tbuckley/cabot-search huggingface dataset:
Abstract 1496: Changes in white adipose tissue progenitor populations with ovarian cancer
Authors: Amanda A. Shea, Courtney A. Cohen, Paul C. Roberts, Eva M. Schmelz
Journal: Cancer Research (2012)

Abstract Ovarian cancer is the fourth leading cause of cancer death in women and has the highest mortality rate of all gynecological malignancies. Among the greatest risk factors are age, reproductive history, hormone therapy, and more recently suggested, obesity. Currently, the mechanism for how obesity contributes to ovarian cancer is unknown, but there is potential for adipose tissue-associated cells to be key players in this pathogenesis. The stromal vascular fraction (SVF) of white adipose tissue is a rich source of various stem and progenitor cell populations, which can be recruited by cancer cells to enhance cancer progression and metastatic potential. Studies have shown that there is an increase in progenitor populations within the adipose tissue with obesity and age, two risk factors for ovarian cancer. While it has been shown that SVF cells can contribute to cancer, it has not been determined what impact cancer progression has on adipose tissue. It is plausible that ovarian cancer has systemic effects, which may influence cell populations within adipose tissue to promote metastases. Our lab has developed a spontaneously transformed murine ovarian surface epithelial (MOSE) cell model that becomes increasingly more aggressive with repeated passaging. Late passage cells rapidly form tumors when injected into mice, while earlier passage cells do not. Using this model, we investigated the effects of ovarian cancer on systemic changes in progenitor populations. Firefly luciferase-expressing MOSE-L TICv cells, a highly aggressive, metastatic tumor-initiating cell variant were injected into the peritoneal cavity of C57BL/6 mice and stem/progenitor populations and various immune cell populations within the perigonadal white adipose tissue, blood, ascites, and omentum were immunophenotyped by flow cytometry. Changes in gene expression profiles were also analyzed using quantitative real-time PCR. Interestingly, peritoneal dissemination changed the profile and composition of progenitor populations in the various tissues, suggesting that ovarian cancer does have a more widespread impact, affecting the blood and perigonadal adipose tissue. Additionally, co-culture studies demonstrate that MOSE cells and SVF associated cells positively interact enhancing tumor spheroid growth and provide survival signals. This suggests a synergistic relationship between the MOSE and SVF cells. These discoveries may provide a mechanistic link for the detrimental impact of obesity on ovarian cancer progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1496. doi:1538-7445.AM2012-1496
Home Transfusion for Patients with Hemophilia A
Authors: S. Frederick Rabiner, Margaret C. Telfer
Journal: New England Journal of Medicine (1970)

