tbuckley/cabot-search huggingface dataset:
The impact of preoperative biological therapy on complications after abdominal surgery for inflammatory bowel disease
Authors: Takayuki Yamamoto, Manabu Shiraki
Journal: Gut (2012)

We read with interest the article by Waterman et al ,1 ‘Preoperative biological therapy and short-term outcomes of abdominal surgery in patients with inflammatory bowel disease (IBD)’. The authors had conducted a retrospective study evaluating the impact of preoperative biological therapy on complications after surgery for IBD. Preoperative treatment with tumour necrosis factor-α antagonists was not associated with postoperative infectious complications, anastomotic leaks and other perioperative complications. Based on these results, they do not recommend altering antitumour necrosis factor therapy, or the scheduling of surgery to prolong the time interval to operation.

We agree with the authors' recommendation. Surgery should not be delayed, and appropriate biological therapy should be continued perioperatively. However, surgeons would like to know whether they should avoid anastomosis, or create …
Family Noncommunication: The Search for Kidney Donors
Authors: ROBERTA G. SIMMONS, SUSAN D. KLEIN
Journal: American Journal of Psychiatry (1972)

Intensive study of the family communication patterns in the search for a kidney transplant donor revealed that, in a significant number of cases, communication is effectively blocked. The authors followed 83 transplant patients and their families throughout the pretransplant stage and for three weeks after the transplant. Although the noncommunication pattern appears to be maladaptive and rather stressful prior to the transplant, it seems to be beneficial for family cohesion in the period after a successful transplant.
Mammary Tumors, Mammary Gland Development, and Morphology of Ovaries in Virgin Mice of Strains C3H, CBA, and Their F&lt;sub&gt;1&lt;/sub&gt; Hybrids&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Flavia L. Richardson, Georgia Hall
Journal: JNCI Journal of the National Cancer Institute (1963)

A comparison of the rate of tumor development in virgin female mice of high-mammary-tumor strains C3H/HeJ and CBA/J and their F1 hybrids showed a significant difference between the average tumor age in the hybrid with the C3H mother and the hybrid with the CBA mother. The reciprocal hybrids had their tumors at mean ages closely approximating those of the maternal parent. This indicated that the agent in the milk of C3H females was more stimulating to early development of mammary tumors than that in the milk of CBA mice. The incidence of tumors was high in all groups. All mammary glands were similar in degree of lateral budding or acinar proliferation. Microscopic sections of the ovaries of all groups were alike in structure except that in old CBA females the ovaries usually showed infiltration of amyloid. Many corpora lutea and follicles were present and persisted for most of the lifetime of the animals. Thus there seems to be a correlation between the quantity of hormone-producing components of the ovaries, morphology of the mammary glands, and incidence of mammary tumors in virgin mice of high-mammary-tumor strains.
Verteporfin Photodynamic Therapy Cohort Study: Report 1: Effectiveness and Factors Influencing Outcomes
Authors: Simon P. Harding, Keith Tomlin, Barnaby C. Reeves, Julia Langham, Jemma Walker, James Carpenter, Richard Grieve, William P. Patton, Katherine A. Muldrew, Tunde Peto, Usha Chakravarthy
Journal: Ophthalmology (2009)
Hypercatabolism of normal IgG; an unexplained immunoglobulin abnormality in the connective tissue diseases
Authors: R. Dean Wochner
Journal: Journal of Clinical Investigation (1970)

The metabolism of radioiodinated IgG was studied in a series of 42 patients with connective tissue diseases (16 systemic lupus erythematosus, nine rheumatoid arthritis, five polymyositis, five vasculitis, and seven miscellaneous diagnoses). Fractional catabolic rates were increased and survival half-lives were shortened in all diagnostic categories indicating hypercatabolism of IgG. This hypercatabolism was masked by increased IgG synthesis, resulting in elevated serum concentrations of IgG in patients with systemic lupus erythematosus and rheumatoid arthritis and in generally normal concentrations in the others. The metabolism of iodinated IgM was also studied in eight patients with systemic lupus erythematosus, in seven with rheumatoid arthritis, and in 12 controls. The fractional catabolic rates were normal in both groups of patients. Serum concentrations of both IgM and IgA were moderately elevated in all diagnostic categories. Serum albumin metabolism was entirely normal in the nine subjects studied who were not receiving corticosteroids; in three who were receiving them, moderate hypercatabolism was observed. The hypercatabolism of IgG could not be accounted for by factors previously known to alter IgG metabolism. It was not observed in 15 patients with other chronic, inflammatory diseases and was not explained by concomitant administration of adrenal corticosteroids to some patients. Identical results were obtained whether the IgG was obtained from a patient himself or from a normal donor, demonstrating that the hypercatabolism is a host defect and not an abnormality of the protein. Thus, patients with connective tissue disease of several different diagnostic categories have been shown to have an unexplained immunoglobulin abnormality: they catabolize normal IgG at an accelerated rate.
Decrease in immunoglobulin free light chains in patients with rheumatoid arthritis upon rituximab (anti-CD20) treatment correlates with decrease in disease activity
Authors: T Groot Kormelink, J Tekstra, R M Thurlings, M H J Boumans, K Vos, P P Tak, J W J Bijlsma, F P J G Lafeber, F A Redegeld, J A G van Roon
Journal: Annals of the Rheumatic Diseases (2010)

