tbuckley/cabot-search huggingface dataset:
Gordon Blair Drummond
Authors: G. Drummond
Journal: BMJ (2010)

Gordon Blair Drummond died on 19 December 2009 at the age of 102, after a stroke a few weeks before. He was a general practitioner in the Hessle Road area of Hull. He was born on 30 December 1906 in Leith, Scotland. He had a scholarship to Leith Academy, and in 1925 was apprenticed as a pharmacist, qualifying in 1929. Two years later he started medical studies, funded by having worked as a pharmacist. He qualified LRCP LRCS in Edinburgh in 1936 and after a short time as a GP assistant in Hull returned to Edinburgh to work as a surgical resident in Leith Hospital for six months.

He later claimed that no one would be able to survive longer: he lost about …
IMPACT OF MULTI-ELECTRODE RENAL SYMPATHETIC DENERVATION ON SHORT-TERM BLOOD PRESSURE VARIABILITY IN PATIENTS WITH DRUG-RESISTANT HYPERTENSION: INSIGHTS FROM THE ENLIGHTN I STUDY
Authors: Konstantinos P. Tsioufis, Vasilios Papademetriou, Dimitris Tsiachris, Alexandros Kasiakogias, Athanasios Kordalis, Konstantinos Thomopoulos, Kyriakos Dimitriadis, Dimitris Tousoulis, Christodoulos I Stefanadis, Gianfranco Parati, Stephen Worthley
Journal: Journal of the American College of Cardiology (2015)
Health secretary makes U turn over service closure at London hospital
Authors: Z. Kmietowicz
Journal: BMJ (2011)

Changes to services at Barnet and Chase Farm Hospitals in north London first proposed by the local NHS and backed by the Labour government in 2008 are to go ahead. The health secretary for England, Andrew Lansley, has accepted the findings of a review that found that reconfiguration is in the best interests of patients, despite promises by himself and the prime minister, David Cameron, before and after the election that the hospital would not be subjected to “top-down” changes.

Mr Lansley had asked the Independent Reconfiguration Panel, which is made up of doctors, managers, and lay people, to review the plans for the hospitals against four criteria, all of which must be passed: that the changes are backed by clinical evidence; that they have the support of GP commissioners; that they promote patients’ choice; and that they are agreed after engagement with the public, patients, …
Outbreak of West Nile virus infection among humans in Serbia, August to October 2012
Authors: N Popović, B Milošević, A Urošević, J Poluga, L Lavadinović, J Nedelijković, Dj Jevtović, O Dulović
Journal: Eurosurveillance (2013)

Binary file ES_Abstracts_Final_ECDC.txt matches
SP0169 JAK inhibition in patients with rheumatoid arthritis
Authors: J. Kremer
Journal: Annals of the Rheumatic Diseases (2013)

The Janus Kinase (JAK) group of tyrosine kinases are intracellular signaling molecules which become phosphorylated upon activation. There are 3 different JAK enzymes; JAK 1,2 and 3. Each of the JAK targets has somewhat different effects when inhibited. JAK activation is followed by phosphorylation of intracytoplasmic STAT tyrosine kinases which then lead to nuclear transcription of inflammatory mediators. Molecules in development for treatment of rheumatoid arthritis inhibit various JAK targets including CP-690,550 (JAK 1-3), INCB018424 and INCB028050 (JAK 1 and 2), VX-509 (JAK 3) and GLPG0634 (JAK1). JAK inhibition leads to down regulation of the interferon (IFN) related cytokines, the common γ chain cytokines (IL-2, IL-7, IL-9, IL-15, IL-21) as well as the gp130 family (including IL-6 and related proteins). Recently, CP-690,550 has also been shown to inhibit TNF-induced release of chemokines including IP-10, RANTES and MCP1. JAK inhibitors are small molecules with short half lives which can be administered orally in BID (CP-690,550; half life of 3 hrs) or QD dosing (INCBO28050; half life of 6 hrs). CP-690,550 has completed several phase III trials including use as: monotherapy; use with background DMARDs; and structure. INCBO18424, INCBO28050 and VX-509 are presently in Phase II. To date the JAK molecules appear to share certain side effects including transaminase and lipid increases (common) with occasional increases in serum Creatinine along with decreases in both hemoglobin, white blood cells and platelets which can occasionally become clinically significant. Their overall clinical efficacy profile is viewed as robust and generally viewed as being equivalent to approved biologic agents. Specifics of the clinical efficacy and toxicity profile of these agents will be reviewed along with a mechanistic overview. <h3>Disclosure of Interest</h3> None Declared
PTU-230 Outcomes of endoscopic human thrombin injection in the management of gastric varices
Authors: M Smith, R Tidswell, D Tripathi
Journal: Gut (2012)

