tbuckley/cabot-search huggingface dataset:
Kidney Organoids Grown From Stem Cells
Authors: Tracy Hampton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011
Authors: P Gaibani, S Ambretti, A Berlingeri, M Cordovana, P Farruggia, M Panico, M P Landini, V Sambri
Journal: Eurosurveillance (2011)

Between July 2011 and August 2011, the New Delhi metallo-beta-lactamase 1 (NDM-1) gene was detected in Klebsiella pneumoniae and Escherichia coli isolates obtained from six patients hospitalised in four healthcare facilities in northern Italy. The patient who had been hospitalised in New Delhi, India, from February to May 2011 and subsequently in the Bologna area, Italy, from May to July 2011, may have been the source of the outbreak. Our findings suggest ongoing spread of this carbapenem-resistance gene in Italy and highlight the need for intensive surveillance.
E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis
Authors: Pierre-Damien Denechaud, Isabel C. Lopez-Mejia, Albert Giralt, Qiuwen Lai, Emilie Blanchet, Brigitte Delacuisine, Brandon N. Nicolay, Nicholas J. Dyson, Caroline Bonner, François Pattou, Jean-Sébastien Annicotte, Lluis Fajas
Journal: Journal of Clinical Investigation (2015)

E2F transcription factors are known regulators of the cell cycle, proliferation, apoptosis, and differentiation. Here, we reveal that E2F1 plays an essential role in liver physiopathology through the regulation of glycolysis and lipogenesis. We demonstrate that E2F1 deficiency leads to a decrease in glycolysis and de novo synthesis of fatty acids in hepatocytes. We further demonstrate that E2F1 directly binds to the promoters of key lipogenic genes, including Fasn, but does not bind directly to genes encoding glycolysis pathway components, suggesting an indirect effect. In murine models, E2F1 expression and activity increased in response to feeding and upon insulin stimulation through canonical activation of the CDK4/pRB pathway. Moreover, E2F1 expression was increased in liver biopsies from obese, glucose-intolerant humans compared with biopsies from lean subjects. Finally, E2f1 deletion completely abrogated hepatic steatosis in different murine models of nonalcoholic fatty liver disease (NAFLD). In conclusion, our data demonstrate that E2F1 regulates lipid synthesis and glycolysis and thus contributes to the development of liver pathology.
IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer
Authors: Vasiliki Koliaraki, Manolis Pasparakis, George Kollias
Journal: The Journal of Experimental Medicine (2015)

The importance of mesenchymal cells in inflammation and/or neoplastic transformation is well recognized, but their role in the initiation of these processes, particularly in the intestine, remains elusive. Using mouse models of colorectal cancer, we show that IKKβ in intestinal mesenchymal cells (IMCs) is critically involved in colitis-associated, but not spontaneous tumorigenesis. We further demonstrate that IMC-specific IKKβ is involved in the initiation of colitis-associated cancer (CAC), as in its absence mice develop reduced immune cell infiltration, epithelial cell proliferation, and dysplasia at the early stages of the disease. At the molecular level, these effects are associated with decreased early production of proinflammatory and protumorigenic mediators, including IL-6, and reduced STAT3 activation. Ex vivo IKKβ-deficient IMCs show defective responses to innate immune stimuli such as LPS, as shown by decreased NF-κB signaling and reduced expression of important NF-κB target genes. Collectively, our results reveal a hitherto unknown role of mesenchymal IKKβ in driving inflammation and enabling carcinogenesis in the intestine.
Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men Regulation by estrogen
Authors: L Molero
Journal: Cardiovascular Research (2002)

