tbuckley/cabot-search huggingface dataset:
Prognostic role of B-type natriuretic peptide levels in patients with type 2 diabetes mellitus
Authors: Meenakshi A. Bhalla, Audrey Chiang, Victoria A. Epshteyn, Radmila Kazanegra, Vikas Bhalla, Paul Clopton, Padma Krishnaswamy, L.K. Morrison, Albert Chiu, Nancy Gardetto, Sunder Mudaliar, Steven V. Edelman, Robert R. Henry, Alan S. Maisel
Journal: Journal of the American College of Cardiology (2004)
Control of Skin Sympathetic Nerve Activity During Intermittent Static Handgrip Exercise
Authors: Urs A. Leuenberger, Sogol Mostoufi-Moab, Michael Herr, Kristen Gray, Allen Kunselman, Lawrence I. Sinoway
Journal: Circulation (2003)

Background— Exercise activates the sympathetic nervous system as a function of the type and intensity of exercise and of the target organ studied. Although central command and activity of metabolically sensitive afferents from exercising muscle are the principal determinants of sympathetic outflow directed to skeletal muscle, the mechanisms that govern sympathetic outflow directed to skin are less clear. Methods and Results— We measured skin sympathetic nerve activity (SSNA) during intermittent static handgrip (SHG; at 45% of maximal voluntary contraction; four 5-second contractions per minute for 3 minutes), during unrestricted forearm perfusion (control), during stimulation of forearm mechanoreceptors with venous congestion, and during ischemia produced by forearm circulatory arrest. Under all 3 conditions, SSNA increased within 1 to 2 seconds of the onset of handgrip. During ischemia but not during venous congestion, SSNA increased more compared with control ( P &lt;0.05) and remained elevated when forearm ischemia was maintained after handgrip exercise (posthandgrip circulatory arrest). In addition, simulated handgrip and intermittent forearm compression produced by a pneumatic cuff also evoked brief increases of SSNA. Conclusions— In addition to central neural factors, afferent input from exercising muscle plays an important role in modulating sympathetic outflow directed to skin.
Sclerosing cholangitis associated with multifocal fibrosis: a case report.
Authors: R D Laitt, S G Hubscher, J A Buckels, S Darby, E Elias
Journal: Gut (1992)

The association of sclerosing cholangitis, retroperitoneal fibrosis, and Riedel9s thyroiditis has been reported twice before, and on both occasions the authors successfully used steroids to control the fibrotic process. A further case of fibrosis with this triad of organ involvement in which a combination of surgery and steroid treatment has arrested disease progression is described. This suggests an inappropriate immune response in this type of fibrotic overlap syndrome.
Treatment of Atherosclerotic Renal Artery Stenosis
Authors: Alberto Morganti, Chiara Bencini, Cecilia Del Vecchio, Maria Strata
Journal: Journal of the American Society of Nephrology (2002)

ABSTRACT. The increasing prevalence of atherosclerotic renal artery stenosis (ARAS) has prompted in recent years a more aggressive treatment of this condition for reducing BP and for preserving the jeopardized renal function. Percutaneous transluminal renal angioplasty (PTRA), alone or in conjunction with stent implantation, may be useful for both these goals. However, despite the methodological improvements that make this procedure much safer than surgery, caution must be applied before PTRA is extended to all patients with ARAS. Indeed, PTRA is associated with a 23% rate of major/minor complications and with a 20% rate of restenosis, even in arteries implanted with stent. Moreover the cure rate of hypertension achievable with PTRA is, at best, around 10%, with a 40% rate of improvements. Even for rescuing the ischemic kidney, PTRA/stent implantation are not always effective; only 35% of patients with ARAS have some improvement in renal function. These data indicate that there is an urgent need of rigorous criteria for selecting among the many patients with ARAS those who may actually benefit from the dilation procedure. E-mail: [email protected]
Early cardiotoxicity of the CHOP regimen in aggressivenon-Hodgkin’s lymphoma
Authors: S. Limat, K. Demesmay, L. Voillat, Y. Bernard, E. Deconinck, A. Brion, A. Sabbah, M.C. Woronoff-Lemsi, J.Y. Cahn
Journal: Annals of Oncology (2003)
Improved Overall Survival With Oxaliplatin, Fluorouracil, and Leucovorin As Adjuvant Treatment in Stage II or III Colon Cancer in the MOSAIC Trial
Authors: Thierry André, Corrado Boni, Matilde Navarro, Josep Tabernero, Tamas Hickish, Clare Topham, Andrea Bonetti, Philip Clingan, John Bridgewater, Fernando Rivera, Aimery de Gramont
Journal: Journal of Clinical Oncology (2009)

