tbuckley/cabot-search huggingface dataset:
The Association of Skin Intrinsic Fluorescence With Type 1 Diabetes Complications in the DCCT/EDIC Study
Authors: Trevor J. Orchard, Timothy J. Lyons, Patricia A. Cleary, Barbara H. Braffett, John Maynard, Catherine Cowie, Rose A. Gubitosi-Klug, Jeff Way, Karen Anderson, Annette Barnie, Stephan Villavicencio
Journal: Diabetes Care (2013)

To determine whether skin intrinsic fluorescence (SIF) is associated with long-term complications of type 1 diabetes (T1D) and, if so, whether it is independent of chronic glycemic exposure and previous intensive therapy.We studied 1,185 (92%) of 1,289 active Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) participants from 2010 to 2011. SIF was determined using a fluorescence spectrometer and related cross-sectionally to recently determined measures of retinopathy (stereo fundus photography), cardiac autonomic neuropathy (CAN; R-R interval), confirmed clinical neuropathy, nephropathy (albumin excretion rate [AER]), and coronary artery calcification (CAC).Overall, moderately strong associations were seen with all complications, before adjustment for mean HbA1c over time, which rendered these associations nonsignificant with the exception of sustained AER>30 mg/24 h and CAC, which were largely unaffected by adjustment. However, when examined within the former DCCT treatment group, associations were generally weaker in the intensive group and nonsignificant after adjustment, while in the conventional group, associations remained significant for CAN, sustained AER>30 mg/24 h, and CAC even after mean HbA1c adjustment.SIF is associated with T1D complications in DCCT\EDIC. Much of this association appears to be related to historical glycemic exposure, particularly in the previously intensively treated participants, in whom adjustment for HbA1c eliminates statistical significance.
(19) Pigmented naevus of chest
Authors: J. A. Carruthers, P.F.D. Naylor
Journal: British Journal of Dermatology (1974)

Journal Article (19) Pigmented naevus of chest Get access J. A. Carruthers, J. A. Carruthers St Thomas' Hospital, London Search for other works by this author on: Oxford Academic Google Scholar P.F.D. Naylor P.F.D. Naylor St Thomas' Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue s10, 1 July 1974, Page 64, https://doi.org/10.1111/j.1365-2133.1974.tb12521.x Published: 01 July 1974
A Case of Strangulated Internal Hernia into the Foramen of Winslow
Authors: J. E. Square
Journal: BMJ (1886)

THE following case, I think, deserves publication, although its details are, of necessity, very imperfect.R. F., aged 25, a clerk, was apparently in perfect health when he sat down to his dinner at noon on May 7th.He made a good meal of beefsteak-pie and potatoes, and walked to his office as usual, a dis- tance of about a quarter of a mile.Wlthout aiiy apparent cause whatever, about two o'clock he was suddenly seized with excruciating pain in the epigastrium.He walked home at once with difficulty, and was "doubled up with pain"; he was given brandy and water, and a dose of castor-oil, after which he vomited for the first time about four o'clock.Pain and vomiting continued, with sleepleso nights, untiI the 9th, when he was so much easier that, in the afternoon, he sat out by the fire; but, in the evening, his symptoms returned, as severe as ever.3 it ~~6,, 7 to 1 case ,, ,
Effects of transdermal versus oral hormone replacement therapy on bone density in spine and proximal femur in postmenopausal women
Authors: J.C. Stevenson, M.P. Cust, K.F. Gangar, T.C. Hillard, B.L. Lees, M.P. Cust, K.F. Gangar, T.C. Hillard, M.I. Whitehead
Journal: The Lancet (1990)
An implausible model and evolutionary explanation of the revenge motive
Authors: Herbert Gintis
Journal: Behavioral and Brain Sciences (2012)

Abstract McCullough et al.'s target article is a psychological version of the reputation models pioneered by biologist Robert Trivers (1971) and economist Robert Frank (1988). The authors, like Trivers and Frank, offer an implausible explanation of the fact that revenge is common even when there are no possible reputational effects. I sketch a more plausible model based on recent research.
Suramin Inhibits Renal Fibrosis in Chronic Kidney Disease
Authors: Na Liu, Evelyn Tolbert, Maoyin Pang, Murugavel Ponnusamy, Haidong Yan, Shougang Zhuang
Journal: Journal of the American Society of Nephrology (2011)

