tbuckley/cabot-search huggingface dataset:
Abstract P4-10-11: Nobel Approach for Breast Conserving Surgery after Primary Systemic Therapy: Real-Time Virtual Navigation
Authors: M Suzuki, K Koda, M Yamazaki, T Tezuka, C Kosugi, K Imai, A Hirano, R Nakagawa, K Adachi, R Shirakami, H. Yasuda
Journal: Cancer Research (2010)

Abstract Background: Breast-conserving surgery after primary systemic therapy (PST) has become a widely acceptable procedure for locally advanced breast cancers. Sometimes it is difficult to determine the appropriate resection-line at the time of surgical operation because of tumor size reduction or indistinct boundary of the tumor. Moreover we cannot detect tumors in cases with complete response. That was why we developed a new navigation technique using real-time image reconstruction. Materials and methods: Multi-detector row computed tomography (MD-CT) has been performed for all breast cancer patients in our institute. DICOM images of MD-CT were analyzed by image processing software ‘OsiriX'. OsiriX is an open source software which anyone can download from website (http://www. osirix-viewer.com). OsiriX has been specifically designed for navigation and visualization of multimodality and multidimensional images. We used 3D volume rendering images. At the time of surgery, pre-PST volume rendering images ware superimposed directly on the patients’ skin from projector which was connected to a personal computer in the operating room. Results: We could see ‘real-time’ rendering images (from skin to organ by layer to layer) on the patient's body. By using pre-PST imaging data, we could recognize precise tumor area and could perform breast conserving surgery safer and easier than before. Conclusion: Using 3D reconstruction MD-CT images which were obtained before PST, ‘real-time’ virtual navigation was helpful to determine the resection-line for clear surgical margin in breast-conserving surgery after PST. This new technique does not need some expensive equipments and easily performed by surgeon. Ordinary personal computer and projector make it possible to demonstrate a new environment in surgical operation. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P4-10-11.
Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine.
Authors: R S Williams, R J Lefkowitz
Journal: Circulation Research (1978)

[3H]Dihydroergocryptine ([3H]DHE) binds to sites in membranes derived from rat myocardium that have the characteristics expected of alpha-adrenergic receptors. The binding is saturable with 41 fmol [3H]DHE bound per mg of protein and of high affinity with KD = 2.9 nM. The binding is rapid and readily reversible. Adrenergic agonists compete with [3H]DHE for binding in the order: epinephrine greater than norepinephrine greater than isoproterenol; and adrenergic antagonists compete for binding in the order: phentolamine greater than propranolol. For comparison, (-)[3H]dihydroalprenolol [(-)[3h]dha] was used to bind to sites in the same membrane preparations having characteristics of beta-receptors. The number and affinity of beta-receptors were quite similar to those of the alpha-receptors with 46 fmol (-)[EH]DHA per mg protein bound at saturation and KD = 2.5 nM. These techniques allowed identification of both beta- and alpha-adrenergic receptors in membranes derived from isolated atria, right ventricular free walls, and left ventricles including interventricular septa. This is the first report documenting direct identification of myocardial alpha-receptors by radioligand-binding techniques and complements the literature previously reporting myocardial inotopic and electrophysiological responses to alpha-adrenergic stimulation.
Next Generation Sequencing Reveals Genome Downsizing in Allotetraploid Nicotiana tabacum, Predominantly through the Elimination of Paternally Derived Repetitive DNAs
Authors: S. Renny-Byfield, M. Chester, A. Kovarik, S. C. Le Comber, M.-A. Grandbastien, M. Deloger, R. A. Nichols, J. Macas, P. Novak, M. W. Chase, A. R. Leitch
Journal: Molecular Biology and Evolution (2011)

We used next generation sequencing to characterize and compare the genomes of the recently derived allotetraploid, Nicotiana tabacum (<200,000 years old), with its diploid progenitors, Nicotiana sylvestris (maternal, S-genome donor), and Nicotiana tomentosiformis (paternal, T-genome donor). Analysis of 14,634 repetitive DNA sequences in the genomes of the progenitor species and N. tabacum reveal all major types of retroelements found in angiosperms (genome proportions range between 17–22.5% and 2.3–3.5% for Ty3-gypsy elements and Ty1-copia elements, respectively). The diploid N. sylvestris genome exhibits evidence of recent bursts of sequence amplification and/or homogenization, whereas the genome of N. tomentosiformis lacks this signature and has considerably fewer homogenous repeats. In the derived allotetraploid N. tabacum, there is evidence of genome downsizing and sequences loss across most repeat types. This is particularly evident amongst the Ty3-gypsy retroelements in which all families identified are underrepresented in N. tabacum, as is 35S ribosomal DNA. Analysis of all repetitive DNA sequences indicates the T-genome of N. tabacum has experienced greater sequence loss than the S-genome, revealing preferential loss of paternally derived repetitive DNAs at a genome-wide level. Thus, the three genomes of N. sylvestris, N. tomentosiformis, and N. tabacum have experienced different evolutionary trajectories, with genomes that are dynamic, stable, and downsized, respectively.
A CASE OF FOX-FORDYCE DISEASE
Authors: A. C. ROXBURGH
Journal: British Journal of Dermatology (1943)

