tbuckley/cabot-search huggingface dataset:
Thermal Enhancement of Thio-TEPA Cytotoxicity2
Authors: Horton A. Johnson, Mildred Pavelec
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Thermal Enhancement of Thio-TEPA Cytotoxicity Get access Horton A. Johnson, Horton A. Johnson Medical Department, Brookhaven National Laboratory, Upton, New York 11973; and Department of Pathology, Indiana University Medical Center, Indianapolis, Indiana 46202 Search for other works by this author on: Oxford Academic PubMed Google Scholar Mildred Pavelec Mildred Pavelec Medical Department, Brookhaven National Laboratory, Upton, New York 11973; and Department of Pathology, Indiana University Medical Center, Indianapolis, Indiana 46202 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 50, Issue 4, April 1973, Pages 903–908, https://doi.org/10.1093/jnci/50.4.903 Published: 01 April 1973 Article history Received: 03 June 1972 Accepted: 16 November 1972 Published: 01 April 1973
BMET-05NCCTG N0574 (ALLIANCE): A PHASE III RANDOMIZED TRIAL OF WHOLE BRAIN RADIATION THERAPY (WBRT) IN ADDITION TO RADIOSURGERY (SRS) IN PATIENTS WITH 1 TO 3 BRAIN METASTASES
Authors: Paul Brown, Anthony Asher, Karla Ballman, Elana Farace, Jane Cerhan, S. Keith Anderson, Xiomara Carrero, Fred Barker, Richard Deming, Stuart Burri, Cynthia Ménard, Caroline Chung, Volker Stieber, Bruce Pollock, Eva Galanis, Jan Buckner, Kurt Jaeckle
Journal: Neuro-Oncology (2015)

BACKGROUND: WBRT significantly improves tumor control in the brain after SRS, yet the role of adjuvant WBRT remains undefined due to concerns regarding neurocognitive risks. METHODS: Patients with 1-3 brain metastases, each  1 SD from baseline in any of the 6 cognitive tests at 3 months. Time to CP was estimated using cumulative incidence adjusting for survival as a competing risk. RESULTS: 213 patients were enrolled with 2 ineligible and 3 cancels prior to receiving treatment. Baseline characteristics were well-balanced between study arms. The median age was 60 and lung primary the most common (68%). CP at 3 months was more frequent after WBRT + SRS vs. SRS alone (91.7% vs. 63.5% respectively, p = 0.0007). There was more deterioration in the WBRT + SRS arm in immediate recall (30% vs. 8%, p = 0.0043), delayed recall (51% vs. 20%, p = 0.0009), and verbal fluency (19% vs. 2%, p = 0.0098). After WBRT + SRS there was more deterioration in overall QOL (p = 0.001) and functional well-being (p = 0.006) at 3months. Intracranial tumor control at 3 and 6 months were 75.3% and 64.7% with SRS alone vs. 93.7% and 88.4% with SRS + WBRT (p < 0.0001). Median OS was 10.4 for SRS alone vs. 7.4 months for SRS + WBRT respectively (HR = 1.02, p = 0.92). CONCLUSIONS: Decline in QOL and cognitive function, specifically immediate recall, memory and verbal fluency, was more frequent with the addition of WBRT to SRS. Adjuvant WBRT did not improve OS despite better brain control. Initial treatment with SRS and close monitoring is recommended to better preserve cognitive function in patients with newly diagnosed brain metastases that are amenable to SRS.
BCR Hyper-Responsiveness In B Cells From Patients With Chronic Gvhd Is Blocked With The Syk Inhibitor R406
Authors: Jessica L. Allen, Prasanthi V. Tata, Jenna Wooten, Matthew S. Fore, Allison M. Deal, Andrew Sharf, Todd Hoffert, Philip A. Roehrs, Paul M. Armistead, James Coghill, William A. Wood, Thomas C. Shea, Jonathan Serody, Kristy L. Richards, Madan Jagasia, Stephanie J. Lee, Krista Rowe, David Rizzieri, Mitchell E. Horwitz, Nelson J. Chao, Stefanie Sarantopoulos
Journal: Blood (2013)
ATCT-12RESULTS OF NRG ONCOLOGY/RTOG 9813- A PHASE III RANDOMIZED STUDY OF RADIATION THERAPY (RT) AND TEMOZOLOMIDE (TMZ) VERSUS RT AND NITROSOUREA (NU) THERAPY FOR ANAPLASTIC ASTROCYTOMA (AA)
Authors: Susan Chang, Peixin Zhang, J. Gregory Cairncross, Mark R. Gilbert, Jean Paul Bahary, Carol Dolinskas, Kenneth D. Aldape, Erica Bell, David Sciff, Kurt Jaeckle, Paul D. Brown, Geoffrey R. Barger, Maria Werner-Wasik, Helen Shih, David Brachman, Marta Penas Prado, H. Ian Robins, Karl Belanger, Christopher J. Schultz, Arnab Chakravarti, Minesh Mehta
Journal: Neuro-Oncology (2015)
Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art
Authors: Sean R. Marcsisin, Gregory Reichard, Brandon S. Pybus
Journal: Pharmacology & Therapeutics (2016)

