrosis.
Treatment of Newly Diagnosed Glioblastoma Multiforme
Authors: Carsten Nieder
Journal: Journal of Clinical Oncology (2002)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.14.3179 Journal of Clinical Oncology - published online before print November 1, 2016 PMID: 12118034 Treatment of Newly Diagnosed Glioblastoma Multiforme Carsten NiederxCarsten NiederSearch for articles by this author Show More Technical University Munich, Munich, Germany https://doi.org/10.1200/JCO.2002.20.14.3179 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
Primary prevention in perspective
Authors: H R Lamb, J Zusman
Journal: American Journal of Psychiatry (1979)

Discussion of primary prevention has been made difficult by lack of clarity of underlying concepts and assumptions. Is the purpose to prevent diagnosable mental illness or to prevent unhappiness and social incompetence? What are the implications of the assumption that societal stress causes mental illness? Is there a clear distinction made between major and minor mental illness? Except for a few specific conditions there is little evidence that primary prevention has been effective. The authors feel that research and program evaluation in prevention is sorely needed but should be funded separately and with discretion. Scarce mental health funds should not be diverted from direct treatment for this purpose.