tbuckley/cabot-search huggingface dataset:
Safety and efficacy trial of cisplatin (P) with vinorelbine (V) followed by gefitinib (G) and concurrent thoracic radiotherapy (TRT) for unresectable locally advanced non-small cell lung cancer (LA-NSCLC): Japan Clinical Oncology Group (JCOG) 0402.
Authors: Y. Ohe, Y. Nishiwaki, A. Yokoyama, M. Kawahara, K. Takeda, T. Shibata, T. Tamura, N. Saijo, M. Fukuoka
Journal: Journal of Clinical Oncology (2010)

7084 Background: JCOG0402 was conducted to evaluate safety and efficacy of P with V followed by G and TRT for unresectable LA-NSCLC. Methods: The pts received induction chemotherapy with P (80mg/m2, d1 and 22) and V (25mg/m2, d1, 8, 22, 29) followed by G (250mg, beginning on d43) and TRT (60Gy/30fr, d57-98). G was continued for 1 year if neither unacceptable toxicity nor tumor progression were observed. The primary endpoint was feasibility, which was defined as the proportion of pts who completed the TRT treatment (60Gy) and received more than 75% of the planned dose of G, without developing grade 2 or worse pneumonitis. The sample size was determined to be 37, with a one-sided alpha of 0.1 and a beta of 0.1; the expected and threshold values for the primary endpoints were 75% and 55%. Results: From Oct 2004 to Sep 2008, 38 pts (14 men, 24 women) with LA-NSCLC were enrolled from 12 hospitals in Japan. Most of the pts were Japanese and were never or light smokers. The median age was 59.5 years (30-69 years); PS 0: 29, 1: 9; adenocarcinoma: 37, P/D carcinoma: 1. Two pts developed grade 2 or worse pneumonitis and G was suspended in 14 pts because of transient toxicity. Of the 38 pts, 23 pts (61%) completed treatment without experiencing grade 2 or worse pneumonitis; this percentage was slightly less than our previously defined criterion for treatment feasibility. During the concurrent phase of G and TRT, grade 3/4 transaminase elevations were observed in 31%/6% of the pts, respectively. All other toxicities were relatively mild. Efficacy was evaluated among 37 pts. The overall response rate was 73% (95%CI: 56∼86%, 1CR, 26PR) and the MST was 28.1 months. The 1-, 2-, 3-year survival rates were 94%, 61%, 36%, respectively. Conclusions: P with V followed by G and TRT was effective among highly select pts with unresectable LA-NSCLC. Although the results did not meet our criterion for feasibility, the toxicity level was acceptable. P with V followed by G and TRT might warrant further evaluation among select pts, such as EGFR mutation positive LA-NSCLC. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca, Bristol-Myers Squibb, Kyowa Hakko Kirin
Lesbian, Gay, Bisexual, and Transgender Health Disparities
Authors: Mark D. Lacy
Journal: Annals of Internal Medicine (2015)