<h3>Introduction</h3> The optimal therapy for gastric variceal bleeding remains unclear. Endoscopic Human Thrombin injection appears a technically simple and efficacious alternative to cyanoacrylate with fewer complications, but data remains limited. This study evaluated patient outcomes following thrombin injection for gastric varices. <h3>Methods</h3> Retrospective review of patients receiving endoscopic human thrombin injection for active bleeding or prevention of bleeding from gastric varices at a UK tertiary centre from December 2008 to November 2011. Thrombin injection (Tisseel 250 IU/ml, Baxter Int. Inc.) was repeated at intervals until varices eradicated. <h3>Results</h3> 23 patients (65% male, mean age 53.1 (SD 14.0)), received human thrombin injection for gastric varices. Mechanism of portal hypertension was cirrhosis 17 patients (74%), extra-hepatic 6 (26%). Cirrhosis was due to alcohol (10), viral (2), PBC (2), other (3); 4 had additional portal vein thrombosis. TIPSS was felt not feasible in 8 (35%). Mean MELD was 13 (SD 5). Childs grade A, B, C in 39%, 35% and 26% respectively. Varices were classified: IGV1 19 (83%), IGV2 3 (13%), GOV2 1 (4%). 14 patients (61%) were actively bleeding or had signs of recent bleeding; of these haemostasis was achieved in 12 (86%). Mean thrombin dose/injection was 1168 IU (range 400–2500); median number of sessions 2 (range 1–7) with no reported complications. Median follow-up was 476 days (IQR 193–931). No patient underwent liver transplantation. Rebleeding occurred in 9 (39%) patients, 5 (56%) within the first week (range 1–1008 days), 1 yr rebleeding rate 35%. Rebleeding was successfully managed in 78%, by salvage TIPSS (5 patients) and thrombin injection (2). Two patients died following rebleeding. Six deaths (26%) occurred in total all within 12 months; the remainder were due to uncontrolled bleeding (1), liver failure (1), MOF following OV bleed banded (1), and hepatocellular carcinoma (1). Cumulative survival at 1, 6, 12 months was 82%, 78%, and 74% respectively. Where TIPSS was precluded, 75% (6 of 8 patients) were managed successfully with thrombin. <h3>Conclusion</h3> Thrombin in our series appears to be a safe and effective endoscopic therapy for gastric varices, achieving good haemostasis with low medium to long term rebleeding rates. It may have particular utility in salvaging patients not suitable for TIPSS. <h3>Competing interests</h3> None declared.
Abstract 150: HPV and aberrant DNA methylation status in paired saliva and tumor samples in HNSCC
Authors: Shaleta Havard, Kang Mei Chen, Josena K. Stephen, Maria J. Worsham
Journal: Cancer Research (2010)

Abstract To examine the utility of non-invasive detection of high risk HPV and aberrant DNA methylation in matched saliva and tumor DNA in squamous head and neck cancer (HNSCC). In a cohort of 35 primary HNSCC with matched tumor (cases) and saliva specimens, HPV status was initially determined using the Linear Array HPV Genotyping kit and confirmed by PCR for HPV subtypes 16, 31, 33 and 45. Aberrant methylation of 24 tumor suppressor genes was interrogated using the methylation specific multiplex ligation probe amplification (MS-MLPA) assay. Of the 35 cases, 20 were negative for HPV in the saliva and tumor, 9 were positive for HPV in both and in 6 cases HPV was positive in the tumor specimen but not detected in the corresponding saliva. In the 9 cases that were positive for HPV in the tumor and matched saliva, 6 were HPV 16 positive and 1 case each was positive for HPV 31, 33 and 45. The sensitivity and specificity for HPV in this cohort were 100% and 60%, respectively. Promoter hypermethylation frequency in tumor samples was 60% (21/35) as compared to 14% (5/35) in saliva. The most frequently methylated genes in tumors included RARB-10/21, APC- 9/21, TIMP3 and CDKN2B- 7/21, CDKN2A and IGSF4- 5/21 tumor samples. The most frequently methylated genes in saliva samples included TIMP3, ESR1 and IGSF4 (3/5 saliva samples), followed by APC, CDKN2B and DAPK1 (2/3). Two of the 35 tumor and saliva pairs had commonly methylated genes, APC in one pair, and TIMP3, CDKN2B, ESR1 and IGSF4 in the other. There was no association between HPV and methylation. PCR analysis of HPV DNA in salivary rinses allows for detection of HPV and promoter methylation status in HNSCC and is a feasible noninvasive alternative to more invasive procedures. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 150.
Reply to Qin and Linghu
Authors: C. Schlag, A. Meining
Journal: Endoscopy (2013)

