SUGAR ALCOHOLS XXIV. THE METABOLISM OF SORBITOL IN DIABETES
Authors: FRED W.  ELLIS, JOHN C.  KRANTZ JR.
Journal: Annals of Internal Medicine (1943)

Article1 May 1943SUGAR ALCOHOLS XXIV. THE METABOLISM OF SORBITOL IN DIABETESFRED W. ELLIS, PH.D., JOHN C. KRANTZ JR., PH.D.FRED W. ELLIS, PH.D.Search for more papers by this author, JOHN C. KRANTZ JR., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-5-792 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSorbitol was introduced into therapeutics in Europe under the name of "Sionin" by Thannhauser and Meyer1 in 1929. Since that time various workers have investigated its value as a substitute for carbohydrate in the diabetic diet with no consistent findings. Reinwein2 administered sorbitol to diabetics and observed an increase in the respiratory quotient but no rise in blood sugar. On the other hand, Roche and Raybaud3 observed no increase in the respiratory quotient, and Donhoffer and Donhoffer4 reported a rise in blood sugar after giving sorbitol to diabetic patients.Kaufmann5reported that sorbitol exhibited a protein-sparing action and was useful...Bibliography1. THANNHAUSERMEYER SJKH: Sorbit (Sionin) als Kohlehydratersatz für den Diabeteskranken, München. med. Wchnschr., 1929, lxxvi, 356. Google Scholar2. REINWEIN H: Über die Verwertbarkeit des d-Sorbit in der Behandlung des Diabetes mellitus, Deutsch. Arch. f. klin. Med., 1929, clxiv, 61. Google Scholar3. ROCHERAYBAUD AA: Sur l'utilization de la sorbite par l'organisme, Compt.-rend. Soc. de biol., 1933, cxiii, 320. Google Scholar4. DONHOFFERDONHOFFER SM: Über die klinische Untersuchung des Kohlenhydratstoffwechsels mittels d-Sorbit, Deutsch. Arch. f. klin. Med., 1930, clxvii, 257. Google Scholar5. KAUFMANN E: Ein neuer Kohlenhydratersatz zur Diabetesbehandlung, Klin. Wchnschr., 1929, viii, 66. CrossrefGoogle Scholar6. GOTTSCHALK A: Die Bedeutung der Ersatzkohlenhydrate für die Praxis und Theorie der Zuckerkrankheit, Ergebn. d. inn. Med. u. Kinderh., 1929, xxxvi, 56. Google Scholar7. VON NOORDEN KH: Sionin in der Diabetesbehandlung, Deutsch. med. Wchnschr., 1929, lv, 483. Google Scholar8. BERTRANDRADAISLABBÉ GM: Sur l'emploi de la sorbite dans l'alimentation des diabetiques, Bull. Acad. de méd., 1934, cxii, 8. Google Scholar9. PAYNELAWRENCEMCCANCE WWRDRA: Sorbitol (Sionin) for diabetics, Lancet, 1933, ccxxv, 1257. CrossrefGoogle Scholar10. RAYBAUDROCHE AA: Valeur dietetique de la sorbite dans la cure diabete sucre, Presse méd., 1934, xlii, 172. Google Scholar11. SILVERREINER SM: Essential fructosuria, Arch. Int. Med., 1934, liv, 412. CrossrefGoogle Scholar12. ELLISKRANTZ FWJC: Metabolism and toxicity studies with mannitol and sorbitol in man and animals, Jr. Biol. Chem., 1941, cxli, 147. CrossrefGoogle Scholar13. EMBDENGRIESBACH GW: Über das Schicksal des d-Sorbits und einiger anderer Hexite, Ztschr. f. physiol. Chem., 1914, xci, 251. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication June 10, 1942.From the Department of Pharmacology, School of Medicine, University of Maryland.The expense of this work was defrayed in part by a grant from the Atlas Powder Company of Wilmington, Delaware. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuality of ‘Royal Gala’ cut apple during osmotic dehydrationThe utilization and metabolism of intravenous sorbitolDaily intake assessment of saccharin, stevioside, D-sorbitol and aspartame from various processed foods in KoreaHealth potential of polyols as sugar replacers, with emphasis on low glycaemic propertiesSComparison of glucose, fructose, sorbitol, and xylitol utilization in humans during insulin suppressionPhysiologische Chemie der Lebensvorgänge und Organe�ber den intermedi�ren Stoffwechsel des Sorbits im KindesalterZur Resorption von Sorbit und MannitClinical Use of Sorbitol as a Sweetening Agent in Diabetes MellitusSORBITOL METABOLISM IN ALLOXAN-DIABETIC ANIMALS AS COMPARED WITH FRUCTOSE AND GLUCOSE bMetabolism of the Sugar Alcohols and Their Derivatives 1 May 1943Volume 18, Issue 5Page: 792-796KeywordsAlcoholsBlood sugarCarbohydratesDietPharmacologyProteins ePublished: 1 December 2008 Issue Published: 1 May 1943 PDF downloadLoading ...