tbuckley/cabot-search huggingface dataset:
Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses
Authors: Darren Ruane, Alejo Chorny, Haekyung Lee, Jeremiah Faith, Gaurav Pandey, Meimei Shan, Noa Simchoni, Adeeb Rahman, Aakash Garg, Erica G. Weinstein, Michael Oropallo, Michelle Gaylord, Ryan Ungaro, Charlotte Cunningham-Rundles, Konstantina Alexandropoulos, Daniel Mucida, Miriam Merad, Andrea Cerutti, Saurabh Mehandru
Journal: The Journal of Experimental Medicine (2015)

Protective immunoglobulin A (IgA) responses to oral antigens are usually orchestrated by gut dendritic cells (DCs). Here, we show that lung CD103+ and CD24+CD11b+ DCs induced IgA class-switch recombination (CSR) by activating B cells through T cell–dependent or –independent pathways. Compared with lung DCs (LDC), lung CD64+ macrophages had decreased expression of B cell activation genes and induced significantly less IgA production. Microbial stimuli, acting through Toll-like receptors, induced transforming growth factor-β (TGF-β) production by LDCs and exerted a profound influence on LDC-mediated IgA CSR. After intranasal immunization with inactive cholera toxin (CT), LDCs stimulated retinoic acid–dependent up-regulation of α4β7 and CCR9 gut-homing receptors on local IgA-expressing B cells. Migration of these B cells to the gut resulted in IgA-mediated protection against an oral challenge with active CT. However, in germ-free mice, the levels of LDC-induced, CT–specific IgA in the gut are significantly reduced. Herein, we demonstrate an unexpected role of the microbiota in modulating the protective efficacy of intranasal vaccination through their effect on the IgA class-switching function of LDCs.
O031 : TG1050, a novel immunotherapeutic to treat chronic hepatitis B, can control HBsAg and provoke HBsAg seroconversion in HBV-persistent mouse models
Authors: K. Lélu, A. Evlachev, R. Kratzer, S. Dion, M. Mancini-Bourgine, O. Godon, D. Schmitt, C. Dubois, J.-F. Mériter, Y. Schlesinger, J.-B. Marchand, M. Geist, R. Brandely, A. Findeli, T. Menguy, N. Silvestre, M.-L. Michel, G. Inchauspe, P. Martin
Journal: Journal of Hepatology (2015)
Abstract 15695: Hematopoietic Deficiency of miR-223 Attenuates Thrombosis in Response to Photochemical Injury in Mice
Authors: Hui Wang, Wei Luo, Jintao Wang, Chiao Guo, Nayiri Kaissarian, Daniel T Eitzman
Journal: Circulation (2014)

Background:  MicroRNA (miR)-223 is highly expressed in platelets (PLT) and may serve as a biomarker of PLT activation. Some studies have shown that plasma levels of miR-223 are reduced following inhibition of PLT function, while others have shown a correlation between low plasma miR-223 levels and high on-treatment PLT reactivity. The present study is to investigate the role of miR-223 on arterial thrombosis following endothelial injury.   Methods and Results:  A model of rose bengal-induced photochemical injury was performed on carotid arteries of male C57BL/6 (C57B6), B6.SJL-Ptprc a  Pepc b /BoyJ (B6.SJL), and miR-223 deficient mice on C57B6-B6.SJL genetic background. Following carotid injury, miR-223 deficient mice showed significantly prolonged times to occlusive thrombosis compared to C57BL/6 and B6.SJL mice (90.0±5.4 vs 44.7±5.7 and 40.8±5.0 mins. n=6 per group, p 3 /[[Unsupported Character - Symbol Font ]]l) compared with C57B6 and B6.SJL mice (901.8±67.1 x 10 3 /[[Unsupported Character - Symbol Font ]]l and 896.8±30.3 x 10 3 /[[Unsupported Character - Symbol Font ]]l) (n=5 per group, P 3 /[[Unsupported Character - Symbol Font ]]l vs 925.4±21.1 x 10 3 /[[Unsupported Character - Symbol Font ]]l, n=5 per group, p   Conclusion:  Hematopoietic miR-223 is a potent regulator of arterial thrombosis following endothelial injury. This study indicates that miR-223 is a potential therapeutic target for prevention of arterial thrombosis.
Survival from first recurrence: relative importance of prognostic factors in 1,015 breast cancer patients.
Authors: G M Clark, G W Sledge, C K Osborne, W L McGuire
Journal: Journal of Clinical Oncology (1987)

