tbuckley/cabot-search huggingface dataset:
Abstract 5456: The E3 ubiquitin ligase Siah2 regulates the androgen receptor activity and contributes to castration-resistant prostate cancer.
Authors: Jianfei Qi, Manisha Tripathi, Natasha Sahgal, Ladan Fazil, Susan Ettinger, William J. Placzek, Giuseppina Claps, Leland W.K. Chung, David Bowtell, Martin Gleave, Neil Bhowmick, Ze'ev Ronai
Journal: Cancer Research (2013)

Abstract The androgen receptor (AR) plays a central role in the development of castration-resistant prostate cancer (CRPC), which is a major challenge for hormone therapy of advanced/metastatic prostate cancer (PCa). Here, we demonstrate that the ubiquitin ligase Siah2 targets a select pool of NCOR1-bound, transcriptionally inactive AR for ubiquitination-dependent degradation, and this promotes the subsequent recruitment of p300-bound, transcriptionally active AR to a select group of AR target gene promoters/enhancers. Consequently, Siah2 promotes the expression of ∼13% of androgen-responsive genes involved in lipid metabolism, cell motility and proliferation. The Siah2 binding sites located within the AR ligand-binding domain are mutated in PCa, resulting in attenuation of Siah2-mediated regulation. Siah2 is required for growth of PCa cells under the androgen-deprivation condition in vitro and in vivo. Significantly, inhibition of Siah2 promotes PCa regression upon castration and Siah2 expression is markedly increased in human CRPCs. Collectively our findings identify a key role for Siah2 in CRPC through the selective regulation of AR transcriptional activity. Citation Format: Jianfei Qi, Manisha Tripathi, Natasha Sahgal, Ladan Fazil, Susan Ettinger, William J. Placzek, Giuseppina Claps, Leland W.K. Chung, David Bowtell, Martin Gleave, Neil Bhowmick, Ze'ev Ronai. The E3 ubiquitin ligase Siah2 regulates the androgen receptor activity and contributes to castration-resistant prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5456. doi:10.1158/1538-7445.AM2013-5456 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Ultrasonic Tissue Characterization of Pancreatic Disease
Authors: Zhang MinMin, Yang Hua, Jin ZhenDong, Li ZhaoShen
Journal: Endoscopy (2011)

Ultrasound is a widely used medical imaging modality due to its versatility, relative safety, low cost and the availability of portable units. Ultrasonograms (USGs) are in various gray levels (though new machines give red and blue colors for blood flows). Human observers are good at extracting information relating to brightness and contrast but not to second-order textural analysis which has been found to be very useful in clustering ultrasound images. Second- and higher-order statistics, e.g. co-occurrence matrix and its derivatives, however demand heavy computational resources which impose disadvantages to automation. In USG, tissue is often modeled as a collection of point scatterers, embedded in a uniform non-scattering medium. Considering inherent biological variabilities, the spatial distribution and scattering strengths (scattering cross-sections) of these scatterers are usually described in statistical terms. The speckle pattern of an ultrasound image depends on the ultrasound scanner used for imaging, and to a certain degree, on the distribution of scattering elements which is inherently related to the tissue type in medical ultrasound. So, here comes the need of ultrasonic tissue characterization (UTC).
Local Allergic Rhinitis is Highly Prevalent in a Population Attended for the Evaluation of Rhinitis
Authors: C. Rodon Segovia, P. Campo Mozo, L. Galindo Reyes, G. Campos, J.L. Rodriguez-Bada, C. De Leyva, M.J. Torres Jaen, M. Blanca Gomez
Journal: Journal of Allergy and Clinical Immunology (2012)
CS-11 * AN RNAi KINOME SCREEN OF GLIOBLASTOMA STEM CELLS UNDER NORMOXIA AND HYPOXIA
Authors: S. Goel-Bhattacharya, S. Kulkarni, S. Sengupta, S. Khagi, B. Cochran
Journal: Neuro-Oncology (2014)

