tbuckley/cabot-search huggingface dataset:
CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice
Authors: Flavia E. Pereira, Chunxia Cronin, Mallika Ghosh, Si-Yuan Zhou, Mariela Agosto, Jaganathan Subramani, Ruibo Wang, Jian-Bing Shen, Wolfgang Schacke, Brannen Liang, Tie Hong Yang, Beata McAulliffe, Bruce T. Liang, Linda H. Shapiro
Journal: Cardiovascular Research (2013)

To determine the role of CD13 as an adhesion molecule in trafficking of inflammatory cells to the site of injury in vivo and its function in wound healing following myocardial infarction induced by permanent coronary artery occlusion.Seven days post-permanent ligation, hearts from CD13 knockout (CD13(KO)) mice showed significant reductions in cardiac function, suggesting impaired healing in the absence of CD13. Mechanistically, CD13(KO) infarcts showed an increase in small, endothelial-lined luminal structures, but no increase in perfusion, arguing against an angiogenic defect in the absence of CD13. Cardiac myocytes of CD13(KO) mice showed normal basal contractile function, eliminating myocyte dysfunction as a mechanism of adverse remodelling. Conversely, immunohistochemical and flow cytometric analysis of CD13(KO) infarcts demonstrated a dramatic 65% reduction in infiltrating haematopoietic cells, including monocytes, macrophages, dendritic, and T cells, suggesting a critical role for CD13 adhesion in inflammatory trafficking. Accordingly, CD13(KO) infarcts also contained fewer myofibroblasts, consistent with attenuation of fibroblast differentiation resulting from the reduced inflammation, leading to adverse remodelling.In the ischaemic heart, while compensatory mechanisms apparently relieve potential angiogenic defects, CD13 is essential for proper trafficking of the inflammatory cells necessary to prime and sustain the reparative response, thus promoting optimal post-infarction healing.
TCT-774 Circulatory Support is Associated with Higher Mortality During TAVR
Authors: Satya S. Shreenivas, Scott M. Lilly, Wilson Y. Szeto, Nimesh Desai, Saif Anwaruddin, Joseph E. Bavaria, Vinod Thourani, Raj Makkar, Augusto Pichard, Webb John, Todd Dewey, Samir Kapadia, Ke Xu, Martin Leon, Howard C. Herrmann
Journal: Journal of the American College of Cardiology (2013)
Familial Pathways to Early-Onset Suicidal Behavior: Familial and Individual Antecedents of Suicidal Behavior
Authors: Nadine M Melhem, David A Brent, Melissa Ziegler, Satish Iyengar, David Kolko, Maria Oquendo, Boris Birmaher, Ainsley Burke, Jamie Zelazny, Barbara Stanley, J John Mann
Journal: American Journal of Psychiatry (2007)

The authors sought to identify clinical predictors of new-onset suicidal behavior in children of parents with a history of mood disorder and suicidal behavior.In a prospective study of offspring of parents with mood disorders, 365 offspring (average age, 20 years) of 203 parents were followed for up to 6 years. Offspring with incident suicide attempts or emergency referrals for suicidal ideation or behavior ("incident events") were compared with offspring without such events on demographic and clinical characteristics. Multivariate analyses were conducted to examine predictors of incident events and predictors of time to incident event.Offspring of probands who had made suicide attempts, compared with offspring of parents with mood disorders who had not made attempts, had a higher rate of incident suicide attempts (4.1% versus 0.6%, relative risk=6.5) as well as overall suicidal events (8.3% versus 1.9%, relative risk=4.4). Mood disorder and self-reported impulsive aggression in offspring and a history of sexual abuse and self-reported depression in parents predicted earlier time to, and greater hazard of, an incident suicidal event.In offspring of parents with mood disorders, precursors of early-onset suicidal behavior include mood disorder and impulsive aggression as well as parental history of suicide attempt, sexual abuse, and self-reported depression. These results suggest that efforts to prevent the familial transmission of early-onset suicidal behavior by targeting these domains could reduce the morbidity of suicidal behavior in high-risk youths.
Colorectal cancer prognosis: is it all mutation, mutation, mutation?
Authors: A B Hassan
Journal: Gut (2005)

