tbuckley/cabot-search huggingface dataset:
The frequency of falls in patients with advanced cancer followed in an outpatient palliative care center.
Authors: Maxine De la Cruz, Neha Didwaniya, Kimberson Tanco, SeongHoon Shin, Akhila Sunkepally Reddy, Maria Teresa San Miguel Arregui, Herlinda Moreno, Eduardo Bruera, Gary B. Chisholm, Janet L. Williams
Journal: Journal of Clinical Oncology (2013)

225 Background: Falls are a concern in patients who are frail, have advance age or severe underlying medical condition as a significant cause of morbidity and reduced quality of life. It has been reported to occur in up to 50% of palliative care patients in different settings. Our aim was to determine the frequency of falls and identify its predictors and correlates in patients with advanced cancer. Methods: We reviewed 1,984 consecutive patients with advanced cancer seen in the outpatient supportive care center and determined the frequency of patient reported falls within the last month prior to the visit. Baseline patient characteristics, symptom severity scores in the Edmonton Symptom Assessment Scale (ESAS), medication use, functional status, and use of assistive devices were used to identify factors that are predictive of falls using backwards stepwise logistic regression. Results: 1,041 (52%) were female, 1,377 (69%) were non-Hispanic-white, 343 (17%) had peripheral neuropathy, 237 (12%) were on psychotropic medications, and 1,140 (58%) were on opioids. There were 211 (11%) patient reported falls. Presence of brain metastasis, use of assistive device, ECOG, ESAS depression, and weight prior to visit were significantly associated with patient reported falls in the multivariate model. Conclusions: One tenth of patients seen in the outpatient supportive care clinic reported falls. Our findings showing that falls to be associated with brain metastasis, assistive device, functional status, ESAS depression and weight are useful in stratifying high risk patients. They also show that certain medications deemed as risk factors in other populations were not associated with falls. [Table: see text]
Abstract 12096: Temporal Trends in Ischemic Stroke and Anticoagulation Therapy Among Medicare Beneficiaries Having Non-Valvular Atrial Fibrillation With and Without Diabetes Mellitus, 1992-2010
Authors: Gautam R Shroff, Craig A Solid, Charles A Herzog
Journal: Circulation (2014)

Background: Patients with diabetes mellitus (DM) and non valvular atrial fibrillation (AF) are at increased risk of ischemic stroke; but evidence regarding ischemic stroke and warfarin use in the literature is limited. We evaluated temporal trends in ischemic stroke and warfarin use among the US Medicare population with and without DM. Methods: One-year cohorts of patients with Medicare as primary payer, 1992-2010, were created using the Medicare 5% sample. ICD-9-CM codes were used to identify AF, ischemic and hemorrhagic stroke and comorbidities; ≤3 consecutive prothrombin-time claims were used to identify warfarin use. Results: Demographic characteristics between 1992 (n=40255) and 2010 (n=80314) respectively were (proportions): age 65-74 years (37%, 32%); age ≤ 85 years (20%, 25%); white (94%, 93%); hypertension (46%, 80%); DM (20%, 32%), chronic kidney disease (5%, 18%). Ischemic stroke rates among Medicare AF patients with DM decreased by 71% (1992, 2010) from 65 to 19 /1000 patient-years; warfarin utilization increased from 28% to 62% respectively (Figure 1A). Among Medicare AF patients without DM, ischemic stroke rates decreased by 68% from 44 to 14/ 1000 patient-years; warfarin use increased 26% to 59% respectively (Figure 1B). About 38% Medicare AF pts with DM did not receive anticoagulation in 2010. Conclusion: Medicare patients with and without DM had a similar reduction in ischemic stroke rates; and similar increase in warfarin utilization over the study period. A significant proportion of Medicare pts with DM did not receive anticoagulation with warfarin for AF in 2010; this population deserves future attention.
Genetic Polymorphism in MDR-1: A Tool for Examining Allelic Expression in Normal Cells, Unselected and Drug-Selected Cell Lines, and Human Tumors
Authors: Lyn A. Mickley, Jong-Seok Lee, Zheng Weng, Zhirong Zhan, Manuel Alvarez, Wyndham Wilson, Susan E. Bates, Tito Fojo
Journal: Blood (1998)
Genotype MTBDR (Hain) test in suspected MDR-TB patients
Authors: Piamlarp Sangsayunh, Krisana Cheewakul, Chareon Chuchothawon
Journal: European Respiratory Journal (2013)

