tbuckley/cabot-search huggingface dataset:
TMIC-14DEPLETION OF GLIOMA INFILTRATING MYELOID DERIVED SUPPRESSOR CELLS PROMOTES ANTI-TUMOR T CELL RESPONSES
Authors: Neha Kamran, Youping Li, Mariela Moreno Ayala, Nicholas Raja, Felipe Nunez, Hikmat Assi, Pedro Lowenstein, Maria Castro
Journal: Neuro-Oncology (2015)

TMIC-14. DEPLETION OF GLIOMA INFILTRATING MYELOID DERIVED SUPPRESSOR CELLS PROMOTES ANTI-TUMOR T
Novel aurora kinases-targeted combination therapy for breast cancers
Authors: T. A. Samuel, W. Fiskus, Y. Wang, R. Rao, R. Kolhe, Y. Yang, R. Balusu, C. Buser, S. Peiper, K. N. Bhalla
Journal: Journal of Clinical Oncology (2008)

14569 Background: Aurora A and B are essential for normal mitosis. Aurora A (AA) is amplified and/or co-overexpressed with Aurora B (AB) in over 50% of breast cancers, including the basaloid variety, “Triple Negative” breast cancers. MK-0457 (M) is a pan- Aurora kinase inhibitor that inhibits tumor growth and induces apoptosis of cancer cells. Aurora kinases are chaperoned by hsp90, and their down regulation is known to sensitize transformed cells to paclitaxel. Vorinostat (V) is a pan-histone deacetylase inhibitor that induces growth arrest, differentiation and apoptosis of human breast cancer cells. By inhibiting HDAC6 and inducing acetylation and inhibition of hsp90, V depletes the levels of hsp90 chaperoned proteins. Methods: AA amplification in MB-231 (“Triple Negative”) and BT-474 (HER-2 amplified) cells was documented by FISH and array-CGH. The cells were treated with M (50 to 250 nM) and/or V (0.5 to 2.0 μM) for 24 to 48 hours. Cell cycle status, DNA endoreduplication (PI staining) and apoptosis (Annexin V/PI staining) were determined by flow cytometry. Intracellular protein levels of p-AA or p-AB, AA and AB, p-survivin, survivin, were determined by immunoblot analyses. Results: Treatment with M or V induces cell cycle G2/M phase arrest and apoptosis of the breast cancer cells. Treatment with M depleted phosphorylated (p)-AA, -survivin, and -Ser10 H3 levels. V induced hsp90 acetylation and depleted the levels of AA, AB and survivin. Both M and V induced formation of multi-polar mitotic spindles. Co-treatment with M and V mediated more depletion of AA and AB levels, as well as synergistically induced apoptosis of the breast cancer cells. In the orthotopic MB-231 xenograft breast cancer model, co-treatment with M and V caused significantly more tumor growth delay, lung metastases and survival than treatment with either agent alone. Utilizing an anti-acetylated-K69- hsp90 antibody, treatment with V was shown to induce in vivo hsp90 acetylation. This was associated with in vivo depletion of AA and AB levels. Co-treatment with M and V also caused greater in vivo attenuation of AA, AB and p-survivin. Conclusions: These studies support the rationale to evaluate the safety and efficacy of the combination of M and V, without or with paclitaxel, against breast cancers with AA amplification and/or overexpression. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Merck & Co. Novartis GlaxoSmithKline, Merck, Merck & Co., NewLink Genetics, Novartis Institute for Biomedical Research Inc., Pfizer
Comorbidity Significantly Impairs Quality Of Life In Patients After Allogeneic Hematopoietic Stem Cell Transplantation – Results From The Prospective German Multicenter Validation Trial
Authors: Daniel Wolff, Philipp Y. Herzberg, Steven Z. Pavletic, Pia Heussner, Friederike Mumm, Christina Balsiger, Inken Hilgendorf, Philipp Hemmati, Ernst Holler, Hildegard T Greinix, Sandra A. Mitchell
Journal: Blood (2013)
PWE-213 Inoperable pancreatic cancer: breaking down barriers to improve quality of life
Authors: K Angel, P Kaye
Journal: Gut (2015)

