tbuckley/cabot-search huggingface dataset:
Abstract 17933: Incidence, Predictors and Clinical Course of Atrial Tachyarrhythmias in Patients with Pulmonary Hypertension
Authors: Madhu Reddy, Hemant Boolani, Suresh Sharma, Ramchandur Bakhtiani, Sowjanya Duthuluri, Namratha Reddy, Donita Atkins, Sudharani Bommana, James Vacek, Jayant Nath, Kamal Gupta, Buddhadeb Dawn, Dhanunjaya Lakkireddy
Journal: Circulation (2012)

Background: The clinical profile of atrial tachyarrhythmias (ATa) in patients with pulmonary hypertension (PHTN) is less well understood. Methods: We studied 311 patients with PHTN confirmed with r...
Identifying genetic determinants in human essential hypertension.
Authors: C R Dudley, L A Giuffra, S T Reeders
Journal: Journal of the American Society of Nephrology (1992)

Genetic factors play an important role in the pathophysiology of human essential hypertension. The remarkable success of molecular genetic techniques in identifying the basis for single gene disorders at the DNA level has encouraged investigators to apply similar techniques in an attempt to identify blood pressure genes. In contrast to single gene disorders, however, the study of blood pressure is complicated by its quantitative, complex, heterogeneous, and polygenic nature. This article examines current methods and strategies for identifying genetic determinants in human hypertension. The availability of highly polymorphic markers, the advances in quantitative trait analysis, and the mapping of blood pressure-determining genes in a polygenic rat model of hypertension suggest that molecular genetic research in human hypertension has come of age.
Effect of Growth of a Tumor on the Regulation of Water Intake
Authors: S. D. Morrison
Journal: JNCI Journal of the National Cancer Institute (1968)

The water intake of rats during growth of the Walker 256 tumor remains high in the presence of a spontaneously declining food intake. The water intake associated with food intake can be assessed by regarding the spontaneous food intake as ad libitum, and this leaves a large component of the actual water intake unaccounted for; or it can be assessed by regarding the spontaneous food intake as restricted, and this leaves a small but appreciable component unaccounted for. Rats that have recovered from the acute effects of lateral hypothalamic lesions and that no longer have the normal drinking response to food deprivation show, during tumor growth, a small component of water intake not accountable to food intake and of a size and time of occurrence comparable to the latter estimate for intact tumor bearers. The elevation in water intake induced by the tumor and not accountable to food intake appears not to depend on lateral hypothalamic mechanisms. The decline of food intake in tumor bearers may have the physiological characteristics of a food restriction.
Intrareticular Cell Multiplication of Leukemic Lymphoblasts in Thymic Tissue Cultures&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Harry Ioachim, Jacob Furth
Journal: JNCI Journal of the National Cancer Institute (1964)

Thymic lymphomas were induced in W/-Fu rats with, rat-adapted Gross passage A virus. Tissue cultures from these thymic lymphomas were studied in parallel with those of normal embryonal and adult rat thymuses and observed for 300 days. Unlike normal lymphoid cells, these cells apparently can be grown indefinitely. In postnatal normal thymus cultures, the lymphocytes disappeared after 2 to 3 weeks and a pure reticular cell growth was established. In the thymic lymphoma cultures, lymphoblasts and reticular cells grew in symbiosis. The former were predominant in the supernatant and the latter predominant in a monolayer attached to the glass. In the thymoma cultures, lymphoblasts were seen in the cytoplasm of reticular cells. Normal and atypical mitotic figures were common in lymphoblasts inside reticular cells; as many as 30 lymphoblasts were seen in the cytoplasm of some reticular cells. Morphologically, the lymphoblasts appeared to emerge from the reticular cells into the fluid medium. A small number of lymphocytes inside reticular cells was seen in a few embryonal thymus cultures but in none of the postnatal ones. The supernatant of lymphoma cultures containing floating round cells is capable of reestablishing the symbiosis of reticular cells with lymphoblasts, including the intracytoplasmic growth of lymphoblasts in reticular cells. Leukemic lymphoblasts added to cultures of postnatal normal thymus multiplied in the reticular cells. The lymphomatous lymphoblasts retained invasiveness in these symbiotic cultures, causing lymphomas that were fatal within 10 to 16 days when injected into young isologous rats.
Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma
Authors: Abhishek D. Garg, Lien Vandenberk, Carolien Koks, Tina Verschuere, Louis Boon, Stefaan W. Van Gool, Patrizia Agostinis
Journal: Science Translational Medicine (2016)

