tbuckley/cabot-search huggingface dataset:
Wisconsin Comorbidity Assessment Scale (WCAS): A novel, comprehensive, performance-based assessment scale of geriatric syndromes and medical comorbidities in older cancer patients
Authors: M. K. Krishnamachary, R. J. Swain-Eng, J. Barnet, J. Maloney, J. A. Stewart, S. Asthana
Journal: Journal of Clinical Oncology (2007)

19619 Background: Elderly patients with cancer have potential for multiple geriatric syndromes that influence treatment and outcomes. No single clinical assessment tool has targeted all the major geriatric syndromes and their interaction on cancer management and outcomes. We developed WCAS to evaluate cognitive and physical function, risk of falls and gait disorders, polypharmacy, and medical comorbidities. Methods: Eighteen newly diagnosed patients with breast cancer (age 55–82), were enrolled prior to cancer treatment. Cognitive function was evaluated with a comprehensive battery of neuropsychological tests targeting the domains of memory, executive function, attention, language, and praxis. Physical function skills were assessed with novel performance-based tasks (e.g., bed-making) and computerized assessments of balance, gait and risk of falls. Cancer treatment included surgery in all patients with variable use of adjuvant radiation and medical therapy. WCAS was administered at baseline and at month 6. Results: Ten subjects have completed both baseline and month 6 visits. Surgical treatment occurred at a mean of ten days after baseline assessment (SD 6.7). The mean (SD) of the age, years of education and baseline Mini Mental Status Exam (MMSE) was 66 years (7.3), 15.2 years (3.7) and 29.3 (1.1). From baseline to month six assessment performance on the WAIS Digit Symbol test, a measure of working memory and processing speed, declined (mean change −11.7, p&lt;0.01). Likewise, the performance on the WAIS letter number sequence test (mean change −1.3, p=0.09) and the MMSE (mean change −1.1, p=0.12) declined. Interestingly, four subjects with pre-existing hypothyroidism on replacement treatment showed a greater decline (p&lt;0.01) in memory than those without this common condition. Conclusions: Findings indicate that breast cancer diagnosis and therapy can be associated with significant decline in aspects of cognition in older adults with cancer. These changes can last at least 6 months and are more pronounced in those with hypothyroidism. Larger, longer term prospective studies utilizing WCAS are necessary to confirm our preliminary findings. No significant financial relationships to disclose.
An Oyster Neoplasm of Apparent Mesenchymal Origin
Authors: Martin W. Newman
Journal: JNCI Journal of the National Cancer Institute (1972)

A neoplastic disorder was found in 1 of 1,400 oysters (Crassostrea virginica) examined from an area near New Haven, Connecticut. The abnormally large atypical cells characterizing this disease were most abundant in the gill region. Additional neoplastic cells were in hemolymph vessels and sinuses and had invaded the vesicular connective tissue. Mitotic figures were common. Epithelium, muscle, and gonad were not invaded. This neoplasm differed cytologically from all previously described oyster neoplasms, but strongly resembled a neoplastic disease described from the mussel (Mytilus edulis) in Oregon.
Response of Chick-Embryo Kidney Cells In Vitro to Two Avian Tumor Viruses2
Authors: Robert A. Bonar, David F. Paulson
Journal: JNCI Journal of the National Cancer Institute (1974)

Treatment in vitro of chick-embryo kidney cells with strain MC29 avian tumor virus resulted, in 90% of the trials, in the change of the cell population to cells of 1 of 4 distinct morphologic types with, generally, an enhanced growth rate. In most altered populations, the cells were epithelioid and grew in monolayer. Treatment of the chick-embryo kidney cell cultures with BAI strain A (myeloblastosis) virus changed only about 60% of the cultures tested, with the development of 3 morphologic cell types. The predominant cell in these cultures was spindle shaped and grew in multiple layers when crowded. Little or no growth occurred in cultures not treated with virus. Cultures altered by either strain produced virions with morphology typical of avian tumor virus. The analogy between the morphology of virus-infected cells in vitro and that of the cells in tumors induced by these viruses in vivo was discussed.
PET scan’s clinical utility in detecting residual disease in postchemotherapy germ cell cancer patients
Authors: D. A. Lewis, M. Tann, A. McCool, K. Kessler, L. Einhorn
Journal: Journal of Clinical Oncology (2005)

