tbuckley/cabot-search huggingface dataset:
Imported aseptic meningitis due to Toscana virus acquired on the island of Elba, Italy, August 2008
Authors: B Sonderegger, H Hächler, G Dobler, M Frei
Journal: Eurosurveillance (2009)

We describe a case of aseptic meningitis due to Toscana Virus imported to Switzerland and discuss the epidemiological situation. To our knowledge this is the first description of this infection acquired on the Island of Elba.
Benefits of female “libido” drug flibanserin are marginal, systematic review finds
Authors: Michael McCarthy
Journal: BMJ (2016)

Additional research is needed before the female “libido” drug flibanserin can be recommended for treatment of low sexual desire in women, the authors of a new systematic review and meta-analysis have concluded.1

The benefits of the drug are “marginal,” they said, and treatment was associated with clinically significant adverse events.

“Before flibanserin can be recommended in guidelines and clinical practice, future studies should include women from diverse populations, particularly women with (a history of) somatic and psychological comorbidities, medication use, and surgical menopause,” wrote the lead author, Loes Jaspers, of Erasmus University Medical Center in Rotterdam, Netherlands, and …
Abstract 131: Differential Regulation of Pitx2 Expression in Pulmonary Vein Muscle Sleeves and Left Atrium with Aging: Implication for Pulmonary Vein Triggers
Authors: Johnson Wong, Div Verma, Craig Selzman, Huei-sheng Vincent Chen
Journal: Circulation Research (2012)

Introduction: Pitx2, Paired-like homeodomain transcription factor 2, is a homeobox transcription factor that regulates left-right asymmetry during cardiogenesis. Pitx2 insufficiency in the left atrium (LA) has been linked to LA remodeling and arrhythmogenesis in age-related atrial fibrillation (AF). However, the main triggers for AF reside in pulmonary vein muscle sleeves (PVs). Whether Pitx2 insufficiency in PVs also plays a pathogenic role in generating trigger foci remains to be determined. Also, changes in Pitx2 expression in PVs with age remain unclear. We use qRT-PCR and Illumina microarrays to determine age-related changes in Pitx2 expression of PVs in wild type (WT) &amp; heterozygous Pitx2cnull+/- mice, and in humans with or without AF. Methods: PV and LA regions were obtained from 1-23 month-old WT and Pitx2cnull+/- mice. Human PVs were obtained from ~110D human fetal hearts (E110D aborted fetus), two groups of adult donor hearts [20-30s year-old (yo) and 40-50 yo] and two patients with persistent AF. These tissues were used for genetic expression analysis. Results: Pitx2c expression decreases slightly with age in mouse LA and PV tissues. The expression levels of Pitx2c of Pitx2cnull+/- mice in LA are consistently at 55.2±10.5% of WT but at near-equal levels in PVs over four different age groups. In contrast, during human development, Pitx2 expression in PV muscle sleeves first decreases from ~E110D to ~30 yo but increases from 30 to 50 yo. In patients with AF, Pitx2 expression in PVs is only lower by 15% while HCN4 expression is higher by 13.5% when compared to control PVs at &gt;50 yo. Expressions of type 2 Ryanodine receptors and calsequestrin in human PVs increase with age but decrease by ~30% with AF, suggesting impaired calcium handling abilities may play more significant roles than Pitx2 in the generation of PV triggers of AF. Conclusions: Genetic analysis of Pitx2c expression in PV muscle sleeves and LA tissues of WT and Pitx2cnull+/- mice revealed differential expression patterns. In human PVs, Pitx2 expression shows a regulation pattern with age distinct from that in mice, and genes linked to intracellular calcium handling may play a more important role than Pitx2 in generating trigger foci in PVs to initiate AF.
Catch-up alveolar development into adulthood: also in those born prematurely?
Authors: Peter J.F.M. Merkus
Journal: European Respiratory Journal (2016)

