tbuckley/cabot-search huggingface dataset:
Quality reporting – finally achievable?
Authors: Lars Aabakken
Journal: Endoscopy (2014)

The endoscopy report represents a vital component of all endoscopy practice as the primary means of communicating findings, procedures, and recommendations. Although endoscopists typically do report their procedures, the content, format and structure of such reports vary widely. Originally, reports were created in free text, similar to other medical record entries. These were unstructured, highly variable, and constructed in a format that was solely at the discretion of the endoscopist. Unfortunately, all too often such reports were incomplete and otherwise suboptimal as clinical and legal documents [1] [2]. Moreover, the language of endoscopy has typically not been standardized and no proper definitions or usage have been agreed.
A Multicenter Trial of Oral Zidovudine in Children with Advanced Human Immunodeficiency Virus Disease
Authors: Ross E. McKinney, Mary A. Maha, Edward M. Connor, Judith Feinberg, Gwendolyn B. Scott, Michael Wulfsohn, Kenneth McIntosh, William Borkowsky, John F. Modlin, Peggy Weintrub, Karen O'Donnell, Richard D. Gelber, Gail Knowlton Rogers, Sandra Nusinoff Lehrman, Catherine M. Wilfert
Journal: New England Journal of Medicine (1991)

Zidovudine has been shown to be an effective antiretroviral treatment in adults with human immunodeficiency virus (HIV) infection. We examined the safety of zidovudine and the tolerance of and therapeutic response to the drug in 88 children with advanced HIV disease. During a 24-week outpatient trial, zidovudine (180 mg per square meter of body-surface area per dose) was given by mouth every six hours and serial measurements were made of clinical, immunologic, and virologic indexes. Children who completed 24 weeks of treatment were permitted to continue receiving zidovudine.
Tc-99m Sestamibi Scintigraphy in Multiple Myeloma
Authors: F Di Gennaro, L Catalano, L Pace, A de Renzo, A M Pinto, S del Vecchio, B Rotoli, M Salvatore
Journal: Clinical Nuclear Medicine (1999)

Tc-99m sestamibi imaging was performed in two patients with multiple myeloma. Focal areas of increased uptake in one patient and diffuse skeletal uptake in the second patient were found. Tc-99m sestamibi appears to identify bone marrow and osteolytic involvement in multiple myeloma.
Abstract 4994: Association of protein inhibitor of activated STAT protein 4 with the development of pancreatic ductal adenocarcinoma identified by chromosomal analysis from single nucleotide polymorphism arrays
Authors: Wenwen Chien, Norihiko Kawamata, Kazu Okemoto, Seishi Ogawa, H. Phillip Koeffler
Journal: Cancer Research (2010)

Abstract The purpose of this study is to identify novel genomic alterations in pancreatic ductal adenocarcinoma (PDAC) by single nucleotide polymorphism arrays (SNP-chip). Genomic DNA from 12 tissues and 15 cell lines of PDAC was examined using 250K SNP-chip. Regions with gains and losses of DNA copy number and loss of heterozygosity (LOH) were identified. Additional 10 normal and 6 tumor samples were used in quantitative real-time PCR to validate a subset of genes in the region with copy number alterations. Our results were compared with previously reported data. Frequent gains of chromosomes: 1q, 2, 3q, 5, 7, 8q, 11, 12p, 14, 17q and 20q (&amp;gt;50% of cases) and losses of 8p, 9p and 18q (&amp;gt;33% of cases) were detected. LOH regions were identified in chromosome arms: 6p, 6q, 8p, 9p, 9q, 13q, 17p, 18q, 19p, 19q and 21q (&amp;gt;25% of cases). On 19p LOH region, a common deletion occurred at 19p13 which included the gene known as protein inhibitor of activated STAT protein 4 (PIAS4). The deletion of the gene and expression levels of PIAS4 were correlated in the PDAC samples. The effects of exogenous over-expression of PIAS4 and short hairpin RNA (shRNA)-mediated knockdown of endogenous PIAS4 on cell proliferation and apoptosis were examined, as well as identification of cell signaling pathway linking PIAS4 and pancreatic tumorigenesis. Over-expression of PIAS4 decreased pancreatic cancer cell growth as well as decreased expression of genes involved in cell proliferation such as Bcl-2, Bcl-xL, cyclin D1 and XIAP. Activated PIAS4 decreased glycogen synthase kinase 3beta (GSK3beta) activity and inhibited transcriptional activity of nuclear factor kappa B (NFkB). Our data indicated that deletion of PIAS4 is associated with development of PDAC. Mechanistic studies showed that PIAS4 acted as a tumor suppressor gene and was a novel modulator of GSK3beta signaling in pancreatic tumorigenesis. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4994.
VOICE Campaign Launched for Cancer Education
Authors: D. A. Tisevich
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article VOICE Campaign Launched for Cancer Education Get access Dorothy A. Tisevich Dorothy A. Tisevich Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 16, 17 August 1994, Page 1194, https://doi.org/10.1093/jnci/86.16.1194 Published: 17 August 1994
Bill to curb privatisation in NHS clears first hurdle
Authors: C. Dyer
Journal: BMJ (2014)