Journal Article A CASE OF FOX‐FORDYCE DISEASE Get access A. C. ROXBURGH, M.D., F.R.C.P. A. C. ROXBURGH, M.D., F.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 55, Issue 5, 1 May 1943, Pages 121–124, https://doi.org/10.1111/j.1365-2133.1943.tb10759.x Published: 01 May 1943
Bosentan may induce arthritis flare in patients with scleroderma concomitantly treated with methotrexate
Authors: F Cozzi
Journal: Annals of the Rheumatic Diseases (2006)

In recent years, endothelin receptor antagonism has emerged as an important therapeutic strategy for pulmonary arterial hypertension (PAH). Bosentan, an orally active endothelin receptor antagonist, has proved to be effective in primary PAH or PAH related to connective tissue diseases.1–3

Of 18 patients with PAH related to systemic sclerosis (SSc) treated with bosentan at our division of rheumatology during the past 2 years, two were also affected by rheumatoid-like arthritis before starting bosentan. We here report the clinical course of these two cases.

The first patient, a 55 year old woman, with SSc since 1988, developed a non-erosive polyarthritis affecting the hands, knees, and ankles, with positive rheumatoid factor (RF; 585 U/l) in March 2002. The second patient, a 57 …
GMC suspends doctor for research fraud
Authors: O. Dyer
Journal: BMJ (2003)

A cardiologist who published fraudulent research in the BMJ was last week suspended for a year by the General Medical Council.

Dr Mohammed Naeem Shaukat was found to have altered mortality data to produce results that showed that British patients of Indian origin fared significantly worse than other British patients after first heart attacks. On 1 March 1997 the research was published in the BMJ , in an article …
Epithelial cell proliferation in diverse models of experimental cholelithiasis.
Authors: A J Scott
Journal: Gut (1978)

Proliferation of the epithelial cells of the gall bladder during the initial stages of experimental cholelithiasis has been studied by autoradiography. Rabbits taking a diet with 1% dihydrocholesterol added showed a rise in labelling index from 1.5%-19% by three days. Mice taking a 1% cholesterol 0.5% cholic acid diet showed a similar rise from less than 1% to 15-21% at two and five days. Guinea-pigs receiving lincomycin showed a rise from less than 1% to 6% after 24 hours. These changes, which appear well before the appearance of gall stones, together with previous reports of enhanced mucous secretion during lithogenesis, make it clear that in these laboratory models of cholelithiasis the gall bladder is abnormal well before stones form.
Androgen-Dependent Regulation of Her-2/neu in Prostate Cancer Cells
Authors: Raanan Berger, Douglas I. Lin, Maria Nieto, Ewa Sicinska, Levi A. Garraway, Heiner Adams, Sabina Signoretti, William C. Hahn, Massimo Loda
Journal: Cancer Research (2006)

Abstract The mechanisms underlying the progression of prostate cancer to a state of resistance to hormone ablation remain poorly understood. Here, we have investigated the relationship between androgen receptor (AR) and Her-2/neu in prostate cancer cells. Overexpression of Her-2/neu (c-ErbB2) activates the AR pathway and confers a survival and growth advantage to prostate cancer cells in an androgen-deficient milieu. In vitro, the absence of androgens or AR blockade induced Her-2/neu protein expression and phosphorylation. In contrast, upon readministration of androgens, Her-2/neu mRNA, protein, and phosphorylation levels decreased linearly with increasing concentrations of dihydrotestosterone as LNCaP cells reentered the cell cycle. In vivo, induction of Her-2/neu by castration in orthotopically injected LNCaP cells resulted in a progressive increase in prostate-specific antigen secretion into the mouse serum, indicating that Her-2/neu-mediated, AR-dependent transcription occurs following castration and results in tumor cell growth. Finally, selection of LNCaP cells stably transfected with short hairpin RNA specific for AR resulted in Her-2/neu overexpression. Similarly, knockdown of Her-2/neu led to induction of AR. However, when Her-2/neu and AR were simultaneously targeted, we observed cell death, whereas surviving cells retained low level expression of Her-2/neu. Thus, induction and activation of Her-2/neu occurs in an androgen-depleted environment or as a result of AR inactivation, promoting ablation-resistant survival of prostate cancer cells. These data provide the biochemical rationale to target Her-2/neu in hormone-refractory prostate cancer. (Cancer Res 2006; 66(11): 5723-8)
Coronary venular responses to flow and pressure.
Authors: L Kuo, F Arko, W M Chilian, M J Davis
Journal: Circulation Research (1993)

