tbuckley/cabot-search huggingface dataset:
The Hinge Region Regulates DNA Binding, Nuclear Translocation, and Transactivation of the Androgen Receptor
Authors: Annemie Haelens, Tamzin Tanner, Sarah Denayer, Leen Callewaert, Frank Claessens
Journal: Cancer Research (2007)

Abstract The androgen receptor (AR) encoding gene can undergo mutations during the development and treatment of prostate cancer. Even in hormone-independent stages, mutations in the receptor paradoxically seem to result in an increased AR function. Two such point mutations have been described in the part of the AR involved in DNA binding and nuclear translocation, namely the hinge region. Despite a decreased nuclear translocation, these mutant ARs display increased transactivating potencies. Through detailed analysis of the hinge region, we found that deletion of residues 629 to 636 resulted in a stronger androgen response on different reporters, although this mutant displays an extremely low in vitro affinity for androgen response elements. This superactivity is independent of nuclear localization and can be inhibited by antiandrogens. Surprisingly, the AR activation functions, AF1 and AF2, are not dramatically affected when the inhibitory region (629-RKLKKLGN-636) is deleted, although cotransfected p160 coactivator TIF2 had a stronger potentiating effect in the absence of this motif. The ligand-dependent interaction between the amino-terminal domain and the ligand-binding domain (N/C interaction) plays an important role in transactivation by the AR. We found that this interaction is strongly enhanced by deletion of the inhibitory region. In conclusion, the description of prostate cancer mutations has led to the discovery of a complex role of the hinge region in nuclear localization, DNA binding, coactivator recruitment, and N/C interaction of the AR. [Cancer Res 2007;67(9):4514–23]
Calcitonin gene related peptide inhibits basal, pentagastrin, histamine, and bethanecol stimulated gastric acid secretion.
Authors: H J Lenz, M T Mortrud, J E Rivier, M R Brown
Journal: Gut (1985)

This study was designed to examine the effect of calcitonin gene related peptide on gastric acid secretion in the rat. Calcitonin gene related peptide (1 pmol-1 nmol/rat) injected intravenously inhibited basal gastric acid secretion in awake, freely moving rats. Calcitonin gene related peptide decreased gastric secretion stimulated by histamine, pentagastrin, or bethanecol in anaesthetised rats. The inhibitory effect was immediate and most pronounced in the first hour and diminished during the second hour. The N- and C-terminal fragments of calcitonin gene related peptide, CGRP1-14 and [Tyr23]CGRP23-37, did not affect gastric acid secretion. [acetamidomethyl-cys2,7]CGRP, the linear cysteine-protected molecule devoid of the disulphide bridge, was not biologically active. After truncal vagotomy or atropine sulphate, calcitonin gene related peptide did not inhibit gastric secretion. These studies indicate that calcitonin gene related peptide administered peripherally inhibits basal and stimulated gastric acid secretion in the rat. Both C- and N-terminal residues as well as the disulphide bridge are necessary for the inhibitory effect on gastric secretion. Inhibition of gastric acid secretion by calcitonin gene related peptide may depend on intact vagal cholinergic fibres.
Erythema multiforme: demonstration of immune complexes in the sera and skin lesions
Authors: S. IMAMURA, K. YANASE, S. TANIGUCHI, S. OFUJI, L. MANGAOIL
Journal: British Journal of Dermatology (1980)

In twenty patients with erythema multiforme we investigated circulating immune complexes and their deposition in the skin lesions. CIq-binding activity was elevated in ten of twenty patients, and the platelet aggregation titre was high in three of twelve tested sera. Decreased levels of C3 were seen in two and of C4 in one out of eighteen patients. Direct immunofluorescence showed a deposition of C3, IgM or IgG in the blood vessel walls of the upper dermis in four of twelve patients. These findings may suggest that transient production of circulating immune complexes and their deposition play an important role in the pathogenesis of this disease.
Cryotherapy plus chemotherapy or radiation offers increased survival and quality of life in advanced stage lung cancer patients with endobronchial obstruction: Analysis of 160 patients treated with the rigid bronchoscope
Authors: Christos Chatziantoniou, Peter Michos, Ioannis Gakidis, Evangelos Sepsas, Athanasios Stamatelopoulos, Gerasimos Georgopoulos
Journal: European Respiratory Journal (2012)

