tbuckley/cabot-search huggingface dataset:
PTU-171 Buried Barrett’S Dysplasia (‘Bbad’) Study: Results from a long Term follow up Study of Barrett’S Neoplasia Cohort: Abstract PTU-171 Table 1
Authors: S Tholoor, R Bhattacharyya, O Tsagkournis, P Basford, P Bhandari
Journal: Gut (2013)

<h3>Introduction</h3> Buried Barrett’s’ or Subsquamous intestinal metaplasia (SSIM) refers to glands which are ‘buried’ underneath the squamous epithelium. High dose acid suppressive therapy and lack of acid exposure can result in squamous re-epithelialisation over the Barrett’s mucosa. Buried Barrett’s can pose significant diagnostic and surveillence challenges. Data on the prevalance of Buried Barrett’s in endoscopic therapy naïve patients is limited. Like wise there is limted data on the prevalance of Buried Barrett’s in patients following EMR. We aim to study and compare the prevalence of Buried Barrett’s in these two groups of patients. <h3>Methods</h3> Inclusion Criteria: Patients with Barrett’s referred for endoscopic treatment between June 06 and June 12 Patients with Barrett’s dysplasia following EMR procedure. Biopsy: Biopsies were first obtained from any suspicious looking area. Following this, biopsies were then obtained from the neosquamous area. Finally, random biopsies were obtained. These were sent in separate cassettes. Histopathology was reported by two independent GI pathologists and was prospectively recorded on a central pathology database. Buried Barrett’s was defined as any metaplastic or glandular tissue beneath the squamous epithelium. Pathology specimens were reported by 2 independent, accredited GI pathologists. <h3>Results</h3> <h3>Conclusion</h3> Our study shows that in the pre-EMR cohort, there was an overall prevalence of 15.7% of buried Barrett’s and a 14.5% prevalence of buried Barrett’s with high grade neoplasia (HGD or IMC). Our results in the post EMR cohort shows an overall prevalence of 33.7% of buried Barrett’s with 9.6% prevalence of buried high grade neoplasia (HGD or IMC) suggesting that a third of patients undergoing EMR for Barrett’s dysplasia harbour buried Barrett’s and a third of these patients harbour high grade neoplasia. This has significant implications for post EMR endoscopic assessment and surveillance. The results from our study shows that there is a need to develop and maintain proficiency in sampling techniques in patients with Barrett’s oesophagus. It also shows that the biopsies particularly from those with dysplasia should be carefully reviewed by gastrointestinal pathologists who devote specific attention to identifying buried Barrett’s and buried dysplasia. <h3>Disclosure of Interest</h3> None Declared
Abstract 3706: Intervention of human breast cell carcinogenesis chronically induced by 3, 4, 4’-trichlorocarbanilide.
Authors: Shilpa Sood, Shambhunath Choudhary, Hwa-Chain R. Wang
Journal: Cancer Research (2013)

Abstract The purpose of this study was to investigate the ability of antimicrobial agent 3,4,4’-trichlorocarbanilide (TCC) to induce breast cell carcinogenesis, and then identify preventive agents to intervene in TCC-induced breast cell carcinogenesis. TCC is widely used in personal care products such as bath soaps, detergents, and cleansing lotions. Recent studies suggest that TCC acts as an endocrine disruptor to enhance the ability of steroid hormones (estrogen or testosterone) to induce estrogen and androgen receptor-mediated gene expression. Due to its environmental persistence and wide use, there are concerns about TCC's possible impact on human health. To determine whether TCC exposure may contribute to the development of breast cancer, we used our chronically-induced breast cell carcinogenesis model to determine the ability of TCC to induce progressive carcinogenesis of human breast epithelial MCF10A cells to acquire cancer-associated properties. We found that chronic exposure of MCF10A cells to TCC at physiologically-achievable nanomolar levels resulted in cellular acquisition of the cancer-associated properties of reduced dependence on growth factors, anchorage independent growth, and increased cell proliferation. These cellular changes were accompanied by upregulation of the ERK pathway, Nox1-induced ROS production, and DNA damage. We also found that curcumin, a component of turmeric extracted from the rhizome of the Indian herb Curcuma longa, was able to suppress TCC-induced cellular carcinogenesis. Our study revealed, for the first time, that chronic exposure to TCC was able to induce breast cell carcinogenesis, and TCC-induced cellular carcinogenesis was preventable by curcumin. Citation Format: Shilpa Sood, Shambhunath Choudhary, Hwa-Chain R. Wang. Intervention of human breast cell carcinogenesis chronically induced by 3, 4, 4’-trichlorocarbanilide. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3706. doi:10.1158/1538-7445.AM2013-3706
Experts Mull Testing Guidelines for Family Cancers
Authors: E. Blume
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Experts Mull Testing Guidelines for Family Cancers Get access Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 24, 18 December 1991, Pages 1782–1784, https://doi.org/10.1093/jnci/83.24.1782 Published: 18 December 1991
Case 22-2015
Authors: Daniel P. Hunt, Jonathan A. Scheske, David M. Dudzinski, Sheila L. Arvikar
Journal: New England Journal of Medicine (2015)

