tbuckley/cabot-search huggingface dataset:
Lymphoproliferative responses to human papillomaviruses in patients with cutaneous warts
Authors: F.C. CHARLESON, M. NORVAL, E.C. BENTON, J.A.A. HUNTER
Journal: British Journal of Dermatology (1992)

In vitro lymphoproliferative responses of peripheral blood mononuclear cells (PBMC) from patients with cutaneous warts, caused by infection with human papillomavirus type 1 (HPV‐1) or type 2 (HPV‐2), were assayed during the course of treatment. Purified HPV‐1 and HPV‐2 were used as antigens, as well as herpes simplex virus (HSV) and concanavalin A (Con A). All patients had normal percentages of subsets within the PBMC population and normal lymphoproliferative responses to Con A, and those with a clinical history of HSV infections had positive lymphoproliferative responses to HSV. Responses to both HPV antigens were poor. Only 10 of 100 assays of PBMC from 26 patients showed a stimulation index greater than 2. Addition of interleukin 2 made little difference in most cases. No correlation of clinical status of warts, i.e. improving, unchanged or resolved, with lymphoproliferation was found. When the PBMC were depleted of plastic‐adherent cells and enriched for T cells, some samples which had not shown a lymphoproliferative response to HPV‐1 or HPV‐2 became positive: this response was abolished when the adherent cells were re‐added. Thus it is possible that the adherent cell population from a proportion of patients contains cells which suppress lymphoproliferation, or that an immunoregulatory network is present so that lymphoproliferation does not take place in vitro without prior activation and cloning of T cells.
Does influenza vaccination increase consultations, corticosteroid prescriptions, or exacerbations in subjects with asthma or chronic obstructive pulmonary disease?
Authors: L J Tata
Journal: Thorax (2003)

Concern over the safety of influenza vaccination in individuals with obstructive airways disease has contributed to suboptimal rates of vaccine uptake in this group. We investigated the safety of influenza vaccine in older people with asthma or chronic obstructive pulmonary disease (COPD) in a cohort from the UK General Practice Research Database (GPRD).A population based cohort study of 12,000 individuals with asthma or COPD from 432 general practices was conducted. Incidence rate ratios (IRR) were calculated for asthma or COPD diagnoses, prescriptions for oral corticosteroids, and acute exacerbations on the day of vaccination and on days 1-2 and 3-14 after vaccination compared with other time periods in the influenza season.The IRRs for asthma or COPD diagnoses and oral corticosteroid prescriptions were increased on the day of vaccination (for example, the IRR for oral corticosteroid prescriptions for subjects with asthma during the 1992-3 influenza season was 8.24 (95% confidence interval 5.54 to 12.26)). However, there was no consistent increase in the IRR of any of the outcomes on days 1-2 or 3-14 after vaccination, and most of these IRRs were close to 1. Rates of exacerbation were low and showed no consistent statistically significant increase during any risk periods.Older people with asthma or COPD commonly have diagnoses recorded or prescriptions for oral corticosteroids given on the day of influenza vaccination, but there is no increased risk of adverse acute outcomes in the first 2 weeks after vaccination. Our findings strongly suggest that influenza vaccination is safe in this population.
Pseudo-obstruction in children: transplant or wait?
Authors: J D. V. DE GOYET
Journal: Gut (1999)

See article on page 570 

With advances in immunosuppression intestinal transplantation has emerged as a viable option for patients with chronic intestinal failure and life threatening complications. With a one year graft survival rate of around 60% over the past few years, the current situation compares favourably with the pre-1990 results when 30% survival rates were achieved (data from the Intestinal Transplant Registry: www.lhsc.on.ca/itr). At the 7th Meeting of the European Intestinal Transplantation Study Group (Brussels, 1998), one year survival rates up to 80–90% were reported by some very experienced centres.