4574 Background: The goal for metastatic germ cell tumors is cure. Cisplatin-based chemotherapy is effective in achieving this goal. Salvage therapy, including high dose chemotherapy, can cure some refractory patients. After completion of chemotherapy, residual masses may be seen on CT Scans. PET scans may help determine if these masses reflect persistent disease, which helps decide which patients need further intervention, especially as it relates to metastatic seminoma. Methods: Retrospective analysis of PET Scans in 30 germ cell cancer patients was done at Indiana University. 17 had seminoma; 13 had nonseminomatous tumors. PET Scans were done a minimum of 6 weeks post-chemotherapy. 40 PET Scans were evaluated - 14 after primary chemotherapy and 26 after salvage chemotherapy. Results: The sensitivity and specificity of PET Scans in detecting residual disease were 95% and 90%, respectively. For PET scans conducted after initial chemotherapy, sensitivity and specificity were 100% and 88%, compared to 92% and 92% after salvage chemotherapy. With seminomas, sensitivity was 100% and specificity was 87%. However, of the seven seminoma patients with positive PET scans, three had only necrosis found at surgery. Of these three patients, one relapsed in the same PET positive area and thus the active seminoma was not detected during prior surgery. The positive predictive value of our seminoma PET scans was 71% (5/7). With nonseminonatous disease, sensitivity was 92% and specificity was 100%. One nonseminomatous patient with a negative PET scan relapsed 7 months later. Conclusion: Postchemotherapy PET scans have a high sensitivity and specificity in decision analysis of residual radiographic masses. A positive PET scan supports persistent tumor requiring further therapy, however in our small series of PET-positive seminoma, false-positive results were observed. No significant financial relationships to disclose.
Reduced Capacity for DNA Repair Synthesis in Patients With or Genetically Predisposed to Colorectal Cancer&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: R W Pero, D G Miller, M Lipkin, M Markowitz, S Gupta, S J Winawer, W Enker, R Good
Journal: JNCI Journal of the National Cancer Institute (1983)

Journal Article Reduced Capacity for DNA Repair Synthesis in Patients With or Genetically Predisposed to Colorectal Cancer Get access Ronald W. Pero, Ronald W. Pero Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel G. Miller, Daniel G. Miller Search for other works by this author on: Oxford Academic PubMed Google Scholar Martin Lipkin, Martin Lipkin Search for other works by this author on: Oxford Academic PubMed Google Scholar Melvin Markowitz, Melvin Markowitz Search for other works by this author on: Oxford Academic PubMed Google Scholar Sudhir Gupta, Sudhir Gupta Search for other works by this author on: Oxford Academic PubMed Google Scholar Sidney J. Winawer, Sidney J. Winawer Search for other works by this author on: Oxford Academic PubMed Google Scholar Warren Enker, Warren Enker Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert Good Robert Good Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 70, Issue 5, May 1983, Pages 867–875, https://doi.org/10.1093/jnci/70.5.867 Published: 01 May 1983 Article history Received: 31 August 1982 Accepted: 05 January 1983 Published: 01 May 1983
Effect of history of alcoholism or major depression on smoking cessation
Authors: L S Covey, A H Glassman, F Stetner, J Becker
Journal: American Journal of Psychiatry (1993)

