tbuckley/cabot-search huggingface dataset:
How Well Is the Affordable Care Act Doing?
Authors: Ezekiel J. Emanuel
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clonal Behavior of a Rat Liver Cell Line and Its Modification by Repeated Treatments With a Carcinogenic Polycyclic Hydrocarbon 2
Authors: J. R. Starkey, H. L. Hosick
Journal: JNCI Journal of the National Cancer Institute (1977)

A rat liver cell line, Lew A1, was isolated from W/LEW rats. It had the normal female karyotype In the lower passage numbers, but in the higher passages it was aneuploid. This line was passaged 65 times, produced rat serum albumin, and consisted of an apparently homogeneous population of typical epithelial cells. The cells also had high levels of the inducible aryl hydrocarbon hydroxylase enzyme complex. A series of experiments described here defined the normal clonal behavior of this line and its modification by repeated treatments with a carcinogenic polycyclic hydrocarbon, 7,12-dimethylbenz[a]an-thracene. The results were discussed with particular reference to metastasis, preneoplastic changes, and neoplastic progression.
Encorafenib (Lgx818), an Oral Braf Inhibitor, in Patients (Pts) with Braf V600E Metastatic Colorectal Cancer (Mcrc): Results of Dose Expansion in an Open-Label, Phase 1 Study
Authors: C.A. Gomez-Roca, J. Delord, C. Robert, M. Hidalgo, R. von Moos, A. Arance, E. Elez, D. Michel, A. Seroutou, T. Demuth, J. Tabernero
Journal: Annals of Oncology (2014)
Abstract 12346: Additional Ganglionated Plexi Ablation Prevents Immediate Atrial Fibrillation Recurrence After Left Atrial Catheter Ablation
Authors: Daisuke Ishigaki, Takanori Arimoto, Tadateru Iwayama, Naoaki Hashimoto, Joji Nitobe, Hiroshi Aoyama, Tetsu Watanabe, Isao Kubota
Journal: Circulation (2013)
Virus load and disease severity in acute bronchiolitis
Authors: Håvard Ove Skjerven, Spyridon Megremis, Kai-Håkon Carlsen, Petter Mowinckel, Nikos Papadopoulos, Karin C. Lødrup Carlsen
Journal: European Respiratory Journal (2014)

Background:

Acute viral bronchiolitis is the most common cause of hospitalization in infants worldwide. Respiratory syncytial virus (RSV) is detected in a majority of patients, followed by human rhinovirus (HRV) and human metapneumovirus (MPV). The possible association between viral load detected and disease severity is unclear.

Methods:

In a multicenter clinical trial of bronchiolitis treatment in two consecutive winter seasons, nasopharyngeal aspirate was sampled from 363 subjects (62% boys, mean age 4.2 months) and analyzed by real-time PCR detection of RSV, MPV and HRV.

Semi quantitative clusters (1-3, 1 highest) of virus load were constructed for each virus based on the PCR threshold cycles (0-20) by using K-means clustering.

Results:

Mean (95 % confidence interval) estimated LOS was 80.6 (73.8-87.3) hours for all 363 children with no significant differences i LOS by viruses detected; 78.9 (71.6-86.3) in children with RSV, 75.6 hours (71.6-86.3) for MPV and 82.6 hours (70.5-94.8) for HRV. Among children with RSV detected (81%), increasing viral load was associated with longer length of stay

![Figure][1] 



(estimated in robust linear regression analyses adjusted for age to 16.3 hours for a change from a lower to a higher cluster level, p=0.02). No associations were found between LOS and viral level cluster within HRV or MPV.

Conclusion:

In patients hospitalized with moderate to severe acute bronchiolitis, RSV load is positively associated with length of stay.

