tbuckley/cabot-search huggingface dataset:
AB1012 Contribution of Ultrasonography in the Diagnosis of the Very Early Rheumatoid Arthritis
Authors: W. Hamdi, R. Dhahri, M. Bouaziz, I. Chrif, N. Nouri, I. Zouch, D. Kaffel, M.F. Ladab, M.M. Kchir
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Imaging in early rheumatoid arthritis (RA) has undergone extraordinary change in recent years and new techniques are now available to help the clinician diagnose and manage patients much more effectively than previously. Ultrasound (US) examination could be of valuable help in the early diagnosis of RA. <h3>Objectives</h3> The present study is designed to assess the contribution of the US in diagnosis of the very early RA (within the first 6 months of the disease onset). <h3>Methods</h3> we conduct a cross sectional study of 36 consecutive patients with recent rheumatoid arthritis (less than 6 months of disease onset) diagnosed according to ACR-EULAR 2010 RA criteria. Patients have been clinically evaluated for pain and swelling of their hand joints, and underwent radiographs and sonography of the hand. The ultrasonography was made by the same radiologist who was unaware of clinical pattern using the same US machine (Philips HD 11) and high frequency linear probe 15 MHz. <h3>Results</h3> 28 women and 8 men were included. Their mean age was 48.3±1.15years (range: 16-74) and mean disease duration was 4.3±2.4 months (range 2-6 months). The disease have been active in all cases: mean DAS28 4.39±2.46. the mean tender joint count was 12. The mean swollen joint count was 5. The Rheumatoid factor was positive in 44.4% of cases and the ACPA was positive in 30% of cases. In 30% of cases, US had a valuable contribution in establishing RA diagnosis. In fact, among patients having no synovitis on examination, US showed at least one synovitis in 12 cases. In other 12 cases, bone erosions was found only on US (not shown on radiography). Radiography showed joint narrowing in 26 cases and bone erosion in 9 cases. The Sharp score was 7.58±8.36 in average. Ultrasounds showed erosion in 16 cases, joint synovitis in 29 cases, joint effusion in 18 cases and synovial hypertrophy in 24 cases with power doppler in 20 cases. <h3>Conclusions</h3> US is an accurate tool for the assessment of joint inflammation and bone erosion in patients with very early rheumatoid arthritis (RA). <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5677
Abstract P2-11-02: Perception and practice of reproductive specialists towards fertility preservation of young breast cancer patients
Authors: C Shimizu, T Kato, N Tamura, Y Asada, B Hiroko, Y Mizota, S Yamamoto, Y Fujiwara
Journal: Cancer Research (2012)

Abstract Background: The potential for infertility caused by treatment is one of the important quality-of-life issues in young breast cancer (YBC) patients. Insufficient communication and partnership between oncologists and reproductive specialists has been identified as a major barrier to meeting their needs. However, the perception of reproductive specialists towards fertility preservation (FP) of YBC has not been evaluated. Objective: To investigate the perception and needs of reproductive specialists towards FP of YBC patients. Methods: A cross-sectional survey was developed and sent to 423 certified reproductive specialists registered to the Japan Society for Reproductive Medicine to self-evaluate their perceptions and practices regarding FP in YBC patients. Results: Two hundred reproductive specialists (47%) responded to the survey. 99% responded that reproductive specialists should be engaged in FP of YBC patients. 46% responded that cancer treatment is more important than childbirth even if the patient was recurrence-free five years after primary treatment. 83% responded that they would like to treat YBC patients. Respondents affiliated with private clinics were more likely to accept both fertilized egg and unfertilized egg preservation than those affiliated with academic or general hospitals (p &amp;lt; 0.01). 58% responded that ovulation induction methods should be modified in YBC patients. The choice of ovulation induction methods varied both in non-cancer women and YBC patients, however, the frequency of the use of letrozole was significantly higher (p &amp;lt; 0.01) and that of LHRH-agonist short protocol was significantly less (p &amp;lt; 0.05) in the management of breast cancer patients than in the practice of non-cancer women. 70% of the reproductive specialists responded that they were anxious in treating YBC patients. Concerns for greater or unknown risk of disease recurrence (66%), insufficient knowledge about breast cancer (47%), and lack of patient's spouse/partner (24%) were identified as major barriers in supporting FP for YBC patients. Conclusion Reproductive specialists recognize the needs of FP in YBC patients and are willing to participate and support care for YBC. Affiliation of reproductive specialists was related to positive attitude towards to egg preservation. Various concerns regarding FP among reproductive specialists indicate the need for evidence that supports the safety of FP for YBC patients and guidelines that facilitate the practice and communication of oncologists and reproductive specialists. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-11-02.
