tbuckley/cabot-search huggingface dataset:
Physical and Psychological Morbidity After Axillary Lymph Node Dissection for Breast Cancer
Authors: Thomas F. Hack, Lorenzo Cohen, Joel Katz, Lynda S. Robson, Paul Goss
Journal: Journal of Clinical Oncology (1999)

PURPOSE: Alternatives to axillary lymph node dissection (ALND) are being developed amid controversy surrounding the therapeutic benefit and overall utility of this routine surgical procedure. Although potential negative side effects associated with ALND are known, we set out to examine whether these side effects contribute significantly to patient reports of quality of life and mental health. PATIENTS AND METHODS: We surveyed 222 women who had received an ALND as part of breast cancer surgery. All women underwent a physical therapy assessment of range of arm/shoulder motion and completed the Modified Post-operative Pain Questionnaire, the Pain Disability Index, the McGill Pain Questionnaire (short form), the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, and the Mental Health Inventory. RESULTS: Seventy-two percent of the women experienced arm/shoulder pain, weakness, or numbness in the week before the interview, and range of motion of the affected arm/shoulder was impaired in 73% of the women. Severity of pain was reported to be low to moderate, and younger patients experienced greater pain than older patients. Pain severity correlated positively with the number of lymph nodes removed and receipt of chemotherapy and was not significantly related to length of time since surgery or receipt of radiation therapy. Generally high levels of cancer-specific quality of life and mental health were reported. Quality of life was significantly predicted by the McGill Pain Questionnaire, and mental health was significantly predicted by the Pain Disability Index and the physical therapy assessment. CONCLUSION: Surgery-related symptoms after ALND persist for a majority of women with breast cancer and are not significantly related to time since surgery or receipt of radiation therapy. These symptoms and associated disability are significantly predictive of cancer-specific quality of life and mental health.
Relationship between knee joint laxity and knee joint mechanics during the menstrual cycle
Authors: S-K Park, D J Stefanyshyn, B Ramage, D A Hart, J L Ronsky
Journal: British Journal of Sports Medicine (2008)

An increase in knee laxity during the menstrual cycle may increase the risk of anterior cruciate ligament injury.To investigate whether changing knee laxity during the menstrual cycle correlates with changing knee joint loads in a cutting manoeuvre.Cross-sectional study.Laboratory testing.25 healthy women, with a normal menstrual cycle, no history of oral contraceptive use, and no previous knee injurySerum hormone concentrations were assessed and knee joint laxity at a load of 89 N was measured during the follicular, ovulation and luteal phases. Participants performed 10 trials of a cutting manoeuvre to quantify knee joint mechanics at each test session.Knee joint laxity (mm), peak knee angle ( degrees ) and knee joint moment (Nm) and knee joint impulse (Nms).Increased knee laxity was observed during ovulation compared with the luteal phase, but no significant changes in knee mechanics corresponding to menstrual phases were found. A positive correlation was found between changes in knee laxity and changes in knee joint loads (Deltamoment or Deltaimpulse) from the follicular phase to ovulation, and from ovulation to the luteal phase (p<0.05). Women in whom knee laxity increased showed increased knee loads, and those in whom knee laxity decreased showed decreased knee loads during the menstrual cycle.Knee laxity correlates positively with knee joint loads, and increased knee laxity during the menstrual cycle may be a potential risk factor for anterior cruciate ligament injuries in certain women during sports activity.
Coronary artery stasis after induced myocardial infarction in the dog
Authors: H. R. Hellstrom
Journal: Cardiovascular Research (1971)

After induced myocardial infarction in the dog, there was marked reduction of flow in the anatomically patent coronary artery supplying the area of infarct. This coronary artery stasis offers a possible mechanism for the secondary development of coronary artery thrombosis after myocardial infarction. Evidence that this flow abnormality was due to vasospasm involving small intramyocardial arteries is presented.
Impaired Distal Thermoregulation in Diabetes and Diabetic Polyneuropathy
Authors: Seward B. Rutkove, Aristidis Veves, Theophano Mitsa, Rui Nie, Patricia M. Fogerson, Lindsay P. Garmirian, Rachel A. Nardin
Journal: Diabetes Care (2009)

