tbuckley/cabot-search huggingface dataset:
Association of Western and Traditional Diets With Depression and Anxiety in Women
Authors: Felice N. Jacka, Julie A. Pasco, Arnstein Mykletun, Lana J. Williams, Allison M. Hodge, Sharleen Linette O'Reilly, Geoffrey C. Nicholson, Mark A. Kotowicz, Michael Berk
Journal: American Journal of Psychiatry (2010)

Objective Key biological factors that influence the development of depression are modified by diet. This study examined the extent to which the high-prevalence mental disorders are related to habitual diet in 1,046 women ages 20–93 years randomly selected from the population. Method A diet quality score was derived from answers to a food frequency questionnaire, and a factor analysis identified habitual dietary patterns. The 12-item General Health Questionnaire (GHQ-12) was used to measure psychological symptoms, and a structured clinical interview was used to assess current depressive and anxiety disorders. Results After adjustments for age, socioeconomic status, education, and health behaviors, a "traditional" dietary pattern characterized by vegetables, fruit, meat, fish, and whole grains was associated with lower odds for major depression or dysthymia and for anxiety disorders. A "western" diet of processed or fried foods, refined grains, sugary products, and beer was associated with a higher GHQ-12 score. There was also an inverse association between diet quality score and GHQ-12 score that was not confounded by age, socioeconomic status, education, or other health behaviors. Conclusions These results demonstrate an association between habitual diet quality and the high-prevalence mental disorders, although reverse causality and confounding cannot be ruled out as explanations. Further prospective studies are warranted.
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
Authors: M Cella, D Scheidegger, K Palmer-Lehmann, P Lane, A Lanzavecchia, G Alber
Journal: The Journal of Experimental Medicine (1996)

We investigated the possibility that T helper cells might enhance the stimulatory function of dendritic cells (DCs). We found that ligation of CD40 by CD40L triggers the production of extremely high levels of bioactive IL-12. Other stimuli such as microbial agents, TNF-alpha or LPS are much less effective or not at all. In addition, CD40L is the most potent stimulus in upregulating the expression of ICAM-1, CD80, and CD86 molecules on DCs. These effects of CD40 ligation result in an increased capacity of DCs to trigger proliferative responses and IFN-gamma production by T cells. These findings reveal a new role for CD40-CD40L interaction in regulating DC function and are relevant to design therapeutic strategies using cultured DCs.
Invasive Lobular Carcinoma Classic Type: Response to Primary Chemotherapy and Survival Outcomes
Authors: Massimo Cristofanilli, Ana Gonzalez-Angulo, Nour Sneige, Shu-Wan Kau, Kristine Broglio, Richard L. Theriault, Vicente Valero, Aman U. Buzdar, Henry Kuerer, Thomas A. Buccholz, Gabriel N. Hortobagyi
Journal: Journal of Clinical Oncology (2004)

To investigate the impact of histologic type invasive lobular carcinoma (ILC) versus invasive ductal carcinoma (IDC) on response to primary chemotherapy (PC) and long-term outcome.The study included 1,034 patients with stage II and III breast cancer who participated in six clinical trials of PC at our institution between 1985 and 2002. One hundred twenty-two patients (12%) had ILC and 912 (88%) had IDC. All patients received anthracycline-based PC, and 346 patients (33.5%) also received a taxane as part of PC. Pathologic complete response (pCR) was defined as no evidence of invasive disease in the breast and axillary lymph nodes.The median patient age was 48 years (range, 18 to 79 years). Patients with ILC tended to be older (median age, 53 years v 47 years for patients with IDC) and have more hormone-receptor-positive tumors (92% v 62%; P < .001), lower nuclear grade (nuclear grade 3, 16% v 56%; P < .001), and higher stage at diagnosis (10% v 0% with stage IIIB or IIIC disease; P < .001). Patients with ILC were less likely to have a pCR (3% v 15%; P < .001) and had a larger number of involved axillary lymph nodes (41% v 26% had > 3 involved nodes; P = .001). At a median follow-up time of 70 months, ILC patients tended to have longer recurrence-free survival (P = .004) and overall survival (P = .001).ILC is characterized by lower rates of pathologic response to PC but better long-term outcomes compared to IDC. pCR might not be a prognostic indicator for this group of patients.
The effect of oxidative stress polymorphisms on the association between long-term black carbon exposure and lung function among elderly men
Authors: Irina Mordukhovich, Johanna Lepeule, Brent A Coull, David Sparrow, Pantel Vokonas, Joel Schwartz
Journal: Thorax (2014)