<h3>Introduction</h3> The average life expectancy for someone with locally advanced pancreatic cancer is 9–12 months. It is associated with weight loss and malabsorption secondary to pancreatic exocrine insufficiency. The management of this is often deficient and has been shown to have a severe impact on the quality of life (QOL). A recent research has shown patients prescribed Creon have a longer survival length than those who are treated with palliative chemotherapy. Also other research have highlighted the importance of nutritional intervention in influencing survival. The All Party Parliamentary Group on Pancreatic Cancer has recommended that all patients be reviewed by a Dietitian. The aim of this project is to improve QOL by ensuring all pancreatic patients have timely access to a Dietitian. <h3>Method</h3> Research papers focusing on QOL and pancreatic insufficiency, along with previous clinical knowledge, were used to develop a treatment pathway and a questionnaire. Trust figures were used to determine the number of patients with pancreatic cancer who need to be seen by a Dietitian. <h3>Results</h3> A treatment pathway for dietetic intervention was established. All patients with an inoperable cancer are offered dietetic support, all patients with an operable cancer are seen by the dietetic team at the Tertiary Centre. All confirmed inoperable pancreatic cancer patients discussed at the multidisciplinary meeting, are contacted by a Dietitian to be offered a clinic appointment. All Gastroenterologists and Specialist Nurses have been asked to provide patients with a leaflet titled Why Do I Need to See a Dietitian. All newly diagnosed patients are booked into clinic within two weeks, if appropriate. Patients who are unable to attend clinic are offered a home visit. A questionnaire was developed to use during the initial appointment to assess factors that research has shown to affect QOL. This incorporates both malabsorption symptoms and nutritional problems. Pancreatic enzyme replacement therapy is discussed in detail with supportive literature provided. Each patient is then reviewed within two weeks to review dosage and tolerance. Personalised dietary advice has been provided to each patient to help deal with highlighted issues. The treatment pathway also involves checking each inoperable patient for Type 3C Diabetes Mellitus and nutritional deficiencies. <h3>Conclusion</h3> All patients in East Sussex diagnosed with an inoperable pancreatic cancer are able to access a Dietitian within two weeks of diagnosis. This enables speedy management of nutritional problems and pancreatic exocrine insufficiency, which is improving quality of life and helping to optimise chances for increasing survival. <h3>Disclosure of interest</h3> None Declared.
Binding of membrane-anchored macrophage colony-stimulating factor (M- CSF) to its receptor mediates specific adhesion between stromal cells and M-CSF receptor-bearing hematopoietic cells
Authors: N Uemura, K Ozawa, K Takahashi, A Tojo, K Tani, K Harigaya, S Suzu, K Motoyoshi, H Matsuda, H Yagita
Journal: Blood (1993)
Napalm
Authors: Peter Reich, Victor W. Sidel
Journal: New England Journal of Medicine (1967)

NAPALM, an incendiary substance made by the gelation of gasoline, has assumed an important role in warfare since its invention by Fieser1 in 1942. Named for naphthenate and palmitate, two constituents of the gelling agent, napalm has unique physical properties that have led to the perfection of various incendiary weapons. Physicians, concerned with war as well as disease, should be familiar with napalm and with the medical consequences of its use.Chemical and Physical PropertiesThe preparation of napalm is a simple procedure, utilizing inexpensive, abundantly available materials.2 A powder, consisting of the aluminum soaps of coconut acids, . . .
Abstract 13410: Diagnosing Heparin Induced Thrombocytopenia Post Cardiac Surgery
Authors: Rizwan A Manji, Alex Villafranca, Hilary Grocott, Alan H Menkis, Eric Jacobsohn
Journal: Circulation (2013)

Thrombocytopenia (Tcp) is common post cardiac surgery (CS) and may be due to heparin induced thrombocytopenia (HIT). HIT has a high rate of thrombosis necessitating anticoagulation with a non-hepar...
Hepatic visualization after /sup 131/I in patients with thyroid carcinoma
Authors: M. Blum
Journal: New England Journal of Medicine (1977)

This comment on a previous paper agrees that /sup 131/I-labelled thyroid hormone, produced endogenously from whole-body scanning dosages, accumulates in the liver in a physiologic fashion. Experience from 150 whole-body scans is reported with diagnostic success for liver, rib, iliac crest and adjacent lymph-node carcinomas. A time lag of 12 to 24 hours was noted between thyroid and physiologic hepatic accumulation. (PCS)
Immunotherapy of Metastatic Cancer in Guinea Pigs: Failure of Intralesional BCG to Influence the Results of Radical Surgery
Authors: James T. Hunter, James T. Hunter, Takao Okuda, Herbert J. Rapp
Journal: JNCI Journal of the National Cancer Institute (1977)

