tbuckley/cabot-search huggingface dataset:
Even Individuals Considered as Long-Term Nonprogressors Show Biological Signs of Progression After 10 Years of Human Immunodeficiency Virus Infection
Authors: Jean-Jacques Lefrère, Laurence Morand-Joubert, Martine Mariotti, Hubertus Bludau, Béatrice Burghoffer, Jean-Claude Petit, Françoise Roudot-Thoraval
Journal: Blood (1997)
Constant infusion schedule for adriamycin: a phase I-II clinical trial of a 30-day schedule by ambulatory pump delivery system.
Authors: J Lokich, A Bothe, T Zipoli, R Green, H Sonneborn, S Paul, D Philips
Journal: Journal of Clinical Oncology (1983)

Eighteen patients received a continuous intravenous infusion of adriamycin for 14-60 days in a phase I study in which the dose rates were escalated from 2 mg/sq m/day to 5 mg/sq m/day to establish the optimal dose to be delivered over a 30-day period. The drug was delivered via a tunneled subclavian catheter by a portable infusion pump (Cormed model ML-6) primed to provide a volume of diluted drug of 10 cc/day. Leukopenia and stomatitis were observed at 4 mg/sq m/day doses or greater in 50% of courses. At doses less than 4 mg/sq m/day, only 3/17 courses (18%) were associated with stomatitis. Partial alopecia developed in all patients, but less than 50% of scalp hair was affected. The cumulative dose of continuous infusion adriamycin at 30 days is comparable to the dose delivered by standard bolus intermittent schedules (60-90 mg/sq m g 21 days), but the adverse drug effects are eliminated or substantially reduced. Cardiac toxicity was assessed in selected patients treated to 450 mg/sq m or greater by cardiac biopsy and/or gated pool studies. No histopathologic lesions were noted in 3 patients receiving 450 mg/sq m or greater. The recommended daily dose rate of adriamycin in this protracted infusion regimen is 3 mg/sq m/day. The phase II study of this schedule and dose rate in 38 additional patients (a total of 52 evaluable patients) demonstrated objective responses in 1/9 soft tissue sarcoma, 1/3 mesothelioma, 1/3 hepatoma, and 2/13 breast cancer. Phase III studies of the protracted continuous infusion schedule for adriamycin are indicated in that clinical activity is demonstrated at a substantial reduction in toxicity. Pharmacologic studies expanding the existing data base are also necessary.
<i>March 1957 (Starbotton)</i>
Authors: Jeanette M. Smith
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Near drowning
Authors: M. Harries
Journal: BMJ (2003)

At times, cold can protect life as well as endanger it. There have been extraordinary examples of survival after long periods of submersion in ice cold water. Such cases highlight the differences in the approach to resuscitation that sets the management of people who nearly drown apart from all other circumstances in which cardiopulmonary arrest has occurred.​occurred.



Table 1

Essential factors concerning immersion incidents
Gene products of Escherichia coli: sequence comparisons and common ancestries.
Authors: B Labedan, M Riley
Journal: Molecular Biology and Evolution (1995)

Sequences of 1,862 chromosomally encoded Escherichia coli K12 proteins were examined to identify genes likely to have arisen by duplication of genes in an ancestral chromosome. The criteria for sequence relatedness were an alignment of at least 100 amino acid residues and a PAM distance (number of accepted point mutations per 100 residues separating two sequences) below 250. A total of 971 of the 1,862 proteins examined were found in 2,329 sequence-related pairs that met these criteria. Most proteins of the sequence-related pairs were related in cellular function, as judged by biochemical and/or physiological features. Many of the pairs of proteins could be grouped into sequence-related families. If such groupings were generated from ancestral genes by duplication and divergence events, through these sequence comparisons we can identify putative ancestral sequences of the present-day genes of E. coli and other organisms. The results suggest that the 971 paralogous genes could have been derived from only 204 ancestral genes. We have also shown that the process of duplication and divergence is not the exclusive mechanism of evolution of all E. coli genes. Indeed, the relationships among the sequences of multiple (in the sense of redundant) enzymes indicate that nearly half could have arisen either by convergent evolution or by lateral transfer. Therefore, not all functionally related genes need arise by duplication and divergence.
Inhibition of Immature Erythroid Progenitor Cell Proliferation by Macrophage Inflammatory Protein-1α by Interacting Mainly With a C-C Chemokine Receptor, CCR1
Authors: Shao-bo Su, Naofumi Mukaida, Jian-bin Wang, Yi Zhang, Akiyoshi Takami, Sinji Nakao, Kouji Matsushima
Journal: Blood (1997)
&lt;italic&gt;Brief Communication:&lt;/italic&gt; Human Antisera Detecting Leukemia-Associated Antigens on Autochthonous Tumor Cells
Authors: D L Mann, B Leventhal, R Halterman
Journal: JNCI Journal of the National Cancer Institute (1975)

