tbuckley/cabot-search huggingface dataset:
Drug interaction between alpha interferon and erythropoietin.
Authors: R G Desai
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.5.893 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2016633 Drug interaction between alpha interferon and erythropoietin. R G DesaixR G DesaiSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.5.893 PDF "Drug interaction between alpha interferon and erythropoietin.." Journal of Clinical Oncology, 9(5), p. 893© 1991 by American Society of Clinical Oncology
Adverse events during treatment for latent tuberculosis infection
Authors: Claudia C. Dobler, Guy B. Marks
Journal: European Respiratory Journal (2011)

Aim:  To determine adverse events in patients taking treatment for latent tuberculosis infection (LTBI).   Methods:  Records of all patients who received treatment for LTBI at the Chest Clinic of a large tertiary hospital between 01/2000 and 04/2008 were reviewed. An adverse event was defined as any change in health status that led to treatment interruption or cessation. Liver function tests were not performed routinely during follow-up, except when the patient was considered to be at an increased risk of developing hepatitis.   Results:  Of 201 patients in whom treatment for LTBI was initiated 143 (71%) received isoniazid for 6 months, 32 (15%) received a combination of isoniazid and rifampicin for 6 months, and the remainder were treated with different regimens. Their mean (SD) age was 21 (17) years and 44% were male. Nineteen patients (9.5%) experienced an adverse event. Seven patients developed a rash, four had lethargy and/or mood disorders, three had subclinical hepatitis, four experienced severe nausea, vomiting and/or other gastrointestinal symptoms and three had features of peripheral neuropathy. In eight patients who experienced an adverse event medication was temporarily ceased and then re-started without change; in four the treatment regimen was changed; and in seven the treatment was ceased completely. The risk of adverse events was not significantly related to age, sex, drug regimen (single drug versus combination therapy) or baseline transaminase levels.   Conclusions:  In this cohort almost 1 in 10 patients on treatment for LTBI experienced an adverse event. Although the adverse events were generally mild to moderate, this risk has to be taken into account when deciding whether to advise treatment for LTBI.
Parenteral Nutrition via Peripheral Veins: A Feasibility Study
Authors: A Wilson, A W Goode, C J C Kirk, M Sugden
Journal: Journal of the Royal Society of Medicine (1987)

Twenty patients who had undergone uncomplicated surgery of moderate severity were randomly allocated to two groups (both n = 10) who were fed using a peripheral vein for up to six days. Group I received, each day, a nutrient solution providing 10 grams of nitrogen as Perifusin (E Merck Ltd) and 1400 calories as dextrose and Intralipid (Kabivitrum Ltd) with an osmolality of 490 mosmol/kg. Group II received only 15 grams of nitrogen per day as Perifusin with an osmolality of 376 mosmol/kg. The mean (± s.e. mean) nitrogen balance over the study was similar in both groups, in Group I being −1.23 ± 0.89, and in Group II being −1.05 ± 1.08 g ( P &gt; 0.05 Mann-Whitney U test). The nutrient mixture given to Group I resulted in elevated levels of serum 3-hydroxybutyrate and lower levels of serum non-esterified fatty acids. These data suggest that lipolysis and ketogenesis were suppressed. There was no significant difference in serum lactate levels in either group. Venous thrombophlebitis at the infusion site was assessed daily using Maddox's criteria, with a minimal degree of inflammation occurring in either group. This preliminary study suggests that a total parenteral feeding regimen may be designed for peripheral vein infusion. Further studies are indicated.
Abstract 6: Therapeutic Angiogenesis by Human CD34+ Hematopoietic Stem Cells via Exosomes-Mediated MicroRNA Transfer
Authors: Susmita Sahoo, Rajesh Gupta, Tina Thorne, Sol Misener, Aiko Ito, Douglas W Losordo, Douglas E Vaughan
Journal: Circulation Research (2012)

