tbuckley/cabot-search huggingface dataset:
Dextromethorphan-Quinidine for Agitation in Alzheimer Disease
Authors: John C. Newman, Michael A. Steinman
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rates of Youth Obesity Increase Around the World
Authors: M. J. Friedrich
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adhesion, Transendothelial Migration, and Reverse Transmigration of In Vitro Cultured Dendritic Cells
Authors: Giovanna D'Amico, Giancarlo Bianchi, Sergio Bernasconi, Laura Bersani, Lorenzo Piemonti, Silvano Sozzani, Alberto Mantovani, Paola Allavena
Journal: Blood (1998)
Doctors cite lack of time as greatest barrier to research
Authors: Anne Gulland
Journal: BMJ (2016)

A lack of time and money are the biggest barriers to doctors undertaking research, a report by the Royal College of Physicians has found.1

The survey of 2000 doctors asked them to rate a variety of barriers to research on a scale from zero to five. The barriers that respondents rated as having the biggest impact were difficulties in applying for, and receiving, both protected time and funding.

Respondents also said that the ethics approval process put them off—although the survey was carried out before the introduction of the simplified …
Massachusetts Medical Society
Authors: Robert J. Haggerty
Journal: New England Journal of Medicine (1957)

TOXIC HAZARDS*The Boston Poison Information Center†Accidents are now the leading cause of death from one to thirty-four years of age. In New York City in 1954 they were responsible for more deaths in children under five years of age than twice the number of the 10 leading communicable diseases.‡ Poisonings, which account for about 8 per cent of these accidental deaths, cause more than 800 childhood deaths per year in the United States. With the marked decrease in deaths from infection, deaths from accidental poisoning have assumed relatively greater importance and have aroused increasing interest among the medical . . .
Cover Image: A dashed hair
Authors: R. Pirmez, M. del Rei
Journal: British Journal of Dermatology (2016)

We read the response to our manuscript 1 by Professor Langan and her group. 2Indeed, not all studies have been limited to single centres with smaller cohorts.We were aware of their excellent studies of pemphigus and pemphigoid and certainly did not mean to ignore them.The studies of Langan et al. were performed in a unique clinical database that used Read codes, which are standard in U.K. general practice. [3]4][5] We did not address the studies of Langan et al. because our goal was to validate search strategies by International Classification of Diseases codes, which are employed by many clinical databases in the U.S.A. and internationally.This validation will serve as an important methodological background to a number of epidemiological studies of pemphigus and pemphigoid that are under way.
Ascertainment of the Incidence of Beckwith-Wiedemann Syndrome in the National Wilms Tumor Study Group
Authors: Richard Grundy, Jon Pritchard, Lisa Diller
Journal: Journal of Clinical Oncology (2001)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.2.593 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11208855 Ascertainment of the Incidence of Beckwith-Wiedemann Syndrome in the National Wilms Tumor Study Group Richard GrundyxRichard GrundySearch for articles by this author , Jon PritchardxJon PritchardSearch for articles by this author Lisa DillerxLisa DillerSearch for articles by this author Show More Institute of Child Health, University of Birmingham, Birmingham, United KingdomInstitute of Child Health, London, United KingdomDana-Farber Cancer Institute, Boston, MA https://doi.org/10.1200/JCO.2001.19.2.593 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical OncologyjcoJ Clin OncolJournal of Clinical OncologyJCO0732-183X1527-7755American Society of Clinical OncologyResponse15012001In Reply:We agree with Drs Grundy and Pritchard that one must analyze the data presented in our report1 in light of the methodology used. They are correct that central review of the cases, in terms of the presence or absence of overgrowth syndromes, was not performed. Patients were classified as having Beckwith-Wiedemann syndrome (BWS) if they were reported as such by their primary treating oncologist. This could have resulted in misclassification and an overestimate or underestimate of the number of BWS patients in the data set. Clinical examination of the patients suspected of having BWS was beyond the scope of our study. One must interpret the data regarding Wilms’ tumor and BWS keeping these limitations in mind. A possible strength of this method is that patients were classified as having BWS if their clinical oncologist thought they had BWS. This may be an imprecise but clinically relevant way of looking at the problem.REFERENCE1. Porteus MH, Narkool P, Neuberg D, et al: Characteristics and outcome of children with Beckwith-Wiedemann syndrome and Wilms’ tumor: A report from the National Wilms Tumor Study Group. J Clin Oncol 18:: 2026,2000-2031, Link, Google Scholar
Linear Vesicles in Newborn Resolving With Hyperpigmented Macules
Authors: José María Ortiz Salvador, Lorena Martínez Leborans, Altea Esteve Martínez
Journal: JAMA Dermatology (2016)

