tbuckley/cabot-search huggingface dataset:
Clindamycin and rifampicin combination therapy for hidradenitis suppurativa
Authors: C.O. Mendonça, C.E.M. Griffiths
Journal: British Journal of Dermatology (2006)

Background Hidradenitis suppurativa (HS) is a chronic inflammatory condition affecting apocrine gland-bearing areas of the skin. There is currently no satisfactory treatment. Objectives To assess the efficacy of a 10-week course of combination clindamycin 300 mg twice daily and rifampicin 300 mg twice daily in the treatment of HS. Methods Patients who had received combination therapy with clindamycin and rifampicin for HS at one U.K. Dermatology Centre between the years 1998 and 2003 were identified from pharmacy records. Their records were analysed retrospectively. Results Fourteen patients with HS had received treatment with combination therapy. Eight of these patients achieved remission and a further two achieved remission when minocycline was substituted for clindamycin. Four patients were unable to tolerate therapy. Conclusions This small retrospective study indicates that combination therapy with clindamycin and rifampicin may be effective for HS. However, there is a need for a placebo-controlled trial.
Widespread pruritic plaques in a patient with subacute cutaneous lupus erythematosus and hypocomplementemia: Response to dapsone therapy
Authors: Kiyohiro Tsutsui, Toshio Imai, Naoto Hatta, Hideaki Sakai, Minoru Takata, Kazuhiko Takehara
Journal: Journal of the American Academy of Dermatology (1996)
Adoptive T cell therapy for cancer in the clinic
Authors: Carl H. June
Journal: Journal of Clinical Investigation (2007)

The transfusion of lymphocytes, referred to as adoptive T cell therapy, is being tested for the treatment of cancer and chronic infections. Adoptive T cell therapy has the potential to enhance antitumor immunity, augment vaccine efficacy, and limit graft-versus-host disease. This form of personalized medicine is now in various early- and late-stage clinical trials. These trials are currently testing strategies to infuse tumor-infiltrating lymphocytes, CTLs, Th cells, and Tregs. Improved molecular biology techniques have also increased enthusiasm and feasibility for testing genetically engineered T cells. The current status of the field and prospects for clinical translation are reviewed herein.
A Review of Methods for the Exact Registration of Some Coarse Changes in the Brains of the Insane
Authors: F. St. J. Bullen
Journal: BMJ (1889)

others, however, it had been of use.It improved the appetite often when the mental symiptoms were not much ameliorated.MIassage, like hypnotism, had suffered from quacks, and if care was not taken it would get into bad odour, and whatever use there was to be obtained from it would be lost sight of.
Pulmonary Arterial Hypertension in France
Authors: Marc Humbert, Olivier Sitbon, Ari Chaouat, Michèle Bertocchi, Gilbert Habib, Virginie Gressin, Azzedine Yaici, Emmanuel Weitzenblum, Jean-François Cordier, François Chabot, Claire Dromer, Christophe Pison, Martine Reynaud-Gaubert, Alain Haloun, Marcel Laurent, Eric Hachulla, Gérald Simonneau
Journal: American Journal of Respiratory and Critical Care Medicine (2006)

Rationale: Pulmonary arterial hypertension (PAH) is an orphan disease for which the trend is for management in designated centers with multidisciplinary teams working in a shared-care approach.Objective: To describe clinical and hemodynamic parameters and to provide estimates for the prevalence of patients diagnosed for PAH according to a standardized definition.Methods: The registry was initiated in 17 university hospitals following at least five newly diagnosed patients per year. All consecutive adult (⩾ 18 yr) patients seen between October 2002 and October 2003 were to be included.Main Results: A total of 674 patients (mean ± SD age, 50 ± 15 yr; range, 18–85 yr) were entered in the registry. Idiopathic, familial, anorexigen, connective tissue diseases, congenital heart diseases, portal hypertension, and HIV-associated PAH accounted for 39.2, 3.9, 9.5, 15.3, 11.3, 10.4, and 6.2% of the population, respectively. At diagnosis, 75% of patients were in New York Heart Association functional class III or IV. Six-minute walk test was 329 ± 109 m. Mean pulmonary artery pressure, cardiac index, and pulmonary vascular resistance index were 55 ± 15 mm Hg, 2.5 ± 0.8 L/min/m2, and 20.5 ± 10.2 mm Hg/L/min/m2, respectively. The low estimates of prevalence and incidence of PAH in France were 15.0 cases/million of adult inhabitants and 2.4 cases/million of adult inhabitants/yr. One-year survival was 88% in the incident cohort.Conclusions: This contemporary registry highlights current practice and shows that PAH is detected late in the course of the disease, with a majority of patients displaying severe functional and hemodynamic compromise.
The Present Position Relating to Cancer of the Lung : Symposium by the Thoracic Society
Authors: G. A. Mason
Journal: Thorax (1960)

