tbuckley/cabot-search huggingface dataset:
Abstract 18978: Resting Pressure Gradient (iFG) Instantaneous Wave-free ratio (iFR) for Non-culprit Stenosis Evaluation in Patients with Acute Coronary Syndromes. Preliminary Data from the FORECAST Study
Authors: Ciro Indolfi, Alberto Polimeni, Annalisa Mongiardo, Carmen Spaccarotella, Sabato Sorrentino, Antonio Curcio, Gianluca Caiazzo, Daniele Torella, Salvatore De Rosa
Journal: Circulation (2012)

Background: The assessment of non-culprit stenoses is an important issue in ACS. Adenosine administration is currently required for functional evaluation of stenosis severity using the fractional flow reserve (FFR). An alternative adenosine-independent index of coronary stenosis, the instantaneous wave-free ratio (iFR), was recently introduced. Objective: Aim of the present study was to evaluate the trans-stenotic instantaneous wave-free pressure gradient (iFG), the instantaneous wave-free ratio (iFR) and the fractional flow reserve (FFR) in ACS patients. Methods: Intracoronary diastolic pressure was measured proximal and distal to the stenosis during the wave-free period with a pressure wire (Certus, St. Jude, USA) at baseline and upon iv adenosine administration (140 ug/kg/min). The data were acquired with a PowerLab (AD Instruments, USA) and analyzed with a LabChart 7. Results: A total of 71 stenoses were evaluated in the present study. iFR showed a correlation with FFR (r=0.61, p&lt;0.001), while a proportional error was documented with the Bland-Altman analysis. At multivariate analysis, the localization of the evaluated stenosis within the coronary tree influenced the correlation of iFR with FFR (p=0.03). ROC analysis showed a promising diagnostic efficiency for detection of significant coronary stenosis with iFR (AUC=0.936; p&lt;0.001) or iFG (AUC=0.944; p&lt;0.001). Conclusions: The instant wave-free ratio (iFR) and the resting distal-to-proximal pressure gradient measured during the wave-free period (iFG) showed a good diagnostic performance for the assessment of non-culprit lesions in ACS, representing a promising and adenosine-independent alternative to standard fractional flow reserve (FFR).
Spatiotemporal variation of mammalian protein complex stoichiometries
Authors: Alessandro Ori, Murat Iskar, Katarzyna Buczak, Panagiotis Kastritis, Luca Parca, Amparo Andrés-Pons, Stephan Singer, Peer Bork, Martin Beck
Journal: Genome biology (2016)

Recent large-scale studies revealed cell-type specific proteomes. However, protein complexes, the basic functional modules of a cell, have been so far mostly considered as static entities with well-defined structures. The co-expression of their members has not been systematically charted at the protein level. We used measurements of protein abundance across 11 cell types and five temporal states to analyze the co-expression and the compositional variations of 182 well-characterized protein complexes. We show that although the abundance of protein complex members is generally co-regulated, a considerable fraction of all investigated protein complexes is subject to stoichiometric changes. Compositional variation is most frequently seen in complexes involved in chromatin regulation and cellular transport, and often involves paralog switching as a mechanism for the regulation of complex stoichiometry. We demonstrate that compositional signatures of variable protein complexes have discriminative power beyond individual cell states and can distinguish cancer cells from healthy ones. Our work demonstrates that many protein complexes contain variable members that cause distinct stoichometries and functionally fine-tune complexes spatiotemporally. Only a fraction of these compositional variations is mediated by changes in transcription and other mechanisms regulating protein abundance contribute to determine protein complex stoichiometries. Our work highlights the superior power of proteome profiles to study protein complexes and their variants across cell states.
Treatment and Long-term Risks for Patients With a Diagnosis of Ductal Carcinoma In Situ
Authors: Abram Recht, Eileen Rakovitch, Lawrence J. Solin
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Exercise and Pharmacological Treatment of Depressive Symptoms in Patients With Coronary Heart Disease
Authors: James A. Blumenthal, Andrew Sherwood, Michael A. Babyak, Lana L. Watkins, Patrick J. Smith, Benson M. Hoffman, C. Virginia F. O'Hayer, Stephanie Mabe, Julie Johnson, P. Murali Doraiswamy, Wei Jiang, Douglas D. Schocken, Alan L. Hinderliter
Journal: Journal of the American College of Cardiology (2012)
Chimney stove intervention – ready for scale up? CON
Authors: Kevin Mortimer
Journal: Thorax (2016)

The Global Burden of Disease Study estimated that in 2010 there were 6.3, 3.5 and 3.2 million deaths attributable to tobacco smoking, household air pollution from solid fuels and ambient particulate matter pollution, respectively.1 The inhalation of polluted air is the leading risk factor for death and disability globally.

