tbuckley/cabot-search huggingface dataset:
Specificity of Heteroantisera Developed Against Purified Populations of Intact Murine Ovarian Carcinoma Cells23
Authors: R. C. Bast, R. C. Knapp, V. C. Donahue, J. G. Thurston, A. K. Mitchell, M. Feeney, S. F. Schlossman
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Specificity of Heteroantisera Developed Against Purified Populations of Intact Murine Ovarian Carcinoma Cells Get access R. C. Bast, Jr., R. C. Bast, Jr. 4Division of Tumor Immunology, Sidney Farber Cancer Institute, 44 Binney St., Boston, Mass. 02115. 5Leukemia Society of America Scholar. Previously supported by National Research Service Award 5T32 CA09172-02 from the National Cancer Institute. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. C. Knapp, R. C. Knapp 6Division of Gynecology, Boston Hospital for Women, Boston, Mass. 01742. 7Division of Gynecology, Sidney Farber Cancer Institute. 8Joint Center for Radiation Therapy, Harvard Medical School, 50 Binney St., Boston, Mass. 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar V. C. Donahue, V. C. Donahue 6Division of Gynecology, Boston Hospital for Women, Boston, Mass. 01742. 7Division of Gynecology, Sidney Farber Cancer Institute. 8Joint Center for Radiation Therapy, Harvard Medical School, 50 Binney St., Boston, Mass. 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. G. Thurston, J. G. Thurston 6Division of Gynecology, Boston Hospital for Women, Boston, Mass. 01742. 7Division of Gynecology, Sidney Farber Cancer Institute. 8Joint Center for Radiation Therapy, Harvard Medical School, 50 Binney St., Boston, Mass. 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. K. Mitchell, A. K. Mitchell 6Division of Gynecology, Boston Hospital for Women, Boston, Mass. 01742. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Feeney, M. Feeney 4Division of Tumor Immunology, Sidney Farber Cancer Institute, 44 Binney St., Boston, Mass. 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar S. F. Schlossman S. F. Schlossman 4Division of Tumor Immunology, Sidney Farber Cancer Institute, 44 Binney St., Boston, Mass. 02115. 6Division of Gynecology, Boston Hospital for Women, Boston, Mass. 01742. 7Division of Gynecology, Sidney Farber Cancer Institute. 8Joint Center for Radiation Therapy, Harvard Medical School, 50 Binney St., Boston, Mass. 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 64, Issue 2, February 1980, Pages 365–372, https://doi.org/10.1093/jnci/64.2.365 Published: 01 February 1980 Article history Received: 18 April 1979 Accepted: 27 July 1979 Published: 01 February 1980
PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin–cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer—outcome on prognosis
Authors: M. Untch, G. von Minckwitz, G.E. Konecny, U. Conrad, W. Fett, C. Kurzeder, H.-J. Lück, E. Stickeler, H. Urbaczyk, B. Liedtke, M.W. Beckmann, C. Salat, N. Harbeck, V. Müller, M. Schmidt, S. Hasmüller, M. Lenhard, V. Nekljudova, A. Lebeau, S. Loibl, P.A. Fasching
Journal: Annals of Oncology (2011)
Immunotherapy with VGX-3100 (HPV16 and HPV18 plasmids) + INO-9012 (DNA encoding IL-12) in human papillomavirus (HPV) associated head and neck squamous cell carcinoma (HNSCCa): interim safety and immunogenicity results
Authors: Charu Aggarwal, Roger Cohen, Matthew P Morrow, Joshua Bauml, Gregory Weinstein, Jean Boyer, Xuefei Shen, Jian Yan, Jessica Goldenberg, Drishty Nashit, Sandra Oyola, Jessica Lee, Laurent M Humeau, David B Weiner, Zane Yang, Mark L Bagarazzi, David Weiner
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Oropharyngeal HNSCCa is frequently associated with HPV infection. DNA-based Immunotherapy with plasmids encoding HPV16 and HPV18 E6/E7 antigens has been shown to generate robust immune responses in women with HPV-driven high-grade cervical dysplasia. We hypothesize that HPV-
The genetic kaleidoscope of vision
Authors: Douglas Wahlsten
Journal: Behavioral and Brain Sciences (1995)

