tbuckley/cabot-search huggingface dataset:
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors
Authors: Elien M. Doorduijn, Marjolein Sluijter, Bianca J. Querido, Cláudia C. Oliveira, Adnane Achour, Ferry Ossendorp, Sjoerd H. van der Burg, Thorbald van Hall
Journal: Journal of Clinical Investigation (2016)

Tumor cells frequently escape from CD8+ T cell recognition by abrogating MHC-I antigen presentation. Deficiency in processing components, like the transporter associated with antigen processing (TAP), results in strongly decreased surface display of peptide/MHC-I complexes. We previously identified a class of hidden self-antigens known as T cell epitopes associated with impaired peptide processing (TEIPP), which emerge on tumor cells with such processing defects. In the present study, we analyzed thymus selection and peripheral behavior of T cells with specificity for the prototypic TEIPP antigen, the "self" TRH4 peptide/Db complex. TEIPP T cells were efficiently selected in the thymus, egressed with a naive phenotype, and could be exploited for immunotherapy against immune-escaped, TAP-deficient tumor cells expressing low levels of MHC-I (MHC-Ilo). In contrast, overt thymus deletion and functionally impaired TEIPP T cells were observed in mice deficient for TAP1 due to TEIPP antigen presentation on all body cells in these mice. Our results strongly support the concept that TEIPPs derive from ubiquitous, nonmutated self-antigens and constitute a class of immunogenic neoantigens that are unmasked during tumor immune evasion. These data suggest that TEIPP-specific CD8+ T cells are promising candidates in the treatment of tumors that have escaped from conventional immunotherapies.
Corrigendum to “Pegylated interferon plus ribavirin in HIV-infected patients with recurrent hepatitis C after liver transplantation: A prospective cohort study” [J Hepatol 2015;62:92–100]
Authors: Lluis Castells, Antoni Rimola, Christian Manzardo, Andrés Valdivieso, José Luis Montero, Rafael Barcena, Manuel Abradelo, Xavier Xiol, Victoria Aguilera, Magdalena Salcedo, Manuel Rodriguez, Carmen Bernal, Francisco Suarez, Antonio Antela, Sergio Olivares, Santos del Campo, Montserrat Laguno, José R. Fernandez, Gloria de la Rosa, Fernando Agüero, Iñaki Perez, Juan Gonzàlez-García, Juan I. Esteban-Mur, Jose M. Miro
Journal: Journal of Hepatology (2015)
Effect of pentavalent rotavirus vaccine introduction on hospital admissions for diarrhoea and rotavirus in children in Rwanda: a time-series analysis
Authors: Fidele Ngabo, Jacqueline E Tate, Maurice Gatera, Celse Rugambwa, Philippe Donnen, Philippe Lepage, Jason M Mwenda, Agnes Binagwaho, Umesh D Parashar
Journal: The Lancet Global Health (2016)

