tbuckley/cabot-search huggingface dataset:
Huntingtin-Interacting Protein-1 Is an Early-Stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated Epithelial–Mesenchymal Transition
Authors: Che-Yu Hsu, Cheng-Han Lin, Yi-Hua Jan, Chia-Yi Su, Yun-Chin Yao, Hui-Chuan Cheng, Tai-I Hsu, Po-Shun Wang, Wen-Pin Su, Chih-Jen Yang, Ming-Shyan Huang, Marcus J. Calkins, Michael Hsiao, Pei-Jung Lu
Journal: American Journal of Respiratory and Critical Care Medicine (2015)

Non-small cell lung cancer (NSCLC) carries a poor survival rate mainly because of metastasis. However, the molecular mechanisms that govern NSCLC metastasis have not been described. Because huntingtin-interacting protein-1 (HIP1) is known to play a role in tumorigenesis, we tested the involvement of HIP1 in NSCLC progression and metastasis.HIP1 expression was measured in human NSCLC tumors, and correlation with survival outcome was evaluated. Furthermore, we investigated the ability of HIP1 to suppress metastasis. The molecular mechanism by which HIP1 contributes to suppress metastasis was investigated.We used tissue arrays containing samples from 121 patients with NSCLC to analyze HIP1 expression by immunohistochemistry. To investigate the role of HIP1 expression on metastasis, we evaluated cellular mobility, migration, and invasion using lung adenocarcinoma (AdCA) cells with modified HIP1 expression levels. The human disease mouse models with the same cells were applied to evaluate the HIP1 suppressing metastasis and its mechanism in vivo.HIP1 expression in AdCA progression was found to be an early-stage prognostic biomarker, with low expression correlated to poor prognosis. We also found HIP1 to be a metastatic suppressor in AdCA. HIP1 significantly repressed the mobility of lung cancer cells in vitro and in vivo and regulated the epithelial-mesenchymal transition by repressing AKT/glycogen synthase kinase-3β/β-catenin signaling.HIP1 serves as an early-stage prognostic biomarker and a metastatic suppressor. Reduced expression during AdCA progression can relieve HIP1 suppression of Akt-mediated epithelial-mesenchymal transition and thereby lead to development of late metastases and poor prognosis.
Events Reported to a 24 Hour Helpline for Food Allergic Reaction Treatment Advice in Children Prescribed Epinephrine Auto-Injectors: Randomised Controlled Trial
Authors: Jonathan O. Hourihane, Maeve M. Kelleher, Audrey Dunn Galvin, Claire Cullinane, John Fitzsimons, Aziz Sheikh
Journal: Journal of Allergy and Clinical Immunology (2013)
Risks Associated With Catheters
Authors: Kenneth E. Covinsky
Journal: JAMA Internal Medicine (2015)

Jerome A. Leis, MD, MSc; Carla Corpus, RN, CIC; Armin Rahmani; Barbara Catt, CIC; Brian M. Wong, MD; Sandra Callery, RN, MHSc, CIC; Mary Vearncombe, MD
Evaluation of clinical competence in medical oncology training programs.
Authors: J H Glick, B A Chabner, J A Benson
Journal: Journal of Clinical Oncology (1988)

The American Board of Internal Medicine (ABIM) has asked that directors of medical oncology training programs establish systems to evaluate, document, and substantiate the clinical competence of subspecialty trainees who seek certification. The Board defines the certificable medical oncologist at the completion of training as being competent to provide comprehensive and specialized medical care based on a high standard of demonstrated component skills. These skills clearly exceed those demonstrated by the certified internist. The goal of this expanded evaluation program is to ensure that the public and the profession can identify, through certification, physicians capable of providing a high standard of medical care.
Predicting pre-eclampsia
Authors: Lucy C Chappell, Jane Sandall, Ann Marie Barnard, Richard J McManus
Journal: BMJ (2015)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Predicting pre-eclampsia Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
CLINICAL AND ANATOMICAL ANALYSIS OF TWO CASES OF MULTIPLE SCLEROSIS
Authors: LAWSON G. LOWREY
Journal: American Journal of Psychiatry (1918)

