tbuckley/cabot-search huggingface dataset:
Specific Colony Inhibition by Human Lymphoma Cells on an Established Human Lymphoma Cell Line
Authors: B. Drewinko, Giora Mavligit, Ulo Ambus, Carol Pritchett, Jordan Gutterman, Evan Hersh
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Specific Colony Inhibition by Human Lymphoma Cells on an Established Human Lymphoma Cell Line Get access B. Drewinko, B. Drewinko 2Department of Clinical Chemistry and Laboratory Medicine, The University of Texas at Houston M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025 Search for other works by this author on: Oxford Academic PubMed Google Scholar Giora Mavligit, Giora Mavligit 3Department of Developmental Therapeutics, The University of Texas at Houston M. D. Anderson Hospital and Tumor Institute Search for other works by this author on: Oxford Academic PubMed Google Scholar Ulo Ambus, Ulo Ambus 3Department of Developmental Therapeutics, The University of Texas at Houston M. D. Anderson Hospital and Tumor Institute Search for other works by this author on: Oxford Academic PubMed Google Scholar Carol Pritchett, Carol Pritchett 2Department of Clinical Chemistry and Laboratory Medicine, The University of Texas at Houston M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77025 Search for other works by this author on: Oxford Academic PubMed Google Scholar Jordan Gutterman, Jordan Gutterman 3Department of Developmental Therapeutics, The University of Texas at Houston M. D. Anderson Hospital and Tumor Institute Search for other works by this author on: Oxford Academic PubMed Google Scholar Evan Hersh Evan Hersh 3Department of Developmental Therapeutics, The University of Texas at Houston M. D. Anderson Hospital and Tumor Institute Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 4, October 1973, Pages 1377–1378, https://doi.org/10.1093/jnci/51.4.1377 Published: 01 October 1973 Article history Received: 13 June 1973 Accepted: 11 July 1973 Published: 01 October 1973
Health challenges of war and peace
Authors: Jacqui Thornton
Journal: BMJ (2016)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Health challenges of war and peace Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Response to Strous et al.: A Focus on Kraepelin’s Clinical Research Methodology
Authors: Kenneth S. Kendler, Eric J. Engstrom
Journal: American Journal of Psychiatry (2016)

Issues," Kraepelin proclaimed that "dreamers, poets, swindlers and Jews" possess "distinctly hysterical traits" and fall outside the bounds of normality, adding that Jews exhibit "frequent psychopathic disposition."These tendencies, he noted, are most importantly accompanied by "their harping criticism, their rhetorical and theatrical abilities, and their doggedness and determination" (4).Kraepelin also stated that "the preponderant influence of the Jewish spirit on German science, as is unfortunately wielded ever more intensely, appeared to me to be a serious danger" (5).Kraepelin was clearly guilty of profound boundary violations, allowing his clinical work and academic pursuits to be influenced by a right-wing socio-political agenda-an agenda that led psychiatrists, for the first time, to exterminate their patients during the Nazi era.This thinking began early on with his writings on "crime as a social disease"; with his attribution of criminal acts to "congenital inferior predisposition"; and with his membership in the nationalistic, extreme-right "Committee for the Rapid Subjugation of England" (4).His views later progressed to a multitude of statements regarding his dreams for a more authoritarian rule in his German fatherland, with Shepherd referring to his writings and lectures as displaying "disturbing overtones of proto-fascism" (4).Kraepelin was considered to be one of the foremost campaigners against homosexuality, stating that "homosexuality had to be fought prophylactically," and he suggested the age of consent be raised to protect young people from homosexuals (6), viewing homosexuality as a disturbance based on degeneration (7).Hence, he openly promulgated views of another psychiatrist, Alfred Hoche, who coauthored The Permission to Destroy Life Unworthy of Life.Kraepelin believed that "reasonable policies of racial hygiene" (verstandige rassenhygiene) should serve as the solution to Germany's problems of "degeneration" (8), suggesting that cultural influences add to the decline and weakening of the "race."Kraepelin contributed fundamentally to the ideological basis of racial hygiene in Germany.Gaupp proclaimed that Kraepelin's work "comprised nothing less than the foundation of all Nazi racial hygiene laws" (9).Kraepelin is neither a generative forefather nor a great icon, as history looks at his views.Kraepelin may be the father of psychiatric eugenics; however, we dispute declaring him the forefather of a field dedicated to the ethical caring and management of long-suffering individuals striving to recover and reclaim meaningful roles and functions.
Enhancement of the Infectivity of Simian Virus 40 Deoxyribonucleic Acid With Diethylaminoethyl-Dextran<xref ref-type="fn" rid="FN2">2</xref>
Authors: James H. McCutchan, Joseph S. Pagano
Journal: JNCI Journal of the National Cancer Institute (1968)