The activation of cytokine and growth factor receptors associates with the development and progression of renal fibrosis. Suramin is a compound that inhibits the interaction of several cytokines and growth factors with their receptors, but whether suramin inhibits the progression of renal fibrosis is unknown. Here, treatment of cultured renal interstitial fibroblasts with suramin inhibited their activation induced by TGF-β1 and serum. In a mouse model of obstructive nephropathy, administration of a single dose of suramin immediately after ureteral obstruction abolished the expression of fibronectin, largely suppressed expression of α-SMA and type I collagen, and reduced the deposition of extracellular matrix proteins. Suramin also decreased the expression of multiple cytokines including TGF-β1 and reduced the interstitial infiltration of leukocytes. Moreover, suramin decreased expression of the type II TGF-β receptor, blocked phosphorylation of the EGF and PDGF receptors, and inactivated several signaling pathways associated with the progression of renal fibrosis. In a rat model of CKD, suramin abrogated proteinuria, limited the decline of renal function, and prevented glomerular and tubulointerstitial damage. Collectively, these findings indicate that suramin is a potent antifibrotic agent that may have therapeutic potential for patients with fibrotic kidney diseases.
Concluding Remarks: Tenth Conference on Cancer Therapy with Antibodies and Immunoconjugates
Authors: Sally J. DeNardo
Journal: Clinical Cancer Research (2005)

The articles presented at this Tenth Conference on Cancer Therapy with Antibodies and Immunoconjugates represent the maturation of the field to clinical practice and the promise of newer prospects to substantially enhance these therapies. Over 20 years, a tradition for creative interaction has been
Once-daily Fluticasone Furoate∗ Nasal Spray (FF) is Safe and Effective in The Long-term Treatment of Perennial Allergic Rhinitis (PAR) in Children Ages 2 to 11 Years ∗USAN approved name
Authors: J.F. Maspero, A. Rosenblut, A. Finn, J. Lim, W. Wu, M. Faris, E. Philpot
Journal: Journal of Allergy and Clinical Immunology (2007)
Caveolin-1 regulates leucocyte behaviour in fibrotic lung disease
Authors: Elena Tourkina, Mathieu Richard, James Oates, Ann Hofbauer, Michael Bonner, Pal Gööz, Richard Visconti, Jing Zhang, Sergei Znoyko, Corey M Hatfield, Richard M Silver, Stanley Hoffman
Journal: Annals of the Rheumatic Diseases (2010)

Objectives Reduced caveolin-1 levels in lung fibroblasts from patients with scleroderma and the lungs of bleomycin-treated mice promote collagen overexpression and lung fibrosis. This study was undertaken to determine whether caveolin-1 is deficient in leucocytes from bleomycin-treated mice and patients with scleroderma and to examine the consequences of this deficiency and its reversal. Methods Mice or cells received the caveolin-1 scaffolding domain (CSD) peptide to reverse the pathological effects of reduced caveolin-1 expression. In bleomycin-treated mice, the levels of caveolin-1 in leucocytes and the effect of CSD peptide on leucocyte accumulation in lung tissue were examined. To validate the results in human disease and to identify caveolin-1-regulated molecular mechanisms, monocytes and neutrophils were isolated from patients with scleroderma and control subjects and caveolin-1, extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), p38, CXC chemokine receptor 4 (CXCR4) and matrix metalloproteinase 9 (MMP-9) expression/activation were evaluated. These parameters were also studied in monocytes treated with cytokines or CSD peptide. Results Leucocyte caveolin-1 is important in lung fibrosis. In bleomycin-treated mice, caveolin-1 expression was diminished in monocytes and CSD peptide inhibited leucocyte recruitment into the lungs. These observations are relevant to human disease. Monocytes and neutrophils from patients with scleroderma contained less caveolin-1 and more activated ERK, JNK and p38 than those from control subjects. Treatment with CSD peptide reversed ERK, JNK and p38 hyperactivation. Scleroderma monocytes also overexpressed CXCR4 and MMP-9, which was inhibited by the CSD peptide. Cytokine treatment of normal monocytes caused adoption of the scleroderma phenotype (low caveolin-1, high CXCR4 and MMP-9 and signalling molecule hyperactivation). Conclusions Caveolin-1 downregulation in leucocytes contributes to fibrotic lung disease, highlighting caveolin-1 as a promising therapeutic target in scleroderma.
Knotting of scalp hair
Authors: RODNEY P.R. DAWBER
Journal: British Journal of Dermatology (1974)

