tbuckley/cabot-search huggingface dataset:
Relationship of Late Loss in Lumen Diameter to Coronary Restenosis in Sirolimus-Eluting Stents
Authors: Laura Mauri, E. John Orav, A. James O’Malley, Jeffrey W. Moses, Martin B. Leon, David R. Holmes, Paul S. Teirstein, Joachim Schofer, Günter Breithardt, Donald E. Cutlip, Dean J. Kereiakes, Chunxue Shi, Brian G. Firth, Dennis J. Donohoe, Richard E. Kuntz
Journal: Circulation (2005)

Observed rates of restenosis after drug-eluting stenting are low (<10%). Identification of a reliable and powerful angiographic end point will be useful in future trials.Late loss (postprocedural minimum lumen diameter minus 8-month minimum lumen diameter) was measured in the angiographic cohorts of the SIRIUS (n=703) and E-SIRIUS (n=308) trials. Two techniques, the standard normal approximation and an optimized power transformation, were used to predict binary angiographic restenosis rates and compare them with observed restenosis rates. The mean in-stent late loss observed in the SIRIUS trial was 0.17+/-0.45 mm (sirolimus) versus 1.00+/-0.70 mm (control). If a normal distribution was assumed, late loss accurately estimated in-stent binary angiographic restenosis for the control arm (predicted 35.4% versus observed 35.4%) but underestimated it in the sirolimus arm (predicted 0.6% versus observed 3.2%). Power transformation improved the reliability of the estimate in the sirolimus arm (predicted 3.2% [CI 1.0% to 6.7%]) with similar improvements in the E-SIRIUS trial (predicted 4.0% [CI 1.2% to 7.0%] versus observed 3.9%). In the sirolimus-eluting stent arm, in-stent late loss correlated better with target-lesion revascularization than in-segment late loss (c-statistic=0.915 versus 0.665).Because distributions of late loss with a low mean are right-skewed, the use of a transformation improves the accuracy of predicting low binary restenosis rates. Late loss is monotonically correlated with the probability of restenosis and yields a more efficient estimate of the restenosis process in the era of lower binary restenosis rates.
Long-term immune reconstitution in RAG-1-deficient mice treated by retroviral gene therapy: a balance between efficiency and toxicity
Authors: Chantal Lagresle-Peyrou, Frank Yates, Michèle Malassis-Séris, Christophe Hue, Estelle Morillon, Alexandrine Garrigue, Allen Liu, Philippe Hajdari, Daniel Stockholm, Olivier Danos, Brigitte Lemercier, Marie-Lise Gougeon, Frederic Rieux-Laucat, Jean-Pierre de Villartay, Alain Fischer, Marina Cavazzana-Calvo
Journal: Blood (2005)
Maternal vitamin A deficiency and mother-to-child transmission of HIV-1
Authors: R.D Semba, J.D Chiphangwi, P.G Miotti, G.A Dallabetta, D.R Hoover, J.K Canner, Aj Saah
Journal: The Lancet (1994)

Studies show that around 10-40% HIV-positive women will give birth to children who are also infected. However, the risk factors for transmission from mother to child are not well understood and the effects of maternal nutritional status are unknown. We conducted a study of vitamin A status in pregnant women as a risk factor for mother-to-child transmission of HIV in Malawi. Serum vitamin A, height, weight, CD4 T-cell counts, and duration of breastfeeding were measured in 338 HIV-positive mothers whose infant's HIV serostatus was known. Mother-to-child transmission of HIV was 21.9% among mothers whose infants survived to 12 months of age. Mean vitamin A concentration in 74 mothers who transmitted HIV to their infants was lower than that in 264 mothers who did not transmit HIV to their infants (0.86 [0.03] vs 1.07 [0.02], p < 0.0001). We divided HIV positive mothers to 4 groups, those with vitamin A concentrations of less than 0.70, between 0.70 and 1.05, between 1.05 and 1.40, and greater than or equal to 1.40 mumol/L. The mother-to-child transmission rates for each group were 32.4%, 26.2%, 16.0%, and 7.2%, respectively (p < 0.0001). Maternal CD4 cell counts, CD4%, and CD4/CD8 ratio were also associated with increased mother-to-child transmission of HIV. Maternal age, body-mass index, and breastfeeding practices were not significantly associated with higher mother-to-child transmission. Our study suggests that maternal vitamin A deficiency contributes to mother-to-child transmission of HIV.
Measuring Trauma and Health Status in Refugees
Authors: Michael Hollifield, Teddy D. Warner, Nityamo Lian, Barry Krakow, Janis H. Jenkins, James Kesler, Jayne Stevenson, Joseph Westermeyer
Journal: JAMA (2002)

