tbuckley/cabot-search huggingface dataset:
Experimental myocardial infarction. I. Production of left ventricular failure by gradual coronary occlusion in intact conscious dogs
Authors: W. B. Hood, J. Joison, R. Kumar, I. Katayama, R. S. Neiman, J. C. Norman
Journal: Cardiovascular Research (1970)

Journal Article Experimental myocardial infarction. I. Production of left ventricular failure by gradual coronary occlusion in intact conscious dogs Get access William B. Hood, Jr., William B. Hood, Jr. From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, and the Sears Surgical Laboratory, Harvard Surgical Service, Boston City Hospital, and the Departments of Medicine and Surgery, Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Julio Joison, Julio Joison From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, and the Sears Surgical Laboratory, Harvard Surgical Service, Boston City Hospital, and the Departments of Medicine and Surgery, Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Raj Kumar, Raj Kumar From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, and the Sears Surgical Laboratory, Harvard Surgical Service, Boston City Hospital, and the Departments of Medicine and Surgery, Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Isao Katayama, Isao Katayama From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, and the Sears Surgical Laboratory, Harvard Surgical Service, Boston City Hospital, and the Departments of Medicine and Surgery, Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard S. Neiman, Richard S. Neiman From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, and the Sears Surgical Laboratory, Harvard Surgical Service, Boston City Hospital, and the Departments of Medicine and Surgery, Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar John C. Norman John C. Norman From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, and the Sears Surgical Laboratory, Harvard Surgical Service, Boston City Hospital, and the Departments of Medicine and Surgery, Harvard Medical School, Boston, Massachusetts, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 4, Issue 1, January 1970, Pages 73–83, https://doi.org/10.1093/cvr/4.1.73 Published: 01 January 1970 Article history Accepted: 06 August 1969 Published: 01 January 1970
The role of gut-liver axis in the pathogenesis of liver cirrhosis and portal hypertension
Authors: Yeon Seok Seo, Vijay H. Shah
Journal: Clinical and Molecular Hepatology (2012)

Because of the anatomical position and its unique vascular system, the liver is susceptible to the exposure to the microbial products from the gut. Although large amount of microbes colonize in the gut, translocation of the microbes or microbial products into the liver and systemic circulation is prevented by gut epithelial barrier function and cleansing and detoxifying functions of the liver in healthy subjects. However, when the intestinal barrier function is disrupted, large amount of bacterial products can enter into the liver and systemic circulation and induce inflammation through their receptors. Nowadays, there have been various reports suggesting the role of gut flora and bacterial translocation in the pathogenesis of chronic liver disease and portal hypertension. This review summarizes the current knowledge about bacterial translocation and its contribution to the pathogenesis of chronic liver diseases and portal hypertension. Keywords: Leaky gut; Bacterial translocation; Lipopolysaccharide; Toll-like receptor; Kupffer cell
Long-Range and Targeted Ectopic Recombination between the Two Homeologous Chromosomes 11 and 12 in Oryza Species
Authors: J. Jacquemin, C. Chaparro, M. Laudie, A. Berger, F. Gavory, J. L. Goicoechea, R. A. Wing, R. Cooke
Journal: Molecular Biology and Evolution (2011)

Whole genome duplication (WGD) and subsequent evolution of gene pairs have been shown to have shaped the present day genomes of most, if not all, plants and to have played an essential role in the evolution of many eukaryotic genomes. Analysis of the rice (Oryza sativa ssp. japonica) genome sequence suggested an ancestral WGD ∼50–70 Ma common to all cereals and a segmental duplication between chromosomes 11 and 12 as recently as 5 Ma. More recent studies based on coding sequences have demonstrated that gene conversion is responsible for the high sequence conservation which suggested such a recent duplication. We previously showed that gene conversion has been a recurrent process throughout the Oryza genus and in closely related species and that orthologous duplicated regions are also highly conserved in other cereal genomes. We have extended these studies to compare megabase regions of genomic (coding and noncoding) sequences between two cultivated (O. sativa, Oryza glaberrima) and one wild (Oryza brachyantha) rice species using a novel approach of topological incongruency. The high levels of intraspecies conservation of both gene and nongene sequences, particularly in O. brachyantha, indicate long-range conversion events less than 4 Ma in all three species. These observations demonstrate megabase-scale conversion initiated within a highly rearranged region located at ∼2.1 Mb from the chromosome termini and emphasize the importance of gene conversion in cereal genome evolution.
Left atrial C wave and mitral leaflet size
Authors: J. B. LAKIER, R. H. KINSLEY, W. A. POCOCK, J. B. BARLOW
Journal: Cardiovascular Research (1972)