The authors examined the influence of a history of alcoholism or major depression on smoking cessation for 220 subjects. The success rate of recovering alcoholics was comparable to that of nonalcoholics, comorbidity of alcoholism and major depression exerted a detrimental effect, and smoking cessation did not precipitate an alcoholic relapse.
Theranostics: Carbon Dots with Intrinsic Theranostic Properties for Bioimaging, Red‐Light‐Triggered Photodynamic/Photothermal Simultaneous Therapy In Vitro and In Vivo (Adv. Healthcare Mater. 6/2016)
Authors: Jiechao Ge, Qingyan Jia, Weimin Liu, Minhuan Lan, Bingjiang Zhou, Liang Guo, Hangyue Zhou, Hongyan Zhang, Ying Wang, Ying Gu, Xiangmin Meng, Pengfei Wang
Journal: Advanced Healthcare Materials (2016)

Water-dispersible and red emissive carbon dots can simultaneously generate 1O2 and heat (symbolized by the flame around the carbon dots) under 635 nm laser irradiation. As described by Y. Gu, P. Wang, and co-workers on page 665, this unique property enables C-dots to act as red light-triggered theranostic agents for imaging-guided photodynamic-photothermal therapy in vivo.
Delusional and nondelusional unipolar depression: further evidence for distinct subtypes
Authors: D S Charney, J C Nelson
Journal: American Journal of Psychiatry (1981)

In a retrospective analysis, the course, symptoms, treatment response, and personality of 54 delusional and 66 nondelusional unipolar depressed patients were compared. The delusional patients had more guilt feelings and were more ruminative, agitated, and referential than the nondelusional patients. They had a poor response to a tricyclic antidepressant therapy but good treatment outcome with a tricyclic-antipsychotic combination or ECT. The form and content of prior episodes were remarkably similar to the index episode in both groups. The authors believe that these findings support the conception of unipolar delusional depression as a distinct subtype of depressive illness.
Abstract 19247: Biventricular and Left Ventricular Pacing Reduces Stroke Work in Ventricles With Preserved Function Due to Non-Uniform Work Distribution
Authors: Espen Boe, Kristoffer Russell, Espen W Remme, Ola Gjesdal, Otto A Smiseth, Helge Skulstad
Journal: Circulation (2010)

Purpose: Pacing therapy for heart failure (HF) patients with narrow QRS has gained increasing interest. We investigated the responses to biventricular (BV) and left ventricular lateral wall (LV) pa...
Peritumoral Lymphovascular Invasion Impacts the Incidence of Sentinel Lymph Node (Sln) Metastasis in Early Breast Cancer Patients (Pts) with Favorable Prognostic Features: a Retrospective Study on 345 Cases
Authors: N.M. La Verde, C. Casiraghi, C. Dazzani, I.C. Floriani, E. Biagioli, A. Cordovana, C. Gerardi, G. Farina, M. Lamera, S. Di Cosimo, A.M. Croce, C. Lunghi, F. Bianchi, M. Bonavita, G. Gherardi
Journal: Annals of Oncology (2014)
Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease
Authors: Kshipra Hemal, Neha J. Pagidipati, Adrian Coles, Rowena J. Dolor, Daniel B. Mark, Patricia A. Pellikka, Udo Hoffmann, Sheldon E. Litwin, Melissa A. Daubert, Svati H. Shah, Kevin Ariani, Renée P. Bullock-Palmer, Beth Martinez, Kerry L. Lee, Pamela S. Douglas
Journal: JACC. Cardiovascular imaging (2016)
Anti-KCNH2 Antibody-Induced Long QT Syndrome
Authors: Kazufumi Nakamura, Yusuke Katayama, Kengo F. Kusano, Kayo Haraoka, Yoshinori Tani, Satoshi Nagase, Hiroshi Morita, Daiji Miura, Yoshihisa Fujimoto, Tetsushi Furukawa, Kazuo Ueda, Yoshiyasu Aizawa, Akinori Kimura, Yoshihisa Kurachi, Tohru Ohe
Journal: Journal of the American College of Cardiology (2007)
P-177 Phase II trial of capecitabine + nab-paclitaxel in patients with metastatic pancreatic adenocarcinoma
Authors: W. Scheithauer, G. Kornek, G. Prager, N. Stranzl, F. Längle, M. Schindl, J. Friedl, J. Klech, S. Roethlin, C. Zielinski
Journal: Annals of Oncology (2015)
Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors
Authors: Abraham S. Kanate, Alberto Mussetti, Mohamed A. Kharfan-Dabaja, Kwang W. Ahn, Alyssa DiGilio, Amer Beitinjaneh, Saurabh Chhabra, Timothy S. Fenske, Cesar Freytes, Robert Peter Gale, Siddhartha Ganguly, Mark Hertzberg, Evgeny Klyuchnikov, Hillard M. Lazarus, Richard Olsson, Miguel-Angel Perales, Andrew Rezvani, Marcie Riches, Ayman Saad, Shimon Slavin, Sonali M. Smith, Anna Sureda, Jean Yared, Stefan Ciurea, Philippe Armand, Rachel Salit, Javier Bolaños-Meade, Mehdi Hamadani
Journal: Blood (2015)
Oncornavirus-Like Particles in Baboon Type C Virus-Infected Chimpanzee Lung Cells (SFRE:CL-1) 2
Authors: G. C. Smith, R. J. Helmke, R. L. Heberling, S. T. Barker, S. S. Kalter
Journal: JNCI Journal of the National Cancer Institute (1976)

