tbuckley/cabot-search huggingface dataset:
AB0400 Differences in lipid profiles between mexican sle patients and general population.
Authors: I. J. Colunga, D. A. Galarza-Delgado, F. Góngora-Rivera, D. Vega-Morales, M. A. Garza-Elizondo
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Premature cardiovascular events had been observed in Systemic Lupus Erythematosus (SLE) patients, [1] but the reason for this accelerated process is still debatable. [2] One of the most important conditions, is a proatherogenic lipid profile. [3] In SLE mexicans we do not have enough data about it. <h3>Objectives</h3> To establish the differences in the lipid profiles between Mexican SLE patients and general population. <h3>Methods</h3> Observational, transversal, descriptive and comparative study, between SLE patients and age-sex- matched healthy volunteers. Ethical approved (MI09-007). Full lipid profile (by spectrophotometry) after 14 hours- fast were performed. Total value of cholesterol (LDL, HDL) and triglycerides were analyzed. We also, realized, a sub-analysis, with proaterogenic values of cholesterol (Total cholesterol &gt;200 mg/dl, triglycerides &gt;150 mg/dl, HDL-cholesterol &lt; 45 mg/dl and LDL-cholesterol &gt;100 mg/dl). Results were analyzed by the statistical package SPSS v.17. <h3>Results</h3> 138 full lipid profiles of different subjects were analyzed; 69 with diagnosis of SLE and 69 age-sex healthy volunteers. The main demographic characteristics are detailed in Table 1. We found statistically significant differences between the mean of total cholesterol and LDL. In a posterior sub-analysis did not found significant differences. We detailed the biochemical parameters in Table 2. <h3>Conclusions</h3> We did not found statistical differences in the lipid profiles explaining an increased cardiovascular morbi-mortality in SLE patients compared to healthy volunteers. <h3>References</h3> Thomas GN, Tam LS, Tomlinson B, Li EK. Accelerated atherosclerosis in patients with systemic lupus erythematosus: a review of the causes and possible prevention. Hong Kong Med J. 2002 Feb;8(1):26-32. Bruce IN.’Not only…but also’: factors that contribute to accelerated atherosclerosis and premature coronary heart disease in systemic lupus erythematosus. Rheumatology (Oxford).2005 Dec;44(12):1492-502. Leong KH, Koh ET, Feng PH, Boey ML. Lipid profiles in patients with systemic lupus erythematosus. J Rheumatol 1994; 21(7): 1264-7 <h3>Disclosure of Interest</h3> None Declared
SP0104 How to identify employees with musculoskeletal pain at risk for sick leave
Authors: S.J. Linton
Journal: Annals of the Rheumatic Diseases (2013)

Employees suffering musculoskeletal pain sometimes develop problems that limit their work capacity. Because such pain problems commonly occur and often reside relatively quickly, identifying those who are at risk of pain-related work absence can appear to be exceptionally difficult. Yet, identification is a pillar for addressing the problem early on so as to prevent chronification. And to be sure, helpful intervention programs are available. This talk will focus on how to identify those at risk using validated techniques. Screening for those at risk is about identifying people who are so likely to develop a significant problem in the future that immediate further assessment or intervention is warranted. Thus, it is based on the idea that such a procedure could help us to focus limited resources on those most in need of them. Standardized screening procedures, including the use of short questionnaires, are very helpful. These procedures can help clinicians save time by asking the most pertinent questions. They are also useful in making clinical decisions such as whether to proceed with further assessment. At best, the information y can also be valuable for making decisions about what kind of treatment might be most effective. Two approaches that have been tested sufficiently will be described in more detail. Several studies show that these screening procedures can accurately detect a significant portion of those who are truly at risk although the exact accuracy varies greatly between investigations. Evidence is emerging that many risk factors are evident very early on suggesting that screening procedures might be initiated at the very first health-care visit. In fact, new data show that a risk profile is detectable hours after the injury. While identifying those at risk is an important first step, we also need to consider how cases will be dealt with when recognized. Clear procedures are required to either assess the problem further or provide for intervention directly. While identifying those at risk is an important first step, we also need to consider how cases will be dealt with when recognized. Clear procedures are required to either assess the problem further or provide for intervention directly. <h3>Disclosure of Interest</h3> None Declared
EFFICACY AND SAFETY OF THE NOVEL ORAL ANTICOAGULANTS COMPARED TO WARFARIN IN PATIENTS WITH NON VALVULAR ATRIAL FIBRILLATION
Authors: Ilaria Gagliardi, Teresa Bruni, Elisa Rauseo, Vincenzo Paravati, Francesco Barilla, Concetta Torromeo, Giuseppe Pannarale, Cesare Greco, Michele Schiariti, Carlo Gaudio
Journal: Journal of the American College of Cardiology (2016)
A Common Clinical Conundrum
Authors: William A. Gray, Robert J. DuBroff, Harvey J. White
Journal: New England Journal of Medicine (1997)