Leukemia patients in remission were immunized with the RAJI lymphoid tissue culture cell lines. Four of 7 patients developed antibody to the immunizing cell as well as to allogeneic leukemia cells. Sera from 3 patients were tested against autochthonous tumor cells either frozen or obtained at the time of disease relapse. Patients' sera were cytotoxic to their own leukemia cells; however, this cytotoxicity was lost at the time of relapse.
Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis
Authors: Mark J.W. McPhail, Debbie L. Shawcross, Matthew R. Lewis, Iona Coltart, Elizabeth J. Want, Charalambos G. Antoniades, Kiril Veselkov, Evangelos Triantafyllou, Vishal Patel, Oltin Pop, Maria Gomez-Romero, Michael Kyriakides, Rabiya Zia, Robin D. Abeles, Mary M.E. Crossey, Wayel Jassem, John O’Grady, Nigel Heaton, Georg Auzinger, William Bernal, Alberto Quaglia, Muireann Coen, Jeremy K. Nicholson, Julia A. Wendon, Elaine Holmes, Simon D. Taylor-Robinson
Journal: Journal of Hepatology (2016)

Predicting survival in decompensated cirrhosis (DC) is important in decision making for liver transplantation and resource allocation. We investigated whether high-resolution metabolic profiling can determine a metabolic phenotype associated with 90-day survival.Two hundred and forty-eight subjects underwent plasma metabotyping by (1)H nuclear magnetic resonance (NMR) spectroscopy and reversed-phase ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry (UPLC-TOF-MS; DC: 80-derivation set, 101-validation; stable cirrhosis (CLD) 20 and 47 healthy controls (HC)).(1)H NMR metabotyping accurately discriminated between surviving and non-surviving patients with DC. The NMR plasma profiles of non-survivors were attributed to reduced phosphatidylcholines and lipid resonances, with increased lactate, tyrosine, methionine and phenylalanine signal intensities. This was confirmed on external validation (area under the receiver operating curve [AUROC]=0.96 (95% CI 0.90-1.00, sensitivity 98%, specificity 89%). UPLC-TOF-MS confirmed that lysophosphatidylcholines and phosphatidylcholines [LPC/PC] were downregulated in non-survivors (UPLC-TOF-MS profiles AUROC of 0.94 (95% CI 0.89-0.98, sensitivity 100%, specificity 85% [positive ion detection])). LPC concentrations negatively correlated with circulating markers of cell death (M30 and M65) levels in DC. Histological examination of liver tissue from DC patients confirmed increased hepatocyte cell death compared to controls. Cross liver sampling at time of liver transplantation demonstrated that hepatic endothelial beds are a source of increased circulating total cytokeratin-18 in DC.Plasma metabotyping accurately predicts mortality in DC. LPC and amino acid dysregulation is associated with increased mortality and severity of disease reflecting hepatocyte cell death.
Gefitinib-induced platelet-derived microparticle and ICAM-1 in Japanese patients with non-small cell lung cancer
Authors: S. Kanazawa, Y. Kinoshita, K. Yamaguchi, S. Nomura
Journal: Journal of Clinical Oncology (2006)