A 20-year-old man presented with fever and a pericardial effusion. Five weeks earlier, sore throat, fever, malaise, and myalgias had developed. Broad-spectrum antibiotic therapy was administered, without improvement. A diagnosis was made.
FDA fails to monitor fast tracked drugs after approval, says US watchdog
Authors: Owen Dyer
Journal: BMJ (2016)

The US Food and Drug Administration is not properly keeping track of medicines that have reached the market after going through one of the agency’s rapid approval programs, says a report by the Government Accountability Office (GAO), the auditing service of the US Congress.1

“FDA’s data on post-market safety issues and studies were found to be incomplete, outdated, to contain inaccuracies, and to be stored in a manner that made routine, systematic analysis difficult,” the report concluded.

It said that fewer than half of the potential safety issues that had been identified during accelerated reviews, with the intention of monitoring them in the general …
Ombudsman criticised GPs
Authors: J. Warden
Journal: BMJ (1998)

The health service ombudsman for England, Scotland, and Wales has criticised GPs who remove patients from their lists too readily or without an explanation.

The ombudsman, Michael Buckley, has new powers to investigate complaints about the exercise of clinical judgment by hospital doctors and the actions of GPs. His annual report for 1997–8 includes the first cases of such complaints. He states that in future most of the complaints he will investigate are likely to involve clinical matters rather than …
SP0047 Subjective Well-Being and Growing Older with RMD
Authors: A. Antoniou
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Lecture</h3> Subjective well-being and growing older with RMD. <h3></h3> Subjective well being is considered the overall cognitive and affective evaluations of a person's life. In other words subjective well being refers to the individual's own assessment of their life satisfaction in relation to how they think and feel about certain phenomena of their life (such as social and occupational functioning). Many studies have argued that the higher the subjective well being, the better the chances are for longevity. People suffering from chronic illnesses like RMD are thought to have a vulnerable mental health and symptoms of anxiety and depression depending of the course and type of their illness. Nevertheless does RMD itself restricts the lifestyle people want to live? Or is it just the individual's thoughts and perceptions which restrict that lifestyle? How we think about certain phenomena affects the way we feel and behave. In this lecture we will go through the definition of subjective well being, how people can increase their subjective well being as they are growing older with RMD, and finally how people with RMD can change their thoughts and beliefs about their rheumatic disabilities which will enable them to accomplish more things in their everyday life. Finally people are capable to do everything as long as they have the motivation and see things from a different perspective. <b>Alexis Antoniou</b> <b>Psychologist-Psychotherapist</b> <h3>Disclosure of Interest</h3> None Declared
O2.06 * USE OF MRI FUSION FOR CT BASED INTRACRANIAL STEREOTACTIC RADIOSURGERY
Authors: H. B. Caglar, A. Y. Altinok, E. Kucukmorkoc, H. Acar, N. Kucuk
Journal: Neuro-Oncology (2014)