 [1]: pending:yes
Improved Outcome with ATRA-Arsenic Trioxide Compared to ATRA-Chemotherapy in Non-High Risk Acute Promyelocytic Leukemia – Updated Results of the Italian-German APL0406 Trial on the Extended Final Series
Authors: Uwe Platzbecker, Giuseppe Avvisati, Gerhard Ehninger, Laura Cicconi, Christian Thiede, Felicetto Ferrara, Sonia Maria Orlando, Marco Vignetti, Giorgina Specchia, Marco Sborgia, Eros Di Bona, Massimo Breccia, Elisa Cerqui, Konstanze Döhner, Walter Fiedler, Marie von Lilienfeld-Toal, Bernd Hertenstein, Helmut R. Salih, Mohammed Wattad, Michael Lübbert, Christian H. Brandts, Mathias Hänel, Norbert Schmitz, Hartmut Link, Mariadomenica Divona, Chiara Frairia, Enrico Maria Pogliani, Claudio Fozza, Alfonso Maria D'Arco, Nicola Di Renzo, Agostino Cortelezzi, Francesco Fabbiano, Paola Fazi, Johannes Kullmer, Walter E. Aulitzky, Stefan W. Krause, Hans Salwender, Kerstin Schäfer-Eckart, Markus P. Radsak, Arnold Ganser, Hartmut Döhner, Sergio Amadori, Franco Mandelli, Richard F. Schlenk, Francesco Lo-Coco
Journal: Blood (2014)
Temporal-Spatial Distribution of Leukemia and Lymphoma in Connecticut
Authors: Fred Ederer, Max H. Myers, Henry Eisenberg, Patricia C. Campbell
Journal: JNCI Journal of the National Cancer Institute (1965)

With a recently developed statistical technique based on combinatorial methods/ cases of leukemia and lymphoma diagnosed among Connecticut residents during 1945–59 were tested for the presence of 1- and 2-year clusters within towns. The method had previously been found very powerful in detecting the case-clustering of poliomyelitis and infectious hepatitis. The leukemia cases, both childhood and all ages, showed no tendency to occur in 1- or 2-year clusters. The lymphoma (all ages) cases tended to cluster. When cases of leukemia and lymphoma were combined as if they had a common etiology, a result consistent with a hypothesis of no clustering was obtained.
Low Dose Thymoglobulin Results In Improved Outcomes After Allogeneic Unrelated Hematopoietic Stem Cell Transplantation (HCT) For Patients With Acute Myeloid Leukemia/ Myelodysplastic Syndrome Conditioned With Intravenous Busulfan and Fludarabine
Authors: Yasser Khaled, Megan Smith, Tori Smith, Jason Balls, Abraham Matar, Deborah Lamontagne, Roy M. Ambinder, Ahmed Zakari, Melhem M. Solh
Journal: Blood (2013)
The European Respiratory Society evaluates its 2013–2018 strategic plan implementation
Authors: Giovanni Battista Migliori, Elisabeth Bel, Guy Joos, Mark Elliott, Gernot Rohde, Stephen T. Holgate, Christina Gratziou, Dan Smyth, Mina Gaga, Carlos Robalo Cordeiro, Otto C. Burghuber, Guy Brusselle, Fernando Martin-Burrieza, Werner Bill, Betty Sax, Jørgen Vestbo
Journal: European Respiratory Journal (2016)

In July 2013 the European Respiratory Society (ERS) developed its 2013–2018 strategic plan to serve its members better and achieve its mission objectives (table 1) [1]. The outcomes of the previous 2006–2007 Strategy Meeting [2] summarising the ERS pillars (figure 1) and the recently published ERS Presidential plans were used as background material [3–5]. Mid-term evaluation of the 2012–2018 European Respiratory Society strategy implementation <http://ow.ly/WKhxk>
&lt;italic&gt;N&lt;/italic&gt;,&lt;italic&gt;N&lt;/italic&gt;-Dimethylformamide-Induced Modulation of Organ- and Tumor-Associated Markers in Cultured Human Colon Carcinoma Cells&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: J C Hager, D V Gold, J A Barbosa, Z Fligiel, F Miller, D L Dexter
Journal: JNCI Journal of the National Cancer Institute (1980)