<h2>Summary</h2><h3>Background</h3> In May, 2012, Rwanda became the first low-income African country to introduce pentavalent rotavirus vaccine into its routine national immunisation programme. Although the potential health benefits of rotavirus vaccination are huge in low-income African countries that account for more than half the global deaths from rotavirus, concerns remain about the performance of oral rotavirus vaccines in these challenging settings. <h3>Methods</h3> We conducted a time-series analysis to examine trends in admissions to hospital for non-bloody diarrhoea in children younger than 5 years in Rwanda between Jan 1, 2009, and Dec 31, 2014, using monthly discharge data from the Health Management Information System. Additionally, we reviewed the registries in the paediatric wards at six hospitals from 2009 to 2014 and abstracted the number of total admissions and admissions for diarrhoea in children younger than 5 years by admission month and age group. We studied trends in admissions specific to rotavirus at one hospital that had undertaken active rotavirus surveillance from 2011 to 2014. We assessed changes in rotavirus epidemiology by use of data from eight active surveillance hospitals. <h3>Findings</h3> Compared with the 2009–11 prevaccine baseline, hospital admissions for non-bloody diarrhoea captured by the Health Management Information System fell by 17–29% from a pre-vaccine median of 4051 to 2881 in 2013 and 3371 in 2014, admissions for acute gastroenteritis captured in paediatric ward registries decreased by 48–49%, and admissions specific to rotavirus captured by active surveillance fell by 61–70%. The greatest effect was recorded in children age-eligible to be vaccinated, but we noted a decrease in the proportion of children with diarrhoea testing positive for rotavirus in almost every age group. <h3>Interpretation</h3> The number of admissions to hospital for diarrhoea and rotavirus in Rwanda fell substantially after rotavirus vaccine implementation, including among older children age-ineligible for vaccination, suggesting indirect protection through reduced transmission of rotavirus. These data highlight the benefits of routine vaccination against rotavirus in low-income settings. <h3>Funding</h3> Gavi, the Vaccine Alliance and the Government of Rwanda.
Rapid decline of fasting glucose in HCV diabetic patients treated with direct-acting antiviral agents
Authors: P. Pavone, T. Tieghi, G. d'Ettorre, M. Lichtner, R. Marocco, I. Mezzaroma, G. Passavanti, P. Vittozzi, C.M. Mastroianni, V. Vullo
Journal: Clinical Microbiology and Infection (2016)
Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome
Authors: Sabina A. Murphy, Christopher P. Cannon, Michael A. Blazing, Robert P. Giugliano, Jennifer A. White, Yuliya Lokhnygina, Craig Reist, KyungAh Im, Erin A. Bohula, Daniel Isaza, Jose Lopez-Sendon, Mikael Dellborg, Uma Kher, Andrew M. Tershakovec, Eugene Braunwald
Journal: Journal of the American College of Cardiology (2016)
Clinical trials with MRNA electroporated dendritic cells for stage III/IV melanoma patients
Authors: Sofie Wilgenhof, Jurgen Corthals, Carlo Heirman, Bart Neyns, Kris Thielemans
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts TriMixDC-MEL consists of autologous monocyte-derived DC that are electroporated with synthetic mRNA encoding CD40 ligand, a constitutively active TLR4, CD70 and fusion proteins of DC.LAMP with 4 melanoma associated antigens (MAGE-A3, MAGE-C2, tyrosinase and gp100). TriMixDC-MEL
Nicotine patches may not be safe
Authors: M. R Arnaot
Journal: BMJ (1995)

EDITOR,—In their first article on recent advances in cardiology John McMurray and Andrew Rankin imply that the use of transdermal nicotine patches is completely safe in patients with coronary heart disease.1 Serious, sometimes fatal cases of atrial fibrillation and myocardial infarction have, however, been reported after using such patches in patients with and without a history of heart disease, particularly when patients have smoked while using the patch.2 Two such cases were reported recently to the Dutch Bureau …
Cyclosporine A in Reperfused Myocardial Infarction
Authors: Filippo Ottani, Roberto Latini, Lidia Staszewsky, Luigi La Vecchia, Nicola Locuratolo, Marco Sicuro, Serge Masson, Simona Barlera, Valentina Milani, Mario Lombardi, Alessandra Costalunga, Nadia Mollichelli, Andrea Santarelli, Nicoletta De Cesare, Paolo Sganzerla, Alberto Boi, Aldo Pietro Maggioni, Ugo Limbruno
Journal: Journal of the American College of Cardiology (2016)
Viraemia, immunogenicity, and survival outcomes of cytomegalovirus chimeric epitope vaccine supplemented with PF03512676 (CMVPepVax) in allogeneic haemopoietic stem-cell transplantation: randomised phase 1b trial
Authors: Ryotaro Nakamura, Corinna La Rosa, Jeffrey Longmate, Jennifer Drake, Cynthia Slape, Qiao Zhou, Melanie G Lampa, Margaret O'Donnell, Ji-Lian Cai, Len Farol, Amandeep Salhotra, David S Snyder, Ibrahim Aldoss, Stephen J Forman, Jeffrey S Miller, John A Zaia, Don J Diamond
Journal: The Lancet Haematology (2015)
Intervention on inhalation technique of rotahaler in patients with chronic obstructive pulmonary disease and asthma
Authors: G.M. Khan, Paudel Badri, Thapa Parbati, Duwal Anita, Adhikari Atul, Paudel Deepak, Regmi Dipendra, Barakoti Himal, Gwachha Kabita, Koju Nirmala
Journal: Asian Journal of Pharmaceutical Sciences (2015)
Rational Design of Targeted Next-Generation Carriers for Drug and Vaccine Delivery
Authors: Balaji Narasimhan, Jonathan T. Goodman, Julia E. Vela Ramirez
Journal: Annual Review of Biomedical Engineering (2016)

