tbuckley/cabot-search huggingface dataset:
In Reply:
Authors: Daniel C. Bowers, Kevin C. Oeffinger
Journal: Journal of Clinical Oncology (2006)

THE EDITOR: Bowers et al 1 are commended for their large cohort study on the risk of stroke in long-term survivors of Hodgkin's disease.This is the first study showing an absolute increased risk of stroke in these young patients, who were not prone to atherosclerotic diseases because of their age.After a median interval of 17.5 years, these patients have an increased relative risk of stroke of 4.3 in comparison with a sibling control group.This observed increased risk is in agreement with the elevated risk of stroke we found in patients irradiated for head and neck tumors. 2 However, the interval before the onset of stroke is longer in the Hodgkin's population: 17.5 years versus 10.9 years in the head and neck population.This could possibly be explained by differences in underlying pathogenetic mechanisms.In atherosclerotic-naive patients, like in the Hodgkin's population, irradiation on the neck seems to induce atherosclerotic-like lesions of the carotid artery.In contrast, in the population of older patients with head and neck cancer, radiation therapy (RT) accelerates pre-existing atherosclerotic disease.Both processes can eventually cause stenosis of the carotid artery 3 and thromboembolisms leading to stroke, but the timing of this depends on whether the atherosclerotic process was already initiated before irradiation.In addition, increased thickness of the carotid vascular wall in the older head and neck cancer patients might sooner induce flow disturbances and shear stress, further accelerating the atherosclerotic process.The relatively low-dose of RT used in the treatment of Hodgkin's disease (median dose, 40 Gy) compared with the dose used for head and neck cancer (60 to 70 Gy) might also contribute to slower progression of the lesions.A limitation of the Bowers study is that stroke was not confirmed by a computed tomography scan.Therefore, the contribution of other causes of cerebrovascular disease, like intracranial hemorrhage, cannot be established, nor can the origin of stroke be ascertained.Hodgkin's disease patients who receive mantle irradiation are also at risk for cardiac disease, such as valvular diseases, 4 which can also result in stroke in these patients.We agree with the authors that patients who receive irradiation on the neck should be monitored, especially those patients who have an estimated long survival.However, the suggestion of interviewing patients to establish the occurrence of cerebrovascular disease is, in our view, not the most appropriate solution, because the damage has already been done by then.We suggest duplex screening of the carotid arteries as a crucial part of follow-up to identify damage before it is associated with clinical symptoms.The next step is to investigate possible intervention strategies in order to diminish these debilitating late complications in long-term survivors of cancer.
“VISA” Nanoparticles to Breast Cancer.
Authors: X. Xie, W. Deng, M. Yang, J. Tang, X. Wang, W. Wei, Z. Xie, X. Xiao, P. Liu, J. Lang, M. Hung
Journal: Cancer Research (2009)

