tbuckley/cabot-search huggingface dataset:
Triad of post-ERCP pancreatitis, and gastric outlet, and biliary obstruction: are we dealing with intramural duodenal hematoma?
Authors: Ragesh Thandassery, Anil John, Renol Koshy, Saad Kaabi
Journal: Endoscopy (2014)

A 20-year-old woman who was being followed up for previous laparoscopic cholecystectomy for symptomatic cholelithiasis underwent endoscopic retrograde cholangiopancreatography (ERCP)-sphincterotomy and extraction of a retained common bile duct (CBD) stone (measuring 6 mm). Following ERCP, she developed progressive increase in liver function values, mild abdominal pain, and persistent bilious vomiting. She also had mild elevation in pancreatic enzyme levels. Abdominal radiograph ruled out bowel perforation.
Surveillance of Health Care Workers Exposed to Blood from Patients Infected with the Human Immunodeficiency Virus
Authors: Ruthanne Marcus
Journal: New England Journal of Medicine (1988)

Since 1983, we have conducted national surveillance of health care workers exposed to blood or body fluids from persons infected with the human immunodeficiency virus (HIV), to assess the risk of HIV transmission by such exposures. As of July 31, 1988, 1201 health care workers with blood exposures had been examined, including 751 nurses (63 percent), 164 physicians and medical students (14 percent), 134 laboratory workers (11 percent), and 90 phlebotomists (7 percent). The exposures resulted from needle-stick injuries (80 percent), cuts with sharp objects (8 percent), open-wound contamination (7 percent), and mucous-membrane exposure (5 percent). We concluded that 37 percent of the exposures might have been prevented. Of 963 health care workers whose serum has been tested for HIV antibody at least 180 days after exposure, 4 were positive, yielding a seroprevalence rate of 0.42 percent (upper limit of 95 percent confidence interval, 0.95 percent). Three subjects experienced an acute retroviral syndrome associated with documented seroconversion; serum collected within 30 days of exposure was not available from the fourth person. Two exposures that resulted in seroconversion were caused by coworkers during resuscitation procedures. We conclude that the risk of HIV infection after exposure to the blood of a patient infected with HIV is low, but at least six months of follow-up is recommended. Many exposures can be prevented by careful adherence to existing infection-control precautions, even during emergencies. (N Engl J Med 1988; 319:1118–23.)
A Case of Iodine-131 Retention in the Esophagus Mimicking a Mediastinal Metastasis in a Patient With Follicular Thyroid Carcinoma After Gastric Volume Reduction Operation
Authors: Malgorzata Knapska-Kucharska, Jacek Makarewicz
Journal: Clinical Nuclear Medicine (2011)

Whole-body I-131 scintigraphy (I-131-WBS) is a standard follow-up procedure in patients treated for differentiated thyroid carcinoma. Although uptake of I-131 is relatively specific, there are reports of false-positive accumulation of radioiodine. We present a patient with cervical and mediastinal activity detected on I-131-WBS 18 years after primary therapy for follicular thyroid carcinoma and 1 year after laparoscopic adjustable gastric banding for obesity. After further evaluation, the activity was diagnosed as radioiodine retained in dilated esophagus. Although esophageal retention of I-131 is a relatively frequent cause of false-positive I-131-WBS, gastroesophageal outlet stricture is an uncommon complication of laparoscopic adjustable gastric banding.
Mammography utilization in women age 40 to 49: The French EDIFICE survey.
Authors: F. Eisinger, X. B. Pivot, J. Blay, Y. Coscas, J. Viguier, A. Calazel Benque, C. Roussel, J. F. Morere
Journal: Journal of Clinical Oncology (2010)