The promise of dendritic cell (DC)-based immunotherapy has been established by two decades of translational research. Of the four malignancies most targeted with clinical DC immunotherapy, high-grade glioma (HGG) has shown the highest susceptibility. HGG-induced immunosuppression is a roadblock to immunotherapy, but may be overcome by the application of T helper 1 (T(H)1) immunity-biased, next-generation, DC immunotherapy. To this end, we combined DC immunotherapy with immunogenic cell death (ICD; a modality shown to induce T(H)1 immunity) induced by hypericin-based photodynamic therapy. In an orthotopic HGG mouse model involving prophylactic/curative setups, both biologically and clinically relevant versions of ICD-based DC vaccines provided strong anti-HGG survival benefit. We found that the ability of DC vaccines to elicit HGG rejection was significantly blunted if cancer cell-associated reactive oxygen species and emanating danger signals were blocked either singly or concomitantly, showing hierarchical effect on immunogenicity, or if DCs, DC-associated MyD88 signal, or the adaptive immune system (especially CD8(+) T cells) were depleted. In a curative setting, ICD-based DC vaccines synergized with standard-of-care chemotherapy (temozolomide) to increase survival of HGG-bearing mice by ~300%, resulting in ~50% long-term survivors. Additionally, DC vaccines also induced an immunostimulatory shift in the brain immune contexture from regulatory T cells to T(H)1/cytotoxic T lymphocyte/T(H)17 cells. Analysis of the The Cancer Genome Atlas glioblastoma cohort confirmed that increased intratumor prevalence of T(H)1/cytotoxic T lymphocyte/T(H)17 cells linked genetic signatures was associated with good patient prognosis. Therefore, pending final preclinical checks, ICD-based vaccines can be clinically translated for glioma treatment.
Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia
Authors: L Flenghi, M Fagioli, L Tomassoni, S Pileri, M Gambacorta, R Pacini, F Grignani, T Casini, PF Ferrucci, MF Martelli, PG Pelicci, B Falini
Journal: Blood (1995)
The Zinc Glycinate Marker in Human Colon Carcinoma2
Authors: G. Pusztaszeri, C.A. Saravis, N. Zamcheck
Journal: JNCI Journal of the National Cancer Institute (1976)

In an attempt to identify new tumor markers in human colon carcinoma, we produced antisera in rabbits tolerant to normal human tissue antigens and immunized with zinc glycinate-treated extracts of liver metastases from a colon carcinoma. These antisera reacted with carcinoembryonic antigen and with an additional component present in the tumor extracts but not detected in the extracts of normal tissues. The new component, the zinc glycinate marker (ZGM), had an α2 mobility on immunoelectrophoresis, was soluble in 1 M perchloric acid, and had a molecular weight of approximately 2×l06 , as indicated by its elution pattern on Sepharose 6-B chromatography. It differed from alpha fetoprotein, nonspecific cross-reacting antigens (NCA, NGP, or CCA III), ferritin-like molecules, and blood group substances A, B, H, Lewis a, and Lewis b. The ZGM was similarly identified in saline or zinc glycinate extracts of 11 of 23 carcinomas of the colon. With routine hematoxylineosin staining, no histologic differences were apparent between tumors bearing the antigen and those without it.
Interactions of Shope Papilloma Virus and Rabbit Skin Cells <italic>In Vitro</italic>. I. Immunofluorescent Localization of Virus Inocula<xref ref-type="fn" rid="FN2">2</xref>
Authors: John W. Kreider, Charles Breedis, John S. Curran
Journal: JNCI Journal of the National Cancer Institute (1967)

A monolayer culture system has been developed that permits the study of the interactions of purified Shope papilloma virus with skin cells from fetuses of domestic rabbits in vitro. The virus readily adsorbed to these cells, but replication of virus or morphological transformation of the cells could not be shown. However, when the cells were transplanted to the cheek pouch of the hamster, typical papillomas developed.
Symptoms and hospitalization decisions
Authors: J E Mezzich, K J Evanczuk, R J Mathias, G A Coffman
Journal: American Journal of Psychiatry (1984)

