tbuckley/cabot-search huggingface dataset:
Harnessing Hierarchical Nano‐ and Micro‐Fabrication Technologies for Musculoskeletal Tissue Engineering
Authors: Sunny A. Abbah, Luis M. Delgado, Ayesha Azeem, Kieran Fuller, Naledi Shologu, Michael Keeney, Manus J. Biggs, Abhay Pandit, Dimitrios I. Zeugolis
Journal: Advanced Healthcare Materials (2015)

Cells within a tissue are able to perceive, interpret and respond to the biophysical, biomechanical, and biochemical properties of the 3D extracellular matrix environment in which they reside. Such stimuli regulate cell adhesion, metabolic state, proliferation, migration, fate and lineage commitment, and ultimately, tissue morphogenesis and function. Current scaffold fabrication strategies in musculoskeletal tissue engineering seek to mimic the sophistication and comprehensiveness of nature to develop hierarchically assembled 3D implantable devices of different geometric dimensions (nano- to macrometric scales) that will offer control over cellular functions and ultimately achieve functional regeneration. Herein, advances and shortfalls of bottom-up (self-assembly, freeze-drying, rapid prototype, electrospinning) and top-down (imprinting) scaffold fabrication approaches, specific to musculoskeletal tissue engineering, are discussed and critically assessed.
American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer
Authors: Debbie Saslow, Diane Solomon, Herschel W. Lawson, Maureen Killackey, Shalini L. Kulasingam, Joanna Cain, Francisco A. R. Garcia, Ann T. Moriarty, Alan G. Waxman, David C. Wilbur, Nicolas Wentzensen, Levi S. Downs, Mark Spitzer, Anna‐Barbara Moscicki, Eduardo L. Franco, Mark H. Stoler, Mark Schiffman, Philip E. Castle, Evan R. Myers
Journal: CA A Cancer Journal for Clinicians (2012)

An update to the American Cancer Society (ACS) guideline regarding screening for the early detection of cervical precancerous lesions and cancer is presented. The guidelines are based on a systematic evidence review, contributions from 6 working groups, and a recent symposium cosponsored by the ACS, the American Society for Colposcopy and Cervical Pathology, and the American Society for Clinical Pathology, which was attended by 25 organizations. The new screening recommendations address age-appropriate screening strategies, including the use of cytology and high-risk human papillomavirus (HPV) testing, follow-up (eg, the management of screen positives and screening intervals for screen negatives) of women after screening, the age at which to exit screening, future considerations regarding HPV testing alone as a primary screening approach, and screening strategies for women vaccinated against HPV16 and HPV18 infections.
Alzheimer's Disease: Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid‐β Aggregates (Adv. Healthcare Mater. 14/2015)
Authors: Colleen N. Loynachan, Gabriela Romero, Michael G. Christiansen, Ritchie Chen, Rachel Ellison, Tiernan T. O'Malley, Ulrich P. Froriep, Dominic M. Walsh, Polina Anikeeva
Journal: Advanced Healthcare Materials (2015)

On p. 2100, P. Anikeeva and co-workers demonstrate a technique using remotely triggered local heating to disaggregate deposits of the protein Aβ(1–42), which plays an important role in Alzheimer's Disease pathogenesis. The cover image shows neural network (green) overlayed with amyloid beta plaques (red) that are decorated with magnetic nanoparticles (blue). The glow around the blue spheres represents heat dissipation by nanoparticles, which induces disaggregation of the plaques.
Decrease in number of genital chlamydia cases in Norrbotten, Sweden, October – November 2009: an indirect effect of pandemic influenza A(H1N1)?
Authors: A Österlund
Journal: Eurosurveillance (2010)

A sudden reduction in the number of reported genital chlamydia cases was observed in Norrbotten County, Sweden, during October to November 2009. After exploring other possibilities, such as a reduction in the number of chlamydia tests analysed or a new Chlamydia trachomatis variant that had been undetected in standard laboratory tests, it was found likely that the decrease was an indirect effect of the 2009 influenza A(H1N1) pandemic due to reduced social interactions among young adults.
Is iron treatment beneficial in, iron-deficient but non-anaemic (IDNA) endurance athletes? A systematic review and meta-analysis
Authors: Richard J Burden, Katie Morton, Toby Richards, Gregory P Whyte, Charles R Pedlar
Journal: British Journal of Sports Medicine (2014)