The way the human lung grows post-natally has intrigued many of us and many of our predecessors, and still does. Originally exclusively based on post mortem findings, it was concluded that a large variability in number of alveoli exists between humans and that this wide scatter is present not only at birth but also in childhood [1, 2]. From these cross-sectional anatomical studies, it could not be inferred whether catch-up (increase of alveolar numbers) is possible, whether interindividual differences in longitudinal growth patterns exist and when physiological alveolar multiplication ends. Classically, many authors assumed that new alveoli are formed up to at least 8 years of age [3, 4] but from the largest morphometric study, it was concluded that the number of alveoli in both sexes increased little or not at all after the age of 2 years [2]. The hypothesis was that thereafter, further lung growth consists of dimensional growth of alveoli only. Similar growth patterns were assumed to exist in post-pneumectomy compensatory lung growth, with very little indication that multiplication occurs in adolescence or thereafter [5]. Obviously, to study the alveolar increase during growth, other techniques should be used. The window of possible catch-up alveolarisation seems quite large: good news for the young and the old <http://ow.ly/WNPIV>
Childless by choice: a clinical study
Authors: N B Kaltreider, A G Margolis
Journal: American Journal of Psychiatry (1977)

The authors report on a longitudinal study that involved the interviewing and testing of 33 young women volunteers who chose either contraception (N=18) or tubal ligation (N=15) to achieve infertility. They found that for these women the choice to be childless was multidetermined, persistent over time, and ego-syntonic. Comparison with other samples of women indicate that this is a distinct and nontraditional population.
Comparison of 3 type VII collagen (C7) assays for serologic diagnosis of epidermolysis bullosa acquisita (EBA)
Authors: Vannina Seta, Françoise Aucouturier, Jonathan Bonnefoy, Christelle Le Roux-Villet, Valérie Pendaries, Marina Alexandre, Sabine Grootenboer-Mignot, Michel Heller, Nicole Lièvre, Liliane Laroche, Frédéric Caux, Matthias Titeux, Alain Hovnanian, Catherine Prost-Squarcioni
Journal: Journal of the American Academy of Dermatology (2016)
Sera of patients with infantile eosinophilic gastroenteritis showed a specific increase in both thymic stromal lymphopoietin and IL-33 levels
Authors: Tetsuo Shoda, Akio Matsuda, Katsuhiro Arai, Hirotaka Shimizu, Hideaki Morita, Kanami Orihara, Naoko Okada, Masami Narita, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto, Ichiro Nomura
Journal: Journal of Allergy and Clinical Immunology (2016)
Long-term pamidronate in multiple myeloma.
Authors: J F Seymour
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.7.2572 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9667282 Long-term pamidronate in multiple myeloma. J F SeymourxJ F SeymourSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.7.2572 PDF "Long-term pamidronate in multiple myeloma.." Journal of Clinical Oncology, 16(7), pp. 2572–2573© 1998 by American Society of Clinical Oncology
Abstract 319: Prehospital Indication of Reperfusion in STEMI Patients and 1-Month Mortality
Authors: Fernando Rosell, Francisco J Mellado-Vergel, Francisco Rivas-Ruiz
Journal: Circulation (2012)