Immunoglobulin (Ig) free light chains (FLCs) are short-lived B cell products that contribute to inflammation in several experimental disease models. In this study, FLC concentrations in inflamed joints of patients with rheumatoid arthritis (RA) as compared to patients with osteoarthritis were investigated. In addition, the relationship of FLCs and disease activity upon B cell depletion (rituximab) in patients with RA was studied.Synovial fluid (SF) and tissue from patients with RA were analysed for local presence of FLCs using ELISA and immunohistochemistry. In addition, FLC concentrations were measured (at baseline, 3 and 6 months after treatment) in 50 patients with RA with active disease who were treated with rituximab. Changes in FLCs were correlated to changes in disease activity and compared to alterations in IgM, IgG, IgA, IgM-rheumatoid factor (RF) and IgG-anti-citrullinated protein antibody (ACPA) concentrations.FLCs were detected in synovial tissue from patients with RA, and high FLC concentrations were found in SF from inflamed joints, which positively correlate with serum FLC concentrations. Serum FLC concentrations significantly correlated with disease activity score using 28 joint counts, erythrocyte sedimentation rate (ESR) and C reactive protein, and changes in FLC correlated with clinical improvement after rituximab treatment. Moreover, effect of treatment on FLC concentrations discriminated clinical responders from non-responders, whereas IgM-RF and IgG-ACPA significantly decreased in both patient groups.FLCs are abundantly present in inflamed joints and FLC levels correlate with disease activity. The correlation of FLC concentrations and disease activity indicates that FLCs may be relevant biomarkers for treatment response to rituximab in patients with RA and suggests that targeting FLC may be of importance in the therapy of RA.
Loss of the 14-3-3σ Tumor Suppressor Is a Critical Event in ErbB2-Mediated Tumor Progression
Authors: Chen Ling, Vi-Minh-Tri Su, Dongmei Zuo, William J. Muller
Journal: Cancer Discovery (2011)

Abstract 14-3-3σ is a putative tumor suppressor involved in cell-cycle progression and epithelial polarity. We demonstrate that loss of one or both copies of the conditional 14-3-3σ allele results in accelerated mammary and salivary tumorigenesis in mice expressing an activated erbB2 oncogene under the endogenous erbB2 promoter. Significantly, the majority of tumors bearing a single conditional 14-3-3σ allele lose expression of the remaining 14-3-3σ allele, which is associated with epigenetic methylation of the 14-3-3σ locus. In addition to accelerated tumor onset, in a mouse mammary tumor virus-driven ErbB2 tumor model, loss of 14-3-3σ results in enhanced metastatic phenotype that is correlated with loss of cellular junctions. Taken together, these results provide compelling evidence that 14-3-3σ is a potent tumor suppressor involved in ErbB2-driven breast cancer initiation and metastasis. Significance: 14-3-3σ has been identified as a normal mammary epithelial cell marker frequently downregulated during neoplastic development. Consistent with its potential role as a tumor suppressor, we demonstrate that targeted disruption of 14-3-3σ in a number of epithelial tissues can profoundly impact both the initiation and metastatic phases of ErbB2-mediated tumor progression through modulation of a number of distinct signaling networks. Cancer Discovery; 2(1); 68–81. ©2011 AACR. Read the Commentary on this article by Hynes and Smirnova, p. 19 This article is highlighted in the In This Issue feature, p. 1
Association of Early Repolarization Pattern on ECG with Risk of Cardiac and All-Cause Mortality: A Population-Based Prospective Cohort Study (MONICA/KORA)
Authors: Moritz F. Sinner, Wibke Reinhard, Martina Müller, Britt-Maria Beckmann, Eimo Martens, Siegfried Perz, Arne Pfeufer, Janina Winogradow, Klaus Stark, Christa Meisinger, H.-Erich Wichmann, Annette Peters, Günter A. J. Riegger, Gerhard Steinbeck, Christian Hengstenberg, Stefan Kääb
Journal: PLoS Medicine (2010)