A newborn presented with vesicular lesions over trunk and lower extremities that had begun 2 days prior; physical examination revealed vesicles filled with clear fluid disposed in a linear arrangement forming whorls and swirls. What is your diagnosis?
No Major Complications In Children After Stem Cell Donation At One Year Follow-Up: EBMT Pediatric Diseases Working Party Study
Authors: Jan Styczynski, Lidia Gil, Franca Fagioli, Sarah Marktel, Adriana Balduzzi, Daniela Janeckova, Karoline Ehlert, Jean-Hugues Dalle, Jacek Wachowiak, Maurizio Miano, Chiara Messina, M.A. Diaz, Isabel Badell, Peter Dreger, Giorgio Dini, Christina Peters
Journal: Blood (2013)
Psychosexual and cultural determinants of fertility choice behavior
Authors: J Cawte
Journal: American Journal of Psychiatry (1975)

Although traditional societies in Oceania direct their fertility choice behavior (if any) toward spirits rather than sexual intercourse, closer observation shows that these fertility choice behaviors, while groping and magical, sometimes have empirical value. The author notes that the alternative to effective fertility control in these societies has sometimes been population regulation of the Malthusian variety (e.g., murder and starvation). Efforts aimed at spacing the family in a less savage and more effective manner deserve encouragement, the author believes.
Seeking Balance Between Pain Relief and Safety
Authors: William Renthal
Journal: JAMA Neurology (2016)

Pain is a symptom common tonumerousphysical andpsychiatric ailments andcanoftenbemanagedby treating theunderlyingcondition.However, inapproximately20millionpatients eachyear,chronicpainpersistsdespitetreatment.1,2Chronicpain is complex, heterogeneous, and poorly understood. Patientswithchronicpainexperience a decreased quality of lifeandincreasedrisk formultiplecomorbidities,costingsocietybillionsofdollars in reducedproductivityannually.Therefore,equippingphysicianswitheffectivetoolsandguidelinesfor chronic painmanagement is of paramount importance. Chronicpaincanbemanagedwithbothpharmacologicand nonpharmacologic options, such as behavioral and physical therapy. Unfortunately, insurance coverage for multidisciplinary painmanagement is limited,whichplacesmuchof the responsibility for treatingchronicpainonprimarycareandprescriptionmedications.Multiplepharmacologicoptionsareavailable, including nonsteroidal anti-inflammatory drugs, antidepressants, anticonvulsants, andopioids,but it is rarelypossible to predict the safest andmost effectivemedication for a given patient. Moreover, there is a paucity of clinical trials to guide physicians in treating chronic pain. In some cases, opioids are the only class ofmedications to which a patient responds, but becauseofdangerousadverseeffects, including respiratorydepression, unintentional overdose, and addiction, it is important for physicians, especially those inprimary care, to be confident with prescribing them safely. The clinical decision to prescribe opioids must also be made in the setting of increases in opioid prescriptions and prescription opioid–related deaths, which now exceed 200 million prescriptions and 16000 deaths per year (Figure). About half of those who died had an active opioid prescription; the other half obtained opioids through pill diversion.5 Notably, among diverted opioid prescriptions, more than 50% are obtained freely from a family member or friend with a valid prescription. This reality forces prescribing physicians to simultaneously address the risk for opioid overdose in their own patients, as well as the risk of prescriptions being diverted and harming others. Related article at jama.com Related article at jamainternalmedicine.com Figure. Opioid Prescriptions andOpioid-Related Deaths From 1999-2013
Inverse Relationship Between Fractionated Electrograms and Atrial Fibrosis in Persistent Atrial Fibrillation
Authors: Amir S. Jadidi, Hubert Cochet, Ashok J. Shah, Steven J. Kim, Edward Duncan, Shinsuke Miyazaki, Maxime Sermesant, Heiko Lehrmann, Matthieu Lederlin, Nick Linton, Andrei Forclaz, Isabelle Nault, Lena Rivard, Matthew Wright, Xingpeng Liu, Daniel Scherr, Stephen B. Wilton, Laurent Roten, Patrizio Pascale, Nicolas Derval, Frédéric Sacher, Sebastien Knecht, Cornelius Keyl, Mélèze Hocini, Michel Montaudon, Francois Laurent, Michel Haïssaguerre, Pierre Jaïs
Journal: Journal of the American College of Cardiology (2013)
Abrupt quitting is more likely to work than gradual reduction of cigarettes, study finds
Authors: Jacqui Wise
Journal: BMJ (2016)