We thank Drs Qin and Linghu for their comments on our study, which applied a grasp-and-snare technique followed by over-the-scope clip (OTSC) closure for endoscopic resection of small gastric subepithelial tumors (SETs) [1].
Cooperative Group Evaluating Diagnostic Imaging Techniques
Authors: F. Antoine
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Cooperative Group Evaluating Diagnostic Imaging Techniques Get access Florence Antoine Florence Antoine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 18, 20 September 1989, Pages 1347–1349, https://doi.org/10.1093/jnci/81.18.1347 Published: 20 September 1989
PTU-042 DNA-PK or ATM inhibition inhibits non-homologous end joining and enhances chemo- and radio sensitivity in hepatocellular cancer cell lines
Authors: L Cornell, J Munck, N Curtin, H Reeves
Journal: Gut (2012)

<h3>Introduction</h3> Hepatocellular carcinoma (HCC) is chemotherapy resistance possibly due to dysregulation of DNA damage signalling and repair. DNA double-strand breaks (DSBs) are the most cytotoxic lesions induced by ionising radiation (IR) and anticancer drugs such as topoisomerase II poisons (eg, doxorubicin). DSBs are repaired by non-homologous end joining (NHEJ), initiated by DNA-dependent protein kinase (DNA-PK), and homologous recombination (HR), reportedly initiated by <i>Ataxia telangiectasia mutated</i> (ATM). DNA-PK is up-regulated in HCC (GEO profiles), possibly contributing to anticancer therapy resistance. To assess DNA-PK and ATM as therapeutic targets for chemo- and radio-sensitisation in HCC we determined the effect of their inhibition in HCC cell lines. <h3>Methods</h3> DNA-PK and ATM protein levels and activation by IR (Western blot), DSB levels (y-H2AX foci), HR (RAD51 foci), cell growth (DAPI fluorescence) and cytotoxicity (colony formation) following exposure to IR or doxorubicin was determined in a panel of 6 hepatoma cell lines (HepG2, Hep3B, Huh7, SNU-182, SNU475 and PLC/PRF/5). Studies were performed in the presence and absence of the DNA-PK inhibitor NU7441, and the ATM inhibitor KU55933. <h3>Results</h3> DNA-PK protein concentration and activity were high in all HCC cell lines. In contrast, ATM expression varied, and was lowest in Hep3B cells. Cell-specific sensitivities to IR and doxorubicin correlated with ATM expression (highest in HepG2 and lowest in Hep3B). NU7441 sensitised all cells to doxorubicin (average PF<sub>50</sub> 4.3±3.0) and IR (average PF<sub>50</sub> 3.9±1.1), significantly increasing growth inhibition and reducing survival (4.8 to 3.3-fold; colony forming assays). KU55933 significantly potentiated cytotoxicity in HepG2 cells (eightfold) but had little effect on cytotoxicity in Hep3B cells. Following exposure to IR, both NU7441 and KU55933 delayed DSB repair (∼50% clearance yH2AX foci at 4 h vs only 10%–15% in presence NU7441). NU7441 also enhanced HR (threefold increase in RAD51 foci), while KU55933 had little effect. <h3>Conclusion</h3> DNA-PK levels were high in all HCC cells and its inhibition with NU7441 was associated with significant chemo- and radio-sensitisation. Potentiation by ATM inhibition varied in the cell lines, reflecting the level of ATM expression. Both inhibitors substantially impaired the rapid phase of DNA repair commonly attributed to NHEJ. Notably, KU55933 had little effect on HR, suggesting that ATM is not central to this repair pathway. We propose that these inhibitors will increase the effectiveness of lower safer doses of cytotoxic therapies, amplifying tumour toxicity, and that DNA-PK and ATM levels in tumour and non-tumour liver will predict those patient likely to benefit. <h3>Competing interests</h3> None declared.
AB0226 Role of MRI in Diagnosing Patients of Early Arthritis with Suspicion of RA/Undifferentiated Arthritis Presenting Serologically and Clinically as Diagnostic Dilemma in Indian Population
Authors: B. Pandey