Background Early repolarization pattern (ERP) on electrocardiogram was associated with idiopathic ventricular fibrillation and sudden cardiac arrest in a case-control study and with cardiovascular mortality in a Finnish community-based sample. We sought to determine ERP prevalence and its association with cardiac and all-cause mortality in a large, prospective, population-based case-cohort study (Monitoring of Cardiovascular Diseases and Conditions [MONICA]/KORA [Cooperative Health Research in the Region of Augsburg]) comprised of individuals of Central-European descent. Methods and Findings Electrocardiograms of 1,945 participants aged 35–74 y, representing a source population of 6,213 individuals, were analyzed applying a case-cohort design. Mean follow-up was 18.9 y. Cause of death was ascertained by the 9th revision of the International Classification of Disease (ICD-9) codes as documented in death certificates. ERP-attributable effects on mortality were determined by a weighted Cox proportional hazard model adjusted for covariables. Prevalence of ERP was 13.1% in our study. ERP was associated with cardiac and all-cause mortality, most pronounced in those of younger age and male sex; a clear ERP-age interaction was detected (p = 0.005). Age-stratified analyses showed hazard ratios (HRs) for cardiac mortality of 1.96 (95% confidence interval [CI] 1.05–3.68, p = 0.035) for both sexes and 2.65 (95% CI 1.21–5.83, p = 0.015) for men between 35–54 y. An inferior localization of ERP further increased ERP-attributable cardiac mortality to HRs of 3.15 (95% CI 1.58–6.28, p = 0.001) for both sexes and to 4.27 (95% CI 1.90–9.61, p<0.001) for men between 35–54 y. HRs for all-cause mortality were weaker but reached significance. Conclusions We found a high prevalence of ERP in our population-based cohort of middle-aged individuals. ERP was associated with about a 2- to 4-fold increased risk of cardiac mortality in individuals between 35 and 54 y. An inferior localization of ERP was associated with a particularly increased risk. Please see later in the article for the Editors' Summary
Cutting edge genetic studies in primary ciliary dyskinesia
Authors: Michael R Knowles, Margaret W Leigh, Maimoona A Zariwala
Journal: Thorax (2012)

as 'cutting edge', rather than 'beyond the fringe'. 2 Indeed, we predict that in 5 years genetic testing will be more readily available and used worldwide for diagnostic studies in primary ciliary dyskinesia than high speed ciliary waveform analysis.Would Drs Bush and Hogg like to make a wager?
Response to Comment on: Ellervik et al. Elevated Transferrin Saturation and Risk of Diabetes: Three Population-Based Studies. Diabetes Care 2011;34:2256-2258
Authors: Christina Ellervik, Thomas Mandrup-Poulsen, Henrik Birgens, Børge G. Nordestgaard
Journal: Diabetes Care (2012)

We thank Conway for her comment (1) on our article in Diabetes Care (2) on the risk of diabetes associated with elevated transferrin saturation levels in two follow-up studies (risk as hazard ratios and exposure preceding disease) and a case-control study (risk as odds ratio) with neither study being cross-sectional.

We agree with Conway that the pathophysiology of diabetes is complex. We acknowledge that elevated cellular iron concentrations in insulin-sensitive tissue and the pancreatic …
A Naturalistic Study of Consecutive Agitated Emergency Department Patients Treated With Intramuscular Olanzapine Prior to Consent
Authors: CRISTIAN DAMSA, ERIC ADAM, CORALIE LAZIGNAC, ADRIANA MIHAI, FRANCOIS DE GREGORIO, JOSEPH LEJEUNE, SUSANNE MARIS, EMMANUEL CLIVAZ, MICHAEL H. ALLEN
Journal: American Journal of Psychiatry (2008)
Graded global ischaemia and reperfusion of the isolated perfused rat heart: characterisation by 31P NMR spectroscopy of the extent of energy metabolism damage
Authors: N LAVANCHY, J MARTIN, A ROSSI
Journal: Cardiovascular Research (1984)

