tbuckley/cabot-search huggingface dataset:
Decreased number and affinity of rat atrial natriuretic peptide (6-33) binding sites in the subfornical organ of spontaneously hypertensive rats.
Authors: J M Saavedra, A Israel, M Kurihara, E Fuchs
Journal: Circulation Research (1986)

Binding sites for rat atrial natriuretic peptide (6-33) were quantified by incubation of brain sections with (3-[125I]iodotyrosyl28) rat atrial natriuretic peptide (6-33), followed by autoradiography with computerized microdensitometry. Spontaneously hypertensive rats present lower numbers and lower affinity of binding sites than normotensive controls, Wistar-Kyoto rats, in the subfornical organ (binding capacity 61.7 +/- 8.9 and 124.3 +/- 10.7 fmol/mg protein; affinity constant 4.25 +/- 0.55 and 11.10 +/- 1.67 X 10(9) M-1, respectively). In the choroid plexus, hypertensive rats have lower numbers of sites than normotensive rats (binding capacity 72.7 +/- 10.5 and 173.6 +/- 22.8 fmol/mg protein, respectively), but there was no difference in the binding affinity (affinity constant 6.28 +/- 0.82 and 7.60 +/- 2.06 X 10(9) M-1, respectively). Our results suggest that discretely localized brain binding sites for rat atrial natriuretic peptide (6-33) may have a physiological function in genetically hypertensive rats.
High-dose intravenous metoclopramide versus combination high-dose metoclopramide and intravenous dexamethasone in preventing cisplatin-induced nausea and emesis: a single-blind crossover comparison of antiemetic efficacy.
Authors: S B Strum, J E McDermed, D F Liponi
Journal: Journal of Clinical Oncology (1985)

We tested the safety and antiemetic effectiveness of intravenous (IV) dexamethasone (DXM) as an adjunct to high-dose IV metoclopramide (MCP) to prevent nausea and vomiting induced by high-dose cisplatin chemotherapy. Response was determined by using objective and subjective criteria. Thirty patients were randomly assigned to receive MCP alone at a dose of 2 mg/kg IV for three doses or the same dose of MCP plus 20 mg of DXM IV for three doses. Twenty evaluable patients received a second course of cisplatin and were crossed over to the opposite arm. Study results did not show a statistically significant advantage of combination MCP plus DXM over MCP alone using strict objective criteria for antiemetic response. However, patients subjectively preferred MCP plus DXM over MCP alone by nearly a 6:1 ratio, regardless of the randomization sequence. Although the addition of DXM does not appear to objectively improve emetic protection with high-dose MCP, we recommend MCP plus DXM to prevent nausea and vomiting induced by high-dose cisplatin chemotherapy when the use of steroids is not contraindicated, in view of patient preference for the combination.
Abstract 11376: Combination of Pharmacologically and Surface Cooling Induced Hypothermia in a Porcine Model of CPR
Authors: Katherine Tang, Yinlun Weng, Wei Chen, Shijie Sun, Wanchun Tang
Journal: Circulation (2012)

