tbuckley/cabot-search huggingface dataset:
Heterogeneity of the Induction of HLA-DR Expression by Human Immune Interferon on Glioma Cell Lines and Their Clones&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: V Piguet, S Carrel, A C Diserens, J P Mach, N de Tribolet
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Heterogeneity of the Induction of HLA-DR Expression by Human Immune Interferon on Glioma Cell Lines and Their Clones Get access Valérie Piguet, Valérie Piguet Search for other works by this author on: Oxford Academic PubMed Google Scholar Stefan Carrel, Stefan Carrel Search for other works by this author on: Oxford Academic PubMed Google Scholar Annie-Claire Diserens, Annie-Claire Diserens Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean-Pierre Mach, Jean-Pierre Mach Search for other works by this author on: Oxford Academic PubMed Google Scholar Nicolas Tribolet de Nicolas Tribolet de Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 76, Issue 2, February 1986, Pages 223–228, https://doi.org/10.1093/jnci/76.2.223 Published: 01 February 1986 Article history Received: 02 April 1985 Revision received: 11 September 1985 Accepted: 07 October 1985 Published: 01 February 1986
GENO-22TWO DNA TESTS ACCURATELY CLASSIFY GLIOMAS INTO FIVE MOLECULAR GROUPS AND PROVIDE ADDITIONAL INFORMATION ON ACQUIRED ALTERATIONS
Authors: Seiji Yamada, Daniel Lachance, Cristiane Ida, Thomas Kollmeyer, Jesse Voss, Corinne Praska, Emily Barr Fritcher, Caterina Gianinni, Benjamin Kipp, Jeanette Eckel-Passow, Robert Jenkins
Journal: Neuro-Oncology (2015)

BACKGROUND: It has recently been shown that adult gliomas can be categorized into five molecular groups based on IDH mutation, 1p/19q codeletion and TERT promoter mutation (Eckel-Passow et al. N Engl J Med 2015 Epub Jun 10). We developed two genomics tests to assess these alterations and the other acquired alterations that are associated with the five glioma molecular groups. METHODS: DNA was isolated from 137 formalin-fixed, paraffin-embedded (FFPE) Mayo Clinic adult gliomas. First, copy number variants (CNV) and copy neutral loss of heterozygosity (cnLOH) were evaluated using the OncoScan platform (Affymetrix). Second, 50 genes commonly mutated in brain tumors – including TERT and IDH - were evaluated by multiplex PCR and pooled next-generation sequencing. The 50-gene panel included TP53 and ATRX. RESULTS: Together, the OncoScan CNV/cnLOH array and the 50-gene panel classified 135 (99%) of the gliomas into one of the five molecular groups: 29 (21%) Triple-Positive; 6 (4%) TERT- and IDH-mutation; 36 (26%) IDH-mutation only; 2 (1%) Triple-Negative; and 62 (45%) TERT-mutation only. Two (1%) had other patterns. Interesting findings included: Among the IDH-mutation only gliomas, all (100%) acquired a TP53 alteration and 31 (86%) an ATRX alteration. CnLOH of 17p (including TP53) was observed in 22 gliomas; 19 were IDH-mutation only. Acquired TP53 alterations were observed in all 22 tumors with 17p cnLOH. While most tumors were either TERT or ATRX mutated, some had mutations in both genes and some in neither. CIC and/or FUBP1 mutations were detected in 21 (72%) of the Triple-Positive gliomas. CnLOH of 9p was observed in 4 (14%) Triple-Positive gliomas. CONCLUSIONS: Two genomics tests using FFPE material can effectively classify gliomas into one of five molecular groups. The tests also identify common acquired alterations associated with these groups. These tests will be a significant adjunct to the clinical diagnosis of adult gliomas.
Combined phenotypical and functional analysis of M. tuberculosis specific immunity for diagnosing active infection and risk assessment in latently infected individuals
Authors: Jan Dirks, Matthias Fousse, Urban Sester, Martina Sester
Journal: European Respiratory Journal (2014)