Intracytoplasmic type A particles were observed in I a fetal chimpanzee lung culture (SFRE:CL-1) inoculated with type C virus-containing supernatants from a coculture of baboon placenta and SFRE:CL-1 cells. Budding, immature, and mature type C particles were also noted. In thin section, spike-like structures were rarely detected on budding intracytoplasmic type A particles but were occasionally observed on some immature and mature virus particles. Unlike mouse mammary tumor virus or Mason-Pfizer monkey virus, infected SFRE:CL-1 cells contained no eccentric or rodshaped nucleoids.
Analysis of the Adjuvant Hormone Therapy Randomized Trial
Authors: Yusuf Karakas, Serkan Akin, Omer Dizdar, Sercan Aksoy
Journal: Journal of Clinical Oncology (2016)

period of AHTuse was 1.14 years. Such a short period of treatment was associated with a 33% reduction in the risk of ovarian cancer recurrence (hazard ratio, 0.67; 95% CI, 0.47 to 0.97). When compared with the magnitude of benefit from tamoxifen in breast cancer(treatment of5yearswasassociatedwitha39%reduction in the risk of recurrence), 10 this finding is striking and should be validated in larger cohorts before widespread use can be suggested.
Monocyte MicroRNA Expression in Active Systemic Juvenile Idiopathic Arthritis Implicates MicroRNA‐125a‐5p in Polarized Monocyte Phenotypes
Authors: Grant S. Schulert, Ndate Fall, John B. Harley, Nan Shen, Daniel J. Lovell, Sherry Thornton, Alexei A. Grom
Journal: Arthritis & Rheumatology (2016)