1571 Background: Mammography screening for women in their forties with standard risk is controversial; the recent update from the USPSTF highlights again the issue raised in 1997 by S. Fletcher (Alice in the wonderland of breast cancer screening). Notwithstanding the pro and cons or scientific data and modeling, women's behaviors might enlighten the debate. In France, there is no personal cost for breast cancer screening using mammography, although there are no official recommendations for women in their forties. Thus, the woman's choice should reflect her own preferences without economic bias. Methods: We analyzed French data from the 2008 survey of the EDIFICE program, which is an iterative national health survey based on telephone interviews.. This nationwide observational study was carried out in France among a representative sample of subjects aged between 40 and 75 years. Results: In France 78.0% of the 40-49 year-old women interviewed declared having undergone at least one mammogram (66.1% and 87.5% for the 40-44 y and 45-49 y age groups respectively). For a mammogram within the last 2 years, the figure is 63.0% (51.9% and 71.8% respectively). In 2006 in the USA, 69.6% of women aged 40-49 y had undergone a mammogram within the past 2 years according to the Behavioral Risk Factor Surveillance System (Ryerson et al). In women under 50y who had undergone a mammogram: the mean number of tests was 3.2, the mean age at first mammography was 37.1y (SD: 7.0). The reason for the first mammogram was symptom management 23%; familial history 14%; and medical advice 58%, including advice from GP 12% and gynaecologist 45%. Logistic regression explicative factors (never had mammogram versus had at least one mammogram). (1) Age 45-49 y vs. 40-44y: OR = 10.0 (3.8-25.0); (2) Local program for CCR screening: OR = 4.17 (1.21-14.40); (3) Awareness of the recommended screening period (2y): OR = 3.69 (1.5- 9.05); (4) Previous (less than 1 y) consultation with a gynecologist: OR = 3.28 (1.32-8.14). Conclusions: Notwithstanding the debate on the risk/benefit of breast cancer screening for women in their forties, we observed for attendance a much bigger difference between women aged 40-45 y vs. 46-74 y rather than between women aged 40-49 y vs. 50-74 y (the official age-range). No significant financial relationships to disclose.
P653Efficacy of remote ischaemic preconditioning in diabetic rats
Authors: I Harding, RM Bell, DM Yellon
Journal: Cardiovascular Research (2014)

Purpose: The diabetic myocardium paradoxically displays not only greater resistance to ischaemia/reperfusion injury (IRI) but also decreased sensitivity to cytoprotection by either pharmacological or ischaemic conditioning. Remote ischaemic preconditioning (RIPC), through induction of transient non-injurious ischaemia in a distant organ or tissue, triggers significant protection against myocardial IRI in healthy subjects, but its efficacy in the diabetic is unknown.
Prevalence, Incidence and Persistence of EB Virus Antibody in Young Adults
Authors: J. C. Niederman, A. S. Evans, L. Subrahmanyan, R. W. McCollum
Journal: New England Journal of Medicine (1970)

The prevalence rate for antibody to EB virus measured by the indirect immunofluorescence technic in 1084 young adults varied from 26 to 87 per cent depending on age and geographic area. In a prospective study of 150 Yale students 53 had EBV antibody on entry into college; 43 of 97 students lacking antibody had seroconversion during the next four to eight years, 28 with recognized clinical infectious mononucleosis and 15 with inapparent or unrecognized illness. This was an infection rate of 11.1 per cent per year in the susceptible group. Of 164 Peace Corps volunteers 76 per cent had detectable anti-EBV titers on entrance into service, and of 30 lacking antibody 27 per cent were infected over one year while working in Colombia, South America. In Yale students EBV antibody was always present in serum specimens obtained as long as eight years after clinical or subclinical infection, usually at levels of 1:40 or higher.
A NOVEL METHOD FOR ASSESSING INFLAMMATION IN ASCENDING AORTA BY F-18FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY IMAGING IS HIGHLY REPRODUCIBLE
Authors: Richard Weinberg, Mona Kinkhabwala, Demetrios Panagiotou, Ayse Bag-Ozbek, Zhezhen Jin, Andrew Einstein, Joan Bathon, Sabahat Bokhari
Journal: Journal of the American College of Cardiology (2015)
Abstract 198: TRAF2 phosphorylation is essential for cancer-cell adaptation to chronic cellular stress
Authors: Hasem Habelhah, Ken Blackwell, Laiqun Zhang
Journal: Cancer Research (2011)

