tbuckley/cabot-search huggingface dataset:
Lisinopril and Kaposi's sarcoma
Authors: A. Di Carlo
Journal: British Journal of Dermatology (2004)

Journal Article Lisinopril and Kaposi's sarcoma Get access A. Di Carlo A. Di Carlo STD Service, S Gallicano Institute, IRCCS, Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 1, 1 January 2004, Pages 158–159, https://doi.org/10.1111/j.1365-2133.2004.05746.x Published: 01 January 2004
Prolonged survival of neutrophils from patients with F508 CFTR mutations
Authors: D J McKeon, A M Condliffe, A S Cowburn, K C Cadwallader, N Farahi, D Bilton, E R Chilvers
Journal: Thorax (2008)

When thunderstorms were stratified by wind gust levels, associations with asthma were strongest when wind gusts were intermediate and high.Our findings corroborate previous reports of an association of thunderstorm activity with asthma exacerbation.Furthermore, our results provide preliminary evidence in support of rainfall and wind gusts playing important roles in this association.While a 3% increase in risk may seem modest, asthma is quite prevalent in Atlanta and a modest relative increase could have a significant public health impact in the population.This analysis used meteorological data from one weather station.However, thunderstorms are small scale phenomena, and these data may only represent events in close proximity to the station.Planned analyses will take advantage of data from other local stations, radar data on thunderstorm characteristics and spatial resolution of the outcome data to conduct a more refined assessment of the mechanistic basis of the observed association.
Abstract 3411: Targeting of EWS-FLI1 with small molecule YK-4-279 reduces xenograft growth by disruption of disordered protein-protein interactions
Authors: Jeffrey A. Toretsky, Hayriye V. Erkizan, Yali Kong, Melinda Merchant, Julie S. Barber-Rotenberg, Milton L. Brown, Aykut Üren
Journal: Cancer Research (2010)

Abstract Introduction: EWS-FLI1 oncoprotein is expressed as a result of a tumor-specific translocation that occurs in patients with Ewing's Sarcoma. Development of strategies to therapeutically target EWS-FLI1 revealed its significant intrinsically disordered regions. The intrinsically disordered regions enhance protein-protein interactions while presenting an opportunity for small molecule targeting. We hypothesized that a small molecule could bind to EWS-FLI1 and prevent a key protein-protein interaction with RNA Helicase A (RHA) leading to decreased cell growth. Methods: Small molecule library screening was performed using surface plasmon resonance. Chemical optimization followed by fluorescence polarization enhanced and confirmed compound binding to EWS-FLI1, respectively. Testing of compounds included co-immunoprecipitation, cell growth, caspase-3, and xenografts. Results: A library of 3000 compounds (NCI, DTP) was screened for EWS-FLI1 binding. NSC635437 had an RUactual: RUtheorhetic of 0.9 and was chosen for further evaluation based upon potential for chemical derivatization. One optimized compound, YK-4-279, significantly reduced the protein-protein interaction between EWS-FLI1 and GST-RHA(647-1075). SPR measurement of the KD was 9.48 microM for the affinity of YK-4-279 with EWS-FLI1. YK-4-279 has an IC50 of 1 microM for a series of ESFT cell lines, while cell lines that lack EWS-FLI1 are 10-30 fold more resistant to the compound. YK-4-279 reduced the growth of Ewing's Sarcoma xenografts while not affecting the growth of PC3 prostate tumors. PONDR analysis of EWS-FLI1 and RHA indicate that their interaction is occurring in an ordered-disordered transition region of RHA. Conclusions: The lead compound derivative YK-4-279 demonstrates that the EWS-FLI1/RHA interaction can be blocked with a detrimental effect on Ewing's Sarcoma cells both in vitro and in vivo. These findings both validate the interaction of EWS-FLI1 with RHA as an oncogenic target and provide a lead compound for therapeutic development. Additional studies are underway to evaluate the contributions of the disordered regions to small molecule binding and developing strategies of optimization. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3411.
Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites
Authors: Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks, Jennifer R. Grandis, David Sidransky, Nils Erik Heldin, Jeffrey N. Myers
Journal: Clinical Cancer Research (2011)