Pattern recognition receptors on innate immune cells play an important role in guiding how cells interact with the rest of the organism and in determining the direction of the downstream immune response. Recent advances have elucidated the structure and function of these receptors, providing new opportunities for developing targeted drugs and vaccines to treat infections, cancers, and neurological disorders. C-type lectin receptors, Toll-like receptors, and folate receptors have attracted interest for their ability to endocytose their ligands or initiate signaling pathways that influence the immune response. Several novel technologies are being developed to engage these receptors, including recombinant antibodies, adoptive immunotherapy, and chemically modified antigens and drug delivery vehicles. These active targeting technologies will help address current challenges facing drug and vaccine delivery and lead to new tools to treat human diseases.
Effect of participatory women's groups facilitated by Accredited Social Health Activists on birth outcomes in rural eastern India: a cluster-randomised controlled trial
Authors: Prasanta Tripathy, Nirmala Nair, Rajesh Sinha, Shibanand Rath, Raj Kumar Gope, Suchitra Rath, Swati Sarbani Roy, Aparna Bajpai, Vijay Singh, Vikash Nath, Sarfraz Ali, Alok Kumar Kundu, Dibakar Choudhury, Sanjib Kumar Ghosh, Sanjay Kumar, Rajendra Mahapatra, Anthony Costello, Edward Fottrell, Tanja A J Houweling, Audrey Prost
Journal: The Lancet Global Health (2016)

A quarter of the world's neonatal deaths and 15% of maternal deaths happen in India. Few community-based strategies to improve maternal and newborn health have been tested through the country's government-approved Accredited Social Health Activists (ASHAs). We aimed to test the effect of participatory women's groups facilitated by ASHAs on birth outcomes, including neonatal mortality.In this cluster-randomised controlled trial of a community intervention to improve maternal and newborn health, we randomly assigned (1:1) geographical clusters in rural Jharkhand and Odisha, eastern India to intervention (participatory women's groups) or control (no women's groups). Study participants were women of reproductive age (15-49 years) who gave birth between Sept 1, 2009, and Dec 31, 2012. In the intervention group, ASHAs supported women's groups through a participatory learning and action meeting cycle. Groups discussed and prioritised maternal and newborn health problems, identified strategies to address them, implemented the strategies, and assessed their progress. We identified births, stillbirths, and neonatal deaths, and interviewed mothers 6 weeks after delivery. The primary outcome was neonatal mortality over a 2 year follow up. Analyses were by intention to treat. This trial is registered with ISRCTN, number ISRCTN31567106.Between September, 2009, and December, 2012, we randomly assigned 30 clusters (estimated population 156 519) to intervention (15 clusters, estimated population n=82 702) or control (15 clusters, n=73 817). During the follow-up period (Jan 1, 2011, to Dec 31, 2012), we identified 3700 births in the intervention group and 3519 in the control group. One intervention cluster was lost to follow up. The neonatal mortality rate during this period was 30 per 1000 livebirths in the intervention group and 44 per 1000 livebirths in the control group (odds ratio [OR] 0.69, 95% CI 0·53-0·89).ASHAs can successfully reduce neonatal mortality through participatory meetings with women's groups. This is a scalable community-based approach to improving neonatal survival in rural, underserved areas of India.Big Lottery Fund (UK).
Micafungin Versus Fluconazole Or Itraconazole For Prophylaxis Against Invasive Fungal Infections During Neutropenia In Patients Undergoing Haplo-Identical Hematopoietic Stem Cell Transplantation
Authors: el-Cheikh Jean, Crocchiolo Roberto, Fürst Sabine, Bramanti Stefania, Sarina Barbara, Granata Angela, Faucher Catherine, Mohty Bilal, Bouabdallah Reda, Norbert Vey, Christian Chabannon, Santoro Armando, Blaise Didier, Castagna Luca, Harbi Samia, Didier Blaise
Journal: Blood (2013)
Magnetic nanocomposite scaffolds combined with static magnetic field in the stimulation of osteoblastic differentiation and bone formation
Authors: Hyung-Mun Yun, Su-Jin Ahn, Kyung-Ran Park, Mi-Joo Kim, Jung-Ju Kim, Guang-Zhen Jin, Hae-Won Kim, Eun-Cheol Kim
Journal: Biomaterials (2016)
P0768 : Late mortality in treatment-experienced cirrhotic patients treated with triple therapy including boceprevir or telaprevir in a real-life cohort - ANRS Co 20 cupic
Authors: J.-P. Bronowicki, H. Fontaine, C. Dufour, F. Zoulim, D. Larrey, V. Canva, D. Samuel, T. Poynard, P. Marcellin, V. De Ledinghen, M. Bourlière, L. Alric, J.-P. Zarski, J.-J. Raabe, L. Serfaty, S. Metivier, G. Riachi, A. Abergel, V. Loustaud-Ratti, X. Causse, D. Guyader, P.-H. Bernard, P. Attali, V. Di Martino, P. Cacoub, P. Cales, A. Tran, I. Rosa, V. Grando-Lemaire, I. Portal, T. Dao, D. Lucidarme, T. Fontanges, Y. Barthe, J.-M. Pawlotsky, S. Pol, F. Carrat, C. Hezode
Journal: Journal of Hepatology (2015)
Abstract 14608: Impact of Phospho-Calcic Metabolism and Calcium Supplements on Bioprosthetic Valve Calcification Assessed by Computed Tomography
Authors: Haifa Mahjoub, Patrick Mathieu, Eric Larose, Abdelaziz Dahou, Mario Senechal, Jean-Gaston Dumesnil, Jean-Pierre Despres, Philippe Pibarot
Journal: Circulation (2013)