Guinea pigs with growing intradermal fransplants of a syngeneic hepatoma treated by intralesional injection of living BCG at a time when lymph node metastases were detectable by palpation were not cured but survived longer than did the controis. Treatment of the animals by excision of the transplant and draining lymph nodes, instead of by BCG, resulted in a significant number of cures. The cure rate of animals receiving both treatments was not demonstrably greater than that obtained in animals receiving surgery alone.
Ongoing effects of burns
Authors: Karan Jolly, James Andrew Douglas, Nathan Hamnett, Ibrahim Natalwala, William J C van Niekerk
Journal: BMJ (2016)

A 29 year old man presented with isolated injury to both lower limbs after accidental spillage of caustic soda 20 hours earlier at the metal cleaning factory where he worked. Despite removing soaked protective clothing at the time of exposure, a lack of irrigation of the area resulted in progressive development of skin changes (figs 1 and 2⇓) and associated pain to the affected limbs. This prompted him to attend his local emergency department.



Fig 1  Patient’s right leg





Fig 2  Patient’s left leg



1.  What type of injury is this?

2.  What is the size and depth of the burn?

3.  What are the different types of burns?

4.  How would you manage this patient?

### 1. What type of injury is this?

#### Short answer

Bilateral lower limb alkali chemical burns caused by exposure to caustic soda. The injury is circumferential and of heterogeneous depth.

#### Discussion

This injury is consistent with chemical burns caused by caustic soda (sodium hydroxide), which can occur in industrial and domestic settings. Other chemicals that cause such burns include:

Although exposure mainly causes cutaneous and ocular burns, some chemicals can have systemic effects if absorbed or inhaled. Chemical burns account for about 13% of all burns related mortality and 3.3% of all burns in the United Kingdom.1

An important feature of chemical burns is the tendency for the burning process to persist despite macroscopic source removal and resuscitation. Chemicals continue to denature proteins and damage tissues for as long as traces of …
Phase I/II Study of Induction Chemotherapy of Carboplatin and Irinotecan Followed By Sequential Thoracic Radiotherapy (Trt) for Elderly Patients with Limited-Stage Small-Cell Lung Cancer (Ld-Sclc): Torg 0604
Authors: Y. Misumi, H. Okamoto, K. Naoki, Y. Hosomi, Y. Takagi, T. Kato, N. Masuda, A. Takakura, K. Minato, Y. Miura, T. Yokoyama, S. Takata, K. Kishi, M. Nishikawa, F. Oshita, N. Seki, I. Goto, K. Watanabe
Journal: Annals of Oncology (2014)
The HER-2/neu oncogene in breast cancer: so what is new?
Authors: M N Levine, I Andrulis
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.7.1034 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1351536 The HER-2/neu oncogene in breast cancer: so what is new? M N LevinexM N LevineSearch for articles by this author , I AndrulisxI AndrulisSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.7.1034 First Page PDF © 1992 by American Society of Clinical Oncology
Notice of duplicate publication
Authors: F W Fitch, B Klein
Journal: Thorax (2002)

The article "Otorhinolaryngologic Computer-Assisted Biopsies of the Iceman" by Andreas R. Gunkel et al1 published in the March 1997 issue of the ARCHIVES (1997;123:253-256) is virtually identical to another article by 3 of the same authors2 published in Acta Oto-Laryngologica (Oslo) in March 1997.
P0794 : Relationship between HCV genotype, liver co-morbidities and fibrosis in the French cohort ANRS CO22 HEPATHER
Authors: F. Carrat, G. Haour, H. Fontaine, C. Dorival, M. Simony, M. Bourlière, J. Capeau, P. Carrieri, D. Larrey, C. Larsen, P. Marcellin, J.-M. Pawlotsky, J.-C. Trinchet, F. Zoulim, P. Cacoub, V. De Ledinghen, J. Dubuisson, P. Mathurin, F. Negro, G.-P. Pageaux, Y. Yazdanpanah, L. Wittkop, Z. Jean-Pierre, S. Pol
Journal: Journal of Hepatology (2015)
This mismanagement of the NHS amounts to neglect
Authors: Peter Bailey
Journal: BMJ (2016)

The basic needs of a vulnerable workforce are not being met

Today I’ve been working as a sessional GP in a village practice near Cambridge, seeing the usual mixture of common colds, hot children, lumps needing urgent referral, heart attacks, depression, and the worried well. Around me, in leafy Cambridgeshire, GPs are worrying about the recruitment crisis in primary care, with as many as 40% of GPs due to retire in the next five years.

