tbuckley/cabot-search huggingface dataset:
High T-cadherin expression is a feature of basal cell carcinoma
Authors: S.A. Buechner, M. Philippova, P. Erne, T. Mathys, T.J. Resink
Journal: British Journal of Dermatology (2009)

Journal Article High T‐cadherin expression is a feature of basal cell carcinoma Get access S.A. Buechner, S.A. Buechner Blumenrain 20, CH 4051 Basel, Switzerland *Department of Biomedicine, Laboratory for Signal Transduction, Basel University Hospital, CH 4031 Basel, Switzerland †Division of Cardiology, Kantonsspital Luzern, CH 6000 Luzern, Switzerland Search for other works by this author on: Oxford Academic Google Scholar M. Philippova, M. Philippova Blumenrain 20, CH 4051 Basel, Switzerland *Department of Biomedicine, Laboratory for Signal Transduction, Basel University Hospital, CH 4031 Basel, Switzerland †Division of Cardiology, Kantonsspital Luzern, CH 6000 Luzern, Switzerland Search for other works by this author on: Oxford Academic Google Scholar P. Erne, P. Erne Blumenrain 20, CH 4051 Basel, Switzerland *Department of Biomedicine, Laboratory for Signal Transduction, Basel University Hospital, CH 4031 Basel, Switzerland †Division of Cardiology, Kantonsspital Luzern, CH 6000 Luzern, Switzerland Search for other works by this author on: Oxford Academic Google Scholar T. Mathys, T. Mathys Blumenrain 20, CH 4051 Basel, Switzerland *Department of Biomedicine, Laboratory for Signal Transduction, Basel University Hospital, CH 4031 Basel, Switzerland †Division of Cardiology, Kantonsspital Luzern, CH 6000 Luzern, Switzerland Search for other works by this author on: Oxford Academic Google Scholar T.J. Resink T.J. Resink Blumenrain 20, CH 4051 Basel, Switzerland *Department of Biomedicine, Laboratory for Signal Transduction, Basel University Hospital, CH 4031 Basel, Switzerland †Division of Cardiology, Kantonsspital Luzern, CH 6000 Luzern, Switzerland Correspondence: Therese Resink. E‐mail: Therese‐J.Resink@unibas.ch Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 161, Issue 1, 1 July 2009, Pages 199–202, https://doi.org/10.1111/j.1365-2133.2009.09195.x Published: 01 July 2009
A new biomarker in asthma
Authors: Ian Scott
Journal: Thorax (2008)

This is the first study to evaluate the pathogenic role of the novel chitinase-like protein YKL-40 in asthma. In experimental models, YKL-40 and chitinases promoted airway inflammation through type 2 helper T cells. This study investigated serum YKL-40 levels in asthma, including assessing relationships with disease severity, airway YKL-40 levels and airway remodelling. …
Value of caregiver ratings in evaluating the quality of life of patients with cancer.
Authors: K C Sneeuw, N K Aaronson, M A Sprangers, S B Detmar, L D Wever, J H Schornagel
Journal: Journal of Clinical Oncology (1997)

PURPOSE To evaluate the usefulness of caregiver ratings of cancer patients' quality of life (QL), we examined the following: (1) the comparability of responses to a brief standardized QL questionnaire provided by patients, physicians, and informal caregivers; and (2) the relative validity of these ratings. METHODS The study sample included cancer patients receiving chemotherapy, their treating physicians, and significant others involved closely in the (informal) care of the patients. During an early phase of treatment and 3 months later, patients and caregivers completed independently the COOP/WONCA charts, covering seven QL domains. At baseline, all sources of information were available for 295 of 320 participating patients (92%). Complete follow-up data were obtained for 189 patient-caregiver triads. RESULTS Comparison of mean scores on the COOP/WONCA charts revealed close agreement between patient and caregiver ratings. At the individual patient level, exact or global agreement was observed in the majority of cases (73% to 91%). Corrected for chance agreement, moderate intraclass correlations (ICC) were noted (0.32 to 0.72). Patient, physician, and informal caregiver COOP/WONCA scores were all responsive to changes over time in specific QL domains, but differed in their relative performance. Relative to the patients, the physicians were more efficient in detecting changes over time in physical fitness and overall health, but less so in relation to social function and pain. CONCLUSION For studies among patient populations at risk of deteriorating self-report capabilities, physicians and informal caregivers can be useful as alternative or complementary sources of information on cancer patients' QL.
Preclinical Evaluation of an 131I-Labeled Benzamide for Targeted Radiotherapy of Metastatic Melanoma
Authors: John L. Joyal, John A. Barrett, John C. Marquis, Jianqing Chen, Shawn M. Hillier, Kevin P. Maresca, Marie Boyd, Kenneth Gage, Sridhar Nimmagadda, James F. Kronauge, Matthias Friebe, Ludger Dinkelborg, James B. Stubbs, Michael G. Stabin, Rob Mairs, Martin G. Pomper, John W. Babich
Journal: Cancer Research (2010)