<h3>Background</h3> Black carbon (BC) is a pro-oxidant, traffic-related pollutant linked with lung function decline. We evaluated the influence of genetic variation in the oxidative stress pathway on the association between long-term BC exposure and lung function decline. <h3>Methods</h3> Lung function parameters (FVC and FEV<sub>1</sub>) were measured during one or more study visits between 1995 and 2011 (n=651 participants) among an elderly cohort: the Normative Aging Study. Residential BC exposure levels were estimated using a spatiotemporal land use regression model. We evaluated whether oxidative stress variants, combined into a genetic score, modify the association between 1-year and 5-year moving averages of BC exposure and lung function levels and rates of decline, using linear mixed models. <h3>Results</h3> We report stronger associations between long-term BC exposure and increased rate of lung function decline, but not baseline lung function level, among participants with higher oxidative stress allelic risk profiles compared with participants with lower risk profiles. Associations were strongest when evaluating 5-year moving averages of BC exposure. A 0.5 µg/m<sup>3</sup> increase in 5-year BC exposure was associated with a 0.1% yearly increase in FVC (95% CI −0.5 to 0.7) among participants with low genetic risk scores and a 1.3% yearly decrease (95% CI −1.8 to −0.8) among those with high scores (p-interaction=0.0003). <h3>Discussion</h3> Our results suggest that elderly men with high oxidative stress genetic scores may be more susceptible to the effects of BC on lung function decline. The results, if confirmed, should inform air-quality recommendations in light of a potentially susceptible subgroup.
Gene Expression Profiles of B-lineage Adult Acute Lymphocytic Leukemia Reveal Genetic Patterns that Identify Lineage Derivation and Distinct Mechanisms of Transformation
Authors: Sabina Chiaretti, Xiaochun Li, Robert Gentleman, Antonella Vitale, Kathy S. Wang, Franco Mandelli, Robin Foà, Jerome Ritz
Journal: Clinical Cancer Research (2005)

Abstract Purpose: To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. Experimental Design: Gene expression profiles from 128 adult patients with newly diagnosed ALL were characterized using high-density oligonucleotide microarrays. All patients were enrolled in the Italian GIMEMA multicenter clinical trial 0496 and samples had &amp;gt;90% leukemic cells. Uniform phenotypic, cytogenetic, and molecular data were also available for all cases. Results: T-lineage ALL was characterized by a homogeneous gene expression pattern, whereas several subgroups of B-lineage ALL were evident. Within B-lineage ALL, distinct signatures were associated with ALL1/AF4 and E2A/PBX1 gene rearrangements. Expression profiles associated with ALL1/AF4 and E2A/PBX1 are similar in adults and children. BCR/ABL+ gene expression pattern was more heterogeneous and was most similar to ALL without known molecular rearrangements. We also identified a set of 83 genes that were highly expressed in leukemia blasts from patients without known molecular abnormalities who subsequently relapsed following therapy. Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. Two other kinases (PRKCB1 and DDR1) were highly expressed in cases without molecular rearrangements, as well as in BCR/ABL-positive ALL. Conclusions: Genomic signatures are associated with phenotypically and molecularly well defined subgroups of adult ALL. Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL.
Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials
Authors: L. Hooper, G. Madhavan, J. A. Tice, S. J. Leinster, A. Cassidy
Journal: Human Reproduction Update (2010)

