tbuckley/cabot-search huggingface dataset:
Genomic patient information management system
Authors: D Dharmiah, M Narasinga Rao, None Ravikiran, N Sandeep, V DS Gopal, Allam Appa Rao, GR Sridhar
Journal: Genome biology (2010)

Components We developed a model retrieval “Genomic patient information management system” It caters to the requirements of clinicians and patients by acting as an interface which allows 1) Maintaining the patient records with diagnosis reports 2) Sending the next appointment dates to the patients through an SMS facility. 3) E-mail facility to provide interaction b/n patient and doctor. 4) Creating a Semantic network model for storing the genomic information 5) Indexing facility to check the database of genomic information 6) A Search Engine, to search for a key word in the genomic database 7) Offering provable protection from individual re identification based on clinical features 8) Allowing sensitive patterns of genomic codes to be automatically extracted 9) generating anonymization to ensure individual privacy 10) performing clinical case analysis tasks.
REQUIREMENT FOR α-<scp>L</scp>-FUCOSE ON THE MACROPHAGE MEMBRANE RECEPTOR FOR MIF
Authors: Heinz G. Remold
Journal: The Journal of Experimental Medicine (1973)

α-L-fucose abolishes the activity of guinea pig migration inhibitory factor (MIF) on the macrophages. Other sugars such as α-D-glucose, ß-D-galactose, α-L-rhamnose, methyl-α-D-mannoside, and N-acetyl-ß-D-glucosamine had no effect. Theabolition of MIF activity by α-L-fucose was reversible. When macrophages were incubated with α-L-fucosidase, a glycosidase which splits terminal α-L-fucose from oligosaccharides, the macrophages no longer responded to MIF. On the other hand, MIF incubated with α-L-fucosidase was still active. These experiments strongly suggest that α-L-fucose comprises an essential part of a macrophage membrane receptor for MIF.
Tumour necrosis factor inhibition causing psoriasis? A more plausible explanation exists
Authors: J D Carter
Journal: Annals of the Rheumatic Diseases (2006)

I read with interest the report by Kary et al ,1 who reported nine patients who developed psoriatic skin lesions after treatment with tumour necrosis factor (TNF)α antagonists. Their diagnosis was psoriasis palmo-plantaris pustulosa or psoriasis vulgaris, and they proposed that this was an adverse reaction to the TNFα antagonists. Interestingly, they specifically report that six of nine patients had psoriatic-like lesions on their palms and soles. In only one patient do they specifically state that the lesions did not involve the palms and soles.

This same paradoxical adverse reaction to treatment with TNFα antagonists was recently postulated by Sfikakis et al .2 They described five patients who developed apparent psoriasis after treatment with a TNF antagonist. …
Cardiac Arrhythmias After Dexamethasone
Authors: Gopal Rao
Journal: JAMA (1972)

To the Editor.—  I would like to make some comments on the article by Schmidt et al titled, Sudden Appearance of Cardiac Arrhythmias After Dexamethasone (221:1402, 1972).  They are implying that the multifocal, premature ventricular contractions were caused by dexamethasone. We used to see similar episodes of arrhythmia frequently in our early experience with open-heart surgery. After about 600 open-heart operations, we have reduced the incidence to a minimum by strictly observing certain changes that are common in open-heart surgery.  First of all, we know alkalosis of any cause predisposes to severe arrhythmias, particularly if induced by potent diuretics like furosemide (Lasix) and ethacrynic acid (Edecrin), which are used frequently.  Second, hypokalemia is a frequent predisposing cause of severe arrhythmias. I did a clinical research of 20 consecutive patients who underwent revascularization surgery of the myocardium, 17 of whom were on temporary cardiopulmonary bypass. We prime our bubble oxygenator with
Species-dependent effects of adenosine on heart rate and atrioventricular nodal conduction. Mechanism and physiological implications.
Authors: G Froldi, L Belardinelli
Journal: Circulation Research (1990)