Cultured human colon carcinoma cells were induced by the polar solvent N,N-dimethylformamide (DMF) to express a more differentiated phenotype as indicated by three types of antigen markers. Carcinoembryonic antigen expression in all DMF-induced cell lines was enhanced. Exposure of cells to DMF resulted in a reduction in ability to bind antibody to tumor-derived colon mucoprotein antigen (CMA) with a concomitant gain in binding of antibody to normal CMA. DMF-induced differentiation was further indicated by modulation of blood group antigen expression. DMF treatment decreased the amount of expression of the H-gene determinant. When DMF-treated cells were cultured in the absence of DMF for 14 days, the levels of expression of the antigen markers reverted to those characteristic of their untreated counterparts.
Copy Number Variation in Donor KIR Genes and Motifs Titrates Natural Killer (NK) Cells' Functional Response to EBV Infections and Influences the Risk of Developing Post-Transplant Lymphoproliferative Disease (PTLD) after Allogeneic HCT
Authors: Rehan M. Faridi, Taylor Kemp, Poonam Dharmani, Victor Lewis, Noureddine Berka, Jan Storek, Faisal Khan
Journal: Journal of Allergy and Clinical Immunology (2016)
The GERMELATOX DeCOG-trial: Attitude of German melanoma patients towards toxicity during adjuvant interferon treatment—Differences between the patient's and the physician's perspective.
Authors: Katharina C. Kaehler, Matthias Augustin, Christine Blome, Andrea Forschner, Ralf Gutzmer, Claus Garbe, Christoffer Gebhardt, Lucie Heinzerling, Thomas Kornek, Elisabeth Livingstone, Carmen Loquai, Lara Valeska Maul, Berenice M Rudolph, Dirk Schadendorf, Barbara Stade, Patrick Terheyden, Tobias Wagner, Axel Hauschild
Journal: Journal of Clinical Oncology (2015)

e20099 Background: Although trials of adjuvant interferon alfa-2b (IFNa-2b) in high-risk melanoma patients suggest improvement in disease-free survival (DFS), metaanalyses showed only a marginal overall survival benefit. Widespread use of IFNa-2b has decreased for its significant toxicity. This study addressed for the first time the attitudes and choice-based preferences of German patients and physicians for adjuvant treatment with IFNa-2b. Methods: In this multicenter trial („GERMELATOX trial“) we assessed preferences and utilities for health outcomes associated with IFN among melanoma patients (T1a, AJCC stage I, no IFN), and dermatooncologists from 10 German melanoma units using the standard gamble technique. The trial described four typical IFNa-2b side effect scenarios and three post-treatment outcomes: no relapse or melanoma recurrence (with or without IFNa-2b) leading to cancer death. We also asked patients and physicians about the improvement in 5-year DFS they would require to tolerate defined IFN side-effects. Results: Data were obtained from 150 patients and 116 physicians (median age: 53yrs/34yrs, 48.3%/66.4% female). Utilities for melanoma relapse (+/- IFN) were significantly lower than utilities for all scenarios of IFN side effects. Patients indicated a median threshold of 50% for being relapse free at 5 years after adjuvant IFN with mild-to-moderate side effects. In comparison, the median threshold for physicians was 30% indicating a higher willingness to accept side effects.. In case of severe side effects, the required chance had to be 70% for patients and 50% for physicians. Conclusions: This study demonstrated a marked variation among patients with respect to preferences on adjuvant IFN-a-2b treatment and a significant difference between the patient´s and physician´s attitude related to side effects and outcome. This difference might be meaningful in decision making for adjuvant treatment options and should therefore also be investigated in further trials for new adjuvant treatment modalities.
In Vitro and In Vivo Evidence That Ex Vivo Cytokine Priming of Donor Marrow Cells May Ameliorate Posttransplant Thrombocytopenia
Authors: Mariusz Z. Ratajczak, Janina Ratajczak, Boguslaw Machalinski, Rosemarie Mick, Alan M. Gewirtz
Journal: Blood (1998)
Description of a Murine Model of Experimental Hepatic Metastases2
Authors: Martin H. Goldrosen, Norman Paolini, Edward D. Holyoke
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Description of a Murine Model of Experimental Hepatic Metastases Get access Martin H. Goldrosen, Martin H. Goldrosen Search for other works by this author on: Oxford Academic PubMed Google Scholar Norman Paolini, Norman Paolini Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward D. Holyoke Edward D. Holyoke Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 77, Issue 3, September 1986, Pages 823–828, https://doi.org/10.1093/jnci/77.3.823 Published: 01 September 1986 Article history Received: 28 January 1986 Accepted: 28 May 1986 Published: 01 September 1986
Immunosuppressive medication use and risk of herpes zoster (HZ) in patients with systemic lupus erythematosus (SLE): A nationwide case-control study
Authors: Stephen Chu-Sung Hu, Feng-Lin Yen, Tsu-Nai Wang, Yu-Chih Lin, Chi-Ling Lin, Gwo-Shing Chen
Journal: Journal of the American Academy of Dermatology (2016)
Era 3 for Medicine and Health Care
Authors: Donald M. Berwick
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical pharmacokinetics of intraarterial cisplatin in humans.
Authors: T N Campbell, S B Howell, C E Pfeifle, W E Wung, J Bookstein
Journal: Journal of Clinical Oncology (1983)