Journal Article Graded global ischaemia and reperfusion of the isolated perfused rat heart: characterisation by 31P NMR spectroscopy of the extent of energy metabolism damage Get access N LAVANCHY, N LAVANCHY Search for other works by this author on: Oxford Academic PubMed Google Scholar J MARTIN, J MARTIN **Centre d'Etudes Nucléaires de Grenoble 85 X, 38041 Grenoble Cédex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar A ROSSI A ROSSI Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 9, September 1984, Pages 573–582, https://doi.org/10.1093/cvr/18.9.573 Published: 01 September 1984
Cell-Mediated Responses in Dogs With Spontaneous Neoplasms. I. Detection of Cell-Mediated Cytotoxicity by the Chromium-51 Release Assay&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: G R Betton, N T Gorman
Journal: JNCI Journal of the National Cancer Institute (1978)

A series of 43 dogs with spontaneous melanomas, sarcomas, or mammary carcinomas were tested for peripheral blood lymphocytotoxicity against a range of allogeneic tumor cells in vitro on one or more occasions during therapy. All tumor-bearer groups contained a proportion of dogs showing a significant 51Cr release with increasing effector-to-target cell ratios. However, cytotoxicity was not restricted for target cells of the same histologic type as that of the effector cell donor. Some unrelated target cells more sensitive to nonspecific effects showed a greater cytotoxicity in some instances. Control effector cells from healthy dogs were nonspecifically cytotoxic for a range of tumor target cells in a similar proportion of instances. Short-term cultures of autochthonous tumor target cells were resistant to lysis in the 51Cr release assay. The findings did not provide evidence for the existence of specific tumor antigens operative to allogeneic 51Cr release cytotoxicity assays.
Inhibition of DNA Repair by a Herpes Simplex Virus Vector Enhances the Radiosensitivity of Human Glioblastoma Cells
Authors: Costas G. Hadjipanayis, Neal A. DeLuca
Journal: Cancer Research (2005)

Abstract Expression of the herpes simplex virus (HSV) protein, ICP0, from the viral genome, rendered two radioresistant human glioblastoma multiforme cell lines more sensitive to the effects of ionizing radiation. Using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and clonogenic survival assays, U87-MG and T98 cell survival was more greatly decreased as a function of ionizing radiation dose when ICP0 was preexpressed in cells compared with when ICP0 was not expressed. Consistent with previous results, we found that the catalytic subunit of DNA-dependent protein kinase was degraded as a function of ICP0 in both cell types. This most likely resulted in the inhibition of DNA repair as inferred by the persistence of γH2AX foci or DNA double-strand breaks. Enhanced apoptosis was also found to occur following irradiation of U87-MG cells preinfected with the ICP0-producing HSV-1 mutant, d106. Our results suggest that expression of ICP0 in human glioblastoma multiforme cells inhibits the repair of DNA double-strand breaks after ionizing radiation treatment, decreasing the survival of these cells in part by induction of apoptosis.
HLA B5 and Behcet's disease.
Authors: H Yazici, M A Chamberlain, G M Schreuder, J Bird-Stewart, M Denman
Journal: Annals of the Rheumatic Diseases (1983)

HLA B5 and Behget's disease SIR, May we draw your attention again to the inheritance of the HLA B5 antigen and its association with Behcet's disease?The association of the HLA B5 and especially its Bw5l split' 2 with Behcet's disease was established in Japan'`3 and Turkey.4'5There is also a weak association C = complete Behqet's disease.I = incomplete.S = suspect.P = possible.
Dengue outlook for the World Cup in Brazil: an early warning model framework driven by real-time seasonal climate forecasts
Authors: Rachel Lowe, Christovam Barcellos, Caio A S Coelho, Trevor C Bailey, Giovanini Evelim Coelho, Richard Graham, Tim Jupp, Walter Massa Ramalho, Marilia Sá Carvalho, David B Stephenson, Xavier Rodó
Journal: The Lancet Infectious Diseases (2014)
Needs assessment, priority setting, and contracts for health care: an economic view.
Authors: C Donaldson, G Mooney
Journal: BMJ (1991)

