tbuckley/cabot-search huggingface dataset:
Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial
Authors: M. Bhushan, T.O. Bleiker, A.E. Ballsdon, M.H. Allen, M. Sopwith, M.K. Robinson, C. Clarke, R.P.J.B. Weller, R.A.C. Graham-Brown, M. Keefe, J.N.W.N. Barker, C.E.M. Griffiths
Journal: British Journal of Dermatology (2002)

Journal Article Anti‐E‐selectin is ineffective in the treatment of psoriasis: a randomized trial Get access M. Bhushan, M. Bhushan The Dermatology Centre, Irving Building, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, U.K Search for other works by this author on: Oxford Academic Google Scholar T.O. Bleiker, T.O. Bleiker Department of Dermatology, Leicester Royal Infirmary, Leicester, LE1 5WW, U.K Search for other works by this author on: Oxford Academic Google Scholar A.E. Ballsdon, A.E. Ballsdon St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K Search for other works by this author on: Oxford Academic Google Scholar M.H. Allen, M.H. Allen St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K Search for other works by this author on: Oxford Academic Google Scholar M. Sopwith, M. Sopwith Celltech R&D Ltd, 216 Bath Road, Slough, Berkshire, SL1 4EN, U.K Search for other works by this author on: Oxford Academic Google Scholar M.K. Robinson, M.K. Robinson Celltech R&D Ltd, 216 Bath Road, Slough, Berkshire, SL1 4EN, U.K Search for other works by this author on: Oxford Academic Google Scholar C. Clarke, C. Clarke Medeval, Skelton House, Manchester Science Park, Lloyd Street North, Manchester M15 6SH, U.K Search for other works by this author on: Oxford Academic Google Scholar R.P.J.B. Weller, R.P.J.B. Weller Department of Dermatology, The Royal Infirmary of Edinburgh, Edinburgh, EH3 9YW, U.K Search for other works by this author on: Oxford Academic Google Scholar R.A.C. Graham‐Brown, R.A.C. Graham‐Brown Department of Dermatology, Leicester Royal Infirmary, Leicester, LE1 5WW, U.K Search for other works by this author on: Oxford Academic Google Scholar M. Keefe, M. Keefe Department of Dermatology, Royal South Hants Hospital, Southampton, SO14 0YG, U.K Search for other works by this author on: Oxford Academic Google Scholar ... Show more J.N.W.N. Barker, J.N.W.N. Barker St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K Search for other works by this author on: Oxford Academic Google Scholar C.E.M. Griffiths C.E.M. Griffiths The Dermatology Centre, Irving Building, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, U.K Professor C.E.M.Griffiths. E‐mail: christopher.griffiths@man.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 5, 1 May 2002, Pages 824–831, https://doi.org/10.1046/j.1365-2133.2002.04743.x Published: 01 May 2002 Article history Accepted: 12 December 2001 Published: 01 May 2002
Antirestenotic Effects of a Locally Delivered Caspase Inhibitor in a Balloon Injury Model
Authors: Nirat Beohar, James D. Flaherty, Charles J. Davidson, Robert C. Maynard, Joel D. Robbins, Atman P. Shah, James W. Choi, Lee A. MacDonald, Jesse P. Jorgensen, Jack V. Pinto, Sonal Chandra, Heather M. Klaus, Norman C. Wang, Kathleen R. Harris, Robert Decker, Robert O. Bonow
Journal: Circulation (2003)

The precise role of arterial barotrauma-mediated apoptosis in causing restenosis is unclear. The purpose of this study was to determine if a link exists between angioplasty-mediated medial smooth muscle cell apoptosis and subsequent neointimal hyperplasia.Bilateral iliac artery angioplasty was performed in 25 male New Zealand White rabbits. Simultaneous with balloon injury, each artery was treated locally with either the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(Ome)-fluoromethylketone (ZVAD-fmk) or control. In the acute cohort that was survived to 4 hours (n=10, 7 high dose and 3 low dose), an apoptotic index was calculated using the terminal deoxynucleotidyl TUNEL method. In the intermediate cohort that was survived to 2 weeks (n=5), luminal reendothelialization was measured via CD-31 staining. In the chronic cohort that was survived to 4 weeks (n=10), neointimal area was measured. In the acute cohort, there was a 40% reduction in the apoptotic index with high-dose ZVAD-fmk (P=0.008) and a 33% reduction with low-dose ZVAD-fmk (P=0.08). At 2 weeks, there was no significant difference in the degree of luminal reendothelialization. However, at 4 weeks, there was a 33% (0.33+/-0.23 versus 0.22+/-0.20 mm2) (P<0.005) reduction in neointimal area in ZVAD-fmk-treated arteries.The local delivery of ZVAD-fmk during balloon injury inhibits smooth muscle cell apoptosis. This corresponds to a significant reduction in neointimal proliferation seen at 4 weeks without a significant change in the degree of reendothelialization at 2 weeks.
Reduced Concentrations of Thalamic N-Acetylaspartate in Male Patients With Schizophrenia
Authors: Raymond F. Deicken, Camilla Johnson, Yael Eliaz, Norbert Schuff
Journal: American Journal of Psychiatry (2000)