Isoflavones from soy and red clover exert modest hormonal effects in women, but the relevance to risk of breast cancer is unclear. The aim of this meta-analysis was to assess the effects of isoflavone-rich foods or supplements on a biomarker of breast cancer risk, women's mammographic density. Electronic searches were performed on The Cochrane Library, Medline and EMBASE (to June 2009), and reference lists and trial investigators were consulted to identify further studies. Randomized controlled trials (RCTs) of isoflavone-rich foods or supplements versus placebo with a duration of at least 6 months were included in our analysis. Inclusion/exclusion, data extraction and validity assessment were carried out independently in duplicate, and meta-analysis used to pool study results. Subgrouping, sensitivity analysis, assessment of heterogeneity and funnel plots were used to interpret the results. Eight RCTs (1287 women) compared isoflavones with placebo for between 6 months and 3 years. Meta-analysis suggested no overall effect of dietary isoflavones on breast density in all women combined [mean difference (MD) 0.69%, 95% confidence interval (CI) −0.78 to 2.17] or post-menopausal women (MD −1.10%, 95% CI −3.22 to 1.03). However, there was a modest increase in mammographic density in premenopausal women (MD 1.83%, 95% CI 0.25–3.40) without heterogeneity but this effect was lost in one of three sensitivity analyses. Isoflavone intake does not alter breast density in post-menopausal women, but may cause a small increase in breast density in premenopausal women. Larger, long-term trials are required to determine if these small effects are clinically relevant.
Do we alter ultraviolet sensitivity in vivo with stratum corneum rehydration? A pilot study and review of the literature
Authors: S.C. Behrens-Williams, D. Kraus, T. Reuther, M.J. Kerscher
Journal: British Journal of Dermatology (2002)

Journal Article Do we alter ultraviolet sensitivity in vivo with stratum corneum rehydration? A pilot study and review of the literature Get access S.C. Behrens‐Williams, S.C. Behrens‐Williams University of Hamburg, Department of Cosmetic Sciences, von Melle Park 8 (FB 13), D‐20146 Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar D. Kraus, D. Kraus University of Hamburg, Department of Cosmetic Sciences, von Melle Park 8 (FB 13), D‐20146 Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar T. Reuther, T. Reuther University of Hamburg, Department of Cosmetic Sciences, von Melle Park 8 (FB 13), D‐20146 Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar M.J. Kerscher M.J. Kerscher University of Hamburg, Department of Cosmetic Sciences, von Melle Park 8 (FB 13), D‐20146 Hamburg, Germany Professor Martina Kerscher E‐mail: martina.kerscher@uni‐hamburg.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 2, 1 February 2002, Pages 280–284, https://doi.org/10.1046/j.1365-2133.2002.04585.x Published: 01 February 2002 Article history Accepted: 01 October 2001 Published: 01 February 2002
Does Sex Affect Survival of Patients With Squamous Cell Esophageal Cancer?
Authors: Jie Zhang, David Garfield, Yizhou Jiang, Shengfei Wang, Sufeng Chen, Haiquan Chen
Journal: Journal of Clinical Oncology (2013)

those for which no compensation was received; those relationships marked with a "C" were compensated.For a detailed description of the disclosure categories, or for more information
Boosting with stumps for predicting transcription start sites.
Authors: Xiaoyue Zhao, Zhenyu Xuan, Michael Q Zhang
Journal: Genome biology (2007)

Abstract Promoter prediction is a difficult but important problem in gene finding, and it is critical for elucidating the regulation of gene expression. We introduce a new promoter prediction program, CoreBoost, which applies a boosting technique with stumps to select important small-scale as well as large-scale features. CoreBoost improves greatly on locating transcription start sites. We also demonstrate that by further utilizing some tissue-specific information, better accuracy can be achieved.
Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells
Authors: Purevdorj B. Olkhanud, Bazarragchaa Damdinsuren, Monica Bodogai, Ronald E. Gress, Ranjan Sen, Katarzyna Wejksza, Enkhzol Malchinkhuu, Robert P. Wersto, Arya Biragyn
Journal: Cancer Research (2011)