Background:  Mild hypothermia improves the outcomes of CPR. However, currently available techniques for inducing hypothermia are either difficult to achieve target cooling temperature or cumbersome for early application. In this study, we investigated the efficacy of a combination of pharmacological and physical cooling in a porcine model of CPR. Hypothesis: We hypothesized that when the surface cooling combined with a cannabinoid receptor agonist, WIN 55, 212-2, the target cooling temperature could be established in a significantly shorter duration when compared with either surface cooling or pharmacologically induced hypothermia.   Methods:  Ventricular fibrillation was electrically induced and untreated for 7 mins in 28 male swine weighing 35±2kg. Defibrillation was attempted after 5 mins of CPR. The resuscitated animals were randomized in to 4 groups 1) Normothermic, 2) WIN55, 212-2, 3) Surface cooling, 4) WIN55, 212-2 + surface cooling (Combination). The animals were either intravenous infused of WIN 55, 212-2 (1.0mg/kg/h) or the same amount of saline vehicle at 5 mins post-resuscitation. The cooling blanket was utilized for surface cooling.   Results:  The blood temperature was significantly decreased in all hypothermic animals. It was reduced to 34°C ± 0.6 at 90 mins and to 32°C ± 0.7 at 135 mins in animals treated with combination cooling. This was contrasted with WIN55, 212-2 or surface cooling alone groups in which the blood temperature was 36°C ± 0.6 and 35°C ± 1 at 90 and 35.5°C ± 0.8 and 34°C ± 1.3 at 135 mins, respectively (p   Conclusions:  Combination of pharmacological and physical cooling rapidly achieved the target cooling temperature when compared with surface cooling or pharmacologically induced hypothermia alone.
Predictors for Paravalvular Regurgitation After TAVR With the Self-Expanding Prosthesis: Quantitative Measurement of MDCT Analysis
Authors: Sung-Han Yoon, Jung-Min Ahn, Yohei Ohno, Marco Barbanti, Jason Chan, Mao-Shin Lin, Young-Hak Kim, Dong Hyun Yang, Daisuke Sugiyama, Kam-Tim Chan, Sebastiano Immé, Claudia I. Tamburino, Carmelo Sgroi, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Michael Lee, Hsien-Li Kao, Corrado Tamburino, Seung-Jung Park
Journal: JACC. Cardiovascular imaging (2016)
Oral Methylprednisolone Megadose in the Treatment of Recurrent Gliomas and Intracranial Metastases. Preliminary Report
Authors: M. A. Gerosa, C. Licata, A. Nicolato, L. Cristofori, M. Vitale, J. C. Grosslercher, C. Vivenza, A. Bricolo
Journal: Neuro-Oncology (1991)

Between 1987–1990 a series of 43 consecutive patients with inoperable brain tumors, either recurrent malignant gliomas (26 cases) or intracranial metastases (17 cases) have been treated with oral methylprednisolone megadose in our department, for a total amount of 35 evaluable (1 completed cycle) cases: 22 recurrent gliomas and 13 metastases. Eligibility criteria included a Karnofsky score over 40, age over 18, no further indications for surgery or radiation therapy. Pre-treatment grading was based upon a neurological, radiological (CT scan) and performance score. Oral methylprednisolone megadose schedule ( 1 cycle: 300 mg/sq.m. p.o./alt. days q 10–12 wks) was immediately withdrawn if non-tolerated or suspended after 1 cycle if ineffective. Each single cycle was routinely followed by a day-hospital re-grading with laboratory controls. Even though a long-term follow-up is still under evaluation, preliminary results indicate an improved quality of life, with no steroid-dependency and a dramatic decrease in gastro-enteric side-effects. Actuarial survival rates show a slight increase, statistically non-significant.
Frontline Nilotinib Results In Superior Rates Of Molecular Response Versus Imatinib In Chinese Patients With Chronic Myeloid Leukemia In Chronic Phase (CML-CP): ENESTchina 12-Month Primary Analysis
Authors: Xiaojun Huang, Jianxiang Wang, Michele Baccarani, Svetlana Jevtic, Christine-Elke Ortmann, Ye Yuan, Hans D. Menssen, Giuseppe Saglio, Zhi-Xiang Shen
Journal: Blood (2013)
Why We Need a Transdiagnostic Staging Approach to Emerging Psychopathology, Early Diagnosis, and Treatment
Authors: Patrick McGorry, Barnaby Nelson
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Systemic therapy (ST) in cancer patients ≥ 80 years of age: A Manitoba population-based assessment
Authors: J. R. Gingerich, D. Turner, S. Xiaoyun, P. Czaykowski
Journal: Journal of Clinical Oncology (2006)