For the 500 000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts. K-ras, but not p53 or APC, mutations appear to be associated with poorer overall survival in colorectal cancer patients.
Long-Term Use of Anticoagulants in Private Practice
Authors: Martin H. Reinberg
Journal: JAMA (1965)

THE EFFICACY of anticoagulants in the treatment of myocardial infarction and in the postinfarction period is controversial.<sup>1</sup>However, it appears likely that such therapy will be used for some time. The risks of anticoagulant therapy are relatively small, as determined in many well-controlled studies.<sup>2 -4</sup>The most important risk is major hemorrhage, the incidence of which was found to be 1.5% to 10% in both short<sup>2,3</sup>and long-term<sup>4,5</sup>usage. Most of the studies have been done in large medical centers. There have been very few reports from private practice, where the incidence of serious hemorrhage may be different. Pastor et al have suggested<sup>5</sup>that the statistics in well-controlled studies may not reflect the true incidence of hemorrhage or fatality, since the practicing physicians who administer most of the anticoagulants do not have occasion to publish their results. One of the most important factors in determining
Atrial Fibrillation Originating From Persistent Left Superior Vena Cava
Authors: Li-Fern Hsu, Pierre Jaïs, David Keane, J. Marcus Wharton, Isabel Deisenhofer, Mélèze Hocini, Dipen C. Shah, Prashanthan Sanders, Christophe Scavée, Rukshen Weerasooriya, Jacques Clémenty, Michel Haïssaguerre
Journal: Circulation (2004)

The left superior vena cava (LSVC) is the embryological precursor of the ligament of Marshall, which has been implicated in the initiation and maintenance of atrial fibrillation (AF). Rarely, the LSVC may persist and has been associated with some organized arrhythmias, though not with AF. We report 5 patients in whom the LSVC was a source of ectopy, initiating AF.In 5 patients (4 men; age, 46+/-11 years) with symptomatic drug-refractory AF, ectopy from the LSVC resulting in AF was observed after pulmonary vein isolation. The ectopics were spontaneous in 2 and induced by isoproterenol in the others and preceded P-wave onset by 67+/-13 ms. During multielectrode or electroanatomic mapping, venous potentials were recorded circumferentially at the proximal LSVC near its junction with the coronary sinus (CS), but at the mid-LSVC level, they were recorded only on part of the circumference. The LSVC was electrically connected to the lateral left atrium (LA) and through the CS to the right atrium, with 4.1+/-2.3 CS-LSVC and 1.6+/-0.5 LA-LSVC connections per patient. Catheter ablation in the LSVC targeting these connections resulted in electrical isolation in 4 of the 5 patients without complications. After 15+/-10 months, the 4 patients with successful isolation, including 1 who had successful reablation for LA flutter, remained in sinus rhythm without drugs.The LSVC can be the arrhythmogenic source of AF with connections to the CS and LA. Ablation of these connections resulted in electrical isolation.
Sigma-1 Receptors Bind Cholesterol and Remodel Lipid Rafts in Breast Cancer Cell Lines
Authors: Christopher P. Palmer, Robert Mahen, Eva Schnell, Mustafa B.A. Djamgoz, Ebru Aydar
Journal: Cancer Research (2007)

Abstract Lipid rafts are membrane platforms that spatially organize molecules for specific signaling pathways that regulate various cellular functions. Cholesterol is critical for liquid-ordered raft formation by serving as a spacer between the hydrocarbon chains of sphingolipids, and alterations in the cholesterol contents of the plasma membrane causes disruption of rafts. The role that σ receptors play in cancer is not clear, although it is frequently up-regulated in human cancer cells and tissues and σ receptors inhibit proliferation in carcinoma and melanoma cell lines, induce apoptosis in colon and mammary carcinoma cell lines, and reduce cellular adhesion in mammary carcinoma cell lines. In this study, we provide molecular and functional evidence for the involvement of the enigmatic σ1 receptors in lipid raft modeling by σ1 receptor–mediated cholesterol alteration of lipid rafts in breast cancer cell lines. Cholesterol binds to cholesterol recognition domains in the COOH terminus of the σ1 receptor. This binding is blocked by σ receptor drugs because the cholesterol-binding domains form part of the σ receptor drug-binding site, mutations of which abolish cholesterol binding. Furthermore, we outline a hypothetical functional model to explain the myriad of biological processes, including cancer, in which these mysterious receptors are involved. The findings of this study provide a biological basis for the potential therapeutic applications of lipid raft cholesterol regulation in cancer therapy using σ receptor drugs. [Cancer Res 2007;67(23):11166–75]
Wood-cutter's Disease: Contact Sensitivity to Lichen.
Authors: R. H. Champion
Journal: British Journal of Dermatology (1965)