On the basis of semistructured evaluations of all new patients presenting for care during a 1-year period at a comprehensive psychiatric facility, the authors systematically assessed the relationship between various aspects of the patients' symptoms and hospitalization decisions. The individual symptoms correlating the highest with hospitalization were self-neglect, disorganized thought process, and impulsivity. Even greater correlations, in increasing order, were obtained for the total number of symptoms present, for delusional psychosis (one of the broad factors underlying the patient's symptoms), and for a linear combination composed of self-neglect, impulsivity, suspiciousness, and suicidal indicators.
Soft drinks industry accuses doctors of having financial interest in pushing for sugar tax
Authors: Ingrid Torjesen
Journal: BMJ (2015)

The head of the association representing soft drinks manufacturers in the United Kingdom has accused organisations representing medical practitioners and nutritionists of pushing for a sugar tax because of a vested financial interest in raising funds to support a publicly funded health service.

In July the BMA called for a 20% tax to be levied on sugary drinks and for the proceeds to subsidise the sale of fruit and vegetables in the UK.1 Public Health England and the House of Commons health select committee also support a sugar tax of at least 20% as part of a range of measures to reduce the amount of free sugar (sugar added to food products …
A phase II trial of fludarabine and cyclophosphamide followed by thalidomide for angioimmunoblastic lymphoma.
Authors: C. Rudin, R. J. Johnson, B. Pottinger, P. Smith, O. A. Adedayo
Journal: Journal of Clinical Oncology (2010)

TPS302 Background: The best treatment for AITL is not known. Some 30% of patients achieve long term remissions but for the majority AITL is an aggressive disease with profound immune dysfunction (Mourad, Blood 2008;111:4463; Dunleavy, Curr Opin Hematol 2007;14:348). Histological subtyping does not aid prognostication, and even though registry data of high dose chemotherapy (HDC) is encouraging, AITL survival in a series of randomised lymphoma trials did not correlate with treatment intensity (Mourad, Blood 2008; 111:4463;Kyriakou, JCO 2008;26:218). We therefore set up a multicenter phase II study to (1) estimate response of AITL to FluCy chemotherapy, and (2) assess incremental anatomical, flow cytometric and molecular response to consolidation with Thal. Methods: Eligible are patients with a first diagnosis of AITL and performance status 0–2. FluCy is given as 4 cycles of Flu 40mg/m2 and Cy 250mg/m2 od po for 3 days every 4 weeks. Thal is given to maximal tolerated dose for 6 months. The two-stage trial aims at recruiting 37 patients in 3 years. It opened in February 2009. Novel aspects of this trial are (1) first prospective trial in AITL investigating two immune interventions-ablation followed by cytotoxic T and NK cell stimulation (Hayashi, BJH 2005;128:192); (2) investigation of two therapeutic interventions sequentially; (3) definition of an incremental response rate for the second intervention based on the frequent presence of circulating lymphoma cells in AITL (Baseggio, Leukemia 2005;20:296). In the first year, only 5 patients were enrolled. Difficulties encountered were (1) protracted set up due to changes in regulatory status of Thal; (2) low pick up rate among trial centers because of high administrative work for low recruitment rate; (3) perception in many larger centers that younger patients should be offered HDC in first remission; (4) drop out rate during first phase of trial higher than expected because of skewing of the patient population toward the elderly (not fit for HDC) so that Thal question, which needs 26 patients, may not be answered; (5) lack of facilities for storage of fresh frozen tissue in most prospective trial centers , precluding linkage of trial data to gene expression profiling. No significant financial relationships to disclose.
Evaluation of the Preventive Effect of Dexamethasone for Rash in Patients Treated with Pemetrexed
Authors: Naoko Usui, Yoko Kondo, Norio Okamoto, Hidekazu Suzuki, Masumi Sando, Yuya Fukuchi, Motohiro Tamiya, Naoko Morishita, Takayuki Shiroyama, Tomonori Hirashima
Journal: Annals of Oncology (2014)
QUANTIFICATION OF RADIATION-INDUCED LUNG DAMAGE WITH CT SCANS: THE POSSIBLE BENEFIT FOR RADIOGENOMICS
Authors: Dirk De Ruysscher, Hoda Sharifi, Gilles Defraene, Sarah L Kerns, Kim De Ruyck, Stephanie Peeters, Johan Vansteenkiste, Robert Jeraj, Frank Van den Heuvel, Wouter Van Elmpt
Journal: Journal of Thoracic Oncology (2013)
A Randomized Placebo-Controlled Trial of Intradermal Grass Pollen Immunotherapy for Seasonal Allergic Rhinitis
Authors: Anna D. Slovick, Abdel Douiri, Rachel Muir, Andrea Guerra, Kostas Tsioulos, Evie Haye, Emily Lam, Joanna Kelly, Janet Peacock, S. Ying, Mohamed H. Shamji, David Cousins, Stephen R. Durham, Stephen Till
Journal: Journal of Allergy and Clinical Immunology (2016)
Amplitude Spectrum Area-Based Defibrillation Decision During Prehospital Cardiopulmonary Resuscitation in Lombardia, Italy
Authors: Giuseppe Ristagno, Carla Fornari, Yongqin Li, Francesca Fumagalli, Andrea Finzi, Tommaso Mauri, Gianpiera Rossi, Roberto Latini, Giancarlo Cesana, Antonio Pesenti
Journal: Circulation (2012)
Geriatric Assessment-Guided Care Processes for Older Adults: A Delphi Consensus of Geriatric Oncology Experts
Authors: Supriya Gupta Mohile, Carla Velarde, Arti Hurria, Allison Magnuson, Lisa Lowenstein, Chintan Pandya, Anita O'Donovan, Rita Gorawara-Bhat, William Dale
Journal: Journal of the National Comprehensive Cancer Network (2015)