Abstract Development of cancer gene therapy has been hampered by the fact that there are no effective cancer-specific expression vectors available, which is critical for improving therapeutic efficacy and reducing toxicity in clinics. To overcome this problem, we recently developed a safe and effective strategy fro targeting a potent pro-apoptotic gene (BikDD) to the pancreatic tumors (Xie et al. Cancer Cell, 2007). A VISA system (VP16-Gal4-WPRE integrated systemic amplifier) was engineered by using the two-step transcriptional amplification (TSTA) system and the posttranscriptional regulatory element of the woodchuck hepatitis virus (WPRE). The VISA system can boost the activity of cancer-specific promoters by an average of 600 folds compared to their basal levels. C-VISA (CCKAR-VISA) nanoparticles transcriptionally targets transgene expression effectively to pancreatic tumors in vivo. C-VISA-BikDD nanoparticles was shown to be highly effective in reducing tumor burden and increasing animal survival rate in orthotopic pancreatic cancer models which is moving into clinical trials at University of Texas M.D. Anderson Cancer Center, USA. In the current study, we identified hTERT(human telomerase reverse transcriptase), ß-cateinin, claudin-4, and FASN (fatty acid synthase) promoters as breast cancer-selective promoters, and amplified their activity to hundreds of folds greater by the “VISA” system without loss of their specificity. We further demonstrated significant antitumor activity of targeted BikDD expression driven by nanoparticles of the hTERT-VISA-BikDD vectors in Her-2-negative and -positive breast cancer cell lines and in multiple breast cancer models of living imaging by the Xenogen IVIS imaging system with limited toxicity. In addition, treatment with hTERT-VISA-BikDD nanoparticles plus lapatinib or produces evident combinational therapeutic efficacy, which is likely due to the ability of lapatinib to promote apoptosis of Her-2-overexpressing breast cancer cells. Thus, our newly developed hTERT-VISA-BikDD nanoparticles are an innovative strategy for targeted antitumor effects of both Her-2-negative and Her-2-positive breast cancer. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5159.
INCREMENTAL PROGNOSTIC VALUE OF CARDIAC MAGNETIC RESONANCE FOR THE PREOPERATIVE ASSESSMENT OF PATIENTS WITH ISOLATED SEVERE TRICUSPID REGURGITATION
Authors: Jun-Bean Park, Hyung-Kwan Kim, Ji-Hyun Jung, Yeonyee E. Yoon, Seung-Pyo Lee, Eun-Ah Park, Ho-Young Hwang, Whal Lee, Kyung-Hwan Kim, Yong-Jin Kim, Goo-Yeong Cho, Ki-Bong Kim, Dae-Won Sohn, Hyuk Ahn, Byung-Hee Oh
Journal: Journal of the American College of Cardiology (2015)
Abstract 2261: Prognostic significance of the low level microsatellite instability phenotype differs with race in colorectal adenocarcinoma
Authors: Venkat R. Katkoori, Chura Salih, Meenakshi Sthanam, Chandrakumar Shanmugam, Tom Callens, Ludwine M. Messiaen, William E. Grizzle, Harvey L. Bumpers, George Birdsong, Upender Manne
Journal: Cancer Research (2011)

Abstract Purpose: Several studies have examined the prognostic value of microsatellite instability (low, MSI-L, and high, MSI-H) phenotypes in colorectal adenocarcinomas (CRCs), but none have specifically considered patient race/ethnicity to assess the value of MSI-L. Therefore, this study assessed the prognostic value of the MSI-L phenotype in African-American and non-Hispanic Caucasian (NHCA) CRC patients separately. Experimental Design: CRCs from 276 African-Americans and 377 NHCAs, collected at the hospitals of the University of Alabama at Birmingham and Morehouse School of Medicine, were assessed for microsatellite instability and p53 mutational status (exons 4 through 9). MSI was assessed at 4 CA-dinucleotide MS loci (Mfd 27, Mfd 41, Mfd 47, and Mfd 57) and 2 poly-A repeats (BAT25, BAT26). Samples were considered MSI-H if at least 2 loci showed instability and MSI-L (low) if only 1 marker was unstable. The phenotypes were correlated with clinicopathologic features and patient survival by use of the χ2 test and univariate Kaplan-Meier analyses, respectively. Results: The incidence of the MSI-L phenotype was higher in African-American patients (49 of 276, 18%) compared to NHCA patients (27 of 377, 7%). In contrast, the frequency of the microsatellite stable (MSS) phenotype was higher in CRCs of NHCAs (72%) than in CRCs of African-Americans (56%). In addition, the incidence of microsatellite instability-high (MSI-H) phenotype was similar in African-Americans (26%) and NHCAs (21%). Presence of the MSI-L phenotype significantly correlated with a higher incidence of missense p53 mutations (64%) and high-grade tumors (31%) and with advanced stages (III and IV) (67%) of CRCs in NHCAs. Such associations, however, were not found in African-American patients. For NHCA patients, CRCs with the MSI-L phenotype had significantly higher mortality (log-rank p=0.044) as compared to MSS or MSI-H. In contrast, for African-American patients, the MSI-L phenotype was associated with a better prognosis (log-rank p=0.043) compared to the MSS or MSI-H phenotypes. Conclusions: These findings suggest that CRC with the MSI-L phenotype is associated with p53 mutations, high-grade tumors, and advanced tumor stage, and with short survival of NHCAs but not African-Americans. This work was supported by grants from the NCI/NIH (2U54-CA118948-03, R01-CA98932, and R03-CA139629). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2261. doi:10.1158/1538-7445.AM2011-2261
Bone Marrow Imaging of Bone Marrow Transplanted Multiple Myeloma Patients
Authors: BRITA ÅGREN, ULF RUDBERG, KLAS MÅRE, PETER ASPELIN
Journal: Clinical Nuclear Medicine (1997)