1. A man whose trouble began with a "shock" at 26, who had numerous convulsions through a period of years and whose neurological symptoms varied from time to time, showed at autopsy an area of gliosis in the left parietal lobe, together with patchy gliosis in the cord. His condition had been diagnosed syphilitic dementia, brain tumor, multiple sclerosis and epilepsy. 2. A girl of 19, previously immoral, was found to have spinal fluid changes such as are found in neurosyphilis (except that the Wassermann test was negative), together with marked and varying neurological symptoms. The autopsy showed a meningitis of mild grade, together with an extremely pronounced multiple sclerosis. 3. The relationship between the neurosyphilis (?) and the sclerosis is obscure. 4. They may stand in the relation of cause and effect, or they may be coincident, or both meningitis and sclerosis may be due to some other cause. 5. Two unusual combinations of lesions are presented: A. Large focal lesion of cortical gray matter in multiple sclerosis. B. Combination of meningitis and multiple sclerosis.
Asymptomatic anal sexually transmitted infections in HIV-positive men attending anal cancer screening
Authors: W. Fuchs, A. Kreuter, M. Hellmich, A. Potthoff, J. Swoboda, N.H. Brockmeyer, U. Wieland
Journal: British Journal of Dermatology (2015)

HIV-positive men who have sex with men (HIV+MSM) have an increased risk for anal dysplasia and for sexually transmitted infections (STIs).We determined the positivity rates of Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), Mycoplasma genitalium (MG) and syphilis in HIV+MSM participating in an anal cancer screening programme.In total, 852 intra-anal swabs were collected from 503 HIV+MSM between 2012 and 2014. Anal cytology and polymerase chain reaction assays for human papillomavirus (HPV), CT, NG and MG detection were performed. The syphilis status was determined serologically. Risk factors for STIs were explored by multiple logistic regression analysis.In total 20·7% (104 of 503) of the patients had an STI other than HPV within the study period. The most common was CT, found in 10·9%, followed by NG (8·9%) and MG (4·2%). Early syphilis was detected in 4·6% and past syphilis in 44·5% of the HIV+MSM. Eighteen patients (3·6%) had more than one STI episode, and 90·6% of the 127 cases of STIs were asymptomatic. Age, anal HPV infection, abnormal anal cytology and previous syphilis were risk factors for STI.Anal STIs are frequent and mostly asymptomatic in HIV+MSM participating in anal cancer screening. STI screening should be incorporated into anal cancer screening programmes for HIV+MSM.
Pharmacokinetics and Pharmacodynamics of NPH Insulin in Type 1 Diabetes: The Importance of Appropriate Resuspension Before Subcutaneous Injection
Authors: Paola Lucidi, Francesca Porcellati, Anna Marinelli Andreoli, Ilaria Carriero, Paola Candeloro, Patrizia Cioli, Geremia B. Bolli, Carmine G. Fanelli
Journal: Diabetes Care (2015)

OBJECTIVE Crystalline NPH insulin comes in a two-phase solution with either a solvent or a rapid-acting insulin (in premixed formulations) and needs adequate mixing for complete resuspension before injection. The aim of this study was to establish pharmacokinetics (PK) and pharmacodynamics (PD) after injection of appropriately resuspended versus nonresuspended NPH insulin. RESEARCH DESIGN AND METHODS PK and PD were assessed after subcutaneous injection of NPH insulin 0.35 units/kg at steady state by pen either resuspended (R+, tipping of insulin pen 20 times) or nonresuspended (pen maintained in fixed position either horizontally [R- horizontal] or vertically with tip up [R- up] or tip down [R- down]). Eleven subjects with type 1 diabetes (age 31.5 ± 12 years, diabetes duration 17.5 ± 7.7 years, BMI 22.9 ± 1.5 kg/m2, A1C 7.2 ± 0.4% [55.2 ± 4.4 mmol/mol]) were studied (euglycemic clamp) with a randomized crossover design. RESULTS Compared with resuspended NPH insulin (R+), nonresuspended NPH insulin resulted in profound PK/PD differences with either reduced (R- horizontal and R- up) or increased (R- down) plasma insulin concentrations [FIRI_AUC(0–end of study) (free immunoreactive insulin area under the concentration-time curve between 0 and end of study)] and PD activity [glucose infusion rate (GIR)_AUC(0–end of study)] (all P &amp;lt; 0.05). Duration of NPH insulin action was shorter in R- up (9.4 ± 1.7 h) but longer in R- down (15.4 ± 2.3 h) compared with R+ (11.8 ± 2.6 h) (P &amp;lt; 0.05). Within-subject variability (percent coefficient of variation) among studies was as high as 23% for PK [FIRI_AUC(0–end of study)] and 62% for PD [GIR_AUC(0–end of study)]. CONCLUSIONS Compared with resuspended NPH insulin, lack of resuspension profoundly alters PK/PD and may importantly contribute to day-to-day glycemic variability of type 1 diabetes.
Trial was wrong to ignore other sinuses
Authors: D. J Gatland
Journal: BMJ (1995)

