tbuckley/cabot-search huggingface dataset:
Data on trial of anticoagulant is to be reanalyzed after discovery that investigators used faulty device
Authors: Deborah Cohen
Journal: BMJ (2015)

Data from the key phase III trial that allowed the oral anticoagulant rivaroxaban on to the market for the prevention of ischemic stroke in non-valvular atrial fibrillation is being reanalyzed because of the use of a faulty device.

The European Medicines Agency has also told The BMJ that it has launched an investigation into the trial.

The ROCKET-AF trial, published in the New England Journal of Medicine in 2011, compared rivaroxaban, which is manufactured by Bayer and marketed in the United States by Janssen, part of Johnson and Johnson, as Xarelto, with warfarin in more than 14 000 people.1

The trial used the INRatio device, made by Alere, to determine whether, and by how much, patients’ doses of warfarin should be adjusted to keep the drug in the right therapeutic range. Too much warfarin and patients are at an increased risk of bleeding; too little and they are at risk of clots.

However, The BMJ has …
Challenges for Restoration of Lower Urinary Tract Innervation in Patients with Spinal Cord Injury: A European Single-center Retrospective Study with Long-term Follow-up
Authors: Karl-Dietrich Sievert, Bastian Amend, Florian Roser, Andreas Badke, Patricia Toomey, Christopher Baron, Jan Kaminsky, Arnulf Stenzl, Marcos Tatagiba
Journal: European Urology (2015)
WITHDRAWN: Memantine uptake mediated by a functionally diverse proton-coupled organic cation antiporter in human brain endothelial cells
Authors: Kei Higuchi, Takashi Okura, Yoshiharu Deguchi
Journal: Asian Journal of Pharmaceutical Sciences (2015)

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
<i>Annals</i> Graphic Medicine - The Last Ride of Mo Rosenzweig
Authors: Sharon Rosenzweig, Aaron Freeman
Journal: Annals of Internal Medicine (2015)

Web Exclusives1 December 2015Annals Graphic Medicine - The Last Ride of Mo RosenzweigFREESharon Rosenzweig, BFA, MFA and Aaron FreemanSharon Rosenzweig, BFA, MFASearch for more papers by this author and Aaron FreemanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G15-0005 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Albert FuchsAlbert Fuchs, MD4 December 2015 Thank you That was poignant and sad. My thanks to the authors. Author, Article, and Disclosure InformationAuthors: Sharon Rosenzweig, BFA, MFA; Aaron FreemanDisclosures: The authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G15-0005.Author Information: Sharon Rosenzweig is an investigative cartoonist (thecomictorah.com), and Aaron Freeman is artist in residence at the Chicago Council on Science and Technology.Corresponding Author: Sharon Rosenzweig; e-mail, [email protected]com.Author Contributions: Conception and design: A. Freeman, S. Rosenzweig.Analysis and interpretation of the data: A. Freeman, S. Rosenzweig.Drafting of the article: A. Freeman, S. Rosenzweig.Critical revision for important intellectual content: A. Freeman, S. Rosenzweig.Final approval of the article: A. Freeman, S. Rosenzweig.Provision of study materials or patients: S. Rosenzweig.Collection and assembly of data: A. Freeman, S. Rosenzweig.Art by Sharon Rosenzweig, BFA, MFA, and written and edited by Aaron Freeman. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 2015Volume 163, Issue 11Page: W146-W151KeywordsConflicts of interestDisclosureHealth careInformation technology ePublished: 1 December 2015 Issue Published: 1 December 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Preclinical testing of a novel personalized cancer vaccine for all solid tumors and all patients
Authors: Doreen Jackson, Julia M Greene, Diane Hale, Erika Schneble, Thomas Wagner, Xianzhong Yu, George E Peoples
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts A variety of autologous tumor/dendritic-cell (DC) vaccines have been pursued. Our prior autologous tumor/DC fusion (dendritoma) vaccine demonstrated clinical benefit in metastatic melanoma; however, dendritoma production is difficult and not scalable for commercialization. We
Suicide and the dexamethasone suppression test in unipolar depression
Authors: W Coryell, M A Schlesser
Journal: American Journal of Psychiatry (1981)

The authors studied 243 inpatients with unipolar depression who had received DSTs. Of 205 patients with primary depression, the 4 who later committed suicide were among 96 with abnormal DST results; 1 patients with secondary depression committed suicide despite a normal DST result. The authors suggest that hypothalamic-pituitary-adrenal dysfunction is associated with a type of primary depressive illness that is more likely to involve suicide than are other types.
Role of helicobacter pylori in functional dyspepsia
Authors: K Nagpal, UK Shrivastava, A Gupta, A Gupta, A Bhatia
Journal: Endoscopy (2006)