Introduction: Diagnosis of MDR-TB in Thailand was delayed because of insufficient investigation. Hain Test was a new easy and rapid technology.Aims: To evaluate accuracy of Hain test compared with conventional culture. To evaluate the judgment of chest physician for starting treatment.Method: Diagnostic and observational study, 100 previous TB treatment and suspected MDR-TB patients who attended Central Chest institute were inclusion between Sep- Dec 2012. They were assessed direct smear test, conventional culture and DST.Physician judgments of MDR-TB treatments were observed. Results: 53 patients of failure, 23 of relapse, 24 of default were inclusion.Periods of time from first diagnosis of TB until suspected MDR-TB were 4-240 months. 65%, 31 %, 4 % samples of Hain test were M.TB positive, negative, and MOTT positive. DST of Hain test showed 46 % were IR resistance,10 %INH and 3%RF resistance alone. Sensitivity, specificity, PPV, NPVof MDR-TB Hain test were 85%,79%,46%,96%.7 had positive MOTT(M. abscessus) in conventional culture and only 1 patients has positive Hain test together.Sensitivity, specificity, PPV, NPV for MOTT diagnosis of Hain test were 14%, 96%, 25%, 92%.The 63 % chest physicians judged to treat following Hain test. There was correlation between judgments of starting MDR-TB treatment and IR resistance Hain test report (p=0.03). No correlation between judgments and pattern of previous TB treatment(p=0.16), and periods of time from first to suspected MDR-TB (p= 0.18) were demonstrated.Conclusion: We recommended using Hain test in diagnosis of MDR-TB in highly suspected case and waiting for conventional culture in MOTT.Most physicians decided to start MDR-TB regimens after receive IR resistance Hain test report.
Can mpMRI predict biochemical recurrence after radical prostatectomy? Implications for preoperative staging and surgical planning.
Authors: Richard Ho, Arvin Koruthu George, Thomas P Frye, Steven Abboud, Raju Chelluri, Michele Fascelli, Nabeel Ahmad Shakir, Annerleim Walton-Diaz, Sandeep Sankineni, Maria J Merino, Baris Turkbey, Peter L. Choyke, Peter A. Pinto
Journal: Journal of Clinical Oncology (2015)

161 Background: Multiparametric magnetic resonance imaging (mpMRI) used in conjunction with MR/TRUS fusion-guided biopsy has improved detection and localization of clinically significant prostate cancer. We aim to evaluate the utility of preoperative MRI characteristics to predict biochemical recurrence (BCR) following radical prostatectomy. Methods: Patients who underwent robotic assisted radical prostatectomy (RARP) between 2007-2014 at the National Institutes of Health were reviewed. We identified patients with BCR defined following the guidelines of the AUA Localized Prostate Cancer Update Panel report (serum PSA ≥0.2 ng/ml with a subsequent confirmatory value). Bivariate analysis and logistic regression were used to determine the association of mpMRI and preoperative patient characteristics with BCR. Results: Of 365 patients who had RARP, 21 met criteria for BCR with a median follow up of 19 months (IQR: 10-34). Mean preoperative PSA (ng/mL) [p&lt;0.001], high MRI suspicion level [p=0.016], presence of extracapsular extension (ECE) on MRI [p=0.003], and total prostate volume by MRI (cc) [p&lt;0.001] were associated with BCR. Increasing MRI suspicion corresponded to increases in rates of BCR within suspicion levels (2.22% of low, 3.88% of moderate, and 10.64% of high). The rates of BCR were significantly greater in men with ECE on final pathology [p&lt;0.001]. Gleason grade trended toward significance [p=0.058]. Controlling for potentially confounding preoperative variables on multivariate analysis, MRI suspicion score, ECE on MRI, and total prostate volume by MRI remained significantly associated with predicting BCR. Conclusions: MRI suspicion score, ECE on mpMRI, and total prostate volume were associated with BCR in patients undergoing RARP. Preoperative mpMRI characteristics aid in risk stratification, patient counseling, and modification of surgical technique in those with high risk imaging features for BCR. The integration of mpMRI characteristics into a comprehensive model of BCR may provide robust tools for preoperative staging and surgical planning.
Internet-Delivered Disease Management for Recurrent Depression: A Multicenter Randomized Controlled Trial
Authors: Hans Kordy, Markus Wolf, Kai Aulich, Martin Bürgy, Ulrich Hegerl, Johannes Hüsing, Bernd Puschner, Christine Rummel-Kluge, Helmut Vedder, Matthias Backenstrass
Journal: Psychotherapy and Psychosomatics (2016)