emphasis on the health benefits of activity of moderate intensity.'The Northern Ireland health and activity survey, a cross section survey of 1600 subjects aged 16-74 in Northern Ireland, found that 18% of men and 16% of women, achieved moderate activity of 20 minutes' duration in a four week period through cycling.2Thirty one per cent of men and 20% of women aged 16-34 had cycled to this level.Of those aged 35-54, 10% of men and 13% of women were active to this level through cycling, while among those aged 55-74 the proportions had fallen to 5% and 3% respectively.Of all forms of sport and recreation, cycling was one of those most often recorded in the four week period, in the previous year, and since the age of 14; overall, 37% of men and 26% of women had cycled in the previous year and 53% of men and 36% of women had cycled on some occasion since the age of 14.Clearly, there are opportunities for using cycling as a foundation for an improvement in population levels of physical activity.
Erratum to: miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer
Authors: Helong Zhao, Tasha Wilkie, Yadwinder Deol, Amita Sneh, Akaansha Ganju, Mustafa Basree, Mohd W. Nasser, Ramesh K. Ganju
Journal: Molecular Cancer (2015)

Erratum

After publication of [1] it came to the authors’ attention that in the abstract. The sentence “In the present study, we show that S100A7 significantly downregulates the expression of miR-29b in Estrogen Receptor (ER)-positive breast cancer cells (represented by MCF7), and significantly upregulates miR-29b in ER-negative cells (represented by MDA-MB-231)”. Was Incorrect, the correct statement is “In the present study, we show that S100A7 significantly upregulates the expression of miR-29b in Estrogen Receptor (ER)-positive breast cancer cells (represented by MCF7), and significantly downregulates miR-29b in ER-negative cells (represented by MDA-MB-231)”.
Who is responsible for quality of acute medical care?
Authors: B L Taylor, S N Pilkington, G B Smith, P J McQuillan
Journal: BMJ (1996)

EDITOR,—The attitudes of consultant physicians to the Calman proposals provide important information about the organisation of acute medical care in Britain.1 Recently, in response to such audits as the national confidential enquiry into perioperative deaths and the confidential enquiry into maternal deaths, many acute specialties have seen an increase in consultants' involvement in emergency care. General medical practice has escaped such scrutiny, and this together with the tendency to subspecialisation has apparently led to a system in which trainees provide most …
Abstract 4510: Pulmonary Hypertension before Transcatheter Aortic Valve Implantation Is Reversible and Lacks Prognostic Significance
Authors: Abdullah M Al Ali, Brad Munt, Lukas Altwegg, Karin Humphries, Ronald Carere, Anson Cheung, Samuel V Lichtenstein, Robert Moss, Sanjeevan Pasupati, Christopher R Thompson, Jian Ye, John Webb
Journal: Circulation (2008)