Journal Article Wood‐cutter's Disease: Contact Sensitivity to Lichen. Get access R. H. Champion R. H. Champion Cambridge Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 5, 1 May 1965, Page 285, https://doi.org/10.1111/j.1365-2133.1965.tb14646.x Published: 01 May 1965
<i>IDH1</i> and <i>IDH2</i> Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
Authors: Martin J. van den Bent, Hendrikus J. Dubbink, Yannick Marie, Alba A. Brandes, Martin J.B. Taphoorn, Pieter Wesseling, Marc Frenay, Cees C. Tijssen, Denis Lacombe, Ahmed Idbaih, Ronald van Marion, Johan M. Kros, Winand N.M. Dinjens, Thierry Gorlia, Marc Sanson
Journal: Clinical Cancer Research (2010)

Recent studies have shown the prognostic significance of IDH1 mutations in glioma. It is yet unclear if IDH1 mutations are predictive for outcome to chemotherapy. We determined the effect of IDH1 mutations on progression-free survival and overall survival (OS), and its correlation with other clinical and molecular features in the prospective randomized European Organization for Research and Treatment of Cancer study 26951 on adjuvant procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine (PCV) in anaplastic oligodendroglioma.IDH1 and IDH2 alterations of the mutational hotspot codons R132 and R172 were assessed by the bidirectional cycle sequencing of PCR-amplified fragments. MGMT promoter methylation was assessed using methylation-specific multiplex ligation-dependant probe amplification based on methylation-sensitive restriction analysis. Loss of chromosomes 1p, 19q, 10, and 10q and the gain of 7 and the EGFR gene were assessed with fluorescence in situ hybridization.From 159 patients, sufficient material was available for IDH1 analysis. In 151 and 118 of these patients, respectively, the 1p/19q status and the MGMT promoter methylation status were known. In 73 cases (46%), an IDH1 mutation was found and only one IDH2 mutation was identified. The presence of IDH1 mutations correlated with 1p/19q codeletion and MGMT promoter methylation, and inversely correlated with loss of chromosome 10, EGFR amplification, polysomy of chromosome 7, and the presence of necrosis. IDH1 mutations were found to be prognostic in the radiotherapy- and the radiotherapy/PCV-treated patients, for both progression-free survival and OS. With Cox proportional hazard modeling for OS with stepwise selection, IDH1 mutations and 1p/19q codeletion but not MGMT promoter methylation were independent prognostic factors.In this homogeneously treated group of anaplastic oligodendroglioma patients, the presence of IDH1 mutations was found to carry a very strong prognostic significance for OS but without evidence of a predictive significance for outcome to PCV chemotherapy. IDH1 mutations were strongly associated with 1p/19q codeletion and MGMT promoter methylation.
Peginterferon alfa-2b plus ribavirin treatment in children and adolescents with chronic hepatitis C
Authors: Stefan Wirth, Heidrun Pieper‐Boustani, Thomas Lang, Antje Ballauff, Ulrike Kullmer, Patrick Gerner, Philip Wintermeyer, Andreas Jenke
Journal: Hepatology (2005)

