tbuckley/cabot-search huggingface dataset:
Abstract 12913: Local Production of Fatty Acid-Binding Protein 4 Leads to Coronary Atherosclerosis
Authors: Masato Furuhashi, Shutaro Ishimura, Hideki Ota, Yusuke Okazaki, Masayuki Koyama, Takahiro Fuseya, Tomohiro Mita, Marenao Tanaka, Hideaki Yoshida, Tetsuji Miura
Journal: Circulation (2012)

[Background] Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is expressed in both adipocytes and macrophages, contributing to the development of insulin resistance and susceptibility to atheroscler...
Selective Inhibitor of Nuclear Export Selinexor (KPT-330) and BCL2 Inhibitor ABT-199 Enhance the Anti-Lymphoma Effect of BTK Inhibitor Ibrutinib in Mantle Cell Lymphoma
Authors: Yoko Tabe, Masako Harada, Yuka Miyamae, Saiko Kazuno, Tsutomu Fujimura, Takashi Ueno, Takashi Miida, Marina Konopleva, Michael Andreeff
Journal: Blood (2014)
NEMESI: A retrospective observational longitudinal study to investigate italian early breast cancer (EBC) patient characteristics and treatment.
Authors: F. Cognetti, S. Gori, V. Adamo, A. Molino, G. Benedetti, A. Casadei Gardini, S. Gildetti, F. Riccardi, S. Rossi, L. Del Mastro
Journal: Journal of Clinical Oncology (2010)

e11046 Background: Adjuvant treatment of EBC is rapidly evolving and new findings influence differently the clinical practice. The NEMESI study examined clinical practices adopted by Italian Oncology institutions with regards adjuvant treatment of EBC. Methods: This retrospective observational study describes adjuvant treatment of EBC in Italy, involving, between January 1 and June 30, 2008, at least 1,500 cases, 30 consecutive in each 50 centers, selected on respect of the Italian oncology units censed by Italian Association of Medical Oncology, and representing geographical distribution (northern, central, and southern Italy) and institution typology (IRCCS, private institutes, university institutes, hospital units). Inclusion criteria: age ≥ 18 years, histological diagnosis of early stage operated breast cancer (stage I-II TNM AJCC version VI), receiving at least one cycle of adjuvant, chemotherapy and/or hormone therapy. Results: 1,895 cases from 63 Italian centers were included. Preliminary data are presented for 1,542/1,895 patients. Tumor characteristics: pT1: 67.3% (22.1%: pT1mic + pT1a + pT1b); pN0: 60.9%; pN1: 29.5%; pN2: 5.8%; pN3: 3.8%; ER pos (≥10%): 80.6%; ER neg (0-9%): 19.4%; median ki67: 15%; HER2 pos:18.0%. Adjuvant treatment without chemotherapy was administered to 650 patients (42.2%), while the remaining 892 (57.8%) received systemic chemotherapy. Conclusions: Italian oncology centers frequently use adjuvant chemotherapy for EBC. There is still widespread use of first-generation chemotherapy drugs independent of disease severity. In particular for the pN0-pN1 class there is an underuse of taxane-based chemotherapy, which is administered above all for EBC with high recurrence risk (pN2 and pN3). Study sponsored by sanofi-aventis Italy. pN N %CMF-like N % Anthracycline N % Taxane + anthracycline N % Taxane alone N pN0 55 13.6% 256 63.7% 73 18.1% 18 4.4% 402 pN1 23 6.5% 165 46.5% 148 41.7% 19 5.3% 355 pN2 8 10.3% 12 15.4% 58 74.4% 0 0% 78 pN3 4 7.3% 12 22.1% 37 68.8% 1 1.8% 54 Total 90 10.1% 445 50.0% 316 35.6% 38 4.3% 889 Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration sanofi-aventis sanofi-aventis
Biochemical Purification of Antineoplastic Agents Obtained From Sturgeon Serum
Authors: Deborah J. Cameron
Journal: JNCI Journal of the National Cancer Institute (1984)