From Newcastle upon Tyne More than 20% of men and 5 % of women dying of cancer die of cancer of the lung.Each year some 400 such patients pass through our wards in the Newcastle Centre at Shotley Bridge serving a population of about three million.We see perhaps only a third or at most a half of the cases occurring in the region; only about half of these are thought worthy of admission, and of these rather less than half reach the operating table, rather more than half of these proving operable.Although there is virtually no delay in the admission of a case once the diagnosis is suspected, there has been no material improvement in this position during the last decade.This is probably the general experience, and in many quarters leads to an attitude of discouragementif not of despair.Faced with a large number of individual cases already too advanced for treatment when first referred, those working in this field may understandably take a far from rosy view of the problem.Many reputable physicians perhaps take the view that treatment is justified neither by the immediate nor the late results, both as regards survival and physical fitness.Fortunately within the last two or three years, surveys from several large centres have done something to correct such impressions.Accordingly your Council felt it was desirable that a survey of the present position should be brought to the notice of the Society, and I was entrusted with this task.The simplest-and of course for me the easiest-way was to arrange this symposium, the contributors to which can all speak authoritatively on the different aspects.Bad selection of cases and as bad surgical and clinical judgment are probably the most likely explanations of both an excessive operativeThe Thoracic Society held a symposium on this subject in Oxford in the summer of 1959, and the following are the papers read on that occasion.Mr. H. C. NOHL will tell us of the prognostic deductions possible from studies of the pulmonary veins and of the lymphatic glands removed at on August 20,
Facts and Fancies About Cancer of the Lung
Authors: D. W. Smithers
Journal: BMJ (1953)

<h3>Background:</h3> Medicine is full of value conflicts. Limited resources and legal regulations may place doctors in difficult ethical dilemmas and cause moral distress. Research on moral distress has so far been mainly studied in nurses. <h3>Objective:</h3> To describe whether Norwegian doctors experience stress related to ethical dilemmas and lack of resources, and to explore whether the doctors feel that they have good strategies for the resolution of ethical dilemmas. <h3>Design:</h3> Postal survey of a representative sample of 1497 Norwegian doctors in 2004, presenting statements about different ethical dilemmas, values and goals at their workplace. <h3>Results:</h3> The response rate was 67%. 57% admitted that it is difficult to criticise a colleague for professional misconduct and 51% for ethical misconduct. 51% described sometimes having to act against own conscience as distressing. 66% of the doctors experienced distress related to long waiting lists for treatment and to impaired patient care due to time constraints. 55% reported that time spent on administration and documentation is distressing. Female doctors experienced more stress that their male colleagues. 44% reported that their workplace lacked strategies for dealing with ethical dilemmas. <h3>Conclusion:</h3> Lack of resources creates moral dilemmas for physicians. Moral distress varies with specialty and gender. Lack of strategies to solve ethical dilemmas and low tolerance for conflict and critique from colleagues may obstruct important and necessary ethical dialogues and lead to suboptimal solutions of difficult ethical problems.
<i>ERAP2</i>is associated with ankylosing spondylitis in<i>HLA-B27</i>-positive and<i>HLA-B27-</i>negative patients
Authors: Philip C Robinson, Mary-Ellen Costello, Paul Leo, Linda A Bradbury, Kelly Hollis, Adrian Cortes, Seunghun Lee, Kyung Bin Joo, Seung-Cheol Shim, Michael Weisman, Michael Ward, Xiaodong Zhou, Henri-Jean Garchon, Gilles Chiocchia, Johannes Nossent, Benedicte A Lie, Øystein Førre, Jaakko Tuomilehto, Kari Laiho, Lei Jiang, Yu Liu, Xin Wu, Dirk Elewaut, Ruben Burgos-Vargas, Lianne S Gensler, Simon Stebbings, Nigil Haroon, Juan Mulero, Jose Luis Fernandez-Sueiro, Miguel A Gonzalez-Gay, Carlos Lopez-Larrea, Paul Bowness, Karl Gafney, John S Hill Gaston, Dafna D Gladman, Proton Rahman, Walter P Maksymowych, Huji Xu, Irene E van der Horst-Bruinsma, Chung-Tei Chou, Raphael Valle-Oñate, María Consuelo Romero-Sánchez, Inger Myrnes Hansen, Fernando M Pimentel-Santos, Robert D Inman, Javier Martin, Maxime Breban, David Evans, John D Reveille, Tae-Hwan Kim, B Paul Wordsworth, Matthew A Brown
Journal: Annals of the Rheumatic Diseases (2015)

