tbuckley/cabot-search huggingface dataset:
Major bleeding after endoscopic biopsy in relation to use of antithrombotics
Authors: Kentaro Yamashita, Yoshiaki Arimura, Koichiro Fukuda, Kei Onodera, Kayo Murakami, Hiroyuki Isshiki, Mayuko Saito, Yasuhisa Shinomura
Journal: Endoscopy (2014)

We read with great interest the two articles about gastrointestinal bleeding after cold biopsy [1] [2]. Although endoscopic cold biopsy is regarded as a procedure with low bleeding risk, the actual incidence of delayed bleeding after cold biopsy varies among studies [1] [2] [3] [4] [5] [6]. Furthermore, the influence of antithrombotic agents (i. e., antiplatelets and anticoagulants) on post-biopsy bleeding remains unknown. We would like to describe our own experience.
Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma
Authors: Jesper Lagergren, Reinhold Bergström, Anders Lindgren, Olof Nyrén
Journal: New England Journal of Medicine (1999)

The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors.
ED-27 * CLINICAL CHARACTERISTICS AND LONG-TERM OUTCOME IN MOVEMENT DISORDER IN CHILDHOOD THALAMIC TUMORS
Authors: Z. Sadighi, J. Zabrowski, A. Broniscer, A. Gajjar, R. Khan
Journal: Neuro-Oncology (2014)

BACKGROUND: Clinical observations of children with thalamic tumors and secondary movement disorders (MD) suggest correlation between anatomical location and treatment modalities to severity of MD. METHODS: We conducted an IRB approved retrospective review of patients ≤ 18 years old with thalamic tumors and MD at St. Jude Children's Research Hospital from 1996-2013. Magnetic Resonance Imaging (MRI) was reviewed and thalamic nuclei involved with tumor and/or surgical site were documented. MD severity was rated with Karnofsky Performance Score (KPS); Extrapyramidal Symptom Rating Scale (ESRS), which scores 0 (absent) to 6 (extremely severe); and Clinical Global Impression of Severity for dystonia and dyskinesia (CGI-S), which scores 0 (absent) to 8 (extremely severe). RESULTS: We reviewed 83 patients with thalamic with 9 confirmed MD by neurological evaluation. Median age at tumor diagnosis was 7 years old (3 months-11 years), median age at MD onset was 7 years old (18 months-11 years). Types of MD found were postural tremor (7), ballismus (4), myoclonus (1), and athetosis (4). Median time to last follow-up was 3 years. 8 patients had onset of MD median of 1.5 months (0-4 months) time after surgical intervention. Initial median KPS was 80 (60-90) and at last follow-up was 80 (50-90). Initial median ESRS was 5 (3-8) and at last follow-up was 5 (0-5). Initial median CGI-S was 5 (3-6) and at last follow-up was 4 (0-6). Based on these severity scales, 2 patients showed no change, 1 patient worsened, 1 patient completely resolved, and 4 patients had improvement regardless of initial extent of surgery or number of nuclei involved. CONCLUSION: This retrospective analysis compares thalamic tumor anatomical locations and treatment intervention with respect to movement disorder clinical characteristics and outcomes. Extent of location and surgical intervention did not correlate to severity and will be included in final presentation.
Allen's Test
Authors: Chethan Puttarajappa, Deepa S Rajan
Journal: New England Journal of Medicine (2010)

A 72-year-old man presented with a 3-week history of gradually worsening pain and bluish discoloration in his right index, middle, and ring fingers. He was a nonsmoker and reported having had no history of Raynaud's phenomenon, trauma, atrial fibrillation, or any invasive vascular procedure. The physical examination showed bluish discoloration of the distal phalanges and absent ulnar pulse in the right arm. A modified Allen's test was positive (video). Computed tomographic angiography confirmed occlusion of the right ulnar artery. The results of further evaluation with a hypercoagulable workup and transesophageal echocardiography were normal. The patient was treated with antiplatelet agents . . .
Mortality Associated with Nosocomial Urinary-Tract Infection
Authors: Richard Platt, B. Frank Polk, Bridget Murdock, Bernard Rosner
Journal: New England Journal of Medicine (1982)