17056 Background: We recently discovered that platelet activation is observed in patients receiving gefitinib. Nomura et al. reported that activated platelets generated platelet-derived microparticle (PDMP) and this PDMP could induce adhesion molecules and an interaction between white blood cells and endothelial cells. Theaim of the present study was to identify the clinical significance between PDMP and intercellular adhesion molecule-1 (ICAM-1) in lung cancer patients receiving gefitinib. Methods: Patients with a diagnosis of non-small cell lung cancer were entered into this study. Blood samples were withdrawn before and one week and two weeks after the administration of gefitinib. PDMP and ICAM-1 were measured using an enzyme-linked immunosorbent assay kit. A total of 25 patients was recruited in the study. The characteristics of the study subjects were: age: 42–78 years (median: 68 years); gender: male vs. female = 14 vs. 11; tumor histology: adenocarcinoma vs. squamous cell carcinoma = 17 vs. 8. Nine patients were responders and the other 16 patients were non-responders. Results: The plasma concentration of PDMP significantly increased after receiving gefitinib (before vs. one week vs. two weeks = 14.1±12.0 U vs. 17.9±16.9 U (p&lt;0.05) vs. 14.6±12.0 U n = 25). The plasma concentration of ICAM-1 significantly increased after receiving gefitinib (before vs. one week vs. two weeks = 296.2±85.1 ng/ml vs. 319.4±78.9 ng/ml vs. 344.8±74.0 ng/ml (p&lt;0.05) n = 16). Conclusions: Platelets were activated by gefitinib therapy, and the effect of gefitinib is related to a reaction of not only blocked EGFR but also platelet activation and in part endothelial cells and leukocytes through activated platelets. The mechanisms underlying some adverse events in gefitinib-treated patients are poorly understood. Our results suggest that one of the mechanisms causing gefitinib-related adverse effects depends on platelet activation. No significant financial relationships to disclose.
Effect of Busulfan on Antibody Production and Skin Allograft Survival in the Rat&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;
Authors: G W Santos, P J Tutschka
Journal: JNCI Journal of the National Cancer Institute (1974)

Sprague-Dawley and Lewis (LEW) rats were given injections of sheep red blood cells at various times in relation to a single injection of busulfan (BU) [≈ 60% of mean lethal dose (LD50)] suspended in carboxymethyl cellulose. BU treatment raised saline agglutinin titers in SO rats regardless of the time of immunization in relation to BU treatment. LEW rats had this adjuvant effect even when supralethal doses of BU were given. Although not as great as adjuvant effects produced by BU alone, adjuvant effects were produced with carboxymethyl cellulose as well as with homogenates of spleens from BU-pretreated donors. LEW and (LEW × BN)F1 rats given skin allografts from BN, ACI, or F344 rats at various times in relation to a single dose of BU (≈ 60% of the LD50) did not show a lengthening or shortening of allograft survival. However, when skin grafts from BN rats were placed on LEW animals 4 hours after receiving the injection of BU, allograft survival was minimally, but significantly, shortened.
Cigarette Smoking in Women With Cancers of the Breast and Reproductive Organs2
Authors: J. A. Baron, T. Byers, E. R. Greenberg, K. M. Cummings, M. Swanson
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Cigarette Smoking in Women With Cancers of the Breast and Reproductive Organs Get access J. A. Baron, J. A. Baron Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Byers, T. Byers Search for other works by this author on: Oxford Academic PubMed Google Scholar E. R. Greenberg, E. R. Greenberg Search for other works by this author on: Oxford Academic PubMed Google Scholar K. M. Cummings, K. M. Cummings Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Swanson M. Swanson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 77, Issue 3, September 1986, Pages 677–680, https://doi.org/10.1093/jnci/77.3.677 Published: 01 September 1986 Article history Received: 29 October 1985 Accepted: 28 April 1986 Published: 01 September 1986
Unusual Presentations of Uncommon Tumors
Authors: Roderich E. Schwarz, Rob A. Fuller, Peiguo Chu
Journal: Journal of Clinical Oncology (2002)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.9.2403 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11981015 Unusual Presentations of Uncommon Tumors Case 2. Gastric Carcinoid Metastatic to the Liver Roderich E. SchwarzxRoderich E. SchwarzSearch for articles by this author , Rob A. FullerxRob A. FullerSearch for articles by this author , Peiguo ChuxPeiguo ChuSearch for articles by this author Show More City of Hope National Medical Center, Duarte, CA https://doi.org/10.1200/JCO.2002.20.9.2403 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
Can We Cure Limited Metastatic Breast Cancer?
Authors: Gabriel N. Hortobagyi
Journal: Journal of Clinical Oncology (2002)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.3.620 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11821439 Can We Cure Limited Metastatic Breast Cancer? Gabriel N. HortobagyixGabriel N. HortobagyiSearch for articles by this author Show More The University of Texas M.D. Anderson Cancer Center, Houston, TX https://doi.org/10.1200/JCO.2002.20.3.620 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
Efficacy and tolerability of gemcytabine plus docetaxel in patients with locally advanced or metastatic adenocarcinoma of the lung
Authors: M. Krzakowski, D. M. Kowalski, K. Zajda, T. Denisso, P. Jaskiewicz, W. Lasota, A. Janowicz-Zebrowska
Journal: Journal of Clinical Oncology (2006)