Univariate and multivariate analyses of potential prognostic factors for 1,015 women with recurrent breast cancer confirmed that the site of initial recurrence is an important determinant for predicting survival from the time of initial recurrence. However, both estrogen receptor (ER) status and axillary lymph node status at diagnosis, as well as the length of the disease-free interval, provide additional independent information for predicting patient survival after disease recurrence. Involved axillary lymph nodes at the time of initial diagnosis and/or lack of ERs may indicate a highly malignant tumor or a weak host defense, either of which might be related to short survival after relapse. Patients with ER-negative tumors recurred more often in visceral and soft-tissue sites, while patients with ER-positive tumors were more likely to recur in bony sites. However, for each metastatic site, receptor-positive patients had longer survival
The Sustainable Development Goals
Authors: Lawrence O. Gostin, Eric A. Friedman
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;emph type="ital"&gt;Collage Arranged According to the Laws of Chance&lt;/emph&gt;
Authors: Charlene Breedlove
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Selective responses of human gingival fibroblasts and bacteria on carbon fiber reinforced polyetheretherketone with multilevel nanostructured TiO2
Authors: Xiao Wang, Tao Lu, Jin Wen, Lianyi Xu, Deliang Zeng, Qianju Wu, Lingyan Cao, Shuxian Lin, Xuanyong Liu, Xinquan Jiang
Journal: Biomaterials (2016)
COPDCoRi, an algorithm for predicting the risk of coronaropathy in COPD patients
Authors: Paola Rogliani, Luigino Calzetta, Francesco Romeo, Saverio Muscoli, Maria Gabriella Matera, Mario Cazzola
Journal: European Respiratory Journal (2014)

Background 

COPD is often associated with cardiovascular disease (Cazzola, M. et al. Respir Med 2012;106:249-256).

Aim 

To identify an algorithm for predicting the risk of coronary heart disease (CHD) in COPD patients.

Methods 

We analyzed data of patients afferent to the Cardiology ward and the Respiratory Diseases outpatient clinic of Tor Vergata University (2009-2011, 1596 records). The study population was clustered as training population (COPD patients undergoing coronary arteriography), control population (non-COPD patients undergoing coronary arteriography), test population (COPD patients whose records reported information on the coronary status). The predicting model was built via causal relationship between variables, stepwise binary logistic regression (Odds Ratio, OR) and Hosmer–Lemeshow analysis. The algorithm was validated via split-sample validation method and receiver operating characteristics (ROC) curve analysis. The diagnostic accuracy was assessed.

Results 

In training population the variables gender (men/women OR: 1.7, 95%CI: 1.2-2.5, P<0.05), dyslipidemia (OR: 1.8, 95%CI: 1.2-2.5, P<0.01) and smoking habit (OR: 1.5, 95%CI: 1.2-1.9, P<0.001) were significantly associated with CHD in COPD patients, whereas in control population also age and diabetes were correlated. The stepwise binary logistic regression permitted to build a well fitting predictive model for training population but not for control population. The predictive algorithm showed a diagnostic accuracy of 81.5% (95%CI: 77.8-84.7) and an AUC of 0.71 (95%CI: 0.68-0.74) for the validation set.