Eighteen bone marrow transplanted multiple myeloma patients had imaging studies on 24 occasions with radiography as well as bone and bone marrow scintigraphy within 2 months. Twelve of the radionuclide bone marrow studies were performed with Tc-99m human serum albumin colloid and 12 were performed with a Tc-99m tagged monoclonal antigranulocyte antibody. The total detection rate of bone marrow lesions increased by 5% when the findings on bone marrow scintigraphy were combined with the findings and at radiography bone scintigraphy. For lesions in the spine and sacrum, the increase was 25% and 33% respectively, including patients with focal radiotherapy. Peripheral red bone marrow expansion was noted in 17 patients. In a comparison of Mab and Tc-99m HSA colloid imaging, Mab resulted in a higher bone marrow to soft tissue uptake and to a much smaller part of the skeleton being obscured by liver and spleen uptake. It is concluded that bone marrow imaging is valuable for showing red bone marrow distribution. It thereby shows possible sites for malignant lesions; it also shows that Mab imaging is superior to Tc-99m HSA colloid imaging in bone marrow transplanted multiple myeloma patients.
Diagnosis of Perioperative Myocardial Infarction with Measurement of Cardiac Troponin I
Authors: Jesse E. Adams, Gregorio A. Sicard, Brent T. Allen, Keith H. Bridwell, Lawrence G. Lenke, Victor G. Davila-Roman, Geza S. Bodor, Jack H. Ladenson, Allan S. Jaffe
Journal: New England Journal of Medicine (1994)

Perioperative myocardial infarction is the most common cause of morbidity and mortality in patients who have had noncardiac surgery, but its diagnosis can be difficult. The present study was designed to determine whether the measurement of serum levels of cardiac troponin I, a highly sensitive and specific marker for cardiac injury, would help establish the diagnosis of myocardial infarction.
Support Among the Dissenting Voices
Authors: K. Smigel
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Support Among the Dissenting Voices Get access Kara Smigel Kara Smigel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 22, 18 November 1992, Page 1693, https://doi.org/10.1093/jnci/84.22.1693 Published: 18 November 1992
Abstract 4083: Increased DNA methyltransferase activity and DNA methylation following epidermal growth factor stimulation in ovarian cancer cells
Authors: Sabrina L. Samudio-Ruiz, Laurie G. Hudson
Journal: Cancer Research (2012)