Abstract 1761: Class I HDAC expression patterns in gastroenteropancreatic neuroendocrine tumors
Authors: Silvia Darb-Esfahani, Anja Rieger, Marianne Pavel, Atsuko Kasajima, Hironobu Sasano, Manfred Dietel, Carsten Denkert, Bertram Wiedenmann, Wilko Weichert
Journal: Cancer Research (2010)

Abstract Aims Inhibition of histone deacetylases (HDACs) has been shown to have antiproliferative and proapoptotic effects on gastrointestinal neuroendocrine tumor cells in vitro. While several HDAC inhibitors have entered clinical trials as antineoplastic agents in various tumor entities, information on the expression of HDACs in gastroenteropancreatic neuroendocrine tumors (GEP-NET) in vivo is still lacking. Methods We investigated expression of class I HDAC1, HDAC2 and HDAC3 in a large cohort of neuroendocrine tumors by immunohistochemistry and correlated our findings with clinicopathologic variables, proliferative activity and patient prognosis. Results While 58 (59.2%) out of 98 neuroendocrine foregut and midgut tumors did not display any nuclear expression of HDAC1, HDAC2 or HDAC3, 38 (38.8%) were partially positive, i.e. showed nuclear staining for at least one of the three HDAC isoforms. Only 2 (2.0%) tumors were positive for all of the three HDACs. Nuclear expression of HDAC isoforms correlated strongly (p&amp;lt;0.006) with each other and also correlated with proliferative capacity as determined by expression of Ki67 (p=0.003). Consequently, expression of HDAC1 in foregut tumors was correlated with grading (p=0.009) and a similar tendency was seen for HDAC2 (p=0.077). No correlation was seen between HDAC expression in primary tumors and tumor stage, nodal status or state of metastasis. However, HDAC expression was lower in nodal foregut and midgut lesions when compared to the corresponding primary tumors (p&amp;lt;0.023). HDAC expression was not associated with disease specific survival in stage IV midgut tumors. Conclusion Our observation of a tight association of HDAC positivity and proliferative activity in GEP-NETs mirror the fact that overexpression of HDACs promote cancer cell growth in these neoplasms in vivo. We additionaly hypothesize that differences in HDAC expression might predict response to HDAC inhibitors which should be taken into account when future clinical trials with these substances are being planned. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1761.
Amplification of LPS and LTA induced cytokine synthesis in NSCLC/neutrophil cocultures
Authors: K. Hattar, D. Heygster, B. Eul, A. Banat, L. Fink, C. Draing, W. Seeger, F. Grimminger, U. Sibelius, U. Grandel
Journal: Journal of Clinical Oncology (2008)

22198 Background: Proinflammatory cytokines are centrally involved in tumor progression and survival in NSCLC patients and both the presence of infiltrating neutrophils and bacterial infection is associated with a poor prognosis. Against this background, we investigated the effect of the bacterial cell wall components LPS and LTA on IL-6 and IL-8 synthesis in the NSCLC line A549 and in A549/neutrophil cocultures. Methods: Neutrophils were co-cultured with A549 cells in vitro and cytokine transcription and synthesis was analyzed by RT-PCR and ELISA. Results: LPS and LTA induced a dose-and time dependent release of IL-8 from A549 cells, whereas IL-6 could not be detected. Interestingly, in A549/neutrophil co-cultures, IL-8 synthesis was massively amplified when compared to single cell stimulation and marked IL-6 release was induced in the co-culture model. Neutrophils were identified as the main cellular source of the amplified cytokine generation, as enhanced cytokine mRNA transcription was detected in this cell type and not in A549 cells in the co-culture system. Experiments performed in transwells indicated that the amplification of cytokine generation was not caused by direct cell-to-cell contact, but mediated by soluble factors. Inhibition of TNF-alpha bioactivity by neutralizing antibodies blocked the enhanced cytokine generation by 50% and interference with 5-LO-metabolism was equally effective. Amplification of pathogen-induced cytokine secretion could be reproduced when the small cell lung cancer cell line HL69 was co-cultured with neutrophils. Conclusions: The interaction between bacterial pathogens, neutrophils and tumor cells may be important for the effective induction of proinflammatory and angiogenic cytokines in vivo. No significant financial relationships to disclose.