Primaquine is the only antimalarial drug available to clinicians for the treatment of relapsing forms of malaria. Primaquine development and usage dates back to the 1940s and has been administered to millions of individuals to treat and eliminate malaria infections. Primaquine therapy is not without disadvantages, however, as it can cause life threatening hemolysis in humans with glucose-6-phosphate dehydrogenase (G6PD) deficiency. In addition, the efficacy of primaquine against relapsing malaria was recently linked to CYP 2D6 mediated activation to an active metabolite, the structure of which has escaped definitive identification for over 75 years. CYP 2D6 is highly polymorphic among various human populations adding further complexity to a comprehensive understanding of primaquine pharmacology. This review aims to discuss primaquine pharmacology in the context of state of the art understanding of CYP 2D6 mediated 8-aminoquinoline metabolic activation, and shed light on the current knowledge gaps of 8-aminoquinoline mechanistic understanding against relapsing malaria.
Challenges of in-competition cardiac screening: lessons from the 12th FINA World Swimming Championships (25 m) Swimmer's Heart project: Table 1
Authors: H Paul Dijkstra, M Mountjoy, C Adamuz, A Pelliccia
Journal: British Journal of Sports Medicine (2016)

Ensuring the health of the elite athlete is embedded in the Olympic Movement Medical Code,1 and a top priority for International Sports Federations (IF).2 With this objective in mind, cardiovascular preparticipation screening (PPS) is now widely advocated.3–5 While seen as a necessary step in the prevention of the often silent conditions associated with sudden cardiac death (SCD), reports documenting its implementation among the various IFs are sparse. Fifty-six per cent of IFs currently implement PPS,2 however, only FIFA has documented their findings regarding the feasibility of such practice.

The adaptive response to intensive continuous exercise varies greatly depending on the sport played, and so the determination of normative cardiac values per sport has benefits when interpreting the standardised, sport-unspecific guidelines currently in place. The selection bias among some sports may also lead to a greater incidence of pathology associated with SCD.6 

One of the challenges often faced by IF's in implementing a successful screening programme is the global representation of athletes. Historically, it was therefore …
Loss of Ability to Synthesize Collagen in Fibroblasts Transformed by Rous Sarcoma Virus 2
Authors: Warren Levinson, Rajendra S. Bhatnagar, Tsan-Zon Liu
Journal: JNCI Journal of the National Cancer Institute (1975)

Transformation of chick embryo fibroblasts by Rous sarcoma virus inhibited their ability to synthesize collagen- Kinetic experiments showed that 72 hours after infection, collagen synthesis was reduced by 90%. Nontransforming Rous-associated viruses did not inhibit collagen synthesis. The inhibition resulted from the failure of the cells to synthesize collagen polypeptides rather than from a decrease in the activity of prolyl hydroxylase; the levels of prolyl hydroxylase were fourfold those in uninfected cells. The addition of dibutyryl cyclic AMP and theophylline, alone or together, did not restore collagen synthesis.
Clinical Study of Recombinant DNA-Produced Leukocyte Interferon (Clone A) in an Intermittent Schedule in Cancer Patients&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Quesada, Jorge R., Gutterman, Jordan U.
Journal: JNCI Journal of the National Cancer Institute (1983)

The effects of recombinant DNA-produced leukocyte interferon (IFLrA) were studied in 37 patients with metastatic cancer who received sequentially escalating doses of 9-86 million units (MU) of IFLrA by im injection twice weekly. The IFLrA was absorbed rapidly and reached a peak serum concentration 6-8 hours after injection. Serum concentration of IFLrA increased proportionately with the dose. The most common side effects included fever, chills, asthenia, anorexia, and weight loss, and leukopenia, granulocytopenia, and lymphopenia occurred frequently. Elevation of serum glutamic-oxaloacetic transaminase was frequent above doses of 50 MU. All side effects were reversible by discontinuation of the drug. Antibodies to IFLrA were detected in 3 patients while on treatment. The presence of antibodies coincided with drastic reduction in serum IFLrA concentration and, in 1 patient, with relapse of disease. Objective tumor responses were documented in patients with lymphomas but not in other groups of patients.
Abstract 137: VCAM1 and SIRPA Cell Surface Markers of Human Cardiomyocytes
Authors: Rhys J Skelton, Deevina Arasaratnam, Ben W Finnin, John M Haynes, Anthony White, Reza Ardehali, Andrew G Elefanty, Edouard G Stanley, David A Elliott
Journal: Circulation Research (2013)