Discontinuous and continuous DEAE-Sephadex ion-exchange gradients were utilized to purify two sturgeon serum factors (A2 and B2) that possessed cytotoxic activity in vitro against human tumor cells but not against normal cells. After rabbit antisturgeon factor A2 or B2 was prepared, the antibodies were insolubilized. Sturgeon serum then was adsorbed to the insolubilized antibodies, and factors A2 and B2 were isolated in quantities large enough to conduct biologic studies. When the two factors purified either by ion-exchange chromatography or immunoadsorbent columns were examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and isoelectric focusing, factor A2 consisted of one protein band with a molecular weight greater than 68,000 and an isoelectric point of approximately 6.5. Likewise, factor B2 also consisted of one protein band with a molecular weight in excess of 68,000 and an isoelectric point of approximately 7.5. Both factors A2 and B2 were destroyed either by heating at 56 degrees C for 30 minutes or by heating at 100 degrees C for 2 minutes. Furthermore, the mechanism of tumor killing by the sturgeon factors appears to be by means of a soluble factor. When the kinetics of tumor killing was studied, the sturgeon factors were noncytotoxic after 4 or 8 hours of incubation and became cytotoxic after 24 hours of incubation.
Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization
Authors: GJ Lieschke, D Grail, G Hodgson, D Metcalf, E Stanley, C Cheers, KJ Fowler, S Basu, YF Zhan, AR Dunn
Journal: Blood (1994)
Clinical and Morphological Characteristics of P53-Positive Breast Cancer Stage I in Russian and Dutch Populations
Authors: I.V. Kolyadina, P.J.K. Kuppen, C. van de Velde, N.G. Dekker-Ensink, E. Bastiaannet, B. Prinse, C. Engels, A. Karseladze, I.V. Poddubnaya, V. Ermilova, D. Komov, G. Frank
Journal: Annals of Oncology (2014)
Mitochondrial DNA-like sequence in the nuclear genome of an akodontine rodent.
Authors: M F Smith, W K Thomas, J L Patton
Journal: Molecular Biology and Evolution (1992)

Initial amplification and sequencing of a 366-bp fragment of the cytochrome b gene by a conserved primer pair (MVZ 03 and MVZ 04) revealed a nonfunctional copy of the gene with two deletions (one of which is 17 bp in length and the other of which is 3 bp in length) in Chroeomys jelskii, a South American akodontine rodent. By means of an alternative primer to MVZ 03--namely, MVZ 05--from the region of the tRNA for glutamic acid, a functional copy of cytochrome b was subsequently amplified. Both primer pairs amplify functional sequence when applied to purified mitochondrial DNA (mtDNA). Restriction-endonuclease digestion of purified mtDNA from C. jelskii did not reveal any additional sets of bands that would suggest heteroplasmy in the mitochondrial genome. When probed with both functional and nonfunctional gene fragments, MboI restriction digests revealed the same pattern, providing further evidence that the nonfunctional copy must be located in the nucleus. Observed differences in the mitochondrial and nuclear sequences from two populations are consistent with a faster rate of change in mtDNA than in nuclear DNA.
Blood flow does not redistribute from respiratory to leg muscles during exercise breathing heliox or oxygen in COPD
Authors: Zafeiris Louvaris, Ioannis Vogiatzis, Andrea Aliverti, Helmut Habazettl, Harrieth Wagner, Peter Wagner, Spyros Zakynthinos
Journal: European Respiratory Journal (2014)

In COPD, one of the proposed mechanisms for improving exercise tolerance, when work of breathing is experimentally reduced, is redistribution of blood flow from the respiratory to locomotor muscles. We investigated whether exercise capacity is improved on the basis of blood flow redistribution whilst breathing heliox (designed to reduce work of breathing) and oxygen (O2) (designed to enhance systemic O2 delivery). Intercostal, abdominal and vastus-lateralis muscle perfusion was simultaneously measured in 10 patients (FEV1:46±12% pred.) by NIRS using indocyanine green dye. Measurements were performed during constant-load exercise at 75% peak workload to exhaustion while breathing room air, and then at the same workload, breathing either normoxic heliox (helium 79% and oxygen 21%) or 100% O2, the latter two in balanced order. Times to exhaustion whilst breathing heliox and O2 did not differ (659±42 and 696±48 sec, respectively), but both exceeded that on air (406±36 sec, p<0.001). At exhaustion, intercostal and abdominal muscle blood flow during heliox (9.5±0.6 and 8.0±0.7 ml/min/100g, respectively) was greater compared to air (6.8±0.5 and 6.0±0.5 ml/min/100g, respectively; p<0.05), whilst neither intercostal nor abdominal muscle blood flow differed between O2 and air. Quadriceps muscle blood flow was greater with heliox compared to air (30.2±4.1 versus 25.4±2.9 ml/min/100g; p<0.01), but did not differ between air and O2. While our findings confirm that reducing the burden on respiration by heliox or O2 prolongs exercise tolerance in COPD, they do not support the hypothesis that redistribution of blood flow from the respiratory to locomotor muscles is the explanation.
Particles for Local Delivery of Proteins Using Intra‐Articular Route
Authors: Khosrow Khodabandehlou, Shaomin Tian, James C. Luft, Saad A. Khan, Joseph M. DeSimone
Journal: Advanced Healthcare Materials (2016)