ERAP2 is associated with ankylosing spondylitis in HLA-B27positive and HLA-B27-negative patientsA full list of authors and affiliations appears at the end of the article.3][4][5] Subsequent investigation demonstrated an association of ERAP2 with AS which was present when one conditioned on one of the two independent haplotypes of ERAP1 associated with AS or when HLA-B27-negative patients were analysed separately. 1 These two analyses provide analogous evidence for the association of ERAP2 with AS in HLA-B27-negative cases because of the genetic interaction between HLA-B27 and the ASassociated ERAP1 variants in AS cases.ERAP1 and ERAP2 are located on chromosome 5q15 in the opposite orientation.The locus is challenging to analyse because of the strong linkage disequilibrium (LD) across the locus and the epistasis between ERAP1 and HLA-B alleles associated with AS.We therefore sought to investigate the association of ERAP2 with AS in HLA-B27-positive patients. 6This is of clinical importance because functional studies have demonstrated that the strongly AS-protective variant rs2248374 causes a functional ERAP2 protein knockout, because its G allele causes a loss of ERAP2 protein expression. 57 There is also a variant of ERAP2 which changes its enzyme catalytic activity and specificity (rs2549782, K392A 8 ).Because this is in almost complete LD with rs2248374 (1000 Genomes D′=1.00, r 2 =0.90), it is almost never translated in vivo.Further, the very strong LD between these markers means that analysis of rs2549782 for association would yield results almost identical to the results for rs2248374 presented below.Therefore, it is of relevance to determine whether the association of ERAP2 with HLA-B27-negative disease is also found in HLA-B27-positive cases, since ERAP inhibition may offer a novel therapeutic for AS.
Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis
Authors: John Bowes, Edward Flynn, Pauline Ho, Batool Aly, Ann W Morgan, Helena Marzo-Ortega, Laura Coates, Ross McManus, Anthony W Ryan, David Kane, Eleanor Korendowych, Neil McHugh, Oliver FitzGerald, Jonathan Packham, Ian N Bruce, Anne Barton
Journal: Annals of the Rheumatic Diseases (2010)

Objective A common deletion mapping to the psoriasis susceptibility locus 4 on chromosome 1q21, encompassing two genes of the late cornified envelope (LCE) gene cluster, has been associated with an increased risk of psoriasis vulgaris (PsV). One previous report found no association of the deletion with psoriatic arthritis (PsA), suggesting it may be a specific risk factor for PsV. Given the genetic overlap between PsA and PsV, a study was undertaken to investigate whether single nucleotide polymorphisms (SNPs) mapping to this locus are risk factors for PsA in a UK and Irish population. Methods Three SNPs with prior evidence of association with susceptibility to PsV were genotyped in 1057 patients with PsA using Sequenom iPlex chemistry and genotype frequencies compared with data available for 5575 healthy controls. Two of the SNPs, rs4112788 and rs4085613, were reported to be highly correlated with the LCE deletion. The third SNP, rs6701216, was previously reported to be associated with PsV in a US population. Results Alleles tagging the deletion for both rs4112788 and rs4085613 were found to be enriched in cases compared with controls (69% vs 65%) and significantly associated with increased susceptibility to PsA (p trend = 0.001, OR 1.19 and p trend = 0.001, OR 1.18, respectively). No association was observed with rs6701216. Conclusions The evidence presented here supports LCE deletion as a risk factor for PsA in a UK and Irish population. It suggests that this locus is a risk factor within a shared aetiological pathway that contributes to psoriatic skin disease in both PsV and PsA.
Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice
Authors: R. Glauben, A. Batra, T. Stroh, U. Erben, I. Fedke, H. A. Lehr, F. Leoni, P. Mascagni, C. A. Dinarello, M. Zeitz, B. Siegmund
Journal: Gut (2008)