OBJECTIVE To determine how thermoregulation of the feet is affected by diabetes and diabetic polyneuropathy in both wakefulness and sleep. RESEARCH DESIGN AND METHODS Normal subjects, diabetic subjects without neuropathy, diabetic subjects with small-fiber diabetic polyneuropathy, and those with advanced diabetic polyneuropathy were categorized based on neurological examination, nerve conduction studies, and quantitative sensory testing. Subjects underwent foot temperature monitoring using an iButton device attached to the foot and a second iButton for recording of ambient temperature. Socks and footwear were standardized, and subjects maintained an activity diary. Data were collected over a 32-h period and analyzed. RESULTS A total of 39 normal subjects, 28 patients with diabetes but without diabetic polyneuropathy, 14 patients with isolated small-fiber diabetic polyneuropathy, and 27 patients with more advanced diabetic polyneuropathy participated. No consistent differences in foot temperature regulation between the four groups were identified during wakefulness. During sleep, however, multiple metrics revealed significant abnormalities in the diabetic patients. These included reduced mean foot temperature (P &amp;lt; 0.001), reduced maximal temperature (P &amp;lt; 0.001), increased rate of cooling (P &amp;lt; 0.001), as well as increased frequency of variation (P = 0.005), supporting that patients with diabetic polyneuropathy and even those with only diabetes but no diabetic polyneuropathy have impaired nocturnal thermoregulation. CONCLUSIONS Nocturnal foot thermoregulation is impaired in patients with diabetes and diabetic polyneuropathy. Because neurons are highly temperature sensitive and because foot warming is part of the normal biology of sleep onset and maintenance, these findings suggest new potentially treatable mechanisms of diabetes-associated nocturnal pain and sleep disturbance.
Involvement of interleukin-17A-induced expression of heat shock protein 47 in intestinal fibrosis in Crohn's disease
Authors: Yusuke Honzawa, Hiroshi Nakase, Masahiro Shiokawa, Takuya Yoshino, Hirotsugu Imaeda, Minoru Matsuura, Yuzo Kodama, Hiroki Ikeuchi, Akira Andoh, Yoshiharu Sakai, Kazuhiro Nagata, Tsutomu Chiba
Journal: Gut (2014)