In a prospective study, 131 of 1458 patients acquired 136 urinary-tract infections (defined as ≥105 colony-forming units per milliliter) during 1474 indwelling bladder catheterizations. Seventy-six patients (25 infected and 51 noninfected) died during hospitalization; death rates were 19 per cent in infected patients and 4 per cent in noninfected patients. Multiple logistic regression analysis demonstrated that seven of 21 prospectively monitored variables were associated with mortality among the catheterized patients. The adjusted odds ratio for mortality between those who acquired infection and those who did not was 2.8 (95 per cent confidence limits, 1.5 to 5.1). The acquisition of infection was not associated with the severity of underlying disease; among patients who died, infections occurred in 38 per cent of those classified as having nonfatal underlying disease (15 of 39) and in 27 per cent of those classified as having fatal disease (10 of 37). Twelve deaths may have been caused by acquired urinary-tract infections. Two patients had urinary-tract pathogens in premortem blood cultures. Another 10 died with clinical pictures compatible with serious infection, but no diagnostic cultures were performed. We conclude that the acquisition of urinary-tract infection during indwelling bladder catheterization is associated with nearly a threefold increase in mortality among hospitalized patients, but the reason for this association is not yet clear. (N Engl J Med. 1982; 307:637–42.)
Abstract 4060: Radiation-inducible silencing of uPA and uPAR <i>in vitro</i> and <i>in vivo</i> in meningioma
Authors: Venkateswara Rao Gogineni, Arun Kumar Nalla, Reshu Gupta, Bharathi Gorantla, Meena Gujrati, Dzung H. Dinh, Daniel Fassett, Jeffrey D. Klopfenstein, Jasti S. Rao
Journal: Cancer Research (2010)

Abstract Stereospecific radiation treatment offers a distinct opportunity for temporal and spatial regulation of gene expression at tumor sites by means of inducible promoters. To achieve this, a plasmid, pCArG-U2, was constructed by incorporating nine CArG elements (in tandem) of EGR1 gene upstream to uPA and uPAR siRNA oligonucleotides in a pCi-Neo vector. Radiation-induced siRNA expression was detected in a meningioma cell line (IOMM-Lee). Immunoblotting and RT-PCR analyses confirmed downregulation of uPA and uPAR. A similar effect was observed in transfected cells followed by H2O2 treatment. Moreover, pre-treatment of transfected cells with N-Acetyl L-Cysteine blocked the silencing of uPA and uPAR, which further confirmed the oxidative damage-mediated downregulation. Cell proliferation assays and western blot analysis for apoptotic molecules confirmed cell death in a radiation-inducible fashion. Migration and Matrigel invasion assays also revealed a marked decrease in the migration and invasive behavior. Immunocytochemistry showed a marked decrease in uPA and uPAR levels in the transfected and irradiated cells. H&amp;E staining revealed a decrease in the pre-established tumor volume among the animals treated with pCArG-U2 and radiation. Immunohistochemistry of the brain sections established with intracranial tumors also revealed a marked decrease in uPA and uPAR in a radiation-inducible fashion. Altogether, our data suggest pCArG-U2 as a suitable candidate for radiation-inducible gene therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4060.
Résultat du drainage trans digestif de collections intra-abdominales compliquant une pancréatite chez 26 malades
Authors: R Gerard, J Branche, J Boitard, P Bulois, P Desurmont, P Houcke, P Gillet, V Maunoury
Journal: Endoscopy (2011)

Introduction: Les modalités du drainage des collections intra-abdominales sus-mésocoliques symptomatiques et/ou présumées infectées, qui compliquent une pancréatite, sont discutées: chirurgicales, radiologiques ou endoscopiques et alors, par voie trandigestive, échoguidées ou non, ou par wirsungografie rétrograde.
Case 39-2004
Authors: Walter J. O'Donnell, Richard L. Kradin, A. Eden Evins, Conrad Wittram
Journal: New England Journal of Medicine (2004)

A 52-year-old woman was admitted to the hospital because of cough and dyspnea. She had had several hospitalizations for similar problems in the past decade. She was a long-term heavy smoker and had a schizoaffective disorder. Chest radiographs showed ground-glass opacities and increased interstitial markings and computed tomography of the chest showed a “crazy-paving pattern.” A diagnostic procedure was performed.
Value of endosonography for predicting risk of bleeding in cirrhotic patients with Portal Hypertensive Gastropathy
Authors: G de Stefano, C De Angelis, M de Stefano, A Di Sarno, N Farella, L De Luca, A Giorgio
Journal: Endoscopy (2011)

Aim: NIEC classification of Portal Hypertensive Gastropathy (PHG) (“mild” and “severe”) is not predictive of gastric haemorrhage. We studied the predictive value of Endosonography (EUS) for bleeding risk in patients (pts) with PHG and liver cirrhosis.
P2-01-09: Gene Expression Alterations in the Lymph Node Microenvironment in Response to Successful Metastatic Colonization.
Authors: RE Ellsworth, AL Valente, JL Kane, DL Ellsworth, CD Shriver
Journal: Cancer Research (2011)