The adverse effects of these three categories of air pollution impact most severely on the vulnerable and poor. This is especially true for household air pollution from solid fuels, which almost exclusively affects the poor in the world's poorest countries.2

Around the world approximately three billion people use dirty burning solid fuels like animal dung, crop residues and wood for their day-to-day household energy needs. These fuels are typically burned in open fires for cooking, heating and lighting in or near the home environment. When burned in this way they emit substantial quantities of partial products of combustion like black carbon and carbon monoxide which are harmful to health. The 3.5 million deaths attributable to household air pollution each year are mainly from cardiovascular disease and COPD in adults and pneumonia in young children.3 ,4

In Thorax , Heinzerling et al 5 describe the CRECER study, a prospective cohort study of the effects of woodsmoke exposure on children in Guatemala in relation to the introduction of a chimney stove intervention. CRECER …
Risk of Cerebral Venous Thrombosis in Obese Women
Authors: Susanna M. Zuurbier, Marcel Arnold, Saskia Middeldorp, Anne Broeg-Morvay, Suzanne M. Silvis, Mirjam R. Heldner, Julia Meisterernst, Banne Nemeth, Eva R. Meulendijks, Jan Stam, Suzanne C. Cannegieter, Jonathan M. Coutinho
Journal: JAMA Neurology (2016)

Obesity is a risk factor for deep vein thrombosis of the leg and pulmonary embolism. To date, however, whether obesity is associated with adult cerebral venous thrombosis (CVT) has not been assessed.To assess whether obesity is a risk factor for CVT.A case-control study was performed in consecutive adult patients with CVT admitted from July 1, 2006 (Amsterdam), and October 1, 2009 (Berne), through December 31, 2014, to the Academic Medical Center in Amsterdam, the Netherlands, or Inselspital University Hospital in Berne, Switzerland. The control group was composed of individuals from the control population of the Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis study, which was a large Dutch case-control study performed from March 1, 1999, to September 31, 2004, and in which risk factors for deep vein thrombosis and pulmonary embolism were assessed. Data analysis was performed from January 2 to July 12, 2015.Obesity was determined by body mass index (BMI). A BMI of 30 or greater was considered to indicate obesity, and a BMI of 25 to 29.99 was considered to indicate overweight. A multiple imputation procedure was used for missing data. We adjusted for sex, age, history of cancer, ethnicity, smoking status, and oral contraceptive use. Individuals with normal weight (BMI <25) were the reference category.The study included 186 cases and 6134 controls. Cases were younger (median age, 40 vs 48 years), more often female (133 [71.5%] vs 3220 [52.5%]), more often used oral contraceptives (97 [72.9%] vs 758 [23.5%] of women), and more frequently had a history of cancer (17 [9.1%] vs 235 [3.8%]) compared with controls. Obesity (BMI ≥30) was associated with an increased risk of CVT (adjusted odds ratio [OR], 2.63; 95% CI, 1.53-4.54). Stratification by sex revealed a strong association between CVT and obesity in women (adjusted OR, 3.50; 95% CI, 2.00-6.14) but not in men (adjusted OR, 1.16; 95% CI, 0.25-5.30). Further stratification revealed that, in women who used oral contraceptives, overweight and obesity were associated with an increased risk of CVT in a dose-dependent manner (BMI 25.0-29.9: adjusted OR, 11.87; 95% CI, 5.94-23.74; BMI ≥30: adjusted OR, 29.26; 95% CI, 13.47-63.60). No association was found in women who did not use oral contraceptives.Obesity is a strong risk factor for CVT in women who use oral contraceptives.
Human Rabies — Virginia, 2017
Authors: Julia Murphy, Costi D. Sifri, Rhonda Pruitt, Marcia Hornberger, Denise Bonds, Jesse Blanton, James Ellison, R. Elaine Cagnina, Kyle B. Enfield, Miriam Shiferaw, Crystal Gigante, Edgar Condori, Karen Gruszynski, Ryan M. Wallace
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

