tbuckley/cabot-search huggingface dataset:
SP0167 Bone Marrow and Synovial Fluid Stem Cells: In Vivo as Drivers of Spontaneous Tissue Repair
Authors: E. Jones
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Bone marrow and synovial fluid stem cells in vivo as drivers of spontaneous tissue repair Regenerative Medicine approaches have entered multiple fields of Medicine including Orthopedics, Neurodegenerative Disease, Liver disease and others. Various combinations of scaffolds, growth factors and stem cells have been used to restore the function of failing or missing tissues. For a rheumatologist, osteoarhtiris (OA), a disease that is lacking a cure and representing a significant burden to global economy, is currently seen as a primary target for regenerative approaches. To repair damaged joints in OA is not simply be able to fill-in defects in cartilage; as OA is a disease of the whole joint, a multi-faceted approach, involving better understanding of pain, joint biomechanics, inflammation, bone, cartilage and ligament homeostasis needs to be undertaken. As an important part of Regenerative Medicine triangle, stem cells are key cellular drivers of neotissue formation. Amongst a plethora of numerous stem cell types and lines potentially available to a rheumatologist in the future, the most abundant type amenable to easy harvesting and minimal manipulation are mesenchymal stem cells (MSCs). This presentation will outline recent findings pertaining to characterization of MSCs in human bone marrow (BM) and joint synovial fluid (SF), focusing on their native phenotypes in vivo and potential roles in spontaneous tissue repair. These two types of MSCs are also the most likely candidate ‘drivers’ of neocartlage formation following microfracture, a common treatment of focal cartilage defects. A better knowledge of joint MSC trafficking in health and post-injury is likely to lead to future improvements in cartilage maturation and long-term survival following this procedure, thus lowering the burden of post-traumatic OA. For large cartilage defects, significant academic and industrial investment remains focused on MSCs or chondrocytes expanded in vitro, however key recent observations on the presence of MSC in cartilage superficial layer and the SF suggest that the use of exogenously added, culture-expanded cells may not be necessary. This talk highlights innovative ideas and animal studies, in which minimal MSC manipulation in vivo has produced good restoration of joint morphology and function. For non-traumatic OA, the understanding of MSC responses to altered biomechanics and inflammation, as well as their routes of migration and homing to damaged tissues, could be the key to the development of novel, faster, minimally-invasive and cost-effective therapies of the future. <h3>Disclosure of Interest</h3> None Declared
The Urine and Clinical Chemistry of the Gastric Contents, the Common Poisons and Milk.
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0822 Adherence to Bisphosphonates Treatment of Osteoporosis
Authors: S. Stoica, G. Zugravu
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Osteoporosis is a serious public health concern and bisphosphonates (BPS) are the most common medications used in its treatment, whose main objective is to reduce the risk of fractures. <h3>Objectives</h3> The aim of this study was to explore the experiences and perceptions of postmenopausal women regarding strategies to improve adherence to osteoporosis therapy. <h3>Methods</h3> A total of 87 postmenopausal women between 45 and 70 years old with osteoporosis, currently taking BSP (30 with alendronate 70 mg/week, 28 with risedronate 35 mg/week and 29 with ibandronate 150 mg/month). All patients were interviewed and examined for the gathering of information on perceptions of their osteoporosis medications, their reasons for adherence and non-adherence to therapy, and the effectiveness of strategies they had tried to improve adherence at baseline, month 6 and month 12. Duration of therapy was measured by the count of days of therapy without of interruption of drug purchases greater than 2 weeks. Treatment compliance was evaluated with the Morisky Medication-taking Adherence Scale. <h3>Results</h3> One year after initiating treatment for osteoporosis, 79.6% of patients with monthly bisphosphonates and 67.0% of patients with weekly bisphosphonates were not continuing to fill prescriptions. Six variables were associated with compliance: treatment administration frequency, perceptions of long-term treatment acceptability, perceptions of health consequences of osteoporosis, perceptions of knowledge about osteoporosis, exercise and mental quality of life. In multivariate analyses, the risk of adherence failure was higher for weekly BPS versus monthly BPS therapy (hazard ratio [HR]=2.7, p&lt;0.01). <h3>Conclusions</h3> Compliance to anti-osteoporosis treatments is poor. The monthly dosage is associated with greater adherence compared to weekly dosage. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5944
Abstract 4210: Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissue
Authors: Gordon Fehringer, Geoffrey Liu, Melania Pintilie, Jenna Sykes, Ni Liu, Dangxiao Cheng, Zhuo Chen, Lesley Seymour, Sandy D. Der, Frances A. Shepherd, Ming-Sound Tsao, Rayjean J. Hung
Journal: Cancer Research (2012)