Background: Cusp calcification is the main mechanism leading to structural degeneration of bioprosthetic heart valves (BPVs). Recent studies suggest that BPV calcification is an active rather than passive process probably modulated by several mechanisms including lipid mediated inflammation and dysfunctional phospho-calcic metabolism. The objective of this prospective study was to identify the clinical and metabolic determinants of BPV calcification assessed by multi-detector computed tomography (CT). Methods and results: Presence of BPV calcification was assessed by CT in 194 consecutive patients with an aortic BPV. Patients also underwent a clinical evaluation with a detailed record of medications, a Doppler-echocardiographic exam and a complete blood lipid and plasma phospho-calcic profile. Forty-six (46) pts (24%) had evidence of BPV calcification (cusp calcification score >0 mm3). Patients with BPV calcification had similar plasma levels of calcium (2.37±0.01mmol/l vs. 2.34 ±0.07mmol/l, p=0.1) and ph...
IGN004 is an antibody-interferon-alpha fusion protein against a novel tumor-associated antigen with both direct anti-tumor and immunostimulatory effects
Authors: Kristopher K Steward, Raj K Sachdev, Michael J Gresser, Sanjay D Khare
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Antibody-interferon-alpha (IFNα) fusion proteins represent a cancer therapeutic with properties of an antibody-drug conjugate and an immunotherapy, having both direct anti-tumor and immune-activating effects. We report the anti-tumor activity of IGN004, an antibody-IFNα fusion
Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis
Authors: Xue Wang, Wen Sun, Weifeng Shen, Mingyang Xia, Cheng Chen, Daimin Xiang, Beifang Ning, Xiuliang Cui, Hengyu Li, Xiaofeng Li, Jin Ding, Hongyang Wang
Journal: Journal of Hepatology (2016)
Effect of a School-Based Water Intervention on Child Body Mass Index and Obesity
Authors: Amy Ellen Schwartz, Michele Leardo, Siddhartha Aneja, Brian Elbel
Journal: JAMA Pediatrics (2016)