A bill aimed at curbing the role of the private sector in the NHS in England has received strong backing in the UK parliament.

MPs voted by 241 to 18 to give a second reading to the National Health Service (Amended Duties and Powers) Bill, a private member’s bill that would reverse elements of the coalition government’s Health and Social Care Act 2012.

The bill, tabled by the Labour MP Clive Efford, would scrap rules made under the act, introduced by the Conservative and Liberal Democrat government, that provide for contracts for NHS …
Abstract 1699: Breast cancer protein markers in African Americans
Authors: Carolyn W. Broome, Desta Beyene, Ashwini K. Esnakula, Rachel Smith, Enass Abdel-Hameed, Tammey J. Naab
Journal: Cancer Research (2012)

Abstract The purpose of this study is to characterize protein markers in African American breast tumors that correspond to different tumor subtypes, recurrence, and survival. Tissue microarrays (TMA) have been used because they have the advantage of analyzing numerous samples on a single slide and can be used in clinical pathology laboratories. Protein markers that have been used are estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (Her2), cyclin A2, cytokeratin 5, vimentin, Bcl2, and Ki67. TMA have been prepared and stained for proteins that will distinguish 5 tumor subtypes: luminal A (ER+ and/or PR+ Her2-); luminal B (ER+ and/or PR+ Her2- Cyclin A2+ and/or Ki67+); luminal B Her2+ (ER+ and/or PR+ Her2+); Her2+ (ER- PR- Her2+), and triple negative (ER- PR- Her2-). These subtypes are known to be associated with different relapse-free survival and overall survival. Luminal B tumors have the same ER+PR+HER2- profile as luminal A tumors; however, luminal B tumors have a poor prognosis, whereas luminal A tumors have the best prognosis of all 5 subtypes. Luminal B tumors can be distinguished from luminal A tumors by staining for cell cycle proteins Cyclin A2 or Ki67, which promote cell proliferation. Cyclin A2 was more frequently expressed than Ki67 in tumors with poor prognosis such as luminal B (ER+PR+HER-) and ER-PR-HER2- (triple negative) tumors. Therefore, Cyclin A2+ may better serve to identify luminal B and triple negative tumors with a poor prognosis and thus aid physicians in treatment decisions. The RASSF1A protein has been reported to inhibit the transcription of Cyclin A2. Methylation of the RASSF1A promoter is expected to decrease RASSF1A transcription and thereby increase Cyclin A2 transcription and protein levels. Significantly increased levels of RASSF1A methylation have been observed in this laboratory with AA ER-PR-HER- breast cancer patients compared to mammoplasty samples. Thus, increased Cyclin A2 protein staining correlated with increased RASSF1A methylation. This is one molecular explanation for elevated cyclin A2 protein levels in triple negative tumors. Discovery of molecular markers and subtypes that are most prevalent in African Americans could lead to a better treatment, targets for therapy, and understanding of the factors contributing to higher mortality in this group compared to other groups. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1699. doi:1538-7445.AM2012-1699
First Amendment Rights of Patients and Physicians
Authors: M. V. Mangat, L. Burke-Galloway
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intérêt du nouveau couteau de dissection sous muqueuse «Dual-Knife» pour le traitement endoscopique du diverticule de Zenker
Authors: A Laquière, J Bouland, J Boitard, F Fumex, T Maniere, T Manos, JL Peroux, A Bremondy, X Moncoucy, E Debono, O Croizet, B Vedrenne, C Boustière
Journal: Endoscopy (2012)