Objectives: (a) To identify the subtype of estrogen receptor (ER) expressed in neutrophils from premenopausal women and in neutrophils from men under different estrogen conditions and (b) to analyze the association between the modifications in the expression of ER subtypes and neuronal nitric oxide synthase (nNOS) expression induced by estrogen. Methods: Neutrophils were isolated from pre-menopausal women during different stages of the menstrual cycle and from ten men for in vitro estrogen incubations. Results: Neutrophils from premenopausal women expressed both ERα and ERβ subtypes which were increased in the ovulatory phase of the menstrual cycle. Neutrophils derived from men also expressed ERα and ERβ but only ERα expression was enhanced by in vitro incubation with 17β-estradiol (10−8 mol/l). In vitro incubation of neutrophils from women with 17β-estradiol enhanced expression of both ER-α and ER-β subtypes. nNOS protein was overexpressed in neutrophils from premenopausal women during the ovulatory phase. 17β-Estradiol (10−8 mol/l) also increased nNOS protein expression in neutrophils derived from men. Mithramycin A (10−6 mol/l) and curcumin (10−6 mol/l), prevented the upregulation of nNOS and ERα in neutrophils derived from men, suggesting the involvement of AP-1 and Sp-1 transcription factors. Conclusions: Although the in vivo levels of circulating estrogen concentrations seem to be associated with overexpression of both ERα and ERβ in neutrophils from premenopausal women, which was further confirmed by the in vitro experiments with neutrophils from women, in vitro incubation of neutrophils from men with 17β-estradiol only increased ERα protein expression which was associated with enhanced expression of nNOS protein.
Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein.
Authors: M McGrogan, C Simonsen, R Scott, J Griffith, N Ellis, J Kennedy, D Campanelli, C Nathan, J Gabay
Journal: The Journal of Experimental Medicine (1988)

A 14-kD protein was purified from human PMNs and its NH2-terminal sequence was determined. Comparison of a portion of the NH2-terminal sequence of this protein to the recently reported NH2-terminal sequence of eosinophil major basic protein (MBP) showed them to be identical. To aid further characterization of the structural and functional properties of this molecule, we isolated from an HL-60 cDNA library a single class of cDNA clones whose sequence matched exactly the NH2-terminal amino acid sequence of the 14-kD polypeptide. Northern analysis of HL-60 cells suggests that MBP is constitutively expressed in HL-60 cells and is highly transcribed from a single copy gene. The sequence of the full-length cDNA clones predicts that MBP is synthesized as a 23-kD precursor form (pro-MBP) which is subsequently cleaved to release the mature 14-kD MBP. The putative pro-MBP has a predicted pI of 6.0, but both the charged and the hydrophobic residues are asymmetrically distributed, creating a bipolar molecule. The NH2-terminal half has a predicted pI of 3.7 and is hydrophilic, while the COOH-terminal half (corresponding to mature MBP) has a predicted pI of 11.1 and is hydrophobic.
Impact of EGFR Inhibitor in Non–Small Cell Lung Cancer on Progression-Free and Overall Survival: A Meta-Analysis
Authors: Chee Khoon Lee, Chris Brown, Richard J. Gralla, Vera Hirsh, Sumitra Thongprasert, Chun-Ming Tsai, Eng Huat Tan, James Chung-Man Ho, Da Tong Chu, Adel Zaatar, Jemela Anne Osorio Sanchez, Vu Van Vu, Joseph Siu Kie Au, Akira Inoue, Siow Ming Lee, Val Gebski, James Chih-Hsin Yang
Journal: JNCI Journal of the National Cancer Institute (2013)

BackgroundThe epidermal growth factor receptor (EGFR) signaling pathway is crucial for regulating tumorigenesis and cell survival and may be important in the development and progression of non–small cell lung cancer (NSCLC). We examined the impact of EGFR–tyrosine kinase inhibitors (TKIs) on progression-free survival (PFS) and overall survival (OS) in advanced NSCLC patients with and without EGFR mutations.
P-269 Phase II trial of Irinotecan/S-1 (IRIS) with Cetuximab (IRIS/Cet) as second line treatment in patients with KRAS WT metastatic colorectal cancer: HGCSG0902. -Comparison of administration interval in Cetuximab treatment
Authors: K. Hatanaka, S. Yuki, H. Nakatsumi, A. Hosokawa, M. Nakamura, O. Muto, T. Meguro, I. Iwanaga, Y. Tsuji, A. Sato, K. Eto, K. Furukawa, M. Onodera, M. Tateyama, Y. Takahashi, M. Dazai, S. Yokoyama, T. Honda, H. Okuda, M. Kudo, Y. Sakata, Y. Komatsu
Journal: Annals of Oncology (2015)
Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience
Authors: Georgeanna J. Klingensmith, Laura Pyle, Kristen J. Nadeau, Linda A. Barbour, Robin S. Goland, Steven M. Willi, Barbara Linder, Neil H. White
Journal: Diabetes Care (2015)

