tbuckley/cabot-search huggingface dataset:
Hand cortical bone mass and its associations with radiographic joint damage and fractures in 50-70 year old female patients with rheumatoid arthritis: cross sectional Oslo-Truro-Amsterdam (OSTRA) collaborative study
Authors: G Haugeberg
Journal: Annals of the Rheumatic Diseases (2004)

To investigate the relationship between hand bone mineral density (BMD) and radiographic joint damage, and between hand BMD and fractures in 50-70 year old women with longstanding RA.Demographic, clinical data, and imaging data on hand radiographs and Genants vertebral deformity score on spine radiographs were collected from 135 women with RA of > or =5 years, recruited from three European rheumatology clinics. Metacarpal hand BMD was measured by digital hand x ray radiogrammetry (DXR), and hip and lumbar spine BMD by dual x ray absorptiometry (DXA). Multiple regression analyses were used to examine associations between hand BMD and radiographic joint damage, and hand BMD and fractures.Hand BMD was strongly and independently associated with radiographic hand joint damage in a linear regression model adjusted for age, centre, BMI, disease duration, RF, 18 deformed joint count, ESR, and femoral neck BMD. In a multivariate logistic regression model adjusted for relevant variables, hand BMD and femoral neck BMD, but not spine BMD, were independently associated with vertebral deformities and with non-vertebral fractures.BMD measured by DXR on conventional hand radiographs in patients with RA may potentially be used as an indicator of joint damage and of vertebral and non-vertebral fracture risk.
Hepatitis B Infection
Authors: Wolf Szmuness
Journal: JAMA (1974)

Five hundred eighty-three patients and 451 medical personnel of 15 hemodialysis centers were surveyed for hepatitis B infections. Hepatitis B antigen (HB Ag) was detected in 16.8% of the patients and in 2.4% of the medical staff; specific antibody to HB Ag (HB Ab) was detected in 34.0% and 31.3%, respectively. The cumulative prevalence of HB Ag and HB Ab varied widely among the centers. The prevalence of HB Ag or HB Ab in patients was related to duration of dialysis treatment, but not to blood transfusions. Significant differences in prevalence of serologic indicators of hepatitis B infection among various staff categories were not observed. Sixty-one percent of family contacts of dialysis patients with a history of hepatitis B infection were found to have HB Ag or HB Ab.
How to Respond to an Implantable Cardioverter-Defibrillator Shock
Authors: Samuel F. Sears, Julie B. Shea, Jamie B. Conti
Journal: Circulation (2005)

Received ICD shock Feel fine immediately Call heart doctor to discuss the event and arrange appropriate follow-up Received ICD shock Experiencing chest pain/pressure, shortness of breath, rapid heart action.Feel dizzy, confused, or not well Seek medical attention immediately
Impact of Extended-Duration Shifts on Medical Errors, Adverse Events, and Attentional Failures
Authors: Laura K Barger, Najib T Ayas, Brian E Cade, John W Cronin, Bernard Rosner, Frank E Speizer, Charles A Czeisler
Journal: PLoS Medicine (2006)

Background A recent randomized controlled trial in critical-care units revealed that the elimination of extended-duration work shifts (≥24 h) reduces the rates of significant medical errors and polysomnographically recorded attentional failures. This raised the concern that the extended-duration shifts commonly worked by interns may contribute to the risk of medical errors being made, and perhaps to the risk of adverse events more generally. Our current study assessed whether extended-duration shifts worked by interns are associated with significant medical errors, adverse events, and attentional failures in a diverse population of interns across the United States. Methods and Findings We conducted a Web-based survey, across the United States, in which 2,737 residents in their first postgraduate year (interns) completed 17,003 monthly reports. The association between the number of extended-duration shifts worked in the month and the reporting of significant medical errors, preventable adverse events, and attentional failures was assessed using a case-crossover analysis in which each intern acted as his/her own control. Compared to months in which no extended-duration shifts were worked, during months in which between one and four extended-duration shifts and five or more extended-duration shifts were worked, the odds ratios of reporting at least one fatigue-related significant medical error were 3.5 (95% confidence interval [CI], 3.3–3.7) and 7.5 (95% CI, 7.2–7.8), respectively. The respective odds ratios for fatigue-related preventable adverse events, 8.7 (95% CI, 3.4–22) and 7.0 (95% CI, 4.3–11), were also increased. Interns working five or more extended-duration shifts per month reported more attentional failures during lectures, rounds, and clinical activities, including surgery and reported 300% more fatigue-related preventable adverse events resulting in a fatality. Conclusions In our survey, extended-duration work shifts were associated with an increased risk of significant medical errors, adverse events, and attentional failures in interns across the United States. These results have important public policy implications for postgraduate medical education.
PROFILE OF JUDO INJURIES: THE PHILIPPINE EXPERIENCE
Authors: Reylin San Juan
Journal: British Journal of Sports Medicine (2014)