The infectivity of viral RNA for mammalian cells in culture is greatly enhanced by diethylaminoethyl-dextran (DEAE-D). In this work a similar enhancing effect is shown for the infectious DNA of simian virus 40 (SV40). This phenomenon has enabled the development of a sensitive plaque method for the assay of infectious viral DNA; the reliability of the assay is in part accounted for by elimination of the need for exposure of the assay cells to hypertonic media. DEAE-D in Tris-buffered isosmolar media in concentrations of from 100 to 3000 μg/ml increases the infectivity of SV40 DNA up to 100,000 times. With DEAE-D's of molecular weight 26,000 to 2,000,000, DNA infectivity was directly related to molecular weight of DEAE-D. Paradoxically, DEAE-D produced a 20-fold reduction in infectivity of intact SV40. The degree of inhibition also depended on the molecular weight of DEAE-D, the number of SV40 plaques being inversely related to molecular weight. Since as much as 0.1% of viral infectivity can be recovered in the extracted DNA, it is now possible to prepare SV40 DNA with an infectivity titer high enough to initiate synchronous infection of all the cells in a culture.
Surgical treatment for lung metastases in patients with colorectal cancer
Authors: Adam Rzechonek, Jerzy Kolodziej, Marek Lubicz
Journal: European Respiratory Journal (2011)

Introduction:  The paper presents a history of surgical treatment for lung metastases from colorectal cancer and subsequently an analysis of the treatment results, presenting some differences of lung metastasectomy.   Materials and methods:  A review of the literature from the years 2000-2010 for the resection of metastatic tumors of colorectal cancer and our experience and results from the material of 60 patients operated in our unit in 2004-2007.   Results:  Pulmonary metastasectomy of the secondary lesion of the colon gives the best results in cases of primary low pathological staging of a resectable primary colorectal cancer (T1 to T2 preferably limited to 3 number of lung metastases and/or a one metastasis to the liver disease in free time exceeding 36 months and the normal level of intestinal-embryonic marker.(CEA). Conversely-factors pleading for the surgical resection renouncement for metastases are: medium and high degree of advanced colorectal cancer (T3-4, N1-2), multiple metastases to the lung or liver disease-free time of less than 12 months and an increase in serum CEA (above 10 ng/ml.   Conclusion:  1. Results of surgical treatment of metastatic colorectal cancer to encourage a wider patient eligibility, taking into account prognostic factors. 2. Decisions about the way of surgical treatment for metastatic disease should be taken based on the assessment of the patient (organ function), number of metastases, and the value of CEA. 3. Regardless of the primary cancer focus, the G feature of differentiation, the number and size of metastases surgical resection extend patients life.
"PENNY WISE, POUND FOOLISH."
Journal: JAMA (1888)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Empirical test of Vaillant's hierarchy of ego functions
Authors: J R Battista
Journal: American Journal of Psychiatry (1982)