Objective Systemic juvenile idiopathic arthritis (JIA) is an inflammatory disease of childhood in which cells of the monomyelocytoid lineage are thought to be key effector cells. Monocytes from patients with systemic JIA have a distinct phenotype, with features of both M1 and M2 alternative activation. MicroRNAs are critical regulators of monocyte polarization and function, but cellular microRNAs in systemic JIA have not been examined systematically. Methods MicroRNA TaqMan arrays were used to determine the expression profiles of monocytes from children with systemic JIA. Expression of microRNA‐125a‐5p (miR‐125a‐5p) and its contribution to monocyte polarization were examined using in vitro–polarized THP‐1 cells and primary human monocytes. Results A total of 110 microRNAs were found to be differentially expressed in monocytes from patients with active systemic JIA, including molecules implicated in rheumatoid arthritis pathogenesis, cytokine production, and monocyte polarization. MicroRNA‐125a‐5p was identified as being highly up‐regulated in monocytes from children with active systemic JIA, as compared to those from children with clinically inactive JIA or those with active polyarticular JIA, and correlated with systemic features of the disease. In vitro, monocyte miR125a‐5p expression was increased after polarization under M2b or M2c conditions. Inhibition of miR‐125a‐5p showed that this microRNA contributed to full polarization of M2b regulatory macrophages. In contrast, miR‐125a‐5p overexpression enhanced M2b polarization and altered other polarized populations, including increasing the production of M2 markers. Indeed, in vitro overexpression of this microRNA altered the macrophage phenotype toward that observed in systemic JIA. Conclusion Children with active systemic JIA have profound alterations in the expression of microRNAs that are implicated in monocyte function and polarization. One of these microRNAs, miR‐125a‐5p, is also a regulator of immunoregulatory M2b macrophages.
Diagnostic pattern for neuroses in China, Japan, and the United States
Authors: W S Tseng, X Di, K Ebata, J Hsu, C Yuhua
Journal: American Journal of Psychiatry (1986)

To investigate the diagnostic patterns for neuroses in China, Japan, and the United States, the authors showed videotapes and brief written case histories of six Chinese patients to psychiatrists and psychiatrists-in-training in Beijing, Tokyo, and Honolulu. In cases with a well-distinguished clinical picture the diagnoses were congruent in the three countries. Diagnostic disagreement occurred in cases with symptoms of decline in mental function, which were overwhelmingly diagnosed as neurasthenia by the Chinese clinicians, and cases with situational stress, which were diagnosed as adjustment reaction by the Americans. This illustrates that different professional concepts and classification systems are used in different countries.
Comment on Anjana et al. Incidence of Diabetes and Prediabetes and Predictors of Progression Among Asian Indians: 10-Year Follow-up of the Chennai Urban Rural Epidemiology Study (CURES). Diabetes Care 2015;38:1441–1448
Authors: Keishi Yamauchi, Toru Aizawa
Journal: Diabetes Care (2016)

Anjana et al. (1) analyzed the rate of worsening of glucose metabolism in subjects with normal glucose tolerance (NGT) and impaired fasting glucose (IFG)/impaired glucose tolerance (IGT), the rate of regression from abnormal glucose metabolism to NGT, and the risk factors for the worsening in an Asian Indian cohort. The study may be a valuable addition to the previously accumulated knowledge in the epidemiology of the diabetes evolution. However, we are afraid that the classification of glucose tolerance categories and terminology were confusing and misleading in their study. Namely, the current definition of prediabetes by the American Diabetes Association is …
Abstract 18017: Validations for the Reliability of a Dedicated 3-Dimensional Speckle Tracking Imaging System for Right Ventricular Function Analysis
Authors: Akiko Atsumi, Yoshihiro Seo, Akihiro Nakamura, Tomoko Ishizu, Yoshiharu Enomoto, Tomoya Okazaki, Yasuhiko Abe, Kazutaka Aonuma
Journal: Circulation (2014)