Objective:  The objective of this clinical study is to evaluate the efficacy of Bronchoscopic Cryotherapy plus Chemotherapy or Radiation in quality of life and survival of non operable lung cancer patients with endobronchial obstruction.   Methods:  160 lung cancer patients with stage IIIa, IIIb, IV and endobronchial tumor, were included in a protocol of three sessions of rigid bronchoscopical cryotherapy. From 2001-2011 142 men (44-82 yrs old) and 18 women (45-66yrs old) were treated in our Department. After each cryotherapy one cycle of chemotherapy or radiation therapy followed. Patients age, sex, type of tumor, stage, symptoms of dyspnea, cough, hemoptysis, pain plus lung functional studies, performance status and survival time, were recorded. Follow up was at least two years.   Results  Symptoms of dyspnea, cough, hemoptysis and pain improved significantly in 73%, 68%, 69% and 42% of patients respectively(p  Survival increased considerably to 6-42 months (mean 16+) for stages IIIa, IIIb(Kaplan –Meier, 95% interval). We had 2(1.25%) in hospital deaths.   Conclusions:  Endobronchial Cryotherapy is a safe palliative method for inoperable lung cancer with endobronchial obstruction and combined with chemotherapy or radiation offers better survival and increased quality of life.
Polyunsaturated and Saturated Fat, Cholesterol, and Fatty Add Supplementation
Authors: Ahmed Kissebah, Gordon Schectman
Journal: Diabetes Care (1988)

Almost all of the risk factors for arteriosclerosis and coronary heart disease identified in population studies are overrepresented in diabetes. Of these risk factors, plasma lipids and lipoproteins are the target for altered dietary habits, particularly regarding fat. Such an alteration must be qualified with an understanding of the relationship between diabetes mellitus and lipoprotein metabolism and evidence of a favorable outcome of a fat-modified diet on this relationship. In seeking a revision of the current dietary fat recommendations of the American Diabetes Association, we have addressed five major questions. Is the serum lipid or lipoprotein concentration in diabetes different from that of the nondiabetic population? Are the familial or genetic forms of hyperlipidemia coinherited and/or overrepresented in diabetic subjects? What is the mechanism of the lipid/lipoprotein disorder in diabetes, and to what extent could it be related to the diabetic metabolic milieu? What is the effect of antidiabetic treatment on plasma lipids and lipoprotein metabolism? What evidence is there that a modified-fat diet could exert favorable benefits over and above what could be achieved by optimal antidiabetic therapy? This article outlines the revised dietary fat recommendations of the American Diabetes Association Nutrition Task Force and their rationale.
New kids on the block: pancreatic stellate cells enter the fibrogenesis world
Authors: M PINZANI
Journal: Gut (1999)

See article on page 534 

Two recently published papers have shown that a cell type with morphological features of “vitamin A storing” stellate cells is present in rat and human pancreatic tissue.1 2 These observations add to previous reports addressing the same issue in several other extrahepatic organs, including the lung, the intestine, and the kidney.3 4 

Over the past 10 years, a great deal of scientific information has followed the identification of stellate cells as the main cell type involved in the progression of liver fibrosis following chronic tissue damage.5 Several roles for this cell type in normal and diseased liver have been highlighted. In addition to storage of vitamin A, these include: (1) excessive deposition of extracellular matrix on activation; (2) modulation of sinusoidal tone in normal liver as a result of their contractile features and possible involvement in the progression of portal hypertension; (3) synthesis of soluble factors affecting liver …
New Boundaries for Complement in Renal Disease
Authors: Steven Sacks, Wuding Zhou
Journal: Journal of the American Society of Nephrology (2008)

Complement is an important component of the innate immune system whose function is integrated with the adaptive immune response. Since complement proteins are produced in virtually any cell in the body, it is important to question which pools of complement are responsible for what actions. This is particularly so in the case of complement-mediated renal disease, where distinct sites may require individualized approaches for therapy. From experimental and clinical evidence to date, it seems that the circulating pool of complement underlies much of the pathology traditionally associated with glomerular disease, including capillary wall injury. In contrast, the renal tubulointerstitium is the domain of local synthesis of complement, notably the axial component C3, principally expressed by the tubular epithelium. This means that therapeutic targeting will have to ensure penetration of the interstitial space in certain disorders. Likewise, monitoring of disease activity may benefit from evaluating this extravascular pool. Therapeutic and diagnostic applications in human disease are already taking this into account, with transplantation leading the way.
Selected clinical highlights from the 2010 ERS Congress in Barcelona
Authors: C. Robalo Cordeiro, S. Singh, F.J.F. Herth, S. Ley, N.H. Chavannes, E. Clini, V. Cottin
Journal: European Respiratory Journal (2011)