OBJECTIVE: The authors measured N-acetylaspartate (a putative neuronal marker) in the right and left thalamus of 17 male patients with schizophrenia using in vivo proton magnetic resonance spectroscopic imaging (1H MRSI). METHOD: 1H MRSI was performed on 17 medicated male patients with schizophrenia and 10 male comparison subjects. Concentrations of N-acetylaspartate, creatine, and choline were determined in the thalamic regions bilaterally. RESULTS: The patients with schizophrenia demonstrated significantly lower concentrations of N-acetylaspartate than the comparison subjects in both the right and left thalamic regions. Right thalamic N-acetylaspartate and left thalamic N-acetylaspartate were significantly correlated in the patients but not in the comparison subjects. There was no association between N-acetylaspartate and duration of illness or medication dose. No group differences or lateralized asymmetries in choline or creatine were noted. CONCLUSIONS: The finding of reduced concentrations of N-acetylaspartate bilaterally suggests neuronal dysfunction and/or loss in both the right and left thalamic regions in male patients with schizophrenia.
Longitudinal Effects of MRI-Measured Hepatic Steatosis on Biomarkers of Glucose Homeostasis and Hepatic Apoptosis in Obese Youth
Authors: Grace Kim, Cosimo Giannini, Bridget Pierpont, Ariel E. Feldstein, Nicola Santoro, Romy Kursawe, Melissa Shaw, Elvira Duran, Rachel Goldberg, James Dziura, Sonia Caprio
Journal: Diabetes Care (2012)

We used fast-gradient magnetic resonance imaging (MRI) to determine the longitudinal associations between the hepatic fat content (HFF), glucose homeostasis, and a biomarker of hepatocellular apoptosis in obese youth.Baseline and longitudinal liver and abdominal MRI were performed with an oral glucose tolerance test in 76 obese youth followed for an average of 1.9 years. Cytokeratin-18 (CK-18) was measured at baseline and follow-up as a biomarker of hepatic apoptosis. The relationship between baseline HFF and metabolic parameters and circulating levels of CK-18 at follow-up were assessed using a bivariate correlation.At baseline, 38% had hepatic steatosis based on %HFF ≥5.5% with alterations in indices of insulin sensitivity and secretion. At follow-up, BMI increased in both groups and baseline %HFF correlated strongly with the follow-up %HFF (r = 0.81, P < 0.001). Over time, markers of insulin sensitivity and 2-h glucose improved significantly in the group without fatty liver, in contrast with the persistence of the insulin resistance and associated correlates in the fatty liver group. Baseline HFF correlated with 2-h glucose (r = 0.38, P = 0.001), whole-body insulin sensitivity (r = -0.405, P = 0.001), adiponectin (r = -0.44, P < 0.001), CK-18 levels, (r = 0.63, P < 0.001), and disposition index (r = -0.272, P = 0.021) at follow-up. In a multivariate analysis, we showed that baseline HFF is an independent predictor of 2-h glucose and whole-body insulin sensitivity.In obese youth, the phenotype of MRI-measured hepatic steatosis is persistent. Baseline HFF strongly modulates longitudinally 2-h blood glucose, biomarkers of insulin resistance, and hepatocellular apoptosis.
Patient non-compliance with paper diaries
Authors: A. A Stone
Journal: BMJ (2002)

