tbuckley/cabot-search huggingface dataset:
PMO-220 Patient anticipation of some pain goes along way when predicting overall satisfaction with a colonoscopy procedure: Abstract PMO-220 Table 1
Authors: F-U-R Ali
Journal: Gut (2012)

Introduction Providing a quality patient experience is a key facet of the Global Rating Score (GRS). Patient surveys are considered an integral means of assessing satisfaction. Meeting the patient's expectations is likely to influence their assessment of the procedure. Methods We examined the factors that might potentially influence patient satisfaction with their colonoscopic procedure using a pre test questionnaire [self reported apprehension, the reason for any concerns, expectations of pain (represented as a visual analogue scale of 0–10, 0=no pain and 10=maximum pain) and previous experience of colonoscopy]. Data collected during the test itself (patient self reported pain scores collected immediately post procedure and sedation doses used) were compared with a post test questionnaire of overall satisfaction and willingness to undergo the test again in the future if required. Results 448 patients participated (287 females and 201 males). Age range 18–88 years and mean age was 58 years. The mean anticipation of pain on the visual analogue scale was 2.61. The most common causes of anxiety were “fear of cancer?” (n=70) followed by “pain” (n=35), “tear/perforation” (n=14) and “previous adverse endoscopic experiences” (n=9). The mean actual patient reported pain scores were 3.14. 63 patients (43 females and 19 males) was very worried before test and their average anticipated pain score (AtPS) was 4.19 (total average 2.61) and the actual pain score (AcPS) 3.48 (average 3.14). 225 patients were worried before test and their AtPS 2.95 and AcPS 3.37. The patients who were not worried, their AtPS were 1.74 and AcPS 2.8. Patients (n=32) whose expected pre test pain scores were between 7 and 10 on visual analogue scale expressed higher levels of satisfaction with their procedures than those with lower anticipated pain scores (0–6) [93.7% vs 73.8%]. Patients who had a pre test apprehension score >7 were more agreeable to undergo the test again than those with score <6. Conclusion Patient satisfaction is strongly correlated with patient comfort. Patients' appreciating that colonoscopy is a potentially painful procedure report a higher level of satisfaction and acceptance of the sedation offered. The importance appropriate preparation of the patient should not be underestimated. View this table: Abstract PMO-220 Table 1 Competing interests None declared. Reference 1. Global Rating Scale.
Abstract P4-04-06: Histone H2A Inhibits Breast Cancer Stem Cell Growth
Authors: AM Tourville Poirier, CRCHUM Balicki D.
Journal: Cancer Research (2010)

Abstract Introduction: Recent studies have identified epigenetic abnormalities as the underlying cause of many breast cancers. In particular, the aberrant acetylation of core histones may be a pivotal source of dysregulated expression of both oncogenes and tumour suppressor genes. Histone deacetylase inhibitors are known to restore histone acetylation and to induce cellular differentiation and growth arrest in breast cancer cells and are the object of extensive research for novel anticancer treatments. We hypothesize that acetylated proteins, in particular histone H2A, could also serve as an alternative substrate for histone deacetylase, thereby promoting cellular histone acetylation and arrest of cancer cell growth. Indeed, our previous results indicate that exogenous calf thymus histone H2A penetrates cells and their nuclei, and induces differentiation and senescence in human breast cancer cells. In contrast, human recombinant histone H2A and H2AX, which lack post-translational modifications, fail to yield these results in spite of the fact that human and bovine histone H2A are virtually identical in their amino acid sequences. However, these recombinant molecules were obtained from bacteria, which lack the intracellular machinery that is necessary to generate post-translational modifications. Thus, post-translational histone modifications are pivotal to the inhibition of breast cancer cell proliferation. Objective: We have extended our study to establish if exogenous calf thymus histone H2A could also induce growth arrest of breast cancer stem cells, and subsequently to determine which portion (s) of the histone H2A molecule is responsible for this action, using overlapping synthetic peptides. Materials and Methods: Breast cancer stem cells were incubated with exogenous calf thymus histone H2A and seven synthetic peptides corresponding to overlapping portions of the entire protein and include all of its post-translational modifications. Cellular morphology was observed and viable cells were counted using trypan blue exclusion. Control experiments were performed with normal breast cells, cells from fibrocystic breast tissues, and breast cancer cells that were not significantly enriched in cancer stem cells. Results and Discussion: Histone H2A inhibits breast cancer stem cell growth and increases their adhesion. Stem cells have recently been identified in many malignant tumours, including breast cancer. Since cancer stem cells are thought to be an important source of therapeutic resistance, they provide a novel research focus for alternative treatment strategies. Our results are very encouraging and may lead to the development of new pharmacological molecules targeting epigenetic abnormalities in breast cancer stem cells. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P4-04-06.
Comparison of transcolonic NOTES and laparoscopic peritoneoscopy for the detection of peritoneal metastases
Authors: R. Voermans, D. Faigel, M. van Berge Henegouwen, B. Sheppard, P. Fockens
Journal: Endoscopy (2010)