Letters15 December 2015Lesbian, Gay, Bisexual, and Transgender Health DisparitiesMark D. Lacy, MD, MAMark D. Lacy, MD, MAFrom Texas Tech University, Lubbock, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5185 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:To advocate for the elimination of health care disparities among LGBT persons is a worthy objective for not only this population but all patients facing obstacles to quality care. Sadly, ACP's position paper (1) goes beyond advocating for health care access by promoting a damaging sociopolitical ideology. This paper redefines the meaning of family and marriage and calls for denying LGBT persons choices in behavioral health services.Although ACP alleges that this paper was produced after review of “numerous studies, reports, and surveys on LGBT health care and related health policy,” many cited references are based on ...References1. Daniel H, Butkus R; Health and Public Policy Committee of American College of Physicians. Lesbian, gay, bisexual, and transgender health disparities: executive summary of a policy position paper from the American College of Physicians. Ann Intern Med. 2015;163:135-7. [PMID: 25961598]. doi:10.7326/M14-2482 LinkGoogle Scholar2. Blaisdell B, eds. G.K. Chesterton Quotes. Mineola, NY: Dover; 2015. Google Scholar Author, Article, and Disclosure InformationAuthors: Mark D. Lacy, MD, MAAffiliations: From Texas Tech University, Lubbock, Texas.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0477. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLesbian, Gay, Bisexual, and Transgender Health Disparities: Executive Summary of a Policy Position Paper From the American College of Physicians Hilary Daniel and Renee Butkus , for the Health and Public Policy Committee of the American College of Physicians* Lesbian, Gay, Bisexual, and Transgender Health Disparities Hilary Daniel , Renee Butkus , and Darilyn V. Moyer Lesbian, Gay, Bisexual, and Transgender Health Disparities Henry H. Ng Metrics Cited byBeyond Sensitivity. LGBT Healthcare Training in U.S. Medical Schools: A Review of the Literature 15 December 2015Volume 163, Issue 12Page: 962-963KeywordsDisclosureHealth careHealth care policy reportsHealth disparitiesHealth surveysHuman sexual behaviorLGBTQMedical servicesPatient advocacyThrombosis ePublished: 15 December 2015 Issue Published: 15 December 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Randomized Phase III Trial in Non-Transplant Eligible Patients with Newly Diagnosed Symptomatic Multiple Myeloma Comparing Melphalan-Prednisone-Thalidomide Followed By Thalidomide Maintenance (MPT-T) Versus Melphalan-Prednisone-Lenalidomide Followed By Maintenance with Lenalidomide (MPR-R); A Joint Study of the Dutch-Belgian Cooperative Trial Group for Hematology Oncology (HOVON) and the Nordic Myeloma Study Group (NMSG)
Authors: Sonja Zweegman, Bronno van der Holt, Ulf-Henrik Mellqvist, Morten Salomo, Gerard M.J. Bos, Mark-David Levin, Heleen A Visser-Wisselaar, Markus Hansson, Annette WG van der Velden, Wendy Deenik, Astrid Gruber, Juleon LLM Coenen, Torben Plesner, Saskia K Klein, Bea Tanis, Damian L Szatkowski, Rolf Brouwer, Matthijs Westerman, M (Rineke) BL Leys, Niels W.C.J. van de Donk, Einar Haukås, Klaas van der Hem, MF Durian, E (Vera) JM Mattijssen, Harm AM Sinnige, Marian JPL Stevens-Kroef, Pieter Sonneveld, Anders Waage
Journal: Blood (2014)
Abstract 9518: Role for Mir-126 in Right Ventricle Failure in Pulmonary Arterial Hypertension
Authors: francois potus, simon Malenfant, Sandra Breuils Bonnet, roxane Paulin, Pasquale Ferrero, Evangelos michelakis, Steeve Provencher, Sébastien Bonnet
Journal: Circulation (2014)

Rationale: Pulmonary arterial hypertension (PAH) is characterized by 1) pulmonary vascular lesions leading to increased pulmonary vascular resistance; 2) right ventricle (RV) microcirculation rarefaction contributing to its failure and 3) decrease skeletal muscle perfusion sustaining exercise intolerance. There is growing evidence that impaired angiogenesis could be a common denominator to this triad of abnormalities. An impaired endothelial function is recognized as the major trigger for PAH, although the mechanism remains unclear. MicroRNAs have emerged as major players in PAH pathogenesis. Thus we hypothesized that miR-126, an endothelial-specific pro-angiogenic microRNA is downregulated in PAH contributing to the pulmonary, RV and skeletal muscle abnormalities. Methods and Results: By qRT-PCR, we showed that miR-126 is down regulated in lungs, RV and skeletal muscles of PAH patients (n=10 to 20; p<0.01) compared to non-PAH donors. This correlates with a reduction of microcirculation (CD31 staining; p<...
Growth Inhibitory Activity in the Supernatants of Nondividing WI-38 Cells
Authors: E. Garcia-Giralt, L. Berumen, A. Macieira-Coelho
Journal: JNCI Journal of the National Cancer Institute (1970)

