tbuckley/cabot-search huggingface dataset:
SP0107 Education, monitoring and outcome in providers of a self-regulation program to increase physical activity in rheumatoid arthritis
Authors: I. Demmelmaier
Journal: Annals of the Rheumatic Diseases (2013)

There are at least two obvious purposes to study providers of behavior change interventions; 1) to assess treatment integrity, i.e. to what degree the intervention was delivered as intended, and 2) to gain knowledge about effective implementation methods, i.e. how education of providers should be designed to match what they are supposed to deliver. This presentation focuses on the second purpose. Promoting physical activity behavior in patients requires providers that are skilled to guide in self-regulatory techniques such as realistic goal-setting and self-monitoring. In 2010 we launched a two-year program to implement health-enhancing physical activity in persons with rheumatoid arthritis (RA). During the first year, twelve physiotherapists ("physio coaches") guided the participants to increased physical activity using their everyday environment as well as public gyms and regular support group meetings. The education comprised two times two days before the intervention and two one-day "booster sessions" during the first year of the intervention. We trained the physio coaches according to crucial concepts in Social Cognitive Theory focusing on self-efficacy for coaching, feed-back on performance, and observational learning. Their <i>self-efficacy</i> was promoted by identifying challenging coaching situations, discussing ways to manage them and practicing in role-plays. Individual home assignments were formulated to enable further practice. Individual <i>feed-back</i><i>on performance</i> was given to each coach by one researcher after observing coaching sessions twice; at the beginning and towards the end of the first intervention year. These sessions were video-recorded and sequences with good examples of coaching were published at an Internet site available only for the coaches. In this way, <i>observational learning</i> was enabled by watching colleagues performing well. The education is evaluated by assessing the coaches' knowledge, attitudes and self-efficacy for coaching before, during and after the education. Coaching behavior is assessed by self-reports in logs and by analyzing the video recordings according to predefined criteria. Interviews are performed to further investigate the physio coaches' experiences during the first year of the intervention. <h3>Disclosure of Interest</h3> None Declared
PARE0006 Move and improve initiative in lithuanian arthritis association
Authors: O. Telyceniene, J. Dadoniene
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Lot of attention is paid to physical activities initiatives carried out in our organization. Some of them are state supported while others come from initiative of organization members. <h3>Results</h3> There are number of ways to be physically active despite of age or disease. This initiative is supported by governmental organizations through the projects already for five years in a row. The aim of the government supported projects is to give the opportunity for every member of the organization for rehabilitation course in professionally supervised groups. The majority of our branch organizations take this opportunity at least two times per year, in spring and in autumn time. The groups carry their activities outside or inside, in gyms or in water pools. The professional rehabilitation specialists usually supervise the groups. The members of our organizations are also active in developing ideas themselves, like learning yoga exercises through internet based programmers or Nordic walking activities. Higher spirit and better mood are the reward for mental and physical efforts. Each year the LAA association is organizing the Health campus at the Baltic sea where the delegates from each branch organization get together. The last year the health campus was organized already for eleventh year. The duration of our campus is usually 10 days. It brings together people of different interests and physical capabilities but they are united by one idea to improve their health by being together. EULAR initiative "Move and improve" was strongly supported by the members of our organization. This was a slogan of the autumn conference held on October the 12. The lecturers and participants acknowledged that moving is the best way to stay in health and active in daily