Background Epidemiological studies on judo injuries in Western countries have been carried out before. Scant information is available on judo competition injuries in the Philippines. Objective To assess injury rates in Filipino young and adult judo athletes. Design Prospective. Setting Data were collected at the 2012 Philippine National Games in Dumaguete City, Philippines using a standardized questionnaire. Participants Subjects were senior men (n=102) and Senior Women (n=40) as well as junior men (n=42) and Junior Women (n=25). The tournament was open to all eligible judo athletes in the country, including members from the National Team. Junior category was 19 years old and below, while the senior division was open. Risk factor assessment Competition injuries were assessed by the tournament physician. Main outcome measurements Injury rate per athlete-exposures (A-E). Results The injury rate for the men was 140.63/1,000 A-E (95% CI: 75.66–205.60) and for the women, 52.24/1,000 A-E (95% CI: 13.54.90.94). For the boys, the rate was 177.08 (95% CI: 92.90–261.26) and for the girls, 31.25 (95% CI: 12.06–74.56). The upper limbs were most susceptible to injury in both men and women with injury rates of 70.31/1,000 A-E (95% CI: 24.37–116.25) and 37.31/1,000 A-E (95% CI: 4.60–70.02), respectively. Conclusions There was no difference in injury rate between the men and the boys. There also was no difference in injury rate between women and girls.
Integrins in Vascular Development
Authors: Paul A. Rupp, Charles D. Little
Journal: Circulation Research (2001)

In recent years, there has been a sustained interest in vascularization processes. Much, if not all, of the work has included the concept of new vessel morphogenesis. Surprisingly, most of the work has not addressed developmental mechanisms directly, but rather as an offshoot of a disease process, wound healing process, or from the perspective of inducing vessels in an ischemic site. One theme has dominated the various studies on capillary or endothelial tube morphogenesis—integrin-mediated cell behavior. Integrin biology impacts virtually every known step of nascent vessel formation. In this review article, we attempted to summarize key findings from the viewpoint of developmental biologists/morphologists. We also attempted to summarize and contrast data obtained using integrin gene ablation approaches in mice with other experimental systems. It is hoped this review will provide a distinct cell biological perspective to vascular scientists from the clinical, molecular, and tissue engineering communities.
Prospective evaluation of corrected QT intervals and arrhythmias after exposure to epirubicin, cyclophosphamide, and 5-fluorouracil in women with breast cancer
Authors: K. Kitagawa, K. Kawada, S. Morita, M. Inada, A. Mitsuma, M. Sawaki, S. Iino, Y. Inden, T. Murohara, T. Imai, Y. Ando
Journal: Annals of Oncology (2011)
Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy
Authors: Tuure Kinnunen, Kalle Jutila, William W. Kwok, Marja Rytkönen-Nissinen, Anu Immonen, Soili Saarelainen, Ale Närvänen, Antti Taivainen, Tuomas Virtanen
Journal: Journal of Allergy and Clinical Immunology (2007)
Successful stenting of a pulmonary arterial stenosis after a single lung transplant.
Authors: G Ferretti, M Boutelant, F Thony, F Carpentier, C Pison, M Guignier
Journal: Thorax (1995)

A 44 year old patient with end stage idiopathic pulmonary fibrosis underwent single left lung transplantation. A perfusion lung scan performed 13 days after transplantation revealed deficient perfusion in the transplanted lung. Pulmonary angiography showed severe pulmonary artery anastomotic stenosis. Percutaneous insertion of a balloon expandable stent improved both pulmonary perfusion and respiratory function.
Regulation of GABAA receptor function by protein kinase C phosphorylation
Authors: Belinda J. Krishek, Xinmin Xie, Craig Blackstone, Richard L. Huganir, Stephen J. Moss, Trevor G. Smart
Journal: Neuron (1994)