The prognostic significance of pulmonary hypertension (PH) and the potential for reversibility in the setting of aortic stenosis (AS) have been debated. We examined the clinical correlates and prognostic significance of PH in high risk elderly patients with symptomatic severe AS undergoing transcatheter aortic valve implantation (AVI). AVI was performed in 143 patients. Adequate echocardiographic estimation of baseline pulmonary artery systolic pressure was available in 115 (80%). Patients were divided into 3 groups according to baseline pulmonary artery pressure estimated by transthoracic echocardiogram: I: &lt;30 mmHg, II: 30 –50 mmHg and III: &gt;50 mmHg. Clinical and echocardiographic follow-up was obtained at 1, 6 and 12 months after AVI. Group I consisted of 17 patients (15%), group II 58 patients (50%) and group III 40 patients (35%). At baseline the three groups were similar in terms of age, functional status, presence of severe pulmonary disease, aortic valve area and mean gradient. Patients with severe PH (group III) were more likely to have left ventricular dysfunction (LVEF &lt;50%) than patients with mild to moderate PH (groups I and II) (52% vs. 21%, p=0.002) and had more severe mitral regurgitation (grade ≥ 3 in 68% vs. 41%, p =0.0002). At one month, systolic pulmonary artery pressure fell significantly in group III (11.0 ± 14.3 mmHg, p=0.0008) and this reduction was maintained at 6 months. However, the changes in group I (increase of 7.1 ± 8.7 mmHg, p=0.07) and group II (decrease of 0.9 ± 9.3 mmHg, p=0.53) were not significant. Mortality at one year following AVI was 21%, but was not related to severity of PH. Using group III as a reference, hazard ratios were 0.83 (95% CI: 0.24 –2.9) for group I and 0.88 (95% CI: 0.4 –1.9) for group II. In elderly patients with severe AS treated with transcatheter AVI, severe PH is associated with more depressed left ventricular function and more severe mitral regurgitation. Severe PH is associated with a significant and greater fall in pulmonary pressure following AVI and does not influence one year survival.
The Membrane Attack Complex of Complement
Authors: H J Muller-Eberhard
Journal: Annual Review of Immunology (1986)

Cell-killing mechanisms are essential components of host defense against infectious agents, parasites, and malignant cells. We distinguish humoral and cellular killing mechanisms. Complement utilizes specific proteins to assemble its killer molecule. Macrophages generate active oxygen radicals that injure target membranes. Lymphocytes, like complement, use protein molecules as tools in the cellular cytotoxicity reaction. As will be suggested at the conclusion of this chapter, considerable similarity between the structure of the cytolytic apparatus of complement and that of lymphocytes has recently come to light. An in-depth knowledge of the structure and function of the killer molecule of complement may therefore facilitate elucidation of the cell-killing mechanism of lymphocytes. Complement encompasses 20 proteins, not including the various cell­ surface complement receptors and regulatory proteins. Only 5 of these 20 proteins participate directly in cell killing-C5, C6, C7, C8, and C9-and none has enzymatic activity, proteolytic or lipolytic. Upon activation of C5, the 5 proteins interact in a sequential manner and fuse into a macromo­ lecular organization, called the membrarie attack complex or MAC. Fusion brings forth hydrophobic sites through which the complex inserts itself into the hydrocarbon core of lipid membranes. There it forms transmembrane channels, the largest of which constitutes tubular poly C9. Activation of C5 is accomplished by a highly specific serine protease, C5 convertase, itself an assembly of three protein molecules. Thus, formation of the MAC is initiated enzymatically, but this enzyme does not participate in actual membrane attack, which is entirely a physicochemical process.
Exploratory laparotomy and splenectomy for Hodgkin's disease: a commentary.
Authors: S A Rosenberg
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.4.574 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3357003 Exploratory laparotomy and splenectomy for Hodgkin's disease: a commentary. S A RosenbergxS A RosenbergSearch for articles by this author Show More Stanford University School of Medicine, CA. https://doi.org/10.1200/JCO.1988.6.4.574 PDF "Exploratory laparotomy and splenectomy for Hodgkin's disease: a commentary.." Journal of Clinical Oncology, 6(4), pp. 574–575© 1988 by American Society of Clinical Oncology
Prevalence of Body Mass Index Lower Than 16 Among Women in Low- and Middle-Income Countries
Authors: Fahad Razak, Daniel J. Corsi, Arthur S. Slutsky, Anura Kurpad, Lisa Berkman, Andreas Laupacis, S. V. Subramanian
Journal: JAMA (2015)

