PHENYLBUTAZONE TOXICITY: REPORT OF A CASE OF ACUTE RENAL FAILURE
Authors: M B LIPSETT, R GOLDMAN
Journal: Annals of Internal Medicine (1954)

Case Reports1 November 1954PHENYLBUTAZONE TOXICITY: REPORT OF A CASE OF ACUTE RENAL FAILUREMORTIMER B. LIPSETT, M.D., RALPH GOLDMAN, M.D.MORTIMER B. LIPSETT, M.D.Search for more papers by this author, RALPH GOLDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-5-1075 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA hitherto unreported reaction to phenylbutazone will be presented in this report. The diagnosis of acute renal failure is supported by the course of the illness and a renal biopsy.CASE REPORTThe patient was a 60 year old retired Army colonel who entered on September 24, 1953, complaining of inability to urinate for three days. He had been followed in the Arthritis Clinic of Wadsworth General Hospital for five years with diagnosis of mild rheumatoid and degenerative arthritis. During this period numerous blood counts, urinalyses and occasional serum creatinine and blood urea nitrogen determinations had been normal. He had...Bibliography1. Kolff WJ: Forced high caloric, low protein diet and the treatment of uremia, Am. J. Med. 12: 667, 1952. CrossrefMedlineGoogle Scholar2. MurphyKuzmaPolleyGrill FDJFTZJ: Clinicopathologic studies of renal damage due to sulfonamide compounds, Arch. Int. Med. 73: 433, 1943. CrossrefGoogle Scholar3. OliverMacDowellTracy JMA: The pathogenesis of acute renal failure associated with traumatic and toxic injury. Renal ischemia, nephrotoxic damage and the ischemuric episode, J. Clin. Investigation 30: 1305, 1951. CrossrefGoogle Scholar4. HemmingKuzell AWC: The pharmacologic and clinical characteristics of phenylbutazone (Butazolidin), Antibiotics and Chemotherapy 3: 634, 1953. Google Scholar5. WilkinsonBrown ELH: The effect of Butazolidin (phenylbutazone) on water and electrolyte excretion, Am. J. M. Sc. 225: 153, 1953. CrossrefMedlineGoogle Scholar6. PattersonBensonSchoenberg RMJFPL: Clinical evaluation of Butazolidin in 32 cases of rheumatoid arthritis, U. S. Armed Forces M. J. 4: 109, 1953. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Received for publication December 22, 1953.From the Veterans Administration Center, Los Angeles, California, and the Department of Medicine, University of California Medical Center, Los Angeles, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe nephrotoxicity of analgesics4-Butyl-1,2-Diphenyl-3,5-Dioxo-Pyrazolidine 50-33-9Non-steroidal anti-inflammatory drugsNonsteroidal anti-inflammatory drugs: Effects on kidney functionNon-steroidal anti-inflammatory drugs and acute renal disease: A case control studyCurrent status of nephrotoxicity caused by non-steroidal anti-inflammatory drugsNonsteroidal Anti-Inflammatory Drugs: Effects on Kidney FunctionDifferential inhibitory potencies of non-steroidal antiinflammatory drugs on smooth muscle prostanoid synthesisAnalgesic Nephropathy and the Effect of Non-Steroidal Anti-Inflammatory Drugs on the KidneyDrug-Induced Parenchymal Renal Disease in OutpatientsArachidonic acid metabolism in renal diseaseNephrotoxic Tubular and Interstitial Lesions: Morphology and ClassificationReversible Non-oliguric Impairment of Renal Function during Azapropazone TreatmentEffects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal functionRenal Syndromes Associated with Nonsteroidal Antiinflammatory DrugsPhenylbutazone nephrotoxicity — A light and electron microscopic studyPharmacological Aspects of Renal Failure and DialysisCase Report Acute Tubular Necrosis Following High-Dose Cefamandole Therapy for Hemophilus parainfluenzae EndocarditisSTRUCTURE SIDE-EFFECT SORTING OF DRUGS.The Kidney Function in Relation to Drug Consumption in Patients with Rheumatoid Arthritis. (V)Pharmacologic Aspects of Regular Dialysis TreatmentRenal Papillary Necrosis Associated with Indomethacin and Phenylbutazone Treated Rheumatoid ArthritisAssociation of renal papillary necrosis and ankylosing spondylitisFurther studies of the acute effects of phenylbutazone, oxyphenbutazone and indomethacin on the rat kidneyDrug-induced renal diseasesRenal and gastric lesions after phenylbutazone and indomethacin in the ratRECURRENT ACUTE RENAL FAILURE INDUCED BY PHENAZONE HYPERSENSITIVITYREFERENCESAkutes NierenversagenIrgapyrin toxicityThrombotic thrombocytopenic purpura with acute anuric renal failureToxic nephropathyThe Kidney Function in Relation to Drug Consumption in Patients with Rheumatoid Arthritis. (V)Acute Renal Failure Caused by PhenylbutazoneInvestigation of the Kidney Function in Rheumatoid Arthritis: IRHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TWELFTH RHEUMATISM REVIEW)* Part IICHARLEY J. SMYTH, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., HOWARD F. POLLEY, MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P.A Case of Poisoning with 10 Grams of ButazolidinAntipyretische AnalgetikaAntipyretische AnalgetikaThe Toxic Effects of Phenylbutazone (Butazolidin) 1 November 1954Volume 41, Issue 5Page: 1075-1079KeywordsAcute renal failureBiopsyBlood countsBlood urea nitrogenCreatinineHospitalsOsteoarthritisRheumatoid arthritisToxicityUrination ePublished: 1 December 2008 Issue Published: 1 November 1954 PDF downloadLoading ...