This article reviews a selection of presentations at the 2010 annual meeting of the European Respiratory Society held in Barcelona, Spain, which was the largest congress ever in the field of respiratory medicine. The best abstracts from the groups of the Clinical Assembly (Clinical Problems, Rehabilitation and Chronic Care, Imaging, Interventional Pulmonology, Diffuse Parenchymal Lung Disease, and General Practice and Primary Care) are presented in the context of the current literature.
Preobesity in World Health Organization Classification Involves the Metabolic Syndrome in Japanese
Authors: Tsuguhito Ota, Toshinari Takamura, Nobuyuki Hirai, Ken-ichi Kobayashi
Journal: Diabetes Care (2002)

Obesity has increased at an alarming rate throughout the world and has been regarded as a global epidemic disease in light of its close association with a cluster of cardiovascular risk factors, including hypertension, dyslipidemia, and hyperglycemia. This clustering of metabolic disorders is known as the metabolic syndrome, which is associated with insulin resistance (1). BMI is an estimate of total body fat mass and is probably the most useful scale to define obesity. Obesity has been defined as a BMI >30.0 kg/m2 in World Health Organization (WHO) classification (2), but this does not take into account the morbidity and mortality associated with more modest degrees of overweight. A significant increase in risk of death from cardiovascular disease was found for all BMIs of >25.0 kg/m2 in women and >26.5 kg/m2 in men in a prospective study conducted in the U.S. (3). The relation between BMI up …
Increased granulocytic, erythrocytic, and megakaryocytic progenitors in myelofibrosis with myeloid metaplasia
Authors: G. Chikkappa, A. L. Carsten, A. D. Chanana, P. Chandra, E. P. Cronkite
Journal: American Journal of Hematology (1978)

Abstract Nucleated cells obtained from blood and/or bone marrow of patients with myelofibrosis with myeloid metaplasia (MMM) were cultured in diffusion chambers (DC) implanted into the peritoneal cavities of irradiated mice. A total of five blood studies and two bone marrow studies were performed using cells obtained from five patients. The DC were harvested at intervals from the host mice and the total and differential cellularity of DC contents were evaluated. The results obtained from MMM cultures were compared with those from similar cultures of blood cells and marrow cells of four and six normal individuals respectively. The proliferation and maturation of the granulocytic, erythrocytic, and megakaryocytic lines in MMM cultures occurred in an orderly fashion as they occur in vivo. The patterns of proliferation and maturation of the three cell lines in cultures after day 7 suggest that they primarily originate from progenitor cells. The numbers of granulocytes in the multiplicative pool, recognizable red cell precursors, and megakaryocytes recovered were significantly greater from the MMM cultures than those from the normal blood or marrow cultures. These results suggest that the blood and marrow cells of MMM patients have increased numbers of progenitors for granulocytes, erythrocytes, and megakaryocytes.
Angiographic Appraisal of Distal Vessel Suitability for Aortocoronary Bypass Graft Surgery
Authors: JOSEF RÖSCH, CHARLES T. DOTTER, RUZA ANTONOVIC, LAWRENCE BONCHEK, ALBERT STARR
Journal: Circulation (1973)

The accuracy of preoperative coronary arteriography in determining distal vessel operability was evaluated in 166 patients studied arteriographically before and after bypass surgery. Appraisal accuracy correlated closely with the type of distal vessel filling, being highest (97%) in poststenotic vessels with antegrade filling; lower (76%) beyond occlusions with generous retrograde collateral flow; and least (65%) in postocclusion vessels filled by insufficient collaterals. Optimum data collection is favored by the use of high-definition serial roentgenography with extended filming in multiple projections; competent interpretation requires the integrated assessment of interdependent variables, including distal vessel morphology, filling patterns, branch disease, run-off capacity, and myocardial status.
VITILIGO AND BLOOD GROUPS..
Authors: GURMOHAN SINGH, PRAKASH SHANKER
Journal: British Journal of Dermatology (1966)