Introduction: Locally transplanted human CD34+ hematopoietic stem cells have stimulated neovascularization in preclinical studies and have been associated with functional improvements in phase I and II clinical trials of patients with ischemic cardiovascular diseases. Recently, we have demonstrated that membrane-bound nano-vesicles called exosomes are one of the primary pro-angiogenic components of human CD34+ cell paracrine secretion that induced angiogenesis independently of the cells. Here, we hypothesize that the functional benefits associated with CD34+ cell therapy are primarily mediated by the secretion of exosomes (Exo), and that CD34+ Exo transfer pro-angiogenic microRNAs to promote angiogenesis and ischemic tissue repair. Methods and Results: Therapeutic potential of CD34+ Exo isolated from adult human peripheral blood-derived CD34+ cells was evaluated in a mouse model of hind limb ischemia (HLI). Similar to CD34+ cells, administration of CD34+ Exo from equal number of cells induced angiogenesis and tissue repair; it significantly improved perfusion (ratio: 1.01±0.04 v 0.57±0.1, P&lt;0.05), increased capillary density (1.8±0.3/HPF v 0.9±0.1/HPF, p&lt;0.001) and prevented ischemic leg amputation (16% v 100%), compared to Exo from non-angiogenic, CD34+ cell-depleted-mononuclear cells (MNC Exo). Our microarray data and confirmatory tests revealed that unlike MNC Exo, CD34+ Exo are enriched in pro-angiogenic miRNAs such as miR-126. Flow cytometry and live confocal imaging demonstrated that Cy3-tagged miRNA in CD34+ Exo is directly transferred to endothelial cells in vitro and in ischemic tissues in vivo; concurrent loss of function gain of function studies prove that direct transfer of miR-126 is crucial for CD34+ Exo-induced angiogenesis and functional recovery. To address whether exosome secretion is needed for miR-126 transfer, we are exploring the effect of inhibition of exosome secretion from CD34+ cells. Conclusion: CD34+ exosomes transfer the pro-angiogenic miR-126 to endothelial cells in the ischemic tissues to induce angiogenesis and ischemic tissue repair. Our study illustrates a mechanism of stem cell communication involving intercellular traffic of miRNAs via exosomes to induce functional recovery.
The robustness of two phylogenetic methods: four-taxon simulations reveal a slight superiority of maximum likelihood over neighbor joining.
Authors: J P Huelsenbeck
Journal: Molecular Biology and Evolution (1995)

The robustness (sensitivity to violation of assumptions) of the maximum-likelihood and neighbor-joining methods was examined using simulation. Maximum likelihood and neighbor joining were implemented with Jukes-Cantor, Kimura, and gamma models of DNA substitution. Simulations were performed in which the assumptions of the methods were violated to varying degrees on three model four-taxon trees. The performance of the methods was evaluated with respect to ability to correctly estimate the unrooted four-taxon tree. Maximum likelihood outperformed neighbor joining in 29 of the 36 cases in which the assumptions of both methods were satisfied. In 133 of 180 of the simulations in which the assumptions of the maximum-likelihood and neighbor-joining methods were violated, maximum likelihood outperformed neighbor joining. These results are consistent with a general superiority of maximum likelihood over neighbor joining under comparable conditions. They extend and clarify an earlier study that found an advantage for neighbor joining over maximum likelihood for gamma-distributed mutation rates.
Abstract 304: Global Transcriptional Effects of Vitamin A Deficiency on the Postnatal Heart
Authors: Cristi L Galindo, Truc-Linh Tran, Xuyang Peng, Douglas B Sawyer, Mary Asson-Batres
Journal: Circulation Research (2012)

