tbuckley/cabot-search huggingface dataset:
Orthopnoea and arm weakness
Authors: H K Chen, D Jardine, L Beckert
Journal: Thorax (2009)

<h3>Introduction</h3> Emergency calls to ambulance services are frequent for older people who have fallen, but ambulance crews often leave patients at the scene without ongoing care. Evidence shows that when left at home with no further support older people often experience subsequent falls which result in injury and emergency-department attendances. SAFER 2 is an evaluation of a new clinical protocol which allows paramedics to assess and refer older people who have fallen, and do not need hospital care, to community-based falls services. In this protocol paper, we report methods and progress during trial implementation. SAFER 2 is recruiting patients through three ambulance services. A successful trial will provide robust evidence about the value of this new model of care, and enable ambulance services to use resources efficiently. <h3>Design</h3> Pragmatic cluster randomised trial. <h3>Methods and analysis</h3> We randomly allocated 25 participating ambulance stations (clusters) in three services to intervention or control group. Intervention paramedics received training and clinical protocols for assessing and referring older people who have fallen to community-based falls services when appropriate, while control paramedics deliver care as usual. Patients are eligible for the trial if they are aged 65 or over; resident in a participating falls service catchment area; and attended by a trial paramedic following an emergency call coded as a fall without priority symptoms. The principal outcome is the rate of further emergency contacts (or death), for any cause and for falls. Secondary outcomes include further falls, health-related quality of life, ‘fear of falling’, patient satisfaction reported by participants through postal questionnaires at 1 and 6 months, and quality and pathways of care at the index incident. We shall compare National Health Service (NHS) and patient/carer costs between intervention and control groups and estimate quality-adjusted life years (QALYs) gained from the intervention and thus incremental cost per QALY. We shall estimate wider system effects on key-performance indicators. We shall interview 60 intervention patients, and conduct focus groups with contributing NHS staff to explore their experiences of the assessment and referral service. We shall analyse quantitative trial data by ‘treatment allocated’; and qualitative data using content analysis. <h3>Ethics and dissemination</h3> The Research Ethics Committee for Wales gave ethical approval and each participating centre gave NHS Research and Development approval. We shall disseminate study findings through peer-reviewed publications and conference presentations. <b>Trial Registration:</b> ISRCTN 60481756
1′-Acetoxychavicol Acetate Is a Novel Nuclear Factor κB Inhibitor with Significant Activity against Multiple Myeloma <i>In vitro</i> and <i>In vivo</i>
Authors: Keisuke Ito, Tomonori Nakazato, Ming Ji Xian, Taketo Yamada, Nobumichi Hozumi, Akira Murakami, Hajime Ohigashi, Yasuo Ikeda, Masahiro Kizaki
Journal: Cancer Research (2005)

Abstract 1′-Acetoxychavicol acetate (ACA) is a component of a traditional Asian condiment obtained from the rhizomes of the commonly used ethno-medicinal plant Languas galanga. Here, we show for the first time that ACA dramatically inhibits the cellular growth of human myeloma cells via the inhibition of nuclear factor κB (NF-κB) activity. In myeloma cells, cultivation with ACA induced G0-G1 phase cell cycle arrest, followed by apoptosis. Treatment with ACA induced caspase 3, 9, and 8 activities, suggesting that ACA-induced apoptosis in myeloma cells mediates both mitochondrial- and Fas-dependent pathways. Furthermore, we showed that ACA significantly inhibits the serine phosphorylation and degradation of IκBα. ACA rapidly decreased the nuclear expression of NF-κB, but increased the accumulation of cytosol NF-κB in RPMI8226 cells, indicating that ACA inhibits the translocation of NF-κB from the cytosol to the nucleus. To evaluate the effects of ACA in vivo, RPMI8226-transplanted NOD/SCID mice were treated with ACA. Tumor weight significantly decreased in the ACA-treated mice compared with the control mice. In conclusion, ACA has an inhibitory effect on NF-κB, and induces the apoptosis of myeloma cells in vitro and in vivo. ACA, therefore, provides a new biologically based therapy for the treatment of multiple myeloma patients as a novel NF-κB inhibitor.
Asbestos and Mesothelioma
Authors: Melvin C. Godwin
Journal: JAMA (1968)

