Resin Hemoperfusion for Treatment of a Massive Meprobamate Overdose
Authors: WENDY E. HOY
Journal: Annals of Internal Medicine (1980)

Brief Reports1 September 1980Resin Hemoperfusion for Treatment of a Massive Meprobamate OverdoseWENDY E. HOY, M.B., B.S., ALEJANDRO RIVERO, M.D., MATTHEW G. MARIN, M.D., FREDRIC RIEDERS, Ph. D.WENDY E. HOY, M.B., B.S.Search for more papers by this author, ALEJANDRO RIVERO, M.D.Search for more papers by this author, MATTHEW G. MARIN, M.D.Search for more papers by this author, FREDRIC RIEDERS, Ph. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-3-455 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemoperfusion with Amberlite XAD-4 resin (X-R004 cartridge; Extracorporeal Medical Specialties, Inc., King of Prussia, Pennsylvania) (1) removes meprobamate from plasma and produces better drug clearance than does charcoal hemoperfusion (2). We report here two life-saving XAD-4 hemoperfusions in a patient with a massive meprobamate overdose in which the efficient calculated extraction of drug was confirmed by subsequent recovery of a large quantity of meprobamate from the used cartidges.A 39-year-old man ingested 200 g of meprobamate and a quantity of other drugs. His stomach contained many pill fragments, and charcoal slurry and magnesium citrate were instilled. He became comatose and...References1. ROSENBAUM J, KRAMER M, and RAJA R. Resin hemoperfusion for acute drug intoxication. Arch Intern Med. 1976;136:263-6. CrossrefMedlineGoogle Scholar2. HOY W, SCHWAB G, and FREEMAN R. Clearance of meprobamate by hemoperfusion over columns of charcoal and amberlite resin: studies in a patient. Artif Organs. 1978;2:395-7. CrossrefMedlineGoogle Scholar3. MAES R, HODNETT N, LANDESMAN H, KANANEN G, FINKLE B, and SUNSHINE I. The gas chromatographic determination of selected sedatives (ethchlorvynol, paraldehyde, meprobamate and caprisoprodol) in biological material. J Forensic Sci. 1969;14:235-54. MedlineGoogle Scholar4. SCHWARTZ H. Acute meprobamate poisoning with gastrotomy and removal of a drug-containing mass. N Engl J Med. 1976;295:1177-8. CrossrefMedlineGoogle Scholar5. MADDOCK R and BLOOMER H. Meprobamate overdosage, evaluation of its severity and methods of treatment. JAMA. 1967;201:999-1003. CrossrefMedlineGoogle Scholar6. JENIS E, PAYNE R, and GOLDBAUM L. Acute meprobamate poisoning: a fatal case following a lucid interval. JAMA. 1969;207:361-2. CrossrefMedlineGoogle Scholar7. POWELL L, MANN G, and KAYE S. Acute meprobamate poisoning. N Engl J Med. 1958;259:716-8. CrossrefMedlineGoogle Scholar8. WALKENSTEIN S, KNEBEL C, MACMULLEN J, and SEIFTER J. The excretion and distribution of meprobamate and its metabolites. J Pharmacol Exp Ther. 1958;123:254-8. MedlineGoogle Scholar9. AGRANOFF B, BRADLEY R, and AXELROD J. Determination and physiologic disposition of meprobamate. Proc Soc Exp Biol Med. 1957;96:261-4. CrossrefMedlineGoogle Scholar10. LORCH J and GARELLA S. Hemoperfusion to treat intoxications. Ann Intern Med. 1979;91:301-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WENDY E. HOY, M.B., B.S.; ALEJANDRO RIVERO, M.D.; MATTHEW G. MARIN, M.D.; FREDRIC RIEDERS, Ph. D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacokinetics of meprobamate in overdose treated with continuous venovenous hemodiafiltration (CVVHDF)MeprobamateBarbituriques et autres hypnotiques et sédatifsBarbiturates and Other Hypnotics and SedativesHypnotics, sedatives and antipsychoticsMeprobamate Kinetics During and After Terminated Hemoperfusion in acute IntoxicationsArterial-Venous Plasma Concentration Differences of Meprobamate in Acute Human PoisoningsDiagnosis and Treatment of Drug OverdoseTreatment of meprobamate overdose with repeated oral doses of activated charcoalExtracorporeal Therapy in the Treatment of IntoxicationDrugs and the KidneyAmikacin Is Not Removed By XAD-4 Hemoperfusion 1 September 1980Volume 93, Issue 3Page: 455-456KeywordsAddictionBlood plasmaComaDrugsHemoperfusionMagnesiumStomach ePublished: 1 December 2008 Issue Published: 1 September 1980 PDF downloadLoading ...