tbuckley/cabot-search huggingface dataset:
Late-breaking abstract: Evaluation of CRP, PCT, clinical pulmonary infection score and pneumonia severity scores for the diagnosis and prognosis of nursing home acquired pneumonia
Authors: Ilias Porfyridis, Georgios Georgiadis, Paris Vogiazianos, Andreas Georgiou
Journal: European Respiratory Journal (2011)

Introduction:  Nursing home acquired pneumonia (NHAP) represents a distinct group of respiratory infections with different risk factors, clinical presentation and higher mortality than CAP.   Aim:  To evaluate the diagnostic value of clinical pulmonary infection score (CPIS), CRP and PCT and compare the accuracy of CURB-65, pneumonia severity index (PSI), nursing home acquired pneumonia (NHAP) index, SMART-COP and SOAR in predicting in-hospital mortality of NHAP.   Methods:  49 residents in nursing homes admitted to pulmonary department were enrolled in the study. Pneumonia severity scores were recorded. CRP and PCT were measured by immunonephelometry and immunochromatografy respectively.   Results:  39 patients were diagnosed with NHAP (group A) and 10 with other pulmonary disorders (group B). Mean ± SE CRP was 16.53±1.65mg/dl in group A and 5.26±2.56mg/dl (p=0.002) in group B. Mean ± SE PCT was 1.78±0.39ng/ml in group A and 0.5±0.09ng/ml (p=0.001) in group B and mean± SE CPIC was 5.7±0.18 in group A and 2±0.53 (p   Conclusion:  The CPIS, PCT and CRP are reliable for the diagnosis of NHAP. PCT, CRP and CURB65 were accurate for predicting in-hospital mortality in patients with NHAP.
Erratum: “Exposure to Household Air Pollution from Wood Combustion and Association with Respiratory Symptoms and Lung Function in Nonsmoking Women: Results from the RESPIRE Trial, Guatemala”
Authors: Daniel Pope, Esperanza Diaz, Tone Smith-Sivertsen, Rolv T. Lie, Per Bakke, John R. Balmes, Kirk R. Smith, Nigel G. Bruce
Journal: Environmental Health Perspectives (2016)
Culture of Malignant Tumors of the Syrian Hamster
Authors: G. E. Moore, D. Mount, G. Tara, N. Schwartz
Journal: JNCI Journal of the National Cancer Institute (1963)

Ten tumors of the golden hamster (Mesocricetus auratus) were cultured in vitro. Five tumor-cell lines were grown in suspension cultures. A line of melanotic melanoma cells retained its pigment-producing ability for a prolonged period. The individuality of these cell lines was evident from their growth characteristics in vitro and in vivo and from analysis of their chromosome constitutions.
Comparative Effectiveness of Minimally Invasive Hysterectomy for Endometrial Cancer
Authors: Jason D. Wright, William M. Burke, Ana I. Tergas, June Y. Hou, Yongmei Huang, Jim C. Hu, Grace Clarke Hillyer, Cande V. Ananth, Alfred I. Neugut, Dawn L. Hershman
Journal: Journal of Clinical Oncology (2016)