On May 9, 2017, the Virginia Department of Health was notified regarding a patient with suspected rabies. The patient had sustained a dog bite 6 weeks before symptom onset while traveling in India. On May 11, CDC confirmed that the patient was infected with a rabies virus that circulates in dogs in India. Despite aggressive treatment, the patient died, becoming the ninth person exposed to rabies abroad who has died from rabies in the United States since 2008. A total of 250 health care workers were assessed for exposure to the patient, 72 (29%) of whom were advised to initiate postexposure prophylaxis (PEP). The total pharmaceutical cost for PEP (rabies immunoglobulin and rabies vaccine) was approximately $235,000. International travelers should consider a pretravel consultation with travel health specialists; rabies preexposure prophylaxis is warranted for travelers who will be in rabies endemic countries for long durations, in remote areas, or who plan activities that might put them at risk for a rabies exposures.
Retrospective analysis of surgical resection after induction chemotherapy for patients with T4b squamous cell head and neck cancer
Authors: F. Rivera, M. E. Vega-Villegas, C. López, M. F. López-Brea, J. Rodriguez-Iglesias, A. Rubio, A. del Valle, M. F. García- Reija, B. García-Montesinos, J. Sanz-Ortiz
Journal: Journal of Clinical Oncology (2007)

16517 Background: Although standard treatment of patients with T4b Squamous Cell Head and Neck Cancer (T4b-SCHNC) for the last decade has been concomitant Chemo-Radiotherapy (CT-RT), recent Phase III trials with new Induction Chemotherapy (IC) regimens suggest that IC could also play a role in this setting. The value of adding surgery of the residual mass after IC and before RT if the resection is technically feasible is not clear in this context. Methods: We present the results of a retrospective analysis focused on this topic. Results: Between 1984 and 2001, 113 patients (pts) with T4b-SCHNC were treated at our institution with platin-based IC. Four pts dead during IC and 57 pts achieved a complete or a &gt;90% partial response at primary and proceeded to definitive RT (or concomitant CT/RT). In the other 52 pts, surgical resection was reconsidered after IC and before RT and in 13 of them this surgery was performed: in 7 pts (6 had PR and 1 minor response after IC) the resection was R1, all these patients had loco-regional progression (2 of them also developed systemic metastases) and median OS after surgery was 21 months with no patient alive at 48 months; In the other 6 pts (3 had a PR and 3 had minor response after IC) an R0 resection was performed: 3 of these pts had loco-regional relapses (1 of them also developed systemic metastases) and the other 3 pts remain alive and disease free 56, 62 and 72 months after surgery. OS of the 52 pts that achieved less than a 90% partial response at primary with IC, was equivalent for those no resected after IC pts and for R1 resected pts (actuarial 5 year OS 8% vs 0%, lrk, p=0,74) but a statistically significant improvement in OS was observed when an R0 resection was obtained after IC (actuarial 5 years OS 50%, lrk, p=0,02).Conclusions: R0 resections after IC and before RT could improve OS in pts with T4b-SCHNC that obtain less than a 90%PR at primary after IC. R1 resection appears to have no value in this setting. This approach should be studied in properly designed prospective clinical trials. No significant financial relationships to disclose.
Abstract 19840: Transcatheter Left Gastric Artery Therapy for Treating Obesity
Authors: Nicholas Kipshidze, Hosrt Sievert, Stefan Bertog, Akaki Archvadze, Martin B Leon
Journal: Circulation (2015)