Vaillant (I , 2) hypothesized a four-level hierarchy of ego functions based on psychoanalytic psychology. The first, most disturbed level comprises the ‘ ‘narcissistic” (1) or “psychotic” (2) mechanisms ofdenial of reality, delusional projection, and distortion. The second level is characterized by ‘ ‘immature’ ‘ mechanisms: schizoid fantasy, projection, hypochondniasis, passive-aggressive behavior, and acting out. The third level is characterized by the ‘ ‘neurotic’ ‘ mechanisms of intellectualization, repression, reaction formation, displacement, and dissociation. The fourth, most healthy level comprises ‘ ‘mature’ ‘ mechanisms: sublimation, altruism, suppression, anticipation, and humon.
News coverage of clinical research
Authors: Andrew Grey, Michael T M Wang, Mark J Bolland
Journal: BMJ (2016)

We share McCartney’s concerns about health reporting.1 Media reports of research findings provide “impact” for academics and institutions, increase journals’ visibility and status, and accrue customers for news agencies. However, poor quality reporting causes unwarranted alarm or unrealistic expectations, promotes ineffective or unsafe health behaviours, and decreases faith in medical research when subsequent …
Smash and DASH with Cas9
Authors: Vijay Ramani, Jay Shendure
Journal: Genome biology (2016)

DeRisi and colleagues present a creative application for Cas9 in vitro, using it to deplete unwanted sequence from DNA libraries. It seems plausible that the in vitro use of CRISPR/Cas9 has unrealized potential to revolutionize the practice of molecular biology well beyond genome editing.
Docetaxel As Monotherapy or Combined With Ramucirumab or Icrucumab in Second-Line Treatment for Locally Advanced or Metastatic Urothelial Carcinoma: An Open-Label, Three-Arm, Randomized Controlled Phase II Trial
Authors: Daniel P. Petrylak, Scott T. Tagawa, Manish Kohli, Andrea Eisen, Christina Canil, Srikala S. Sridhar, Alexander Spira, Evan Y. Yu, John M. Burke, David Shaffer, Chong-Xian Pan, Jenny J. Kim, Jeanny B. Aragon-Ching, David I. Quinn, Nicholas J. Vogelzang, Shande Tang, Hui Zhang, Christopher T. Cavanaugh, Ling Gao, John S. Kauh, Richard A. Walgren, Kim N. Chi
Journal: Journal of Clinical Oncology (2016)

Purpose This trial assessed the efficacy and safety of docetaxel monotherapy or docetaxel in combination with ramucirumab (vascular endothelial growth factor receptor 2 antibody) or icrucumab (vascular endothelial growth factor receptor 1 antibody) after progression during or within 12 months of platinum-based regimens for patients with locally advanced or metastatic urothelial carcinoma. Patients and Methods Patients were randomly assigned (1:1:1) to receive docetaxel 75 mg/m 2 intravenously (IV) on day 1 of a 3-week cycle (arm A), docetaxel 75 mg/m 2 IV plus ramucirumab 10 mg/kg IV on day 1 of a 3-week cycle (arm B), or docetaxel 75 mg/m 2 IV on day 1 plus icrucumab 12 mg/kg IV on days 1 and 8 of a 3-week cycle (arm C). Treatment continued until disease progression or unacceptable toxicity. The primary end point was investigator-assessed progression-free survival (PFS). Results A total of 140 patients were randomly assigned and treated in arms A (n = 45), B (n = 46), or C (n = 49). PFS was significantly longer in arm B compared with arm A (median, 5.4 months; 95% CI, 3.1 to 6.9 months v 2.8 months; 95% CI, 1.9 to 3.6 months; stratified hazard ratio, 0.389; 95% CI, 0.235 to 0.643; P = .0002). Arm C did not experience improved PFS compared with arm A (1.6 months; 95% CI, 1.4 to 2.9; stratified hazard ratio, 0.863; 95% CI, 0.550 to 1.357; P = .5053). The most common grade 3 or worse adverse events (arms A, B, and C) were neutropenia (36%, 33%, and 39%), fatigue (13%, 30%, and 20%), febrile neutropenia (13%, 17%, and 6.1%), and anemia (6.7%, 13%, and 14%, respectively). Conclusion The addition of ramucirumab to docetaxel met the prespecified efficacy end point for prolonging PFS in patients with locally advanced or metastatic urothelial carcinoma receiving second-line treatment and warrants further investigation in the phase III setting.
Family doctors and contraception. (Letter to the editor)
Authors: Furman Bl, Harvey Al, Wadsworth Rm
Journal: BMJ (1972)

