tbuckley/cabot-search huggingface dataset:
In Vitro and In Vivo Transglutaminase 2 Expression in Asthma and COPD
Authors: Gyu-Young Hur, Jee Youn Oh, Jae-Kyeom Sim, Kyung Hoon Min, Sung-Yong Lee, Jae-Jeong Shim, Kyung-Ho Kang
Journal: Journal of Allergy and Clinical Immunology (2016)
Pathologic Abnormalities Behind Ductal Carcinoma In Situ Terminology
Authors: Elliott Foucar
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Allogeneic Stem Cell Transplantation For Acute Myeloid Leukemia With Normal Cytogenetics (CN-AML): Outcome, Risk Factors and Role Of Molecular Subgroups In 752 Patients – A Report From The Acute Leukemia Working Party Of EBMT
Authors: Christoph Schmid, Myriam Labopin, Gérard Socié, Alessandro Rambaldi, Rainer Schwerdtfeger, Eric Deconinck, Stephane Vigouroux, Anne Huynh, Liisa Volin, Jean-Henri Bourhis, Johan Maertens, Patrice Chevalier, Pavel Jindra, Günther Schlimok, Jan Cornelissen, Norbert Ifrah, Arnon Nagler, Emmanuelle Polge, Jordi Esteve, Mohamad Mohty
Journal: Blood (2013)
Evaluation of SQ-House Dust Mite Sublingual Immunotherapy Tablet One-Year after Completion of a 24-Week Treatment Period
Authors: Petra U. Zieglmayer, Hendrik Nolte, Harold S. Nelson, David I. Bernstein, Amarjot Kaur, Ziliang Li, Rene Zieglmayer, Rene Schmutz, Patrick Lemell, Friedrich Horak
Journal: Journal of Allergy and Clinical Immunology (2016)
Abstract MP075: Fetuin-A and Risk of Ischemic Stroke Among Women
Authors: Monik C Jimenez, Qi Sun, Frank B Hu, JoAnn E Manson, Kathryn M Rexrode
Journal: Circulation (2012)

Introduction: Fetuin-A, a protein secreted primarily by the liver, has been associated with non-alcoholic fatty liver disease and insulin resistance. A recent study found that high fetuin-A levels were associated with increased cardiovascular risk, particularly for ischemic stroke; however, the data have not been replicated. Methods: A nested case-control design was utilized to examine the relationship between fetuin-A and ischemic stroke among female participants of the Nurses’ Health Study who provided blood samples. A total of 462 incident cases of ischemic stroke were identified and confirmed by medical records according to the National Survey of Stroke criteria between 1990-2006 and were matched to 462 controls by age, menopausal status, hormone therapy use, and smoking status. Fetuin-A was measured on blood samples collected and stored between 1989-1990. Conditional logistic regression was used to evaluate the multivariable adjusted association between fetuin-A and ischemic stroke. Results: Fetuin-A levels were higher in those with elevated cholesterol (p=0.02), current hormone use (p=0.002) and hypertension (p=0.05) in univariate analyses. Significant partial spearman correlations, adjusted for matching factors, were found between fetuin-A and triglycerides (r=0.18; p&lt;0.001), C-reactive protein (r=0.12; p=0.002), and BMI (r=0.13; p&lt;0.001). Fetuin-A quartiles were not significantly associated with increased risk of incident ischemic stroke when adjusted for matching factors, or when additionally adjusted for other CVD risk factors (see Table 1). Further adjustment for other biomarkers, modestly strengthened the association, but p for trend remained nonsignificant (p=0.37). Conclusions: In this population of women, fetuin-A was not significantly associated with a greater risk of ischemic stroke. Further research is needed to explore this association. Table 1 Multivariable adjusted relative risk (95% CI) of ischemic stroke by Fetuin-A quartiles Quartiles of Fetuin-A p-value for trend Q1 Q2 Q3 Q4 Range (μ g/mL) &lt;377 377-&lt;449 449-&lt;526 526-1538 Cases/Controls 108/116 136/115 102/113 112/116 Model 1 * 1.00 1.22 (0.86-1.75) 0.92 (0.62-1.35) 1.05 (0.71-1.55) 0.79 Model 2 † 1.00 1.32 (0.88-1.99) 1.00 (0.64-1.56) 1.28 (0.81-2.01) 0.52 Model 3 ‡ 1.00 1.34 (0.88-2.03) 1.06 (0.67-1.69) 1.24 (0.78-1.98) 0.59 Model 4 § 1.00 1.41 (0.82-2.42) 1.00 (0.55-1.84) 1.33 (0.73-2.42) 0.37 * Model 1: Conditional on matching factors (age, menopausal status, hormone use, smoking) † Model 2: Model 1 + aspirin use, alcohol intake, physical activity, healthy diet score, current post-menopausal hormone use ‡ Model 3: Model 2 + aspirin use, alcohol intake, physical activity, healthy diet score, current post-menopausal hormone use, history of diabetes, elevated cholesterol, high blood pressure, and CHD or revascularization. § Model 4: Model 3+ HbA1c, ln(CRP), ln(triglycerides), ln(cholesterol/HDL)
Phase 1 study of intra-arterial hepatic (IAH) delivery of doxorubicin-transdrug (DT) for patients with advanced hepatocellular carcinoma (HCC)
Authors: P. Merle, S. Si Ahmed, F. Habersetzer, A. Abergel, J. Taieb, L. Bonyhay, D. Costantini, J. Dufour-Lamartinie, C. Trepo
Journal: Journal of Clinical Oncology (2006)