Abstract Background: Breast stroma is known to play an active role in tumorigenesis, undergoing both phenotypic and molecular changes to facilitate and promote tumor development and growth. The metastatic microenvironment also plays a role in successful colonization; however, the genetic changes in these secondary microenvironments associated with metastasis are not well described. Methods: Women with invasive breast cancer with at least one lymph node with macrometastases and one lymph node with no detectable metastases were identified from the Clinical Breast Care Project. Lymph node tissue was microdissected from both the metastatic lymph node microenvironment and negative nodes and hybridized to U133A 2.0 gene expression arrays. Differential expression was detected using Partek® Genomics Suite™6.5 using a cutoff of P&amp;lt;0.001, &amp;gt;2-fold change. Results: Nineteen genes were differentially expressed between negative lymph nodes and lymph node tissue microdissected from lymph nodes with metastatic tumors. Eleven genes, including EPCAM, KRT19 and MUC1 were expressed at significantly higher levels in lymph node tissue from metastatic lymph nodes while eight genes, such as CXCL2 and CXCL5, were expressed at significantly higher levels in negative lymph nodes. Results have been validated in external sample sets for AZGP1, CLEC4M, CXCL2, EPCAM, MUC1, PIP and TFPI. Conclusions: Lymph node tissue differs in gene expression between those harboring metastatic tumors and those without metastasis. Genes expressed at higher levels in lymph nodes with macrometastases are involved in tumorigenesis, suggesting that like the breast stromal microenvironment, the metastatic microenvironment undergoes crosstalk with the tumor cells. In addition, a cluster of genes involved in immune function are expressed at lower levels in metastatic lymph nodes, suggesting that suppression of proper immune response may be required for successful metastatic colonization. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-01-09.
Malignant Nonepithelial Prostate Tumors
Authors: Aisheng Dong, Huojun Zhang, Yang Wang, Jing Gong, Changjing Zuo, Jijin Yang, Jianping Lu
Journal: Clinical Nuclear Medicine (2014)

The aim of this study was to evaluate F-FDG PET/CT findings of malignant nonepithelial prostate tumors and their correlation with MRI and CT images.FDG PET/CT findings were reviewed in 12 patients with malignant nonepithelial prostate tumor confirmed by pathology. The location, size, SUVmax, pathologic findings, and available MRI and CT images of the tumors were reviewed.Of the 12 patients (mean age, 41 years; age range, 19-66 years), 9 had normal prostate-specific antigen levels. The mean size of the tumors was 7.1 cm in diameter ranging from 4.6 to 10.5 cm. All the tumors showed increased metabolic activity with mean SUVmax of 17.5 ranging from 3.6 to 46.8. The high-grade malignant tumors tended to show higher FDG uptake, whereas the intermediate-grade and low-grade malignant ones tended to show lower FDG uptake. Seven tumors had local invasion or distant metastases. Lung was the most common metastatic site. On MRI, the tumors showed well-circumscribed or ill-circumscribed margins with inhomogeneous enhancement. On CT, the tumors showed hypodensity with slight to moderate enhancement.The malignant nonepithelial prostate tumors tended to have large sizes at presentation, have high FDG uptake, and affect a younger population with normal prostate-specific antigen levels. FDG PET/CT may be useful for the assessment of tumor grade and for detecting the distant metastases, whereas the MRI or enhanced CT may be more helpful for describing the relationship between the tumor and adjacent structures.
Abstract 3944: PTEN is not directly regulated by miRNA-21 in non-small cell lung cancer
Authors: Ioanna S. Sourvinou, Athina Markou, Loukas Kaklamanis, Emily G. Tsaroucha, Evi S. Lianidou
Journal: Cancer Research (2011)