PURPOSE Three-year disease-free survival (DFS) was significantly improved in patients who had undergone resection with curative intent for stage II or III colon cancer who received bolus plus continuous-infusion fluorouracil plus leucovorin (LV5FU2) with the addition of oxaliplatin (FOLFOX4). Final results of the study, including 6-year overall survival (OS) and 5-year updated DFS, are reported. PATIENTS AND METHODS A total of 2,246 patients were randomly assigned to receive LV5FU2 or FOLFOX4 for 6 months. The primary end point was DFS. Secondary end points were OS and safety. Results Five-year DFS rates were 73.3% and 67.4% in the FOLFOX4 and LV5FU2 groups, respectively (hazard ratio [HR] = 0.80; 95% CI, 0.68 to 0.93; P = .003). Six-year OS rates were 78.5% and 76.0% in the FOLFOX4 and LV5FU2 groups, respectively (HR = 0.84; 95% CI, 0.71 to 1.00; P = .046); corresponding 6-year OS rates for patients with stage III disease were 72.9% and 68.7%, respectively (HR = 0.80; 95% CI, 0.65 to 0.97; P = .023). No difference in OS was seen in the stage II population. The incidence of second noncolorectal cancers was 5.5% and 6.1% in the FOLFOX4 and LV5FU2 groups, respectively. Among patients receiving oxaliplatin, the frequency of grade 3 peripheral sensory neuropathy was 1.3% 12 months after treatment and 0.7% at 48 months. CONCLUSION Adding oxaliplatin to LV5FU2 significantly improved 5-year DFS and 6-year OS in the adjuvant treatment of stage II or III colon cancer and should be considered after surgery for patients with stage III disease.
Predictive and Prognostic Analysis of PIK3CA Mutation in Stage III Colon Cancer Intergroup Trial
Authors: Shuji Ogino, Xiaoyun Liao, Yu Imamura, Mai Yamauchi, Nadine J. McCleary, Kimmie Ng, Donna Niedzwiecki, Leonard B. Saltz, Robert J. Mayer, Renaud Whittom, Alexander Hantel, Al B. Benson, Rex B. Mowat, Donna Spiegelman, Richard M. Goldberg, Monica M. Bertagnolli, Jeffrey A. Meyerhardt, Charles S. Fuchs
Journal: JNCI Journal of the National Cancer Institute (2013)

Somatic mutations in PIK3CA (phosphatidylinositol-4,5-bisphosphonate 3-kinase [PI3K], catalytic subunit alpha gene) activate the PI3K-AKT signaling pathway and contribute to pathogenesis of various malignancies, including colorectal cancer. We examined associations of PIK3CA oncogene mutation with relapse, survival, and treatment efficacy in 627 stage III colon carcinoma case subjects within a randomized adjuvant chemotherapy trial (5-fluorouracil and leucovorin [FU/LV] vs irinotecan [CPT11], fluorouracil and leucovorin [IFL]; Cancer and Leukemia Group B 89803 [Alliance]). We detected PIK3CA mutation in exons 9 and 20 by polymerase chain reaction and pyrosequencing. Cox proportional hazards model was used to assess prognostic and predictive role of PIK3CA mutation, adjusting for clinical features and status of routine standard molecular pathology features, including KRAS and BRAF mutations and microsatellite instability (mismatch repair deficiency). All statistical tests were two-sided. Compared with PIK3CA wild-type cases, overall status of PIK3CA mutation positivity or the presence of PIK3CA mutation in either exon 9 or 20 alone was not statistically significantly associated with recurrence-free, disease-free, or overall survival (log-rank P > .70; P > .40 in multivariable regression models). There was no statistically significant interaction between PIK3CA and KRAS (or BRAF) mutation status in survival analysis (Pinteraction > .18). PIK3CA mutation status did not appear to predict better or worse response to IFL therapy compared with FU/LV therapy (Pinteraction > .16). Overall tumor PIK3CA mutation status is not associated with stage III colon cancer prognosis. PIK3CA mutation does not appear to serve as a predictive tumor molecular biomarker for response to irinotecan-based adjuvant chemotherapy.
Riposte! Health professions in sports medicine.
Authors: D. A. Hill
Journal: British Journal of Sports Medicine (1978)