Heart disease is the leading cause of mortality and morbidity in the Western world. The human heart has a limited regenerative capacity and there is an unmet demand for improved therapies for myocardial disease. Human stem cell derived cardiomyocytes have potential to facilitate the development of both cell based and pharmaceutical treatments. To date many studies have focused on the efficient generation of cardiomyocytes from pluripotent hESCs and iPSCs. Efficient in vitro differentiation of human cardiomyocytes is becoming a standard technique and hESC derived cardiomyocytes are beginning to be used in cardiotoxicity screens. In order to capitalise on these advances in cardiomyocyte generation and ensure the transfer of this technology into biopharmaceutical and clinical settings, enriched and well defined cell populations are required. Therefore, cell surface markers that allow the facile purification of cardiac cell lineages are needed. This work investigates the potential of two novel cell surface markers, SIRPA and VCAM1, in isolating enriched populations of committed human cardiomyocytes. The NKX2-5GFP/w reporter line was used to characterise the temporal expression, gene expression profiles and functional properties of SIRPA and VCAM1 cell populations that are found during cardiac differentiation. We demonstrate that fully functional cardiomyocytes arise from an NKX2-5+SIRPA+ intermediate which up regulates VCAM1 concomitantly with commitment to the myogenic lineages of the heart (ie. smooth and cardiac muscle). Under the culture conditions used in this study, the NKX2-5+SIRPA+ population had a higher single cell clonogenic potential and displayed the capacity to give rise to both smooth muscle and cardiac clones. Furthermore, when cultured as re-aggregates the majority of NKX2-5+SIRPA+ cells progressed to a NKX2-5+SIRPA+VCAM1+ phenotype thus demonstrating lineage relationship of these two cell populations. The identification of these cell surface markers provide a means for further study of linage specification during in vitro human cardiogenesis and will facilitate the development of technologies to produce well-characterised, purified human cardiomyocytes.
143O High anus preservation and low toxicity rates in a phase I trial of neoadjuvant bowel-sparing IMRT/bevacizumab/FOLFOX and TME for locally advanced rectal cancer
Authors: J.C.-H. Cheng, J.-T. Liang, C.-L. Tsai, J.-S. Hung, J. Huang, Y.-L. Lin, C.-C. Wang
Journal: Annals of Oncology (2015)
Brain injury during venovenous extracorporeal membrane oxygenation
Authors: Charles-Edouard Luyt, Nicolas Bréchot, Pierre Demondion, Tamara Jovanovic, Guillaume Hékimian, Guillaume Lebreton, Ania Nieszkowska, Matthieu Schmidt, Jean-Louis Trouillet, Pascal Leprince, Jean Chastre, Alain Combes
Journal: Intensive Care Medicine (2016)
Onset of obsessive-compulsive disorder in pregnancy
Authors: F Neziroglu, R Anemone, J A Yaryura-Tobias
Journal: American Journal of Psychiatry (1992)

Although the role of pregnancy and childbirth in postpartum psychosis and depression has been studied, the association between pregnancy and obsessive-compulsive disorder has not been specifically addressed. The authors evaluated the role of pregnancy in the onset of obsessive-compulsive disorder.Female patients with obsessive-compulsive disorder (N = 106) completed a questionnaire assessing age at onset of symptoms, marital status, number of children, age at each pregnancy, and life events associated with the onset of obsessive-compulsive disorder.Of the 106 women, 42 were childless and 59 had at least one child each; five others were also childless but had had abortions (N = 4) or a miscarriage (N = 1). Of the 42 women without children, 12 (28.6%) had first experienced obsessive-compulsive symptoms between the ages of 13 and 15 years, but there were two peaks of onset for the women with children: ages 22-24 and 29-32 years. Of the 59 patients with children, 23 (39.0%) had experienced symptom onset during pregnancy; this was the first pregnancy for 12, the second pregnancy for eight, and the third pregnancy for three. Four of the five women who had had abortions or a miscarriage had experienced the onset or an exacerbation of obsessive-compulsive symptoms during pregnancy.The association between pregnancy and the onset of obsessive-compulsive symptoms in these female patients highlights the need for further research on psychological and biological factors associated with pregnancy and obsessive-compulsive disorder.
Abstract 20219: Foxc2 Plays a Key Role in the Early Response to Cardiac Ischemia via Regulation of Cardiomyocyte Apoptosis
Authors: William H Dietz, Kyoo Shim, Hyun-Young Koo, Ting Liu, Christine Kamide, Tsutomu Kume
Journal: Circulation (2014)