Methods: Eighty patients of functional dyspepsia were included and upper gastrointestinal endoscopy (UGIE) was done. Antral biopsies were taken to test the presence of Helicobacter pylori. Their symptoms were scored on adjectival scale and visual analogue scale. All patients were randomly distributed into 2 groups. One group received drug treatment for H. pylori for one week and second group received placebo therapy. Patients were re-evaluated in terms of symptoms scores at one month and at three months. Change in dyspepsia score was compared using ANOVA test.
An open label randomized Phase III trial of nivolumab or nivolumab plus ipilimumab vs platinum doublet chemotherapy (PT-DC) in patients with chemotherapy-naïve stage IV or recurrent non-small cell lung cancer (NSCLC) (CheckMate 227)
Authors: Matthew Hellmann, Suresh Ramalingam, Martin Reck, Ken O'Byrne, Luis Paz-Ares, Christopher T Harbison, Prabhu Bhagavatheeswaran, Faith Nathan, Julie Brahmer
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Patients with advanced NSCLC are treated with first-line PT-DC, which is associated with a median OS of 8–10 months and 1-year and 2-year survival rates of 30–40% and 10–15%, respectively. Nivolumab (a fully human IgG4 anti-programmed death-1 immune checkpoint inhibitor
Scintigraphic Detection of Infection and Inflammation
Authors: C. P. Bleeker-Rovers, F. J. Vos, F. H. M. Corstens
Journal: Clinical Nuclear Medicine (2008)

Nuclear medicine techniques have a lot to offer in visualization of infectious and inflammatory foci. Quite often these techniques do not lead immediately to a definitive diagnosis, i.e., a histological or a microbiological diagnosis. However, they point to parts in the body where a particular metabolic process is ongoing, leading to elevated uptake of a radiopharmaceutical. With the help of other techniques, such as puncture, biopsy and culture, a definitive diagnosis can be obtained. In other words, scintigraphic imaging helps to elucidate the cause of the disease, and facilitates prompt installation of a tailored therapeutic regimen. Furthermore, with these techniques it is possible to monitor the effect of therapy.
Le Programme de formation à l'épidémiologie de terrain (FETP) en Allemagne
Authors: L R Petersen, T Breuer, O Hamouda, A Ammon
Journal: Eurosurveillance (2001)

Le Programme allemand de formation a l’epidemiologie de terrain (Field Epidemiology Training Programme, FETP) a debute en janvier 1996. Il entre dans le cadre de l’effort national visant a ameliorer la capacite de recherche en epidemiologie des maladies infectieuses en Allemagne (1). Ce programme, d’une duree de deux ans, a pour but de developper un reseau d’epidemiologistes capables de mener des investigations d’epidemies, des recherches epidemiologiques, ainsi qu’une surveillance internationale evaluee par des articles publies dans des revues internationales soumises a la relecture scientifique. Il sera egalement demande a ces epidemiologistes de former de futurs confreres et des agents de sante publique. Le Programme est identique d’une part, a celui du Service d’Investigation Epidemique (EIS) du CDC (Centers for Disease Control and Prevention) aux Etats-Unis, et d’autre part, au Programme europeen de formation a l’epidemiologie d’intervention (EPIET) (2,3). Le Ministere federal allemand de la recherche et de l’education a finance le poste d’un epidemiologiste senior afin de mettre en place ce programme a l’aide du CDC.
Hematologic Response To Oral Azacitidine (CC-486) In Subjects With WHO-Defined RAEB-1 Or RAEB-2 Myelodysplastic Syndromes (MDS)
Authors: Guillermo Garcia -Manero, Michael Savona, Steven D. Gore, Christopher R. Cogle, Paul Conkling, CL Beach, Joel Hetzer, Qian Dong, Barry S. Skikne
Journal: Blood (2013)
A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infection.
Authors: E Y Denkers, T Scharton-Kersten, S Barbieri, P Caspar, A Sher
Journal: The Journal of Experimental Medicine (1996)

