tbuckley/cabot-search huggingface dataset:
Abstract 1383: High levels of CD109+ circulating endothelial cells and progenitors as marker of response to bevacizumab and irinotecan in high grade gliomas
Authors: Lucia Cuppini, Serena Pellegatta, Angelica Calleri, Maria Grazia Bruzzone, Elena Prodi, Elena Anghileri, Patrizia Mancuso, Francesco Bertolini, Gaetano Finocchiaro, Marica Eoli
Journal: Cancer Research (2012)

Abstract Purpose: Bevacizumab, an anti-VEGF antibody, has shown significant activity in high grade gliomas (HGG). Previous studies emphasized the need for predictive markers of response. Experimental Design: We treated 63 recurrent HGG patients with poor prognostic factors with bevacizumab (10 mg/kg) and irinotecan (125 or 340 mg/m2) every 2 weeks, and investigated the predictive potential of circulating endothelial cells (CECs) and their progenitors (CEPs). Results: After a median follow-up of 27 weeks, median OS and PFS were 33 and 18 weeks, respectively. PFS at 6 and 12 months were 32% and 12%. OS at 6 months was 60%. No complete response but fourteen partial responses according to RANO criteria were observed. Toxicity and side effects were mild. Patients with distant intracerebral disease or leptomeningeal dissemination at baseline MRI had shorter PFS (p=0.002; p=0.01) and OS (p=0.005; p=0.03). Baseline CEP over 32.8 cells/ml (1st quartile) or CD45dimCD34+CD133+ hematopoietic committed progenitors over 27 cells/ml (1st quartile) were associated with an increased PFS (p=0.01; p=0.001, respectively). Baseline CD109+ CECs over 47.5 cells/ml (2nd quartile) were associated with longer PFS and OS (p= 0.001; p=0.02). Patients who progressed after 18 weeks of therapy or more (n=22) had baseline levels of CD109+ CECs and CD45dimCD34+VEGFR2+ cells significantly higher than others (p=0.008; p=0.04, respectively). At progression no significant change in CEC and CEP was detected. Conclusions: The data point to baseline CD109+ CECs, CEP and CD45dimCD34+CD133+ hematopoietic committed progenitors as promising markers for the selection of patients who could benefit from bevacizumab in the treatment of HGG. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1383. doi:1538-7445.AM2012-1383
Abstract 3671: A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression
Authors: Thomas Wiesner, Rajmohan Murali, Isabella Fried, Lorenzo Cerroni, Heinz Kutzner, Boris C. Bastian
Journal: Cancer Research (2012)

Abstract We recently reported that germline mutations in BAP1 cause a familial tumor syndrome characterized by high penetrance for melanocytic tumors with distinctive clinical and histologic features. Melanocytic neoplasms in affected individuals harbored BRAF mutations, showed loss of BAP1 expression, and histologically resembled so-called “atypical Spitz tumors” (ASTs). ASTs are an ill-defined and probably heterogenous group of melanocytic tumors that display histologic features seen in both Spitz nevi and melanomas. Their biologic behavior cannot be reliably predicted. Based on the histologic similarities of the familial tumors and ASTs, we hypothesized that a subset of ASTs might harbor genetic alterations seen in the familial tumors. To address this hypothesis, we analyzed 32 sporadic ASTs for BRAF mutations, and for BAP1 expression. To determine the utility of immunohistochemistry to assess BAP1 status, we analyzed samples from 42 patients with the above syndrome as well as 46 melanocytic nevi and found that loss of BAP1 expression was restricted to patients with the syndrome. Nine (28%) sporadic ASTs showed loss of BAP1 expression, of which of 8 (89%) had concomitant BRAF mutations. Only one of the BAP1-positive ASTs (4%) had a BRAF mutation (p&amp;lt;0.0001). BRAF mutated, BAP1-negative tumors were primarily located in the dermis, and were composed entirely or predominantly of epithelioid melanocytes with abundant amphophilic cytoplasm and well-defined cytoplasmic borders. Nuclei were commonly vesicular, and exhibited substantial pleomorphism and conspicuous nucleoli. The combination of BRAF mutation and loss of nuclear BAP1 expression thus characterizes a subset of ASTs with distinctive histologic features. The typical morphology of these tumors and BAP1 immunohistochemistry provide pathologic clues that will enable accurate identification of this subset. Future studies are necessary to determine whether this subset has a predictable clinical behavior. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3671. doi:1538-7445.AM2012-3671
Endoscopic diagnosis and treatment of tumors
Authors: L. Aabakken
Journal: Endoscopy (2009)