Despite the potential benefits of minimally invasive hysterectomy for uterine cancer, population-level data describing the procedure's safety in unselected patients are lacking. We examined the use of minimally invasive surgery and the association between the route of the procedure and long-term survival.We used the SEER-Medicare database to identify women with stage I-III uterine cancer who underwent hysterectomy from 2006 to 2011. Patients who underwent abdominal hysterectomy were compared with those who had minimally invasive hysterectomy (laparoscopic and robot-assisted). Perioperative morbidity, use of adjuvant therapy, and long-term survival were examined after propensity score balancing.We identified 6,304 patients, including 4,139 (65.7%) who underwent abdominal hysterectomy and 2,165 (34.3%) who underwent minimally invasive hysterectomy; performance of minimally invasive hysterectomy increased from 9.3% in 2006 to 61.7% in 2011. Robot-assisted procedures accounted for 62.3% of the minimally invasive operations. Compared with women who underwent abdominal hysterectomy, minimally invasive hysterectomy was associated with a lower overall complication rate (22.7% v 39.7%; P < .001), and lower perioperative mortality (0.6% v 1.1%), but these women were more likely to receive adjuvant pelvic radiotherapy (34.3% v 31.3%) and brachytherapy (33.6% v 31.0%; P < .05). The complication rate was higher after robot-assisted hysterectomy compared with laparoscopic hysterectomy (23.7% v 19.5%; P = .03). There was no association between the use of minimally invasive hysterectomy and either overall (HR, 0.89; 95% CI, 0.75 to 1.04) or cancer-specific (HR, 0.83; 95% CI, 0.59 to 1.16) mortality.Minimally invasive hysterectomy does not appear to compromise long-term survival for women with endometrial cancer.
Treatment of postmenopausal women with osteoporosis for six years with denosumab : three-year results from the freedom extension
Authors: R Chapurlat, S Papapoulos, JP Brown, N Franchimont, ML Brandi, E Czerwinski, MA Krieg, Z Man, D Mellstrom, SC Radominski, Jean-Yves Reginster, H Resch, JA Roman, C Roux, NS Daizadeh, ML Geller, S Smith, RB Wagman, Cummings, HG Bone
Journal: Annals of the Rheumatic Diseases (2012)
Abstract 2423: Abdominal Aortic Wall-Thickness by Magnetic Resonance Imaging and Cardiovascular Disease in a Multi-ethnic Population-Based Study
Authors: Carlos Timaran, Eric Rosero, Patrick Clagett, Hao Lo, Ron Peshock
Journal: Circulation (2006)

Objective: Autopsy studies have revealed association between the prevalence of cardiovascular disease and atherosclerosis in the abdominal aorta. Magnetic resonance imaging (MRI) has been reported ...
A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas
Authors: John A. Baron, Elizabeth L. Barry, Leila A. Mott, Judy R. Rees, Robert S. Sandler, Dale C. Snover, Roberd M. Bostick, Anastasia Ivanova, Bernard F. Cole, Dennis J. Ahnen, Gerald J. Beck, Robert S. Bresalier, Carol A. Burke, Timothy R. Church, Marcia Cruz-Correa, Jane C. Figueiredo, Michael Goodman, Adam S. Kim, Douglas J. Robertson, Richard Rothstein, Aasma Shaukat, March E. Seabrook, Robert W. Summers
Journal: New England Journal of Medicine (2015)

Epidemiologic and preclinical data suggest that higher intake and serum levels of vitamin D and higher intake of calcium reduce the risk of colorectal neoplasia. To further study the chemopreventive potential of these nutrients, we conducted a randomized, double-blind, placebo-controlled trial of supplementation with vitamin D, calcium, or both for the prevention of colorectal adenomas.
Food allergies can persist after myeloablative hematopoietic stem cell transplantation in dedicator of cytokinesis 8–deficient patients
Authors: Corinne S. Happel, Kelly D. Stone, Alexandra F. Freeman, Nirali N. Shah, Angela Wang, Jonathan J. Lyons, Pamela A. Guerrerio, Dennis D. Hickstein, Helen C. Su
Journal: Journal of Allergy and Clinical Immunology (2016)
Coronary Stenting and a-Adrenergic Blockade Counteract Left Ventricular Dysfunction in Acute Myocardial Infarction Patients
Authors: I. Marco, Carlo Palombo, M. Kozàkovà, G. Anguissola, M. Bernies, B. Cassagneau, J. Fajadet, J. Marco, L. Gregorini
Journal: Journal of the American College of Cardiology (1998)
Concurrent chemoradiation for locally advanced squamous vulva carcinoma
Authors: P. Kamnerdsupaphon, V. Sukthomya, I. Chitapanarux, A. Tonusin, V. Lorvidhaya
Journal: Journal of Clinical Oncology (2005)