Abstract Lung cancer is one of the most commonly diagnosed cancers worldwide, with 1.6 million new cases reported each year and ranks first in annual global cancer deaths. Genome-wide association studies have identified two independent lung cancer susceptibility loci at chromosome 15q25 and one locus at 5p15. We examined the association of genetic variants in these lung cancer susceptibility regions with gene expression in lung tumor tissue in an effort to elucidate carcinogenic mechanisms by which these variants influence lung cancer risk. We used data from two independent studies: the JBR.10 clinical trial (131 NSCLC patients) and a patient sample from the University Health Network (UHN) in Toronto (181 NSCLC patients). We genotyped seven 15q25 and five 5p15 variants and examined their association with the expression profiles of genes in the corresponding regions measured by Affymetrix HG-U133A. The minor allele (C) of a variant representing one of the two loci at 15q25 (rs2036534) was associated with increased expression of the IREB2 (iron-responsive element binding protein 2) gene in both studies (JBR.10 P=0.042; UHN P=0.002). An FDRα0.05 in the UHN sample increased our confidence in this association. The association appears to be more prominent among patients with lung adenocarcinoma. We did not detect an association between the genotype and expression profile for the other 15q25 locus (represented by rs16969968 and rs1051730). Previous studies suggest that 15q25 variants are associated with risk through an effect on smoking behaviour, indicating risk is modulated through activity of nicotinic acetylcholine receptor genes present in this region. Our results indicate there is a second mechanism through which variants at 15q25 influence risk, operating through modulation of IREB2 gene expression. This finding may have implications for future research on lung cancer chemoprevention strategies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4210. doi:1538-7445.AM2012-4210
Quality-of-life results of an EORTC phase III randomized trial of adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases of solid tumors.
Authors: R. Soffietti, R. P. Mueller, M. U. Abacioglu, S. Villa, F. Fauchon, B. Baumert, L. Fariselli, G. Tridello, M. Kocher, A. Bottomley
Journal: Journal of Clinical Oncology (2010)

9036 Background: This study aimed to evaluate the effects of adjuvant whole brain radiotherapy (WBR) compared to no further radiotherapy after local treatment of a limited number of brain metastases in patients with stable solid tumor. We present the Health Related Quality of Life (HRQOL) results. Methods: HRQOL (EORTC QOL-C30 and BN-20) was a secondary endpoint in the trial. Out of 359, 317 patients (88.3% compliance) had baseline HRQOL assessments. Compliance was a challenge in this population: at month 6 some 51% of patients completed a HRQOL measure and at year one 45.1%. Therefore the analysis focuses on only the first year post baseline. The primary HRQOL endpoint was global QoL; secondary HRQOL endpoints were Cognitive, Physical, Emotional, Role Functioning and Fatigue. Sensitivity analyses were planned and undertaken for all scales. Statistical significance required p≤0.05 and clinical relevance ≥10 pt difference. Results: Over the year studied, there were no significant differences in the primary endpoint, global HRQOL (p<0.12). Patients who underwent WBR had a lower physical functioning score (p = 0.0325) and a deteriorated cognitive function (p = 0.006). However, the difference in physical function was clinically relevant only at week 8 and that in cognitive function only at year one. No differences between the treatments were found for role (p>0.1) or emotional functioning (p>0.1) or fatigue (p = 0.077). Exploratory analysis of several other HRQOL scales suggested worse scores for the WBR group, but these differences were not clinically relevant (<10 pt) and were not sustained in time for most other scales. Explorations also suggested that the detriment was generally greater in patients who had WBRT after radio surgery than after surgical removal of the brain metastases. Conclusions: In summary, patients who underwent WBR suffered from worse HRQOL levels, but very few differences were observed or reached the level of clinical or statistical significance. No significant financial relationships to disclose.
In Prone Ventilation, One Good Turn Deserves Another
Authors: Guy W. Soo Hoo
Journal: New England Journal of Medicine (2013)

