Vancomycin-Associated Linear IgA Bullous Dermatosis
Authors: Hossein C. Nousari
Journal: Annals of Internal Medicine (1998)

Letters15 September 1998Vancomycin-Associated Linear IgA Bullous DermatosisHossein C. Nousari, MD, Constantino Costarangos, MD, and Grant J. Anhalt, MDHossein C. Nousari, MDJohns Hopkins Medical Institutions; Baltimore, MD 21205, Constantino Costarangos, MDJohns Hopkins Medical Institutions; Baltimore, MD 21205, and Grant J. Anhalt, MDJohns Hopkins Medical Institutions; Baltimore, MD 21205Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-6-199809150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Linear IgA bullous dermatosis (LABD) is an uncommon autoimmune subepidermal blistering disorder characterized by deposition of IgA autoantibodies in a lincar pattern along the epidermal basement membrane zone [1, 2]. Most cases of LABD are idiopathic, but an association with vancomycin has been recently described [3]. This association is not yet widely appreciated.A 65-year-old woman was admitted to the hospital with subarachnoid hemorrhage secondary to a ruptured aneurysm. On hospital day 6, her clinical course was complicated by Pseudomonas aeruginosa and Staphylococcus epidermidis sepsis, for which intravenous vancomycin, gentamicin, and ticarcillin-clavulanate were administered. Other medications included ...References1. Nousari HC, Anhalt GJ. Bullous skin diseases. Curr Opin Immunol. 1995; 7:844-52. Google Scholar2. Nousari HC, Anhalt GJ. Skin diseases. In: Rose NR, de Macario EC, Folds JD, Lane HC, Nakamura RM, eds. Manual of Clinical Laboratory Immunology. 5th ed. Washington, DC: American Society for Microbiology; 1997:997-1004. Google Scholar3. Kuechle MK, Stegemeir E, Maynard B, Gibson LE, Leiferman KM, Peters MS. Drug-induced linear IgA bullous dermatosis: report of six cases and review of the literature. J Am Acad Dermatol. 1994; 30:187-92. Google Scholar4. Whitworth JM, Thomas I, Peltz SA, Sullivan BC, Wolf AH, Cytryn AS. Vancomycin-induced linear IgA bullous dermatosis (LABD). J Am Acad Dermatol. 1996; 34:890-1. Google Scholar5. Bitman LM, Grossman ME. Bullous drug eruption treated with amputation. A challenging case of vancomycin-induced linear IgA disease. Arch Dermatol. 1996; 132:1289-90. Google Scholar Author, Article, and Disclosure InformationAffiliations: Johns Hopkins Medical Institutions; Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFixed drug eruptions, bullous drug eruptions, and lichenoid drug eruptionsLinear IgA Bullous Dermatosis Preceding the Diagnosis of Primary Sclerosing Cholangitis and Ulcerative Colitis: A Case ReportTopical imiquimod-induced linear IgA bullous dermatosisVancomycin‐induced linear IgA bullous dermatosis ( LABD )—an atypical presentationLinear IgA bullous dermatosisImmunoglobulin A DermatosesOld dog begging for new tricksImmune-mediated reactions to vancomycinVancomycinA case of vancomycin-associated linear IgA bullous dermatosis and IgA antibodies to the α3 subunit of laminin-332A critical reappraisal of the current data on drug-induced linear immunoglobulin A bullous dermatosis: A real and separate nosological entity?Bullous Dermatosis Associated With Vancomycin ExtravasationANTIBACTERIAL DRUGSAmoxicillin-clavulanic acid-induced linear immunoglobulin A bullous dermatosis: case report and review of the literatureAmoxicillin-associated linear IgA bullous dermatosisVancomycinDrug-Induced Linear IgA Bullous DermatosisVancomycin-induced linear IgA disease manifesting as bullous erythema multiformeBullous Skin Disease: An Unusual Allergic Reaction to VancomycinLinear Immunoglobulin a Bullous Dermatosis Induced by GemcitabineBurn-induced linear IgA dermatosisDrug-induced linear IgA bullous dermatosis after vancomycin discontinuance in a patient with renal insufficiencyMiscellaneous antibacterial drugsLinear IgA bullous dermatosisVancomycin-induced linear IgA bullous diseaseLife-Threatening Reaction to Vancomycin Given for Noninfectious FeverA Patient with a Refractory Cutaneous Bullous EruptionClinical, Demographic, and Immunohistologic Features of Vancomycin-Induced Linear IgA Bullous Disease of the Skin Report of 2 Cases and Review of the LiteratureVancomycin 15 September 1998Volume 129, Issue 6Page: 507-508KeywordsAutoantibodiesBasement membraneDirect immunofluorescenceDrugsLesionsSkin diseasesStaphylococcus epidermidisSubarachnoid hemorrhageSulfatesVancomycin Issue Published: 15 September 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...