Decreasing the amount of caloric beverages consumed and simultaneously increasing water consumption is important to promoting child health and decreasing the prevalence of childhood obesity.To estimate the impact of water jets (electrically cooled, large clear jugs with a push lever for fast dispensing) on standardized body mass index, overweight, and obesity in elementary school and middle school students. Milk purchases were explored as a potential mechanism for weight outcomes.This quasi-experimental study used a school-level database of cafeteria equipment deliveries between the 2008-2009 and 2012-2013 and included a sample of 1227 New York, New York, public elementary schools and middle schools and the 1,065,562 students within those schools.Installation of water jets in schools.Individual body mass index (BMI) was calculated for all students in the sample using annual student-level height and weight measurements collected as part of New York's FITNESSGRAM initiative. Age- and sex-specific growth charts produced by the Centers for Disease Control and Prevention were used to categorize students as overweight and obese. The hypothesis that water jets would be associated with decreased standardized BMI, overweight, and obesity was tested using a difference-in-difference strategy, comparing outcomes for treated and nontreated students before and after the introduction of a water jet.This study included 1 065 562 students within New York City public elementary schools and middle schools. There was a significant effect of water jets on standardized BMI, such that the adoption of water jets was associated with a 0.025 (95% CI, -0.038 to -0.011) reduction of standardized BMI for boys and a 0.022 (95% CI, -0.035 to -0.008) reduction of standardized BMI for girls (P < .01). There was also a significant effect on being overweight. Water jets were associated with a 0.9 percentage point reduction (95% CI, 0.015-0.003) in the likelihood of being overweight for boys and a 0.6 percentage reduction (95% CI, 0.011-0.000) in the likelihood of being overweight for girls (P < .05). We also found a 12.3 decrease (95% CI, -19.371 to -5.204) in the number of all types of milk half-pints purchased per student per year (P < .01).Results from this study show an association between a relatively low-cost water availability intervention and decreased student weight. Milk purchases were explored as a potential mechanism. Additional research is needed to examine potential mechanisms for decreased student weight, including reduced milk taking, as well as assessing impacts on longer-term outcomes.
Quantifying prion disease penetrance using large population control cohorts
Authors: Eric Vallabh Minikel, Sonia M. Vallabh, Monkol Lek, Karol Estrada, Kaitlin E. Samocha, J. Fah Sathirapongsasuti, Cory Y. McLean, Joyce Y. Tung, Linda P. C. Yu, Pierluigi Gambetti, Janis Blevins, Shulin Zhang, Yvonne Cohen, Wei Chen, Masahito Yamada, Tsuyoshi Hamaguchi, Nobuo Sanjo, Hidehiro Mizusawa, Yosikazu Nakamura, Tetsuyuki Kitamoto, Steven J. Collins, Alison Boyd, Robert G. Will, Richard Knight, Claudia Ponto, Inga Zerr, Theo F. J. Kraus, Sabina Eigenbrod, Armin Giese, Miguel Calero, Jesús de Pedro-Cuesta, Stéphane Haïk, Jean-Louis Laplanche, Elodie Bouaziz-Amar, Jean-Philippe Brandel, Sabina Capellari, Piero Parchi, Anna Poleggi, Anna Ladogana, Anne H. O’Donnell-Luria, Konrad J. Karczewski, Jamie L. Marshall, Michael Boehnke, Markku Laakso, Karen L. Mohlke, Anna Kähler, Kimberly Chambert, Steven McCarroll, Patrick F. Sullivan, Christina M. Hultman, Shaun M. Purcell, Pamela Sklar, Sven J. van der Lee, Annemieke Rozemuller, Casper Jansen, Albert Hofman, Robert Kraaij, Jeroen G. J. van Rooij, M. Arfan Ikram, André G. Uitterlinden, Cornelia M. van Duijn, Mark J. Daly, Daniel G. MacArthur
Journal: Science Translational Medicine (2016)

Large genomic reference data sets reveal a spectrum of pathogenicity in the prion protein gene and provide genetic validation for a therapeutic strategy in prion disease.
Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice
Authors: So Yun Min, Jamie Kady, Minwoo Nam, Raziel Rojas-Rodriguez, Aaron Berkenwald, Jong Hun Kim, Hye-Lim Noh, Jason K Kim, Marcus P Cooper, Timothy Fitzgibbons, Michael A Brehm, Silvia Corvera
Journal: Nature Medicine (2016)
Interferon (-alpha, -beta, and -omega) receptor 2 (IFNAR2) is a prognostic biomarker for lung cancer
Authors: Nobuhisa Ishikawa, Noboru Hattori, Sonosuke Tanaka, Yasushi Horimasu, Akihito Yokoyama, Nobuoki Kohno
Journal: European Respiratory Journal (2011)

Background: The type I interferon receptor subunit, interferon (-alpha, -beta, and –omega) receptor 2 (IFNAR2), has been reported to be overexpressed in several malignancies, primarily adenocarcinomas (ADCs). However, the biological significance of IFNAR2 in human lung cancer has not yet been studied.

Methods: Immunohistochemical analysis of 113 surgically resected non-small cell lung cancer specimens was performed. Serum concentrations of IFNAR2 were also determined by an enzyme-linked immunosorbent assay in 157 lung cancer patients and 164 healthy volunteers.

Results: IFNAR2 overexpression was observed in all histological types of lung cancers examined. Furthermore, strong IFNAR2 expression was associated with shorter progression-free survival (PFS) and overall survival (OS) (p < 0.0001 and p =0.0110, respectively) in non-small cell lung cancer patients. Multivariate analyses confirmed its independent prognostic value for PFS and OS (p < 0.0001 and p= 0.0222, respectively). IFNAR2 serum levels were also significantly higher in lung cancer patients than in healthy volunteers (p < 0.0001).

Conclusions: IFNAR2 overexpression was observed in various histological types of lung cancers, and appears to be associated with lung cancers that behave aggressively. The results of this study strongly support the potential of IFNAR2 as a diagnostic and prognostic biomarker for lung cancer.