Vitamin A (VA) is the chemical precursor of retinoic acid (RA), which is critical for embryonic development and for growth, immunity, metabolism, and cell differentiation in postnatal regenerating systems such as skin, sensory organs, and stem cell niches in the brain. VA is also essential for embryonic heart development, and we hypothesized that Vitamin A might exert an effect on the postnatal heart similar to what is observed for other tissues. Here, we report the global transcriptional profiles of wild-type (WT) mice fed a VA sufficient diet (VAS) compared with retinyl acyl transferase (LRAT) knock-out mice fed either a VAS or VA deficient (VAD) diet. Knockout of the LRAT gene alone was sufficient to induce differential expression of 576 genes relative to WT. Feeding LRAT mutant mice a VAD diet resulted in a change in the relative expression levels of 257 genes relative to LRAT mutant mice fed a VAS diet. As expected, we observed transcriptional alterations related to Vitamin A metabolism, including an increase in the gene encoding cellular retinoid binding protein 7 and down-regulation of the retinol metabolic enzymes Cy1a2 and Cyp2a4. Importantly, several cardiac genes not previously known to require VA were perturbed, including the gene encoding B-type natriuretic peptide, which was down-regulated in mutant mice irrespective of diet, and A-type natriuretic peptide, which was decreased only in mice fed the VAD diet. There was also a striking effect of VAD on genes important for immune responses, which could have an impact on the wound healing process subsequent to injury of the heart. This is consistent with recent evidence that showed that Vitamin A deficiency influences post-infarct ventricular remodeling in rats. In summary, this is the first microarray study of Vitamin A deficiency in the postnatal heart, which suggests mechanisms by which Vitamin A depletion may alter myocardial maintenance and repair after injury.
Determinants of Susceptibility and Resistance to Feline Leukemia Virus Infection. I. Role of Macrophages23
Authors: Edward A. Hoover, Jennifer L. Rojko, Pamela L. Wilson, Richard G. Olsen
Journal: JNCI Journal of the National Cancer Institute (1981)

Abstract The role of autochthonous peritoneal feline macrophages (Mθ) in the age-related resistance of cats to feline leukemia virus (FeLV) was investigated by a study of the functional properties and FeLV susceptibility of Mθ from kittens and adult cats and the effect of hydrocortisone (HC) and silica on Mθ-FeLV interactions. Although the phagocytic functions of isolated Mθ from kittens and adults were equivalent, the mean FeLV susceptibility of Mθ from kittens was five times that of Mθ from adult cats, thus establishing a direct correlation between the age-related susceptibility of cats and Mθ from cats to FeLV. Mθ of viremic cats were found to be infected with FeLV in vivo; virus titers were slightly higher than those obtained after in vitro infection of Mθ. Mθ from cats that had experienced regressive FeLV infection were not significantly more resistant to FeLV infection in vitro than were Mθ from naive adult specific-pathogen-free cats. HC, which has been shown to enhance the in vivo FeLV susceptibility of cats, also enhanced the permissiveness of Mθ from cats to FeLV in vitro (600-fold for Mθ from adult cats and 200-fold for Mθ) from kittens. Mθ permissiveness to FeLV was highly sensitive to HC and occurred in Mθ infected in vivo or in vitro. In parallel with the effect of HC on the natural resistance of cats to FeLV, administration of silica before virus inoculation also markedly enhanced the FeLV susceptibility of adult cats. Silica was toxic for isolated Mθ but not for lymphocytes in vitro, and silica produced monocytopenia and neutrophilia, delayed skin allograft rejection, and augmented feline oncovirus-associated cell membrane antigen antibody responses in vivo. These experiments indicate that Mθ were linked to the natural resistance of cats to FeLV and that the temporary elimination of Mθ functions (e.g., by silica) and/or the conversion of the Mθ-FeLV relationship from a nonpermissive to a permissive state (e.g., by corticosteroids) resulted in failure of early virus containment, in persistent virus amplification in hemolymphatic tissues, and in subsequent FeLV-related proliferative or antiproliferative disease.
Prognostic Value Of LMP1, CLA, NK-Cell Origin, and Pretreatment Bone Marrow EBER-ISH In Localized NK/T-Cell Lymphoma Prospectively Treated With Concurrent Chemoradiotherapy: An Ancillary Study Of Japan Clinical Oncology Group (JCOG) 0211
Authors: Motoko Yamaguchi, Katsuyoshi Takata, Tadashi Yoshino, Naoki Ishizuka, Masahiko Oguchi, Yukio Kobayashi, Yasushi Isobe, Kenichi Ishizawa, Nobuko Kubota, Kuniaki Itoh, Noriko Usui, Kana Miyazaki, Izumi Wasada, Shigeo Nakamura, Yoshihiro Matsuno, Kazuo Oshimi, Tomohiro Kinoshita, Kunihiro Tsukasaki, Kensei Tobinai
Journal: Blood (2013)
Carboplatin with etoposide in patients with extrapulmonary “aggressive” neuroendocrine carcinoma.
Authors: G. Di Meglio, C. Massacesi, D. Radice, S. Boselli, G. Pelosi, M. Squadroni, F. Spada, K. Lorizzo, F. G. De Braud, N. Fazio
Journal: Journal of Clinical Oncology (2010)