Background: Structured care processes that provide a framework for how oncologists can incorporate geriatric assessment (GA) into clinical practice could improve outcomes for vulnerable older adults with cancer, a growing population at high risk of toxicity from cancer treatment. We sought to obtain consensus from an expert panel on the use of GA in clinical practice and to develop algorithms of GA-guided care processes. Methods: The Delphi technique, a well-recognized structured and reiterative process to reach consensus, was used. Participants were geriatric oncology experts who attended NIH-funded U13 or Cancer and Aging Research Group conferences. Consensus was defined as an interquartile range of 2 or more units, or 66.7% or greater, selecting a utility/helpfulness rating of 7 or greater on a 10-point Likert scale. For nominal data, consensus was defined as agreement among 66.7% or more of the group. Results: From 33 invited, 30 participants completed all 3 rounds. Most experts (75%) used GA in clinical care, and the remainder were involved in geriatric oncology research. The panel met consensus that “all patients aged 75 years or older and those who are younger with age-related health concerns” should undergo GA and that all domains (function, physical performance, comorbidity/polypharmacy, cognition, nutrition, psychological status, and social support) should be included. Consensus was met for how GA could guide nononcologic interventions and cancer treatment decisions. Algorithms for GA-guided care processes were developed. Conclusions: This Delphi investigation of geriatric oncology experts demonstrated that GA should be performed for older patients with cancer to guide care processes.
Abstract 16712: Inhibition of Four-and-a-Half LIM Domain Protein-2 Attenuates Atherogenesis in ApoE-/- Mice: Role of Immune T-Cells
Authors: Talin Ebrahimian, Maryam Heidari, Catherine A Lemarie, Stefania Simeone, David Simon, Daniel Rivas, Koren Mann, Stephanie Lehoux, Sven Wassmann
Journal: Circulation (2013)

Four-and-a-half LIM domain protein-2 (FHL2) is expressed in vascular cells. FHL2 negatively regulates endothelial cell survival and migration, but its role in atherogenesis is unknown. Methods and ...
Hyperplastic and Early Neoplastic Lesions of the Liver in Buffalo Strain Rats of Various Ages Given Subcutaneous Carbon Tetrachloride&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Melvin D. Reuber, E. Lee Glover
Journal: JNCI Journal of the National Cancer Institute (1967)