5169 Background: The purpose of this study is to evaluate a regimen of chemoradiotherapy for those patients with locally advanced squamous cell carcinoma of the vulva. Methods: From July 2000 to February 2004, eleven patients with the diagnosis of locally advanced squamous cell carcinoma of the vulva were treated with simultaneous chemoradiation The median age was 48 years old (32 to 66). Ninety-one percent (10 out of 11) of the histopathology revealed well-differentiated cell-type. Nine patients (81.9%) were stage IV disease and the other 2 patients (18.2%) were stage III. The radiotherapy is the locoregional treatment including the vulva, pelvic and bilateral groin regions. The pelvic radiation prescribed dose ranged from 45 to 60 Gy and the vulva and groin regions ranged from 45 to 70 Gy, given with the conventional fractionation (180 to 200 cGy per daily fraction, 5 times a week). The chemotherapy regimen was the combination of mitomycin 12 mg/m2 on day 1 plus 5-fluorouracil 1,000 mg/m2/day on days 1 through 4, every 28 days for 2 cycles. Results: The overall responsiveness was 100% with 7 (63.7%) complete response and 4 (36.4%) partial response. At the median follow up of 12 months (6 to 24 months), there was only one patient (9.1%) developed local recurrent disease at 5 months. There were 3 patients (27.3%) experienced grade III skin reaction and 2 patients (18.2%) had grade III anemia and 2 patients (27.3%) had grade III granulocytopenia. No patients died from the treatment. Conclusions: Concurrent chemoradiation is highly effective and well tolerated for this disease and may hold curative potential for some patients with surgically unresectable or medical inoperable situations. No significant financial relationships to disclose.
Enhanced Oncornavirus Expression in Marek's Disease Tumors From Specific-Pathogen-Free Chickens&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: W F Campbell, J W Frankel
Journal: JNCI Journal of the National Cancer Institute (1979)

An oncornavirus was recovered from cell cultures of kidney tumors from specific-pathogen-free chickens inoculated with Marek's disease herpesvirus (MDHV). The MDHV inoculum was free of infectious avian leukosis virus (ALV). Direct examination of a variety of tissues from MDHV-inoculated chickens demonstrated increased levels of ALV-specific RNA compared to tissues from diluent-inoculated (control) chickens. DNA from cultured kidney tumor cells annealed to an ALV complementary DNA probe at the same rate and exhibited the same extent of homology as DNA from cultured control kidney cells. This finding indicated the absence of exogenous ALV proviral sequences. As with vertically transmitted endogenous ALV of subgroup E, the oncornavirus recovered from kidney tumor cell cultures failed to replicate in chicken embryo fibroblast (CEF) cultures of the C/E phenotype, but did replicate in turkey embryo fibroblasts (TEF), which are permissive for replication of endogenous ALV of subgroup E. These oncornavirus particles served as a helper virus to form Rous sarcoma virus pseudotypes, which produced foci in TEF cultures but not in CEF cultures of the C/E phenotype. Whether enhanced expression of endogenous oncornavirus contributes to MDHV-induced tumorigenesis is not known.
Neoadjuvant sequential treatment in women with breast cancer: FEC100 then docetaxel: Results in clinical practice
Authors: C. Couteau, F. Dalenc, G. Ferron, M. Lacroix-Triki, M.-H. Marty, I. Garrido, L. Gladieff, H. Roché
Journal: Journal of Clinical Oncology (2004)