In children, chronic intestinal pseudo-obstruction is often a primary disorder, either congenital or acquired. Secondary pseudo-obstruction is related to various systemic diseases and is more common in older patients. According to the pathological findings, the primary disease is classified as neuropathic, myopathic, or idiopathic if no specific pattern is recognised. The disease always involves the small bowel and may occur in any other (or all) regions of the digestive tract. …
Lung volume reduction surgery
Authors: D. M. Geddes
Journal: Thorax (1999)

Background.Surgery to reduce lung volume has recently been reintroduced to alleviate dyspnea and improve exercise tolerance in selected patients with emphysema.A reliable means of identifying patients who are likely to benefit from this surgery is needed.Methods.We measured lung resistance during inspiration, static recoil pressure at total lung capacity, static lung compliance, expiratory flow rates, and lung volumes in 29 patients with chronic obstructive lung disease before lung-volume-reduction surgery.The changes in the forced expiratory volume in one second (FEV 1 ) six months after surgery were related to the preoperatively determined physiologic measures.A response to surgery was defined as an increase in the FEV 1 of at least 0.2 liter and of at least 12 percent above base-line values.Results.Of the 29 patients, 23 had some improvement in FEV 1 including 15 who met the criteria for a response to surgery.Among the variables considered, only preoperative lung resistance during inspiration predicted changes in expiratory flow rates after surgery.Inspiratory lung resistance correlated significantly and inversely with improvement in FEV 1 after surgery (r=-0.63,P<0.001).A preoperative criterion of an inspiratory resistance of 10 cm of water per liter per second had a sensitivity of 88 percent (14 of 16 patients) and a specificity of 92 percent (12 of 13 patients) in identifying patients who were likely to have a response to surgery.Conclusions.Preoperative lung resistance during inspiration appears to be a useful measure for selecting patients with emphysema for lung volumereduction surgery (N
The Relationship Between Brain Volume and Walking Outcomes in Older Adults With and Without Diabetic Peripheral Neuropathy
Authors: Brad Manor, Elizabeth Newton, Amir Abduljalil, Vera Novak
Journal: Diabetes Care (2012)

OBJECTIVE Diabetic peripheral neuropathy (DPN) alters walking. Yet, the compensatory role of central locomotor circuits remains unclear. We hypothesized that walking outcomes would be more closely related to regional gray matter volumes in older adults with DPN as compared with nonneuropathic diabetic patients and nondiabetic control subjects. RESEARCH DESIGN AND METHODS Clinically important outcomes of walking (i.e., speed, stride duration variability, and double support time) were measured in 29 patients with DPN (type 2 diabetes with foot-sole somatosensory impairment), 68 diabetic (DM) patients (type 2 diabetes with intact foot-sole sensation), and 89 control subjects. Global and regional gray matter volumes were calculated from 3 Tesla magnetic resonance imaging. RESULTS DPN subjects walked more slowly (P = 0.005) with greater stride duration variability (P &amp;lt; 0.001) and longer double support (P &amp;lt; 0.001) as compared with DM and control subjects. Diabetes was associated with less cerebellar gray matter volume (P &amp;lt; 0.001), but global gray matter volume was similar between groups. DPN subjects with lower gray matter volume globally (P &amp;lt; 0.004) and regionally (i.e., cerebellum, right-hemisphere dorsolateral prefrontal cortex, basal ganglia, P &amp;lt; 0.005) walked more slowly with greater stride duration variability and/or longer double support. Each relationship was stronger in DPN than DM subjects. In control subjects, brain volumes did not relate to walking patterns. CONCLUSIONS Strong relationships between brain volumes and walking outcomes were observed in the DPN group and to a lesser extent the DM group, but not in control subjects. Individuals with DPN may be more dependent upon supraspinal elements of the motor control system to regulate several walking outcomes linked to poor health in elderly adults.
Phase II Study of Palbociclib (PD-0332991) + Letrozole vs Letrozole Alone in First-Line ER + /HER2- Advanced Breast Cancer
Authors: R.S. Finn, J.P. Crown, I. Lang, K. Boer, I.M. Bondarenko, J. Ro, X. Huang, S.T. Kim, S. Randolph, D.J. Slamon
Journal: Annals of Oncology (2013)
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype
Authors: Joseph D. Growney, Hirokazu Shigematsu, Zhe Li, Benjamin H. Lee, Jennifer Adelsperger, Rebecca Rowan, David P. Curley, Jeffery L. Kutok, Koichi Akashi, Ifor R. Williams, Nancy A. Speck, D. Gary Gilliland
Journal: Blood (2005)
Tumor Necrosis Factor Receptor–Associated Factor (Traf)2 Represses the T Helper Cell Type 2 Response through Interaction with Nfat-Interacting Protein (Nip45)
Authors: Rebecca Lieberson, Kerri A. Mowen, Kathryn D. McBride, Veronica Leautaud, Xiankui Zhang, Woong-Kyung Suh, Lin Wu, Laurie H. Glimcher
Journal: The Journal of Experimental Medicine (2001)