Abstract Introduction: PTEN is a well known tumor suppressor gene that plays a crucial role in the regulation of many normal biological processes. Among the mechanisms taking part in its regulation has been demonstrated being miR-21 action, as it has been reported that PTEN consists one of miR-21 target genes. In this study, we speculated on the effect of miR-21 expression levels in non small cell lung cancer tissues towards: a) PTEN mRNA expression levels and b) PTEN protein levels. Materials and Methods: Thirty pairs of NSCLC fresh-frozen tissues and their corresponding noncancerous tissues were analyzed for the expression of mature miR-21 as well as for the expression of PTEN transcript using RT-qPCR. PBGD was used as a reference gene and for the evaluation of RNA quality in our samples. In parallel, PTEN protein levels were evaluated by immunohistochemistry in the same samples. Deparaffinized sections cut from paraffin-embedded tissue samples were stained with a specific anti-PTEN antibody. Tumor types and stages were determined according to the WHO classification. All samples were analyzed histologically to access the amount of tumor component (at least 70% of tumor cells) and the quality of material. Results: In 26/30 NSCLC tissues studied (86.7%), PTEN mRNA expression was decreased when compared to adjacent noncancerous tissues, while overexpression of PTEN transcript was perceived in only 4 samples (13.3%). Evaluation of PTEN protein level in these specimens revealed that in 28/30 samples (93.3%), PTEN protein was detected, while in only 2/30 samples (6.7%) PTEN protein loss was observed. The respective data for miR-21 expression levels indicated that PTEN mRNA as well as protein levels were independent of miR-21 expression status in non small cell lung cancer samples. Conclusion: Our data indicate for the first time that in NSCLC miR-21 expression levels do not directly regulate PTEN protein levels. PTEN protein was detected by IHC in the vast majority of NSCLC tissues despite the fact that PTEN mRNA expression levels were lower in cancerous tissues than in the corresponding noncancerous tissues. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3944. doi:10.1158/1538-7445.AM2011-3944
Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: a pooled analysis
Authors: Michael Kreuter, Wim Wuyts, Elisabetta Renzoni, Dirk Koschel, Toby M Maher, Martin Kolb, Derek Weycker, Paolo Spagnolo, Klaus-Uwe Kirchgaessler, Felix J F Herth, Ulrich Costabel
Journal: The Lancet Respiratory Medicine (2016)
SP0113 Innate lymphoid cells in the formation of lymphoid tissue
Authors: M. Coles
Journal: Annals of the Rheumatic Diseases (2013)

Lymphoid tissues have an essential role in the induction fo protective immune responses but paradoxically are commonly found associated with autoimmune disease pathology. Development of these tissues occurs as a result of interactions between different types of innate lymphoid cells and underlying mesenchyme which develops into the stroma that supports B and T cell survival. In this lecture comparison between mechanisms driving the development and organisation of different lymphoid tissues including lymph nodes, tonsils, spleen and Peyer’s patches will be discussed. Through understanding the etiology of both normal and pathological tissue formation and organisation novel therapeutics can be developed that selectively modulate the function of lymphoid tissues. <h3>Disclosure of Interest</h3> None Declared
Preoperative and Postoperative Lymphoscintigraphy Using Tc-99m Sulfur Colloid in the Repair of a Lymphatic Leak in a Patient with Traumatic Chylothorax
Authors: SHUNG-SHUNG SUN, SHIH-CHUAN TSAI, NAN-YUNG HSU, CHIH-SHIUN SHIH, JONG-KANG LEE, CHIA-HUNG KAO
Journal: Clinical Nuclear Medicine (2000)