Abstract Pulmonary metastasis of breast cancer requires recruitment and expansion of T-regulatory cells (Treg) that promote escape from host protective immune cells. However, it remains unclear precisely how tumors recruit Tregs to support metastatic growth. Here we report the mechanistic involvement of a unique and previously undescribed subset of regulatory B cells. These cells, designated tumor-evoked Bregs (tBreg), phenotypically resemble activated but poorly proliferative mature B2 cells (CD19+ CD25High CD69High) that express constitutively active Stat3 and B7-H1High CD81High CD86High CD62LLow IgMInt. Our studies with the mouse 4T1 model of breast cancer indicate that the primary role of tBregs in lung metastases is to induce TGF-β–dependent conversion of FoxP3+ Tregs from resting CD4+ T cells. In the absence of tBregs, 4T1 tumors cannot metastasize into the lungs efficiently due to poor Treg conversion. Our findings have important clinical implications, as they suggest that tBregs must be controlled to interrupt the initiation of a key cancer-induced immunosuppressive event that is critical to support cancer metastasis. Cancer Res; 71(10); 3505–15. ©2011 AACR.
Targeted Inhibition of the KLF6 Splice Variant, KLF6 SV1, Suppresses Prostate Cancer Cell Growth and Spread
Authors: Goutham Narla, Analisa DiFeo, Shen Yao, Asoka Banno, Eldad Hod, Helen L. Reeves, Rui F. Qiao, Olga Camacho-Vanegas, Alice Levine, Alexander Kirschenbaum, Andrew M. Chan, Scott L. Friedman, John A. Martignetti
Journal: Cancer Research (2005)

Abstract Prostate cancer is a leading cause of cancer death in men. Risk prognostication, treatment stratification, and the development of rational therapeutic strategies lag because the molecular mechanisms underlying the initiation and progression from primary to metastatic disease are unknown. Multiple lines of evidence now suggest that KLF6 is a key prostate cancer tumor suppressor gene including loss and/or mutation in prostate cancer tumors and cell lines and decreased KLF6 expression levels in recurrent prostate cancer samples. Most recently, we identified a common KLF6 germ line single nucleotide polymorphism that is associated with an increased relative risk of prostate cancer and the increased production of three alternatively spliced, dominant-negative KLF6 isoforms. Here we show that although wild-type KLF6 (wtKLF6) acts as a classic tumor suppressor, the single nucleotide polymorphism-increased splice isoform, KLF6 SV1, displays a markedly opposite effect on cell proliferation, colony formation, and invasion. In addition, whereas wtKLF6 knockdown increases tumor growth in nude mice &amp;gt;2-fold, short interfering RNA–mediated KLF6 SV1 inhibition reduces growth by ∼50% and decreases the expression of a number of growth- and angiogenesis-related proteins. Together, these findings begin to highlight a dynamic and functional antagonism between wtKLF6 and its splice variant KLF6 SV1 in tumor growth and dissemination.
Methylenetetrahydrofolate Reductase Genotypes and Early-Onset Coronary Artery Disease
Authors: Aviv Mager, Shadan Lalezari, Tamar Shohat, Yochai Birnbaum, Yehuda Adler, Nurit Magal, Mordechai Shohat
Journal: Circulation (1999)

Homozygosity for the common (677C-->T) mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with hyperhomocysteinemia, but there is uncertainty as to the association between this mutation and coronary artery disease (CAD). This study examined the association between MTHFR genotypes and age at onset of CAD.Patients (n=169) with documented myocardial infarction or angiographically documented CAD who were aged < or = 55 years at onset of CAD symptoms and DNA samples from control subjects (n=313) were studied. The prevalence of homozygosity among patients with early CAD onset (aged < or = 45 years) was 28%, which was significantly higher than that in patients with later onset (13%) and in control subjects (14%) (odds ratio 2.4, 95% CI 1.24 to 4.69, P=0.006, and odds ratio 2.7, 95% CI 1.15 to 6.42, P=0.01, respectively). Plasma folate was lower in TT homozygotes who had early CAD onset than in those with later onset (P=0.005). Among patients with plasma folate in the lowest quintile (< or = 12.6 nmol/L), 31% were homozygotes, as were 45% of those with low plasma folate and early CAD onset. There was no difference in the prevalence of traditional risk factors among genotypes. The frequency of homozygosity in patients with < or = 1 risk factor was higher than in those with > or = 2 risk factors (30% versus 12%, P<0.05). In multiple regression analysis, TT homozygosity and plasma folate were independently associated with CAD, but the impact of folate was small.Homozygosity for the 677C-->T mutation of MTHFR is common and is associated with an increased risk of premature CAD in this population.
Carboplatin/cyclophosphamide or carboplatin/paclitaxel in elderly patients with advanced ovarian cancer? Analysis of two consecutive trials from the Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens
Authors: O. Trédan, J.-F. Geay, S. Touzet, R. Delva, B. Weber, J. Cretin, J. Provencal, J. Martin, L. Stefani, E. Pujade-Lauraine, G. Freyer
Journal: Annals of Oncology (2006)
Trilene as an Analgesic in Labour
Authors: F. N. Reynolds
Journal: BMJ (1949)