Introduction: We have previously shown that forkhead box transcription factor C2 (Foxc2) plays a crucial role in angiogenesis. While Foxc2 has been implicated in cardiovascular disease, its role in the adult heart under pathological conditions and its underlying mechanism remain poorly understood. Hypothesis: We hypothesized that, in response to ischemic injury, Foxc2 acts through a cell-type-specific regulation of apoptosis. Methods: To test this hypothesis, mice heterozygous for either the Foxc2 global knockout (Foxc2+/-) or endothelial specific knockout (EC-Foxc2+/-), along with litter-mate controls, were subjected to myocardial infarction (MI) followed by echocardiographic analysis or whole-heart perfusion and harvest at baseline, or days 1, 3, 7, 14, or 28 post-MI. Hearts were then processed for histological staining, digested for flow cytometry, or further dissected for expression analysis. Results/ Conclusion: Time-course analysis of wild-type mice following MI revealed elevated border-zone Foxc2 mRNA 1 day post-MI, peaking at 3 days, and remaining highly elevated through day 7. Global Foxc2+/- mice subjected to ischemic injury displayed increased fibrotic scar tissue and impairment of cardiac function growing more significant with time, while EC-Foxc2+/- mice showed no change as measured by echocardiography and Masson’s Trichrome stain. Dual staining of TUNEL and lectin revealed increased border-zone apoptosis in global Foxc2+/- mice but no change in neovascularization. Analytical flow cytometry showed no difference in endothelial-specific apoptosis or cardiac leukocyte recruitment in global Foxc2+/- mice. Investigation of day 3 border-zone mRNA levels showed up-regulation of several pro-apoptotic genes including p53 and caspase3 in global Foxc2+/- hearts. Additionally, TUNEL and desmin co-staining confirmed a significant increase in cardiomyocyte-specific apoptosis 3 days post-MI. Our findings document that, in the early response to ischemic insult, Foxc2 acts through regulation of cardiomyocyte survival but not regulation of endothelial cell survival or leukocyte recruitment. Further investigation is warranted to elucidate the exact link between the protective effects of Foxc2 and cardiomyocyte survival.
Responses of Infant Rhesus Monkeys to Inoculation With Mason-Pfizer Monkey Virus Materials&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: D L Fine, J C Landon, R J Pienta, M T Kubicek, M G Valerio, W F Loeb, H C Chopra
Journal: JNCI Journal of the National Cancer Institute (1975)

Rhesus monkeys neonatally inoculated with Mason-Pfizer monkey virus (M-PMV) and virus-infected cells frequently developed viral and/or bacterial pneumonia and enteritis. Three characteristic hematologic patterns occurred among the inoculated animals and correlated well with the probability of survival. Postmortem examination of the animals revealed lymphadenopathy and thymic atrophy. M-PMV was present in lymph nodes, blood, brain, spleen, thymus, kidneys, and bone marrow. The disease induced in some animals had characteristics suggestive of a slow-virus-induced autoimmune response.
Endoscopic ultrasound-guided esophagoenterostomy for a completely obstructed surgical anastomosis
Authors: Gabriele Delconte, Andrea Mancini, Frank Vleggaar, Monica Salvetti, Vincenzo Mazzaferro, Enzo Masci
Journal: Endoscopy (2016)

Endoscopic ultrasound (EUS) has the potential to safely guide the creation of gastrointestinal anastomoses [1]. Different methods have been studied in animal models [2] and more recently EUS-guided gastroenterostomy with a lumen-apposing stent has been described in two small patient series [3] [4].
The Foundations' Fund for Research in Psychiatry and the growth of research in psychiatry
Authors: M Pines
Journal: American Journal of Psychiatry (1983)