The pharmacokinetics of intraarterially administered cisplatin (DDP) were studied in three patients with large hepatic tumors, and one patient with a fibrous histiocytoma in the thigh, using an assay sensitive to only those forms of non-protein bound DDP capable of reacting with the nucleophilic ligand diethyldithiocarbamate. Each patient received continuous intravenous and intraarterial infusions at various dose rates, with and without concurrent infusion of the neutralizing agent sodium thiosulfate. Steady-state DDP concentrations were achieved within two hours, and the mean (+/- SEM) plasma clearance at infusion rates of 5-15 mg/m2 per hour was 345 +/- 45 mL/m2 per minute. Apparent plasma clearance did not vary significantly with route of infusion. Based on the plasma clearance, predicted values for the relative advantage of an intraarterial infusion (Rt) were less than two for hepatic infusion; observed values averaged 1.9 +/- 0.5 (+/- SEM). The infusion of thiosulfate did not significantly increase plasma clearance. The mean (+/- SEM) extraction ratio for hepatic infusions was 0.24 +/- 0.09, and for infusion of the peripheral soft tissue sarcoma it was 0.27 +/- 0.03. These data indicate that from the point of view of both the tumor and the systemic circulation there is only a limited pharmacologic advantage for intraarterial infusion of DDP into organs with plasma flows of greater than 350 mL/m2 per minute.
&lt;italic&gt;Brief Communication:&lt;/italic&gt; Failure to Detect Chromosome Damage In Vivo in Friend Virus-Infected Leukemic Mice
Authors: S K Majumdar, J D Bilenker
Journal: JNCI Journal of the National Cancer Institute (1975)

The cytogenetic activity of Friend virus (FV) was tested in vivo on spleen and bone marrow cells of FV-infected leukemic C3H/HeJ and STS mice. No specific chromosome rearrangements were detected in the infected animals. Some chromosome abnormalities were recorded in both normal and diseased animals; however, aberrations did not significantly increase in the leukemic groups.
The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway
Authors: Jianxiang Chen, Muthukumar Rajasekaran, Hongping Xia, Xiaoqian Zhang, Shik Nie Kong, Karthik Sekar, Veerabrahma Pratap Seshachalam, Amudha Deivasigamani, Brian Kim Poh Goh, London Lucien Ooi, Wanjin Hong, Kam M Hui
Journal: Gut (2016)

<h3>Objectives</h3> Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. Alterations in microtubule-associated proteins (MAPs) have been observed in HCC. However, the mechanisms underlying these alterations remain poorly understood. Our aim was to study the roles of the MAP protein regulator of cytokinesis 1 (PRC1) in hepatocarcinogenesis and early HCC recurrence. <h3>Design</h3> PRC1 expression in HCC samples was evaluated by microarray, immunoblotting and immunohistochemistry analysis. Molecular and cellular techniques including siRNA-mediated and lentiviral vector-mediated knockdown were used to elucidate the functions and mechanisms of PRC1. <h3>Results</h3> PRC1 expression was associated with early HCC recurrence and poor patient outcome. In HCC, PRC1 exerted an oncogenic effect by promoting cancer proliferation, stemness, metastasis and tumourigenesis. We further demonstrated that the expression and distribution of PRC1 is dynamically regulated by Wnt3a signalling. PRC1 knockdown impaired transcription factor (TCF) transcriptional activity, decreased Wnt target expression and reduced nuclear β-catenin levels. Mechanistically, PRC1 interacts with the β-catenin destruction complex, regulates Wnt3a-induced membrane sequestration of this destruction complex, inhibits adenomatous polyposis coli (APC) stability and promotes β-catenin release from the APC complex. In vivo, high PRC1 expression correlated with nuclear β-catenin and Wnt target expression. PRC1 acted as a master regulator of a set of 48 previously identified Wnt-regulated recurrence-associated genes (WRRAGs) in HCC. Thus, PRC1 controlled the expression and function of WRRAGs such as FANCI, SPC25, KIF11 and KIF23 via Wnt signalling. <h3>Conclusions</h3> We identified PRC1 as a novel Wnt target that functions in a positive feedback loop that reinforces Wnt signalling to promote early HCC recurrence.
Athletic Injuries
Authors: Floyd R. Eastwood
Journal: New England Journal of Medicine (1964)