Major histocompatibility complex (MHC) class II (A beta) knockout mice were vaccinated with ts-4, an attenuated mutant strain of Toxoplasma gondii, which in normal animals induces strong T cell immunity mediated by interferon gamma (IFN-gamma). After challenge with the lethal parasite strain RH, the knockout mice displayed decreased resistance consistent with absence of CD4+ effectors. Nevertheless, these animals generated CD8+ lymphocyte effectors capable of mediating partial protection through IFN-gamma secretion. Moreover, in vivo neutralization experiments indicated that the development of resistance in knockout mice depends on CD4+ cells as well as interleukin 2 (IL-2). The identity of the IL-2-producing protective cell population was further characterized as CD4+, NK1.1+ by in vitro depletion studies and reverse transcriptase-PCR analysis of fluorescence-activated cell sorter (FACS)-purified CD4+ NK1.1+ T lymphocytes. These results demonstrate that in the absence of conventional MHC class II-restricted CD4+ T lymphocytes, CD8 priming persists and mediates partial protective immunity to T. gondii. Moreover, the data argue that CD4+, NK1.1+ cells, previously implicated in the initiation of T helper cell 2 (Th2) responses through their production of IL-4, can also play a role as alternative IL-2-secreting helper cells in Th1-mediated host resistance to infection.
Productive infection and Morphologic Alteration of Human Cells by a Modified Sarcoma Virus
Authors: Peter J. Fischinger, Timothy E. O'Connor
Journal: JNCI Journal of the National Cancer Institute (1970)

Murine sarcoma virus apparently coated with feline leukemia virus envelope [MSV (FelLV)] could, in association with feline leukemia virus, morphologically alter and actively replicate in various human cell cultures. New defective MSV (FelLV) and cat leukemia virus, which could grow in both cat cells and human cells, were produced. MSV (FelLV) exhibited selective tissue tropism and required active cell growth. Human embryo cultures could be chronically infected with either MSV (FelLV) or FelLV alone. In human embryonic lung cells, a cell-free passage of the MSV (FelLV) virus complex could be established. Cat leukemia virus per se could also infect productively some human cells as determined by the induction of new helper virus for defective MSV (FelLV).
Effect of Transmyocardial Laser Revascularization on Ischemic Cardiomyopathy in a Sheep
Authors: S Ozaki, Bart Meyns, R Racz, Eric Verbeken, Leunens, P Dohmen, Willem Flameng
Journal: Circulation (1999)

Methods Ischemic cardiomyopathy was induced in eleven sheep by the application of coronary stenosis (CS) on the left anterior descending (LAD) and circumflex coronary artery (LCX). Ten weeks later, TMR was performed by a Holmium YAG laser (n=6). Transmyocardial channels were created in the anterior free wall of the left ventricle (n=43 ± 8.4 channels per square centimeter) and in the posterior wall (n=10). Five animals served as controls. Myocardial function was analyzed by echocardiography taken at baseline and every second week after CS and after TMR. Myocardial perfusion was measured by colored microspheres, injected at baseline, immediately after CS, before and after TMR and at 20 weeks after CS. The hearts were retrieved at 20 weeks for light microscopic examination. Results Wall thickening fraction (WTF) decreased significantly (P < 0.01) during 10 weeks after CS and left ventricular end-diastolic cavity area (EDCA) increased progressively (P < 0.05). WTF was Immediately reduced by TMR and recovered gradually to the pre TMR level. No significant difference was observed in WTF between TMR and control group nor between the anterior and the posterior wall in TMR group. EDCA after TMR remained higher compared with the baseline value and the same as control group during 20 weeks after CS. Myocardial blood flow (MBF) was significantly decreased in the LAD (P < 0.01) and LCX territory (P < 0.05) at 10 weeks after CS, and progressively increased to baseline level in both areas after TMR. However, there was no significant difference between groups. Light microscopical examination revealed channel patency in 49.4%. A dense capillary network was observed at the edges of the surounding scar.
Randomized controlled trials in cancer: Improving the quality of their reports will also facilitate better conduct
Authors: D. Moher, K.F. Schulz
Journal: Annals of Oncology (1998)

There has been a renewed interest in ways to help improve the quality of reports of clinical trials recently. In this paper we describe these developments. This work has also focused increased attention on how clinical trials are planned and executed. Some common problems are reviewed and suggestions for improving their conduct are also discussed.
Prognostic Value of Cardiac Troponin in Patients With Chronic Kidney Disease Without Suspected Acute Coronary Syndrome
Authors: Erin D. Michos, Lisa M. Wilson, Hsin-Chieh Yeh, Zackary Berger, Catalina Suarez-Cuervo, Sylvie R. Stacy, Eric B. Bass
Journal: Annals of Internal Medicine (2020)