Abstract The tumor microenvironment is known to trigger chronic endoplasmic reticulum (ER) and oxidative stresses, and cancer-cell adaptation to such chronic stresses has profound consequences for malignant progression and the response to therapy. TRAF2 regulates cellular response to TNFα, ER and oxidative stresses by activating the JNK/c-Jun and IKK/NF-κB signaling cascades. We mapped two phosphorylation sites (Ser-11 and Ser-55) on the N-terminal RING domain of TRAF2, and reported that phosphorylation at these sites increases basal and TNFα-induced NF-κB activation. Recently, we identified TBK1 and PKCζ as the kinases that directly phosphorylate TRAF2 at Ser-11 and Ser-55 sites, respectively. We found that in addition to TNFα, ER and oxidative stresses also strongly induce TRAF2 phosphorylation at both sites. This dual phosphorylation of TRAF2 promoted IKK activation and inhibited the prolonged phase of JNK activation in response to ER and oxidative stresses. Importantly, TRAF2 phosphorylation was found to be essential for cancer-cell survival under conditions of chronic cellular stress. Specifically, the endogenous TRAF2-dockdown cancer cells that were stable expressed with phospho-null-mutant TRAF2 (TRAF2-S11/55A) did not survive under conditions of chronic ER and oxidative stresses, while their TRAF2-WT counterparts survived under the same conditions. In addition, the TRAF2-S11/55A-expressing cancer cells formed significantly smaller tumors in vivo and exhibited greater sensitivity to anti-cancer drug-induced apoptosis than did TRAF2-WT-expressing counterparts. Functional assays revealed that TRAF2 phosphorylation not only promotes NF-κB-dependent gene expression, but also suppresses JNK-mediated degradation of Bcl-2 and cIAP1 at post-transcriptional level in the context of ER and oxidative stresses. Collectively, these findings suggest that TRAF2 phosphorylation plays a critical role in tumor progression by promoting the expression of anti-apoptotic proteins in cancer cells, and could be a new target for anti-cancer drug development. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 198. doi:10.1158/1538-7445.AM2011-198
Argon plasma coagulation of a bleeding angioectasia in a jejunal diverticulum by single-balloon enteroscopy
Authors: Carlos Fernandes, Rolando Pinho, Adélia Rodrigues, Germano Vilas-Boas, Iolanda Ribeiro, Joana Silva, Ana Ponte, João Carvalho
Journal: Endoscopy (2015)

An 86-year-old woman with a history of cardiac and chronic renal failure was referred to our gastroenterology outpatient clinic because of an iron deficiency anemia and intermittent, self-limited hematochezia episodes. Colonoscopy and upper endoscopy revealed no alterations. A capsule endoscopy showed a nonbleeding angioectasia in the proximal ileum. Single-balloon enteroscopy was proposed to treat the angioectasia. During the procedure, a large jejunal diverticulum with a bulky clot was seen in the proximal jejunum ([Fig. 1]). The clot was removed after water irrigation, and an oozing bleeding was found from an angioectasia located in the fundus of the diverticulum ([Fig. 2]). Distal tattooing was performed. Bleeding was then controlled with combination therapy: first a submucosal epinephrine injection ([Fig. 3]) followed by argon plasma coagulation (APC) of the angioectasia ([Fig. 4]). No immediate or delayed complications were recorded, and there was no recurrence of bleeding during 1 year of follow-up.
Stat Bite: Cancer Mortality in Alaska Native Women
Authors: L. Burhansstipanov
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Stat Bite : Cancer Mortality in Alaska Native Women Get access Linda Burhansstipanov, Dr., Ph.D Linda Burhansstipanov, Dr., Ph.D Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 16, August 1993, Page 1273, https://doi.org/10.1093/jnci/85.16.1273 Published: 01 August 1993
Telemedicine: Scanning the Future of Cancer Control
Authors: L. Fintor
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Telemedicine: Scanning the Future of Cancer Control Get access Lou Fintor Lou Fintor Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 3, 3 February 1993, Pages 183–184, https://doi.org/10.1093/jnci/85.3.183 Published: 03 February 1993
Value of high-frequency miniprobes and conventional radial endoscopic ultrasound in the staging of early Barrett's carcinoma
Authors: O. Pech, E. Günter, F. Dusemund, C. Ell
Journal: Endoscopy (2010)