Purpose The aim of this study was to determine whether iron treatments improve the iron status and aerobic capacity of iron deficient non-anaemic endurance athletes. Method A meta-analysis of studies that investigated the effects of iron treatment on serum ferritin (sFer), serum iron (sFe), transferrin saturation (Tsat), haemoglobin concentration ([Hb]) and ( ). Seventeen eligible studies were identified from online databases. Results Analysis of pooled data indicated that iron treatments had a large effect on improving sFer (Hedges’ g=1.088, 95% CI 0.914 to 1.263, p&lt;0.001), sFe (Hedges’ g=1.004, 95% CI 0.828 to 1.181, p&lt;0.001) and Tsat (Hedges g=0.741, 95% CI 0.564 to 0.919, p&lt;0.001) and a moderate effect on improving [Hb] (Hedges’ g=0.695, 95% CI 0.533 to 0.836, p&lt;0.001) and (Hedges’ g=0.610, 95% CI 0.399 to 0.821, p &lt;0.001). Regression analysis revealed a significant interaction between the effect of iron treatment on sFer and treatment duration, suggesting treatments that lasted beyond 80 days appear to have the least effect on sFer. Conclusions These results indicate iron treatments improve the iron status and aerobic capacity of iron deficient non-anaemic endurance athletes.
The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: Clinical and regulatory implications Report on a Policy Conference of the European Society of Cardiology
Authors: W Haverkamp*
Journal: Cardiovascular Research (2000)

1 1.Preamble mal presentations.The speakers were chosen for their particular competence in the relevant field.Furthermore, The Policy Conference on The Potential for QT selected topics were discussed in detail in separate work-Prolongation and Pro-arrhythmia by Non-anti-arrhythmic shops.This document represents the executive summary of Drugs.
Long-term outcomes of stenting as a bridge to surgery for acute left-sided malignant colonic obstruction.
Authors: Fayez A. Quereshy, Jensen T.C. Poon, Wai Lun Law
Journal: Journal of Clinical Oncology (2012)

e14032 Background: Stenting as a bridge to surgery has been increasingly applied in cases of acute left-sided colonic obstruction. This study aims to evaluate both the short and long-term outcomes associated with colonic stenting as a bridge to surgery in patients with obstructing adenocarcinoma of the colon. Methods: Patients with potentially curable acute left-sided colonic obstruction treated with stenting as a bridge to surgery (28) or with emergency surgical resection (39) from January 1998 to December 2008 were identified using a prospectively maintained database. Short-term data on post-operative mortality, morbidity, necessity of intensive care, and length of hospital stay were compared. Disease-free and overall survival data were also analyzed. Results: Patients within the two study arms had similar demographic profiles. Patients receiving preoperative stenting had a higher likelihood of a laparoscopic resection (p&lt;0.001). Further, the emergency surgery group had a higher rate of post-operative complications (p=0.024), rate of ICU admission (p=0.013), and longer total length of stay (9 vs. 12 days, p=0.001). With a median follow-up of 26.5 and 31.3 months for the stenting and surgical resection groups respectively, there was no difference in overall and disease-free survival (overall survival = 30 vs. 31 months, p=0.858; DFS = 13 vs. 12 months, p=0.989). As well, there was no difference in the rate of systemic recurrences (8 vs. 13, p=0.991). Conclusions: Stenting as a bridge to surgery is a safe treatment strategy in the management of patients with acute left-sided colonic obstruction with improved short-term outcomes and comparable long-term oncologic results.
Preparation of antioxidant film from Musa sapientum Linn. peel extract and fruit
Authors: Saengrawee Sutthiparinyanont, Nutthiya Panrattanasukkul, Siriwatjanee Katasila, Saran Panyajai, Anongnart Kamkeaw, Padungkwan Chitropas
Journal: Asian Journal of Pharmaceutical Sciences (2015)
A prospective study of total plasma cell-free DNA as a predictive biomarker for response to systemic therapy in patients with advanced non-small-cell lung cancers
Authors: B.T. Li, A. Drilon, M.L. Johnson, M. Hsu, C.S. Sima, C. McGinn, H. Sugita, M.G. Kris, C.G. Azzoli
Journal: Annals of Oncology (2015)
Abstract 3736: Assessment of tobacco use within 30 days increases referral for cessation support
Authors: Samuel Lewis Cooper, Katherine Hoover, Elizabeth Garrett-Mayer, Kenneth Michael Cummings, Matthew J. Carpenter, Kelly Crowley, David T. Marshall, Graham W. Warren
Journal: Cancer Research (2015)