Peginterferon plus ribavirin is standard therapy for adults with chronic hepatitis C. As no data are available for children, the aim of the study was to evaluate the efficacy and tolerability of peginterferon alfa-2b in combination with ribavirin in chronically infected children. Genotypes, alanine aminotransferase levels, and different routes of viral transmission were considered. In an open-labeled, uncontrolled pilot study, 62 children and adolescents (range, 2-17 years) were treated with subcutaneous peginterferon alfa-2b at a dose of 1.5 microg/kg body weight once per week plus oral ribavirin (15 mg/kg x day) for 48 weeks. Sixty-one patients completed the study. Twenty-three children discontinued therapy after 6 months according to study protocol. Sustained viral response was documented in 22 (47.8%)of 46 patients with genotype 1, in 13 (100%) of 13 with genotype 2 or 3, in 1 of 2 with genotype 4, in 19 (70.4%) of 27 children with parenteral, in 12 (48%) of 25 with vertical, and in 5 of 9 with unknown route of infection. Overall, treatment was well tolerated. Nevertheless, some side effects were present in all treated patients. Eighty-three percent had leucopenia, but only 3 individuals required dose reduction and 10.3% developed thyroid autoantibodies and thyroid dysfunction. In conclusion, combination treatment of peginterferon alfa-2b with ribavirin showed encouraging results and was well tolerated in children and adolescents with chronic hepatitis C. Weekly dosing of peginterferon alfa-2b is a considerable advance for this age group. The treatment is not approved for children. Further controlled trials are needed.
Innate Lymphoid Cells Are the Predominant Source of IL-17A during the Early Pathogenesis of Acute Respiratory Distress Syndrome
Authors: Roshell Muir, Megan Osbourn, Alice V. Dubois, Emma Doran, Donna M. Small, Avril Monahan, Cecilia M. O’Kane, Katherine McAllister, Denise C. Fitzgerald, Adrien Kissenpfennig, Daniel F. McAuley, Rebecca J. Ingram
Journal: American Journal of Respiratory and Critical Care Medicine (2015)

Rationale: IL-17A is purported to help drive early pathogenesis in acute respiratory distress syndrome (ARDS) by enhancing neutrophil recruitment. Although IL-17A is the archetypal cytokine of T-helper 17 cells, it is produced by a number of lymphocytes, the source during ARDS being unknown.Objectives: To identify the cellular source and the role of IL-17A in the early phase of lung injury.Methods: Lung injury was induced in wild-type (C57BL/6) and IL-17 knockout (KO) mice with aerosolized LPS (100 μg) or Pseudomonas aeruginosa infection. Detailed phenotyping of the cells expressing RORγt, the transcriptional regulator of IL-17 production, in the mouse lung at 24 hours was performed by flow cytometry.Measurements and Main Results: A 100-fold reduction in neutrophil infiltration was observed in the lungs of the IL-17A KO compared with wild-type mice. The majority of RORγt+ cells in the mouse lung were the recently identified group 3 innate lymphoid cells (ILC3s). Detailed characterization revealed these pulmonary ILC3s (pILC3s) to be discrete from those described in the gut. The critical role of these cells was verified by inducing injury in recombinase-activating gene 2 KO mice, which lack T cells but retain innate lymphoid cells. No amelioration of pathology was observed in the recombinase-activating gene 2 KO mice.Conclusions: IL-17 is rapidly produced during lung injury and significantly contributes to early immunopathogenesis. This is orchestrated largely by a distinct population of pILC3s. Modulation of the activity of pILC3s may potentiate early control of the inflammatory dysregulation seen in ARDS, opening up new therapeutic targets.
The Relation of Immunoglobulin Class, Pattern of Antinuclear Antibody, and Complement-Fixing Antibodies to DNA in Sera from Patients with Systemic Lupus Erythematosus*
Authors: Naomi F. Rothfield, B. David Stollar
Journal: Journal of Clinical Investigation (1967)

Sera from 55 patients with systemic lupus erythematosus were studied to clarify the significance of the patterns of nuclear fluorescence observed. The sera in which the IgG fraction produced a peripheral pattern of nuclear fluorescence were found to contain complement-fixing antibodies to native DNA and to DNA-histone complexes. This correlation did not exist when complement-fixing activity was compared to the IgM nuclear patterns. Sera which contained only complement-fixing antibodies to denatured DNA and which did not react with native DNA or nucleoprotein did not produce the peripheral pattern of nuclear fluorescence. The data suggest that single strands of DNA were not the reactive groups in the nucleus responsible for the peripheral pattern. The results support the conclusion that DNA within a DNA-protein complex may be the nuclear antigen responsible for the peripheral pattern of nuclear fluorescence. Analysis of the clinical data revealed that a close correlation existed between the presence of IgG peripheral pattern, complement-fixing antibodies to DNA and histone-DNA complexes, and clinical manifestation of active disease.
Effect of Cat and Dog Ownership on Sensitization and Development of Asthma among Preteenage Children
Authors: Matthew S. Perzanowski, Eva Rönmark, Thomas A. E. Platts-Mills, Bo Lundbäck
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

