tbuckley/cabot-search huggingface dataset:
A Single Dose of Thrombopoietin Shortly After Myelosuppressive Total Body Irradiation Prevents Pancytopenia in Mice by Promoting Short-Term Multilineage Spleen-Repopulating Cells at the Transient Expense of Bone Marrow–Repopulating Cells
Authors: Karen J. Neelis, Trudi P. Visser, Wati Dimjati, G. Roger Thomas, Paul J. Fielder, Duane Bloedow, Dan L. Eaton, Gerard Wagemaker
Journal: Blood (1998)
Evaluation of Cyclosporine-Treated Mice as Hosts for Growing and Testing the Chemosensitivity of First-Transplant-Generation Human Tumor Xenografts Implanted Under the Kidney Capsule2
Authors: James A. Bennett, Vernon A. Pilon, Deborah R. Briggs, Martin F. McKneally
Journal: JNCI Journal of the National Cancer Institute (1985)

Freshly resected human tumors were grown as xenografts under the kidney capsules of conventional mice immunosuppressed by daily treatment with cyclosporine A (CsA; 60 mg/kg/day, sc). Tumor persistence and growth in CsA-treated mice were comparable to those found in nude mice. Lower doses or less aggressive schedules of CsA resulted in xenograft rejection. CsA (60 mg/kg/day, sc) treatment of mice was toxic but not lethal. It resulted in a 20% decrease in water consumption, a 10% loss in body weight, and significant reductions in thymus, kidney, and liver weights. Therapeutic doses of cancer chemotherapeutic agents were tolerated by CsA-treated mice, but 10% lethal doses were lethal in 100% of the mice. These results indicate that CsA-treated mice would be an economic alternative to nude mice for growing human tumor xenografts and for testing their chemosensitivity, with the caveat that the dose-limiting toxicity of cancer chemotherapeutic agents will be reached at lower doses in CsA-treated mice.
Serum creatine phosphokinase in schizophrenia
Authors: H Y Meltzer
Journal: American Journal of Psychiatry (1976)

The author notes that increased serum creatine phosphokinase (CPK) activity is found in the majority of hospitalized acutely disturbed schizophrenics and patients with affective psychoses. It is probable that some of these increases do not result from nonspecific factors such as activity, trauma, or stress, which do cause increases in some cases. Those patients who show increased CPK activity have more florid psychopathology and tend to have higher CPK levels in nonacute periods than those without increases. First-degree relatives of psychotic patients with elevated serum CPK have high-normal or slightly increased serum CPK. There is also evidence of other neuromuscular dysfunction in psychotic patients. The author concludes that the investigation of CPK may have considerable heuristic value for the study of schizophrenia and other psychoses.
Rare Variants in the Complement Factor H–Related Protein 5 Gene Contribute to Genetic Susceptibility to IgA Nephropathy
Authors: Ya-Ling Zhai, Si-Jun Meng, Li Zhu, Su-Fang Shi, Su-Xia Wang, Li-Jun Liu, Ji-Cheng Lv, Feng Yu, Ming-Hui Zhao, Hong Zhang
Journal: Journal of the American Society of Nephrology (2016)