A 60-year-old man came to the hospital because of intermittent wheezing, progressive dyspnea on exertion, and severe orthopnea, which had been present for several weeks. The patient had also had occasional vague chest pressure that was not clearly brought on by exertion. In the emergency room, the patient was short of breath while breathing room air; his oxygen saturation was 84 percent. On physical examination his blood pressure was 192/78 mm Hg. He had bibasilar rales, a gallop rhythm, and a right carotid bruit. The electrocardiogram showed no abnormalities, and the chest film demonstrated a normal heart size with . . .
Prognostic Role of 18F-FDG PET/CT in the Postoperative Evaluation of Differentiated Thyroid Cancer Patients
Authors: Leonardo Pace, Michele Klain, Barbara Salvatore, Emanuele Nicolai, Emilia Zampella, Roberta Assante, Teresa Pellegrino, Giovanni Storto, Rosa Fonti, Marco Salvatore
Journal: Clinical Nuclear Medicine (2014)

The aim of this study was to evaluate the role of F-FDG PET/CT performed after surgery but before radioiodine therapy in patients with differentiated thyroid cancer.FDG PET/CT was performed off l-thyroxine in 60 newly diagnosed differentiated thyroid cancer patients. Clinical and hematological evaluation as well as high-resolution neck ultrasound were performed. All patients underwent a complete follow-up (range, 6-67 months; mean [SD], 31.7 [20.6] months). The date of recurrence or the most recent office visit was recorded. Progression-free survival (PFS) is the primary end point of this study. Analysis was performed by Cox proportional hazards model. Survival curves were generated using Kaplan-Meier estimates, and the log-rank test was used to assess significance.FDG PET/CT was negative in 63% of patients, 20% had FDG thyroid bed uptake, 5% distant metastases, and 12% lymph node FDG uptake. In patients with positive FDG PET/CT scan (ie, those with distant metastases or lymph node uptake), a higher rate of recurrence was observed (50% vs 6%, P < 0.05). Thyroglobulin, neck ultrasound, stage, and FDG PET/CT correlated with PFS at univariate analysis. At multivariate analysis, only thyroglobulin and FDG PET/CT continued to be predictors of PFS. Patients with a negative FDG PET/CT scan have a better PFS either in the whole group or in those with elevated thyroglobulin level (both >2 ng/mL and >10 ng/mL).FDG PET/CT was abnormal in 17% of patients. Moreover, FDG PET/CT has an independent prognostic role, with a better PFS in patients with a negative scan.
Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction
Authors: Marc A. Pfeffer, Eugene Braunwald, Lemuel A. Moyé, Lofty Basta, Edward J. Brown, Thomas E. Cuddy, Barry R. Davis, Edward M. Geltman, Steven Goldman, Greg C. Flaker, Marc Klein, Gervasio A. Lamas, Milton Packer, Jacques Rouleau, Jean L. Rouleau, John Rutherford, John H. Wertheimer, C. Morton Hawkins
Journal: New England Journal of Medicine (1992)

Left ventricular dilatation and dysfunction after myocardial infarction are major predictors of death. In experimental and clinical studies, long-term therapy with the angiotensin-converting—enzyme inhibitor captopril attenuated ventricular dilatation and remodeling. We investigated whether captopril could reduce morbidity and mortality in patients with left ventricular dysfunction after a myocardial infarction.
Abstract 2533: Inverse association between circulating vitamin D and mortality - dependent on sex and cause of death.
Authors: Sabine Rohrmann, Julia Braun, Matthias Bopp, David Faeh
Journal: Cancer Research (2013)