The indication of reperfusion at first medical contact (RFMC), proceeding directly to Cath-Lab (DCL) or, if not possible, performing pre-hospital thrombolisys on site (PhT), is a key action for STEMI patients. Our objective is to analyse if changes in RFMC are associated with one-month mortality in STEMI patients. Methods: Retrospective observational study of two periods, P1 (Jan2001-Dec03) and P2 (Jan2005-May2009), from a continuous pre-hospital registry of patients with STEMI. Patients were followed up in-hospital and one month later. Univariate analysis to compare both periods and logistic regression for one-month mortality (from in-hospital admission to one month later). Results: Total patients included 5522 (2248 P1 and 3274 P2). Univariate analysis (P1 vs P2) found significant differences in (%): age (64.3 vs 63.5, p=0.032), dyslipidemia (33.6 vs 36.7, p=0.02), hypertension (48.4 vs 53.1, p=0.01), history of angina (14.9 vs 11.1, p&lt;0.0001), history of AMI (16.4 vs 13, p=0.001), hypotension (systolic blood pressure&lt;90 mm Hg) (15.2 vs 13.3, p=0.049), Killip&gt;I (19 vs 12.7, p&lt;0.0001), onset-symptoms-call &lt;60 min. (56.5 vs 60.1, p=0.01), PhT (20.8 vs 40.4, p&lt;0.0001), DCL (0 vs 7.1, p&lt;0.0001), in-hospital thrombolysis (46.8 16.4, p&lt;0.0001) primary PCI (4.1 vs 17.5, p&lt;0.0001), rescue PCI (4.3 vs 12, p&lt;0.0001), PCI during hospital admission (16.9 vs 29.8, p&lt;0.0001), RFMC (20.8 vs 47.5, p&lt;0.0001),one-month mortality (18.8 vs 13.8 p&lt;0.0001). The logistic regression in table 1. After adjust for clinical conditions and any PCI treatment preformed, RFMC was associated with less one-month mortality. Conclusions: There were significant increases of RFMC and percentages of PCI throughout the process in P2. Despite the fact of worst clinical conditions of P1 patients, one-month mortality decreased in P2. RFMC was associated to one-month mortality reduction in STEMI patients.
Phleomycin Stimulation of Thymidine Triphosphate Incorporation by Animal Cell Nuclei
Authors: Robert M. Friedman, Robert Stern, James A. Rose
Journal: JNCI Journal of the National Cancer Institute (1974)

Phleomycin stimulated the incorporation of thymidine triphosphate (TTP} into DNA in isolated nuclei from several animal cell lines; however, phleomycin also induced degradation of nuclear DNA as detected by alkaline sucrose density gradient centrifugation. The stimulation of TTP incorporation by phleomycin required Mg2+ and deoxynucleoside triphosphates. Phleomycin activity also had marked heat stability. It is suggested that stimulation of TTP incorporation by phleomycin is related to an increase in DNA synthetic activity secondary to extensive strand breakage induced by the drug.
Aflibercept is better drug for diabetic macular oedema, study finds
Authors: Jacqui Wise
Journal: BMJ (2016)

Three drugs to treat diabetic macular oedema—aflibercept, bevacizumab, and ranibizumab—are equally effective for patients with mild vision loss, a two year trial funded by the US National Institutes of Health shows. However, for patients with moderate or worse vision loss aflibercept produced the greatest gains, the study published in Ophthalmology showed.1

All three drugs inhibit vascular endothelial growth factor, a substance that can promote abnormal blood vessel growth and leakage that leads to blurred vision. Although the drugs have a similar mode of action, they differ substantially in cost. In the United States aflibercept costs $1850 (£1330; €1680) for an injection, bevacizumab $60, and ranibizumab $1200. In the United Kingdom the National Institute for Health and Care Excellence has recommended only aflibercept and …
Tracking Down Response and Resistance to TRK Inhibitors
Authors: Ross A. Okimoto, Trever G. Bivona
Journal: Cancer Discovery (2016)

Abstract Summary: Two recent studies validate the LMNA–NTRK1 fusion as an oncogenic driver and therapeutic target of TRK inhibitors. The LMNA–NTRK1 fusion occurs at low frequency across multiple tumor types. The studies highlight the increasing need to develop molecular biomarker–based clinical trials across cancer subtypes.Cancer Discov; 6(1); 14–6. ©2016 AACR. See related article by Russo et al., p. 36.
Abstract 282: Functional Analysis Of Micrornas In Vascular Disease
Authors: Shusheng Wang, Qinbo Zhou, Chastain Anderson
Journal: Circulation Research (2014)

