Crohn Disease: A Hopeful Note
Authors: HARVEY J. DWORKEN
Journal: Annals of Internal Medicine (1981)

Editorials1 December 1981Crohn Disease: A Hopeful NoteHARVEY J. DWORKEN, M.D.HARVEY J. DWORKEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-6-777 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhysicians who treat patients with Crohn disease should take heart. Recent studies suggesting indications for and efficacy of various therapies for the disease are remarkable, considering that knowledge of its cause has not as yet moved very far beyond the killer lymphocyte stage (1) and shows no signs of early progress therefrom.Therapy in Crohn disease should be tailored to the stage of the disorder. Although detailed staging techniques have been developed (2, 3), they are almost too clumsy for use in daily practice where a simpler classification is preferable. Thus, patients can usually be assigned to one of three...References1. BRITTONEKLUNDBIRD SAA. Appearance of killer (K) cells in the mesenteric lymph nodes in Crohn's disease. Gastroenterology. 1978;75:218-20. CrossrefMedlineGoogle Scholar2. BESTBECKTELSINGLETON WJJ. Rederived values of the eight coefficients of the Crohn's disease activity index (CDAI). Gastroenterology. 1979;77:843-6. CrossrefMedlineGoogle Scholar3. VAN HEESVAN ELTERENVAN LIERVAN TONGEREN PPHJ. An index of inflammatory activity in patients with Crohn's disease. Gut. 1980;21:279-86. CrossrefMedlineGoogle Scholar4. SCHÖDERCAMPBELL HD. Absorption, metabolism and excretion of salicylazosulfapyridine in man. Clin Pharm Ther. 1972;13:539-51. CrossrefMedlineGoogle Scholar5. KLOTZMAIERFISCHERHEINKEL UKCK. Therapeutic efficacy of sulfasalazine and its metabolites in patients with ulcerative colitis and Crohn's disease. N Engl J Med. 1980;303:1499-502. CrossrefMedlineGoogle Scholar6. SUMMERSSWITZSESSIONS RDJ. National Cooperative Crohn's Disease Study: results of drug treatment. Gastroenterology. 1979;77:847-69. CrossrefMedlineGoogle Scholar7. VAN HEESVAN LIERVAN ELTEREN PHP. Effect of sulphasalazine in patients with active Crohn's disease: a controlled double-blind study. Gut. 1981;22:404-9. CrossrefMedlineGoogle Scholar8. SINGLETONLAWKELLEYMEKHJIANSTURDEVANT JDMHR. National Cooperative Crohn's Disease Study: adverse reactions to study drugs. Gastroenterology. 1979;77:870-82. CrossrefMedlineGoogle Scholar9. PRESENTKORELITZWISCHGLASSSACHARPASTERNACK DBNJDB. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med. 1980;307:981-7. CrossrefGoogle Scholar10. LOGANGILLONFERRINGTONFERGUSON RJCA. Reduction of gastrointestinal protein loss by elemental diet in Crohn's disease of the small bowel. Gut. 1981;22:383-7. CrossrefMedlineGoogle Scholar11. GOODEHAWKINSFEGETTERJOHNSTON ATII. Use of an elemental diet for long-term nutritional support in Crohn's disease. Lancet. 1976;1:122-4. CrossrefMedlineGoogle Scholar12. LAYDENROSENBERGNEMCHAUSKYELSONROSENBERG TJBCI. Reverse of growth arrest in adolescents with Crohn's disease after parenteral alimentation. Gastroenterology. 1976;70:1017-21. CrossrefMedlineGoogle Scholar13. RAULTSCRIBNER RB. Treatment of Crohn's disease with home parenteral nutrition. Gastroenterology. 1977;72:1249-52. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine School of Medicine Case Western Reserve University Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCrohn DiseaseHARVEY J. DWORKEN, M.D. 1 December 1981Volume 95, Issue 6Page: 777-778KeywordsCardiovascular therapyCrohn's diseaseLymphocytes Issue Published: 1 December 1981 PDF downloadLoading ...