Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia
Authors: JOHN M. BENNETT
Journal: Annals of Internal Medicine (1985)

Position Papers1 October 1985Proposed Revised Criteria for the Classification of Acute Myeloid LeukemiaA Report of the French-American-British Cooperative GroupJOHN M. BENNETT, M.D., DANIEL CATOVSKY, M.D., MARIE T. DANIEL, M.D., GEORGE FLANDRIN, M.D., DAVID A. G. GALTON, M.D., HARVEY R. GRALNICK, M.D., CLAUDE SULTAN, M.D.JOHN M. BENNETT, M.D.Search for more papers by this author, DANIEL CATOVSKY, M.D.Search for more papers by this author, MARIE T. DANIEL, M.D.Search for more papers by this author, GEORGE FLANDRIN, M.D.Search for more papers by this author, DAVID A. G. GALTON, M.D.Search for more papers by this author, HARVEY R. GRALNICK, M.D.Search for more papers by this author, CLAUDE SULTAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-4-620 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe first proposals for the morphologic classification of the acute leukemias by the French-American-British (FAB) group (1) were put forward in the hope that they might serve as a basis for a generally acceptable system of classification. Such a system would permit comparisons between series of cases, show prognostic differences between different categories, and provide a framework of reference for persons working in different biological disciplines who use material from patients with leukemia.In the last 7 years the FAB proposals have been accepted by many groups involved in cooperative clinical trials with both acute myeloid leukemia and acute lymphoblastic...References1. BENNETTCATOVSKYDANIEL JDM. Proposals for the classification of the acute leukaemias: French-American-British Cooperative Group. Br J Haematol. 1976;33:451-8. CrossrefMedlineGoogle Scholar2. SECOND INTERNATIONAL WORKSHOP ON CHROMOSOMES IN LEUKEMIA, 1979. Morphological analysis of acute promyelocytic (M3) and t(8;21). Cancer Genet Cytogenet. 1980;2:97-8. CrossrefGoogle Scholar3. THIRD INTERNATIONAL WORKSHOP ON CHROMOSOMES IN LEUKEMIA, 1980. Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia. Cancer Genet Cytogenet. 1981;4:111-37. CrossrefMedlineGoogle Scholar4. FOURTH INTERNATIONAL WORKSHOP ON CHROMOSOMES IN LEUKEMIA, 1982. A prospective study of acute non-lymphocytic leukemia: correlation of morphology and karyotype. Cancer Genet Cytogenet. 1984;11:246-360. Google Scholar5. MERTELSMANNTZVI THALERLO RHT. Morphological classification, response to therapy and survival in 263 adult patients with acute nonlymphoblastic leukemia. Blood. 1980;56:773-81. CrossrefMedlineGoogle Scholar6. VAN RHENENVERHULSTHUIJGENSLANGENHUIJSEN DJPM. Maturation index: a contribution to quantification in the FAB classification of acute leukemia. Br J Haematol. 1980;46:581-6. CrossrefMedlineGoogle Scholar7. STAVEM P. The blasted immature cells in the bone marrow [Letter]. Scand J Haematol. 1983;30:492-3. CrossrefMedlineGoogle Scholar8. AMAKIHATTORIBENNETT IKJ. FAB classification of acute leukemias correlating with response to chemotherapy. Nippon Ketsueki Gakkai Zasshi. 1984;47:206-38. MedlineGoogle Scholar9. BENNETTCATOVSKYDANIEL JDM. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations. Br J Haematol. 1981;47:553-61. CrossrefMedlineGoogle Scholar10. BENNETTCATOVSKYDANIEL JDM. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189-99. CrossrefMedlineGoogle Scholar11. SULTANDEREGNAUCOURTKO CJY. Distribution of 250 cases of acute myeloid leukaemia (AML) according to the FAB classification and response to therapy. Br J Haematol. 1981;47:545-51. CrossrefMedlineGoogle Scholar12. BENNETTCATOVSKYDANIEL JDM. A variant form of hypergranular promyelocytic leukaemia (M3) [Letter]. Br J Haematol. 1980;44:169-70. CrossrefMedlineGoogle Scholar13. YAMLICROSBY LCW. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971;55:283-90. CrossrefMedlineGoogle Scholar14. PARRYCHANDANSHAHANI RRK. A rapid and sensitive assay for muramidase. Proc Soc Exp Biol Med. 1965;119:384-6. CrossrefMedlineGoogle Scholar15. LEDER L. Akute myelo-monozytare Leukamie mit atypischen Naphthol-AS-D-Chloroacetat-Esterase-positivenEosinophilen. Acta Haematol. 1970;44:52-62. CrossrefMedlineGoogle Scholar16. BERGERBERNHEIMDANIELVALENSIFLANDRIN RAMFG. t(15;17) translocation in acute promyelocytic leukaemia (M3) and cytological "M3-variant." Nouv Rev Fr Hematol. 1981;23:27-38. Google Scholar17. BERGERBERHEIMDANIELVALENSISIGAUXFLANDRIN RAMFFG. Cytologic characterization and significance of normal karyotypes in t(8;21) acute myeloblasts leukemia. Blood. 1982;59:171-8. CrossrefMedlineGoogle Scholar18. BERGERBERNHEIMSIGAUXDANIELVALENSIFLANDRIN RAFMFG. Acute monocytic leukemia chromosome studies. Leuk Res. 1982;6:17-26. CrossrefMedlineGoogle Scholar19. GOLOMBROWLEYVARDIMANTESTABUTLER HJJJA. "Microgranular" acute promyelocytic leukemia: a distinct clinical, ultrastructural, and cytogenetic entity. Blood. 1980;55:253-9. CrossrefMedlineGoogle Scholar20. OSHIMURAOHYASHIKIMORITERADATAKAKU MKMHF. Cytogenetic and hematologic findings in acute myelogenous leukemia, M2 according to the FAB classification. Gann. 1982;73:212-6. MedlineGoogle Scholar21. ARTHURBLOOMFIELD DC. Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association. Blood. 1983;61:994-8. CrossrefMedlineGoogle Scholar22. LE BEAULARSONBITTERVARDIMANGOLOMBROWLEY MRMJHJ. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. N Engl J Med. 1983;309:603-6. CrossrefGoogle Scholar23. DEN OTTOLANDERTE VELDEBREDEROO GJP. Megakaryoblastic leukaemia (acute myelofibrosis): a report of three cases. Br J Haematol. 1979;42:9-20. CrossrefMedlineGoogle Scholar24. BRETON-GORIUSGOURDINREYES JMF. Ultrastructure of the leukemic cell. In: CATOVSKY D, ed. The Leukemic Cell. Edinburgh, Scotland: Churchill Livingstone; 1981:87-128. Google Scholar25. BAINCATOVSKYO'BRIEN BDM. Megakaryoblastic leukemia presenting as acute myelofibrosis—a study of four cases with the platelet-peroxidase reaction. Blood. 1981;58:206-13. CrossrefMedlineGoogle Scholar26. SULTANSIGAUXIMBERTREYES CFMF. Acute myelodysplasia with myelofibrosis: a report of eight cases. Br J Haematol. 1981;49:11-6. CrossrefMedlineGoogle Scholar27. VAN DER REIJDENVAN RHENENLANSDORP HDP. A comparison of surface marker analysis and FAB classification in acute myeloid leukemia. Blood. 1983;61:443-8. CrossrefMedlineGoogle Scholar28. VAINCHENKERDESCHAMPSBASTIN WJJ. Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemia patients. Blood. 1982;59:514-21. CrossrefMedlineGoogle Scholar29. NEEDLEMANBURNSDICKARMITAGE SCFJ. Hypoplastic acute leukemia. Cancer. 1981;48:1410-4. CrossrefMedlineGoogle Scholar30. HOWEBLOOMFIELDMCKENNA RCR. Hypocellular acute leukemia. Am J Med. 1982;72:391-5. CrossrefMedlineGoogle Scholar31. CATOVSKYDECARDULLOO'BRIEN DSLM. Cytochemical markers of differentiation in acute leukemia. Cancer Res. 1981;41( 11 pt 2):4824-32. MedlineGoogle Scholar32. PARKINARTHURABRAMSON JDC. Acute leukemia associated with the t(4;11) chromosome rearrangement: ultrastructural and immunologic characteristics. Blood. 1983;119:1321-31. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York; London England Paris and Creteil France Bethesda Maryland▸From the University of Rochester Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, New York; Medical Research Council Leukaemia Unit, Royal Postgraduate Medical School, London, England; Institut de Recherches sur les Leucemies et les Maladies du Sang, Hopital Saint-Louis, Paris, France; Hematology Service, National Institutes of Health, Bethesda, Maryland; and Service Central d'Hematologie-Immunologie, Hopital Henri Mondor, Creteil, France. 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