14094 Background: HCC is a highly chemoresistant due to MDR efflux pumps. DT is a newly cytotoxic chemotherapy composed of doxorubicin-loadded polyisohexylcyanoacrylate nanoparticles, allowing doxorubicin to overcome MDR pumps [Barraud, J Hepatol 2005; 42: 736]. Methods: 16 cirrhotic patients (pts) of Child-Pugh A with advanced HCC, transaminases/GGT &lt;5N, platelets &gt;100000/mm 3 , neutrophiles &gt;1500/mm 3 , were enrolled in a multicentric noncontrolled study. A single IAH injection of 10, 20, 30, 35, or 40mg/m2 DT (respectively 3,3,4, and 3 pts) was performed, tolerance and efficacy being assessed 4 weeks later. Results: Grade 4 neutropenia (2pts at 40mg/m2) gave the Maximal Tolerated Dose. Grade 2–3 hypertransaminasemia (transient) occurred dose-independently. Two serious adverse events (SAE) were hypotension and acute respiratory distress syndrome. All adverse events (AE) (90% grade 1–2) occurring during injection were dose-independent, and completely and fastly recovered : cough (6pts), dyspnea (2pts), SaO2 decrease (2pts), tachycardia (2pts), bradycardia (2pts), hypotension (2pts). Anti-tumor efficacy of DT was evaluated by helicoidal CT-scan with contrast injection 4 weeks after injection : 3pts (20%) showed partial response with frank decrease of contrast enhancement at arterial perfusion, 8pts (50%) remained stable, and 5pts (30%) had progression. Conclusions: This phase 1 showed that a single IAH injection of DT was safe until 35 mg/m2 for Child-Pugh A patients with advanced HCC. This dosage will be retained for the phase 2 step comprising 3 injections at 4-week intervals which will aim at confirming the antitumour efficacy of DT for HCC. [Table: see text]
UK guidelines for the management of acute pancreatitis
Journal: Gut (2005)