Recently we have identified a novel protein NIP45 (nuclear factor of activated T cells [NFAT]-interacting protein) which substantially augments interleukin (IL)-4 gene transcription. The provision of NIP45 together with NFAT and the T helper cell type 2 (Th2)-specific transcription factor c-Maf to cells normally refractory to IL-4 production, such as B cells or Th1 clones, results in substantial IL-4 secretion to levels that approximate those produced by primary Th2 cells. In studies designed to further our understanding of NIP45 activity, we have uncovered a novel facet of IL-4 gene regulation. We present evidence that members of the tumor necrosis factor receptor–associated factor (TRAF) family of proteins, generally known to function as adapter proteins that transduce signals from the tumor necrosis factor receptor superfamily, contribute to the repression of IL-4 gene transcription and that this effect is mediated through their interaction with NIP45.
The pulmonary physician in critical care * 13: The pulmonary circulation and right ventricular failure in the ITU
Authors: K McNeil
Journal: Thorax (2003)

Abstract The management of severe pulmonary hypertension associated with right ventricular failure is reviewed and its relevance to adults with acute respiratory distress syndrome (ARDS) is discussed. critical careright ventricular failurepulmonary hypertensionpulmonary embolismacute respiratory distress syndrome
Randomised controlled trial of sequential intravenous and oral azithromycin compared with intravenous ceftriaxone followed by cefixime both in combination with clarithromycin in hospitalized patients with community-acquired pneumonia
Authors: Arash Etemadi, Abdolreza Ardeshirzadeh, Mohammad Maaleki, Abbas Chenaneh, Siamak Ahmadi
Journal: European Respiratory Journal (2011)

The objective of the study was to compare the efficacy, safety, and tolerability of Azithromycin (500 mg) intravenously (i.v.) once daily followed by 250 mg orally twice daily for 14 days with Ceftriaxone (2 g) by i.v. infusion twice daily followed by Cefixime (400 mg) twice daily, both in combination with oral clarithromycin (500 mg) twice daily for the same duration in 63 adult patients initialy hospitalized with community-acquired pneumonia. All patients assessed both clinically and bacteriologically one month after the end of treatment. The results showed statistically significant higher clinical (93.4% vs. 85.4%) and bacteriological success rates (93.7% vs. 81.7%) for patients treated with Azithromycin, irrespective of the severity of the pneumonia. The time to resolution of fever was also faster (median time: 2 vs. 3 days) and hospitalization period was approximately 1 day less for patients who received Azithromycin. The treatment was converted to oral therapy immediately after the initial mandatory 3-day period of i.v.administration for a larger proportion of patients in the Azithromycin group than patients in the control group (50.2% vs. 17.8%). There were fewer deaths (3.0% vs. 5.3%) and fewer serious adverse events (12.6% vs. 16.5%) in the Azithromycin group than in the control group. The rates of drug-related adverse events were comparable in both groups. Thus, monotherapy with Azithromycin is superior to combination regimen of ceftriaxone plus clarithromycin, in the treatment of community-acquired pneumonia.
Demonstration of a specific neutrophil receptor for a cell-derived chemotactic factor.
Authors: I Spilberg, J Mehta
Journal: Journal of Clinical Investigation (1979)

The crystal-induced chemotactic factor, a cell-derived chemoattractant for neutrophils, binds specifically to a site on human neutrophils but not to erythrocytes or lymphocytes, suggesting a relationship between the presence of specific binding sites on the neutrophils and the ability to be chemotactically activated. The Scatchard analysis revealed an equilibrium dissociation constant at 37 degrees C of 0.446 micrometer and the presence of approximately equal to 6.44 x 10(5) binding sites for 125I-crystal-induced chemotactic factor per cell. Binding was not displaced by the synthetic chemotactic factors F-Met-Leu-Phe and Gly-His-Gly or by complement-activated plasma providing evidence of the specificity of the receptor.
Indium-111–Labeled Trastuzumab Scintigraphy in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer
Authors: Patrick J. Perik, Marjolijn N. Lub-De Hooge, Jourik A. Gietema, Winette T.A. van der Graaf, M. Alexander de Korte, Sharon Jonkman, Jos G.W. Kosterink, Dirk J. van Veldhuisen, Dirk T. Sleijfer, Pieter L. Jager, Elisabeth G.E. de Vries
Journal: Journal of Clinical Oncology (2006)