A program was established to train relatives of hemophiliac patients deficient in antihemophilic factor to administer concentrate of the factor intravenously at home after telephone consultation with the physician. Eighteen months' experience with the program indicates that with careful medical supervision, home transfusion is practical and safe. Consumption of antihemophilic-factor concentrate is increased, probably because of greater willingness to report hemorrhages. The number of school or work days lost is decreased on the program, but it is too early to estimate lower morbidity in terms of permanent joint damage. Patients and their relatives are enthusiastic because of the time saved, rapid relief of pain and opportunity of helping the patient within the family unit. Until prophylactic therapy becomes feasible, home transfusion is a reasonable substitute.
FRI0098 The expression of plasma MIR-155 and MIR-146A in RA patients
Authors: Z. Ye, Z. Yin, J. Huang, H. Sun, X. Luo
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background</h3> MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted mRNAs. It is known that miRNAs are present in human plasma in a stable form and they can be potential non-invasive biomarkers for early detection of cancers or some other diseases. Recent reports showed that the expression of miR-146a, miR-155, miR-132, miR-16 inRA peripheral blood mononuclear cells (PBMC) was higher than healthy control. <h3>Objectives</h3> In this study, the expression of miR-155 and miR-146a is determined in PBMC and plasma from rheumatoid arthritis (RA) patients. <h3>Methods</h3> PBMC and plasma were separated from peripheral blood of 34 RA patients and 15 healthy individuals. Total RNAs were isolated and miRNAs were purified. The levels of miR-155 and miR-146a were determined by quantitative reverse transcription PCR (qRT-PCR). U6 was used as housekeeping control. The amount of target miRNA was normalized relative to the amount of U6 (ΔCt =ΔCt<sub>miRNA</sub>-ΔCt<sub>U6</sub>). Relative expression levels were expressed as 2<sup>-Δ Ct</sup>. The 2-sample t-test was used for all 2 sample comparisons (SPSS, version 13.0). <i>P</i>&lt;0.05 was considered significant. <h3>Results</h3> The expression of PBMC and plasma miR-155 was higher in the RA patients than that in the healthy control individuals (0.08±0.08 vs 0.05±0.03, <i>P</i>&lt;0.05; 5.90±6.70 vs 1.27±2.00, <i>P</i>&lt;0.05). The expression of miR-146a in PBMC and plasma in RA patients and controls is 1.33±1.19 vs 0.79±0.55 (<i>P</i>&lt;0.05)and 741.43±1000.64 vs 299.81±294.92 (<i>P</i>&gt;0.05). According to their DAS28 value, RA patients were divided into high activity group (23 cases, DAS28≥5.0) and low activity group (11 cases, DAS28&lt;5.0). The plasma miR-155 and miR-146a expression was significantly higher in high activity group than that in low activity group. There was no significantly difference in the expression of PBMC miR-155 and miR-146a between the two groups. <h3>Conclusions</h3> The expression of PBMC and plasma miR-155 and miR-146a is higher in RA patients. The expression of plasma miR-155 and miR-146a is associated with RA patients' activity. Plasma miR-155 and miR-146a may be potential non-invasive biomarkers for RA diagnosis and RA activity assessment. <h3>Disclosure of Interest</h3> None Declared
Limiting the Duration of Opioid Prescriptions
Authors: Brian T. Bateman, Niteesh K. Choudhry
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
OC-009 Endoscopic Therapy for Zenker’S Diverticulum – a “Bridge” too far for Gastroenterologists?
Authors: M Smith, M Widlak, N Molony, S Ishaq
Journal: Gut (2013)

<h3>Introduction</h3> Zenker’s diverticulum, caused by dysfunction of the cricopharyngeal (CP) muscle, is a disease of the elderly causing dysphagia. Although rigid endoscopic CP myotomy is the treatment of choice, flexible endoscopic therapy is another technique available. It is performed under sedation without need for anaesthetic or neck extension, a key advantage in elderly patients with significant co-morbidity. <h3>Methods</h3> We describe the first UK experience of endoscopic CP myotomy for Zenker’s diverticulum. <h3>Results</h3> 4 patients (3 male) were referred, aged 74, 73, 60, 80 respectively, with proven Zenker’s diverticulum on barium radiology and characteristic symptomatology. Zenker length was 7.0, 4.0, 2.5, 2.5cm respectively. 2 patients were refused surgery due to cardiovascular co-morbidity, 1 due to limited neck extension with 1 case personal preference. The procedure was performed using propofol sedation. The muscle bridge was cut by hook knife electrocautery alone (3) or with Argon (1). A supplementary clip was applied post electrocautery in 1 case. All patients were observed for 24 hours for signs of perforation and then discharged. There were no complications. At 4 weeks 3 patients had complete resolution of their symptoms, 1 with marked improvement. Follow up time to date 3.4.7.11 months respectively. There was no reported recurrence of symptoms. <h3>Conclusion</h3> Diverticulotomy with a flexible endoscope is an effective treatment for Zenker’s diverticulum. It is a relatively simple yet under-utilised technique that avoids general anaesthesia in elderly/high-risk patients. <h3>Disclosure of Interest</h3> None Declared
Cytokines in Alcoholic and Nonalcoholic Steatohepatitis
Authors: Herbert Tilg, Anna Mae Diehl
Journal: New England Journal of Medicine (2000)