DiagnosisN *The correct diagnosis of acute pancreatitis should be made in all patients within 48 hours of admission (recommendation grade C).N The aetiology of acute pancreatitis should be determined in at least 80% of cases and no more than 20% should be classified as idiopathic (recommendation grade B).N Although amylase is widely available and provides acceptable accuracy of diagnosis, where lipase estimation is available it is preferred for the diagnosis of acute pancreatitis (recommendation grade A).N Where doubt exists, imaging may be used: ultrasonography is often unhelpful and pancreatic imaging by contrast enhanced computed tomography provides good evidence for the presence or absence of pancreatitis (recommendation grade C). AssessmentN The definitions of severity, as proposed in the Atlanta criteria, should be used.However, organ failure present within the first week, which resolves within 48 hours, should not be considered an indicator of a severe attack of acute pancreatitis (recommendation grade B).N Available prognostic features which predict complications in acute pancreatitis are clinical impression of severity, obesity, or APACHE II.8 in the first 24 hours of admission, and C reactive protein .150mg/l, Glasgow score 3 or more, or persisting organ failure after 48 hours in hospital (recommendation grade B).N Patients with persisting organ failure, signs of sepsis, or deterioration in clinical status 6-10 days after admission will require computed tomography (recommendation grade B). Prevention of complicationsN The evidence to enable a recommendation about antibiotic prophylaxis against infection of pancreatic necrosis is conflicting and difficult to interpret.Some trials show benefit, others do not.At present there is no consensus on this issue.N If antibiotic prophylaxis is used, it should be given for a maximum of 14 days (recommen-dation grade B).Further studies are needed (recommendation grade C).
Development of a Germ-Free Murine Model for Prediction of Food Allergen Potency: Preliminary Studies Using Peanut Ara h1 and Ara h2 As Model Food Allergens
Authors: Nathan L. Marsteller, Kwame Andoh-Kumi, Stef J. Koppelman, Richard E. Goodman, Joe L. Baumert
Journal: Journal of Allergy and Clinical Immunology (2016)
Low yield of screening asylum seekers from countries with a tuberculosis incidence of &lt;50 per 100 000 population
Authors: Gerard de Vries, Job van Rest, Wieneke Meijer, Bert Wolters, Rob van Hest
Journal: European Respiratory Journal (2016)

In low tuberculosis (TB) incidence countries foreign-born patients constitute a high percentage of the TB burden, up to 90% in Scandinavian countries [1] and 73% in the Netherlands in 2014 [2]. Several European Union (EU) countries have developed screening strategies to identify TB in migrants at an early stage and prevent transmission, but there is no uniform EU policy [3–5]. In the Netherlands, TB screening of migrants has been stipulated in the Alien's Act since 1966. At that time, screening was mainly carried out for migrant workers from Southern European countries, Morocco and Turkey. Since the 1990s, TB screening has increasingly included immigrants and asylum seekers from other countries in the world. For the screening of asylum seekers a mobile radiography screening programme has been in place since 1992 with national coverage [6]. The annual overall yield of TB screening has been well above 200 cases per 100 000 persons screened until a few years ago [6, 7]. It declined to 85 cases per 100 000 persons screened in 2014, due to the high number of asylum seekers from countries with traditionally low TB incidence rates such as Iran, Iraq and, predominantly, Syria [2]. Screening asylum seekers from areas with a TB incidence of <50 per 100 000 had a low yield in the Netherlands <http://ow.ly/Yf2PT>
Microsatellite allele frequencies in humans and chimpanzees, with implications for constraints on allele size.
Authors: J C Garza, M Slatkin, N B Freimer
Journal: Molecular Biology and Evolution (1995)

The distributions of allele sizes at eight simple-sequence repeat (SSR) or microsatellite loci in chimpanzees are found and compared with the distributions previously obtained from several human populations. At several loci, the differences in average allele size between chimpanzees and humans are sufficiently small that there might be a constraint on the evolution of average allele size. Furthermore, a model that allows for a bias in the mutation process shows that for some loci a weak bias can account for the observations. Several alleles at one of the loci (Mfd 59) were sequenced. Differences between alleles of different lengths were found to be more complex than previously assumed. An 8-base-pair deletion was present in the nonvariable region of the chimpanzee locus. This locus contains a previously unrecognized repeated region, which is imperfect in humans and perfect in chimpanzees. The apparently greater opportunity for mutation conferred by the two perfect repeat regions in chimpanzees is reflected in the higher variance in repeat number at Mfd 59 in chimpanzees than in humans. These data indicate that interspecific differences in allele length are not always attributable to simple changes in the number of repeats.
Raynauds disease and the oral contraceptive pill. (Letter to the editor.)
Authors: Eastcott Hh
Journal: BMJ (1976)