Strategies to improve the life of patients suffering from recurrent major depression have a high relevance. This study examined the efficacy of 2 Internet-delivered augmentation strategies that aim to prolong symptom-free intervals.Efficacy was tested in a 3-arm, multicenter, open-label, evaluator-blind, randomized controlled trial. Upon discharge from inpatient mental health care, 232 adults with 3 or more major depressive episodes were randomized to 1 of 2 intervention groups (SUMMIT or SUMMIT-PERSON) or to treatment as usual (TAU) alone. Over 12 months, participants in both intervention arms received, in addition to TAU, intense monitoring via e-mail or a smartphone, including signaling of upcoming crises, assistance with personal crisis management, and facilitation of early intervention. SUMMIT-PERSON additionally offered regular expert chats. The primary outcome was 'well weeks', i.e. weeks with at most mild symptoms assessed by the Longitudinal Interval Follow-Up Evaluation, during 24 months after the index treatment.SUMMIT compared to TAU reduced the time with an unwell status (OR 0.48; 95% CI 0.23-0.98) through faster transitions from unwell to well (OR 1.44; 95% CI 0.83-2.50) and slower transitions from well to unwell (OR 0.69; 95% CI 0.44-1.09). Contrary to the hypothesis, SUMMIT-PERSON was not superior to either SUMMIT (OR 0.77; 95% CI 0.38-1.56) or TAU (OR 0.62; 95% CI 0.31-1.24). The efficacy of SUMMIT was strongest 8 months after the intervention.The fully automated Internet-delivered augmentation strategy SUMMIT has the potential to improve TAU by reducing the lifelong burden of patients with recurrent depression. The fact that the effects wear off suggests a time-unlimited extension.
An alternate method to overcoming central venous catheter blockage in patients receiving high-dose fluorouracil and leucovorin.
Authors: J L Marshall, R J DeLap
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.7.1433 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8315442 An alternate method to overcoming central venous catheter blockage in patients receiving high-dose fluorouracil and leucovorin. J L MarshallxJ L MarshallSearch for articles by this author , R J DeLapxR J DeLapSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.7.1433 PDF "An alternate method to overcoming central venous catheter blockage in patients receiving high-dose fluorouracil and leucovorin.." Journal of Clinical Oncology, 11(7), pp. 1433–1434© 1993 by American Society of Clinical Oncology
Long-term quality of life and psychological response after flap reconstructive surgery and radiotherapy in head and neck cancer patients
Authors: M. Garzaro, M. Airoldi, L. Raimondo, G. Pecorari, C. Giordano, P. Caldera, A. Varetto, C. Zanon, R. Torta
Journal: Journal of Clinical Oncology (2008)

20553 Background: Head and neck tumors and their treatment may negatively affect the patient's quality of life (QoL). The aim of this study is the evaluation of the impact of flap reconstructive surgery followed by radiation therapy (RT) on QoL and psychological functioning of patients with oral and oropharyngeal tumors. Methods: The population was composed by 36 patients affected by advanced tumors, who underwent demolitive and reconstructive surgery, followed by RT (Median dose 61.03 ± 4.74 Gy) In order to evaluate the late effects of RT we used the RTOG - EORTC late radiation morbidity score plus the DISCHE morbidity recording scheme. Psycho-oncological assessment included: Hospital Anxiety and Depression Scale, Montgomery Asberg Depression Rating Scale, Mini Mental Adjustment to Cancer Scale, Temperament and Character Inventory, Goodenough_Harris "Draw a person Test", EORTC QoL HN 35. Results: The most frequent and severe late toxicities were: salivary glands disfunction (63 %), subcutaneous fibrosis (72 %), dysphagia (53 %) and dysphonia (42 %). Low levels of anxiety and depression were observed; the profile underscores the prevalence of active coping styles (fighting spirit, etc.). Patients with severe dysphagia (Dische 3–4) showed statistically significant (p<0.05) higher levels of depression and anxiety: dysphagia influences the perceived global health (GH) and QoL, with effects on fatigue, physical, social and relational functioning. Taste impairment was associated to lower perceived GH and QoL, with higher scores of depression. Dryness of mouth determines impairment in some aspects of QoL, such as social eating and contact, although without effects on emotional scores and perceived GH and QoL. The analysis of the DAP test shows severe troubles in auto-perceived body-image in 33% of the sample. Conclusions: Radical surgery followed by flap reconstruction and postoperative RT could result in a heavy addictive effect, strongly affecting nutrition and speech. Anxious and depressive traits seems to be underestimated by auto-report instruments. However, late side effects of treatments, such as dysphagia, are clearly associated to impairment in perceived QoL and global health, and to a higher risk of psychological complains. No significant financial relationships to disclose.
The Relative Efficacy and Safety of Clopidogrel in Women and Men
Authors: Jeffrey S. Berger, Deepak L. Bhatt, Christopher P. Cannon, Zhengming Chen, Lixin Jiang, James B. Jones, Shamir R. Mehta, Marc S. Sabatine, Steven R. Steinhubl, Eric J. Topol, Peter B. Berger
Journal: Journal of the American College of Cardiology (2009)
Antitumor activity of patient-derived renal cell carcinoma cells fused with allogeneic dendritic cells: In vitro results and clinical responses
Authors: J. Xia, J. Zhou
Journal: Journal of Clinical Oncology (2009)