Designing a vehicle for local delivery of proteins using intra-articular route is an attractive option to minimize the adverse effects associated with systemic exposure and to maximize the efficacy. Slowly dissolving silylated microparticles are designed with specific size and shape that are capable of extending the retention time of a model protein (bovine serum albumin) in the murine knee joint. No cytotoxicity is observed for the reconstituted formulation when tested against synovial fibroblasts and RAW 264.7 macrophages. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Computed tomography features of pulmonary non-Hodgkin’s lymphoma and special emphasis on Richter’s syndrome
Authors: M. Yc, C. Sh, S. Kumar, S. Thulkar
Journal: Journal of Clinical Oncology (2008)

19526 Background: Pulmonary involvement of non-Hodgkin’s lymphoma is quite a common condition. There have been a very few reviews of this lymphoma, CT features have not been well defined. Richter’s syndrome (RS) is an uncommon complication of chronic lymphocytic leukemia (CLL) characterized by its transformation into diffuse histiocytic lymphoma. Aim: To characterize computed tomography (CT) features of pulmonary lymphoma and richters syndrome. Methods: The CT scans of pathologically proven 32 patients (men 26, woman 6) of age range from 10–82 years with pulmonary non-Hodgkin’s lymphoma were evaluated for alveolar opacities (lobar consolidation, masses or nodules, and ill-defined consolidations), peribronchial disease or bronchial wall thickening, mediastinal nodes, chest wall involvement, atelectasis, pleural effusion and extra pulmonary sites. Results: Multilobar bilateral, multilobar unilateral and unilobar unilateral involvement was present in 10, 4 and 8 cases respectively. CT features were: Nodular opacities and ground glass opacities (n= 16), Ill-defined consolidation (n=18), lobar consolidation (n = 1), and pleural effusion (n = 12 cases). Peribronchial disease was seen in 8 patients, mediastinal adenopathy in 10 patients, subpleural consolidation (n=8), mass like consolidation, lobar consolidation in two patients each, atelectasis in 6 patients and chest wall involvement in one patient. Richter’s syndrome was seen in one patient. The commonest extra pulmonary involvement was seen in lymph nodes besides liver, spleen, bowel and bone. Conclusion: Pulmonary involvement in lymphoma is characterized by nodular opacities of variable size, ground glass opacities, ill-defined consolidation, peribronchial disease and chest wall involvement are ancillary findings associated with mediastinal adenopathy and extranodal lymphomatous soft tissue lesions. The mass like consolidation in the lung associated with chest wall involvement of acute onset in a patient with chronic lymphocytic leukemia the Diagnosis of Richter’s syndrome should be considered. No significant financial relationships to disclose.
Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZODIAC)
Authors: R. S. Herbst, Y. Sun, S. Korfee, P. Germonpré, N. Saijo, C. Zhou, J. Wang, P. Langmuir, S. J. Kennedy, B. E. Johnson
Journal: Journal of Clinical Oncology (2009)