Doctors often ask patients to recall recent health experiences, such as pain, fatigue, and quality of life. 1 Research has shown, however, that recall is unreliable and rife with inaccuracies and biases. 2 Recognition of recall's shortcomings has led to the use of diaries, which are intended to capture experiences close to the time of occurrence, thus limiting recall bias and producing more accurate data. 3 The rationale for using diaries would be undermined if patients failed to complete diaries according to protocol.In this study we used a newly developed paper diary that could objectively record when patients made diary entries in order to compare patients' reported and actual compliance with diary keeping.For comparison, we also used an electronic diary designed to enhance compliance in order to assess what compliance rates might be achieved.
Comparative study of intra-articular pressure dynamics in joints with acute traumatic and chronic inflammatory effusions: potential implications for hypoxic-reperfusion injury.
Authors: P Merry, R Williams, N Cox, J B King, D R Blake
Journal: Annals of the Rheumatic Diseases (1991)

It has been proposed that the process of hypoxic-reperfusion injury contributes to the persistence of synovitis in the inflamed human joint. The generation of pathological, exercise induced, intra-articular pressure leading to occlusion of the synovial microcirculation is central to this mechanism. However, acute traumatic inflammatory joint effusions rarely result in chronic synovitis, suggesting that either the basic hypothesis is incorrect, or that joints with acute traumatic effusions show different intra-articular pressure dynamics. In this study the intra-articular pressure was measured at rest and during isometric exercise in five patients with acute traumatic joint effusions and in nine patients with chronic inflammatory joint effusions. The generation of intra-articular pressure in the patients with acute traumatic effusions was significantly lower at rest (mean 2.0 v 19.6 mm Hg) and during exercise (mean 13.7 v 222.5 mm Hg) than in the patients with chronic effusions. This was due to reflex muscular inhibition around the joint, which inhibited the pathological generation of intra-articular pressure. This difference in the ability to generate intra-articular pressure might mitigate against hypoxic-reperfusion injury in joints with acute traumatic effusions, thereby explaining the paradoxical clinical observation that patients with acute traumatic inflammatory joint effusions rarely develop chronic synovitis.
Population-Based Study of Relationships Between Hospital Volume of Prostatectomies, Patient Outcomes, and Length of Hospital Stay
Authors: S.-L. Yao, G. Lu-Yao
Journal: JNCI Journal of the National Cancer Institute (1999)

Despite the large number of prostatectomies performed annually, few data exist regarding relationships between the volume of prostatectomies handled by a hospital, the length of a patient's stay in the hospital, and patient outcomes. We examined the effect of hospital prostatectomy volume and changes in the hospital volume on patient outcomes and the length of a patient's stay.We collected data on 101 604 prostatectomies from Medicare claims filed from 1991 through 1994. By use of logistic regression and analysis of variance, we examined relationships between hospital load of prostatectomies, length of a patient's hospital stay, surgical complications, readmission rate, and mortality rate in a 30-day period following surgery. Statistical tests were two-sided.Cross-sectional analyses revealed that, compared with high-volume hospitals, low-volume, medium-low-volume, and medium-high-volume hospitals had higher relative risks of readmission by 30% (95% confidence interval [CI] = 21%-39%), 16% (95% CI = 7%-25%), and 8% (95% CI = -1% to 17%), respectively; higher relative risks of serious complications by 43% (95% CI = 37%-48%), 25% (95% CI = 19%-31%), and 9% (95% CI = 3%-15%), respectively; and higher relative risks of mortality by 51% (95% CI = 25%-77%), 43% (95% CI = 17%-69%), and 42% (95% CI = 16%-68%), respectively. The mean length of a patient's stay in a low-volume hospital was 9% longer than that in a high-volume hospital (8.51 days [95% CI = 8.47-8.56] versus 7.81 days [95% CI = 7.77-7.85]; P for trend across all volume categories =.0001). Within-hospital longitudinal analyses revealed that hospitals with a relative increase in prostatectomy volume had a 57% greater reduction in the length of a patient's stay compared with those with a relative decrease in volume (P =.005). Changes in prostatectomy volume did not affect the frequency of complications, mortality, and readmission. These findings suggest that an increase in a given hospital's prostatectomy volume may facilitate a decrease in the length of a patient's stay without an adverse impact on patient outcomes.
A Randomized, Double-Blind, Dose-Finding, Multicenter, Phase 2 Study of Radium Chloride (Ra 223) in Patients with Bone Metastases and Castration-Resistant Prostate Cancer
Authors: Christopher C. Parker, Sarah Pascoe, Aleš Chodacki, Joe M. O'Sullivan, Josep R. Germá, Charles Gillies O’Bryan-Tear, Trond Haider, Peter Hoskin
Journal: European Urology (2012)
CLINICAL USE OF A.F.P. AND H.C.G. IN TESTICULAR TUMOURS OF GERM-CELL ORIGIN
Authors: Bent Nørgaard-Pedersen, R. Albrechtsen, K.D. Bagshawe, D. Buffe, Y. Endo, E. Heyderman, H. Hirai, C.H. Horne, I. Hägerstrand, N. Javadpour, J.B. Knudsen, J. Kohn, R. Lamerz, P.H. Lange, K.R. Mcintire, A. Munro Neville, K. Nustad, M.J. Peckham, J.G. Ratcliffe, C. Rimbaut, S. Rosen, S. Sakashita, P.T. Scardino, H. Schultz, M. Seppäla, PH. Sizaret, A. Talerman, D.K. Thompson, J. Tsuchida, J. Vaitukaitis, B. Wahren, T.A. Waldmann
Journal: The Lancet (1978)
Physical Activity and Public Health
Authors: William L. Haskell, I-Min Lee, Russell R. Pate, Kenneth E. Powell, Steven N. Blair, Barry A. Franklin, Caroline A. Macera, Gregory W. Heath, Paul D. Thompson, Adrian Bauman
Journal: Circulation (2007)