Abstract Ovarian cancer progression is correlated with accumulation of aberrant CpG island methylation. In patients with ovarian cancer, ascites fluid builds up and contains abundant levels of Epidermal-Growth-Factor-Receptor (EGFR) activators. This fosters a tumor microenvironment of constant EGFR activation. Signaling pathways downstream of EGFR, such as RAS, regulate DNA methylation and expression of DNA methyltransferases. We hypothesized that mimicking this microenvironment of chronic EGFR activation in culture could alter DNA methylation or expression of DNA methyltransferases in ovarian cancer cells. We found evidence that EGFR activation increased DNA methyltransferase activity by ∼3 fold acutely and by ∼7 fold following long term EGFR activation. Furthermore, this increase in activity was dependent on continued EGFR activity and resulted in a 50% increase in global DNA methylation. We also found that constitutive EGFR activation can decrease expression of DNMT3A. However, this decrease does not explain the observed increases in DNMT activity or methylation, thus future experiments will focus on a potential mechanism that mediates these EGF induced alterations to DNMT activity and DNA methylation. The data support a role for EGFR in the process of DNA methylation and accumulation during ovarian cancer progression; thus, suggesting that epigenetic therapy, used in combination with conventional chemotherapy, may be beneficial at preventing cancer progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4083. doi:1538-7445.AM2012-4083
Cerebrospinal Biomarkers in Alzheimer Disease—Potential Roles as Markers of Prognosis and Neuroplasticity
Authors: Steven T. DeKosky, Todd Golde
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
SAT0115 Upper/small joints are emphasized in new ACR/EULAR remission criteria, while physicians have respect for large joints: A nationwide study based on the ninja (national database of rheumatic diseases by IR-net in japan) 2010:
Authors: S. Nishiyama, K. Ohashi, T. Aita, Y. Yoshinaga, S. Miyawaki, S. Tohma
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To identify effective predictors of remission in patients with rheumatoid arthritis (RA). <h3>Methods</h3> Total Joint indices (TJI) of upper/large, upper/small, lower/large, and lower/small regions were calculated as the sum of tender and swollen joint counts divided by the number of evaluable joints in each region of interest (1). Data of 369 RA patients receiving MTX from Kurashiki Medical Center were applied to obtain logistic models for predicting the probability of remission. These models were validated using data of 6202 patients from <i>NinJa</i> 2010, an annually updated nationwide database in Japan. <h3>Results</h3> TJI of all the regions were effective predictors for new ACR/EULAR (A/E), SDAI, CDAI, boolean and DAS28 remission definitions (table 1). Larger odds ratio (OR) means higher probability of remission. Upper joints, especially in upper/small were more effective predictors for A/E and SDAI remission than lower joints. OR for each region, except for upper/small region in DAS28 remission was similar to that in A/E and SDAI remission. OR for every joint region in CDAI remission was relatively high and upper/larger region was the highest of all. OR for upper/large region in boolean remission was relatively low compared to other remission definitions. Overall percentage of correct classification of <i>NinJa</i> data were 83.9% for A/E, 85.3% for SDAI, 85.7% for CDAI, 80.7% for boolean, and 78.0% for DAS28 remission. Data satisfied A/E were classified into 2 groups: physician global assessment ≤1cm and &gt;1cm. The rates of positive TJI in upper/large and lower/large regions were 18.5 and 19.7% for &gt;1cm group, respectively, and were significantly higher than those for ≤1cm group (10.9 and 9.5%, respectively). <h3>Conclusions</h3> Upper/small joints were emphasized in A/E and SDAI remission compared to DAS28 remission. Physicians had respect for affected large joints in patients with A/E remission. <h3>References</h3> Nishiyama S, et al, Proposing a method of regional assessment and a novel outcome measure in rheumatoid arthritis. Rheumatol Int. DOI 10.1007/s00296-011-2058-9, 2011 <h3>Disclosure of Interest</h3> None Declared
CORRELACIÓN CLÍNICO-ENDOSCÓPICA DE LA HETEROTOPIA GÁSTRICA EN ESÓFAGO
Authors: LR Gotuzzo Altez, MA Huertas Velasco, E Martin Arranz, M Jaquotot Herranz, R Barba Martin, G Payeras Llodrá
Journal: Endoscopy (2013)

Introducción: La heterotopia gástrica en esófago cervical (HGEC), o “inlet patch”, consiste en presencia de mucosa gástrica a este nivel. Por su localización postcricoidea suelen ser lesiones infradiagnosticadas y su relación con el reflujo gastroesofágico (RGE) no está bien establecida. Objetivo: Valorar el grado de correlación existente entre los síntomas clínicos y la HGEC. Material y Método: Estudio retrospectivo y descriptivo de los pacientes diagnosticados de HGEC durante las gastroscopias realizadas en el Hospital Universitario Rey Juan Carlos desde abril del 2012 hasta junio del 2013. Resultados: Se realizaron 2000 gastroscopias diagnosticándose 19 casos de HGEC: 10 casos en mujeres (52,6%) y 9 en varones (47,4%). La media de la edad fue 45,26 años y mediana de 46 años. El rango de edad osciló entre 21 y 73 años. Motivos para la realización de la gastroscopia: dispepsia (31,6%), sensación de cuerpo extraño faríngeo (21,1%), síntomas de RGE (15,8%), asintomáticos (10,5%), disfagia (5,3%), y otros (15,8%). En el 52,6% los casos la lesión medía menos de 10 mm y en el resto entre 10 y 20 mm. En 9 casos (47,4%) se presentó como un islote de mucosa ectópica, en otros 9 casos con 2 islotes, y un caso con 3 islotes de mucosa ectópica. Se realizó biopsia de la mucosa ectópica en 14 casos (73,7%) confirmándose la heterotopia gástrica en el 100% de las muestras. La presencia de Helicobacter pylori en mucosa gástrica se confirmó en 10 de los 17 casos (52,6%) y sólo 3 pacientes fueron diagnosticados de esófago de Barrett (15,8%). Conclusiones: La mayoría de los pacientes con HGEC no presentaban Barrett y menos del 50% tenían síntomas de RGE, por lo que se podría concluir que el RGE no desempeña un papel importante en su etiopatogenia. Es necesario aumentar el tamaño muestral (estudios multicéntricos) para obtener Conclusiones: estadísticamente significativas.
PM-21 * A REVERSE GENETIC SCREEN FOR DRIVERS OF GBM
Authors: B. R. Tschida, A. R. Lowy, C. A. Marek, T. Ringstrom, T. C. Beadnell, R. L. Klank, D. J. Odde, H. B. Clark, S. M. Wiesner, D. A. Largaespada
Journal: Neuro-Oncology (2014)