As in previous years, this topic overlaps with a number of the other topics reviewed in this series. Thus, the focus in this paper will again be gastric tumors, since the esophagus, small and large bowel, endoscopic ultrasound (EUS), and endoscopic retrograde cholangiopancreatography (ERCP) are covered elsewhere.
AB0264 Comparison of drug survival, safety and doses of etanercept, infliximab and adalimumab in rheumatoid arthritis patients: thirteen years canadian clinical practice experience.
Authors: A. Chow, E. Soucy, A. Shah, M. Got
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> TNF-α inhibitors etanercept, infliximab and adalimumab have been used for more than 10 years to treat moderate to severe rheumatoid arthritis (RA). Different studies reported different drug survival rate for these drugs. Clinical practice also shows that not all RA patients respond to the 3 mg per kg dose of infliximab, leading some rheumatologists to use higher doses and/or reduce the dosing interval for infliximab. <h3>Objectives</h3> The purposes of this study are to compare drug survival between etanercept, infliximab and adalimumab when used with or without concomitant methotrexate, to compare dosing pattern and safety profile between these three agents in RA patients from our more than 12 years clinical experience. <h3>Methods</h3> A total 297 RA patients treated with etancercept, infliximab or adalimumab for a minimum of three months were included in this retrospective cohort study conducted from 1999 to December 2012. All required variables were collected from our electronic medical records (EMR) and paper charts. Drug survival was compared between these three TNF-α inhibitors with or without use of concomitant methotrexate by Kaplan-Meier plots. Box-plot analysis was carried out to understand dosing pattern of infliximab in the form of initial maintenance dose and any dose escalation. <h3>Results</h3> 183 etanercept, 60 infliximab and 54 adalimumab treated RA patients were included in this analysis. 75.4% etanercept treated patients remained on treatment whereas 51.7% and 48.1% in infliximab and adalimumab group respectively remained on treatment at the study conclusion. Secondary failures were reported 38.9%, 28.3% and 18.6% in adalimumab, infliximab and etanercept group respectively. Median drug survival rate of etanercept was higher compared to infliximab (43 months) and adalimumab (46 months) when used with concomitant methotrexate and infliximab (15 months), adalimumab (23 months) when used without concomitant methotrexate. 40% patients in the infliximab group required dose escalation to 5.31±1.38 mg/kg. Of these, majority (73.3%) patients required infliximab at every 6 week intervals. <h3>Conclusions</h3> In this study of real-world clinical practice, etanercept had the longest drug survival rate. Infliximab had the lowest drug durability. Further, we also confirmed lower drug survival of infliximab and adalimumab when used without methotrexate. Majority of infliximab patients beginning treatment with infliximab had their frequency of infusions and/or dose increased within the first 12 months. These three drugs didn't report any unexpected safety concerns. <h3>Disclosure of Interest</h3> A. Chow Grant/research support from: Abbot, Amgen, BMS, Janssen, Lilly, Roche, E. Soucy: None Declared, A. Shah: None Declared, M. Got: None Declared
SAT0346 Simultaneous assessment of bone loss in rheumatoid arthritis using peripheral quantitative CT and DEXA
Authors: B. Juhász, K. Gulyás, Ά. Horváth, E. Balogh, C. Horváth, H.P. Bhattoa, Z. Szekanecz
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) has been associated with secondary bone loss leading to osteoporosis in 60-70% of patients. Bone loss involves both the trabecular and cortical compartment. Traditional DEXA is not sufficient to assess bone loss in various compartments, however peripheral quantitative CT (pqCT) is. <h3>Objectives</h3> Simultaneous assessment of bone density was performed using DEXA and pqCT. Bone assessments were correlated with clinical parameters and ACPA status. <h3>Methods</h3> pqCT assessment was performed by a Stratec XCT-2000 instrument. Altogether 48 RA female patients and 10 female healthy controls were recruited. Forearm pqCT, as well as lumbar spine and femoral neck DEXA assessments were performed. Anti-CCP was determined by a second generation ELISA. <h3>Results</h3> The mean age of patients was 53.6±13.8 years and the mean disease duration was 13.5 years. Altogether 75% of patients were anti-CCP positive. In RA, total, cortical and trabecular attenuation, as well as bone density were decreased compared to controls as determined by pqCT (p&lt;0.005). Total and cortical pqCT density exerted inverse correlation with age, while total, cortical and trabecular pqCT showed positive correlation with lumbar and femoral neck BMD as determined by DEXA (p&lt;0.05). Trabecular, but not cortical pqCT density inversely correlated with anti-CCP positivity (p=0.04). <h3>Conclusions</h3> In RA, pqCT revealed cortical and trabecular bone loss. Moreover, anti-CCP, a marker of autoimmunity and a prognostic factor associated with joint erosions, also correlate with trabecular osteoporosis. In RA, as well as primary osteoporosis, pqCT may be a useful tool to assess trabecular and cortical bone loss. <h3>Disclosure of Interest</h3> None Declared
Abstract 4789: Human papillomavirus genotyping in urine samples of women with squamous intraepithelial lesions of cervix.
Authors: Tamara Viscarra, Alejandra Andana, Priscilla Brebi, Doris Menzel, Carmen G. Ili, Ramon Silva, Juan C. Roa, Raul Sanchez
Journal: Cancer Research (2013)