In 1995 the American College of Sports Medicine and the Centers for Disease Control and Prevention published national guidelines on Physical Activity and Public Health. The Committee on Exercise and Cardiac Rehabilitation of the American Heart Association endorsed and supported these recommendations. The purpose of the present report is to update and clarify the 1995 recommendations on the types and amounts of physical activity needed by healthy adults to improve and maintain health. Development of this document was by an expert panel of scientists, including physicians, epidemiologists, exercise scientists, and public health specialists. This panel reviewed advances in pertinent physiologic, epidemiologic, and clinical scientific data, including primary research articles and reviews published since the original recommendation was issued in 1995. Issues considered by the panel included new scientific evidence relating physical activity to health, physical activity recommendations by various organizations in the interim, and communications issues. Key points related to updating the physical activity recommendation were outlined and writing groups were formed. A draft manuscript was prepared and circulated for review to the expert panel as well as to outside experts. Comments were integrated into the final recommendation.To promote and maintain health, all healthy adults aged 18 to 65 yr need moderate-intensity aerobic (endurance) physical activity for a minimum of 30 min on five days each week or vigorous-intensity aerobic physical activity for a minimum of 20 min on three days each week. [I (A)] Combinations of moderate- and vigorous-intensity activity can be performed to meet this recommendation. [IIa (B)] For example, a person can meet the recommendation by walking briskly for 30 min twice during the week and then jogging for 20 min on two other days. Moderate-intensity aerobic activity, which is generally equivalent to a brisk walk and noticeably accelerates the heart rate, can be accumulated toward the 30-min minimum by performing bouts each lasting 10 or more minutes. [I (B)] Vigorous-intensity activity is exemplified by jogging, and causes rapid breathing and a substantial increase in heart rate. In addition, every adult should perform activities that maintain or increase muscular strength and endurance a minimum of two days each week. [IIa (A)] Because of the dose-response relation between physical activity and health, persons who wish to further improve their personal fitness, reduce their risk for chronic diseases and disabilities or prevent unhealthy weight gain may benefit by exceeding the minimum recommended amounts of physical activity. [I (A)]
Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine.
Authors: D C Whitcomb, F R Gilliam, C F Starmer, A O Grant
Journal: Journal of Clinical Investigation (1989)