The left atrial c wave (LAC) results from billowing of the mitral leaflets into the left atrial cavity shortly after the onset of left ventricular contraction. After increasing the size of the anterior mitral leaflet in five baboons by the insertion of a fascia lata patch, the amplitude of LAC was increased and its peak delayed. Since the mitral component of the first heart sound (M1 is known to coincide with the peak of LAC, this study confirms that the size of the mitral leaflets is an important factor in determining not only the amplitude of LAC but also the timing of M1.
T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease
Authors: K Matsuoka
Journal: Gut (2004)

In a prospective study endoscopic ultrasound localisation of pancreatic endocrine tumours was attempted in 21 patients with clinically suspected islet cell tumours. Most patients were referred after the failure of conventional imaging methods. Endoscopic ultrasound correctly identified the site of 12 of 15 insulinomas, one glucagonoma, and a diffuse pancreatic abnormality in a patient with multiple endocrine adenopathy. There were two true negative examinations and one technical failure. The sensitivity of endoscopic ultrasound was much greater than that of computed tomography or conventional transabdominal ultrasonography.
Augmentation of activity of cis-diamminedichloroplatinum(II) and mitomycin C by interferon in human malignant mesothelioma xenografts in nude mice.
Authors: Sklarin Nt, Chahinian Ap, Feuer Ej, Lahman La, Szrajer L, Holland Jf
Journal: Cancer Research (1988)

Abstract  Two human mesothelioma xenograft lines, BG and ES, serially passaged in athymic mice, were studied to determine the efficacy of α-interferon in this type of tumor. Treatment began after progressive tumor growth was established. Recombinant human α-interferon-2a (Roferon-A) was given by s.c. injection, at a site distant from the tumor, at a dose of 2 × 105 IU 5 days per wk for 5 wk. Mild inhibitory activity was noted in both lines with interferon alone. cis-Diamminedichloroplatinum(II) (CDDP) (4 mg/kg) weekly × 5 was effective in line BG, while mitomycin C (1.5 mg/kg) weekly × 3 was effective in line ES. CDDP was not as effective in line ES. The moderate activity of CDDP in line BG and of mitomycin C in line ES was markedly increased by the addition of α-interferon. The combination of mitomycin C and α-interferon was as effective as mitomycin C and CDDP. No additional toxicity was noted by the addition of α-interferon. The combination of recombinant human α-interferon-2a and active chemotherapeutic agents is effective in mesothelioma xenografts.
Dissociative Disorders in Dutch Psychiatric Inpatients
Authors: M C Friedl, N Draijer
Journal: American Journal of Psychiatry (2000)

The goal of this study was to determine the frequency of dissociative disorders in Dutch psychiatric inpatients.During a period of 12 months, 122 consecutively admitted adult psychiatric patients were screened with the Dissociative Experiences Scale. Patients scoring 25 and higher and a random selection of patients scoring lower than 25 were blindly interviewed with the Structured Clinical Interview for DSM-IV Dissociative Disorders, Revised. Interviews were scored independently by a blind rater.Ten (8%) of the 122 patients were diagnosed as having a dissociative disorder; two (2%) were diagnosed as having a dissociative identity disorder. Two patients (2%) had factitious dissociative identity disorder.The rate of dissociative disorders in this group of Dutch patients is comparable to the rates reported in other European studies but lower than rates reported in North American studies.
Quality-of-Life Outcomes for Adjuvant Chemotherapy in Early-Stage Non–Small-Cell Lung Cancer: Results From a Randomized Trial, JBR.10
Authors: Andrea Bezjak, Christopher W. Lee, Keyue Ding, Michael Brundage, Timothy Winton, Barbara Graham, Marlo Whitehead, David H. Johnson, Robert B. Livingston, Lesley Seymour, Frances A. Shepherd
Journal: Journal of Clinical Oncology (2008)