17134 Background: Chemotherapy prolongs survival of patients with advanced non-small cell lung cancer (NSCLC). Subanalysis of a phase III trial suggests better outcome of treatment with platinum and gemcytabine containing combinations in patients with adenocarcinoma. Also docetaxel is active in NSCLC. The aim of this phase II trial was to wvaluate the efficacy and tolerability of third generation doublet (GCB and DXL) in cheminaive patients with advanced adenocarcinoma of lung. Methods: Chemonaive patients with biopsy proven stage IIIB or IV adenocarcinoma of lung not suitable for curative radical treatment witk KPS 80–100 received 2 to 6 chemotherapy cycles (DXL 80 mg/m 2 day 1 plus GCB 1000 mg/m 2 day 1 and 8; every 21 days). Response rate and tolerability were the primary endpionts, while the overall survival and 1-year survival were secondary objectives. Results: Twenty eigth patients (15 women, 13 men) with median age 59,04 (range 40–74) were treated. Twenty three patients was analysed. Stage IV was found in 23 (95.8%) and stage IIIB in 1 (4.2%) patients. Partial response was achiwed in 9 (37,5%), stable disease in 12 (50%) and pregressive disease in 3 (12,5%) patients. Median time to progression was 8, 37 months (range: 1.5–14 months). Median overall survival was 12,87 months (range: 4–35 months). Eleven (11) patients received second-line therapy (6-RT, 11-CTH). All patients received 94 cycles of chemotherapy (range: 2, median 3,9). Total dose of docetaxel on each patients was fro 120 to 960 mg (median 556 mg). Total dose of gemcytabine on each patients was from 2100 mg to 21000 mg (median 10475 mg). Treatment toxicicy presents on the table . Conclusions: First line gemcytabine and docetaxel containing chemotherapy is effective palliative treatment for patients with advanced AC of the lung. Toxicity was within acceptable limits. [Table: see text] No significant financial relationships to disclose.
Safe Administration of Ambulatory Chemotherapy Center
Authors: Shinichiro Taira, Motohide Shimazu, Mitsuhiro Hayashi, Hiroyuki Miura, Eiji Nakajima, Tetsuo Matsumoto, Toshimo Katagami, Kazuhiro Nakamura, Tetsuo Nagatani, Osamu Iwase
Journal: Annals of Oncology (2014)
Ultrastructural Changes in the Nuclear Envelope During Mitosis of Chinese Hamster Cells: A Proposed Mechanism of Nuclear Envelope Reformation
Authors: Lee S. Cha, Herbert Weinfeld, Avery A. Sandberg
Journal: JNCI Journal of the National Cancer Institute (1974)