749 Background: Since 2002, all women with breast carcinoma (BC) without possibility of conservative treatment or with clinical doubling time (CDB) <6 months, received neoadjuvant chemotherapy. Methods: selection : grade 2/3, non inflammatory, non metastatic, biopsy proven BC. Sequential schedule was FEC 100 (epirubicine 100mg/m2, 5FU 500mg/m2, cyclophosphamide 500 mg/m2) x 4 cycles (cy) then docetaxel (TxT)100 mg/m2 x4cy, q3 wks. Thereafter, all pts had surgery then radiotherapy and hormotherapy by tamoxifene when it was appropriate. Results: 40 pts entered this study of whom 29 underwent surgery, the others were ongoing. Characteristics of pts : median age 43.5years [30–58], tumor stage T2 12pts (30%), T3 25pts (62.5%), T4 3pts (7.5%), N0 15pts, N1 22pts. 30 pts (75%) had tumor CDB <6months. Hormonal receptors were negative for almost pts. Histological subtypes : ductal 34pts (85%), lobular 4pts, comedocarcinoma 2 pts, with grade 3 26pts(65%), grade 2 14pts (35%). On 29pts analysed, 22 received all the sequence (8cy), 5 had 3 FEC 100 then 3TxT respectively. FEC 111cy administered, Txt 108cy. Dose was reduced in pts (9cy). Only 3pts received GCSF without dose reduction. One pt discontinued due to toxicity after 3 cy of TXT. One pt had progressive disease under treatment. Clinical response after FEC: CR 9pts (31%), PR11(38%), SD 9pts(31%), after TXT CR 18(62%), PR 9(31%), SD2(7%). 19 pts had conservative surgery (65.5%), 10 underwent mastectomy (3 due to initial retroaerolar tumor).Pathological response were pCR( breast and nodes) 10pts (34.5%), Chevallier classification 11pts(10 grade1, 1 grade 2)(38%), sotaloff classification TANA 4pts, TANB 7pts. 13 pts had residual pathological lymph nodes. Conclusions: Our sequential treatment adapted to Aberdeen shedule shown similar results in pathological CR. These results obtained in unselected pts confirmed those obtained in large clinical studies. According to published results, administration of 4cy seems unefficient with increased of CR after 8cy. Neoadjuvant sequential treatment is effective with antracyclines and docetaxel in non metastatic breast carcinoma in clinical practice No significant financial relationships to disclose.
Prefrontal GABA Levels Measured With Magnetic Resonance Spectroscopy in Patients With Psychosis and Unaffected Siblings
Authors: Stefano Marenco, Christian Meyer, Susan Kuo, Jan Willem van der Veen, Jun Shen, Katherine DeJong, Alan S. Barnett, Jose A. Apud, Dwight Dickinson, Daniel R. Weinberger, Karen F. Berman
Journal: American Journal of Psychiatry (2016)

The authors sought to compare GABA levels in treated and untreated patients with psychosis with levels in their unaffected siblings and healthy control subjects, and to assess the effects of antipsychotic medications on GABA levels. GABA+ levels (i.e., including signal from unrelated proteins or macromolecules) referenced to creatine or water were studied with J-edited proton spectroscopy in the dorsal anterior cingulate cortex of 289 individuals: 184 healthy control subjects, 83 treated patients with psychosis, 25 untreated patients, 31 unaffected siblings, and 17 patients studied both while off all medications and while on a single antipsychotic. GABA+ levels in the dorsal anterior cingulate did not differ between untreated patients and healthy controls. For treated patients, levels were modestly lower for GABA+/creatine but did not differ for GABA+/water compared with healthy controls. For both GABA+ measures, unaffected siblings had significantly lower levels compared with controls. GABA+/creatine showed a modest degree of familiality (intraclass correlation=0.36). Antipsychotic dosage was negatively correlated with GABA+ levels, but the on-off medication studies indicated no difference in GABA+ levels on antipsychotics compared with off antipsychotics. GABA+/creatine in the dorsal anterior cingulate may constitute an intermediate phenotype with low effect size for psychosis, but GABA+/water measures do not fully support this conclusion. Low GABA+ levels in unaffected siblings could suggest a genetic association, but the failure to find consistent evidence of this phenotype in the patients themselves weakens genetic inference on risk for psychosis. Replication in independent samples of siblings is warranted to confirm the potential genetic risk association.
Use of progesterone receptor (PR) expression to predict benefit from prolonged adjuvant tamoxifen (TAM) in breast cancer: Results of a biomarker study from the TAM01 randomized Trial
Authors: M. Mathieu, J. De la Cruz, A. S. Veilllard, S. Koscielny, C. Bourgier, F. Rimareix, M. Spielmann, T. Delozier, F. Andre, S. Delaloge
Journal: Journal of Clinical Oncology (2009)