This study 1) compares the negative chronotropic and dromotropic actions of adenosine in guinea pig, rat, and rabbit hearts; 2) investigates the mechanism(s) for the different responses; and 3) determines the physiological implications. Isolated perfused hearts were instrumented for measurement of atrial rate and atrioventricular (AV) nodal conduction time. Differences in metabolism of adenosine were determined in the absence and presence of dipyridamole (nucleoside uptake blocker) and erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA, adenosine deaminase inhibitor). Dipyridamole plus EHNA decreased adenosine's EC50 for the negative dromotropic effect by 14-fold in guinea pig heart and 1.6-fold in rat heart. This is consistent with the greater number of [3H]nitrobenzylthioinosine binding sites measured in membranes from guinea pig (1,231 +/- 68 fmol/mg protein) compared with rat (302 +/- 31 fmol/mg protein) and rabbit (260 +/- 28 fmol/mg protein) atria. The potency of adenosine to slow atrial rate and prolong AV nodal conduction time was greater in guinea pig than in rat or rabbit hearts. This rank order of potency correlated well with the number of binding sites for the specific adenosine receptor radioligand 125I-aminobenzyladenosine in guinea pig (102 +/- 13 fmol/mg protein), rat (11 +/- 0.5 fmol/mg protein), and rabbit (8 +/- 1 fmol/mg protein) atrial membranes. Hypoxia increased the rate of adenosine release by severalfold and caused slowing of heart rate and AV block. In spontaneously beating hearts, the main effect of hypoxia was a slowing of ventricular rate, which in the guinea pig heart was due to AV block and in the rat heart to atrial slowing. In atrial paced hearts, hypoxia caused a marked prolongation of AV nodal conduction time in guinea pig (39 +/- 4 msec) and rabbit (29 +/- 5 msec) hearts, but only small effect in rat hearts (10 +/- 2 msec). The differences in response to hypoxia could be accounted for by the species-dependent differences in the 1) amount of adenosine released and metabolized, 2) sensitivity of the hearts to adenosine, and 3) dependency of AV nodal conduction on atrial rate. The findings indicate that the results from physiological or pharmacological studies on adenosine in one species may not be applicable to others, and the ultimate effect of adenosine and hypoxia is to slow ventricular rate.
Preliminary communication: matrix metalloproteinases in Kaposi's sarcoma
Authors: U. Impola, M.A. Cuccuru, M.V. Masala, L. Jeskanen, F. Cottoni, U. Saarialho-Kere
Journal: British Journal of Dermatology (2003)

Journal Article Preliminary communication: matrix metalloproteinases in Kaposi's sarcoma Get access U. Impola, U. Impola Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar M.A. Cuccuru, M.A. Cuccuru Istituto di Dermatologia, Università degli Studi di Sassari, Sassari, Italy Search for other works by this author on: Oxford Academic Google Scholar M.V. Masala, M.V. Masala Istituto di Dermatologia, Università degli Studi di Sassari, Sassari, Italy Search for other works by this author on: Oxford Academic Google Scholar L. Jeskanen, L. Jeskanen Pathology, Helsinki University Central Hospital, Meilahdentie 2, 00250 Helsinki, Finland Search for other works by this author on: Oxford Academic Google Scholar F. Cottoni, F. Cottoni Istituto di Dermatologia, Università degli Studi di Sassari, Sassari, Italy Search for other works by this author on: Oxford Academic Google Scholar U. Saarialho‐Kere U. Saarialho‐Kere Departments of DermatologyClinical Research Centre, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden Ulpu Saarialho‐Kere, E‐mail: ulpu.saarialho‐kere@helsinki.fi Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 4, 1 October 2003, Pages 905–907, https://doi.org/10.1046/j.1365-2133.2003.05561.x Published: 01 October 2003
Erythropoietic Response of Dialyzed Patients to Testosterone Administration
Authors: JOHN R. RICHARDSON
Journal: Annals of Internal Medicine (1970)