A study has been made of the incidence of knotting in scalp hair of various types. Short curly hair of negroid and caucasoid type appeared particularly disposed to knot. Scanning electron microscopy of affected hairs showed marked disruption of the hair shaft structure in and adjacent to the knots.
Worth Adapting? Revisiting the Usefulness of Outcome-Adaptive Randomization
Authors: J. Jack Lee, Nan Chen, Guosheng Yin
Journal: Clinical Cancer Research (2012)

Abstract Outcome-adaptive randomization allocates more patients to the better treatments as the information accumulates in the trial. Is it worth it to apply outcome-adaptive randomization in clinical trials? Different views permeate the medical and statistical communities. We provide additional insights to the question by conducting extensive simulation studies. Trials are designed to maintain the type I error rate, achieve a specified power, and provide better treatment to patients. Generally speaking, equal randomization requires a smaller sample size and yields a smaller number of nonresponders than adaptive randomization by controlling type I and type II errors. Conversely, adaptive randomization produces a higher overall response rate than equal randomization with or without expanding the trial to the same maximum sample size. When there are substantial treatment differences, adaptive randomization can yield a higher overall response rate as well as a lower average sample size and a smaller number of nonresponders. Similar results are found for the survival endpoint. The differences between adaptive randomization and equal randomization quickly diminish with early stopping of a trial due to efficacy or futility. In summary, equal randomization maintains balanced allocation throughout the trial and reaches the specified statistical power with a smaller number of patients in the trial. If the trial's results are positive, equal randomization may lead to early approval of the treatment. Adaptive randomization focuses on treating patients best in the trial. Adaptive randomization may be preferred when the difference in efficacy between treatments is large or when the number of patients available is limited. Clin Cancer Res; 18(17); 4498–507. ©2012 AACR.
Comparative Study for the Detection of Antinuclear Factors with the Fluorescent Antibody Technique
Authors: W. Hijmans, H. R. E. Schuit, E. Mandema, R. L. F. Nienhuis, T. E. W. Feltkamp, E. J. Holborow, G. D. Johnson
Journal: Annals of the Rheumatic Diseases (1964)

forthe detection ofanti-nuclear factors inhumansera hasfound wideapplication fordiagnostic aswell as forresearch purposes sinceitsintroduction by Friou, Finch, andDetre(1957), Holborow, Weir, andJohnson (1957), andHolmanandKunkel (1957). Itisgenerally agreed thatthistestis positive inalmostallpatients suffering from systemic lupus erythematosus, andthat theincidence ofpositivity isverylowinhealthy subjects. The reported figures ontheincidence indiseased control groups, however, showsucha widevariation (Hijmans, 1963) thatitseemed advisable toinvestigatethepossible causes ofthese discrepancies. To thisenda comparative studywasundertaken in fourlaboratories, eachofwhichapplied oneor moredifferent systems toinvestigate thepresence ofanti-nuclear factor(s) (A.N.F.) inthesame hundred sera.
Short- and Long-Term Black Tea Consumption Reverses Endothelial Dysfunction in Patients With Coronary Artery Disease
Authors: Stephen J. Duffy, John F. Keaney Jr, Monika Holbrook, Noyan Gokce, Peter L. Swerdloff, Balz Frei, Joseph A. Vita
Journal: Circulation (2001)

Background — Epidemiological studies suggest that tea consumption decreases cardiovascular risk, but the mechanisms of benefit remain undefined. Endothelial dysfunction has been associated with coronary artery disease and increased oxidative stress. Some antioxidants have been shown to reverse endothelial dysfunction, and tea contains antioxidant flavonoids. Methods and Results — To test the hypothesis that tea consumption will reverse endothelial dysfunction, we randomized 66 patients with proven coronary artery disease to consume black tea and water in a crossover design. Short-term effects were examined 2 hours after consumption of 450 mL tea or water. Long-term effects were examined after consumption of 900 mL tea or water daily for 4 weeks. Vasomotor function of the brachial artery was examined at baseline and after each intervention with vascular ultrasound. Fifty patients completed the protocol and had technically suitable ultrasound measurements. Both short- and long-term tea consumption improved endothelium- dependent flow-mediated dilation of the brachial artery, whereas consumption of water had no effect ( P &lt;0.001 by repeated-measures ANOVA). Tea consumption had no effect on endothelium-independent nitroglycerin-induced dilation. An equivalent oral dose of caffeine (200 mg) had no short-term effect on flow-mediated dilation. Plasma flavonoids increased after short- and long-term tea consumption. Conclusions — Short- and long-term black tea consumption reverses endothelial vasomotor dysfunction in patients with coronary artery disease. This finding may partly explain the association between tea intake and decreased cardiovascular disease events.
EBV-positive diffuse large B-cell lymphoma in young adults: is this a distinct disease entity?
Authors: J.Y. Hong, D.H. Yoon, C. Suh, J. Huh, I.-G. Do, I. Sohn, J. Jo, S.-H. Jung, M.E. Hong, H. Yoon, Y.H. Ko, S.J. Kim, W.S. Kim
Journal: Annals of Oncology (2014)
Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a<i>Borrelia burgdorferi</i>peptide
Authors: Allen C. Steere, William Klitz, Elise E. Drouin, Ben A. Falk, William W. Kwok, Gerald T. Nepom, Lee Ann Baxter-Lowe
Journal: The Journal of Experimental Medicine (2006)