An account of the investigation into the possible use of trilene by midwives as an analgesic in labour has been issued by the Royal College of Obstetricians and Gynaecologists.The report does not seem to have received the publicity in the medical press which it demands.A standard method of administra- tion by means of the modified Freedman's inhaler was adopted and efficacy, effect on labour, and safety for mother and child were investigated.Results of Investigation The results, in brief, arrived at under these headings were as follows:Efficacy.-Adequaterelief can be given to a high proportion of cases-76% to 89%-without any special skill upon the part of the administrator.The degree of analgesia provided was superior to that obtained from gas and air by Minnitt's method.Eflect on Laboutr.-Noevidence was adduced of any adverse effect upon length of labour, forceps rate, or obstetrical interference rate.No case of diminution of uterine contractions due to trilene was recorded, but in three cases out of 1,168 unexplained delay might have been attributable to the analgesic.A small proportion-4.6%-of patients became uncooperative mainly because they became too sleepy to push in the second stage.This incidence did not appear to have any relation to the duration of the trilene analgesia.Safety to Mothers.-In the group to which trilene alone was given there was one maternal death-a rate of 0.86 per 1,000-and that on the fourth day of the puerperium in a patient with mitral stenosis.In marked contrast the death rate was more than doubled-106 per 1,000-in the group to whom no analgesic or anaesthetic of any sort was given.
Variation in Colonization, ADP-Ribosylating and Vacuolating Cytotoxin, and Pulmonary Disease Severity among <i>Mycoplasma pneumoniae</i> Strains
Authors: Chonnamet Techasaensiri, Claudia Tagliabue, Marianna Cagle, Pooya Iranpour, Kathy Katz, Thirumalai R. Kannan, Jacqueline J. Coalson, Joel B. Baseman, R. Doug Hardy
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Mycoplasma pneumoniae was recently discovered to produce an ADP-ribosylating and vacuolating cytotoxin, designated CARDS toxin, which is hypothesized to be a primary pathogenic mechanism responsible for M. pneumoniae-induced pulmonary inflammation. It is unknown if cytotoxin production varies with M. pneumoniae strain or if variation in cytotoxin production affects pulmonary disease severity.To examine the production of CARDS toxin by various strains of M. pneumoniae and compare the disease manifestations elicited by these strains in an experimental model of M. pneumoniae respiratory infection.BALB/c mice were inoculated once intranasally with SP4 broth (negative control) or three different M. pneumoniae strains: M129-B7, M129-B9, or S1. Mice were assessed at 1, 2, 4, 7, 10, and 14 days after inoculation. Outcome variables included comparisons among M. pneumoniae strains relative to bronchoalveolar lavage (BAL) M. pneumoniae quantitative culture, CARDS toxin-based PCR, and CARDS toxin protein determinations, as well as cytokine and chemokine concentrations. Graded lung histopathologic score (HPS) was also assessed.CARDS toxin concentrations were significantly increased in mice inoculated with strain S1 compared with mice inoculated with M129-B7 or M129-B9 strains. Quantitative M. pneumoniae culture and polymerase chain reaction were also significantly greater in mice infected with S1 strain compared with the other two strains, as were lung HPS and concentrations of IFN-γ, IL-12, IL-1α, macrophage inflammatory protein-1α, and keratinocyte-derived chemokine. In addition, a significant positive correlation was found between CARDS toxin concentration and lung HPS.CARDS toxin concentrations in BAL are directly linked to the ability of specific M. pneumoniae strains to colonize, replicate, and persist, and elicit lung histopathology. This variation among strains may predict the range in severity of pulmonary disease observed among patients.