3056 Background: Renal cell carcinoma (RCC) has been shown to be highly susceptible to immune-based treatment strategies. Methods: In the present study, patient-derived tumor cells were fused with allogeneic dendritic cells (DC) to elicit antitumor activity against RCC. DC from HLA-A2+ healthy donors were fused with primary RCC cells from 10 patients. Phenotype of fusion cells was characterized by flow cytometer and confocal microscopy. In vitro, T-cell proliferation, IFN-γ secretion, and cytotocic T lymphocytes (CTL) activity elicited by allogeneic DC/RCC fusion cells were assessed. Clinically, 10 patients were vaccinated with allogeneic DC/RCC fusion vaccine. The adverse effects and toxicity were observed. The clinical response was evaluated by CT scans. Results: After fusion, the created hybrids expressed both tumor-associated antigen and DC-derived molecules and could stimulate the proliferation and IFN-γ secretion of T-cells as well as elicit strong CTL activity against RCC cells in vitro. In vivo, neither serious adverse effects nor signs of autoimmune disease were observed after vaccination therapy. Percentage of T lymphocyte subsets in peripheral blood of patients was increased significantly. One of 10 patients exhibited a partial response with regression of lung metastases. Six patients showed stable disease with stabilization of previously progressive disease (follow-up 1.5 year). Conclusions: The data suggest that allogeneic DC/RCC fusion vaccine is safe and can elicit immunological responses in patients with RCC. No significant financial relationships to disclose.
Massachusetts Medical Society
Authors: Marion McKee, Robert J. Haggerty
Journal: New England Journal of Medicine (1957)

TOXIC HAZARDS*Aminophylline Poisoning†Aminophylline is a very useful drug in the treatment of bronchial and cardiac asthma, both in children and in adults. Toxic symptoms are seen in children as a result of both accidental ingestion and excessive therapeutic doses. They are more frequent in pediatrics because the preparations available today contain considerably more aminophylline than the amount recommended for infants and small children. The following fatal case from the Children's Medical Center, Boston, is an example of a therapeutic overdose:D. B., a 3-year-old boy with recurrent attacks of asthma, was admitted to the hospital because of vomiting . . .
간세포암종 환자의 예후 예측에 있어 양전자방출단층촬영(PET)의 유용성
Authors: 공윤호 ( Yun Ho Kong ), 한철주 ( Chul Ju Han ), 이상대 ( Sang Dae Lee ), 손위식 ( Wee Sik Sohn ), 김민재 ( Min Jae Kim ), 기승석 ( Seung Seog Ki ), 김진 ( Jin Kim ), 정숙향 ( Sook Hyang Jeong ), 김유철 ( You Cheoul Kim ), 이진오 ( Jhin Oh Lee ), 천기정 ( Gi Jeong Cheon ), 최창운
Journal: Clinical and Molecular Hepatology (2004)

목적: 간세포암종은 FDG-PET 영상에서 다양한 수준의 FDG 축적을 보인다. 이는 간세포암종의 포도당 대사 활성이 다양함을 의미하는데, 이러한 차이가 환자의 예후와 연관이 있는지를 알아보고자 하였다. 대상과 방법: 27예의 간세포암종 환자들을 대상으로 각각의 환자에서 FDG-PET 영상을 얻어 FDG 축적의 정도(SUV 및 SUV비)를 조사하였고 이들 변수들이 생존율에 영향을 줄 수 있는 인자인지를 확인하기 위해 Cox proportional haz
Development of a mathematical model of intraperitoneal/intravenous infusion of carboplatin. A Sankai Gynecology Study Group study
Authors: Y. Miyagi, K. Fujiwara, J. Kigawa, H. Itamochi, S. Nagao, E. Aotani, N. Terakawa, I. Kohno
Journal: Journal of Clinical Oncology (2004)