e13072 Background: Extrapulmonary rapidly progressive neuroendocrine carcinomas (NECs) clinically resemble a small cell lung cancer (SCLC), where carboplatin has been reported as active as cisplatin, combined with etoposide. We studied carboplatin/etoposide combination in patients with extrapulmonary clinically/biologically aggressive NECs. Methods: Twenty consecutive patients with histological diagnosis of non-lung non-Merkel cell carcinoma advanced NECs were enrolled, as long as they had a tumor with one or more of the following aspects: poorly differentiated, Ki67 > 20%, or a clear radiological progression within the last three months. Response rate and toxicity were the primary, and time to progression, and overall survival secondary endpoints. Results: All patients were treated with etoposide 100 mg/m2/day over three days, and carboplatin AUC 4-6 day 1, every three weeks. Median age was 60 years (range 15-78). Nine were untreated and 11 pretreated. Three complete responses (15%), 7 partial responses (35%), 4 stable diseases (20%), and 6 progressive diseases (30%) were observed. The most frequent grade 3-4 toxicity was neutropenia (65%), only in one case febrile. All type grade 3-4 toxicities were less than 5%, without clinical consequences. Time to progression was 9 months (95% CI: 4-14), and overall survival 20 months (95% CI: 14-38). Conclusions: Carboplatin/etoposide combination is active and well-tolerated in patients with aggressive extra-pulmonary NECs. Therefore carboplatin could be considered as an alternative when some cisplatin toxicity should be avoided. Furthermore, based on these results a prospective head-to-head carboplatin/cisplatin comparison is warranted in this setting. No significant financial relationships to disclose.
A Reference Handbook of the Medical Sciences, Embracing the Entire Range of Scientific and Practical Medicine and Allied Science.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of transcription factor Sp1 predicts the microvessel density of human gastric cancer
Authors: L. Wang
Journal: Journal of Clinical Oncology (2005)