Quitting smoking abruptly is more likely to lead to sustained abstinence than reducing cigarette use gradually, a study published in the Annals of Internal Medicine has found.1

Although most current guidelines recommend stopping smoking abruptly, many people take a gradual approach to giving up.

The study randomly assigned 697 adult smokers from 31 primary care …
Bleomycin in germ cell tumor therapy: not all regimens are created equal.
Authors: D F Bajorin, G J Bosl
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.5.1717 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9164177 Bleomycin in germ cell tumor therapy: not all regimens are created equal. D F BajorinxD F BajorinSearch for articles by this author , G J BoslxG J BoslSearch for articles by this author https://doi.org/10.1200/JCO.1997.15.5.1717 First Page PDF © 1997 by American Society of Clinical Oncology
Induction of Transitional Cell Carcinomas of the Urinary Bladder in Monkeys Fed 2-Naphthylamine&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Gaylord M. Conzelman, Jr., Jack E. Moulton, Lloyd E. Flanders, III, Katharine Springer, Daniel W. Crout
Journal: JNCI Journal of the National Cancer Institute (1969)

Transitional cell carcinomas of the urinary bladder were induced within 60 months (earliest carcinoma, 33 months) in 9 of 24 rhesus monkeys given 2-naphthylamine orally. The spectrum of neoplasia extended from benign papilloma to invasive carcinoma. Pathology other than carcinoma was observed in the urinary tract of some animals. The oral dosage ranged from 6.25 mg/kg/day to 400 mg/kg/day. Although a dose-response relationship was apparent, there were tumor-free animals that received high doses for long periods. On the other hand, a few monkeys received low doses, but presented small tumors at necropsy. Many urinary bladders examined at autopsy had multiple lesions. In some cases, papilloma, carcinoma in situ, and invasive carcinoma were found in the same bladder. Hydronephrosis was observed in 3 animals with obstructive carcinomas.
Methotrexate (MTX), procarbazine and CCNU for primary central nervous system lymphoma (PCNSL) in patients younger than 60: Can radiotherapy (RT) be deferred?
Authors: A. M. Omuro, L. Taillandier, O. Chinot, C. Carnin, M. Barrie, C. Soussain, V. Leblond, K. Hoang-Xuan
Journal: Journal of Clinical Oncology (2006)