Percival's Medical Ethics.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0787 Influence of digital ulcer healing on disability and daily activity limitations in systemic sclerosis
Authors: A. Berezne, R. Seror, G. Bussone, S. Morell-Dubois, L. Guillevin, L. Mouthon
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To evaluate the impact of digital ulcer (DU) healing on disability and daily activity limitations in systemic sclerosis (SSc). <h3>Methods</h3> From January 2008 and June 2009, we prospectively evaluated, 189 SSc patients for DU history, disability, employment and occupational status during meetings of the French SSc patient association (n=86, 45.5%) or during hospitalization (n=103, 54.5%)<sup>1</sup>. Among the 60 patients with at least one active DU at baseline, 40 patients were followed longitudinally over 6±3 months. Patients were evaluated for DU history, global and hand disability, Health-related quality of life (HRQOL), daily activity limitation and employment status <h3>Results</h3> The median [IQR] age was 57.5 [43.5-68] years and the median [IQR] disease duration was 8.3 [3-16.5] years at the time of evaluation. Twenty-to (55%) patients had diffuse SSc and 34 (85%) were female. At baseline, a mean of 2.9±2.8 DU per patient was reported. Thirty-tree (82.5%) patients had ischemic UD, 7 (17.5%) patients had ≥1 DU associated with calcinosis, and 13 (32.5%) patients had mechanical DU proximal to the fingertip. Thirteen (32.5%) patients had ≥4 DU at baseline. Among the 40 patients, 16 (40%) patients showed complete ulcer healing within follow-up period. DU associated with calcinosis heal less than other (p=0.029). Comparison between healed and no-healed DU patients shows a improvement of hand disability reflected by decreased of the Cochin Hand Function score (p=0.05)) and a trend toward for HAQ subindex for dressing (p=0.056). Concerning HRQOL, there were no difference for MCS and PCS scores of SF-36 but significant improvement of Bodily Pain (p=0.0341) and Physical Role (p=0.045) in healed patients. The absence of healing was associated with decreased work productivity (p=0.047) and with no statistically significant decreased performance in ADL (p=0.154). Patients who had seak leave at the time of active DU are more likely to heal (p=0.04). New DU developed in 15 (37.5%) patients during follow-up. In multivariate analysis, diffuse form identified as independent risk factors for new digital ulcers (p=0.013). <h3>Conclusions</h3> We have been previously shown the impact of DU on global and hand disability with significant impact on ADL and work disability. DU Healing leads to an improvement in hand function. Putting off work could promote healing <h3>References</h3> Bérezné A et al. Arhtritis Care and Research 2011; 63(2):277-285 <h3>Disclosure of Interest</h3> None Declared
Reactivation of Unstable Angina after the Discontinuation of Heparin
Authors: Pierre Théroux, David Waters, Jules Lam, Martin Juneau, John McCans
Journal: New England Journal of Medicine (1992)

Heparin is an effective, widely used treatment for unstable angina. Among patients enrolled in a double-blind, randomized, placebo-controlled trial comparing intravenous heparin, aspirin, both treatments, and neither during the acute phase of unstable angina, we encountered patients in whom unstable angina was reactivated after heparin was discontinued.