<h3>ABSTRACT</h3> The field of cross-linking mass spectrometry has matured to a frequently used tool for the investigation of protein structures as well as interactome studies up to a system wide level. The growing community generated a broad spectrum of applications, linker types, acquisition strategies and specialized data analysis tools, which makes it challenging, especially for newcomers, to decide for an appropriate analysis workflow. Therefore, we here present a large and flexible synthetic peptide library as reliable instrument to benchmark crosslinkers with different reactive sites as well as acquisition techniques and data analysis algorithms. Additionally, we provide a tool, IMP-X-FDR, that calculates the real, experimentally validated, FDR, compares results across search engine platforms and analyses crosslink properties in an automated manner. The library was used with the reagents DSSO, DSBU, CDI, ADH, DHSO and azide-a-DSBSO and data were analysed using the algorithms MeroX, MS Annika, XlinkX, pLink 2, MaxLynx and xiSearch. We thereby show that the correct algorithm and search setting choice is highly important to improve ID rate and FDR in combination with software and sample-complexity specific score cut-offs. When analysing DSSO data with MS Annika, we reach high identification rates of up to ∼70 % of the theoretical maximum (i.e. 700 unique lysine-lysine cross-links) while maintaining a low real FDR of &lt; 3 % at cross-link level and with high reproducibility, representatively showing that our test system delivers valuable and statistically solid results. <h3>Graphical abstract</h3>
Mechanisms of Sudden Cardiac Death
Authors: Kai-Chien Yang, John W. Kyle, Jonathan C. Makielski, Samuel C. Dudley
Journal: Circulation Research (2015)

Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged cardiac metabolism and abnormal redox state during cardiac diseases foment arrhythmogenic substrates through direct or indirect modulation of cardiac ion channel/transporter function. This review presents current evidence on the mechanisms linking metabolic derangement and excessive oxidative stress to ion channel/transporter dysfunction that predisposes to ventricular arrhythmias and SCD. Because conventional antiarrhythmic agents aiming at ion channels have proven challenging to use, targeting arrhythmogenic metabolic changes and redox imbalance may provide novel therapeutics to treat or prevent life-threatening arrhythmias and SCD.
Clinical pulmonary infection score for ventilator-associated pneumonia: accuracy and inter-observer variability
Authors: Carolina A. M. Schurink, Christianne A. Van Nieuwenhoven, Jan A. Jacobs, Maja Rozenberg-Arska, Hans C. A. Joore, Erik Buskens, Andy I. M. Hoepelman, Marc J. M. Bonten
Journal: Intensive Care Medicine (2004)
Circulating <i>MYCN</i> DNA Predicts <i>MYCN</i>-Amplification in Neuroblastoma
Authors: Valérie Combaret, Christophe Bergeron, Rosa Noguera, Isabelle Iacono, Alain Puisieux
Journal: Journal of Clinical Oncology (2005)

levels in healthy breast tissue vary cyclically.We recognize this, and it is one reason that the staining in normal tissue is not an ideal positive control.The majority of patients in our cohort were postmenopausal.Our service is closely associated with a mammographic breast screening service, and the majority of cases in this cohort were screen detected.The target age group for screening in Australia is between the ages of 50 to 75 years.Thus, our study is primarily of postmenopausal breast cancer patients, in whom the hormonal milieu does not undergo cyclical variations.For all of our results, the trend was in the same direction-more staining in the core biopsy specimen than in the surgical specimen-strongly suggesting that the result is due to the nature of the specimen, rather than another factor that should vary equally in both directions.In addition, we have no policy regarding timing of diagnostic biopsy or surgery according to menstrual cycle, and so staining in premenopausal patients would be expected to vary in both directions if hormonal milieu when the specimen was taken was a determining factor.We considered including a subclassification of menopausal status.However in our series of 100 patients, there were only eight patients 50 years or younger, and the Allred ER and PR score in all eight cases was equal or was higher in the core biopsy specimen than in the surgical specimen.None of the nine patients who would have had a falsenegative receptor assessment, according to the surgical specimen results, were younger than 50 years.The median age of the nine patients was 64 years (range, 53 to 75 years).We agree that cyclical variation of ER, PR, and HER-2 levels is worthy of further study.In light of our results, it is critical that such study be based on core biopsy samples, to prevent the results being confounded.
Identification of <i>Las2</i>, a Major Modifier Gene Affecting the Pas1 Mouse Lung Tumor Susceptibility Locus
Authors: Peng-Yuan Liu, Haris Vikis, Michael James, Yan Lu, Dao-Long Wang, Hong-Bo Liu, Wei-Dong Wen, Yian Wang, Ming You
Journal: Cancer Research (2009)