Your reply to this question (July 17 p. 156) is an oversimplification which though it may be true in primary Raynauds disease takes no account of the problem that may be arising in patients who are developing the secondary condition.  My own experience has shown that apparently typical primary cases in young women coincided in their onset with the taking of ovarian steroids.  2 girls proved to be diabetic and 1 has since shown unmistakeable evidence of scleroderma.  In all cases there was an improvement when the pill was stopped.(FULL TEXT)
Why would anyone want to believe in Big Gods?
Authors: Inti A. Brazil, Miguel Farias
Journal: Behavioral and Brain Sciences (2016)

Abstract We suggest an alternative explanation for the emergence of Big Gods that places less emphasis on the role of cognitive tendencies and selection of prosocial cultural variants. Instead, we argue that the fundamental motivation to reduce uncertainty and increase long-term predictability provides a better account for the rise of Big moralizing Gods in a complex and heavily regulated social environment.
A Classification of Virus Particles Based on Morphology
Authors: J D ALMEIDA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inaccurate Reporting of Insulin Reimbursement
Authors: Carlos I. Alatorre, Eric H. Schultz
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Three Recurrent Episodes of Apical-Ballooning Takotsubo Cardiomyopathy in a Man
Authors: Mattia Cattaneo, Marco Moccetti, Elena Pasotti, Francesco Faletra, Alessandra P. Porretta, Richard Kobza, Augusto Gallino
Journal: Circulation (2015)

A 66-year-old man was admitted to the emergency room because of 3-hour-long acute chest pain with dyspnea and nausea while fishing on a high-altitude (2400 m) lake in the very early morning.The patient was transferred by helicopter.Persistent chest pain without pathological clinical findings (Spo2, 99%; shock index, 0.9; axillary temperature, 36.7℃) was present.Medical history revealed no previous cardiovascular events and no further cardiovascular risk factors except smoking (40 packs a year).ECG demonstrated ST-segment elevation (Figure 1A).ST-segment-elevation acute coronary syndrome was initially suspected.Immediate selective coronary angiography demonstrated neither stenosis nor dissections.Ventriculography showed extensive left ventricular (LV) apical and midventricular akinesia with hyperkinesia in the basal segments and a moderate reduction in the estimated LV ejection fraction (Figure 1B and Movie I in the online-only Data Supplement).These large LV wall motion abnormalities were inconsistent with slightly elevated cardiac enzymes (troponin I, 0.48 μg/L [normal, <0.09 μg/L]; creatine kinase-MB, 18.7 UI/L [normal, <24 UI/L]).Clinical presentation and the absence of elevation of inflammation markers elevation and pathological viral tests and bacterial cultures made it possible to reasonably exclude acute myocarditis.ECG repolarization alteration (Figure 1C) and LV wall motion abnormalities recovered spontaneously and fully in 4 days (Figure 1D and Movie II in the online-only Data Supplement).Therefore, the diagnosis of apical-ballooning takotsubo cardiomyopathy (TTC) was made.
Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges
Authors: Dinh Ha, Ningning Yang, Venkatareddy Nadithe
Journal: Acta Pharmaceutica Sinica B (2016)

Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles; exosomes are non-immunogenic in nature due to similar composition as body׳s own cells. In this article, the origin and structure of exosomes as well as their biological functions are outlined. We will then focus on specific applications of exosomes as drug delivery systems in pharmaceutical drug development. An overview of the advantages and challenges faced when using exosomes as a pharmaceutical drug delivery vehicles will also be discussed.
Spur cell anemia in the setting of progressive liver allograft failure
Authors: Daniel K. Partain, Juliana Perez Botero, Min Shi, John J. Poterucha, Aneel A. Ashrani, Carrie A. Thompson
Journal: American Journal of Hematology (2016)

Image 1. Peripheral blood smear, Wright-Giemsa X100 showing multiple spur cells (red blood cells with narrow based spicules that are unevenly distributed). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] Spur cell anemia is a rare cause of anemia that has traditionally been described as a consequence of alcoholic liver cirrhosis 1 but has recently been described in patients with advanced liver disease from other causes 2. Spur cells form as a consequence of abnormal cholesterol to phospholipid ratios in red cell membranes caused by decreased apolipoproteins in the setting of liver cirrhosis 3-5. Spur cells are susceptible to splenic sequestration and destruction, and patients are generally refractory to blood transfusions because transfused cells rapidly acquire the abnormal membrane configuration 6. The only effective treatment is liver transplantation 7.
Partial breast radiotherapy is as effective as standard whole breast radiotherapy, study finds
Authors: Jacqui Wise
Journal: BMJ (2016)

Radiotherapy focused around only the part of the breast that had contained the tumour is as effective as the standard treatment of whole breast radiotherapy, shows research presented at the European Breast Cancer Conference in Amsterdam this week.1 The researchers hope that the results will contribute to changes in clinical practice worldwide.

The IMPORT LOW trial, funded by Cancer Research UK, included 2018 women with a median age of 63 who were recruited from 30 radiotherapy centres in the United Kingdom. …
Midline Destructive Lesions in a Cocaine User
Authors: Bianca M L Stelten, Bart Post
Journal: New England Journal of Medicine (2016)

A 44-year-old man with a history of cocaine use presented with a 1-year history of headache and progressive frontal syndrome. Examination revealed ophthalmoparesis due to mechanical restriction of eye movements, mild pyramidal syndrome, and a defect in the palate.
Rho-Kinase Inhibition Attenuates Airway Inflammation In An Experimental Asthma Model In Sickle Cell Mice
Authors: Flavia Rubia Pallis, Camila Bononi Almeida, Marcus Corat, Carolina Lanaro, Nicola Conran, Fernando Ferreira Costa, Carla Fernanda Franco-Penteado
Journal: Blood (2013)
<i>Notes from the Field</i>: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation — Minnesota, 2015
Authors: Pamela Talley, Stacy Holzbauer, Kirk Smith, William Pomputius
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. A rapid influenza assay was negative, and erythrocyte sedimentation rate and total white blood cell count were normal. She improved with symptomatic care at home, but returned to her pediatrician's office on April 28, reporting recurrence of her headache and photophobia and new onset of a stiff neck. She was admitted to the hospital, where she was febrile to 102.9°F (39.4°C) and had meningismus. Computed tomography scan of her head was normal, and a cerebrospinal fluid (CSF) analysis showed a markedly elevated white blood cell count with 68% lymphocytes, low glucose, and a negative Gram stain. She was treated empirically for both bacterial and herpes simplex virus meningitis. The patient's hospital course was notable for hypotension (blood pressure 81/50), irritability, and pancreatitis with a peak lipase of 8,627 U/L. CSF cultures yielded no growth, and CSF polymerase chain reaction (PCR) testing for herpes simplex virus was negative. Nucleic acid amplification testing, acid-fast bacilli stain, and acid-fast bacilli cultures of CSF were negative for Mycobacterium tuberculosis. Results of investigations for human immunodeficiency virus, syphilis, Lyme disease, human herpesvirus 6 and 7, and species of Babesia, Toxoplasma, Histoplasma, Cryptococcus, Blastomyces, and Brucella were negative. She recovered and was discharged on hospital day 11 with no apparent sequelae.