Introduction: Obesity is associated with adverse cardiovascular and metabolic conditions. Dietary, medical or surgical weight loss strategies are frequently unsuccessful and/or accompanied by risks. Ghrelin, produced in the gastric fundus, stimulates food intake. Catheter-directed left Gastric Artery Embolization (GAE) causes a reduction in plasma ghrelin levels and weight loss in an animal model. The effect of GAE on ghrelin levels and weight in humans is unknown. Aim: Purpose of this study was an initial assessment of safety and efficacy of GAE in humans. Methods: Five obese patients underwent left GAE with BeadBlock Embolic Bead 300-500μm microspheres (Biocompatibles UK Limited, UK). Esophagogastroscopy was performed in all patients before and after GAE and at 1-week follow-up to assess for gastritis or ulcers after the procedure. Weight and fasting plasma ghrelin levels were obtained at baseline and 1-, 3-, 6- and 12-month follow-up. Results: The procedure was successful in all patients with no periprocedural complications. Three of 5 patients complained about mild, transient postprocedural epigastric pain. However, gastroscopy did not reveal any abnormalities. Significant progressive weight loss accompanied by reductions in plasma ghrelin levels was observed in all patients at all follow-up: mean initial weight (128.12±24.4kg) decreased to 106±21kg (p&lt;0.001) at 20-24-month follow-up and plasma ghrelin levels (initially 473±189) decreased by 29%, 36%, 19% and 21% at 1-, 3-, 6- and 12-month follow-up (p&lt;0.05). Conclusions: Percutaneous left gastric artery embolization with embolic beads as described in our study appears safe. It leads to a reduction in plasma ghrelin levels and is accompanied by a significant weight loss at intermediate term follow-up. Further studies with larger patient numbers and perhaps use of dedicated device are needed to examine the utility of this procedure and to determine the best procedural technique that allows adequate mucosal injury and ghrelin reduction while minimizing the risk of ulcer formation.
Free Paper Session : Hepatitis B ; HBV DNA Level at 6-months is the best predictor of virologic response to adefovir add-on therapy in patients with Lamivudine resistance (초)
Authors: Soo Yuck Park, Jung Woo Shin, Seok Won Jung, Bo Ryung Park, Chang Jae Kim, Kyong Won Lee, Jun Bum Eum, Byung Gyu Kim, In Du Jeong, Sung Jo Bang, Neung Hwa Park
Journal: Clinical and Molecular Hepatology (2011)
Misshapen/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation
Authors: Ming Yue, Dongjiao Luo, Shanshan Yu, Pu Liu, Qi Zhou, Mengjiao Hu, Yangyang Liu, Shuai Wang, Qian Huang, Yuxi Niu, Linrong Lu, Hu Hu
Journal: Blood (2015)
Recent advances and open challenges in hybrid brain-computer interfacing: a technological review of non-invasive human research
Authors: H. Banville, T.H. Falk
Journal: Brain-Computer Interfaces (2016)

Context. In recent years, hybrid brain-computer interfaces (hBCIs) have proven to be a promising path towards practical brain-computer interfacing. These hybrid interfaces capitalize on the concurrent recording of various physiological signals, or of the elicitation of more than one mental process, to increase the number of possible input commands and achieve more flexible and robust systems. Although hBCIs have previously been reviewed in some articles, a more recent, and complete survey of the literature is missing to lay the foundations for further research. Objective. This work aims at systematically reviewing recent articles on the topic of non-invasive hBCIs, to comprehensively identify the current trends, limitations and challenges that these studies report. Methods. Three major databases covering the fields of science and engineering were queried. From these and others sources, 55 journal articles from 2008 to November 2014 were selected and analyzed. Results. Twenty-two items were investigated to offer a complete perspective on the current state of non-invasive hBCI research in humans, covering the study rationale, experimental protocol, signal-processing methodology, and system evaluation. Based on this analysis, recommendations were formulated to direct further work in the field. Significance. We hope this review will constitute the groundwork for future hBCI studies.
Two-mAb cocktail protects macaques against the Makona variant of Ebola virus
Authors: Xiangguo Qiu, Jonathan Audet, Ming Lv, Shihua He, Gary Wong, Haiyan Wei, Longlong Luo, Lisa Fernando, Andrea Kroeker, Hugues Fausther Bovendo, Alexander Bello, Feng Li, Pei Ye, Michael Jacobs, Giuseppe Ippolito, Erica Ollmann Saphire, Shengli Bi, Beifen Shen, George F. Gao, Larry Zeitlin, Jiannan Feng, Boyan Zhang, Gary P. Kobinger
Journal: Science Translational Medicine (2016)

A two–monoclonal antibody cocktail protects nonhuman primates against Ebola virus 3 days after lethal exposure.
Herpesvirus saimiri–transformed macaque T cells are tolerated and do not cause lymphoma after autologous reinfusion
Authors: Andrea Knappe, Gisela Feldmann, Ulf Dittmer, Edgar Meinl, Thomas Nisslein, Sabine Wittmann, Kerstin Mätz-Rensing, Thomas Kirchner, Walter Bodemer, Helmut Fickenscher
Journal: Blood (2000)
Whole Exome Sequencing Identifies Somatic Mutation Patterns Of Myeloid Cells In Patients With Myeloproliferative Neoplasms Treated With Allogeneic Bone Marrow Transplantation
Authors: Jelena D. Milosevic, Elisa Rumi, Daniela Pietra, Klaudia Bagienski, Tiina Berg, Emanuela Sant'Antonio, Anna Colombo, Francesco Ripamonti, Mario Cazzola, Robert Kralovics
Journal: Blood (2013)
Treatment of Wilms tumor relapsing after initial treatment with vincristine and actinomycin D. A report from the National Wilms Tumor Study (NWTS) Group
Authors: D. M. Green, M. Malogolowkin, C. Cotton, N. Breslow, E. Perlman, J. Miser, M. Ritchey, P. Thomas, P. Grundy, G. D’Angio
Journal: Journal of Clinical Oncology (2005)

