tbuckley/cabot-search huggingface dataset:
Migratory potential and influence on neoangiogenesis of rheumatoid arthritis synovial fibroblasts
Authors: B Zimmermann, S Lefevre, S Fischer, J Gansler, A Lehr, S Rehart, H Sturz, J Steinmeyer, U Muller-Ladner, E Neumann
Journal: Annals of the Rheumatic Diseases (2010)

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease including joint destruction that is characterised by starting in single joints and then spreading to non-affected joints. We recently demonstrated the long-distance migratory behavior of RA synovial fibroblasts (SF) via the blood stream and the invasion of distant cartilage in the SCID mouse model of RA. The mechanisms of the endothelial transmigration of …
Methysergide-induced scleroderma-like changes of the legs
Authors: N. Kluger, C. Girard, D. Bessis, B. Guillot
Journal: British Journal of Dermatology (2005)

Conflicts of interest: none declared. Sir, Methysergide is a semisynthetic ergot alkaloid ergometrine derivative, acting as a serotonin receptor antagonist, used in migraine prophylaxis. Common reported side‐effects include cardiac and arterial vasospastic symptoms and systemic fibrosis, mainly retroperitoneal. We describe the first case, to our knowledge, of methysergide‐associated scleroderma‐like changes of the legs. A 63‐year‐old woman presented with a 2‐month history of inflammatory oedema of the legs and feet. Her medical history included: (i) migraine treated with methysergide 1·65 mg daily, which she had taken continuously for more than 10 years; (ii) depression treated with lorazepam 5 mg daily for 5 years; (iii) breast carcinoma treated 3 years previously by tumorectomy, lymphadenectomy, chemotherapy and radiotherapy; since then, she had been taking tamoxifen 20 mg daily and had so far remained in remission; (iv) gastritis treated with esomeprazole 20 mg daily for 2 years; and (v) hypercholesterolaemia treated with pravastatin 20 mg daily for 2 years.
The neuropsychiatric disorder in systemic lupus erythematosus: evidence for both vascular and immune mechanisms.
Authors: B Bresnihan, R Hohmeister, J Cutting, R L Travers, M Waldburger, C Black, T Jones, G R Hughes
Journal: Annals of the Rheumatic Diseases (1979)

As part of a prospective survey of systemic lupus erythematosus (SLE) a detailed collaborative study of the clinical, psychiatric, and laboratory features in 15 patients with nonfocal neuropsychiatric disease has been undertaken. In addition to conventional clinical and psychometric evaluation, electroencephalograph, and cerebrospinal fluid analysis, the study included the assessment of cerebral blood flow with oxygen-15 brain scans and serological testing for the presence of antineuronal and lymphocytotoxic antibodies. Of the 15 patients 12 had psychiatric manifestations, while 13 had various neurological abnormalities. All except 2 episodes of cerebral disease were transient. Striking abnormalities in cerebral blood flow and metabolism were seen in 12 patients, even in the presence of subtle clinical features. Sequential scans showed that improvement in clinical features was accompanied by a reversal of scan abnormalities. All sera contained brain-reactive antibody, either antineuronal IgG antibody (13) or lymphocytotoxic IgM antibody (12) or both (10), though there was an inconsistent association between clinical features and antibody titre. It is suggested that transient disturbances of cerebral vascular function in SLE might allow brain-reactive antibodies from the circulation access to cerebral tissue. In this way the nature of the neuropsychiatric abnormalities would depend on both vascular and immunopathogenic mechanisms.
Interphase FISH screening for the LCR-mediated common rearrangement of isochromosome 17q in primary myelofibrosis
Authors: Gabriel A. Bien-Willner, Paweł Stankiewicz, James R. Lupski, Jill K. Northup, Gopalrao V.N. Velagaleti
Journal: American Journal of Hematology (2005)

Non-allelic homologous recombination (NAHR) between low-copy repeats (LCRs) has been implicated recently in somatic rearrangements including isochromosome i(17q), which is associated with hematologic malignancies as well as solid tumors.In hematological malignancies, the most common i(17q) breakpoint results from LCR-mediated NAHR, which creates a dicentric chromosome, idic(17)(p11.2).We report an elderly patient who presented with primary myelofibrosis (MF) with myeloid metaplasia (MMM), associated with idic(17)(p11.2) as the sole chromosomal abnormality, making this the first idic(17)(p11.2)myeloproliferative case reported in which the breakpoints are mapped to the breakpoint cluster region in proximal 17p.The rearrangement breakpoint maps to the previously defined LCR cluster, further suggesting that the genomic architecture of proximal 17p may be responsible for the formation of the majority of i(17q) cases.We describe our development of a rapid screening test using interphase FISH to detect idic(17)(p11.2),discuss the potential prognostic value of this molecular diagnostic test, and examine the relevance of LCRmediated NAHR to common rearrangements in neoplasms.
School age outcome of hospitalisation with respiratory syncytial virus infection of prematurely born infants
Authors: A Greenough, J Alexander, P Boit, J Boorman, S Burgess, A Burke, P A Chetcuti, I Cliff, W Lenney, T Lytle, C Morgan, C Raiman, N J Shaw, K P Sylvester, J Turner
Journal: Thorax (2009)