Fifteen patients on a program of maintenance dialysis were given courses of testosterone enanthate therapy in weekly doses of 400 to 600 mg, intramuscularly, for 5 to 44 weeks. Thirteen patients exhibited a mean increment in hematocrit (5.6%), red cell volume (353 ml), and red cell volume per kilogram body weight (4.4 ml/kg). The mean rate of plasma iron clearance increased (-36.7 min). In several individuals marked improvement in anemia occurred. Two iron-deficient patients failed to exhibit an erythropoietic response to testosterone. A satisfactory response followed iron replacement. Androgenic hormones may be useful in the treatment of patients with advanced renal failure who are adequately dialyzed, well nourished, and not iron-deficient. This treatment, in conjunction with other measures aimed toward amelioration of anemia, has eliminated transfusion requirements in most of our patients.
Exceptionally high serum erythropoietin activity in an anephric patient with severe anemia
Authors: Jorge A. Ortega, Mohammed H. Malekzadeh, Peter P. Dukes, Andrew Ma, Alfred V. Pennisi, Richard N. Fine, Nomie A. Shore
Journal: American Journal of Hematology (1977)

Abstract An exceptionally high serum erythropoietin (EPO) activity was documented in an anephric patient with severe anemia who required transfusions every 4 weeks. The patient's serum EPO was comparable to normal human urinary EPO in the polycythemic mouse assay and was neutralized by an antiserum against EPO. The patient's serum inhibited EPO stimulated‐heme synthesis by normal human marrow cells in vitro. This finding suggests that an inhibitor played an important role in causing the anemia of this uremic patient.
Isolation and analysis of immune complexes from sera of patients with polymyalgia rheumatica and giant cell arteritis.
Authors: A J Smith, V Kyle, T E Cawston, B L Hazleman
Journal: Annals of the Rheumatic Diseases (1987)

Serum samples were obtained from patients with polymyalgia rheumatica (PMR: n = 10) or giant cell arteritis (GCA; n = 7), or both. Samples were taken either before treatment or within one week of starting prednisolone. Immune complexes (IC) were concentrated by polyethylene glycol (PEG) precipitation then purified with either IgG anti-C1q-Sepharose or IgG anti-C3c-Sepharose. Complex components were separated by sodium dodecyl sulphate (SDS) gradient polyacrylamide gel electrophoresis then transferred to nitrocellulose by Western blotting. Identification of proteins was carried out using specific antisera. All the IC contained IgM (mu chain), some contained IgA (alpha chain), and IgG (gamma chain). C1r, C1s, C1q, C3, C4, and C reactive protein (CRP), where tested, were found in most but not all IC. The occurrence of properdin, factor B, alpha 2 macroglobulin (alpha 2M), factor H (beta 1H), C1 esterase inhibitor, and C4 binding protein was also investigated. Immune complexes in PMR and GCA differed from those previously characterized in rheumatoid arthritis (RA)1 purified by anti-C1q-Sepharose which contained immunoglobulins and C1q only. No properdin or factor B were detected in RA IC purified with either anti-C1q-Sepharose or anti-C3c-Sepharose.
Menarchal Timing in Type 1 Diabetes Through the Last 4 Decades
Authors: Bahareh Schweiger, Georgeanna J. Klingensmith, Janet K. Snell-Bergeon
Journal: Diabetes Care (2010)