Adjuvant chemotherapy for early stage non-small-cell lung cancer (NSCLC) is now the standard of care, but there is little information regarding its impact on quality of life (QOL). We report the QOL results of JBR.10, a North American, intergroup, randomized trial of adjuvant cisplatin and vinorelbine compared with observation in patients who have completely resected, stages IB to II NSCLC.QOL was assessed with the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and a trial-specific checklist at baseline and at weeks 5 and 9 for those who received chemotherapy and at follow-up months 3, 6, 9, 12, 18, 24, 30 and 36. A 10-point change in QOL scores from baseline was considered clinically significant.Four hundred eighty-two patients were randomly assigned on JBR.10. A total of 173 patients (82% of the expected) in the observation arm and 186 (85% of expected) in the chemotherapy arm completed baseline QOL assessments. The two groups were comparable, with low global QOL scores and significant symptom burden, especially pain and fatigue, after thoracotomy. Changes in QOL during chemotherapy were relatively modest; fatigue, nausea, and vomiting worsened, but there was a reduction in pain and no change in global QOL. Patients in the observation arm showed considerable improvements in QOL by 3 months. QOL, except for symptoms of sensory neuropathy and hearing loss, in those treated with chemotherapy returned to baseline by 9 months.The findings of this trial indicate that the negative effects of adjuvant chemotherapy on QOL appear to be temporary, and that improvements (with a return to baseline function) are likely in most patients.
Genetic Resistance in Japanese Wild Mice (Mus musculus molossinus) to an NB-Tropic Friend Murine Leukemia Virus2
Authors: Takeshi Odaka, Hidetoshi Ikeda, Kazuo Moriwaki, Akio Matsuzawa, Michiru Mizuno, Kyoji Kondo
Journal: JNCI Journal of the National Cancer Institute (1978)

Wild mice (Sk, Hz-Vl, Hz-IV Om, Mol.A, Fu, Te, and Sn) trapped in various areas of Japan were crossed with mice of inbred strains (C57BL/6, C57L, BALB/c, and C57BL/10), and their progeny were infected with NB-tropic Friend nurine leukemia virus. Ten days after infection, the spleens were weighed, examined for macroscopic focal lesions, and assayed for infectious virus by the XC test. Genetic analysis indicated that 4 of 8 mice tested had a dominant gene that suppresses the virus replication; the gene resembles the Fv-4' allele. No mice with the Fv-2' allele were found.
Long-Term Survival of Dialysis Patients in the United States With Prosthetic Heart Valves
Authors: Charles A. Herzog, Jennie Z. Ma, Allan J. Collins
Journal: Circulation (2002)

Background — Minimal data exist on the long-term survival of dialysis patients after cardiac valve surgery. Current practice guidelines of the American College of Cardiology/American Heart Association Task Force on the management of patients with valvular heart disease proscribe the use of bioprosthetic (tissue) valves in hemodialysis patients. Methods and Results — Dialysis patients hospitalized for heart valve replacement surgery from 1978 to 1998 were retrospectively identified from the US Renal Data System database. Long-term survival was estimated by the life-table method. The impact of demographic differences and comorbidity on outcome were examined in a Cox proportional hazards model. The in-hospital mortality of 5858 dialysis patients undergoing valve surgery was 20.7%. Aortic valve replacement was performed in 3415 patients (58%), mitral valve replacement in 1848 patients (32%), and combined aortic and mitral valve replacement in 562 patients (10%). Tissue valves were used in 881 patients. There was no significant difference in survival related to type of prosthetic valve. The 2-year survival rate was 39.7±3.5% with tissue valves versus 39.7±1.4% for nontissue valves. Compared with nontissue prosthetic valves, the use of tissue valves was not predictive of death (RR 0.98; 95% CI 0.90 to 1.07). Conclusions — There is no significant difference in survival of dialysis patients after cardiac valve replacement with tissue versus nontissue prosthetic valves. Current practice guidelines proscribing the use of bioprosthetic heart valves in hemodialysis patients should be rescinded.
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease
Authors: Iris T. Chan, Jeffery L. Kutok, Ifor R. Williams, Sarah Cohen, Lauren Kelly, Hirokazu Shigematsu, Leisa Johnson, Koichi Akashi, David A. Tuveson, Tyler Jacks, D. Gary Gilliland
Journal: Journal of Clinical Investigation (2004)