The aim of this study is to evaluate the reliability of MRI fusion when determining intracranial target volume when performing CT based intracranial stereotactic radiosurgery. Patients treated with CT based intracranial stereotactic radiosurgery with various diagnosis are included in the study. All patients were immobilized using stereotactic thermoplastic masks prior to simulation. The planning CT was obtained both with and without iv contrast with 1mm slice thickness. The images obtained were then fused with 3D, T1 weighted MR images with contrast by two different platforms (Eclipse 10.0, Velocity 3.0 rigid and Velocity 3.0 deformable). The target volume was contoured by the same physician in four different image sets (planning CT with iv contrast, planning CT fused with MRI by Eclipse software, planning CT fused with MRI with Velocity rigit fusion algorithm software, planning CT fused with MRI with Velocity deformeable fusion algorithm software). The target volumes delineated on planning CT with iv contrast were determined as reference volume. The intersections of all volumes delineated with three different fusion algorithms were produced and ratios of the intersections were calculated. Values close to one was determined as the unit of similarity and were compared with Paired-Samples T Test. Eight intracranial targets were evaluated. All of the targets evaluated were clearly visualized in the planning CT with iv contast. Six of these lesions were metastases while the remaining two were meningioma. The median volume of the delineated targets on the planning CT with iv contrast was 9.53 cc. The intersecting volume with three different fusion algorithms (Eclipse fusion, Velocity rigid fusion and Velocity deformeable fusion) was 8.08, 6.74 and 6.84 cc respectively. The ratios of the intersections were 1.20, 1.42 and 1.40 where all of these differences were significant (p = 0.004, p = 0.010 ve p = 0.009). Sonuç: Determining the target volume with MRI fusion when performing CT based intracranial stereotactic radiosurgery may not be very reliable compared to obtaining a planning CT with iv contrast. Careful attention must be paid to this as this might affect not only the treatment outcomes but also the late toxicity.
Veliparib Alone or in Combination with Mitomycin C in Patients with Solid Tumors With Functional Deficiency in Homologous Recombination Repair
Authors: Miguel A. Villalona-Calero, Wenrui Duan, Weiqiang Zhao, Konstantin Shilo, Larry J. Schaaf, Jennifer Thurmond, Judith A. Westman, John Marshall, Li Xiaobai, Jiuping Ji, Jeffrey Rose, Maryam Lustberg, Tanios Bekaii-Saab, Alice Chen, Cynthia Timmers
Journal: JNCI Journal of the National Cancer Institute (2016)

BRCA germline mutations are being targeted for development of PARP inhibitors. BRCA genes collaborate with several others in the Fanconi Anemia (FA) pathway. We screened cancer patients' tumors for FA functional defects then aimed to establish the safety/feasibility of administering PARP inhibitors as monotherapy and combined with a DNA-breaking agent. Patients underwent FA functional screening for the presence (or lack) of tumor FancD2 nuclear foci formation on their archival tumor material, utilizing a newly developed method (Fanconi Anemia triple-stain immunofluorescence [FATSI]), performed in a Clinical Laboratory Improvement Amendments–certified laboratory. FATSI-negative patients were selected for enrollment in a two-arm dose escalation trial of veliparib, or veliparib/mitomycin-C (MMC). One hundred eighty-five of 643 (28.7%) screened patients were FATSI-negative. Sixty-one received veliparib or veliparib/MMC through 14 dose levels. Moderate/severe toxicities included fatigue (DLT at veliparib 400mg BID), diarrhea, and thrombocytopenia. Recommended doses are 300mg BID veliparib and veliparib 200mg BID for 21 days following 10mg/m 2 MMC every 28 days. Six antitumor responses occurred, five in the combination arm (3 breast, 1 ovarian, 1 endometrial [uterine], and 1 non–small cell lung cancer). Two patients have received 36 and 60 cycles to date. BRCA germline analysis among 51 patients revealed five deleterious mutations while a targeted FA sequencing gene panel showed missense/nonsense mutations in 29 of 49 FATSI-negative tumor specimens. FATSI screening showed that a substantial number of patients' tumors have FA functional deficiency, which led to germline alterations in several patients' tumors. Veliparib alone or with MMC was safely administered to these patients and produced clinical benefit in some. However, a better understanding of resistance mechanisms in this setting is needed.
Abstract 2581: Intervention of chronically-induced human breast cell carcinogenesis.
Authors: Shambhunath Choudhary, Shilpa Sood, Hwa-Chain Robert Wang
Journal: Cancer Research (2013)