OBJECTIVE We sought to examine whether age at menarche has changed over the past 4 decades by comparing age at menarche by year of diagnosis with type 1 diabetes. RESEARCH DESIGN AND METHODS This work consisted of a cross-sectional study of age at menarche in two cohorts: adolescents (ages 11–24 years, n = 228) and adults (ages 19–55 years, n = 290, enrolled in the Coronary Artery Calcification in Type 1 Diabetes study). RESULTS The adolescent cohort reported a younger age of menarche than the adult women with type 1 diabetes (12.69 ± 0.08 vs. 13.22 ± 0.12 years, mean ± SE, P &amp;lt; 0.001). Age at menarche was later in both adolescent girls and adult women with type 1 diabetes diagnosed before menarche (12.82 ± 1.16 and 13.7 ± 2.23 years) than for individuals diagnosed after menarche (12.12 ± 1.25 and 12.65 ± 1.38 years, P &amp;lt; 0.001 for both). Age at menarche was then examined by decade of type 1 diabetes diagnosis (1970–1979, 1980–1989, 1990–1999, and 2000–2009). Age at menarche significantly declined over the 4 decades (P = 0.0002). However, the delay in menarche among girls diagnosed with type 1 diabetes before menarche compared with those diagnosed after menarche was also significant across all decades (P &amp;lt; 0.0001) and did not change significantly over time (P = 0.41 for interaction of cohort and diagnosis premenarche). CONCLUSIONS Age at menarche has declined over the past 4 decades among girls with type 1 diabetes, but a delay in age at menarche remains among individuals diagnosed before menarche compared with individuals diagnosed after menarche.
<i>IGF2BP1</i> Harbors Prognostic Significance by Gene Gain and Diverse Expression in Neuroblastoma
Authors: Jessica L. Bell, Raseswari Turlapati, Tao Liu, Johannes H. Schulte, Stefan Hüttelmaier
Journal: Journal of Clinical Oncology (2015)

Chromosomal 17q21-ter gain in neuroblastoma is both a common and prognostically significant event. The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) gene is located near the proximal edge of this region. Here, its prognostic value is evaluated in neuroblastoma.The mRNA expression of IGF2BP family members was first evaluated by microarray data sets. In addition, in a separate cohort of 69 tumors, IGF2BP1 gene copy number, mRNA, and protein abundance were determined and compared with clinical parameters.In two independent microarray data sets, 77% to 100% of tumors had substantial IGF2BP1 mRNA levels measured. High IGF2BP1 transcript abundance was significantly associated with stage 4 tumors (P < .001) and decreased patient survival (P < .001). IGF2BP1 was also associated with MYCN gene amplification and MYCN mRNA abundance. In the 69 neuroblastoma samples, IGF2BP1 DNA copy number (increased in 84% of tumors), mRNA, and protein abundance were significantly higher in stage 4 compared with stage 1 tumors. Importantly, IGF2BP1 protein levels were associated with lower overall patient survival (P = .012) and positively correlated with MYCN mRNA, even when excluding MYCN-amplified tumors. Moreover, IGF2BP1 clearly affected MYCN expression and neuroblastoma cell survival in vitro.In neuroblastoma, IGF2BP1 was expressed in the majority of neuroblastoma specimens analyzed and was associated with lower overall patient survival and MYCN abundance. These data demonstrate that IGF2BP1 is a potential oncogene and an independent negative prognostic factor in neuroblastoma.
Can the process of experimentation lead to greater happiness?
Authors: Simon C. Moore, Joselyn L. Sellen
Journal: Behavioral and Brain Sciences (2004)

We argue that the self-experimentation espoused by Roberts as a means of generating new ideas, particularly in the area of mood, may be confounded by the experimental procedure eliciting those affective changes. We further suggest that ideas might be better generated through contact with a broad range of people, rather than in isolation.
Cdc7 Kinase Is a Predictor of Survival and a Novel Therapeutic Target in Epithelial Ovarian Carcinoma
Authors: Anjana A. Kulkarni, Sarah R. Kingsbury, Slavica Tudzarova, Hye-Kyung Hong, Marco Loddo, Mohammed Rashid, Sara Rodriguez-Acebes, Andrew T. Prevost, Jonathan A. Ledermann, Kai Stoeber, Gareth H. Williams
Journal: Clinical Cancer Research (2009)