Abstract Site-specific phenotypic effects of the 73 known alleles in the rhodopsin gene that cause retinal degeneration are difficult to interpret because most alleles are documented in only one case or one family, which means variation in effects could actually arise from interactions with other loci. However, sample sizes necessary to detect epistatic interaction may place an answer to this question beyond our grasp.
Abstract 3482: Prevalence and Progression of Subclinical Atherosclerosis in Younger Adults with Low 10-Year Risk but High Lifetime Risk for Cardiovascular Disease: Findings from the CARDIA and MESA Studies
Authors: Jarett D Berry, Kiang Liu, Aaron R Folsom, Joseph F Polak, Cora E Lewis, Steven Shea, Stephen Sidney, J. J Carr, Daniel H O’Leary, Cheeling Chan, Donald M Lloyd-Jones
Journal: Circulation (2007)

Objective : The Adult Treatment Panel (ATP) III recommends estimating 10-year risk for cardiovascular disease (CVD), but this strategy identifies few individuals age ≤ 50 years as high risk. Many individuals have a lifetime risk up to 70% despite a low 10-year risk (&lt;10%) for CVD. We hypothesized that individuals with low 10-year/high lifetime risk would have a greater burden of subclinical atherosclerosis compared to individuals with low 10-year/low lifetime risk. Methods : We included individuals age ≤ 50 from two multiethnic NHLBI-sponsored studies designed to assess the importance of risk factors in the development of CVD [2988 from Coronary Artery Risk Development in Young Adults (CARDIA) study;1076 individuals from the Multi-Ethnic Study of Atherosclerosis (MESA)]. The ATP III 10-year risk and lifetime risk for CVD were estimated for each participant, permitting stratification into three groups: low 10-year (&lt;10%)/low lifetime (&lt;39%) risk, low 10-year (&lt;10%)/high lifetime risk (≥ 39%), and high 10-year risk (≥ 10%). Diabetics were considered to have high 10-year (≥ 10%) risk in all analyses. Baseline levels (CAC, IMT) and change in levels of subclinical atherosclerosis (CAC progression) were compared across the 3 risk strata for both cohorts. Results : As expected, those with high 10-year risk (≥ 10%) had the greatest burden of subclinical atherosclerosis in both studies. Among individuals with low 10-year risk (91% of all participants) in CARDIA, individuals with a high lifetime risk had significantly greater carotid IMT, higher CAC prevalence, and greater incidence of CAC progression compared to individuals with low lifetime risk (see table ). A remarkably similar pattern of results was observed in MESA. Conclusions : Individuals with low 10-year but high lifetime risk for CVD have a greater subclinical disease burden and greater incidence of atherosclerotic progression compared to individuals with low 10-year but low lifetime risk. Baseline Carotid Intima-Media Thickness (IMT), Coronary Artery Calcium (CAC) Prevalence and Progression among CARDIA Participants
Can anti‐migratory drugs be screened in vitro? A review of 2D and 3D assays for the quantitative analysis of cell migration
Authors: Christine Decaestecker, Olivier Debeir, Philippe Van Ham, Robert Kiss
Journal: Medicinal Research Reviews (2006)

Abstract The aim of the present review is to detail and analyze the pros and cons of in vitro tests available to quantify the anti‐migratory effects of anti‐cancer drugs for their eventual use in combating the dispersal of tumor cells, a clinical need which currently remains unsatisfied. We therefore briefly sum up why anti‐migratory drugs constitute a promising approach in oncology while at the same time emphasizing that migrating cancer cells are resistant to apoptosis. To analyze the pros and cons of the various in vitro tests under review we also briefly sum up the molecular and cellular stages of cancer cell migration, an approach that enables us to argue both that no single in vitro test is sufficient to characterize the anti‐migratory potential of a drug and that standardization is needed for the efficient quantitative analysis of cell locomotion in a 3D environment. Before concluding our review we devote the final two parts (i) to the description of new prototypes which, in the near future, could enter the screening process with a view to identifying novel anti‐migratory compounds, and (ii) to the anti‐migratory compounds currently developed against cancer, with particular emphasis on how these compounds were selected before entering the clinical trial phase. © 2006 Wiley Periodicals, Inc.
A systematic review of interventions to improve recall of medical advice in healthcare consultations
Authors: Philip Wb Watson, Brian Mckinstry
Journal: Journal of the Royal Society of Medicine (2009)