The prognostic value of troponin testing in patients with chronic kidney disease (CKD) without suspected acute coronary syndrome (ACS) is uncertain. This systematic review of 98 observational studi...
Paclitaxel by 24-hour infusion with doxorubicin by 48-hour infusion as initial therapy for metastatic breast cancer: Phase I results
Authors: F A Holmes, V Valero, R S Walters, R L Theriault, D J Booser, H Gibbs, G Fraschini, A U Buzdar, J Willey, D Frye, L Asmar, G N Hortobagyi
Journal: Annals of Oncology (1999)
Mortality in end-stage renal disease is associated with facility-to-facility differences in adequacy of hemodialysis.
Authors: W M McClellan, J M Soucie, W D Flanders
Journal: Journal of the American Society of Nephrology (1998)

Death rates of end-stage renal disease (ESRD) patients treated with hemodialysis vary substantially among treatment centers. The association between facility-to-facility differences in delivered hemodialysis dose and facility-specific mortality rates was examined among 5817 randomly selected patients treated with hemodialysis on October 1, 1994, from all 213 hemodialysis treatment centers reporting to ESRD Network 6. The mean urea reduction ratio (URR) for each treatment center, a measure of hemodialysis adequacy, was calculated for each facility, using measurements made by center staff members during one treatment for each of the randomly selected patients. During 7 mo of follow-up (ending April 30, 1995), 441 (7.6%) patients died. The average URR among the treatment centers was 64.9%. There was a strong, inverse association between increasing treatment center URR and adjusted mortality count (P = 0.009). Other treatment center characteristics associated with increased mortality included free-standing status (P = 0.009) and decreasing frequency of reported physician supervision of care (P = 0.01). It was concluded that lower average levels of dialysis adequacy in treatment centers are associated with higher rates of death, and this association persists after controlling for facility-to-facility differences in patient and nonpatient characteristics.
Pubic apophysitis: a previously undescribed clinical entity of groin pain in athletes
Authors: Matthieu Sailly, Rod Whiteley, John W Read, Bruno Giuffre, Amanda Johnson, Per Hölmich
Journal: British Journal of Sports Medicine (2015)

Sport-related pubalgia is often a diagnostic challenge in elite athletes. While scientific attention has focused on adults, there is little data on adolescents. Cadaveric and imaging studies identify a secondary ossification centre located along the anteromedial corner of pubis beneath the insertions of symphysial joint capsule and adductor longus tendon. Little is known about this apophysis and its response to chronic stress.We report pubic apophysitis as a clinically relevant entity in adolescent athletes.The clinical and imaging findings in 26 highly trained adolescent football players (15.6 years ± 1.3) who complained of adductor-related groin pain were reviewed. The imaging features (X-ray 26/26, US 9/26, MRI 11/26, CT 7/26) of the pubic apophyses in this symptomatic group were compared against those of a comparison group of 31 male patients (age range 9-30 years) with no known history of groin pain or pelvic trauma, who underwent pelvic CT scans for unrelated medical reasons.All symptomatic subjects presented with similar history and physical findings. The CT scans of these patients demonstrated open pubic apophyses with stress-related physeal changes (widening, asymmetry and small rounded cyst-like expansions) that were not observed in the comparison group. No comparison subject demonstrated apophyseal maturity before 21 years of age, and immaturity was seen up to the age of 26 years.This retrospective case series identifies pubic apophyseal stress (or 'apophysitis') as an important differential consideration in the adolescent athlete who presents with groin pain.
677. Interleukin-1 Silencing in Osteoarthritic Models Using Plasmid and Integrating Transposon Based RNA Interference
Journal: Molecular Therapy (2009)