An association has previously been shown between antibiotic-refractory Lyme arthritis, the human histocompatibility leukocyte antigen (HLA)-DR4 molecule, and T cell recognition of an epitope of Borrelia burgdorferi outer-surface protein A (OspA163-175). We studied the frequencies of HLA-DRB1-DQA1-DQB1 haplotypes in 121 patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis and correlated these frequencies with in vitro binding of the OspA163-175 peptide to 14 DRB molecules. Among the 121 patients, the frequencies of HLA-DRB1-DQA1-DQB1 haplotypes were similar to those in control subjects. However, when stratified by antibiotic response, the frequencies of DRB1 alleles in the 71 patients with antibiotic-refractory arthritis differed significantly from those in the 50 antibiotic-responsive patients (log likelihood test, P = 0.006; exact test, P = 0.008; effect size, Wn = 0.38). 7 of the 14 DRB molecules (DRB1*0401, 0101, 0404, 0405, DRB5*0101, DRB1*0402, and 0102) showed strong to weak binding of OspA163-175, whereas the other seven showed negligible or no binding of the peptide. Altogether, 79% of the antibiotic-refractory patients had at least one of the seven known OspA peptide-binding DR molecules compared with 46% of the antibiotic-responsive patients (odds ratio = 4.4; P < 0.001). We conclude that binding of a single spirochetal peptide to certain DRB molecules is a marker for antibiotic-refractory Lyme arthritis and might play a role in the pathogenesis of the disease.
A Potent Immunogenic General Cancer Vaccine That Targets Survivin, an Inhibitor of Apoptosis Proteins
Authors: Satomi Idenoue, Yoshihiko Hirohashi, Toshihiko Torigoe, Yuriko Sato, Yasuaki Tamura, Hiroyuki Hariu, Masaaki Yamamoto, Takehiro Kurotaki, Tetsuhiro Tsuruma, Hiroko Asanuma, Takayuki Kanaseki, Hideyuki Ikeda, Kiyoteru Kashiwagi, Minoru Okazaki, Kazuaki Sasaki, Takashi Sato, Tousei Ohmura, Fumitake Hata, Koji Yamaguchi, Koichi Hirata, Noriyuki Sato
Journal: Clinical Cancer Research (2005)

Abstract We reported previously a HLA-A24-restricted antigenic peptide, survivin-2B80-88 (AYACNTSTL), recognized by CD8+ CTL. This peptide was derived from survivin protein, an inhibitor of apoptosis proteins, expressed in a variety of tumors, such as adenocarcinoma, squamous cell carcinoma, and malignant melanoma. In this report, we provide further evidence that survivin-2B80-88 peptide might serve as a potent immunogenic cancer vaccine for various cancer patients. Overexpression of survivin was detected in surgically resected primary tumor specimens of most breast and colorectal cancers and some gastric cancers as assessed by immunohistochemical study. HLA-A24/survivin-2B80-88 tetramer analysis revealed that there existed an increased number of CTL precursors in peripheral blood mononuclear cells (PBMC) of HLA-A24+ cancer patients, and in vitro stimulation of PBMCs from six breast cancer patients with survivin-2B80-88 peptide could lead to increases of the CTL precursor frequency. Furthermore, CTLs specific for this peptide were successfully induced from PBMCs in all 7 (100%) patients with breast cancers, 6 of 7 (83%) patients with colorectal cancers, and 4 of 7 (57%) patients with gastric cancers. These data indicate that survivin expressed in tumor tissues is antigenic in cancer patients, and survivin-2B80-88-specific CTLs are present in PBMCs of various cancer patients. Our study raises the possibility that this peptide may be applicable as a general cancer vaccine to a large proportion of HLA-A24+ cancer patients.
Computed Tomography in the Evaluation of Cystic Fibrosis Lung Disease
Authors: Alan S. Brody, Harm A. W. M. Tiddens, Robert G. Castile, Harvey O. Coxson, Pim A. de Jong, Jonathan Goldin, Walter Huda, Frederick R. Long, Michael McNitt-Gray, Michael Rock, Terry E. Robinson, Scott D. Sagel
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