CRA8003 The full, final text of this abstract will be available in Part II of the 2009 ASCO Annual Meeting Proceedings, distributed onsite at the Meeting on May 30, 2009, and as a supplement to the June 20, 2009, issue of the Journal of Clinical Oncology. [Table: see text]
Prognostic value of changes in quality-of-life scores in prostate cancer.
Authors: D. Gupta, D. P. Braun, E. D. Staren
Journal: Journal of Clinical Oncology (2011)

e15001 Background: Several studies in oncology literature have demonstrated the prognostic value of baseline quality of life (QoL). However, there is little to no information on the prognostic effects of changes in QoL during treatment. We investigated whether changes in QoL could predict survival in prostate cancer. Methods: We evaluated 250 prostate cancer patients treated at our institution between Jan 2001 and Dec 2009 who were available for a minimum follow-up of 3 months. QoL was evaluated at baseline and after 3 months of treatment using EORTC-QLQ-C30. The QLQ-C30 incorporates a global scale, 5 functional scales and 8 symptom scales. Scores range from 0-100 with higher scores in the global and functional scales and lower scores in the symptom scales indicating better QoL. Patient survival was defined as the time between date of first patient visit and date of death from any cause/date of last contact. Cox regression was performed to evaluate the prognostic significance of baseline, 3-month and changes in QoL scores. Change scores were calculated by subtracting baseline from 3-month QoL scores. Results: Mean age at diagnosis was 59.7 years. 149 patients were newly diagnosed at our hospital while 101 were previously treated elsewhere. Patient stage of disease at diagnosis was I, 3; II, 165; III, 31; IV, 48; and 3 indeterminate. Median overall survival was 89.1 months (95% CI: 56.5-121.7). Baseline QoL scales predictive of survival upon multivariate analysis were fatigue (p=0.005) and constipation (p=0.02). 3-month QoL scale predictive of survival upon multivariate analysis was fatigue (p=0.05). Associations between changes in QoL and survival were observed only for dyspnea. Every 10-point increase (worsening) in dyspnea from baseline to 3 months was associated with a 21% increase in death (HR=1.21; 95% CI=1.05 to 1.35, p=0.01). Conclusions: This exploratory study provides some preliminary evidence to indicate that prostate cancer patients with worse baseline and 3-month fatigue and patients whose dyspnea worsens within 3 months of treatment are at significantly increased risk of shorter survival. These findings may be used in clinical practice to systematically address QoL-related problems of cancer patients throughout their treatment course.
Experimental renal failure in the rat modulates cardiac Na,K-ATPase alpha 2 mRNA but not protein.
Authors: J C da Silva, X J Shi, C A Johns, D M Jefferson, S A Grubman, N E Madias, R D Perrone
Journal: Journal of the American Society of Nephrology (1994)

The decreased abundance and enzymatic activity of myocardial Na,K-ATPase have been recognized previously to occur in chronic uremia. However, the activity of the cardiac sodium pump as defined by the uptake of 86Rb is normal. The discrepancies between these findings may have resulted from the inability to distinguish between the different Na,K-ATPase isoforms now known to exist in cardiac muscle. To investigate this question, steady-state levels of Na,K-ATPase alpha and beta mRNA isoforms, alpha 1, alpha 2, and beta 1 protein, and specific high-affinity binding of [3H]ouabain were quantitated in cardiac muscle from uremic and pair-fed, sham-operated control rats. Steady-state levels of alpha 2 and beta 2 mRNA were significantly decreased (percentage of control levels: alpha 2, 48 +/- 10; beta 2, 74 +/- 9; N = 10; P < 0.025) in chronic renal failure without any change in alpha 1, alpha 3, or beta 1 expression. The number of high-affinity [3H]ouabain-binding sites and Na,K-ATPase alpha 1, alpha 2, and beta 1 subunits was not different from control. In acute renal failure, alpha 2 and beta 2 mRNA levels also were significantly decreased (percentage of control levels: alpha 2, 24 +/- 5; beta 2, 44 +/- 8; N = 6; P < 0.001), but there was no change in the level of alpha 3 or beta 1 mRNA, the number of high-affinity [3H]ouabain-binding sites, or the level of Na,K-ATPase alpha 2 and beta 1 subunits.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 11305: Left Ventricular Dysfunction is a Stronger Predictor of Congestive Heart Failure Events Amongst Hispanic Compared to Non-Hispanic Patients
Authors: Eric D Manheimer, Matthew P Liakos, Mario J Garcia, Daniel M Spevack
Journal: Circulation (2013)