Abstract Background: Vitamin D has immune-modulation properties as well as effects on cell differentiation and proliferation, on angiogenesis, but also on blood pressure and glucose tolerance, and in various populations, vitamin D deficiency is associated with chronic diseases and mortality. We examined the association between concentration of circulating 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, with all-cause and cause-specific mortality. Methods: The study included 3191 participants of the general adult Swiss population, who were recruited between November 1988 and June 1989 and followed-up until the end of 2008. Serum 25(OH)D was measured by protein-bound assay. Cox proportional hazards regression was used to examine the association between 25(OH)D concentration and overall and cause-specific mortality adjusting for sex, age, season, diet, nationality, blood pressure, and smoking status. Results: Mean serum 25(OH)D concentration was 19.8 ng/mL in men and 20.5 ng/mL in women. Participants with low 25(OH)D (≤13.4 ng/mL) were more likely to have participated during winter months, but less likely to have spent ≥30 minutes outdoors per day or been on vacation in the month prior to blood collection. Individuals with 25(OH)D concentrations ≥25 ng/mL tended to be less often of foreign nationality, current smokers and more frequently in the upper educational level. During the follow-up period, 459 study participants died (188 of cancer and 122 of cardiovascular diseases). Per 10 ng/mL increase in 25(OH)D concentration, all-cause mortality decreased by 20% (HR=0.83; 95% CI 0.74-0.92). Excluding the first five years of follow-up did not materially affect the observed associations. 25(OH)D concentration was inversely associated with cardiovascular mortality in women (0.68, 0.46-1.00), but not in men (0.97; 0.77-1.23). In contrast, 25(OH)D concentration was inversely associated with cancer mortality in men (0.72, 0.57-0.91), but not in women (1.14, 0.93-1.39). Multivariate adjustment only slightly modified the 25(OH)D-mortality association. Conclusion: 25(OH)D was similarly inversely related to all-cause mortality in men and women. However, we observed opposite effects in women and men with respect to cardiovascular- and cancer-related mortality. Citation Format: Sabine Rohrmann, Julia Braun, Matthias Bopp, David Faeh. Inverse association between circulating vitamin D and mortality - dependent on sex and cause of death. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2533. doi:10.1158/1538-7445.AM2013-2533
COMPARACION DE LIMPIEZA DE COLON CON DISTINTAS PAUTAS Y PREPARADOS. RELACIÓN CON LOS HALLAZGOS ENDOSCÓPICOS
Authors: L Mata Román, M Ibáñez García, B Cantón Álvarez, A Santamaría Martínez, A San José Briz, I Alonso González, V Esteban Aceves, S Maestro Antolín, C Villalón Rico
Journal: Endoscopy (2013)

Introducción: Una colonoscopia de calidad depende de una limpieza previa rigurosa. Es importante encontrar la pauta de limpieza menos molesta pero eficaz para conseguir un buen resultado. Objetivo: Comparar el grado de limpieza y los hallazgos endoscópicos, en función del tipo de preparación y el momento de administración. Material y Método: Estudio de cohortes prospectivo y analítico de pacientes sometidos a colonoscopia entre Marzo 2012 y Abril 2013. Recibieron de forma aleatorizada Polietilenglicol (PEG) 2litros (PEG2) o fosfato sódico (PS), tomando o toda la preparación el día anterior o toda la preparación 6 horas antes o dosis fraccionada con la mitad de dosis el día anterior y el resto 6h antes de la prueba. Se valoró la tolerancia a las preparaciones y el grado de limpieza de colon con escalas validadas. Resultados: Se incluyeron 944 pacientes; 61.2% recibieron PEG2, 34.7% PS. 41% se prepararon el día anterior, 24.3% el mismo día y 34.7% hicieron preparación fraccionada. Se detectaron mayor número de lesiones cancerosas en pacientes que tomaron fraccionada de la preparación, 54.3% de las neoplasias (p = 0.007). No hubo relación entre el agente de preparación y los hallazgos endoscópicos. El 84.7% (60.3% dosis fraccionada) de los casos con mejor limpieza (puntuación 0) recibieron al menos parte de la preparación el mismo día de la prueba (p < 0.000). El 64.3% de los casos con peor grado de limpieza (puntuación12) habían tomado toda la preparación el día anterior (p < 0.000). No se encontró relación significativa entre la puntuación en la escala y el agente de preparación tomada. Presentaron mejor tolerancia a la preparación PEG2 (p = 0.003), sin relación estadística con el momento de administración. Conclusiones: La preparación en dosis fraccionada consigue mejor limpieza de colon y mayor detección de lesiones avanzadas, sin relación con el agente empleado.
Heterogeneity in the Effects of Reward- and Deposit-based Financial Incentives on Smoking Cessation
Authors: Scott D. Halpern, Benjamin French, Dylan S. Small, Kathryn Saulsgiver, Michael O. Harhay, Janet Audrain-McGovern, George Loewenstein, David A. Asch, Kevin G. Volpp
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Targeting different smoking cessation programs to smokers most likely to quit when using them could reduce the burden of lung disease.To identify smokers most likely to quit using pure reward-based financial incentives or incentive programs requiring refundable deposits to become eligible for rewards.We conducted prespecified secondary analyses of a randomized trial in which 2,538 smokers were assigned to an $800 reward contingent on sustained abstinence from smoking, a refundable $150 deposit plus a $650 reward, or usual care.Using logistic regression, we identified characteristics of smokers that were most strongly associated with accepting their assigned intervention and ceasing smoking for 6 months. We assessed modification of the acceptance, efficacy, and effectiveness of reward and deposit programs by 11 prospectively selected demographic, smoking-related, and psychological factors. Predictors of sustained smoking abstinence differed among participants assigned to reward- versus deposit-based incentives. However, greater readiness to quit and less steep discounting of future rewards were consistently among the most important predictors. Deposit-based programs were uniquely effective relative to usual care among men, higher-income participants, and participants who more commonly failed to pay their bills (all interaction P values < 0.10). Relative to rewards, deposits were more effective among black persons (P = 0.022) and those who more commonly failed to pay their bills (P = 0.082). Relative to rewards, deposits were more commonly accepted by higher-income participants, men, white persons, and those who less commonly failed to pay their bills (all P < 0.05).Heterogeneity among smokers in their acceptance and response to different forms of incentives suggests potential benefits of targeting behavior-change interventions based on patient characteristics. Clinical trial registered with www.clinicaltrials.gov (NCT 01526265).
Abstract 5214: Role of mitogen-activated protein kinase (ERK) signaling in cyclooxygenase 2-mediated colon cancer cell migration
Authors: Kara Hessel, Ronald R. Bean, Rolf Jakobi, Yu-Wen E. Chang
Journal: Cancer Research (2010)