Junior doctors are going back to work after a 48 hour strike over the imposition of their new contract. Administrators are trying to fill rota gaps without spending any money, and patients are trying to negotiate the complex bureaucratic barriers we’ve put in their paths to …
The Problem and Promise of Prognosis Research
Authors: Matthew A. Rysavy, Jon E. Tyson
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
VEGF single nucleotide polymorphisms (SNPs) and correlation to sunitinib-induced hypertension (HTN) in metastatic renal cell carcinoma (mRCC) patients (pts)
Authors: J. J. Kim, S. A. Vaziri, P. Elson, B. I. Rini, M. K. Ganapathi, R. Ganapathi
Journal: Journal of Clinical Oncology (2009)

5005 Background: VEGF SNPs (-634 C/C and -1498 T/T) have been associated with protection from grade III/IV HTN in breast cancer pts receiving bevacizumab plus paclitaxel (J Clin Oncol. 26:4672–4678). The aim of this study was to retrospectively evaluate the association among VEGF SNPs and the development of HTN in mRCC pts receiving sunitinib. Methods: mRCC patients receiving sunitinib (50mg 4/2) with available blood pressure (BP) data and germline DNA were retrospectively identified. All BP measurements were recorded in clinic approximately every 4 weeks. Genomic DNA was isolated from peripheral blood lymphocytes. VEGF SNP's -634 C/G (5’UTR polymorphism, NCBI reference sequence #2010963), and -1498 C/T (promoter polymorphism NCBI reference sequence #833061) were amplified using primers designed to flanking sequences for the respective SNPs. Genotypes were assigned following sequence analysis. Data were analyzed using parametric and non-parametric methods. Results: Sixty-four patients were identified of which 63 had available SNP data; 78% were male; median age was 60 (range 35–80); 67% ECOG performance status of 0; 89% prior nephrectomy and 63% previously treated with cytokines (48%) and/or a TKI (24%). Median systolic and diastolic BPs at baseline were 139 mmHg (range, 93–190) and 80 mmHg (range, 47–103), respectively; 57% of patients were being treated with anti-hypertensive therapies at baseline. The distribution of pts for the VEGF-634 genotype was C/C (10%), C/G (33%) and G/G (57%). VEGF-634 C/C &lt; C/G &lt; G/G genotypes were associated with increasing frequency and duration of HTN (diastolic &gt; 90 mmHg and/or systolic &gt; 150 mmHg) during treatment with sunitinib (p = 0.03 and p = 0.007, respectively) and remained significant adjusting for baseline BP and use of anti-HTN meds (p = 0.05 and 0.02, respectively). Similar correlations were not found for VEGF-1498 genotypes. There was no association between VEGF SNPs and tumor volume reduction or PFS. Conclusions: VEGF SNP-634 G/G genotype is correlated with HTN during treatment with sunitinib in mRCC pts. [Table: see text]
Drug abuse and criminal behavior in delinquent boys committed to a training school
Authors: J F Simonds, J Kashani
Journal: American Journal of Psychiatry (1979)

To determine drug use or drug abuse status according to DSM-III criteria, the authors interviewed 109 delinquent boys who had been committed to a training school. They categorized each boy as an offender against a person or as an offender against property only. They found that person offenders were significantly older, came from larger communities, abused a greater number of drugs, had higher asocial index scores, and had lower full-scale IQ scores than property-only offenders. The IQ score and the number of drugs abused were the most important variables predicting whether a subject belonged to the person offender or property-only offender group.
Abstract 18891: Prospective Evaluation of Diagnostic Performance and Safety of Implementing a Biventricular Approach for Endomyocardial Biopsy in Patients With Suspected Myocarditis
Authors: Philipp Lurz, Felix Foehrenbach, Christian Luecke, Daniel Urban, Enno Boudriot, Holger Thiele, Steffen Desch, Karin Klingel, Reinhard Kandolf, Gerhard Schuler
Journal: Circulation (2014)