Cytokines are pleiotropic regulatory peptides that can be produced by virtually every nucleated cell in the body, including most types of liver cells.1,2 The cytokine family consists of several subfamilies: the interleukins, the tumor necrosis factor (TNF) family, interleukin-6 and related cytokines, interferons, chemokines such as interleukin-8, transforming growth factor β, colony-stimulating factors, and others.In most tissues, including the liver, constitutive production of cytokines is absent or minimal. However, as physiologic and pathologic stimuli activate cells, the production of these autocrine, paracrine, and endocrine effector molecules increases, and they, in turn, orchestrate the tissue's response to the stimulus. . . .
Placement of an esophageal self-expandable metal stent through a percutaneous endoscopic gastrostomy tract, for endoscopic therapy of upper gastrointestinal bleeding
Authors: T. Baron, L. Wong Kee Song
Journal: Endoscopy (2012)

Slim endoscopes can be passed through gastrostomy tracts, but dilation is required for the passage of standard endoscopes, which may result in tract disruption. Large-diameter covered self-expandable metal stents (CSEMS) have been placed through percutaneous tracts to enable endotherapy.
High School Students Involved In Cancer Research
Authors: J. Corliss
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article High School Students Involved In Cancer Research Get access Julie Corliss Julie Corliss Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 17, 6 September 1989, Pages 1280–1281, https://doi.org/10.1093/jnci/81.17.1280 Published: 06 September 1989
Tiny fibrovascular polyps of the esophagus as incidental findings – look carefully or you might miss them
Authors: L. Lenz, G. Luz, A. Felipe-Silva, F. Nakao, E. Libera, D. Chaves, B. Sugai, R. Rohr
Journal: Endoscopy (2011)

Fibrovascular polyps of the esophagus are rare benign lesions that arise from the cervical esophagus. Most of them are only diagnosed when their size induces symptoms [1].
Alendronate for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
Authors: Kenneth G. Saag, Ronald Emkey, Thomas J. Schnitzer, Jacques P. Brown, Federico Hawkins, Stefan Goemaere, Gorm Thamsborg, Uri A. Liberman, Pierre D. Delmas, Marie-Pierre Malice, Michelle Czachur, Anastasia G. Daifotis, Nancy Lane, Ricardo Correa-Rotter, Melissa Yanover, Rene Westhovens, Sol Epstein, Jonathan D. Adachi, Patrice Poubelle, Jose Melo-Gomes, Jose A. Rodriguez-Portales
Journal: New England Journal of Medicine (1998)

Osteoporosis is a common complication of long-term glucocorticoid therapy for which there is no well-proved preventive or restorative treatment.
OP0069-HPR The influence of weather on daily pain and fatigue in female patients with fibromyalgia
Authors: E. Bossema, H. van Middendorp, J.W. Jacobs, J.W. Bijlsma, R. Geenen
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Patients with fibromyalgia often report that the weather aggravates their symptoms, but research so far did not conclusively demonstrate such a relation. <h3>Objectives</h3> To examine the association between weather conditions and daily symptoms of pain and fatigue in female patients with fibromyalgia, and to identify patient characteristics explaining individual differences in these associations. <h3>Methods</h3> Female patients with fibromyalgia (<i>n</i>=333, mean age 47.0 years, mean time since diagnosis 3.5 years) completed diaries, including questions on immediate pain and fatigue during 28 consecutive days. The daily weather conditions that were obtained from the Royal Netherlands Meteorological Institute (KNMI) in “De Bilt99, the Netherlands, included air temperature, sunshine duration, rainfall, atmospheric pressure, relative humidity, and wind speed. Multilevel regression analysis was applied. Considering that six weather conditions were included, the <i>p</i>-value was set to 0.008. <h3>Results</h3> Few significant, but small associations were found between weather conditions and symptoms of pain and fatigue. Pain was associated with an increase in relative humidity on the previous day (<i>p</i>=0.004) and with rain on the same day (<i>p</i>=0.003); fatigue was associated with a higher air temperature on the previous day (<i>p</i>=0.001).Patients differed from each other with respect to associations of weather conditions with pain and fatigue (see Figure). However, no demographic, functional or mental patient characteristic was found to explain these differences in weather sensitivity. <h3>Conclusions</h3> This study provides few indications for at best a small overall influence of weather conditions on daily pain and fatigue in female patients with fibromyalgia. Associations between weather and symptoms differ between patients, but it is unclear which patient characteristics play a role in this. <h3>Disclosure of Interest</h3> None Declared
P2-09-13: The Value of FDG PET/CT in Screening Detected Breast Cancer Patients.
Authors: HR Koo, WK Moon, N Cho, JM Chang, KW Kang, A Yi
Journal: Cancer Research (2011)