See also: Commentaire de travail de R. P. Voermans et al., pp. 904Endoscopy 2010; 42(11): 995-995DOI: 10.1055/s-0032-1306709
Abstract 4936: MicroRNAs located on 13q and 20q are differentially expressed between normal mucosa, adenomas and carcinomas of the large intestine
Authors: Lisette M. Timmer, Anne S. Bolijn, Beatriz Carvalho, Chris J.J. Mulder, Edwin Cuppen, Gerrit A. Meijer, Begoña Diosdado
Journal: Cancer Research (2011)

Abstract Background: In colorectal cancer (CRC) miRNA expression profiling studies have reported differences in expression between colorectal carcinomas and controls, microsatellite stable, microsatellite instable and chromosomal instable tumors, and demonstrated prognostic value for some miRNAs. However, the role of miRNAs in CRC pathogenesis has been only partially investigated. CRC results from the gradual accumulation of multiple genetic and epigenetic changes in the colorectal epithelial cells. The majority of CRCs (85%) shows an accumulation of chromosomal abnormalities. In CRC, up to 15% of the annotated miRNAs are located at regions of chromosomal instability implicated in colorectal adenoma to carcinoma progression. Two of the most frequent chromosomal aberrations in CRC are gain of 13q (&amp;gt;50%) and gain of 20q (&amp;gt;65%). A total of 36 miRNAs are located on these chromosomal arms. However, the leading cause of the miRNA's aberrant expression and the pathways through which they contribute to CRC have not been elucidated. Aim: To investigate the expression of miRNAs located on 13q and 20q in normal colon mucosa, adenomas and CRC. Materials &amp; Methods: DNA and total RNA was isolated from 48 colorectal adenomas, 51 CRCs and 10 normal mucosa samples. Multiplex Ligation-dependent Probe Amplification (MLPA) was used to determine DNA copy number gain of 13q and/or 20q. Expression levels of 17 miRNAs located on 13q and 19 miRNAs on 20q (miRBase release 15) were measured by TaqMan miRNA assays. Results: 11 Of the miRNAs located on 13q and 8 of the miRNAs located on 20q were detected in colon tissue. 15 Of these miRNAs were significantly differentially expressed between colorectal tumors compared to controls and 13 were differentially expressed between carcinomas and adenomas (p&amp;lt;0.05). In addition, 11 miRNAs were significantly differentially expressed between tumors with or without a 13q and/or 20q gain (p&amp;lt;0.05). Conclusion: Gene dosage effects of miRNAs located on chromosomes 13q and 20q play an important role in CRC progression, and taking this into account is essential to achieve a comprehensive understanding of the pathogenesis of this malignancy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4936. doi:10.1158/1538-7445.AM2011-4936
THU0592 Longitudinal Measurement of Fatigue in Rheumatoid Arthritis: Which Factors Predict Fatigue?
Authors: S. Van Dartel, H. Repping, D. van Hoogmoed, H. Knoop, G. Bleijenberg, P. van Riel, J. Fransen
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> In cross-sectional studies it was found that psychosocial factors, pain and daily functioning, rather than inflammation, are associated with fatigue severity in rheumatoid arthritis (RA). However, it is unknown which factors predict the course of fatigue over a longer period. <h3>Objectives</h3> The objective of this longitudinal study was 1) to investigate the change of fatigue over time and 2) to identify which factors predict fatigue severity over time in RA patients. <h3>Methods</h3> A prospective cohort study of one year duration