TREATMENT OF TYPHOID FEVER. I. COMBINED THERAPY WITH CORTISONE AND CHLORAMPHENICOL
Authors: J E SMADEL, H L LEY, F H DIERCKS
Journal: Annals of Internal Medicine (1951)

Article1 January 1951TREATMENT OF TYPHOID FEVER. I. COMBINED THERAPY WITH CORTISONE AND CHLORAMPHENICOLJOSEPH E. SMADEL, HERBERT L. LEY JR., FRED H. DIERCKSJOSEPH E. SMADELSearch for more papers by this author, HERBERT L. LEY JR.Search for more papers by this author, FRED H. DIERCKSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChloramphenicol now has an established place in the treatment of typhoid fever.1, 2, 3, 4, 5However, it has been our observation, as well as that of others, that little if any clinical improvement occurs during the first 36 hours of therapy and that the patients do not become afebrile until about the fourth day. This delay in therapeutic response is difficult to explain, since previous experience shows that the bacterial organisms are promptly controlled by specific therapy.3Indeed, the bacteremia ceases several days before fever and toxemia subside. However, it has seemed reasonable to postulate that the delayed clinical...Bibliography1. WoodwardSmadelLeyGreenMankikar TEJEHLRDS: Preliminary report on the beneficial effect of chloromycetin in the treatment of typhoid fever, Ann. Int. Med. 29: 131-134, 1948. LinkGoogle Scholar2. Smadel JE: Chloramphenicol (chloromycetin) in the treatment of infectious diseases, Am. J. Med. 7: 671-685, 1949. CrossrefMedlineGoogle Scholar3. WoodwardSmadelLey TEJEHL: Chloramphenicol and other antibiotics in the treatment of typhoid fever and typhoid carriers, J. Clin. Investigation 29: 87-99, 1950. CrossrefMedlineGoogle Scholar4. Anonymous: Chloromycetin in typhoid fever, Lancet 1: 720-722, 1950. Google Scholar5. 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Paratyphus. Biologische Wirkungen und NebenerscheinungenTHE CLINICAL APPLICATION OF PITUITARY ADRENOCORTICOTROPIC AND ADRENAL STEROID HORMONES*LAURANCE W. KINSELL, M.D., F.A.C.P.ACTH and Cortisone in InfectionThe Role of Adrenal Steroids in Infection and ImmunityTREATMENT OF TYPHOID FEVER. II. CONTROL OF CLINICAL MANIFESTATIONS WITH CORTISONE*T. E. WOODWARD, M.D., H. E. HALL, M.D., R. DIAS-RIVERA, M.D., J. A. HIGHTOWER, M.D., E. MARTINEZ, M.D., R. T. PARKER, M.D. 1 January 1951Volume 34, Issue 1Page: 1-9KeywordsArmed forcesBacteremiaChloramphenicolFeversGraduate medical educationHyperthermiaTyphoid ePublished: 1 December 2008 Issue Published: 1 January 1951 Copyright & PermissionsCopyright, 1951, by The American College of PhysiciansPDF downloadLoading ...