1551 Background: Deferring RT following MTX based chemotherapy has been an acceptable initial approach for elderly PCNSL pts because of a high risk of neurotoxicity (NT). However, given the lower NT risk, such an approach is more controversial in younger pts . In this study we report outcomes of an innovative MTX-based regimen for PCNSL pts younger than 60 and seek to investigate whether withholding RT is an acceptable option in selected pts. Methods: We reviewed records of all patients &lt;60y with confirmed PCNSL seen in 3 institutions from 1994 to 2003. Through prior agreement among institutions, pts were offered a standardized treatment consisting of an induction chemotherapy with MTX (3g/m 2 - days 1, 10, and 20), CCNU (40 mg/m 2 - day 1), procarbazine (60 mg/m 2 - days 1–7), methylprednisolone (120 mg/m 2 - days 1–20) and IT MTX (15mg), cytarabine (40 mg) and methylprednisolone (40mg)- days 1, 5, 10 and 15. Pts with a complete response (CR) proceeded to a maintenance chemotherapy consisting of 5 monthly cycles with same doses of MTX- day 1, CCNU- day 1, procarbazine- days 1–7, and same IT chemotherapy on day 1; those patients received no further treatment. Pts with less than a CR to induction were treated on an individual basis, and typically received consolidation with RT or high-dose chemotherapy (HDC) with stem cell rescue. Results: Among the 64 identified pts, median age was 47 (19–60), median KPS was 70 (20–100), and 41 (64%) were men. For the entire population, median progression-free survival (PFS) was 13m and median overall survival (OS) has not been reached (median follow-up: 54m). 90% of patients responded to induction treatment (CR: 52%; PR: 38%). Consolidation or salvage treatment with RT has been given to a total of 27 pts, and HDC to 23. For the 26 pts who completed maintenance chemotherapy and received no further treatment, median PFS was 36m. Grades 3/4 hematotoxicity developed in 18 pts, nephrotoxicity in 2 pts, and NT in 6 patients (none in the chemotherapy-only treated patients). Two toxic deaths occurred. Conclusions: Deferring RT in chemosensitive patients seems to compromise PFS but not OS, with minimal NT. HDC and RT are effective salvage treatments. Further studies on the role of RT versus HDC in younger patients are warranted. No significant financial relationships to disclose.
Pruritus as a Paraneoplastic Symptom of Thymoma
Authors: Sukhmani K. Padda, Joseph B. Shrager, Jonathan W. Riess, Judy Y. Pagtama, Alison J. Holmes Tisch, Bernice Y. Kwong, Ying Liang, Erich J. Schwartz, Billy W. Loo, Joel W. Neal, Russell Hardy, Heather A. Wakelee
Journal: Journal of Thoracic Oncology (2015)
Cmet Expression and Activity of First-Line Erlotinib in Advanced Non-Small Cell Lung Cancer (Nsclc) Patients (Pts): Exploratory Analysis of the Randomized Phase III Torch Trial
Authors: M. Tsao, M. Di Maio, L. Kim, G. Liu, J. Xu, V. Gebbia, M.A. Burgio, Z.Y. Alam, G. Valmadre, B. Higgins, S. Signoriello, A. Rossi, N.B. Leighl, P. Maione, C.A. Butts, F. Ciardiello, R. Feld, C. Gallo, C. Gridelli, F. Perrone
Journal: Annals of Oncology (2014)
Some Properties of a New Epithelial Cell Line of Human Origin&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: J A Sykes, J Whitescarver, P Jernstrom, J F Nolan, P Byatt
Journal: JNCI Journal of the National Cancer Institute (1970)

A new human cell line (ME-180) was established from an omental metastasis of a rapidly spreading cervical carcinoma. The cell type was epithelial, as demonstrated by cytoplasmic tonofibrils and desmosomal attachments between the cells in monolayer cultures. Chromosomal number ranged from 48–130; fragmentation, dicentrics, and other chromosomal rearrangements characteristic of transformed cells were noted. Occasional marker chromosomes were seen but formed no stemline. ME-180 can be classified as heteroploid with a subtriploid mode and unstable karyotype. The sensitivity toward a number of viruses differed from that of He La cells studied simultaneously. ME-180 cells readily formed carrier cultures with some viruses, particularly with influenza and other myxoviruses.
PTH-328 High resolution spectral imaging: novel diagnostics in colorectal cancer
Authors: R Griggs, J Nallala, G Lloyd, T Cook, C Kendall, H Barr, N Shepherd, N Stone
Journal: Gut (2015)