For over a quarter century, until it disbursed its remaining funds in 1981, the Foundations' Fund for Research in Psychiatry (FFRP) aided hundreds of researchers in fields related to mental health. The fund was established by a private donor, the late Charles B. G. Murphy. Much of the research it sponsored during its early years was psychoanalytically oriented. In the 1960s it shifted to a more biological and social orientation. Its influence was greatest during its first decade, when its research grants, fellowships, and support to departments of psychiatry helped to launch the modern era of psychiatric research. This review analyzes FFRP's activities and examines its achievements.
Characteristics and prognosis of pneumococcal endocarditis: a case–control study
Authors: M. Daudin, P. Tattevin, B. Lelong, E. Flecher, S. Lavoué, C. Piau, A. Ingels, A. Chapron, J.-C. Daubert, M. Revest
Journal: Clinical Microbiology and Infection (2016)
Primitive Embryonic Macrophages are Required for Coronary Development and Maturation
Authors: Jamison Leid, Joana Carrelha, Hanane Boukarabila, Slava Epelman, Sten E.W. Jacobsen, Kory J. Lavine
Journal: Circulation Research (2016)

Rationale: It is now recognized that macrophages residing within developing and adult tissues are derived from diverse progenitors including those of embryonic origin. Although the functions of macrophages in adult organisms are well studied, the functions of macrophages during organ development remain largely undefined. Moreover, it is unclear whether distinct macrophage lineages have differing functions. Objective: To address these issues, we investigated the functions of macrophage subsets resident within the developing heart, an organ replete with embryonic-derived macrophages. Methods and Results: Using a combination of flow cytometry, immunostaining, and genetic lineage tracing, we demonstrate that the developing heart contains a complex array of embryonic macrophage subsets that can be divided into chemokine (C-C motif) receptor 2 − and chemokine (C-C motif) receptor 2 + macrophages derived from primitive yolk sac, recombination activating gene 1 + lymphomyeloid, and Fms-like tyrosine kinase 3 + fetal monocyte lineages. Functionally, yolk sac–derived chemokine (C-C motif) receptor 2 − macrophages are instrumental in coronary development where they are required for remodeling of the primitive coronary plexus. Mechanistically, chemokine (C-C motif) receptor 2 − macrophages are recruited to coronary blood vessels at the onset of coronary perfusion where they mediate coronary plexus remodeling through selective expansion of perfused vasculature. We further demonstrate that insulin like growth factor signaling may mediate the proangiogenic properties of embryonic-derived macrophages. Conclusions: Together, these findings demonstrate that the embryonic heart contains distinct lineages of embryonic macrophages with unique functions and reveal a novel mechanism that governs coronary development.
To marry or not to marry: a choice
Authors: C C Nadelson, M T Notman
Journal: American Journal of Psychiatry (1981)

The authors discuss the reasons for decisions to remain single or to marry, particularly for women today. They consider aspects of the life experience of single women and provide a developmental context for women's choices. The authors discuss the impact of marriage on women's lives and point out that marriage increases stress for women. The changing role of women in society and increased reproductive control have given women greater choice about the direction of their lives, including more freedom to make deliberate decisions about marriage.
Abstract 11340: Overexpression Myocardial Inducible Nitric Oxide Synthase (iNOS) Exacerbates Cardiac Dysfunction and Beta-Adrenergic Desensitization in Rats with Experimental Hypothyroidism
Authors: Qun Shao, Heng-Jie Cheng, Michael F Callahan, Wei-Min Li, Che Ping Cheng
Journal: Circulation (2012)

Background. Nitric oxide (NO) has been implicated in the pathophysiology of heart failure (HF). The significance and functional role of different NO synthase isoforms in this pathology are controve...
Outcomes with Cisplatin-Based First-Line Therapy for Advanced Urothelial Carcinoma (Uc) Following Previous Perioperative Cisplatin-Based Therapy
Authors: G. Sonpavde, A. Necchi, P. Giannatempo, G. Di Lorenzo, B.J. Eigl, J. Locke, S. Pal, N. Agarwal, A. Poole, U.N. Vaishampayan, G. Niegisch, S. Hussain, P. Singh, J. Bellmunt, G.R. Pond
Journal: Annals of Oncology (2014)
Drug points: Lethargy with omeprazole
Authors: E J M Meeuwisse, F C Groen, A Dees, G H Smit, J P Ottervanger
Journal: BMJ (1997)

We report a case of serious mental changes after omeprazole use in an otherwise healthy man. Rechallenge with the drug produced the same symptoms.

A 64 year old former security officer presented with symptoms of reflux disease. After endoscopy he was treated with omeprazole 40 mg daily for Barrett's oesophagitis. He was in excellent physical and mental health and was taking no other drugs. He was a non-smoker and drank alcohol only occasionally; …