Refugees experience multiple traumatic events and have significant associated health problems, but data about refugee trauma and health status are often conflicting and difficult to interpret.To assess the characteristics of the literature on refugee trauma and health, to identify and evaluate instruments used to measure refugee trauma and health status, and to recommend improvements.MEDLINE, PsychInfo, Health and PsychoSocial Instruments, CINAHL, and Cochrane Systematic Reviews (searched through OVID from the inception of each database to October 2001), and the New Mexico Refugee Project database.Key terms and combination operators were applied to identify English-language publications evaluating measurement of refugee trauma and/or health status.Information extracted for each article included author; year of publication; primary focus; type (empirical, review, or descriptive); and type/name and properties of instrument(s) included. Articles were excluded from further analyses if they were review or descriptive, were not primarily about refugee health status or trauma, or were only about infectious diseases. Instruments were then evaluated according to 5 criteria (purpose, construct definition, design, developmental process, reliability and validity) as described in the published literature.Of 394 publications identified, 183 were included for further analyses of their characteristics; 91 (49.7%) included quantitative data but did not evaluate measurement properties of instruments used in refugee research, 78 (42.6%) reported on statistical relationships between measures (presuming validity), and 14 (7.7%) were only about statistical properties of instruments. In these 183 publications, 125 different instruments were used; of these, 12 were developed in refugee research. None of these instruments fully met all 5 evaluation criteria, 3 met 4 criteria, and 5 met only 1 of the criteria. Another 8 standard instruments were designed and developed in nonrefugee populations but adapted for use in refugee research; of these, 2 met all 5 criteria and 6 met 4 criteria.The majority of articles about refugee trauma or health are either descriptive or include quantitative data from instruments that have limited or untested validity and reliability in refugees. Primary limitations to accurate measurement in refugee research are the lack of theoretical bases to instruments and inattention to using and reporting sound measurement principles.
MicroRNA Molecular Profiles Associated with Diagnosis, Clinicopathologic Criteria, and Overall Survival in Patients with Resectable Pancreatic Ductal Adenocarcinoma
Authors: Nigel B. Jamieson, Douglas C. Morran, Jennifer P. Morton, Asif Ali, Euan J. Dickson, C. Ross Carter, Owen J. Sansom, T.R. Jeffry Evans, Colin J. McKay, Karin A. Oien
Journal: Clinical Cancer Research (2011)

MicroRNAs (miRNA) have potential as diagnostic and prognostic biomarkers and as therapeutic targets in cancer. We sought to establish the relationship between miRNA expression and clinicopathologic parameters, including prognosis, in pancreatic ductal adenocarcinoma (PDAC).
Psychomotor Activity and Cerebrospinal Fluid Amine Metabolites in Affective Illness
Authors: ROBERT M. POST, JOEL KOTIN, FREDERICK K. GOODWIN, EDNA K. GORDON
Journal: American Journal of Psychiatry (1973)

In order to evaluate the effect of psychomotor activity on CSF amine metabolites, lumbar punctures were performed after moderately depressed patients had simulated manic hyperactivity for four hours. The CSF levels of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were significantly higher after simulated mania or exercise alone than in the same patients after bed rest. In addition, there was a trend for levels of 3-methoxy-4-hydroxyphenylglycol to increase with activity. The levels of 5-HIAA and HVA correlated with the amount of motor activity: lowest in depression, intermediate in mania and hypomania, and highest in simulated mania. Both metabolites were higher in severe mania than in hypomania. These results suggest that psychomotor activity is an important determinant of CSF amine metabolite levels in affective illness.
A three-week schedule of gemcitabine–cisplatin in advanced non-small-cell lung cancer with two different cisplatin dose levels: A phase II randomized trial
Authors: M. Rinaldi, L. Crinò, G.V. Scagliotti, A.M. Mosconi, F. De Marinis, C. Gridelli, G. Selvaggi, M. Della Giulia, S. Darwish, S. Porrozzi, S. Novello, A. Cipri, R. Bartolucci, C. Calandri, M. Tonato
Journal: Annals of Oncology (2000)
Knee arthropathy secondary to Mycobacterium scrofulaceum.
Authors: J Molony, K Connolly
Journal: Annals of the Rheumatic Diseases (1973)