living. This year the conference hosted almost 350 hundred people meaning much more participants than the year ago. Not only the lectures were interesting to the participants but also the physical exercises during the interruptions. It made the people feel better and more enthusiastic during the whole event. The printed material about rheumatic symptoms and how to care about joints are issued every year. The magazine "Artritas" is issued quarterly and distributed to every branch organiztion. The best examples of community activities are described and may be forwarded to others. <h3>Conclusions</h3> The Lithuanian arthritis association has a long standing traditions in helping their members to be physically active. The financial help coming from governental resources is essemtial but the understanding and williness to participate in these activities is equally important. <h3>Disclosure of Interest</h3> None Declared
Frequent allelic loss of the BCL10 gene in lymphomas with the t(11;14)(q13;q32)
Authors: D Steinemann, R Siebert, S Harder, I Martin-Subero, G Kettwig, B Hinzmann, S Gesk, M Tiemann, H Merz, A Rosenthal, W Grote, SW Morris, B Schlegelberger
Journal: Leukemia (2001)
FRI0008 IL-21 regulates B cell proliferation and differentiation in rheumatoid arthritis
Authors: R. Liu, Q. Wu, X. Li, L. Sun
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Interleukin (IL)-21 is a member of type I cytokine family. Recent studies have indicated that IL-21 is an important regulator for human B cell activation, proliferation, plasma cell (PC) differentiation, immunoglobulin (Ig) production and isotype switching. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by abnormal production of cytokines and autoantibodies including rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP), suggesting that B cells play a key role in pathogenesis of RA. <h3>Objectives</h3> The aim of this study was to investigate the effect of IL-21 on B cell proliferation and differentiation of RA patients. <h3>Methods</h3> Concentrations of IL-21 in serum were measured by ELISA. The correlation between serum IL-21 levels and clinical features of RA patients were assessed. The percentages of IL-21R<sup>+</sup>CD19<sup>+</sup> cells were analyzed by flow cytometry (FACS) in peripheral blood mononuclear cells (PBMC) from RA patients and healthy controls. PBMC from RA patients were stimulated with rIL-21 (50 or 100ng/ml) after motivation of anti-CD40 and anti-IgM. The percentages of IL-21R, activation markers (CD40, CD69 and CD25) on B cells and the proliferation labeled with CFSE as well as differentiation of B cells were determined by using FACS analysis <h3>Results</h3> The results showed that serum IL-21 concentrations in RA patients (191.3±34.42pg/ml, n=104) were significantly higher than in healthy controls (10.33±11.43pg/ml, n=56, p&lt;0.01). The levels of IL-21 in RA patients were positively related to RF-IgM (r=0.23, p&lt;0.05), RF-IgA (r=0.34, p&lt;0.05), RF-IgG (r=0.35, p&lt;0.05) and anti-CCP (r=0.32, p&lt;0.05). Moreover, the percentages of IL-21R<sup>+</sup>CD19<sup>+</sup> cells were found to be markedly higher in PBMC of RA patients (48.55%±2.63%, n=50) compared to healthy controls (34.12%±2.37%, n=40, p&lt;0.01) and IL-21 could up-regulate IL-21R expression on B cells in vitro. Meanwhile, IL-21 stimulated the proliferation of B cells and activated markers expressions (CD40, CD69 and CD25). IL-21 induced more production of CD138<sup>+</sup>CD19<sup>+/low</sup> cells in RA patients, indicating that IL-21 can promote B cell differentiation. <h3>Conclusions</h3> These results suggest that increased IL-21 expression from RA patients might support B cells proliferation, activation and antibody secretion. Thus, antagonizing IL-21 may be a novel strategy for treating RA. <h3>Disclosure of Interest</h3> None Declared
Influence Of DNA Methyltransferese Inhibitors On The Anti-Leukemic Effect Of Umbilical Cord Blood Derived NK Cells Against Acute Myeloid Leukemia
Authors: Harry Dolstra, Jeannette Cany, Anniek B. van der Waart, Marleen Tordoir, Basav Nagaraj Hangalapura, Jan Spanholtz, Robbert van der Voort, Nicolaas PM Schaap
Journal: Blood (2013)
Endoscopic ultrasound guided percutaneous endoscopic gastrostomy for enteral feeding tube placement
Authors: Wang Zhiqiang, Chen Xiao, Fu Yonghe, Zhou Qing, Zhang Yu, Wang Ming, Zhang Ziqi
Journal: Endoscopy (2011)

Aim: To evaluate the feasibility and safety of Endoscopic ultrasound (EUS) guiding PEG (percutaneous endoscopic gastrostomy) in patients.