6090 Background: Little is known about the cancer characteristics, treatment options and outcomes in the oldest subset of the elderly, those ≥ 80, who develop cancer. Methods: We employed a population-based, cross-sectional design utilizing the provincial cancer registry and administrative data augmented by clinic-specific retrospective chart review to study the demographics, treatment and outcomes of patients ≥ 80 diagnosed with cancer in the years 2002–2003 in Manitoba, Canada. We assessed treatment patterns for various subgroups (analyzed using chi-square and Fisher’s exact tests to determine association, as appropriate) and associated survival. Results: Our cohort included 2,194 patients. This represented 20.8% of all incident cases. The median age was 84 (range: 80–102), with a slight preponderance of females (53%). As expected, prostate, lung, and colorectal cancers were most common for males with breast, lung, and colorectal cancer being most common for females. Only 241 (10.9%) of the cohort were referred to the central cancer centre for consideration of ST which was less than the overall referral rate of 33%. Of those referred, 57% did not receive ST, 20% received palliative ST, and 23% received adjuvant/curative ST. The two year survival rates were statistically significant by treatment categories (not referred = 39%, referred but who did not receive ST = 39%, palliative ST = 27%, and adjuvant/curative ST = 76%,) (p&lt;0.0001). The Charlson score for those patients referred who received ST was lower than those who did not receive ST (p&lt;0.0001) Conclusions: Our data indicate that in patients ≥ 80 years of age with cancer, few are referred to the central cancer clinic for ST. Of those referred, patients who receive adjuvant/curative intent ST live longer then those not receiving ST. Lower Charlson scores (indicative of fewer comorbidities and better general health) were found more often in patients receiving ST. No significant financial relationships to disclose.
Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression
Authors: Mickael Audrain, Romain Fol, Patrick Dutar, Brigitte Potier, Jean-Marie Billard, Julien Flament, Sandro Alves, Marie-Anne Burlot, Gaelle Dufayet-Chaffaud, Alexis-Pierre Bemelmans, Julien Valette, Philippe Hantraye, Nicole Déglon, Nathalie Cartier, Jérome Braudeau
Journal: Molecular Neurodegeneration (2016)

Alzheimer’s disease (AD) is the most frequent form of dementia in the elderly and no effective treatment is currently available. The mechanisms triggering AD onset and progression are still imperfectly dissected. We aimed at deciphering the modifications occurring in vivo during the very early stages of AD, before the development of amyloid deposits, neurofibrillary tangles, neuronal death and inflammation. Most current AD models based on Amyloid Precursor Protein (APP) overproduction beginning from in utero, to rapidly reproduce the histological and behavioral features of the disease within a few months, are not appropriate to study the early steps of AD development. As a means to mimic in vivo amyloid APP processing closer to the human situation in AD, we used an adeno-associated virus (AAV)-based transfer of human mutant APP and Presenilin 1 (PS1) genes to the hippocampi of two-month-old C57Bl/6 J mice to express human APP, without significant overexpression and to specifically induce its amyloid processing. The human APP, βCTF and Aβ42/40 ratio were similar to those in hippocampal tissues from AD patients. Three months after injection the murine Tau protein was hyperphosphorylated and rapid synaptic failure occurred characterized by decreased levels of both PSD-95 and metabolites related to neuromodulation, on proton magnetic resonance spectroscopy (1H-MRS). Astrocytic GLT-1 transporter levels were lower and the tonic glutamatergic current was stronger on electrophysiological recordings of CA1 hippocampal region, revealing the overstimulation of extrasynaptic N-methyl D-aspartate receptor (NMDAR) which precedes the loss of long-term potentiation (LTP). These modifications were associated with early behavioral impairments in the Open-field, Y-maze and Morris Mater Maze tasks. Altogether, this demonstrates that an AD-like APP processing, yielding to levels of APP, βCTF and Aβ42/Aβ40 ratio similar to those observed in AD patients, are sufficient to rapidly trigger early steps of the amyloidogenic and Tau pathways in vivo. With this strategy, we identified a sequence of early events likely to account for disease onset and described a model that may facilitate efforts to decipher the factors triggering AD and to evaluate early neuroprotective strategies.
Surveillance and Outbreak Response Management System (SORMAS) to support the control of the Ebola virus disease outbreak in West Africa
Authors: C Fähnrich, K Denecke, O O Adeoye, J Benzler, H Claus, G Kirchner, S Mall, R Richter, M P Schapranow, NG Schwarz, D Tom-Aba, M Uflacker, G Poggensee, G Krause
Journal: Eurosurveillance (2015)