Abstract Purpose: Human cell lines are useful for studying cancer biology and preclinically modeling cancer therapy, but can be misidentified and cross-contamination is unfortunately common. The purpose of this study was to develop a panel of validated head and neck cell lines representing the spectrum of tissue sites and histologies that could be used for studying the molecular, genetic, and phenotypic diversity of head and neck cancer. Methods: A panel of 122 clinically and phenotypically diverse head and neck cell lines from head and neck squamous cell carcinoma, thyroid cancer, cutaneous squamous cell carcinoma, adenoid cystic carcinoma, oral leukoplakia, immortalized primary keratinocytes, and normal epithelium was assembled from the collections of several individuals and institutions. Authenticity was verified by carrying out short tandem repeat analysis. Human papillomavirus (HPV) status and cell morphology were also determined. Results: Eighty-five of the 122 cell lines had unique genetic profiles. HPV-16 DNA was detected in 2 cell lines. These 85 cell lines included cell lines from the major head and neck primary tumor sites, and close examination shows a wide range of in vitro phenotypes. Conclusions: This panel of 85 genomically validated head and neck cell lines represents a valuable resource for the head and neck cancer research community that can help advance understanding of the disease by providing a standard reference for cell lines that can be used for biological as well as preclinical studies. Clin Cancer Res; 17(23); 7248–64. ©2011 AACR.
Increased Incidence of Squamous Cell Carcinoma of Eye After Kidney Transplantation
Authors: C. M. Vajdic, M. T. van Leeuwen, S. P. McDonald, M. R. E. McCredie, M. Law, J. R. Chapman, A. C. Webster, J. M. Kaldor, A. E. Grulich
Journal: JNCI Journal of the National Cancer Institute (2007)

Squamous cell carcinoma (SCC) of the eye occurs at substantially increased rates in individuals with human immunodeficiency virus (HIV) infection, but it has not been reported in individuals with iatrogenic or congenital immune deficiency. In a national, population-based cohort of 10,180 renal transplantation patients from Australia with 86,898 person-years of follow-up, we ascertained primary incident cancers diagnosed in 1982-2003 by record linkage between the Australia and New Zealand Dialysis and Transplant Registry and the Australian National Cancer Statistics Clearing House. Standardized incidence ratios (SIRs) of cancer were calculated using age-, sex-, calendar year-, and state/territory-specific population cancer incidence rates. Statistical tests were two-sided. Five patients were diagnosed with ocular SCC after kidney transplantation (0.26 were expected), and the incidence was increased 20-fold (SIR = 19.5, 95% confidence interval [CI] = 6.3 to 45.5). Compared with the entire cohort, the five patients with ocular SCC after transplantation were more likely to have resided in the subtropical state of Queensland (60% versus 17%, P = .04), to have had end-stage kidney disease as a result of glomerulonephritis (100% versus 46%, P = .02), and to have a history of cutaneous SCC (100% versus 29%, P = .002). The increased incidence of ocular SCC after kidney transplantation and after HIV infection strongly suggests that this neoplasm is an immune deficiency-associated cancer. Our data also support an interaction between immune suppression and sun exposure in the development of ocular SCC after kidney transplantation.
Sarcoidosis-related pulmonary veno-occlusive disease presenting with recurrent haemoptysis
Authors: R. M. Jones, A. Dawson, G. H. Jenkins, A. G. Nicholson, D. M. Hansell, N. K. Harrison
Journal: European Respiratory Journal (2009)

To the Editors: 

A 52-yr-old female nonsmoker presented with haemoptysis consisting of streaks of bright red blood daily for 3 weeks. She gave a 3-yr history of dry cough, episodic wheeze and mild exertional dyspnoea. The symptoms had not improved with inhaled corticosteroids (fluticasone 250 μg b.i.d ). The patient denied fever, sweats or weight loss and had no significant past medical history. Physical examination was unremarkable. Chest radiograph showed no focal pulmonary abnormality or obvious lymphadenopathy, and electrocardiogram was normal. Pulmonary function tests recorded a forced expiratory volume in 1 s (FEV1) of 2.22 L (86% predicted), a forced vital capacity (FVC) of 2.93 L (96% pred) and a diffusing capacity of the lung for carbon monoxide ( D L,CO) of 7.23 mmol·m−1·kPa−1 (88% pred).