To the Editor:—  A recent letter ( 203 :1142, 1968) states that the problem of mesothelioma formation is not one that involves the whole asbestos industry, but only users of crocidolite, and this mineral represents a relatively small proportion of total consumption. It has been shown 1 that mesothelioma occurs in workers exposed to chrysotile extensively mined in Canada. We have seen mesothelioma formation in workers weaving brake lining, which is made from chrysotile. Exposure was three years as a young adult, and death was caused by a peritoneal mesothelioma at 43. Another case was a 50-year-old man who worked in a Canadian asbestos mine five years and who died of pleural mesothelioma 15 years after the first exposure. Analysis of tissue by x-ray diffraction indicated that chrysotile was the only form of asbestos present. Wagner and Skidmore 2 induced mesotheliomas in the pleura of rats that inhaled chrysotile, crocidolite, amosite,
Palmoplantar keratoderma associated with congenital heart disease
Authors: None Hoeger, None Yates, None Harper
Journal: British Journal of Dermatology (1998)

We report the case of a 14‐month‐old boy suffering from total anomalous pulmonary venous connection (TAPVC) associated with congenital diffuse palmoplantar keratoderma (PPK). An association between TAPVC and PPK has not been described previously, but PPK has been reported in association with a variety of cardiac abnormalities. Given the low frequency of both conditions, a genetic link seems likely. It is therefore advisable for dermatologists to check for heart abnormalities in children with congenital PPK.
Maintaining the dose intensity of ICE chemotherapy with a thrombopoietic agent, PEG-rHuMGDF, may confer a survival advantage in relapsed and refractory aggressive non-Hodgkin lymphoma
Authors: C.H. Moskowitz, P.A. Hamlin, J. Gabrilove, J.R. Bertino, C.S. Portlock, D.J. Straus, A.N. Gencarelli, S.D. Nimer, A.D. Zelenetz
Journal: Annals of Oncology (2007)
Percutaneous Coronary Intervention Outcomes in Patients With Stable Obstructive Coronary Artery Disease and Myocardial Ischemia
Authors: Kathleen Stergiopoulos, William E. Boden, Pamela Hartigan, Sven Möbius-Winkler, Rainer Hambrecht, Whady Hueb, Regina M. Hardison, J. Dawn Abbott, David L. Brown
Journal: JAMA Internal Medicine (2013)

Myocardial ischemia in patients with stable coronary artery disease (CAD) has been repeatedly associated with impaired survival. However, it is unclear if revascularization with percutaneous coronary intervention (PCI) to relieve ischemia improves outcomes compared with medical therapy (MT). The objective of this study was to compare the effect of PCI and MT with MT alone exclusively in patients with stable CAD and objectively documented myocardial ischemia on clinical outcomes. MEDLINE, Cochrane, and PubMed databases from 1970 to November 2012. Unpublished data were obtained from investigators. Randomized clinical trials of PCI and MT vs MT alone for stable coronary artery disease in which stents and statins were used in more than 50% of patients. For studies in which myocardial ischemia diagnosed by stress testing or fractional flow reserve was required for enrollment, descriptive and quantitative data were extracted from the published report. For studies in which myocardial ischemia was not a requirement for enrollment, authors provided data for only those patients with ischemia determined by stress testing prior to randomization. The outcomes analyzed included death from any cause, nonfatal myocardial infarction (MI), unplanned revascularization, and angina. Summary odds ratios (ORs) were obtained using a random-effects model. Heterogeneity was assessed using the Q statistic and I2. In 5 trials enrolling 5286 patients, myocardial ischemia was diagnosed in 4064 patients by exercise stress testing, nuclear or echocardiographic stress imaging, or fractional flow reserve. Follow-up ranged from 231 days to 5 years (median, 5 years). The respective event rates for PCI with MT vs MT alone for death were 6.5% and 7.3% (OR, 0.90 [95% CI, 0.71-1.16); for nonfatal MI, 9.2% and 7.6% (OR, 1.24 [95% CI, 0.99-1.56]); for unplanned revascularization, 18.3% and 28.4% (OR, 0.64 [95% CI, 0.35-1.17); and for angina, 20.3% and 23.3% (OR, 0.91 [95% CI, 0.57-1.44]). In patients with stable CAD and objectively documented myocardial ischemia, PCI with MT was not associated with a reduction in death, nonfatal MI, unplanned revascularization, or angina compared with MT alone.
LUPUS ERYTHEMATOSUS: TREATMENT WITH PENICILLIN
Authors: D. STONE
Journal: British Journal of Dermatology (1946)