Le Dual-knife (Olympus®) est un nouveau couteau fréquemment utilisé pour la dissection sous muqueuse du fait de sa sûreté et de sa précision. L'objet de cette étude était d'évaluer l'efficacité et la tolérance du traitement endoscopique du diverticule de Zenker avec le Dual-knife assisté d'un diverticuloscope (Cook®).
COMPARISON OF FEASIBILITY AND SAFETY IN TRANSFEMORAL VERSUS TRANSAORTIC TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Takahide Arai, Thierry Lefevre, Mauro Romano, Thomas Hovasse, Kentaro Hayashida, Yusuke Watanabe, Philippe Garot, Bernard Chevalier, Marie-Caude Morice
Journal: Journal of the American College of Cardiology (2015)
Abstract LB-49: Surviving by empowerment
Authors: Judy Togbo
Journal: Cancer Research (2012)

Abstract Men's Health Network (MHN) is a national non-profit organization whose mission is to reach men, boys, and their families where theylive, work, play, and pray with health prevention messages and tools, screening programs, educational materials, advocacy opportunities, and patient navigation. MHN was founded in 1992 by a group of men's activists, therapists, and writers interested in improving the health and well-being of men, boys and families. It is a nonprofit incorporated in the District of Columbia. MHN has also been designated as a tax exempt organization under Section 501(c)(3) of the U.S. Internal Revenue Service code. MHN has received the highest rating (4 stars) from Charity Navigator. Men's Health Network (MHN) is undertaking a series of free state symposia on the health of men and their families around the country. MHN is presenting these symposia as an effort to educate health professionals and the public-at-large about significant family health issues. The symposia create awareness of such issues with state policy leaders, elected officials, and healthcare leaders as they deal with the reality of rising health care costs. These state symposia also create opportunities for additional networking for community outreach organizations throughout the state, as well as encourage preventative health measures and physician and patient dialogue. Among those invited to participate are: local, regional, and state public health department officials, key legislators, advocacy groups, medical associations, patient advocacy organizations, churches/parishes, community health leaders, and healthcare providers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-49. doi:1538-7445.AM2012-LB-49
Sequencing of the ST2 Gene Reveals a Haplotype That Determines Serum Total ST2 Levels in Individuals of African Ancestry
Authors: Lili Huang, Li Gao, Camila Figueiredo, Nicholas M. Rafaels, Candelaria I. Vergara, Ingo Ruczinski, Terri H Beaty, Kathleen C. Barnes, Rasika A. Mathias
Journal: Journal of Allergy and Clinical Immunology (2013)
PTU-120 Effectiveness Of Nurse Led Hepatitis C Treatment; A Large District General Hospital Audit
Authors: N Elamin, S Frayne, J Wadsworth, Y Reddy
Journal: Gut (2014)

<h3>Introduction</h3> Hepatitis C is the third most common risk factor for liver diseases in the UK. Updated estimates suggest that around 216,000 individuals are chronically infected with hepatitis C. Treatment with combination of pegylated Interferon and ribavarin is well established. Specialist viral hepatitis nurses working collabaratively with clinicians play a major role in delivering excellent clinical outcomes. <h3>Methods</h3> Evaluate the safety and clinical effectiveness of chronic hepatitis C treatment that was led by the specialist viral hepatitis nurses under the supervision of gastroenterologists. Data was obtained from a prospectively maintained hepatitis C database over a 5-year period from September 2008 to date. A retrospective analysis of the database was carried out looking at the treatment outcomes. Patients with liver transplant and/or co-infection with hepatitis B or human immunodeficiency virus (HIV) were excluded. The dedicated viral hepatitis specialist nurses closely followed up all patients. <h3>Results</h3> A large database of 437 patients who underwent treatment was analysed. There were 128 (29.2%) females and 309 (70.7%) males ranging between 23–84yrs old (mean age of 42). Majority of patients were treated with combination therapy of pegylated interferon α2a and ribavarin whilst a small proportion (28) have received (triple therapy) protease inhibitors. The total number of patients who achieved sustained virologic response (SVR) at the end of treatment were 264 (60.41%). 196 (74.42%) of those were genotype 3a, 57 (21.60%) were genotype 1a/1b and 11 (4.17%) were genotype 2b/2a. 43 (9.84%) were considered non-responders. 49 (11.21%) patients were unable to complete treatment due to critical physical or mental illness with 12 of those (24.50%) have achieved SVR. Patients’ feedback for this nurse-led service has been very positive. <h3>Conclusion</h3> Specialist nurse-led and clinicians supported hepatitis C service has delivered a high quality of care. Our dedicated specialist nurses working closely with clinicians have achieved high successful treatment rates in such a large cohort of patients. <h3>Disclosure of Interest</h3> None Declared.
CLINICAL IMPORTANCE OF COMPLEX AORTIC PLAQUE IN THE CHA2DS2-VASC SCORING SYSTEM IN PATIENTS WITH NONVALVULAR ATRIAL FIBRILLATION
Authors: Pil-Sung Yang, Tae-Hoon Kim, Jae-Sun Uhm, Kim Jong-Youn, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Journal: Journal of the American College of Cardiology (2016)
A Comparison between the Clinical Effects of Pyribenzamine and Those of Benadryl
Authors: Mary H. Loveless, Halla Brown
Journal: New England Journal of Medicine (1947)