Atypical mycobacteria have been described as long as 36 years ago, but it has only been in the last 10 years that the ability of these organisms to cause disease in man has been recognized.The most common patho- logical processes with which the atypical myco- bacteria are associated occur in the lungs and in the cervical lymph nodes.More rare is joint pathology.We describe here a case of knee arthritis with culture of Mycobacterium scrofulaceum from the synovial fluid. Case ReportA 47-year-old nun who had had no significant medical or surgical history up to August, 1970, then noted a tender swelling on both sides of her neck near the angle of the jaw.No definite reason was found for this lymphadenopathy and the swellings subsided spontaneously.In September, 1970, both knees became painful, stiff, and swollen.The arthropathy continued in status quo up to June, 1971, when we first saw her.
Gender-related changes in the practice and outcomes of percutaneous coronary interventions in northern New England from 1994 to 1999
Authors: David J Malenka, David E Wennberg, Hebe A Quinton, Daniel J O’Rourke, Paul D McGrath, Samuel J Shubrooks, Gerry T O’Connor, Thomas J Ryan, John F Robb, Mirle A Kellett, William A Bradley, Michael A Hearne, Peter N VerLee, Matthew W Watkins, Bruce D Hettleman, Winthrop D Piper
Journal: Journal of the American College of Cardiology (2002)
Asthma in the transition from childhood to adulthood
Authors: G Russell
Journal: Thorax (2002)

Both the prognosis of childhood asthma and the incidence of asthma in early adulthood are strongly influenced by bronchial hyperreactivity, a measurement few of us make routinely.

One of the most neglected aspects of the epidemiology of asthma is the period of transition from childhood to adulthood, perhaps because paediatricians feel insecure about trespassing on adult territory and adult physicians do not have access to paediatric cohorts. Adolescence is, in fact, an important period for asthmatic patients, not only because the condition itself may be difficult to manage, but because this is a time when asthma sometimes remits1–3 and when the male preponderance of childhood gradually gives way to the female preponderance of adulthood.4,5

Numerous cross sectional studies have spanned this period. Secondary schools provide a captive population of adolescents and have been widely used in the ISAAC studies,6 and college students7,8 and army recruits9,10 provide ready sources of young adults for study. However, although such cross sectional studies demonstrate very clearly that adolescence is a time when significant changes occur in the asthmatic population, they cannot examine the factors that might influence the prognosis of …
Molecular basis of EEC (ectrodactyly, ectodermal dysplasia, clefting) syndrome: five new mutations in the DNA-binding domain of the <i>TP63</i> gene and genotype-phenotype correlation
Authors: S.E. Clements, T. Techanukul, D. Coman, J.E. Mellerio, J.A. McGrath
Journal: British Journal of Dermatology (2009)

Journal Article Molecular basis of EEC (ectrodactyly, ectodermal dysplasia, clefting) syndrome: five new mutations in the DNA‐binding domain of the TP63 gene and genotype–phenotype correlation Get access S.E. Clements, S.E. Clements Genetic Skin Disease Group, St John's Institute of Dermatology, King's College London (Guy's Campus), London, U.K. Search for other works by this author on: Oxford Academic Google Scholar T. Techanukul, T. Techanukul Genetic Skin Disease Group, St John's Institute of Dermatology, King's College London (Guy's Campus), London, U.K. Search for other works by this author on: Oxford Academic Google Scholar D. Coman, D. Coman Royal Children's Hospital, Victoria 3052, Australia Search for other works by this author on: Oxford Academic Google Scholar J.E. Mellerio, J.E. Mellerio Genetic Skin Disease Group, St John's Institute of Dermatology, King's College London (Guy's Campus), London, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.A. McGrath J.A. McGrath Genetic Skin Disease Group, St John's Institute of Dermatology, King's College London (Guy's Campus), London, U.K. John A. McGrath. E‐mail: john.mcgrath@kcl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 1, 1 January 2010, Pages 201–207, https://doi.org/10.1111/j.1365-2133.2009.09496.x Published: 01 January 2010
Language and Other Factors Associated With Foot Self-Management Among Puerto Ricans With Diabetes in New York City
Authors: Akiko S. Hosler, Thomas A. Melnik
Journal: Diabetes Care (2006)