Journal Article LUPUS ERYTHEMATOSUS: TREATMENT WITH PENICILLIN Get access D. STONE, R. A. M. C Capt. D. STONE, R. A. M. C Capt. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 58, Issue 5-6, 1 May 1946, Pages 122–123, https://doi.org/10.1111/j.1365-2133.1946.tb16285.x Published: 01 May 1946
Quality of Life Supersedes the Classic Prognosticators for Long-Term Survival in Locally Advanced Non–Small-Cell Lung Cancer: An Analysis of RTOG 9801
Authors: Benjamin Movsas, Jennifer Moughan, Linda Sarna, Corey Langer, Maria Werner-Wasik, Nicos Nicolaou, Ritsuko Komaki, Mitchell Machtay, Todd Wasserman, Deborah Watkins Bruner
Journal: Journal of Clinical Oncology (2009)

To determine the added value of quality of life (QOL) as a prognostic factor for overall survival (OS) in patients with locally advanced non-small-cell lung cancer (NSCLC) treated on Radiation Therapy Oncology Group RTOG-9801.
SENSORY HABITUATION AND DISCRIMINATION IN THE HUMAN NEONATE
Authors: WAGNER H. BRIDGER
Journal: American Journal of Psychiatry (1961)

In summary, in the process of exploring the neonates' behavioral and autonomic repertoire for the purpose of devising techniques that would enable us to measure temperamental differences, we have come across two phenomena that we would like to emphasize. First we described the neonate's ability to habituate his responses to sensory stimuli and pointed out its possible relations to the neurophysiological structure subserving arousal, inhibition and attention; second we demonstrated that neonates have the capacity for sensory discrimination but noted that this primitive discrimination and habituation need not be dependent on the functioning of cerebral cortex and does not appear to be identical with the same phenomena in the mature organism.
International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology
Authors: Ravindra L Mehta, Jorge Cerdá, Emmanuel A Burdmann, Marcello Tonelli, Guillermo García-García, Vivekanand Jha, Paweena Susantitaphong, Michael Rocco, Raymond Vanholder, Mehmet Sukru Sever, Dinna Cruz, Bertrand Jaber, Norbert H Lameire, Raúl Lombardi, Andrew Lewington, John Feehally, Fredric Finkelstein, Nathan Levin, Neesh Pannu, Bernadette Thomas, Eliah Aronoff-Spencer, Giuseppe Remuzzi
Journal: The Lancet (2015)
Doxorubicin loaded superparamagnetic PLGA-iron oxide multifunctional microbubbles for dual-mode US/MR imaging and therapy of metastasis in lymph nodes
Authors: Chengcheng Niu, Zhigang Wang, Guangming Lu, Tianyi M. Krupka, Yang Sun, Yufang You, Weixiang Song, Haitao Ran, Pan Li, Yuanyi Zheng
Journal: Biomaterials (2012)
Cry baby cry, make your mother buy? Evolution of tears, smiles, and reciprocity potential
Authors: Minna Lyons
Journal: Behavioral and Brain Sciences (2009)

Abstract In this commentary, the idea of reciprocity potential indicators is tied in with ultimate accounts on sex differences in social sensitivity. It is proposed that, rather than crying, smiling is a more likely cooperative signal. The possibility of coevolution and polymorphism in perceptual and signalling systems are also discussed briefly, with a reference to Theory of Mind and Machiavellianism.
Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules
Authors: Sofia Johansson, Maria Johansson, Eleftheria Rosmaraki, Gustaf Vahlne, Ramit Mehr, Mali Salmon-Divon, François Lemonnier, Klas Kärre, Petter Höglund
Journal: The Journal of Experimental Medicine (2005)

The ability of murine NK cells to reject cells lacking self MHC class I expression results from an in vivo education process. To study the impact of individual MHC class I alleles on this process, we generated mice expressing single MHC class I alleles (Kb, Db, Dd, or Ld) or combinations of two or more alleles. All single MHC class I mice rejected MHC class I–deficient cells in an NK cell–dependent way. Expression of Kb or Dd conveyed strong rejection of MHC class I–deficient cells, whereas the expression of Db or Ld resulted in weaker responses. The educating impact of weak ligands (Db and Ld) was further attenuated by the introduction of additional MHC class I alleles, whereas strong ligands (Kb and Dd) maintained their educating impact under such conditions. An analysis of activating and inhibitory receptors in single MHC class I mice suggested that the educating impact of a given MHC class I molecule was controlled both by the number of NK cells affected and by the strength of each MHC class I–Ly49 receptor interaction, indicating that NK cell education may be regulated by a combination of qualitative and quantitative events.
2008 Homer W. Smith Award
Authors: Peter C. Harris
Journal: Journal of the American Society of Nephrology (2009)