Linezolid for XDR-TB — Final Study Outcomes
Authors: Myungsun Lee, Sang Nae Cho, Clifton E Barry, Taeksun Song, Youngran Kim, Ina Jeong
Journal: New England Journal of Medicine (2015)

Treatment of extensively drug-resistant mycobacteria tuberculosis is a growing global challenge. In this report, the durability of linezolid as an adjunctive XDR-TB treatment is presented.
Tc-99m MDP Uptake in Stage D Adenocarcinoma of the Colon
Authors: D A Dowe, T A Johnston, T L Showers, J F Kasper, A J Salzman
Journal: Clinical Nuclear Medicine (1998)

A 65-year-old woman was seen for left upper quadrant pain. Radiographs of the chest and abdomen were normal. A Tc-99m MDP whole-body bone scan revealed a ring-shaped area of uptake in the anterior aspect of the left upper quadrant and a faint area of increased uptake in the posterior aspect of the right upper quadrant. A CT of the abdomen revealed a mass in the proximal descending colon with metastases to the liver. Endoscopic biopsy proved this to be adenocarcinoma of the colon.
AB0681 Bisphenol A Levels in Patients with Ankylosing Spondylitis and Its Correlation with Disease Activity
Authors: N. Ustun, I. Ustun, A.E. Yagiz, R. Okur, A.D. Turhanoglu, S. Sungur, C. Gokce
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Ankylosing spondilitis (AS) is a systemic chronic inflammatory disorder of unidentified etiology. Bisphenol A (BPA) which act as a protective lining on the inside of metal-based food and beverage cans, is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics such as hard plastic bottles and epoxy resins. BPA is an estrogenic endocrine disruptor that exerts an extensive variety of metabolic effects. <h3>Objectives</h3> The objective of present study was to measure serum BPA levels in patients with AS and to explore a possible link between serum BPA levels and disease activity scores. <h3>Methods</h3> A total of 50 AS patients (40 male, 10 female, mean age 41.14±11.65 years, mean body mass index 26.78±3.94 kg/m<sup>2</sup>) and 30 age-sex- and body mass index-matched healthy controls (23 male, 7 female, mean age 41.44±6.98, mean body mass index 27±3.06 kg/m<sup>2</sup>) were taken to the study. Disease activity of the AS patients was measured by Bath ankylosing spondylitis disease activity index (BASDAI). <h3>Results</h3> The median disease duration of the AS patients was 10.68±10.43 years. Forty-three patients were taking NSAID and/or DMARD. Seven patients were taking an anti-TNF agent. Serum BPA levels of the patients with AS was significantly higher than that of healthy controls (3.98±2.35 vs. 0.49±0.29; p=0.001). There was significant positive correlation between the serum BPA levels and BASDAI scores (r=0.321, p=0.025). <h3>Conclusions</h3> These data clearly show that serum BPA levels are significantly higher in patients with AS in comparison to age-sex-BMI-matched healthy controls. Furthermore, levels of BPA in AS patients were positively correlated with disease activity scores. <h3>References</h3> Ozgocmen S, Akgul O, Altay Z, et al. Expert opinion and key recommendations for the physical therapy and rehabilitation of patients with ankylosing spondylitis. International journal of rheumatic diseases 2012;15(3):229-38. Vandenberg LN, Maffini MV, Sonnenschein C, Rubin BS, Soto AM. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocrine reviews 2009;30(1):75-95. Rogers JA, Metz L, Yong VW. Review: Endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms. Molecular immunology 2013;53(4):421-30. Wells EM, Jackson LW, Koontz MB. Association between bisphenol A and waist-to-height ratio among children: National Health and Nutrition Examination Survey, 2003-2010. Annals of epidemiology 2013. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1383
Abstract P2-02-12: Utility of Targeted Sonography Using Real-Time Virtual Sonography (RVS) for Breast Lesions That Were Suspicious on MRI
Authors: S Nakano, K Fujii, K Yorozuya, M Yoshida, J Kousaka, Y Mouri, T Fukutomi, T. Ishiguchi
Journal: Cancer Research (2010)