An inverse relationship has been proposed between exposure to high quantities of cat allergen at home and both asthma and cat allergy. First- and second-grade children from Luleå, Kiruna, and Piteå, Sweden participated in an asthma questionnaire study (n = 3,431) and incidence was evaluated over the next 3 years. Skin testing was performed on the children in Luleå and Kiruna (n = 2,149). The strongest risk factor for incident cases of asthma was Type 1 allergy (relative risk [RR], 4.9 [2.9–8.4]), followed by a family history of asthma (RR, 2.83 [1.8–4.5]). Living with a cat was inversely related both to having a positive skin test to cat (RR, 0.62 [0.47–0.83]) and incidence of physician-diagnosed asthma (RR, 0.49 [0.28–0.83]). This effect on incident asthma was most pronounced among the children with a family history of asthma (RR, 0.25 [0.08–0.80]). The evidence also suggests that many of the children exposed to cats at home can develop an immune response that does not include immunoglobulin E. Weaker protective trends were seen with dog ownership. The traditional thinking that not owning cats can provide protection against developing allergy and asthma among those with a family history of allergy needs to be re-evaluated. In a community where cat sensitization was strongly associated with asthma, owning a cat was protective against both prevalent and incident asthma.
Do Available Questionnaires Measure the Communication Factors That Patients and Families Consider Important at End of Life?
Authors: Eva Grunfeld, Amy Folkes, Robin Urquhart
Journal: Journal of Clinical Oncology (2008)

Patients with advanced cancer report wanting better communication. Our previous research identified five specific communication domains important to end-of-life (EOL) cancer care: communicating information, interpersonal communication, communicating available supportive care services, communicating a transition in the objectives of care, and interprofessional communication. A literature review was conducted to identify patient-, family member-, or heath professional-reported questionnaires to measure these specific communication domains. On the basis of specific criteria, including validity and evidence base, 10 questionnaires were identified that have the potential to measure and monitor the quality of communication during EOL cancer care. No single questionnaire measured all five domains. There is a need to further develop questionnaires that have the capacity to specifically measure those communication domains that are important to patients with cancer and their families at EOL.
Help Seeking for Family Problems: A Survey of Utilization and Satisfaction
Authors: AARON ROSENBLATT, JOHN E. MAYER
Journal: American Journal of Psychiatry (1972)

Women of different races and educational backgrounds were compared to determine their utilization of mental health services and their satisfaction with them. As suspected, the distribution of services is uneven, with white women and women who were more educated seeking help from professionals more often than black women and women who were less educated. The least educated women, however, were the most satisfied with the help they received.
Survival (time to event) data: median survival times
Authors: P. Sedgwick, K. Joekes
Journal: BMJ (2011)

A meta-analysis investigated the effects of palliative chemotherapy in patients with locally advanced or metastatic colorectal cancer. Randomised controlled trials that compared palliative chemotherapy with supportive care were included. Seven trials with a common study period of 24 months were identified, providing individual data on a total of 866 patients. Outcome measures included the length of time until death after starting treatment. The Kaplan-Meier survival curves for the length of time until death for the treatments of palliative chemotherapy and supportive care were presented (figure⇓). The median survival time was estimated to be 8.0 months in the supportive care group and 11.7 months in the chemotherapy group.1



Kaplan­Meier survival curves of overall survival for the chemotherapy and supportive care treatment groups. The number of events (total deaths in each group) are indicated. The median survival time for each treatment group is the length of time corresponding to the probability of 0.51 …
Hematopoietic Responses to Radiation Injury
Authors: L O Jacobson
Journal: Annual Review of Medicine (1956)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More