Abstract Background: Cancer patients who self-report tobacco use within the past 30 days are at high risk for relapse and benefit from cessation support. However, there is little data on whether assessment of tobacco use within the past 30 days increases referral rates to a cessation program across cancer disease sites. Methods: Structured tobacco assessments were administered to 426 new adult patients in a Radiation Oncology clinic at a single institution. Multiple logistic regression was used to assess if clinical aspects of cancer diagnosis (age, gender, race, disease site [head/neck or thoracic {HNT} vs. other], stage [advanced vs. early], and purpose [curative vs. palliative]) affected cessation service referral rates identified using assessment of tobacco use within the past 30 days. Results: Complete medical and tobacco use data were compiled for 387 adult cancer patients (91%). Of these, 147 (38%) were women, 259 (67%) were Caucasian, 115 (30%) were black, 177 (46%) were diagnosed with HNT cancer, and 289 (74%) were being considered for curative cancer treatment. Ever smoking was reported in 273 patients (71%), and 83 (21%) reported current smoking everyday or some days. In 180 former smokers who reported time since last cigarette, 21 (12%) reported smoking within with past 30 days and 9 (7%) of these reported smoking within the past day or week. In 21 patients who were identified for cessation support through evaluation of smoking within the past 30 days, 6 (29%) were women, 7 (33%) were black, 15 (71%) were being considered for curative treatment, and 15 (71%) were diagnosed with a HNT cancer. Multiple logistic regression identified that younger age (10 yr OR 2.41, 95% CI 1.47 - 3.98) and HNT cancer (OR 8.13, 95% CI 2.2-30.3) but not gender, race, stage, and purpose were significantly associated with referral based on assessment of tobacco use within the past 30 days. Identification of smoking within the past 30 days increased cessation referrals by 25% from 83 to 114 patients. Conclusions: Assessment of tobacco use within the past 30 days increased referrals to a smoking cessation program from a Radiation Oncology clinic using a standardized tobacco assessment. In clinical trials and practice, including this question has particular benefit for younger patients and patients with head/neck or thoracic tumors. Citation Format: Samuel Lewis Cooper, Katherine Hoover, Elizabeth Garrett-Mayer, Kenneth Michael Cummings, Matthew J. Carpenter, Kelly Crowley, David T. Marshall, Graham W. Warren. Assessment of tobacco use within 30 days increases referral for cessation support. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3736. doi:10.1158/1538-7445.AM2015-3736
Obstacles to establishing an NHS faecal transplant programme
Authors: B. H. Mullish, H. R. T. Williams
Journal: BMJ (2015)

Having recently established a faecal microbiota transplantation (FMT) programme, we raise two points about Spector and Knight’s editorial on FMT.1

Firstly, despite the UK’s relatively permissive regulatory framework on FMT, we encountered considerable obstacles to establishing an NHS programme. Donor screening is expensive (>£500 (€703; $755)/screen/donor, repeated regularly). It is unclear …
Treatment of Hepatitis C Virus Infection in Real Life
Authors: Hal F. Yee
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Report of the European Respiratory Society/European Cystic Fibrosis Society task force on the care of adults with cystic fibrosis
Authors: J. Stuart Elborn, Scott C. Bell, Susan L. Madge, Pierre-Regis Burgel, Carlo Castellani, Steven Conway, Karleen De Rijcke, Birgit Dembski, Pavel Drevinek, Harry G.M. Heijerman, J. Alistair Innes, Anders Lindblad, Bruce Marshall, Hanne V. Olesen, Andreas L. Reimann, Ampara Solé, Laura Viviani, Thomas O.F. Wagner, Tobias Welte, Francesco Blasi
Journal: European Respiratory Journal (2015)