Glioblastoma stem like cells are known to have phenotypes and gene expression patterns distinct from traditional glioma cell lines grown in serum. They also may have increased resistance to drugs and radiation and are likely to be responsible for tumor recurrence following therapy. As a result, it is important to identify therapeutic targets for these cells. To do this, we have conducted RNAi screens in glioblastoma stem cells against the human kinome since kinases are druggable targets and many kinase inhibitors are known. In addition, glioblastomas often have significant regions of hypoxia and glioblastoma stem cells tend to be resistant to hypoxia. We have therefore conducted shRNA screens in both normoxic and hypoxic conditions. We have screened 2 independent cell lines to date and are working on others. Defining a hit as a gene that has at least 2 independent shRNAs that give at least 50% growth inhibition as compared to controls, we found that 79 and 84 of (501 kinase genes) are hits under either normoxia or hypoxia for the GS6-22 and GS7-2 stem-like cell lines, respectively. We found that 56 and 63 kinases were hits under both conditions. 15 and 16 genes gave preferential inhibition under normoxia and 8 and 4 genes preferentially inhibited under hypoxia. 31 kinases were inhibitory in both cell lines. Thus, there is considerable variation between cell lines. Several of the identified hits are well known to have a role in glioblastoma such as EGFR and CDK4, and were inhibitory in both cell lines. About a third of the hits have previously been implicated in glioblastoma. One of the hits we have independently validated is the SMG1 kinase is preferentially inhibitory in hypoxia in only one of the cell lines. Together, these data give support to the idea of developing personalized therapies for glioblastoma.
Abstract 5337: MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion.
Authors: Jessica Bockhorn, Kathy Yee, Ya-Fang Chang, Aleix Prat, Dezheng Huo, Chika Nwachukwu, Rachel Dalton, Simo Huang, Kaitlin E. Swanson, Charles M. Perou, Olufunmilayo I. Olufunmilayo, Michael F. Clarke, Huiping Liu, Geoffrey Greene
Journal: Cancer Research (2013)

Abstract Metastasis remains a significant challenge in treating cancer. MicroRNAs have emerged as important epigenetic regulators of various cellular processes during cancer development and progression. The goal of this study was to characterize signaling pathways for miRNA biomarkers that regulate breast cancer metastasis. Here we show that human breast tumor biomarker miR-30c regulates invasion by targeting the cytoskeleton network genes encoding Twinfilin 1 (TWF1) and Vimentin (VIM). Both VIM and TWF1 have been shown to regulate epithelial-to-mesenchymal transition (EMT). Similar to TWF1, VIM also regulates F-actin formation, a key component of cellular transition to a more invasive mesenchymal phenotype. To further characterize the role of the TWF1 pathway in breast cancer, we found that IL-11 is an important target of TWF1 that regulates breast cancer cell invasion and STAT3 phosphorylation. This miR-30c VIM/TWF1-IL11-pSTAT3 pathway will expedite the development of targeting strategies to prevent and treat breast tumor progression. Citation Format: Jessica Bockhorn, Kathy Yee, Ya-Fang Chang, Aleix Prat, Dezheng Huo, Chika Nwachukwu, Rachel Dalton, Simo Huang, Kaitlin E. Swanson, Charles M. Perou, Olufunmilayo I. Olufunmilayo, Michael F. Clarke, Huiping Liu, Geoffrey Greene. MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5337. doi:10.1158/1538-7445.AM2013-5337
Fungal Flora of the Normal Human Small and Large Intestine
Authors: R. Cohen, F. J. Roth, E. Delgado, D. G. Ahearn, M. H. Kalser
Journal: New England Journal of Medicine (1969)

Cultures of 86 specimens (including 23 oropharyngeal, 26 jejunal, 20 ileal and 17 fecal samples in 27 normal adults showed Candida albicans to be the most frequent fungus in high concentrations in all areas sampled. Both the frequency and concentration of C. albicans increased progressively from the oropharynx to the colon: 30 per cent in the oropharynx, 54 per cent in the jejunum, 55 per cent in the ileum and 65 per cent in the fecal specimens. C. albicans, in concentrations of 102 colonies per milliliter or greater, were encountered in 27 per cent of oropharyngeal, 43 per cent of jejunal, 50 per cent of ileal and 59 per cent of colonie specimens. The stability of the mycofloral pattern of the small intestine was demonstrated in five subjects who were resampled five to nine months after the initial studies; the fungal pattern was qualitatively and quantitatively unchanged.
Far East's Cancer Mortality Patterns Shift, Reflecting Cultural Changes
Authors: H. McIntosh
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Far East's Cancer Mortality Patterns Shift, Reflecting Cultural Changes Get access Hugh McIntosh Hugh McIntosh Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 14, 15 July 1992, Pages 1069–1071, https://doi.org/10.1093/jnci/84.14.1069 Published: 15 July 1992
Hypercalcemia of Sarcoid Corrected with Cortisone
Authors: Roswell W. Phillips
Journal: New England Journal of Medicine (1953)