The first report of computed tomography (CT) scanning to monitor cystic fibrosis (CF)-related lung disease was published in 1986. Further publications followed, but in general there was little interest in this technique until recently. Two factors in particular have led to this increased interest. First is an increasing realization that pulmonary function tests, long the mainstay of CF evaluation, often underestimate the presence and severity of mild and moderate lung disease. Second is the need for more sensitive outcome measures to assess new therapies. This had led to new interest and a series of important publications. The goal of this article is to present the current status of CT scanning in CF.
A guide to the translation of the Global Initiative for Asthma (GINA) strategy into improved care
Authors: Louis-Philippe Boulet, J. Mark FitzGerald, Mark L. Levy, Alvaro A. Cruz, Soren Pedersen, Tari Haahtela, Eric D. Bateman
Journal: European Respiratory Journal (2012)

In 1995, the Global Initiative for Asthma (GINA) published an evidence-based workshop report as a guide to clinicians managing asthma patients, and has updated it annually to ensure that recommendations remain current. Although the report has been widely disseminated and influenced clinical practice and research, its major objective, of forming the basis for local and national initiatives to improve services for asthma patients, remains to be achieved. Over recent years, the science of guideline implementation has progressed, and encouraging examples of successful asthma programmes have been published. This report is intended to draw on this experience and assist with the translation of asthma guideline recommendations into quality programmes for patients with asthma using current knowledge translation principles. It also provides examples of successful initiatives in various socioeconomic settings.
Hypogeusia, Anorexia, and Altered Zinc Metabolism Following Thermal Burn
Authors: I. Kelman Cohen
Journal: JAMA (1973)

Taste acuity and zinc and copper metabolism were studied in 19 patients with thermal burns. Eighty-four percent exhibited hypogeusia (decreased taste acuity). Mean serum total zinc concentration was decreased and mean urinary zinc excretion was increased in the patients with hypogeusia compared to controls. An association among hypogeusia, anorexia, and altered zinc metabolism after thermal injury is strongly suggested.
TGF-β, IL-1β, And IL-23 Are Required For IL-13Rα1 Expression On Human Th17 Cells And IL-13 Attenuates IL-17A Production At Restimulation
Authors: M.M. Huckabee, D.C. Newcomb, M.G. Boswell, K. Goleniewska, S. Reiss, R.S. Peebles Jr.
Journal: Journal of Allergy and Clinical Immunology (2011)
IgE and non-IgE mediated allergic disorders in systemic lupus erythematosus
Authors: S Morton, B Palmer, K Muir, R J Powell
Journal: Annals of the Rheumatic Diseases (1998)

To ascertain the prevalence of IgE and non-IgE mediated allergic disorders in patients with systemic lupus erythematosus (SLE).49 SLE cases (all satisfying at least four "Revised ARA Criteria") and 98 healthy, age, and sex matched controls (randomly selected through two urban general practices and one rural general practice) were interviewed by telephone to screen for a history of allergy. Subjects with a history of allergic rhinitis, asthma or atopic eczema then underwent skin prick testing to confirm underlying IgE mediated disease.Analysis of the data by conditional logistic regression revealed no significant difference in frequency of allergic disorders in SLE cases and controls (odds ratio (OR) 0.92, 95% confidence intervals (CI) 0.45, 1.86). In addition a subgroup analysis of subjects with IgE mediated/associated atopic disorders, showed that cases and controls were at a similar risk of having these conditions (OR 0.90, 95% CI 0.41, 1.96).This study suggests that people with SLE are not at an increased risk of IgE mediated/associated allergic disorders, in contrast with previous reports.
Ebola virus claims more lives in Uganda
Authors: R. MacDonald
Journal: BMJ (2000)

The recent outbreak of Ebola haemorrhagic fever in the Gulu district of Uganda is continuing to claim lives. As the BMJ went to press, the death toll was 60, with 165 cases having been reported.

The National Institute of Virology in South Africa confirmed that the Ebola virus was the cause of the outbreak on 16 October, when 81 cases were reported, including 35 deaths.

This is the first known outbreak of …