was performed with monthly assessments of fatigue in consecutive patients with established RA. Patients with at least 3 measurements of fatigue over 12 months were included in the analysis (n=212). Fatigue was assessed with the Checklist Individual Strength (CIS). Disease-specific measures and a comprehensive set of psychosocial factors were measured at baseline. Baseline differences between severely and non-severely fatigued patients over time (cut point of 35 in mean CIS-fatigue score) were analyzed with a chi-square test, unpaired t-test or a Mann-Whitney U test, as appropriate. Backward multivariable chunk-wise linear regression analysis with 9 blocks was performed to identify which factors are relevant for fatigue severity over time. The blocks were sets of patient characteristics, disease related variables, pain, disability, psychological health, personality, cognitions and coping, social support and social functioning, sleep quality. <h3>Results</h3> The mean (SD) baseline CIS fatigue score was 31.0 (12.5), with 40.1% having severe fatigue. Within patients, fatigue levels appeared to fluctuate around a stable level (p=0.20). The multivariate linear regression analysis showed that age, gender, pain, physical functioning, optimism, self-esteem, self-efficacy, coping strategies like worrying and magnification of fatigue, social functioning and sleep quality are significant independent predictors for CIS-fatigue over time, with 56% of variance explained. Descriptive statistics are shown in table 1. <h3>Conclusions</h3> In RA patients, fatigue levels are quite stable over time. Having 12 months of severe fatigue is predicted by higher levels of pain and disability, lower self-esteem, lower self-efficacy and less productive coping styles, less well social functioning and less quality of sleep. <h3>Disclosure of Interest</h3> None Declared
68Ga-Labeled Anti–Prostate-Specific Membrane Antigen Peptide as Marker for Androgen Deprivation Therapy Response in Prostate Cancer
Authors: Carl Diedrich Schlenkhoff, Florian Gaertner, Markus Essler, Stefan Hauser, Hojjat Ahmadzadehfar
Journal: Clinical Nuclear Medicine (2016)

Prostate cancer was diagnosed in a 71-year-old man with an elevated prostate-specific antigen. The CT of the abdomen showed multiple para-aortal lymph nodes, and thus, a 68Ga anti–prostate-specific membrane antigen (PSMA-11) PET/CT was initiated, which showed, aside from the prostate cancer and multiple iliacal and para-aortal lymph node metastases, an increased tracer uptake in a lymph node left cervical. According to this advanced disease, a palliative therapy with GnRH agonist was initiated. A second PSMA-11 PET/CT was performed 4 months later, which showed a very good response; thus, additional radiation of the pelvis and the draining lymphatic system was performed.
496 CHANGES IN CIRCULATING HCV-RNA CONCENTRATIONS IN PATIENTS WITH CHRONIC HEPATITIS C IN THE ABSENCE OF ANTIVIRAL THERAPY
Authors: P. Barreiro, P. Labarga, J.V. Fernandez-Montero, E. Poveda, C. de Mendoza, C. Sanchez, E. Vispo, V. Soriano
Journal: Journal of Hepatology (2013)
Olfactory Loss—On the Road to Potential Diagnosis Criteria of Alzheimer Disease
Authors: Jie Zhang
Journal: JAMA Neurology (2016)

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Abstract 2976: Array comparative genomic hybridization analysis reveals distinct genetic alterations in African Americans with colon cancer
Authors: Hassan Brim, Edward L. Lee, Duane T. Smoot, Hassan Ashktorab
Journal: Cancer Research (2010)