THE course of Boeck's sarcoid is characteristically said to be benign.1 However, significant impairment of vital organs is not uncommon. Most frequently noted are eye involvement, which may lead to diminished vision or blindness,2 and pulmonary lesions resulting in fibrosis of lung parenchyma, pulmonary insufficiency and cor pulmonale.3 A less emphasized abnormality in sarcoidosis is hypercalcemia and its attendant dangers to the patient. In the following case, reversal of hypercalcemia was accomplished with cortisone.Case ReportA 28-year-old man had fever, migratory joint pain and red nodular lesions of the skin of the anterior surface of both legs in May, . . .
Cyclophosphamide Therapy of Severe Systemic Necrotizing Vasculitis
Authors: Anthony S. Fauci, Paul Katz, Barton F. Haynes, Sheldon M. Wolff
Journal: New England Journal of Medicine (1979)

We studied 17 patients with severe systemic necrotizing vasculitis over an 11-year-period. Sixteen patients were treated daily with cyclophosphamide (2 mg per kilogram per day), and one was treated with azathioprine (2 mg per kilogram per day). Before entering the study, all patients had active and progressive disease, even though 16 patients had been receiving corticosteroids that had caused severe and often incapacitating toxic side effects. Three patients died during the study. Complete and often dramatic remissions occurred in the surviving 14 patients, who were then placed on alternate-day corticosteroid treatment with continuation of cyclophosphamide. Corticosteroids were later discontinued in seven patients. The mean duration of remission was 22 months (range, two to 61). No patient showed recurrence of disease during treatment with cytotoxic agents.
Small-intestinal hemorrhage caused by treatment with sorafenib for hepatocellular carcinoma and diagnosed by capsule endoscopy
Authors: Y. Takahashi, S. Fukunishi, T. Nishikawa, S. Nouda, Y. Sasaki, M. Sanomura, E. Umegaki, K. Higuchi
Journal: Endoscopy (2013)

Sorafenib, a multikinase inhibitor, is the first-line treatment for unresectable progressive hepatocellular carcinoma (HCC) and has been approved by both the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) [1] [2]. Although there are studies reporting its effectiveness, there are also reports about adverse events related to treatment with this drug. Among the noted side effects is gastrointestinal hemorrhage, although only a few studies have reported the frequency of this complication [3] [4]. This is the first case report of small-intestinal hemorrhage following sorafenib treatment, and includes a description of the finding of hemorrhagic lesions as determined by capsule endoscopy.
Endoscopic mucosal resection of laterally spreading lesions involving the ileocecal valve: technique, risk factors for failure, and outcomes
Authors: Kavinderjit Nanda, Nicholas Tutticci, Nicholas Burgess, Rebecca Sonson, Stephen Williams, Michael Bourke
Journal: Endoscopy (2015)

<b>Background and study aims:</b> Endoscopic mucosal resection (EMR) of laterally spreading lesions (LSLs) involving the ileocecal valve (ICV) is technically demanding. Conventionally, these lesions are considered too challenging for endoscopic therapy and are primarily managed surgically. The aims of the study were to describe effectiveness, safety, and outcomes following EMR of LSLs at the ICV. <b>Patients and methods:</b> This was a single-center, prospective, observational, cohort study performed at an academic, tertiary referral center. Patients undergoing EMR for LSLs ≥ 20 mm involving the ICV were recruited over a 5-year period. Standard or cap-assisted colonoscopy with inject-and-resect EMR technique was performed with standardized post-EMR management. Procedural success, safety, and outcomes compared with non-ICV LSLs managed during the same period were analyzed. <b>Results:</b> A total of 53 patients with ICV LSLs were referred for EMR (median age 69 years; median lesion size 35.0 mm; 52.8 % females). Six patients went directly to surgery because of an endoscopic diagnosis of malignancy (n = 2) or technical failure of EMR (n = 4). EMR achieved complete adenoma clearance in 44 out of 47 attempted (93.6 %). Surgery was ultimately avoided in 43/53 (81.1 %). Complications included bleeding in 6.4 %. There were no perforations or strictures. Early adenoma recurrence was detected in 7/40 patients (17.5 %), and 1/22 (4.5 %) had late recurrence. All were successfully managed endoscopically. Factors associated with failure of ICV EMR were ileal infiltration and involvement of both ICV lips. <b>Conclusions:</b> In the majority of cases, LSL involving the ICV can be effectively treated by EMR on an outpatient basis. In specialized centers, complications are infrequent, and > 80 % of patients ultimately avoid surgery. Trial registered at ClinicalTrials.gov (NCT01368289).
LESION LOCALIZATION ON SPECT IMAGING IN HEMISPATIAL NEGLECT
Authors: F. S. Leibovitch, S. E. Black, C. B. Caldwell, A. R. McIntosh, J. P. Szalai
Journal: Clinical Nuclear Medicine (1998)