Tuberculin skin testing or interferon-γ release assays (IGRAs) are used for  M. tuberculosis  (TB) contact tracing. Whereas IGRAs allow discriminating TB-specific immunity from BCG vaccination responses, they cannot distinguish active (A-TB) from latent (L-TB) or successfully treated (T-TB) infection. We have previously shown that IFN-γ–IL-2 cytokine profiling of PPD specific T-cells may more specifically diagnose active TB. The aim of this study was to combine cytokine profiling with phenotypical analysis of CTLA-4 and CD27 to improve diagnostic accuracy.  We performed 6h stimulation with PPD, ESAT-6 and CFP-10 antigens with subsequent flow cytometric analysis of whole blood samples from a total of 58 confirmed A-TB patients, 34 patients with T-TB, 127 individuals with L-TB and 386 with immunity consistent with BCG vaccination or NTM infection.  A loss of CD27 on PPD specific T-cells discriminated best between A-TB and T-TB (100% specificity, 83.3% sensitivity AUC=0.93%). Likewise, increased expression of CTLA-4 discriminated with 88.9% specificity and 72.5% sensitivity (AUC=0.84). Combined analysis of CD27 with CTLA-4 but not with IFNγ–IL-2 further increased diagnostic power. Among 25 individuals with L-TB identified in the setting of contact tracing, 48% expressed one or more markers similarly to patients with A-TB, whereas 52% did not show any alterations in T-cell immunity.  In conclusion, combined functional and phenotypical analysis of TB specific T-cells might improve immune based diagnosis of active TB, and to-be more specifically predict the risk of progression towards A-TB in the setting of contact tracing.
Erratum to “The puzzle of intrafamilial child sexual abuse: A meta-analysis comparing intrafamilial and extrafamilial offenders with child victims” [Clin. Psychol. Rev. 39 (2015) 42–57]
Authors: Michael C. Seto, Kelly M. Babchishin, Lesleigh E. Pullman, Ian V. McPhail
Journal: Clinical Psychology Review (2016)
Clustering and subfamily relationships of the Alu family in the human genome.
Authors: V Slagel, E Flemington, V Traina-Dorge, H Bradshaw, P Deininger
Journal: Molecular Biology and Evolution (1987)

Thirteen and 10 sequences of the Alu family of repeated DNA elements found within the human thymidine kinase and beta-tubulin genes, respectively, were compared. These genes have approximately five times the expected density of Alu family members. The consensus sequence that could be drawn from these 23 Alu family members would differ slightly from others drawn from random Alu family sequences but only at very heterogeneous positions. The different Alu family members do show different pairwise percentage identities, with approximately 15% (7 of 48 Alu family members analyzed) of them clearly representing a separate subfamily of sequences. This analysis also confirms the species-specific differences between human and the prosimian Galago crassicaudatus Alu family members. These data are consistent with both the origin of these sequences in primates less than 65-70 Myr ago and amplification since that time to their present 500,000 copies. The data do not show any special relationships among densely clustered Alu family members.
NCO-04A PILOT RCT ON THE EFFICACY OF E-HEALTH SUPPORTED PHYSICAL EXERCISE TO IMPROVE COGNITIVE FUNCTIONING IN GLIOMA PATIENTS
Authors: Karin Gehring, Martijn Stuiver, Geert-Jan Rutten, Martin Taphoorn, Neil Aaronson, Margriet Sitskoorn
Journal: Neuro-Oncology (2015)

BACKGROUND: Physical exercise (PE) has proven effective in ameliorating cognitive deficits in older adults and select neurological patient populations. This pilot RCT investigates a PE program for improving cognitive deficits in glioma patients. METHODS: Patients with stable grades II/III glioma were randomized 2:1 to a home-based PE group or a control group. Patients in the PE group performed three 20-45 minute sessions per week of self-chosen aerobic exercise for 6 months. Intensity varied from 60 to 85% of maximum heart rate, based on maximal cardiopulmonary exercise testing (CPET). Participants wore heart rate monitors and were supervised by a physical therapist via internet and telephone. Patients in the active control group were advised to walk regularly. Baseline and outcome assessment at 6 months included physical fitness (VO2peak determined by CPET) and cognitive performance (attention, information processing, memory, executive function, determined by neuropsychological assessment), among other measures. RESULTS: Thirty-four patients were included and randomized; 23 to the PE group and 11 to the control group. There were no baseline differences. Patients in the PE group completed on average 78% of the prescribed training sessions. Preliminary analyses indicated an increase of physical fitness of 7.2% in the PE group (n = 18) and a decline of 2.6% in the control group (n = 9; mean difference of change 2.60 ml/kg*min, 95%CI 0.00 to 5.20, p = .05). Concerning cognitive outcomes, favourable mean differences of change scores for the PE group (n = 20 versus controls (n = 11)) were observed on a measure of information processing speed (5.72; −0.45 to 11.89, p = .07), immediate verbal recall (0.76, −0.06 to 1.59, p = .07), and selective attention and working memory (1.53, −0.08 to 3.15; p = .06). Final results will be presented at the conference. CONCLUSIONS: These preliminary results in a small sample show the feasibility of the intervention, and suggest that it may lead to cognitive benefits.
A Prospective Survey of Familial Canine Lymphosarcoma&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: D E Onions
Journal: JNCI Journal of the National Cancer Institute (1984)