Abstract PURPOSE : MRI-detected suspicious breast lesions that are not expected from previous MMG or sonography, are detectable initially on MRI in 48% maximum. Therefore, biopsy is required for definitive diagnosis of MRI-detected lesions. Although MRI-guided biopsy is often necessary, sonographically guided biopsy after targeted sonography is more broadly available and less time-consuming and costly. The aim of this study was to verify the utility of targeted sonography using Real-time Virtual Sonography (RVS) for the identification of MRI-detected suspicious lesions. METHOD AND MATERIALS : From 196 breast MRI examinations, all MRI-detected suspicious lesions and subsequent biopsy were identified between February 2006 and December 2009. All patients were examined using MMG, sonography, MRI and RVS that could synchronize a sonography image and the MRI cutaway images of the same site to be displayed in real time using magnetic navigation system. Following the conventional dynamic enhanced image, MRI was obtained on a 1.5-T imager in the supine position using a flexible body surface coil in order to achieve the same position as in sonography. We searched all cases for MRI-detected suspicious lesions and investigated targeted sonography with or without RVS in identifying the lesions. RESULTS : Of the 196 patients, MRI-detected suspicious lesions were detected in 55 (28%) patients. A total of 67 suspicious lesions in 55 patients comprised this analysis. Of the study lesions, 24 (36%) were malignant and 43 (64%) were benign. Overall mean lesion size was 6.7mm. A total of 46 (69%) mass lesions were identified, compared with 16 (24%) foci and 5 (7%) nonmasslike lesions. 18 (27%) lesions were detected in targeted sonography without RVS and were revealed as cancers in eight, benign lesions in 10. In contrast, 60 (90%) lesions were detected in targeted sonography with RVS and were revealed as cancers in 21, benign lesions in 39. Although seven (10%) lesions were not detected with RVS, all lesions were able to project enhanced MRI information onto a body surface correctly as we checked ultrasound form images without the use of large-scale equipment. CONCLUSION: The present results suggest that targeted sonography with RVS appears to be not time consuming technique which can identify a large part of MRI-detected suspicious lesions. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-02-12.
Abstract 3130: Targeted DNA methylation reprogrammed differentiation and tumorigenesis of mesenchymal stem cells
Authors: Yu-Wei Leu, Shu-Huei Hsiao
Journal: Cancer Research (2012)

Abstract Mesenchymal stem cells (MSCs) are multipotent stem cells that can be isolated from various sources and induced into different cell types. Although MSCs possess immune privilege and are more easily obtained, their propensity to tumorigenesis and immune responses they might bring to patients have not been fully explored. Epigenomic revolution like changes in DNA methylation and chromatin modification have been hypothesized to be critical in the determination of lineage-specific differentiation and tumorigenesis of MSCs but has not been forwardly proved. We identified the Polycomb group-governed loci in MSCs and tracked their differential methylation changes during the MSC-to-liver or MSC-to-adipocyte differentiation. These loci were also differentially methylated in breast cancer (n=93) and liver cancer (n=40). In an independent collection of liver cancer (n=100), the methylation states of these Polycomb-governed loci like Trip10, Casp8AP2, ENSA and ZNF484 were clustered together in contrast to the non-Polycomb targets like HIC1 and RassF1A. We then developed and applied a targeted DNA methylation method to methylate the Polycomb group protein-governed gene, Trip10, in MSCs which accelerated the cell fate determination of MSCs. Targeted methylation of Casp8AP2, another Polycomb group protein-governed gene, increased cellular survival and its resistance to drugs. The targeted methylation of ENSA and ZNF484 reveal the epigenomic evolution. Targeted methylation of HIC1 and RassF1A, both are tumor suppressors but not the Polycomb target genes, transformed MSCs into tumor stem cell-like cells. With this new method, we proved that DNA methylation within critical loci is sufficient to steer the cell fate of MSCs. (Supported in part by NSC 100-2320-B-194-001) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3130. doi:1538-7445.AM2012-3130