8551 NWTS - 5 was a multi-institutional clinical trial for patients less than 16 years of age at diagnosis with specific renal neoplasms who were diagnosed between August 1, 1995 and May 31, 2002. A uniform approach to the treatment of patients with relapse was employed. 72 patients who relapsed after immediate nephrectomy (stages I and II), initial chemotherapy with vincristine and actinomycin D and no radiation therapy were registered on stratum B of the NWTS-5 Relapse protocol. Four patients were not evaluable: one due to insufficient data and 3 due to major protocol violations. Among the 68 remaining patients, 5 with bilateral Wilms tumor at diagnosis, 3 who developed a contralateral relapse and 1 with persistent disease were not included in this analysis. Relapse treatment included surgical excision, when feasible, radiation therapy and alternating courses of vincristine, doxorubicin and cyclophosphamide and etoposide and cyclophosphamide. The most frequent toxicities were hematological. These results demonstrate that a significant proportion of children with Wilms tumor who relapse after initial treatment with vincristine and actinomycin D can be successfully re-treated. Author Disclosure Results by Site of Relapse Site of Relapse Number of Patients Number of Second Events 4-year EFS (%) Number of Deaths 4-year Survival (%) All 59 15 69.1 10 82.2 Operative bed lung other sites 18 2 77.8 2 88.0 Liver 1 1 0.0 0 0.0 Abdomen or pelvis other sites 6 1 66.7 0 0.0 Lung only 31 9 67.8 7 81.0 Lung and other 2 1 50.0 1 50.0 Other 1 0 - 0 - No significant financial relationships to disclose.
Resting pulmonary artery pressure of 21–24 mmHg predicts abnormal exercise haemodynamics
Authors: Edmund M.T. Lau, Laurent Godinas, Olivier Sitbon, David Montani, Laurent Savale, Xavier Jaïs, Frederic Lador, Sven Gunther, David S. Celermajer, Gérald Simonneau, Marc Humbert, Denis Chemla, Philippe Herve
Journal: European Respiratory Journal (2016)

A resting mean pulmonary artery pressure (mPAP) of 21–24 mmHg is above the upper limit of normal but does not reach criteria for the diagnosis of pulmonary hypertension (PH). We sought to determine whether an mPAP of 21–24 mmHg is associated with an increased risk of developing an abnormal pulmonary vascular response during exercise. Consecutive patients (n=290) with resting mPAP &lt;25 mmHg who underwent invasive exercise haemodynamics were analysed. Risk factors for pulmonary vascular disease or left heart disease were present in 63.4% and 43.8% of subjects. An abnormal pulmonary vascular response (or exercise PH) was defined by mPAP &gt;30 mmHg and total pulmonary vascular resistance &gt;3 WU at maximal exercise. Exercise PH occurred in 74 (86.0%) out of 86 versus 96 (47.1%) out of 204 in the mPAP of 21–24 mmHg and mPAP &lt;21 mmHg groups, respectively (OR 6.9, 95% CI: 3.6–13.6; p&lt;0.0001). Patients with mPAP of 21–24 mmHg had lower 6-min walk distance (p=0.002) and higher New York Heart Association functional class status (p=0.03). Decreasing levels of mPAP were associated with a lower prevalence of exercise PH, which occurred in 60.3%, 38.7% and 7.7% of patients with mPAP of 17–20, 13–16 and &lt;13 mmHg, respectively. In an at-risk population, a resting mPAP between 21–24 mmHg is closely associated with exercise PH together with worse functional capacity.
Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes
Authors: Boris B. Betz, Sara J. Jenks, Andrew D. Cronshaw, Douglas J. Lamont, Carolynn Cairns, Jonathan R. Manning, Jane Goddard, David J. Webb, John J. Mullins, Jeremy Hughes, Stela McLachlan, Mark W.J. Strachan, Jackie F. Price, Bryan R. Conway
Journal: Kidney International (2016)
Blaschkoid Skin Lesions in a Young Girl
Authors: Jake E. Turrentine, Katherine A. Gordon, Nnenna G. Agim
Journal: JAMA Dermatology (2016)

A young girl presented for care of skin lesions on her trunk and extremities that had been present since birth and an intermittent inflammatory reaction localized to the lesions; there was no history of developmental delay, eye abnormalities, or seizures. What is your diagnosis?