The management of the acute respiratory distress syndrome (ARDS) remains daunting as we approach a half century since its description.1 Both direct and indirect insults produce acute lung injury, diffuse alveolar damage, and increased vascular permeability, with more severe involvement classified as ARDS.2 Although this suggests homogeneous injury, computed tomography clearly shows heterogeneous disease.3 Treatment with positive end-expiratory pressure (PEEP) and prone positioning improves oxygenation by increasing functional lung. Both increase functional residual capacity and decrease atelectasis, with improved ventilation–perfusion relationships with prone ventilation.4 Both interventions were in use within a decade after the description of ARDS. When patients are . . .
Association between <i>Chlamydia psittaci</i> infection and extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT)-lymphomas
Authors: A. Aigelsreiter, E. Stelzl, A. Deutsch, C. Beham-Schmid, A. Beham, G. Lanzer, W. Linkesch, H. Kessler, P. Neumeister
Journal: Journal of Clinical Oncology (2006)

7568 Background: MALT-lymphomas are often associated with infectious organisms. Microbial species associated with MALT lymphomas are: Helicobacter pylori (H.pylori), Campylobacter jejuni, Borrelia burgdorferi, and Hepatitis C Virus. Recent studies showed evidence of Chlamydia psittaci (C. psittaci) infection in 80% of ocular adnexal lymphoma and tumor regression following eradication therapy. We studied the presence of C. trachomatis, C. pneumoniae, and C. psittaci DNAs in MALT lymphomas of various sites and in non-malignant controls. Methods: MALT lymphomas from the following sites were selected for analysis: salivary gland (n=13), thyroid gland (n=4), skin (n=2), ocular adnexa (n=2), stomach (n=6), intestinum (n=4). Samples of Sjoegren syndrome (n=10) and samples of H. pylori positive gastritis (n=7) were included as non-malignant controls. Macrodissected tissue containing &gt;80% lymphoma cells from paraffin embedded tissue was processed for DNA isolation. For the presence of C. psittaci and C. pneumoniae DNA real time PCR assays were used. For C. trachomatis a commercially available PCR assay (Roche Molecular Diagnostics) was employed. All samples were tested twice. A sample was regarded as positive if at least one positive result was obtained. Results: C. psittaci was found at variable frequencies in MALT lymphomas of different sites: 4/13 (31%) salivary gland, 2/4 (50%) thyroid gland, 2/2 (100%) skin, 2/2 (100%) ocular adnexa, 1/6 (17%) gastric, and 0/4 intestinal MALT lymphomas. Among the non-malignant specimens, C. psittaci DNA was detected in 4/10 (40%) samples of Sjoegren syndrome and in 0/7 samples of H. pylori positive gastritis. All nongastric MALT lymphomas tested were negative for C. trachomatis and C. pneumoniae. Conclusion: Our data reveal a clear association of C. psittaci infection with extragastric MALT lymphoma. However, no evidence could be established for C. trachomatis and C. pneumoniae infection. Moreover, the high prevalence of Sjoegren syndromes - the most frequent precursor lesion for MALT lymphomas of salivary gland and ocular adnexa - may suggest an involvement of C. psittaci induced antigenic driven lymphomagenesis in a significant proportion of extragastric MALT lymphomas. No significant financial relationships to disclose.
Abstract 4166: Targeted expression of the <i>Pleomorphic adenoma gene 1</i> in the pancreas of mice leads to islet hyperplasia
Authors: Jeroen Declercq, Anujith Kumar, Janna Van Diepen, Irene Vroegrijk, Conny Gysemans, Caterina Di Pietro, Peter Voshol, Chantal Mathieu, Nadine Ectors, Wim Van de Ven, Catherine Vefaillie
Journal: Cancer Research (2010)