The incidence and case distribution of lymphosarcoma were determined prospectively in one breed of dogs, the bull mastiff. Fifty-nine dogs from three households were followed for 3 years. Two of the households had a previous history of lymphosarcoma cases, whereas the third had no history of such cases. During the survey period, 9 of the 59 dogs died from lymphosarcoma with multiple cases occurring in each household. On the basis of this survey, the annual incidence rate in the general bull mastiff population is likely to be on the order of 5,000 cases per 100,000 dogs, which constitutes the highest incidence rate recorded in this species. The distribution of the cases displayed a familial pattern. The possible involvement of genetic and infectious factors in the development of this disease pattern is discussed.
Weightings for analysing general practices' prescribing
Authors: S. J Roberts
Journal: BMJ (1996)

findings can be applied to female genital mutilation occurring in a totally different cultural setting.Finally, as paediatricians we condemn male circumcision; we were putting it into the context of the more extensive operations in females.It is now more than 46 years since Gairdner, in a classic paper, demolished the case for routine male circumcision.'
Platelets: No longer bystanders in liver disease
Authors: Abhishek Chauhan, David H. Adams, Steve P. Watson, Patricia F. Lalor
Journal: Hepatology (2016)

Growing lines of evidence recognize that platelets play a central role in liver homeostasis and pathobiology. Platelets have important roles at every stage during the continuum of liver injury and healing. These cells contribute to the initiation of liver inflammation by promoting leukocyte recruitment through sinusoidal endothelium. They can activate effector cells, thus amplifying liver damage, and by modifying the hepatic cellular and cytokine milieu drive both hepatoprotective and hepatotoxic processes. Conclusion: In this review we summarize how platelets drive such pleiotropic actions and attempt to reconcile the paradox of platelets being both deleterious and beneficial to liver function; with increasingly novel methods of manipulating platelet function at our disposal, we highlight avenues for future therapeutic intervention in liver disease . (H epatology 2016;64:1774‐1784)
Identification of <i>STOML2</i> as a putative novel asthma risk gene associated with <i>IL6R</i>
Authors: J. A. Revez, M. C. Matheson, J. Hui, S. Baltic, A. James, J. W. Upham, S. Dharmage, P. J. Thompson, N. G. Martin, J. L. Hopper, M. A. R. Ferreira
Journal: Allergy (2016)

Abstract Background Functional variants in the interleukin‐6 receptor gene ( IL 6R ) are associated with asthma risk. We hypothesized that genes co‐expressed with IL 6R might also be regulated by genetic polymorphisms that are associated with asthma risk. The aim of this study was to identify such genes. Methods To identify genes whose expression was correlated with that of IL 6R , we analyzed gene expression levels generated for 373 human lymphoblastoid cell lines by the Geuvadis consortium and for 38 hematopoietic cell types by the Differentiation Map Portal ( DMAP ) project. Genes correlated with IL 6R were then screened for nearby single nucleotide polymorphisms ( SNP s) that were significantly associated with both variation in gene expression levels ( eSNP s) and asthma risk. Results We identified 90 genes with expression levels correlated with those of IL 6R and that also had a nearby eSNP associated with disease risk in a published asthma GWAS ( N = 20 776). For 16 (18%) genes, the association between the eSNP and asthma risk replicated with the same direction of effect in a further independent published asthma GWAS ( N = 27 378). Among the top replicated associations ( FDR &lt; 0.05) were eSNP s for four known ( IL 18R1 , IL 18 RAP , BCL 6 , and STAT 6 ) and one putative novel asthma risk gene, stomatin‐like protein 2 ( STOML 2 ). The expression of STOML 2 was negatively correlated with IL 6R , while eSNP s that increased the expression of STOML 2 were associated with an increased asthma risk. Conclusion The expression of STOML 2 , a gene that plays a key role in mitochondrial function and T‐cell activation, is associated with both IL ‐6 signaling and asthma risk.
Which Patients With Microscopic Disease and Rhabdomyosarcoma Experience Relapse After Therapy? A Report From the Soft Tissue Sarcoma Committee of the Children’s Oncology Group
Authors: Lynn M. Smith, James R. Anderson, Stephen J. Qualman, William M. Crist, Charles N. Paidas, Lisa A. Teot, Alberto S. Pappo, Michael P. Link, Holcombe E. Grier, Eugene S. Wiener, John C. Breneman, R. Beverly Raney, Harold M. Maurer, Sarah S. Donaldson
Journal: Journal of Clinical Oncology (2001)

