Review: Calcium supplementation and risk for fracture in persons > 50 years of age
Authors: Calvin Hirsch
Journal: Annals of Internal Medicine (2016)

ACP Journal Club19 January 2016Review: Calcium supplementation and risk for fracture in persons > 50 years of ageCalvin Hirsch, MDCalvin Hirsch, MDUniversity of California, Davis, Sacramento, USA (C.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2016-164-2-004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationBolland MJ, Leung W, Tai V, et al. Calcium intake and risk of fracture: systematic review. BMJ. 2015;351:h4580. https://pubmed.ncbi.nlm.nih.gov/26420387Clinical Impact RatingsGIM/FP/GP: Geriatrics: References1 Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. 2011;342:d2040. [PMID: 21505219] Google Scholar2 Xiao Q, Murphy RA, Houston DK, et al. Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health–AARP diet and health study. JAMA Intern Med. 2013;173:639-46. [PMID: 23381719] Google Scholar3 Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. National Academy of Sciences, Washington, D.C.; 2010. iom.nationalacademies.org/reports/2010/dietary-reference-intakes-for-calcium-and-vitamin-d.aspx. Accessed 16 Nov 2015. Google Scholar4 U.S. Preventive Services Task Force. Final Recommendation Statement. Vitamin D and Calcium to Prevent Fractures: Preventive Medication 2013; www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/vitamin-d-and-calcium-to-prevent-fractures-preventive-medication. Accessed 16 Nov 2015. Google Scholar5 Volkert D, Kreuel K, Heseker H, Stehle P. Energy and nutrient intake of young-old, old-old and very-old elderly in Germany. Eur J Clin Nutr. 2004;58:1190-200. [PMID: 15054435] Google Scholar6 Nordin BE, Need AG, Morris HA, O’Loughlin PD, Horowitz M. Effect of age on calcium absorption in postmenopausal women. Am J Clin Nutr. 2004;80:998-1002. [PMID: 15447911] Google Scholar7 Valcour A, Blocki F, Hawkins DM, Rao SD. Effects of age and serum 25-OH-vitamin D on serum parathyroid hormone levels. J Clin Endocrinol Metab. 2012;97:3989-95. [PMID: 22933544] Google Scholar8 Adami S, Viapiana O, Gatti D, Idolazzi L, Rossini M. Relationship between serum parathyroid hormone, vitamin D sufficiency, age, and calcium intake. Bone. 2008;42:267-70. [PMID: 18024243] Google Scholar9 Lips P, Gielen E, van Schoor NM. Vitamin D supplements with or without calcium to prevent fractures. Bonekey Rep. 2014;3:512. [PMID: 24818004] Google Scholar10 van der Velde RY, Brouwers JR, Geusens PP, Lems WF, van den Bergh JP. Calcium and vitamin D supplementation: state of the art for daily practice. Food Nutr Res. 2014;58. [PMID: 25147494] Google Scholar11 Jackson RD, LaCroix AZ, Gass M, et al; Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006;354:669-83. [PMID: 16481635] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, Davis, Sacramento, USA (C.H.)This article was published at Annals.org on 5 January 2016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReview: Dietary or supplemental calcium increase BMD by ≤ 1.8% in persons > 50 years of age Calvin Hirsch Review: Dietary or supplemental calcium increase BMD by ≤ 1.8% in persons > 50 years of age Calvin Hirsch Metrics Cited byBone Biology and Effects of Pharmaceutical Intervention on Bone Quality 19 January 2016Volume 164, Issue 2Page: JC4KeywordsBone mineral densityCalciumFallsMortalityMyocardial infarctionRelative riskRenal failureResearch fundingSystematic reviewsVitamin D ePublished: 19 January 2016 Issue Published: 19 January 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...