Abstract Pleomorphic adenoma gene 1 (PLAG1) encodes a transcription factor that is involved in several human neoplasias such as in pleomorphic adenomas of the salivary glands, lipoblastoma, hepatoblastoma and AML. The oncogenic capacity of PLAG1 has been further demonstrated in vivo in PLAG1 transgenic mice, in which the activation of the PLAG1 expression is Cre-mediated. Targeted expression of PLAG1 in the salivary gland or in the mammary gland leads to pleomorphic adenomas of the salivary glands and adenomyoepitheliomatous lesions of the mammary glands, respectively. Here, we investigated the impact of targeted PLAG1 expression in the pancreas. Pdx1-Cre-mediated targeted expression of PLAG1 in the whole pancreas, leads to islet hyperplasia. Although there was initially a balanced increase in the insulin, somatostatin and glucagon content of the pancreas, in older P1-Pdx1Cre mice the production of insulin and somatostatin far exceeded that of glucagon (82%, 275% and 9% respectively in 1 year old P1-Pdx1Cre mice as compared to littermate Pdx1-Cre mice). This was associated with hyperinsulinemia and an increased ability to dispose glucose in P1-Pdx1Cre mice, and progressive development of severe hypoglycaemia. Only 1/10 one year old mice developed a pancreatic tumor. We also investigated the consequence of overexpression of PLAG1 only in β-cells by using RIP-Cre mice. Similar to P1-Pdx1Cre mice, P1-RIPCre mice displayed islet hyperplasia, hyperinsulinemia and an increased ability to dispose glucose. Nevertheless, in contrast to P1-Pdx1Cre mice, P1-RIPCre mice stay normoglycemic and compensate for the hyperinsulinemia by the development of hepatic insulin resistance. In conclusion our data demonstrates that targeted expression of PLAG1 in the pancreas leads to islet hyperplasia rather than to pancreatic tumor formation. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4166.
Case 1-2010
Authors: Graham T. McMahon, Michael A. Blake, Chin-Lee Wu
Journal: New England Journal of Medicine (2010)

A 75-year-old man was admitted to this hospital because of the recent onset of hypertension, hyperglycemia, and edema. He had a history of prostate cancer, hemochromatosis, adrenal and thyroid nodules, and colonic polyps. The white-cell count was 17,400 per cubic millimeter with 87% neutrophils; the serum level of potassium was 2.6 mmol per liter and chloride 97 mmol per liter. Imaging studies showed pulmonary and hepatic nodules that had not been present on earlier studies. A diagnostic procedure was performed.
FRI0034 Taurine chloramine inhibition of cytokine secretion by rheumatoid adipose tissue and synovial membrane explants
Authors: E. Kontny, M. Plebanczyk, P. Maldyk, W. Maslinski, J. Marcinkiewicz
Journal: Annals of the Rheumatic Diseases (2013)

Posthypoxic myoclonus (PHM) is a syndrome of action and intention myoclonus that occurs in some patients who survive a cardiac arrest. Using PET and statistical parametric mapping, the authors observed a significant bilateral increase in glucose metabolism in the ventrolateral thalamus and pontine tegmentum in patients relative to controls. Interventions such as deep brain stimulation that interrupt networks that involve these structures may be useful in patients with severe PHM.
Case 24-1995
Authors: D.S. Lazarus, E.J. Mark
Journal: New England Journal of Medicine (1995)