Abstract The purpose of our study was to investigate the ability of dipyridamole (DPM) [2,6-bis(diethanolamino)-4,8-dipiperidinopyrimido-(5,4-d)-pyrimidine] to intervene in breast cell carcinogenesis induced by chronic exposure to environmental carcinogens. More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens through a multistep and multiyear disease process. Therefore, it is urgent to identify preventive agents effective in intervention of cellular carcinogenesis. DPM, an antioxidant and a synthetic inhibitor of phosphodiesterase, is approved by the Food and Drug Administration to inhibit platelet aggregation and vasoconstriction. DPM is also able to enhance the cytotoxicity of anticancer agents, such as cisplatin, adriamycin, and 5-fluorouracil, in various cell types. However, its ability to block breast cell carcinogenesis has not been determined. Using our chronically-induced breast cell carcinogenesis model as a target system, we found that DPM, at a non-cytotoxic physiologically-achievable dose of 10 nmol/L, effectively blocked breast cell carcinogenesis induced by chronic exposure to three unrelated carcinogens: 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP), benzo[a]pyrene (B[a]P), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The ability of DPM to block H-Ras upregulation, thus blocking ERK pathway activation, reactive oxygen species (ROS) elevation, and DNA damage in each exposure, may account for its mechanisms in intervention of carcinogenesis induced by chronic exposures to PhIP. Likewise, DPM's ability to block ROS elevation and DNA damage may account for its mechanisms in intervention of carcinogenesis chronically induced by NNK and B[a]P, as well. Our study revealed, for the first time, the novel ability of DPM to block breast cell carcinogenesis induced by three unrelated carcinogens. DPM should be seriously considered as a chemopreventive agent in development of strategies for reducing the risk of sporadic breast cancer associated with long-term exposure to environmental carcinogens. Citation Format: Shambhunath Choudhary, Shilpa Sood, Hwa-Chain Robert Wang. Intervention of chronically-induced human breast cell carcinogenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2581. doi:10.1158/1538-7445.AM2013-2581
Diuresis Makes Vesicocolic Fistula Visible on FDG PET/CT
Authors: Pan-Fu Kao, Jui-Hung Weng, Hsien-Chun Tseng, Jong-Kang Lee
Journal: Clinical Nuclear Medicine (2010)

A 71-year-old man with rectal cancer history was referred for FDG PET/CT due to serum carcinoembryonic antigen level elevation. In addition to rectal cancer recurrent lesion, the FDG PET/CT scan also showed homogeneous intense FDG accumulation in the whole segment of descending colon and a small air bubble in the urinary bladder. After furosemide injection, the vesicocolic fistula was confirmed by typical air pattern in the urinary bladder on attenuation CT images and the decrease FDG activity in the descending colon. The patient has had the clinical manifestations of pneumaturia and watery diarrhea which support the diagnosis of vesicocolic fistula.
P388 NK AND NKT CELLS EXPRESSING CD161 – A C-TYPE LECTIN CONFERRING REGULATORY PROPERTIES – ARE MARKEDLY REDUCED IN AUTOIMMUNE HEPATITIS
Authors: J.Z.H. Neo, X. Huang, E. Xystrakis, M.S. Longhi, W. Jassem, G. Mieli-Vergani, D. Vergani, Y. Ma
Journal: Journal of Hepatology (2014)
AB0289 The Degree of Discordance between Global Estimates by Patients and their Physicians in Various Rheumatic Diseases: Table 1.
Authors: S. Celik, I. Castrejon
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> In rheumatic diseases, quantitative assessment including estimates of global status by physicians (DOCGL) and patients (PATGL) is required since there is no any single gold standard biomarker measure for optimal management of the diseases and ideally, these estimates should be concordant. <h3>Objectives</h3> To examine the degree of discordance between DOCGL and PATGL and variables contributing to discordance in rheumatic diseases <h3>Methods</h3> A PubMed search was conducted with the restrictions of "Human" and "English" up to February 2013. Randomized Controlled Trials (RCTs), Cohort Studies, reviews and Meta-analysis were included. The studies including patients with rheumatic diseases comparing DOCGL vs PATGL were selected. The primary outcome was the percentage of concordance/discordance of PATGL and DOCGL. Two reviewers screened title/abstracts independently and collected data <h3>Results</h3> From 355 initial studies captured, 321 were excluded after reading title/abstract. 34 were selected for further review and finally 3 studies with rheumatoid arthritis (RA), 3 studies with systemic lupus erythematosus (SLE) and 1 study with juvenile idiopathic arthritis (JIA) were included. The cut-points for the discordance were variable between the studies (from 1 to 3). While the range of concordance between patients and physicians was 28.7 to 78%, PATGL&gt;DOCGL was 2 to 43.7% and DOCGL&gt;PATGL was 5 to 51.3%. In general, while the variables contributing to discordance for PATGL&gt;DOCGL were poor function, high age, pain, morning stiffness and poor mental health, the explanatory variables for the DOCGL&gt;PATGL were abnormal laboratories and high swollen, tender joint counts (Table 1). <h3>Conclusions</h3> The concordance rates between the patients and physicians on global estimates in many rheumatic diseases were low. Discordance has been reported to be associated with poorer outcomes. To record both the patient and physician global estimates at each visit can play an important role to improve the concordance between them. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6040
Abstract 3860: Differential gene expression and HPV in penile carcinoma
Authors: Marilia de Freitas Calmon, Erica Babeto, Mânlio Tasso Oliveira Mota, Natália Maria Candido, Ana Paula Girol, Sônia Maria Oliani, Jane Lopes Bonilha, José Vassallo, Paula Rahal
Journal: Cancer Research (2011)