To be effective in vivo, plasmid based IL-1 silencing is necessary to overcome the transitory nature of oligo based knockdown. The hypothesis for this study was that IL-1 expression could be better controlled using short hairpin plasmid and ultimately integrating transposon plasmid based gene silencing motifs targeting IL-1. METHODS Five small interfering RNA’s (siRNA) for IL- 1β were chemically generated (Ambion). Chondrocytes cultured in medi um containing lipopolysaccharide (LPS) at 25 μg/mL, to induce IL-1β gene expression, were electroporated with siRNA using a BTX ECM 830 electroporator (Harvard Instruments). After electroporation, cells were plated with 25 μg/mL LPS for another 24 hours. RNA was isolated and real time PCR gene expression analysis performed. The most effective siRNA ribo-oligonucleotide was used as the template to form pSH.IL-1β, a plasmid based short hair-pin coding construct based on the pSIREN shuttle plasmid (Clontech). Following LPS treatment, cells were electroporated with 4ug pSH.IL-1β. IL-1b expression was assessed at 24 hrs postelectroporation. Subsequently, the pSH.IL-1β expression cassette was recombined into the Sleeping Beauty (SB) transposon plasmid upstream of a bicistronic expression/selection cassette derived from pIRESpuro3 (Clontech). Cells were electroporated with an equimolar mix of SB-sh.IL1b and the SB transposase-carrying pCMV-SB plasmid. Ten days post selection (puromycin), genomic integration was confirmed by PCR of genomic DNA for the SBsh.IL1b construct. IL1b expression was assessed in SB-sh.IL1b cells and wild-type cells following 48 hr LPS treatment as described above. Data were analyzed using ANOVA with post-hoc Tukeys classifications. RESULTS Six small interfering RNA’s (siRNA) targeting IL-1β were screened by electroporation into chondrocyte monolayers exposed to LPS. Gene expression for IL-1β and MMP-13 were returned to baseline by several IL-1 silencing ribo-oligonucleotides. Effective siRNA ribo-oligo’s were constructed as plasmid based short hairpin coding constructs to prolong IL-1 knockdown (pSIREN-IL1shRNA). IL-1 shRNA loops, with or without IGF-I gene transduction (bicistronic plasmid expressing IGF-I and IL-1β shRNA), prolonged matrix restorative effects. Chondrocyte monolayers expressing IL-1 shRNA had >60% reduction in IL-1 abundance (Fig 1). Medium from IL -1 shRNA knockdown trials showed consistent IL-1 reduction after shRNA transduction. Effective IL-1 shRNA and IGF-1 coding motifs were developed into Sleeping Beauty plasmid based vectors for transduction of chondrocyte and synoviocyte cultures. Both transgenes were expressed and IL-1 shRNA suppressed IL-1 fluxes in LPS conditioned cultures (Fig 3).
Are depressive symptoms nonspecific in patients with acute stroke?
Authors: J P Fedoroff, S E Starkstein, R M Parikh, T R Price, R G Robinson
Journal: American Journal of Psychiatry (1991)

Some investigators have suggested that major depression might be overdiagnosed in stroke patients because of changes in appetite, sleep, or sexual interest caused by their medical illness; others have suggested that depression may be underdiagnosed in stroke patients who deny symptoms of depression because of anosognosia, neglect, or aprosody. The authors' goal was to determine how frequently depressive symptoms occur in acute stroke patients with and without depressed mood to estimate how often diagnostic errors of inclusion or exclusion may be made.They examined the rate of autonomic and psychological symptoms of depression in 205 patients who were consecutively hospitalized for acute stroke. Eighty-five (41%) of these patients had depressed mood, and 120 (59%) had no mood disturbance. Forty-six (54%) of the 85 patients with depressed mood (22% of all patients) were assigned the DSM-III diagnosis of major depression.The 120 patients without mood disturbance had a mean of one autonomic symptom, but the 85 patients with depressed mood had a mean of almost four. Tightening the diagnostic criteria to account for one more nonspecific autonomic symptom decreased the number of patients with major depression by only three; adding two more criteria decreased the number by only five. Thus, the rate of DSM-III major depression was 1% higher than the rate with one extra nonspecific autonomic symptom and 2% higher than the rate with two extra criteria. Conversely, loosening diagnostic criteria to account for denial of depressive illness increased the rate of major depression by only 5%.Both autonomic and psychological depressive symptoms are strongly associated with depressed mood in acute stroke patients.
A two-photon fluorescent sensor revealing drug-induced liver injury via tracking γ-glutamyltranspeptidase (GGT) level in vivo
Authors: Peisheng Zhang, Xiao-fang Jiang, Xuezheng Nie, Yong Huang, Fang Zeng, Xitao Xia, Shuizhu Wu
Journal: Biomaterials (2015)
Cognitive Impairment: An Independent Predictor of Excess Mortality
Authors: Greg A. Sachs, Ravan Carter, Laura R. Holtz, Faye Smith, Timothy E. Stump, Wanzhu Tu, Christopher M. Callahan
Journal: Annals of Internal Medicine (2011)

Few studies have addressed associations between mild cognitive impairment and mortality. This study used the Short Portable Mental Status Questionnaire to screen for cognitive impairment in patient...