Leibovitch, F. S.*; Black, S. E.*; Caldwell, C. B.*; McIntosh, A. R.+; Szalai, J. P.* Author Information
Wilfred Ernest Chapman
Authors: R. Catty
Journal: BMJ (2012)

Wilfred Chapman (“Wilf”) was born and bred in Durham and worked there for most of his life. From the Durham Johnston Grammar School he went to Newcastle to study medicine. Having worked in orthopaedics he joined the Royal Air Force in 1942 and became medical officer to an Australian fighter squadron before serving in Normandy and onwards into Germany. After being demobbed in 1946 he …
ES8-1: Breast Reconstruction with Implants and Post-Mastectomy Irradiation: Algorithm and Outcomes.
Authors: PG Cordeiro
Journal: Cancer Research (2011)

Abstract Breast reconstruction in the face of radiotherapy proposes a unique set of challenges to the plastic surgeon and often alters the algorithm of the reconstruction. The impact of radiation changes on the alloplastic breast reconstruction is unpredictable. The author will review current approaches to reconstruction of the patient if they are to undergo post-mastectomy radiation. The algorithm for reconstruction and outcomes after radiation will be presented. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr ES8-1.
Levonorgestrel Intrauterine System — First-Line Therapy for Heavy Menstrual Bleeding
Authors: Eve Espey
Journal: New England Journal of Medicine (2013)

Heavy menstrual bleeding, or menorrhagia, affects up to 30% of women during their reproductive years, negatively affecting their quality of life1,2 and exacting a high price from the health care system.3 Several studies have assessed the effectiveness and cost-effectiveness of various medical and surgical therapies,46 but a clearly superior approach to management of heavy menstrual bleeding remains elusive.In this issue of the Journal, Gupta et al.7 provide data from a multicenter, randomized, controlled trial showing the superiority of the levonorgestrel intrauterine system (levonorgestrel-IUS) over other usual medical treatments in improving quality of life for women who sought . . .
THU0345 Similarities between fibromyalgia and chronic fatigue syndrome: A single disease?:
Authors: J. Rivera, A. Collado, J. Alegre, J. Blanch, J. Vidal, A. Arias, J. Carbonel
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) are considered two different entities. The clinical criteria used for the diagnosis do not permit to understand the true relationship between them, although they share many similar demographic and clinical aspects (1). For example: it is known that FM is a disease with extensive involvement of the nociceptive system with a significant number of tender points. However, recent studies have also shown similar findings in CFS (2). <h3>Objectives</h3> The aim of our study is to analyze the clinical differences between these two entities in a large sample of patients. <h3>Methods</h3> A total of 2007 patients and 398 healthy family controls were studied in different specialized units in FM and/or CFS in Spain. 1374 patients met the 1990 ACR criteria for the diagnosis of FM (women 97%, mean age 49,3±10,08 years), 396 patients fulfilled theFukuda criteria for CFS (women 84%, mean age 45,44±11,85 years) and 241 patients met both sets of criteria (women 92%, mean age 47,23±10,65 years). All patients and controls were studied for demographic variables, personal and family history, clinical symptoms, comorbidities, health status and standardized test sensitivities. <h3>Results</h3> Results: The main findings are show in the table. <h3>Conclusions</h3> The findings suggest a single process with a different stage of evolution from lower to higher severity in FM, SFC and FM-SFC, respectively. In CFS patients without FM criteria, there is a high proportion of men and have more comorbid psychopathology. Also in these patients, there are a great number of neurovegetative or immunological symptoms.There were no significant differences in the remaining variables studied, with the exception of tender points which were used as a classification criterion. <h3>References</h3> Dedra Buchwald. Rheum Dis Clin North Am. 1996 May;22(2):219-43 Meeus M, Nijs J, Huybrechts S, Truijen S. Clin Rheumatol. 2010 Apr;29(4):393-8 <h3>Disclosure of Interest</h3> None Declared
Use of Cardiac Procedures and Outcomes in Elderly Patients with Myocardial Infarction in the United States and Canada
Authors: Jack V. Tu, Chris L. Pashos, C. David Naylor, Erluo Chen, Sharon-Lise Normand, Joseph P. Newhouse, Barbara J. McNeil
Journal: New England Journal of Medicine (1997)