Background In order for patients to adhere to healthcare advice, it is essential that they are able to recall this following a consultation. Although psychological research exists which highlights techniques and factors postulated to influence recall, only a limited body of work has been conducted to evaluate their effectiveness in a clinical context. Aim To carry out a systematic review of intervention trials designed to enhance recall of medical information. Methods We searched Medline (1950-April 2007); Embase (1980-April 2007); Cinahl (1982-April 2007); PsychINFO (1969-2007); and the Cochrane Library Collection. Secondary searches were made through reference to relevant journals and reference lists from relevant papers/review papers. Results From 69 papers provisionally identified, 34 papers met the inclusion criteria. Nine recall interventions had been evaluated (audio recordings, written materials, adjunct questions, prompt sheets, visual aids, cognitive strategies, rehearsal, communication styles and personalized teaching). Despite the experimental and theoretical evidence which could have informed cognitive interventions to enhance recall of healthcare advice, most studies primarily focused on the use of written and/or audio-recorded medical instructions. Although the majority of studies supported these approaches insofar as they enhanced recall, the findings were equivocal. Conclusion While written and tape-recorded instructions appear to improve recall in most situations, a dearth of interventions incorporating psychological theory was readily apparent. Further research is required in clinical settings to determine if cognitive interventions based on a more over-arching psychological model of recall are effective.
Influence of endogenous prostaglandins on mTAL injury.
Authors: P Silva, S Rosen, K Spokes, M Taylor, F H Epstein
Journal: Journal of the American Society of Nephrology (1990)

We altered renal prostaglandin production by isolated rat kidneys in several ways to see if this would influence the susceptibility of cells lining the medullary thick ascending limb to injury. Rats were fed a diet containing either safflower oil (high in linoleic acid) or fish oil (low in arachidonate precursors) as a source of fat. After 90 min of perfusion, the kidneys of rats fed safflower oil showed only 32.7 +/- 6.7% of medullary thick ascending limb cells near the inner medulla with severe damage, whereas the same zone in perfused kidneys of rats fed fish oil showed 96.6 +/- 1.3% severely damaged cells (P less than 0.01). The protection afforded by safflower oil was accompanied by a doubling of urinary excretion of PGE2 and 6-keto-PGF1 alpha, and was eliminated by indomethacin, which suppressed prostaglandin synthesis. Perfusion with bradykinin also greatly increased prostaglandin excretion and reduced severe medullary thick ascending limb damage in the deepest zone of the outer medulla from 51.3 +/- 6.6% in controls to 28.5 +/- 5.9% (P less than 0.02). The protection provided by bradykinin was also completely reversed by indomethacin. The results suggest that endogenous prostaglandins serve a protective function against hypoxic injury for cells of the medullary thick ascending limb.
Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival
Authors: Evgenia Gubanova, Brandee Brown, Sergei V. Ivanov, Thomas Helleday, Gordon B. Mills, Wendell G. Yarbrough, Natalia Issaeva
Journal: Clinical Cancer Research (2012)