There is a lack of prognostic and predictive biomarkers in epithelial ovarian carcinoma, and the targeting of oncogenic signaling pathways has had limited impact on patient survival in this highly heterogeneous disease. The origin licensing machinery, which renders chromosomes competent for DNA replication, acts as a convergence point for upstream signaling pathways. We tested the hypothesis that Cdc7 kinase, a core component of the licensing machinery, is predictive of clinical outcome and may constitute a novel therapeutic target in epithelial ovarian carcinoma.A total of 143 cases of ovarian cancer and 5 cases of normal ovary were analyzed for Cdc7 protein expression dynamics and clinicopathologic features. To assess the therapeutic potential of Cdc7, expression was down-regulated by RNA interference in SKOV-3 and Caov-3 ovarian cancer cells.Increased Cdc7 protein levels were significantly associated with arrested tumor differentiation (P = 0.004), advanced clinical stage (P = 0.01), genomic instability (P < 0.001), and accelerated cell cycle progression. Multivariate analysis shows that Cdc7 predicts disease-free survival independent of patient age, tumor grade and stage (hazard ratio, 2.03; confidence interval, 1.53-2.68; P < 0.001), with the hazard ratio for relapse increasing to 10.90 (confidence interval, 4.07-29.17) for the stages 3 to 4/upper Cdc7 tertile group relative to stages 1 to 2/lower Cdc7 tertile tumors. In SKOV-3 and Caov-3 cells, Cdc7 siRNA knockdown triggered high levels of apoptosis, whereas untransformed cells arrest in G(1) phase and remain viable.Our findings show that Cdc7 kinase predicts survival and is a potent anticancer target in epithelial ovarian carcinoma, highlighting its potential as a predictor of susceptibility to small molecule kinase inhibitors currently in development.
Clinical assessment of disease activity in rheumatoid arthritis: evaluation of a functional test.
Authors: A A Kalla, T J Kotze, O L Meyers, N D Parkyn
Journal: Annals of the Rheumatic Diseases (1988)

A cross sectional analysis of the correlation between clinical, laboratory, and radiological markers of disease activity in 98 patients with classical rheumatoid arthritis (RA) is reported. The median age was 38 years, the median age at onset of disease 29 years, and the median duration of disease seven years. The Keitel function test (KFT) showed good correlation with the Ritchie articular index (RAI) (p less than 0.0001; r = 0.5) and the disability questionnaire (DQ) (p less than 0.0001; r = 0.6). The RAI and DQ correlated weakly with laboratory variables, while the KFT showed significant correlation with the erythrocyte sedimentation rate (ESR), C reactive protein (CRP), and plasma viscosity (PV) (p less than 0.001; r = 0.4; 0.3; 0.4). Only the KFT showed significant correlations with bone mass measurements (p less than 0.01; r = -0.3; -0.4), and the Larsen index at the right wrist (p less than 0.0001; r = 0.4). Consensus analysis suggested that the KFT is a useful single clinical test of disease activity in RA. The hand functional index (HFI), a component of the KFT, showed significant correlation with the total KFT (r = 0.9). Prospective drug trials are needed to establish the value of the HFI in the monitoring of patients with RA.
Myocardial Infarction in Rats Fed Diets Containing High Fat, Cholesterol, Thiouracil, and Sodium Cholate
Authors: WILBUR A. THOMAS, W. STANLEY HARTROFT
Journal: Circulation (1959)