The article by J. G. P. Williams is confusing.Precisely what is he recommending?Paragraph five seems to suggest that medically qualified practitioners should form their own specific interest group.Other professions have, in fact, given a lead in this course of action e.g. the Association of Chartered Physiotherapists in Sports Medicine.It would certainly seem a good idea for medical practitioners to follow suit.But this is not the business of the multi-disciplinary BASM.Williams should test the feasibility of such a procedure by contacting medical practitioners via journals aimed specifically at the medical profession.
STUDIES ON THE RELATIONSHIP OF STREPTOCOCCUS HEMOLYTICUS TO THE RHEUMATIC PROCESS
Authors: Alvin F. Coburn, Ruth H. Pauli
Journal: The Journal of Experimental Medicine (1932)

To determine the nature of the organisms associated with outbreaks of rheumatism at The Pelham Home, in a large number of individuals at the Presbyterian Hospital Nurses' Training School and among rheumatic subjects in New York City under continuous clinical observation, studies of the throat flora have been conducted. Hemolytic streptococcus in most instances appeared in the pharynx from 1 to 5 weeks before the onset of the rheumatic attack. These organisms have been investigated with the usual types of bacteriological tests and, in addition, have been classified serologically according to Lancefield's technique. The results have demonstrated that the organisms were not of a single type, but fell into six antigenic groups. The majority of the freshly isolated strains tested were strong toxin producers. The organisms producing the strongest toxin were cultures from the patients who developed extremely intense rheumatism. About 70 per cent of these toxins were neutralized by a monovalent streptococcus antiserum.
Randomised phase III study of neoadjuvant chemotherapy with methotrexate, doxorubicin, vinblastine and cisplatin followed by radical cystectomy compared with radical cystectomy alone for muscle-invasive bladder cancer: Japan Clinical Oncology Group Study JCOG0209
Authors: H. Kitamura, T. Tsukamoto, T. Shibata, N. Masumori, H. Fujimoto, Y. Hirao, K. Fujimoto, Y. Kitamura, Y. Tomita, K. Tobisu, M. Niwakawa, S. Naito, M. Eto, Y. Kakehi
Journal: Annals of Oncology (2014)
Compromised Autoregulatory Control of Ocular Hemodynamics in Glaucoma Patients after Postural Change
Authors: Peter Galambos, Joanna Vafiadis, Silvia E. Vilchez, Lars Wagenfeld, Eike T. Matthiessen, Gisbert Richard, Maren Klemm, Oliver Zeitz
Journal: Ophthalmology (2006)
Association Between Type of Dietary Fish and Seafood Intake and the Risk of Incident Type 2 Diabetes
Authors: Pinal S. Patel, Stephen J. Sharp, Robert N. Luben, Kay-Tee Khaw, Sheila A. Bingham, Nicholas J. Wareham, Nita G. Forouhi
Journal: Diabetes Care (2009)

OBJECTIVE To investigate the association between fish and seafood intake and new-onset type 2 diabetes. RESEARCH DESIGN AND METHODS This was a population-based prospective cohort (European Prospective Investigation of Cancer [EPIC]-Norfolk) study of men and women aged 40–79 years at baseline (1993–1997). Habitual fish and seafood intake (white fish, oily fish, fried fish, and shellfish) was assessed using a semiquantitative food frequency questionnaire and categorized as less than one or one or more portions/week. During a median (interquartile range) follow-up of 10.2 (9.1–11.2) years, there were 725 incident diabetes cases among 21,984 eligible participants. RESULTS Higher total fish intake (one or more versus less than one portions/week) was associated with a significantly lower risk of diabetes (odds ratio [OR] 0.75 [95% CI 0.58–0.96]), in analyses adjusted for age, sex, family history of diabetes, education, smoking, physical activity, dietary factors (total energy intake, alcohol intake, and plasma vitamin C) and obesity (BMI and waist circumference). White fish and oily fish intakes were similarly inversely associated with diabetes risk, but the associations were not significant after adjustment for dietary factors (oily fish) or obesity (white fish). Fried fish was not significantly associated with diabetes risk. Consuming one or more portions/week of shellfish was associated with an increased risk of diabetes (OR 1.36 [1.02–1.81]) in adjusted analyses. CONCLUSIONS Total, white, and oily fish consumption may be beneficial for reducing risk of diabetes, reinforcing the public health message to consume fish regularly. Greater shellfish intake seems to be associated with an increased risk of diabetes, warranting further investigation into cooking methods and mechanisms.
Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial
Authors: Michel Bolla, Laurence Collette, Léo Blank, Padraig Warde, Jean Bernard Dubois, René-Olivier Mirimanoff, Guy Storme, Jacques Bernier, Abraham Kuten, Cora Sternberg, Johan Mattelaer, José Lopez Torecilla, J Rafael Pfeffer, Carmel Lino Cutajar, Alfredo Zurlo, Marianne Pierart
Journal: The Lancet (2002)
A COMPARATIVE STUDY OF SUBCUTANEOUS NODULES IN RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS
Authors: M. H. Dawson
Journal: The Journal of Experimental Medicine (1933)

