Penicillin-resistant Bacteria in the Mouths and Throats of Children Receiving Continuous Prophylaxis against Rheumatic Fever
Authors: RICHARD A. NAIMAN
Journal: Annals of Internal Medicine (1963)

Article1 May 1963Penicillin-resistant Bacteria in the Mouths and Throats of Children Receiving Continuous Prophylaxis against Rheumatic FeverRICHARD A. NAIMAN, M.D., J. GORDON BARROW, M.D., F.A.C.P.RICHARD A. NAIMAN, M.D.Search for more papers by this author, J. GORDON BARROW, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-768 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUntil recently, bacterial resistance to drugs used prophylactically against the recurrence of rheumatic fever has not been considered a problem. A theoretical disadvantage of any prophylaxis program is the possibility of replacement of the normal bacterial flora by drug-resistant strains. Fortunately, Group A beta-hemolytic streptococci have not been found to develop penicillin resistance; therefore, recurrence of rheumatic fever as a consequence of infection with penicillin-resistant strains in patients receiving penicillin prophylaxis has not been a problem. Little attention had been given the alpha-streptococcus (Str. viridans) as an organism capable of becoming penicillin resistant until Garrod and Waterworth (1) reported 2...References1. GARRODWATERWORTH LPPM: The risks of dental extraction during penicillin treatment. Brit. Heart J. 24: 39, 1962. CrossrefMedlineGoogle Scholar2. FEINSTEINWOODEPSTEINSIMPSONTARANTATURSKY ARHFJARSAE: Controlled study of three methods of prophylaxis against streptococcal infection in a population of rheumatic children. II. Results of the first 3 years of the study, including methods for evaluating the maintenance of oral prophylaxis. New Engl. J. Med. 260: 697, 1959. CrossrefMedlineGoogle Scholar3. WOODSTOLLERMANFEINSTEINHIRSCHFELDRUSOFFTARANTAHAASEPSTEIN HFGHARIJHARCJA: Controlled study of three methods of prophylaxis against streptococcal infection in a population of rheumatic children. I. Streptococcal infections and recurrences of acute rheumatic fever in the first two years of the study. New Engl. J. Med. 257: 394, 1957. CrossrefMedlineGoogle Scholar4. MARKOWITZHEMPHILL MW: Comparison of oral benzathine penicillin G and sulfonamides for the prevention of streptococcal infections and recurrences of rheumatic fever. Pediatrics 15: 509, 1955. MedlineGoogle Scholar5. BOWEN MK: The optochin sensitivity test: a reliable method for identification of pneumococci. J. Lab. Clin. Med. 49: 641, 1957. MedlineGoogle Scholar6. HARRISFRIEDMANHALLIDIE-SMITHCORIELLFABRIZIO TNSKALLD: Occurrence of penicillin resistant staphylococci in patients receiving penicillin orally for prophylaxis of recurrences of rheumatic fever. Amer. J. Med. 32: 545, 1962. CrossrefGoogle Scholar7. KRUMWIEDE E: Penicillin resistance of nonhemolytic streptococci from rheumatic children receiving prophylactic penicillin. Pediatrics 4: 634, 1949. MedlineGoogle Scholar8. VOGLERDORNEY WRER: Bacterial endocarditis. Amer. J. Med. 32: 910, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD A. NAIMAN, M.D.; J. GORDON BARROW, M.D., F.A.C.P.Affiliations: Atlanta, GeorgiaFrom the Cardiovascular Disease Control Service, Georgia Department of Public Health, Atlanta, Georgia.Requests for reprints should be addressed to Richard A. Naiman, M.D., Cardiovascular Disease Control Service, Department of Public Health, State of Georgia, 47 Trinity Avenue, Atlanta 3, Georgia. 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SPENCER III, M.D., CLYDE THORNSBERRY, Ph.D., MAX D. MOODY, Ph.D., NANETTE K. WENGER, M.D.Current trends in the prevention of bacterial endocarditis in susceptible patients receiving dental careA study of the oral flora in children receiving sulfadiazine prophylaxis against rheumatic feverANTIBIOTICS FOR PREVENTION OF BACTERIAL ENDOCARDITIS DURING DENTAL TREATMENTPrevention of subacute bacterial endocarditis associated with dental proceduresBacterial Endocarditis — A Changing Pattern 1 May 1963Volume 58, Issue 5Page: 768-772KeywordsDrugsEndocarditisOral healthPenicillinPharynxPrevention, policy, and public healthProphylaxisResearch laboratoriesRheumatic feverStreptococcal infections ePublished: 1 December 2008 Issue Published: 1 May 1963 PDF downloadLoading ...