INTRODUCTION: Glioblastoma multiforme (GBM) is the most malignant and most common primary brain tumor. There is no curative chemotherapeutic regimen for GBM, and its invasiveness greatly limits efficacy of surgery and radiation therapy. Molecular drivers of GBM growth, maintenance, and invasion need to be identified to develop effective therapies. METHODS: We selected 50 genes found to be overexpressed in a high proportion of GBM in comprehensive sequencing and gene expression analysis studies by The Cancer Genome Atlas (TCGA) Research Network and the Howard Hughes Medical Institute (Parsons et al 2008). We hypothesized a common subset of these genes directly promote tumor initiation or maintenance downstream of initiating genetic alterations, and screened them in vivo. A cDNA for each of these genes and SV40 large T antigen (TAg) was cloned into a separate Sleeping Beauty (SB) transposon plasmid. The cDNA delivery plasmids were stereotactically injected into the lateral ventricles of neonatal mice in batches of 9, along with the TAg vector to facilitate tumor formation and a SB transposase expression plasmid containing a firefly luciferase transposon. We monitored tumor development by luciferase imaging. RESULTS: Tumors developed in a subset of mice, the majority of which were highly infiltrative with vascular proliferation and histologically resembled grade 3 glioma. Injection of the HIF1a cDNA was associated with infiltrative tumors in our model and has been implicated in glioma infiltration previously. UBE2C, CCNE2, and EZH2 cDNAs were associated with reduced tumor latency and may drive glioma cell proliferation. We are testing these cDNAs individually in vivo and in vitro to confirm their roles in driving infiltration and proliferation. CONCLUSIONS: We used a SB transposon-based reverse genetic mouse model to screen for common GBM drivers. Of the 50 genes screened, we identified 4 strong candidates which may drive tumor cell proliferation and infiltration.
TCT-661 Vascular Brachytherapy versus Drug-Eluting Stents in the Treatment of In-Stent Restenosis: a Meta-Analysis of Long Term Outcomes
Authors: Rhanderson N. Cardoso, Alexandre M. Benjo, Tyrone Collins, Daniel Garcia, Francisco Y. Macedo, Georges EL-Hayek, Carlos Zamora, Emad Aziz, James S. Jenkins
Journal: Journal of the American College of Cardiology (2014)
Silastic Intravenous Catheter
Authors: Richard D. Stewart, Charles A. Sanislow
Journal: New England Journal of Medicine (1961)

A NEED exists for an intravenous catheter that possesses better properties than the currently available polyethylene catheter. Ideally, a catheter for intravenous infusion should have the following properties: tissue inertness, so as not to evoke a foreign-body response or promote blood coagulation; the softness and flexibility of a vein, so as not to produce mechanical trauma with limb motion while residing within the vein; strength and durability; ease of insertion and maintenance; long storage life; and low cost. Because silastic tubing potentially possessed the properties listed above,1 2 3 4 5 6 7 8 silastic intravenous catheters were obtained through the Dow Corning . . .
Pedunculated cavernous hemangioma mimicking inflammatory fibroid polyp in a patient with ulcerative colitis
Authors: K. Ueda, H. Nakase, H. Yaku, Y. Honzawa, T. Chiba
Journal: Endoscopy (2010)

A-29-year-old man with steroid-dependent ulcerative colitis had been treated with tacrolimus therapy. He underwent colonoscopy to evaluate the therapeutic effect of the tacrolimus therapy. Endoscopic examination revealed complete mucosal healing throughout the entire colon. However, a pedunculated polyp, 10 mm in size, which exhibited superficial areas of ulceration on its surface, was detected at the sigmoid colon ([Fig. 1]). This endoscopic finding was suggestive of inflammatory fibroid polyp (IFP). We considered this polyp to be the source of hematochezia and performed snare polypectomy. Histologic examination revealed a polyp with erosion and granulation at the surface and, in the submucosal area, proliferation of dilated blood vessels and infiltration of mononuclear cells ([Fig. 2]). Spindle cells positive for CD34 were not observed. This polyp was diagnosed as a pedunculated cavernous hemangioma.