When human WI-38 cell cultures were released from growth inhibition under conditions of cell crowding by medium renewal, a large number of cells responded to the first medium change, the cell population increased, though some cells eventually detached, the capacity to be stimulated was progressively exhausted after repeated renewals of medium, and only part of the population responded to further stimulation. The exhaustion of the division potential could be delayed if the cell layer was washed before addition of fresh medium. Supernatants of cultures that no longer responded to medium renewals were inhibitory for the growth of actively growing cultures. The findings suggest that the exhaustion of the division potential after repeated stimulations was due to the progressive accumulation of an inhibitor.
Study and characterization of mutated antigen specific T cells isolated from fresh tumor and peripheral lymphocytes in cancer patients
Authors: Cyrille Cohen, Jared J Gartner, Miryam Horovitz-Fried, Katerina Shamalov, Kasia Trebska-Mcgowan, Valery Bliskovsky, Maria R Parkhurst, Chen Ankri, Todd D Prickett, Jessica Crystal, Yong Li, Mona El-Gamil, Steven A Rosenberg, Paul F Robbins
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts T cell-based immunotherapy shows promise for the successful treatment of advanced cancer. Indeed, adoptively transferred tumor infiltrating T lymphocytes (TIL) that mediated complete regression of metastatic melanoma have been shown to recognize neoantigens/mutated epitopes
Early market access of cancer drugs in the EU
Authors: J. Martinalbo, D. Bowen, J. Camarero, M. Chapelin, P. Démolis, P. Foggi, B. Jonsson, J. Llinares, A. Moreau, D. O'Connor, J. Oliveira, S. Vamvakas, F. Pignatti
Journal: Annals of Oncology (2015)
Abstract P292: Adverse Childhood Events Are Linked To Cardiovascular and Lung Disease Among Women In Hawaii: The Behavioral Risk Factor Surveillance System Survey, 2010
Authors: Rosemay A Remigio-Baker, Donald K Hayes
Journal: Circulation (2014)

Introduction: Cardiovascular disease ( CVD ), which includes heart disease and stroke, account for about 30% of mortality in Hawaii and affect more women than men. In addition, lung disease ( LD ) (e.g. chronic obstructive pulmonary disease [ COPD ]) continues to rise in the state with a death rate that is also higher among women. Little is known about the association between adverse childhood events ( ACEs ) and CVD or LD among women in Hawaii. Further, although the LD-CVD association has been established, the influence of ACEs in this relationship has yet to be evaluated. HYPOTHESES: We assessed the hypothesis that the type of ACEs (household dysfunction and physical, verbal and sexual abuse) will be positively associated with CVD and LD, and that the LD-CVD association will vary by the presence of ACEs. Methods: Data on 3,477 women residing in Hawaii from the Behavioral Risk Factor Surveillance System Survey was used to examine the relationship between ACEs and CVD (coronary heart disease [ CHD ], myocardial infarction [ MI ], stroke), or LD (COPD, asthma) using multivariable logistic regression, taking into account sampling method. The LD-CVD association was also investigated, with ACE types evaluated as potential modifiers. CVD and LD were assessed as individual ailments (e.g. CHD, COPD) and combined (any CVD, any LD). Covariates included socio-demographics, health behaviors (current smoking status, binge drinking), emotional support, BMI and current depressive symptoms status. Results: Evaluation by ACE type revealed a significant relationship between household dysfunction and CHD (OR=2.6, CI=1.4, 5.0) and any CVD (OR=1.8, CI=1.2, 2.7). Physical abuse was also found associated with COPD (OR=2.1, CI=1.3, 3.6), while verbal abuse was found related with asthma (OR=1.6, CI=1.2, 2.2) and any LD (OR=1.6, CI=1.2, 2.1). Further, physical abuse modified the association between COPD and MI (p=0.003) or any CVD (p=0.042), with a positive association found in the absence but not the presence of physical abuse (OR=3.9 vs. 0.1 and 2.9 vs. 0.7, respectively). The same trend was found for sexual abuse in the asthma-MI relationship (OR=2.6 vs. 0.5). Noteworthy was that individuals who did not report childhood physical or sexual abuse were more likely to have diabetes than those reporting abuse (p&lt;0.05 for both ACE). Conclusions: In conclusion, it might be of benefit to investigate the presence of ACEs, particularly household dysfunction and physical and verbal abuse, in treating CVD or LD among women in Hawaii. Decreasing the prevalence of ACEs might also lower CVD or LD morbidity and mortality in this population. Although the COPD-MI, or any CVD, and asthma-MI associations were significantly positive only among those who reported physical or sexual abuse, respectively, this cohort had a greater prevalence of diabetes, which might influence these relationships. These findings warrant further investigation.
Hyperplastic and Metaplastic Responses of Human Mammary Fibroadenomas and Dysplasias in Organ Culture2
Authors: Joel J. Elias, Rosa C. Armstrong
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Hyperplastic and Metaplastic Responses of Human Mammary Fibroadenomas and Dysplasias in Organ Culture Get access Joel J. Elias, Joel J. Elias Search for other works by this author on: Oxford Academic PubMed Google Scholar Rosa C. Armstrong Rosa C. Armstrong Department of Anatomy, University of California Medical Center, San Francisco, Calif. 94143 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 4, October 1973, Pages 1341–1343, https://doi.org/10.1093/jnci/51.4.1341 Published: 01 October 1973 Article history Received: 29 May 1973 Accepted: 25 June 1973 Published: 01 October 1973
Abstract 19340: Advanced Peripheral Endothelial Dysfunction Correlates with Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Left Ventricular Ejection Fraction in Hypertensive Patients
Authors: Eiichi Akiyama, Seigo Sugiyama, Yasushi Matsuzawa, Hiroyuki Suzuki, Masaaki Konishi, Naoki Nakayama, Hirofumi Kurokawa, Kouichirou Fujisue, Toshimitsu Nozaki, Keisuke Ohba, Junichi Matsubara, Koichi Sugamura, Hitoshi Sumida, Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
Journal: Circulation (2014)