<h3>Introduction</h3> Colorectal cancer is the second most common cause of cancer death in the UK and accounts for 13% of all new cancer cases each year.<sup>1</sup>Most of these arise from pre-existing adenomatous polyps.<sup>2</sup>Recent research has supported an early diagnosis and prevention approach with the aim of improving survival and reducing overall mortality from colorectal cancer death.<sup>3</sup>The Bowel Cancer Screening Programme (BCSP) was commenced to drive early diagnosis of colorectal cancer but generates a huge volume of tissue for analysis from biopsy and polypectomy. The aim of this study was to investigate and demonstrate the use of novel high resolution infrared spectroscopy in colonic tissue to differentiate and classify a representative range of abnormal pathologies. <h3>Method</h3> 65 cases from 5 different pathology groups were identified from 2010 to 2014. These formalin-fixed and paraffin-embedded samples were routinely processed and thin sections placed on calcium fluoride slides. High resolution infrared imaging with a pixel resolution of 1.1 microns was performed on the tissue and the absorption spectra measured for each case. Accepted methods of multivariate spectral analysis were undertaken to elucidate the spectral differences across the dataset and classify the tissue spectra representative of the tissue biochemistry. <h3>Results</h3> High resolution infrared spectral imaging was successfully performed on thin sections of unstained colonic tissue. Specimen analysis generated over 1.5 million spectra which were used to discriminate the 5 pathological groups. The epithelial spectra from each case were identified and then principal component and linear discriminant analysis applied, and a classification model built to demonstrate the spectral differences. Leave one sample out cross validation (LOSOCV) resulted in a sensitivity of 65% and specificity of 82.3% for the technique to successfully discriminate normal from cancerous tissue. Dysplasia and cancer were also successfully discriminated with a sensitivity of 75.3% and specificity of 61.3%. <h3>Conclusion</h3> High resolution infrared spectral imaging is a novel technique which has been proven to be successful, reliable and rapid in the analysis of paraffin-embedded colonic pathology. It demonstrates suitability for automated analysis of specimens and therefore the potential for use as an adjunct in the diagnostic pathway for both early polyp and invasive cancer, particularly in high volume BCSP cases or where the traditional pathological diagnosis is time-consuming or difficult. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> www.cancerresearchuk.org Scholefield JH. <i>BMJ</i>. 2000;<b>321</b>:1004–6 Winawer SJ, Fletcher RH, Miller L, <i>et al</i>. Gastroenterology. 1997;112:594–642
Possible Role of Glutathione in the Antitumor Effect of a Copper-Containing Synthetic Superoxide Dismutase in Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: L W Oberley, K L Rogers, L Schutt, T D Oberley, S W Leuthauser, J R Sorenson
Journal: JNCI Journal of the National Cancer Institute (1983)

The effect of glutathione and a glutathione reductase inhibitor on the antitumor effect of Cu(II)(3,5-diisopropylsalicylate)2 (CuDIPS) was studied. CuDIPS is a low-molecular-weight copper coordination compound that exhibits superoxide dismutase-like activity. CuDIPS had antitumor activity against intraperitoneal Ehrlich ascites carcinoma in Swiss mice. A single ip injection of glutathione partially eliminated the antitumor effect of CuDIPS, whereas a single ip injection of 1,3-bis(2-chloroethyl)-1-nitrosourea enhanced the antitumor effect of CuDIPS. These results are consistent with the hypothesis that CuDIPS exerts part of its antitumor effect by producing H2O2.
Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma
Authors: L Pasqualucci, M Wasik, BA Teicher, L Flenghi, A Bolognesi, F Stirpe, L Polito, B Falini, ME Kadin
Journal: Blood (1995)