OBJECTIVE We evaluated pregnancy outcomes, maternal and fetal/neonatal, during the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study. RESEARCH DESIGN AND METHODS The TODAY study was a randomized controlled trial comparing three treatment options for youth with type 2 diabetes. Informed consent included the requirement for contraception, including abstinence; this was reinforced at each visit. Following informed consent, self-reported data related to the mother’s prenatal care and delivery and the infant’s health were retrospectively collected. When permitted, maternal medical records and infant birth records were reviewed. RESULTS Of the 452 enrolled female participants, 46 (10.2%) had 63 pregnancies. Despite continued emphasis on adequate contraception, only 4.8% of the pregnant participants reported using contraception prior to pregnancy. The mean age at first pregnancy was 18.4 years; the mean diabetes duration was 3.17 years. Seven pregnancies were electively terminated; three pregnancies had no data reported. Of the remaining 53 pregnancies, 5 (9.4%) resulted in early pregnancy loss, and 7 (13%) resulted in loss with inadequate pregnancy duration data. Two pregnancies ended in stillbirth, at 27 and 37 weeks, and 39 ended with a live-born infant. Of the live-born infants, six (15.4%) were preterm and eight (20.5%) had a major congenital anomaly. CONCLUSIONS Despite diabetes-specific information recommending birth control and the avoidance of pregnancy, 10% of the study participants became pregnant. Pregnancies in youth with type 2 diabetes may be especially prone to result in congenital anomalies. Reasons for the high rate of congenital anomalies are uncertain, but may include poor metabolic control and extreme obesity.
Storage Duration and Other Measures of Quality of Red Blood Cells for Transfusion
Authors: Philip C. Spinella, Jason Acker
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>CCR</i> 20th Anniversary Commentary: Molecular Pathology of <i>ALK</i>-Rearranged Lung Tumors
Authors: A. John Iafrate
Journal: Clinical Cancer Research (2015)

Abstract The article by Rodig and colleagues, which was published in the August 15, 2009, issue of Clinical Cancer Research, helped detail the clinicopathologic profile of ALK-positive tumors and initiated the development of ALK diagnostics. Subsequent clinical trials utilized these findings, resulting in the approval of effective targeted therapies. The ALK story is a model for the development of therapies in the genomic era. Clin Cancer Res; 21(23); 5185–7. ©2015 AACR. See related article by Rodig et al., Clin Cancer Res 2009;15(16) August 15, 2009;5216–23
Synthetic and Fermentation-Derived Angiotensin-Converting Enzyme Inhibitors
Authors: M. Cohen
Journal: The Annual Review of Pharmacology and Toxicology (1985)

Over the past two decades, deadly coronaviruses, with the most recent being the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019 pandemic, have majorly challenged public health. The path for virus invasion into humans and other ...Read More
Systemic immunotherapy of superficial mouse bladder cancer with Avelumab (MSB0010718C), an anti-PD-L1 immune checkpoint inhibitor
Authors: Amanda Vandeveer, Jonathan Fallon, Robert Tighe, Helen Sabzevari, Jeffrey Schlom, John Greiner
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Bladder cancer is considered a malignancy that is responsive to immunotherapy because of the presence of a (a) high number of somatic mutations, (b) large number of tumor-infiltrating lymphocytes and (c) clinical response to the immune stimulant, Bacillus Calmette-Guerin (BCG).
Germline Manipulation and Our Future Worlds
Authors: John Harris
Journal: The American Journal of Bioethics (2015)