<h3>Background:</h3> Hospitalisation due to respiratory syncytial virus (RSV) infection in the first 2 years after birth has been associated with increased healthcare utilisation and associated costs up to 5 years of age in children born prematurely at less than 32 weeks of gestation who developed bronchopulmonary dysplasia (BPD). A study was undertaken to determine whether hospitalisation due to RSV infection in the first 2 years was associated with increased morbidity and lung function abnormalities in such children at school age, and if any effects were influenced by age. <h3>Methods:</h3> Healthcare utilisation and cost of care in years 5–7 were reviewed in 147 children and changes in healthcare utilisation between 0 and 8 years were assessed also using results from two previous studies. At age 8–10 years, 77 children had their lung function assessed and bronchial hyper-responsiveness determined. <h3>Results:</h3> Children hospitalised with RSV infection (n = 25) in the first 2 years had a greater cost of care related to outpatient attendance than those with a non-respiratory or no admission (n = 72) when aged 5–7 years (p = 0.008). At 8–10 years of age, children hospitalised with RSV infection (n = 14) had lower forced expiratory volume in 0.75 s (FEV<sub>0.75</sub>) (p = 0.015), FEV<sub>0.75</sub>/forced vital capacity (p = 0.027) and flows at 50% (p = 0.034) and 75% (p = 0.006) of vital capacity than children hospitalised for non-RSV causes (n = 63). Healthcare utilisation decreased with increasing age regardless of RSV hospitalisation status. <h3>Conclusions:</h3> In prematurely born children who had BPD, hospitalisation due to RSV infection in the first 2 years is associated with reduced airway calibre at school age.
Prognostic value of the soluble interleukin-2 receptor in chronic hepatitis C treated with interferon-alfa
Authors: Sylvie Naveau, Axel Balian, Françoise Degos, Véronique Daurat, Sylvie Chevret, Sophie Gayno, Anne Bastie, Ghassan Riachi, Isabelle Bartolomei-Portal, Karl Barange, Joseph Moussalli, François Bailly, Philippe Chaumet-Riffaud, Dominique Emilie
Journal: Journal of Hepatology (1999)
Complete cleft sternum.
Authors: R K Firmin, L S Fragomeni, S C Lennox
Journal: Thorax (1980)

A case of complete cleft sternum is presented along with the nomenclature of sternal defects. It is recommended that the term ectopia cordis should be applied only to cases in which the heart and thoracic viscera are genuinely ectopic. Surgical correction of complete cleft sternum should be performed in the neonatal period whether the infant is symptomatic or not. Simple closure of the defect, as for a median sternotomy, is possible during the first month of life and this avoids the more complex reconsructions necessary in older children.
Stem Cells in the Treatment of Heart Disease
Authors: Stefan Janssens
Journal: Annual Review of Medicine (2010)

Progenitor cells residing in bone marrow, adipose tissue, and skeletal muscle or circulating in the blood are capable of improving myocardial function in preclinical models. In contrast, early clinical studies using bone marrow cells have shown mixed results and reflect our incomplete understanding of underlying mechanisms. Recent identification of various cardiac precursor cells has suggested an endogenous reservoir for cell-based repair. However, confronted with massive cardiac cell loss, inventive strategies and enabling technologies are required to mobilize or deliver functionally competent progenitor cells to sites of injury or to effectively stimulate endogenous repair. We review our present knowledge in this promising and rapidly evolving development in cardiovascular medicine and highlight obstacles as well as opportunities.
Real-time Monitoring of<i>In Vivo</i>Acute Necrotic Cancer Cell Death Induced by Near Infrared Photoimmunotherapy Using Fluorescence Lifetime Imaging
Authors: Takahito Nakajima, Kohei Sano, Makoto Mitsunaga, Peter L. Choyke, Hisataka Kobayashi
Journal: Cancer Research (2012)