Abstract Human papillomavirus (HPV) is the most frequent microorganism sexually transmitted and is the causal agent of cervical carcinoma were it could be found in 99.7% of cases. The detection of HPV en women with or without lesions of cervix is generally performed in biopsies and cytobrush, which are invasive samples; therefore many patients do not attend to health care to get HPV test. The aim of this study was to develop a technique capable of detect and genotype HPV in urine samples of women with squamous intraepithelial lesions of cervix. For this study, 87 urine samples from patients with normal epithelia of cervix (25), low grade squamous intraepithelial lesion (LSIL) (24), high grade squamous intraepithelial lesion (HSIL) (38) were collected from women who attended to gynecological care in a public health center in Temuco, Chile. DNA extraction was performed with a manual method. For protein precipitation, Phenol-Chloroform and ammonium acetate were used. DNA precipitation was performed with absolute ethanol. HPV detection and genotyping was performed with the kit HPV Typing (patent pending) which is capable of detect 18 more frequent HPV types and beta globin gen as control of DNA integrity. 20% of urines from normal epithelia women were positive for HPV. Three genotypes were found in normal samples: HPV52, HPV42 and HPV53. LSIL there was a 92% of HPV positivity and the most frequent genotypes were HPV16 and HPV18. In HSIL, 95% of urine sample were positive for HPV. HPV16, HPV18 and HPV31 were the most frequent genotypes in HSIL. Genotypes found in urine samples were similar to world reports. Using the DNA extraction described before and HPV easy typing kit it is possible to detect and genotype HPV in urine samples. These results suggest that is possible a HPV primary screening test in non-invasive sample, complementing PAP smear in order to determinate which women have a higher risk of developing preneoplastic and neoplastics lesions. Grant Support: Proyect CORFO N° 09CN14-5960 (CEGIN). CI is recipient of grants from FONDECYT Postdoctoral Proyect N° 3130630. PB is recipient of grants from FONDECYT Postdoctoral Proyect N° 3120141. Citation Format: Tamara Viscarra, Alejandra Andana, Priscilla Brebi, Doris Menzel, Carmen G. Ili, Ramon Silva, Juan C. Roa, Raul Sanchez. Human papillomavirus genotyping in urine samples of women with squamous intraepithelial lesions of cervix. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4789. doi:10.1158/1538-7445.AM2013-4789
Limitations of the Usefulness of the Limulus Assay for Endotoxin
Authors: Russell J. Stumacher, Marilyn J. Kovnat, William R. McCabe
Journal: New England Journal of Medicine (1973)