Abstract Purpose: Microsatellite Instability (MIN), CpG Island Methylation phenotype (CIMP) and Chromosomal Instability (CIN) are known processes through which colorectal cancer (CRC) can occur. In a given tumor, one or more of these events might be responsible for tumor development. We previously reported the results of our MSI and CIMP analysis of colorectal tumors in African Americans (AA), a group at high risk. Here, we report our array Comparative Genomic Hybridization (aCGH) analysis of 30 AA colorectal tumors and its implication for the understanding of CRC development in this population. Experimental design: We applied aCGH using a 105k chip to identify copy number aberrations in samples from 30 AA colon cancer patients. In addition, we did a population comparative analysis with aCGH data in Caucasians as well as with a widely publicized list of colon cancer candidate genes (CAN genes). Bioinformatics analysis was done to calculate the chromosomal imbalance using Agilent Genomic Workbench 5.0. Results: There was an average of 30 aberrations per patient with all samples displaying some level of chromosomal instability. Analysis of DNA copy number of frequently altered chromosomes revealed that deletions occurred primarily in chromosomes 4, 8 and 18. Chromosomal duplications occurred in more than 50% of cases on chromosomes 7, 8, 13, 20 and X. The CIN profile showed some differences when compared to alterations in Caucasians (22 cases). Conclusions: Prominent chromosome X amplification in male patients and chromosome 4, 8 and 18 deletions were the primary targets in AAs. Most CAN genes were altered at high frequencies in AAs with EXOC4, EPHB6, GNAS, MLL3 and TBX22 as the most frequently deleted genes and HAPLN1, ADAM29, SMAD2 and SMAD4 as the most frequently amplified genes. CIN seems to be more prominent in AAs and may play a distinctive role in CRC development in this population. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2976.
OC-126 Translocation of multidisciplinary standardised clinical pathways between hospitals and health systems is feasible and can produce immediate improvement in perioperative outcomes of surgical treatment of oesophageal cancer: Abstract OC-126 Table 1
Authors: S Preston, S R Markar, C Baker, Y Soon, S Singh, D Low
Journal: Gut (2012)

<h3>Introduction</h3> Standardised postoperative care pathways (SPCP) allow the introduction of a targeted goal-directed approach to recovery following major cancer surgery. A standardised oesophagectomy clinical pathway was established at Virginia Mason Medical Center (VMMC), Seattle, USA in 1991 and has undergone five revisions up to 2011. No information exists as to whether pathways can be successfully relocated between different cancer programs and health systems. In March 2011 a multidiscliplinary team from the Royal Surrey County Hospital (RSC) visited VMMC and instituted a similar pathway in April 2011. The aim of this study is to determine the effect of the translocation and implementation of an oesophagectomy care pathway on postoperative outcomes within a 1 year time period. <h3>Methods</h3> Four groups were included in this study: 74 patients operated on at VMMC (2009–2011). 12 RSC patients operated on before the introduction of SPCP. 12 RSC patients operated on after the introduction of SPCP but not included. 12 RSC patients managed according to the SPCP. Groups were compared with respect to patient demographics, peri- and post-operative outcomes. <h3>Results</h3> Presenting demographics were similar in all groups with respect to BMI, medical co-morbidities, ASA grade and clinical stage. Age was significantly reduced Group 4 compared to Group 2 (p&lt;0.05). Following initiating SPCP the use of feeding jejunostomies increased (67%–100%; p&lt;0.05) as did immediate extubation (67%–100%; p&lt;0.05). Further statistically significant improvements were noted in complications, length of ICU and hospital stay. Group 3 also showed a less significant improvement in length of ICU and hospital stay, and first day mobilisation. <h3>Conclusion</h3> The results of this study demonstrate the potential for accelerated improvement in short-term outcomes following oesophagectomy through the translocation and integration of standardised postoperative pathways. SPCP can also change hospital processes to improve outcomes in other patients. A multidisciplinary approach with involvement of the entire health care team in the design, implementation, evaluation and revision of these pathways is essential and will help ensure all team members are committed to achieving specific targeted pathway goals. <h3>Competing interests</h3> None declared.
Prognostic factors in resected Stage I and II non-small lung cancer (NSCLC)
Authors: Laura V. Mauro, Liliana Dallurzo, David Smith, Maria J. Veloso, José Lastiri, Bartolomé Vasallo, María G. Pallotta, Elisa D. Bal de Kier Joffé, Lydia Puricelli
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4540 