Binary file ES_Abstracts_Final_ECDC.txt matches
A Randomized Phase III Study of Docetaxel Plus Cisplatin Versus Pemetrexed Plus Cisplatin in First Line Non-Squamous Non-Small Cell Lung Cancer (Nsq-Nsclc)
Authors: Y. Kim, I. Oh, K. Kim, T. Jang, Y.D. Choi, Y.S. Kim, K. Lee, K. Shin, C.Y. Jung, S. Yang, S. Jang, J. Ryu, S.S. Yoo, S. Yong, K. Lee, K. In, M.K. Lee
Journal: Annals of Oncology (2014)
Retrospective Analysis of Long-Term Outcomes After Combat Injury
Authors: Ian J. Stewart, Jonathan A. Sosnov, Jeffrey T. Howard, Jean A. Orman, Raymond Fang, Benjamin D. Morrow, David H. Zonies, Mary Bollinger, Caroline Tuman, Brett A. Freedman, Kevin K. Chung
Journal: Circulation (2015)

Background— During the conflicts in Iraq and Afghanistan, 52 087 service members have been wounded in combat. The long-term sequelae of these injuries have not been carefully examined. We sought to determine the relation between markers of injury severity and the subsequent development of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease. Methods and Results— Retrospective cohort study of critically injured US military personnel wounded in Iraq or Afghanistan from February 1, 2002 to February 1, 2011. Patients were then followed until January 18, 2013. Chronic disease outcomes were assessed by International Classification of Diseases, 9th edition codes and causes of death were confirmed by autopsy. From 6011 admissions, records were excluded because of missing data or if they were for an individual’s second admission. Patients with a disease diagnosis of interest before the injury date were also excluded, yielding a cohort of 3846 subjects for analysis. After adjustment for other factors, each 5-point increment in the injury severity score was associated with a 6%, 13%, 13%, and 15% increase in incidence rates of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease, respectively. Acute kidney injury was associated with a 66% increase in rates of hypertension and nearly 5-fold increase in rates of chronic kidney disease. Conclusions— In Iraq and Afghanistan veterans, the severity of combat injury was associated with the subsequent development of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease.
Evaluating Appropriate Blood Transfusion in Cancer Surgery
Authors: David D. Odell, Karl Y. Bilimoria
Journal: JAMA Surgery (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Low cost mesh for hernia repair is as good as commercial mesh, trial finds
Authors: Susan Mayor
Journal: BMJ (2016)

Men undergoing hernia repair using a low cost mesh have a similar rate of hernia recurrence and postoperative complications as those treated with a commercial mesh, shows a randomised trial carried out in Uganda, where commercial meshes are generally unaffordable.

The trial randomly allocated 302 adult men with primary, unilateral, reducible groin hernias to undergo surgical hernia repair using either a low cost mesh or a commercial synthetic mesh.1

Commercial meshes are too expensive for most patients in low and …
Tamoxifen rechallenge: response to tamoxifen following relapse after adjuvant chemohormonal therapy for breast cancer.
Authors: H B Muss, L R Smith, M R Cooper
Journal: Journal of Clinical Oncology (1987)

Two-hundred seventy-three node-positive primary breast cancer patients with positive estrogen or progesterone receptors were placed on a short-term chemohormonal adjuvant program that included tamoxifen. At present, 64 have relapsed, 19 of whom have been rechallenged with tamoxifen after disease-free intervals (DFI) ranging from 0.4 to 4.4 years. Most patients had only one site of disease recurrence. Two patients have achieved complete remission (CR) and three partial remission (PR) for a CR and PR rate of 26% (95% confidence interval for CR and PR is 9% to 51%). Duration of response has ranged from 3 to 17+ months. Patients who receive short-term adjuvant therapy with tamoxifen and who relapse may respond to tamoxifen rechallenge. In this series, the response rate to tamoxifen rechallenge was similar to the response rate for patients unselected for estrogen receptor status receiving first-line endocrine therapy for breast cancer relapse.
Global warming
Authors: Jonathan A Patz
Journal: BMJ (2004)