Background: Left ventricular (LV) diastolic dysfunction (DD) and vascular functions including peripheral endothelial function play an important role in the pathogenesis of heart failure (HF) with preserved LV ejection fraction (EF) (HFPEF). Hypertension is the most important risk factor in HFPEF and the increased workload caused by hypertension results in LV pathological hypertrophy and LVDD. However, the importance of endothelial function in hypertensive patients with LVDD or HFPEF remains yet undetermined. We investigated the association between peripheral endothelial function, LVDD, and HFPEF in hypertensive patients. Methods and Results: We evaluated cardiac function by echocardiography measuring the ratio of early transmitral flow velocity to tissue Doppler early diastolic mitral annular velocity (E/e’) and LVEF. We also noninvasively assessed peripheral endothelial function by reactive hyperemia-peripheral arterial tonometry (RH-PAT) as the RH-PAT index(RHI) in 405 hypertensive patients with preserved LVEF (LVEF&gt;50%), comprising 180 HFPEF and 225 non-HF patients (LVDD; E/e’&gt;15, non-HF with LVDD; n=98, non-HF without LVDD; n=127). RHI negatively correlated with E/e’ (r=-0.24, P&lt;0.001) and B-type natriuretic peptide (r=-0.19, P&lt;0.001). RHI was significantly lower in hypertensive patients with HFPEF than in non-HF hypertensive patients (0.49±0.17 vs. 0.62±0.20, P&lt;0.001). Furthermore, RHI was significantly lower in non-HF hypertensive patients with LVDD than those without LVDD (0.58±0.19 vs. 0.65±0.21, P=0.01). Multivariate logistic regression analysis identified that lower RHI independently correlated with the presence of HFPEF in hypertensive patients with preserved LVEF (odds ratio: 0.65, 95% confidence interval: 0.55-0.77, P&lt;0.001) and with the presence of LVDD in non-HF hypertensive patients (odds ratio: 0.65, 95% confidence interval: 0.71-0.95, P=0.01). Conclusions: RHI was independently associated with the presence of HFPEF and LVDD in hypertensive patients with preserved LVEF. Endothelial dysfunction in microcirculation could play a crucial role in the pathogenesis of LVDD and HFPEF in hypertensive patients.
Deletions in the Long Arm of Chromosome 10 in Lymphomas With t(14;18): A Pathogenetic Role of the Tumor Suppressor Genes PTEN/MMAC1 and MXI1?
Authors: Reiner Siebert, Stefan Gesk, Svetlana Harder, Sebastian Plötz, Peter Matthiesen, Werner Grote, Brigitte Schlegelberger, Burkhard Jandrig, Unn-Hilde Grasmo-Wendler, Siegfried Scherneck, Andreas Rosenwald, German Ott
Journal: Blood (1998)
Getting Closer for High-Resolution Vascular MRI
Authors: Robert J. Lederman, Anthony Z. Faranesh
Journal: JACC. Cardiovascular imaging (2010)

Since the 1980s, investigators have tried to enhance vascular magnetic resonance imaging (MRI) and spectroscopy of deep structures by positioning MRI receiver coils (antennae) inside the body, closer to the tissue of interest ([1,2][1]). Unfortunately, intravascular MRI has been largely
The Authors' response: indications for intestinal transplantation—opinions and facts
Authors: Loris Pironi, Alastair Forbes, André Van Gossum
Journal: Gut (2011)

We thank Abu-Elmagd and Mazariegos1 for their comments and are pleased to have the opportunity to explain our work further.