Polycystic kidney diseases (PKD) are a group of inherited disorders characterized by morbidity-associated development of renal cysts. Three forms of PKD are described here: The common, late onset, autosomal dominant PKD (ADPKD); the mainly infantile, autosomal recessive PKD (ARPKD); and the lethal, syndromic, Meckel syndrome that also includes central nervous system and digital defects. Positional cloning approaches based on genetic linkage have identified the disease genes in these disorders. Completion of the Human Genome Project, cases with atypical mutation, and animal models have greatly aided gene identification, and characterization of the disease genes has allowed establishment of molecular diagnostics. Genetic and allelic heterogeneity, plus genetic modification, underlie the significant phenotypic variability in each disorder. Positional cloning identified novel disease-associated protein families: The polycystins (ADPKD); fibrocystins (ARPKD); and meckelin. A common feature of pathogenesis in each disorder seems to be the primary cilia, implicating detection of fluid flow and the developmental process of planar cell polarity. Identifying the primary defect has contributed to our understanding of defective cellular processes and highlights potential therapeutic targets. A number of agents are now in Phase 3 trials, and many others show promise preclinically, providing hope of effective treatments for ADPKD in the foreseeable future.
RENAL TUBULAR SECRETION AND REABSORPTION OF ORGANIC BASES IN THE DOG*
Authors: Jorge Torretti, I. M. Weiner, Gilbert H. Mudge
Journal: Journal of Clinical Investigation (1962)

1 Bidirectional transport poses a difficult semantic problem.In this paper, secretion and reabsorption are defined in terms of direction of transport without implication as to underlying mechanism, secretion being move- -ment from peritubular fluid into the tubule, and reab- sorption being in the opposite direction.When referring to a given segment of the nephron, one may consider .eithernet segmental secretion or net segmental reabsorp- tion, such terms being defined as a function of the quan-
Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective
Authors: Anne W.M. Lee, Brigette B.Y. Ma, Wai Tong Ng, Anthony T.C. Chan
Journal: Journal of Clinical Oncology (2015)

Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern China, and patient prognosis has improved significantly over the past three decades because of advances in disease management, diagnostic imaging, radiotherapy technology, and broader application of systemic therapy. Despite the excellent local control with modern radiotherapy, distant failure remains a key challenge. Advances in molecular technology have helped to decipher the molecular pathogenesis of nasopharyngeal carcinoma as well as its etiologic association with the Epstein-Barr virus. This in turn has led to the discovery of novel biomarkers and drug targets, rendering this cancer site a current focus for new drug development. This article reviews and appraises the key literature on the current management of nasopharyngeal carcinoma and future directions in clinical research.
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene.
Authors: M Adams, C Matthews, T N Collingwood, Y Tone, P Beck-Peccoz, K K Chatterjee
Journal: Journal of Clinical Investigation (1994)

Resistance to thyroid hormone (RTH), with elevated serum free thyroid hormones and nonsuppressed thyrotropin levels, is either relatively asymptomatic, suggesting a generalized disorder (GRTH) or associated with thyrotoxic features, indicating possible selective pituitary resistance (PRTH). 20 GRTH and 9 PRTH cases, sporadic or dominantly inherited, were analyzed. Affected individuals were heterozygous for single nucleotide substitutions in the thyroid hormone receptor beta gene, except for a single case of a seven nucleotide insertion. With one exception, the corresponding 13 novel and 7 known codon changes localized to and extended the boundaries of two mutation clusters in the hormone-binding domain of the receptor. 15 kindreds shared 6 different mutations, and haplotype analyses of the mutant allele showed that they occurred independently. The majority (14 out of 19) of the recurrent but a minority (1 out of 10) of unique mutations were transitions of CpG dinucleotides. Mutant receptor binding to ligand was moderately or severely impaired and did not correlate with the magnitude of thyroid dysfunction. There was no association between clinical features and the nature or location of a receptor mutation. These observations suggest that GRTH and PRTH are phenotypic variants of the same genetic disorder, whose clinical expression may be modulated by other non-mutation-related factors.
Tissue Inhibitors of Metalloproteinase 2 Inhibits Endothelial Cell Migration through Increased Expression of RECK
Authors: Junseo Oh, Dong-Wan Seo, Tere Diaz, Beiyang Wei, Yvona Ward, Jill M. Ray, Yoko Morioka, Shuliang Shi, Hitoshi Kitayama, Chiaki Takahashi, Makoto Noda, William G. Stetler-Stevenson
Journal: Cancer Research (2004)