The foregoing comparative study on the subcutaneous nodules in rheumatic fever and rheumatoid arthritis is presented as part of an investigation which has been conducted in this clinic on the relationship of the two clinical entities, rheumatic fever and rheumatoid arthritis. It is believed that the present study has shown that these lesions are highly characteristic of the two diseases and that they represent different phases of the same, fundamental, pathological process. However, it should be pointed out that the presence of closely related or even identical lesions in two, separate, clinical entities cannot be considered as valid evidence in support of the hypothesis that the two diseases are etiologically related. Comparative clinical studies on the relationship of rheumatic fever and rheumatoid arthritis will be presented in a succeeding communication. These studies, as well as serological investigations on the two diseases which have been reported elsewhere (23, 24), lend further support to the conception that rheumatic fever and rheumatoid arthritis are intimately related and possibly different responses of affected individuals to the same etiological agent.
Phase II trial of single-agent oral vinorelbine in elderly (≥70 years) patients with advanced non-small-cell lung cancer and poor performance status
Authors: A Camerini, C Valsuani, F Mazzoni, O Siclari, C Puccetti, S Donati, M Rondini, G Tartarelli, P Puccinelli, F Di Costanzo, D Amoroso
Journal: Annals of Oncology (2009)
Quantitation of p95HER2 in Paraffin Sections by Using a p95-Specific Antibody and Correlation with Outcome in a Cohort of Trastuzumab-Treated Breast Cancer Patients
Authors: Jeff Sperinde, Xueguang Jin, Jayee Banerjee, Elicia Penuel, Anasuya Saha, Gundo Diedrich, Weidong Huang, Kim Leitzel, Jodi Weidler, Suhail M. Ali, Eva-Maria Fuchs, Christian F. Singer, Wolfgang J. Köstler, Michael Bates, Gordon Parry, John Winslow, Allan Lipton
Journal: Clinical Cancer Research (2010)

Abstract Purpose: p95HER2 is an NH2-terminally truncated form of HER2 that lacks the trastuzumab binding site and is therefore thought to confer resistance to trastuzumab treatment. In this report, we introduce a new antibody that has enabled the first direct quantitative measurement of p95HER2 in formalin-fixed paraffin-embedded (FFPE) breast cancer tissues. We sought to show that quantitative p95HER2 levels would correlate with outcome in trastuzumab-treated HER2-positive metastatic breast cancer. Experimental Design: The novel p95HER2 antibody used here was characterized for sensitivity, specificity, and selectivity over full-length HER2. Quantitative p95HER2 levels were measured in 93 metastatic breast tumors using a VeraTag FFPE assay to determine the correlation of p95HER2 levels with outcomes. Results: Within a cohort of trastuzumab-treated metastatic breast cancer patients, high levels of p95HER2 were found to correlate with shorter progression-free survival [hazard ratio (HR), 1.9; P = 0.017] and overall survival (HR, 2.2; P = 0.012) in patients with tumors selected to be HER2 positive by the VeraTag HER2 assay. For those with tumors found to be fluorescence in situ hybridization positive, elevated p95HER2 correlated similarly with shorter progression-free survival (HR, 1.8; P = 0.022) and overall survival (HR, 2.2; P = 0.009). Conclusions: We have successfully generated an antibody that can specifically detect p95HER2, and developed an assay to quantify expression in FFPE tumor specimens. Using this novel assay, we have identified a group of HER2-positive patients expressing p95HER2 that have a worse outcome while on trastuzumab. As p95HER2 retains sensitivity to kinase inhibitors, measurement of p95HER2 in breast tumor sections may be useful in guiding treatment for patients with HER2-positive breast cancer. Clin Cancer Res; 16(16); 4226–35. ©2010 AACR.
Effect of diet on energy expenditure and plasma norepinephrine in lean and obese Pima Indians
Authors: Rebecca D. Kush, James B. Young, Harvey L. Katzeff, Elliot Danforth, John S. Garrow, Karl Scheidegger, Eric Ravussin, Barbara V. Howard, Ethan A.H. Sims, Edward S. Horton, Lewis Landsberg
Journal: Metabolism (1986)
Functional Redundancy of SWI/SNF Catalytic Subunits in Maintaining Vascular Endothelial Cells in the Adult Heart
Authors: Monte S. Willis, Jonathon W. Homeister, Gary B. Rosson, Yunus Annayev, Darcy Holley, Stephen P. Holly, Victoria J. Madden, Virginia Godfrey, Leslie V. Parise, Scott J. Bultman
Journal: Circulation Research (2012)