In previous studies, we demonstrated that both endothelium-dependent flow-induced vasodilation and endothelium-independent myogenic responses occur in porcine coronary arterioles. However, it was not established whether these responses are present in the coronary venular microcirculation. The aim of this study was to test the hypotheses that 1) coronary venules, like arterioles, exhibit flow-induced dilation and myogenic responsiveness, and 2) venular flow-induced dilation is endothelium-dependent and is mediated by the release of a nitrovasodilator. Experiments were performed in porcine subepicardial coronary venules, 80-120 microns in diameter, by using cannulated isolated vessel techniques to allow intraluminal pressure and flow to be independently controlled. Flow was initiated by simultaneously moving two perfusion reservoirs connected to the cannulating pipettes in equal amounts but in opposite directions. In the absence of flow, i.e., zero pressure gradient (delta P) between the two reservoirs, venules developed spontaneous tone to 75-80% of maximum diameter at 10 cm H2O intraluminal pressure. Venules gradually dilated in response to stepwise increases in flow (i.e., delta P). The threshold for the flow-induced dilation occurred at delta P = 1 cm H2O (flow = 3.5 nl/sec), and the maximal response (dilation to 93 +/- 2% of maximum diameter) occurred when delta P was elevated to > or = 6 cm H2O (flow = 21 nl/sec at delta P = 6 cm H2O). Flow-induced dilation was abolished after the endothelium was damaged by perfusion of an air bolus through the lumen. Vasoconstriction was observed when denuded venules were subjected to relatively high luminal flows (> or = 21 nl/sec).(ABSTRACT TRUNCATED AT 250 WORDS)
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
Authors: Edward W. Roberts, Andrew Deonarine, James O. Jones, Alice E. Denton, Christine Feig, Scott K. Lyons, Marion Espeli, Matthew Kraman, Brendan McKenna, Richard J.B. Wells, Qi Zhao, Otavia L. Caballero, Rachel Larder, Anthony P. Coll, Stephen O’Rahilly, Kevin M. Brindle, Sarah A. Teichmann, David A. Tuveson, Douglas T. Fearon
Journal: The Journal of Experimental Medicine (2013)

Fibroblast activation protein-α (FAP) identifies stromal cells of mesenchymal origin in human cancers and chronic inflammatory lesions. In mouse models of cancer, they have been shown to be immune suppressive, but studies of their occurrence and function in normal tissues have been limited. With a transgenic mouse line permitting the bioluminescent imaging of FAP+ cells, we find that they reside in most tissues of the adult mouse. FAP+ cells from three sites, skeletal muscle, adipose tissue, and pancreas, have highly similar transcriptomes, suggesting a shared lineage. FAP+ cells of skeletal muscle are the major local source of follistatin, and in bone marrow they express Cxcl12 and KitL. Experimental ablation of these cells causes loss of muscle mass and a reduction of B-lymphopoiesis and erythropoiesis, revealing their essential functions in maintaining normal muscle mass and hematopoiesis, respectively. Remarkably, these cells are altered at these sites in transplantable and spontaneous mouse models of cancer-induced cachexia and anemia. Thus, the FAP+ stromal cell may have roles in two adverse consequences of cancer: their acquisition by tumors may cause failure of immunosurveillance, and their alteration in normal tissues contributes to the paraneoplastic syndromes of cachexia and anemia.
FATALITIES RESULTING FROM TREATMENT WITH SUBSHOCK DOSES OF INSULIN
Authors: N. MALAMUD
Journal: American Journal of Psychiatry (1948)

1. Fatalities resulting from the use of small doses of insulin are described in (a) subshock treatment of a case of schizophrenia and in (b) tonic treatment of a case of delirium tremens. 2. The clinical and pathoanatomic features in these two cases are identical with those observed in fatal complications of ordinary insulin shock therapy.
Imprecise color constancy versus color realism
Authors: Brian V. Funt
Journal: Behavioral and Brain Sciences (2003)