Lung cancer is the leading cause of cancer death worldwide. Here, we describe a genome-wide association study of chemically induced lung tumorigenesis on 593 mice from 21 inbred strains using 115,904 genotyped and 1,952,918 imputed single nucleotide polymorphisms (SNPs). Using a genetic background-controlled genome search, we identified a novel lung tumor susceptibility gene Las2 (Lung adenoma susceptibility 2) on distal chromosome 18. Las2 showed strong association with resistance to tumor induction (rs30245983; P = 1.87 x 10(-9)) as well as epistatic interactions (P = 1.71 x 10(-3)) with the pulmonary adenoma susceptibility 1 locus, a major locus affecting mouse lung tumor development (rs13459098, P = 5.64 x 10(-27)). Sequencing analysis revealed four nonsynonymous SNPs and two insertions/deletions in the susceptible allele of Las2, resulting in the loss of tumor suppressor activities in both cell colony formation and nude mouse tumorigenicity assays. Deletion of LAS2 was observed in approximately 40% of human lung adenocarcinomas, implying that loss of function of LAS2 may be a key step for lung tumorigenesis.
703 EVIDENCE FOR DIFFERENTIAL ADAPTATION OF HEPATITIS C VIRUS IN POPULATIONS WITH DIFFERENT HLA-CLASS I-BACKGROUND
Authors: M. Ruhl, T. Knuschke, M. Wiese, H. Tenckhoff, J. Nattermann, U. Spengler, M. Roggendorf, D. Hoffmann, J. Timm
Journal: Journal of Hepatology (2010)
Basis of CTLA-4 function in regulatory and conventional CD4+ T cells
Authors: Xuguang Tai, François Van Laethem, Leonid Pobezinsky, Terry Guinter, Susan O. Sharrow, Anthony Adams, Larry Granger, Michael Kruhlak, Tullia Lindsten, Craig B. Thompson, Lionel Feigenbaum, Alfred Singer
Journal: Blood (2012)
Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck
Authors: A. Argiris, A.P. Kotsakis, T. Hoang, F.P. Worden, P. Savvides, M.K. Gibson, R. Gyanchandani, G.R. Blumenschein, H.X. Chen, J.R. Grandis, P.M. Harari, M.S. Kies, S. Kim
Journal: Annals of Oncology (2012)
Letter by Irion Regarding Article, “Systemic and Pulmonary Vascular Dysfunction in Children Conceived by Assisted Reproductive Technologies”
Authors: Olivier Irion
Journal: Circulation (2013)

1 This research was largely advertised in a Swiss television show, 36.9, on April 4, 2012. 2 In this show, it was clearly evident that children conceived by assisted reproduction techniques were informed of the hypothesis of the study before the measurements, that they were at risk to be victims of heart infarction at a very young age, and that their vascular system and pulmonary pressure might be a problem.In my opinion, the authors should consider the possibility that informing the children and their parents might have confounded the results.For example, this action might have induced emotional stress that altered vascular function.I thank the authors for their interest in this clinically important topic.Two to 5% of children are born after assisted reproduction techniques in developed countries.As a randomized trial to avoid biases is obviously not conceivable, future research to eventually confirm these results will be important for the children born after assisted reproduction techniques and their families.
Reduced susceptibility of mice overexpressing transforming growth factor α to dextran sodium sulphate induced colitis
Authors: B Egger, H V Carey, F Procaccino, N-N Chai, E P Sandgren, J Lakshmanan, V S Buslon, S W French, M W Büchler, V E Eysselein
Journal: Gut (1998)

Background —Transforming growth factor α (TGF-α) knockout mice have increased susceptibility to dextran sodium sulphate (DSS) induced colitis. Aim —To substantiate the findings that TGF-α is a key mediator of colonic mucosal protection and/or repair mechanisms by evaluating the susceptibility of mice overexpressing TGF-α to DSS induced colitis. Methods —TGF-α overexpression was induced in transgenic mice by ZnSO 4 administration in drinking water (TG+). Three groups were used as controls: one transgenic group without ZnSO 4 administration (TG−), and two non-transgenic littermate groups receiving ZnSO 4 (Non-TG+) or only water (Non-TG−). Acute colitis was induced in all groups by administration of DSS (5%, w/v) in drinking water for six days ad libitum. Results —About 35–39% of the entire colonic mucosa was destroyed in Non-TG−, Non-TG+, and TG− animals compared with 9% in TG+ mice. The crypt damage score was 18.7 (0.9), 18.2 (1.0), 18.9 (0.8), and 6.8 (1.5) (means (SEM)) in Non-TG−, Non-TG+, TG−, and TG+ mice respectively. Mucin and bromodeoxyuridine staining were markedly enhanced in colons of TG+ mice compared with controls, indicating increased mucosal protection and regeneration. Conclusions —The significantly reduced susceptibility of mice overexpressing TGF-α to DSS further substantiates that endogenous TGF-α is a pivotal mediator of protection and/or healing mechanisms in the colon.