tbuckley/cabot-search huggingface dataset:
S0216: A Southwest Oncology Group (SWOG) phase II trial of docetaxel (T), cisplatin (P), and fluorouracil (F) induction followed by accelerated fractionation/concomitant boost (AF/CB) radiotherapy (RT) and concurrent cisplatin for advanced head and neck squamous cell cancer (HNSCC)
Authors: D. J. Adelstein, J. Moon, E. Hanna, P. G. Shankar Giri, G. M. Mills, G. T. Wolf, S. G. Urba
Journal: Journal of Clinical Oncology (2007)

6014 Background: Randomized trials have suggested benefit from three-drug taxane-containing induction chemotherapy, and from AF/CB RT in patients (pts) with locoregionally advanced HNSCC. In an effort to optimize non-operative therapy, this SWOG phase II trial combined these two interventions with standard concurrent single-agent cisplatin. Methods: Eligibility required a diagnosis of untreated stage III or IV (M0) HNSCC deemed appropriate for RT with curative intent, a performance status of 0–1, and adequate hematologic, renal, and hepatic function. Two courses of induction TPF (T 75 mg/m 2 day (d)1, P 100 mg/m 2 d1, and F 1,000 mg/m 2 /d as a 24 hour continuous IV infusion d1–4) were given, 21 days apart. Stable or responding pts received definitive AF/CB RT; 54 Gy in 30 fractions (fx) to the total volume, with a concomitant boost of 18 Gy in 12 fx given on the last 12 treatment days. Concurrent cisplatin (100 mg/m 2 ) was given on d1 and d22 of the RT. An accrual of 60 pts was planned using a one-stage study design. The primary endpoint was overall survival (OS). Secondary endpoints were toxicity and response. Results: Between 3/1/03 and 8/15/04, 76 pts were enrolled; 74 were eligible and evaluable. The median age was 54 years; 82% were male, and 77% white. 52 pts (70%) had stage IV disease. 40 pts (54%) experienced at least one grade (G)4 toxicity during induction, including neutropenia in 32, with fever in 13. 62 pts completed induction and began concurrent chemoradiotherapy (CCRT); 50 completed all planned treatment. 57 pts have been evaluated for toxicity from CCRT. At least one G4 toxicity was noted in 20 pts, including neutropenia in 6, with fever in 3. There were 2 treatment-related deaths during induction, and 2 during CCRT. With a median follow-up of 27 months, the 2-year projected OS is 72% (95% CI 62%-83%), with a projected progression-free survival (PFS) of 66% (95% CI 55%-77%). Conclusions: TPF induction followed by AF/CB RT and concurrent cisplatin is toxic but feasible within a cooperative group. In this cohort of pts with advanced HNSCC, OS and PFS are encouraging, and justify further study of this approach. No significant financial relationships to disclose.
SAT0373 Role of Inkt Cells in Patients with Primary Sjogren Syndrome
Authors: G. Guggino, F. Ciccia, S. Raimondo, R. Alessandro, F. Dieli, G. Triolo, G. Sireci
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> iNKT cells represent a T cell subset at the bridge between innate and adaptive immunity, playing a role in regulating auto-antibody-producing B cells before their entry into germinal centers. Therefore the absence and/or reduction of iNKT cells seem to increase auto-reactive B cell activation. Primary Sjogren9s syndrome (pSS) is a systemic autoimmune disease in which lymphocyte infiltration and organization in lymphoid structures of inflamed salivary glands occur. <h3>Objectives</h3> The aim of this study was to investigate the frequency of iNKT in the salivary glands and peripheral blood of patients with pSS and their function by using CD1d/aGalactosylceramide (aGalaCer) tetramers. <h3>Methods</h3> Flow cytometry analysis of <i>ex vivo</i> frequency of tetramer<sup>+</sup> cells, producing IFN-g and IL-17, and quantitative gene expression analysis by real-time PCR for Va24 chain expression was performed on salivary glands and peripheral blood obtained from patients and controls. Flow cytometric analysis and immune fluorescence for autoreactive B lymphocytes and ELISA for anti-SSA detection were also performed. <h3>Results</h3> A significant expansion of IL-17<sup>+</sup>- and IFN-γ<sup>+</sup>-producing iNKT cells, expressing low levels of the chemokine receptors CXCR3, CCR6 and CCR5, was observed in the peripheral blood of pSS patients. In the inflamed salivary glands, iNKT were absent whereas a significant increase of SSA specific B cells occurs. Moreover, co-culture experiments i<i>n vitro</i> demonstrate that activated iNKT inhibit autoantibody production by autoreactive B cells from pSS patients. <h3>Conclusions</h3> An impaired tissue migration of iNKT may lead to the expansion of autoreactive B cells specific for SSA -antigen in salivary glands of patients, suggesting an important role of iNKT in regulating B cells activation in pSS. <h3>References</h3> Bendelac, A., P. B. Savage, and L. Teyton. The biology of NKT cells. Annu Rev Immunol 2007;25: 297-336. Yang JQ, Wen X, Kim PJ, Singh RR. Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependentmanner. Invariant NKT cells inhibit autoreactive B cells in a contact- and CD1d-dependent manner. J Immunol. 2011 Feb 1;186(3):1512-20. Wu L, Gabriel CL, Parekh VV, Van Kaer L. Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities. Tissue Antigens 2009 Jun;73(6):535-45. <h3>Disclosure of Interest</h3> None declared
Refugees' time perspective and mental health
Authors: M Beiser, I Hyman
Journal: American Journal of Psychiatry (1997)