A recent genome–wide association study of IgA nephropathy (IgAN) identified 1q32, which contains multiple complement regulatory genes, including the complement factor H ( CFH ) gene and the complement factor H–related ( CFHR s) genes, as an IgAN susceptibility locus. Abnormal complement activation caused by a mutation in CFHR5 was shown to cause CFHR5 nephropathy, which shares many characteristics with IgAN. To explore the genetic effect of variants in CFHR5 on IgAN susceptibility, we recruited 500 patients with IgAN and 576 healthy controls for genetic analysis. We sequenced all exons and their intronic flanking regions as well as the untranslated regions of CFHR5 and compared the frequencies of identified variants using the sequence kernel association test. We identified 32 variants in CFHR5 , including 28 rare and four common variants. The distribution of rare variants in CFHR5 in patients with IgAN differed significantly from that in controls ( P =0.002). Among the rare variants, in silico programs predicted nine as potential functional variants, which we then assessed in functional assays. Compared with wild-type CFHR5, three recombinant CFHR5 proteins, CFHR5-M (c.508G&gt;A/p.Val170Met), CFHR5-S (c.533A&gt;G/p.Asn178Ser), and CFHR5-D (c.822A&gt;T/p.Glu274Asp), showed significantly higher C3b binding capacity (CFHR5-M: 109.67%±3.54%; P =0.02; CFHR5-S: 174.27%±9.78%; P &lt;0.001; CFHR5-D: 127.25%±1.75%; P &lt;0.001), whereas another recombinant CFHR5 (c.776T&gt;A/p.Leu259Termination) showed less C3b binding (56.89%±0.57%; P &lt;0.001). Our study found that rare variants in CFHR5 may contribute to the genetic susceptibility to IgAN, which suggests that CFHR5 is an IgAN susceptibility gene.
Safe and rapid outpatient administration of cisplatin ≥ 75 mg/m<sup>2</sup> for lung cancer
Authors: A. Lavolã, S. Danel, V. Gounant, C. Epaud, L. Rosencher, M. Wislez, J. Cadranel, B. Milleron
Journal: Journal of Clinical Oncology (2008)

20737 Background: Cisplatin is a standard component of combination chemotherapy for non-small or small-cell lung cancer (NSCLC or SCLC), but presents toxic effects, in particular, renal. In most cases, 24-h hydratation is recommended to reduce nephrotoxicity after cisplatin administration, but requires hospitalization. Thus, quality of life of patients with short life expectancy is worsened and cost is higher. At our hospital for the past 25 years, intermediate to high doses of cisplatin with short hydratation are routinely administered and well-tolerated. The aim of our retrospective study was to confirm the safety of this practice in an outpatient clinic. Methods: 357 consecutive patients (median 58 years, range 25–81) with NSCLC or SCLC treated with cisplatin at a dose ≥ 75 mg/m2 (median cycles number: 3 (range 1–6) at an outpatient clinic between 2001 and 2007 were reviewed. Two L of G 5% with 4 g/L NaCl, 2 g/l KCl, 1 g/L MgCl2 and 1 g/L CaCl2 were administered and cisplatin was infused in 250 ml of saline solution at 1 mg/min. Neither mannitol nor diuretics were administered. Patients returned home after 6 h. Nephrotoxicity was defined as ≥ grade 1 according to NCIC Common Toxicity Criteria. Predictive factors in nephrotoxicity were analyzed. Results: Only 21 patients (6%) had nephrotoxicity, grade 1 (n=20) and grade 3 (n=1). Twelve of these 21 patients returned to grade 0 after completion of total cisplatin administration. Mean ΔCC (initial creatinine clearance-minimal creatinine clearance) was 11.4 mL/mn (range -65 to 95). Predictive factors independently associated with nephrotoxicity were comorbidity-associated (hypertension, diabetes, heart disease) (OR=4.97 CI 95% [1.8–13.7] p=0.002), initial SC ≥100 μmol/L (OR=8.3 CI 95% [2.55–27.4] p=0.0005) and dose at the first cycle cisplatin ≥ 100 mg/m2 (OR=10.8 CI 95% [3.6–32.5] p<0.0001). Conclusions: Rapid outpatient administration of cisplatin ≥75 mg/m2 is feasible without high risk of nephrotoxicity. No significant financial relationships to disclose.
Complete closure of a large gastric perforation caused by percutaneous endoscopic gastrostomy using over-the-scope clips
Authors: Hirohito Mori, Hideki Kobara, Shintaro Fujihara, Noriko Nishiyama, Taiga Chiyo, Tsutomu Masaki
Journal: Endoscopy (2016)

