New Concepts in the Pathophysiology of Inflammatory Bowel Disease
Authors: Giorgos Bamias, Mark R. Nyce, Sarah A. De La Rue, Fabio Cominelli
Journal: Annals of Internal Medicine (2005)

Reviews20 December 2005New Concepts in the Pathophysiology of Inflammatory Bowel DiseaseGiorgos Bamias, MD, Mark R. Nyce, MD, Sarah A. De La Rue, PhD, and Fabio Cominelli, MD, PhDGiorgos Bamias, MDFrom University of Virginia, Charlottesville, Virginia., Mark R. Nyce, MDFrom University of Virginia, Charlottesville, Virginia., Sarah A. De La Rue, PhDFrom University of Virginia, Charlottesville, Virginia., and Fabio Cominelli, MD, PhDFrom University of Virginia, Charlottesville, Virginia.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-12-200512200-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Clinical PrinciplesThe inflammatory bowel diseases (IBDs), that is, Crohn disease and ulcerative colitis, affect approximately 1 million persons in North America and several million persons worldwide.Approximately 30% of patients present between 10 and 30 years of age.Current therapeutic options are limited and include nonspecific anti-inflammatory and immunosuppresive medications.Surgery is required for 50% to 80% of patients with Crohn disease, while only 20% of patients with ulcerative colitis have surgery.Novel biological therapeutics have greatly improved the quality of life of patients with IBD.Pathophysiologic PrinciplesBoth genetic and environmental factors play important roles in disease pathogenesis.New hypotheses implicate the innate immune system and ...References1. 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High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study. Dig Dis Sci. 2004;49:1280-6. [PMID: 15387358] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Virginia, Charlottesville, Virginia.Acknowledgments: The authors thank the entire personnel of the Digestive Health Center of Excellence at the University of Virginia.Grant Support: By the United States Public Health Service/National Institutes of Health grants DK-42195, DK-44540, and DK-55812 to Fabio Cominelli and The UVa Digestive Health Research Center (P30 DK-67629).Disclosures: Honoraria: F. Cominelli (UCB Pharmaceuticals, Inc., Centocor, Elan, Sigma-Tau).Corresponding Author: Fabio Cominelli, MD, PhD, Division of Gastroenterology and Hepatology, P.O. Box 800708, University of Virginia Health System, Charlottesville, VA 22908; e-mail, [email protected]edu.Current Author Addresses: Drs. Bamias, Nyce, De La Rue, and Cominelli: Digestive Health Center of Excellence, University of Virginia, P.O. Box 800708, Charlottesville, VA 22908-0708. 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