The vice president of the Pharmaceutical Society Mr. J.P. Kerr speaking in Glasgow on Sunday March 26 at a conference sponsored by the Socialist Medical Association pressed the Societys view that oral contraceptives should be available  on the National Health Service.  Mr.  Kerr outlined the Societys proposed scheme in which family doctors would issue prescriptions on a modified E.C.10 form.  This special form would be similar to the E.C.19 form and would contain a total of 3 separate prescriptions.  At each consultation the doctor would issue prescriptions for 3 or 6 months supply (see the Pharmaceutical Journal April 8 1972 p. 312).  Dr. Lorna Naismith speaking on behalf of the Family Planning Association agreed that contraceptive services should be completely free.  However she felt that contraceptives should be supplied only by those who had received special training.  Asked to comment on the Pharmaceutical Societys plan Dr. Maurice Miller (who takes a weekly birth control session at a London Family Planning Association clinic) replied that he also had reservations that the training of many general  practitioners in this specialized field was not deep enough.  Early detection of untoward side effects for which the family doctor had neither the time nor the experience was best carried out at family planning clinics he added.(FULL TEXT)
Effects of Varenicline on Smoking Cessation in Adults With Stably Treated Current or Past Major Depression
Authors: Robert M. Anthenelli, Chad Morris, Tanya S. Ramey, Sarah J. Dubrava, Kostas Tsilkos, Cristina Russ, Carla Yunis
Journal: Annals of Internal Medicine (2013)

Varenicline increases quit rates in smokers, but its efficacy and safety in patients with psychiatric disorders are unclear. This trial randomly assigned smokers with stable treated current or past...
Biological Parameters Predictive Of Percent Dense Red Blood Cell Decrease Under Hydroxyurea Therapy
Authors: Marie Georgine Rakotoson, Gaetana Di Liberto, Anoosha Habibi, Christine Fauroux, Sanam Khorgami, Dora Bachir, France Noizat-Pirenne, Frederic Galacteros, Pablo Bartolucci
Journal: Blood (2013)
Mammary Tumor-Agent in the Sperm of High-Cancer-Strain Male Mice
Authors: O. Muhlbock, M. D., Ph. D.
Journal: JNCI Journal of the National Cancer Institute (1950)

Mammary Tumor-Agent in the Sperm of High-Cancer-Strain Male Mice Get access O. Muhlbock, M. D., Ph. D. O. Muhlbock, M. D., Ph. D. Biological Department of the Laboratory of the Antoni van Leeuwenhoek-huis, The Netherlands' Cancer Institute, Amsterdam Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 4, February 1950, Pages 861–864, https://doi.org/10.1093/jnci/10.4.861 Published: 01 February 1950 Article history Received: 04 October 1949 Published: 01 February 1950
Abstract P218: Identification of One Retinoic Acid Responsive Element in Glucokinase Gene Promoter
Authors: Guoxun Chen, Rui Li, Wei Chen, Yang Li, Yan Zhang
Journal: Circulation (2012)