PATTERNS AND PREDICTORS OF STROKE VOLUME CHANGE WITH TRANSCATHETER AORTIC VALVE REPLACEMENT FOR LOW-GRADIENT AORTIC STENOSIS AND NORMAL EJECTION FRACTION
Authors: Paul Sorajja, Aisha Ahmed, Richard Bae, John Lesser, Wesley Pedersen, Lisa Tindell, Kevin Harris, Robert Farivar
Journal: Journal of the American College of Cardiology (2016)
Abstract P6-01-01: Risk of Invasive Breast Cancer and Ductal Carcinoma In-Situ in Women with Atypical Papillary Lesions of the Breast
Authors: KC Cuneo, RC Dash, LG Wilke, BF. Koontz
Journal: Cancer Research (2010)

Abstract Background: Benign papillary lesions of the breast including papilloma and papillomatosis are believed to be associated with a low risk of developing breast cancer. The risk of breast cancer development in patients who have an atypical papilloma or who have a papilloma in conjunction with atypical hyperplasia is not well defined. Methods: All patients who underwent a biopsy at Duke University Medical Center between October 1992 and December 2009 for a papillary lesion of the breast were identified. Patients were excluded if they had a previous or concurrent diagnosis of invasive or in-situ malignancy or less than 6 months of follow up. The remaining patients were analyzed to determine the risk of developing breast cancer. Results: Median follow up for the 167 patients with a papillary lesion of the breast included in the analysis was 4.6 years. 51 patients had an atypical papillary lesion. 111 patients had atypical hyperplasia in conjunction with a papilloma. 35 patients had a papilloma without atypia or atypical hyperplasia. Patients with an atypical papilloma were more likely to develop an invasive or in-situ breast cancer with a 5 year actuarial risk of 13.0% (24 patients at risk) versus 4.6% (49 patients at risk) (p=0.03). Patients who had atypical hyperplasia in conjunction with a papilloma were also more likely to develop invasive or in-situ breast cancer with a 5 year actuarial risk of 9.8% (48 patients at risk) versus 0% (15 patients at risk) (p=0.05). In the group with an atypical papillary lesion, the actuarial risk of ipsilateral breast cancer or DCIS development was 8.2% at 5 years (24 patients at risk) and 21.1% at 10 years (12 patients at risk). In the group with atypical hyperplasia in conjunction with a papilloma, the actuarial risk of ipsilateral breast cancer development was 3.9% at 5 years (48 patients at risk) and 8.5% at 10 years (18 patients at risk). The majority of patients underwent an excisional biopsy for their papilloma (150 patients). Patients who had a core needle biopsy alone had a 5 year actuarial risk of ipsilateral breast cancer or DCIS of 15.3% versus 2.0% for patients who had an excisional biopsy (p=0.03). All of the patients who had only a core biopsy and later developed an ipsilateral cancer or in-situ disease had an atypical papilloma. Discussion: Papillary lesions of the breast with atypical features may be associated with an increased risk of breast cancer and DCIS. Atypical papillary lesions should be fully excised or followed closely. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-01-01.
Immature I<sub>G</sub>A B Cells in I<sub>G</sub>A-Deficient Patients
Authors: Mary Ellen Conley, Max D. Cooper
Journal: New England Journal of Medicine (1981)

IN normal B-cell differentiation, the classes of surface immunoglobulin are acquired in a defined sequence. The earliest B cells bear surface IgM; as the cells mature they acquire surface IgD and sometimes IgA or IgG.1 In the normal newborn almost all the IgA and IgG B cells in the peripheral circulation concomitantly bear surface IgM and IgD. However, in the adult most of the IgA B cells can be brightly stained for IgA by immunofluorescence techniques, but are negative for surface IgM and IgD.1 , 2 These observations suggest that the cells bearing all three classes — IgM, IgD, and IgA — . . .
Molecular and Cellular Biology of Blood Coagulation
Authors: B Furie, B C Furie
Journal: New England Journal of Medicine (1992)

BLOOD clotting is a host defense mechanism that, in parallel with the inflammatory and repair responses, helps protect the integrity of the vascular system after tissue injury. This system is normally quiescent but becomes active within seconds after injury. Cells (platelets, leukocytes, and endothelial cells) and the plasma blood-clotting proteins are critical in this reaction. The response to vascular injury culminates in the formation of a platelet plug, the generation of a fibrin clot, the deposition of white cells in the area of tissue injury, and the initiation of inflammation and repair.Molecular Basis of Blood CoagulationAll the protein . . .