Gelation of lysates of amebocytes of the horseshoe crab has been proposed as a highly sensitive and specific bioassay for endotoxin that might be of diagnostic value in infections due to gram-negative bacteria. To assess the diagnostic value of the test and evaluate the role of endotoxin in such infections, limulus assays were performed on 694 specimens collected during 344 episodes of suspected bacteremia and compared with qualitative and quantitative blood cultures. Positive assays were obtained from 28 of 65 patients (43 per cent) with bacteremia due to gram-negative bacilli and in 11 of 43 patients (26 per cent) with localized infections due to gram-negative organisms. However, the occurrence of positive assays in eight of 22 patients (36 per cent) with infections due to gram-positive bacteria, who had no concomitant infections with gram-negative organisms, casts doubt on the diagnostic value of the assay. In addition, no correlation was found between positive assays and the number of circulating gram-negative bacilli or the occurrence of shock or death. (N Engl J Med 288:1261–1264, 1973)
Monotonous tasks require self-control because they interfere with endogenous reward
Authors: George Ainslie
Journal: Behavioral and Brain Sciences (2013)

Abstract Self-control is a necessary component of subjective effort, but it depends only on farsighted motivation, with no additional, depletable resource. The aversiveness of boring tasks probably comes from their interference with endogenous reward, a new and potentially controversial concept. The self-control needed to stick with any kind of aversive experience increases as the values of the competing motives draw closer together.
AB0533 Lupusqol and Associations with Clinical Measurements of 104 Russian Patients with Lupus (Renaissance):
Authors: M. Zavalskaya, E. Asseeva, S. Soloviev, V. Amirdzhanova, S. Glukhova, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Methods</h3> A group of 104 SLE inpatients completed the LupusQoL. Demographic (age, sex, marital status,) and clinical variables (disease duration, disease activity, damage) were recorded. Associations between the 8 LupusQoL domains and age, disease duration, disease activity (SELENA SLEDAI), PGA and damage (SLICC/ACR DaI), sex and marital status were explored using Spearman9s correlation coefficients. <h3>Results</h3> HRQOL was assessed by 8 scales, poor = 0, good = 100 points. All domains of LupusQoL were impaired, with burden to others (58.9) being the worst affected and intimate relationship (73.5) the least. The correlations between the LupusQoL domain scores and age (r = -0.03 to -0.21) and disease duration (r= -0.19 to 0.4) were absent or weak. Similarly, there were no significant differences in the LupusQoL scores regarding sex, marital status. Although there were statistically significant correlations between the scores of the LupusQoL domains and of the SELENA SLEDAI (r= -0.28 to -0.12), the SLICC/ACR DAI (r= -0.36 to -0.23), these were weak of the PGA (r= -0.33 to -0.21). In our study low levels HRQOL &lt;40 (LupusQol), was associated with the presence of neuropsychiatric systemic lupus erythematosus (NPSLE) lesions (21%), p&lt;0.05, joints lesions (27.27%), p=0.27, skin lesions, rarely in patients with lupus nephritis (9.09%), p&lt;0.05. <h3>Conclusions</h3> HRQOL was impaired in our cohort of patients with SLE as assessed by the validated lupus-specific LupusQoL. There were no clinically important associations between the 8 domains of the LupusQoL and demographic variables in the Russian cohort. There were statistically significant correlations between the HRQOL and disease activity, and organ damage in Lupus patient. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4885
CLINICAL CHARACTERISTICS AND DETERMINANTS OF EXERCISE-INDUCED PULMONARY HYPERTENSION IN PATIENTS WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION
Authors: A. Young Lim, Suyeon Lee, Juwon Kim, Chunghun Kim, Sung-Ji Park, Jin-Oh Choi, Sang-Chol Lee, Seung Woo Park
Journal: Journal of the American College of Cardiology (2016)
Oral Administration of a Potent Carbonic Anhydrase Inhibitor (Diamox)
Authors: Alexander Leaf, William B. Schwartz, Arnold S. Relman
Journal: New England Journal of Medicine (1954)

THE dependence of renal acidifying mechanisms on the carbonic anhydrase in the renal tubules is well recognized.1 The role of this enzyme in acidification of the urine, as well as its function in the production of acid and alkaline secretions in other organs such as the stomach and the pancreas, depends on the catalysis of the reversible reaction: H2O + CO2 = H2CO3.2 In 1940 Mann and Keilin3 discovered that sulfanilamide and other unsubstituted sulfonamides inhibit carbonic anhydrase activity, and subsequently the inhibition of urinary acidification by these compounds was demonstrated.4 , 5 Even before . . .
Studies in Protein-Calorie Malnutrition
Authors: Joan L. Caddell, Daniel R. Goddard
Journal: New England Journal of Medicine (1967)