ALTHOUGH twenty articles on the clinical effects of Benadryl have appeared in the American literature since early in 1946, when the drug was introduced, only five are to be found on Pyribenzamine. Feinberg and Friedlaender1 , 2 are the only investigators who have made serious inquiry into the practical value of both drugs, and no statistics are available on the relative efficiency of these two agents in the same subject. Furthermore, their prophylactic and therapeutic possibilities in "constitutional" reactions to overdosage of allergenic extract have been examined in only 8 cases.3 The purpose of the present report is to add observations on . . .
SELF-REPORTED GENERAL HEALTH AND OUTCOMES IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE: EXPERIENCES FROM THE GLOBAL STABILITY TRIAL
Authors: Ralph Alan Huston Stewart, Emil Hagstrom, Claes Held, Paul Armstrong, Philip Aylward, Christopher Cannon, Wolfgang Koenig, Jose Lopez-Sendon, Emile Mohler, Nermin Hadziosmanovic, Susan Krug-Gourley, Saulat Siddique, Philippe Steg, Harvey White, Lars Wallentin
Journal: Journal of the American College of Cardiology (2016)
PAPEL DE LA ULTRASONOGRAFÍA ENDOSCÓPICA EN LA ESTADIFICACIÓN DEL CÁNCER GÁSTRICO. NUESTRA EXPERIENCIA
Authors: P De La Torre Rubio, JG Martínez Cara, V Martoz-Ruiz, M López De Hierro, J De Teresa Galván, E Redondo Cerezo
Journal: Endoscopy (2013)

Introducción: Pacientes con cáncer gástrico deben someterse a una evaluación preoperatoria para clasificar la enfermedad (estadificación TNM) y decidir el esquema de tratamiento más adecuado. Objetivos: La elección de la técnica diagnóstica depende de la situación clínica y la experiencia local, de ahí, el interés en evaluar la utilidad de las pruebas diagnósticas empleadas en nuestra unidad. Material y Métodos: Estudio retrospectivo, observacional, descriptivo, en el que del total de ecoendoscopias realizadas entre Octubre de 2009 y Enero de 2013, se seleccionaron aquellos pacientes cuya indicación fue estadificación de cáncer gástrico (un total de 66). Se analizaron los resultados TNM obtenidos mediante USE, TAC, PET y anatomía patológica. Resultados: Con ecoendoscopia el 80.7% de los pacientes se presentaron en un estadio localmente avanzado, siendo lo más frecuente un estadio T4 (T4a 50%). En un 3% de los casos el tumor primario resultó infranqueable, y en el 95.4% la enfermedad metastásica no pudo ser evaluada por esta técnica. Por TAC, en un 68.2% el tumor primario no pudo ser evaluado (TX), y en los que sí, el estadio más frecuente fue T4a. Identificó metástasis en un 18.2% y ausencia de las mismas en 72.7%. El PET mostró gran concordancia, identificando metástasis en un 18.2% de los casos. Se intervinieron un 62.1% de los pacientes, siendo el hallazgo histopatológico más frecuente un estadio T4, con un 58.5% de pacientes N0, y para la enfermedad metastásica, 63.4% (M0), y un 12.2% (M1). Conclusiones: En nuestra experiencia, el valor predictivo positivo (VPP) de la USE para diagnosticar tumores T3 – 4 (aquellos que van a precisar neoadyuvancia) es del 93%, y el valor predictivo negativo (VPN) del 75%. Para el TAC el VPP para la determinación de resecabilidad es del 80%. Existe gran concordancia entre ambas técnicas para la determinación del T (coeficiente Kappa 79%).
Brain Blood Flow SPECT
Authors: FREDERICK J. BONTE
Journal: Clinical Nuclear Medicine (1999)

