Captopril and Enalapril
Authors: IRENE GAVRAS
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 April 1983Captopril and EnalaprilIRENE GAVRAS, M.D., HARALAMBOS GAVRAS, M.D.IRENE GAVRAS, M.D., HARALAMBOS GAVRAS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-4-556_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Inhibition of the angiotensin-converting enzyme by captopril is an established treatment for hypertension (1) and is increasingly popular as an adjunct treatment for congestive cardiac failure (2). Yet the possibility of an unpredictable and potentially adverse reaction effectively deters the more widespread use of angiotension-converting enzyme inhibition.Most investigators believe that the side effects of captopril are due to the mercapto group in its molecule identical to other heavy metal antagonists (such as penicillamine) with similar molecular structure but different pharmacologic actions. However, the inhibition of the angiotensin-converting enzyme could account for adverse reactions.Enalapril maleate (MK-421;...References1. GAVRASBRUNNERGAVRAS HHI. Captopril in the treatment of hypertension. Ann Intern Med. 1981;95:505-6. LinkGoogle Scholar2. GAVRAS H. Congestive heart failure: treatment by angiotension blockade. Primary Cardiol. 1980;6:103-13. Google Scholar3. PATCHETTHARRISTRISTRAM AEE. A new class of angiotension-converting enzyme inhibitors. Nature. 1980;288:280-3. CrossrefMedlineGoogle Scholar4. GAVRASWAEBERGAVRASBIOLLAZBRUNNERDAVIES HBIJHR. Antihypertensive effect of the new oral angiotensin converting enzyme inhibitor "MK-421". Lancet. 1981;1:543-6. CrossrefGoogle Scholar5. FERGUSONVLASSESIRVINSWANSONLEE RPJBR. A comparative pilot study of enalapril, a new converting enzyme inhibitor, and hydrochlorothiazide in essential hypertension. J Clin Pharmacol. 1982;22:281-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston University Medical Center Boston, MA 02118 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAngiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers induced pemphigus: A case series and literature reviewDrug ReactionsDoes Blockade of Angiotensin II Receptors Offer Clinical Benefits over Inhibition of Angiotensin-Converting Enzyme?Grand Rounds from International Lupus Centres A young woman with SLE: diagnostic and therapeutic challengesEnalapril-induced lichen planus-like eruptionCough and Angioneurotic Edema Associated with Angiotensin-Converting Enzyme Inhibitor Therapy A Review of the Literature and PathophysiologyZafar H. Israili, PhD, W. Dallas Hall, MDDrug-induced pemphigus related to angiotensin-converting enzyme inhibitorsCutaneous reaction to captopril: value of patch testsEnalapril induced angioedemaSafety issues during antihypertensive treatment with angiotensin converting enzyme inhibitorsSafety issues during antihypertensive treatment with angiotensin converting enzyme inhibitorsAngiotensin converting enzyme inhibitors. Properties and side effects.LACK OF CROSS SENSITIVITY BETWEEN CAPTOPRIL AND ENALAPRILClinical utility of angiotensin converting enzyme inhibitors in hypertensionAdverse Reactions with Angiotensin Converting Enzyme (ACE) InhibitorsEnalapril: A New Angiotensin Converting Enzyme InhibitorIntra-individual comparison of captopril and enalapril in patients undergoing regular haemodialysisAluminium phosphide ingestion.Severe cutaneous reactions to captopril.Renin InhibitorsPilot Study of the Effects of the Angiotensin-Converting Enzyme Inhibitor CI-906 on Patients with Essential HypertensionHypertensive crisis in systemic sclerosis: treatment with the new oral angiotensin converting enzyme inhibitor mk 421 (enalapril) in captopril-intolerant patientsEnalapril Treatment in a Patient With Impaired Renal Function and Intolerance to CaptoprilEnalapril, A Rash, and CaptoprilSPENCER H. KUBO, M.D., ROBERT J. CODY, M.D.Captopril and EnalaprilJONATHAN K. WILKIN, M.D. 1 April 1983Volume 98, Issue 4Page: 556-557KeywordsAdverse reactionsAngiotensin converting enzymeEnzymesHeart failureHeavy metalsHypertension Issue Published: 1 April 1983 PDF downloadLoading ...