Conclusions 

COPDCoRi is effective in predicting the risk of CHD in COPD patients via a rapid, inexpensive and non-invasive approach.
Effects of colchicine on risk of cardiovascular events and mortality among patients with gout: a cohort study using electronic medical records linked with Medicare claims
Authors: Daniel H Solomon, Chih-Chin Liu, I-Hsin Kuo, Agnes Zak, Seoyoung C Kim
Journal: Annals of the Rheumatic Diseases (2015)

Background Colchicine may have beneficial effects on cardiovascular (CV) disease, but there are sparse data on its CV effect among patients with gout. We examined the potential association between colchicine and CV risk and all-cause mortality in gout. Methods The analyses used data from an electronic medical record (EMR) database linked with Medicare claims (2006–2011). To be eligible for the study cohort, subjects must have had a diagnosis of gout in the EMR and Medicare claims. New users of colchicine were identified and followed up from the first colchicine dispensing date. Non-users had no evidence of colchicine prescriptions during the study period and were matched to users on the start of follow-up, age and gender. Both groups were followed for the primary outcome, a composite of myocardial infarction, stroke or transient ischaemic attack. We calculated HRs in Cox regression, adjusting for potential confounders. Results We matched 501 users with an equal number of non-users with a median follow-up of 16.5 months. During follow-up, 28 primary CV events were observed among users and 82 among non-users. Incidence rates per 1000 person-years were 35.6 for users and 81.8 for non-users. After full adjustment, colchicine use was associated with a 49% lower risk (HR 0.51, 95% CI 0.30 to 0.88) in the primary CV outcome as well as a 73% reduction in all-cause mortality (HR 0.55, 95% CI 0.35 to 0.85, p=0.007). Conclusions Colchicine use was associated with a reduced risk of a CV event among patients with gout.
The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system
Authors: Panagiotis S Kabouridis, Reena Lasrado, Sarah McCallum, Song Hui Chng, Hugo J Snippert, Hans Clevers, Sven Pettersson, Vassilis Pachnis
Journal: Gut Microbes (2015)

The enteric nervous system (ENS) coordinates the major functions of the gastrointestinal tract. Its development takes place within a constantly changing environment which, after birth, culminates in the establishment of a complex gut microbiota. How such changes affect ENS development and its subsequent function throughout life is an emerging field of study that holds great interest but which is inadequately explored thus far. In this addendum, we discuss our recent findings showing that a component of the ENS, the enteric glial cell network that resides in the gut lamina propria, develops after birth and parallels the evolution of the gut microbiota. Importantly, this network was found to be malleable throughout life by incorporating new cells that arrive from the area of the gut wall in a process of directional movement which was controlled by the lumen gut microbiota. Finally, we postulate on the roles of the intestinal epithelium and the immune system as potential intermediaries between gut microbiota and ENS responses.
Oral contraceptives and reproductive mortality [letter]
Authors: Sachs Bp
Journal: New England Journal of Medicine (1984)

The objective of our article was to show that the risk of oral contraception is far smaller that the risk of pregnancy and especially of an unwanted one.  In an era of low-dose oral contraception there have been no studies examining the associated mortality.  We were able to calculate a mortality rate because a survey of contraceptive prevalence had been conducted in the state.  In addition the prevalence of smoking in the community was known.  The issue of causality in mortality studies is a difficult one.  However we did not find it so difficult to associate a cardiovascular death with oral contraception in a premenopausal woman who is hypertensive and smokes.  (full text)
In lasting tribute: Professor Dr Işil Berat Barlan (1958-2015)
Authors: Cezmi Akdis, Mübeccel Akdis, Talal A. Chatila, Günnur Deniz, Raif S. Geha, Michael J. Lenardo, Hans C. Oettgen
Journal: Journal of Allergy and Clinical Immunology (2015)
Outcomes of Respiratory Syncytial Virus Immunoprophylaxis in Infants Using an Abbreviated Dosing Regimen of Palivizumab
Authors: Pascal M. Lavoie, Alfonso Solimano, Richard Taylor, Eddie Kwan, Jennifer Claydon, Stuart E. Turvey, Nico Marr
Journal: JAMA Pediatrics (2015)

intelligence.If β break indicates a statistically significant upward shift in a carefully calibrated estimation model, which also includes all plausible and available environmental controls, there is strong evidence that the resulting partial regression coefficient of duration of breastfeeding is still not reflecting pure nutritional effects.The pattern shown in this study also helps explain why studies comparing children who have ever been breastfed and those who have never been breastfed find no difference in intelligence.
The use of tacrine for tardive dyskinesia
Authors: N A Ingram, D B Newgreen
Journal: American Journal of Psychiatry (1983)