Abstract Background. To evaluate the diagnostic value of FDG PET/CT for initial staging of screening detected breast cancer. Methods. Between January 2008 and June 2010, a total of 77 women (mean age 54 years, range 31–77 years) with screening detected primary breast cancer (mean invasive tumor size 1.65cm, range 1–70mm) underwent whole body fluorine-18 fluorodeoxyglucose (FDG) PET/CT for initial staging and were included in this retrospective study. Two patients had bilateral breast cancer. The sensitivity of FDG PET/CT for the detection of primary tumor and the sensitivity, specificity, PPV and NPV for the detection of axillary lymph node metastases were determined. Systemic staging with whole body FDG PET/CT was also performed. For analysis of diagnostic performance of FDG PET/CT, quantitative measurement of the maximum standardized uptake value (SUVmax) criteria 1.0 was used. The final histopathology following surgery served as the gold standard. Results. The primary tumor was FDG PET/CT positive in 65 of 79 lesions (82%). Depending on the tumor size, there was a variation in diagnostic sensitivity (63% in ≤ 1cm tumor, n=19 vs. 88% in &amp;gt; 1cm tumor, n=60) and the uptake of FDG was significantly higher in &amp;gt; 1cm tumor than in ≤ 1cm tumor (mean SUVmax 2.85 vs. 1.11, p&amp;lt;0.05). The uptake of FDG was significantly higher in ductal carcinomas compared to lobular carcinomas (median SUVmax 2.0, n=72 vs. 1.3, n=7, p&amp;lt;0.05). Of the 77 patients included in this study, 16 patients were found to have axillary node metastasis. The sensitivity, specificity, PPV and NPV of FDG PET/CT for detection of LN metastasis were 63% (10/16), 89% (54/61), 59% (10/17) and 90% (54/60), respectively. FDG PET/CT showed distant uptake in 9 patients and 8 of 9 were false positive results. 4 lesions were confirmed histopathologically as benign and 4 lesions were evaluated with radiologic methods. One of nine was true positive result. Distant involvement was skeletal and visible on the conventional bone scintigraphy. The patient staged as cT1N3M1. Conclusion. FDG PET/CT has limited value for the initial staging of screening detected breast cancer patients. Considering high costs, radiation exposure and false positivity, FDG PET-CT is not recommended for the preoperative evaluation of screening detected breast cancer patients. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-09-13.
AB0986 Pooled safety data from elderly arthritis patients in 21 clinical trials
Authors: M. Noyes Essex, R. Zhang, S.R. Mallen
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Approximately one half of adults aged ≥65 years in the United States report having doctor-diagnosed arthritis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used by the elderly to manage arthritis pain. While these drugs are effective, the risk-benefit profile needs to be individualized for each patient. Data are needed for the elderly population. <h3>Objectives</h3> The objective of this pooled analysis was to compare the adverse event (AE) profile of the cyclooxygenase-2 selective NSAID celecoxib and nonselective NSAIDs as reported by elderly patients with arthritis aged ≥65 years. <h3>Methods</h3> This was an age-defined subgroup analysis of safety data in patients aged ≥65 years with osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis from 21 randomized, parallel-group trials. Selected trials had a duration of ≥2 weeks and at least 1 celecoxib 200-400 mg/d and 1 nonselective NSAID (naproxen, ibuprofen, or diclofenac) arm at prescription doses. The analysis included all reported AEs, including gastrointestinal, cardiovascular, and hepatic AEs. <h3>Results</h3> A total of 9461 patients aged ≥65 years at the time of study enrollment were categorized into celecoxib 200 mg total daily dose (TDD) (n=3287), 400 mg TDD (n=2585), naproxen (n=1104), ibuprofen (n=151), and diclofenac (n=2334) groups. Overall, AEs were less frequently reported in the celecoxib groups (44.8% 200 mg TDD, 46.1% 400 mg TDD) than in the nonselective NSAID groups (naproxen 58.6%, ibuprofen 62.9%, diclofenac 48.8%). Most frequently reported AEs were related to the digestive system, with fewer being reported by celecoxib-treated patients (19.4% 200 mg TDD, 21.0% 400 mg TDD) than by those receiving naproxen (33.6%), ibuprofen (30.5%), and diclofenac (24.2%). Cardiovascular AEs were rarely reported in all groups (&lt;1%). Hepatic AEs were more commonly reported in the diclofenac group (3.8%; all other groups ≤1%). Central and peripheral nervous system AEs were most common in the ibuprofen group (17.9%; other groups ranged from 8.2%–11.1%); headache was reported by 11.9% of the ibuprofen group (other groups ranged from 3.6%–6.8%). Anemia was most common in the ibuprofen group (5.3%, other groups ranged from 0.7%–1.8%), as was ecchymosis (2.6% for ibuprofen, other groups ranged from 0.2%–0.8%). <h3>Conclusions</h3> The overall incidence of AEs in this pooled analysis of elderly arthritis patients was lower in celecoxib-treated patients than in patients treated with naproxen, ibuprofen, and diclofenac. The results of this analysis should be taken into account when treating elderly patients with arthritis. <h3>Disclosure of Interest</h3> M. Noyes Essex Employee of: Pfizer Inc, R. Zhang Employee of: Pfizer Inc, S. Mallen Employee of: Pfizer Inc
NEUROCOGNITIVE ABILITIES IN CHILDREN WHO HAVE UNDERGONE THE FONTAN OPERATION: THE ASSOCIATION BETWEEN HYPOPLASTIC LEFT HEART SYNDROME AND OUTCOMES
Authors: Billie-Jean Martin, M. Florencia Ricci, Joseph Atallah, Gwen Alton, Ari R. Joffe, David Ross, Ivan Rebeyka, Charlene Robertson
Journal: Journal of the American College of Cardiology (2016)
Molecular Evidence of Sexual Transmission of Ebola Virus
Authors: Suzanne E. Mate, Jeffrey R. Kugelman, Tolbert G. Nyenswah, Jason T. Ladner, Michael R. Wiley, Thierry Cordier-Lassalle, Athalia Christie, Gary P. Schroth, Stephen M. Gross, Gloria J. Davies-Wayne, Shivam A. Shinde, Ratnesh Murugan, Sonpon B. Sieh, Moses Badio, Lawrence Fakoli, Fahn Taweh, Emmie de Wit, Neeltje van Doremalen, Vincent J. Munster, James Pettitt, Karla Prieto, Ben W. Humrighouse, Ute Ströher, Joseph W. DiClaro, Lisa E. Hensley, Randal J. Schoepp, David Safronetz, Joseph Fair, Jens H. Kuhn, David J. Blackley, A. Scott Laney, Desmond E. Williams, Terrence Lo, Alex Gasasira, Stuart T. Nichol, Pierre Formenty, Francis N. Kateh, Kevin M. De Cock, Fatorma Bolay, Mariano Sanchez-Lockhart, Gustavo Palacios
Journal: New England Journal of Medicine (2015)

A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD. (Funded by the Defense Threat Reduction Agency and others.).