See also: Commentaire de travail de O. Pech et al., pp. 98Endoscopy 2010; 42(02): 184-184DOI: 10.1055/s-0031-1291837
Tips for a Physician in Getting the Right Job, Part II
Authors: Jay A. Harolds
Journal: Clinical Nuclear Medicine (2013)

It is very important that a job seeker prepares an excellent curriculum vitae (CV) and cover letter. Often a personal statement is also needed. If these are not done well, often an interview is not granted. There are different formats and headings for the CV, depending on the type of job sought and the institution the job is located in. There are also some differences in how this is done between different countries. However, there are also many common elements of a proper CV.
Angiomatoid Fibrous Histiocytoma
Authors: William Makis, Anthony Ciarallo, Marc Hickeson, Vilma Derbekyan
Journal: Clinical Nuclear Medicine (2011)

Angiomatoid fibrous histiocytoma is a very rare tumor that accounts for 0.3% of all soft-tissue tumors, and occurs predominantly in the extremities of adolescents and young adults. It has been classified by the World Health Organization as a tumor of uncertain differentiation with intermediate malignant potential, although recent evidence suggests a myoid or myofibroblastic cell origin. Most examples behave in an indolent manner with a regional recurrence rate of 15% and a rate of metastasis of 1%. We present a 29-year-old woman who was referred for an F-18 FDG PET/CT to evaluate a left shoulder mass. She had multiple local FDG-avid lymph nodes, and initial biopsy was suggestive of epithelioid sarcoma. She was treated with chemotherapy, but a post-therapy PET/CT showed minimal response and radical surgical excision was performed. The histopathology and immunohistochemistry was consistent with angiomatoid fibrous histiocytoma. This case highlights a potential new utility for F-18 FDG PET/CT in the staging and evaluation of response to therapy for this very rare soft-tissue tumor.
1349 ELEVATED OSTEOPONTIN EXPRESSION IN LIVER, ADIPOSE TISSUE AND SERUM IS CORRELATED WITH FIBROSIS IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
Authors: S. Patouraux, S. Bonnafous, C.S. Voican, R. Anty, M.-C. Saint-Paul, M.-A. Rosenthal-Allieri, H. Agostini, M. Njike, N. Barri-Ova, S. Naveau, Y. Le Marchand-Brustel, P. Cales, G. Perlemuter, A. Tran, P. Gual
Journal: Journal of Hepatology (2012)
Unusual Excretion of Tc-99m MDP in Regional Intestinal Lymphangiectasia
Authors: FLAVIO ZELMANOVITZ, PAULO RICARDO MASIERO, BERNARDO LEÃO SPIRO
Journal: Clinical Nuclear Medicine (2003)

ZELMANOVITZ, FLAVIO M.D.; RICARDO MASIERO, PAULO M.D.; LEÃO SPIRO, BERNARDO M.D. Author Information
Treatment and Prophylaxis of<i>Isospora belli</i>Infection in Patients with the Acquired Immunodeficiency Syndrome
Authors: Jean W. Pape, Rose-Irene Verdier, Warren D. Johnson
Journal: New England Journal of Medicine (1989)

Enteric infection with the protozoan Isospora belli is common in patients with the acquired immunodeficiency syndrome (AIDS) and causes severe diarrhea. I. belli responds well to treatment with trimethoprim–sulfamethoxazole, but there is a high rate of recurrence. To investigate the effect of long-term prophylaxis, we studied 32 Haitian patients with AIDS complicated by I. belli infection and chronic diarrhea. All were treated with trimethoprim (160 mg) and sulfamethoxazole (800 mg), given orally four times a day for 10 days; the patients were then randomly assigned to receive 500 mg of sulfadoxine and 25 mg of pyrimethamine weekly, 160 mg of trimethoprim and 800 mg of sulfamethoxazole three times a week, or placebo. Half of the patients (5 of 10) who received placebo had recurrent, symptomatic isosporiasis a mean of 1.6 months after the initial treatment. All 22 patients who received either trimethoprim–sulfamethoxazole or sulfadoxine–pyrimethamine remained asymptomatic. I. belli was identified in the stools of only one of these patients, who was receiving trimethoprim–sulfamethoxazole. The study medications were generally well tolerated but had to be discontinued in the cases of two patients because of severe pruritus. In 10 patients, the prophylactic regimen has been continued for a mean of 16 months without recurrent isosporiasis. We conclude that isosporiasis in patients with AIDS can be treated effectively with a 10-day course of trimethoprim–sulfamethoxazole and that recurrent disease can subsequently be prevented by ongoing prophylaxis with either trimethoprim–sulfamethoxazole or sulfadoxine–pyrimethamine. (N Engl J Med 1989; 320:1044–7.)
The Pathogenesis of Bronchiectasis
Authors: Tracy B. Mallory
Journal: New England Journal of Medicine (1947)