A new type of monoclonal antibody (mAb)-based, highly specific phototherapy (photoimmunotherapy; PIT) that uses a near infrared (NIR) phthalocyanine dye, IRDye700DX (IR700) conjugated with a mAb, has recently been described. NIR light exposure leads to immediate, target-selective necrotic cell death in vitro. Detecting immediate in vivo cell death is more difficult because it takes at least 3 days for the tumor to begin to shrink in size. In this study, fluorescence lifetime (FLT) was evaluated before and after PIT for monitoring the immediate cytotoxic effects of NIR mediated mAb-IR700 PIT. Anti-epidermal growth factor receptor (EGFR) panitumumab-IR700 was used for targeting EGFR-expressing A431 tumor cells. PIT with various doses of NIR light was conducted in cell pellets in vitro and in subcutaneously xenografted tumors in mice in vivo. FLT measurements were obtained before and 0, 6, 24, and 48 hours after PIT. In vitro, PIT at higher doses of NIR light immediately led to FLT shortening in A431 cells. In vivo PIT induced immediate shortening of FLT in treated tumors after a threshold NIR dose of 30 J/cm(2) or greater. In contrast, lower levels of NIR light (10 J/cm(2) or smaller) did not induce shortening of FLT. Prolongation of FLT in tissue surrounding the tumor site was noted 6 hours after PIT, likely reflecting phagocytosis by macrophages. In conclusion, FLT imaging can be used to monitor the acute cytotoxic effects of mAb-IR700-induced PIT even before morphological changes can be seen in the targeted tumors.
Genome Sequencing of Multiple Primary Tumors Reveals a Novel <i>PALB2</i> Variant
Authors: Kasmintan A. Schrader, Kelly L. Stratton, Rajmohan Murali, Yael Laitman, Luca Cavallone, Lily Offit, Yong Hannah Wen, Tinu Thomas, Sohela Shah, Rohini Rau-Murthy, Christopher Manschreck, Erin Salo-Mullen, Ebun Otegbeye, Marina Corines, Liying Zhang, Larry Norton, Clifford Hudis, Robert J. Klein, Noah D. Kauff, Mark Robson, Zsofia K. Stadler, Daniel A. Haber, Steven M. Lipkin, Eitan Friedman, William D. Foulkes, David Altshuler, Joseph Vijai, Kenneth Offit
Journal: Journal of Clinical Oncology (2014)
Improvement with long-term itraconazole therapy for Fonsecaea pedrosoi-related mediastinal phaeohyphomycosis
Authors: N. Singh, R. Agarwal, D. Gupta
Journal: European Respiratory Journal (2008)

We thank D. Stanescu for his interest in our paper [1] and for giving us the opportunity to clarify an important methodological issue.First of all, we would like it to be remembered that our document was intended for use in designing clinical trials on pharmacological treatments of chronic obstructive pulmonary disease.The point we wanted to make clear is that, because of the well known potential errors inherent to dilution methods and body plethysmography [2-4], they should not be used interchangeably within a clinical trial.We are aware that keeping the panting frequency below 1 Hz helps reduce overestimation of lung volumes measured by body plethysmography in the presence of airflow obstruction [5,6], but this has to be confirmed in very severe chronic obstructive pulmonary disease and it may not be easily feasible in large multicentre clinical trials.Notwithstanding, we agree that, whenever possible, the plethysmographic method should be adopted, not only because it is less time consuming, but also because it allows assessment of repeatability of measurements within sessions and, thus, better quality control.
X-RAY DERMATITIS AND EPITHELIOMA
Authors: J. L. BUNCH
Journal: British Journal of Dermatology (1910)

Journal Article X‐RAY DERMATITIS AND EPITHELIOMA Get access J. L. BUNCH, M.D., D.Sc. J. L. BUNCH, M.D., D.Sc. Physician in Charge of the Skin‐Department, Queen's Hospital for Children Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 22, Issue 11, 1 November 1910, Pages 339–344, https://doi.org/10.1111/j.1365-2133.1910.tb16596.x Published: 01 November 1910
Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway
Authors: Zhong Q. Wang, Xian H. Zhang, Yongmei Yu, Russell C. Tipton, Ilya Raskin, David Ribnicky, William Johnson, William T. Cefalu
Journal: Metabolism (2013)
Serum uric acid in England and Scotland.
Authors: R A Sturge, J T Scott, A C Kennedy, D P Hart, W W Buchanan
Journal: Annals of the Rheumatic Diseases (1977)