Oncogenic ras alleles are among the most common mutations found in patients with acute myeloid leukemia (AML). Previously, the role of oncogenic ras in cancer was assessed in model systems overexpressing oncogenic ras from heterologous promoters. However, there is increasing evidence that subtle differences in gene dosage and regulation of gene expression from endogenous promoters play critical roles in cancer pathogenesis. We characterized the role of oncogenic K-ras expressed from its endogenous promoter in the hematopoietic system using a conditional allele and IFN-inducible, Cre-mediated recombination. Mice developed a completely penetrant myeloproliferative syndrome characterized by leukocytosis with normal maturation of myeloid lineage cells; myeloid hyperplasia in bone marrow; and extramedullary hematopoiesis in the spleen and liver. Flow cytometry confirmed the myeloproliferative phenotype. Genotypic and Western blot analysis demonstrated Cre-mediated excision and expression, respectively, of the oncogenic K-ras allele. Bone marrow cells formed growth factor–independent colonies in methylcellulose cultures, but the myeloproliferative disease was not transplantable into secondary recipients. Thus, oncogenic K-ras induces a myeloproliferative disorder but not AML, indicating that additional mutations are required for AML development. This model system will be useful for assessing the contribution of cooperating mutations in AML and testing ras inhibitors in vivo.
The Diabetes Prevention Program and Its Global Implications
Authors: Mark E Molitch, Wilfred Fujimoto, Richard F Hamman, William C Knowler
Journal: Journal of the American Society of Nephrology (2003)

Type 2 diabetes affects over 150 million adults worldwide and this figure is expected to double over the next 25 yr. This increase will be accompanied by a marked increase in the number of patients with ESRD due to diabetes. We hypothesized that a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes We randomly assigned 3234 nondiabetic persons with elevated fasting and postload plasma glucose concentrations to placebo, metformin (850 mg twice daily), or a lifestyle-modification program with the goals of at least a 7% weight loss and at least 150 min of physical activity per week. The mean age of the participants was 51 yr, and the mean body mass index was 34.0 kg/m(2); 68% were women, and 45% were members of non-Caucasian racial/ethnic groups. The average follow-up was 2.8 yr. The incidence of diabetes was 11.0, 7.8, and 4.8 cases per 100 person-years in the placebo, metformin, and lifestyle groups, respectively. The lifestyle intervention reduced the incidence of diabetes by 58% (95% CI: 48 to 66%) and metformin by 31% (95% CI: 17 to 43%), compared with placebo; the lifestyle intervention was significantly more effective than metformin. In conclusion, lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk and the lifestyle intervention was more effective than metformin. Because the lifestyle changes worked equally in all racial/ethnic groups in the Diabetes Prevention Program, they should be applicable to high-risk populations worldwide and may be able to reduce the projected progressive rise in the incidence of diabetes and the expected increase in ESRD.
Cardiac and Extracardiac Expression of Csx/Nkx2.5 Homeodomain Protein
Authors: Hideko Kasahara, Sonia Bartunkova, Martina Schinke, Makoto Tanaka, Seigo Izumo
Journal: Circulation Research (1998)

Abstract — Csx/Nkx2.5 is an evolutionary conserved homeobox gene related to the Drosophila tinman gene, which is essential for the dorsal mesoderm formation. Expression of Csx/Nkx2.5 mRNA is the earliest marker for heart precursor cells in all vertebrates so far examined. Previous studies have demonstrated that Csx/Nkx2.5 mRNA is highly expressed in the heart and at lower levels in the spleen, tongue, stomach, and thyroid in the murine embryo. Since some developmental genes are regulated by posttranscriptional mechanisms, we analyzed the developmental pattern of Csx protein expression at the single-cell level using Csx-specific antibodies. Immunohistochemical analysis of murine embryos at 7.8 days post coitum revealed that Csx protein is strongly expressed in the nucleus of endodermal and mesodermal cells in the cardiogenic plate. Subsequently, in the heart, Csx protein was detected only in the nucleus of myocytes of the atrium and the ventricle through the adult stage. During the fetal period, Csx protein expression in the nucleus was also noted in the spleen, stomach, liver, tongue, and anterior larynx. Unexpectedly, confocal microscopy revealed that Csx immunoreactivity was detected only in the cytoplasm of a subset of cranial skeletal muscles. Csx protein was not detected in the thyroid glands. The expression of Csx protein in all organs was markedly downregulated after birth except in the heart. These results raise the possibility that Csx/Nkx2.5 may play a role in the early developmental process of multiple tissues in addition to its role in early heart development.
Regulation of Cardiomyocyte Apoptotic Signaling by Insulin-like Growth Factor I
Authors: Lei Wang, Weiqiong Ma, Rachelle Markovich, Jaw-Wen Chen, Ping H. Wang
Journal: Circulation Research (1998)