The authors' goal was to investigate factors protective of the mental health of refugees, with a particular focus on time splitting and suppression of the past.Structured interviews covering premigration and postmigration stresses, personal and social resources, and mental health were given to 1,348 Southeast Asian refugees resettled in Vancouver, British Columbia, and to a comparison sample of 319 residents of Vancouver. Both groups of subjects also performed a task designed to measure orientation toward past, present, and future.Compared with resident Canadians, refugees were more likely to exhibit an atomistic time perspective in which past, present, and future are split. Temporal atomism and avoidance of nostalgia were associated with a lower risk of depression than were other time perspectives.Under conditions of extreme adversity, time splitting and suppression of the past may be adaptive strategies, mitigating the risk of depression.
Glycolipids in Histologically Human Different Lung Carcinoma Types<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>
Authors: Y Yoda, S Gasa, A Makita, Y Fujioka, Y Kikuchi, M Hashimoto
Journal: JNCI Journal of the National Cancer Institute (1979)

Glycolipids were isolated from primary human lung carcinoma tissue of various histologic types: adenocarcinoma, squamous cell carcinoma, and undifferentiated small cell carcinoma. Each type of carcinoma had a characteristic glycolipid pattern. The major glycolipids isolated were ceramide monohexosides, ceramide dihexosides, ceramide trihexosides, globoside, and hematoside. Squamous cell carcinoma and undifferentiated small cell carcinoma showed marked increases of ceramide monohexosides and dihexosides. Adenocarcinoma had a much higher level of the sulfatide (ceramide 3-sulfate-galactoside) as compared to squamous cell carcinoma, undifferentiated small cell carcinoma, or normal lung tissue. Embryonic tissue had more significant levels of sulfatide than did the other carcinomas. Adenocarcinoma had significantly lower levels of glycolipids due mainly to a decrease in the amount of ceramide monohexosides and dihexosides and hematoside.
The Behavior Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease
Authors: P N Tariot, J L Mack, M B Patterson, S D Edland, M F Weiner, G Fillenbaum, L Blazina, L Teri, E Rubin, J A Mortimer
Journal: American Journal of Psychiatry (1995)

The purpose of the study was to develop a standardized instrument, the Behavior Rating Scale for Dementia, for rating psychopathology in patients with probable Alzheimer's disease and to conduct a multicenter pilot study of this instrument.The rating scale was developed collaboratively on the basis of clinical experience and existing instruments. Items were scaled according to frequency of psychopathology and were administered to an informant who was familiar with the subject. The scale was administered in a standardized manner by trained examiners who had met predetermined certification standards. The study group consisted of 303 subjects with probable Alzheimer's disease who had undergone standardized clinical evaluations by the Consortium to Establish a Registry for Alzheimer's Disease.Subjects had an average of 15 problems rated as present in the preceding month. Wide variability in the nature of disturbances was found, with a number of items rated as present since the illness began but not in the past month. Interrater agreement was high. Factor analysis suggested eight preliminary factors that mapped onto clinically relevant domains: depressive features, psychotic features, defective self-regulation, irritability/agitation, vegetative features, apathy, aggression, and affective lability.The Behavior Rating Scale for Dementia provides a standardized, reliable measure that can be administered to caregivers of demented subjects. On the basis of the present study, the scale has been revised slightly. After additional studies in progress, the Behavior Rating Scale for Dementia will be available for general use in assessing a wide range of psychopathology in dementia.
Relation of Adrenal Cortical Function to Scurvy in Guinea-pigs
Authors: B. E. Clayton, F. T. G. Prunty
Journal: BMJ (1951)