Abstract Colon cancer is the second most common cause of cancer-related deaths. Many patients present with colon cancer in advanced stages of metastasis, where the outcome is poor and mortality is high. Invasion is an essential capability acquired by cancer cells to metastasize to distant organs. Currently there are no effective strategies to prevent invasion because the underlying mechanisms are poorly understood. During early development of colon cancer, cyclooxygenase 2 (COX-2) is constitutively induced. We have shown that COX-2 promotes invasion by disrupting cell adhesion and increasing motility in HCA-7 colon cancer cells that constitutively express endogenous COX-2. To further determine the mechanisms by which COX-2 stimulates motility and to confirm this cellular behavior in other colon epithelial cells, we established HCT-15 colon cancer cells that stably express recombinant COX-2 (HCT-15-COX-2). Scratch wound gap assays were used to monitor cell motility and proliferation in HCA-7 and HCT-15-COX-2 cells. HT-29 colon cancer cells that do not express COX-2 and parental HCT-15 cells were used as controls. HCA-7 and HCT-15-COX-2 cells closed the gap significantly faster than HT-29 and HCT-15 cells. Inhibition of COX-2 in HCA-7 and HCT-15-COX-2 cells by the COX-2 selective inhibitor NS-398 decreased the gap closing. Interestingly, the enhanced gap closing ability of HCA-7 and HCT-15-COX-2 cells correlated with activation of ERKs, mitogen-activated protein kinases that are known to mediate COX-2 signaling to stimulate colon cancer cell growth. Activation of ERK depended on COX-2 activity. Inhibition of ERK signaling in HCA-7 and HCT-15-COX-2 cells reduced gap closing as effectively as NS-398. Furthermore, inhibition of ERK signaling prevented migration of both HCA-7 and HCT-15-COX-2 cells in modified Boyden chamber assays. Interestingly, reduced migration by inhibition of ERK signaling correlated with increased protein levels of adherens junction protein alpha-catenin. Our data reveal for the first time a role for ERK to promote cell migration in response to COX-2 signaling in addition to its stimulation of cancer cell growth. Since cardiovascular toxicity caused by long-term use of COX-2 inhibitors raises several concerns, targeting ERK can be an alternative approach for preventing colon cancer growth and invasion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5214.
Abstract 3084: miR509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF alpha.
Authors: Fei Xing, Hiroshi Okuda, Aya Kobayashi, Puspa R. Pandey, Sambad Sharma, Yin-Yuan Mo, Yin Liu, Kerui Wu, Kounosuke Watabe
Journal: Cancer Research (2013)