Serum uric acid (SUA) was measured in 512 men and 254 women from two English regions and in 337 men from one Scottish region. Mean SUA levels were the same in the men (5-5 mg/100 ml) and similar in the women (3-9 and 4-1 mg/100 ml). The apparent rarity of gout in Scotsmen cannot be explained by regional differences in SUA levels or in the prevalence of hyperuricaemia (defined as SUA of 7-0 mg/100 ml or over) which was present in 6-6% of the English men and 8% of the Scots. SUA was positively correlated with weight and serum urea, and with age in women, but no variation was found with social class. Body weight was the most important predictor of SUA in both men and women and superior to measurements involving correction for height, such as ponderal index and calculated lean body mass.
Radiological Evaluation Of Velopharyngeal Closure
Authors: M. Leon Skolnick
Journal: JAMA (1971)

<h3>To the Editor.—</h3> We wish to add some remarks to the reports (<b>216</b>:2075, 1971) of papers presented by Hogan and Zaborsky at the plastic surgery meeting in Williamsburg, Va, concerned with the success and failure of pharyngeal flaps in eliminating nasality in patients with cleft palate. To achieve velopharyngeal closure, a pharyngeal flap must occupy the space between the lateral pharyngeal walls at their maximum medial movement during phonation. Flap width must be related to the degree of movement of the lateral pharyngeal walls and, therefore, should be individually tailored to the patient. A patient with very active lateral walls and a mobile palate needs a narrow flap, while a subject with poor lateral wall movement needs a wide flap. If the lateral walls exhibit no motion a flap may not be the best treatment. Instead, methods of mechanically stimulating the lateral walls should first be used in an
Reintroducing “Reintroducing group selection to the human behavioral sciences”to BBS readers
Authors: Nicholas S. Thompson
Journal: Behavioral and Brain Sciences (1998)

Wilson and Sober's (1994t) revival of group selection theory may have failed with some readers because its simple arithmetic foundation was obscured under the complexities of its presentation. When that uncontrovertible principle is uncovered, it broadens dramatically the fundamental motives that social scientists may impute to human nature and still be consistent with Darwinian evolutionary theory.
Human Leukocyte Antigen-G Protein Expression Is an Unfavorable Prognostic Predictor of Hepatocellular Carcinoma following Curative Resection
Authors: Ming-Yan Cai, Yong-Feng Xu, Shuang-Jian Qiu, Min-Jie Ju, Qiang Gao, Yi-Wei Li, Bo-Heng Zhang, Jian Zhou, Jia Fan
Journal: Clinical Cancer Research (2009)

Human leukocyte antigen-G (HLA-G) is a tumor-associated immunosuppressive molecule involved in tumor escape mechanisms. The aim of this study is to elucidate its prognostic significance in hepatocellular carcinoma (HCC).Immunohistochemical staining of HLA-G expression as well as tumor-infiltrating FoxP3+ regulatory (Tregs) and CD8+ cytotoxic T cells was carried out on tissue microarrays containing 173 HCC tissue specimens. Membrane-bound HLA-G1 protein expression in five human HCC cell lines was detected by Western blot.HLA-G expression was associated with HCC prognosis, especially in early-stage diseases, with high expression independently associated with shortened overall survival (P = 0.041) and increased tumor recurrence (P = 0.023). HLA-G level was positively related to Tregs/CD8+ ratio and their combination served as a better prognosticator, patients having concurrent high levels of both variables at more than three times of risk of death and tumor relapse than those with concurrent low levels (both P < 0.001). In addition, HLA-G1 expression increased in a concordant manner with the increase of metastatic potential in human HCC cell lines.Overexpression of HLA-G protein in HCC was an independent indicator for poor outcome especially in early-stage disease. The combination of HLA-G expression and Tregs/CD8+ ratio added the prognostic power to both variables, offering a possible strategy of tumor-stroma interaction-oriented cancer immunotherapy.
American Joint Committee on Cancer Staging System Does Not Accurately Predict Survival in Patients Receiving Multimodality Therapy for Esophageal Adenocarcinoma
Authors: Nabil P. Rizk, Ennapadam Venkatraman, Manjit S. Bains, Bernard Park, Raja Flores, Laura Tang, David H. Ilson, Bruce D. Minsky, Valerie W. Rusch
Journal: Journal of Clinical Oncology (2007)