Journal Article VITILIGO AND BLOOD GROUPS.: Preliminary Report. Get access GURMOHAN SINGH, M.D., GURMOHAN SINGH, M.D. The Skin and V.D. Section, Department of Medicine, College of Medical Sciences, Banaras Hindu University, Varanasi‐5, India Search for other works by this author on: Oxford Academic Google Scholar PRAKASH SHANKER, M.B., B.S. PRAKASH SHANKER, M.B., B.S. The Skin and V.D. Section, Department of Medicine, College of Medical Sciences, Banaras Hindu University, Varanasi‐5, India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 2, 1 February 1966, Pages 91–92, https://doi.org/10.1111/j.1365-2133.1966.tb12180.x Published: 01 February 1966
The autoclavable semirigid thoracoscope: the way forward in pleural disease?
Authors: M. Munavvar, M. A. I. Khan, J. Edwards, Z. Waqaruddin, J. Mills
Journal: European Respiratory Journal (2007)

Medical thoracoscopy is a valuable tool in the investigation and management of pleural disease. It has considerable advantages over conventional blind pleural biopsy and video-assisted thoracoscopic surgery. Despite this, the practice of this technique in the UK is limited. Most operators use the rigid thoracoscope, which may be an unfamiliar instrument to respiratory physicians. A semirigid thoracoscope is available but its use has not been possible in the UK as it requires sterilisation with ethylene oxide, which is not approved in this country. The present authors describe herein their experience with the first ever autoclavable semirigid thoracoscope. Medical thoracoscopy using the new instrument was performed in 56 patients between June 2004 and May 2006. All patients had been referred with a unilateral pleural effusion of unknown aetiology, where blind pleural aspiration had failed to yield an answer. Diagnostic samples were taken and talc poudrage performed where appropriate. The instrument was easy to handle and excellent views were obtained. Histologically adequate biopsy samples were obtained in 54 patients. The combination of clinical features, computed tomography findings and thoracoscopic biopsy enabled a definite diagnosis in 49 (90.7%) of these patients. There were no complications. The autoclavable semirigid thoracoscope has immense potential in the diagnosis and management of pleural disease. Its diagnostic yield in pleural disease is comparable to the conventional rigid thoracoscope. It is similar in design to the fibreoptic bronchoscope and respiratory physicians should be able to adapt to its use easily. It is also compatible with existing video processors and light sources available in most endoscopy suites. The fact that this instrument is autoclavable should open the field for its use in the UK as well as in other countries.
Role of Right Atrial Endocardial Structures as Barriers to Conduction During Human Type I Atrial Flutter
Authors: Jeffrey E. Olgin, Jonathan M. Kalman, Adam P. Fitzpatrick, Michael D. Lesh
Journal: Circulation (1995)

The importance of barriers in atrial flutter has been demonstrated in animals. We used activation and entrainment mapping, guided by intracardiac echocardiography (ICE), to determine whether the crista terminalis (CT) and eustachian ridge (ER) are barriers to conduction during typical atrial flutter in humans.In eight patients, ICE was used to guide the placement of 20-pole and octapolar catheters along the CT and interatrial septum and a roving catheter to nine sites: just posterior (1) and anterior (2) to the CT along the lateral right atrium, at the fossa ovalis (3), and just posterior and anterior to the ER at the low posterolateral (4 and 5), low posterior (6 and 7), and low posteromedial (8 and 9) right atrium. Entrainment was performed, and each site was considered within the flutter circuit if the postpacing interval-flutter cycle length (PPI-FCL) and the stimulus time-activation time (stim time-act time) were < 10 msec. Split potentials were recorded along the CT with components activated in a low-to-high pattern and a high-to-low pattern. Conduction times, as percentage of FCL, were significantly different at sites on either side of the CT and ER: site 1 (33 +/- 13%) and site 2 (43 +/- 12%) (P = .02), site 4 (48 +/- 24%) and site 5 (75 +/- 8.9%) (P = .02), and site 6 (22 +/- 10%) and site 7 (82 +/- 5.3%) (P = .0009). During entrainment, no surface fusion was observed at sites 5, 7, or 9. The PPI-FCL and stim time-act time were not significantly different than 0 at sites 2, 7, 5, or 9, indicating that they were within the flutter circuit, whereas sites 1, 3, 4, and 6 were not.ICE enabled the correlation of functional electrophysiological properties with specific anatomic landmarks, identifying the CT and ER as barriers to conduction during human atrial flutter.
A verruciform xanthoma-like phenomenon in a linear epidermal naevus in the absence of a syndromic association
Authors: J.Y. Ko, H. Shin, C.W. Lee
Journal: British Journal of Dermatology (2008)