Complications of percutaneous endoscopic gastrostomy (PEG) include bleeding, infection, miss-puncture of other organs, and perforation [1] [2]. Herein we report on a large gastric perforation resulting from a PEG tube insertion that was successfully treated with a double over-the-scope clip technique.
PET in Cervical Cancer — Implications for `Staging,' Treatment Planning, Assessment of Prognosis, and Prediction of Response
Authors: Michael A. Gold
Journal: Journal of the National Comprehensive Cancer Network (2008)

The use of functional imaging techniques such as fluorodeoxyglucose-positron emission tomography and positron emission tomography–computed tomography to manage patients with cervical cancer is constantly increasing. Current roles include pretreatment staging and diagnosis of recurrent disease. Reports have also shown its ability to predict survival based on pre- and posttherapy scans. These techniques are not fool-proof, however, and reports of both false-negative and false-positive scans document some limitations. Future studies must further elucidate their exact roles in the management of this disease process.
High-Definition Single Cell Analysis (Hd-Sca) of Prostate Cancer (Pca) Cells in Matched Bone Marrow and Blood from Patients
Authors: A.J. Zurita, A. Carlsson, M.S. Luttgen, K. Bethel, C.J. Logothetis, J. Hicks, P. Kuhn
Journal: Annals of Oncology (2014)
Abstract 11369: Galectin-3, a Biomarker of Poor Prognosis in Heart Failure Remains Unchanged After Heart Transplantation
Authors: Jose N Nativi, Walter K Kremers, Tal Hasin, Omar Abou Ezzeddine, Sudhir S Kushwaha, Brooks S Edwards, Naveen L Pereira
Journal: Circulation (2012)

Introduction: Galectin (Gal) -3 is a novel biomarker of poor prognosis in patients with heart failure. Elevated Gal-3 levels are associated with advanced heart failure and cardiac fibrosis. The eff...
Supratentorial clear cell ependymomas with branching capillaries demonstrate characteristic clinicopathological features and pathological activation of nuclear factor-kappaB signaling
Authors: Dominique Figarella-Branger, Emmanuèle Lechapt-Zalcman, Emeline Tabouret, Stephanie Jünger, André Maues de Paula, Corinne Bouvier, Carole Colin, Anne Jouvet, Fabien Forest, Felipe Andreiuolo, Isabelle Quintin-Roue, Marie-Christine Machet, Anne Heitzmann, Serge Milin, Henri Sevestre, Catherine Godfraind, François Labrousse, Philippe Metellus, Didier Scavarda, Torsten Pietsch
Journal: Neuro-Oncology (2016)

Clear cell ependymoma is one of the 4 main histological subtypes of ependymomas defined by the World Health Organization (WHO) classification of tumors of the CNS. DNA methylation profiling can distinguish 4 subgroups of intracranial ependymomas, including supratentorial (ST) ependymomas with Yes-associated protein 1 fusion (YAP1), ST ependymomas with fusion of v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), posterior fossa ependymomas with balanced genome, and posterior fossa ependymomas with chromosomal instability. In addition, trisomy 19 is a genomic hallmark of ependymomas with rich branching capillaries. However, the relation of histological and molecular subtypes is unclear. Here, we report a series of 20 ependymomas histologically defined by clear cells and branching capillaries. We observed a strong male predominance. Median age at surgery was 10.4 years (range, 0.8–68.4). All cases were ST, cortical, contrast enhancing, and most often frontal, cystic, and calcified. All tumors qualified as WHO grade III. Some of them exhibited neuronal differentiation. Trisomy 19 was recorded in 13 cases. All samples strongly accumulated p65RelA protein within nuclei, indicating pathological activation of the nuclear factor-kappaB pathway. We identified causative C11ORF95-RELA fusion in almost all cases. Median progression-free survival and overall survival were 11.4 years (95% CI: 5.1–17.8) and not reached, respectively. ST clear cell ependymomas with branching capillaries display characteristic clinicopathological features and are associated with pathological activation of nuclear factor-kappaB signaling, which may indicate a potential novel target for therapy in these patients.
Treatment of Cancer-Associated Retinopathy With Rituximab
Authors: Irene Dy, Rangaswamy Chintapatla, Isabel Preeshagul, Daniel Becker
Journal: Journal of the National Comprehensive Cancer Network (2013)