PURPOSE: To identify which patients with rhabdomyosarcoma and microscopic residual disease (group II) are likely to not respond to therapy. PATIENTS AND METHODS: Six hundred ninety-five patients with group II tumors received chemotherapy and 90% received radiation therapy on Intergroup Rhabdomyosarcoma Study (IRS)-I to IRS-IV (1972 to 1997). Tumors were subgrouped depending on the presence of microscopic residual disease only (subgroup IIa), resected positive regional lymph nodes, (subgroup IIb), or microscopic residual disease and resected positive regional lymph nodes (subgroup IIc). RESULTS: Overall, the 5-year failure-free survival rate (FFSR) was 73%, and patients with embryonal rhabdomyosarcoma treated on IRS-IV fared especially well (5-year FFSR, 93%; n = 90). Five-year FFSRs differed significantly by subgroup (IIa, 75% and n = 506; IIb, 74% and n = 101; IIc, 58% and n = 88; P = .0037) and treatment (IRS-I, 68%; IRS-II, 67%; IRS-III, 75%; IRS-IV, 87%; P &lt; .001). Multivariate analysis revealed positive associations between primary site (favorable), histology (embryonal), subgroup IIa or IIb, treatment (IRS-III/IV), and better FFSRs. Patterns of treatment failure revealed local failure to be 8%, regional failure, 4%, and distant failure, 14%. The relapse pattern noted over the course of IRS-I to IRS-IV shows a decrease in the systemic relapse rates, particularly for patients with embryonal histology, suggesting that improvement in FFSRs is primarily a result of improved chemotherapy. CONCLUSION: Group II rhabdomyosarcoma has an excellent prognosis with contemporary therapy as used in IRS-III/IV, and those less likely to respond can be identified using prognostic factors: histology, subgroup, and primary site. Patients with embryonal rhabdomyosarcoma are generally cured, although patients with alveolar rhabdomyosarcoma or undifferentiated sarcoma, particularly subgroup IIc at unfavorable sites, continue to need better therapy.
Epidemiologic predictors of the risk of clinical recurrence in men diagnosed with prostate cancer
Authors: M. S. Cyrus-David, S. Strom
Journal: Journal of Clinical Oncology (2004)

4658 Background: some prostate cancers (PC) are known to be rapidly progressive and fatal requiring active treatment while others are not. We examined the epidemiological and clinical factors associated with the low-, intermediate- or high-risk of clinical recurrence of PC. Methods: we analyzed data of 1235 consecutive patients treated for PC at The University of Texas M. D. Anderson Cancer Center, Houston, Texas. Men aged 40 to 87 years underwent a structured interview administered by trained interviewers between 1996 and 2002. The patients were then stratified into the low–risk (LR) (n=565), intermediate-risk (IR) (n=403), or high-risk (HR) of clinical recurrence (n=267) based on pretreatment prostate-specific antigen levels, biopsy Gleason scores, and clinical T stage. Data were analyzed using chi square test, analysis of variance and logistic regression analyses. Results: Multivariate analyses showed that older men were more likely in the LR group (OR, 2.73, 95% Confidence Interval 2.04–3.67 for 60–69 years group; OR, 1.81, 1.18–2.78 for ≥ 70 years group) and were less likely in the IR (OR, 0.51, 0.38–0.69 for 60–69 years of age) or HR groups (OR, 0.57, 0.41–0.80 for 60–69 years of age; OR, 0.58, 0.36–0.95 for ≥ 70 years of age with <60 years as the reference group.) Caucasians were more likely in the HR group (OR, 2.27, 1.18–4.39) as were African Americans (OR, 2.24, 1.09–4.60) when compared with Hispanics. Patients in the upper quartiles of body weight at 40 years of age were less likely in the LR group (OR, 0.61, 0.38–0.98 for the third quartile) but were more likely in the HR group (OR, 1.77, 1.09–2.87 for the second quartile; OR, 1.73, 1.01–2.96 for the third quartile) with the lowest quartile as the reference group. Patients with upper quartiles of biceps skin fold thickness were less likely in the LR group (OR, 0.49, 0.25–0.97 for the second quartile) but were more likely in the HR group (OR, 2.57, 1.15–5.75 for the third quartile.) Conclusions: Our findings indicate the younger men, Caucasians, and African Americans, and men who were obese were more likely to be diagnosed with PC of IR and HR of clinical recurrence when compared with patients in the LR group. No significant financial relationships to disclose.
Epigenetic Deregulation In Relapsed Acute Myeloid Leukemia
Authors: Francine E. Garrett-Bakelman, Sheng Li, Todd Hricik, Stephen S. Chung, Haim Bar, Anna L Brown, Jay P. Patel, Franck Rapoport, Lin Liu, Caroline Sheridan, Jennifer Ishii, Paul Zumbo, Jorge Gandara, Ian D Lewis, Luen Bik To, Michael W. Becker, Monica L. Guzman, Richard J D'Andrea, Franziska Michor, Christopher Y. Park, Martin Carroll, Ross L. Levine, Christopher E Mason, Ari M. Melnick
Journal: Blood (2013)
Lipopolysaccharide Stimulation of Plasmacytoma Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: M Platica, V P Hollander
Journal: JNCI Journal of the National Cancer Institute (1985)