The ventral striatum is involved in motivated behavior. Akin to the dorsal striatum, the ventral striatum contains two parallel pathways: the striatomesencephalic pathway consisting of dopamine receptor Type 1-expressing medium spiny neurons (D1-MSNs) and the striatopallidal pathway consisting of D2-MSNs. These two genetically identified pathways are thought to encode opposing functions in motivated behavior. It has also been reported that D1/D2 genetic selectivity is not attributed to the anatomical discrimination of two pathways. We wanted to determine whether D1- and D2-MSNs in the ventral striatum functioned in an opposing manner as previous observations claimed, and whether D1/D2 selectivity corresponded to a functional segregation in motivated behavior of mice. To address this question, we focused on the lateral portion of ventral striatum as a region implicated in food-incentive, goal-directed behavior, and recorded D1 or D2-MSN activity by using a gene-encoded ratiometric Ca<sup>2+</sup> indicator and by constructing a fiberphotometry system, and manipulated their activities via optogenetic inhibition during ongoing behaviors. We observed concurrent event-related compound Ca<sup>2+</sup> elevations in ventrolateral D1- and D2-MSNs, especially at trial start cue-related and first lever press-related times. D1 or D2 selective optogenetic inhibition just after the trial start cue resulted in a reduction of goal-directed behavior, indicating a shared coding of motivated behavior by both populations at this time. Only D1-selective inhibition just after the first lever press resulted in the reduction of behavior, indicating D1-MSN-specific coding at that specific time. Our data did not support opposing encoding by both populations in food-incentive, goal-directed behavior. <b>SIGNIFICANCE STATEMENT</b> An opposing role of dopamine receptor Type 1 or Type 2-expressing medium spiny neurons (D1-MSNs or D2-MSNs) on striatum-mediated behaviors has been widely accepted. However, this idea has been questioned by recent reports. In the present study, we measured concurrent Ca<sup>2+</sup> activity patterns of D1- and D2-MSNs in the ventrolateral striatum during food-incentive, goal-directed behavior in mice. According to Ca<sup>2+</sup> activity patterns, we conducted timing-specific optogenetic inhibition of each type of MSN. We demonstrated that both D1- and D2-MSNs in the ventrolateral striatum commonly and positively encoded action initiation, whereas only D1-MSNs positively encoded sustained motivated behavior. These findings led us to reconsider the prevailing notion of a functional segregation of MSN activity in the ventral striatum.
Lung 18F-FDG uptake correlates with lung function alteration in patients with IPF
Authors: Aurélien Justet, Astrid Laurent-Bellue, Marie-Pierre Debray, Raphaël Borie, Rachida Lebtahi, Bruno Crestani
Journal: European Respiratory Journal (2014)

Purpose:

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a very poor prognosis. Non-invasive markers of prognosis are lacking. We assessed lung 18F-FDG uptake in patients with IPF.

Methods:

The maximal (SUVmax) and the mean (SUVmean) lung 18F- FDG uptake was measured in each lung, as a standardized uptake value, in 28 consecutive patients with IPF, diagnosed according to the 2011 ATS/ERS/JRS/ALAT guidelines, and compared with normal lung from 15 control patients with extra-thoracic neoplasm. Lung function tests, bronchoalveolar lavage and HRCT results were obtained within one month. HRCT fibrosis and ground glass were scored according to Kazerooni et al (Kazerooni et al, American Journal of Roentgenology .1997 :169 ; 977-933)

Results:

An increased lung uptake of 18F-FDG was measured in IPF patients either for SUV mean (1.01±0.06 vs 0.50±0.02, p<0.00001, unpaired t-test) or SUV max (2.83±0,12 vs 1.83±0.11,p<0.0001). FVC (%) and DLCO (%) negatively correlated with SUV mean (respectively r=-0.48 [-0,73;-0,12] p=0,01; r=-0.63 [-0,82;-0,31], p=0,0008, Pearson test) and SUV max (respectively, r=-0,51, [-0,75;-0,15] p=0,008; r= -0,59 [-0,79;-0,25] p=0,002). Left lower lobe fibrosis score correlated with SUV mean (r= 0,58, [0,23;0,80],p=0,002) but right lower lobe did not (r=0,21, [-0,17;0,54],p=0,27) . Pulmonary 18F- FDG uptake did not correlate with BAL cytology, lung function decline or survival.

Conclusion

Our results indicate that lung 18F-FDG uptake correlates with lung function alteration and lung fibrosis score but does not predict outcome in patients with IPF.