Radiolabeled benzamides are attractive candidates for targeted radiotherapy of metastatic melanoma as they bind melanin and exhibit high tumor uptake and retention. One such benzamide, N-(2-diethylamino-ethyl)-4-(4-fluoro-benzamido)-5-iodo-2-methoxy-benzamide (MIP-1145), was evaluated for its ability to distinguish melanin-expressing from amelanotic human melanoma cells, and to specifically localize to melanin-containing tumor xenografts. The binding of [(131)I]MIP-1145 to melanoma cells in vitro was melanin dependent, increased over time, and insensitive to mild acid treatment, indicating that it was retained within cells. Cold carrier MIP-1145 did not reduce the binding, consistent with the high capacity of melanin binding of benzamides. In human melanoma xenografts, [(131)I]MIP-1145 exhibited diffuse tissue distribution and washout from all tissues except melanin-expressing tumors. Tumor uptake of 8.82% injected dose per gram (ID/g) was seen at 4 hours postinjection and remained at 5.91% ID/g at 24 hours, with tumor/blood ratios of 25.2 and 197, respectively. Single photon emission computed tomography imaging was consistent with tissue distribution results. The administration of [(131)I]MIP-1145 at 25 MBq or 2.5 GBq/m(2) in single or multiple doses significantly reduced SK-MEL-3 tumor growth, with multiple doses resulting in tumor regression and a durable response for over 125 days. To estimate human dosimetry, gamma camera imaging and pharmacokinetic analysis was performed in cynomolgus monkeys. The melanin-specific binding of [(131)I]MIP-1145 combined with prolonged tumor retention, the ability to significantly inhibit tumor growth, and acceptable projected human dosimetry suggest that it may be effective as a radiotherapeutic pharmaceutical for treating patients with metastatic malignant melanoma.
Attenuation of NF-?B signalling in rat cardiomyocytes at birth restricts the induction of inflammatory genes
Authors: Nora Goren, Jimena Cuenca, Paloma Martín-Sanz, Lisardo Boscá
Journal: Cardiovascular Research (2004)

Objectives and background: The expression of inflammatory genes in the heart plays an important role in organ dysfunction. However, the contribution of cardiomyocytes to this process, and in particular to the synthesis of high concentrations of nitric oxide and prostaglandins, has not been analyzed in detail. For this reason, cultured isolated cardiomyocytes were used to evaluate the response to pro-inflammatory stimuli.
Focal epithelial hyperplasia of the mouth: recently discovered in South Africa
Authors: C.W. WYK
Journal: British Journal of Dermatology (1977)

Seventy-six cases of focal epithelial hyperplasia are encountered during an epidemiological survey in the Western Cape Province of South Africa. They affected only Cape Coloureds and were confined to pupils of reform schools and residents of a secluded community. This pattern of distribution, coupled with its typical clinical and histological features and the fact that viral particles were observed in lesions, indicates a communicable disease of viral origin, possibly a virus of the papova group. The recent discovery of its presence in South Africa indicates that it may be newly introduced into the country or that it is a new or hitheto undetected manifestation of an existing viral disease.
Cerebriform tongue—a clinical sign in pemphigus vegetans
Authors: S. PREMALATHA, S. JAYAKUMAR, PATRICK YESUDIAN, A.S. THAMBIAH
Journal: British Journal of Dermatology (1981)

Ten cases of pemphigus vegetans of Neumann type are reported. Six of these showed clinically distinctive changes in the tongue for which the term cerebriform tongue is proposed. Histological examination of the tongue showed typical features of pemphigus vegetans.
Mutation and Transformation of Cultured Mammalian Cells by &lt;italic&gt;N&lt;/italic&gt;-Acetoxy-&lt;italic&gt;N&lt;/italic&gt;-2-Fluorenylacetamide
Authors: E. Huberman, P. J. Donovan, J. A. DiPaolo
Journal: JNCI Journal of the National Cancer Institute (1972)