536 Background: The optimal duration of endocrine therapy ranges between 5 and 7 years. Recent data suggest that a subset of patients could benefit from extended adjuvant TAM. The goal of this biomarker study was to identify potential candidates for extended TAM. Methods: After 2–3 yrs of adjuvant TAM, 3793 patients (pts) were randomized to continue TAM up to 10 yrs, or to stop treatment (Delozier, J Clin Oncol. 2000). The tumor blocks of 587/988 pts included at the Institut Gustave-Roussy, were used to construct a tissue micro-array (TMA). Immunohistochemical stainings were performed for ER, PR, bcl2, p53 (+: &gt; 10% of stained cells), HER-2 (+: score 3+), EGFR1 (+: any positivity), PAK1, IGFR1 (+: intensity = 2 or 3). Median follow-up was 12 years. The prognostic values of biomarkers were assessed by a Cox model adjusted for clinical prognostic parameters and predictive values by interaction tests. Only statistical tests with P&lt;0.01 were considered significant because of multi-hypothesis testing. Time-to-relapse (TTR), excluding contralateral cancer, was the main study endpoint. Results: Median age of the cohort included in the TMA was 63. Tumor characteristics : 54% node-positive, 85% ER+, 64% PR+, 7% HER-2+, 68% bcl2+, 14% p53+, 8% EGFR1+, 46% PAK1, 45% IGFR1. None of the biomarkers were prognostically significant. However, PR expression was strongly predictive for the efficacy of extended TAM on TTR (interaction test, p = 0.003). Long-term TAM was associated with a hazard ratio of 0.56, (95% CI: 0.30–1.03) and 1.94 (95%CI = 0.80–4.70) for PR+ and PR- pts respectively. A trend towards interaction between ER (p = 0.04), HER-2 (p = 0.05) and Bcl2 (p = 0.03) expression and a benefit from TAM was also observed, with a trend towards greater efficacy of prolonged TAM in ER+/HER-2-/ bcl2+ tumors. P53, EGFR1, PAK1, IGFR1 expression had no predictive value. Conclusions: PR expression, probably reflective of ER activation and functionality, strongly predicts benefit from continuation of TAM after 2–3 yrs. These data could provide a rationale for evaluating the efficacy of TAM after 5 years of anti-aromatase therapy in post-menopausal women with ER+/PR+/bcl2+/Her2-tumors. No significant financial relationships to disclose.
Abstract 16544: Focal Fibrosis Predicts Monomorphic VT but Not Polymorphic VT or VF in Nonischemic Dilated Cardiomyopathy
Authors: Sebastiaan R Piers, Kimberly Everaerts, Rob Van der Geest, Mark R Hazebroek, Jeroen Venlet, Hans-Marc Siebelink, Laurent Pison, Martin J Schalij, Sebastiaan C Bekkers, Stephane Heymans, Katja Zeppenfeld
Journal: Circulation (2014)