Daily self-inspection of feet for sores and irritations is an essential and cost-effective diabetes self-management practice to prevent foot complications (1,2). It is relatively easy to perform and does not require equipment or supplies, yet nearly 40% of people with diabetes in New York state do not practice daily foot inspection, and Hispanics are the least likely to do so (3). Puerto Ricans are the largest Hispanic group in the state and have a markedly high prevalence of diabetes (4,5). Studies have found that Puerto Ricans show poor overall self-management of diabetes (6,7) and suffer from a high prevalence of foot complications (8–10). Poor English skills are often identified as a major reason for their suboptimal self-care practice (11,12), but some studies concluded that language may not be a barrier (13,14). The present study examines factors associated with Puerto Ricans’ daily foot self-inspection practice using population-based survey data.

The data were collected in 2000–2001 through a random digit–dialing telephone survey aimed to reach Puerto Rican adults (≥18 years of age) residing in New York City (5). The survey protocol and questions were taken from the Behavioral Risk Factor Surveillance System developed by the Centers for Disease Control and Prevention (15). Those who responded affirmatively to the question “Have you been told by your doctor that …
<i>PIK3CA</i> Mutations and Copy Number Gains in Human Lung Cancers
Authors: Hiromasa Yamamoto, Hisayuki Shigematsu, Masaharu Nomura, William W. Lockwood, Mitsuo Sato, Naoki Okumura, Junichi Soh, Makoto Suzuki, Ignacio I. Wistuba, Kwun M. Fong, Huei Lee, Shinichi Toyooka, Hiroshi Date, Wan L. Lam, John D. Minna, Adi F. Gazdar
Journal: Cancer Research (2008)

We investigated the frequency and function of mutations and increased copy number of the PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene changes present in human cancers. We analyzed the mutational status of exons 9 and 20 and gene copy number of PIK3CA using 86 non-small cell lung cancer (NSCLC) cell lines, 43 small cell lung cancer (SCLC) cell lines, 3 extrapulmonary small cell cancer (ExPuSC) cell lines, and 691 resected NSCLC tumors and studied the relationship between PIK3CA alterations and mutational status of epidermal growth factor receptor (EGFR) signaling pathway genes (EGFR, KRAS, HER2, and BRAF). We also determined PIK3CA expression and activity and correlated the findings with effects on cell growth. We identified mutations in 4.7% of NSCLC cell lines and 1.6% of tumors of all major histologic types. Mutations in cell lines of small cell origin were limited to two ExPuSC cell lines. PIK3CA copy number gains were more frequent in squamous cell carcinoma (33.1%) than in adenocarcinoma (6.2%) or SCLC lines (4.7%). Mutational status of PIK3CA was not mutually exclusive to EGFR or KRAS. PIK3CA alterations were associated with increased phosphatidylinositol 3-kinase activity and phosphorylated Akt expression. RNA interference-mediated knockdown of PIK3CA inhibited colony formation of cell lines with PIK3CA mutations or gains but was not effective in PIK3CA wild-type cells. PIK3CA mutations or gains are present in a subset of lung cancers and are of functional importance.
Cell Surface Delivery of TRAIL Strongly Augments the Tumoricidal Activity of T Cells
Authors: Marco de Bruyn, Yunwei Wei, Valerie R. Wiersma, Douwe F. Samplonius, Harry G. Klip, Ate G.J. van der Zee, Baofeng Yang, Wijnand Helfrich, Edwin Bremer
Journal: Clinical Cancer Research (2011)