4148 Background: Angiogenic behavior is a critical aspect of cancer biology and subject to regulation by multiple molecular pathways that are under the control of transcription factors. Improved understanding of how transcription factors affect cancer biology may lead to improved ability to predict clinical outcome and discovery of novel therapeutic strategies. Because the transcription factor Sp1 regulates multiple genes important to angiogenesis, we evaluated the relationship between Sp1 expression and microvessel density (MVD) as well as their effect on cancer patient survival. Methods: The expression of Sp1 and vascular endothelial growth factor (VEGF) and status of MVD was determined by immunohistochemistry using archival tissues of 86 cases of resected human gastric cancer. Results: We found that MVD correlated highly with Sp1 expression (P < 0.01). Patients with high Sp1 expression were 12 times more likely to have high MVD expression than were those with negative Sp1 expression. In contrast, VEGF, a major angiogenic factor, was not as strong as Sp1 in predicting MVD. In univariate survival analyses, both elevated Sp1 expression (P = 0.007) and high MVD expression (P = 0.036) were associated with inferior survival. However, when Sp1 expression, MVD expression, disease stage, completeness of resection, histology, and patient age were entered into a Cox proportional hazards model, only strong Sp1 expression (P = 0.047) and advanced stage (P < 0.01) were independently prognostic of poor survival. Conclusions: Sp1 expression was a better predictor of clinical outcome than MVD, supporting the hypothesis that Sp1 impacts gastric cancer development and progression through its downstream target molecules, including vascular endothelial growth factor and various aspects of cancer biology, including angiogenesis. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration American Cancer Society
P-200 Real time image of mitochondria in living colon cancer tissues using probe based multiphoton microscopy
Authors: E.S. Kim, I.K. Yoo, S.H. Kim, J.M. Lee, H.S. Choi, B. Keum, Y.T. Jeen, H.J. Chun, B.R. Cho
Journal: Annals of Oncology (2015)
Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease
Authors: M Llopis, A M Cassard, L Wrzosek, L Boschat, A Bruneau, G Ferrere, V Puchois, J C Martin, P Lepage, T Le Roy, L Lefèvre, B Langelier, F Cailleux, A M González-Castro, S Rabot, F Gaudin, H Agostini, S Prévot, D Berrebi, D Ciocan, C Jousse, S Naveau, P Gérard, G Perlemuter
Journal: Gut (2015)

<h3>Objective</h3> There is substantial inter-individual diversity in the susceptibility of alcoholics to liver injury. Alterations of intestinal microbiota (IM) have been reported in alcoholic liver disease (ALD), but the extent to which they are merely a consequence or a cause is unknown. We aimed to demonstrate that a specific dysbiosis contributes to the development of alcoholic hepatitis (AH). <h3>Design</h3> We humanised germ-free and conventional mice using human IM transplant from alcoholic patients with or without AH. The consequences on alcohol-fed recipient mice were studied. <h3>Results</h3> A specific dysbiosis was associated with ALD severity in patients. Mice harbouring the IM from a patient with severe AH (sAH) developed more severe liver inflammation with an increased number of liver T lymphocyte subsets and Natural Killer T (NKT) lymphocytes, higher liver necrosis, greater intestinal permeability and higher translocation of bacteria than mice harbouring the IM from an alcoholic patient without AH (noAH). Similarly, CD45<sup>+</sup> lymphocyte subsets were increased in visceral adipose tissue, and CD4<sup>+</sup>T and NKT lymphocytes in mesenteric lymph nodes. The IM associated with sAH and noAH could be distinguished by differences in bacterial abundance and composition. Key deleterious species were associated with sAH while the <i>Faecalibacterium</i> genus was associated with noAH. Ursodeoxycholic acid was more abundant in faeces from noAH mice. Additionally, in conventional mice humanised with the IM from an sAH patient, a second subsequent transfer of IM from an noAH patient improved alcohol-induced liver lesions. <h3>Conclusions</h3> Individual susceptibility to ALD is substantially driven by IM. It may, therefore, be possible to prevent and manage ALD by IM manipulation.
Abstract 12326: Postoperative Atrial Fibrillation Impacts One Year Clinical Outcomes and Costs: The VA ROOBY Trial
Authors: G. Hossein Almassi, Todd H Wagner, Brack Hattler, Joseph F Collins, Jacquelyn Quin, Ramin Ebrahimi, Frederick L Grover, Muath Bishawi, Brendan M Carr, A L Shroyer
Journal: Circulation (2013)

Purpose: Costs and clinical outcomes were compared for CABG patients with and without new onset of postoperative atrial fibrillation (POAF). Methods: In a multi-center, randomized trial comparing o...
Phase Ib Dose-Escalation Study of the Akt Inhibitor Ipatasertib (Ipat) with Paclitaxel (P) in Patients (Pts) with Advanced Solid Tumors
Authors: S.J. Isakoff, J.R. Infante, D. Juric, W.Y. Chan, S. Jia, L. Musib, J. Zhu, R. Meng, P.H. Patel, J.C. Bendell
Journal: Annals of Oncology (2014)