SINCE Laennec1 first described and named bronchiectasis its etiology and mode of development have been controversial issues. Numerous theories have been advanced, each of which is backed by voluminous evidence, but no one of which satisfactorily explains all types or features of the disease. Either the underlying cause remains undiscovered or multiple factors exist that predispose to or result in dilatation of portions of the bronchial tree. I propose, in the short time at my disposal, to review briefly the more significant of these possible factors and to compare their relative importance and interrelation.Four important clinical and anatomic features . . .
Abstract 598: EMT and nectin-1 mediate sensitivity to HSV-1 oncolysis in human HCC cell lines
Authors: Bryan C. Fuchs, Toshihiko Kuroda, Suguru Yamada, Christopher M. McGinn, Anthony Schmitt, Michael Lanuti, Kenneth K. Tanabe
Journal: Cancer Research (2010)

Abstract Background: Oncolytic viral therapy mediated by herpes simplex virus 1 (HSV-1) is an emerging and promising cancer therapy. The entry of HSV-1 into cells is mediated in part by cell surface co-receptors. One of these co-receptors, nectin-1, is highly expressed in epithelial cells. Nectin-1 is localized to adherens junctions (AJs) where it interacts with E-cadherin through their respective peripheral membrane proteins, afadin and catenin. The loss of E-cadherin is a hallmark of epithelial-to-mesenchymal transition (EMT) and results in the disassembly of AJs. Here, we investigate the effects of EMT on cell surface nectin-1 expression, HSV infection and viral oncolysis. Methods: Western blot analysis was performed to determine E-cadherin expression in human HCC cell lines. Cytotoxicity to HSV-1 KOS strain was assessed by MTT analysis. KOS replication was assessed by a single-step burst assay, while viral infectivity was examined using the mutant bM24-BAC#3 virus which encodes GFP. Cell surface levels of nectin-1 and herpesvirus entry mediator (HVEM) were determined by flow cytometry and the role of nectin-1 in HSV-1 infectivity was further assessed using a nectin-1 neutralizing antibody. Results: Four of the human HCC cell lines were epithelial and four were mesenchymal. KOS oncolysis resulted in 50% cell death in the epithelial cell lines at multiplicities of infection (MOIs) 2-3 log orders less than the mesenchymal HCC cell lines. This difference was not attributed to cell growth rates as determined by population doubling times or to viral replication as assessed by burst assay. Instead, the epithelial cell lines had higher rates of infectivity which were attributed to greater cell surface expression of nectin-1 and not HVEM. Finally, blocking of nectin-1 with a neutralizing antibody inhibited viral oncolysis in all four epithelial HCC cell lines. Conclusions: EMT in human HCC cells results in the loss of nectin-1 cell surface expression and resistance to HSV-1 oncolysis. E-cadherin and nectin-1 are markers of sensitivity to HSV-1 oncolysis in human HCC cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 598.
Contributory Role of Extrarenal Factors in the Polyuria of Potassium Depletion
Authors: Charles R. Kleeman, Morton H. Maxwell
Journal: New England Journal of Medicine (1959)

THE multiple structural and functional effects of potassium depletion on the kidney (Table 1) are becoming increasingly evident.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 The most prominent and consistent symptom of potassiumdepletion nephropathy is polyuria, attributable in large part to failure of the renal tubule to respond to endogenous antidiuretic hormone or exogenous vasopressin administration. It has recently been suggested15 , 16 that the polyuria and associated polydipsia may be due in part to an extrarenal alteration of water metabolism.The present paper is concerned with studies on a patient with chronic potassium depletion in whom a demonstrable extrarenal disturbance of water metabolism contributed significantly to the polyuric . . .