microRNAs (miRNA, miR) are emerging as pivotal modulators of vascular development and disease. Research is my lab is focused on elucidating the functional mechanism and exploring therapeutic potential of microRNAs in vascular diseases. Our recent studies have shown that miR-23 and miR-27 in miR-23~27~24 family are required for proper angiogenesis and neovascularization in a laser-induced vascular injury model. Here we extend our study and provide evidence that miR-24 regulates actin dynamics in ECs through targeting multiple members downstream of Rho signaling, including Pak4, Limk2 and Diaph1 proteins. Consistent with the critical role for actin cytoskeleton in cell motility and proliferation, overexpression of miR-24 in ECs blocks stress fiber and lamellipodia formation, represses EC migration, proliferation and tube formation in vitro, as well as angiogenesis in an ex vivo aortic ring assay. Overexpression of miR-24 in transgenic mice represses postnatal retinal vascular development. Moreover, subretinal delivery of miR-24 mimics represses laser-induced CNV in vivo. Mechanistically, knockdown of miR-24 target protein LIMK2 or PAK4 inhibits stress fiber formation and tube formation in vitro, mimicking miR-24 overexpression phenotype in angiogenesis. Taken together, these findings demonstrate that miR-24 represses angiogenesis by simultaneously regulating multiple components in the actin cytoskeleton pathways, suggesting distinct function of miR-23~27~24 family members in angiogenesis. Manipulation of actin cytoskeleton pathways by miR-24 may represent an attractive therapeutic solution for numerous vascular diseases.
Association Between Having a Highly Educated Spouse and Physician Practice in Rural Underserved Areas
Authors: Douglas O. Staiger, Samuel M. Marshall, David C. Goodman, David I. Auerbach, Peter I. Buerhaus
Journal: JAMA (2016)

This study uses US census and national survey data to investigate the proportion of married physicians who have highly educated spouses, and the odds of the couple living and working in rural underserved areas.
Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways
Authors: Melissa Ingram, Emily A.L. Wozniak, Lisa Duvick, Rendong Yang, Paul Bergmann, Robert Carson, Brennon O’Callaghan, Huda Y. Zoghbi, Christine Henzler, Harry T. Orr
Journal: Neuron (2016)
Deficiency in Maturation Process of Macrophages in Human Cancer&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: E C Krishnan, C D Menon, L Krishnan, W R Jewell
Journal: JNCI Journal of the National Cancer Institute (1980)

Peripheral blood mononuclear cells were cultured from normal individuals and patients with cancer. The analysis of these results indicated a lower number of macrophage precursors (monocytes) in patients with cancer as compared to the number in normal individuals. The macrophage yield was 1.9 +/- 1.1 X 10(4)/ml of blood in patients with cancer versus 7.2 +/- 2.0 X 10(4)/ml of blood in normal individuals. This low yield of macrophages in patients with cancer was not associated with serum factors. Furthermore, a study of the adherent cell population suggests in intrinsic defect in the maturation process in vitro in patients with cancer.
Population-wide Impact of Long-term Use of Aspirin and the Risk for Cancer
Authors: Yin Cao, Reiko Nishihara, Kana Wu, Molin Wang, Shuji Ogino, Walter C. Willett, Donna Spiegelman, Charles S. Fuchs, Edward L. Giovannucci, Andrew T. Chan
Journal: JAMA Oncology (2016)