Background: Previous retrospective analyses have suggested that biventricular (BV) endomyocardial biopsy (EMB) is superior to right (RV) or left ventricular (LV) EMB only in diagnosing patients with suspected myocarditis. Aim: To prospectively assess the feasibility, safety and diagnostic yield of BV EMB in consecutive patients with suspected myocarditis. Methods: Five to six EMBs were taken from the RV and LV under fluoroscopic guidance. Biopsies were analyzed in a core lab by highly experienced investigators (KK, RK) Myocarditis/myocardial in[[Unable to Display Character: &amp;#64258;]]ammation was de[[Unable to Display Character: &amp;#64257;]]ned as the detection of ≥14 infiltrating leukocytes/mm2 (CD3 T-lymphocytes and/or CD68 macrophages) in addition to enhanced HLA class II expression in professional antigen-presenting immune cells. Results: 100 consecutive patients (mean age 44 ± 15 years) with clinically suspected myocarditis were included. RV EMB was attempted in 100 patients, in 3 the procedure was abandoned due to unsatisfying positioning on the guiding catheter, in 1/97 RV EMBs were inadequate with no myocardial tissue obtained. LV EMB was attempted in 97 patients, in 3, LV EMB was not performed due to presence of LV thrombi, in 1/97 patient LV EMBs were inadequate with no myocardial tissue obtained. Major complication rate for LV EMB was 0% and for RV EMB, 1% (pericardial tamponade requiring surgical revision). Results of adequate BV EMBs were analyzed in 92 patients. On BV EMB, myocarditis was diagnosed in 61/92 patients. When considering LV EMB only, the diagnosis would have been missed in 3/61, when considering RV EMB only in 7/61 patients. Conclusion: BV EMB is feasible and safe in the majority of patients with suspected myocarditis and yields in a superior diagnostic performance as compared to a single ventricle EMBs.
Epidemiology of nontuberculous mycobacteria isolations among central North Carolina residents, 2006–2010
Authors: Genee S. Smith, Andrew J. Ghio, Jason E. Stout, Kyle P. Messier, Edward E. Hudgens, Mark S. Murphy, Stacy L. Pfaller, Jean-Marie Maillard, Elizabeth D. Hilborn
Journal: Journal of Infection (2016)
Molecular basis of the chemoprotective effect of white button mushrooms against breast cancer
Authors: Sharon Kwok, Yate-Ching Yuan, Kimberly Karlsberg, David Smith, Sheryl Phung, Shiuan Chen
Journal: Cancer Research (2005)

1580  An abnormal expression of aromatase in breast tissue is considered to be a risk factor for breast cancer. Aromatase inhibitors have been shown to be effective drugs in treating hormone-dependent breast cancer and potentially useful in preventing this cancer in postmenopausal women. Based on our results, we hypothesize that postmenopausal women can benefit from a diet that includes white button mushrooms (species Agaricus bisporus), a common vegetable, since they contain phytochemicals that have been shown to be effective aromatase inhibitors. To better understand the cancer protective effects of mushrooms, our laboratory has investigated the in vivo action of mushroom extract. Three sets of animal experiments have been conducted and the results suggest that the oral intake of mushroom extracts might slow MCF-7aro-derived tumor growth in nude mice. MCF-7aro is an ER-positive/aromatase-positive breast cancer cell line and demonstrates increased cell proliferation in the presence of testosterone. While it is exciting to find that mushroom extract contains anti-aromatase chemicals, it is reasonable to think that mushroom chemicals also affect other cellular pathways. As the first step, we have performed gene expression microarray analysis on MCF-7aro tumors from the mushroom-fed animals and those from the control animals. It was our goal to identify additional gene targets whose expression could also be modulated by the mushroom diet. We have performed the analysis using Affymetrix Human Genome U133A among three biological replicates, i.e., RNAs were isolated tumors from three individual animals and analyzed separately. The intensities of the probe signals on GeneChips were statistically normalized following a background noise subtraction, and were analyzed using algorithms in R/Bioconductor. We compared more than 22,000 gene expressions using two-sample t-tests and applied the Benjamini-Yekutieli p-value correction to control the false discovery rate. Using a minimum fold change criteria of 1.2 and an adjusted p-value cutoff of 0.05, we identified 515 genes that were up-regulated, and 1805 genes that were down-regulated in tumors from mushroom-fed mice versus those from control mice. The results indicate that a higher percentage of signal transduction genes are up-regulated and a higher percentage of genes involved in DNA processing and transcription/translation are down-regulated in tumors from mushroom-fed mice versus those from control mice. A careful evaluation of the results from microarray analysis will yield novel insights into the mechanisms as well as important signal-transduction pathways regulated by the phytochemicals in white button mushrooms.