Inbred Buffalo male and female rats, 4, 12, 24, and 52 weeks old, were given subcutaneous injections of carbon tetrachloride. Preneoplastic and early neoplastic lesions of the parenchymal cells developed in the liver. The 24- and 52-week-old animals of both sexes had more hyperplastic nodules as well as an occasional small hepatocellular carcinoma. The number of hyperplastic lesions per liver and size of lesions were larger in females than in males. In contrast, the fluorenylamines have been more effective in the males. Four-day-old animals given carbon tetrachloride died with hepatic and renal necrosis.
Morcellation and risk of malignancy in presumed ovarian fibromas/fibrothecomas
Authors: Wouter Froyman, Chiara Landolfo, Frédéric Amant, Thierry Van den Bosch, Ignace Vergote, An Coosemans, Antonia Testa, Lil Valentin, Tom Bourne, Ben Van Calster, Dirk Timmerman
Journal: The Lancet Oncology (2016)
Sorafenib Treatment Following Hematopoietic Stem Cell Transplant In Pediatric FLT3/ITD+ AML
Authors: Jessica Pollard, Bill H Chang, Todd Michael Cooper, Thomas Gross, Sumit Gupta, Phoenix A. Ho, Suzanne M. McGoldrick, Tanya C. Watt, India Sisler, Blythe Thomson, Ann E Woolfrey, Soheil Meshinchi
Journal: Blood (2013)
PD-0016 KSR1 Gene Polymorphism in Mcrc Patients Treated with First-Line Folfiri and Bevacizumab
Authors: Marta Schirripa, Fotios Loupakis, Chiara Cremolini, Yang Dongyun, Melissa Janae Labonte, Wu Zhang, Lisa Salvatore, Takeru Wakatsuky, Carlotta Antoniotti, Giuseppe Aprile, Sara Lucchesi, Georgios Giamas, Stebbing Justin, Alfredo Falcone, Heinz Joseph Lenz
Journal: Annals of Oncology (2012)
Abstract 4: The Mitochondrial Ca <sup>2+</sup> Transport and ATP Production Through Sigma-1 Receptor in Heart
Authors: Kohji Fukunaga, Hideaki Tagashira
Journal: Circulation Research (2012)

Objective: Although sigma-1 receptor is originally postulated as an opioid receptor in the central nervous system, we recently defined the higher expression of sigma-1 receptor in cardiac ventricle and kidney as compared to brain tissues (Expert Opin Ther Targets 2010;14:1009-1022). To address the question whether mitochondrial Ca 2+ transport and ATP production in heart are regulated by sigma-1 receptor stimulation, we tested the anti-hypertrophic effects of the specific sigma-1 receptor agonist, SA4503 in transverse aortic constriction (TAC) mice. Methods: We treated mice with SA4503 (0.1, 0.3 and 1.0 mg/kg) orally once a day for 4 weeks after TAC. The cardiac constriction was monitored by echocardiography. The mitochondrial Ca 2+ transport and ATP production with or without SA4503 treatment were measured in cultured neonatal cardiomyocytes. Results: The sigma-1 receptor expression in the left ventricle (LV) decreased significantly over the 4 weeks. SA4503 administration significantly attenuated TAC-induced myocardial hypertrophy concomitant with the recovery of sigma-1 receptor expression in LV. SA4503 also ameliorated the impaired LV fractional shortening. We also investigated the role of sigma-1 receptor for sarcoplasmic reticulum (SR)-mitochondrial Ca 2+ transport in cultured neonatal rat ventricular cardiomyocytes. Exposure to angiotensin II (Ang II) for 72 hr elicited marked cardiomyocyte hypertrophy and declined phenylephrine (PE)-induced Ca 2+ mobilization into cytosol and mitochondria. SA4503 treatment restored significantly the reduced PE-induced Ca 2+ mobilization into mitochondria. Importantly, The Ang II-induced hypertrophy in vitro and transverse aortic constriction-induced cardiac dysfunction in vivo were associated with the reduced ATP concentration, which was completely restored by SA4503 treatment. NE-100, a sigma-1 receptor selective antagonist, abolished these effects induced by SA4503. Conclusion: The specific sigma-1 receptor agonist, SA4503 ameliorates AngII-induced cardiomyocyte hypertrophy and TAC-induced cardiac dysfunction through restoration of SR-mitochondria Ca 2+ transport via sigma-1 receptor stimulation, thereby promoting mitochondrial ATP production.
History “will not thank” NHS leaders who ignore collaborative opportunities
Authors: Gareth Iacobucci
Journal: BMJ (2016)

Simon Stevens, the head of NHS England, has warned local healthcare leaders that “history will not thank them” if they are unwilling to set aside their differences and work together to transform the way healthcare is delivered.

With the health service facing the perfect storm of a health gap, a care gap, and a fiscal crisis, NHS England has asked local organisations to collaborate with each other and with local government to draw up sustainability and transformation plans focusing on their local populations’ needs.

Speaking at a King’s Fund event on how to advance the plans, Stevens said that local leaders must disregard traditional silos and embrace new ways of working to help keep the …