Cancer-associated retinopathy (CAR) is a rare autoimmune condition associated with various cancers, causing significant visual impairment. Visual symptoms in CAR may or may not correlate with the extent of systemic disease or its response to chemotherapy, and must be addressed separately from the management of systemic malignancy. Steroids have been the mainstay of CAR therapy. Various immunomodulatory therapies have also been described with varying responses, but the overall visual prognosis remains poor. Rituximab is a monoclonal antibody used in the treatment of non-Hodgkin's B-cell lymphoma and many autoimmune disorders. This case report describes a patient with small cell uterine cancer who initially presented with visual impairment associated with CAR. The patient's deteriorating visual symptoms were successfully halted for an extended, clinically meaningful period with rituximab.
Brief Communication: A Possible Improvement in the Resolution of Proton Spin Relaxation for the Study of Cancer at Low Frequency 2
Authors: J. G. Diegel, M. M. Pintar
Journal: JNCI Journal of the National Cancer Institute (1975)

Available results indicate that the water proton spin-lattice relaxation time resolution, defined as [T1(tumorous) -T1(healthy)]/T1(tumorous), may increase if relaxation time is measured at 2 rather than at 30 MHz.
245P Predictive factor of metastatic castration-resistant prostate cancer patients' poor response to secondary alternative antiandrogen therapy with flutamide
Authors: M. Yasui, S. Yoneyama, K. Uemura, T. Kawahara, Y. Hattori, J.-I. Teranishi, J.-I. Ohta, Y. Yokomizo, Y. Masahiro, T. Masataka, H. Uemura, Y. Miyoshi
Journal: Annals of Oncology (2015)
A survey of tardive dyskinesia in psychiatric outpatients
Authors: G M Asnis, M A Leopold, R C Duvoisin, A H Schwartz
Journal: American Journal of Psychiatry (1977)

The authors found a high prevalence--43.4% of tardive dyskinesia in a sample of psychiatric outpatients, a population previously thought to be at nominal risk for development of this syndrome. There was no significant relationship between the presence of dyskinesia and age, sex, years of neuroleptic use, or various organic factors. The effects of dentures and of drug combinations are discussed, and it is noted that structured scales of dyskinesia and videotope recordings are important tools in diagnosing and following the course of dyskinesia.
Incidence and Clinical Features of Diabetic Ketoacidosis After Bariatric and Metabolic Surgery
Authors: Ali Aminian, Sangeeta R. Kashyap, Bartolome Burguera, Suriya Punchai, Gautam Sharma, Dvir Froylich, Stacy A. Brethauer, Philip R. Schauer
Journal: Diabetes Care (2016)

Bariatric surgery is considered an effective (1,2) and relatively safe (3) option for the treatment of obesity and its comorbidities, including type 1 and type 2 diabetes. Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes, which mainly occurs in patients with type 1 diabetes but can present in patients with type 2 diabetes under stressful conditions (4,5). The characteristics of early postoperative DKA following bariatric surgery are largely unknown. The objective of this study is to determine the incidence and clinical circumstances underlying DKA after bariatric surgery.

From January 2005 to December 2015, a total of 12 patients who developed DKA within 90 days following bariatric surgery at an academic center were identified in a database approved by an institutional review board. All patients met the American Diabetes Association criteria for the diagnosis of DKA (4,5). Two endocrinologists independently verified the diagnosis of DKA in the included patients. Baseline characteristics, intraoperative data, and postoperative outcomes were assessed.