The cardiac and antineoplastic effects of trastuzumab may be related to specific uptake of trastuzumab in myocardium and tumor tissue, respectively. We evaluated whether indium-111 (111In)-labeled trastuzumab scintigraphy can predict cardiotoxicity and identify tumor lesions. In addition, we evaluated whether plasma markers for cardiac dysfunction can be used to predict cardiotoxicity.Patients with human epidermal growth factor receptor 2 (HER2) -positive metastatic breast cancer underwent gamma camera imaging from 15 minutes to 7 days after injection of 150 MBq 111In-diethylenetriamine penta-acetic acid anhydride (DTPA) -trastuzumab, after loading-dose trastuzumab, and after once-a-week trastuzumab doses for 11 weeks, and concomitant paclitaxel once every 3 weeks. Cardiac assessments were performed before treatment, and after four and six cycles. Plasma N-terminal probrain natriuretic peptide (NT-proBNP) and serum troponin I were measured with immunoassay.Fifteen of the 17 patients were available for cardiac and tumor uptake analysis. On the first scan, myocardial 111In-DTPA-trastuzumab uptake was observed in one patient with pre-existing cardiac arrhythmias, who did not develop heart failure during treatment. Severe cardiotoxicity occurred in three patients, without initial myocardial uptake, whereas one showed weak myocardial uptake after four cycles. The detection rate of single tumor lesions was 45%. New tumor lesions were discovered in 13 of 15 patients. Pretreatment plasma NT-proBNP levels were higher in patients with than without heart failure (mean, 534 [standard deviation, 236] v 105 [standard deviation, 79] ng/L; P = .009).Radiolabeled trastuzumab scintigraphy was not valuable in predicting trastuzumab-related cardiotoxicity in metastatic breast cancer patients, but can identify HER2-positive tumors. Measurement of plasma NT-proBNP is promising regarding prediction of trastuzumab-related cardiotoxicity.
Abdominal symptoms and gallstone disease: An epidemiological investigation
Authors: Torben Jørgensen
Journal: Hepatology (1989)

To date, it has never been established which symptoms are specifically caused by stones in the gallbladder. To examine this issue, the relationship between occurrence of gallstone disease diagnosed by ultrasonography and complaints about abdominal pain and discomfort was assessed in a random sample comprising 4,581 males and females, of whom 3,608 (79%) took part in the investigation. As regards the presence of gallstones, the predictive values of various complaints about pain and discomfort were very low, ranging from zero to 25.0%, whereas for the absence of gallstones the predictive value of no complaints about pain or discomfort was very high, ranging from 93.2 to 94.2%. In subjects with gallstones, the prevalence of upper right quadrantic pain during the last 12 months was equal to that in subjects with a normal gallbladder, whereas in chole-cystectomized subjects the prevalence of pain was significantly higher. Pain was not associated with size, number or motility of the stones. It is concluded that in a random population it is difficult to define the symptoms specific for gallstones and thereby to distinguish between symptomatic and asymptomatic gallstones.
Circumscribed palmar hypokeratosis: partial remission by photodynamic therapy
Authors: S. Benoit, C.S. Seitz, H. Hamm, C.S. Vetter-Kauczok, E.-B. Bröcker
Journal: British Journal of Dermatology (2007)