Journal Article A verruciform xanthoma‐like phenomenon in a linear epidermal naevus in the absence of a syndromic association Get access J.Y. Ko, J.Y. Ko Department of Dermatology, Hanyang University Hospital, Seoul, Korea E‐mail: drko315@hmc.hanyang.ac.kr Search for other works by this author on: Oxford Academic Google Scholar H. Shin, H. Shin Department of Dermatology, Hanyang University Hospital, Seoul, Korea E‐mail: drko315@hmc.hanyang.ac.kr Search for other works by this author on: Oxford Academic Google Scholar C.W. Lee C.W. Lee Department of Dermatology, Hanyang University Hospital, Seoul, Korea E‐mail: drko315@hmc.hanyang.ac.kr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 2, 1 August 2008, Pages 493–496, https://doi.org/10.1111/j.1365-2133.2008.08661.x Published: 01 August 2008
A rare mutation [IVS-I-130 (G-A)] in a Turkish ?-thalassemia major patient
Authors: G.O. Tadmouri, O. Bileno?lu, S. Kantarc?, H. Kayserili, P. Perrin, A.N. Ba?ak
Journal: American Journal of Hematology (2000)

Here we describe the identification of the rare β-thalassemia mutation IVS-I-130 (G-A) for the first time in Turkey. The hematological evaluation of the patient showed classical signs of β-thalassemia major requiring regular blood transfusions every 30–35 days. DNA analysis was carried out using reverse dot-blot hybridization and restriction endonuclease digestion, as well as genomic sequencing. The patient was found to be heterozygous for the IVS-I-6 (T-C) and IVS-I-130 (G-A) mutations. In order to deduce a possible origin for the IVS-I-130 (G-A) mutation, the sequence polymorphisms in the DNA of the patient and her family were characterized. The method included the analysis of nine polymorphic nucleotides and the hypervariable microsatellite of composite sequence (AT)xTy 5′ to the β-globin gene by DNA sequencing. The sequence haplotype (HT4) carrying the IVS-I-130 (G-A) mutation is also observed in Algeria. This favors a Northeastern African origin for this allele. The observed results agree well with a recent introduction of this mutation to Turkey from Egypt toward the end of the 19th century. Am. J. Hematol. 63:223–225, 2000. © 2000 Wiley-Liss, Inc.
Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 study
Authors: Sylvain Choquet, Veronique Leblond, Raoul Herbrecht, Gérard Socié, Anne-Marie Stoppa, Peter Vandenberghe, Alain Fischer, Franck Morschhauser, Gilles A. Salles, Walter Feremans, Etienne Vilmer, Marie-Noelle Peraldi, Philippe Lang, Yvon Lebranchu, Eric Oksenhendler, Jeanne Luce Garnier, Thierry Lamy, Arnaud Jaccard, Augustin Ferrant, Fritz Offner, Olivier Hermine, Anne Moreau, Samira Fafi-Kremer, Patrice Morand, Lucienne Chatenoud, Nathalie Berriot-Varoqueaux, Loïc Bergougnoux, Noel Milpied
Journal: Blood (2005)
The Panspecific Hemopoietin of Activated T Lymphocytes (Interleukin-3)
Authors: J W Schrader
Journal: Annual Review of Immunology (1986)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Response to Idelalisib in a Patient with Stage IV Merkel-Cell Carcinoma
Authors: Mallory B Shiver, Fade Mahmoud, Ling Gao
Journal: New England Journal of Medicine (2015)

thal et al. cite also states that CMS payments to participating clinics totaled $20 per beneficiary per month. 2 Similarly, bonus payments from CMS to MSSP ACOs raised Medicare spending by 0.7% in the program's first year, while the ACOs saved Medicare 0.5%, for a net increase in spending of 0.2%. 3