Abstract The antiangiogenic function of the tissue inhibitors of metalloproteinases (TIMPs) has been attributed to their matrix metalloproteinase inhibitory activity. Here we demonstrate that TIMP-1 but not Ala+TIMP-1 inhibits both basal and vascular endothelial growth factor (VEGF)-stimulated migration of human microvascular endothelial cells (hMVECs), suggesting that this effect is dependent on direct inhibition of matrix metalloproteinase (MMP) activity. In contrast, TIMP-2 and mutant Ala+TIMP-2, which is devoid of MMP inhibitory activity, block hMVEC migration in response to VEGF-A stimulation. TIMP-2 and Ala+TIMP-2 also suppress basal hMVEC migration via a time-dependent mechanism mediated by enhanced expression of RECK, a membrane-anchored MMP inhibitor, which, in turn, inhibits cell migration. TIMP-2 treatment of hMVECs increases the association of Crk with C3G, resulting in enhanced Rap1 activation. hMVECs stably expressing Rap1 have increased RECK expression and display reduced cell migration compared with those expressing inactive Rap1(38N). RECK-null murine embryo fibroblasts fail to demonstrate TIMP-2–mediated decrease in cell migration despite activation of Rap1. TIMP-2–induced RECK decreases cell-associated MMP activity. Anti-RECK antibody increases MMP activity and reverses the TIMP-2–mediated reduction in cell migration. The effects of TIMP-2 on RECK expression and cell migration were confirmed in A2058 melanoma cells. These results suggest that TIMP-2 can inhibit cell migration via several distinct mechanisms. First, TIMP-2 can inhibit cell migration after VEGF stimulation by direct inhibition of MMP activity induced in response to VEGF stimulation. Secondly, TIMP-2 can disrupt VEGF signaling required for initiation of hMVEC migration. Third, TIMP-2 can enhance expression of RECK via Rap1 signaling resulting in an indirect, time-dependent inhibition of endothelial cell migration.
Sarcoidosis severity and socioeconomic status
Authors: D.L. Rabin, M.S.A. Richardson, S.R. Stein, H. Yeager
Journal: European Respiratory Journal (2001)

Several chronic diseases are more severe in persons who are Black, of low socioeconomic status (SES), and underinsured. The authors ask if this is true for sarcoidosis. Associations among sarcoidosis disease severity, SES, insurance coverage, and functional limitations were analysed. Back and White sarcoidosis patients (n=110) of a municipal and university hospital sarcoidosis registry were interviewed by telephone. Data on disease severity were abstracted from patient charts. Most patients reported good or excellent health by demographic characteristics. Low SES and no or public insurance were associated with worse health status and more severe dyspnoea. More advanced radiographic stage was associated with lower income, and forced vital capacity impairment with less education. Physical and social activity limitations due to physical and emotional disability were related to no or public insurance and lower income, but not education. Sarcoidosis severity is associated with socioeconomic status and insurance indicators; no or public insurance and low income are associated with functional limitations. Sarcoidosis-associated limitations are substantial, emphasizing the social significance of sarcoidosis. Lack of private insurance may inhibit the use of medical care, contributing to disease severity and impairment.
Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial
Authors: Diane M Harper, Eduardo L Franco, Cosette Wheeler, Daron G Ferris, David Jenkins, Anne Schuind, Toufik Zahaf, Bruce Innis, Paulo Naud, Newton S De Carvalho, Cecilia M Roteli-Martins, Julio Teixeira, Mark M Blatter, Abner P Korn, Wim Quint, Gary Dubin
Journal: The Lancet (2004)
HUMAN T-LYMPHOTROPIC VIRUS TYPE III (HTLV-III) INFECTION IN SERONEGATIVE HAEMOPHILIACS AFTER TRANSFUSION OF FACTOR VIII
Authors: C.A. Ludlam, C.M. Steel, R. Cheingsong-Popov, D.B.L. Mcclelland, J. Tucker, R.S. Tedder, R.A. Weiss, I. Philp, R.J. Prescott
Journal: The Lancet (1985)