Abstract Purpose: Human papillomavirus (HPV) is linked with a subset of head and neck squamous cell carcinomas (HNSCC). HPV-positive HNSCCs show a better prognosis than HPV-negative HNSCCs, which may be explained by sensitivity of the HPV-positive HNSCCs to ionizing radiation (IR). Although the molecular mechanism behind sensitivity to IR in HPV-positive HNSCCs is unresolved, DNA damage response (DDR) might be a significant determinant of IR sensitivity. An important player in the DDR, SMG-1 (suppressor with morphogenetic effect on genitalia), is a potential tumor suppressor and may therefore be deregulated in cancer. No studies have yet been conducted linking defects in SMG-1 expression with cancer. We investigated whether deregulation of SMG-1 could be responsible for defects in the DDR in oropharyngeal HNSCC. Experimental Design: Expression and promoter methylation status of SMG-1 were investigated in HNSCCs. To identify a functional link between HPV infection and SMG-1, we transfected the HPV-negative cells with an E6/E7 expression construct. SMG-1 short hairpin RNAs were expressed in HPV-negative cells to estimate survival upon IR. Results: Forced E6/E7 expression in HPV-negative cells resulted in SMG-1 promoter hypermethylation and decreased SMG-1 expression. Due to promoter hypermethylation, HPV-positive HNSCC cells and tumors express SMG-1 at lower levels than HPV-negative SCCs. Depletion of SMG-1 in HPV-negative HNSCC cells resulted in increased radiation sensitivity, whereas SMG-1 overexpression protected HPV-positive tumor cells from irradiation. Conclusions: Levels of SMG-1 expression negatively correlated with HPV status in cancer cell lines and tumors. Diminished SMG-1 expression may contribute to the enhanced response to therapy exhibited by HPV-positive HNSCCs. Clin Cancer Res; 18(5); 1257–67. ©2012 AACR.
Mass information campaign starts in UK as flu cases rise to 28
Authors: A. O'Dowd
Journal: BMJ (2009)

A mass public information campaign starts in the United Kingdom this week as leaflets on how to stop the spread of swine flu begin to arrive in every home.

The number of confirmed cases of the A/H1N1 virus in the UK had risen to 28 by Tuesday afternoon, as the BMJ went to press, and another 333 patients are being tested, the Health Protection Agency has said.

Twenty one countries around the world are now affected, the World Health Organization has said, with 1124 cases of confirmed swine flu and 26 deaths—25 in Mexico and one in the United States. Mexico still has the highest number of …
Role of duplex Doppler ultrasound in the assessment of patients with postprandial abdominal pain.
Authors: A F Muller
Journal: Gut (1992)

In 10 patients with postprandial abdominal pain thought likely to be the result of mesenteric ischaemia Doppler ultrasound examinations of the superior mesenteric and coeliac arteries were performed both after fasting and a standard meal of 800 kcal. Compared with control values Doppler waveform analysis suggested seven abnormal vessels. Two patients had abnormal fasting superior mesenteric artery waveforms manifested by very high peak systolic velocities together with spectral broadening (one also had evidence of coeliac artery stenosis), and one patient had normal velocities but an abnormal signal and evidence of proximal superior mesenteric stenosis was supported by colour Doppler imaging and confirmed by angiography. Postprandially, two patients showed very high peak systolic and end diastolic velocities in the superior mesenteric artery (one had had a normal fasting waveform signal) and one in the coeliac artery, suggestive of vascular stenosis, while one patient showed a fall in peak systolic velocity. The diagnosis of mesenteric ischaemia in two of these patients was supported by digital subtraction angiography and abdominal computed tomography. Doppler ultrasound may be a useful non-invasive investigation for patients with postprandial abdominal pain that helps to select patients for angiography. Patients with tight vascular stenosis may have abnormal fasting Doppler waveform patterns but in symptomatic patients further information may be obtained after the haemodynamic stress of feeding. Additional information to enhance the diagnostic sensitivity of the test may be obtained by colour Doppler imaging.
Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?
Authors: Robert H. Eckel, Steven E. Kahn, Ele Ferrannini, Allison B. Goldfine, David M. Nathan, Michael W. Schwartz, Robert J. Smith, Steven R. Smith
Journal: Diabetes Care (2011)