N-2-fluorenylacetamide (FAA) and its metabolic derivatives, N-hydroxy-N-2-fluorenylacetamide and N-acetoxy-N-2-fluorenyl-acetamide were studied in two cell systems: Chinese hamster for toxicity and mutagenicity and Syrian hamster (or toxicity and transformation. Cyto-toxicity (ratio of cloning efficiency of treated and control cells), mutagenicity (8-azaguanine-resistant colonies/105 cells), and transformation frequency (ratio of colonies exhibiting crisscross pattern to surviving treated colonies) increased with concentration and degree of reactivity of the derivative FAA.
Occupation, Asthma, and Chronic Respiratory Symptoms in a Community Sample of Older Women
Authors: FRANCESCO FORASTIERE, JOHN BALMES, MARINA SCARINCI, IRA B. TAGER
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

We evaluated the role of occupational factors on the prevalence of self-reported asthma, chronic bronchitis, and asthma-like respiratory symptoms among women ⩾ 55 yr. Occupational history, smoking, and respiratory conditions were collected through an interviewer-administered questionnaire from 1,226 women. Lung function data from 820 subjects were used for group "validation" of the outcome variables. Significant associations were observed between the respiratory conditions and occupational groupings based on the longest occupation held. Artists, writers, decorators, and photographers (odds ratio [OR] = 3.1), and women in service occupations (OR = 2.4) had a significantly increased risk of asthma. The odds of asthma-like symptoms was significantly elevated among nurses and other nonphysician health workers (OR = 2.9), social workers (OR = 2.9), and homemakers (OR = 2.4). Exposure to dusts, gas, vapors, fumes, or sensitizers was associated with a significantly increased odds of asthma (OR = 1.8) and with a marginally significant increased odds of asthma-like symptoms (OR = 1.4). Smoking accounted for a large proportion of asthma and asthma-like conditions in this population (population attributable risk [PAR] = 40.5% and 35.0%, respectively); employment in occupations with a high probability of exposures to dusts, gas, vapors, fumes, or sensitizers also contributed significantly to the burden of asthma (PAR = 15.1 to 20.0%) and asthma-like symptoms (PAR = 7.5 to 10.2%).
Yoga for anxiety: a systematic review of the research evidence
Authors: G Kirkwood, H Rampes, V Tuffrey, J Richardson, K Pilkington
Journal: British Journal of Sports Medicine (2005)

Between March and June 2004, a systematic review was carried out of the research evidence on the effectiveness of yoga for the treatment of anxiety and anxiety disorders. Eight studies were reviewed. They reported positive results, although there were many methodological inadequacies. Owing to the diversity of conditions treated and poor quality of most of the studies, it is not possible to say that yoga is effective in treating anxiety or anxiety disorders in general. However, there are encouraging results, particularly with obsessive compulsive disorder. Further well conducted research is necessary which may be most productive if focused on specific anxiety disorders.
Antioxidants, diabetes and endothelial dysfunction
Authors: D Laight
Journal: Cardiovascular Research (2000)

While a damaged endothelium is recognised to be a key accessory to diabetic macroangiopathy, awareness is developing that impairments concerning endothelium- and nitric oxide (NO)-dependent microvascular function, may contribute to several other corollaries of diabetes, such as hypertension, dyslipidaemia and in vivo insulin resistance. There are now several reports describing elevations in specific oxidant stress markers in both insulin resistance syndrome (IRS) and diabetes, together with determinations of reduced total antioxidant defence and depletions in individual antioxidants. Such a pro-oxidant environment in diabetes may disrupt endothelial function through the inactivation of NO, resulting in the attenuation of a fundamental anti-atherogenic and euglycaemic vascular influence. Indeed, experimental and clinical data suggest that the supplementation of insulin resistant or diabetic states with antioxidants such as vitamin E, normalises oxidant stress and improves both endothelium-dependent vasodilation and insulin sensitivity. However, the promising potential efficacy of antioxidant therapy in cardiovascular disease and diabetes, in either a primary or secondary preventative role, awaits definitive clinical demonstration.
Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease.
Authors: M F Kagnoff, Y J Paterson, P J Kumar, D D Kasarda, F R Carbone, D J Unsworth, R K Austin
Journal: Gut (1987)