Of the 12 patients who developed …
PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study
Authors: Sally F. Barrington, Amy A. Kirkwood, Antonella Franceschetto, Michael J. Fulham, Thomas H. Roberts, Helén Almquist, Eva Brun, Karin Hjorthaug, Zaid N. Viney, Lucy C. Pike, Massimo Federico, Stefano Luminari, John Radford, Judith Trotman, Alexander Fosså, Leanne Berkahn, Daniel Molin, Francesco D’Amore, Donald A. Sinclair, Paul Smith, Michael J. O’Doherty, Lindsey Stevens, Peter W. Johnson
Journal: Blood (2016)
B Cells (Cd20+) Associated to Tumor Infiltrating Cytotoxic T-Cells Observed on Resected Liver Colorectal Metastases (Lcm) are Prognostic
Authors: M. van den Eynde, B. Mlecnik, J. Machiels, D. Debetancourt, A. Jouret-Mourin, C. Sempoux, J. Gigot, C. Hubert, Y. Humblet, N. Haicheur, F. Marliot, F. Pagès, J. Galon
Journal: Annals of Oncology (2014)
Abstract 14914: VEGFR2 (Flk-1+/-) Gene Knockout Leads to Reduced Angiogenesis, Ventricular Dysfunction, and Alterations in Micro-RNA Profile Following Myocardial Infarction
Authors: Mandip Joshi, Mahesh Thirunavukkarasu, Vaithinathan Selvaraju, Juan J Sanchez, Nilanjana Maulik
Journal: Circulation (2012)
Vascular effects of sildenafil in patients with pulmonary fibrosis and pulmonary hypertension: an <i>ex vivo</i>/<i>in vitro</i> study
Authors: Javier Milara, Juan Escrivá, José Luis Ortiz, Gustavo Juan, Enrique Artigues, Esteban Morcillo, Julio Cortijo
Journal: European Respiratory Journal (2016)

Sildenafil improves the 6-min walking distance in patients with idiopathic pulmonary fibrosis (IPF) and right-sided ventricular systolic dysfunction.We analysed the previously unexplored role of sildenafil on vasoconstriction and remodelling of pulmonary arteries from patients with IPF and pulmonary hypertension (PH) ex vivo Pulmonary arteries from 18 donors without lung disease, nine IPF, eight PH+IPF and four PH patients were isolated to measure vasodilator and anti-contractile effects of sildenafil in isometric organ bath. Ventilation/perfusion was explored in an animal model of bleomycin lung fibrosis.Sildenafil relaxed serotonin (5-HT) pre-contracted pulmonary arteries in healthy donors and IPF patients and, to a lesser extent, in PH+IPF and PH. Sildenafil inhibited 5-HT dose-response contraction curve mainly in PH+IPF and PH, but not in healthy donors. Sildenafil did not impair the ventilation/perfusion mismatching induced by bleomycin. Pulmonary arteries from PH+IPF patients showed a marked expression of phosphodiesterse-5 and extracellular matrix components. Sildenafil inhibited pulmonary artery endothelial and smooth muscle cell to mesenchymal transition by inhibition of extracellular regulated kinases 1 and 2 (ERK1/2) and SMAD3 phosphorylation.These results suggest an absence of direct relaxant effect and a prominent anti-contractile and anti-remodelling role of sildenafil in PH+IPF pulmonary arteries that could explain the beneficial effects of sildenafil in IPF with PH phenotype.
Whole-Exome Sequencing of 8 Atypical Chronic Myeloid Leukaemia Patients,
Authors: Rocco Piazza, Simona Valletta, Alessandra Pirola, Hima Raman, Roberta Spinelli, Nick C.P. Cross, Caterina Cecchetti, Zaira Sortino, Carlo Gambacorti-Passerini
Journal: Blood (2011)
UTX demethylase activity is required for satellite cell–mediated muscle regeneration
Authors: Hervé Faralli, Chaochen Wang, Kiran Nakka, Aissa Benyoucef, Soji Sebastian, Lenan Zhuang, Alphonse Chu, Carmen G. Palii, Chengyu Liu, Brendan Camellato, Marjorie Brand, Kai Ge, F. Jeffrey Dilworth
Journal: Journal of Clinical Investigation (2016)