OBJECTIVE This report examines what is known about the relationship between obesity and type 2 diabetes and how future research in these areas might be directed to benefit prevention, interventions, and overall patient care. RESEARCH DESIGN AND METHODS An international working group of 32 experts in the pathophysiology, genetics, clinical trials, and clinical care of obesity and/or type 2 diabetes participated in a conference held on 6–7 January 2011 and cosponsored by The Endocrine Society, the American Diabetes Association, and the European Association for the Study of Diabetes. A writing group comprising eight participants subsequently prepared this summary and recommendations. Participants reviewed and discussed published literature and their own unpublished data. RESULTS The writing group unanimously supported the summary and recommendations as representing the working group's majority or unanimous opinions. CONCLUSIONS The major questions linking obesity to type 2 diabetes that need to be addressed by combined basic, clinical, and population-based scientific approaches include the following: 1) Why do not all patients with obesity develop type 2 diabetes? 2) Through what mechanisms do obesity and insulin resistance contribute to β-cell decompensation, and if/when obesity prevention ensues, how much reduction in type 2 diabetes incidence will follow? 3) How does the duration of type 2 diabetes relate to the benefits of weight reduction by lifestyle, weight-loss drugs, and/or bariatric surgery on β-cell function and glycemia? 4) What is necessary for regulatory approval of medications and possibly surgical approaches for preventing type 2 diabetes in patients with obesity? Improved understanding of how obesity relates to type 2 diabetes may help advance effective and cost-effective interventions for both conditions, including more tailored therapy. To expedite this process, we recommend further investigation into the pathogenesis of these coexistent conditions and innovative approaches to their pharmacological and surgical management.
The Case for a Medicare Drug Coverage Benefit: A Critical Review of the Empirical Evidence
Authors: Alyce S Adams, Stephen B Soumerai, Dennis Ross-Degnan
Journal: Annual Review of Public Health (2001)

▪ Abstract The lack of an outpatient prescription drug benefit under Medicare has become a conspicuous omission in the face of accelerated growth in prescription drug expenditures and increased availability of highly effective medications. This article provides a critical review of the empirical evidence on the effect of drug coverage on the use of prescription drugs, health care outcomes, and health care costs among Medicare beneficiaries. The existing literature provides considerable evidence that drug coverage is associated with greater use of all drugs and clinically essential medications and that not all forms of coverage provide the same protection. Longitudinal evidence from elderly and disabled persons in Medicaid indicates that restricting coverage has serious adverse health outcomes for sick and low-income beneficiaries that actually lead to increased health care costs.
Frequently asked questions about conscious will
Authors: Daniel M. Wegner
Journal: Behavioral and Brain Sciences (2004)

The commentators' responses to The Illusion of Conscious Will reveal a healthy range of opinions – pro, con, and occasionally stray. Common concerns and issues are summarized here in terms of 11 “frequently asked questions,” which often center on the theme of how the experience of conscious will supports the creation of the self as author of action.
Effectiveness of Continuous Glucose Monitoring in a Clinical Care Environment
Journal: Diabetes Care (2009)

OBJECTIVE To determine whether continuous glucose monitoring (CGM) is effective in the management of type 1 diabetes when implemented in a manner that more closely approximates clinical practice. RESEARCH DESIGN AND METHODS After completion of a 6-month randomized controlled trial (RCT) evaluating CGM in children, adolescents, and adults with type 1 diabetes, CGM was initiated in the trial's control group with less intensive training and follow-up than was included in the RCT. Subjects had an outpatient training session, two follow-up phone calls, and outpatient visits at 1, 4, 13, and 26 weeks. For subjects with baseline A1C ≥7.0%, the primary outcome was change in A1C at 6 months. RESULTS CGM use decreased from a median of 7.0 days/week in the first month in the ≥25-year-old group, 6.3 days/week in the 15–24 year olds, and 6.8 days/week in the 8–14 year olds to 6.5, 3.3, and 3.7 days/week in the 6th month, respectively (P &amp;lt; 0.001 for each age-group). Among subjects with baseline A1C ≥7.0%, CGM use was associated with A1C reduction after 6 months (P = 0.02 adjusted for age-group). Severe hypoglycemia decreased from 27.7 events per 100 person-years in the 6-month control phase of the RCT to 15.0 events per 100 person-years in the 6-month follow-up CGM phase (P = 0.08). CONCLUSIONS Frequent use of CGM in a clinical care setting may improve A1C and reduce episodes of hypoglycemia. However, sustained frequent use of CGM is less likely in children and adolescents than in adults.
Interleukin-22: Immunobiology and Pathology
Authors: Jarrod A. Dudakov, Alan M. Hanash, Marcel R.M. van den Brink
Journal: Annual Review of Immunology (2015)

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has evolved rapidly since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues, including the intestines, lung, liver, kidney, thymus, pancreas, and skin. IL-22 primarily targets nonhematopoietic epithelial and stromal cells, where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this review, we assess the current understanding of this cytokine, including its physiologic and pathologic effects on epithelial cell function.