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> 47% of patients of RA have normal serology and no evidence of clinical synovitis posing a various diagnostic dilemma to the clinician. EULAR guides treat to target strategy in suspected patients of arthritis. Window of opportunity exists in initiation of early and aggressive treatment of arthritis to prevent further damage. <h3>Objectives</h3> 1.To be able to overcome the diagnostic dilemma of a disease affecting the joints being early arthritis in a set up of clinical and serological findings not being able to be helpful in making the diagnosis of ongoing inflammatory process. 2.The relationship of arthritic disease with carotid intimal thickness as a risk factor for cardiovascular disease in these patients. <h3>Methods</h3> A total of 33 patients 21 females and 12 males were studied. 25 patients were in age group of 45-78 years, 6 patients were in age group of 28-38 years and one patient of 15 years age, who were strongly suspected of early RA or undifferentiated arthritis were clinically and serologically worked up, when the diagnostic dilemma still persisted contrast enhanced MRI of the clinically more affected hand was done and scoring of synovitis, bone marrow edema, bone erosions were done according to RAMRIS. The finding of tenosynovitis, enthesitis, periostitis were also recorded. In such a equivocal scenario only 1 patient showed thrombocytosis,4 patients were RF positive, 4 patients were Anti CCP positive,18 patients showed raised ESR, 7 patients showed raised CRP, 7 patients showed raised ANA, 4 patients were hypothyroid and one patient had Anti Rho/La positive. Bilateral carotid intimal thickness were taken at a distance of approximately 2cm proximal to the carotid bulb. <h3>Results</h3> Out of the examined patients 28 showed synovitis, 7 showed bone marrow edema,12 patients showed erosions and 9 patients showed tenosynovitis, just 2 patients showed normal MRI findings.12 patients showed raised carotid intimal thickness. <h3>Conclusions</h3> MRI in the setting of serological and clinical limitation of diagnosing early or undifferentiated arthritis is of great help in establishing an undubious diagnosis of ongoing inflammatory changes in the synovium associated with or without erosions, bone marrow edema or just the presence of mere tenosynovitis and aided the clinician to stick to the goal of treat to target strategy.The study was helpful in guiding the clinician so as to start an aggressive or nonaggressive treatment. Carotid intimal thickness did not relate well as a risk of cardiovascular disease in such patients. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5078
Massive obscure-overt upper gastrointestinal bleeding secondary to hemobilia
Authors: P. Tan, E. Teo, K. Fock, T. Ang, J. Tan, A. Tan
Journal: Endoscopy (2009)

Hemobilia is an uncommon cause of upper gastrointestinal bleeding [1] [2]. Here we present two cases of obscure-overt upper gastrointestinal bleeding that were caused by hemobilia from a hepatic artery.
Diuretics and Renal Cell Cancer
Authors: J. K. MCLAUGHLIN, W. J. BLOT, J. F. FRAUMENI
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Diuretics and Renal Cell Cancer Get access JOSEPH K. MCLAUGHLIN, JOSEPH K. MCLAUGHLIN Epidemiology and Biostatistics Program Division of Cancer Etiology National Cancer InstituteBethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar WILLIAM J. BLOT, WILLIAM J. BLOT Epidemiology and Biostatistics Program Division of Cancer Etiology National Cancer InstituteBethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JOSEPH F. FRAUMENI, JR. JOSEPH F. FRAUMENI, JR. Epidemiology and Biostatistics Program Division of Cancer Etiology National Cancer InstituteBethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 5, 4 May 1988, Page 378, https://doi.org/10.1093/jnci/80.5.378 Published: 04 May 1988
Protection or Peril?
Authors: Arthur L. Kellermann, Donald T. Reay
Journal: New England Journal of Medicine (1986)