The reported claims of recent isolations of classical influenza virus A strains are considered.The evidence suggests that these claims should be viewed with great caution.We should like to thank Dr. A. W. Gledhill for his help in preparing immune ferret sera and Mr. E. Owen for his most
Neuroendocrine and neurochemical measurements in depression
Authors: K L Davis, L E Hollister, A A Mathé, B M Davis, A B Rothpearl, K F Faull, J Y Hsieh, J D Barchas, P A Berger
Journal: American Journal of Psychiatry (1981)

The authors performed dexamethasone suppression tests (DST), TRH infusions, 72-hour urine collections, and lumbar punctures on a group of male depressed patients. Approximately 60% of the patients were DST positive and 33% had a blunted TSH response. Two biologic variables, the 8 a.m. postdexamethasone cortisol and the postprobenecid CSF 5-hydroxyindoleacetic acid (5-HIAA), accounted for over half of the variance in the behavioral measure, the Hamilton score. Plasma cortisol elevation was associated with high 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion; TSH blunting was associated with low urinary MHPG excretion. Comprehensive biologic measures showed certain significant interrelationships and correlations with the severity of depression.
A Targetable Molecular Chaperone Hsp27 Confers Aggressiveness in Hepatocellular Carcinoma
Authors: Yurong Zhang, Xuemei Tao, Guangzhi Jin, Haojie Jin, Ning Wang, Fangyuan Hu, Qin Luo, Huiqun Shu, Fangyu Zhao, Ming Yao, Jingyuan Fang, Wenming Cong, Wenxin Qin, Cun Wang
Journal: Theranostics (2016)