The X chromosome-encoded histone demethylase UTX (also known as KDM6A) mediates removal of repressive trimethylation of histone H3 lysine 27 (H3K27me3) to establish transcriptionally permissive chromatin. Loss of UTX in female mice is embryonic lethal. Unexpectedly, male UTX-null mice escape embryonic lethality due to expression of UTY, a paralog that lacks H3K27 demethylase activity, suggesting an enzyme-independent role for UTX in development and thereby challenging the need for active H3K27 demethylation in vivo. However, the requirement for active H3K27 demethylation in stem cell-mediated tissue regeneration remains untested. Here, we employed an inducible mouse KO that specifically ablates Utx in satellite cells (SCs) and demonstrated that active H3K27 demethylation is necessary for muscle regeneration. Loss of UTX in SCs blocked myofiber regeneration in both male and female mice. Furthermore, we demonstrated that UTX mediates muscle regeneration through its H3K27 demethylase activity, as loss of demethylase activity either by chemical inhibition or knock-in of demethylase-dead UTX resulted in defective muscle repair. Mechanistically, dissection of the muscle regenerative process revealed that the demethylase activity of UTX is required for expression of the transcription factor myogenin, which in turn drives differentiation of muscle progenitors. Thus, we have identified a critical role for the enzymatic activity of UTX in activating muscle-specific gene expression during myofiber regeneration and have revealed a physiological role for active H3K27 demethylation in vivo.
A transcatheter intracardiac shunt device for heart failure with preserved ejection fraction (REDUCE LAP-HF): a multicentre, open-label, single-arm, phase 1 trial
Authors: Gerd Hasenfuß, Chris Hayward, Dan Burkhoff, Frank E Silvestry, Scott McKenzie, Finn Gustafsson, Filip Malek, Jan Van der Heyden, Irene Lang, Mark C Petrie, John G F Cleland, Martin Leon, David M Kaye
Journal: The Lancet (2016)
First human face allograft: early report. Commentary
Authors: Patrick Warnke, H Carosella, D. Edgardo, Thomas Pradeu, Bernard Devauchelle, Lionel Badet, Benoit Lengele, Emmanuel Morelon, Sylvie Testelin, Mauricette Michallet, Cédric D.’Hauthuille
Journal: The Lancet (2006)
Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: outcomes by prior treatment
Authors: Paul G. Richardson, Vânia T. M. Hungria, Sung-Soo Yoon, Meral Beksac, Meletios Athanasios Dimopoulos, Ashraf Elghandour, Wieslaw W. Jedrzejczak, Andreas Guenther, Thanyaphong Na Nakorn, Noppadol Siritanaratkul, Robert L. Schlossman, Jian Hou, Philippe Moreau, Sagar Lonial, Jae Hoon Lee, Hermann Einsele, Monika Sopala, Bourras-Rezki Bengoudifa, Claudia Corrado, Florence Binlich, Jesús F. San-Miguel
Journal: Blood (2015)
Review of decision to restrict meningitis B vaccine to babies will report in summer
Authors: Adrian O’Dowd
Journal: BMJ (2016)

An expert group set up to review the methodology behind the United Kingdom’s decision to restrict access to the meningitis B vaccine to infants under 1 year old will report its findings in June, MPs have been told.

MPs on the health and petitions committees questioned experts and scientists on 22 March as part of their inquiry into an online petition that called for all children to be given the meningitis B vaccine up to at least age 11. The petition received a record breaking 823 342 signatures.

Infants aged under 1 have been eligible for the vaccine since September 2015, after an abbreviated schedule brought …