Denosumab for Tumor-Induced Hypercalcemia Complicated by Renal Failure
Authors: Anneke Bech, Hans de Boer
Journal: Annals of Internal Medicine (2012)

Letters19 June 2012Denosumab for Tumor-Induced Hypercalcemia Complicated by Renal FailureAnneke Bech, MD and Hans de Boer, MD, PhDAnneke Bech, MDFrom Rijnstate Hospital, 6800 TA Arnhem, the Netherlands. and Hans de Boer, MD, PhDFrom Rijnstate Hospital, 6800 TA Arnhem, the Netherlands.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-12-201206190-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Multiple myeloma is characterized by development of osteolytic bone lesions induced by myeloma cells that produce cytokines. The cytokines activate preosteoblastic stromal cells to secrete the receptor activator of nuclear factor-κ ligand (RANK-L). This is a key signal to stimulate osteoclast formation and activity (1). Increased bone resorption may lead to hypercalcemia in more than 30% of patients with multiple myeloma.Standard treatment of cancer-induced hypercalcemia comprises forced hydration, calcitonin, and intravenous first-line bisphosphonates. In patients with cancer who have creatinine clearance less than 60 mL/min per 1.73 m2, bisphosphonates can cause deterioration of renal function in about 20% ...References1. Lumachi F, Brunello A, Roma A, Basso U. Cancer-induced hypercalcemia. Anticancer Res. 2009;29:1551-5. [PMID: 19443365] MedlineGoogle Scholar2. Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol. 2010;28:5132-9. [PMID: 21060033] CrossrefMedlineGoogle Scholar3. Body JJ, Lipton A, Gralow J, Steger GG, Gao G, Yeh H, et al. Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure. J Bone Miner Res. 2010;25:440-6. [PMID: 19653815] CrossrefMedlineGoogle Scholar4. Henry DH, Costa L, Goldwasser F, Hirsh V, Hungria V, Prausova J, et al. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J Clin Oncol. 2011;29:1125-32. [PMID: 21343556] CrossrefMedlineGoogle Scholar5. Fizazi K, Carducci M, Smith M, Damião R, Brown J, Karsh L, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet. 2011;377:813-22. [PMID: 21353695] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Rijnstate Hospital, 6800 TA Arnhem, the Netherlands.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySuccessful treatment with denosumab for two cases with hypercalcemia due to vitamin D intoxication and associated acute kidney injuryControversies in the use of new bone‐modifying therapies in multiple myelomaAnswer to: "Asterixis as an atypical expression of hypercalcemia"Respuesta a: «Asterixis como forma de presentación atípica de hipercalcemia»Hyperkalzämie: Häufig steckt eine Tumorerkrankung dahinterParathyroid hormone independent hypercalcemia in adultsMetabolische Entgleisungen als paraneoplastische SyndromeDenosumab Use For Severe Hypercalcemia In A Man With End-Stage Renal Disease On HemodialysisDenosumab: a new agent in the management of hypercalcemia of malignancyHypercalcemia in the Intensive Care UnitAcute Management of HypercalcemiaUse of denosumab in parathyroid carcinoma with refractory hypercalcemiaDenosumab for Management of Parathyroid Carcinoma-Mediated HypercalcemiaManagement of Treatment Complications and Supportive CareDenosumab for treatment of immobilization-related hypercalcaemia in a patient with advanced renal failure 19 June 2012Volume 156, Issue 12Page: 906-907KeywordsCalciumCreatinineHypercalcemiaLesionsMultiple myelomaOsteoclastsRenal cancerRenal failureSerum albuminSodium chloride ePublished: 19 June 2012 Issue Published: 19 June 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...