We previously noted a region of amino acid sequence homology between A-gliadin, a major alpha-gliadin component known to activate coeliac disease, and the early region E1b protein of human adenovirus serotype 12 (Ad12), an adenovirus isolated from the human intestinal tract. In the present study sera from coeliac disease patients from the United Kingdom and the United States were assayed for neutralising antibody to Ad12 as evidence of past exposure to that virus and for antibody to synthetic peptides of A-gliadin from the region of shared sequence with the Ad12 E1b protein. Eighty nine per cent of untreated coeliac disease patients had evidence of previous Ad12 infection. There was also a significant increase in the prevalence of neutralising antibody to Ad12 among treated adults (33.3%) and children (30.8%) with coeliac disease compared with controls (0-12.8%) in the western USA and in London. There was no evidence for an increased prevalence of infection with a closely related adenovirus, adenovirus 18, or another enteric virus, Echovirus 11, among coeliac disease subjects. Additional studies documented that a region of A-gliadin that shares amino acid sequence homology with the adenovirus 12 E1b protein could be recognised as an antigenic determinant in active coeliac disease patients. Taken together, these data are compatible with the hypothesis that a viral protein may play a role in the pathogenesis of coeliac disease, perhaps by virtue of immunological cross reactivity between antigenic determinants shared by the viral protein and alpha-gliadins.
Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy
Authors: Pauline Maby, David Tougeron, Mohamad Hamieh, Bernhard Mlecnik, Hafid Kora, Gabriela Bindea, Helen K. Angell, Tessa Fredriksen, Nicolas Elie, Emilie Fauquembergue, Aurélie Drouet, Jérôme Leprince, Jacques Benichou, Jacques Mauillon, Florence Le Pessot, Richard Sesboüé, Jean-Jacques Tuech, Jean-Christophe Sabourin, Pierre Michel, Thierry Frébourg, Jérôme Galon, Jean-Baptiste Latouche
Journal: Cancer Research (2015)

Colorectal cancers with microsatellite instability (MSI) represent 15% of all colorectal cancers, including Lynch syndrome as the most frequent hereditary form of this disease. Notably, MSI colorectal cancers have a higher density of tumor-infiltrating lymphocytes (TIL) than other colorectal cancers. This feature is thought to reflect the accumulation of frameshift mutations in sequences that are repeated within gene coding regions, thereby leading to the synthesis of neoantigens recognized by CD8(+) T cells. However, there has yet to be a clear link established between CD8(+) TIL density and frameshift mutations in colorectal cancer. In this study, we examined this link in 103 MSI colorectal cancers from two independent cohorts where frameshift mutations in 19 genes were analyzed and CD3(+), CD8(+), and FOXP3(+) TIL densities were quantitated. We found that CD8(+) TIL density correlated positively with the total number of frameshift mutations. TIL densities increased when frameshift mutations were present within the ASTE1, HNF1A, or TCF7L2 genes, increasing even further when at least one of these frameshift mutations was present in all tumor cells. Through in vitro assays using engineered antigen-presenting cells, we were able to stimulate peripheral cytotoxic T cells obtained from colorectal cancer patients with peptides derived from frameshift mutations found in their tumors. Taken together, our results highlight the importance of a CD8(+) T cell immune response against MSI colorectal cancer-specific neoantigens, establishing a preclinical rationale to target them as a personalized cellular immunotherapy strategy, an especially appealing goal for patients with Lynch syndrome.
Value and Limitations of Measuring HER-2 Extracellular Domain in the Serum of Breast Cancer Patients
Authors: Alexandra F. Leary, Wedad M. Hanna, Marc J. van de Vijver, Frederique Penault-Llorca, Josef Rüschoff, Robert Y. Osamura, Michael Bilous, Mitch Dowsett
Journal: Journal of Clinical Oncology (2009)