Abstract Byrne &amp; Hilbert's thesis, that color be associated with reflectance-type, is questioned on the grounds that it is far from clear that the human visual system is able to determine a surface's reflectance-type with sufficient accuracy. In addition, a (friendly) suggestion is made as to how to amend the definition of reflectance-type in terms of CIE (Commission Internationale de l'Eclairage) coordinates under a canonical illuminant.
Molecular epidemiology of a clonal outbreak of multidrug-resistant Acinetobacter baumannii in a university hospital in Italy
Authors: R. Zarrilli, R. Casillo, A. Di Popolo, M.-F. Tripodi, M. Bagattini, S. Cuccurullo, V. Crivaro, E. Ragone, A. Mattei, N. Galdieri, M. Triassi, R. Utili
Journal: Clinical Microbiology and Infection (2007)
Late postnatal mother-to-child transmission of HIV-1 in Abidjan, Côte d'lvoire
Authors: Ehounou R Ekpini, Stefan Z Wiktor, Glen A Satten, Georgette T Adjorlolo-Johnson, Toussaint S Sibailly, Chin-Yih Ou, John M Karon, Kari Brattegaard, J Patrick Whitaker, Emmanuel Gnaore, Kevin M De Cock, Alan E Greenberg
Journal: The Lancet (1997)
Bilateral isokinetic variables of the shoulder: a prediction model for young men.
Authors: R C So, O T Siu, M K Chin, K M Chan
Journal: British Journal of Sports Medicine (1995)

Clinicians frequently want to know the pre-injury strength of an uninjured limb. The purpose of this study was to delineate the differences in bilateral isokinetic peak torque (PT) at 60 degrees and 240 degrees, and torque acceleration energy (TAE), average power (AP) and total work (TW) at 240 degrees during shoulder extension and flexion movements, and to develop a method to determine the expected maximal isokinetic variables of the dominant shoulder based upon isokinetic measurements from the non-dominant shoulder. Shoulder isokinetic measurements were obtained from 30 normal young male adults. While bilateral correlation was significant (P < 0.01), results also suggest significant bilateral differences P < 0.01). Thus, it is inappropriate to use the uninjured extremity to predict the pre-injured strength of the injured side without adjustment. In this investigation models were developed relating the expected maximal isokinetic measurement of the dominant shoulder to the non-dominant shoulder measurements.
Capture of Type 1 Diabetes–Susceptible HLA DR-DQ Haplotypes in Japanese Subjects Using a Tag Single Nucleotide Polymorphism
Authors: Koji Nakanishi, Yukio Shima
Journal: Diabetes Care (2009)

To identify type 1 diabetes-susceptible HLA DR-DQ haplotypes using tag single nucleotide polymorphisms (SNPs) and to estimate the disease risk using these tag SNPs.Five tag SNPs were typed in a total of 211 Japanese subjects including 201 patients with type 1 diabetes who had already been typed for HLA-DRB1, -DQA1, and -DQB1 alleles and 300 control subjects.Tag SNP rs2395185 captured haplotypes involving all DR4 specificities and DR9 specificity with a sensitivity of 98.5% and specificity of 94.9%. Using the T allele of rs2395185, we obtained an odds ratio (95% CI) of 2.87 (2.21-3.74) for type 1 diabetes. In addition, rs3129888 captured haplotypes involving HLA-DRB1*0802 with a sensitivity of 92.3% and specificity of 98.9%.Typing of two tag SNPs (rs2395185 and rs3129888) may be useful for the screening of Japanese subjects at genetic risk of type 1 diabetes.
Metabolic syndrome, insulin resistance and sleepiness in real-life obstructive sleep apnoea
Authors: Maria R Bonsignore, Cristina Esquinas, Antonia Barceló, Manuel Sanchez-de-la-Torre, Alessandra Paternó, Joaquin Duran-Cantolla, José M Marín, Ferran Barbé
Journal: European Respiratory Journal (2011)