Rationale: Mating type swi tching/sucrose n on-fermenting (SWI/SNF) chromatin-remodeling complexes utilize either BRG1 or BRM as a catalytic subunit to alter nucleosome position and regulate gene expression. BRG1 is required for vascular endothelial cell (VEC) development and embryonic survival, whereas BRM is dispensable. Objective: To circumvent embryonic lethality and study Brg1 function in adult tissues, we used conditional gene targeting. To evaluate possible Brg1-Brm redundancy, we analyzed Brg1 mutant mice on wild-type and Brm -deficient backgrounds. Methods and Results: The inducible Mx1-Cre driver was used to mutate Brg1 in adult mice. These conditional-null mutants exhibited a tissue-specific phenotype and unanticipated functional compensation between Brg1 and Brm . Brg1 single mutants were healthy and had a normal lifespan, whereas Brg1/Brm double mutants exhibited cardiovascular defects and died within 1 month. BRG1 and BRM were required for the viability of VECs but not other cell types where both genes were also knocked out. The VEC phenotype was most evident in the heart, particularly in the microvasculature of the outer myocardium, and was recapitulated in primary cells ex vivo. VEC death resulted in vascular leakage, cardiac hemorrhage, secondary death of cardiomyocytes due to ischemia, and ventricular dissections. Conclusions: BRG1-catalyzed SWI/SNF complexes are particularly important in cardiovascular tissues. However, in contrast to embryonic development, in which Brm does not compensate, Brg1 is required in adult VECs only when Brm is also mutated. These results demonstrate for the first time that Brm functionally compensates for Brg1 in vivo and that there are significant changes in the relative importance of BRG1- and BRM-catalyzed SWI/SNF complexes during the development of an essential cell lineage.
Serendipitous Breast Lesions on Magnetic Resonance Imaging: Why Is This Lesion Different From All Other Lesions?
Authors: L. Kessler, R. J. Brenner
Journal: JNCI Journal of the National Cancer Institute (1998)

the local mammographer, refers a patient with a suspicious lesion that he doesn't think is cancer to the local magnetic resonance imaging (MRI) machine for a further test.The result confirms his suspicion: the lesion he had seen on mammography appears benign and there is no apparent worry.However, unexpected news arrived in the report: there is another lesion in the same breast that had not been detected by the initial mammogram.Dr. Gamliel is about to recommend surgical biopsy when his expert colleague says she has just read an article in the Journal of the National Cancer Institute about these lesions and the patient need not be sent for any invasive procedures.Astonished, Dr. Gamliel asks his colleague, ''Why is this lesion different from all other lesions''?When his colleague has no satisfactory answer, he returns home to ponder the problem.Dr. Gamliel sat down at dinner faced with the intriguing challenge of the question at hand and immediately recognized that he had four children who could help him formulate an answer.He gave them a copy of the paper by Lawrence et al. (1), published in this issue of the Journal, and decided to pose to each of them a single question that would, in part, address the initial question and help develop a more complete answer.He asked his first-born son, the official at the country's most powerful regulatory agency: ''What do the label and promotional claims of the MRI manufacturer say regarding incidental lesions''?(He did not like the label ''serendipitous''-it just seemed to have the wrong connotation.)
Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
Authors: Keitaro Matsuo, Ritsuro Suzuki, Nobuyuki Hamajima, Michinori Ogura, Yoshitoyo Kagami, Hirofumi Taji, Eisei Kondoh, Satoko Maeda, Shoji Asakura, Sadayuki Kaba, Shigeo Nakamura, Masao Seto, Yasuo Morishima, Kazuo Tajima
Journal: Blood (2001)