The human epidermal receptor-2 (HER-2) is overexpressed or amplified in 15% to 25% of breast cancers. Determination of HER-2 tumor status offers clinically useful information, as it selects patients who may benefit from treatment with trastuzumab, the monoclonal antibody against HER-2. Currently approved methods for HER-2 testing include immunohistochemistry or fluorescent in situ hybridization using tumor tissue. A fragment of HER-2 composed of its extracellular domain (ECD) can also be detected in the serum of some patients with breast cancer. As an easily accessible tumor marker, it could offer additional useful prognostic or predictive information. This review will briefly address the biology of the circulating HER-2 ECD and discuss the evidence to support the role, if any, for measuring HER-2 ECD levels in women with breast cancer. In particular, we focus on the value and limitations of serum ECD in both early and advanced breast cancer in the following clinical contexts: as a marker of HER-2 tumor tissue status; clinical implications of raised levels in women who have a tumor not overexpressing HER-2; as a prognostic indicator and as a predictor of response to treatment; and as a monitoring tool for early recurrence. On the basis of our review of the literature, we conclude that there is currently insufficient evidence to support the use of serum HER-2 ECD in the routine management of individual patients with breast cancer. This conclusion is in agreement with the 2007 American Society of Clinical Oncology guidelines on the use of biomarkers in breast cancer.
Focal Cryotherapy for Clinically Unilateral, Low-Intermediate Risk Prostate Cancer in 73 Men with a Median Follow-Up of 3.7 Years
Authors: Duke Bahn, Andre Luis de Castro Abreu, Inderbir S. Gill, Andrew J. Hung, Paul Silverman, Mitchell E. Gross, Gary Lieskovsky, Osamu Ukimura
Journal: European Urology (2012)
Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system.
Authors: Guido Iaccarino, Michele Ciccarelli, Daniela Sorriento, Gennaro Galasso, Alfonso Campanile, Gaetano Santulli, Ersilia Cipolletta, Vincenzo Cerullo, Vincenzo Cimini, Giovanna Giuseppina Altobelli, Federico Piscione, Ornella Priante, Lucio Pastore, Massimo Chiariello, Francesco Salvatore, Walter J. Koch, Bruno Trimarco
Journal: Circulation Research (2005)

Beta2-adrenergic receptors (beta2ARs) are widely expressed, although their physiological relevance in many tissues is not yet fully understood. In vascular endothelial cells, they regulate NO release and vessel tone. Here we provide novel evidence that beta2ARs can regulate neoangiogenesis in response to chronic ischemia. We used in vivo adenoviral-mediated gene transfer of the human beta2AR to the endothelium of the rat femoral artery and increased beta2AR signaling resulting in ameliorated angiographic blood flow and hindlimb perfusion after chronic ischemia. Histological analysis confirmed that beta2AR overexpression also produced benefits on capillary density. The same maneuver partially rescued impaired angiogenesis in spontaneously hypertensive rats (SHR), whereas gene delivery of the G-protein-coupling defective mutant Ile164 beta2AR failed to provide ameliorations. Stimulation of endogenous and overexpressed beta2AR on endothelial cells in vitro was found to regulate cell number by inducing proliferation and [3H]-thymidine incorporation through means of extracellular receptor-activated kinase and vascular endothelial growth factor. The beta2AR also has novel effects on endothelial cell number through stimulation of proapoptosis and antiapoptosis pathways involving p38 mitogen-activated protein kinase and PI3-kinase/Akt activation. Therefore, beta2ARs play a critical role in endothelial cell proliferation and function including revascularization, suggesting a novel and physiologically relevant role in neoangiogenesis in response to ischemia.
The relationships between smoking and anxiety and depression in people with COPD – Implications for smoking cessation treatment for people with COPD
Authors: Kristin Rosa Armannsdottir, Helga Jonsdottir
Journal: European Respiratory Journal (2014)

Background  Smoking cessation is the most significant action that people with chronic obstructive pulmonary disease (COPD) undertake to hinder the progression of the disease. Smoking is strongly related to anxiety and mood disorders. The prevalence of anxiety and depression in people with COPD is considerable. The research question is: What is the relationship between continued smoking and anxiety and depression as measured by the Hospital Anxiety and Depression Scale (HADS) in people with COPD?   Method and participants  Cross-sectional study design. Participants were recruited from primary health care centers and lung physicians9 offices (N=100). Two thirds (73%) were on GOLD stage I & II and on third (27%) on GOLD stage III & IV. Mean age was 59 years, 46 men and 54 women. All had smoked at one time but 40% had quit. There was no difference in smoking rate between men and women or level of education.   Results  There was no difference in smoking rate in GOLD stage I & II compared to stage III & IV (p=0.14). Smoking rate was 68% in  61 y.o. (p=0.06). Patients who still smoked had significantly more anxiety (p=0.01) compared to ex-smokers. There was no relationship between smoking and depression.   Conclusion  The significance that anxiety has in continued smoking in people with COPD may be of major importance in establishing effective smoking cessation treatments for people with COPD.