Two genetic technologies capable of making heritable changes to the human genome have revived interest in, and in some quarters a very familiar panic concerning, so-called germline interventions. These technologies are: most recently the use of CRISPR/Cas9 to edit genes in non-viable IVF zygotes and Mitochondrial Replacement Therapy (MRT) the use of which was approved in principle in a landmark vote earlier this year by the United Kingdom Parliament. The possibility of using either of these techniques in humans has encountered the most violent hostility and suspicion. However it is important to be aware that much of this hostility dates back to the fears associated with In Vitro Fertilization (IVF) and other reproductive technologies and by cloning; fears which were baseless at the time concerning both IVF and cloning the use of both of which have proved to be highly beneficial to humanity and which have been effectively regulated and controlled. This paper argues that CRISPR should by pursued through researh until it is safe enough for use in humans but there is no reason to suppose at this stage that such use will be unsafe or unethical (Collins 2015).
Statistical method for estimating the standard errors of branch lengths in a phylogenetic tree reconstructed without assuming equal rates of nucleotide substitution among different lineages.
Authors: F Tajima
Journal: Molecular Biology and Evolution (1992)

A statistical method is developed for estimating the standard errors of branch lengths in a phylogenetic tree reconstructed without assuming equal rates of nucleotide substitution among different lineages. This method can be easily used for testing whether the length of an interior branch in a reconstructed tree is positive, i.e., whether the topology of the tree is correct. Computer simulations indicate that this method is appropriate for a statistical test. As an example, this method is applied to phylogenetic trees reconstructed for the four hominoid species: human, chimpanzee, gorilla, and orangutan. The results obtained show that the present method provides a powerful statistical test.
Antiphospholipid Anti-bodies: Autoantibodies With A Difference
Authors: E. Harris
Journal: Annual Review of Medicine (1988)

Antiphospholipid antibodies may be detected by solid phase anti­ cardiolipin antibody tests, the lupus anticoagulant test, or standard tests for syphilis (STS). The occurrence of these antibodies has been associated with venous or arterial thrombosis, fetal loss, and possibly thrombo­ cytopenia. Other suggested features that may be associated with these antibodies include livedo reticularis, migraine, chorea, and heart valve lesions. Uncontrolled studies of small numbers of affected women with recurrent fetal loss suggest that prednisone and aspirin therapy during pregnancy may improve pregnancy outcome. Anticoagulant therapy is recommended for patients with thrombosis for as long as antiphospho­ lipid antibodies persist.
Paclitaxel and carboplatin in combination with gemcitabine: A phase I-II trial in patients with advanced non-small-cell lung cancer
Authors: A Favaretto, G L Ceresoli, A Paccagnella, F Barbieri, A Bearz, C Ghiotto, F Oniga, S Schiavon, S Frustaci, E Villa
Journal: Annals of Oncology (2000)
Previously defined 53 immune gene panel predicts melanoma survival using The Cancer Genome Atlas (TCGA)
Authors: Robyn Gartrell, Qian Yingzhi, Lopez Gonzalo, Fu Yichun, White-Stern Ashley, Bansal Mukesh, Sivendran Shanthi, Califano Andrea, Chang Rui, Saenger Yvonne
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Our laboratory has discovered a 53-immune gene panel predictive of survival in patients with stage II-III melanoma[[1][1]]. Validation is planned using tissues from a multi-institutional cooperative group study. We tested the 53-immune gene panel using publicly available data for
The impact of T cell percentage at CTL019 T cell expansion process initiation on post-harvest T cell composition.
Authors: Tatiana Golovina, Eric Drew, Joseph Sieling, Brian Gismonde, Marty Giedlin
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Assess the range of starting T cell percentage in the CTL019 expansion process. The current CTL019 process targets 450e9 total nucleated cells (TNC) at seeding of the static culture bags prior to activation and transduction (Kalos M et al. 2011; Maude et al. 2014). However, less
On Real-Time Estimates of Blood Sugar Levels
Authors: Jan Bolinder, Dorothee Deiss, Moshe Phillip
Journal: Diabetes Care (2007)