GABAA receptors possess consensus sequences for phosphorylation by PKC that are located on the presumed intracellular domains of β and γ2 subunits. PKC phosphorylation sites were analyzed using purified receptor subunits and were located on up to 3 serine residues in β1 and γ2 subunits. The role of phosphorylation in receptor function was studied using recombinant receptors expressed in kidney cells and Xenopus oocytes and was compared with native neuronal GABAA receptors. For recombinant and native GABAA receptors, PKC phosphorylation caused a reduction in the amplitudes of GABA-activated currents without affecting the time constants for current decay. Selective site-directed mutagenesis of the serine residues reduced the effects of phorbol esters and revealed that serine 343 in the γ2 subunit exerted the largest effect on the GABA-activated response. These results indicate that PKC phosphorylation can differentially modulate GABAA receptor function.
Transcriptional profiling of IKK2/NF-κB— and p38 MAP kinasedependent gene expression in TNF-α—stimulated primary human endothelial cells
Authors: Dorothee Viemann, Matthias Goebeler, Sybille Schmid, Kerstin Klimmek, Clemens Sorg, Stephan Ludwig, Johannes Roth
Journal: Blood (2004)
First-line treatment for chronic myeloid leukemia: dasatinib, nilotinib, or imatinib
Authors: Guoqing Wei, Shamudheen Rafiyath, Delong Liu
Journal: Journal of Hematology & Oncology (2010)

Abstract Imatinib, a tyrosine kinase inhibitor (TKI) of BCR-ABL, was the standard first-line therapy for chronic myeloid leukemia (CML) for almost 10 years. Dasatinib and nilotinib, two newer drugs with higher potency than imatinib against BCR-ABL and activity against most imatinib-resistant BCR-ABL mutations, have each shown superior efficacy compared with imatinib for first-line treatment of chronic-phase CML in randomized phase 3 trials. With 14 months follow-up time, available data suggest no obvious differences in efficacy between dasatinib and nilotinib. Compared with imatinib, dasatinib is associated with higher rates of pleural effusion and thrombocytopenia, but lower rates of edema, gastrointestinal AEs, musculoskeletal AEs, and rash. Nilotinib is associated with higher rates of dermatologic toxicity, headache, and biochemical abnormalities associated with hepatic and pancreatic toxicity compared with imatinib, but lower rates of edema, gastrointestinal AEs, muscle spasm, and neutropenia. Several studies have shown that poor adherence to imatinib detrimentally affects responses and should be considered in patients with a suboptimal response. The different dosing requirements of dasatinib (once daily with or without food) and nilotinib (twice daily with fasting) may be an additional factor in selecting frontline agents. This review compares and contrasts the three FDA approved first line TKI agents.
Exercise capacity in chronic respiratory diseases
Authors: G. Fiorenzano, C. Santoriello, V. Musella, M. Polverino
Journal: European Respiratory Journal (2010)

To the Editors: 

We read with great interest the paper by Swallow et al. 1, comparing skeletal muscle function in chronic obstructive pulmonary disease (COPD) patients and patients with idiopathic scoliosis. In our opinion, the reported muscular weakness in patients with a chronic noninflammatory respiratory disease may have important implications in rehabilitation and prevention of chronic respiratory diseases.

Pulmonary rehabilitation is defined as an “evidence-based, multidisciplinary, comprehensive intervention for patients with chronic respiratory diseases…” 2, but most of the scientific literature is …
Hypertrophic Cardiomyopathy Is Predominantly a Disease of Left Ventricular Outflow Tract Obstruction
Authors: Martin S. Maron, Iacopo Olivotto, Andrey G. Zenovich, Mark S. Link, Natesa G. Pandian, Jeffery T. Kuvin, Stefano Nistri, Franco Cecchi, James E. Udelson, Barry J. Maron
Journal: Circulation (2006)

Nonobstructive hypertrophic cardiomyopathy (HCM) has been regarded as the predominant hemodynamic form of the disease on the basis of assessment of outflow gradient under resting conditions. We sought to prospectively define the prevalence, clinical profile, and significance of left ventricular (LV) outflow tract obstruction under resting conditions and with physiological exercise in a large HCM cohort.We prospectively analyzed 320 consecutive HCM patients (age, 47+/-17 years), measuring LV outflow gradient at rest, with Valsalva maneuver, and with exercise echocardiography. LV outflow obstruction was present at rest and/or with exercise in 225 patients (70%); 119 had rest gradients > or = 50 mm Hg and were not exercised. Of the other 201 patients with gradients < 50 mm Hg at rest (average, 4+/-9 mm Hg), 106 developed mechanical obstruction to LV outflow resulting from mitral valve-septal contact after exercise (80+/-43 mm Hg), including 76 with marked gradients > or = 50 mm Hg and 46 with heart failure symptoms. The remaining 95 patients (30%) had no or small gradients (< 30 mm Hg) both at rest and with exercise. Valsalva maneuver underestimated the presence and magnitude of exercise-induced obstruction.Among those patients who come to clinical evaluation, HCM is a predominantly obstructive disease in which LV outflow gradients, frequently associated with heart failure symptoms and often identified only with exercise, are evident in most patients (ie, 70%). Identification of LV outflow obstruction with exercise echocardiography may broaden management options in HCM by identifying symptomatic patients not otherwise regarded as potential candidates for septal reduction therapy. Assessment of subaortic gradients with exercise should be a routine component of the evaluation of HCM patients without outflow obstruction under resting conditions.
Serum VEGF levels as predictive marker of bisphosphonate-related osteonecrosis of the jaw
Authors: Bruno Vincenzi, Andrea Napolitano, Alice Zoccoli, Michele Iuliani, Francesco Pantano, Nicola Papapietro, Vincenzo Denaro, Daniele Santini, Giuseppe Tonini
Journal: Journal of Hematology & Oncology (2012)