IMPORTANCE Body mass index (BMI) lower than 16 is the most severe category of adult undernutrition and is associated with substantial morbidity, increased mortality, and poor maternal-fetal outcomes such as low-birth-weight newborns.Little is known about the prevalence and distribution of BMI lower than 16 in low-and middle-income countries (LMIC).OBJECTIVE To determine the prevalence and distribution of BMI lower than 16 and its change in prevalence over time in women in LMIC.DESIGN, SETTINGS, AND PARTICIPANTS Cross-sectional data analysis composed of nationally representative surveys from 1993 through 2012 from the Demographic and Health Surveys Program.Women aged 20 through 49 years from 60 LMIC (N = 500 761) and a subset of 40 countries with repeated surveys (N = 604 144) were examined.EXPOSURES Wealth was measured using a validated asset index, age was categorized in deciles, education by highest completed level (none, primary, secondary, or greater), and place of residence as urban vs rural. MAIN OUTCOMES AND MEASURESThe primary outcome was BMI lower than 16.Analyses assessed the prevalence of BMI lower than 16, its association with sociodemographic factors, and change in prevalence.Logistic regression models were used to calculate odds ratios (ORs), adjusting for survey design and age structure.RESULTS Among countries examined, the pooled, weighted, and age-standardized prevalence of BMI lower than 16 was 1.8% (95% CI, 1.7% to 1.8%) with the highest prevalence in India (6.2% [95% CI, 5.9% to 6.5%]), followed by Bangladesh (3.9% [95% CI, 3.4% to 4.3%]), Madagascar (3.4% [95% CI, 2.8% to 4.0%], Timor-Leste (2.9% [95% CI, 2.4% to 3.2%]), Senegal (2.5% [95% CI, 1.9% to 3.2%]), and Sierra Leone (2.2% [95% CI, 1.3% to 3.0%]); and 6 countries had prevalences lower than 0.1% (Albania, Bolivia, Egypt, Peru, Swaziland, and Turkey).The prevalence of BMI lower than 16 in women with a secondary or higher education level was 0.51% (95% CI, 0.47% to 0.55%), and in mutually adjusted models, a less than primary education level was associated with an OR of 1.4 (95% CI, 1.2 to 1.6).The prevalence of BMI lower than 16 was 0.43% (95% CI, 0.37% to 0.48%) in the highest wealth quintile with an OR of 3.0 (95% CI, 2.4 to 3.7) in the lowest wealth quintile.Among the 24 of 39 countries with repeated surveys, there was no decrease in prevalence.In Bangladesh and India, rates were declining with an average absolute change annually of -0.52% (95% CI, -0.58% to -0.46%) in Bangladesh and -0.11% (95% CI, -0.12% to -0.10%) in India.CONCLUSIONS AND RELEVANCE Among women in 60 LMIC, the prevalence of BMI lower than 16 was 1.8%, and was associated with poverty and low education levels.Prevalence of BMI lower than 16 did not decrease over time in most countries studied.
Cellular Folate Binding Proteins; Function and Significance
Authors: C. Wagner
Journal: Annual Review of Nutrition (1982)

It appears that specific functions may be assigned to some of the cellular folate binding proteins with some degree of certainty. Those that are membrane bound or derived from membranes probably have a role in transport of folate molecules into the cell. This is in spite of the fact that the localization of this protein to the plasma membrane has been carried out in only a limited number of cases. The role of the folate binding protein of L. casei in transport is much clearer. Bacteria provide the opportunity to obtain mutants defective in both transport and binding, and such mutants are more difficult to obtain with mammalian cell lines. The intracellular folate binding proteins have been discovered so far only in liver. The fact that the folate binding proteins in rat liver mitochondria are two enzymes, dimethylglycine dehydrogenase and sarcosine dehydrogenase, suggests that enzyme activities may eventually be discovered for the other intracellular folate binding proteins. This may not possible, however, and a reasonably strong case has been made that the folate binding protein of cytosol, FBP-CII, serves in a storage role. Such a storage role is difficult to prove since it depends, in part, on the demonstration that the protein becomes progressively less saturated during deficiency--a situation true also for enzymes.
Peripheral T-cell lymphoma after anti-CD20 antibody therapy.
Authors: S Tetreault, S L Abler, B Robbins, A Saven
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.4.1635 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9552080 Peripheral T-cell lymphoma after anti-CD20 antibody therapy. S TetreaultxS TetreaultSearch for articles by this author , S L AblerxS L AblerSearch for articles by this author , B RobbinsxB RobbinsSearch for articles by this author , A SavenxA SavenSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.4.1635 First Page PDF © 1998 by American Society of Clinical Oncology