Laboratory investigations showed a haemoglobin level of 12.9 g·dL−1, and a normal coagulation screen, metabolic screen and erythrocyte sedimentation rate (21 mm·h−1). Serum auto-antibodies were negative and the angiotensin converting enzyme (ACE) level was 53 IU·L−1 (normal range 0–52 IU·L−1). High-resolution computed tomography (HRCT) of the chest showed thickening of central bronchovascular bundles and scattered, nodular, ground-glass and airspace opacities (fig. 1a⇓). Fibreoptic bronchoscopy was requested. At 1 h prior to the procedure, the patient had a large haemoptysis of 200 mL bright red blood. Bronchoscopy showed diffuse fresh blood and grossly hyperaemic bronchial mucosa with generalised oozing from major and lobar bronchi (fig. 1b⇓).



Fig. 1— 
a) Axial high-resolution computed tomography (HRCT) image showing nodular thickening extending along central bronchovascular bundles in the apical segment of the left lower lobe. Elsewhere, there were scattered nodular, ground-glass and airspace opacities consistent with pulmonary sarcoidosis. b) Bronchoscopic view of the right main and right upper lobe bronchus (arrow) showing diffuse mucosal erythema. c) HRCT thorax image taken 15 months after initial presentation showing thickened interlobular septa and patchy ground-glass attenuation. The subsegmental …
A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain
Authors: M. Doherty, C. Hawkey, M. Goulder, I. Gibb, N. Hill, S. Aspley, S. Reader
Journal: Annals of the Rheumatic Diseases (2011)

<h3>Objectives</h3> To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain. <h3>Methods</h3> A randomised, double-blind, four-arm, parallel-group, active controlled trial investigating short-term (day 10) and long-term (week 13) benefits and side-effects of four regimens, each taken three times a day: ibuprofen (400 mg); paracetamol (1000 mg); one fixed-dose combination tablet (ibuprofen 200 mg/paracetamol 500 mg); two fixed-dose combination tablets (ibuprofen 400 mg/paracetamol 1000 mg). <h3>Results</h3> There were 892 participants (mean age 60.6, range 40–84 years); 63% had radiographic knee osteoarthritis and 85% fulfilled American College of Rheumatology criteria for osteoarthritis. At day 10, two combination tablets were superior to paracetamol (p&lt;0.01) for pain relief (determined by mean change from baseline in WOMAC pain; n=786). At 13 weeks, significantly more participants taking one or two combination tablets rated their treatment as excellent/good compared with paracetamol (p=0.015, p=0.0002, respectively; n=615). The frequency of adverse events was comparable between groups. However, by 13 weeks, decreases in haemoglobin (≥1 g/dl) were observed in some participants in all groups. Twice as many participants taking two combination tablets had this decrease compared with those on monotherapy (p&lt;0.001; paracetamol, 20.3%; ibuprofen, 19.6%; one or two combination tablets, 24.1%, 38.4%, respectively). <h3>Conclusions</h3> Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis. However, in this population, paracetamol 3 g/day may cause similar degrees of blood loss as ibuprofen 1200 mg/day, and the combination of the two appears to be additive. <h3>Study no</h3> ISRCTN77199439
Cause-Specific Mortality in a Population With Diabetes
Authors: Nick A. Roper, Rudy W. Bilous, William F. Kelly, Nigel C. Unwin, Vincent M. Connolly
Journal: Diabetes Care (2002)

