FATAL TOXIC ENCEPHALITIS OCCURRING DURING IPRONIAZID THERAPY IN PULMONARY TUBERCULOSIS
Authors: R S MITCHELL
Journal: Annals of Internal Medicine (1955)

Case Reports1 February 1955FATAL TOXIC ENCEPHALITIS OCCURRING DURING IPRONIAZID THERAPY IN PULMONARY TUBERCULOSISROGER S. MITCHELL, M.D., F.A.C.P.ROGER S. MITCHELL, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-2-417 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIproniazid (the isopropyl derivative of isonicotinic acid hydrazine, "Marsilid"†) was first made available for trial in patients with tuberculosis in June, 1951.1During the first six months of its use iproniazid was found to be less tuberculostatic than isoniazid in vitro,2but possibly more effective in relieving tuberculotoxicity than isoniazid in vivo.1, 3Untoward effects were much more common with iproniazid than with isoniazid.1, 3, 4, 5, 6, 7While the drug has now been withdrawn from any use in patients because of these side effects, especially of the central nervous system,3, 5, 7, 8no deaths attributed to iproniazid...Bibliography1. SelikoffRobitzek IJEH: Tuberculosis chemotherapy with hydrazine derivatives of isonicotinic acid, Dis. of Chest 21: 3, 1952. Google Scholar2. SteenkenWolinsky WE: Antituberculous properties of hydrazine of isonicotinic acid (Rimifon, Marsilid), Am. Rev. Tuberc. 65: 365, 1952. MedlineGoogle Scholar3. BlochDooneiefBuchbergSpellman RGASASS: The clinical effect of isoniazid and iproniazid in the treatment of pulmonary tuberculosis, Ann. Int. Med. 40: 881, 1954. LinkGoogle Scholar4. SelikoffRobitzekOrnstein IJEHGG: Toxicity of hydrazine derivatives of isonicotinic acid in the chemotherapy of human tuberculosis, Quart. Bull., Sea View Hosp. 13: 17, 1952. Google Scholar5. BensonStefkoRoe WMPLMD: Pharmacologic and toxicologic observations on hydrazine derivatives of isonicotinic acid (Rimifon, Marsilid), Am. Rev. Tuberc. 65: 376, 1952. MedlineGoogle Scholar6. RobitzekSelikoff EHIJ: Hydrazine derivatives of isonicotinic acid (Rimifon, Marsilid) in the treatment of active progressive caseous-pneumonic tuberculosis, Am. Rev. Tuberc. 65: 402, 1952. MedlineGoogle Scholar7. SelikoffRobitzekOrnstein IJEHGG: Treatment of pulmonary tuberculosis with hydrazide derivatives of isonicotinic acid, J. A. M. A. 150: 973, 1952. CrossrefMedlineGoogle Scholar8. Hunter RA: Confusional psychosis with residual organic cerebral impairment following isoniazid therapy, Lancet 2: 960, 1952. CrossrefMedlineGoogle Scholar9. BiehlNimitz JPHJ: Studies on the use of a high dose of isoniazid. I. Toxicity studies, Am. Rev. Tuberc. 70: 430, 1954. MedlineGoogle Scholar10. SmithPhillipScheel HWCLD: The interchange of isonicotinic acid hydrazide and nicotinamide by a human lung DPNase, in preparation. Google Scholar11. Patiala J: The amount of pyridine nucleotides (coenzymes I & II) in blood in experimental tuberculosis before and during isoniazid treatment, Am. Rev. Tuberc. 70: 453, 1954. MedlineGoogle Scholar12. Cruikshank EK: Vitamins and hormones, Vol. 10, 1952, Academic Press, Inc., New York, pp. 2-42. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROGER S. MITCHELL, M.D., F.A.C.P.Affiliations: Trudeau, N. Y.*Received for publication September 20, 1954.From Trudeau Sanatorium of the Trudeau-Saranac Institute, Trudeau, N. Y.†The iproniazid (1-isonicotinyl; 2-isopropylhydrazine) used in this case was kindly provided by Hoffmann-LaRoche, Inc., Nutley, N. J. 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