MAGNESIUM deficiency is a recognized problem in protein-calorie malnutrition of childhood,1 2 3 a complex nutritional-deficiency syndrome prevalent in many regions of the tropics that is thought to be largely responsible for an estimated 21 per cent mortality in Nigerian children one to four years of age.4 A small pilot study was conducted to assess biochemically the degree of magnesium deficiency in severely malnourished Nigerian children receiving care at the children's emergency service, the University College Hospital in Ibadan, Nigeria from mid-March until June, 1964.MethodsPatientsTwenty-eight children with serious malnourishment between one and four years of age (mean, three and . . .
Abnormal Bone Scan in Osteopoikilosis
Authors: SURJIT S. WADHWA, ROBERT MANSBERG
Journal: Clinical Nuclear Medicine (1999)

Osteopoikilosis is a sclerosing dysplasia of bone characterized by the development of multiple bone islands clustered near the articular ends of a bone. Typically patients are asymptomatic, although as many as 20% may have mild articular pain and effusion. Clinically osteopoikilosis must be distinguished from more severe dysplasias, such as tuberous sclerosis, mastocytosis, and, most importantly, osteoblastic metastatic lesions. Typically, findings of bone scans are normal in osteopoikilosis, and this feature has sometimes been used to differentiate it from metastatic bone disease. The authors present a case of osteopoikilosis with classic radiographic findings and an abnormal result of the bone scan.
RT-19 * PROGNOSTIC VALUE OF EARLY CHANGES IN NEUTROPHIL AND LYMPHOCYTE MEASURES DURING CHEMORADIOTHERAPY FOR GLIOBLASTOMA
Authors: M. Mason, M. McNamara, M. Tieu, Z. Lwin, B. A. Millar, C. Menard, N. Lapperiere, M. Milosevic, W. Mason, C. Chung
Journal: Neuro-Oncology (2014)

OBJECTIVES: Elevated baseline neutrophil-lymphocyte ratio (NLR) has been associated with worse outcome in various cancers, including glioblastoma (GBM). This retrospective study assesses if change in NLR during focal radiotherapy (RT) with Temozolomide (TMZ) for newly diagnosed GBM predicts outcome. METHODS: Patients treated with concurrent RT and TMZ for newly diagnosed GBM, between January 2004 and September 2010 were included. Age, ECOG performance status (ECOG-PS), dexamethasone dose, extent of surgery, tumor volume, neutrophil and lymphocyte counts (from baseline to 10 weeks) were collected. Statistical analysis included Kaplan Meier analysis and cox proportional hazard models with univariate (UVA) and multivariable (MVA) analyses. RESULTS: A total of 394 patients with median age of 54 (range 18-73) and median follow up 15.2 months (range 1.6-134.6) were analyzed. Median survival was 15.3 months (95% CI 14.3-16.9 months). Median baseline dexamethasone dose was 8mg (0-30mg) and median time-weighted mean dexamethasone dose (TWMdex) was 4.94mg (0.0 -27.4mg). On UVA, older age (HR 1.034, p<0.0001) and ECOG-PS>2 (HR 1.076, p < 0.001) were associated with shorter overall survival (OS). Baseline NLR below the median of 7.5 (HR 0.628, p < 0.0001) and decline in NLR (decNLR) (HR 0.644, p < 0.0001) were associated with better OS. On MVA, decNLR (HR 0.763, p = 0.02; CI 0.603 - 0.964), age (HR 1.032, p < 0.0001; CI 1.018-1.045), TWMdex (HR 1.039, p = 0.002; CI 1.014-1.065) and ECOG-PS (HR 0.593, p = 0.008; CI 0.403-0.873) remained prognostic for OS but not baseline NLR (HR 0.814, p = 0.09; CI 0.641 - 1.032). A low baseline NLR and further decrease in NLR predicted the longest survival (p < 0.0001). No significant linear correlation existed between tumor volume and baseline neutrophils (Rho =0.046, p = 0.42), lymphocytes (Rho = -0.015, p = 0.80) or NLR (Rho = 0.05, p = 0.40). CONCLUSIONS: Reduction in NLR during RT and TMZ for newly diagnosed GBM predicted for longer survival, even after accounting for steroid use.