Although early-stage NSCLC patients have a relative favorable prognosis, the risk of bad outcome remains substantial. Identification of reliable prognostic markers for disease recurrence and death has meaningful clinical application. The aim of this work was to investigate the expression patterns of some molecules engaged in growth and differentiation and possibly involved in the progression of NSCLC in a cohort of stage I/II patients (n=59) who underwent a successful surgical resection. We analyzed by IHQ the expression of the transcription factor Retinoic Acid Receptor beta (RARβ) and the Cellular Retinol-Binding Protein 1 (CRBP-1) involved in retinoid-mediated signaling. Besides, we studied the expression of the transmembrane protein E-Cadherin and its counterpart β-Catenin, and p53. Prognostic evaluation was performed with the multivariate Cox proportional hazard model. We found that about 50% of NSCLC completely lost or had a poor expression of E-Cadherin and β-Catenin, being the staining for these antigens significantly correlated (Pearson p<0.01). About 45% cases were positive for RARβ staining at cytoplasmic level, while only 20% showed nuclear staining. CRBP-1 staining was observed in 55% of the lung tumors. Immunostaining for p53 at nuclear level was observed in 30% of tumors. Correlation analysis indicated a positive association between RARβ and E-Cadherin expression. No relationship was found between the number of cells expressing the studied molecules and clinical pathological features, including sex, T and N (stage), histopathology and adyuvant therapy. The only exception was that epidermoid tumors presented a higher number of tumors with mutated p53 than adenocarcinomas (59 vs 18%, p<0.01). Univariate analysis showed a significant association between positive expression of RARβ or the loss of membrane E-Cadherin with shorter overall survival (log-rank test, 4.9 p<0.05 and 5.1 p<0.05, respectively). However, the multivariate study indicated that only RARβ expression was not influenced by other clinical pathological parameters. In conclusion in this cohort of resected stage I and II NSCLC, only RARβ independently predicted cancer-specific survival.
ECHOCARDIOGRAPHY CORE LAB REPRODUCIBILITY OF CARDIAC SAFETY ASSESSMENTS IN CARDIO-ONCOLOGY
Authors: Michel Georges Khouri, Bonnie Ky, Gary Dunn, Theodore Plappert, Virginia Englefield, Eric Yow, Huiman X. Barnhart, Martin St. John Sutton, Pamela Douglas
Journal: Journal of the American College of Cardiology (2015)
Large nylon bag causing gastric outlet obstruction in a patient with schizophrenia
Authors: Hakan Akinci, Fatih Karaahmet, Mevlut Hamamci, Sahin Coban
Journal: Endoscopy (2014)

A 62-year-old man was admitted to our clinic complaining of nausea, vomiting, and abdominal pain for 5 days. He had a history of schizophrenia and had been on antipsychotic treatment for 10 years. His vital signs were within normal limits, but on physical examination, he was found to have a distended abdomen with no palpable mass. The results of laboratory tests were within normal limits, except for a slight leukocytosis of 12 × 109/L (normal 4 – 10 × 109/L). Because, from his clinical presentation and an abdominal radiograph, we suspected he had intestinal obstruction, he underwent an abdominal computed tomography (CT) scan before having an endoscopic examination. Contrast-enhanced images showed a hyperdense area with irregular margins in the region of duodenum ([Fig. 1]).