Recent studies have been reported that angiogenesis suppression may play a role in developing bisphosphonate-related osteonecrosis of the jaw (B-ONJ). According to these evidence we evaluated the role of VEGF as predictive marker of B-ONJ onset. Of the 81 patients, 6 developed B-ONJ following bisphosphonate treatment. These patients showed a strongest decrease in VEGF circulating levels at day 7 and at day 21 after the first administration. These data demonstrated for the first time that the anti-angiogenic properties of bisphosphonates are directly linked to B-ONJ pathogenesis and serum VEGF levels could represent an effective early predictive marker.
The Effects of Chronic Alcohol Abuse on Pulmonary Glutathione Homeostasis
Authors: MARC MOSS, DAVID M. GUIDOT, MONIQUE WONG-LAMBERTINA, TERRI TEN HOOR, RAFAEL L. PEREZ, LOU ANN S. BROWN
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The incidence and severity of the acute respiratory distress syndrome (ARDS) is increased in critically ill patients with a prior history of chronic alcohol abuse; however, the specific mechanisms responsible for this association are unknown. Recently, we determined that chronic ethanol ingestion in rats decreased the alveolar epithelial lining fluid (ELF) concentration of the antioxidant glutathione (GSH), which is a characteristic finding in patients with ARDS. However, the effects of chronic alcohol abuse on the human alveolar epithelium are essentially unknown. Therefore, as a first step we asked if chronic alcohol abuse, independent of other comorbid conditions, decreases the concentration of GSH in the human lung. We determined that otherwise healthy chronic alcoholics had significantly decreased ELF concentrations of GSH compared with nonalcoholic control subjects (79 μ mol [48 to 118 μ mol] versus 576 μ mol [493 to 728 mmol], p < 0.001). Furthermore, the percentage of GSH in the oxidized form was higher in the chronic alcoholics (9.8% [2.2 to 14.8%] versus 2.8% [0.4 to 4.0%] p = 0.05), indicative of increased utilization of GSH. This is the first report that chronic alcohol abuse alters GSH homeostasis in the human lung, and suggests a potential mechanism by which chronic alcohol abuse predisposes susceptible patients to develop ARDS. Moss M, Guidot DM, Wong-Lambertina M, Ten Hoor T, Perez RL, Brown LAS. The effects of chronic alcohol abuse on pulmonary glutathione homeostasis.
Abstract 1203: Therapeutic opportunities for anti-Met antibody (MetMAb) in breast cancer
Authors: Merchant Mark, Zhong Zheng, Jing Peng, Jun Li, Elaine Mai, Judy Young, Dela Cruz Darlene, Jinfeng Liu, Robert Yauch, Jiping Zha, Ellen Filvaroff
Journal: Cancer Research (2011)