The opiate analgesic propoxyphene produces cardiac toxicity when taken in overdose. We recently observed a patient with propoxyphene overdose in whom marked QRS widening was reversed by lidocaine. The reversal is apparently paradoxical as both agents block the inward sodium current (INa). We examined possible mechanisms of the reversal by measuring INa in rabbit atrial myocytes during exposure to propoxyphene and the combination of propoxyphene and lidocaine (60 and 80 microM, respectively). Propoxyphene caused use-dependent block of INa during pulse train stimulation. Block recovered slowly with time constants of 20.8 +/- 3.9 s. Block during lidocaine exposure recovered with time constants of 2-3 s. During exposure to the mixture, block recovered as a double exponential. The half time for recovery during exposure to the mixture was 1.6 +/- .9 s compared with a half-time of 14.3 +/- 2.9 s during exposure to propoxyphene alone. During pulse train stimulation, less steady-state block was observed during exposure to the mixture than during exposure to propoxyphene alone when the interval between pulses was greater than 0.95 s. Both drugs compete for a common receptor during the polarizing phase. The more rapid dissociation of lidocaine during the recovery period leads to less block during the mixture than during exposure to propoxyphene alone. The experiments suggest a mechanism for reversal of the cardiac toxicity of drugs which have slow unbinding kinetics.
Cell Therapy for Lung Diseases. Report from an NIH–NHLBI Workshop, November 13–14, 2012
Authors: Michael A. Matthay, Piero Anversa, Jahar Bhattacharya, Bruce K. Burnett, Harold A. Chapman, Joshua M. Hare, Derek J. Hei, Andrew M. Hoffman, Stella Kourembanas, David H. McKenna, Luis A. Ortiz, Harald C. Ott, William Tente, Bernard Thébaud, Bruce C. Trapnell, Daniel J. Weiss, Jason X.-J. Yuan, Carol J. Blaisdell
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health convened the Cell Therapy for Lung Disease Working Group on November 13-14, 2012, to review and formulate recommendations for future research directions. The workshop brought together investigators studying basic mechanisms and the roles of cell therapy in preclinical models of lung injury and pulmonary vascular disease, with clinical trial experts in cell therapy for cardiovascular diseases and experts from the NHLBI Production Assistance for Cell Therapy program. The purpose of the workshop was to discuss the current status of basic investigations in lung cell therapy, to identify some of the scientific gaps in current knowledge regarding the potential roles and mechanisms of cell therapy in the treatment of lung diseases, and to develop recommendations to the NHLBI and the research community on scientific priorities and practical steps that would lead to first-in-human trials of lung cell therapy.
Cytokine-Induced Src Homology 2 Protein (Cis) Promotes T Cell Receptor–Mediated Proliferation and Prolongs Survival of Activated T Cells
Authors: Suling Li, Shangwu Chen, Xiufeng Xu, Anette Sundstedt, Kajsa M. Paulsson, Per Anderson, Stefan Karlsson, Hans-Olov Sjögren, Ping Wang
Journal: The Journal of Experimental Medicine (2000)

Members of the suppressor of cytokine signaling (SOCS) family were discovered as negative regulators of cytokine signaling by inhibition of the Janus kinase–signal transducer and activator of transcription (Jak-STAT) pathway. Among them, cytokine-induced Src homology 2 (SH2) protein (CIS) was found to inhibit the interleukin 3– and erythropietin-mediated STAT5 signaling pathway. However, involvement of SOCS proteins in other signaling pathways is still unknown. This study shows that the expression of CIS is selectively induced in T cells after T cell receptor (TCR) stimulation. In transgenic mice, with selective expression of CIS in CD4 T cells, elevated CIS strongly promotes TCR-mediated proliferation and cytokine production in vitro, and superantigen-induced T cell activation in vivo. Forced expression of CIS also prolongs survival of CD4 T cells after TCR activation. Molecular events immediately downstream from the TCR are not changed in CIS-expressing CD4 T cells, but activation of mitogen-activated protein (MAP) kinase pathways by TCR stimulation is significantly enhanced. Together with the increased MAP kinase activation, a direct interaction of CIS and protein kinase Cθ was also demonstrated. These results suggest that CIS is one of the important regulators of TCR-mediated T cell activation. The functions of CIS, enhancing TCR signaling and inhibiting cytokine signaling, may be important in the regulation of immune response and homeostasis.
EXCRETION OF SILVER IN URINE
Authors: Joseph C. Aub
Journal: JAMA (1942)

<h3>To the Editor:—</h3> We have just read the communication by Dr. Victor Jacobson inThe Journalof Nov. 1, 1941, page 1557. It may be of interest that one of our unpublished observations confirm his point of view that silver is not excreted in the urine. Some years ago we studied a case of obvious argyria, and we tried by the technics which we had used in cases of lead poisoning to withdraw the silver from its depots in the body. In spite of a prolonged investigation, with fairly heavy deleading treatment, no measurable amount of silver was ever found in the urine. From this we decided that lead and silver differed greatly in their metabolic responses in the body.