Various preparations of lipopolysaccharides (LPS) were tested for their effect on 6 plasma tumor cell lines. LPS from Escherichia coli B5:055, Salmonella minnesota 1114, and R7 mutant, as well as the glycolipid from S. minnesota 595 were highly stimulatory on cell suspensions from solid transplantable plasma tumor cells MOPC 315 and MPC11, as measured by thymidine incorporation and cell proliferation. Even nanogram doses were effective. LPS preparations from S. minnesota R5 and endotoxin-free cell wall residues of R5 and R7 mutants of S. minnesota had no stimulatory effect on these cells. In contrast, 4 lines of tissue culture-adapted plasma tumor cells (Adj PC5, HOPC-1, MOPC-21, and MPC11 TC) were not affected by any LPS preparation tested. Lymphosarcoma P1798 cells were also unaffected by these LPS.
Comparaison des conséquences histologiques de 2 courants électriques chirurgicaux sur un modèle in vivo porcin de résection endoscopique de la muqueuse oesophagienne
Authors: E. Chabrun
Journal: Endoscopy (2016)

La sténose cicatricielle œsophagienne est une complication majeure et difficile à anticiper de la résection muqueuse œsophagienne étendue. Il pourrait exister un lien entre le courant électrique chirurgical (ESC) utilisé et l’apparition d’une sténose. Il existe un courant contrôlé par microprocesseur (MCC) qui, contrairement au courant de faible puissance (LPCC) utilisé habituellement, évite des pics de tension élevés censés entraîner des blessures thermiques profondes.
Next-Generation Sequencing Of ASXL1, TP53, RUNX1, EZH2, and ETV6 Identifies a Significant Proportion Of Lower-Risk Myelodysplastic Syndromes With Poor Prognostic Indicators
Authors: Brian Kwok, Renee Mohrmann, Kim Janatpour, Yin Xu, Matthew McGinniss, Aine Yung, Hong Drum, Keming Lin, Julie Kines, Jeffrey Tasmin, Bashar Dabbas
Journal: Blood (2013)
Safety and efficacy of repeated injections of botulinum toxin A in peripheral neuropathic pain (BOTNEP): a randomised, double-blind, placebo-controlled trial
Authors: Nadine Attal, Daniel C de Andrade, Frédéric Adam, Danièle Ranoux, Manoel J Teixeira, Ricardo Galhardoni, Irina Raicher, Nurcan Üçeyler, Claudia Sommer, Didier Bouhassira
Journal: The Lancet Neurology (2016)
Social inequalities in wheezing in children: findings from the UK Millennium Cohort Study
Authors: David C. Taylor-Robinson, Anna Pearce, Margaret Whitehead, Rosalind Smyth, Catherine Law
Journal: European Respiratory Journal (2015)

Wheezing in childhood is socially patterned, but it is unclear what factors explain the social differences. Regression analysis of the UK Millennium Cohort Study, based on 11 141 singleton children who participated at ages 9 months and 3, 5 and 7 years. Relative risk ratios (RRR) for early and persistent/relapsing wheeze were estimated using multinomial regression, according to measures of socioeconomic circumstances. Maternal, antenatal and early-life characteristics were assessed as potential mediators. Children of mothers with no educational qualifications were more likely to have both wheeze types, compared to children of mothers with degree-level qualifications (RRR 1.53, 95% CI 1.26–1.86 for early wheeze; 1.32 95% CI 1.04–1.67 for persistent/relapsing wheeze). Controlling for maternal age, smoking during pregnancy and breastfeeding removed the elevated risk of wheezing. Male sex, maternal age, body mass index, atopy, smoking during pregnancy, preterm birth, breastfeeding, exposure to other children and furry pets were independently associated with wheezing, but the pattern of association varied between wheezing types. In this representative UK cohort, adjustment for maternal smoking during pregnancy and breastfeeding removed the socioeconomic inequalities in common wheezing phenotypes. Policies to reduce the social gradient in these risk factors may reduce inequalities in wheezing and asthma.