Abstract Brain metastasis of breast cancer profoundly affects the cognitive and sensory functions as well as morbidity of patients, and the rate of one year survival among these patients remains less than 20%. Because of the location of metastatic lesions, a surgical approach is limited and most chemotherapeutic drugs are ineffective due to the blood brain barrier (BBB). Despite this clinical importance, the molecular basis of breast tumor metastasis to the brain is poorly understood. Recent active research in microRNA identified a series of this type of molecules that are involved in tumor progression in various tumors as oncogenes and tumor suppressors. In this study, we have isolated RNA from Formalin-Fixed Paraffin-Embedded (FFPE) samples obtained from primary breast tumors and also from brain metastatic lesions followed by microRNA profiling. The results of our profile analysis for these samples revealed that primary tumor samples expressed significantly high level of miR509 compared to brain metastatic lesions. We also found that this microRNA was capable of modulating two essential genes for invasion, RhoC and TNF alpha. Interestingly, high expression of TNF alpha was significantly and inversely correlated to brain metastasis-free survival of breast cancer patients. Importantly, we found that the expression of miR509 significantly suppressed the ability of cancer cells to metastasize to the brain in our animal model. We also examined the expression of TNF alpha in brain-metastatic lesions and found that it was indeed significantly up-regulated. Furthermore, the results of our in vitro experiments indicate that miR509 attenuates the abilities of invasion of breast cancer cells by modulating the RhoC expression. These results suggest that miR509 may serve as a biomarker or therapeutic targets for brain metastasis of breast cancer. Citation Format: Fei Xing, Hiroshi Okuda, Aya Kobayashi, Puspa R. Pandey, Sambad Sharma, Yin-Yuan Mo, Yin Liu, Kerui Wu, Kounosuke Watabe. miR509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF alpha. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3084. doi:10.1158/1538-7445.AM2013-3084 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
HOSPITALIZATIONS, RECURRENT VENOUS THROMBOEMBOLISM OR VENOUS THROMBOEMBOLISM-RELATED DEATH, AND MAJOR BLEEDING, BY INDEX EVENT FROM THE AMPLIFY TRIAL
Authors: Theodore Lee, Cristina Masseria, Andrei Breazna, Gregory DiRusso, Melissa Hamilton, Ruslan Horblyuk, Jack Mardekian, Anthony Porcari, Alexander (Ander) Cohen
Journal: Journal of the American College of Cardiology (2016)
Unusual Pattern of Extraskeletal Tc-99m MDP Uptake in Traumatic Crushing Muscle Injury
Authors: S T Lim, M H Sohn
Journal: Clinical Nuclear Medicine (2001)

From the Department of Nuclear Medicine* and Institute for Medical Sciences,† Chonbuk National University Medical School, Chonju, Korea Received for publication December 11, 2000. Accepted January 20, 2001. Supported by Korea Research Foundation grant KRF-99-041-F00273. Reprint requests: Myung-Hee Sohn, Department of Nuclear Medicine, Chonbuk National University Medical School, 634–18 Keumam-dong, Duckjin-gu, Chonju, Chonbuk 561–182, Korea. E-mail: [email protected]
Lack of Association between Cirrhosis and the Common Types of Color Blindness
Authors: Philip J. Fialkow, Horace C. Thuline, L. Frederick Fenster
Journal: New England Journal of Medicine (1966)

A RELATIVELY large number of color-vision abnormalities have recently been observed in alcoholic patients with cirrhosis, and the suggestion has been advanced that the X-linked genes causing color blindness predispose to cirrhosis of the liver in alcoholic patients1 and to alcoholism.2 To investigate this relation further, a group of alcoholic patients with cirrhosis in Seattle was studied for color-vision defects.Materials and MethodsTwenty-two female and 24 male alcoholic patients with Laennec's cirrhosis were studied. Forty-two were white, and 4 were Negroes. All had the typical clinical and laboratory findings of Laennec's cirrhosis, and 26 had histologic confirmation of the . . .
P1249 CFTR CONTROLS A MEMBRANE MULTI-PROTEIN COMPLEX THAT REGULATES CHOLANGIOCYTE C-SRC TYROSINE KINASE ACTIVITY AND TLR4 SIGNALING: IMPLICATIONS FOR CYSTIC FIBROSIS LIVER DISEASE (CFLD)
Authors: R. Fiorotto, A. Villani, R. Scirpo, C. Spirli, M. Strazzabosco
Journal: Journal of Hepatology (2014)