<h3>Objective</h3> Intestinal fibrosis is a clinically important issue in Crohn9s disease (CD). Heat shock protein (HSP) 47 is a collagen-specific molecular chaperone involved in fibrotic diseases. The molecular mechanisms of HSP47 induction in intestinal fibrosis related to CD, however, remain unclear. Here we investigated the role of interleukin (IL)-17A-induced HSP47 expression in intestinal fibrosis in CD. <h3>Design</h3> Expressions of HSP47 and IL-17A in the intestinal tissues of patients with IBD were determined. HSP47 and collagen I expressions were assessed in intestinal subepithelial myofibroblasts (ISEMFs) isolated from patients with IBD and CCD-18Co cells treated with IL-17A. We examined the role of HSP47 in IL-17A-induced collagen I expression by administration of short hairpin RNA (shRNA) to HSP47 and investigated signalling pathways of IL-17A-induced HSP47 expression using specific inhibitors in CCD-18Co cells. <h3>Results</h3> Gene expressions of <i>HSP47</i> and <i>IL-17A</i> were significantly elevated in the intestinal tissues of patients with active CD. Immunohistochemistry revealed HSP47 was expressed in α-smooth muscle actin (α-SMA)-positive cells and the number of HSP47-positive cells was significantly increased in the intestinal tissues of patients with active CD. IL-17A enhanced HSP47 and collagen I expressions in ISEMFs and CCD-18Co cells. Knockdown of HSP47 in these cells resulted in the inhibition of IL-17A-induced collagen I expression, and analysis of IL-17A signalling pathways revealed the involvement of c-Jun N-terminal kinase in IL-17A-induced HSP47 expression. <h3>Conclusions</h3> IL-17A-induced HSP47 expression is involved in collagen I expression in ISEMFs, which might contribute to intestinal fibrosis in CD.
FDA Regulation of Laboratory-Developed Diagnostic Tests
Authors: Joshua Sharfstein
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effectiveness of Mouse Interferon /beta Compared to Single-Agent Chemotherapy in Increasing Survival Time of Mice After Intravenous Inoculation of Friend Erythroleukemial Cells
Authors: I. Gresser, C. Maury, F. Belardelli, M. -T. Maunoury, D. Machover
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Effectiveness of Mouse Interferon α/β Compared to Single-Agent Chemotherapy in Increasing Survival Time of Mice After Intravenous Inoculation of Friend Erythroleukemial Cells Get access I. Gresser, I. Gresser 3Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le CancerBP 8, 94802 Villejuif, France Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Maury, C. Maury 3Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le CancerBP 8, 94802 Villejuif, France Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Belardelli, F. Belardelli 4Laboratory of Virology, Istituto Superiore di SanitàRome, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar M. -T. Maunoury, M. -T. Maunoury 3Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le CancerBP 8, 94802 Villejuif, France Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Machover D. Machover 5Department of OncologyHôpital Tenon, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 2, 16 March 1988, Pages 126–131, https://doi.org/10.1093/jnci/80.2.126 Published: 16 March 1988 Article history Received: 30 September 1987 Accepted: 25 November 1987 Published: 16 March 1988
Quantitative comparison of the force-interval relationships of the canine right and left ventricles.
Authors: D Burkhoff, D T Yue, M R Franz, W C Hunter, K Sunagawa, W L Maughan, K Sagawa
Journal: Circulation Research (1984)

We quantitatively compared the extrasystolic and postextrasystolic responses of the right ventricle and left ventricle of the same heart, which have vastly different geometries, architectures, and muscle masses. We studied nine isolated, supported canine hearts whose right and left ventricles were made to contract isovolumically with balloons placed in both chambers. The ventricles were paced with the following pattern: 20 regularly timed priming stimulations, followed by a test stimulation at a variable test pulse interval, and, finally, by a second test stimulation which was always delivered 1200 msec after the first test pulse. In each heart, approximately 15 different test pulse intervals between 300 and 1200 msec were investigated. Both the maximum developed pressure and maximum rate of pressure development, expressed as a percentage of their steady state values during the priming period were used to quantify the extra- and postextrasystolic responses. For each extrasystolic and postextrasystolic test beat, the normalized response of the right ventricle was plotted vs. that of the left ventricle. The regression line and correlation coefficient between the two were determined. The average result from nine hearts gave a slope of 0.96 +/- 0.05, an intercept of 4.52 +/- 4.05% and a correlation coefficient of 0.995 +/- 0.004. This analysis indicated that, despite the differences in right and left ventricular geometry, architecture, and mass, their force-interval behaviors were nearly identical.
No age-related decline in efficacy of photodynamic therapy for treatment of basal cell carcinoma
Authors: N.J. Collier, F.R. Ali, J.T. Lear
Journal: British Journal of Dermatology (2015)

Journal Article No age‐related decline in efficacy of photodynamic therapy for treatment of basal cell carcinoma Get access N.J. Collier, N.J. Collier Dermatology Centre Manchester Academic Health Science Centre Salford Royal NHS Foundation Trust University of Manchester Manchester M6 8HD U.K Search for other works by this author on: Oxford Academic Google Scholar F.R. Ali, F.R. Ali Dermatology Centre Manchester Academic Health Science Centre Salford Royal NHS Foundation Trust University of Manchester Manchester M6 8HD U.K Search for other works by this author on: Oxford Academic Google Scholar J.T. Lear J.T. Lear Dermatology Centre Manchester Academic Health Science Centre Salford Royal NHS Foundation Trust University of Manchester Manchester M6 8HD U.K E‐mail: john.lear@cmft.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 6, 1 December 2015, Pages 1564–1565, https://doi.org/10.1111/bjd.14080 Published: 01 December 2015
Languages of thought need to be distinguished from learning mechanisms, and nothing yet rules out multiple distinctively human learning systems
Authors: Michael Tetzlaff, Peter Carruthers
Journal: Behavioral and Brain Sciences (2008)