The GuardControl Study (1) demonstrated the impact of real-time continuous glucose monitoring relative to standard care (self-monitored blood glucose) on glycemic control. Glycemic control was measured by A1C at months 0 (baseline), 1, and 3. Repeated-measures ANOVA, in which the dependence among repeated A1C measures …
Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group
Authors: Isabelle Thibault, Eric L Chang, Jason Sheehan, Manmeet S Ahluwalia, Matthias Guckenberger, Moon-Jun Sohn, Samuel Ryu, Matthew Foote, Simon S Lo, Alexander Muacevic, Scott G Soltys, Samuel Chao, Peter Gerszten, Eric Lis, Eugene Yu, Mark Bilsky, Charles Fisher, David Schiff, Michael G Fehlings, Lijun Ma, Susan Chang, Edward Chow, Wendy R Parelukar, Michael A Vogelbaum, Arjun Sahgal
Journal: The Lancet Oncology (2015)
Response to Letter Regarding Article, “Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management”
Authors: Kei Hayashida, Motoaki Sano, Naomi Kamimura, Takashi Yokota, Masaru Suzuki, Shigeo Ohta, Keiichi Fukuda, Shingo Hori
Journal: Circulation (2015)
Tumor necrosis factor alpha is a potent synergistic factor for the proliferation of primitive human hematopoietic progenitor cells and induces resistance to transforming growth factor beta but not to interferon gamma.
Authors: H W Snoeck, S Weekx, A Moulijn, F Lardon, M Lenjou, G Nys, P C Van Ranst, D R Van Bockstaele, Z N Berneman
Journal: The Journal of Experimental Medicine (1996)

Since tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and transforming growth factor (TGF)-beta have all been shown to be specific inhibitors of early human hematopoiesis, we wanted to investigate the interactions of these three cytokines on very primitive human adult bone marrow CD34++CD38- hematopoietic progenitor cells, using a pre-colony-forming cell (pre-CFC) assay, which detects the effects of these cytokines on the initial phases of the differentiation of these primitive progenitors, which are unresponsive to interleukin (IL) 3 alone. Surprisingly, TNF-alpha was a very potent stimulator of the proliferation of CD34++CD38- cells and was the most potent synergistic factor for the IL-3-induced proliferation of these cells of all cytokines tested (IL-1, IL-6, granulocyte colony-stimulating factor, kit ligand). TNF-alpha was the only cytokine that, as a single added factor, induced substantial proliferation in CD34++CD38- cells in the presence of IL-3, except for kit ligand, which induced very limited proliferation. TNF-alpha, moreover, induced a high degree of resistance to the inhibitory effects of TGF-beta in a dose-dependent way. The inhibitory effects of IFN-gamma, however, were not affected by the presence of TNF-alpha. We hypothesize that in situations of the hematopoietic stress, TNF-alpha may abrogate the inhibitory effect of ambient TGF-beta in the bone marrow microenvironment to allow primitive stem cells to proliferate and differentiate in response to an increased demand for mature blood cells.
BEACOPP: An intensified chemotherapy regimen in advanced Hodgkin's disease
Authors: V. Diehl, M. Sieber, U. Rüffer, B. Lathan, D. Hasenclever, M. Pfreundschuh, M. Loeffler, D. Lieberz, P. Koch, M. Adler, H. Tesch
Journal: Annals of Oncology (1997)
Arterial remodeling patterns before intervention predict diffuse in-stent restenosis
Authors: Makoto Sahara, Hajime Kirigaya, Yuji Oikawa, Junji Yajima, Ken Ogasawara, Hiroshi Satoh, Kazuyuki Nagashima, Hitoshi Hara, Yusuke Nakatsu, Tadanori Aizawa
Journal: Journal of the American College of Cardiology (2003)