<h3>Importance</h3> The US Preventive Services Task Force recently recommended the use of aspirin to prevent colorectal cancer and cardiovascular disease among many US adults. However, the association of aspirin use with the risk for other cancer types and the potential population-wide effect of aspirin use on cancer, particularly within the context of screening, remain uncertain. <h3>Objectives</h3> To examine the potential benefits of aspirin use for overall and subtype-specific cancer prevention at a range of doses and durations of use and to estimate the absolute benefit of aspirin in the context of screening. <h3>Design, Setting, and Participants</h3> Two large US prospective cohort studies, the Nurses’ Health Study (1980-2010) and Health Professionals Follow-up Study (1986-2012), followed up 135 965 health care professionals (88 084 women and 47 881 men, respectively) who reported on aspirin use biennially. The women were aged 30 to 55 years at enrollment in 1976; the men, aged 40 to 75 years in 1986. Final follow-up was completed on June 30, 2012, for the Nurses’ Health Study cohort and January 31, 2010, for the Health Professionals Follow-up Study cohort, and data were accessed from September 15, 2014, to December 17, 2015. <h3>Main Outcomes and Measures</h3> Relative risks (RRs) for incident cancers and population-attributable risk (PAR). <h3>Results</h3> Among the 88 084 women and 47 881 men who underwent follow-up for as long as 32 years, 20 414 cancers among women and 7571 cancers among men were documented. Compared with nonregular use, regular aspirin use was associated with a lower risk for overall cancer (RR, 0.97; 95% CI, 0.94-0.99), which was primarily owing to a lower incidence of gastrointestinal tract cancers (RR, 0.85; 95% CI, 0.80-0.91), especially colorectal cancers (RR, 0.81; 95% CI, 0.75-0.88). The benefit of aspirin on gastrointestinal tract cancers appeared evident with the use of at least 0.5 to 1.5 standard aspirin tablets per week; the minimum duration of regular use associated with a lower risk was 6 years. Among individuals older than 50 years, regular aspirin use could prevent 33 colorectal cancers per 100 000 person-years (PAR, 17.0%) among those who had not undergone a lower endoscopy and 18 colorectal cancers per 100 000 person-years (PAR, 8.5%) among those who had. Regular aspirin use was not associated with the risk for breast, advanced prostate, or lung cancer. <h3>Conclusions and Relevance</h3> Long-term aspirin use was associated with a modest but significantly reduced risk for overall cancer, especially gastrointestinal tract tumors. Regular aspirin use may prevent a substantial proportion of colorectal cancers and complement the benefits of screening.
Estrogen receptor versus nuclear grade as prognostic factors in axillary node negative breast cancer.
Authors: W L McGuire
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.7.1071 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3392560 Estrogen receptor versus nuclear grade as prognostic factors in axillary node negative breast cancer. W L McGuirexW L McGuireSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.7.1071 PDF "Estrogen receptor versus nuclear grade as prognostic factors in axillary node negative breast cancer.." Journal of Clinical Oncology, 6(7), pp. 1071–1072© 1988 by American Society of Clinical Oncology
[472] INDUCTION OF POTENT AND LONG LASTING CD4 AND CDS T-CELL RESPONSES AGAINST HEPATITIS C VIRUS BY IMMUNIZATION WITH VIRAL ANTIGENS PLUS POLY(I:C) AND ANTI-CD40
Authors: A. Zabaleta, L. Arribillaga, D. Llopiz, J. Dotor, T.J. Lasarte, J. Prieto, F. Borras-Cuesta, J.I. Esteban, I. Quer, F. Vayreda, P. Sarobe
Journal: Journal of Hepatology (2007)
Pulmonary Valve Replacement After Repair of Pulmonary Stenosis Compared With Tetralogy of Fallot
Authors: Jouke P. Bokma, Michiel M. Winter, Thomas Oosterhof, Hubert W. Vliegen, Arie P. van Dijk, Petronella G. Pieper, Folkert J. Meijboom, Maarten Groenink, Barbara J.M. Mulder, Berto J. Bouma
Journal: Journal of the American College of Cardiology (2016)
Abstract P253: Body Mass Index and Heart Failure among Patients with Type 2 Diabetes
Authors: Gang Hu, Peter Katzmarzyk, Ronald Horswell, Yujie Wang, Jolene Johnson, Weiqi Li
Journal: Circulation (2015)