Investigators have produced arteriosclerosis in experimental animals by dietary means for almost half a century. In contrast to the situation in man, however, all previous reports indicate that complicating thrombosis and infarction have been extremely rare in experimental animals. The current report presents dietary regimens by means of which the authors have produced significant numbers of myocardial and renal infarcts in rats (6 of 10 in one group and 4 of 10 in each of 2 others). It is notable that thrombosis occurred before the appearance of severe structural changes in the arterial walls, although abundant fat could often be demonstrated histochemically.
Immunization of Mice with Urease Vaccine Affords Protection against <i>Helicobacter pylori</i> Infection in the Absence of Antibodies and Is Mediated by MHC Class II–restricted Responses
Authors: Thomas H. Ermak, Paul J. Giannasca, Richard Nichols, Gwendolyn A. Myers, John Nedrud, Richard Weltzin, Cynthia K. Lee, Harold Kleanthous, Thomas P. Monath
Journal: The Journal of Experimental Medicine (1998)

We examined the roles of cell- and antibody-mediated immunity in urease vaccine–induced protection against Helicobacter pylori infection. Normal and knockout mice deficient in major histocompatibility complex (MHC) class I, MHC class II, or B cell responses were mucosally immunized with urease plus Escherichia coli heat-labile enterotoxin (LT), or parenterally immunized with urease plus aluminum hydroxide or a glycolipid adjuvant, challenged with H. pylori strain X47-2AL, and H. pylori organisms and leukocyte infiltration in the gastric mucosa quantified. In an adjuvant/route study in normal mice, there was a direct correlation between the level of protection and the density of T cells recruited to the gastric mucosa. In knockout studies, oral immunization with urease plus LT protected MHC class I knockout mice [β2-microglobulin (−/−)] but not MHC class II knockout mice [I-Ab (−/−)]. In B cell knockout mice [μMT (−/−)], vaccine-induced protection was equivalent to that observed in immunized wild-type (+/+) mice; no IgA+ cells were detected in the stomach, but levels of CD4+ cells equivalent to those in the wild-type strain (+/+) were seen. These studies indicate that protection of mice against H. pylori infection by immunization with the urease antigen is dependent on MHC class II–restricted, cell-mediated mechanisms, and antibody responses to urease are not required for protection.
Heparin-binding, Hemagglutinin-specific IFN-γ Synthesis at the Site of Infection during Active Tuberculosis in Humans
Authors: Sammy Place, Virginie Verscheure, Nour de San, Jean-Michel Hougardy, Kinda Schepers, Violette Dirix, Anne Dediste, Olivier Michel, Annie Drowart, Sabine D. Allard, T. Mark Doherty, Sophie Lecher, Camille Locht, Françoise Mascart
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: Tuberculosis (TB) remains a major cause of mortality. A better understanding of the immune responses to mycobacterial antigens may be helpful to develop improved vaccines and diagnostics.Objectives: The mycobacterial antigen heparin-binding hemagglutinin (HBHA) induces strong IFN-γ responses by circulating lymphocytes from subjects latently infected with Mycobacterium tuberculosis, and low responses associated with CD4+ regulatory T (Treg) cells in patients with TB. Here, we investigated HBHA-specific IFN-γ responses at the site of the TB disease.Methods: Bronchoalveolar lavages, pleural fluids, and blood were prospectively collected from 61 patients with a possible diagnosis of pulmonary or pleural TB. HBHA-specific IFN-γ production was analyzed by flow cytometry and ELISA. The suppressive effect of pleural Treg cells was investigated by depletion experiments.Measurements and Main Results: The percentages of HBHA-induced IFN-γ+ alveolar and pleural lymphocytes were higher for pulmonary (P < 0.0001) and for pleural (P < 0.01) TB than for non-TB controls. Local CD4+ and CD8+ T cells produced the HBHA-specific IFN-γ. This local secretion was not suppressed by Treg lymphocytes, contrasting with previously reported data on circulating lymphocytes.Conclusions: Patients with TB display differential effector and regulatory T-cell responses to HBHA in local and circulating lymphocytes with a predominant effector CD4+ and CD8+ response locally, compared with a predominant Treg response among circulating lymphocytes. These findings may be helpful for the design of new vaccines against TB, and the detection of HBHA-specific T cells at the site of the infection may be a promising tool for the rapid diagnosis of active TB.