Abstract —Apoptosis is regulated by specific intracellular signaling pathways. The development of cardiomyopathy involves the apoptosis of cardiomyocytes; however, the details of their apoptotic signaling are not yet known. Insulin-like growth factor I (IGF I) is an important survival growth factor for myocardium and other tissues, but the effects of IGF I on apoptotic signaling remain largely unknown. To study apoptotic signaling pathways in cardiomyocytes and to understand IGF I actions on the apoptotic signaling of cardiac muscle cells, we have defined the effects of IGF I on Bcl-2, Bax, caspase 3, DNA fragmentation, and cell survival in primary cardiomyocytes. Compared with Bax levels, the levels of Bcl-2 were found to be quite low in these cells. Serum withdrawal and doxorubicin reduced cell viability, increased fragmentation of DNA, increased cellular contents of Bax, and activated caspase 3. IGF I enhanced cell viability, suppressed DNA fragmentation, attenuated Bax induction, and suppressed caspase 3 activation. The levels of Bcl-2–associated Bax were increased after serum withdrawal and incubation with doxorubicin and were reduced by IGF I. Thus, cardiomyocyte apoptosis induced by serum withdrawal and doxorubicin likely results, in part, from the induction of Bax and activation of caspase 3, but IGF I may inhibit cardiomyocyte apoptosis by attenuating Bax induction and caspase 3 activation. These findings provide new insight into the mechanisms of cardiomyocytes apoptosis and may help elucidate how IGF I modulates apoptotic signaling in cardiac muscle.
422 PROJECTING THE CLINICAL IMPACT OF THERAPEUTIC REGIMENS INCLUDING BOCEPREVIR IN PREVIOUSLY UNTREATED ADULT SUBJECTS WITH CHRONIC HEPATITIS C GENOTYPE 1
Authors: S. Ferrante, J. Chhatwal, E.J. Dasbach, A. El Khoury, V. Sniukiene, F.F. Poordad, J.-P. Bronowicki, C.A. Brass
Journal: Journal of Hepatology (2011)
Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis.
Authors: P W Cheng, T F Boat, K Cranfill, J R Yankaskas, R C Boucher
Journal: Journal of Clinical Investigation (1989)

Cystic fibrosis (CF) respiratory epithelia exhibit abnormal anion transport that may be linked to abnormal lung defense. In these studies, we investigated whether primary cultures of CF respiratory epithelial cells regulate abnormally the sulfate content of high molecular weight glycoconjugates (HMG) participating in airways' mucosal defense. HMG, including glycosaminoglycans and mucin-type glycoproteins released spontaneously into medium and HMG released from cell surfaces by trypsin, were metabolically labeled with 35SO4- and [6-3H]-glucosamine (GlcN) or 35SO4- and [3H]serine. All three classes of HMG from CF cells exhibited 35S/3H labeling ratios 1.5-4-fold greater than HMG from normal or disease control cells. Differences for labeling ratios of HMG from CF cells were shown to be the consequence of increased 35SO4- incorporation rather than decreased peptide synthesis and release or HMG glycosylation. The buoyant density of CF mucin-type HMG also was increased, consistent with increased sulfation. These observations suggest that oversulfation of a spectrum of HMG is a genetically determined characteristic of CF epithelial cells and may play an important pathophysiological role by altering the properties of mucous secretions and/or the interactions between selected bacteria and HMG at the airways' surface.