To study the epidemiology of deaths involving firearms kept in the home, we reviewed all the gunshot deaths that occurred in King County, Washington (population 1,270,000), from 1978 through 1983. The medical examiner's case files were supplemented by police records or interviews with investigating officers or both, to obtain specific information about the circumstances, the scene of the incident, the type of firearm involved, and the relationship of the suspect to the victim. A total of 743 firearm-related deaths occurred during this six-year period, 398 of which (54 percent) occurred in the residence where the firearm was kept. Only 2 of these 398 deaths (0.5 percent) involved an intruder shot during attempted entry. Seven persons (1.8 percent) were killed in self-defense. For every case of self-protection homicide involving a firearm kept in the home, there were 1.3 accidental deaths, 4.6 criminal homicides, and 37 suicides involving firearms. Hand-guns were used in 70.5 percent of these deaths. The advisability of keeping firearms in the home for protection must be questioned.
Abstract 4382: Genome-Wide Gene Expression analysis and molecular portraits regulated by NASEp, an inhibitor of CREB and CBP interaction, in non-small cell lung cancer.
Authors: Sin-Aye Park, James Platt, Hee Sun Park, Jong Woo Lee, David F. Stern, Roy S. Herbst, Jaseok Peter Koo
Journal: Cancer Research (2013)

Abstract Cyclic-AMP response element-binding protein (CREB)-cAMP response element (CRE) transcriptional pathway plays a critical role in the growth and survival of non-small cell lung cancer (NSCLC) cells. Recruitment of CREB binding protein (CBP) is essential for the transcriptional activity of CREB. However, there is no specific drug in use blocking CREB-CRE transcriptional pathway which may become a new therapeutic target in anti-cancer strategy. Naphthol AS-E phosphate (NASEp) was identified as an inhibitor of CREB transcriptional activity by binding to the KIX domain of CBP and blocking its access to the KID domain in CREB. Our objective was to identify which genes and molecular pathways could be affected by NASEp that may alter target molecules through the regulation of a subset of CRE-containing genes. The effects of the CREB inhibitor NASEp on A549 lung carcinoma cells were examined on an Affymetrix HuGene 1.0 expression microarray and a list of significantly differentially regulated genes was generated. Gene Set Enrichment Analysis (GSEA) shows down-regulation of multiple cancer-related pathways including proliferation, RAS signaling, drug resistance and metastasis. Most significantly, a strong negative correlation with Rosty Cervical Cancer Proliferation Cluster, shows that NASEp inhibits the same set of genes which are up regulated by the E6 and E7 viral oncogenes. These viral elements are known to interact with CBP, which is the direct target of NASEp. Since CBP is known to be a cofactor to multiple transcription factors, we performed an additional round of GSEA using the motif-based Transcription Factor Targets gene set collection and represented the results using a Cytoscape network diagram to illustrate the multifactorial effects of NASEp. Particularly, we focused that several transcription factors regulating cell cycle-related genes. This study implicates potential combinational blockage of CREB and cell cycle-regulated proteins as a cancer therapy. Citation Format: Sin-Aye Park, James Platt, Hee Sun Park, Jong Woo Lee, David F. Stern, Roy S. Herbst, Jaseok Peter Koo. Genome-Wide Gene Expression analysis and molecular portraits regulated by NASEp, an inhibitor of CREB and CBP interaction, in non-small cell lung cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4382. doi:10.1158/1538-7445.AM2013-4382
Medicine and the Ministry: A Medical Basis for Pastoral Care
Authors: D. P. McWhirter
Journal: JAMA (1967)

Despite the fact that in recent years a number of books dealing with the subject of pastoral counseling have been published, there has not been an adequate publication dealing with the general problems of medicine and the ministry written especially for clergymen. Dr. Sharpe has made an attempt to fill this void with his book,<i>Medicine and the Ministry</i>. Unfortunately, the book has many shortcomings, lacking any type of freshness or enthusiasm in exploring a relationship between the ministry and medicine which has persisted from the beginnings of both. The table of contents offers a wide variety of interesting material, but the text has a tendency to read like an etiquette manual for clerical behavior in medical situations. The major portion of the book deals with psychiatric problems, shallowly covering old diagnostic categories without offering the new insights of modern psychiatric practice or understanding. No attempt is made to demonstrate