The Postantibiotic Effect
Authors: WILLIAM A. CRAIG
Journal: Annals of Internal Medicine (1987)

Editorials1 June 1987The Postantibiotic EffectWILLIAM A. CRAIG, M.D., BENNETT VOGELMAN, M.D.WILLIAM A. CRAIG, M.D., BENNETT VOGELMAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-6-900 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSuppression of bacterial growth that persists after short exposure of organisms to antimicrobial agents has been seen since early investigations with penicillin. For example, Parker and Luse (1) showed in 1948 that staphylococci exposed to penicillin G for 20 minutes and then transferred to drug-free broth did not resume normal growth for 1 to 3 hours. These findings were applied to studies with antituberculous drugs (2), but not until the past decade were they extended to antimicrobial drugs developed after penicillin and to gram-negative bacilli (3, 4). The termpostantibiotic effecthas been used to describe this phenomenon because it...References1. PARKERLUSE RS. The action of penicillin on staphylococcus: further observations on the effect of a short exposure. J Bacteriol. 1948;56:75-81. CrossrefMedlineGoogle Scholar2. BEGGSJENNE WJ. Isoniazid uptake and growth inhibition of Mycobacterium tuberculosis in relation to time and concentration of pulsed drug exposures. Tubercle. 1969;50:377-85. CrossrefMedlineGoogle Scholar3. MCDONALDCRAIGKUNIN PWC. Persistent effect of antibiotics on Staphylococcus aureus after exposure for limited periods of time. J Infect Dis. 1977;135:217-23. CrossrefMedlineGoogle Scholar4. BUNDTZENGERBERCOHNCRAIG RADW. Postantibiotic suppression of bacterial growth. Rev Infect Dis. 1981;3:28-37. CrossrefMedlineGoogle Scholar5. CRAIGGUDMUNDSSON WS. The postantibiotic effect. In: LORIAN V, ed. Antibiotics in Laboratory Medicine. 2nd ed. Baltimore: William & Wilkins; 1986:515-36. Google Scholar6. TÄUBERZAKSHELDHENGSTLERSANDE MOWBM. The postantibiotic effect in the treatment of experimental meningitis caused by Streptococcus pneumoniae in rabbits. J Infect Dis. 1984;149:575-83. CrossrefMedlineGoogle Scholar7. INGERMANPITSAKISROSENBERGLEVISON MPAM. The importance of pharmacodynamics in determining the dosing interval in therapy for experimental pseudomonas endocarditis in the rat. J Infect Dis. 1986;153:707-14. CrossrefMedlineGoogle Scholar8. KAPUSNIKGORDINSCOTTHACKBARTHSANDE JFKCM. Efficacy of once daily versus conventional aminoglycoside therapy for experimental pseudomonas pneumonia [Abstract]. Clin Res. 1985;33:57A. Google Scholar9. VOGELMANCRAIG BW. Postantibiotic effects. J Antimicrob Chemother. 1985;15(suppl A):37-46. CrossrefMedlineGoogle Scholar10. GUDMUNDSSONVOGELMANCRAIG SBW. The in vivo postantibiotic effect of imipenem and other new antimicrobials. J Antimicrob Chemother. 1986;18(suppl E):67-73. CrossrefMedlineGoogle Scholar11. CRAIGMATTIE WH. Postantibiotic effect (PAE) with Bacteroides fragilis[Abstract]. In: Program and Abstracts of the 26th Interscience Conference on Antimicrobial Agents and Chemotherapy. New Orleans: American Society for Microbiology; 1986:122. Google Scholar12. MCDONALDWETHERALLPRUUL PBH. Postantibiotic leukocyte enhancement: increased susceptibility of bacteria pretreated with antibiotics to activity of leukocytes. Rev Infect Dis. 1981;3:38-44. CrossrefMedlineGoogle Scholar13. TUOMANEN E. Newly made enzymes determine ongoing cell wall synthesis and the antibacterial effects of cell wall synthesis inhibitors. J Bacteriol. 1986;167:535-43. CrossrefMedlineGoogle Scholar14. VOGELMANCRAIG BW. Kinetics of antimicrobial activity. J Pediatr. 1986;108(5 pt 2):835-40. CrossrefMedlineGoogle Scholar15. GERBERCRAIGBRUGGERFELLERVASTOLABRANDEL AWHCAJ. Impact of dosing intervals on activity of gentamicin and ticarcillin against Pseudomonas aeruginosain granulocytopenic mice. J Infect Dis. 1983;147:910-7. CrossrefMedlineGoogle Scholar16. POWELLTHOMPSONLUTHE SWM. Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin. J Infect Dis. 1983;147:918-32. CrossrefMedlineGoogle Scholar17. FELDVALDIVIESOBODEYRODRIGUEZ RMGV. A comparative trial of sisomicin therapy by intermittent versus continuous infusion. Am J Med Sci. 1977;274:179-88. CrossrefMedlineGoogle Scholar18. NORDSTROMCRONBERGRINBERGTRENSTROMWALDER LSHOM. Prospective, comparative, randomized clinical study of aminoglycosides given once a day versus three times a day in severe infections. In: ISHIGAMI J, ed. Recent Advances in Chemotherapy. Tokyo: University of Tokyo Press; 1985:2653-4. Google Scholar19. ROOSENDAALBAKKER-WOUDENBERGVAN DEN BERGMICHEL RIJM. Therapeutic efficacy of continuous versus intermittent administration of ceftazidime in an experimental Klebsiella pneumoniae pneumonia in rats. J Infect Dis. 1985;152:373-8. CrossrefMedlineGoogle Scholar20. BODEYKETCHELRODRIGUEZ GSV. A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients. Am J Med. 1979;67:608-16. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: William S. 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