P88 Vascular adhesion protein-1 (VAP-1) modulates glucose and lipid uptake in Non-Alcoholic Fatty Liver Disease (NAFLD)
Authors: S. Karim, E. Liaskou, J. Youster, F.-L. Lim, K. MacAulay, S. Jalkanen, D. H. Adams, P. F. Lalor
Journal: Gut (2011)

<h3>Introduction</h3> NAFLD is characterised by steatosis, chronic inflammation and fibrosis. The underlying mechanisms include insulin resistance, increased free fatty acid flux from de-novo lipogenesis and decreased lipid oxidation. Vascular Adhesion Protein—1 (VAP -1), is an adhesion molecule with semicarbazide- sensitive amine oxidase activity (SSAO), which is also expressed as a soluble protein in serum (sVAP-1) and elevated in inflammatory liver diseases such as NAFLD. VAP-1 has been shown to modulate glucose and lipid uptake in muscle and adipose tissue and thus we investigated whether it may contribute to glucose and lipid homeostasis in human liver tissue. <h3>Method</h3> We have used precision cut liver slices (PCLS) from normal and diseased human liver specimens and cultured human sinusoidal endothelium (HSEC) and hepatocyte cells in combination with VAP-1 substrates (200 μM methylamine or benzylamine) and inhibitors (400 μM bromoethylamine) to perform standard ex vivo radiolabelled glucose uptake and fatty acid uptake assays using oil red O quantification following exposure of cells to Oleic and Palmitic acid (PA). Immunohistochemical staining and qPCR were performed using standard techniques and for confirmatory experiments HSEC were transfected with enzymatically active/inactive VAP1. <h3>Results</h3> QPCR confirmed upregulation of VAP-1 mRNA (ΔΔCT =1.144 p=0.03) in NASH vs normal liver and also changes in FABP1, -4, -5, FATP3, -4 (p≤0.05 for all) and GLUT-1, 2, 3, 5, 8, 9 and 12 in NAFLD compared to normal individuals. Results were confirmed using immunohistochemical staining. Exposure of human PCLS to sVAP-1 and methylamine typically resulted in a 38–54% increase in PA uptake (p≤0.01 for all) and a 20% increase in hepatocyte glucose uptake in vitro which could be inhibited using bromoethylamine. Transduction of HSEC with enzymatically active VAP-1 also increased glucose uptake which was prevented in the absence of enzyme activity. Interestingly methylamine treatment of human liver resulted in decreased expression of mRNA for glucose transporters and an increase in some lipid transporters including FABP6, FATP and LRP8, and H<sub>2</sub>O<sub>2</sub> produced by SSAO activity increase lipid uptake by hepatic cells. <h3>Conclusion</h3> In conclusion, we demonstrate for the first time global alterations in cellular expression of glucose and lipid transporter proteins in human NAFLD. We confirm that VAP-1 is elevated in disease and that SSAO activity of VAP-1 results in enhanced hepatic lipid and glucose uptake and changes in transporter expression. Thus we propose that bioactive metabolites of SSAO activity contribute to the metabolic derangement evident in fatty liver disease.
PTU-260 Are we working at a loss? Does routine coding for endoscopic retrograde cholangiopancreatography (ERCP) provide accurate remuneration?
Authors: V Jackson, L Siadankay, B Saleh, R Sturgess, N Stern
Journal: Gut (2012)

<h3>Introduction</h3> Endoscopic procedures in the UK are remunerated through “Payment by results” with a healthcare resource group (HRG) tariff assigned to each procedure. HRG tariffs depend on accurate coding of the diagnosis and procedure to enable appropriate payment from primary care trusts (PCT). There is little existing data about the accuracy of coding in ERCP to generate appropriate HRG tariffs. <h3>Methods</h3> Cases were randomly selected from those attending for ERCP at our unit between 24 March 2010 and 2 July 2010 with full information available. Each procedure was reviewed by a member of the hospitals coding department and a consultant gastroenterologist who regularly performs ERCP, with details of initial routine coding available. Cases were all re-coded following clinician input with subsequent re-calculation of HRG tariff. <h3>Results</h3> 39 cases were reviewed. 20 in-patient procedures and 19-day cases. This included 24 (61.5%) accurately coded and 15 (38.5%, 2-day cases and 7 in-patients) requiring re-coding. The re-coding was due to incorrect primary diagnostic code: 3; primary procedure code: 9; both codes: 3. Four of the procedure code changes resulted in increases to HRG tariffs. None of the re-coding led to a reduction in tariff. Three of these were due to incorrect coding of metal stent insertion and one due to omission of coding for sphincterotomy. The initial coding led to an income of £60 033 with the revised coding suggesting remuneration should have been £69 037: a shortfall of £9004. The single biggest shortfall was in the coding of “stent” insertion. Unless clearly labelled as “metal stent,” these were routinely coded as plastic stents which carry a lower tariff. <h3>Conclusion</h3> There is a difference in coding of ERCPs in 38.5% of procedures we studied. This led to over 10% re-coded to a higher HRG tariff, potentially increasing ERCP related income. Accurate coding is necessary to ensure appropriate remuneration for hospital trusts. Particular attention to the recording of insertion and coding of metallic stents is needed. <h3>Competing interests</h3> None declared. <h3>Reference</h3> 1. <b>Moar K</b>, Rogers S. Impact of coding errors on departmental income: an audit of coding of microvascular free tissue transfer cases using OPCS-4 in UK. <i>Br J Oral Maxillofac Surg</i> 2012;<b>50</b>:85–7.