The metabolic syndrome shows a variable prevalence in obstructive sleep apnoea (OSA), and its association with insulin resistance or excessive daytime sleepiness in OSA is unclear. This study assessed the following in consecutive patients with newly diagnosed OSA: 1) the prevalence of metabolic syndrome; and 2) its association with insulin resistance and daytime sleepiness. Metabolic syndrome (National Cholesterol Education Program Adult Treatment Panel (NCEP-ATP) III criteria), insulin resistance (Homeostatic Model Assessment (HOMA) index, n=288) and daytime sleepiness (Epworth Sleepiness Scale) were assessed in 529 OSA patients. The prevalence of metabolic syndrome was 51.2%, which increased with OSA severity. Each metabolic syndrome component correlated with apnoea/hypopnoea index, but only blood pressure retained significance after correction for confounders. Both obesity and OSA contributed to metabolic abnormalities, with different sex-related patterns, since diagnosis of metabolic syndrome was significantly associated with neck circumference, age, body mass index and lowest arterial oxygen saturation in males, and with age and arousal index in females. The number of metabolic syndrome components increased with HOMA index (p&lt;0.001). Prevalence of sleepiness was the same in patients with and without metabolic syndrome. The metabolic syndrome occurs in about half of "real-life" OSA patients, irrespective of daytime sleepiness, and is a reliable marker of insulin resistance.
Progressive supravenous granulomatous nodular eruption in a human immunodeficiency virus-positive intravenous drug user treated with highly active antiretroviral therapy
Authors: A. Fernández-Casado, G. Martin-Ezquerra, M. Yébenes, F. Plana, J.J. Elvira-Betanzos, J.E. Herrero-González, M.L. Mariñoso, R.M. Pujol
Journal: British Journal of Dermatology (2007)

Journal Article Progressive supravenous granulomatous nodular eruption in a human immunodeficiency virus‐positive intravenous drug user treated with highly active antiretroviral therapy Get access A. Fernández‐Casado, A. Fernández‐Casado Departments of Dermatology and Pathology, Hospital del Mar‐IMAS, Passeig Marítim 25–29, 08003 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar G. Martin‐Ezquerra, G. Martin‐Ezquerra Departments of Dermatology and Pathology, Hospital del Mar‐IMAS, Passeig Marítim 25–29, 08003 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar M. Yébenes, M. Yébenes Departments of Dermatology and Pathology, Hospital del Mar‐IMAS, Passeig Marítim 25–29, 08003 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar F. Plana, F. Plana Institut de Ciències de la Terra 'Jaume Almera', CSIC, Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar J.J. Elvira‐Betanzos, J.J. Elvira‐Betanzos Institut de Ciències de la Terra 'Jaume Almera', CSIC, Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar J.E. Herrero‐González, J.E. Herrero‐González Departments of Dermatology and Pathology, Hospital del Mar‐IMAS, Passeig Marítim 25–29, 08003 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar M.L. Mariñoso, M.L. Mariñoso Departments of Dermatology and Pathology, Hospital del Mar‐IMAS, Passeig Marítim 25–29, 08003 Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar R.M. Pujol R.M. Pujol Departments of Dermatology and Pathology, Hospital del Mar‐IMAS, Passeig Marítim 25–29, 08003 Barcelona, Spain Correspondence: Ramon M. Pujol. E‐mail: rpujol@imas.imim.es Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 1, 1 January 2008, Pages 145–149, https://doi.org/10.1111/j.1365-2133.2007.08238.x Published: 01 January 2008
Incidence of Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Embolism
Authors: Vittorio Pengo, Anthonie W.A. Lensing, Martin H. Prins, Antonio Marchiori, Bruce L. Davidson, Francesca Tiozzo, Paolo Albanese, Alessandra Biasiolo, Cinzia Pegoraro, Sabino Iliceto, Paolo Prandoni
Journal: New England Journal of Medicine (2004)

Chronic thromboembolic pulmonary hypertension (CTPH) is associated with considerable morbidity and mortality. Its incidence after pulmonary embolism and associated risk factors are not well documented.We conducted a prospective, long-term, follow-up study to assess the incidence of symptomatic CTPH in consecutive patients with an acute episode of pulmonary embolism but without prior venous thromboembolism. Patients with unexplained persistent dyspnea during follow-up underwent transthoracic echocardiography and, if supportive findings were present, ventilation-perfusion lung scanning and pulmonary angiography. CTPH was considered to be present if systolic and mean pulmonary-artery pressures exceeded 40 mm Hg and 25 mm Hg, respectively; pulmonary-capillary wedge pressure was normal; and there was angiographic evidence of disease.The cumulative incidence of symptomatic CTPH was 1.0 percent (95 percent confidence interval, 0.0 to 2.4) at six months, 3.1 percent (95 percent confidence interval, 0.7 to 5.5) at one year, and 3.8 percent (95 percent confidence interval, 1.1 to 6.5) at two years. No cases occurred after two years among the patients with more than two years of follow-up data. The following increased the risk of CTPH: a previous pulmonary embolism (odds ratio, 19.0), younger age (odds ratio, 1.79 per decade), a larger perfusion defect (odds ratio, 2.22 per decile decrement in perfusion), and idiopathic pulmonary embolism at presentation (odds ratio, 5.70).CTPH is a relatively common, serious complication of pulmonary embolism. Diagnostic and therapeutic strategies for the early identification and prevention of CTPH are needed.