Lymphoscintigraphy can identify abnormal lymphatic leakage and drainage in chyluria, chyloperitoneum, and chylothorax. It is a physiologic, fast, and noninvasive method and has no known adverse effects. A 19-year-old man had a massive left pleural effusion after trauma, and draining fluid was found to be chylous. Preoperative and postoperative lymphoscintigraphy were performed after subcutaneous injection of Tc-99m sulfur colloid into the first–second and fourth–fifth interdigital spaces of both feet and using a large-field-of-view gamma camera fitted with a low-energy, general purpose collimator. Preoperative lymphoscintigraphy showed abnormal focal tracer accumulation in the left subclavicular region close to the mediastinum and diffusely increased tracer uptake in the left lung field approximately 1 hour after injection. The thoracic duct was surgically ligated, and follow-up postoperative lymphoscintigraphy showed no abnormal tracer accumulation at the previously abnormal sites.
FRI0082 Radiographic progression in rheumatoid arthritis in the 21st century
Authors: M. Gärtner, F. Alasti, G. Supp, J. Smolen, D. Aletaha
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Progression of joint damage as measured radiographically is a hallmark of rheumatoid arthritis (RA), and its reduction a key claim for traditional and novel antirheumatic drugs. Data from clinical trials may be interpreted to indicate that the observed progression of RA (in comparator groups of clinical trials) has decreased over the past two decades.<sup>1</sup> Although these observations mainly stem from clinical trials, it has been hypothesized that RA may have become a less destructive disease. <h3>Objectives</h3> To evaluate the frequency as well as the level of radiographic progression in real life routine RA patients in the 21<sup>st</sup> century. <h3>Methods</h3> RA patients of our outpatient clinic, who had two x-rays performed over a three to five year interval between the years 2000 and 2012 were included. X-rays of the hands and feet were scored according to the Sharp van der Heijde (SvdH; range 0-448) method.<sup>2</sup> Clinical and demographic data were collected from the patients' charts. Disease activity was assessed using the clinical disease activity index (CDAI-average over time). Patients were separated into three periods of time (2000-2004, 2005-2008, 2009-2012) and the annual radiographic progression was calculated based on the observed progression in these periods. The mean number of joints with radiographic progression per patient, as well as the mean grade of progression per joint (erosion/joint space narrowing, JSN) were evaluated. Lack of progression was defined as no progression in total SvdH. <h3>Results</h3> Of the 444 patients included (mean duration of RA 7.4±9.4 years, 56.2% rheumatoid factor positive, 62.0% ACPA positive), 406 (91.4%) showed radiographic progression over a mean of 3.8±0.6 years. In all progressors we found no difference in rates of total radiographic progression, erosion score, or JSN, the three different time periods (Table 1). <h3>Conclusions</h3> Only a minority of patients did not progress structurally over three to five years. The temporal trend analysis indicates that on the background of similar average disease activity and mixed treatment, the overall annual progression was constant during the last decade. However, in general progression of joint damage was low. <h3>References</h3> Rahman MU et al. <i>Ann Rheum Dis</i> 2011; 70(9):1631-1640. van der Heijde D. <i>J Rheumatol</i> 1999; 26(3):743-745. <h3>Disclosure of Interest</h3> None Declared
Abstract 800: Formation of chemotherapy resistance-inducing fatty acids by mesenchymal stem cells depends on COX-1, thromboxane synthase and intracellular calcium
Authors: Julia M. Houthuijzen, Jeanine M.L. Roodhart, Laura G.M. Daenen, Emile E. Voest
Journal: Cancer Research (2012)

Abstract The development of resistance to chemotherapy is considered to be one of the most important obstacles to continued effective treatment of cancer in patients. We recently have identified an important mechanism that is responsible for systemic resistance to chemotherapy. Circulating mesenchymal stem cells (MSCs) activated by chemotherapy secrete specific polyunsaturated fatty acids that confer resistance to a broad spectrum of anti-cancer agents. These factors were identified to be two distinct platinum-induced polyunsaturated fatty acids (PIFAs) 12-S-keto-5,8,10-heptadecatrienoic acid (KHT) and 4,7,10,13-hexadecatetraenoic acid (16:4(n-3)) that were able to induce chemotherapy resistance in picomolar concentrations. Interestingly, the production of these PIFAs is restricted to MSCs and mouse embryonic fibroblasts (MEFs), other stem cells like hematopoietic stem cells and cancer stem cells are not able to form the PIFAs after cisplatin stimulation. Research from our lab showed that the production of these PIFAs can be blocked by cyclooxygenase-1 (COX-1), thromboxane A synthase (TXAS) and intracellular calcium inhibitors, suggesting that these are important in the production of the PIFAs, and indicating that the PIFAs are formed in the pathways of arachidonic acid (AA) and eicosapentaenoic acid (EPA). Lipid peroxidation with subsequent release of oxygen radicals could be a trigger for the formation of PIFA. We therefore tested whether reactive oxygen species (ROS) were involved in the production of the PIFAs. Neither increasing ROS by hydrogen peroxide, nor scavenging of ROS by glutathione in the MSCs influenced the level of resistance to chemotherapy in mice. In addition, intracellular ROS levels in the MSCs treated with cisplatin for various intervals did not change as was determined by DCFDA fluorescence. Our findings provide a new paradigm on how MSCs can induce a systemic protection against chemotherapy through the secretion of two distinct fatty acids that are formed in response to platinum-containing chemotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 800. doi:1538-7445.AM2012-800
THE IMPORTANCE OF THE LEAFLET-TO-ANNULAR MISMATCH INDEX FOR PATIENTS UNDERGOING ECHO GUIDED TRANSAPICAL OFF-PUMP MITRAL VALVE REPAIR WITH NEOCHORD IMPLANTATION
Authors: Andrea Colli, Matteo Montagner, Danila Azzolina, Nicola Soriani, Laura Besola, Erica Manzan, Eleonora Bizzotto, Fabio Zucchetta, Roberto Bellu, Demetrio Pittarello, Gino Gerosa
Journal: Journal of the American College of Cardiology (2016)