OBJECTIVE—To describe the mortality of a population with diabetes compared with the local nondiabetic population, using age-, sex-, and cause-specific death rates and relative and absolute differences in death rates. RESEARCH DESIGN AND METHODS—A population-based cohort of 4,842 people with diabetes living within South Tees, U.K., was identified and followed from 1 January 1994 to 31 December 1999. Causes of death were obtained from death certificates, and mortality rates were compared with the nondiabetic population of the same area for the same time period. RESULTS—There were 1,205 deaths (24.9%) in the study population during the 6 years of study. For type 2 diabetes, mortality from cardiovascular causes was significantly increased in both sexes and at all ages. Relative death rates for the age band 40–59 years were 5.47 (95% CI 4.18–7.15) for men and 5.60 (3.44–9.14) for women. The relative death rates declined with age for both sexes, but absolute excess mortality increased with age. There were no consistent differences in noncardiovascular death rates, other than for renal disease. Similar outcomes were found for type 1 diabetes, although these results were limited by a much smaller population size. People with diabetes and renal impairment had significantly higher mortality than people with diabetes alone, with a rate ratio of 7.27 for people with type 2 diabetes aged 40–59 years. CONCLUSIONS—In an area of the U.K. with high cardiovascular death rates, people with diabetes had significantly higher cardiovascular death rates than people without diabetes. Interventions targeted at cardiovascular risk factors should be used to try and reduce this excess premature mortality, which is especially high in those with renal impairment.
A Decade of Molecular Studies of Fragile X Syndrome
Authors: William T. O'Donnell, Stephen T. Warren
Journal: Annual Review of Neuroscience (2002)

▪ Abstract Fragile X syndrome is one of the most common forms of inherited mental retardation. In most cases the disease is caused by the methylation-induced transcriptional silencing of the fragile X mental retardation 1 (FMR1) gene that occurs as a result of the expansion of a CGG repeat in the gene's 5′UTR and leads to the loss of protein product fragile X mental retardation protein (FMRP). FMRP is an RNA binding protein that associates with translating polyribosomes as part of a large messenger ribonucleoprotein (mRNP) and modulates the translation of its RNA ligands. Pathological studies from the brains of patients and from Fmr1 knockout mice show abnormal dendritic spines implicating FMRP in synapse formation and function. Evidence from both in vitro and in vivo neuronal studies indicates that FMRP is located at the synapse and the loss of FMRP alters synaptic plasticity. As synaptic plasticity has been implicated in learning and memory, analysis of synapse abnormalities in patients and Fmr1 knockout mice should prove useful in studying the pathogenesis of fragile X syndrome and understanding learning and cognition in general. If an appreciable portion of the total variance (in IQ) is due to sex linked genes, it is of more importance that a boy should have a clever mother than a clever father. Hogben 1932 (quoted in Lehrke 1974 )
Inferior Temporal Cortex: Where Visual Perception Meets Memory
Authors: Y Miyashita
Journal: Annual Review of Neuroscience (1993)

The neural processes that lead to visual perception and memory, thus subserving the identification of objects, have been assigned to the multi­ synaptic occipito-temporo-limbic projection that interconnects the striate, prestriate, inferior temporal, and hippocampal cortices (Gross 1972; Maunsell & Newsome 1987; Mishkin et al 1983). Recent advances in our understanding of the organization of the extra striate cortex revealed a mosaic of more than 25 visual areas beyond the striate cortex (Felleman & Van Essen 1991; Van Essen 1985; Zeki & Shipp 1988). The physical properties of a visuaJ object (such as its size, color, texture, and shape) are analyzed in the multiple subdivisions of the prestriate-posterior temporal complex. The anterior part of inferior temporal cortex has been hypo­ thesized not only to synthesize the analyzed attributes into a unique con­ figuration, but also to work as the storehouse for central representations of the objects (Mishkin 1982; Weiskrantz & Saunders 1984). The supporting evidence for this hypothesis has mainly been given by neuropsychological approaches (Milner 1990; Squire & Zola-Morgan 1991; Weiskrantz 1990). Recently, neuronal correlates of the visual long-term memory were found: The temporal-lobe neurons could reflect learned associative relations among stimuli (Miyashita 1988; Sakai & Miyashita 1991). The findings on this associational mechanism, together with that on the feature selectivity
T helper phenotype and genetic susceptibility in experimental Lyme disease.
Authors: J E Matyniak, S L Reiner
Journal: The Journal of Experimental Medicine (1995)