Acute myocardial infarction is a leading cause of morbidity and mortality in the United States and Canada. We performed a population-based study to compare the use of cardiac procedures and outcomes after acute myocardial infarction in elderly patients in the two countries.
A3.19 mIR-193B induces UPA in SSC and contributes to the proliferative vasculopathy via uPAR independent pathways
Authors: Naoki Iwamoto, Serena Vettori, Britta Maurer, Matthias Brock, Astrid Jüngel, Maurizio Calcagni, Renate E. Gay, Jörg H. W. Distler, Steffen Gay, Atsushi Kawakami, Oliver Distler
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> We had reported that miRNA-193b (miR-193b) is significantly downregulated in SSc and that down regulation of miR-193b causes overproduction of urokinase type plasminogen activator (uPA). However, the effects of increased levels of uPA may be limited in SSc because of inactivation of the cellular receptor for uPA (uPAR) after cleavage by matrix metalloproteinase-12. <h3>Objective</h3> To investigate whether the effects of uPA in SSc are mediated by uPAR independent pathways. <h3>Methods:</h3> Expression of miR-193b in SSc skin fibroblasts and skin sections from SSc were analysed by Real-time PCR. Transfection with miR-193b precursor and inhibitor were used to identify targets of miR-193b. Basal expression and localisation of uPA were examined by Real-time PCR, Western blot and immunohistochemistry. Furthermore, human pulmonary artery smooth muscle cells (HPASMCs) were treated with uPA and the proliferative effects of uPA were determined by WST-1 assay and by analysis of proliferating cell nuclear antigen expression. FACS was performed to investigate the effect of uPA on apoptosis. For inhibition of the uPA-uPAR pathway, uPAR neutralising antibodies, siRNA against uPAR and low molecular weight uPA, which does not bind to uPAR, were used. <h3>Results</h3> MiR-193b was significantly down regulated in SSc fibroblasts (n = 12) as compared with healthy controls (HC) (n = 6) (31 ± 33%, p&lt;0.01). In addition, miR-193b was also reduced in SSc skin sections (n = 5) as compared with HC (n = 5) (54 ± 16%, p&lt;0.005). Induction of miR-193b in SSc fibroblasts suppressed the production of uPA protein and the expression of uPA mRNA. Conversely, knockdown of miR-193b increased the level of uPA expression. Under TGF-b stimulation, the expression of uPA in SSc fibroblasts was upregulated as compared with HC (x-fold induction: 8.5 ± 3.9, P&lt;0.05). uPA was expressed preferentially in vessel in SSc skin sections. Interestingly, uPA induced cell proliferation (121 ± 23.8%, P&lt;0.05) and inhibited apoptosis (by 66 ± 3.9%, P&lt;0.05) in HPASMCs. Even in the presence of uPAR neutralizing antibodies or after silencing of uPAR by siRNA, uPA effectively inhibited apoptosis (80 ± 6.4% and 82 ± 19.2% respectively, P&lt;0.05 both). Finally, low-molecular uPA also inhibited apoptosis significantly (79 ± 5.9%, P&lt;0.05) confirming the results with neutralizing antibodies and siRNA. <h3>Conclusion</h3> Our results suggest that the down regulation of miR-193b in SSc induces expression of uPA, which leads to increased numbers of vascular smooth muscle cells via uPAR independent pathways and thereby contributes to the proliferative vasculopathy characteristic of SSc. This is the first link between miRNA dysregulation and vasculopathy in SSc.