SPECT evaluation of regional cerebral blood flow is commonly used to evaluate patients who are thought to have one of the dementias. The most common of these is Alzheimer's disease (AD), which is characterized by posterior superior parietal areas of regional cerebral blood flow reduction, which are often symmetrical and comprise the most reliable SPECT diagnostic sign of AD. There are other causes of such flow abnormalities, which can produce errors in diagnosis. To the list of possible causes of posterior flow abnormalities must be added the affective disorders, including unipolar and bipolar depression, which may cause posterior inferior regional cerebral blood flow deficits. Two cases, occurring in young persons, illustrate this finding.
CRISPR-Cas9 Can Inhibit HIV-1 Replication but NHEJ Repair Facilitates Virus Escape
Authors: Gang Wang, Na Zhao, Ben Berkhout, Atze T Das
Journal: Molecular Therapy (2016)

Several recent studies demonstrated that the clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonuclease Cas9 can be used for guide RNA (gRNA)-directed, sequence-specific cleavage of HIV proviral DNA in infected cells. We here demonstrate profound inhibition of HIV-1 replication by harnessing T cells with Cas9 and antiviral gRNAs. However, the virus rapidly and consistently escaped from this inhibition. Sequencing of the HIV-1 escape variants revealed nucleotide insertions, deletions, and substitutions around the Cas9/gRNA cleavage site that are typical for DNA repair by the nonhomologous end-joining pathway. We thus demonstrate the potency of CRISPR-Cas9 as an antiviral approach, but any therapeutic strategy should consider the viral escape implications. Several recent studies demonstrated that the clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonuclease Cas9 can be used for guide RNA (gRNA)-directed, sequence-specific cleavage of HIV proviral DNA in infected cells. We here demonstrate profound inhibition of HIV-1 replication by harnessing T cells with Cas9 and antiviral gRNAs. However, the virus rapidly and consistently escaped from this inhibition. Sequencing of the HIV-1 escape variants revealed nucleotide insertions, deletions, and substitutions around the Cas9/gRNA cleavage site that are typical for DNA repair by the nonhomologous end-joining pathway. We thus demonstrate the potency of CRISPR-Cas9 as an antiviral approach, but any therapeutic strategy should consider the viral escape implications.
Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia
Authors: Qifang Zhang, Dewan Md Sakib Hossain, Priyanka Duttagupta, Dayson Moreira, Xingli Zhao, Haejung Won, Ralf Buettner, Sergey Nechaev, Marcin Majka, Bin Zhang, Qi Cai, Piotr Swiderski, Ya-Huei Kuo, Stephen Forman, Guido Marcucci, Marcin Kortylewski
Journal: Blood (2016)
Commentary: Immunological Reflections on Asbestos
Authors: Robert Burrell
Journal: Environmental Health Perspectives (1974)

As a pulmonary immunologist interest in all forms of immune injury to the lung, I have had some experience with related minerals, such as silica and coal mine dust. When compared to the immunologic aspects of silicosis or coal workers' pneumonitis (CWP), the bulk of the immunologic evidence concerning asbestosis is scanty and unimpressive. To begin with, most of the experimental work is irrelevant because it dealt with doses that were much too high. Moreover, infected rats were often the experimental animals, there were no attempts to distinguish effects caused by asbestos from those caused by the almost universal opportunistic infections by mycoplasmas, and finally too much of the work used irrelevant experimental procedures like injecting the asbestos fibers into some organ or lumen. Aside from this we can ask a few questions, speculate a little, suggest a few avenues of approach, award some bouquets, and cast a few stones. The pleural plaques contain collagen and I would expect that there would be immunofluorescent localization of globulin at these sites, but Zaidi (1) and Turner-Warwick (2) in separte studies on limited material did not find such. Do these people produce antilung connective tissue antibodies seen in other chronic pulmonary disease? Turner-Warwick has found them, but was unimpressed with the frequency in the small population of cases she has studied. Similarly, since IgA is known to be greatly increased in miners with CWP, could one look for IgA levels in patients with asbestosis? Turner-