Abstract Penile cancer (PC) is an invasive epithelium tumor, representing more than 10% of the malignancies in men in some developing countries, mainly in Brazil. Studies on the aetiopathogenesis of this cancer have focused on its association with the HPV. Patients with PC without treatment usually die within 2 years after diagnosis, because of uncontrollable loco regional disease or from distant metastasis. The aim of this study is evaluating the possible role of HPV in the development of PC and the use of the RaSH technique to analyze gene expression in normal tissues and penile tumors. HPV detection was done by PCR with generic primers GP5+/GP6+ and HPV typing was done by direct sequencing. RaSH methodology identified differentially expressed genes, generating subtractive cDNA libraries. The presence of HPV was analyzed in 58 samples of patients with PC. It has been observed high prevalence (85.12%) of HPV. Of the 16 samples sequenced, HPV-16 was found in 14 (87.5%) samples, HPV-11 in 1 (6.3%) and HPV-35 in 1 (6.3%). The RaSH subtractive libraries identified the presence of 57 clones differentially expressed between samples, 30 in tumor samples and 27 in the normal tissue. The genes PBEF1, ANXA1, RPL6 and KIAA1033 were overexpressed in the tumors. On the other hand, the gene p16 was overexpressed in the normal tissue. Finally, the expression of the selected genes was confirmed by qPCR. Only ANXA1 was validated with overexpression in 80% of all samples. It was also analyzed ANXA1 protein expression by immunohistochemistry in 25 samples of penile cancer. It was observed overexpression of ANXA1 protein 100% of PC samples compared to normal tissue. The results obtained are capable of revealing differences in patterns of gene expression between normal and tumor tissues. Moreover, it was observed high prevalence of HPV, suggesting an important role of this virus in penile carcinogenesis. Besides, overexpression of ANXA1 was observed in most of the penile cancer samples and such information will contribute to develop a possible marker for penis tumor diagnostic and prognostic, improving the development of directed therapies against this new putative marker. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3860. doi:10.1158/1538-7445.AM2011-3860
Bronchodilators and Corticosteroids in the Treatment of Obstructive Pulmonary Emphysema
Authors: William Franklin, A. L. Michelson, F. C. Lowell, I. W. Schiller
Journal: New England Journal of Medicine (1958)

OBSTRUCTIVE pulmonary emphysema, as the term is used here, refers to a chronic progressive process manifested clinically by dyspnea, which most commonly makes its appearance in middle-aged or elderly males who have had no previous localized or diffuse chronic pulmonary disease and which has generally been regarded as of unknown etiology. In its advanced form, it has striking airway obstruction readily recognizable by a reduction in the maximal expiratory flow rate as the outstanding characteristic. A second common but not invariably prominent feature of the disease is chronic cough, often developing a number of years before the onset of obstructive . . .