Introduction: Studies have shown that vitamin A (VA) status affected hepatic glycogen content and body lipid levels in rats. The active metabolite of VA, retinoic acid (RA), regulates gene expression via activation of both retinoic acid receptor (RAR) and retinoid X receptor (RXR) bound to retinoic acid responsive element (RARE). We have reported that retinoids synergized with insulin to induce glucokinase gene ( Gck ) in primary rat hepatocyes. Hypothesis: We hypothesize that the rat promoter of Gck contains RARE(s). Methods: To identify the RARE(s) in the Gck promoter, we have made (1) a series of luciferase reporter gene constructs containing shortened DNA fragments of Gck promoter; (2) expression vectors containing cDNAs of rat RARα, RXRα and RXRγ; (3) linker-scan mutant reporter constructs covering 0.2 kb of the proximal Gck promoter region and a 20 bp region which disrupt the RA response. The responses of these reporter constructs to RA and the effects of the co-transfection of RAR and RXR on their activation were analyzed in primary hepatocytes and INS-1 insulinoma cells using dual luciferase assay. Results: (1) RA and RA + insulin, not insulin, activated the reporter gene constructs containing 1, 0.8, 0.6, 0.4, and 0.2 kb of Gck promoter in primary hepatocytes (from 1.7- to 2.6-fold). (2) RA alone did not activate Gck promoter constructs in INS-1 cells. However, co-transfection of RAR with reporter gene constructs restored and improved RA response of them in INS-1 cells and primary hepatocytes, respectively. (3) Two consecutive linker-scan mutant reporter constructs covering about 20 bp of the proximal region of Gck promoter, but not the adjacent ones, completely lost the response to RA. (4) One of the five linker-scan mutant reporter constructs covering this 20 bp region completed disrupted the RA response, demonstrating the identification of a RARE. Conclusions: RA induces the activation of Gck promoter constructs in primary hepatocytes. INS-1 cells are a useful tool for analyzing liver Gck promoter activation by RA with co-transfection of RAR/RXR. For the first time, one RARE is identified in the proximal region of rat Gck promoter. Further studies are needed to determine the roles of this identified RARE in mediating Gck expression in responses to hormonal and nutritional stimuli. Funding(This research has received full or partial funding support from the American Heart Association, National Center)
Early stopping, interim analyses, and monitoring committees: what are the tradeoffs?
Authors: M Zelen
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.9.1314 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3625252 Early stopping, interim analyses, and monitoring committees: what are the tradeoffs? M ZelenxM ZelenSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.9.1314 PDF "Early stopping, interim analyses, and monitoring committees: what are the tradeoffs?." Journal of Clinical Oncology, 5(9), pp. 1314–1315© 1987 by American Society of Clinical Oncology
Visual Acuity Screening Among Asymptomatic Older Adults
Authors: Paul Lee
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply: “Obstructive Sleep Apnea, Sleep Duration, and Fasting Glucose” and “The Impact of Obesity on the Association between Obstructive Sleep Apnea and Glucose Metabolism”
Authors: Jessie P. Bakker, Jia Weng, Rui Wang, Susan Redline, Naresh M. Punjabi, Sanjay R. Patel
Journal: American Journal of Respiratory and Critical Care Medicine (2016)
Race, Socioeconomic Status, and Other Prognostic Factors for Survival From Prostate Cancer&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: H H Dayal, L Polissar, S Dahlberg
Journal: JNCI Journal of the National Cancer Institute (1985)

Survival data on prostate cancer patients from 11 Comprehensive Cancer Centers contributing data to the Centralized Cancer Patient Data System were analyzed to examine the contribution of various factors to the probability of survival from prostate carcinoma. Application of a number of exclusion criteria resulted in a series of 2,513 patients (1,032 blacks and 1,481 Caucasians) for whom complete data on variables of interest were available. The stage of disease at diagnosis was a major determinant of survival. The proportion of blacks presenting the disease in advanced stage was substantially higher than that of Caucasians--a difference which was maintained within each socio-economic status (SES) category. Caucasian patients had a better prognosis than blacks for each disease stage. A dose-response relationship between SES and survival prognosis was observed and this relationship persisted for each stage of the disease. Although both race and SES turned out to be significant in regression models in which one or the other was considered, the model including both race and SES showed only SES to be a significant factor. Hence it can be hypothesized that the racial difference in the survival prognosis for prostate cancer is, to a large extent due to the differences in the distribution of SES in the two races.
Microsatellite instability in gastric MALT lymphomas and other associated neoplasms
Authors: D. Furlan, F. Bertoni, R. Cerutti, M. Taborelli, G. Pinotti, E. Roggero, F. Cavalli, M. Bonato, E. Zucca, C. Capella
Journal: Annals of Oncology (1999)