Presentation of CaseA 46-year-old woman was admitted to the hospital for consideration of lung transplantation because of severe pulmonary hypertension.The patient had been well and working as a secretary until 16 months earlier, when proximal-muscle weakness developed, accompanied by myalgia, Raynaud's phenomenon, scaling plaques over the distal interphalangeal joints, and a maculopapular rash over the face, neck, and anterior chest that spared the eyelids and nasolabial folds; she began to have dyspnea. Evaluation elsewhere showed that the creatine kinase level was approximately 3000 U per liter. Electromyographic studies revealed evidence of muscle disease. Microscopical examination of a quadriceps . . .
THE EFFECT OF HIGH (200μG/KG/MIN) VERSUS STANDARD (140μG/KG/MIN) ADENOSINE DOSE IN PATIENTS WITH PD/PA VARIATION DURING STANDARD FFR ASSESSMENT
Authors: Dimitrios Alexopoulos, Periklis Davlouros, Grigorios Tsigkas, Nikolaos Koutsogiannis, Athanasios Moulias, Stelios Armilagos, Paraskevi Salata, Marianna Leopoulou, George Hahalis, Ioanna Xanthopoulou
Journal: Journal of the American College of Cardiology (2016)
FRI0112 Ultra Sonographic Evaluation of the Anterior Chest Wall in Spondyloarthritis. A Prospective Study
Authors: F. Verhoeven, X. Guillot, M. Godfrin-Valnet, C. Prati, D. Wendling
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Anterior chest wall (ACW) involvement is a characteristic feature of spondyloarthritis (SpA), even in early stages (1), but its paraclinic exploration is not standardized. <h3>Objectives</h3> The aim of this study was to evaluate prevalence and type of ultrasonic (US) ACW involvement in SpA, and to look for factors associated to this involvement. <h3>Methods</h3> This prospective monocentric study included consecutive SpA (ASAS criteria) patients and a control group (healthy subjects, discal sciatica). Clinical (pain, swelling) and US evaluation (synovitis, joint effusion, erosion, joint space narrowing, ankylosis, power Doppler activity) were performed on manubrio sternal and sterno clavicular joints. The main characteristics of SpA were recorded (disease duration, biologic features, BASDAI, ASDAS, radiographic and extra articular involvement). Patients were compared to controls (C). <h3>Results</h3> 131 SpA and 49 control patients (same age and sex ratio) were included. Clinical and US ACW involvement was found respectively in 36 and 39% of SpA and 10 and 15% of controls (p&lt;0.01). US findings were: synovitis (9 SpA vs 2 C), joint space narrowing (12 vs 0), erosions (34 vs 0), manubrio sternal ankylosis (24 vs 3), power Doppler activity (12 vs 2). US involvement in SpA is associated to smoking (p&lt;0.05), history of ACW pain (p&lt;0.05), to radiographic changes of sacro iliac joint (p=0.05), to age (45 vs 41 y, p=0.004), disease duration (14.9 vs 11.1 y, p=0.04) and presence of inflammatory bowel disease (p=0.03). US involvement is not associated to HLA-B27, enthesitis, psoriasis or uveitis, whereas clinical ACW involvement is associated with higher BASDAI (47 vs 32; p=0.0009) and ASADAS (2.9 vs 2.2; p=0.006). There is only a weak correlation between clinical and US involvement of ACW in these patients and controls. <h3>Conclusions</h3> US involvement of ACW is frequent in SpA, associated to disease duration, smoking and bowel involvement. <h3>References</h3> Wendling D, et al. J Rheumatol 2013;40:1148-52 <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1583
1355 IMIPRAMINE BLOCKS ETHANOL-INDUCED ASMASE ACTIVATION, CERAMIDE GENERATION, AND PP2A ACTIVATION, AND AMELIORATES HEPATIC STEATOSIS IN ETHANOL-FED MICE
Authors: S. Liangpunsakul, Y. Rahmani, R. Ross, Z. Zhao, Y. Xu, D. Crabb
Journal: Journal of Hepatology (2012)
Hypopharyngeal hirudiniasis presenting as hematemesis
Authors: Haluk Kani, Yucel Aydin, Nezih Yalcin, Mustafa Kaymakci, Hakan Akin
Journal: Endoscopy (2014)

Leeches belong to the Annelida division, Clitellata class, Hirudinea subclass. Common species of leeches that infest humans are Dinobdella ferox, Hirudinea granulosa, and Hirundinea viridis [1].