The authors administered 45-90 mg/day of tacrine to eight patients with tardive dyskinesia. After 2 weeks of treatment, there was a mean reduction in tardive dyskinesia scores of 43%. No improvement occurred when a placebo was used instead of tacrine.
Obesity and Breast Cancer Outcomes: How Much Evidence Is Needed to Change Practice?
Authors: Pamela J. Goodwin
Journal: Journal of Clinical Oncology (2015)

The reason for these discrepant findings is unclear. It is possible that the more aggressive breast cancer treatment given in clinical trials may negate any effect of obesity on breast cancer outcomes. It is also possible that the women enrolled in such studies are more metabolically healthy than those not enrolled in clinical trials (a pattern seen during recruitment in the Physicians’ Health Study 5 ), particularly in view of concerns related to cardiac health when anthracyclines or trastuzumab are studied. 6 The emerging recognition that benefits of aromatase inhibitors other than letrozole (v tamoxifen) are lower in obese (v normal-weight) women suggests that careful selection of hormonal therapy may yield optimal outcomes in obese women. Although the primary focus of research into lifestyle associations with breast cancer outcomes has been on obesity, there is also evidence that physical activity is associated with better breast cancer outcomes. 7 Most analyses have been retrospective and the study designs heterogeneous (eg, physical activity was measured prior to, immediately after, or years after breast cancer diagnosis). However, associations of higher levels of physical activity with lower risk of recurrence have been identified in most studies. Dietary fat intake may also affect breast cancer outcomes. The Women’s Intervention Nutrition Study 8 reported that randomization to a low-fat diet (associated with modest weight loss) significantly improved relapse-free survival in early-stage breast cancer(hazard ratio,0.76);inlong-termfollow-up,thesignificance of these associations was not maintained. In contrast, the Women’s Healthy Eating and Living randomized trial reported no association of a complex dietary intervention (that included fat reduction but did not lead to weight loss) with recurrence or survival in women with breast cancer. 9 These discrepant results may be due
Bloodstream infection caused by extensively drug-resistant Acinetobacter baumannii in cancer patients: high mortality associated with delayed treatment rather than with the degree of neutropenia
Authors: M.P. Freire, D. de Oliveira Garcia, C.P. Garcia, M.F. Campagnari Bueno, C.H. Camargo, A.S.G. Kono Magri, G.R. Francisco, R. Reghini, M.F. Vieira, K.Y. Ibrahim, F. Rossi, L. Hajjar, A.S. Levin, P.M. Hoff, L.C. Pierrotti, E. Abdala
Journal: Clinical Microbiology and Infection (2015)
What’s hot that the other lot got
Authors: Ben Soar
Journal: Thorax (2016)

Statins are known to have anti-inflammatory and immunomodulatory effects. Retrospective studies have suggested a benefit in community-acquired pneumonia. This prospective study ( Clin Infect Dis doi:10.1093/cid/ciw174) enrolled a total of 2016 patients, 483 (24%) were statin users, 1533 (76%) were not. The primary outcome was length of hospital stay (LOS) with mortality a secondary outcome. No statistical difference was found between LOS and mortality in the two groups, even when stratified for pneumonia severity. The authors conclude that there is no evidence of benefit for statin users.