Our study2 aimed to determine which indications for intestinal transplantation (ITx) were most closely associated with an increased risk of death on home parenteral nutrition (HPN), and whether deaths were due to causes that could be avoided by ITx. The indications for ITx we considered were those described by Medicare, USA, and the American Society of Transplantation; they include objective parameters which allow clear patient identification. Our results confirm that our baseline patient categorisation was appropriate. Ninety-five per cent of patients who were weaned off HPN belonged to the non-candidate group, and 95% of patients who underwent ITx belonged to the candidate group. Survival on HPN was significantly lower in candidates who had HPN failure. Death on HPN was mainly HPN related in candidates, and related to neither HPN …
Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy
Authors: Pankaj Shende, Lifen Xu, Christian Morandi, Laura Pentassuglia, Philippe Heim, Sonia Lebboukh, Corinne Berthonneche, Thierry Pedrazzini, Beat A. Kaufmann, Michael N. Hall, Markus A. Rüegg, Marijke Brink
Journal: Cardiovascular Research (2015)

Mammalian target of rapamycin (mTOR), a central regulator of growth and metabolism, has tissue-specific functions depending on whether it is part of mTOR complex 1 (mTORC1) or mTORC2. We have previously shown that mTORC1 is required for adaptive cardiac hypertrophy and maintenance of function under basal and pressure-overload conditions. In the present study, we aimed to identify functions of mTORC2 in the heart. Using tamoxifen-inducible cardiomyocyte-specific gene deletion, we generated mice deficient for cardiac rapamycin-insensitive companion of mTOR (rictor), an essential and specific component of mTORC2. Under basal conditions, rictor deficiency did not affect cardiac growth and function in young mice and also had no effects in adult mice. However, transverse aortic constriction caused dysfunction in the rictor-deficient hearts, whereas function was maintained in controls after 1 week of pressure overload. Adaptive increases in cardiac weight and cardiomyocyte cross-sectional area, fibrosis, and hypertrophic and metabolic gene expression were not different between the rictor-deficient and control mice. In control mice, maintained function was associated with increased protein levels of rictor, protein kinase C (PKC)βII, and PKCδ, whereas rictor ablation abolished these increases. Rictor deletion also significantly decreased PKCε at baseline and after pressure overload. Our data suggest that reduced PKCε and the inability to increase PKCβII and PKCδ abundance are, in accordance with their known function, responsible for decreased contractile performance of the rictor-deficient hearts. Our study demonstrates that mTORC2 is implicated in maintaining contractile function of the pressure-overloaded male mouse heart.
Abstract 16995: Association Between Anthropometric Measures and Coronary Artery Calcium Score Progression in Multi-Ethnic Population
Authors: Sandip K Zalawadiya, Vikas Veeranna, Sidakpal S Panaich, Naga V Kommuri, Ashutosh Neeraj, Sony Jacob, Luis Afonso
Journal: Circulation (2011)

Abstract: No prior data is available for the comparative analyses on various anthropometric measures and coronary artery calcium score (CACS) progression in healthy low risk multiethnic population. Methods: The MESA (Multi-Ethnic Study of Atherosclerosis) study is a prospective cohort study of 6,814 self-identified White, African-American, Hispanic, or Chinese participants free of clinical cardiovascular disease at baseline. Incident CAC was defined as no CAC at baseline with development of CAC upon subsequent visits. CACS progression was defined as change in CAC volume score upon follow up visit in participants who had detectable CAC at baseline. Anthropometric measures at baseline were compared for their predictive value for incident CAC (analyzed using adjusted logistic regression analysis) and CACS progression (analyzed using adjusted median regression analyses). (See Table 1 for adjustments) Results: See Table 1 Conclusion: Measures of central obesity (especially, waist circumference and waist-hip ratio) have stronger association with both incident CAC and CACS progression among low risk multiethnic population compared to other anthropometric measures.
Anti-PD-1 mAb pre-radiotherapy (RT) loading dose and fractionated RT induce better tumor-specific immunity and tumor shrinkage than sequential administration in an HPV+ head and neck cancer model
Authors: Raghvendra M Srivastava, David A Clump, Robert L Ferris
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Radiotherapy (RT) is a standard therapeutic strategy in the treatment in head and neck cancer (HNC), but many patients still experience recurrence and metastasis. Interestingly, radiotherapy (RT) may also induce immunomodulatory effects. Given the recent, exciting responses seen