Abstract We distinguish the question whether only human minds are equipped with a language of thought (LoT) from the question whether human minds employ a single uniquely human learning mechanism. Thus separated, our answer to both questions is negative. Even very simple minds employ a LoT. And the comparative data reviewed by Penn et al. actually suggest that there are many distinctively human learning mechanisms.
Folate, Homocysteine, and Negative Symptoms in Schizophrenia
Authors: Donald C Goff, Teodoro Bottiglieri, Erland Arning, Vivian Shih, Oliver Freudenreich, A Eden Evins, David C Henderson, Lee Baer, Joseph Coyle
Journal: American Journal of Psychiatry (2004)

OBJECTIVE: Because glutamate carboxypeptidase II (GCPII) regulates both folate absorption and activation of N-methyl-d-aspartic acid receptors, the authors examined relationships between serum folate concentrations and clinical symptoms in schizophrenia patients. METHOD: For 91 outpatients with schizophrenia, clinical assessments were performed and serum folate, homocysteine, B12, glycine, and serine concentrations were measured. RESULTS: Serum folate concentrations were significantly lower than in a representative sample from the Framingham Offspring Study. Folate concentration correlated inversely with the Scale for Assessment of Negative Symptoms total score and was lower in patients with the deficit syndrome than in nondeficit patients. Homocysteine concentration correlated with the severity of extrapyramidal symptoms. CONCLUSIONS: These findings could reflect several possible mechanisms, including low dietary intake of folate, low GCPII activity, cigarette smoking, and the involvement of folate in the synthesis of neurotransmitters. Additional studies are needed to clarify these findings.
Nutritional Improvement of Poor Urban Preschool Children
Authors: Paul Zee
Journal: JAMA (1985)

The nutritional status of preschool children from 1,219 families living in an urban poverty area was surveyed in 1983 and these results were compared with findings from a similar survey of the same community done in 1977. A second comparison was made of children whose families participated in a commodity supplementary food program and those whose families did not participate. Results of the 1983 survey indicated improvements in median serum levels of vitamins A and C, hemoglobin, and red blood cell volume. Nevertheless, 9% to 18% of the children had low or deficient levels of vitamins A, C, B1, and B2, hemoglobin, serum iron, and transferrin saturation. Also a greater number of the preschoolers were categorized as thin. Annual incomes for families had significantly decreased from 1977 when the median value for food recipients was +3,078 to a median of +1,848 in 1983. Considering the decrease in other resources, federal food assistance programs seem to be the only identifiable factor contributing to the improvement in nutritional status over 1977.
Molecular confirmation of the unique phenotype of epidermolysis bullosa simplex with mottled pigmentation
Authors: A.D. Irvine, E.L. Rugg, E.B. Lane, S. Hoare, C. Peret, A.E. Hughes, A.H. Heagerty
Journal: British Journal of Dermatology (2001)