migrant labor in South Africa. IntjHealthServ 1991;21:157-73. 7 Hunt CW. Migrant labor and sexually transmitted disease: AIDS in Africa. J Health Soc Behav 1989;30:353-73. 8 Baldo M, Cabral AJ R. Low intensity wars and social determinations of the HIV transmissions: the search for a new paradigm to guide research and control of the HIV-AIDS pandemic. In: Stein Z, Zwi A, eds. Action on AIDS tn southern Africa. Maputo conjerence on health in transition in southern Africa, April 1990. New York: Committee for Health in Southern Africa, 1991; 34-43. 9 Piot P, Holmes KK. Sexually transmitted disease. In: Warren KS, Mahmoud AAF, eds. Tropical and geographical medicine. 2nd ed. New York: McGraw Hill, 1988:894-910. 10 Rosenfield PL. Social determinants of tropical disease. In: Warren KS, Mahmoud AAF, eds. Tropical and geographical medicine. 2nd ed. New York: McGraw Hill, 1988:197-205. 11 Freudenberg N. Health education for social change: a strategy for public health in the US. InternationalJournal ofHealth Education 1981;24:1-8. 12 Bassett MT, Mhloyi M. Women and AIDS in Zimbabwe: the making of an epidemic. Intl Health Serv 1991;21:143-56. 13 Freudenberg N, Lee J, Silver D. How black and Latino community organizations respond to the AIDS epidemic: a case study in one New York City neighbourhood. AIDS Education and Prevention 1989;1: 12-21. 14 Green LW, Raeburn JM. Health promotion. What is it? What will it become? Health Promnotion 1988;3:151-9. 15 Ottawa charter for health promotion. Health Promotion 1986;1:3-5. 16 Freudenberg N. AIDS prevention in the United States: lessons from the first decade. IntJ Health Serv 1990;20:589-99. 17 Packard RM, Epstein P. Epidemiologists, social scientists, and the structure of medical research on AIDS in Africa. Soc Sci Med 1991;33: 771-94. 18 Sanders D, Abdulrahman S. AIDS in Africa: the implications of economic recession and structural adjustment. Health Policy and Planning 1991;6: 157-65. 19 Nabarro D, McConnell C. The impact of AIDS on socioeconomic development. AIDS 1989;3 (suppl 1):S265-72.
Cystic fibrosis. 6. Gastrointestinal and nutritional aspects.
Authors: H Kopelman
Journal: Thorax (1991)

<h3>Objective</h3> To evaluate a new tool to aid interpretation of copy number variants (CNVs) in individuals with neurodevelopmental disabilities. <h3>Methods</h3> Critical exon indexing (CEI) was used to identify genes with critical exons (CEGs) from clinically reported CNVs, which may contribute to neurodevelopmental disorders (NDDs). The 742 pathogenic CNVs and 1,363 variants of unknown significance (VUS) identified by chromosomal microarray analysis in 5,487 individuals with NDDs were subjected to CEI to identify CEGs. CEGs identified in a subsequent random series of VUS were evaluated for relevance to CNV interpretation. <h3>Results</h3> CEI identified a total of 2,492 unique CEGs in pathogenic CNVs and 953 in VUS compared with 259 CEGs in 6,965 CNVs from 873 controls. These differences are highly significant (<i>p</i> &lt; 0.00001) whether compared as frequency, average, or normalized by CNV size. Twenty-one percent of VUS CEGs were not represented in Online Mendelian Inheritance in Man, highlighting limitations of existing resources for identifying potentially impactful genes within CNVs. CEGs were highly correlated with other indices and known pathways of relevance. Separately, 136 random VUS reports were reevaluated, and 76% of CEGs had not been commented on. In multiple cases, further investigation yielded additional relevant literature aiding interpretation. As one specific example, we discuss <i>GTF2I</i> as a CEG, which likely alters interpretation of several reported duplication VUS in the Williams-Beuren region. <h3>Conclusions</h3> Application of CEI to CNVs in individuals with NDDs can identify genes of potential clinical relevance, aid laboratories in effectively searching the clinical literature, and support the clinical reporting of poorly annotated VUS.
Implementing American Heart Association Pediatric and Adult Nutrition Guidelines
Authors: Samuel S. Gidding, Alice H. Lichtenstein, Myles S. Faith, Allison Karpyn, Julie A. Mennella, Barry Popkin, Jonelle Rowe, Linda Van Horn, Laurie Whitsel
Journal: Circulation (2009)

The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel.Specifically, all members of the writing group are required to complete and
Sequencing errors and molecular evolutionary analysis.
Authors: A G Clark, T S Whittam
Journal: Molecular Biology and Evolution (1992)

Heuristic approaches were used to quantify the influence that sequencing errors have on estimates of nucleotide diversity, substitution rate, and the construction of genealogies. Error rates of less than 1 nucleotide/kb probably have little affect on conclusions about the evolutionary history of highly polymorphic organisms such as Drosophila and Escherichia coli, but organisms with very low nucleotide diversity, such as humans, require greater sequencing accuracy. A scan of GenBank for corrections of previous errors reveals that sequencing errors are highly nonrandom.