Abstract The hepatocyte growth factor (HGF)/Met pathway drives cell proliferation, survival, migration and invasion, which are hallmarks of cancer. Animal models and microarray data suggest that elevated expression of Met is a poor prognostic factor in breast tumors. Our evaluation of primary breast tumors and cell lines has confirmed that expression of Met is found predominantly in the basal sub-type, which includes estrogen receptor (ER), progesterone receptor (PR) and HER2 triple negative (3N) tumors as well as some HER2+ basal tumors. In a panel of 3N basal breast tumors, 96% (25/26) of samples express Met by enzyme-linked immunosorbant assay (ELISA), with 42% (11/26) positive by immuno-histochemistry (IHC). All of the samples were positive for HGF as determined by ECLA, with 32% (8/25) of these primary tumors showing robust staining by IHC. To further explore the biological response of basal breast cancers to HGF, a panel of basal breast cancer cell lines were evaluated in cell proliferation, migration and invasion assays. While most lines tested showed a modest response to HGF in proliferation assays, the migratory and invasive response to HGF was more robust. Assessment of signaling pathways and gene signatures was also performed to better understand the nature of Met signaling leading to biological outcomes. HGF responsive lines were evaluated for growth in transgenic SCID mice expressing human HGF. MetMAb, a potent HGF-blocking Met monovalent monoclonal antibody, acts to inhibit HGF-driven effects in basal breast cancer cell lines in vitro and xenograft growth in vivo. Taken together, these data suggest that Met can drive invasive growth of basal breast tumors, and that treatment with MetMAb, alone or in combination with standard of care, may be therapeutically beneficial in these tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1203. doi:10.1158/1538-7445.AM2011-1203
MicroRNA-17~92 Is Required for Nephrogenesis and Renal Function
Authors: April K. Marrone, Donna B. Stolz, Sheldon I. Bastacky, Dennis Kostka, Andrew J. Bodnar, Jacqueline Ho
Journal: Journal of the American Society of Nephrology (2014)

Deletion of all microRNAs (miRNAs) in nephron progenitors leads to premature loss of these cells, but the roles of specific miRNAs in progenitors have not been identified. Deletions in the MIR17HG cluster (miR-17~92 in mice), detected in a subset of patients with Feingold syndrome, represent the first miRNA mutations to be associated with a developmental defect in humans. Although MIR17HG is expressed in the developing kidney, and patients with Feingold syndrome caused by MYCN mutations have renal anomalies, it remains unclear to what extent MIR17HG contributes to renal development and function. To define the role of miR-17~92, we generated mice with a conditional deletion of miR-17~92 in nephron progenitors and their derivatives. The nephron progenitor population was preserved in these mice; however, this deletion impaired progenitor cell proliferation and reduced the number of developing nephrons. Postnatally, mutant mice developed signs of renal disease, including albuminuria by 6 weeks and focal podocyte foot process effacement and glomerulosclerosis at 3 months. Taken together, these data support a role for this miRNA cluster in renal development, specifically in the regulation of nephron development, with subsequent consequences for renal function in adult mice.
Changes in the Hemostatic Mechanism After Myocardial Infarction
Authors: PAUL B. GOLDENFARB, MARY H. CATHEY, STANLEY ZUCKER, PATRICIA WILBER, JAMES J. CORRIGAN
Journal: Circulation (1971)

Plasma coagulation factors, adenosine diphosphate-induced platelet aggregation, and fibrinolytic activity were studied in male survivors of myocardial infarction and in healthy normal men. Infarction survivors had significant elevations of factors VIII and X and of adenosine diphosphate-induced platelet aggregation. The fibrinolytic system was altered toward reduced plasminogen activation, increased antiurokinase activity, and elevated antiplasmin activity. These findings suggest that some men with prior myocardial infarction have a heightened tendency to thrombogenesis. This tendency may represent a response to previous cardiac insult or may contribute to its pathogenesis.
Quantitative Immunoelectrophoretic Analysis of Extract from Cow Hair and Dander
Authors: P Prahl, B. Weeke, H. Løwenstein
Journal: Allergy (1978)

Quantitative immunoelectrophoresis used for the analysis of a diabased, centrifuged and freeze‐dried extract from cow hair and dander revealed 17 antigens. Five of these were identified as serum proteins. Partial identity to antigens of serum and extract from hair and dander of goat, sheep, swine, horse, dog, cat and guinea pig, and to antigens of house dust was demonstrated. Sera from 36 patients with manifest allergy to cow hair and dander selected on the basis of case history, RAST, skin and provocation test, were examined in crossed radioimmunoelectrophoresis (CRIE); sera from five persons with high serum IgE, but without allergy to cow hair and dander, and sera from five normal individuals were controls 31/36 of the sera contained IgE with specific affinity for two of the antigens of the extract. Further, two major and six minor allergens were identified. The control sera showed no specific IgE binding. A significant positive correlation was found between RAST and CRIE for the first group of patients. The approximate molecular weights of the four major allergens obtained by means of gel chromarography were: 2.4 × 10 4 , 2 × 10 4 , 2 × 10 3 dalton, respectively. Using Con‐A and Con‐A Sepharose in crossed immunoaffinoelectrophoresis, eight of the antigens were revealed to contain groups with affinity for Con‐A.