A distinctive subtype of epidermolysis bullosa simplex, with the additional feature of mottled pigmentation (EBS-MP), was initially characterized in a Swedish family in 1979, and seven further families have been reported. Features of EBS-MP that are observed in most affected patients include acral blistering early in childhood, mottled pigmentation distributed in a number of sites, focal punctate hyperkeratoses of the palms and soles, and dystrophic, thickened nails. The genetic basis of EBS-MP has been ascribed in five unrelated families to a heterozygous point mutation, P25L, in the non-helical V1 domain of K5.We report a clinical, ultrastructural and molecular study of two of the earliest families to be clinically characterized as EBS-MP.The P25L mutation was identified in all affected members of each of these families, bringing the total number of EBS-MP families with this mutation to seven.This unusual recurrent mutation may uniquely cause EBS-MP.While the exact molecular mechanisms by which this mutation causes epidermolysis, palmoplantar keratoderma and pigmentation remain elusive, we suggest possible molecular mechanisms through which the P25L substitution could cause this unusual phenotype.
A randomised controlled trial of intra-articular corticosteroid injection of the carpometacarpal joint of the thumb in osteoarthritis
Authors: G K Meenagh
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objective:</b> To investigate the efficacy of corticosteroid injections into the carpometacarpal joint of the thumb (CMCJ) in patients with osteoarthritis. <b>Design:</b> A double blind, randomised controlled trial using 40 hospital referred patients with CMCJ osteoarthritis who received intra-articular injections of 5 mg triamcinolone hexacetonide (0.25 ml) or sterile 0.9% saline (0.25 ml). Injections were given under imaging control. <b>Main outcome measures:</b> The primary outcome was improvement in a pain visual analogue score (VAS) of 20% at 24 weeks. In addition patients were assessed at 4, 12, and 24 weeks for joint stiffness, joint tenderness, and physician and patient global assessments. Hand radiographs were evaluated for the degree of CMC joint space narrowing and marginal osteophytes according to the OARSI atlas. <b>Results:</b> Baseline clinical variables were not significantly different between the two treatment groups. There was no improvement in the VAS of pain at 24 weeks. At each assessment point there was no significant difference between the steroid and placebo groups in median values for joint stiffness, joint tenderness, or patient and physician global assessments. Non-parametric analysis of each group individually revealed statistically significant improvements in patient and physician global assessments at weeks 4, 12, and 24 in the placebo group and at weeks 4 and 12 in the steroid group. <b>Conclusions:</b> No clinical benefit was gained from intra-articular steroid injection to the CMCJ in moderate to severe osteoarthritis compared with placebo injection.
Mycophenolate Mofetil versus Cyclosporin A in Children with Frequently Relapsing Nephrotic Syndrome
Authors: Jutta Gellermann, Lutz Weber, Lars Pape, Burkhard Tönshoff, Peter Hoyer, Uwe Querfeld
Journal: Journal of the American Society of Nephrology (2013)

The severe side effects of long-term corticosteroid or cyclosporin A (CsA) therapy complicate the treatment of children with frequently relapsing steroid-sensitive nephrotic syndrome (FR-SSNS). We conducted a randomized, multicenter, open-label, crossover study comparing the efficacy and safety of a 1-year treatment with mycophenolate mofetil (MMF; target plasma mycophenolic acid trough level of 1.5-2.5 µg/ml) or CsA (target trough level of 80-100 ng/ml) in 60 pediatric patients with FR-SSNS. We assessed the frequency of relapse as the primary endpoint and evaluated pharmacokinetic profiles (area under the curve [AUC]) after 3 and 6 months of treatment. More relapses per patient per year occurred with MMF than with CsA during the first year (P=0.03), but not during the second year (P=0.14). No relapses occurred in 85% of patients during CsA therapy and in 64% of patients during MMF therapy (P=0.06). However, the time without relapse was significantly longer with CsA than with MMF during the first year (P<0.05), but not during the second year (P=0.36). In post hoc analysis, patients with low mycophenolic acid exposure (AUC <50 µg⋅h/ml) experienced 1.4 relapses per year compared with 0.27 relapses per year in those with high exposure (AUC>50 µg⋅h/ml; P<0.05). There were no significant differences between groups with respect to BP, growth, lipid levels, or adverse events. However, cystatin clearance, estimated GFR, and hemoglobin levels increased significantly with MMF compared with CsA. These results indicate that MMF is inferior to CsA in preventing relapses in pediatric patients with FR-SSNS, but may be a less nephrotoxic treatment option.