Background: Epidemiologic data on the association between body mass index (BMI) and heart failure (HF) risk among diabetic patients is rare. Aim: To investigate the association between BMI and HF risk among patients with type 2 diabetic in the Louisiana State University Hospital-based Longitudinal study (LSUHLS). Methods: We performed a prospective cohort study of risk for HF among 31,155 patients of type 2 diabetes (11,468 men and 19,687 women). Cox proportional hazards regression models were used to estimate the association of different levels of BMI with HF risk. Results: During a mean follow-up of 7.8 years, 5,834 subjects developed HF (2,379 men and 3,455 women). The multivariable-adjusted (age, race, smoking, income and type of insurance) hazard ratios of HF associated with BMI levels (18.5-22.9, 23-24.9, 25-29.9 [reference group], 30-34.9, 35-39.9, and ≥40 kg/m2) at baseline were 0.95, 1.00, 1.00, 1.16, 1.64, and 2.02 (Ptrend &lt;0.001) for men, and 1.16, 1.16, 1.00, 1.23, 1.55, and 2.01 (Pnon-linear &lt;0.001) for women, respectively. When we used an updated mean value of BMI, the association of HF risk with BMI did not change. When stratified by age, race, smoking status and use of anti-diabetic drugs, the positive association among men and the J-shaped association among women were still present. Conclusions: Our study suggests a positive association between BMI and HF risk among men, and a J-shaped association between BMI and HF risk among women with type 2 diabetes.
Abstract P036: Socioeconomic Status and Risk of Diabetes over 35 Years
Authors: Lena M Bjorck, Christina Stahl-Heden, Masuma Novak, Wai Giang Kok, Annika Rosengren
Journal: Circulation (2012)

Background and aim: The link between low socioeconomic status (SES) and CHD is well established but whether low SES is also an independent predictor for development of diabetes type 2 is not clear. The aim of this study was to investigate whether SES, measured as occupational class, predicted subsequent development of diabetes type 2 over an extended follow-up. Methods: A total of 6941 men 47-55 years old, without prior diabetes, from a population sample of 9998 men, were investigated during 1970-73. Of the men, 23.7% were unskilled workers, 27.2% were skilled workers, 19.7% occupied either a supervisory manual position or were lower officials, 17.9% were officials at an intermediate position, and 11.6% were professionals, executives or senior officials. Follow-up was achieved through the national Swedish patient registry. Results: A total of 900 men (13%) were registered at any time with a diagnosis of diabetes over a 35-year follow-up. Compared with men in the highest occupational class, men with intermediate non-manual occupations had a multiple-adjusted hazard ratio (HR) of 1.10, 95% confidence interval (CI) 0.84-1.44, lower officials and foremen had an HR of 1.37 (1.06-1.78), semiskilled and skilled workers 1.39 (1.08-1.78), and unskilled workers 1.66 (1.30-2.13) after adjustment for smoking at baseline, BMI, blood pressure, serum cholesterol, treatment for hypertension and leisure time physical activity. Conclusions: Low SES is an independent risk factor for long-term risk of diabetes in men, with a 66% independent higher risk in unskilled workers, compared to professionals/senior officials.
Screening for Rheumatic Heart Disease in Eastern Nepal
Authors: Bongani M. Mayosi
Journal: JAMA Cardiology (2016)

Nikesh R. Shrestha, MD; Prahlad Karki, MD; Rajan Mahto, MBBS; Keshar Gurung, MD; Naveen Pandey, MD; Krishna Agrawal, MD; Martina Rothenbühler, MSc; Philip Urban, MD; Peter Jüni, MD; Thomas Pilgrim, MD
Comparative Study of Protein Biosynthesis in Mice Susceptible and Resistant to Breast Cancer
Authors: N. A. Sheth, S. V. Bhide
Journal: JNCI Journal of the National Cancer Institute (1973)

Sequential studies on rates of protein biosynthesis in breast, liver, and tumor tissues of C3H/J mice were compared to those on protein biosynthesis in breast and liver tissues of C57BL mice corresponding in age. In the C3H/J strain, the rate of incorporation of 14C-leucine into proteins of breast and liver tissues increased with age and was higllest in the mammary tumor. The breast tissue of the C3H/J strain was more sensitive to hormonal variations than that of the resistant C57BL strain.