This randomised clinical trial ( JAMA 2016;315:2178–89) included 315 patients with emphysema and severe air trapping, recruited from multiple centres in the USA and Europe. Patients were randomly assigned to continued usual care alone (157) versus usual care plus bilateral coil treatment (158). Coil treatment involved two treatments four months apart with 10–14 coils placed in a single lobe of each lung. Primary outcome was the difference in a 6 min walk test …
Risk factors for and outcomes of patients with POEMS syndrome who experience progression after first-line treatment
Authors: T V Kourelis, F K Buadi, M A Gertz, M Q Lacy, S K Kumar, P Kapoor, R S Go, J A Lust, S R Hayman, V Rajkumar, S R Zeldenrust, S J Russell, D Dingli, Y Lin, N Leung, Y L Hwa, W Gonsalves, R A Kyle, A Dispenzieri
Journal: Leukemia (2015)
Recombinant VP1 regulates migration of cancer cells and macrophages differentially via let-7a and MMP-9
Authors: Shu-Mei Liang, Chi-Ming Liang, Chiao-Chun Liao
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Recombinant capsid protein VP1 (rVP1) of foot-and-mouth disease virus is a protein exhibiting potent cytotoxicity to a variety of cancer cells. We have recently found that rVP1 is capable of decreasing cancer cell motility but increasing macrophages motility. The underlying
Modulation of Bcl-2 Protein by CD4 Cross-Linking: A Possible Mechanism for Lymphocyte Apoptosis in Human Immunodeficiency Virus Infection and for Rescue of Apoptosis by Interleukin-2
Authors: Futoshi Hashimoto, Naoki Oyaizu, Vaniambadi S. Kalyanaraman, Savita Pahwa
Journal: Blood (1997)
Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice
Authors: Satoko Arai, Kento Kitada, Tomoko Yamazaki, Ryosuke Takai, Xizhong Zhang, Yoji Tsugawa, Ryoichi Sugisawa, Ayaka Matsumoto, Mayumi Mori, Yasunori Yoshihara, Kent Doi, Natsumi Maehara, Shunsuke Kusunoki, Akiko Takahata, Eisei Noiri, Yusuke Suzuki, Naoki Yahagi, Akira Nishiyama, Lakshman Gunaratnam, Tomoko Takano, Toru Miyazaki
Journal: Nature Medicine (2016)
Medical Research Council prospective study of surveillance for stage I testicular teratoma. Medical Research Council Testicular Tumors Working Party.
Authors: G Read, S P Stenning, M H Cullen, M C Parkinson, A Horwich, S B Kaye, P A Cook
Journal: Journal of Clinical Oncology (1992)

PURPOSE A prospective study of surveillance after orchidectomy alone in patients with stage I nonseminomatous germ cell testicular tumor (NSGCT) was performed to determine the relapse-free rate and to identify the histologic criteria that predict for relapse. PATIENTS AND METHODS Three hundred ninety-six patients from 16 United Kingdom and one Norwegian centers were entered onto the study between January 1, 1984 and October 1, 1987 of whom 373 were eligible for analysis. In a previous retrospective study, we defined a prognostic index based on histologic criteria that identified a group of patients with a high risk of relapse. This index was based on the presence of venous and lymphatic invasion, undifferentiated cells, and the absence of yolk sac elements in the primary tumor. RESULTS The 2-year actuarial relapse-free rate after orchidectomy was 75% (95% confidence interval, 71% to 79%), and the rate at 5 years was 73%. Five patients died of tumor or treatment-related complications, which resulted in a 5-year survival of 98%. The relapse-free rate in patients with three or four risk factors was 54%. CONCLUSIONS This study confirms the safety of surveillance as a method of management and identifies a group of patients with a high risk of relapse. A prospective phase II study has been initiated to determine whether two courses of platinum-based adjuvant chemotherapy will prevent relapse in these high-risk patients.
A Comparison of Outcomes of Endoscopic Retrograde Cholangiopancreatography Versus Percutaneous Transhepatic Biliary Drainage in the Management of Obstructive Jaundice From Hepatobiliary Tuberculosis: The Philippine General Hospital Experience
Authors: M.E.J. Villamayor, L.A. Padua, N.S. Bacaltos, V.P. Bañez
Journal: Clinical Gastroenterology and Hepatology (2015)