Heat shock protein 27 (Hsp27) is an ATP-independent molecular chaperone and confers survival advantages and resistance to cancer cells under stress conditions. The effects and molecular mechanisms of Hsp27 in HCC invasion and metastasis are still unclear. In this study, hepatocellular carcinoma (HCC) tissue array (n = 167) was used to investigate the expression and prognostic relevance of Hsp27 in HCC patients. HCC patients with high expression of Hsp27 exhibited poor prognosis. Overexpression of Hsp27 led to the forced invasion of HCC cells, whereas silencing Hsp27 attenuated invasion and metastasis of HCC cells in vitro and in vivo. We revealed that Hsp27 activated Akt signaling, which in turn promoted MMP2 and ITGA7 expression and HCC metastasis. We further observed that targeting Hsp27 using OGX-427 obviously suppressed HCC metastasis in two metastatic models. These findings indicate that Hsp27 is a useful predictive factor for prognosis of HCC and it facilitates HCC metastasis through Akt signaling. Targeting Hsp27 with OGX-427 may represent an attractive therapeutic option for suppressing HCC metastasis.
PARE0004 « Together against the first bone fracture » : an andar-aflar information leaflet to prevent osteoporosis-induced complications in ra patients
Authors: L. Grange, T. Thomas, F. Levy-Weil, R.-M. Javier, D. Gasqueres, J.-N. Dachicourt, S. Chirol
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Beyond 50, at least one out of three women and one out of eight men will develop an osteoporosis-induced bone fracture[1]. Rheumatoid arthritis (RA) is an auto-immune disease which affects around 300,000 persons in France. This painful and disabling condition is the most common chronic inflammatory joint disease. RA increases the risk of bone weakness and, therefore, of bone fracture. This increased susceptibility is due to the chronic inflammatory activity which characterizes RA. Others factors may also contribute such as&nbsp;: menopause, corticotherapy and decrease in physical activity. AFLAR, created in 1928 to promote the fight against osteoarthritis (osteoarthrosis), is the only French non-profit organization helping patients with osteoporosis. Since 1984, ANDAR has been helping RA patients to raise awareness about their disease and has been supporting them throughout their daily difficulties. <h3>Objectives</h3> To inform RA patients about the prevention of osteoporosis-induced complications (especially bone fractures), these two non-profit organisations joined their efforts in 2012 to publish a leaflet entitled «&nbsp;Together against the first bone fracture&nbsp;». <h3>Methods</h3> An editorial committee was created with representatives of AFLAR and ANDAR, proof-reading patients, two rheumatologists and a physical therapist specializing in osteoporosis and RA. This committee agreed on prevention and awareness messages about osteoporosis to be communicated to RA patients, and on the leaflet summary. Later, committee members validated the content and lay-out of the leaflet. <h3>Results</h3> AFLAR and ANDAR produced a leaflet on a theme which has rarely been put forward with RA patients. This document explores&nbsp;: the links between RA and osteoporosis-induced fractures (chronic inflammatory activity, corticotherapy, lack of physical activity, menopause), the general risk factors of osteoporosis, the evaluation of bone quality (bone densitometry) and osteoporosis prevention measures (balanced diet, regular physical activity, vitamin D supplementation). <h3>Conclusions</h3> This leaflet is an information and prevention tool which stresses a concern rarely mentioned to RA patients. Its richness stems from the joint efforts of patients, patient organizations and healthcare professionals involved in the medical care of osteoporosis and RA. <h3>References</h3> Dargent-Molina P. Epidémiologie et facteurs de risque de l’ostéoporose. La Revue de Médecine Interne 25(2004) S517-S525 <h3>Acknowledgements</h3> This leaflet was published with Chugai Pharma France financial support. <h3>Disclosure of Interest</h3> None Declared
In Vivo Marking of Rhesus Monkey Lymphocytes by Adeno-Associated Viral Vectors: Direct Comparison With Retroviral Vectors
Authors: Yutaka Hanazono, Kevin E. Brown, Atsushi Handa, Mark E. Metzger, Dominik Heim, Gary J. Kurtzman, Robert E. Donahue, Cynthia E. Dunbar
Journal: Blood (1999)
Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior
Authors: Catherine Monk, Tianshu Feng, Seonjoo Lee, Izabela Krupska, Frances A. Champagne, Benjamin Tycko
Journal: American Journal of Psychiatry (2016)

Objective: Increased risk of psychopathology is observed in children exposed to maternal prenatal distress, and elevated maternal cortisol and epigenetic regulation of placental glucocorticoid-pathway genes are potential mechanisms. The authors examined maternal distress and salivary cortisol in relation to fetal movement and heart rate (“coupling”) and DNA methylation of three glucocorticoid pathway genes—HSD11B2, NR3C1, and FKBP5—in term placentas. Method: Mood questionnaires and salivary cortisol were collected from 61 women between 24–27 gestational weeks, and fetal assessment was conducted at 34–37 weeks. Placental CpG methylation in the three genes was analyzed using 450K Beadchips and bisulfite sequencing; correlations between maternal and fetal variables and DNA methylation were tested; and maternal distress effects on fetal behavior via DNA methylation were investigated. Results: Perceived stress (Perceived Stress Scale), but not cortisol, was associated with altered CpG methylation in placentas. In the highest tertile of the Perceived Stress Scale, the Beadchip data revealed modestly elevated methylation of HSD11B2, associated with lower fetal coupling (β=−0.51), and modestly elevated methylation of FKBP5, also with lower fetal coupling (β=−0.47). These increases in methylation were validated by bisulfite sequencing, where they occurred in a minority of clones. Conclusions: This is the first study to link the effects of pregnant women's distress on the fetus and epigenetic changes in placental genes. Since increased DNA methylation in HSD11B2 and FKBP5 are seen in a minority of bisulfite sequencing clones, these epigenetic changes, and functional consequences, may affect subpopulations of placental cells.
Cytogenetic Studies of a Simian Virus 40 Temperature-Sensitive Mutant-Transformed Chinese Hamster Cell Clone at the Permissive and Nonpermissive Temperature&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: J M Lehman, C C Robinson
Journal: JNCI Journal of the National Cancer Institute (1978)