Purpose In patients with adenocarcinoma of the esophagus who receive preoperative chemoradiotherapy (CRT), American Joint Committee on Cancer (AJCC) stage, pathologic complete response (pCR), and estimated treatment response are various means used to stratify patients prognostically after surgery. However, none of these methods has been formally evaluated. The purpose of this study was to establish prognostic pathologic variables after CRT. Patients and Methods A retrospective review was performed of patients with esophageal adenocarcinoma who received CRT before esophagectomy. Data collected included demographics, CRT details, pathologic findings, and survival. Statistical methods included recursive partitioning and Kaplan-Meier analyses. Results Two hundred seventy-six patients were appropriate for this analysis. Kaplan-Meier analysis indicates that the current AJCC system poorly distinguishes between stages 0 to IIA (P = .52), IIB to III (P = .87), and IVA to IVB (P = .30). The presence of a pCR conferred improved survival over residual disease (P = .01). Recursive partitioning analysis indicates that involved lymph nodes and metastatic disease are the best predictors of survival and that depth of invasion and degree of treatment response are less predictive. Conclusion The current AJCC staging system is not a good predictor of survival after CRT. Although patients with a pCR do have improved long-term survival relative to patients with residual disease, this method places too much emphasis on residual depth of invasion and fails to identify patients with residual disease who have good long-term survival. Recursive partitioning analysis more accurately identifies nodal disease and metastatic disease as the most important prognostic variables. Degree of treatment response is less prognostic than nodal involvement.
Effects of a Novel Long Noncoding RNA, lncUSMycN, on N-Myc Expression and Neuroblastoma Progression
Authors: Pei Y Liu, Daniela Erriquez, Glenn M Marshall, Andrew E Tee, Patsie Polly, Mathew Wong, Bing Liu, Jessica L Bell, Xu D Zhang, Giorgio Milazzo, Belamy B Cheung, Archa Fox, Alexander Swarbrick, Stefan Hüttelmaier, Maria Kavallaris, Giovanni Perini, John S Mattick, Marcel E Dinger, Tao Liu
Journal: JNCI Journal of the National Cancer Institute (2014)

Background Patients with neuroblastoma due to the amplification of a 130-kb genomic DNA region containing the MYCN oncogene have poor prognoses.
Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-A.
Authors: A G Rolink, S T Pals, E Gleichmann
Journal: The Journal of Experimental Medicine (1983)

By induction of a graft-vs.-host reaction (GVHR) in nonirradiated H-2-different F1 mice, one can induce stimulatory pathological symptoms, such as lymphadenopathy and hypergammaglobulinemia, combined with the production of autoantibodies characteristic of systemic lupus erythematosus (SLE). Alternatively, the GVHR can lead to the suppressive pathological symptoms, such as pancytopenia and hypogammaglobulinemia, characteristic of acute GVH disease (GVHD). Whether stimulatory or suppressive symptoms are induced by a GVHR depends, in our view (2-4), on the functional subset of donor T cells activated in the F1 host. The purpose of the present study was to investigate whether class I and/or class II H-2 alloantigens can selectively trigger, out of a pool of unselected donor T cells, those subpopulations of T cells responsible for the stimulatory and suppressive GVH symptoms, respectively. For the induction of the GVHR, 10(8) lymphoid cells from C57BL/6 (B6) donors were injected into three kinds of F1 hybrid mice, which had been bred from H-2 mutant strains on a B6 background. Whereas the I-A-disparate (B6 X bm12)F1 recipients exclusively developed stimulatory GVH symptoms, including SLE-like autoantibodies and immune complex glomerulonephritis, the K locus-disparate (B6 X bm1)F1 recipients showed neither clearly stimulatory nor clearly suppressive GVH symptoms. In marked contrast, the (bm1 X bm12)F1 recipients, which differ from the B6 donor strain by mutations at both K and I-A locus, initially developed stimulatory GVH symptoms, but rapidly thereafter showed the suppressive pathological symptoms of acute GVHD and died. Moreover, spleen cells obtained from (B6 X bm12)F1 mice injected with B6 donor cells helped the primary anti-sheep erythrocyte (SRBC) response of normal (B6 X bm12)F1 spleen cells in vitro, whereas spleen cells (bm1 X bm12)F1 mice injected with B6 donor cells strongly suppressed the primary anti-SRBC response of normal (bm1 X bm12)F1 spleen cells. Spleen cells from the K locus-disparate (B6 X bm1)F1 recipients also suppressed the primary anti-SRBC of normal (B6 X bm1)F1 spleen cells; this suppression, however, was weak when compared with the suppression induced by spleen cells from GVH (bm1 X bm12)F1 mice. Taken together, these findings indicate that a small class II (I-A) antigenic difference suffices to trigger the alloreactive donor T helper cells causing SLE-like GVHD. In contrast, both class I (H-2K) and class II (I-A) differences are required to trigger the subsets of donor T cells responsible for acute GVHD. It appears that alloreactive donor T helper cells induce the alloreactive T suppressor cells, which then act as the suppressor effector cells causing the pancytopenia of acute GVHD. These findings may help to understand the variability of GVH-like diseases caused by a given etiologic agent, their cellular pathogenesis, and association with certain HLA loci.