ORGANIZED school and college athletic activities today can become a substitute for the adventurous challenge formerly inherent in frontier life. They may also replace the potentially hazardous experiences associated with street drag racing and unsupervised sandlot and playground games. All supervised sports, especially team activities, provide opportunities to cope with danger, enhance the value of work and teach self-sacrifice, courage and perseverance. Thus, sports are an important part in the education of a whole personality. They can cause serious injury, however.In 1932 injury surveys were made by me for all sports in college. Also, special injury surveys were made . . .
Suppressor Cells and Survival of Patients With Advanced Gastric Cancer&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: M Zembala, B Mytar, I Ruggiero, W Uracz, T Popiela, A Czupryna
Journal: JNCI Journal of the National Cancer Institute (1983)

The association of suppressor cells with survival of patients with gastric cancer was investigated. Phytohemagglutinin (PHA)-induced lymphocyte response and the presence of nonspecific suppressor cells were assessed in patients with different stages of gastric cancer. The presence of suppressor cells was determined by their ability to inhibit the PHA response of normal peripheral blood mononuclear leukocytes. Depression of the PHA response was related to the stage of disease and was also associated with the presence of suppressor cells. Of 245 patients tested, 76 (31 %) had suppressor cells. Adherent, nonspecific esterase-positive cells (presumably, monocytes) accounted for the suppression in most cancer patients. The occurrence of suppressor cells and the tumor load were related because the incidence of detectable suppressor cells decreased after surgery in patients with resectable tumor but increased in patients undergoing palliative surgery. In patients with advanced disease who had a generally poor prognosis, the ocurrence of suppressor cells was associated with a significantly increased survival. Hence the common view that a depressed lymphocyte response correlates with a poor clinical outcome may not be valid in all types of cancer.
Phase 2 studies of immunochemotherapy +/- bortezomib (VC) in newly diagnosed non-germinal center B-cell-like (GCB) DLBCL: rapid prospective identification of non-GCB patients (PTS)
Authors: Fritz Offner, B Ferhanoglu, JA Reeves, HS Eom, K Doner, J Raposo, IW Flinn, C Suh, NM Chowhan, S Prasad, SJ Kussick, G Mulligan, A Rizo, JP Leonard
Journal: Annals of Oncology (2011)
Rise in Mortality From Tumors of the Testis in Japan, 1947–702
Authors: John A. H. Lee, Masaharu Hitosugi, Gerald R. Petersen
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Rise in Mortality From Tumors of the Testis in Japan, 1947–70 Get access John A. H. Lee, M.D., John A. H. Lee, M.D. 3Professor, Department of Epidemiology and International Health, School of Public Health and Community Medicine, University of Washington, Seattle, Wash. 98195 Search for other works by this author on: Oxford Academic PubMed Google Scholar Masaharu Hitosugi, M.D., Masaharu Hitosugi, M.D. 4Assistant Professor, Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerald R. Petersen, M.A., Ph.C. Gerald R. Petersen, M.A., Ph.C. 3Professor, Department of Epidemiology and International Health, School of Public Health and Community Medicine, University of Washington, Seattle, Wash. 98195 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 5, November 1973, Pages 1485–1490, https://doi.org/10.1093/jnci/51.5.1485 Published: 01 November 1973 Article history Received: 10 May 1973 Accepted: 09 July 1973 Published: 01 November 1973