THE UTILITY OF T-WAVE AMPLITUDE IN LEAD AVR ON THE CLINICAL DIAGNOSIS OF CARDIAC INVOLVEMENT IN PATIENTS WITH SARCOIDOSIS
Authors: Yoshihiro Tanaka, Tetsuo Konno, Shohei Yoshida, Toyonobu Tsuda, Kenshi Hayashi, Hiroshi Furusho, Masayuki Takamura, Masa-Aki Kawashiri, Masakazu Yamagishi
Journal: Journal of the American College of Cardiology (2016)
Screening an Asymptomatic Person for Genetic Risk — Polling Results
Authors: Joann Schulte, Carla S. Rothaus, Jonathan N. Adler, Elizabeth G. Phimister
Journal: New England Journal of Medicine (2014)

Genetic testing is evolving rapidly. The availability of genome and exome sequencing, combined with the availability of over-the-counter genetic testing kits for asymptomatic persons, is raising complex patient care issues. In June, we presented the case of Jim Mathis, a fictional asymptomatic 45-year-old man who was concerned about his risk for cancer and who asked his internist about genetic testing.1 Two experts in the field presented their views about . . .
Letters Re: "Cyclosiloxanes Produce Fatal Liver and Lung Damage in Mice"
Authors: Betsy D. Carlton, Robert G. Meeks, Hanspeter Witschi, Jerzy Lukasiak, Zygmunt Jamrogiewicz, Bogdan Falkiewicz, Gary J. Burin, Frank N. Dost
Journal: Environmental Health Perspectives (1999)
AB0337 Association of disease activity and sociodemographic characteristics with disability of patients with rheumatoid arthritis
Authors: S.R. Schwarzkopf, H. Kuhlow, A. Kutter, E. Grill
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid Arthritis (RA) is a chronic and disabling condition which affects activities of daily living and participation. To prevent or delay disability it is important to understand how disease activity relates to disability. <h3>Objectives</h3> To analyze the association of disease activity to disability in patients with RA. Specifically, we wanted to examine how sociodemographic characteristics modify this association. <h3>Methods</h3> Patients fulfilling the American College of Rheumatology classification criteria and presenting in our dedicated outpatient clinic were included consecutively between 2001 and 2005. Disease activity was measured with the Disease Activity Score (DAS) without (DAS3) and including questions on general health (DAS4). Disability was assessed with the Health Assessment Questionnaire (HAQ-DI). Additionally we collected data on age at diagnosis, education and household size. Associations were analysed with logistic regression models with the HAQ-DI score dichotomized at median as dependent variable. <h3>Results</h3> 122 patients were included, 79% were female, mean age was 56 years (SD 13), mean age at first diagnosis was 46 years, mean disease duration was 10 years (SD 10.9). Patients had a mean DAS3 of 3.5 and mean DAS4 of 3.8; mean HAQ-DI was 1.0 (SD =0.7; median 1.0). DAS3 and DAS4 were positively correlated with the HAQ-DI score (r =0.53, 0.56). Adjusted for age at diagnosis, sex, education and household size, the association between DAS3 and HAQ-DI summary score was still significant (OR =2.58, 95% confidence interval CI 1.71 to 3.88). Higher age at diagnosis and living alone were associated with lower risk for disability (OR =0.95 per year, 95% CI 0.92 to 0.99; OR =3.13 for living with others, 95% CI 1.10 to 8.93) while higher education was not (OR =0.75, 95% CI 0.21 to 2.72). <h3>Conclusions</h3> Disease activity was positively associated with disability as measured with the HAQ-DI. Higher age at diagnosis and living alone were associated with lower risk for disability. Our findings may allow identifying subpopulations at risk for poorer outcomes and thus improving patient care and outcomes in RA. <h3>Disclosure of Interest</h3> None Declared