The improved survival in people with cystic fibrosis has led to an increasing number of patients reaching adulthood. This trend is likely to be maintained over the next decades, suggesting a need to increase the number of centres with expertise in the management of adult patients with cystic fibrosis. These centres should be capable of delivering multidisciplinary care addressing the complexity of the disease, in addition to addressing the psychological burden on patients and their families. Further issues that require attention are organ transplantation and end of life management. Lung disease in adults with cystic fibrosis drives most of the clinical care requirements, and major life-threatening complications, such as respiratory infection, respiratory failure, pneumothorax and haemoptysis, and the management of lung transplantation require expertise from trained respiratory physicians. The taskforce therefore strongly reccommends that medical leadership in multidisciplinary adult teams should be attributed to a respiratory physician adequately trained in cystic fibrosis management. The task force suggests the implementation of a core curriculum for trainees in adult respiratory medicine and the selection and accreditation of training centres that deliver postgraduate training to the standards of the HERMES programme.
Immune activation caused by vascular oxidation promotes fibrosis and hypertension
Authors: Jing Wu, Mohamed A. Saleh, Annet Kirabo, Hana A. Itani, Kim Ramil C. Montaniel, Liang Xiao, Wei Chen, Raymond L. Mernaugh, Hua Cai, Kenneth E. Bernstein, Jörg J. Goronzy, Cornelia M. Weyand, John A. Curci, Natalia R. Barbaro, Heitor Moreno, Sean S. Davies, L. Jackson Roberts, Meena S. Madhur, David G. Harrison
Journal: Journal of Clinical Investigation (2015)

Vascular oxidative injury accompanies many common conditions associated with hypertension. In the present study, we employed mouse models with excessive vascular production of ROS (tgsm/p22phox mice, which overexpress the NADPH oxidase subunit p22phox in smooth muscle, and mice with vascular-specific deletion of extracellular SOD) and have shown that these animals develop vascular collagen deposition, aortic stiffening, renal dysfunction, and hypertension with age. T cells from tgsm/p22phox mice produced high levels of IL-17A and IFN-γ. Crossing tgsm/p22phox mice with lymphocyte-deficient Rag1–/– mice eliminated vascular inflammation, aortic stiffening, renal dysfunction, and hypertension; however, adoptive transfer of T cells restored these processes. Isoketal-protein adducts, which are immunogenic, were increased in aortas, DCs, and macrophages of tgsm/p22phox mice. Autologous pulsing with tgsm/p22phox aortic homogenates promoted DCs of tgsm/p22phox mice to stimulate T cell proliferation and production of IFN-γ, IL-17A, and TNF-α. Treatment with the superoxide scavenger tempol or the isoketal scavenger 2-hydroxybenzylamine (2-HOBA) normalized blood pressure; prevented vascular inflammation, aortic stiffening, and hypertension; and prevented DC and T cell activation. Moreover, in human aortas, the aortic content of isoketal adducts correlated with fibrosis and inflammation severity. Together, these results define a pathway linking vascular oxidant stress to immune activation and aortic stiffening and provide insight into the systemic inflammation encountered in common vascular diseases.
Urinary N-acetyl-beta-D-glucosaminidase and serum creatinine concentrations predict impaired excretion of methotrexate.
Authors: M P Goren, R K Wright, M E Horowitz, W R Crom, W H Meyer
Journal: Journal of Clinical Oncology (1987)

We determined the risk of impaired excretion of methotrexate (MTX) in children with osteosarcoma, who also were receiving cisplatin, by analyzing urinary markers of renal tubular damage, as well as serum creatinine measured before each dose of MTX. MTX clearance was impaired in seven of the ten patients studied after cisplatin therapy. Patients with a urinary N-acetyl-beta-D-glucosaminidase (NAG) concentration of greater than 1.5 U/mmol creatinine or a greater than 50% increase in serum creatinine relative to the pretherapy level were approximately 30 times more likely to have MTX half-lives greater than 3.5 hours than were patients with lower values for these markers; MTX clearance was always impaired if both markers were elevated. If neither urinary NAG nor serum creatinine concentrations increased, the risk of impaired MTX excretion was negligible. Our findings demonstrate that urinary NAG and serum creatinine levels, measured before MTX administration, can be used to identify patients who will have difficulty in clearing the drug.
Comparative Susceptibility of the Lymphoid Tissues of Strain C57 Black Mice to the Induction of Lymphoid Tumors by Irradiation&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: H S KAPLAN
Journal: JNCI Journal of the National Cancer Institute (1948)
RNA and Protein Metabolism in the Aging Brain
Authors: C E Finch, D G Morgan
Journal: Annual Review of Neuroscience (1990)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Review of L. Pessini, C. de Paul de Barchifontaine, and F. Lolas (eds.).<i>Perspectivas de la Bioética en Iberoamérica [Ibero-American Perspectives on Bioethics]</i>.<sup>1</sup>
Authors: Antonio Casado da Rocha
Journal: The American Journal of Bioethics (2008)