Introduction: The Hispanic population is the fastest growing and largest minority group in the United States. Although NIH-funded epidemiological studies are currently evaluating risk factors for c...
Response to docetaxel (D)/carboplatin (C)-based chemotherapy as first- and second-line therapy in patients with metastatic hormone-refractory prostate cancer (HRPC)
Authors: M. Nakabayashi, O. Sartor, S. Jacobus, M. M. Regan, D. K. McKearn, R. W. Ross, P. W. Kantoff, M. Taplin, W. K. Oh
Journal: Journal of Clinical Oncology (2007)

5156 Background: Effective treatment options for HRPC patients are limited. We evaluated efficacy of D/C-based chemotherapy as first- and second-line chemotherapy. Methods: We retrospectively identified all patients with HRPC treated with D/C-based chemotherapy at DFCI. Regimens either included estramustine (EDC) or not (DC). Patients treated with EDC received D 20–70 mg/m 2 q1–4 weeks, E 140mg TID and C AUC 4–6 q 3–4 weeks. Patients treated with DC received D 50–70 mg/m 2 and C AUC 4–5 q 3–4 weeks. PSA declines and measurable response were assessed per PSA Working Group and RECIST criteria, respectively. Time to event from chemotherapy initiation based on Kaplan-Meier method. Results: 58 patients were included: 27 patients received EDC, 35 received DC, and 4 received both regimens. Median age and PSA at initiation of chemotherapy was 58 years (range: 42–78) and 132.6 ng/ml (range: 0.3–5352.5), respectively. Table shows median duration of PSA response and TTP, by regimen. Most patients received EDC as first-line chemotherapy (89%). PSA declines ≥ 50% were observed in 24 patients (88.9%, 95% C.I. 71–98) and PSA declined in all 27 patients by a median of 81.3 % (range 33–100). Of 8 patients with measurable disease (MD), 2 had confirmed PR and 4 had SD. Median survival was 17.5 months (95% C.I. 12.0–24.5). 34 out of 35 patients received DC as ≥ 2 nd line chemotherapy. PSA declines ≥ 50% were seen in 7 DC patients (20%, 95%C.I. 8–37) and PSA declined in 24 patients with a median of 37.7 % (range 2.0–100). Of 15 patients with MD at baseline, one had confirmed CR, one had PR, and 6 patients had SD. Median survival was 14.8 months (95% C.I. 9–19). The most common reversible grade 4 toxicity with either regimen was neutropenia (6.9%). Conclusions: D/C-based chemotherapy is well tolerated and active in HRPC. As first line chemotherapy, EDC demonstrated PSA declines ≥50% in 88.9% of patients. DC was active as ≥ 2 nd -line chemotherapy with PSA declines ≥50% seen in 20%. [Table: see text] No significant financial relationships to disclose.
Massively Parallel Sequencing-Based Clonality Analysis of Synchronous Endometrioid Endometrial and Ovarian Carcinomas
Authors: Anne M. Schultheis, Charlotte K. Y. Ng, Maria R. De Filippo, Salvatore Piscuoglio, Gabriel S. Macedo, Sonia Gatius, Belen Perez Mies, Robert A. Soslow, Raymond S. Lim, Agnes Viale, Kety H. Huberman, Jose C. Palacios, Jorge S. Reis-Filho, Xavier Matias-Guiu, Britta Weigelt
Journal: JNCI Journal of the National Cancer Institute (2015)

Synchronous early-stage endometrioid endometrial carcinomas (EECs) and endometrioid ovarian carcinomas (EOCs) are associated with a favorable prognosis and have been suggested to represent independent primary tumors rather than metastatic disease. We subjected sporadic synchronous EECs/EOCs from five patients to whole-exome massively parallel sequencing, which revealed that the EEC and EOC of each case displayed strikingly similar repertoires of somatic mutations and gene copy number alterations. Despite the presence of mutations restricted to the EEC or EOC in each case, we observed that the mutational processes that shaped their respective genomes were consistent. High-depth targeted massively parallel sequencing of sporadic synchronous EECs/EOCs from 17 additional patients confirmed that these lesions are clonally related. In an additional Lynch Syndrome case, however, the EEC and EOC were found to constitute independent cancers lacking somatic mutations in common. Taken together, sporadic synchronous EECs/EOCs are clonally related and likely constitute dissemination from one site to the other.