Journal Article Circumscribed palmar hypokeratosis: partial remission by photodynamic therapy Get access S. Benoit, S. Benoit Department of Dermatology, University of Würzburg, Josef‐Schneider‐Str. 2, D‐97080 Würzburg, Germany E‐mail: benoit_s@klinik.uni‐wuerzburg.de Search for other works by this author on: Oxford Academic Google Scholar C.S. Seitz, C.S. Seitz Department of Dermatology, University of Würzburg, Josef‐Schneider‐Str. 2, D‐97080 Würzburg, Germany E‐mail: benoit_s@klinik.uni‐wuerzburg.de Search for other works by this author on: Oxford Academic Google Scholar H. Hamm, H. Hamm Department of Dermatology, University of Würzburg, Josef‐Schneider‐Str. 2, D‐97080 Würzburg, Germany E‐mail: benoit_s@klinik.uni‐wuerzburg.de Search for other works by this author on: Oxford Academic Google Scholar C.S. Vetter‐Kauczok, C.S. Vetter‐Kauczok Department of Dermatology, University of Würzburg, Josef‐Schneider‐Str. 2, D‐97080 Würzburg, Germany E‐mail: benoit_s@klinik.uni‐wuerzburg.de Search for other works by this author on: Oxford Academic Google Scholar E.‐B. Bröcker E.‐B. Bröcker Department of Dermatology, University of Würzburg, Josef‐Schneider‐Str. 2, D‐97080 Würzburg, Germany E‐mail: benoit_s@klinik.uni‐wuerzburg.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 4, 1 October 2007, Pages 804–806, https://doi.org/10.1111/j.1365-2133.2007.08053.x Published: 01 October 2007
Critical Roles of Muscle-Secreted Angiogenic Factors in Therapeutic Neovascularization
Authors: Kaoru Tateno, Tohru Minamino, Haruhiro Toko, Hiroshi Akazawa, Naomi Shimizu, Shinichi Takeda, Takeshige Kunieda, Hideyuki Miyauchi, Tomomi Oyama, Katsuhisa Matsuura, Jun-ichiro Nishi, Yoshio Kobayashi, Toshio Nagai, Yoichi Kuwabara, Yoichiro Iwakura, Fumio Nomura, Yasushi Saito, Issei Komuro
Journal: Circulation Research (2006)

The discovery of bone marrow–derived endothelial progenitors in the peripheral blood has promoted intensive studies on the potential of cell therapy for various human diseases. Accumulating evidence has suggested that implantation of bone marrow mononuclear cells effectively promotes neovascularization in ischemic tissues. It has also been reported that the implanted cells are incorporated not only into the newly formed vessels but also secrete angiogenic factors. However, the mechanism by which cell therapy improves tissue ischemia remains obscure. We enrolled 29 “no-option” patients with critical limb ischemia and treated ischemic limbs by implantation of peripheral mononuclear cells. Cell therapy using peripheral mononuclear cells was very effective for the treatment of limb ischemia, and its efficacy was associated with increases in the plasma levels of angiogenic factors, in particular interleukin-1β (IL-1β). We then examined an experimental model of limb ischemia using IL-1β–deficient mice. Implantation of IL-1β–deficient mononuclear cells improved tissue ischemia as efficiently as that of wild-type cells. Both wild-type and IL-1β–deficient mononuclear cells increased expression of IL-1β and thus induced angiogenic factors in muscle cells of ischemic limbs to a similar extent. In contrast, inability of muscle cells to secrete IL-1β markedly reduces induction of angiogenic factors and impairs neovascularization by cell implantation. Implanted cells do not secret angiogenic factors sufficient for neovascularization but, instead, stimulate muscle cells to produce angiogenic factors, thereby promoting neovascularization in ischemic tissues. Further studies will allow us to develop more effective treatments for ischemic vascular disease.
Decreases in air pollutants may lead to lower cardiopulmonary mortality
Authors: A Bhowmik
Journal: Thorax (2003)

▴ Clancy L, Goodman P, Sinclair H, et al . Effect of air pollution control on death rates in Dublin, Ireland: an intervention study. Lancet2002;360:1210–4 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Air pollution, deaths, and the weather were compared for 72 months before and 72 months after the ban on coal sales in the city of Dublin on 1 … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DClancy%26rft.auinit1%253DL.%26rft.volume%253D360%26rft.issue%253D9341%26rft.spage%253D1210%26rft.epage%253D1214%26rft.atitle%253DEffect%2Bof%2Bair-pollution%2Bcontrol%2Bon%2Bdeath%2Brates%2Bin%2BDublin%252C%2BIreland%253A%2Ban%2Bintervention%2Bstudy.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252802%252911281-5%26rft_id%253Dinfo%253Apmid%252F12401247%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(02)11281-5&link_type=DOI [3]: /lookup/external-ref?access_num=12401247&link_type=MED&atom=%2Fthoraxjnl%2F58%2F1%2F36.atom [4]: /lookup/external-ref?access_num=000178708100010&link_type=ISI