Infection of inbred mice with Borrelia burgdorferi results in strain-specific variation in the severity of pathogen-induced arthritis: BALB/c mice develop only mild disease whereas C3H/HeJ mice develop severe arthritis. The immunologic basis for varying host susceptibility has yet to be defined. We modified experimental Lyme disease to facilitate measurement of antigen-specific cytokine production in resistant and susceptible mice. The analysis revealed highly polarized lymphokine patterns directly linked to differing disease outcomes. Among the inbred strains of mice challenged with B. burgdorferi, production of interleukin 4 (IL-4) correlated to resistance whereas production of interferon gamma (IFN-gamma) correlated to susceptibility. We also demonstrate that production of IL-4 or IFN-gamma regulates the severity of arthritis after infection. Neutralization of IL-4 in resistant BALB/c mice resulted in more severe arthritis whereas neutralization of IFN-gamma in susceptible C3H/HeJ mice attenuated the severity of disease. These results suggest a primary relationship between T helper cell phenotype and the genetic basis for susceptibility to experimental Lyme borreliosis.
Relationship of Personality Disorders to the Course of Major Depressive Disorder in a Nationally Representative Sample
Authors: Andrew E. Skodol, Carlos M. Grilo, Katherine M. Keyes, Timothy Geier, Bridget F. Grant, Deborah S. Hasin
Journal: American Journal of Psychiatry (2011)

Objective: The purpose of this study was to examine the effects of specific personality disorder comorbidity on the course of major depressive disorder in a nationally representative sample. Method: Data were drawn from 1,996 participants in a national survey. Participants who met criteria for major depressive disorder at baseline in face-to-face interviews (in 2001–2002) were reinterviewed 3 years later (in 2004–2005) to determine persistence and recurrence. Predictors included all DSM-IV personality disorders. Control variables included demographic characteristics, other axis I disorders, family and treatment histories, and previously established predictors of the course of major depressive disorder. Results: A total of 15.1% of participants had persistent major depressive disorder, and 7.3% of those who remitted had a recurrence. Univariate analyses indicated that avoidant, borderline, histrionic, paranoid, schizoid, and schizotypal personality disorders all elevated the risk for persistence. With axis I comorbidity controlled, all personality disorders except histrionic personality disorder remained significant. With all other personality disorders controlled, borderline and schizotypal disorders remained significant predictors. In final, multivariate analyses that controlled for age at onset of major depressive disorder, the number of previous episodes, duration of the current episode, family history, and treatment, borderline personality disorder remained a robust predictor of major depressive disorder persistence. Neither personality disorders nor other clinical variables predicted recurrence. Conclusions: In this nationally representative sample of adults with major depressive disorder, borderline personality disorder robustly predicted persistence, a finding that converges with recent clinical studies. Personality psychopathology, particularly borderline personality disorder, should be assessed in all patients with major depressive disorder, considered in prognosis, and addressed in treatment.
Management of Lupus Nephritis
Authors: Frédéric A Houssiau
Journal: Journal of the American Society of Nephrology (2004)

Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease characterized by the production of pathogenic immunoglobulins, such as antinuclear and antiphospholipid autoantibodies. The kidney is one of its major target organ, with up to 60% of adult SLE patients experiencing renal
Innate immunity and inflammation — New frontiers in comparative cardiovascular pathology
Authors: A LINDE, D MOSIER, F BLECHA, T MELGAREJO
Journal: Cardiovascular Research (2006)

Innate immunity and inflammation play key roles in a wide range of pathology – including heart disease and vasculopathies. Current thinking suggests "damage" rather than "foreignness" as the actual trigger of the immune system, which has caused a dramatic change in how we tend to view the etiopathology of most types of heart disease. The future potential of certain anti-inflammatory therapeutic strategies in addressing heart disease is intriguing. Still, the Janus face of immunity/inflammation cannot be over emphasized as adverse manipulation of these systems may prove ineffectual or worse, damaging. Knowledge on functional characteristics of individual immune mediators is undoubtedly a central theme, but in depth understanding of the multiple biological actions of these molecules, as well as their contextual function, is the corner stone in deciding on potential future targets for pharmacologic manipulation. Animal models of human heart disease are currently being investigated and clinical trials conducted to gain further knowledge in this essential area of cardiovascular research, but the scarcity of cardiovascular research focusing on signaling molecules and pathways of innate immunity is still evident. Genomic and proteomic research in heart disease is going through its formative years, and much is still unknown about the complex pathway dynamics utilized by the innate immune system. This review will provide an overview of the current literature focusing on innate immunity and the heart, and hopefully will spark an interest in further basic as well as clinical research. As more information on cardiovascular immunity becomes available, this will provide a better understanding and thus act as the foundation for potential development of new treatment strategies for treatment of cardiovascular disorders.