"Review of L. Pessini, C. de Paul de Barchifontaine, and F. Lolas (eds.). Perspectivas de la Bioética en Iberoamérica [Ibero-American Perspectives on Bioethics]. 1 ." , 8(4), pp. 74–75
Islet Transplantation in Treating Diabetes
Authors: P E Lacy, D W Scharp
Journal: Annual Review of Medicine (1986)

Remarkable progress made in the past few years has brought pancreatic islet transplantation to the threshold of human clinical trials. Islet transplants have reversed diabetes in experimental animals and prevented or reversed early diabetic complications in the recipients. Methods have been developed that prevent rejection of islets transplanted across major histocompatibility barriers in rodents without requiring the continuous use of immunosuppressive drugs to maintain the transplants. A new method has been developed for isolating 40% of the islets from a single human pancreas. Based upon these accomplishments, the first phase of human clinical trials on islet transplantation was initiated during the past few months.
Metagenomic cross-talk: the regulatory interplay between immunogenomics and the microbiome
Authors: Maayan Levy, Christoph A. Thaiss, Eran Elinav
Journal: Genome Medicine (2015)

The human microbiome, often referred to as the 'second genome', encompasses up to 100-fold more genes than the host genome.In contrast to the human genome, the microbial genome is flexible and amenable to change during the host's lifetime.As the composition of the microbial metagenome has been associated with the development of human disease, the mechanisms controlling the composition and function of the metagenome are of considerable interest and therapeutic potential.In the past few years, studies have revealed how the host immune system is involved in determining the microbial metagenome, and, in turn, how the microbiota regulates gene expression in the immune system.This species-specific bidirectional interaction is required for homeostatic health, whereas aberrations in the tightly controlled regulatory circuits that link the host immunogenome and the microbial metagenome drive susceptibility to common human diseases.Here, we summarize some of the major principles orchestrating this cross-talk between microbial and host genomes, with a special focus on the interaction between the intestinal immune system and the gut microbiome.Understanding the reciprocal genetic and epigenetic control between host and microbiota will be an important step towards the development of novel therapies against microbiome-driven diseases.The bi-directional interaction between microbial and host genomes
Dual growth factor-immobilized microspheres for tissue reinnervation
Authors: Tae Ho Kim, Se Heang Oh, Dan Bi An, Jin Ho Lee
Journal: Asian Journal of Pharmaceutical Sciences (2015)

G factors [basic fibroblast growth factor (bFGF) and/or nerve growth factor (NGF)]-immobilized polycaprolactone (PCL)/ Pluronic F127 microspheres were prepared using an isolated particulate-melting method and the sequential binding of heparin and growth factors (GFs) onto the microspheres. The GFs immobilized on the microspheres were released in a sustained manner over 28 days, regardless of GF type. From the in vitro culture of muscle derived stem cells, it was observed that the NGF-immobilized microspheres induced more neurogenic differentiation than the bFGF-immobilized microspheres as evidenced by a quantitative real time polymerase chain reaction using specific neurogenic markers (Nestin, GFAP, β-tubulin and MAP2) and Western blot (markers, Nestin and β-tubulin)] analyses. The dual bFGF/NGF-immobilized microspheres showed better neurogenic differentiation than the microspheres immobilized with single bFGF or NGF. From the preliminary animal study, the dual bFGF/NGF-immobilized microsphere group also showed effective nerve regeneration as evaluated by immunocytochemistry using a marker, β-tubulin. The dual bFGF/NGF-immobilized PCL/Pluronic F127 microspheres may be a promising candidate for nerve regeneration in certain target tissues (i.e., muscles) leading to sufficient reinnervation.