Background: Three-dimensional (3D) imaging has the potential to evaluate right ventricular (RV) function accurately because of its complex geometry. We have developed a dedicated 3D-speckle tracking imaging (STI) system for the right ventricle, and performed validation studies to assess the reliability of 3D-STI derived deformation data. Methods: In 9 anesthetized sheep, RV full volume data sets for 3D-STI were obtained using a 3D echocardiography system (Toshiba Medical Systems) simultaneously with sonomicrometry data at the baseline and during pulmonary artery (PA) banding at moderate and severe levels, and propranolol infusion. In 7 RV segments (basal and mid anterior, basal and mid lateral, basal and mid inferior, and outflow), area change ratio (ACR), longitudinal strain (LS), and circumferential strain (CS) were calculated with prototype 3D-STI software (Figures) and compared with those by sonomicrometry. Results: ACR by 3D-STI strongly correlated with sonomicrometry data (Y=0.78X-5.0, R=0.83, p&lt;0.001). LS and CS also showed significant correlations between the modalities (LS; Y=0.78X-1.8, R=0.79, CS; Y=0.62X-2.9, R=0.77, p&lt;0.001). In segmental analysis, all deformation data showed significant correlations in each segment. During PA banding, PA pressure increased at a moderate (48.4±8.4mmHg) and a severe level (53.9±8.5mmHg mmHg) compared to the baseline (22.5±4.6mmHg). In contrast, 3D-STI data had graded decreases at the baseline, moderate and severe levels (ACR; -32.5±8.3, -24.2±10.0, -16.1±10.9%, p&lt;0.001, LS; -16.0±6.2, -9.5±6.8, -5.1±7.7%, p&lt;0.001, CS; -16.3±5.4, -12.6±7.6, -9.3±7.3%, p=0.003). During propranolol infusion, RV dP/dt was significantly decreased compared to the baseline (807±287 vs. 535±199 mmHg/s, p=0.01), and 3D-STI data also reduced (ACR; -23.3±7.7, LS; -10.4±5.8, CS; -11.5±5.4, p&lt;0.05 vs. baseline). Conclusions: The newly developed 3D-STI system is a reliable modality for RV function analysis.
SAT0428 Application of New Eular Definitions of Remission in SLE: Durable One-Year Remission is Rare: Table 1.
Authors: T.R. Fischer, M. Petri, L.S. Magder
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Developing definition(s) of remission in SLE is one of the primary recommendations on the research agenda of the treat-to-taget (T2T/SLE) international task force [1] as it is required to apply the important principle of T2T to SLE. Definitions of remission were agreed on by an international collaboration from the EULAR working group. <h3>Objectives</h3> We applied the definitions from the EULAR working group to a large clinical cohort to determine the distribution of time to remission, durability and predictors of remission. <h3>Methods</h3> Remission was defined as clinical Systemic Lupus Disease Activity Index (SLEDAI) =0, with Physician Global Assessment (PGA) ≤0.5, prednisone ≤5 mg per day and no immunosuppression. Remission on treatment (ROT) was defined as clinical SLEDAI =0, with PGA ≤0.5, prednisone ≤5 mg per day and allowance of immunosuppressives. Hydroxychloroquine was allowed for remission and ROT. The Kaplan-Meier approach was used to estimate the distribution of time until remission among patients who entered the cohort with disease activity. In addition, for patients on treatment, we identified variables that were predictive of remission in the next two visits. <h3>Results</h3> The median time to remission was 2.8 years in women and 5.7 years in men, whereas the median time to ROT was 1.3 years in women and 2.1 years in men. Of those who satisfied the definition of remission, 59% had a relapse manifested at a clinic visit within the next 90 days, and 15% more had a relapse from 90 to 180 days post remission. Only 11% had a remission lasting over one year. Considering patients treated with immunosuppressives or prednisone greater than 5 mg/day at one visit, 2.8% successfully tapered treatment and achieved remission over the next two visits. The table below shows rates of remission in various subgroups. <h3>Conclusions</h3> 50% of women and men with SLE achieve remission within 2.8 years and 5.7 years, respectively. However, most of them experience a relapse within the next 90 days. This reflects the relapsing-remitting nature of SLE for many patients. Remission and remisson on treatment are frequent in SLE. Durable remission, though, is rare. Only 11% will have durability of more than one year. African-American ethnicity, anti-dsDNA or low complement predict against achieving remission. Our results provide further insights into the nature of remission in SLE and contribute towards applying the treat-to-target principle to SLE. <h3>References</h3> van Vollenhoven, R.F., et al., Treat-to-target in systemic lupus erythematosus: recommendations from an international task force. Ann Rheum Dis, 2014. 73(6): p. 958-67. <h3>Disclosure of Interest</h3> None declared