Direct fixation with chrome-osmium of mitotic Chinese hamster cells revealed the presence, close to the chromatin and chromosomes, of 3 elements not made visible by double fixation with glutaraldehyde followed by osmium tetroxide: highly electron-dense material, granules, and microfibers. The highly electron-dense material was probably of nucleolar origin. The granular materials surrounded the entire chromatin mass in late prophase after the nuclear envelope (NE) had disappeared. In metaphase and early anaphase, the granules were distributed uniformly along the periphery of the chromosomes. Most granules disappeared in late anaphase before new NE formed. Microfibers organized in bundles appeared during dissolution of the NE in prophase and were in the region that had been occupied by the old NE. Similar microfibers were also present in late anaphase and early telophase where new NE was about to be formed. In prophase and early metaphase, small vesicles were among the perichromosomal granules. Such vesicles were scarcely detectable in metaphase but reappeared near the chromosomesin late anaphase and in early telophase in the regions where the NE was about to be formed. It is suggested that a portion of the granules and microfibers are residues of the old NE and might be partially reutilized in formation of new NE. A prominent feature in late anaphase and early telophase was the spatial association of mitochondria, vesicles, new NE, and chromatin in that order. It is suggested that mitochondria play an active role in formation of the vesicles which then coalesce to form the new NE.
Rules on lobbying threaten to gag tax funded researchers
Authors: Anne Gulland
Journal: BMJ (2016)

Health researchers and campaigners have warned that a move by the UK government to stop lobbying by taxpayer funded bodies risked stifling research that questioned government policy.

Earlier this month the Cabinet Office announced that from May this year a new clause would be inserted into all grant agreements requiring that organisations that receive government grants spend their money on “improving people’s lives and good causes.” Guidance accompanying the announcement said that government grants should not be spent on campaigns to influence parliament, government, or political parties, and nor should they “influence legislative or regulatory action.”1

It added that grant recipients were still free to engage in lobbying but should not use public money to do so. Any organisation that breached the clause may have its grant cancelled or be forced to repay it.

Qualifications could be issued only in “exceptional cases,” for example if a …
Cannabis use in psychotic patients is linked to worse outcomes
Authors: Jacqui Wise
Journal: BMJ (2016)

Cannabis use among patients with first episode psychosis is associated with substantially worse clinical outcomes, a large study published in BMJ Open has found.1

Psychotic patients with a history of cannabis use were more likely to be admitted to hospital, to require compulsory admission, and to spend an extra 35 days in hospital in the five years after their first episode, the study found. Cannabis use was also linked to prescription of several different antipsychotic drugs during the follow-up period, suggesting treatment failure.

The five year …
Abstract 15324: Intracardiac Pressure Mismatch is Associated With Renal Recovery Following Medical Therapy in Acute Decompensated Heart Failure
Authors: Justin L Grodin, Matthias Dupont, Wilfried Mullens, David O Taylor, Randall C Starling, W. H. Wilson Tang
Journal: Circulation (2013)

Background: Venous congestion is a crucial factor for worsening renal function (WRF) in the setting of acute decompensated heart failure (ADHF). However, the relationship between elevated left- and...
CONTINUOUS ELECTROCARDIOGRAPHIC RECORDINGS AND SERIAL CHANGES OF VARIOUS SERUM ENZYMES IN A PATIENT WITH VARIANT FORM OF ANGINA PECTORIS
Authors: Ikuhiro Yamasawa, Yoshitsugu Nohara, Masao Takayasu, Michinari Morimoto, Sadamu Hiraide, Takero Sugiura
Journal: Circulation (1974)

A patient with a variant form of angina pectoris was subjected to continuous electrocardiographic recordings. This case was different from the variant form of angina pectoris as described by Prinzmetal et al., in that the ST segment elevation in the leads reflected the ischemic area during his chest pain, not only at rest, but also at the time of effort. With the cessation of pain, the ST segment rapidly returned to the appearance prior to the onset of an attack. This case also demonstrates the interesting serial changes of electrocardiograms taken by continuous electrocardiographic recordings during anginal attacks. The serial alteration of various serum enzymes in this case remained within the normal range except for the slightly transient increase of SCPK activity. In this case, practolol therapy was effective in alleviating the anginal attacks.
Efficacy, Safety, Tolerability, and Pharmacokinetics of Human Immune Globulin Subcutaneous, 20% (IGSC 20%): Final Analysis of a Phase 2/3 Study in Patients with Primary Immunodeficiency Disease (PIDD) in North America
Authors: Daniel Suez, Isaac Melamed, Iftikhar Hussain, Mark R. Stein, Sudhir Gupta, Kenneth Paris, Sandor Fritsch, Christelle Bourgeois, Heinz Leibl, Barbara McCoy, Leman Yel
Journal: Journal of Allergy and Clinical Immunology (2016)