Abstract Purpose: Adoptive T-cell therapy generally fails to induce meaningful anticancer responses in patients with solid tumors. Here, we present a novel strategy designed to selectively enhance the tumoricidal activity of T cells by targeted delivery of TNF-related apoptosis-inducing ligand (TRAIL) to the T-cell surface. Experimental Design: We constructed two recombinant fusion proteins, anti-CD3:TRAIL and K12:TRAIL. Tumoricidal activity of T cells in the presence of these fusion proteins was assessed in solid tumor cell lines, primary patient-derived malignant cells, and in a murine xenograft model. Results: When added to T cells, K12:TRAIL and anti-CD3:TRAIL selectively bind to the T-cell surface antigens CD3 and CD7, respectively, leading to cell surface accretion of TRAIL. Subsequently, anti-CD3:TRAIL and K12:TRAIL increased the tumoricidal activity of T cells toward cancer cell lines and primary patient-derived malignant cells by more than 500-fold. Furthermore, T-cell surface delivery of TRAIL strongly inhibited tumor growth and increased survival time of xenografted mice more than 6-fold. Conclusions: Targeted delivery of TRAIL to cell surface antigens of T cells potently enhances the tumoricidal activity of T cells. This approach may be generally applicable to enhance the efficacy of adoptive T-cell therapy. Clin Cancer Res; 17(17); 5626–37. ©2011 AACR.
TCT-294 Symptomatic carotid plaques exhibit higher temperature. Insights from a new noninvasive method
Authors: Georgios Benetos, Konstantinos Toutouzas, Christina Deligianni, Maria Drakopoulou, Andreas Synetos, Konstantinos Stathogiannis, Haralampos Grassos, Kostas Spengos, Elias Siores, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2014)
Evolution of Tumor Invasiveness: The Adaptive Tumor Microenvironment Landscape Model
Authors: Hyung-Ok Lee, Ariosto S. Silva, Susanna Concilio, Yue-Sheng Li, Michael Slifker, Robert A. Gatenby, Jonathan D. Cheng
Journal: Cancer Research (2011)

Interactions between cancer cells and their microenvironment are crucial for promoting tumor growth and invasiveness. In the tumor adaptive landscape model, hypoxic and acidic microenvironmental conditions reduce the fitness of cancer cells and significantly restrict their proliferation. This selects for enhanced motility as cancer cells may evolve an invasive phenotype if the consequent cell movement is rewarded by proliferation. Here, we used an integrative approach combining a mathematical tumor adaptive landscape model with experimental studies to examine the evolutionary dynamics that promote an invasive cancer phenotype. Computer simulation results hypothesized an explicit coupling of motility and proliferation in cancer cells. The mathematical modeling results were also experimentally examined by selecting Panc-1 cells with enhanced motility on a fibroblast-derived 3-dimensional matrix for cells that move away from the unfavorable metabolic constraints. After multiple rounds of selection, the cells that adapted through increased motility were characterized for their phenotypic properties compared with stationary cells. Microarray and gene depletion studies showed the role of Rho-GDI2 in regulating both cell movement and proliferation. Together, this work illustrates the partnership between evolutionary mathematical modeling and experimental validation as a potentially useful approach to study the complex dynamics of the tumor microenvironment.
Starting an Adolescent and Young Adult Program: Some Success Stories and Some Obstacles to Overcome
Authors: Andrea Ferrari, David Thomas, Anna R.K. Franklin, Brandon M. Hayes-Lattin, Maurizio Mascarin, Winette van der Graaf, Karen H. Albritton
Journal: Journal of Clinical Oncology (2010)

Adolescent and young adult (AYA) patients seem to be in a sort of no-man's land, halfway between the two different worlds of pediatric and adult medical oncology and bearing the brunt, in terms of inclusion in clinical trials and quality of professional care, of the lack of integration between these two worlds. This article discusses the different organization models of care used in pediatric oncology (mainly family-focused) and in adult medical oncology (disease-focused). There is a growing awareness that these models are not ideally suited to the complex needs of AYA patients, which require a different, new, patient-focused multidisciplinary approach. A comprehensive, multipronged effort is required to bridge the gap in the care of AYA patients, with the ultimate challenge of creating a new discipline, AYA oncology. In this article, we review the experiences of AYA oncology programs in Europe, North America, and Australia, focusing on similarities and differences in strategy, as well as the major challenges and opportunities faced by these programs. Among the most important factors for the successful establishment of an AYA oncology service are the degree of engagement of both pediatric and adult medical oncologists, the philanthropic support of powerful charities, and the role of dedicated professionals across a range of disciplines in driving the development of services for AYA patients.
Fast Food Chains Move Toward Healthier Choices
Authors: John Burklow, Amy Aubertin
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Fast Food Chains Move Toward Healthier Choices Get access John Burklow, John Burklow Search for other works by this author on: Oxford Academic PubMed Google Scholar Amy Aubertin Amy Aubertin Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 5, 6 March 1991, Pages 325–326, https://doi.org/10.1093/jnci/83.5.325 Published: 06 March 1991