A clone of Chinese hamster embryo cells transformed by tsA58, the temperature-sensitive mutant of simian virus 40, was analyzed for chromosome abnormalities at the permissive temperature (37 degrees C) and nonpermissive temperature (40.5 degrees C). Trypsin-Giemsa-banded metaphases were analyzed 1 week after the temperature shift. The metaphases from cells at both temperatures were pseudodiploid, with numerous chromosome changes primarily affecting chromosomes no. 1 and 2. Other chromosomes (no. 6, 11, and the X) were also frequently involved. A marker chromosome, LM, was present in 35% of the cells at 40.5 degrees C.
Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract
Authors: Ekaterina Yonova-Doing, Zoe A. Forkin, Pirro G. Hysi, Katie M. Williams, Tim D. Spector, Clare E. Gilbert, Christopher J. Hammond
Journal: Ophthalmology (2016)

PurposeTo determine the heritability of nuclear cataract progression and to explore prospectively the effect of dietary micronutrients on the progression of nuclear cataract.DesignProspective cohort study.ParticipantsCross-sectional nuclear cataract and dietary measurements were available for 2054 white female twins from the TwinsUK cohort. Follow-up cataract measurements were available for 324 of the twins (151 monozygotic and 173 dizygotic twins).MethodsNuclear cataract was measured using a quantitative measure of nuclear density obtained from digital Scheimpflug images. Dietary data were available from EPIC food frequency questionnaires. Heritability was modeled using maximum likelihood structural equation twin modeling. Association between nuclear cataract change and micronutrients was investigated using linear and multinomial regression analysis. The mean interval between baseline and follow-up examination was 9.4 years.Main Outcome MeasuresNuclear cataract progression.ResultsThe best-fitting model estimated that the heritability of nuclear cataract progression was 35% (95% confidence interval [CI], 13–54), and individual environmental factors explained the remaining 65% (95% CI, 46–87) of variance. Dietary vitamin C was protective against both nuclear cataract at baseline and nuclear cataract progression (β = −0.0002, P = 0.01 and β = −0.001, P = 0.03, respectively), whereas manganese and intake of micronutrient supplements were protective against nuclear cataract at baseline only (β = −0.009, P = 0.03 and β = −0.03, P = 0.01, respectively).ConclusionsGenetic factors explained 35% of the variation in progression of nuclear cataract over a 10-year period. Environmental factors accounted for the remaining variance, and in particular, dietary vitamin C protected against cataract progression assessed approximately 10 years after baseline.
The Beat Goes On
Authors: John J. Ross, Kathryn A. Britton, Akshay S. Desai, William G. Stevenson
Journal: New England Journal of Medicine (2010)

A 45-year-old white man was brought to the emergency room by emergency-medical-services personnel after a syncopal event. He did not report any chest pain. He was found to have a monomorphic, wide-complex tachycardia at a rate of 240 beats per minute, with a blood pressure of 110/50 mm Hg. Amiodarone was administered without effect. His systolic blood pressure subsequently fell . . .
High dose chemotherapy followed by autologous hematopoietic rescue in Hodgkin's disease: Long term follow-up in 128 patients
Authors: P.J. Bierman, R.G. Bagin, S. Jagannath, J.M. Vose, G. Spitzer, A. Kessinger, K.A. Dicke, J.O. Armitage
Journal: Annals of Oncology (1993)
Detection of Heteroploid Tumor Cells2
Authors: P. K. Horan, A. Romero, J. A. Steinkamp, D. F. Petersen
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Detection of Heteroploid Tumor Cells Get access P. K. Horan, P. K. Horan Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Romero, A. Romero Search for other works by this author on: Oxford Academic PubMed Google Scholar J. A. Steinkamp, J. A. Steinkamp Search for other works by this author on: Oxford Academic PubMed Google Scholar D. F. Petersen D. F. Petersen 5Los Alamos Scientific Laboratory, University of California, Los Alamos, N. Mex. 87544. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 3, March 1974, Pages 843–848, https://doi.org/10.1093/jnci/52.3.843 Published: 01 March 1974 Article history Received: 14 August 1973 Accepted: 28 November 1973 Published: 01 March 1974