Purpose: This study aimed to analyze the effect of focal myocardial fibrosis, assessed by late gadolinium enhancement MRI (LGE-MRI), on the occurrence and type of ventricular arrhythmia in patients with nonischemic dilated cardiomyopathy (NIDCM). Methods: We included consecutive patients with NIDCM who underwent LGE-MRI before implantable cardioverter-defibrillator (ICD) implantation at two centers. LGE was defined by signal intensity ≥35% of maximal signal intensity and subdivided into core and border zone (≥50% and 35-50% of maximal signal intensity, respectively), and according to (non)basal location and transmurality. ICD recordings and 12-lead ECGs were reviewed to determine the occurrence and type of ventricular arrhythmia during follow-up. Results: Of all 87 patients (62% male, age 56±13 years, LVEF 29±12%), 55 patients (63%) had LGE (median 6.3g, IQR 0.0-13.8g). During a median follow-up of 45 months (interquartile range, 23-67), monomorphic VT occurred in 18 (21%) patients, and polymorphic VT/VF in 10 (11%). LGE predicted monomorphic VT (Log-rank, p&lt;0.001), but not polymorphic VT/VF (Log-rank, p=0.40). The optimal cut-off value for LGE to predict monomorphic VT was 7.2 grams (area under curve 0.84). Features associated with high risk for monomorphic VT were core extent, location in basal segments and area with 51-75% transmurality. Conclusion: Focal fibrosis assessed by LGE-MRI predicts monomorphic VT, but not polymorphic VT/VF. The risk for monomorphic VT was particularly high when the LGE extent was ≥7.2 grams. The differences in underlying substrate and associated types of arrhythmia may have important implications for risk stratification and therapeutic interventions in patients with NIDCM.
PTU-237 Band on the run: no follow up appointments required after rubber band ligation of haemorrhoids?
Authors: J Blackwell, A Bhalla, J Mitchell, J Williams, J Lund
Journal: Gut (2015)

<h3>Introduction</h3> Several surgical options exist for the treatment of haemorrhoids, with rubber band ligation (RBL) being the commonest. Long term outcome data for RBL is sparse. We investigate the effectiveness of RBL haemorrhoids in the outpatient setting. <h3>Method</h3> Data for consecutive patients undergoing RBL of haemorrhoids between January 2013–January 2014 was collected retrospectively. Patients were followed up for a minimum of one year with specific data collected for previous treatments, proctoscopic appearances, and outcomes after RBL. <h3>Results</h3> Two hundred and sixty four patients [145 males, median age 52 years (range 19–94)] underwent RBL. In 177 this episode of RBL was their first intervention for haemorrhoids, with the remaining patients having previously had several different treatments including RBL (31%, n = 81), surgery (3%, n = 7) and sclerotherapy (&lt;1%, n = 1). Median time between previous treatments and RBL was 1 year (range 1 month- 30 years). The number of haemorrhoids was noted in 65% of patients (n = 177; solitary haemorrhoid 23% n = 40, multiple haemorrhoids 77% n = 137). Grade was recorded in 94/264: 1% Grade I (n = 11), 26% Grade II (n = 46), 19% Grade III (n = 33), 2% Grade IV (n = 4). Post RBL 88% (n = 231) of patients were offered 10 week open outpatient appointment as per local protocol, 11 patients (4%) were discharged and 22 (8%) were given specific dates for follow up (median 10 months (range 4–20 months)). 17% required further investigation: endoscopy in 16% (n = 44, where 37/44 were patients over the age of 50 years which follows local protocol for rectal bleed), defecating proctography in 2 patients and CT pneumocolon in 2 patients. At 1-year post RBL 72% (n = 192) of patients had not returned, but the remaining 72 were re-referred (mean time 8 months, standard deviation 154 days) with recurrent symptoms. Further treatment was with repeat RBL (n = 30) and surgery (n = 33), 1 patient referred to dermatology, one patient was referred to gastroenterology with proctitis. Seven patients returning to clinic either declined further banding or data was unavailable. <h3>Conclusion</h3> Patients presenting with haemorrhoids can be treated with RBL and then discharged (notwithstanding local protocols for exclusion of malignancy in patients over a certain age with PR bleeding). Three quarters will not return with further symptoms and the remainder will not represent for a year, so making planned follow up unnecessary. <h3>Disclosure of interest</h3> None Declared.