2037 Background: For ovarian cancer patients, it remains unclear whether carboplatin should be administered intraperitoneally (IP) or intravenously (IV). Because it is virtually impossible to measure the actual tissue concentration in peripheral organs, we have developed a three-compartment mathematical model for both IP and IV administration to estimate the pharmacological information in the serum (S), [the] peritoneal cavity (CV), and [the] peripheral space (PRH) Methods: Twenty two patients with ovarian cancer were enrolled in this study; two groups of 11 patients each received carboplatin IP or IV, respectively. Carboplatin (AUC 6) was diluted in 500 ml 5% glucose and administered either as an IP bolus infusion or IV drip infusion in 1 hr. Patients receiving IV injections also received an infusion of 500 ml 5% glucose to enable us to obtain intraperitoneal samples. IP fluid and blood samples were obtained, immediately, 1, 2, 4, 8, 12 and 24 hrs after administration. The free platinum was measured by atomic absorption. A model with simultaneous differential equations was created and solved by the Runge-Kutta method to fit the sample data by the least square method. Results: The rate constants of platinum for CV to S, S to CV, S to PRH, PRH to S, and elimination were 0.94±0.8 (mean±SD), 1.28±2.5, 16.50±9.3, 0.99±0.7, 4.14±1.5 (/hr), respectively. By calculation, the maximum dose and the total amount of free platinum in PRH by the IP/IV route, were 134.4±59.5/298.9±62.4 mg and 71053.7±39590.7/112678.2±46486.1 mg*min, respectively. The AUC value in S was identical in both routes. However, the AUC value in CV was 3.8 times higher than in S by the IP route, regardless of the dose, infusion time or body weight. Conclusions: A mathematical model of IP/IV administration was developed. The model can present the pharmacokinetics in not only S and CV but also in PRH. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aventis
Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina
Authors: Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Hironori Uzuka, Hongxin Wang, Ryuji Tsuburaya, Kiyotaka Hao, Kazuma Ohyama, Yuji Odaka, Satoshi Miyata, Kenta Ito, Hiroaki Shimokawa
Journal: Journal of the American College of Cardiology (2016)
Severe ileus from cisplatin and vinblastine infusion in neuroblastoma.
Authors: B Bostrom
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.8.1356 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3411345 Severe ileus from cisplatin and vinblastine infusion in neuroblastoma. B BostromxB BostromSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.8.1356 PDF "Severe ileus from cisplatin and vinblastine infusion in neuroblastoma.." Journal of Clinical Oncology, 6(8), p. 1356© 1988 by American Society of Clinical Oncology
Abstract 19119: Augmentation Index is Associated With Renal Function in Black but Not in White Young Adults: The Bogalusa Heart Study
Authors: Camilo Fernández Alonso, Wei Chen, Sathanur R Srinivasan, Gerald S Berenson
Journal: Circulation (2013)

Background: Increased Augmentation Index (AI) has been associated with kidney damage in patients with hypertension and underlying cardio-metabolic diseases. However, information is scant on the association between AI and renal function/performance in non-institutionalized asymptomatic young adults. Hypothesis: Race-specific differences exist on the association between AI and renal function (as defined by estimated glomerular filtration rate (eGFR)), in asymptomatic young adults. Methods: As a part of the Bogalusa Heart Study, a long term community based study, 884 non-institutionalized participants with a mean age of 43.5 years (29.4-51.3), 68.3% whites and 41.9% male were considered. AI was estimated non-invasively by applanation tonometry of the radial artery. eGFR was calculated using the MDRD study equation. Race-specific independent association of AI with eGFR was tested through multivariable adjusted linear regression analyses. Results: Black participants had higher AI and eGFR levels compared to whites. Of note, black females had significantly higher levels of AI and eGFR compared to black males (p&lt;0.01). No significant sex differences were noted in white participants. In multivariable adjusted linear regression analyses, controlling for age, sex and traditional cardiovascular risk factors, AI was significantly and directly associated with eGFR in blacks (B=1.12, p&lt;0.001), but not in whites (B=0.039, p=0.34) Conclusion: The observed differences in the impact of AI on renal function help support the hypothesis that underlying mechanisms for cardiovascular disease related-end organ damage differ among race groups. Further, this may aid to enhance race-specific approaches on prevention and screening of cardiovascular disease and complications.